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Sample records for acid-fast intranuclear inclusion

  1. Acid-fast intranuclear inclusion bodies in the kidneys of mallards fed lead shot

    USGS Publications Warehouse

    Locke, L.N.; Bagley, G.E.; Irby, H.D.

    1966-01-01

    Acid-fast intranuclear inclusion bodies were found in the cells of the proximal convoluted tubules of the kidneys of mallards fed one, two, three or eight number 6 lead shot and maintained on cracked or whole corn and on grain-duck pellet diets. No acid-fast inclusion bodies were found in mallards fed one or three lead shot but maintained on a duck pellet ration. Dietary factors may be responsible for the failure of mallards fed a duck pellet ration to develop lead Inclusion bodies when treated with one or three lead shot. The authors suggest these inclusion bodies can be used as presumptive evidence for lead intoxication in mallards.

  2. Ultrastructural cytochemical analysis of intranuclear arsenic inclusions

    SciTech Connect

    Sorensen, E.M.B.

    1987-01-01

    To establish the chemical composition of the arsenic inclusion, freshly isolated preparations of inclusions and epon-embedded thin sections of inclusions were subjected to ultrastructural cytochemical analysis. Intranuclear inclusions are composed of amorphous, arsenic-containing subunits aligned linearly to form a coiled complex. Lipase, ribonuclease, deoxyribonuclease, trypsin, pepsin, protease, amylase, or ethylenediaminetetraacetic acid (EDTA) was used to digest or chelate these inclusions. Following enzymatic digestion or chelation, the electron opacity of inclusions was compared with that of control sections exposed for equal times to equivalent solutions lacking the enzymes. Exposure to amylase caused a consistent reduction in the electron opacity of thin sections of inclusions and almost complete digestion of the freshly isolated preparations of inclusions. This was indicative of the presence of a carbohydrate moiety within arsenic inclusions. Incubation of inclusions with EDTA resulted in solubilization of freshly isolated and thin-sectioned embedded material. These data indicated that the intranuclear arsenic inclusion is composed of both metallic and carbohydrate moieties, confirming earlier studies which identified arsenic within inclusions using instrumental neutron activation analysis and x-ray microprobe analysis.

  3. Neuronal intranuclear inclusion disease and juvenile parkinsonism.

    PubMed

    O'Sullivan, J D; Hanagasi, H A; Daniel, S E; Tidswell, P; Davies, S W; Lees, A J

    2000-09-01

    Juvenile parkinsonism (onset age <20 yrs) is uncommon and few cases with neuropathologic confirmation have been reported. We present the case of a 17-year-old boy who presented with asymmetric arm tremor and bulbar symptoms. His paternal great aunt had parkinsonism with onset at age 22 years. Examination revealed parkinsonism in the absence of additional neurologic signs except for delayed pupillary responses to light. He responded well to levodopa but developed motor fluctuations and disabling dyskinesias after 3 years of treatment. Following attempted withdrawal of levodopa at age 24 years, he developed severe aspiration pneumonia complicated by cardiorepiratory arrests and he died 6 months later. At autopsy, the dominant histologic feature was wide-spread neuronal hyaline intranuclear inclusions. Neuronal depletion was observed in the substantia nigra, locus ceruleus, and, to a lesser extent, in the frontal cortex, and inclusions were particularly prominent in these areas. Inclusions were immunoreactive for ubiquitin and were typical of those seen in neuronal intranuclear inclusion disease (NIID), a rare, multisytem neurodegenerative disease. NIID should be considered in the differential diagnosis of juvenile parkinsonism. A link between NIID and hereditary neurodegenerative disorders characterized by expanded polyglutamine tracts is supported by the similar appearance of intranuclear inclusions in both conditions and by a family history in some cases of NIID. PMID:11009211

  4. Neuronal intranuclear inclusion disease in identical twins.

    PubMed

    Haltia, M; Somer, H; Palo, J; Johnson, W G

    1984-04-01

    A pair of female identical twins exhibited slurred speech, nystagmus, and oculogyral spasms starting at age 11. The patients then had episodic rage, extrapyramidal and lower motor neuron abnormalities, and grand mal seizures, but retained largely normal intelligence, until death at age 21. Severe loss of nigral and craniospinal motor neurons was noted postmortem. Round, eosinophilic, autofluorescent inclusion bodies, 3 to 10 microns in diameter, were observed in the nuclei of most nerve cell types of the central and peripheral nervous systems and retina. Ultrastructurally the inclusions appeared as masses of filaments without a limiting membrane, the constituent filaments having a diameter of 8.5 to 9.5 nm. Histochemical results suggested the presence of proteins with a high content of tryptophan. Four similar cases have been reported previously under various designations. We propose the name neuronal intranuclear inclusion disease for the disorder. PMID:6331275

  5. An unusual degenerative disorder of neurons associated with a novel intranuclear hyaline inclusion (neuronal intranuclear hyaline inclusion disease). A clinicopathological study of a case.

    PubMed

    Sung, J H; Ramirez-Lassepas, M; Mastri, A R; Larkin, S M

    1980-03-01

    A 21-year-old woman with an unusual, progressive, degenerative neurological disorder is described. The disorder is characterized clinically by behavioral abnormality, peculiar involuntary movements, and ataxia starting in early childhood and subsequent development of dementia, choreoathetosis, rectal and bladder incontinence, bulbar and spinal muscular weakness, pes cavus, kyphoscoliosis, and generalized seizures. The clinical manifestations are correlated, with widespread pathological changes affecting almost all neuronal systems. The pathological changes are discussed in relation to the wide spectrum of "multisystem atrophies." Particular attention is directed to the ubiquitous occurrence of a novel intranuclear, eosinophilic, hyaline inclusion in almost all types of central, peripheral, and autonomic neurons. The ubiquitous neuronal involvement seems to explain the diffuse multiple system degeneration. The pathogenesis of the neuronal inclusions is unknown, but it is speculated that the disorder may represent a metabolic abnormality affecting the nuclear protein of neurons, rather than a viral infection. The pathological features, consisting of the neuronal intranuclear hyaline inclusions associated with multiple system atrophy, have not hitherto been described, and "neuronal intranuclear hyaline inclusion disease" is proposed as a name for the disorder. Rectal biopsy demonstrating the intranuclear hyaline inclusions in ganglion cells of the hyenteric plexuses may serve as a diagnostic procedure for the disorder. PMID:6154779

  6. Distribution and frequency of intranuclear inclusions in female CGG KI mice modeling the fragile X premutation☆

    PubMed Central

    Schluter, Erik W.; Hunsaker, Michael R.; Greco, Claudia M.; Willemsen, Rob; Berman, Robert F.

    2012-01-01

    The fragile X-associated tremor/ataxia syndrome (FXTAS) is an adult-onset neurodegenerative disorder caused by CGG trinucleotide repeat expansions in the fragile X mental retardation 1 (FMR1) gene. The neuropathological hallmark of FXTAS is the presence of ubiquitin-positive intranuclear inclusions in neurons and in astroglia. Intranuclear inclusions have also been reported in the neurons of male CGG KI mice carrying an expanded CGG trinucleotide repeat and used to model FXTAS, but no study has been carried out quantifying inclusions in female CGG KI mice heterozygous for the fragile X premutation. We used histologic and immunocytochemical methods to determine the pathological features of intranuclear inclusions in astroglia and neurons. In female CGG KI mice, ubiquitin-positive intranuclear inclusions were found in neurons and astroglia throughout the brain in cortical and subcortical regions. These inclusions increased in number and became larger with advanced age and increasing CGG repeat length, supporting hypotheses that these pathologic features are progressive across the lifespan. The number of inclusions in neurons was reduced by ~25% in female CGG KI mice compared to male CGG KI mice, but not so low as the 50% predicted. These data emphasize the need to evaluate the neurocognitive and pathological features in female carriers of the fragile X premutation with and without FXTAS symptomatology is warranted, as this population shows similar neuropathological features present in male FXTAS patients. PMID:22796595

  7. Neuronal intranuclear inclusions are ultrastructurally and immunologically distinct from cytoplasmic inclusions of neuronal intermediate filament inclusion disease.

    PubMed

    Mosaheb, Sabrina; Thorpe, Julian R; Hashemzadeh-Bonehi, Lida; Bigio, Eileen H; Gearing, Marla; Cairns, Nigel J

    2005-10-01

    Abnormal neuronal cytoplasmic inclusions (NCIs) containing aggregates of alpha-internexin and the neurofilament (NF) subunits, NF-H, NF-M, and NF-L, are the signature lesions of neuronal intermediate filament (IF) inclusion disease (NIFID). The disease has a clinically heterogeneous phenotype, including frontotemporal dementia, pyramidal and extrapyramidal signs presenting at a young age. NCIs are variably ubiquitinated and about half of cases also have neuronal intranuclear inclusions (NIIs), which are also ubiquitinated. NIIs have been described in polyglutamine-repeat expansion diseases, where they are strongly ubiquitin immunoreactive. The fine structure of NIIs of NIFID has not previously been described. Therefore, to determine the ultrastructure of NIIs, immunoelectron microscopy was undertaken on NIFID cases and normal aged control brains. Our results indicate that the NIIs of NIFID are strongly ubiquitin immunoreactive. However, unlike NCIs which contain ubiquitin, alpha-internexin and NF epitopes, NIIs contain neither epitopes of alpha-internexin nor NF subunits. Neither NIIs nor NCIs were recognised by antibodies to expanded polyglutamine repeats. The NII of NIFID lacks a limiting membrane and contains straight filaments of 20 nm mean width (range 11-35 nm), while NCIs contain filaments with a mean width of 10 nm (range 5-18 nm; t-test, P<0.001). Biochemistry revealed no differences in neuronal IF protein mobilities between NIFID and normal brain tissue. Therefore, NIIs of NIFID contain filaments morphologically and immunologically distinct from those of NCIs, and both types of inclusion lack expanded polyglutamine tracts of the triplet-repeat expansion diseases. These observations indicate that abnormal protein aggregation follows separate pathways in different neuronal compartments of NIFID. PMID:16025283

  8. Intranuclear Pseudo-inclusions and Grooves in Fine Needle Aspiration Cytology of Pulmonary Carcinoid Tumor.

    PubMed

    Mokhtari, Maral; Kumar, Perikala Vijayananda

    2016-02-01

    Cytologic findings of pulmonary carcinoid have been well described. We report new cytological findings in a case of carcinoid tumor. The patient is a 36-year-old man presenting with hemoptysis of about six months in duration. Chest CT scans showed a well-defined round polypoid lesion measuring 1 × 1 cm within the right upper lobe of the bronchus with hyperinflation of the right upper lobe. Trans-bronchial fine needle aspiration and biopsy were done. Cytologic smears showed isolated and loose clusters of uniform round to spindle shape cells with round centrally located nuclei, fine granular (salt and pepper) chromatin and pale cytoplasm. Intranuclear pseudo-inclusions and grooves were seen in some tumor cells. No mitotic figures or necrosis were evident. A cytological diagnosis of carcinoid tumor was made and histopathologic examination and subsequent immunohistochemical study confirmed the diagnosis. Carcinoid tumor may be reliably diagnosed on fine needle aspiration cytology smears. Intranuclear pseudo-inclusions and grooves may be evident in tumor cells. PMID:26838088

  9. Valosin-containing protein immunoreactivity in tauopathies, synucleinopathies, polyglutamine diseases and intranuclear inclusion body disease.

    PubMed

    Mori, Fumiaki; Tanji, Kunikazu; Toyoshima, Yasuko; Sasaki, Hidenao; Yoshida, Mari; Kakita, Akiyoshi; Takahashi, Hitoshi; Wakabayashi, Koichi

    2013-12-01

    Valosin-containing protein (VCP) is associated with multiple cellular functions, including ubiquitin-dependent protein degradation. Mutations in VCP are known to cause inclusion body myopathy with Paget's disease and frontotemporal dementia and familial amyotrophic lateral sclerosis (fALS; ALS14), both of which are characterized by trans-activation response DNA protein 43 (TDP-43)-positive neuronal cytoplasmic and nuclear inclusions. Recently, immunoreactivity for fALS-associated proteins (TDP-43, fused in sarcoma (FUS), optineurin and ubiquilin-2) were reported to be present in cytoplasmic and nuclear inclusions in various neurodegenerative diseases. However, the extent and frequency of VCP-immunoreactive structures in these neurodegenerative diseases are uncertain. We immunohistochemically examined the brains of 72 cases with neurodegenerative diseases and five control cases. VCP immunoreactivity was present in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and neuronal nuclear inclusions in five polyglutamine diseases and intranuclear inclusion body disease, as well as in Marinesco bodies in aged control subjects. However, other neuronal and glial cytoplasmic inclusions in tauopathies and TDP-43 proteinopathies were unstained. These findings suggest that VCP may have common mechanisms in the formation or degradation of cytoplasmic and nuclear inclusions of neurons, but not of glial cells, in several neurodegenerative conditions. PMID:23782134

  10. Memory Loss and Frontal Cognitive Dysfunction in a Patient with Adult-onset Neuronal Intranuclear Inclusion Disease.

    PubMed

    Araki, Kunihiko; Sone, Jun; Fujioka, Yusuke; Masuda, Michihito; Ohdake, Reiko; Tanaka, Yasuhiro; Nakamura, Tomohiko; Watanabe, Hirohisa; Sobue, Gen

    2016-01-01

    Neuronal intranuclear inclusion disease (NIID) is an uncommon progressive neurodegenerative disorder. Adult-onset NIID can result in prominent dementia. We herein describe the case of a 74-year-old man who presented with dementia, cerebellar ataxia, neuropathy, and autonomic dysfunction. Diffusion-weighted imaging showed hyperintensity of the corticomedullary junction. Fluid-attenuated inversion recovery images showed frontal-dominant white matter hyperintensity. NIID was diagnosed from the presence of intranuclear inclusions in a skin biopsy sample. Neuropsychological testing revealed memory loss and frontal cognitive dysfunction, especially in relation to language and executive functions. We were therefore able to confirm the association of NIID with cognitive dysfunction. PMID:27523009

  11. Studies of a nuclear matrix protein restricted to normal brain cells and lead-induced intranuclear inclusion bodies of kidney

    SciTech Connect

    Shelton, K.; Egle, P.; Redford, K.; Bigbee, J.

    1986-05-01

    A nuclear matrix protein, p32/6.3, with an unusual tissue distribution, has been identified. Protein from 21 tissues was surveyed by immunoprobing Western blots. In normal adult rats p32/6.3 is found only in grey matter from the cerebrum and the cerebellum, occurring in both neurons and astrocytes. Other brain cell types have not been examined. The protein appears to be developmentally regulated. It is detectable in the brain within a few days after birth and reaches adult levels within one to two weeks. Brain p32/6.3 has been found in all animals tested including rat, mouse, dog, cow, pig, chicken and human. This conservation indicates a fundamental role for p32/6.3 in the nucleus of brain cells. Possible functions for p32/6.3 may be indicated by a second novel occurrence. Chronic lead poisoning characteristically induces intranuclear inclusion bodies in the cells lining kidney proximal tubules. p32/6.3 is a major constituent of these inclusion bodies. They are also rich in lead and other metals including calcium, iron, zinc, copper and cadmium. These diverse observations suggest that p32/6.3 may have a role in metal homeostasis in the brain of normal animals.

  12. Neuronal ubiquitinated intranuclear inclusions in familial and non-familial frontotemporal dementia of the motor neuron disease type associated with amyotrophic lateral sclerosis.

    PubMed

    Bigio, Eileen H; Johnson, Nancy A; Rademaker, Alfred W; Fung, Bing B; Mesulam, M-Marsel; Siddique, Nailah; Dellefave, Lisa; Caliendo, Janice; Freeman, Stefanie; Siddique, Teepu

    2004-08-01

    Ubiquitinated cytoplasmic inclusions (Ub-CIs) in superficial frontal cortex and dentate gyrus neurons are the hallmark of frontotemporal degeneration of the motor neuron disease-type (FTD-MND-type). To date, 2 reports have described intranuclear ubiquitinated inclusions (Ub-INIs) in 9 cases of familial FTD-MND-type (without clinical or pathologic motor neuron disease, MND). In the current study we found an additional 11 cases with Ub-INIs. We have identified for the first time among these cases 2 with a negative family history and 3 that have concomitant amyotrophic lateral sclerosis (ALS). The results of the present study i) confirm a previous report of significantly lower average brain weight and longer duration in cases with Ub-INIs, ii) reveal significantly greater striatal neuronal loss and gliosis in cases with intranuclear inclusions, and iii) demonstrate that intranuclear inclusions correlate with cytoplasmic inclusions and dystrophic neurites in frontal cortex and striatum but not in dentate gyrus. In addition, the current study confirms that Ub-INIs are found in familial FTD-MND-type, but also extends the presence of Ub-INIs to familial FTD-MND (with concomitant ALS), and probably also to non-familial FTD-MND-type. PMID:15330335

  13. Inclusion of correlations in the empherical selection of intranuclear cascade nucleons from high energy hadron-nucleus collisions

    NASA Astrophysics Data System (ADS)

    Alsmiller, F. S.; Alsmiller, R. G.

    1989-06-01

    The very high energy (5 GeV to 20 Tev) hadron-nucleus differential particle production model found in the Monte Carlo transport code FLUKA87 has been adapted for inclusion in the transport code HETC88. The empirical selection of intranuclear cascade nucleons has been modified to provide simple correlations with the randomly selected number of hadron-nucleon collisions. A standard method of calculating the extension energy of the compound nucleus preceding an added evaporation step by assuming the particles are produced in a one-dimensional nuclear well is applied. This method, coupled with the above correlations, lead to improved correlations of the excitation energy with the A and Z of the compound nucleus, and then to greatly improved distributions of the residual nuclei following evaporation. The frequency distribution of low enegy ( β < 0.7) charged particles show good agreement with experiment for 200 GeV protons incident on emulsions. Average multiplicities of showe and grey particles after evaporation for protons and pions incident on several elements are also compared with experiment.

  14. Atypical sporadic CJD-MM phenotype with white matter kuru plaques associated with intranuclear inclusion body and argyrophilic grain disease.

    PubMed

    Berghoff, Anna S; Trummert, Anita; Unterberger, Ursula; Ströbel, Thomas; Hortobágyi, Tibor; Kovacs, Gabor G

    2015-08-01

    We describe an atypical neuropathological phenotype of sporadic Creutzfeldt-Jakob disease in a 76-year-old man. The clinical symptoms were characterized by progressive dementia, gait ataxia, rigidity and urinary incontinence. The disease duration was 6 weeks. MRI did not show prominent atrophy or hyperintensities in cortical areas, striatum or thalamus. Biomarker examination of the cerebrospinal fluid deviated from that seen in pure Alzheimer's disease. Triphasic waves in the EEG were detected only later in the disease course, while 14-3-3 assay was positive. PRNP genotyping revealed methionine homozygosity (MM) at codon 129. Neuropathology showed classical CJD changes corresponding to the MM type 1 cases. However, a striking feature was the presence of abundant kuru-type plaques in the white matter. This rare morphology was associated with neuropathological signs of intranuclear inclusion body disease and advanced stage of argyrophilic grain disease. These alterations did not show correlation with each other, thus seemed to develop independently. This case further highlights the complexity of neuropathological alterations in the ageing brain. PMID:25783686

  15. A quantitative investigation of neuronal cytoplasmic and intranuclear inclusions in the pontine and inferior olivary nuclei in multiple system atrophy.

    PubMed

    Nishie, M; Mori, F; Yoshimoto, M; Takahashi, H; Wakabayashi, K

    2004-10-01

    Multiple system atrophy (MSA) is a sporadic neurodegenerative disease characterized by the presence of neuronal and oligodendroglial alpha-synuclein aggregates. To investigate the relationship between the occurrence of neuronal cytoplasmic and intranuclear inclusions (NCIs and NNIs, respectively) and the progression of neuronal degeneration, we performed a quantitative analysis of the pontine and inferior olivary nuclei based on 14 cases of MSA. alpha-Synuclein immunohistochemistry revealed that NCIs and NNIs were present in both brain nuclei in all the cases. The average incidence of NCIs in the pontine and inferior olivary nuclei was 9.1% and 25.8%, respectively, and that of NNIs was 9.2% and 9.0%, respectively. The number of NNIs was strongly correlated with that of neurones in the pontine and inferior olivary nuclei. Although the number of NCIs was not correlated with the neuronal population in both nuclei, the NCI count in patients with moderate MSA was higher than in patients with mild MSA. The NNI count was much higher than the NCI count in the pontine nucleus in four patients, and was the same in the olivary nucleus in three of the four patients. Moreover, the neuronal population in the NNI-predominant cases was significantly higher than in the NCI-predominant cases. These findings suggest that NCI formation is accelerated by the progression of the disease process, and that in MSA, NNI formation is an earlier phenomenon than NCI formation. PMID:15488031

  16. Acid-fast stain

    MedlinePlus

    ... this page: //medlineplus.gov/ency/article/003766.htm Acid-fast stain To use the sharing features on this page, please enable JavaScript. The acid-fast stain is a laboratory test that determines ...

  17. Acid-fast stain

    MedlinePlus

    The acid-fast stain is a laboratory test that determines if a sample of tissue, blood, or other body ... dye. The slide is then washed with an acid solution and a different stain is applied. Bacteria ...

  18. Intranuclear Actin Regulates Osteogenesis

    PubMed Central

    Sen, Buer; Xie, Zhihui; Uzer, Gunes; Thompson, William R.; Styner, Maya; Wu, Xin; Rubin, Janet

    2016-01-01

    Depolymerization of the actin cytoskeleton induces nuclear trafficking of regulatory proteins and global effects on gene transcription. We here show that in mesenchymal stem cells (MSCs), cytochalasin D treatment causes rapid cofilin-/importin-9-dependent transfer of G-actin into the nucleus. The continued presence of intranuclear actin, which forms rod-like structures that stain with phalloidin, is associated with induction of robust expression of the osteogenic genes osterix and osteocalcin in a Runx2-dependent manner, and leads to acquisition of osteogenic phenotype. Adipogenic differentiation also occurs, but to a lesser degree. Intranuclear actin leads to nuclear export of Yes-associated protein (YAP); maintenance of nuclear YAP inhibits Runx2 initiation of osteogenesis. Injection of cytochalasin into the tibial marrow space of live mice results in abundant bone formation within the space of 1 week. In sum, increased intranuclear actin forces MSC into osteogenic lineage through controlling Runx2 activity; this process may be useful for clinical objectives of forming bone. PMID:26140478

  19. p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS.

    PubMed

    Al-Sarraj, Safa; King, Andrew; Troakes, Claire; Smith, Bradley; Maekawa, Satomi; Bodi, Istvan; Rogelj, Boris; Al-Chalabi, Ammar; Hortobágyi, Tibor; Shaw, Christopher E

    2011-12-01

    Neuronal cytoplasmic inclusions (NCIs) containing phosphorylated TDP-43 (p-TDP-43) are the pathological hallmarks of motor neuron disease/amyotrophic lateral sclerosis (MND/ALS) and FTLD-TDP. The vast majority of NCIs in the brain and spinal cord also label for ubiquitin and p62, however, we have previously reported a subset of TDP-43 proteinopathy patients who have unusual and abundant p62 positive, TDP-43 negative inclusions in the cerebellum and hippocampus. Here we sought to determine whether these cases carry the hexanucleotide repeat expansion in C9orf72. Repeat primer PCR was performed in 36 MND/ALS, FTLD-MND/ALS and FTLD-TDP cases and four controls. Fourteen individuals with the repeat expansion were detected. In all the 14 expansion mutation cases there were abundant globular and star-shaped p62 positive NCIs in the pyramidal cell layer of the hippocampus, the vast majority of which were p-TDP-43 negative. p62 positive NCIs were also abundant in the cerebellar granular and molecular layers in all cases and in Purkinje cells in 12/14 cases but they were only positive for p-TDP-43 in the granular layer of one case. Abundant p62 positive, p-TDP-43 negative neuronal intranuclear inclusions (NIIs) were seen in 12/14 cases in the pyramidal cell layer of the hippocampus and in 6/14 cases in the cerebellar granular layer. This unusual combination of inclusions appears pathognomonic for C9orf72 repeat expansion positive MND/ALS and FTLD-TDP which we believe form a pathologically distinct subset of TDP-43 proteinopathies. Our results suggest that proteins other than TDP-43 are binding p62 and aggregating in response to the mutation which may play a mechanistic role in neurodegeneration. PMID:22101323

  20. Intranuclear bundles of microfilaments and microtubules in chromaffin cells of the auricle of the heart of a lungfish, Protopterus aethiopicus.

    PubMed

    Scheuermann, D W; Adriaensen, D; De Groodt-Lasseel, M H

    1988-01-01

    Intranuclear microtubular-microfilamentous rod-like inclusions were investigated in chromaffin cells of the auricle of the heart of lungfishes. In conventional electron microscopy, these inclusions reveal a wide variety in appearance, depending on their orientation to the plane of sectioning. Whereas originally they were merely interpreted as a bundle of microfilaments, application of a goniometer stage showed the rod- or spindle-shaped intranuclear inclusions to have a basic substructure of parallel arranged microtubules among microfilaments, which are clearly connected to chromatin granules, occasionally penetrating dense areas of chromatin. The chemical nature and biological significance of these structures, which so far remain enigmatic, are discussed. PMID:3227775

  1. Inclusion.

    ERIC Educational Resources Information Center

    Nathanson, Jeanne H., Ed.

    1992-01-01

    This theme journal issue focuses on current activities of the Office of Special Education and Rehabilitative Services which stress inclusion of students with disabilities in the mainstream. It begins with a message from the Assistant Secretary, Robert R. Davila which examines the full meaning of an "inclusive" education. Next, Barbara Buswell and…

  2. AFB (Acid-Fast Bacillus) Smear and Culture

    MedlinePlus

    ... Mycobacteria Smear; Mycobacteria Culture; TB NAAT Formal name: Acid-Fast Bacillus Smear and Culture and Sensitivity; Mycobacteria tuberculosis Nucleic Acid Amplification Test Related tests: TB Screening Tests ; Bacterial ...

  3. Cytomegalic inclusion disease in the east African headgehog.

    PubMed

    Karstad, L

    1975-04-01

    Cytomegaly with intranuclear inclusion bodies was found in the duct epithelium of the salivary glands of five of ten hedgehogs (Atelerix albiventris). Cytomegalovirus infection was presumed to be the cause. PMID:167206

  4. Intranuclear bacteria: inside the cellular control center of eukaryotes.

    PubMed

    Schulz, Frederik; Horn, Matthias

    2015-06-01

    Intracellular bacteria including major pathogens live in the cytoplasm or in cytoplasmic vacuoles within their host cell. However, some can invade more unusual intracellular niches such as the eukaryotic nucleus. Phylogenetically diverse intranuclear bacteria have been discovered in various protist, arthropod, marine invertebrate, and mammalian hosts. Although targeting the same cellular compartment, they have apparently developed fundamentally-different infection strategies. The nucleus provides a rich pool of nutrients and protection against host cytoplasmic defense mechanisms; intranuclear bacteria can directly manipulate the host by interfering with nuclear processes. The impact on their host cells ranges from stable associations with a neutral or beneficial effect on host fitness to rapid host lysis. The analysis of the intranuclear lifestyle will extend our current framework for understanding host-pathogen interactions. PMID:25680230

  5. Inclusion body hepatitis in kestrels (Falco sparverius)

    USGS Publications Warehouse

    Sileo, L.; Franson, J.C.; Graham, D.L.; Domermuth, C.H.; Rattner, B.A.; Pattee, O.H.

    1982-01-01

    Inclusion body disease of suspected adenovirus etiology was the apparent cause of death of 9 captive kestrels (Falco sparverius). Cloacal hemorrhage was the only prominent gross lesion; disseminated hepatocellular necrosis and intranuclear inclusion bodies were evident microscopically. Attempts to reproduce the disease, and to propagate and serologically characterize the agent were unsuccessful.

  6. Nucleon removal from unstable nuclei investigated via intranuclear cascade

    SciTech Connect

    Louchart, C.; Obertelli, A.; Boudard, A.; Flavigny, F.

    2011-01-15

    An intranuclear cascade model for one-nucleon removal cross sections at intermediate energies beyond the sudden and inert-core assumptions is presented. Indirect processes are taken into account in the reaction mechanism via a Monte Carlo-based approach. The formalism is applied to a set of weakly bound nuclei for which data are available. Results are in correct agreement with experiment including the case of deeply bound nucleon removal. A comparison to eikonal predictions is performed.

  7. Intranuclear dynamics of the Nup107-160 complex

    PubMed Central

    Morchoisne-Bolhy, Stéphanie; Geoffroy, Marie-Claude; Bouhlel, Imène B.; Alves, Annabelle; Audugé, Nicolas; Baudin, Xavier; Van Bortle, Kevin; Powers, Maureen A.; Doye, Valérie

    2015-01-01

    Nup98 is a glycine-leucine-phenylalanine-glycine (GLFG) repeat–containing nucleoporin that, in addition to nuclear transport, contributes to multiple aspects of gene regulation. Previous studies revealed its dynamic localization within intranuclear structures known as GLFG bodies. Here we show that the mammalian Nup107-160 complex (Y-complex), a major scaffold module of the nuclear pore, together with its partner Elys, colocalizes with Nup98 in GLFG bodies. The frequency and size of GLFG bodies vary among HeLa sublines, and we find that an increased level of Nup98 is associated with the presence of bodies. Recruitment of the Y-complex and Elys into GLFG bodies requires the C-terminal domain of Nup98. During cell division, Y-Nup–containing GLFG bodies are disassembled in mitotic prophase, significantly ahead of nuclear pore disassembly. FRAP studies revealed that, unlike at nuclear pores, the Y-complex shuttles into and out of GLFG bodies. Finally, we show that within the nucleoplasm, a fraction of Nup107, a key component of the Y-complex, displays reduced mobility, suggesting interaction with other nuclear components. Together our data uncover a previously neglected intranuclear pool of the Y-complex that may underscore a yet-uncharacterized function of these nucleoporins inside the nucleus, even in cells that contain no detectable GLFG bodies. PMID:25904327

  8. Reduction of Acid-Fast and Non-Acid-Fast Bacteria by Point of Use Coagulation-Flocculation-Disinfection

    PubMed Central

    Casanova, Lisa M.; Sobsey, Mark D.

    2015-01-01

    Point of use (POU) household water treatment is increasingly being adopted as a solution for access to safe water. Non-tuberculous Mycobacteria (NTM) are found in water, but there is little research on whether NTM survive POU treatment. Mycobacteria may be removed by multi-barrier treatment systems that combine processes such as coagulation, settling and disinfection. This work evaluated removal of a non-tuberculous Mycobacterium (Mycobaterium terrae) and a Gram-negative non-acid-fast environmental bacterium (Aeromonas hydrophila) by combined coagulation-flocculation disinfection POU treatment. Aeromonas hydrophila showed 7.7 log10 reduction in demand free buffer, 6.8 log10 in natural surface water, and 4 log10 reduction in fecally contaminated surface water. Turbidity after treatment was <1 NTU. There was almost no reduction in levels of viable M. terrae by coagulant-flocculant-disinfectant in natural water after 30 minutes. The lack of Mycobacteria reduction was similar for both combined coagulant-flocculant-disinfectant and hypochlorite alone. A POU coagulant-flocculant-disinfectant treatment effectively reduced A. hydrophila from natural surface waters but not Mycobacteria. These results reinforce previous findings that POU coagulation-flocculation-disinfection is effective against gram-negative enteric bacteria. POU treatment and safe storage interventions may need to take into account risks from viable NTM in treated stored water and consider alternative treatment processes to achieve NTM reductions. PMID:26580632

  9. Reduction of Acid-Fast and Non-Acid-Fast Bacteria by Point of Use Coagulation-Flocculation-Disinfection.

    PubMed

    Casanova, Lisa M; Sobsey, Mark D

    2015-11-01

    Point of use (POU) household water treatment is increasingly being adopted as a solution for access to safe water. Non-tuberculous Mycobacteria (NTM) are found in water, but there is little research on whether NTM survive POU treatment. Mycobacteria may be removed by multi-barrier treatment systems that combine processes such as coagulation, settling and disinfection. This work evaluated removal of a non-tuberculous Mycobacterium (Mycobaterium terrae) and a Gram-negative non-acid-fast environmental bacterium (Aeromonas hydrophila) by combined coagulation-flocculation disinfection POU treatment. Aeromonas hydrophila showed 7.7 log10 reduction in demand free buffer, 6.8 log10 in natural surface water, and 4 log10 reduction in fecally contaminated surface water. Turbidity after treatment was <1 NTU. There was almost no reduction in levels of viable M. terrae by coagulant-flocculant-disinfectant in natural water after 30 minutes. The lack of Mycobacteria reduction was similar for both combined coagulant-flocculant-disinfectant and hypochlorite alone. A POU coagulant-flocculant-disinfectant treatment effectively reduced A. hydrophila from natural surface waters but not Mycobacteria. These results reinforce previous findings that POU coagulation-flocculation-disinfection is effective against gram-negative enteric bacteria. POU treatment and safe storage interventions may need to take into account risks from viable NTM in treated stored water and consider alternative treatment processes to achieve NTM reductions. PMID:26580632

  10. [Characteristics of intranuclear inclusions formed during the reproduction of bovine adenoviruses].

    PubMed

    Nosach, L N; Belousova, R V; Diachenko, N S; Kolenkova, L M

    1986-01-01

    A cytomorphological method was used to study the reproduction of bovine adenoviruses: Ad bos 1 - Ad bos 3, belonging to the serological subgroup I, and Ad bos 4, Ad bos 5, Ad bos 7, Ad bos 8, belonging to the serological subgroup II, and those isolated from animal adenoviruses N18 and N3056. Cytomorphological method is supposed to be used not only for revealing bovine adenoviruses but also for determining preliminarily their subgroup belonging. PMID:3754069

  11. Intranuclear localization and UV response of ERCC5/XPG protein

    SciTech Connect

    Park, M.S.; Marrone, B.L.; MacInnes, M.A.

    1995-11-01

    The human ERCC5/XPG protein is defective in the hereditary genetic disorder xeroderma pigmentosum, group-G. The XPG gene encodes a single-strand DNA endonuclease which is essential for the incision step of nucleotide excision repair for a wide variety of DNA damages. We have shown previously by indirect immunofluorescence and biochemical fractionation that the XPG protein is localized in the nucleus, in discrete foci, and probably associated with the nuclear matrix. However, the intranuclear localization of XPG is markedly altered for a short time after UV irradiation. Here, we report the identification of XPG protein regions involved in the UV response, and its putative nuclear localization signals (NLS) using a B-galactosidase (B-gal) reporter gene system. Control and fusion reporter genes were expressed in Hela S3 cells after CaPO{sub 4} transfection. B-gal protein was detected by indirect immuno-fluorescence using an anti B-gal monoclonal antibody and FITC-labeled goat anti-mouse antiserum. Two NLS peptides of the XPG carboxy-terminal region (AA 1029-1069 and 1146-1186 term) were shown to independently localize B-gal fusion proteins to the nucleus (>90%). The C-terminus peptide was observed to further localize B-gal into nuclear foci and the perinucleolar regions. When B-gal was fused with two copies of the C-terminal NLS, in tandem, B-gal was extensively sublocalized to the perinucleolar regions. Shortly after cell UV irradiation (5 J/m{sup 2}) this B-gal fusion protein became dissociated from the perinucleolar regions whereupon it was distributed throughout the nucleus. Within 6 hours post-irradiation, the fusion protein reassociated again with the perinucleolar regions. These observations confirm and extend a similar UV response of endogenous XPG protein in UV-irradiation human cells. The involvement of XPG protein and its UV responses will be discussed in context of models nuclear matrix and preferential DNA repair in actively transcribed genes.

  12. ACID-FAST BACTERIA AND YEASTS AS INDICATORS OF DISINFECTION EFFICIENCY

    EPA Science Inventory

    Since the coliform group of organisms is considered to be less resistant to chlorine than some bacterial and viral pathogens, the utility of both yeast and acid-fast oganisms as potntial indicators of disinfection efficiency was evaluated. In most laboratory studies these two gro...

  13. Nucleosome-like structural subunits of intranuclear parental adenovirus type 2 DNA.

    PubMed Central

    Sergeant, A; Tigges, M A; Raskas, H J

    1979-01-01

    The intranuclear structure of parental adenovirus 2 DNA was studied using digestion with micrococcal nuclease as a probe. When cultures were infected with 32P-labeled virions, at a multiplicity of 3,000 particles per cell, 14 to 21% of parental DNA penetrated the cell and reached the nucleus. Of this parental DNA, 60% could be solubilized by extensive digestion with micrococcal nuclease. The nuclease-resistant fraction contained viral deoxyribonucleoprotein monomers and oligomers. These nucleosome-like structures contained DNA fragments which are integral multiples of a unit-length DNA of approximately 185 base pairs. The monomeric DNA is similar in length to the unit-length DNA contained in cellular nucleosomes. However, the viral oligomers are slightly smaller than their cellular counterparts. DNA-DNA hybridization demonstrated that all segments of the viral genome, including those expressed as mRNA only at late times, are represented in the nucleosomal viral DNA. The amount of early intranuclear viral chromatin was proportional to multiplicity of infection up to multiplicities of 4,000 particles per cell. However, viral transcriptional activity did not increase in direct proportion to the amount of viral chromatin. Maximum accumulation of intranuclear viral chromatin was achieved by 3 h after infection. The intranuclear parental viral chromatin remained resistant to nuclease digestion even at late times in infection, after viral DNA replication had begun. Images PMID:448800

  14. Disruption of NAD+ binding site in glyceraldehyde 3-phosphate dehydrogenase affects its intranuclear interactions

    PubMed Central

    Phadke, Manali; Krynetskaia, Natalia; Mishra, Anurag; Barrero, Carlos; Merali, Salim; Gothe, Scott A; Krynetskiy, Evgeny

    2015-01-01

    AIM: To characterize phosphorylation of human glyceraldehyde 3-phosphate dehydrogenase (GAPDH), and mobility of GAPDH in cancer cells treated with chemotherapeutic agents. METHODS: We used proteomics analysis to detect and characterize phosphorylation sites within human GAPDH. Site-specific mutagenesis and alanine scanning was then performed to evaluate functional significance of phosphorylation sites in the GAPDH polypeptide chain. Enzymatic properties of mutated GAPDH variants were assessed using kinetic studies. Intranuclear dynamics parameters (diffusion coefficient and the immobile fraction) were estimated using fluorescence recovery after photobleaching (FRAP) experiments and confocal microscopy. Molecular modeling experiments were performed to estimate the effects of mutations on NAD+ cofactor binding. RESULTS: Using MALDI-TOF analysis, we identified novel phosphorylation sites within the NAD+ binding center of GAPDH at Y94, S98, and T99. Using polyclonal antibody specific to phospho-T99-containing peptide within GAPDH, we demonstrated accumulation of phospho-T99-GAPDH in the nuclear fractions of A549, HCT116, and SW48 cancer cells after cytotoxic stress. We performed site-mutagenesis, and estimated enzymatic properties, intranuclear distribution, and intranuclear mobility of GAPDH mutated variants. Site-mutagenesis at positions S98 and T99 in the NAD+ binding center reduced enzymatic activity of GAPDH due to decreased affinity to NAD+ (Km = 741 ± 257 μmol/L in T99I vs 57 ± 11.1 µmol/L in wild type GAPDH. Molecular modeling experiments revealed the effect of mutations on NAD+ binding with GAPDH. FRAP (fluorescence recovery after photo bleaching) analysis showed that mutations in NAD+ binding center of GAPDH abrogated its intranuclear interactions. CONCLUSION: Our results suggest an important functional role of phosphorylated amino acids in the NAD+ binding center in GAPDH interactions with its intranuclear partners. PMID:26629320

  15. Case report: epithelial intracytoplasmic herpes viral inclusions associated with an outbreak of duck virus enteritis

    USGS Publications Warehouse

    Barr, B.C.; Jessup, David A.; Docherty, Douglas E.; Lownestine, L.J.

    1992-01-01

    Several muscovy ducks from a free-roaming flock of 65 muscovy and mallard ducks died over a 3-week period. Three muscovy ducks were necropsied. Gross and microscopic changes were compatible with duck virus enteritis, and the virus was isolated. In addition to intranuclear viral inclusion bodies in several tissues, intracytoplasmic inclusion bodies were present in esophageal and cloacal epithelium, By electron microscopy, the membrane-bound intracytoplasmic inclusions were found to contain enveloped herpesvirus, and nuclei contained herpes viral nucleocapsids.

  16. Nucleospora cyclopteri n. sp., an intranuclear microsporidian infecting wild lumpfish, Cyclopterus lumpus L., in Icelandic waters

    PubMed Central

    2013-01-01

    Background Commercial fisheries of lumpfish Cyclopterus lumpus have been carried out in Iceland for centuries. Traditionally the most valuable part is the eggs which are harvested for use as a caviar substitute. Previously reported parasitic infections from lumpfish include an undescribed intranuclear microsporidian associated with abnormal kidneys and mortalities in captive lumpfish in Canada. During Icelandic lumpfish fisheries in spring 2011, extensive enlargements to the kidneys were observed in some fish during processing. The aim of this study was to identify the pathogen responsible for these abnormalities. Methods Lumpfish from the Icelandic coast were examined for the causative agent of kidney enlargement. Fish were dissected and used in histological and molecular studies. Results Lumpfish, with various grades of clinical signs, were observed at 12 of the 43 sites sampled around Iceland. From a total of 77 fish examined, 18 had clear clinical signs, the most prominent of which was an extensive enlargement and pallor of the kidneys. The histopathology of the most severely affected fish consisted of extensive degeneration and necrosis of kidney tubules and vacuolar degeneration of the haematopoietic tissue. Intranuclear microsporidians were detected in all organs examined in fish with prominent clinical signs and most organs of apparently healthy fish using the new PCR and histological examination. One or multiple uniformly oval shaped spores measuring 3.12 ± 0.15 × 1.30 ± 0.12 μm were observed in the nucleus of affected lymphocytes and lymphocyte precursor cells. DNA sequencing provided a ribosomal DNA sequence that was strongly supported in phylogenetic analyses in a clade containing other microsporidian parasites from the Enterocytozoonidae, showing highest similarity to the intranuclear microsporidian Nucleospora salmonis. Conclusions Intranuclear microsporidian infections are common in wild caught lumpfish from around the Icelandic

  17. INTRANUCLEAR MATRIX METALLOPROTEINASES PROMOTE DNA DAMAGE AND APOPTOSIS INDUCED BY OXYGEN–GLUCOSE DEPRIVATION IN NEURONS

    PubMed Central

    HILL, J. W.; PODDAR, R.; THOMPSON, J. F.; ROSENBERG, G. A.; YANG, Y.

    2016-01-01

    Degradation of the extracellular matrix by elevated matrix metalloproteinase (MMP) activity following ischemia/reperfusion is implicated in blood–brain barrier disruption and neuronal death. In contrast to their characterized extracellular roles, we previously reported that elevated intranuclear MMP-2 and -9 (gelatinase) activity degrades nuclear DNA repair proteins and promotes accumulation of oxidative DNA damage in neurons in rat brain at 3-h reperfusion after ischemic stroke. Here, we report that treatment with a broad-spectrum MMP inhibitor significantly reduced neuronal apoptosis in rat ischemic hemispheres at 48-h reperfusion after a 90-min middle cerebral artery occlusion (MCAO). Since extracellular gelatinases in brain tissue are known to be neurotoxic during acute stroke, the contribution of intranuclear MMP-2 and -9 activities in neurons to neuronal apoptosis has been unclear. To confirm and extend our in vivo observations, oxygen–glucose deprivation (OGD), an in vitro model of ischemia/reperfusion, was employed. Primary cortical neurons were subjected to 2-h OGD with reoxygenation. Increased intranuclear gelatinase activity was detected immediately after reoxygenation onset and was maximal at 24 h, while extracellular gelatinase levels remained unchanged. We detected elevated levels of both MMP-2 and -9 in neuronal nuclear extracts and gelatinase activity in neurons co-localized primarily with MMP-2. We found a marked decrease in PARP1, XRCC1, and OGG1, and decreased PARP1 activity. Pretreatment of neurons with selective MMP-2/9 inhibitor II significantly decreased gelatinase activity and downregulation of DNA repair enzymes, decreased accumulation of oxidative DNA damage, and promoted neuronal survival after OGD. Our results confirm the nuclear localization of gelatinases and their nuclear substrates observed in an animal stroke model, further supporting a novel role for intranuclear gelatinase activity in an intrinsic apoptotic pathway in neurons

  18. The intranuclear mobility of messenger RNA binding proteins is ATP dependent and temperature sensitive

    PubMed Central

    Calapez, Alexandre; Pereira, Henrique M.; Calado, Angelo; Braga, José; Rino, José; Carvalho, Célia; Tavanez, João Paulo; Wahle, Elmar; Rosa, Agostinho C.; Carmo-Fonseca, Maria

    2002-01-01

    fAter being released from transcription sites, messenger ribonucleoprotein particles (mRNPs) must reach the nuclear pore complexes in order to be translocated to the cytoplasm. Whether the intranuclear movement of mRNPs results largely from Brownian motion or involves molecular motors remains unknown. Here we have used quantitative photobleaching techniques to monitor the intranuclear mobility of protein components of mRNPs tagged with GFP. The results show that the diffusion coefficients of the poly(A)-binding protein II (PABP2) and the export factor TAP are significantly reduced when these proteins are bound to mRNP complexes, as compared with nonbound proteins. The data further show that the mobility of wild-type PABP2 and TAP, but not of a point mutant variant of PABP2 that fails to bind to RNA, is significantly reduced when cells are ATP depleted or incubated at 22°C. Energy depletion has only minor effects on the intranuclear mobility of a 2,000-kD dextran (which corresponds approximately in size to 40S mRNP particles), suggesting that the reduced mobility of PABP2 and TAP is not caused by a general alteration of the nuclear environment. Taken together, the data suggest that the mobility of mRNPs in the living cell nucleus involves a combination of passive diffusion and ATP-dependent processes. PMID:12473688

  19. Pulmonary neuroendocrine tumors with nuclear inclusion.

    PubMed

    Kobayashi, Saori; Tsuta, Koji; Sekine, Shigeki; Yoshida, Akihiko; Sasaki, Naoshi; Shibuki, Yasuo; Sakurai, Hiroyuki; Watanabe, Shun-Ichi; Asamura, Hisao; Tsuda, Hitoshi

    2013-09-01

    Nuclear inclusion or pseudoinclusion is a peculiar cytological feature, and its recognition in appropriate clinicopathological settings can aid in the diagnosis of several disease entities. To the best of our knowledge, only 1 case of pulmonary neuroendocrine tumor (NET) with nuclear pseudoinclusion has been reported. A review of 227 patients who had undergone surgical resection for pulmonary NETs revealed 2 tumors with different mechanisms of nuclear inclusion. To explore the cause of nuclear inclusion, NET with nuclear inclusion was characterized immunohistochemically and ultrastructurally. Nuclear inclusions were observed in 2 of the 227 (0.9%) patients with pulmonary NETs. The first patient was a 46-year-old woman with small cell carcinoma. Tumor cells with nuclear inclusions were distributed focally. Ultrastructural analysis showed that these inclusions were pseudoinclusions. The second patient was a 62-year-old man with large-cell neuroendocrine carcinoma. Nuclear inclusions were observed in the focal area of the tumor. Immunohistochemical analysis revealed that the intra-nuclear materials consisted of biotin and aberrant cytoplasmic and nuclear accumulation of β-catenin. Mutational analysis revealed a CTNNB1 gene mutation. Although very rare, diagnostic errors may be observed in cases of pulmonary NETs with nuclear inclusions. The mechanisms of nuclear inclusion differed, with one due to herniation of the cytoplasm into the nucleus (pseudoinclusion) and the other due to accumulation of biotin resulting from a CTNNB1 gene mutation. PMID:23896262

  20. Phosphorylation of KasB Regulates Virulence and Acid-Fastness in Mycobacterium tuberculosis

    PubMed Central

    Vilchèze, Catherine; Molle, Virginie; Carrère-Kremer, Séverine; Leiba, Jade; Mourey, Lionel; Shenai, Shubhada; Baronian, Grégory; Tufariello, Joann; Hartman, Travis; Veyron-Churlet, Romain; Trivelli, Xavier; Tiwari, Sangeeta; Weinrick, Brian; Alland, David; Guérardel, Yann; Jacobs, William R.; Kremer, Laurent

    2014-01-01

    Mycobacterium tuberculosis bacilli display two signature features: acid-fast staining and the capacity to induce long-term latent infections in humans. However, the mechanisms governing these two important processes remain largely unknown. Ser/Thr phosphorylation has recently emerged as an important regulatory mechanism allowing mycobacteria to adapt their cell wall structure/composition in response to their environment. Herein, we evaluated whether phosphorylation of KasB, a crucial mycolic acid biosynthetic enzyme, could modulate acid-fast staining and virulence. Tandem mass spectrometry and site-directed mutagenesis revealed that phosphorylation of KasB occurred at Thr334 and Thr336 both in vitro and in mycobacteria. Isogenic strains of M. tuberculosis with either a deletion of the kasB gene or a kasB_T334D/T336D allele, mimicking constitutive phosphorylation of KasB, were constructed by specialized linkage transduction. Biochemical and structural analyses comparing these mutants to the parental strain revealed that both mutant strains had mycolic acids that were shortened by 4–6 carbon atoms and lacked trans-cyclopropanation. Together, these results suggested that in M. tuberculosis, phosphorylation profoundly decreases the condensing activity of KasB. Structural/modeling analyses reveal that Thr334 and Thr336 are located in the vicinity of the catalytic triad, which indicates that phosphorylation of these amino acids would result in loss of enzyme activity. Importantly, the kasB_T334D/T336D phosphomimetic and deletion alleles, in contrast to the kasB_T334A/T336A phosphoablative allele, completely lost acid-fast staining. Moreover, assessing the virulence of these strains indicated that the KasB phosphomimetic mutant was attenuated in both immunodeficient and immunocompetent mice following aerosol infection. This attenuation was characterized by the absence of lung pathology. Overall, these results highlight for the first time the role of Ser/Thr kinase

  1. Compartmentalization and Functionality of Nuclear Disorder: Intrinsic Disorder and Protein-Protein Interactions in Intra-Nuclear Compartments

    PubMed Central

    Meng, Fanchi; Na, Insung; Kurgan, Lukasz; Uversky, Vladimir N.

    2015-01-01

    The cell nucleus contains a number of membrane-less organelles or intra-nuclear compartments. These compartments are dynamic structures representing liquid-droplet phases which are only slightly denser than the bulk intra-nuclear fluid. They possess different functions, have diverse morphologies, and are typically composed of RNA (or, in some cases, DNA) and proteins. We analyzed 3005 mouse proteins localized in specific intra-nuclear organelles, such as nucleolus, chromatin, Cajal bodies, nuclear speckles, promyelocytic leukemia (PML) nuclear bodies, nuclear lamina, nuclear pores, and perinuclear compartment and compared them with ~29,863 non-nuclear proteins from mouse proteome. Our analysis revealed that intrinsic disorder is enriched in the majority of intra-nuclear compartments, except for the nuclear pore and lamina. These compartments are depleted in proteins that lack disordered domains and enriched in proteins that have multiple disordered domains. Moonlighting proteins found in multiple intra-nuclear compartments are more likely to have multiple disordered domains. Protein-protein interaction networks in the intra-nuclear compartments are denser and include more hubs compared to the non-nuclear proteins. Hubs in the intra-nuclear compartments (except for the nuclear pore) are enriched in disorder compared with non-nuclear hubs and non-nuclear proteins. Therefore, our work provides support to the idea of the functional importance of intrinsic disorder in the cell nucleus and shows that many proteins associated with sub-nuclear organelles in nuclei of mouse cells are enriched in disorder. This high level of disorder in the mouse nuclear proteins defines their ability to serve as very promiscuous binders, possessing both large quantities of potential disorder-based interaction sites and the ability of a single such site to be involved in a large number of interactions. PMID:26712748

  2. Adenovirus-like inclusion body hepatitis in a flock of broiler chickens in Kermanshah province, Iran

    PubMed Central

    Rahimi, Morad; Minoosh Siavosh Haghighi, Zahra

    2015-01-01

    Inclusion body hepatitis (IBH) has been reported in many countries in the world. The IBH or similar cases characterized by hepatitis and presence of intra-nuclear inclusion bodies in hepatocytes have not been reported in broiler chickens in Iran. This is the first report on outbreak of adenovirus-like inclusion body hepatitis in Iran. On October 2012, an onset of high acute mortality in a flock of 2 day-old broiler chickens was reported to the Veterinary Clinic, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran. The birds showed lethargy, huddling, ruffled feathers, and inappetence. At necropsy the livers were the primary organ affected which were enlarged, pale yellow with necrotic foci and multiple petechial hemorrhages. Tissue samples of liver, kidneys and heart were fixed in 10% buffered formalin. They were processed and stained with hematoxylin and eosin for histopathological studies. Significant microscopic lesions were seen in the livers. Large eosinophilic intra-nuclear inclusion bodies were seen in hepatocytes. Based on the acute high mortality, age of the broilers, gross lesions and histopathological findings (especially intra-nuclear inclusion bodies), the condition was diagnosed as adenovirus-like inclusion body hepatitis. PMID:25992259

  3. The Inclusive Classroom: How Inclusive Is Inclusion?

    ERIC Educational Resources Information Center

    Reid, Claudette M.

    2010-01-01

    This paper presents the position that inclusion is limited; inclusion does not go far enough. The inclusive classroom has been assessed to be of benefit both to the teacher and student. There are, however, limits set on inclusion. In most classrooms only children with learning disability are included omitting those with severe disabilities,…

  4. Widespread occurrence of an intranuclear bacterial parasite in vent and seep bathymodiolin mussels.

    PubMed

    Zielinski, Frank U; Pernthaler, Annelie; Duperron, Sébastien; Raggi, Luciana; Giere, Olav; Borowski, Christian; Dubilier, Nicole

    2009-05-01

    Many parasitic bacteria live in the cytoplasm of multicellular animals, but only a few are known to regularly invade their nuclei. In this study, we describe the novel bacterial parasite "Candidatus Endonucleobacter bathymodioli" that invades the nuclei of deep-sea bathymodiolin mussels from hydrothermal vents and cold seeps. Bathymodiolin mussels are well known for their symbiotic associations with sulfur- and methane-oxidizing bacteria. In contrast, the parasitic bacteria of vent and seep animals have received little attention despite their potential importance for deep-sea ecosystems. We first discovered the intranuclear parasite "Ca. E. bathymodioli" in Bathymodiolus puteoserpentis from the Logatchev hydrothermal vent field on the Mid-Atlantic Ridge. Using primers and probes specific to "Ca. E. bathymodioli" we found this intranuclear parasite in at least six other bathymodiolin species from vents and seeps around the world. Fluorescence in situ hybridization and transmission electron microscopy analyses of the developmental cycle of "Ca. E. bathymodioli" showed that the infection of a nucleus begins with a single rod-shaped bacterium which grows to an unseptated filament of up to 20 microm length and then divides repeatedly until the nucleus is filled with up to 80,000 bacteria. The greatly swollen nucleus destroys its host cell and the bacteria are released after the nuclear membrane bursts. Intriguingly, the only nuclei that were never infected by "Ca. E. bathymodioli" were those of the gill bacteriocytes. These cells contain the symbiotic sulfur- and methane-oxidizing bacteria, suggesting that the mussel symbionts can protect their host nuclei against the parasite. Phylogenetic analyses showed that the "Ca. E. bathymodioli" belongs to a monophyletic clade of Gammaproteobacteria associated with marine metazoans as diverse as sponges, corals, bivalves, gastropods, echinoderms, ascidians and fish. We hypothesize that many of the sequences from this clade

  5. Inclusion body disease (herpesvirus infection) of falcons (IBDF).

    PubMed

    Graham, D L; Mare, C J; Ward, F P; Peckham, M C

    1975-01-01

    Inclusion body disease of falcons (IBDF) is caused by a herpesvirus. The clinical course is short, 24 to 72 hours in duration, and is characterized by mild to severe depression and weakness often accompanied by anorexia. The disease is invariably fatal. The virus has a marked affinity for the reticuloendothelial system and hepatocytes,producing focal to diffuse necrosis of infected tissues accompanied by the formation of intranuclear inclusion bodies. The virus is pathogenic for American kestrels (Falco sparverius) and great horned owls (Bubo virginianus) in which typical lesions of IBDF are reproduced. The lesions of IBDF are similar to those produced by some herpesvirus infections in other avian species. PMID:163383

  6. Protein complex formation and intranuclear dynamics of NAC1 in cancer cells.

    PubMed

    Nakayama, Naomi; Kato, Hiroaki; Sakashita, Gyosuke; Nariai, Yuko; Nakayama, Kentaro; Kyo, Satoru; Urano, Takeshi

    2016-09-15

    Nucleus accumbens-associated protein 1 (NAC1) is a cancer-related transcription regulator protein that is also involved in the pluripotency and differentiation of embryonic stem cells. NAC1 is overexpressed in various carcinomas including ovarian, cervical, breast, and pancreatic carcinomas. NAC1 knock-down was previously shown to result in the apoptosis of ovarian cancer cell lines and to rescue their sensitivity to chemotherapy, suggesting that NAC1 may be a potential therapeutic target, but protein complex formation and the dynamics of intranuclear NAC1 in cancer cells remain poorly understood. In this study, analysis of HeLa cell lysates by fast protein liquid chromatography (FPLC) on a sizing column showed that the NAC1 peak corresponded to an apparent molecular mass of 300-500 kDa, which is larger than the estimated molecular mass (58 kDa) of the protein. Furthermore, live cell photobleaching analyses with green fluorescent protein (GFP)-fused NAC1 proteins revealed the intranuclear dynamics of NAC1. Collectively our results demonstrate that NAC1 forms a protein complex to function as a transcriptional regulator in cancer cells. PMID:27424155

  7. Hypoxic ischemic encephalopathy in a case of intranuclear rod myopathy without any prenatal sentinel event.

    PubMed

    Kawase, Koya; Nishino, Ichizo; Sugimoto, Mari; Kouwaki, Masanori; Koyama, Norihisa; Yokochi, Kenji

    2015-02-01

    Intranuclear rod myopathy (IRM), a variant of nemaline myopathy, is characterized by the presence of nemaline bodies in myonuclei. We report a case of IRM presenting with hypoxic ischemic encephalopathy (HIE). There were no prenatal complications caused by fetal brain injury. Although no nemaline bodies were observed in the cytoplasm, intranuclear rods were observed in some fibers under light and electron microscopy. Molecular analysis identified a heterozygous variant, c.449C>T (p.Thr150Ile), in ACTA1. On magnetic resonance imaging at 9days of age, injuries to the basal ganglia, thalamus, and brainstem consistent with perinatal HIE were seen. Respiratory insufficiency at birth was strongly suspected to be the cause of HIE. Our case highlights that a patient with a congenital neuromuscular disorder who presents with severe respiratory dysfunction requiring substantial resuscitative efforts at birth can be complicated by HIE without any prenatal sentinel event. Prenatal detection of neuromuscular disorders, careful management of delivery, and neonatal resuscitation and adequate respiratory management are important in preventing irreversible brain injury in these patients. PMID:24787270

  8. Accessing the tonotopic organization of the ventral cochlear nucleus by intranuclear microstimulation.

    PubMed

    McCreery, D B; Shannon, R V; Moore, J K; Chatterjee, M

    1998-12-01

    This study is part of a program to develop an auditory prosthesis for the profoundly deaf, based on multichannel microstimulation in the cochlear nucleus. The functionality of such a device is dependent on its ability to access the tonotopic axis of the human ventral cochlear nucleus in an orderly fashion. In these studies, we utilized the homologies between the human and feline ventral cochlear nuclei and the known tonotopic organization of the central nucleus of the inferior colliculus (IC). In anesthetized cats, stimuli were delivered to three or four locations along the dorsal-to-ventral axis of the posteroventral cochlear nucleus (PVCN), and for each stimulus location, we recorded the multiunit neuronal activity and the field potentials at 20 or more locations along the dorsolateral-ventromedial (tonotopic) axis of the IC. The current source-sink density (CSD), which delimits regions of neuronal activity, was computed from the sequence of field potentials recorded along this axis. The multiunit activity and the CSD analysis both showed that the tonotopic organization of the PVCN can be accessed in an orderly manner by intranuclear microstimulation in several regions of the PVCN, using the range of stimulus pulse amplitudes that have been shown in previous studies to be noninjurious during prolonged intranuclear microstimulation via chronically implanted microelectrodes. We discuss the applicability of these findings to the design of clinical auditory prostheses for implantation into the human cochlear nucleus. PMID:9865886

  9. Extended Intranuclear Cascade model for pickup reactions induced by 50-MeV-range protons

    NASA Astrophysics Data System (ADS)

    Uozumi, Yusuke; Mori, Taiki; Sonoda, Akifumi; Nakano, Masahiro

    2016-06-01

    The intranuclear cascade model was investigated to explain (p, dx) and (p, ax) reactions at incident energies of around 50 MeV. Since these reactions are governed mainly by the direct pickup process, the model was expanded to include exclusive pickup processes leading to hole-state-excitations. The energy of the outgoing clusters is determined with single-particle energies of transferred nucleons, the reaction Q-value, and the recoil of the residual nucleus. The rescattering of the produced cluster inside the nucleus is treated within the intranuclear cascade model. The emission angle is given by the sum of momentum vectors of transferred nucleons in addition to the deflection at the nuclear surface, which was introduced to explain angular distributions of elastic scattering. Double differential cross sections of reactions were calculated and compared with experimental data. The proposed model showed a high predictive power over the wide range of emission energies and angles. The treatment ofthe cluster transport inside the nucleus was also verified.

  10. Inclusive pion double charge exchange in light p-shell nuclei

    SciTech Connect

    Fong, W.; Matthews, J. L.; Dowell, M. L.; Kinney, E. R.; Soos, T.; Wang, M. Y.; Wood, S. A.; Gram, P. A. M.; Rebka, G. A. Jr.; Roberts, D. A.

    2007-06-15

    We report the results of a series of measurements of the differential cross sections for inclusive pion double charge exchange in {sup 6,7}Li, {sup 9}Be, and {sup 12}C for positive and negative incident pions of energies 120, 180, and 240 MeV. The data are compared with the predictions of an intranuclear cascade model and a model based on two sequential single charge exchange processes.

  11. Characteristics of endobronchial tuberculosis patients with negative sputum acid-fast bacillus

    PubMed Central

    Yıldız, Pınar

    2013-01-01

    Objective Endobronchial tuberculosis (EBTB) is defined as a tuberculous infection of the tracheobronchial tree with microbial and histopathological evidence, with or without parenchymal involvement. In this study, clinical, radiological and bronchoscopic characteristics of cases diagnosed to have EBTB were evaluated. Methods Sixteen patients with at least three negative sputum examinations for acid-fast bacillus (AFB) and diagnosed as having EBTB on the histopathological examination of bronchoscopically obtained specimens showing granulomatous structures with caseation necrosis and/or positive AFB-culture on the microbiological examination of bronchoscopically obtained specimens were included in our study. Age, sex, symptoms, tuberculin skin test (TST), microbiological examination results and radiological findings were recorded. Bronchoscopical lesions were classified according to Chung classification. Results EBTB was found to be more common in females. Most common symptoms were cough (100%), sputum (75%), weight loss (62.5%), hemoptisis (37.5%), chest pain (25%) and dyspnea (12.5%). Radiological examination findings revealed consolidations/infiltrations (87.5%), nodular lesions (37.5%), cavitary lesions (25%), unilateral (43.7%) or bilateral hilar widening (31.2%) and atelectasia (25%). Middle lob syndrome was seen in three cases. Most common lesions observed bronchoscopically were active caseous lesions, granular lesions, edematous hyperemic lesions, tumorous lesions, fibrostenotic lesions respectively. In all cases “granulomatous inflammation showing caseation” was shown in the histopathological examination of biopsy specimens. Conclusions EBTB can cause various radiological and bronchoscopical findings. In most of the cases distinct response is seen to antituberculous treatment. Bronchial stenosis is an important complication. Treatment should be given as soon as possible to avoid it. PMID:24409353

  12. Mistaken identity: Legionella micdadei appearing as acid fast bacilli on lung biopsy of a hematopoietic stem cell transplant patient

    PubMed Central

    Waldron, Paul Ravi; Martin, Brock A.; Ho, Dora Y.

    2015-01-01

    Legionella micdadei is a potential cause of invasive lung infections in immunocompromised hosts. On biopsy specimens, it can appear as an acid-fast bacillus (AFB) and can be mistaken for a member of genus Mycobacterium. As Legionella requires selective media to grow in culture, and a commonly used, commercially available urine antigen test for Legionella only detects Legionella pneumophila serogroup 1 but not L. micdadei, it is important to consider this organism in the differential diagnosis for AFB in immunocompromised hosts. We report a case of Legionella micdadei infection, which was initially treated empirically for non-tuberculous mycobacteria based on acid fast staining of biopsy tissue before the final diagnosis was made. PMID:25573597

  13. Demonstration of acid-fast bacilli in buffy coat and bone marrow smear--a diagnostic tool in pulmonary tuberculosis.

    PubMed

    Sen, R; Singh, S; Singh, H P; Sen, J; Yadav, M S; Arora, B R

    1996-10-01

    Buffy coat smears prepared from peripheral blood and bone marrow aspirate obtained from proved 60 untreated cases of pulmonary tuberculosis were stained with Ziehl-Neelsen method and thoroughly screened for presence of tubercle bacilli. Acid-fast bacilli were detected in 55% cases in buffy coat, 48.3% cases in bone marrow, 38.3% cases both in buffy coat and bone marrow and 65% cases either in buffy coat or in bone marrow or in both. Considering the fact that demonstration of acid-fast bacilli may not be possible in more than 25-50% of the suspected cases of tuberculosis, these techniques are recommended for evaluation of their utility in establishing diagnosis of tuberculosis, particularly in reference to sputum negative cases of pulmonary tuberculosis and tuberculosis of inaccessible extrapulmonary sites. PMID:9141877

  14. Intranuclear interactomic inhibition of NF-κB suppresses LPS-induced severe sepsis

    SciTech Connect

    Park, Sung-Dong; Cheon, So Yeong; Park, Tae-Yoon; Shin, Bo-Young; Oh, Hyunju; Ghosh, Sankar; Koo, Bon-Nyeo; Lee, Sang-Kyou

    2015-08-28

    Suppression of nuclear factor-κB (NF-κB) activation, which is best known as a major regulator of innate and adaptive immune responses, is a potent strategy for the treatment of endotoxic sepsis. To inhibit NF-κB functions, we designed the intra-nuclear transducible form of transcription modulation domain (TMD) of RelA (p65), called nt-p65-TMD, which can be delivered effectively into the nucleus without influencing the cell viability, and work as interactomic inhibitors via disruption of the endogenous p65-mediated transcription complex. nt-p65-TMD effectively inhibited the secretion of pro-inflammatory cytokines, including TNF-α, IL-1β, or IL-6 from BV2 microglia cells stimulated by lipopolysaccharide (LPS). nt-p65-TMD did not inhibit tyrosine phosphorylation of signaling mediators such as ZAP-70, p38, JNK, or ERK involved in T cell activation, but was capable of suppressing the transcriptional activity of NF-κB without the functional effect on that of NFAT upon T-cell receptor (TCR) stimulation. The transduced nt-p65-TMD in T cell did not affect the expression of CD69, however significantly inhibited the secretion of T cell-specific cytokines such as IL-2, IFN-γ, IL-4, IL-17A, or IL-10. Systemic administration of nt-p65-TMD showed a significant therapeutic effect on LPS-induced sepsis model by inhibiting pro-inflammatory cytokines secretion. Therefore, nt-p65-TMD can be a novel therapeutics for the treatment of various inflammatory diseases, including sepsis, where a transcription factor has a key role in pathogenesis, and further allows us to discover new functions of p65 under normal physiological condition without genetic alteration. - Highlights: • The nt-p65-TMD is intra-nuclear interactomic inhibitor of endogenous p65. • The nt-p65-TMD effectively inhibited the secretion of pro-inflammatory cytokines. • The excellent therapeutic potential of nt-p65-TMD was confirmed in sepsis model.

  15. Processes involving few degrees of freedom in the frame of Intranuclear Cascade approaches

    NASA Astrophysics Data System (ADS)

    Cugnon, J.; Boudard, A.; David, J.-C.; Leray, S.; Mancusi, D.

    2016-05-01

    This article focuses on spallation reactions, i.e. interactions of energetic nucleons, basically with a kinetic energy in the 100MeV to a few GeV range, with a target nucleus. These processes are described rather successfully by the so-called Intranuclear Cascade (INC) plus evaporation models. They can be viewed as a first stage of nucleon-nucleon collisions, ejecting fast particles, followed by evaporation of slow particles from the target remnant. These cascade + evaporation models have, now, globally reached a high level of predictive power, owing in particular to successive research programs. The present work, which is an outcome of one of these programs, the recent European Union ANDES research program, deals with a set of reactions (or observable quantities), which can be due to a single collision, such as the one-nucleon removal reactions or the quasi-elastic elastic process. A survey of the experimental data is presented, which allows to clearly point out that, often, the INC models are unsatisfactory for the description of these peculiar events, whereas they are rather successful for the rest of the experimental data. This paradoxical situation is tentatively related to quasi-particle effects which are neglected in INC models.

  16. Intranuclear cascade with emission of light fragment code implemented in the transport code system PHITS

    NASA Astrophysics Data System (ADS)

    Sawada, Y.; Uozumi, Y.; Nogamine, S.; Yamada, T.; Iwamoto, Y.; Sato, T.; Niita, K.

    2012-11-01

    The Intranuclear Cascade with Emission of Light Fragment (INC-ELF) code has been developed and implemented in the Particle and Heavy Ion Transport code System (PHITS). The INC-ELF code explicitly includes nucleon correlations within the framework of the INC model to describe light fragment emissions from nuclear spallation reactions by using the model in Phys. Rev. C 84, (2011) 064617. In addition to the degrees of freedom of nucleons, the developed code also accounts for pions, Δs, and N∗s, and can cover energy ranges up to 3 GeV. The predictive capabilities of the ELF/PHITS system have been verified through comparison with a diverse set of experimental observations. In particular, the verification was conducted with abundant double-differential cross-section data covering a wide range of reactions (e.g., (p, p'x), (p, nx), (p, dx), (p, 3Hex), (p, αx) and (p, πx) reactions) over a wide energy range (between 400 MeV and 1.5 GeV). As a result, our ELF/PHITS code has demonstrated strong predictive capability for all of these data, although areas requiring future study remain due to the lack of experimental data on high-energy cluster production.

  17. Balbiani Ring mRNPs Diffuse through and Bind to Clusters of Large Intranuclear Molecular Structures

    PubMed Central

    Veith, Roman; Sorkalla, Thomas; Baumgart, Eugen; Anzt, Johannes; Häberlein, Hanns; Tyagi, Sanjay; Siebrasse, Jan Peter; Kubitscheck, Ulrich

    2010-01-01

    A detailed conception of intranuclear messenger ribonucleoprotein particle (mRNP) dynamics is required for the understanding of mRNP processing and gene expression outcome. We used complementary state-of-the-art fluorescence techniques to quantify native mRNP mobility at the single particle level in living salivary gland cell nuclei. Molecular beacons and fluorescent oligonucleotides were used to specifically label BR2.1 mRNPs by an in vivo fluorescence in situ hybridization approach. We characterized two major mobility components of the BR2.1 mRNPs. These components with diffusion coefficients of 0.3 ± 0.02 μm2/s and 0.73 ± 0.03 μm2/s were observed independently of the staining method and measurement technique used. The mobility analysis of inert tracer molecules revealed that the gland cell nuclei contain large molecular nonchromatin structures, which hinder the mobility of large molecules and particles. The mRNPs are not only hindered by these mobility barriers, but in addition also interact presumably with these structures, what further reduces their mobility and effectively leads to the occurrence of the two diffusion coefficients. In addition, we provide evidence that the remarkably high mobility of the large, 50 nm-sized BR2.1 mRNPs was due to the absence of retarding chromatin. PMID:20959109

  18. Autophagy-related intrinsically disordered proteins in intra-nuclear compartments.

    PubMed

    Na, Insung; Meng, Fanchi; Kurgan, Lukasz; Uversky, Vladimir N

    2016-08-16

    Recent analyses indicated that autophagy can be regulated via some nuclear transcriptional networks and many important players in the autophagy and other forms of programmed cell death are known to be intrinsically disordered. To this end, we analyzed similarities and differences in the intrinsic disorder distribution of nuclear and non-nuclear proteins related to autophagy. We also looked at the peculiarities of the distribution of the intrinsically disordered autophagy-related proteins in various intra-nuclear organelles, such as the nucleolus, chromatin, Cajal bodies, nuclear speckles, promyelocytic leukemia (PML) nuclear bodies, nuclear lamina, nuclear pores, and perinucleolar compartment. This analysis revealed that the autophagy-related proteins constitute about 2.5% of the non-nuclear proteins and 3.3% of the nuclear proteins, which corresponds to a substantial enrichment by about 32% in the nucleus. Curiously, although, in general, the autophagy-related proteins share similar characteristics of disorder with a generic set of all non-nuclear proteins, chromatin and nuclear speckles are enriched in the intrinsically disordered autophagy proteins (29 and 37% of these proteins are disordered, respectively) and have high disorder content at 0.24 and 0.27, respectively. Therefore, our data suggest that some of the nuclear disordered proteins may play important roles in autophagy. PMID:27377881

  19. A novel intranuclear RNA vector system for long-term stem cell modification.

    PubMed

    Ikeda, Y; Makino, A; Matchett, W E; Holditch, S J; Lu, B; Dietz, A B; Tomonaga, K

    2016-03-01

    Genetically modified stem and progenitor cells have emerged as a promising regenerative platform in the treatment of genetic and degenerative disorders, highlighted by their successful therapeutic use in inherent immunodeficiencies. However, biosafety concerns over insertional mutagenesis resulting from integrating recombinant viral vectors have overshadowed the widespread clinical applications of genetically modified stem cells. Here, we report an RNA-based episomal vector system, amenable for long-term transgene expression in stem cells. Specifically, we used a unique intranuclear RNA virus, borna disease virus (BDV), as the gene transfer vehicle, capable of persistent infections in various cell types. BDV-based vectors allowed for long-term transgene expression in mesenchymal stem cells (MSCs) without affecting cellular morphology, cell surface CD105 expression or the adipogenicity of MSCs. Similarly, replication-defective BDV vectors achieved long-term transduction of human induced pluripotent stem cells, while maintaining the ability to differentiate into three embryonic germ layers. Thus, the BDV-based vectors offer a genomic modification-free, episomal RNA delivery system for sustained stem cell transduction. PMID:26632671

  20. A novel intranuclear RNA vector system for long-term stem cell modification

    PubMed Central

    Ikeda, Yasuhiro; Makino, Akiko; Matchett, William E.; Holditch, Sara J.; Lu, Brian; Dietz, Allan B.; Tomonaga, Keizo

    2015-01-01

    Genetically modified stem and progenitor cells have emerged as a promising regenerative platform in the treatment of genetic and degenerative disorders, highlighted by their successful therapeutic use in inherent immunodeficiencies. However, biosafety concerns over insertional mutagenesis resulting from integrating recombinant viral vectors have overshadowed the widespread clinical applications of genetically modified stem cells. Here, we report an RNA-based episomal vector system, amenable for long-term transgene expression in stem cells. Specifically, we used a unique intranuclear RNA virus, Borna disease virus (BDV), as the gene transfer vehicle, capable of persistent infections in various cell types. BDV-based vectors allowed for long-term transgene expression in mesenchymal stem cells (MSCs) without affecting cellular morphology, cell surface CD105 expression, or the adipogenicity of MSCs. Similarly, replication-defective BDV vectors achieved long-term transduction of human induced pluripotent stem cells (iPSCs), while maintaining the ability to differentiate into three embryonic germ layers. Thus, the BDV-based vectors offer a genomic modification-free, episomal RNA delivery system for sustained stem cell transduction. PMID:26632671

  1. Topochemistry of Internuclear and Intranuclear Interneurons of the Vasomotor Area in the Medulla Oblongata of Hypertensive Rats.

    PubMed

    Chertok, V M; Kotsyuba, A E; Startseva, M S

    2016-01-01

    Immunohistochemical examination with the antiserum against neuronal NO synthase and cystathionine β-synthase was used to study the following two pools of interneurons in Wistar rats at various periods after the development of renovascular hypertension: intranuclear interneurons (lying in the projection of the solitary nucleus, reticular gigantocellular nucleus, and parvocellular nucleus) and 2 groups of internuclear interneurons (small interneurons, area 50-300 μ(2); and large interneurons, area above 350 μ(2)). Intranuclear and internuclear interneurons probably play a role in the central mechanisms of hemodynamics regulation. These interneurons differ by not only in topochemical parameters, but also functional properties (different resistances to BP changes). Intranuclear interneurons are characterized by high sensitivity of the gas transmitter systems to a continuous increase in BP, which results in remodeling and dysfunction of the bulbar part of the cardiovascular center. Large internuclear interneurons demonstrate a strong reaction to BP rise, which confirms their involvement into hemodynamics regulation. By contrast, small internuclear interneurons retain their characteristics in arterial hypertension and probably perform an integrative function. PMID:26746841

  2. Inclusive health.

    PubMed

    Maclachlan, Malcolm; Khasnabis, Chapal; Mannan, Hasheem

    2012-01-01

    We propose the concept of Inclusive Health to encapsulate the Health for All ethos; to build on the rights-based approach to health; to promote the idea of inclusion as a verb, where a more proactive approach to addressing distinctive and different barriers to inclusion is needed; and to recognise that new initiatives in human resources for health can offer exciting and innovative ways of healthcare delivery. While Inclusive Education has become a widely recognised and accepted concept, Health for All is still contested, and new thinking is required to develop its agenda in line with contemporary developments. Inclusive Health refers both to who gets health care and to who provides it; and its ethos resonates strongly with Jefferson's assertion that 'there is nothing more unequal, than the equal treatment of unequal people'. We situate the timeliness of the Inclusive Health concept with reference to recent developments in the recognition of the rights of people with disability, in the new guidelines for community-based rehabilitation and in the World Report on Disability. These developments offer a more inclusive approach to health and, more broadly, its inter-connected aspects of wellbeing. A concept which more proactively integrates United Nations conventions that recognise the importance of difference - disability, ethnicity, gender, children - could be of benefit for global healthcare policy and practice. PMID:21895893

  3. Inclusion bodies: formation and degeneration of the oocytes in the fish Channa punctatus (Bloch) in response to ammonium sulfate treatment

    SciTech Connect

    Ram, R.N.; Sathyanesan, A.G.

    1986-06-01

    In the adult Channa punctatus exposed to 500 ppm of the commonly used fertilizer ammonium sulfate for 6 months from January to June, ovarian growth was retarded significantly. The inhibition of the ovarian growth is reflected on the gonadosomatic index which was significantly reduced as compared with control. Apart from this, in treated fish, several stage-I oocytes exhibited proteinaceous extra- and intranuclear inclusion bodies which are apparently due to cumulative toxic effect of ammonium sulfate. These oocytes ultimately degenerate.

  4. Inclusive teaching.

    PubMed

    Billings, Diane M

    2008-07-01

    Inclusive teaching involves being responsive to the diversity represented in the classroom and assisting learners to focus on their culture, attitudes, and beliefs while learning to communicate and collaborate with each other and their patients. PMID:18649804

  5. Intranuclear verrucomicrobial symbionts and evidence of lateral gene transfer to the host protist in the termite gut.

    PubMed

    Sato, Tomoyuki; Kuwahara, Hirokazu; Fujita, Kazuma; Noda, Satoko; Kihara, Kumiko; Yamada, Akinori; Ohkuma, Moriya; Hongoh, Yuichi

    2014-05-01

    In 1944, Harold Kirby described microorganisms living within nuclei of the protists Trichonympha in guts of termites; however, their taxonomic assignment remains to be accomplished. Here, we identified intranuclear symbionts of Trichonympha agilis in the gut of the termite Reticulitermes speratus. We isolated single nuclei of T. agilis, performed whole-genome amplification, and obtained bacterial 16S rRNA genes by PCR. Unexpectedly, however, all of the analyzed clones were from pseudogenes of 16S rRNA with large deletions and numerous sequence variations even within a single-nucleus sample. Authentic 16S rRNA gene sequences were finally recovered by digesting the nuclear DNA; these pseudogenes were present on the host Trichonympha genome. The authentic sequences represented two distinct bacterial species belonging to the phylum Verrucomicrobia, and the pseudogenes have originated from each of the two species. Fluorescence in situ hybridization confirmed that both species are specifically localized, and occasionally co-localized, within nuclei of T. agilis. Transmission electron microscopy revealed that they are distorted cocci with characteristic electron-dense and lucent regions, which resemble the intranuclear symbionts illustrated by Kirby. For these symbionts, we propose a novel genus and species, 'Candidatus Nucleococcus trichonymphae' and 'Candidatus Nucleococcus kirbyi'. These formed a termite-specific cluster with database sequences, other members of which were also detected within nuclei of various gut protists, including both parabasalids and oxymonads. We suggest that this group is widely distributed as intranuclear symbionts of diverse protists in termite guts and that they might have affected the evolution of the host genome through lateral gene transfer. PMID:24335826

  6. Intranuclear verrucomicrobial symbionts and evidence of lateral gene transfer to the host protist in the termite gut

    PubMed Central

    Sato, Tomoyuki; Kuwahara, Hirokazu; Fujita, Kazuma; Noda, Satoko; Kihara, Kumiko; Yamada, Akinori; Ohkuma, Moriya; Hongoh, Yuichi

    2014-01-01

    In 1944, Harold Kirby described microorganisms living within nuclei of the protists Trichonympha in guts of termites; however, their taxonomic assignment remains to be accomplished. Here, we identified intranuclear symbionts of Trichonympha agilis in the gut of the termite Reticulitermes speratus. We isolated single nuclei of T. agilis, performed whole-genome amplification, and obtained bacterial 16S rRNA genes by PCR. Unexpectedly, however, all of the analyzed clones were from pseudogenes of 16S rRNA with large deletions and numerous sequence variations even within a single-nucleus sample. Authentic 16S rRNA gene sequences were finally recovered by digesting the nuclear DNA; these pseudogenes were present on the host Trichonympha genome. The authentic sequences represented two distinct bacterial species belonging to the phylum Verrucomicrobia, and the pseudogenes have originated from each of the two species. Fluorescence in situ hybridization confirmed that both species are specifically localized, and occasionally co-localized, within nuclei of T. agilis. Transmission electron microscopy revealed that they are distorted cocci with characteristic electron-dense and lucent regions, which resemble the intranuclear symbionts illustrated by Kirby. For these symbionts, we propose a novel genus and species, ‘Candidatus Nucleococcus trichonymphae' and ‘Candidatus Nucleococcus kirbyi'. These formed a termite-specific cluster with database sequences, other members of which were also detected within nuclei of various gut protists, including both parabasalids and oxymonads. We suggest that this group is widely distributed as intranuclear symbionts of diverse protists in termite guts and that they might have affected the evolution of the host genome through lateral gene transfer. PMID:24335826

  7. Preschool Inclusion.

    ERIC Educational Resources Information Center

    Cavallaro, Claire C.; Haney, Michele

    This resource guide provides field-tested, research-based strategies for including young children with disabilities in early childhood programs. It is designed to help preservice and in-service educators, Head Start personnel, and child care providers with information to promote inclusion in children's earliest social and educational experiences.…

  8. Use and cost-effectiveness of intraoperative acid-fast bacilli and fungal cultures in assessing infection of joint arthroplasties.

    PubMed

    Wadey, Veronica M; Huddleston, James I; Goodman, Stuart B; Schurman, David J; Maloney, William J; Baron, Ellen J

    2010-12-01

    The objective of this study is to determine a protocol for collecting acid-fast bacilli (AFB) and fungal intraoperative cultures during orthopedic procedures. An observational study was undertaken. Four hundred forty-six AFB cultures and 486 fungal cultures were processed over a 2-year period. The number of positive cultures was determined. A protocol specific to handling these types of specimens was developed. Cost analysis was completed to determine both the time and money saved if the new protocol was implemented. The infrequency of positive AFB and fungal cultures in this study suggests that it is only necessary to routinely request AFB and fungal cultures on 1 of 5 samples. Implementation of this protocol has potential to lead to substantial cost reduction and resource savings without diminishing patient outcomes. PMID:19879728

  9. Draft Genome Sequences of Two Novel Amoeba-Resistant Intranuclear Bacteria, “Candidatus Berkiella cookevillensis” and “Candidatus Berkiella aquae”

    PubMed Central

    Mehari, Yohannes T.; Arivett, Brock A.; Farone, Anthony L.; Gunderson, John H.

    2016-01-01

    “Candidatus Berkiella cookevillensis” and “Candidatus Berkiella aquae” are obligate intranuclear endosymbionts of freshwater amoebae. Here, we present the draft genome sequences of these two bacteria, with total sizes of 2,990,361 bp and 3,626,027 bp, respectively. PMID:26893424

  10. Cross sections of proton- and neutron-induced reactions by the Liège intranuclear cascade model

    NASA Astrophysics Data System (ADS)

    Chen, Jian; Dong, Tiekuang; Ren, Zhongzhou

    2016-06-01

    The purpose of the paper is mainly to test the validity of the Liège intranuclear cascade (INCL) model in calculating the cross sections of proton-induced reactions for cosmogenic nuclei using the newly compiled database of proton cross sections. The model calculations of 3He display the rising tendency of cross sections with the increase of energy, in accordance with the experimental data. Meanwhile, the differences between the theoretical results and experimental data of production cross sections (10Be and 26Al) are generally within a factor of 3, meaning that the INCL model works quite well for the proton-induced reactions. Based on the good agreement, we predict the production cross sections of 26Al from reactions n + 27Al, n + 28Si, and n + 40Ca and those of 10Be from reactions n + 16O and n + 28Si. The results also show a good agreement with a posteriori excitation functions.

  11. Orchid Fleck Virus Structural Proteins N and P Form Intranuclear Viroplasm-Like Structures in the Absence of Viral Infection

    PubMed Central

    Chiba, Sotaro; Andika, Ida Bagus; Maruyama, Kazuyuki; Tamada, Tetsuo; Suzuki, Nobuhiro

    2013-01-01

    Orchid fleck virus (OFV) has a unique two-segmented negative-sense RNA genome that resembles that of plant nucleorhabdoviruses. In infected plant cells, OFV and nucleorhabdoviruses induce an intranuclear electron-lucent viroplasm that is believed to be the site for virus replication. In this study, we investigated the molecular mechanism by which OFV viroplasms are produced in vivo. Among OFV-encoded proteins, the nucleocapsid protein (N) and the putative phosphoprotein (P) were present in nuclear fractions of OFV-infected Nicotiana benthamiana plants. Transient coexpression of N and P, in the absence of virus infection, was shown to be sufficient for formation of an intranuclear viroplasm-like structure in plant cells. When expressed independently as a fluorescent protein fusion product in uninfected plant cells, N protein accumulated throughout the cell, while P protein accumulated in the nucleus. However, the N protein, when coexpressed with P, was recruited to a subnuclear region to induce a large viroplasm-like focus. Deletion and substitution mutagenesis demonstrated that the P protein contains a nuclear localization signal (NLS). Artificial nuclear targeting of the N-protein mutant was insufficient for formation of viroplasm-like structures in the absence of P. A bimolecular fluorescence complementation assay confirmed interactions between the N and P proteins within subnuclear viroplasm-like foci and interactions of two of the N. benthamiana importin-α homologues with the P protein but not with the N protein. Taken together, our results suggest that viroplasm formation by OFV requires nuclear accumulation of both the N and P proteins, which is mediated by P-NLS, unlike nucleorhabdovirus viroplasm utilizing the NLS on protein N. PMID:23616651

  12. Intranuclear Delivery of a Novel Antibody-Derived Radiosensitizer Targeting the DNA-Dependent Protein Kinase Catalytic Subunit

    SciTech Connect

    Xiong Hairong; Lee, Robert J.; Haura, Eric B.; Edwards, John G.; Dynan, William S.; Li Shuyi

    2012-07-01

    Purpose: To inhibit DNA double-strand break repair in tumor cells by delivery of a single-chain antibody variable region fragment (ScFv 18-2) to the cell nucleus. ScFv 18-2 binds to a regulatory region of the DNA-dependent protein kinase (DNA-PK), an essential enzyme in the nonhomologous end-joining pathway, and inhibits DNA end-joining in a cell-free system and when microinjected into single cells. Development as a radiosensitizer has been limited by the lack of a method for intranuclear delivery to target cells. We investigated a delivery method based on folate receptor-mediated endocytosis. Methods and Materials: A recombinant ScFv 18-2 derivative was conjugated to folate via a scissile disulfide linker. Folate-ScFv 18-2 was characterized for its ability to be internalized by tumor cells and to influence the behavior of ionizing radiation-induced repair foci. Radiosensitization was measured in a clonogenic survival assay. Survival curves were fitted to a linear-quadratic model, and between-group differences were evaluated by an F test. Sensitization ratios were determined based on mean inhibitory dose. Results: Human KB and NCI-H292 lung cancer cells treated with folate-conjugated ScFv 18-2 showed significant radiosensitization (p < 0.001). Sensitization enhancement ratios were 1.92 {+-} 0.42 for KB cells and 1.63 {+-} 0.13 for NCI-H292 cells. Studies suggest that treatment inhibits repair of radiation-induced DSBs, as evidenced by the persistence of {gamma}-H2AX-stained foci and by inhibition of staining with anti-DNA-PKcs phosphoserine 2056. Conclusions: Folate-mediated endocytosis is an effective method for intranuclear delivery of an antibody-derived DNA repair inhibitor.

  13. Nuclear translocation and regulation of intranuclear distribution of cytoplasmic poly(A)-binding protein are distinct processes mediated by two Epstein Barr virus proteins.

    PubMed

    Park, Richard; El-Guindy, Ayman; Heston, Lee; Lin, Su-Fang; Yu, Kuan-Ping; Nagy, Mate; Borah, Sumit; Delecluse, Henri-Jacques; Steitz, Joan; Miller, George

    2014-01-01

    Many viruses target cytoplasmic polyA binding protein (PABPC) to effect widespread inhibition of host gene expression, a process termed viral host-shutoff (vhs). During lytic replication of Epstein Barr Virus (EBV) we observed that PABPC was efficiently translocated from the cytoplasm to the nucleus. Translocated PABPC was diffusely distributed but was excluded from viral replication compartments. Vhs during EBV infection is regulated by the viral alkaline nuclease, BGLF5. Transfection of BGLF5 alone into BGLF5-KO cells or uninfected 293 cells promoted translocation of PAPBC that was distributed in clumps in the nucleus. ZEBRA, a viral bZIP protein, performs essential functions in the lytic program of EBV, including activation or repression of downstream viral genes. ZEBRA is also an essential replication protein that binds to viral oriLyt and interacts with other viral replication proteins. We report that ZEBRA also functions as a regulator of vhs. ZEBRA translocated PABPC to the nucleus, controlled the intranuclear distribution of PABPC, and caused global shutoff of host gene expression. Transfection of ZEBRA alone into 293 cells caused nuclear translocation of PABPC in the majority of cells in which ZEBRA was expressed. Co-transfection of ZEBRA with BGLF5 into BGLF5-KO cells or uninfected 293 cells rescued the diffuse intranuclear pattern of PABPC seen during lytic replication. ZEBRA mutants defective for DNA-binding were capable of regulating the intranuclear distribution of PABPC, and caused PABPC to co-localize with ZEBRA. One ZEBRA mutant, Z(S186E), was deficient in translocation yet was capable of altering the intranuclear distribution of PABPC. Therefore ZEBRA-mediated nuclear translocation of PABPC and regulation of intranuclear PABPC distribution are distinct events. Using a click chemistry-based assay for new protein synthesis, we show that ZEBRA and BGLF5 each function as viral host shutoff factors. PMID:24705134

  14. Anisotropic tubular filtering for automatic detection of acid-fast bacilli in Ziehl-Neelsen stained sputum smear samples

    NASA Astrophysics Data System (ADS)

    Raza, Shan-e.-Ahmed; Marjan, M. Q.; Arif, Muhammad; Butt, Farhana; Sultan, Faisal; Rajpoot, Nasir M.

    2015-03-01

    One of the main factors for high workload in pulmonary pathology in developing countries is the relatively large proportion of tuberculosis (TB) cases which can be detected with high throughput using automated approaches. TB is caused by Mycobacterium tuberculosis, which appears as thin, rod-shaped acid-fast bacillus (AFB) in Ziehl-Neelsen (ZN) stained sputum smear samples. In this paper, we present an algorithm for automatic detection of AFB in digitized images of ZN stained sputum smear samples under a light microscope. A key component of the proposed algorithm is the enhancement of raw input image using a novel anisotropic tubular filter (ATF) which suppresses the background noise while simultaneously enhancing strong anisotropic features of AFBs present in the image. The resulting image is then segmented using color features and candidate AFBs are identified. Finally, a support vector machine classifier using morphological features from candidate AFBs decides whether a given image is AFB positive or not. We demonstrate the effectiveness of the proposed ATF method with two different feature sets by showing that the proposed image analysis pipeline results in higher accuracy and F1-score than the same pipeline with standard median filtering for image enhancement.

  15. Neuro-Sweet disease with positive modified acid-fast staining of the cerebrospinal fluid: A case report

    PubMed Central

    LIU, JUAN-FANG; LI, YUAN; LI, KAI; ZHANG, XIAO; YANG, YI-NING; ZHAO, GANG; LIU, ZHI-RONG

    2016-01-01

    Neuro-Sweet disease (NSD) is Sweet disease with central nervous system (CNS) involvement. To the best of our knowledge, the present case report is the first to describe NSD complicated by endogenous infection with Mycobacterium tuberculosis. The present case report describes a male patient who developed NSD-induced meningitis, which initially manifested as a fever, headache and neck stiffness. Painful erythematous plaques subsequently developed on his face, neck and upper trunk. Brain magnetic resonance imaging was performed and the results were normal, whereas modified acid-fast stain analysis of the cerebrospinal fluid (CSF) provided a positive result. The patient was thus diagnosed with viral meningitis and tuberculosis. However, subsequent skin biopsy results demonstrated neutrophilic infiltration into the dermis without vasculitis, and subsequent human leukocyte antigen typing was positive for Cw1 and negative for B51 and the patient was diagnosed with NSD. Following treatment with corticosteroids, and antiviral and anti-tuberculotic agents, the clinical symptoms were reduced and the previously abnormal findings in the CSF examinations and associated laboratory data were improved. The present case indicates that the diagnosis of NSD is not easily achieved, and early skin biopsy is vital to ensure a fast and effective diagnosis. In addition to systemic corticosteroids, comprehensive treatment is also recommended for patients with NSD complicated by additional complex medical problems. PMID:27073429

  16. Fine structural analysis of the neuronal inclusions of frontotemporal lobar degeneration with TDP-43 proteinopathy

    PubMed Central

    Tang, Helen; Atherton, Joe; Cairns, Nigel J.

    2009-01-01

    TAR DNA-binding protein of 43 kDa (TDP-43) is a major component of the pathological inclusions of frontotemporal lobar degeneration with TDP-43 proteinopathy, also called FTLD with ubiquitin-positive, tau-negative inclusions (FTLD-U), and motor neuron disease (MND). TDP-43 is predominantly expressed in the nucleus and regulates gene expression and splicing. In FTLD with TDP-43 proteinopathy, neuronal inclusions present variably as cytoplasmic inclusions (NCIs), dystrophic neurites (DNs), and intranuclear inclusions (NIIs), leading to a fourfold neuropathological classification correlating with genotype. There have been few fine structural studies of these inclusions. Thus, we undertook an immunoelectron microscopic study of FTLD with TDP-43 proteinopathy, including sporadic and familial cases with progranulin (GRN) mutation. TDP-43-immunoreactive inclusions comprised two components: granular and filamentous. Filament widths, expressed as mean (range) were: NCI, 9 nm (4–16 nm); DN, 10 nm (5–16 nm); NII, 18 nm (9–50 nm). Morphologically distinct inclusion components may reflect the process of TDP-43 aggregation and interaction with other proteins: determining these latter may contribute towards understanding the heterogeneous pathogenesis of FTLD with TDP-43 proteinopathy. PMID:18974920

  17. Fine structural analysis of the neuronal inclusions of frontotemporal lobar degeneration with TDP-43 proteinopathy.

    PubMed

    Thorpe, Julian R; Tang, Helen; Atherton, Joe; Cairns, Nigel J

    2008-12-01

    TAR DNA-binding protein of 43 kDa (TDP-43) is a major component of the pathological inclusions of frontotemporal lobar degeneration with TDP-43 proteinopathy, also called FTLD with ubiquitin-positive, tau-negative inclusions (FTLD-U), and motor neuron disease (MND). TDP-43 is predominantly expressed in the nucleus and regulates gene expression and splicing. In FTLD with TDP-43 proteinopathy, neuronal inclusions present variably as cytoplasmic inclusions (NCIs), dystrophic neurites (DNs), and intranuclear inclusions (NIIs), leading to a fourfold neuropathological classification correlating with genotype. There have been few fine structural studies of these inclusions. Thus, we undertook an immunoelectron microscopic study of FTLD with TDP-43 proteinopathy, including sporadic and familial cases with progranulin (GRN) mutation. TDP-43-immunoreactive inclusions comprised two components: granular and filamentous. Filament widths, expressed as mean (range) were: NCI, 9 nm (4-16 nm); DN, 10 nm (5-16 nm); NII, 18 nm (9-50 nm). Morphologically distinct inclusion components may reflect the process of TDP-43 aggregation and interaction with other proteins: determining these latter may contribute towards understanding the heterogeneous pathogenesis of FTLD with TDP-43 proteinopathy. PMID:18974920

  18. Characterization of ubiquitinated intraneuronal inclusions in a novel Belgian frontotemporal lobar degeneration family.

    PubMed

    Pirici, Daniel; Vandenberghe, Rik; Rademakers, Rosa; Dermaut, Bart; Cruts, Marc; Vennekens, Krist'l; Cuijt, Ivy; Lübke, Ursula; Ceuterick, Chantal; Martin, Jean-Jacques; Van Broeckhoven, Christine; Kumar-Singh, Samir

    2006-03-01

    The most common histologic feature in patients with frontotemporal lobar degeneration (FTLD) is intracellular brain inclusions of yet uncharacterized proteins that react with antiubiquitin (Ub) antibodies, but not with tau or synuclein (FTLD-U). We identified a four-generation Belgian FTLD family in which 8 patients had dominantly inherited FTLD. In one patient, we showed frontotemporal atrophy with filamentous Ub-positive intracellular inclusions in absence of tau pathology or any alterations in the levels of soluble tau. We characterized the cellular and subcellular localization and morphology of the inclusions. Ub-positive inclusions predominantly occurred within neurons (>97%), but were also observed within oligodendroglia (approximately 2%) and microglia (<1%), but not within astroglia. Regarding the subcellular localization, the intranuclear inclusions (INI) were up to approximately four-fold more frequent than the cytoplasmic inclusions, although the latter were more specific to neurons. The INIs frequently appeared spindle-shaped and 3-dimensional confocal reconstructions identified flattened, leaf-like structures. Ultrastructurally, straight 10- to 18-nm-diameter filaments constituted the spindle-shaped inclusions that occurred in close proximity to the nuclear membrane. Staining for HSP40, p62, and valosin/p97 was observed in only a minority of the inclusions. Whereas the precise nature of the protein remains elusive, characterization of such familial FTLD-U patients would be helpful in identifying a common denominator in the pathogenesis of familial and the more prevalent sporadic FTLD-U. PMID:16651890

  19. Improving sensitivity of direct microscopy for detection of acid-fast bacilli in sputum: use of chitin in mucus digestion.

    PubMed

    Farnia, P; Mohammadi, F; Zarifi, Z; Tabatabee, D J; Ganavi, J; Ghazisaeedi, K; Farnia, P K; Gheydi, M; Bahadori, M; Masjedi, M R; Velayati, A A

    2002-02-01

    In order to try to improve the results of direct smear microscopy, we used the mucus-digesting quality of chitin in tuberculosis (TB) laboratories. For this purpose, a total of 430 sputum specimens were processed by the N-acetyl-L-cysteine concentration, sodium hypochlorite (NaOCl) liquefaction, chitin sedimentation, and direct microscopy methods. Then, the smear sensitivity for acid-fast bacillus detection by chitin-treated sputum was compared with the sensitivity of smears prepared by other methods. Our results showed that the chitin solution took less time to completely homogenize the mucoid sputum than did the N-acetyl-L-cysteine and NaOCl methods. The N-acetyl-L-cysteine concentration method demonstrated sensitivity and specificity levels of 83 and 97%, respectively. In comparison, the sensitivity of chitin sedimentation was 80%, with a specificity of 96.7%. The NaOCl liquefaction method showed a sensitivity of 78%, with a specificity of 96%. Finally, the sensitivity of direct microscopy was lower than those of the other tested methods and was only 46%, with a specificity of 90%. The chitin and NaOCl liquefaction methods are both easy to perform, and they do not require additional equipment (centrifuges). Also, our results demonstrated that the chitin method is less time-consuming than the NaOCl method, since only 30 min of incubation is required to bring complete sedimentation of bacilli in chitin-treated sputum whereas the NaOCl method needs 10 to 12 h to give the same results in the same sputum specimens. Therefore, the chitin liquefaction and sedimentation method may provide better results in TB laboratories of developing countries than the N-acetyl-L-cysteine concentration, NaOCl overnight sedimentation, and direct smear microscopy methods. PMID:11825964

  20. Decentralization of Acid Fast Bacilli(AFB) External Quality Assurance Using Blind Rechecking for Sputum Smear Microscopy in Ethiopia

    PubMed Central

    Melese, Muluken; Jerene, Degu; Alem, Genetu; Seid, Jemal; Belachew, Feleke; Kassie, Yewulsew; Habte, Dereje; Negash, Solomon; Ayana, Gonfa; Girma, Belaineh; Haile, Yared K.; Hiruy, Nebiyu; Suarez, Pedro G.

    2016-01-01

    Introduction Ethiopia achieved a rapid expansion of TB microscopic centers for acid fast bacilli (AFB). However, external quality assurance (EQA) services were, until recently, limited to few regional and sub-regional laboratories. In this paper, we describe the decentralization experience and the result of EQA using random blinded rechecking. Materials and Methods The routine EQA quarterly report was compiled and analyzed. A positive result by the microscopic center while the EQA center reported negative result is categorized as false positive (FP). A negative result by the microscopic center while the EQA center reported positive is considered false negative (FN). The reading of EQA centers was considered a gold standard to compute the sensitivity, specificity, positive predictive (PPV) and negative predictive values (NPV) of the readings of microscopic centers. Results We decentralized sputum smear AFB EQA from 4 Regional Laboratories (RRLs) to 82 EQA centers and enrolled 956 health facilities in EQA schemes. Enrollment of HFs in EQA was gradual because it required training and mentoring laboratory professionals, institutionalizing internal QA measures, equipping all HFs to perform diagnosis, and establishing more EQA centers. From 2012 to 2014 (Phase I), the FP rate declined from 0.6% to 0.2% and FN fell from as high as 7.6% to 1.6% in supported health facilities (HFs). In HFs that joined in Phase II, FN rates ranged from 5.6 to 7.3%. The proportion of HFs without errors has increased from 77.9% to 90.5% in Phase I HFs and from 82.9% to 86.9% in Phase II HFs. Overall sensitivity and specificity were 95.0% and 99.7%, respectively. PPV and NPV were 93.3% and 99.7%, respectively. Conclusion Decentralizing blinded rechecking of sputum smear microscopy is feasible in low-income settings. While a comprehensive laboratory improvement strategy enhanced the quality of microscopy, laboratory professionals’ capacity in slide reading and smear quality requires continued

  1. Design of a microfluidic device to quantify dynamic intra-nuclear deformation during cell migration through confining environments

    PubMed Central

    Davidson, Patricia M.; Sliz, Josiah; Isermann, Philipp; Denais, Celine; Lammerding, Jan

    2015-01-01

    The ability of cells to migrate through tissues and interstitial space is an essential factor during development and tissue homeostasis, immune cell mobility, and in various human diseases. Deformation of the nucleus and its associated lamina during 3-D migration is gathering increasing interest in the context of cancer metastasis, with the underlying hypothesis that a softer nucleus, resulting from reduced levels of lamin A/C, may aid tumour spreading. However, current methods to study the migration of cells in confining three dimensional (3-D) environments are limited by their imprecise control over the confinement, physiological relevance, and/or compatibility with high resolution imaging techniques. We describe the design of a polydimethylsiloxane (PDMS) microfluidic device composed of channels with precisely-defined constrictions mimicking physiological environments that enable high resolution imaging of live and fixed cells. The device promotes easy cell loading and rapid, yet long-lasting (>24 hours) chemotactic gradient formation without the need for continuous perfusion. Using this device, we obtained detailed, quantitative measurements of dynamic nuclear deformation as cells migrate through tight spaces, revealing distinct phases of nuclear translocation through the constriction, buckling of the nuclear lamina, and severe intranuclear strain. Furthermore, we found that lamin A/C-deficient cells exhibited increased and more plastic nuclear deformations compared to wild-type cells but only minimal changes in nuclear volume, implying that low lamin A/C levels facilitate migration through constrictions by increasing nuclear deformability rather than compressibility. The integration of our migration devices with high resolution time-lapse imaging provides a powerful new approach to study intracellular mechanics and dynamics in a variety of physiologically-relevant applications, ranging from cancer cell invasion to immune cell recruitment. PMID:26549481

  2. Nuclear inclusions mimicking poly(A)-binding protein nuclear 1 inclusions in a case of inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia with a novel mutation in the valosin-containing protein gene.

    PubMed

    Matsubara, Shiro; Shimizu, Toshio; Komori, Takashi; Mori-Yoshimura, Madoka; Minami, Narihiro; Hayashi, Yukiko K

    2016-07-01

    A middle-aged Japanese man presented with slowly progressive asymmetric weakness of legs and arm but had neither ptosis nor dysphagia. He had a family history of similar condition suggestive of autosomal dominant inheritance. A muscle biopsy showed mixture of neurogenic atrophy and myopathy with rimmed vacuoles. Furthermore we found intranuclear inclusions that had a fine structure mimicking that of inclusions reported in oculopharyngeal muscular dystrophy (OPMD). Immunohistochemical staining for polyadenylate-binding nuclear protein 1, which is identified within the nuclear inclusions of OPMD, demonstrated nuclear positivity in this case. However, OPMD was thought unlikely based on the clinical features and results of genetic analyses. Instead, a novel mutation in valosin-containing protein, c.376A>T (p.Ile126Phe), was revealed. A diagnosis of inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia was made. This is the first report of polyadenylate-binding nuclear protein 1-positive nuclear inclusions in the muscle of this condition. PMID:27209344

  3. Limits to Inclusion

    ERIC Educational Resources Information Center

    Hansen, Janne Hedegaard

    2012-01-01

    In this article, I will argue that a theoretical identification of the limit to inclusion is needed in the conceptual identification of inclusion. On the one hand, inclusion is formulated as a vision that is, in principle, limitless. On the other hand, there seems to be an agreement that inclusion has a limit in the pedagogical practice. However,…

  4. ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress.

    PubMed

    McLean, Jesse R; Smith, Gaynor A; Rocha, Emily M; Osborn, Teresia M; Dib, Samar; Hayes, Melissa A; Beagan, Jonathan A; Brown, Tana B; Lawson, Tristan F S; Hallett, Penelope J; Robertson, Janice; Isacson, Ole

    2014-11-01

    Intracellular proteinaceous inclusions are well-documented hallmarks of the fatal motor neuron disorder amyotrophic lateral sclerosis (ALS). The pathological significance of these inclusions remains unknown. Peripherin, a type III intermediate filament protein, is upregulated in ALS and identified as a component within different types of ALS inclusions. The formation of these inclusions may be associated with abnormal peripherin splicing, whereby an increase in mRNA retaining introns 3 and 4 (Per-3,4) leads to the generation of an aggregation-prone isoform, Per-28. During the course of evaluating peripherin filament assembly in SW-13 cells, we identified that expression of both Per-3,4 and Per-28 transcripts formed inclusions with categorically distinct morphology: Per-3,4 was associated with cytoplasmic condensed/bundled filaments, small inclusions (<10μM), or large inclusions (≥10μM); while Per-28 was associated with punctate inclusions in the nucleus and/or cytoplasm. We found temporal and spatial changes in inclusion morphology between 12 and 48h post-transfected cells, which were accompanied by unique immunofluorescent and biochemical changes of other ALS-relevant proteins, including TDP-43 and ubiquitin. Despite mild cytotoxicity associated with peripherin transfection, Per-3,4 and Per-28 expression increased cell viability during H2O2-mediated oxidative stress in BE(2)-M17 neuroblastoma cells. Taken together, this study shows that ALS-associated peripherin isoforms form dynamic cytoplasmic and intranuclear inclusions, effect changes in local endogenous protein expression, and afford cytoprotection against oxidative stress. These findings may have important relevance to understanding the pathophysiological role of inclusions in ALS. PMID:24907400

  5. Inclusion body disease of cranes: comparison of pathologic findings in cranes with acquired vs. experimentally induced disease

    USGS Publications Warehouse

    Schuh, J.C.; Sileo, L.; Siegfried, L.M.; Yuill, Thomas M.

    1986-01-01

    Inclusion body disease of cranes was the cause of death in 17 immature and mature cranes of 5 different species in Wisconsin. A herpesvirus of unknown origin was the apparent cause. An isolate of this herpesvirus was used to experimentally infect 3 species of cranes. Macroscopic and microscopic lesions associated with naturally acquired and experimentally induced disease were essentially identical. Multifocal hepatic and splenic necrosis was found in all cranes evaluated. Necrosis of the gastrointestinal tract, thymus, and bursa of Fabricius also was seen in some of the cranes. Eosinophilic intranuclear inclusion bodies often were commonly associated with hepatic lesions, sometimes with the splenic lesions, and rarely with the thymic or gastrointestinal tract lesions. The lesions of this inclusion body disease were similar to those reported for cranes in Austria from which a crane herpesvirus was isolated.

  6. Comparison of an acid-fast stain and a monoclonal antibody-based immunofluorescence reagent for the detection of Cryptosporidium oocysts in faecal specimens from cattle and pigs.

    PubMed

    Quílez, J; Sánchez-Acedo, C; Clavel, A; del Cacho, E; López-Bernad, F

    1996-12-01

    A commercially available direct immunofluorescence (IF) assay with monoclonal antibodies (Monofluo Kit Cryptosporidium, Diagnostics Pasteur, France) was compared with the modified Ziehl-Neelsen (MZN) acid-fast technique for the detection of Cryptosporidium oocysts in faecal samples from cattle and pigs. Stool specimens individually collected from 108 bovines and 90 pigs were examined in a blind test. The results of the two procedures corresponded (both positive or negative) in 102 (94.4%) cattle samples and 80 (88.9%) pig faecal samples. However, the remaining six (5.5%) cattle specimens and 10 (11.1%) pig stool samples, all of them harboring few oocysts (0-1 oocysts per 20 x field), were negative by MZN and positive by IF. False-negative results of the acid-fast stain occurred in suckling (17.2% of discrepant results) and weaned calves (2.9%) as well as weaned piglets (43.7%) and fattening pigs (10%). Stool specimens from the remaining age groups were negative by both techniques. The MacNemar's chi-square test showed that differences between both methods were statistically significant (P < 0.05). Compared with immunofluorescence procedure, the sensitivity of MZN technique in samples from cattle and pigs was 79.3% and 67.7% and the negative predictive value was 92.9% and 85.5% respectively. The specificity and positive predictive values of the acid-fast stain were 100% in both animal species. It is concluded that the monoclonal antibody-based immunofluorescence reagent evaluated is more efficient that the MZN technique, especially for detecting a low number of Cryptosporidium oocysts, in faecal specimens from both cattle and pigs. PMID:9011016

  7. TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

    SciTech Connect

    Arai, Tetsuaki . E-mail: arai@prit.go.jp; Hasegawa, Masato . E-mail: masato@prit.go.jp; Akiyama, Haruhiko; Ikeda, Kenji; Nonaka, Takashi; Mori, Hiroshi; Mann, David; Tsuchiya, Kuniaki; Yoshida, Mari; Hashizume, Yoshio; Oda, Tatsuro

    2006-12-22

    Ubiquitin-positive tau-negative neuronal cytoplasmic inclusions and dystrophic neurites are common pathological features in frontotemporal lobar degeneration (FTLD) with or without symptoms of motor neuron disease and in amyotrophic lateral sclerosis (ALS). Using biochemical and immunohistochemical analyses, we have identified a TAR DNA-binding protein of 43 kDa (TDP-43), a nuclear factor that functions in regulating transcription and alternative splicing, as a component of these structures in FTLD. Furthermore, skein-like inclusions, neuronal intranuclear inclusions, and glial inclusions in the spinal cord of ALS patients are also positive for TDP-43. Dephosphorylation treatment of the sarkosyl insoluble fraction has shown that abnormal phosphorylation takes place in accumulated TDP-43. The common occurrence of intracellular accumulations of TDP-43 supports the hypothesis that these disorders represent a clinicopathological entity of a single disease, and suggests that they can be newly classified as a proteinopathy of TDP-43.

  8. Epidemic adenovirus inclusions body hepatitis of the chicken in Australia.

    PubMed

    Wells, R J; Westbury, H A; Harrigan, K E; Coleman, G D; Beilharz, R G

    1977-12-01

    The occurrence of inclusion body hepatitis (IBH) on 11 properties in Australia is described. The 6 Victorian cases occurred between 1967 and 1973 and were identified as incidental findings accompanying other diseases or occurred as ill-defined, minor economic disease episodes. In well-managed flocks the extra mortality attributable to IBH was as low as 1.8% which represented a 50% increase in total mortality. The 1973 epidemic in New South Wales on 5 related farms resulted in flock mortality of 8.4% to 32.3% and an average mortality of 19.5% of 814,000 birds. For uninfected flocks of 307,000 birds the average mortality was 8.5%. Higher mortality in male flocks was statistically highly significant as was lowered efficiency of feed conversion. Growth rate in both sexes was depressed by about 0.15 kg in 70 days and heavy downgrading at processing occurred. Secondary infections were important. The cardinal features of IBH were fatal necrotising hepatitis with Cowdry type-A intranuclear inclusion body formation; secondary bacterial infections were also important causes of loss. PMID:207252

  9. Fluid Inclusion Gas Analysis

    DOE Data Explorer

    Dilley, Lorie

    2013-01-01

    Fluid inclusion gas analysis for wells in various geothermal areas. Analyses used in developing fluid inclusion stratigraphy for wells and defining fluids across the geothermal fields. Each sample has mass spectrum counts for 180 chemical species.

  10. Inclusion Body Myositis

    MedlinePlus

    ... What is Inclusion Body Myositis? Inclusion body myositis (IBM) is one of a group of muscle diseases ... muscle weakness. The onset of muscle weakness in IBM is generally gradual (over months or years) and ...

  11. Induction of intranuclear membranes by overproduction of Opi1p and Scs2p, regulators for yeast phospholipid biosynthesis, suggests a mechanism for Opi1p nuclear translocation.

    PubMed

    Masuda, Miki; Oshima, Ayaka; Noguchi, Tetsuko; Kagiwada, Satoshi

    2016-03-01

    In the yeast Saccharomyces cerevisiae, the expression of phospholipid biosynthetic genes is suppressed by the Opi1p negative regulator. Opi1p enters into the nucleoplasm from the nuclear membrane to suppress the gene expression under repressing conditions. The binding of Opi1p to the nuclear membrane requires an integral membrane protein, Scs2p and phosphatidic acid (PA). Although it is demonstrated that the association of Opi1p with membranes is affected by PA levels, how Opi1p dissociates from Scs2p is unknown. Here, we found that fluorescently labelled Opi1p accumulated on a perinuclear region in an Scs2p-dependent manner. Electron microscopic analyses indicated that the perinuclear region consists of intranuclear membranes, which may be formed by the invagination of the nuclear membrane due to the accumulation of Opi1p and Scs2p in a restricted area. As expected, localization of Opi1p and Scs2p in the intranuclear membranes was detected by immunoelectron microscopy. Biochemical analysis showed that Opi1p recovered in the membrane fraction was detergent insoluble while Scs2p was soluble, implying that Opi1p behaves differently from Scs2p in the fraction. We hypothesize that Opi1p dissociates from Scs2p after targeting to the nuclear membrane, making it possible to be released from the membrane quickly when PA levels decrease. PMID:26590299

  12. Hyperinvasive Meningococci Induce Intra-nuclear Cleavage of the NF-κB Protein p65/RelA by Meningococcal IgA Protease

    PubMed Central

    Besbes, Anissa; Le Goff, Salomé; Antunes, Ana; Terrade, Aude; Hong, Eva; Giorgini, Dario; Taha, Muhamed-Kheir; Deghmane, Ala-Eddine

    2015-01-01

    Differential modulation of NF-κB during meningococcal infection is critical in innate immune response to meningococcal disease. Non-invasive isolates of Neisseria meningitidis provoke a sustained NF-κB activation in epithelial cells. However, the hyperinvasive isolates of the ST-11 clonal complex (ST-11) only induce an early NF-κB activation followed by a sustained activation of JNK and apoptosis. We show that this temporal activation of NF-κB was caused by specific cleavage at the C-terminal region of NF-κB p65/RelA component within the nucleus of infected cells. This cleavage was mediated by the secreted 150 kDa meningococcal ST-11 IgA protease carrying nuclear localisation signals (NLS) in its α-peptide moiety that allowed efficient intra-nuclear transport. In a collection of non-ST-11 healthy carriage isolates lacking NLS in the α-peptide, secreted IgA protease was devoid of intra-nuclear transport. This part of iga polymorphism allows non-invasive isolates lacking NLS, unlike hyperinvasive ST-11 isolates of N. meningitides habouring NLS in their α-peptide, to be carried asymptomatically in the human nasopharynx through selective eradication of their ability to induce apoptosis in infected epithelial cells. PMID:26241037

  13. Inclusive Education in Bangladesh

    ERIC Educational Resources Information Center

    Ahsan, Mohammad Tariq; Burnip, Lindsay

    2007-01-01

    This article reports on inclusive education in Bangladesh for children with special needs. Bangladesh is not behind other developed countries in enacting laws and declarations in favour of inclusive education, but a lack of resources is the main barrier in implementing inclusive education. Special education and integrated education models exist in…

  14. Inclusion in Middle Tennessee

    ERIC Educational Resources Information Center

    Hayes, Brandalyn; Ashley, Mandi; Salter, Derrick

    2013-01-01

    The overall purpose of this study was to provide school districts within Tennessee with more research about how weekly hours of inclusion impact student achievement. Specifically, researchers examined which models of inclusion were in use in two school districts in Tennessee, administrators' and teachers' perceptions of inclusion, and whether or…

  15. Towards Inclusive Schooling

    ERIC Educational Resources Information Center

    Gafoor, K. Abdul

    2010-01-01

    Social inclusion is the process that will enable every person in society to participate in normal activities of societies they live in, including education, employment, public services and social recreational activities. For the development of an inclusive society, preparation of younger generation also needs to be inclusive. Our schools must…

  16. Supporting Inclusive Practice

    ERIC Educational Resources Information Center

    Knowles, Gianna

    2006-01-01

    Written to support all teaching and learning staff in developing good inclusive practice, this book provides knowledge and understanding about a range of inclusion issues, such as what an inclusive school might look like and practical guidance on supporting the development of such a school. It also explores issues surrounding: (1) Ethnicity; (2)…

  17. Footstep towards Inclusive Education

    ERIC Educational Resources Information Center

    Abbas, Faiza; Zafar, Aneeka; Naz, Tayyaba

    2016-01-01

    Inclusive education is a rising trend in the world. The first step towards inclusive education is providing the awareness to the general education teachers. This study focused to investigate the general education teachers of primary and secondary level awareness about the special education and inclusive education. This study is descriptive method…

  18. Accumulation of Hsc70 and Hsp70 in glial cytoplasmic inclusions in patients with multiple system atrophy.

    PubMed

    Kawamoto, Yasuhiro; Akiguchi, Ichiro; Shirakashi, Yoshitomo; Honjo, Yasuyuki; Tomimoto, Hidekazu; Takahashi, Ryosuke; Budka, Herbert

    2007-03-01

    Heat shock proteins (HSPs) are molecular chaperones which can be induced by several kinds of stresses, and Hsc70 and Hsp70 are two major members of the family of 70 kDa HSPs. A major component of Lewy bodies (LBs) is alpha-synuclein, and Hsp70 has been observed in the LBs of brains with Parkinson's disease. Hsp70 has also been demonstrated to have the ability to suppress alpha-synuclein toxicity in vitro and in vivo. To investigate the precise role of Hsc70 and Hsp70 in patients with multiple system atrophy (MSA), which is another alpha-synuclein-related disease, we performed immunohistochemical studies on Hsc70 and Hsp70 using autopsied brains from 7 normal subjects and 15 patients with MSA. In the normal human brains, both neurons and glial cells, including oligodendrocytes, showed only weak Hsc70 and Hsp70 immunoreactivities. In contrast, in the brains with MSA, numerous glial cytoplasmic inclusions (GCIs) were intensely immunostained with Hsc70, and strong Hsc70 immunoreactivity was also found in glial intranuclear inclusions (GNIs), neuronal cytoplasmic inclusions (NCIs) and neuronal intranuclear inclusions (NNIs) as well as dystrophic neurites. The immunolabeling pattern for Hsp70 in the MSA brains was slightly different from that of Hsc70, and Hsp70 immunoreactivity was observed in many reactive astrocytes as well as some glial and neuronal inclusions. Our results suggest that the widespread accumulation of Hsc70 and Hsp70 may occur in brains with MSA, and that Hsc70 and Hsp70 may be associated with the pathogenesis of MSA. PMID:17240362

  19. Experimental lead poisoning in bald eagles

    USGS Publications Warehouse

    Pattee, H.; Wiemeyer, S.; Hoffman, P.; Carpenter, J.; Sileo, L.

    1979-01-01

    Captive, crippled bald eagles unsuitable for release were fed lead shot to determine diagnostic criteria for lead poisoning. The eagles were fluoroscoped and bled periodically to determine shot retention and blood delta--aminolevulinic acid dehydratase activity. Microscopic examination revealed renal tubular degeneration, arterial fibrinoid necrosis and myocardial necrosis. Acid-fast intra-nuclear inclusion bodies were not found in proximal convoluted tubule cells. Analyses of blood and toxicological data are not yet complete.

  20. Experimental lead-shot poisoning in bald eagles

    USGS Publications Warehouse

    Pattee, O.H.; Wiemeyer, Stanley N.; Mulhern, B.M.; Sileo, L.; Carpenter, J.W.

    1981-01-01

    Captive, crippled bald eagles unsuitable for release were fed lead shot to determine diagnostic criteria for lead poisoning. The eagles were fluoroscoped and bled periodically to determine shot retention and blood delta--aminolevulinic acid dehydratase activity. Microscopic examination revealed renal tubular degeneration, arterial fibrinoid necrosis and myocardial necrosis. Acid-fast intra-nuclear inclusion bodies were not found in proximal convoluted tubule cells. Analyses of blood and toxicological data are not yet complete.

  1. Avian polyomavirus infection of a fledgling budgerigar (Melopsittacus undulatus) and differential diagnoses of viral inclusions in psittacine birds--case report and mini-review.

    PubMed

    Herder, Vanessa; König, Anett; Seehusen, Frauke; Wohlsein, Peter

    2011-01-01

    A two-week-old budgerigar (Melopsittacus undulatus) of an outdoor aviary died suddenly and was submitted for determination the cause of illness and death. Macroscopically, the sparsely feathered animal was in a poor body condition. Histopathological examination revealed in various mesenchymal and epithelial tissues, numerous up to 15 microm in diameter large intranuclear, amphophilic to basophilic inclusion bodies with a clearing of the centre. Additionally, a feather dysplasia and retention hyperkeratosis of feather follicles was found. Ultrastructurally, viral particles of approximately 35 nm in diameter were detected in the feather follicle epithelium. A PCR for Avian Polyomavirus on fresh skin samples was negative whereas on formalin-fixed kidney samples with a high amount of viral inclusion bodies yielded a positive result. In addition, viral inclusion body diseases, like Avian Poxvirus, Psittacine Beak and Feather disease virus, Avian Adenovirus, Psittacine Herpesvirus and papillomavirus of psittacines are summarized and compared in the present article. PMID:22059291

  2. Penile epidermal inclusion cyst.

    PubMed

    Saini, Pradeep; Mansoor, M N; Jalali, Sanjay; Sharma, Abhishek

    2010-07-01

    We report a case of epidermal inclusion cyst of penis in a five-year-old boy, who had presented to the outpatient department of our hospital. Epidermal inclusion cysts are benign lesions that can develop in any part of the body. However, the finding of an epidermal inclusion cyst in the penis is rare. The child was operated and discharged uneventfully. The objective of reporting this case is to highlight the rare possibility of an inclusion cyst arising from penis as a late complication of circumcision. PMID:20589475

  3. Extension of the Liège intranuclear cascade model at incident energies between 2 and 12 GeV. Aspects of pion production

    NASA Astrophysics Data System (ADS)

    Pedoux, Sophie; Cugnon, Joseph

    2011-09-01

    The validity of the standard version of the Liège Intra-Nuclear Cascade (INCL4) model, which has been shown to be quite successful for the description of spallation reactions, is limited to an upper incident energy of ˜2 GeV, because inelastic elementary processes are restricted to the excitation and de-excitation of the Delta resonance. In this paper, the INCL4 model is extended to higher incident energy by including other inelastic elementary collisions. However, excitation of heavier baryonic resonances is replaced by direct multipion production in elementary nucleon-nucleon and pion-nucleon collisions. The predictions of the modified model for production of charged pions by proton and pion beams off nuclei are compared with experimental data of the HARP Collaboration for beam energies between 2 and 12 GeV. The apparent duality between the approach based on excitation of numerous baryonic resonances and our approach is briefly discussed.

  4. Towards Inclusive Schooling.

    ERIC Educational Resources Information Center

    Ainscow, Mel

    1997-01-01

    Uses classroom vignettes to examine reasons why schools in the United Kingdom are not yet generally successful in including students with disabilities and suggests simple ways that ordinary teachers can implement inclusive practices. These include the importance of teamwork, a school climate which encourages inclusive practices, and teacher…

  5. Conclusions on Inclusion

    ERIC Educational Resources Information Center

    Fink, John

    2004-01-01

    An inclusion classroom is defined as one that is tasked with mainstreaming special education students into a population of general education students. In this brief article, the author, a high school mathematics teacher, shares his personal experiences in teaching in an inclusion classroom. A primary focus is his relationship with the special…

  6. The Inclusion Facilitator's Guide

    ERIC Educational Resources Information Center

    Jorgensen, Cheryl M.; Schuh, Mary C.; Nisbet, Jan

    2005-01-01

    Inclusion facilitators are educators who do more than teach children with disabilities--they advocate for change in schools and communities, sparking a passion for inclusion in teachers, administrators, and families and giving them the practical guidance they need to make it work. This is an essential new role in today's schools, and this guide…

  7. Teachers' Attitudes toward Inclusion

    ERIC Educational Resources Information Center

    Elhoweris, Hala; Alsheikh, Negmeldin

    2004-01-01

    The purpose of this study was to (a) investigate current teachers' attitudes toward inclusion, and to (b) explore possible difference in the general and special education teachers' attitudes toward inclusion of students with disabilities in the integrated education classroom. A total of 10 participants from a large mid-western state university…

  8. Fluid inclusion petrography

    NASA Astrophysics Data System (ADS)

    Van den Kerkhof, Alfons M.; Hein, Ulrich F.

    2001-01-01

    A procedure of fluid inclusion studies is proposed with emphasis on the criteria of selecting fluid inclusions for detailed (microthermometry and spectroscopic) analysis. An overview of descriptive and genetic classifications of fluid inclusions in single crystals and in massive rocks is given with the intention of further differentiating the commonly used terms 'primary' and 'secondary' fluid inclusions. Some principles of fluid inclusion modification are explained. Cathodoluminescence (CL) studies of quartz with the optical high-power CL-microscope and the electron microprobe provided with a CL detector are an important help in 'fluid petrography'. CL textures are subdivided in primary, growth textures and a wide variety of secondary microtextures, which are in part induced by fluid inclusions. The latter is grouped in textures indicative of local lower crystal order (increasing defect structures) and microtextures indicative of local quartz healing (reduction of the defect structures). Microtextures showing the genetic relationship between fluid inclusions and the host mineral provide information about the possible post-entrapment changes of fluid inclusions and therewith testify their geological relevance.

  9. Index for Inclusion

    ERIC Educational Resources Information Center

    Smith, Allister

    2005-01-01

    Index for Inclusion is a programme to assist in developing learning and participation in schools. It was written by Tony Booth and Mel Ainscow from the Centre for Studies on Inclusive Education, UK. Central Normal School was pleased to have the opportunity to trial this programme.

  10. What Counts as Inclusion?

    ERIC Educational Resources Information Center

    Walton, E.; Nel, N.

    2012-01-01

    In the years since the publication in South Africa of White Paper Six: Special needs education (Department of Education (DoE) 2001) various schools in the state and independent sectors have begun to implement inclusive policies and practices. With reference to the Guidelines for full-service/inclusive schools issued in 2009, and by discussing a…

  11. Understanding Inclusion in Cyprus

    ERIC Educational Resources Information Center

    Mamas, Christoforos

    2013-01-01

    This paper provides a framework for understanding inclusion in Cyprus. The evidence base is the result of a six-month qualitative research study in five Cypriot mainstream primary schools. Despite the rhetoric in favour of inclusion, it seems that the Cypriot educational system is still highly segregating in its philosophy and does not fully…

  12. Inclusive Services Innovation Configuration

    ERIC Educational Resources Information Center

    Holdheide, Lynn R.; Reschly, Daniel J.

    2011-01-01

    Teacher preparation to deliver inclusive services to students with disabilities is increasingly important because of changes in law and policy emphasizing student access to, and achievement in, the general education curriculum. This innovation configuration identifies the components of inclusive services that should be incorporated in teacher…

  13. Jet inclusive cross sections

    SciTech Connect

    Del Duca, V.

    1992-11-01

    Minijet production in jet inclusive cross sections at hadron colliders, with large rapidity intervals between the tagged jets, is evaluated by using the BFKL pomeron. We describe the jet inclusive cross section for an arbitrary number of tagged jets, and show that it behaves like a system of coupled pomerons.

  14. Fluid inclusion geothermometry

    USGS Publications Warehouse

    Cunningham, C.G., Jr.

    1977-01-01

    Fluid inclusions trapped within crystals either during growth or at a later time provide many clues to the histories of rocks and ores. Estimates of fluid-inclusion homogenization temperature and density can be obtained using a petrographic microscope with thin sections, and they can be refined using heating and freezing stages. Fluid inclusion studies, used in conjunction with paragenetic studies, can provide direct data on the time and space variations of parameters such as temperature, pressure, density, and composition of fluids in geologic environments. Changes in these parameters directly affect the fugacity, composition, and pH of fluids, thus directly influencing localization of ore metals. ?? 1977 Ferdinand Enke Verlag Stuttgart.

  15. Melt inclusions: Chapter 6

    USGS Publications Warehouse

    Audétat A.; Lowenstern, J. B.

    2014-01-01

    Melt inclusions are small droplets of silicate melt that are trapped in minerals during their growth in a magma. Once formed, they commonly retain much of their initial composition (with some exceptions) unless they are re-opened at some later stage. Melt inclusions thus offer several key advantages over whole rock samples: (i) they record pristine concentrations of volatiles and metals that are usually lost during magma solidification and degassing, (ii) they are snapshots in time whereas whole rocks are the time-integrated end products, thus allowing a more detailed, time-resolved view into magmatic processes (iii) they are largely unaffected by subsolidus alteration. Due to these characteristics, melt inclusions are an ideal tool to study the evolution of mineralized magma systems. This chapter first discusses general aspects of melt inclusions formation and methods for their investigation, before reviewing studies performed on mineralized magma systems.

  16. Minority Inclusion Programs.

    ERIC Educational Resources Information Center

    Gelfand, M. David

    1995-01-01

    Asserts that the United States has a long, sad history of discrimination against minority rights. Discusses the origins and history of minority inclusion or affirmative action programs. Includes a special report on the "English Only" movement. (CFR)

  17. Limitations of inclusive fitness.

    PubMed

    Allen, Benjamin; Nowak, Martin A; Wilson, Edward O

    2013-12-10

    Until recently, inclusive fitness has been widely accepted as a general method to explain the evolution of social behavior. Affirming and expanding earlier criticism, we demonstrate that inclusive fitness is instead a limited concept, which exists only for a small subset of evolutionary processes. Inclusive fitness assumes that personal fitness is the sum of additive components caused by individual actions. This assumption does not hold for the majority of evolutionary processes or scenarios. To sidestep this limitation, inclusive fitness theorists have proposed a method using linear regression. On the basis of this method, it is claimed that inclusive fitness theory (i) predicts the direction of allele frequency changes, (ii) reveals the reasons for these changes, (iii) is as general as natural selection, and (iv) provides a universal design principle for evolution. In this paper we evaluate these claims, and show that all of them are unfounded. If the objective is to analyze whether mutations that modify social behavior are favored or opposed by natural selection, then no aspect of inclusive fitness theory is needed. PMID:24277847

  18. Limitations of inclusive fitness

    PubMed Central

    Allen, Benjamin; Nowak, Martin A.; Wilson, Edward O.

    2013-01-01

    Until recently, inclusive fitness has been widely accepted as a general method to explain the evolution of social behavior. Affirming and expanding earlier criticism, we demonstrate that inclusive fitness is instead a limited concept, which exists only for a small subset of evolutionary processes. Inclusive fitness assumes that personal fitness is the sum of additive components caused by individual actions. This assumption does not hold for the majority of evolutionary processes or scenarios. To sidestep this limitation, inclusive fitness theorists have proposed a method using linear regression. On the basis of this method, it is claimed that inclusive fitness theory (i) predicts the direction of allele frequency changes, (ii) reveals the reasons for these changes, (iii) is as general as natural selection, and (iv) provides a universal design principle for evolution. In this paper we evaluate these claims, and show that all of them are unfounded. If the objective is to analyze whether mutations that modify social behavior are favored or opposed by natural selection, then no aspect of inclusive fitness theory is needed. PMID:24277847

  19. Hadronic event generation for hadron cascade calculations and detector simulation, Part IV: The application of the intranuclear cascade model to reactions of pions, nucleons, kaons, and their antiparticles with nuclei below 6 GeV/c

    SciTech Connect

    Haenbssgen, K.

    1987-02-01

    An extension of the intranuclear cascade model is described. The primary hadrons may be pions, kaons, nucleons, and their antiparticles. Secondary particles produced include hyperons or antihyperons. A large amount of experimental data is described by the model. The model is constructed via the Monte Carlo generation of complete events, based on a model of the nucleus structure and the hadron/nucleon interaction inside the nucleus. Calculated average multiplicities and single and double differential cross sections are compared with experimental data.

  20. Hydroxyurea-induced replication stress causes poly(ADP-ribose) polymerase-2 accumulation and changes its intranuclear location in root meristems of Vicia faba.

    PubMed

    Rybaczek, Dorota

    2016-07-01

    Replication stress induced by 24 and 48h exposure to 2.5mM hydroxyurea (HU) increased the activity of poly(ADP-ribose) polymerase-2 (PARP-2; EC 2.4.2.30) in root meristem cells of Vicia faba. An increase in the number of PARP-2 foci was accompanied by their delocalization from peripheral areas to the interior of the nucleus. Our results indicate that the increase in PARP-2 was connected with an increase in S139-phosphorylated H2AX histones. The findings suggest the possible role of PARP-2 in replication stress. We also confirm that the intranuclear location of PARP-2 depends on the duration of HU-induced replication stress, confirming the role of PARP-2 as an indicator of stress intensity. Finally, we conclude that the more intense the HU-mediated replication stress, the greater the probability of PARP-2 activation or H2AXS139 phosphorylation, but also the greater the chance of increasing the efficiency of repair processes and a return to normal cell cycle progression. PMID:27155387

  1. PICA95: An intranuclear-cascade code for 25-MeV to 3.5-GeV photon-induced nuclear reactions

    SciTech Connect

    Fu, C.Y.; Gabriel, T.A.; Lillie, R.A.

    1997-05-01

    PICA95, an intranuclear-cascade code for calculating photon-induced nuclear reactions for incident photon energies up to 3.5 GeV, is an extension of the original PICA code package that works for incident photon energies up to 400 MeV. The original code includes the quasi-deuteron breakup and single-pion production channels. The extension to an incident photon energy of 3.5 GeV requires the addition of multiple-pion production channels capable of emitting up to five pions. Relativistic phase-space relations are used to conserve energy and momentum in multi-body breakups. Fermi motion of the struck nucleon is included in the phase-space calculations as well as secondary nuclear collisions of the produced particles. Calculated doubly differential cross sections for the productions of protons, neutrons, {pi}{sup +}, {pi}{sup 0}, and {pi}{sup {minus}} for incident photon energies of 500 MeV, 1 GeV, and 2 GeV are compared with predictions by other codes. Due to the sparsity of experimental data, more experiments are needed in order to refine the gamma nuclear collision model.

  2. Novel inclusion in laser crystals

    SciTech Connect

    Ma Xiaoshan; Wang Siting; Jin Zhongru; Shen Yafang; Chen Jiaguang

    1986-12-01

    In growing alexandrite crystals, a novel inclusion has been found. The inclusions are quantitatively analyzed by an electronic probe and the mechanism for forming inclusions is suggested. In our Bridgman MgF/sub 2/ crystals, the inclusions in <001> direction have also been observed.

  3. Linguistic Diversity and Social Inclusion

    ERIC Educational Resources Information Center

    Piller, Ingrid; Takahashi, Kimie

    2011-01-01

    This introduction provides the framework for the special issue by describing the social inclusion agenda of neoliberal market democracies. While the social inclusion agenda has been widely adopted, social inclusion policies are often blind to the ways in which language proficiency and language ideologies mediate social inclusion in linguistically…

  4. Pure neuritic leprosy: Resolving diagnostic issues in acid fast bacilli (AFB)-negative nerve biopsies: A single centre experience from South India

    PubMed Central

    Hui, Monalisa; Uppin, Megha S.; Challa, Sundaram; Meena, A. K.; Kaul, Subhash

    2015-01-01

    Background and Purpose: Demonstration of lepra bacilli is essential for definite or unequivocal diagnosis of pure neuritic leprosy (PNL) on nerve biopsy. However, nerves always do not show bacilli owing to the changes of previous therapy or due to low bacillary load in tuberculoid forms. In absence of granuloma or lepra bacilli, other morphologic changes in endoneurium and perineurium can be of help in making a probable diagnosis of PNL and treating the patient with multidrug therapy. Materials and Methods: Forty-six biopsies of PNL were retrospectively reviewed and histologic findings were compared with 25 biopsies of non leprosy neuropathies (NLN) including vasculitic neuropathy and chronic inflammatory demyelinating polyneuropathy (CIDP). The distribution of endoneurial infiltrate and fibrosis, perineurial thickening, and myelin abnormalities were compared between PNL and NLN biopsies and analyzed by Chi-square test. Results: Out of 46 PNL casses, 24 (52.17 %) biopsies were negative for acid fast bacilli (AFB). In these cases, the features which favor a diagnosis of AFB-negative PNL were endoneurial infiltrate (51.1%), endoneurial fibrosis (54.2%), perineurial thickening (70.8%), and reduced number of myelinated nerve fibers (75%). Interpretation and Conclusion: Nerve biopsy is an efficient tool to diagnose PNL and differentiate it from other causes of NLN. In absence of AFB, the diagnosis of PNL is challenging. In this article, we have satisfactorily evaluated the various hisopthological features and found that endoneurial inflammation, dense fibrosis, and reduction in the number of myelinated nerve fibers are strong supportive indicators of PNL regardless of AFB positivity. PMID:26425006

  5. Evaluation of different modifications of acid-fast staining techniques and stool enzyme-linked immunosorbent assay in detecting fecal Cryptosporidium in diarrheic HIV seropositive and seronegative patients

    PubMed Central

    Parghi, Ekta; Dash, Lona; Shastri, Jayanthi

    2014-01-01

    Rational: The role of Cryptosporidium as an agent of human diarrhea has been redefined over the past decade following recognition of the strong association between cases of cryptosporidiosis and immune deficient individuals (such as those with AIDS). Purpose: The purpose of this study is to determine the prevalence of enteric parasites and to compare the diagnostic utility of stool enzyme-linked immunosorbent assay (ELISA) with various modifications of acid-fast (AF) staining in detection of Cryptosporidium in stool samples of diarrheic patients. Materials and Methods: Stool samples from 186 cases comprising of 93 HIV seropositive and 93 seronegative patients were included. These were subjected to routine and microscopic examination as well as various modifications of AF staining for detection of coccidian parasites and ELISA for the detection of Cryptosporidium. Results: The prevalence of enteric parasites was 54.8% and of Cryptosporidium was 17.2% in HIV seropositive patients while it was 29.0% and 5.4%, respectively in seronegative patients. Of the 186 cases, 33 cases (17.7%) were positive for Cryptosporidium by stool ELISA as compared to 21 (11.3%) by modified AF staining (gold standard) showing sensitivity and specificity of 100% and 92.7%, respectively. The maximum cases of Cryptosporidium (21; 11.3%) were detected by AF staining using 3% acid alcohol. Conclusion: ELISA is a simple, useful, and rapid tool for detection of Cryptosporidium in stool, especially for large scale population studies. However, the role of modified AF staining in detection of Cryptosporidium and other coccidian parasites is important. Based on the results of various modifications of AF staining, the present study recommends the use of 3% acid alcohol along with 10% H2SO4. PMID:25250230

  6. Improved Sensitivity of Sputum Smear Microscopy after Processing Specimens with C18-Carboxypropylbetaine To Detect Acid-Fast Bacilli: a Study of United States-Bound Immigrants from Vietnam

    PubMed Central

    Laserson, K. F.; Yen, N. T. N.; Thornton, C. G.; Mai, V. T. C.; Jones, W.; An, D. Q.; Phuoc, N. H.; Trinh, N. A.; Nhung, D. T. C.; Lien, T. X.; Lan, N. T. N.; Wells, C.; Binkin, N.; Cetron, M.; Maloney, S. A.

    2005-01-01

    The goal of this study was to evaluate the effect of the specimen-processing method that uses the detergent C18-carboxypropylbetaine (CB-18) on the sensitivity of acid-fast bacillus (AFB) staining. Vietnamese immigrants with abnormal chest radiographs provided up to three sputum specimens, which were examined for acid-fast bacilli by use of direct auramine and Ziehl-Neelsen staining. The remaining sputum was split; half was cultured, and the other half was incubated with CB-18 for 24 h, centrifuged, and examined for AFB by both staining methods. CB-18 processing improved the sensitivity of AFB staining by 20 to 30% (only differences in auramine sensitivity were statistically significant) but reduced specificity by ≈20% (P < 0.05). These findings have direct utility for overseas migrant tuberculosis screening programs, for which maximizing test sensitivity is a major objective. PMID:16000478

  7. Inclusion Body Myositis

    PubMed Central

    Dimachkie, Mazen M.; Barohn, Richard J.

    2012-01-01

    The idiopathic inflammatory myopathies are a group of rare disorders that share many similarities. These include dermatomyositis (DM), polymyositis (PM), necrotizing myopathy (NM), and sporadic inclusion body myositis (IBM). Inclusion body myositis is the most common idiopathic inflammatory myopathy after age 50 and it presents with chronic proximal leg and distal arm asymmetric mucle weakness. Despite similarities with PM, it is likely that IBM is primarily a degenerative disorder rather than an inflammatory muscle disease. Inclusion body myositis is associated with a modest degree of creatine kinase (CK) elevation and an abnormal electromyogram demonstrating an irritative myopathy with some chronicity. The muscle histopathology demonstrates inflammatory exudates surrounding and invading nonnecrotic muscle fibers often times accompanied by rimmed vacuoles. In this chapter, we review sporadic IBM. We also examine past, essentially negative, clinical trials in IBM and review ongoing clinical trials. For further details on DM, PM, and NM, the reader is referred to the idiopathic inflammatory myopathies chapter. PMID:23117948

  8. Effects of Deletion and Overexpression of the Autographa californica Nuclear Polyhedrosis Virus FP25K Gene on Synthesis of Two Occlusion-Derived Virus Envelope Proteins and Their Transport into Virus-Induced Intranuclear Membranes

    PubMed Central

    Rosas-Acosta, Germán; Braunagel, Sharon C.; Summers, Max D.

    2001-01-01

    Partial deletions within Autographa californica open reading frame 61 (FP25K) alter the expression and accumulation profile of several viral proteins and the transport of occlusion-derived virus (ODV)-E66 to intranuclear membranes during infection (S. C. Braunagel et al., J. Virol. 73:8559–8570, 1999). Here we show the effects of a full deletion and overexpression of FP25K on the transport and expression of two ODV envelope proteins, ODV-E66 (E66) and ODV-E25 (E25). Deletion and overexpression of FP25K substantially altered the levels of expression of E66 during infection. Compared with cells infected with wild-type (wt) virus, the levels of E66 were reduced fivefold in cells infected with a viral mutant lacking FP25K (ΔFP25K) and were slightly increased in cells infected with a viral mutant overexpressing FP25K (FP25Kpolh). In contrast, no significant changes were observed in the levels of E25 among wt-, ΔFP25K-, and FP25Kpolh-infected cells. The changes observed in the levels of E66 among the different viral mutants were not accompanied by changes in either the time of synthesis, membrane association, protein turnover, or steady-state transcript abundance. Deletion of FP25K also substantially altered the transport and localization of E66 during infection. In cells infected with the ΔFP25K mutant virus, E66 accumulated in localized regions at the nuclear periphery and the outer nuclear membrane and did not traffic to intranuclear membranes. In contrast, in cells infected with the FP25Kpolh mutant virus E66 trafficked to intranuclear membranes. For comparison, E25 was normally transported to intranuclear membranes in both ΔFP25K- and FP25Kpolh-infected cells. Altogether these studies suggest that FP25K affects the synthesis of E66 at a posttranscriptional level, probably by altering the translation of E66; additionally, the block in transport of E66 at the nuclear envelope in ΔFP25K-infected cells suggests that the pathway of E66 trafficking to the inner

  9. Inclusion Practice Priorities Instrument.

    ERIC Educational Resources Information Center

    Montie, Jo; And Others

    This instrument was developed to assist individuals or teams to review best practice indicators regarding the development of inclusive school communities and to establish priority targets for improvement. The instrument covers three areas: (1) school community issues, (2) team issues, and (3) classroom issues. For each area, there is a review…

  10. In Search of Inclusion

    ERIC Educational Resources Information Center

    Hunter, John; O'Connor, Una

    2006-01-01

    This article provides a context within which other contributions to this issue might be read. It examines the position of special educational needs (SEN) within the evolving continuum of education in Northern Ireland, specifically within the context of educational inclusion. It describes recent changes in educational policy and legislation which…

  11. Inclusion Art Contest

    ERIC Educational Resources Information Center

    Mel, Melisa Dauzat

    2010-01-01

    The purpose of this study was to ease a school system into the transitions that occur when Inclusion is incorporated. An entire Middle School was used to collect data from. The grades in that school were 6th, 7th and 8th grade. The initial intent was to foment a community feeling among the students. The results were completely unexpected as they…

  12. Exploring Inclusive Pedagogy

    ERIC Educational Resources Information Center

    Florian, Lani; Black-Hawkins, Kristine

    2011-01-01

    This paper reports on a study designed to examine teachers' craft knowledge of their practice of "inclusion" in terms of what they do, why and how. The research approach offers an important alternative to studies of students with "additional needs" and the search to articulate the specialist knowledge and skill required to teach them. Through…

  13. Inclusion on the Bookshelf

    ERIC Educational Resources Information Center

    Jackson, Camille

    2009-01-01

    Three decades have passed since federal law mandated inclusion--ending, officially at least, a system that segregated students with disabilities from the rest of the student population. The publishing world has yet to catch up. In children's books, characters with disabilities often inhabit their own separate world, where disability is the only…

  14. Nanotubular Toughening Inclusions

    NASA Technical Reports Server (NTRS)

    Park, Cheol (Inventor); Working, Dennis C. (Inventor); Siochi, Emilie J. (Inventor); Harrison, Joycelyn S. (Inventor)

    2015-01-01

    Conventional toughening agents are typically rubbery materials or small molecular weight molecules, which mostly sacrifice the intrinsic properties of a matrix such as modulus, strength, and thermal stability as side effects. On the other hand, high modulus inclusions tend to reinforce elastic modulus very efficiently, but not the strength very well. For example, mechanical reinforcement with inorganic inclusions often degrades the composite toughness, encountering a frequent catastrophic brittle failure triggered by minute chips and cracks. Thus, toughening generally conflicts with mechanical reinforcement. Carbon nanotubes have been used as efficient reinforcing agents in various applications due to their combination of extraordinary mechanical, electrical, and thermal properties. Moreover, nanotubes can elongate more than 20% without yielding or breaking, and absorb significant amounts of energy during deformation, which enables them to also be an efficient toughening agent, as well as excellent reinforcing inclusion. Accordingly, an improved toughening method is provided by incorporating nanotubular inclusions into a host matrix, such as thermoset and thermoplastic polymers or ceramics without detrimental effects on the matrix's intrinsic physical properties.

  15. Raising Achievement through Inclusion

    ERIC Educational Resources Information Center

    Persson, Elisabeth

    2013-01-01

    In 2007, Swedish authorities introduced open publication of comparisons of students' results at the end of compulsory school. In this study, we investigated a municipality that had succeeded in breaking a negative trend from a bottom position in the ranking in 2007 to a top position in 2010, apparently through inclusive practices. The purpose…

  16. Teaching Inclusion through Alphapoems.

    ERIC Educational Resources Information Center

    Murray, Susan "BOON"

    2000-01-01

    Describes what inclusion is and how people in the helping professions may unintentionally promote exclusion. Describes the author's use of alphapoems in a course to develop college students' affective learning and advocacy toward people with disabilities. Offers examples of students' work and concludes that alphapoems served to further pedagogical…

  17. Optimization of inclusive fitness.

    PubMed

    Grafen, Alan

    2006-02-01

    The first fully explicit argument is given that broadly supports a widespread belief among whole-organism biologists that natural selection tends to lead to organisms acting as if maximizing their inclusive fitness. The use of optimization programs permits a clear statement of what this belief should be understood to mean, in contradistinction to the common mathematical presumption that it should be formalized as some kind of Lyapunov or even potential function. The argument reveals new details and uncovers latent assumptions. A very general genetic architecture is allowed, and there is arbitrary uncertainty. However, frequency dependence of fitnesses is not permitted. The logic of inclusive fitness immediately draws together various kinds of intra-genomic conflict, and the concept of 'p-family' is introduced. Inclusive fitness is thus incorporated into the formal Darwinism project, which aims to link the mathematics of motion (difference and differential equations) used to describe gene frequency trajectories with the mathematics of optimization used to describe purpose and design. Important questions remain to be answered in the fundamental theory of inclusive fitness. PMID:16046225

  18. Clinical significance of smear positivity for acid-fast bacilli after ≥5 months of treatment in patients with drug-susceptible pulmonary tuberculosis

    PubMed Central

    Kang, Hyung Koo; Jeong, Byeong-Ho; Lee, Hyun; Park, Hye Yun; Jeon, Kyeongman; Huh, Hee Jae; Ki, Chang-Seok; Lee, Nam Yong; Koh, Won-Jung

    2016-01-01

    Abstract Patients with pulmonary tuberculosis (TB) with acid-fast bacilli (AFB)-positive sputum smear at 5 months or later during treatment are considered to be cases of treatment failure according to World Health Organization guidelines. This study evaluated the proportion, clinical characteristics, and significance of positive sputum smears after ≥5 months of standard treatment in patients with drug-susceptible pulmonary TB. This was a retrospective cohort study of 1611 patients with culture-confirmed drug-susceptible pulmonary TB who received standard anti-TB treatment from January 2009 to February 2014. Forty-one patients (2.5%) who were smear-positive after ≥5 months of treatment and 123 age- and sex-matched control patients were evaluated. Among the 41 smear-positive patients, culture of the sputum specimens yielded Mycobacterium tuberculosis (MTB) in 1 patient (2.4%), nontuberculous mycobacteria (NTM) in 7 (17.1%), and no growth in the remaining 33 patients (80.5%). Treatment was successfully completed in 40 patients (97.6%) with prolongation of the continuation phase regimens without change to second-line anti-TB treatment. In patients with smear positivity after ≥5 months of treatment compared with controls, cavitation on chest radiographs (53.7% vs. 25.2%, P = 0.001), bilateral involvement (51.2% vs. 30.1%, P = 0.01) and combined pleural effusion (26.8% vs. 10.6%, P = 0.01) were found more frequently at the time of treatment initiation, and paradoxical response occurred more commonly (19.5% vs. 3.3%, P = 0.002) during treatment. Smear-positive sputum after ≥5 months of standard anti-TB treatment was mainly because of nonviable MTB bacilli or NTM in patients with drug-susceptible pulmonary TB. AFB smear alone should not be used to assess treatment failure and careful examination of microbiologic status, including culture and drug susceptibility testing, is needed before making changes to retreatment regimens or empirical second

  19. Clinical significance of smear positivity for acid-fast bacilli after ≥5 months of treatment in patients with drug-susceptible pulmonary tuberculosis.

    PubMed

    Kang, Hyung Koo; Jeong, Byeong-Ho; Lee, Hyun; Park, Hye Yun; Jeon, Kyeongman; Huh, Hee Jae; Ki, Chang-Seok; Lee, Nam Yong; Koh, Won-Jung

    2016-08-01

    Patients with pulmonary tuberculosis (TB) with acid-fast bacilli (AFB)-positive sputum smear at 5 months or later during treatment are considered to be cases of treatment failure according to World Health Organization guidelines. This study evaluated the proportion, clinical characteristics, and significance of positive sputum smears after ≥5 months of standard treatment in patients with drug-susceptible pulmonary TB.This was a retrospective cohort study of 1611 patients with culture-confirmed drug-susceptible pulmonary TB who received standard anti-TB treatment from January 2009 to February 2014. Forty-one patients (2.5%) who were smear-positive after ≥5 months of treatment and 123 age- and sex-matched control patients were evaluated.Among the 41 smear-positive patients, culture of the sputum specimens yielded Mycobacterium tuberculosis (MTB) in 1 patient (2.4%), nontuberculous mycobacteria (NTM) in 7 (17.1%), and no growth in the remaining 33 patients (80.5%). Treatment was successfully completed in 40 patients (97.6%) with prolongation of the continuation phase regimens without change to second-line anti-TB treatment. In patients with smear positivity after ≥5 months of treatment compared with controls, cavitation on chest radiographs (53.7% vs. 25.2%, P = 0.001), bilateral involvement (51.2% vs. 30.1%, P = 0.01) and combined pleural effusion (26.8% vs. 10.6%, P = 0.01) were found more frequently at the time of treatment initiation, and paradoxical response occurred more commonly (19.5% vs. 3.3%, P = 0.002) during treatment.Smear-positive sputum after ≥5 months of standard anti-TB treatment was mainly because of nonviable MTB bacilli or NTM in patients with drug-susceptible pulmonary TB. AFB smear alone should not be used to assess treatment failure and careful examination of microbiologic status, including culture and drug susceptibility testing, is needed before making changes to retreatment regimens or empirical second-line anti

  20. A Honey Bee Hexamerin, HEX 70a, Is Likely to Play an Intranuclear Role in Developing and Mature Ovarioles and Testioles

    PubMed Central

    Martins, Juliana R.; Anhezini, Lucas; Dallacqua, Rodrigo P.; Simões, Zilá L. P.; Bitondi, Márcia M. G.

    2011-01-01

    Insect hexamerins have long been known as storage proteins that are massively synthesized by the larval fat body and secreted into hemolymph. Following the larval-to-pupal molt, hexamerins are sequestered by the fat body via receptor-mediated endocytosis, broken up, and used as amino acid resources for metamorphosis. In the honey bee, the transcript and protein subunit of a hexamerin, HEX 70a, were also detected in ovaries and testes. Aiming to identify the subcellular localization of HEX 70a in the female and male gonads, we used a specific antibody in whole mount preparations of ovaries and testes for analysis by confocal laser-scanning microscopy. Intranuclear HEX 70a foci were evidenced in germ and somatic cells of ovarioles and testioles of pharate-adult workers and drones, suggesting a regulatory or structural role. Following injection of the thymidine analog EdU we observed co-labeling with HEX 70a in ovariole cell nuclei, inferring possible HEX 70a involvement in cell proliferation. Further support to this hypothesis came from an injection of anti-HEX 70a into newly ecdysed queen pupae where it had a negative effect on ovariole thickening. HEX 70a foci were also detected in ovarioles of egg laying queens, particularly in the nuclei of the highly polyploid nurse cells and in proliferating follicle cells. Additional roles for this storage protein are indicated by the detection of nuclear HEX 70a foci in post-meiotic spermatids and spermatozoa. Taken together, these results imply undescribed roles for HEX 70a in the developing gonads of the honey bee and raise the possibility that other hexamerins may also have tissue specific functions. PMID:22205988

  1. A honey bee hexamerin, HEX 70a, is likely to play an intranuclear role in developing and mature ovarioles and testioles.

    PubMed

    Martins, Juliana R; Anhezini, Lucas; Dallacqua, Rodrigo P; Simões, Zilá L P; Bitondi, Márcia M G

    2011-01-01

    Insect hexamerins have long been known as storage proteins that are massively synthesized by the larval fat body and secreted into hemolymph. Following the larval-to-pupal molt, hexamerins are sequestered by the fat body via receptor-mediated endocytosis, broken up, and used as amino acid resources for metamorphosis. In the honey bee, the transcript and protein subunit of a hexamerin, HEX 70a, were also detected in ovaries and testes. Aiming to identify the subcellular localization of HEX 70a in the female and male gonads, we used a specific antibody in whole mount preparations of ovaries and testes for analysis by confocal laser-scanning microscopy. Intranuclear HEX 70a foci were evidenced in germ and somatic cells of ovarioles and testioles of pharate-adult workers and drones, suggesting a regulatory or structural role. Following injection of the thymidine analog EdU we observed co-labeling with HEX 70a in ovariole cell nuclei, inferring possible HEX 70a involvement in cell proliferation. Further support to this hypothesis came from an injection of anti-HEX 70a into newly ecdysed queen pupae where it had a negative effect on ovariole thickening. HEX 70a foci were also detected in ovarioles of egg laying queens, particularly in the nuclei of the highly polyploid nurse cells and in proliferating follicle cells. Additional roles for this storage protein are indicated by the detection of nuclear HEX 70a foci in post-meiotic spermatids and spermatozoa. Taken together, these results imply undescribed roles for HEX 70a in the developing gonads of the honey bee and raise the possibility that other hexamerins may also have tissue specific functions. PMID:22205988

  2. Developing Inclusive Teachers from an Inclusive Curricular Perspective

    ERIC Educational Resources Information Center

    Opertti, Renato; Brady, Jayne

    2011-01-01

    This article defines inclusive education in light of the Education for All agenda. It then describes key considerations for developing inclusive teachers from the perspective of an inclusive curriculum which seeks to address the needs of all learners. It concludes by outlining several key policy discussion areas which must be addressed if…

  3. Inclusive Education in Italy: Description and Reflections on Full Inclusion

    ERIC Educational Resources Information Center

    Anastasiou, Dimitris; Kauffman, James M.; Di Nuovo, Santo

    2015-01-01

    Inclusion of students with disabilities when appropriate is an important goal of special education for students with special needs. Full inclusion, meaning no education for any child in a separate setting, is held to be desirable by some, and Italy is likely the nation with an education system most closely approximating full inclusion on the…

  4. Inclusion-Body Myositis: Diagnosis

    MedlinePlus

    ... How to Get Involved Donate Inclusion-Body Myositis (IBM) Share print email share facebook twitter google plus ... Causes/Inheritance Medical Management Research Inclusion-Body Myositis (IBM) News Gene Therapy Success in IBM- A Quest ...

  5. Inclusive Education in South Korea

    ERIC Educational Resources Information Center

    Kim, Yong-Wook

    2014-01-01

    The purpose of this paper is to examine the current implementation of inclusive education in South Korea and discuss its challenges. The history of special education is first described followed by an introduction to policies relevant to special and inclusive education. Next, a critical discussion of the state of inclusive education follows built…

  6. Brief, Amazing Moments of Inclusion

    ERIC Educational Resources Information Center

    Fialka, Janice

    2005-01-01

    "Real inclusion" of kinds with special needs occurs everywhere, inside the classroom as well as outside. This is a fairly basic principle, however, it is not always easy to achieve. In this article, the author describes how her family have had to "fight" for inclusive education and shares some amazing moments of inclusion with her son Micah.

  7. How to measure inclusive fitness.

    PubMed

    Creel, S

    1990-09-22

    Although inclusive fitness (Hamilton 1964) is regarded as the basic currency of natural selection, difficulty in applying inclusive fitness theory to field studies persists, a quarter-century after its introduction (Grafen 1982, 1984; Brown 1987). For instance, strict application of the original (and currently accepted) definition of inclusive fitness predicts that no one should ever attempt to breed among obligately cooperative breeders. Much of this confusion may have arisen because Hamilton's (1964) original verbal definition of inclusive fitness was not in complete accord with his justifying model. By re-examining Hamilton's original model, a modified verbal definition of inclusive fitness can be justified. PMID:1979447

  8. Singing and social inclusion.

    PubMed

    Welch, Graham F; Himonides, Evangelos; Saunders, Jo; Papageorgi, Ioulia; Sarazin, Marc

    2014-01-01

    There is a growing body of neurological, cognitive, and social psychological research to suggest the possibility of positive transfer effects from structured musical engagement. In particular, there is evidence to suggest that engagement in musical activities may impact on social inclusion (sense of self and of being socially integrated). Tackling social exclusion and promoting social inclusion are common concerns internationally, such as in the UK and the EC, and there are many diverse Government ministries and agencies globally that see the arts in general and music in particular as a key means by which social needs can be addressed. As part of a wider evaluation of a national, Government-sponsored music education initiative for Primary-aged children in England ("Sing Up"), opportunity was taken by the authors, at the request of the funders, to assess any possible relationship between (a) children's developing singing behavior and development and (b) their social inclusion (sense of self and of being socially integrated). Subsequently, it was possible to match data from n = 6087 participants, drawn from the final 3 years of data collection (2008-2011), in terms of each child's individually assessed singing ability (based on their singing behavior of two well-known songs to create a "normalized singing score") and their written responses to a specially-designed questionnaire that included a set of statements related to children's sense of being socially included to which the children indicated their level of agreement on a seven-point Likert scale. Data analyses suggested that the higher the normalized singing development rating, the more positive the child's self-concept and sense of being socially included, irrespective of singer age, sex and ethnicity. PMID:25120514

  9. Singing and social inclusion

    PubMed Central

    Welch, Graham F.; Himonides, Evangelos; Saunders, Jo; Papageorgi, Ioulia; Sarazin, Marc

    2014-01-01

    There is a growing body of neurological, cognitive, and social psychological research to suggest the possibility of positive transfer effects from structured musical engagement. In particular, there is evidence to suggest that engagement in musical activities may impact on social inclusion (sense of self and of being socially integrated). Tackling social exclusion and promoting social inclusion are common concerns internationally, such as in the UK and the EC, and there are many diverse Government ministries and agencies globally that see the arts in general and music in particular as a key means by which social needs can be addressed. As part of a wider evaluation of a national, Government-sponsored music education initiative for Primary-aged children in England (“Sing Up”), opportunity was taken by the authors, at the request of the funders, to assess any possible relationship between (a) children's developing singing behavior and development and (b) their social inclusion (sense of self and of being socially integrated). Subsequently, it was possible to match data from n = 6087 participants, drawn from the final 3 years of data collection (2008–2011), in terms of each child's individually assessed singing ability (based on their singing behavior of two well-known songs to create a “normalized singing score”) and their written responses to a specially-designed questionnaire that included a set of statements related to children's sense of being socially included to which the children indicated their level of agreement on a seven-point Likert scale. Data analyses suggested that the higher the normalized singing development rating, the more positive the child's self-concept and sense of being socially included, irrespective of singer age, sex and ethnicity. PMID:25120514

  10. Ultrastructural studies of H-1 parvovirus replication. V. Immunocytochemical demonstration of separate chromatin-associated and inclusion-associated antigens.

    PubMed Central

    Singer, I I; Rhode, S L

    1977-01-01

    Electron microscopy and immunocytochrome c staining were used to define the phenotypes of several temperature-sensitive (ts) H-1 mutants. They were classified into three separate groups based on the properties of their capsids at the restrictive temperature (rT): (class 1) ts2 did not assemble capsids but produced spherical and irregular amorphous inclusions; (class 2) ts1 and ts7 exclusively synthesized empty particles which all aggregated and crystallized; and (class 3) ts8 and ts10 formed noncrystalline aggregates of empty virions, but many individual full, as well as empty, capsids were associated with euchromatin. Synthesis of progeny DNA and hemagglutinin at rT were normal for class 3 mutants, but defective for those in classes 1 and 2. The immunospecific staining patterns of these mutants indicated that the H-1 capsid proteins probably form two separate intranuclear antigens: (i) a thermostable chromatin-associated antigen present in proteins that have not formed capsids and are concentrated on heterochromatin and nucleolar-associated chromatin and (ii) a thermolabile inclusion-associated antigen found in the proteins of assembled empty capsids that compose H-1 inclusions. Images PMID:904027

  11. Can We Build Inclusion?

    PubMed

    Kirkeby, Inge Mette; Grangaard, Sidse

    2016-01-01

    Inclusion of children with special needs in kindergartens and preschools may be approached from different angles. This paper raises the question of whether the physical framework of kindergartens makes any difference for daily life at the kindergarten at all, and whether it can support inclusion of some children with special needs. Hence the title - can we build inclusion? In the literature of Universal Design, accommodation and design features seldom reflect the less visible disabilities. The paper is based on a research project initiated to investigate how more or less space influences daily pedagogical practice in general. Twelve interviews were conducted with experienced teachers from twelve different kindergartens with different amounts of space, varying from a ratio of 2.1 m2 play area per child to 5.5 m2. The results indicated that, for a group of children with special needs in particular, the amount of space is crucial. This group consisted of children who were socially very extrovert, and who maybe were noisy, easily provoked, and quick to get involved in arguments with other children. Alternatively, children in the group were very restrained and withdrawn in social interaction. Based on the answers in the interviews, we found support for answering the question in the title in the affirmative; we can build inclusion! This is because the teachers' experience indicated that, if there was sufficient space per child, there were fewer conflicts and the children managed to stay in the same activity for a much longer period. Sufficient space made it possible to divide the children into smaller groups, and use any secluded space. Therefore, it was much easier for other children to include some children with special needs. Accordingly, we can say that, sufficient space per child and an adequate layout and furnishing of the kindergarten is an advantage for all children. This is a clear example of Universal Design in which architectural

  12. Inclusive and Exclusive |Vub|

    SciTech Connect

    Petrella, Antonio; /Ferrara U. /INFN, Ferrara

    2011-11-17

    The current status of the determinations of CKM matrix element |V{sub ub}| via exclusive and inclusive charmless semileptonic B decays is reviewed. The large datasets collected at the B-Factories, and the increased precision of theoretical calculations have allowed an improvement in the determination of |V{sub ub}|. However, there are still significant uncertainties. In the exclusive approach, the most precise measurement of the pion channel branching ratio is obtained by an untagged analysis. This very good precision can be reached by tagged analyses with more data. The problem with exclusive decays is that the strong hadron dynamics can not be calculated from first principles and the determination of the form factor has to rely on light-cone sum rules or lattice QCD calculations. The current data samples allow a comparison of different FF models with data distributions. With further developments on lattice calculations, the theoretical error should shrink to reach the experimental one. The inclusive approach still provides the most precise |V{sub ub}| determinations. With new theoretical calculations, the mild (2.5{sigma}) discrepancy with respect to the |V{sub ub}| value determined from the global UT fit has been reduced. As in the exclusive approach, theoretical uncertainties represent the limiting factor to the precision of the measurement. Reducing the theoretical uncertainties to a level comparable with the statistical error is challenging. New measurements in semileptonic decays of charm mesons could increase the confidence in theoretical calculations and related uncertainties.

  13. [Inclusion-body myositis].

    PubMed

    Benveniste, O

    2014-07-01

    Sporadic inclusion-body myositis (sIBM) presents in average at the sixth decade of life and affects three men for one woman. It is a non-lethal, slowly progressive but disabling disease. Except the striated muscles, no other organs (such as the interstitial lung) are involved. The phenotype of this myopathy is particular since it involves the axial muscles (camptocormia, swallowing dysfunction) and limb girdle (notably the quadriceps) but also the distal muscles (in particular the fingers' and wrists' flexors) in a bilateral but non-symmetrical manner. The clinical presentation is then very suggestive of the diagnosis, which remains to be proven by a muscle biopsy. Histological features defining the diagnosis associate endomysial inflammatory infiltrates with frequent invaded fibres (the myositis) and amyloid deposits generally accompanying rimmed vacuoles (the inclusions). There is still today a debate to know if this disease is at its beginning a degenerative or an auto-immune condition. Nonetheless, usual immunosuppressive drugs (corticosteroids, azathioprine, methotrexate) or polyvalent immunoglobulines remain ineffective and even may worsen the handicap. Some controlled randomized trials will soon be launched for this condition, but for now, the best therapeutic approach to slow down the rapidity of progression of the disease is to maintain muscle exercise with the help of the physiotherapists. PMID:24128435

  14. Asymmetric inclusion process

    NASA Astrophysics Data System (ADS)

    Reuveni, Shlomi; Eliazar, Iddo; Yechiali, Uri

    2011-10-01

    We introduce and explore the asymmetric inclusion process (ASIP), an exactly solvable bosonic counterpart of the fermionic asymmetric exclusion process (ASEP). In both processes, random events cause particles to propagate unidirectionally along a one-dimensional lattice of n sites. In the ASEP, particles are subject to exclusion interactions, whereas in the ASIP, particles are subject to inclusion interactions that coalesce them into inseparable clusters. We study the dynamics of the ASIP, derive evolution equations for the mean and probability generating function (PGF) of the sites’ occupancy vector, obtain explicit results for the above mean at steady state, and describe an iterative scheme for the computation of the PGF at steady state. We further obtain explicit results for the load distribution in steady state, with the load being the total number of particles present in all lattice sites. Finally, we address the problem of load optimization, and solve it under various criteria. The ASIP model establishes bridges between statistical physics and queueing theory as it represents a tandem array of queueing systems with (unlimited) batch service, and a tandem array of growth-collapse processes.

  15. Inclusive fitness in agriculture

    PubMed Central

    Kiers, E. Toby; Denison, R. Ford

    2014-01-01

    Trade-offs between individual fitness and the collective performance of crop and below-ground symbiont communities are common in agriculture. Plant competitiveness for light and soil resources is key to individual fitness, but higher investments in stems and roots by a plant community to compete for those resources ultimately reduce crop yields. Similarly, rhizobia and mycorrhizal fungi may increase their individual fitness by diverting resources to their own reproduction, even if they could have benefited collectively by providing their shared crop host with more nitrogen and phosphorus, respectively. Past selection for inclusive fitness (benefits to others, weighted by their relatedness) is unlikely to have favoured community performance over individual fitness. The limited evidence for kin recognition in plants and microbes changes this conclusion only slightly. We therefore argue that there is still ample opportunity for human-imposed selection to improve cooperation among crop plants and their symbionts so that they use limited resources more efficiently. This evolutionarily informed approach will require a better understanding of how interactions among crops, and interactions with their symbionts, affected their inclusive fitness in the past and what that implies for current interactions. PMID:24686938

  16. Inclusive fitness in agriculture.

    PubMed

    Kiers, E Toby; Denison, R Ford

    2014-05-19

    Trade-offs between individual fitness and the collective performance of crop and below-ground symbiont communities are common in agriculture. Plant competitiveness for light and soil resources is key to individual fitness, but higher investments in stems and roots by a plant community to compete for those resources ultimately reduce crop yields. Similarly, rhizobia and mycorrhizal fungi may increase their individual fitness by diverting resources to their own reproduction, even if they could have benefited collectively by providing their shared crop host with more nitrogen and phosphorus, respectively. Past selection for inclusive fitness (benefits to others, weighted by their relatedness) is unlikely to have favoured community performance over individual fitness. The limited evidence for kin recognition in plants and microbes changes this conclusion only slightly. We therefore argue that there is still ample opportunity for human-imposed selection to improve cooperation among crop plants and their symbionts so that they use limited resources more efficiently. This evolutionarily informed approach will require a better understanding of how interactions among crops, and interactions with their symbionts, affected their inclusive fitness in the past and what that implies for current interactions. PMID:24686938

  17. Inclusive Jets in PHP

    NASA Astrophysics Data System (ADS)

    Roloff, P.

    Differential inclusive-jet cross sections have been measured in photoproduction for boson virtualities Q^2 < 1 GeV^2 with the ZEUS detector at HERA using an integrated luminosity of 300 pb^-1. Jets were identified in the laboratory frame using the k_T, anti-k_T or SIScone jet algorithms. Cross sections are presented as functions of the jet pseudorapidity, eta(jet), and the jet transverse energy, E_T(jet). Next-to-leading-order QCD calculations give a good description of the measurements, except for jets with low E_T(jet) and high eta(jet). The cross sections have the potential to improve the determination of the PDFs in future QCD fits. Values of alpha_s(M_Z) have been extracted from the measurements based on different jet algorithms. In addition, the energy-scale dependence of the strong coupling was determined.

  18. Possibilities for an Inclusive Society in Singapore: Becoming Inclusive within

    ERIC Educational Resources Information Center

    Lim, Levan

    2009-01-01

    The envisioning of Singapore as an inclusive society has witnessed the most progressive systemic and policy developments concerning people with disabilities in recent years. The building of "heartware" in society (as in the will, values, and attitudes of its citizens) in order to realize the vision of an inclusive society, however, requires both…

  19. Student Teachers' Attitudes and Beliefs about Inclusion and Inclusive Practice

    ERIC Educational Resources Information Center

    Beacham, Nigel; Rouse, Martyn

    2012-01-01

    The beliefs and attitudes of teachers are an important element in the development of inclusive education and its associated practices. Teacher education is seen as crucial in helping to develop positive attitudes and beliefs that are thought to promote inclusion, although attempts to reform teacher education in order to address issues of inclusion…

  20. Inclusive Education: Identifying Teachers' Perceived Stressors in Inclusive Classrooms

    ERIC Educational Resources Information Center

    Brackenreed, Darlene

    2008-01-01

    This research replicates the study conducted by Forlin (2001) in Churchlands, Western Australia. Forlin's Inclusive Education Teacher Stress and Coping Questionnaire was adapted from the original questionnaire to more accurately reflect the language and practice of inclusion in Ontario (Frost & Brackenreed, 2004). The purpose of this study was to…

  1. Social Inclusion and Metrolingual Practices

    ERIC Educational Resources Information Center

    Otsuji, Emi; Pennycook, Alastair

    2011-01-01

    In this paper, we explore the implications of metrolingual language practices for how we understand social inclusion. A vision of social inclusion that includes bi- and multilingual capacities may comprise an appreciation of a diversity of languages other than English, and the skills and capabilities of multilingual language users, yet it is all…

  2. Serbian Teachers' Attitudes towards Inclusion

    ERIC Educational Resources Information Center

    Kalyva, Efrosini; Gojkovic, Dina; Tsakiris, Vlastaris

    2007-01-01

    This study investigated the attitudes of 72 Serbian teachers towards the inclusion of children with Special Educational Needs (SEN) in mainstream schools; they were asked to complete "My Thinking About Inclusion Questionnaire" (Stoiber, Goettinger, & Goetz, 1998). It was found that Serbian teachers held overall slightly negative attitudes towards…

  3. Principals Influence Culture of Inclusion.

    ERIC Educational Resources Information Center

    King, Sophia

    2000-01-01

    Three New American High Schools (in Pittsburgh, Baltimore, and Greenbelt, Maryland) have successfully replaced the special-education culture of separation with a culture of inclusion. A large part of moving from self-contained practices to inclusion was helping students become self-advocates, so that the world outside school and home would not…

  4. In Support of Unfinished Inclusion

    ERIC Educational Resources Information Center

    Hausstätter, Rune Sarromaa

    2014-01-01

    This article claims that the radical potential inherent in the origins of inclusive education has been altered into a tool for protecting the status quo. Drawing on ideas from the essay "The Unfinished" by Thomas Mathiesen (1971), I discuss inclusion as a potential alternative to mainstream education and argue that the potential power of…

  5. Building Inclusive Cities and Communities

    ERIC Educational Resources Information Center

    Freiler, Christa

    2008-01-01

    Canada prides itself on being an inclusive country. Immigrants from all over the world arrive in Canada's cities with their families because they feel welcome and safe. According to research, engagement towards social inclusion increased among Canadians during the last 30 last years. These changing values resulted in the creation of official…

  6. Friendship in Inclusive Physical Education

    ERIC Educational Resources Information Center

    Seymour, Helena; Reid, Greg; Bloom, Gordon A.

    2009-01-01

    Social interaction and development of friendships between children with and without a disability are often proposed as potential outcomes of inclusive education. Physical activity specialists assert that exercise and sport environments may be conducive to social and friendship outcomes. This study investigated friendship in inclusive physical…

  7. Stiffening solids with liquid inclusions

    NASA Astrophysics Data System (ADS)

    Style, Robert W.; Boltyanskiy, Rostislav; Allen, Benjamin; Jensen, Katharine E.; Foote, Henry P.; Wettlaufer, John S.; Dufresne, Eric R.

    2015-01-01

    From bone and wood to concrete and carbon fibre, composites are ubiquitous natural and synthetic materials. Eshelby’s inclusion theory describes how macroscopic stress fields couple to isolated microscopic inclusions, allowing prediction of a composite’s bulk mechanical properties from a knowledge of its microstructure. It has been extended to describe a wide variety of phenomena from solid fracture to cell adhesion. Here, we show experimentally and theoretically that Eshelby’s theory breaks down for small liquid inclusions in a soft solid. In this limit, an isolated droplet’s deformation is strongly size-dependent, with the smallest droplets mimicking the behaviour of solid inclusions. Furthermore, in opposition to the predictions of conventional composite theory, we find that finite concentrations of small liquid inclusions enhance the stiffness of soft solids. A straightforward extension of Eshelby’s theory, accounting for the surface tension of the solid-liquid interface, explains our experimental observations. The counterintuitive stiffening of solids by fluid inclusions is expected whenever inclusion radii are smaller than an elastocapillary length, given by the ratio of the surface tension to Young’s modulus of the solid matrix. These results suggest that surface tension can be a simple and effective mechanism to cloak the far-field elastic signature of inclusions.

  8. Promoting a Lifetime of Inclusion.

    ERIC Educational Resources Information Center

    Renzaglia, Adelle; Karvonen, Meagan; Drasgow, Erik; Stoxen, Craig C.

    2003-01-01

    Discussion of ways to promote inclusion for individuals with severe disabilities first establishes the principle of normalization, then describes conditions and practices that reflect this principle and foster inclusion across the life span. These include universal design, person-centered planning, self-determination, and positive behavior…

  9. Early Childhood Inclusion in Turkey

    ERIC Educational Resources Information Center

    Diken, Ibrahim H.; Rakap, Salih; Diken, Ozlem; Tomris, Gozde; Celik, Secil

    2016-01-01

    Inclusion of young children with disabilities into regular preschool classrooms is a common practice that has been implemented for several decades in industrialized nations around the world, and many developing countries including Turkey have been developing and implementing laws, regulation, and services to support inclusion and teaching in…

  10. Inclusion in Malaysian Integrated Preschools

    ERIC Educational Resources Information Center

    Sukumaran, Sailajah; Loveridge, Judith; Green, Vanessa A.

    2015-01-01

    Inclusive education has been introduced through a number of policy developments in Malaysia over the last 10 years but there is little research investigating the extent and nature of inclusive education for preschoolers with special educational needs (SEN). This study surveyed both regular and special education teachers in Malaysian integrated…

  11. Fluid Inclusions in Carbonaceous Chondrites

    NASA Technical Reports Server (NTRS)

    Saylor, J.; Zolensky, M. E.; Bodnar, R. J.; Le L.; Schwandt, C.

    2001-01-01

    Fluid inclusions are present in carbonaceous chondrites. Of the chondrites studied (CI1, CM1 and 2, CV3) fluid inclusions were found only in CM2s and CI1s, and by extrapolation are most likely to be found there in the future. Additional information is contained in the original extended abstract.

  12. Quality in Inclusive Preschool Classrooms

    ERIC Educational Resources Information Center

    Hestenes, Linda L.; Cassidy, Deborah J.; Shim, Jonghee; Hegde, Archana V.

    2008-01-01

    Research Findings: Quality of care for preschool children in inclusive and noninclusive classrooms was examined in two studies. In Study 1, comparisons across a large sample of classrooms (N = 1, 313) showed that inclusive classrooms were higher than noninclusive classrooms in global quality as well as on two dimensions of quality…

  13. Inclusion Kinetics of Polyrotaxanes

    NASA Astrophysics Data System (ADS)

    Yokoyama, Hideaki; Takahashi, Shoko; Ito, Kohzo; Yamada, Norifumi

    Inclusion complex (IC) formation of α-cyclodextrin (α-CD) and poly(ethylene glycol) (PEG) brush in water was investigated by Surface Plasmon Resonance Spectroscopy(SPR), neutron reflectometry(NR) and grazing incident wide angle X-ray scattering(GISANS). Spontaneous IC formation of α-CD with PEG (polyrotaxanes) is believed to be due to hydrophobic interaction between the hydrophobic interior of α-CD and PEG; however, the detail of the IC formation kinetics has not been observed because IC formation results in aggregation and precipitation of the complex. SPR revealed that IC formation occurs after induction period, which often appears in crystallization. When concentration of α-CD solution is 10%, IC consisting randomly oriented α-CD polycrystal appeared. In contrast, when the concentration of α-CD solution is 5%, a uniform 10-nm-thick IC layer with α-CD stacked perpendicular to the substrate appeared. 10-nm-thick IC was also found in the diluted PEG brush in contact with a 10% α-CD solution. The characteristic 10-nm-thick layer is related to the folded crystalline structure of α-CD on PEG brush. Such crystallization was proved to be the main driving force for IC formation.

  14. Inclusion Body Myositis

    PubMed Central

    Barohn, Richard J.

    2014-01-01

    The idiopathic inflammatory myopathies (IIM) are a heterogenous group of rare disorders that share many similarities. In addition to sporadic inclusion body myositis (IBM), these include dematomyositis (DM), polymyositis (PM), and autoimmune necrotizing myopathy (NM). For discussion of later three disorders, the reader is referred to the IIM review in this issue. IBM is the most common IIM after age 50. It typically presents with chronic insidious proximal leg and/or distal arm asymmetric muscle weakness leading to recurrent falls and loss of dexterity. Creatine kinase (CK) is up to 15 times elevated in IBM and needle electromyograhy (EMG) mostly shows a chronic irritative myopathy. Muscle histopathology demonstrates endomysial inflammatory exudates surrounding and invading non-necrotic muscle fibers often times accompanied by rimmed vacuoles and protein deposits. Despite inflammatory muscle pathology suggesting similarity with PM, it likely that IBM is has a prominent degenerative component as supported by refractoriness to immunosuppressive therapy. We review the evolution of our knowledge in IBM with emphasis on recent developments in the field and discuss ongoing clinical trials. PMID:25037082

  15. The dynamism of PABPN1 nuclear inclusions during the cell cycle.

    PubMed

    Marie-Josée Sasseville, A; Caron, Antoine W; Bourget, Lucie; Klein, Arnaud F; Dicaire, Marie-Josée; Rouleau, Guy A; Massie, Bernard; Langelier, Yves; Brais, Bernard

    2006-09-01

    Oculopharyngeal muscular dystrophy (OPMD) is caused by expansion of a (GCN)10 to a (GCN)11-17 repeat coding for a polyalanine domain at the N-terminal part of poly(A) binding protein nuclear 1 (PABPN1). OPMD is characterized by the presence of intranuclear inclusions (INIs) in skeletal muscle fibers of patients. The formation of GFP-b13AlaPABPN1 INIs and their fate through the cell cycle were followed by time-lapse imaging. Our observations demonstrated that the GFP-b13AlaPABPN1 INIs are dynamic structures that can disassemble during mitosis. However, their presence in cells occasionally led to apoptosis. The length of the polyalanine tail or the overexpression of PABPN1 did not significantly affect the percentage of soluble PABPN1 in vitro. Moreover, overexpression of either the wild type (wt) or mutant (mut) forms of PABPN1 slowed down the cell proliferation. The slowing down of proliferation together with the occasional occurrence of apoptosis could contribute in vivo to the late onset of this disease. PMID:16860991

  16. The infidelity of melt inclusions?

    NASA Astrophysics Data System (ADS)

    Kent, A. J.

    2008-12-01

    Melt inclusions provide important information about magmatic systems and represent unique records of magma composition and evolution. However, it is also clear that melt inclusions do not necessarily constitute a petrological 'magic bullet', and potential exists for trapped melt compositions to be modified by a range of inclusion-specific processes. These include trapping of diffusional boundary layers, crystallization of the host mineral after trapping and dissolution of co-trapped minerals during homogenization, diffusional exchange between trapped liquid and the host mineral and external melt, and cryptic alteration of trapped material during weathering or hydrothermal alteration. It clearly important to identify when melt inclusions are unmodified, and which compositional indices represent the most robust sources of petrogenetic information. In this presentation I review and discuss various approaches for evaluating compositions and compositional variations in inclusion suites. An overriding principle is that the variations evident in melt inclusions should be able to be understood in terms of petrological processes that are known, or can be reasonably inferred to also effect bulk magma compositions. One common approach is to base petrological conclusions on species that should be more robust, and many workers use variations in incompatible trace elements for this purpose. However important information may also be obtained from a comparison of variations in melt inclusions and the lavas that host them, and in most cases this comparison is the key to identifying inclusions and suites that are potentially suspect. Comparisons can be made between individual inclusions and lavas, although comparison of average inclusion composition and the host lava, after correction for differences in crystal fractionation, may also be valuable. An important extension of this is the comparison of the variability of different species in inclusions and host lavas. This also provides

  17. Nontraditional Student Perceptions of Collegiate Inclusion

    ERIC Educational Resources Information Center

    Witkowsky, Patricia; Mendez, Sylvia; Ogunbowo, Oluwafolakemi; Clayton, Grant; Hernandez, Nancy

    2016-01-01

    This study explored student responses to a Student Inclusiveness Survey (SIS), with specific attention to nontraditional student responses about collegiate inclusion. Specifically, the SIS constructs that related to inclusion, the Perceptions of Inclusiveness and Institutional Safeguarding of Inclusiveness, were analyzed descriptively, and…

  18. Huntington's disease (HD): degeneration of select nuclei, widespread occurrence of neuronal nuclear and axonal inclusions in the brainstem.

    PubMed

    Rüb, Udo; Hentschel, Matthias; Stratmann, Katharina; Brunt, Ewout; Heinsen, Helmut; Seidel, Kay; Bouzrou, Mohamed; Auburger, Georg; Paulson, Henry; Vonsattel, Jean-Paul; Lange, Herwig; Korf, Horst-Werner; den Dunnen, Wilfred

    2014-04-01

    Huntington's disease (HD) is a progressive polyglutamine disease that leads to a severe striatal and layer-specific neuronal loss in the cerebral neo-and allocortex. As some of the clinical symptoms (eg, oculomotor dysfunctions) suggested a degeneration of select brainstem nuclei, we performed a systematic investigation of the brainstem of eight clinically diagnosed and genetically confirmed HD patients. This post-mortem investigation revealed a consistent neuronal loss in the substantia nigra, pontine nuclei, reticulotegmental nucleus of the pons, superior and inferior olives, in the area of the excitatory burst neurons for horizontal saccades, raphe interpositus nucleus and vestibular nuclei. Immunoreactive intranuclear neuronal inclusions were present in all degenerated and apparently spared brainstem nuclei and immunoreactive axonal inclusions were observed in all brainstem fiber tracts of the HD patients. Degeneration of brainstem nuclei can account for a number of less well-understood clinical HD symptoms (ie, cerebellar, oculomotor and vestibular symptoms), while the formation of axonal aggregates may represent a crucial event in the cascades of pathological events leading to neurodegeneration in HD. PMID:24779419

  19. Genetics Home Reference: inclusion body myopathy 2

    MedlinePlus

    ... Conditions inclusion body myopathy 2 inclusion body myopathy 2 Enable Javascript to view the expand/collapse boxes. ... Open All Close All Description Inclusion body myopathy 2 is a condition that primarily affects skeletal muscles , ...

  20. Lead poisoning in a sample of Maryland mourning doves

    USGS Publications Warehouse

    Locke, L.N.; Bagley, G.E.

    1967-01-01

    A sick mourning dove (Zenuidura macroura) collected in Maryland with 2 lead shot in the gizzard showed acid-fast intranuclear inclusion bodies in the kidney tubular cells. The liver and the tibia contained 72 ppm and 187 ppm lead (wet weight) respectively. Four gizzards from 62 doves killed by hunters contained lead shot. The lead content of 43 dove livers ranged from 0.4-14.0 ppm (wet weight); 40 of these doves were collected by hunters, and the other 3 were dying of trichomoniasis.

  1. Histopathology of mallards dosed with lead and selected substitute shot

    USGS Publications Warehouse

    Locke, L.N.; Irby, H.D.; Bagley, G.E.

    1967-01-01

    The histopathological response of male game farm mallards fed lead, three types of plastic-coated lead, two lead-magnesium alloys, iron, copper, zinc-coated iron, and molybdenum-coated iron shot was studied. Mallards fed lead, plastic-coated lead, or lead-magnesium alloy shot developed a similar pathological response, including the formation of acid-fast intranuclear inclusion bodies in the kidneys. Birds fed iron or molybdenum-coated iron shot developed hemosiderosis of the liver. Two of four mallards fed zinc-coated iron shot also developed hemosiderosis of the liver. No lesions were found in mallards fed copper shot.

  2. Innovation for an Inclusive Future

    NASA Astrophysics Data System (ADS)

    Springett, Mark; Rice, Mark; Carmichael, Alex; Griffiths, Richard

    This workshop will focus on setting the agenda for research, practice and policy in support of inclusive design for third generation computer-based products. The next generation of technology represents an unprecedented opportunity to improve the quality of life for groups of users who have previously faced exclusion, such as those with impairments and older citizens. At the same time it risks creating a greater digital divide and further exclusion. How we approach design for this new generation will determine whether or not the third wave will provide positive advances towards an inclusive digital world. We therefore need to put forward both a rationale for inclusive design and provide pointers towards technical development and design practice in support of inclusion. It is our belief that there is not only a strong moral case for design for inclusion but also significant commercial incentive, which may be key to persuading influential players to focus on inclusion. Therefore one of our key objectives is to describe and promote the advantages of designing ‘in from the edges’ of the user population rather than designing for a notional ‘average’ user.

  3. Persistence of chicken anemia virus antigen and inclusions in spontaneous cases of Marek’s disease visceral lymphomas in broiler chickens at slaughterhouses

    PubMed Central

    AHMED, Mohamed Sabry; ONO, Hiroki; SASAKI, Jun; OCHIAI, Kenji; GORYO, Masanobu

    2016-01-01

    The chicken anemia virus (CAV) and Marek’s disease virus (MDV) infect chickens worldwide; a single or dual infection by these viruses has a great impact on poultry production. In the present study, we examined the existence of CAV antigen and its inclusions in Marek’s disease (MD) lymphomas in chickens in the slaughterhouses of Iwate prefecture, Japan. Forty-nine spleens and 13 livers with different degrees of nodular lesions were histopathologically examined at our laboratory. Grossly, the tested organs showed various sizes and anatomical architectures. Based on the cellular morphology and the infiltrative nature of the neoplastic lymphocytes, MD was confirmed in 76% (37/49) of the spleens and 92% (12/13) of the livers. The lesions of MD, according to the pattern of lymphocytic accumulation in the affected organs, were divided into multifocal, coalesced and diffuse. CAV intranuclear inclusion bodies were detected within the small and the large bizarre lymphocytes of the MD lymphomas in 2 livers and 9 spleens, and the immunostaining test for CAV confirmed the persistence of CAV antigens and inclusions in the neoplastic cells. This study demonstrated the persistence of CAV infection within the neoplastic cells of naturally occurring MD lymphomas in chickens. PMID:26888585

  4. Persistence of chicken anemia virus antigen and inclusions in spontaneous cases of Marek's disease visceral lymphomas in broiler chickens at slaughterhouses.

    PubMed

    Ahmed, Mohamed Sabry; Ono, Hiroki; Sasaki, Jun; Ochiai, Kenji; Goryo, Masanobu

    2016-06-01

    The chicken anemia virus (CAV) and Marek's disease virus (MDV) infect chickens worldwide; a single or dual infection by these viruses has a great impact on poultry production. In the present study, we examined the existence of CAV antigen and its inclusions in Marek's disease (MD) lymphomas in chickens in the slaughterhouses of Iwate prefecture, Japan. Forty-nine spleens and 13 livers with different degrees of nodular lesions were histopathologically examined at our laboratory. Grossly, the tested organs showed various sizes and anatomical architectures. Based on the cellular morphology and the infiltrative nature of the neoplastic lymphocytes, MD was confirmed in 76% (37/49) of the spleens and 92% (12/13) of the livers. The lesions of MD, according to the pattern of lymphocytic accumulation in the affected organs, were divided into multifocal, coalesced and diffuse. CAV intranuclear inclusion bodies were detected within the small and the large bizarre lymphocytes of the MD lymphomas in 2 livers and 9 spleens, and the immunostaining test for CAV confirmed the persistence of CAV antigens and inclusions in the neoplastic cells. This study demonstrated the persistence of CAV infection within the neoplastic cells of naturally occurring MD lymphomas in chickens. PMID:26888585

  5. Renal pigmentation due to chronic bismuth administration in a rhesus macaque (Macaca mulatta).

    PubMed

    Johnson, A L; Blaine, E T; Lewis, A D

    2015-05-01

    Renal pigmentation due to the administration of exogenous compounds is an uncommon finding in most species. This report describes renal pigmentation and intranuclear inclusions of the proximal convoluted tubules due to chronic bismuth administration in a rhesus macaque. An 11-year-old Indian-origin rhesus macaque with a medical history of chronic intermittent vomiting had been treated with bismuth subsalicylate, famotidine, and omeprazole singly or in combination over the course of 8 years. At necropsy, the renal cortices were diffusely dark green to black. Light and electron microscopy revealed intranuclear inclusions within the majority of renal proximal tubular epithelial cells. These inclusions appeared magenta to brown when stained with hematoxylin and eosin and were negative by the Ziehl-Neelsen acid-fast stain. Elemental analysis performed on frozen kidney measured bismuth levels to be markedly elevated at 110.6 ppm, approximately 500 to 1000 times acceptable limits. To our knowledge, this is the first report of renal bismuth deposition in a rhesus macaque resulting in renal pigmentation and intranuclear inclusions. PMID:24990482

  6. Diverse Perspectives on Inclusive School Communities

    ERIC Educational Resources Information Center

    Tsokova, Diana; Tarr, Jane

    2012-01-01

    What is an inclusive school community? How do stakeholders perceive their roles and responsibilities towards inclusive school communities? How can school communities become more inclusive through engagement with individual perspectives? "Diverse Perspectives on Inclusive School Communities" captures and presents the voices of a wide range of…

  7. Interpreting Inclusivity: An Endeavour of Great Proportions

    ERIC Educational Resources Information Center

    Berlach, Richard George; Chambers, Dianne Joy

    2011-01-01

    Commencing with a historical account of how special needs education has informed the inclusivity debate, the authors consider the knotty problem of what is meant by inclusivity. An examination of the characteristics of inclusivity is then undertaken, and a functional school-based inclusivity framework--a three-faceted model--is proposed. The model…

  8. Special Teaching for Special Children? Pedagogies for Inclusion. Inclusive Education

    ERIC Educational Resources Information Center

    Lewis, Ann, Ed.; Norwich, Brahm, Ed.

    2004-01-01

    Some special needs groups (for example dyslexia) have argued strongly for the need for particular specialist approaches. In contrast, many proponents of inclusion have argued that "good teaching is good teaching for all" and that all children benefit from similar approaches. Both positions fail to scrutinise this issue rigorously and coherently,…

  9. The Inclusion of Music/the Music of Inclusion

    ERIC Educational Resources Information Center

    Lubet, Alex

    2009-01-01

    The intention of this paper is to situate music within inclusive education. Intersections of music--widely regarded as a "talent" or hyperability--and disability provide unique perspectives on social organisation in general and human valuation in particular. Music is a ubiquitous and an essential component of learning beginning in infancy.…

  10. Doing Research Inclusively: Bridges to Multiple Possibilities in Inclusive Research

    ERIC Educational Resources Information Center

    Nind, Melanie; Vinha, Hilra

    2014-01-01

    This article reports on a study of how people do research that matters to people with learning disabilities and that involves them and their views and experiences. The study was an attempt to bring together people doing inclusive research so that, collectively, we could take stock of our practices. This would add to the individual reports and…

  11. The Contours of Inclusion: Inclusive Arts Teaching and Learning

    ERIC Educational Resources Information Center

    Glass, Don; Henderson, Bill; Barnum, Leah; Kronenberg, Deborah; Blair, Kati; Jenkins, Richard; Hurel, Nicole Agois

    2010-01-01

    The purpose of this publication is to share models and case examples of the process of inclusive arts curriculum design and evaluation. The first section explains the conceptual and curriculum frameworks that were used in the analysis and generation of the featured case studies (i.e. Understanding by Design, Differentiated Instruction, and…

  12. The Needs of Inclusive Preschool Teachers about Inclusive Practices

    ERIC Educational Resources Information Center

    Akalin, Selma; Demir, Seyda; Sucuoglu, Bülbin; Bakkaloglu, Hatice; Iscen, Fadime

    2014-01-01

    Problem Statement: Since the law related to the inclusion of children with special needs was passed, the number of children with special needs in preschool classrooms has increased each year. Preschool teachers face serious challenges when they teach children with diverse abilities in the same environment. Although most of them support the idea of…

  13. Developing Inclusive Practice in Scotland: The National Framework for Inclusion

    ERIC Educational Resources Information Center

    Barrett, Louise; Beaton, Mhairi; Head, George; McAuliffe, Lisa; Moscardini, Lio; Spratt, Jennifer; Sutherland, Margaret

    2015-01-01

    This paper reports on the collaborative development of a "National Framework for Inclusion" under the auspices of the Scottish Teacher Education Committee by a working party representing each of the Scottish Universities providing initial teacher education. Recent research, international legislation and Scottish education policy have…

  14. Towards understanding microvillus inclusion disease.

    PubMed

    Vogel, Georg F; Hess, Michael W; Pfaller, Kristian; Huber, Lukas A; Janecke, Andreas R; Müller, Thomas

    2016-12-01

    Microvillus inclusion disease (MVID) is characterised by onset of intractable life-threatening watery diarrhoea during infancy. Transmission electron microscopy demonstrates shortening or absence of apical microvilli, pathognomonic microvillus inclusions in mature enterocytes and subapical accumulation of periodic acid-Schiff-positive granules or vesicles confirming diagnosis. Mutations in MYO5B have been found to cause MVID. In two patients with MVID, whole-exome sequencing of DNA revealed homozygous truncating mutations in STX3. Mutations in these genes disrupt trafficking between apical cargo vesicles and the apical plasma membrane. Thus, disturbed delivery of certain brush border membrane proteins is a common defect in MVID. PMID:26830108

  15. Classroom Management in Inclusive Settings

    ERIC Educational Resources Information Center

    Soodak, Leslie C.

    2003-01-01

    The inclusion of children with disabilities in general education classes provides an opportunity for teachers to identify classroom management policies and practices that promote diversity and community. Community-building management strategies that facilitate friendships, collaboration, parent involvement, and address challenging behaviors in a…

  16. The Inclusive Education in Europe

    ERIC Educational Resources Information Center

    Manzano-García, Beatriz; Fernández, María Tomé

    2016-01-01

    One of the phenomena that is of most concern to educational policy in Europe is immigration due to the fact that this is the source of new educational needs. This research looks at how European educational legislation deals with this topic. For this intercultural values that make inclusive education will be evaluated, we will analyze intercultural…

  17. Managing Special and Inclusive Education

    ERIC Educational Resources Information Center

    Rayner, Steve G.

    2007-01-01

    This book is a guide to special and inclusive education and provides a comprehensive overview of this complex field. Author Stephen Rayner examines context, policy, and practice, and shows how to successfully navigate the managerial challenges involved, while contributing to the way forward through leadership in a diverse field. The author…

  18. Grasping the Promise of Inclusion.

    ERIC Educational Resources Information Center

    Rudd, Fern

    A teacher and mother of a child with mental retardation examined the history and current status of the inclusion movement. A review of the historical background considers the origins of special education, the Education for All Handicapped Children Act of 1975, major court cases, and requirements of the 1997 amendments to the Individuals with…

  19. Inclusion in the Microsoft Workforce

    ERIC Educational Resources Information Center

    Exceptional Parent, 2008

    2008-01-01

    Since 1975, Microsoft has been a worldwide leader in software, services, and solutions that help people and businesses realize their full potential. Loren Mikola, the Disability Inclusion Program Manager at Microsoft, ensures that this technology also reaches and includes the special needs population and, through the hiring of individuals with…

  20. Early Childhood Inclusion in Croatia

    ERIC Educational Resources Information Center

    Ljubešic, Marta; Šimleša, Sanja

    2016-01-01

    This article explains early childhood inclusion in Croatia from its beginnings up to challenges in current policy and practice. The first preschool education for children with disabilities dates back to the 1980s and was provided in special institutions. In the last 10 years, mainstream kindergartens have been enrolling children with disabilities…

  1. Supporting General Educators' Inclusive Practices.

    ERIC Educational Resources Information Center

    Coombs-Richardson, Rita; Mead, Jean

    2001-01-01

    This article describes Project Inclusion, a state-funded project at Southeastern Louisiana University, which provided financial support for general educators to take university courses to develop their knowledge and skills concerning students with disabilities. The courses emphasized collaboration techniques, curricular modifications, and behavior…

  2. Taking Inclusion into the Future.

    ERIC Educational Resources Information Center

    Lipsky, Dorothy Kerzner; Gartner, Alan

    1998-01-01

    According to the reauthorized Individuals with Disabilities Education Act (1997), education of disabled children should produce outcomes akin to those expected of "regular" students, and disabled students should be educated with other kids. Implementing inclusive programs will require visionary leadership, educator collaboration, refocused…

  3. Tracing Inclusion: Determining Teacher Attitudes

    ERIC Educational Resources Information Center

    Logan, Brenda E.; Wimer, Gregory

    2013-01-01

    Though there appears to be an onslaught of No Child Left Behind, there is still more emphasis on testing than ever before. With the new implementation of national common-core standards, many school districts have moved towards full inclusive classrooms. However, it is rare that teachers have any input on whether such major decisions are apropos…

  4. Inclusive Education and the Arts

    ERIC Educational Resources Information Center

    Allan, Julie

    2014-01-01

    This paper addresses the troubled, problematic and contested field of inclusive education, characterised by antagonisms between so-called inclusionists and special educationists; frustration, particularly among disability activists caused by the abstraction of the social model of disability and the expansion of the special educational needs…

  5. Early Childhood Inclusion in Israel

    ERIC Educational Resources Information Center

    Al-Yagon, Michal; Aram, Dorit; Margalit, Malka

    2016-01-01

    This article describes conceptual aspects, current policies and practices, and research representing the Israeli perspective regarding early childhood inclusion (ECI) at preschool ages (3-6 years). We review legislative, historical, attitudinal, philosophical, practical, empirical, and cultural issues regarding ECI in Israel. Finally, we focus on…

  6. Curriculum Adaptation for Inclusive Classrooms.

    ERIC Educational Resources Information Center

    Neary, Tom; And Others

    This manual on curriculum adaptation for inclusive classrooms was developed as part of the PEERS (Providing Education for Everyone in Regular Schools) Project, a 5-year collaborative systems change project in California to facilitate the integration of students with severe disabilities previously at special centers into services at regular school…

  7. Towards Inclusion: An Australian Perspective

    ERIC Educational Resources Information Center

    Forbes, Fiona

    2007-01-01

    This article outlines the views of the Australian Special Education Principals' Association (ASEPA) on inclusion and the impact this is having on Australian Government Schools from a school based perspective. ASEPA is a relatively young association and was formed in 1997 out of the need to put forward the case to support students with special…

  8. Inclusive Education: Programmes and Provisions

    ERIC Educational Resources Information Center

    Kappen, Mini Dejo

    2010-01-01

    Inclusive education is a practice of teaching handicapped children in regular classrooms with non-handicapped children to the fullest extent possible; such children may have orthopedic, intellectual, emotional, or visual difficulties or handicaps associated with hearing or learning. In India there are constitutional provisions for Inclusive…

  9. Developing Movement as Inclusive Pedagogy

    ERIC Educational Resources Information Center

    Peter, Melanie; Walter, Ofra

    2010-01-01

    This article details the emergence of a training framework to support professional development in inclusive Movement teaching. This arose from a collaborative research project in spring 2008 (supported by the Training and Development Agency, UK), between two universities in England and Israel. Movement education is surprisingly underused globally,…

  10. Early Childhood Inclusion in Australia

    ERIC Educational Resources Information Center

    Kemp, Coral R.

    2016-01-01

    From the introduction of early intervention services in Australian in the mid-1970s, the families of children with intellectual and multiple disabilities have been encouraged to enroll their children in local preschools and childcare centers. Children with disabilities have also accessed a range of alternatives to full inclusion, such as reverse…

  11. Primordial Compositions of Refractory Inclusions

    SciTech Connect

    Grossman, L; Simon, S B; Rai, V K; Thiemens, M H; Hutcheon, I D; Williams, R W; Galy, A; Ding, T; Fedkin, A V; Clayton, R N; Mayeda, T K

    2008-02-20

    Bulk chemical and oxygen, magnesium and silicon isotopic compositions were measured for each of 17 Types A and B refractory inclusions from CV3 chondrites. After bulk chemical compositions were corrected for non-representative sampling in the laboratory, the Mg and Si isotopic compositions of each inclusion were used to calculate its original chemical composition assuming that the heavy-isotope enrichments of these elements are due to Rayleigh fractionation that accompanied their evaporation from CMAS liquids. The resulting pre-evaporation chemical compositions are consistent with those predicted by equilibrium thermodynamic calculations for high-temperature nebular condensates but only if different inclusions condensed from nebular regions that ranged in total pressure from 10{sup -6} to 10{sup -1} bar, regardless of whether they formed in a system of solar composition or in one enriched in OC dust relative to gas by a factor of ten relative to solar composition. This is similar to the range of total pressures predicted by dynamic models of the solar nebula for regions whose temperatures are in the range of silicate condensation temperatures. Alternatively, if departure from equilibrium condensation and/or non-representative sampling of condensates in the nebula occurred, the inferred range of total pressure could be smaller. Simple kinetic modeling of evaporation successfully reproduces observed chemical compositions of most inclusions from their inferred pre-evaporation compositions, suggesting that closed-system isotopic exchange processes did not have a significant effect on their isotopic compositions. Comparison of pre-evaporation compositions with observed ones indicates that 80% of the enrichment in refractory CaO + Al{sub 2}O{sub 3} relative to more volatile MgO + SiO{sub 2} is due to initial condensation and 20% due to subsequent evaporation for both Type A and Type B inclusions.

  12. PABPN1 overexpression leads to upregulation of genes encoding nuclear proteins that are sequestered in oculopharyngeal muscular dystrophy nuclear inclusions.

    PubMed

    Corbeil-Girard, Louis-Philippe; Klein, Arnaud F; Sasseville, A Marie-Josée; Lavoie, Hugo; Dicaire, Marie-Josée; Saint-Denis, Anik; Pagé, Martin; Duranceau, André; Codère, François; Bouchard, Jean-Pierre; Karpati, George; Rouleau, Guy A; Massie, Bernard; Langelier, Yves; Brais, Bernard

    2005-04-01

    Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset disease caused by expanded (GCN)12-17 stretches encoding the N-terminal polyalanine domain of the poly(A) binding protein nuclear 1 (PABPN1). OPMD is characterized by intranuclear inclusions (INIs) in skeletal muscle fibers, which contain PABPN1, molecular chaperones, ubiquitin, proteasome subunits, and poly(A)-mRNA. We describe an adenoviral model of PABPN1 expression that produces INIs in most cells. Microarray analysis revealed that PABPN1 overexpression reproducibly changed the expression of 202 genes. Sixty percent of upregulated genes encode nuclear proteins, including many RNA and DNA binding proteins. Immunofluorescence microscopy revealed that all tested nuclear proteins encoded by eight upregulated genes colocalize with PABPN1 within the INIs: CUGBP1, SFRS3, FKBP1A, HMG2, HNRPA1, PRC1, S100P, and HSP70. In addition, CUGBP1, SFRS3, and FKBP1A were also found in OPMD muscle INIs. This study demonstrates that a large number of nuclear proteins are sequestered in OPMD INIs, which may compromise cellular function. PMID:15755682

  13. Huntington’s disease (HD): Degeneration of select nuclei and widespread occurrence of neuronal nuclear and axonal inclusions in the brainstem

    PubMed Central

    Rüb, U; Hentschel, M; Stratmann, K; Brunt, ER; Heinsen, H; Seidel, K; Bouzrou, M; Auburger, G; Paulson, HL; Vonsattel, JP; Lange, HW; Korf, HW; den Dunnen, WF

    2014-01-01

    Huntington’s disease (HD) is a progressive polyglutamine disease that leads to a severe striatal and layer-specific neuronal loss in the cerebral neo-and allocortex. Since some of the clinical symptoms (e.g. oculomotor dysfunctions) suggested a degeneration of select brainstem nuclei we performed a systematic investigation of the brainstem of eight clinically diagnosed and genetically confirmed HD patients. This postmortem investigation revealed a consistent neuronal loss in the substantia nigra, pontine nuclei, reticulotegmental nucleus of the pons, superior and inferior olives, in the area of the excitatory burst neurons for horizontal saccades, raphe interpositus nucleus, and vestibular nuclei. Immunoreactive intranuclear neuronal inclusions were present in all degenerated and apparently spared brainstem nuclei, and immunoreactive axonal inclusions were observed in all brainstem fiber tracts of the HD patients. Degeneration of brainstem nuclei can account for a number of less well understood clinical HD symptoms (i.e. cerebellar, oculomotor and vestibular symptoms), while the formation of axonal aggregates may represent a crucial event in the cascades of pathological events leading to neurodegeneration in HD. PMID:24779419

  14. New approach to description of (d,xn) spectra at energies below 50 MeV in Monte Carlo simulation by intra-nuclear cascade code with Distorted Wave Born Approximation

    NASA Astrophysics Data System (ADS)

    Hashimoto, S.; Iwamoto, Y.; Sato, T.; Niita, K.; Boudard, A.; Cugnon, J.; David, J.-C.; Leray, S.; Mancusi, D.

    2014-08-01

    A new approach to describing neutron spectra of deuteron-induced reactions in the Monte Carlo simulation for particle transport has been developed by combining the Intra-Nuclear Cascade of Liège (INCL) and the Distorted Wave Born Approximation (DWBA) calculation. We incorporated this combined method into the Particle and Heavy Ion Transport code System (PHITS) and applied it to estimate (d,xn) spectra on natLi, 9Be, and natC targets at incident energies ranging from 10 to 40 MeV. Double differential cross sections obtained by INCL and DWBA successfully reproduced broad peaks and discrete peaks, respectively, at the same energies as those observed in experimental data. Furthermore, an excellent agreement was observed between experimental data and PHITS-derived results using the combined method in thick target neutron yields over a wide range of neutron emission angles in the reactions. We also applied the new method to estimate (d,xp) spectra in the reactions, and discussed the validity for the proton emission spectra.

  15. Women in Astronomy: Inclusion in Introductory Textbooks.

    ERIC Educational Resources Information Center

    Larsen, Kristine M.

    1995-01-01

    Discusses the reasons for identifying the contributions of women astronomers in introductory textbooks. The evolution of inclusion over the past 4 decades is explored by examining the rates of inclusion of 10 women astronomers in textbooks. Contains 100 references. (DDR)

  16. Forging Inclusive Solutions: Experiential Earth Charter Education

    ERIC Educational Resources Information Center

    Hill, Linda D.

    2010-01-01

    Forging Inclusive Solutions describes the aims, methodology and outcomes of Inclusive Leadership Adventures, an experiential education curriculum for exploring the Earth Charter. Experiential education builds meaningful relationships, skills, awareness and an inclusive community based on the Earth Charter principles. When we meet people where they…

  17. Deconstructing Normalisation: Clearing the Way for Inclusion.

    ERIC Educational Resources Information Center

    Culham, Andrew; Nind, Melanie

    2003-01-01

    This paper considers two major movements affecting the lives of people with intellectual disabilities: normalization and inclusion. It reviews the aims, processes, and outcomes of the normalization and social role valorization movement and explores its compatibility with inclusion. Lessons from normalization are applied to the inclusion movement.…

  18. "Inclusion in Practice": Does Practice Make Perfect?

    ERIC Educational Resources Information Center

    Slee, Roger

    2001-01-01

    Discusses four issues raised in this special issue: (1) problems with the term "inclusion"; (2) reductionist approaches to inclusive education; (3) politics of special education research and the need to include parent and student voices; and (4) preparation of teachers for inclusive education. (Contains 53 references.) (SK)

  19. Toward an Interdisciplinary Framework for Educational Inclusivity

    ERIC Educational Resources Information Center

    DeLuca, Christopher

    2013-01-01

    This purpose of this paper is to provide a theoretical foundation for inclusion in Canadian schools for this Special Issue on Inclusive Education. In response to the need for an interdisciplinary framework, this paper uses an interpretive literature review methodology to construct a framework for educational inclusivity based on four disciplinary…

  20. Louisiana High School Principals' Attitudes toward Inclusion

    ERIC Educational Resources Information Center

    Lorio, Katherine Matranga

    2011-01-01

    Principals' attitudes toward inclusion have been shown to have a positive impact on successful inclusive practices within schools. Providing guidance, support, and training to assist the faculty and staff with inclusion had been acknowledged to make a difference for schools administrators who were making changes to include more students with…

  1. Feature Issue on Inclusion and School Restructuring.

    ERIC Educational Resources Information Center

    Vandercook, Terri; York-Barr, Jennifer

    1996-01-01

    This feature issue on inclusion and school restructuring for students with and without disabilities contains the following articles: (1) "The 7 Habits for Educators" (Terri Vandercook); (2) "The Evolution of Inclusive Education" (Jennifer York-Barr and Terri Vandercook); (3) "Creating Inclusive Schools: What Does the Research Say?" (Margaret J.…

  2. Inclusive Education: Examining Equity on Five Continents

    ERIC Educational Resources Information Center

    Artiles, Alfredo J., Ed.; Kozleski, Elizabeth B., Ed.; Waitoller, Federico R., Ed.

    2011-01-01

    Despite the impressive growth of inclusive education around the world, questions and considerations about equity have been neglected. This edited volume makes a major contribution to the field of inclusive education by analyzing equity concerns that have emerged from the implementation of inclusive education models in nine nations on five…

  3. Measuring Inclusive Education Outcomes in Alberta, Canada

    ERIC Educational Resources Information Center

    Loreman, Tim

    2014-01-01

    This study details the results of a review of the academic and public sector literature on measuring inclusive education in large systems. It highlights some outcomes drawn from the international literature on inclusion that might be indicative of the presence and quality of inclusive education in an effort to develop a set of outcomes for…

  4. Ingredients for Inclusion: Lessons from the Literature

    ERIC Educational Resources Information Center

    McMaster, Christopher

    2012-01-01

    This paper explores features of successful inclusion through examples found in the literature. Schools have been given the imperative to become more inclusive through various government pronouncements and initiatives, but guidance in achieving that goal has been arguably wanting. School communities that have demonstrated more inclusive practice…

  5. Teachers' Experience with Inclusive Education in Singapore

    ERIC Educational Resources Information Center

    Yeo, Lay See; Chong, Wan Har; Neihart, Maureen F.; Huan, Vivien S.

    2016-01-01

    Teachers' positive attitude is most critically and consistently associated with successful inclusion. However, little is known about teachers' first-hand encounters with inclusive education in Singapore. We present findings from a qualitative study on inclusion based on focus group interviews with 202 teachers from 41 resourced primary schools.…

  6. Inclusive Attitudes: A Pre-Service Analysis

    ERIC Educational Resources Information Center

    Ryan, Thomas G.

    2009-01-01

    This enquiry has shown that pre-service teachers in Ontario, Canada (n = 141), believe they have the prerequisite training and knowledge to be inclusive educators. They believe inclusion is effective and produces required results for both identified and non-identified students. Inclusion was viewed as a difficult proposition dependent upon several…

  7. Elements of Inclusion: Findings from the Field

    ERIC Educational Resources Information Center

    McMaster, Christopher

    2014-01-01

    The Ministry of Education has set the target of 100% of New Zealand schools to be "mostly" inclusive by 2014. But what are the essential elements of inclusion? This paper explores essential core elements that allow inclusion to flourish. Based on an extensive time in the field as part of a year-long doctoral research project, these…

  8. Inclusion: By Choice or by Chance?

    ERIC Educational Resources Information Center

    Armstrong, Derrick; Armstrong, Ann Cheryl; Spandagou, Ilektra

    2011-01-01

    This paper explores the development internationally of the inclusive education perspective. Inclusive education as a late modernity reform project is exemplified in the call for "Education for All". Despite the simplicity of its message, inclusion is highly contestable. We argue in this paper that the key questions raised by the concept of…

  9. Questioning Secondary Inclusive Education: Are Inclusive Classrooms Always Best for Students?

    ERIC Educational Resources Information Center

    Tkachyk, Ruth Elizabeth

    2013-01-01

    Educating students with special needs in inclusive settings has become a priority for westernized governments as they strive to create more inclusive societies. While recognizing the societal benefits of inclusion, teachers and parents question whether or not implementation of full inclusion will come at the expense of learners' individual…

  10. Measuring Quality in Inclusive Preschool Classrooms: Development and Validation of the Inclusive Classroom Profile (ICP)

    ERIC Educational Resources Information Center

    Soukakou, Elena P.

    2012-01-01

    The purpose of this study was to develop and validate an observation measure designed to assess classroom quality in inclusive preschool programs, the Inclusive Classroom Profile (ICP). Developing the rating scale entailed systematic fieldwork in inclusive settings and review of the literature on preschool inclusion. Results from the validation…

  11. Melt inclusions in Luna 24 soil fragments

    NASA Technical Reports Server (NTRS)

    Roedder, W.; Weiblen, P. W.

    1978-01-01

    Optical examinations of 28 slides of Luna 24 soil fragments revealed melt inclusions in grains of olivine, plagioclase, spinel, and ilmenite as well as interstitial inclusions. In contrast with Apollo samples, the Luna 24 samples contain sulfide melt inclusions, which indicates that saturation with respect to an iron sulfide melt took place throughout much of the crystallization history, even while olivine was crystallizing. The Luna 24 silicate-melt inclusions have recorded a more extensive differentiation toward higher iron magmas than have the Apollo inclusions, but they have also recorded some inexplicably low aluminum values.

  12. Antiferromagnetic inclusions in lunar glass

    USGS Publications Warehouse

    Thorpe, A.N.; Senftle, F.E.; Briggs, Charles; Alexander, Corrine

    1974-01-01

    The magnetic susceptibility of 11 glass spherules from the Apollo 15, 16, and 17 fines and two specimens of a relatively large glass spherical shell were studied as a function of temperature from room temperature to liquid helium temperatures. All but one specimen showed the presence of antiferromagnetic inclusions. Closely spaced temperature measurements of the magnetic susceptibility below 77 K on five of the specimens showed antiferromagnetic temperature transitions (Ne??el transitions). With the exception of ilmenite in one specimen, these transitions did not correspond to any transitions in known antiferromagnetic compounds. ?? 1974.

  13. Transverse SSA in inclusive DIS

    NASA Astrophysics Data System (ADS)

    Pitonyak, Daniel

    2013-10-01

    We analyze the transverse single spin asymmetry (SSA) in inclusive deep inelastic scattering (DIS), which requires a two-photon exchange to generate a non-zero effect. We present numerical results for the SSA that allow us to comment on the so-called "sign mismatch" issue invloving the Efremov-Teryaev-Qiu-Sterman (ETQS) function TF(x,x). In particular, we discuss how our results indicate a collinear twist-3 Sivers-type effect may not be the main cause of the SSAs seen in proton-proton (pp) collisions.

  14. Inclusive fitness theory and eusociality.

    PubMed

    Abbot, Patrick; Abe, Jun; Alcock, John; Alizon, Samuel; Alpedrinha, Joao A C; Andersson, Malte; Andre, Jean-Baptiste; van Baalen, Minus; Balloux, Francois; Balshine, Sigal; Barton, Nick; Beukeboom, Leo W; Biernaskie, Jay M; Bilde, Trine; Borgia, Gerald; Breed, Michael; Brown, Sam; Bshary, Redouan; Buckling, Angus; Burley, Nancy T; Burton-Chellew, Max N; Cant, Michael A; Chapuisat, Michel; Charnov, Eric L; Clutton-Brock, Tim; Cockburn, Andrew; Cole, Blaine J; Colegrave, Nick; Cosmides, Leda; Couzin, Iain D; Coyne, Jerry A; Creel, Scott; Crespi, Bernard; Curry, Robert L; Dall, Sasha R X; Day, Troy; Dickinson, Janis L; Dugatkin, Lee Alan; El Mouden, Claire; Emlen, Stephen T; Evans, Jay; Ferriere, Regis; Field, Jeremy; Foitzik, Susanne; Foster, Kevin; Foster, William A; Fox, Charles W; Gadau, Juergen; Gandon, Sylvain; Gardner, Andy; Gardner, Michael G; Getty, Thomas; Goodisman, Michael A D; Grafen, Alan; Grosberg, Rick; Grozinger, Christina M; Gouyon, Pierre-Henri; Gwynne, Darryl; Harvey, Paul H; Hatchwell, Ben J; Heinze, Jürgen; Helantera, Heikki; Helms, Ken R; Hill, Kim; Jiricny, Natalie; Johnstone, Rufus A; Kacelnik, Alex; Kiers, E Toby; Kokko, Hanna; Komdeur, Jan; Korb, Judith; Kronauer, Daniel; Kümmerli, Rolf; Lehmann, Laurent; Linksvayer, Timothy A; Lion, Sébastien; Lyon, Bruce; Marshall, James A R; McElreath, Richard; Michalakis, Yannis; Michod, Richard E; Mock, Douglas; Monnin, Thibaud; Montgomerie, Robert; Moore, Allen J; Mueller, Ulrich G; Noë, Ronald; Okasha, Samir; Pamilo, Pekka; Parker, Geoff A; Pedersen, Jes S; Pen, Ido; Pfennig, David; Queller, David C; Rankin, Daniel J; Reece, Sarah E; Reeve, Hudson K; Reuter, Max; Roberts, Gilbert; Robson, Simon K A; Roze, Denis; Rousset, Francois; Rueppell, Olav; Sachs, Joel L; Santorelli, Lorenzo; Schmid-Hempel, Paul; Schwarz, Michael P; Scott-Phillips, Tom; Shellmann-Sherman, Janet; Sherman, Paul W; Shuker, David M; Smith, Jeff; Spagna, Joseph C; Strassmann, Beverly; Suarez, Andrew V; Sundström, Liselotte; Taborsky, Michael; Taylor, Peter; Thompson, Graham; Tooby, John; Tsutsui, Neil D; Tsuji, Kazuki; Turillazzi, Stefano; Ubeda, Francisco; Vargo, Edward L; Voelkl, Bernard; Wenseleers, Tom; West, Stuart A; West-Eberhard, Mary Jane; Westneat, David F; Wiernasz, Diane C; Wild, Geoff; Wrangham, Richard; Young, Andrew J; Zeh, David W; Zeh, Jeanne A; Zink, Andrew

    2011-03-24

    Arising from M. A. Nowak, C. E. Tarnita & E. O. Wilson 466, 1057-1062 (2010); Nowak et al. reply. Nowak et al. argue that inclusive fitness theory has been of little value in explaining the natural world, and that it has led to negligible progress in explaining the evolution of eusociality. However, we believe that their arguments are based upon a misunderstanding of evolutionary theory and a misrepresentation of the empirical literature. We will focus our comments on three general issues. PMID:21430721

  15. Semi-inclusive DIS: Factorization

    SciTech Connect

    Yuan, Feng

    2008-12-10

    In this talk, we will present a QCD factorization theorem for the semi-inclusive deep-inelastic scattering with hadrons in the current fragmentation region detected at low transverse momentum. There has been considerable experimental and theoretical interest in semi-inclusive hadron production in deep inelastic scattering (SIDIS) processes. For example, by studying the polarized and unpolarized SIDIS, one will be able to identify the sea quark distribution and polarization in nucleon, and the experimental results from the HERMES collaboration have revealed nontrivial sea structure in nucleon [1]. More recently, SIDIS opened a new window to study the transverse momentum dependent (TMD) parton distributions and fragmentation functions from the low transverse momentum hadron production. The transverse momentum distribution of the final state hadron is directly related to the transverse momentum dependence of the parton distributions and fragmentation. These studies will provide new opportunities to explore the partonic structure of nucleon, especially the three-dimension distribution of partons inside nucleon. The DIS experiments, including HERMES, COMPAS, and JLab Hall B collaborations, have studied various azimuthal asymmetries in SIDIS. In particular, the HERMES collaboration found sizable single spin asymmetries in these processes involving nontrivial QCD effects and hadron structure.

  16. The crack-inclusion interaction problem

    NASA Technical Reports Server (NTRS)

    Liu, X.-H.; Erdogan, F.

    1986-01-01

    The general plane elastostatic problem of interaction between a crack and an inclusion is considered. The Green's functions for a pair of dislocations and a pair of concentrated body forces are used to generate the crack and the inclusion. Integral equations are obtained for a line crack and an elastic line inclusion having an arbitrary relative orientation and size. The nature of stress singularity around the end points of rigid and elastic inclusions is described and three special cases of this intersection problem are studied. The problem is solved for an arbitrary uniform stress state away from the crack-inclusion region. The nonintersecting crack-inclusion problem is considered for various relative size, orientation, and stiffness parameters, and the stress intensity factors at the ends of the inclusion and the crack are calculated. For the crack-inclusion intersection case, special stress intensity factors are defined and are calculated for various values of the parameters defining the relative size and orientation of the crack and the inclusion and the stiffness of the inclusion.

  17. The crack-inclusion interaction problem

    NASA Technical Reports Server (NTRS)

    Xue-Hui, L.; Erdogan, F.

    1984-01-01

    The general plane elastostatic problem of interaction between a crack and an inclusion is considered. The Green's functions for a pair of dislocations and a pair of concentrated body forces are used to generate the crack and the inclusion. Integral equations are obtained for a line crack and an elastic line inclusion having an arbitrary relative orientation and size. The nature of stress singularity around the end points of rigid and elastic inclusions is described and three special cases of this intersection problem are studied. The problem is solved for an arbitrary uniform stress state away from the crack-inclusion region. The nonintersecting crack-inclusion problem is considered for various relative size, orientation, and stiffness parameters, and the stress intensity factors at the ends of the inclusion and the crack are calculated. For the crack-inclusion intersection case, special stress intensity factors are defined and are calculated for various values of the parameters defining the relative size and orientation of the crack and the inclusion and the stiffness of the inclusion.

  18. Shock Re-equilibration of Fluid Inclusions

    NASA Technical Reports Server (NTRS)

    Madden, M. E. Elwood; Horz, F.; Bodnar, R. J.

    2004-01-01

    Fluid inclusions (microscopic volumes of fluid trapped within minerals as they precipitate) are extremely common in terrestrial minerals formed under a wide range of geological conditions from surface evaporite deposits to kimberlite pipes. While fluid inclusions in terrestrial rocks are nearly ubiquitous, only a few fluid inclusion-bearing meteorites have been documented. The scarcity of fluid inclusions in meteoritic materials may be a result of (a) the absence of fluids when the mineral was formed on the meteorite parent body or (b) the destruction of fluid inclusions originally contained in meteoritic materials by subsequent shock metamorphism. However, the effects of impact events on pre-existing fluid inclusions trapped in target and projectile rocks has received little study. Fluid inclusions trapped prior to the shock event may be altered (re-equilibrated) or destroyed due to the high pressures, temperatures, and strain rates associated with impact events. By examining the effects of shock deformation on fluid inclusion properties and textures we may be able to better constrain the pressure-temperature path experienced by terrestrial and meteoritic shocked materials and also gain a clearer understanding of why fluid inclusions are rarely found in meteorite samples.

  19. Making the case for inclusive design.

    PubMed

    Waller, Sam; Bradley, Mike; Hosking, Ian; Clarkson, P John

    2015-01-01

    This paper describes the University of Cambridge, Engineering Design Centre's (EDC) case for inclusive design, based on 10 years of research, promotion and knowledge transfer. In summary, inclusive design applies an understanding of customer diversity to inform decisions throughout the development process, in order to better satisfy the needs of more people. Products that are more inclusive can reach a wider market, improve customer satisfaction and drive business success. The rapidly ageing population increases the importance of this approach. The case presented here has helped to convince BT, Nestlé and others to adopt an inclusive approach. PMID:23538129

  20. Supporting Students with Severe Disabilities in Inclusive Schools: A Descriptive Account From Schools Implementing Inclusive Practices

    ERIC Educational Resources Information Center

    Kurth, Jennifer A.; Lyon, Kristin J.; Shogren, Karrie A.

    2015-01-01

    The purpose of the present study was to investigate practices that support the inclusion of students with severe disabilities in the learning and social activities of inclusive K-8 schools to inform inclusive school reform research and practice. Eighteen K-8 students with severe disabilities in six schools recognized for their implementation of…

  1. Full Inclusion: The Benefits and Disadvantages of Inclusive Schooling. An Overview

    ERIC Educational Resources Information Center

    McCarty, Kristine

    2006-01-01

    An overview of debated issues related to the benefits and disadvantages of inclusive schooling. The beliefs of districts, school personnel and parents are widely differing as related to the placement of students with special needs in inclusive settings. The examples of current federal laws help to shape the debate of full inclusion in schools…

  2. More Policies, Greater Inclusion? Exploring the Contradictions of New Labour Inclusive Education Policy

    ERIC Educational Resources Information Center

    Roulstone, Alan; Prideaux, Simon

    2008-01-01

    The era of New Labour government has witnessed unprecedented growth in inclusive education policies. There is, however, limited evidence that policies have increased disabled children's inclusion. This article explores reasons for this contradiction. Drawing on sociological insights, it is argued that New Labour policies on inclusive education…

  3. Measuring the Quality of Inclusive Practices: Findings from the Inclusive Classroom Profile Pilot

    ERIC Educational Resources Information Center

    Soukakou, Elena P.; Winton, Pam J.; West, Tracey A.; Sideris, John H.; Rucker, Lia M.

    2014-01-01

    The purpose of this study was to test the reliability and validity of the Inclusive Classroom Profile (ICP), an observation measure designed to assess the quality of classroom practices in inclusive preschool programs. The measure was field tested in 51 inclusive classrooms. Results confirmed and extended previous research findings, providing…

  4. What's Working: Topics in Inclusive Education.

    ERIC Educational Resources Information Center

    What's Working, 1994

    1994-01-01

    This newsletter focuses on what works in inclusive education. A major article is "Inclusive Education: Needs of Minnesota Families--Major Findings from a 'Together We're Better' Study." This article presents findings of a statewide survey of families of children with disabilities. Findings are categorized within four areas: (1) educational…

  5. How Does Supervision Support Inclusive Teacherhood?

    ERIC Educational Resources Information Center

    Alila, Sanna; Määttä, Kaarina; Uusiautti, Satu

    2016-01-01

    Supervision is a multidimensional concept and phenomenon. In this study, the advantages of supervision and its development in inclusive teacherhood was studied. Inclusive teacherhood means a teacher's professional development and the school culture's change toward participatory school for all students. The study analyzed the views of supervisors…

  6. Early Childhood Inclusion: Focus on Change.

    ERIC Educational Resources Information Center

    Guralnick, Michael J., Ed.

    Early childhood inclusion is a field characterized by a philosophy and practice that encourages full participation of children with disabilities and their families in everyday activities with their typically developing peers. Noting that success in inclusion endeavors requires substantial changes in the way our society thinks, feels, and acts,…

  7. Metaphors of Literacy: Dialogues in Inclusive Settings

    ERIC Educational Resources Information Center

    Causarano, Antonio

    2015-01-01

    This article discusses the importance of metaphors in education and in inclusive settings in particular. Metaphors are seen as the fabric of collaboration through dialogue across the curriculum. The article analyzes the dialogues among the Language Arts, Social Studies, and inclusion teacher in a large middle school in the Southwest of the United…

  8. Inclusive Focus Particles in English and Korean

    ERIC Educational Resources Information Center

    Kang, Sang-gu

    2011-01-01

    When discussing focus particles, it has been common practice to rely on the dichotomy of inclusive vs. exclusive particles, "a la" Konig (1991). Inclusive focus particles are often further divided into scalar particles, such as "also", "too", and "either", and non-scalar particles, such as "even". In this thesis, I advance a comparative analysis…

  9. Inclusive Education in Malaysia: Policy and Practice

    ERIC Educational Resources Information Center

    Jelas, Zalizan M.; Ali, Manisah Mohd

    2014-01-01

    Malaysia's move towards inclusion was given impetus by its participation in workshops and conferences set up under the auspices of the United Nations (UNESCO 1990; UN 1993; UNESCO 1994). Inclusive education was introduced in the Education Act 1996 as part of the continuum of services available for children with special needs. The purpose of…

  10. Inclusive Education: Teacher Perspectives from Malaysia

    ERIC Educational Resources Information Center

    Bailey, Lucy; Nomanbhoy, Alefiya; Tubpun, Tida

    2015-01-01

    This paper reports on a survey of views of inclusive education expressed by nearly 300 Malaysian primary school teachers involved in remedial literacy and numeracy education under the country's Literacy and Numeracy Strategy. Overall, the views expressed were positive towards the principle of inclusion. However, despite common professional…

  11. International Perspectives on Inclusion: Concluding Thoughts.

    ERIC Educational Resources Information Center

    Timmons, Vianne

    2002-01-01

    This article discusses overall trends and commonalities among previous articles on inclusion in the United Kingdom, Ireland, India, South Africa, Canada, New Zealand, and Australia. It concludes that inclusive education must be viewed in a broader context that looks at school reform and the societal context. Teacher education is stressed.…

  12. Social Inclusion and Critical Consciousness in Australia

    ERIC Educational Resources Information Center

    Diemer, Matthew A.; Ortega, Lilyana

    2010-01-01

    Australia's Indigenous population is excluded from a range of opportunities, experiences and amenities that facilitate wellbeing, self-determination and social inclusion. This social exclusion constrains the career development and occupational attainment of Indigenous youth, which represent key routes to societal inclusion. Critical…

  13. The Challenges of Inclusive Education in Lebanon

    ERIC Educational Resources Information Center

    Wehbi, Samantha

    2006-01-01

    This article reports on a study conducted in Lebanon by four non-governmental organizations, primarily on the topic of inclusion of people with disabilities in education, with a secondary focus on inclusion in employment. This article reports on some of the findings of the assessment process that was four months in duration and aimed, through…

  14. The Sustainability of Inclusive School Reform

    ERIC Educational Resources Information Center

    Sindelar, Paul T.; Shearer, Deirdre K.; Yendol-Hoppey, Diane; Liebert, Todd W.

    2006-01-01

    For over a decade, University of Florida researchers worked with middle schools in a large urban and suburban south Florida district, as they developed and then worked to sustain inclusive reform. One middle school, Socrates, was notably successful, having built its inclusion model on a foundation of previous reform and a school culture…

  15. Geometric Modeling of Inclusions as Ellipsoids

    NASA Technical Reports Server (NTRS)

    Bonacuse, Peter J.

    2008-01-01

    Nonmetallic inclusions in gas turbine disk alloys can have a significant detrimental impact on fatigue life. Because large inclusions that lead to anomalously low lives occur infrequently, probabilistic approaches can be utilized to avoid the excessively conservative assumption of lifing to a large inclusion in a high stress location. A prerequisite to modeling the impact of inclusions on the fatigue life distribution is a characterization of the inclusion occurrence rate and size distribution. To help facilitate this process, a geometric simulation of the inclusions was devised. To make the simulation problem tractable, the irregularly sized and shaped inclusions were modeled as arbitrarily oriented, three independent dimensioned, ellipsoids. Random orientation of the ellipsoid is accomplished through a series of three orthogonal rotations of axes. In this report, a set of mathematical models for the following parameters are described: the intercepted area of a randomly sectioned ellipsoid, the dimensions and orientation of the intercepted ellipse, the area of a randomly oriented sectioned ellipse, the depth and width of a randomly oriented sectioned ellipse, and the projected area of a randomly oriented ellipsoid. These parameters are necessary to determine an inclusion s potential to develop a propagating fatigue crack. Without these mathematical models, computationally expensive search algorithms would be required to compute these parameters.

  16. Culturally Inclusive Curriculum in Higher Education

    ERIC Educational Resources Information Center

    Pridham, Bruce; Martin, Dona; Walker, Kym; Rosengren, Rosie; Wadley, Danielle

    2015-01-01

    The Australian National Program Standards for Teacher Education prioritises knowledge of culturally inclusive practices and challenges the educational community to present research on well-structured, inclusive, cross-curricula education partnerships. This article meets this challenge as it explores a core unit of work for undergraduate teachers…

  17. Standards & Inclusion: Can We Have Both?. [Videotape].

    ERIC Educational Resources Information Center

    Lipsky, Dorothy Kerzner; Gartner, Alan

    Designed for regular and special educators, this 40-minute video profiles inclusive schools from around the country that have successfully incorporated academic standards. It addresses many of the critical issues facing educators who are supporting students with disabilities in inclusive settings. Topics discussed include: (1) the consequences of…

  18. A Collaborative Group Method of Inclusive Research

    ERIC Educational Resources Information Center

    Bigby, Christine; Frawley, Patsie; Ramcharan, Paul

    2014-01-01

    Background: Funding bodies in Australia and the United Kingdom require research on issues that affect the lives of people with intellectual disability to be inclusive. Debate continues about the nature and benefits of inclusive research, which has become an umbrella term encompassing a broad spectrum of approaches. Method: This study proposes one…

  19. Questions of Inclusion in Scotland and Europe

    ERIC Educational Resources Information Center

    Allan, Julie

    2010-01-01

    This paper examines inclusion in Scotland and in Europe. It considers some of the uncertainties surrounding inclusion and the questions--many of which give cause for concern--that are currently being raised by researchers, teachers and their representative unions, parents and children. The shifting political and policy contexts and recent patterns…

  20. Inclusive Education: A Series of Issue Papers.

    ERIC Educational Resources Information Center

    Illinois Coalition on School Inclusion, Springfield.

    Thirteen brief papers address issues in inclusive education, with special emphasis on concerns and applications in Illinois. The following issues are discussed: (1) the relationship of the inclusive schools concept to that of providing a continuum of alternative placement options; (2) needed changes in current funding of special education to…

  1. Inclusion: Something More Than Sitting Together

    ERIC Educational Resources Information Center

    Bulbul, Mustafa Sahin

    2011-01-01

    Awareness about students with learning difficulty brought us to inclusive learning environments. The acceptance was to build collaborative atmospheres in the class. Unfortunately, when teachers are not enthusiastic and adequate to develop the interaction, the inclusive learning environment never occurs. This conclusion bases on this studies…

  2. Classroom Groups: Inclusion of Students with Disabilities.

    ERIC Educational Resources Information Center

    Fields, Teesue H.

    1995-01-01

    Discusses the inclusion of students with disabilities in the regular classroom group. Analyzes the structure of the classroom group to determine its receptivity to students with disabilities. Presents special problems that might be encountered during inclusion and possibilities for improving classroom group skills. (LKS)

  3. Case Studies for Inclusive Schools. Second Edition

    ERIC Educational Resources Information Center

    Anderson, Peggy L.

    2005-01-01

    Case Studies for "Inclusive Schools, Second Edition" presents a sampling of case studies that contain realistic problems concerning inclusion issues for teacher education students to solve. This format was chosen because the case study approach to learning is gaining in popularity as it provides students with an opportunity to apply information…

  4. Design, Development and Implementation of Inclusive Education

    ERIC Educational Resources Information Center

    Mooij, Ton; Smeets, Ed

    2006-01-01

    In inclusive education different pupils, including pupils with special educational needs and high ability pupils, can be stimulated to learn according to their capacities and potentials. The research question concentrates on the design features of inclusive education that will optimally promote the motivation and learning processes and outcomes of…

  5. Erasmus Mundus SEN: The Inclusive Scholarship Programme?

    ERIC Educational Resources Information Center

    Grinbergs, Christopher J.; Jones, Hilary

    2013-01-01

    The Erasmus Mundus MA/Mgr in Special Education Needs (EM SEN) was created as a Masters Course funded by the European Commission's Erasmus Mundus Programme (EMP) to challenge and educate students in inclusive policy and practice in education. Yet, it is debatable the extent to which this programme embodies the values of an inclusive approach,…

  6. Tensions around Inclusion: Reframing the Moral Horizon

    ERIC Educational Resources Information Center

    Clegg, Jennifer; Murphy, Elizabeth; Almack, Kathryn; Harvey, Anna

    2008-01-01

    Background: Inclusion is one of four policies for people with disabilities in the UK. Criticisms of its three key attributes--mainstreaming, independent living and employment--are reviewed. Methods: This study of 28 young people, most with severe intellectual disabilities, investigated engagement with inclusion at their transition to adult…

  7. Inclusive Partnership: Enhancing Student Engagement in Geography

    ERIC Educational Resources Information Center

    Moore-Cherry, Niamh; Healey, Ruth; Nicholson, Dawn T.; Andrews, Will

    2016-01-01

    Partnership is currently the focus of much work within higher education and advocated as an important process to address a range of higher education goals. In this paper, we propose the term "inclusive partnership" to conceptualise a non-selective staff-student relationship. While recognising the challenges of inclusive partnership…

  8. Beyond Political Correctness: Toward the Inclusive University.

    ERIC Educational Resources Information Center

    Richer, Stephen, Ed.; Weir, Lorna, Ed.

    This collection of 12 essays examines the history of the discourse over political correctness (PC) in Canadian academia, focusing on the neoconservative backlash to affirmative action, inclusive policies, and feminist and anti-racist teaching in the classroom. It includes: (1) "Introduction: Political Correctness and the Inclusive University"…

  9. Inclusive Education: A Servant-Leadership Perspective

    ERIC Educational Resources Information Center

    Crippen, Carolyn

    2005-01-01

    The concept of inclusive education is common to the Canadian educational system and involves service to the students. According to Young and Levin, "The provision of appropriate education to meet the needs of each student is increasingly accepted as a right in Canadian education." Bloom, Perlmutter and Burnell define inclusion as "a philosophy…

  10. Older Women's Career Development and Social Inclusion

    ERIC Educational Resources Information Center

    McMahon, Mary; Bimrose, Jenny; Watson, Mark

    2010-01-01

    This paper considers women's career development and the potential contribution of career development theory, research, practice and policy in advancing a social inclusion agenda. In particular, the paper focuses on older women in the contexts of an ageing population, labour market shortages and Australia's social inclusion agenda. Supporting young…

  11. The Inclusive Secondary School Teacher in Australia

    ERIC Educational Resources Information Center

    Pearce, Michelle

    2009-01-01

    As a result of the 1992 Disability Discrimination Act in Australia and parental support for inclusion, regular teachers now include students with disabilities in their classes. Inclusion has been more successful in primary than in secondary schools. Secondary schools remain a challenge due to their traditional focus on curriculum, examinations,…

  12. Irish Mathematics Teachers' Attitudes towards Inclusion

    ERIC Educational Resources Information Center

    Whitty, Elaine; Clarke, Marie

    2012-01-01

    This paper through the theoretical framework of constructive attitude theory explores mathematics teachers' attitudes and pedagogical strategies with reference to inclusive practice. The authors argue that though teachers may have formed positive inclusive attitudes, the translation of these into practice does not always occur and poses…

  13. Diversity ? Inclusion: Promoting Integration in Higher Education

    ERIC Educational Resources Information Center

    Tienda, Marta

    2013-01-01

    I argue that enrollment of a diverse student body is but a pragmatic first step toward the broader social goal of inclusion and ask whether motives for campus diversification are aligned with pedagogic goals. I address this question by focusing on inclusion, namely, organizational strategies and practices that promote meaningful social and…

  14. Characteristics of Inclusive Classrooms in Turkey

    ERIC Educational Resources Information Center

    Melekoglu, Macid Ayhan

    2014-01-01

    In this paper, inclusive classrooms in Turkey are described in terms of the characteristics of both classroom teachers and students with special needs. Participants of this study consisted of 54 teachers working in inclusive classrooms and 54 students with mild intellectual disabilities in those classrooms in Turkey. Data for this study were…

  15. Enhancing Theory Courses with Racially Inclusive Research.

    ERIC Educational Resources Information Center

    Bramlett-Solomon, Sharon; Liebler, Carol M.

    1999-01-01

    Offers a blueprint that instructors of mass media theory courses can adopt to expose students to racially inclusive research in order to encourage students to explore and employ relevant theories when probing media and race questions. Offers examples of inclusive media research, examining six prominent theories: selective-perception theory,…

  16. Students' Perspectives on LGBTQ-Inclusive Curriculum

    ERIC Educational Resources Information Center

    Snapp, Shannon D.; Burdge, Hilary; Licona, Adela C.; Moody, Raymond L.; Russell, Stephen T.

    2015-01-01

    Implementing curriculum that is inclusive of lesbian, gay, bisexual, transgender, queer, and questioning (LGBTQ) people has the potential to create an equitable learning environment. In order to learn more about students' experiences of LGBTQ-inclusive curriculum, 26 high school students with diverse racial/ethnic, sexual, and gender identities…

  17. Moving Forward in Inclusive Education Research

    ERIC Educational Resources Information Center

    Erten, Ozlem; Savage, Robert Samuel

    2012-01-01

    This paper aims to address conceptual and methodological challenges of doing research in the field of inclusive education and revisit school effectiveness research literature to inform future research. First, we present the rationale for inclusive education and briefly review the evolution of special needs education. Then, we discuss limitations…

  18. Inclusive Education in Thailand: Practices and Challenges

    ERIC Educational Resources Information Center

    Vorapanya, Sermsap; Dunlap, Diane

    2014-01-01

    In 2008, Thailand passed legislation on the educational provisions for students with disabilities to mandate the implementation of inclusive education. This article provides a historical overview of special education in Thailand and the emergence of inclusive education as it moves from policy to practice. To further identify the challenges faced…

  19. Beyond Prejudice: Inclusive Learning in Practice

    ERIC Educational Resources Information Center

    Smith, Vikki; Armstrong, Anne

    2005-01-01

    Promoting an inclusive learning environment that caters for all learners and their individual needs and meeting challenging targets set in this area is a huge under taking for providers across the learning and skills sector. This booklet provides an overview that illustrates the breadth and variety that the broad banner of inclusive learning…

  20. Inclusive Schooling Policy: An Educational Detective Story?

    ERIC Educational Resources Information Center

    Moss, Julianne

    2003-01-01

    Since the publication of the Salamanca statement (UNESCO 1994), inclusive schooling has formed a growing part of the deliberations of the special education community. Inclusive schooling research in Australia in the main continues to reproduce traditions of the special education field, emphasising the dominant psychological perspectives that have…

  1. Inclusive Education: Is This Horse a Trojan?

    ERIC Educational Resources Information Center

    Slee, Roger

    2006-01-01

    In Canada and elsewhere, governments are expending considerable effort in the production of inclusive education policy texts, resources allocation models, and programs. The author notes that despite of the analytic power and the political intent of inclusive education as a counterpoint to special education, its appropriation is imminent if not…

  2. Secondary General Education Teachers' Attitudes toward Inclusion

    ERIC Educational Resources Information Center

    Wilson, Valerie A.

    2014-01-01

    Since the inception of the Individuals with Disabilities Education Improvement Act, educators have struggled with including students with disabilities in the general education classroom with their nondisabled peers. The inclusion educational model was utilized in this study to explore secondary teachers' attitudes toward inclusive educational…

  3. Striving for Quality in Early Childhood Inclusion

    ERIC Educational Resources Information Center

    Brancato, Kimberly

    2013-01-01

    An essential component of best practice in the field of early childhood special education is the inclusion of children with disabilities in typical early childhood settings. As the practice of inclusion has increased in recent years it has become imperative to ensure that children with disabilities attend quality programs. The main purpose of this…

  4. Teachers' Misunderstanding: The Concept of Inclusive Education

    ERIC Educational Resources Information Center

    Sanagi, Tomomi

    2016-01-01

    Teachers' misunderstanding the concept of inclusive education will not lead to good practices, rather make an exclusive environment for pupils with special educational needs in mainstream schools. This study clarified teachers' attitudes towards the image of inclusive education with conjoint analysis and cluster analysis. The participants for this…

  5. International Teachers' Attitudes towards Inclusion in Turkey

    ERIC Educational Resources Information Center

    Pursley, Lisa

    2014-01-01

    The inclusion of students with disabilities in the general education classroom has become a universally debated topic in education. More schools all over the world are seeking to use inclusion as their main service delivery model for students with disabilities. Much research has been conducted globally to gain insights into general education…

  6. Guided Reading in Inclusive Middle Years Classrooms

    ERIC Educational Resources Information Center

    Lyons, Wanda; Thompson, Scott Anthony

    2012-01-01

    Teachers in inclusive classrooms are challenged to provide reading instruction for students with a wide range of instructional levels. This article reports on the implementation of guided reading in four middle years inclusive classrooms, the impact on student engagement and reading progress, and teacher perspectives on the guided reading…

  7. School Inclusion and the "Community of Practice"

    ERIC Educational Resources Information Center

    Laluvein, Jackie

    2010-01-01

    "Inclusion" is not a mechanism for relocating educationally disadvantaged youngsters in mainstream rather than in special schools. Rather, inclusion implies a whole school approach to social relations and production of meaning reached through processes of negotiation between parents, teachers and children. Such an approach places equal value upon…

  8. The Sustainable Development of Inclusive Education

    ERIC Educational Resources Information Center

    Lo, Leslie Nai-kwai

    2007-01-01

    The advent of inclusive education has quietly changed the ecology of Hong Kong's educational system. Inclusive education is a product of education in the developed Western nations and has spread at the instigation of international organizations. It is a plan for educational development that is based on the concepts of human rights and peace and…

  9. Early Childhood Inclusion in the United Kingdom

    ERIC Educational Resources Information Center

    Blackburn, Carolyn

    2016-01-01

    A policy-to-practice paper is presented of early childhood inclusion in England. The article aims to report the benefits of early intervention services and early childhood inclusion for children with special educational needs and disabilities (SEND), document the chronology of policy development, and discuss research evidence about…

  10. Effective Leadership Makes Schools Truly Inclusive

    ERIC Educational Resources Information Center

    McLeskey, James; Waldron, Nancy L.

    2015-01-01

    There's been much commitment and extensive legislation intended to make schools inclusive for all students but not much real progress in improving student outcomes. The authors review and assess several schools that have succeeded at making schools inclusive and effective for all students, including those with disabilities and draw some inferences…

  11. Antisense-mediated exon inclusion

    PubMed Central

    Hua, Yimin; Krainer, Adrian R

    2012-01-01

    Exon skipping induced by gene mutations is a common mechanism responsible for many genetic diseases. A practical approach to correct the aberrant splicing of defective genes is to use antisense oligonucleotides (ASOs). The recognition of splice sites and the regulation of splicing involve multiple positive or negative cis-acting elements and trans-acting factors. Base-pairing of ASOs to a negative element in a targeted pre-mRNA blocks the binding of splicing repressors to this cis-element and/or disrupts an unfavorable secondary structure; as a result, the ASO restores exon inclusion. For example, we have recently shown that appropriate 2’-O-(2-methoxyethyl) (MOE) phosphorothioate-modified ASOs can efficiently correct survival motor neuron 2 (SMN2) exon 7 splicing in a cell-free splicing assay, in cultured human cells—including patient fibroblasts—and in both peripheral tissues and the CNS of SMA mouse models. These ASOs are promising drug leads for SMA therapy. PMID:22454070

  12. Full inclusion and students with autism.

    PubMed

    Mesibov, G B; Shea, V

    1996-06-01

    The concept of "full inclusion" is that students with special needs can and should be educated in the same settings as their normally developing peers with appropriate support services, rather than being placed in special education classrooms or schools. According to advocates the benefits of full inclusion are increased expectations by teachers, behavioral modeling of normally developing peers, more learning, and greater self-esteem. Although the notion of full inclusion has appeal, especially for parents concerned about their children's rights, there is very little empirical evidence for this approach, especially as it relates to children with autism. This manuscript addresses the literature on full inclusion and its applicability for students with autism. Although the goals and values underlying full inclusion are laudable, neither the research literature nor thoughtful analysis of the nature of autism supports elimination of smaller, highly structured learning environments for some students with autism. PMID:8792264

  13. Inclusive fitness maximization: An axiomatic approach.

    PubMed

    Okasha, Samir; Weymark, John A; Bossert, Walter

    2014-06-01

    Kin selection theorists argue that evolution in social contexts will lead organisms to behave as if maximizing their inclusive, as opposed to personal, fitness. The inclusive fitness concept allows biologists to treat organisms as akin to rational agents seeking to maximize a utility function. Here we develop this idea and place it on a firm footing by employing a standard decision-theoretic methodology. We show how the principle of inclusive fitness maximization and a related principle of quasi-inclusive fitness maximization can be derived from axioms on an individual׳s 'as if preferences' (binary choices) for the case in which phenotypic effects are additive. Our results help integrate evolutionary theory and rational choice theory, help draw out the behavioural implications of inclusive fitness maximization, and point to a possible way in which evolution could lead organisms to implement it. PMID:24530825

  14. Stress Field Caused by Polygonal Inclusion

    NASA Astrophysics Data System (ADS)

    Nozaki, Hideaki; Horibe, Tadashi; Taya, Minoru

    In this paper, we analyze the elastic field caused by an arbitrary polygonal inclusion (with uniform eigenstrain prescribed) in an infinite elastic solid. Closed-form solutions are obtained using Green’s function technique. Numerical calculations are performed for the strain and stress distributions in and around a regular polygonal inclusion. It is shown that logarithmic-type stress singularity at each corner of the inclusion may vanish only for a square inclusion of a specific orientation. Unique properties of the Eshelby tensor of a regular polygonal inclusion found by Nozaki and Taya [ASME J. Appl. Mech., Vol. 64, 1997, pp. 495-502] are also investigated in detail and the terms that cause the properties are specified.

  15. Hamiltonian inclusive fitness: a fitter fitness concept

    PubMed Central

    Costa, James T.

    2013-01-01

    In 1963–1964 W. D. Hamilton introduced the concept of inclusive fitness, the only significant elaboration of Darwinian fitness since the nineteenth century. I discuss the origin of the modern fitness concept, providing context for Hamilton's discovery of inclusive fitness in relation to the puzzle of altruism. While fitness conceptually originates with Darwin, the term itself stems from Spencer and crystallized quantitatively in the early twentieth century. Hamiltonian inclusive fitness, with Price's reformulation, provided the solution to Darwin's ‘special difficulty’—the evolution of caste polymorphism and sterility in social insects. Hamilton further explored the roles of inclusive fitness and reciprocation to tackle Darwin's other difficulty, the evolution of human altruism. The heuristically powerful inclusive fitness concept ramified over the past 50 years: the number and diversity of ‘offspring ideas’ that it has engendered render it a fitter fitness concept, one that Darwin would have appreciated. PMID:24132089

  16. Genetics Home Reference: intranuclear rod myopathy

    MedlinePlus

    ... 10.1055/s-2008-1065356. Citation on PubMed Laing NG, Dye DE, Wallgren-Pettersson C, Richard G, Monnier ... Wallgren-Pettersson C, Romero N, Nonaka I, Laing NG. Muscle disease caused by mutations in the skeletal ...

  17. Nickel and chromium isotopes in Allende inclusions

    NASA Technical Reports Server (NTRS)

    Birck, J. L.; Lugmair, G. W.

    1988-01-01

    High-precision nickel and chromium isotopic measurements were carried out on nine Allende inclusions. It is found that Ni-62, Ni-64, excesses are present in at least three of the samples. The results suggest that the most likely mechanism for the anomalies is a neutron-rich statistical equilibrium process. An indication of elevated Ni-60 is found in almost every inclusion measured. This effect is thought to be related to the decay of now extinct Fe-60. An upper limit of 1.6 X 10 to the -6th is calculated for the Fe-60/Fe-56 ratio at the time these Allende inclusions crystallized.

  18. Basophilic inclusions and neuronal intermediate filament inclusions in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.

    PubMed

    Ito, Hidefumi

    2014-12-01

    Basophilic inclusions (BIs) and neuronal intermediate filament inclusions (NIFIs) are key structures of basophilic inclusion body disease and neuronal intermediate filament inclusion disease (NIFID), respectively. BIs are sharply-defined, oval or crescent neuronal intracytoplasmic inclusions that appear pale blue-gray in color with HE staining and purple in color with Nissl but are stained poorly with silver impregnation techniques. Immunohistochemically BIs are negative for tau, trans-activation response DNA 43 (TDP-43), α-synuclein, neurofilament (NF) and α-internexin, positive for p62, and variably ubiquitinated. Noticeably, BIs are consistently fused in sarcoma (FUS) positive. NIFIs are by definition immuno-positive for class IV IFs including three NF triplet subunit proteins and α-internexin but negative for tau, TDP-43, and α-synuclein. In NIFID cases several types of inclusions have been identified. Among them, hyaline conglomerate-like inclusions are the only type that meets the above immunohistochemical features of NIFIs. This type of inclusion appears upon HE staining as multilobulated, faintly eosinophilic or pale amphophilic spherical masses with a glassy appearance. These hyaline conglomerates appear strongly argyrophilic, and robustly and consistently immuno-positive for IFs. In contrast, this type of inclusion shows no or only occasional dot-like FUS immunoreactivity. Therefore, BIs and NIFIs are distinct from each other in terms of morphological, tinctorial and immunohistochemical features. However, basophilic inclusion body disease (BIBD) and NIFID are difficult to differentiate clinically. Moreover, Pick body-like inclusions, the predominant type of inclusions seen in NIFID, are considerably similar to the BIs of BIBD in that this type of inclusion is basophilic, poorly argyrophilic, negative for IFs and intensely immuno-positive for FUS. As BIBD and NIFID share FUS accumulation as the most prominent molecular pathology, whether these two

  19. The interaction between inclusions and cracks

    NASA Technical Reports Server (NTRS)

    Erdogan, F.

    1973-01-01

    Some current fracture theories are reviewed and a group of mechanics problems of practical interest relating to the elastic interaction between cracks and inclusions are identified and results summarized.

  20. Inclusive Deep Inelastic Scattering at HERA

    SciTech Connect

    Newman, Paul

    2011-07-15

    Recent inclusive charged and neutral current scattering data from HERA are presented. Emphasis is placed on the resulting constraints on the proton parton densities and on the influence of low x proton structure on diffraction.

  1. Analysis of fluid inclusions in halite

    SciTech Connect

    Lazar, B.; Holland, H.D.

    1988-02-01

    A technique has been developed to drill into fluid inclusions in halite, to extract the inclusions fluids, and to determine the concentration of all of the major and some of the minor constituents in these fluids. The minimum diameter of usable fluid inclusions is ca. 250 ..mu..m. After dilution, the fluids are analyzed by ion chromatography and coulometry. Uncertainties in the concentration of the major cations and anions is on the order of 4%. The analytical scheme provides much more precise analyses of inclusion fluids than have been available to date. The analyses are a useful starting point for reconstructing the composition of the sea water from which the evaporite brines evolved.

  2. Genetics Home Reference: microvillus inclusion disease

    MedlinePlus

    ... of nutrients from food during digestion, resulting in malnutrition and dehydration. Affected infants often have difficulty gaining ... and fluids during digestion leads to recurrent diarrhea, malnutrition, and dehydration in individuals with microvillus inclusion disease . ...

  3. 75 FR 81395 - Minority and Women Inclusion

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ...\\ See 75 FR 10446, March 8, 2010. FHFA received 23 comment letters to the proposed rule from individuals... FHFA should not require the creation of Offices of Minority and Women Inclusion and should let...

  4. Water loss from olivine hosted melt inclusions

    NASA Astrophysics Data System (ADS)

    Chen, Y.; Provost, A.; Schiano, P.; Cluzel, N.

    2009-12-01

    Water content in melt inclusions has long been used as an important index for the water content of the hosting magma. However, many studies have shown that post-entrapment diffusive re-equilibration can affect the water content of melt inclusions. This process must be considered when using melt inclusions to infer water content of the hosting magma. Theoretical model on the diffusive re-equilibration between melt inclusions and external melts showed that the re-equilibration rate depends on the diffusivity of the re-equilibrating species in the host mineral, the partition coefficient of this species between the host mineral and melt, and the geometry of the melt inclusion and host mineral. The water diffusivity in olivine and water partition coefficient between melt and olivine have been measured by recent studies, therefore the diffusive re-equilibration model can be tested by experiments. In this study, we carried out in-situ Fourier transform infrared spectroscopy (FTIR) measurements on the water content of olivine hosted melt inclusions at high temperatures. Initial water content of the melt inclusions is about 4 wt%. A heating stage system is combined with a microscope FTIR and the absorption spectrum through the olivine and melt inclusion is repeatedly measured. Although the absorption band at around 3540 cm-1 has not be calibrated at high temperatures, it is assumed that the absorbance is linearly related to the total water concentration in the melt inclusion, and the relative water content can be inferred. Cautions have been exercised to maintain a consistent measurement spot such that the thickness of the melt inclusion within the beam path did not change significantly during each experiment. Oxygen fugacity in the heating stage is controlled by Zr purified Ar gas to be about 7 logarithm units below the QFM buffer and about 1 logarithm unit above the QIF buffer at 1473 K. Preliminary results showed that at 1430 and 1581 K, the total water content of the

  5. Unusual inclusions found in a national diamond

    SciTech Connect

    Leung, I.S.

    1985-01-01

    Three pale yellow minerals, 100-200 microns in their longest dimension, were extracted from a diamond 2.5 mm in size and examined in an SEM equipped with an X-ray energy-dispersive spectrometer. These inclusions were found to be two grains of garnet and a coesite, all of which contain a microscopic grain of Ti-rich biotite, a small amount of sanidine and a number of other minerals. (1) Garnet-biotite-apatite-rutile-sanidine-(Fe,Ca) melt. Attached to one end of this garnet inclusion is a crystal of biotite (50 x 30 ..mu..m) in which an apatite and a rutile are embedded. A thin lamella of sanidine occurs in the biotite near the garnet boundary. (2) Garnet-biotite-apatite-sanidine-rutile-pyrrhotite-(Fe,Ca,K) phase (unidentified). This garnet inclusion partially encased a biotite crystal while all other phases occur as minute prismatic needles or irregular and globular masses on the inclusion surface. (3) Coesite-biotite-sanidine-calcite. They are considered primary phases because the diamond host contains neither internal nor external fractures. Garnet, coesite, biotite and apatite are syngenetic inclusions in this diamond based on their relatively large sizes and their intergrown relationships. All other phases may also be primary or derived from biotite which, in the presence of sulfur, may produce phlogopite + sanidine + pyrrhotite + rutile. The droplets of melt and thin lamella of sanidine in inclusion (1) seem to be products of incongruent melting of biotite during the emplacement of kimberlite.

  6. Threshold size for fluid inclusion decrepitation

    NASA Astrophysics Data System (ADS)

    Campione, Marcello; Malaspina, Nadia; Frezzotti, Maria Luce

    2015-11-01

    Fluid inclusions in igneous and metamorphic rocks are equilibrated at pressures reaching a few tens of kilobars at mantle depths. These microsystems experience decompression as a consequence of uplift processes, such as subaerial volcanic eruptions. On decompression, inclusion fluid overpressure is known to bring about the mechanical failure of the crystal matrix through either stretch or decrepitation, depending on ductile or brittle failure mechanism of the matrix, respectively. On the one hand, laboratory experiments performed on synthetic inclusions at one atmosphere show that the decrepitation temperature is strongly size dependent, with the smaller cavities observed to decrepitate at higher temperatures. On the other hand, natural fluid inclusions, which undergo migration through a pressure gradient, are often found intact below a critical size. Here by modeling fluid inclusions as spherical cavities in a continuous elastic medium and by adopting a nonlocal stress approach to fracturing, we demonstrate that the decrepitation phenomenon is predicted to be characterized by a threshold size of the cavity, below which decrepitation would not be allowed. In order to validate our model, two independent experimental data sets relating internal pressure to cavity size are utilized to calculate pertinent model parameters and to evaluate their consistency.

  7. The Inclusion of Inclusive Education in International Development: Lessons from Papua New Guinea

    ERIC Educational Resources Information Center

    Le Fanu, Guy

    2013-01-01

    A new "inclusive" curriculum has been introduced in Papua New Guinea, with significant levels of support from a bilateral development agency. The curriculum is inclusive in the sense that it is designed to meet the diverse, complex, and ever-changing needs of students. Research indicates the curriculum has been shaped by various influences, most…

  8. Inclusion in Play: A Case Study of a Child with Autism in an Inclusive Nursery

    ERIC Educational Resources Information Center

    Theodorou, Fani; Nind, Melanie

    2010-01-01

    This paper discusses the play interaction of a young child with autism and the strategies adopted by her teachers to facilitate her inclusion in and through play. The data are from an ethnographic case study in an inclusive nursery in the South of England spanning 6 months. The aim was to understand and describe the play of a child with autism in…

  9. Inclusion and the Law: Two Laws--IDEA and Section 504--Support Inclusion in Schools

    ERIC Educational Resources Information Center

    Taylor, Kelley R.

    2011-01-01

    As someone charged with ensuring equality in the school environment, teachers have heard the term "inclusion"--the principle that students with special needs, skill sets, and abilities should be integrated in publicly supported activities to the same extent as their nondisabled peers. However, the word inclusion--in and of itself--does not…

  10. Leadership for Inclusion: Conceptualising and Enacting Inclusion in Integrated Schools in a Troubled Society

    ERIC Educational Resources Information Center

    McGlynn, Claire; London, Tim

    2013-01-01

    Inclusion is increasingly understood as an educational reform that responds to the diversity of all learners, challenging the marginalisation, exclusion and underachievement which may result from all forms of "difference". Leadership for inclusion is conceptualised here as driving a constant struggle to create shared meanings of…

  11. Insights into Inclusive Education through a Small Finnish Case Study of an Inclusive School Context

    ERIC Educational Resources Information Center

    Tarr, Jane Mary; Tsokova, Diana; Takkunen, Ulla-Maija

    2012-01-01

    This study seeks to present data and discussion arising from a case study of a school in Finland renowned for its practice in the inclusion of learners with additional support requirements due to cognitive and physical disabilities. It aims to establish how the school staff understand their practice with inclusion through day-to-day professional…

  12. Inclusive Education: Identifying Teachers' Strategies for Coping with Perceived Stressors in Inclusive Classrooms

    ERIC Educational Resources Information Center

    Brackenreed, Darlene

    2011-01-01

    This research replicates the study conducted by Forlin (2001) in Churchlands, Western Australia. Forlin's Inclusive Education "Teacher Stress and Coping Questionnaire" was adapted from the original questionnaire to more accurately reflect the language and practice of inclusion in Ontario. The purpose of this portion of the study was to determine…

  13. Exploring the Landscape of Inclusion: Profiles of Inclusive versus Segregated School Districts in the United States

    ERIC Educational Resources Information Center

    Marks, Susan Unok; Kurth, Jennifer A.; Bartz, Jody Marie

    2014-01-01

    Although inclusive education has been increasing in frequency for students with disabilities in the United States, for many students, the opportunity to be educated with their peers without disabilities continues to be out of reach despite decades of efforts by those promoting the vision of inclusion. This exploratory case study used interviews…

  14. When Inclusion Is Innovation: An Examination of Administrator Perspectives on Inclusion in China

    ERIC Educational Resources Information Center

    Hu, Bi Ying; Roberts, Sherron Killingsworth

    2011-01-01

    This article examines administrator perspectives of innovative services for the inclusion of young children with disabilities in regular preschool classrooms in China. Twelve directors from 12 pilot inclusion preschools in Beijing participated in this study. Qualitative interview results revealed the following subthemes: definition, advocacy,…

  15. Characteristics of Inclusive Faith Communities: A Preliminary Survey of Inclusive Practices in the United States

    ERIC Educational Resources Information Center

    Griffin, Megan M.; Kane, Lydia W.; Taylor, Courtney; Francis, Susan H.; Hodapp, Robert M.

    2012-01-01

    Background: Although participation in faith communities is important to many individuals with disabilities, few studies have examined differences between communities that are more (versus less) inclusive. This study investigated characteristics of faith communities in the United States related to greater inclusion. Methods: Participants were 160…

  16. Language and Social Inclusion: Unexplored Aspects of Intercultural Communication

    ERIC Educational Resources Information Center

    Musgrave, Simon; Bradshaw, Julie

    2014-01-01

    Social inclusion policy in Australia has largely ignored key issues of communication for linguistic minorities, across communities and with the mainstream community. In the (now disbanded) Social Inclusion Board's reports (e.g., Social Inclusion Unit, 2009), the emphasis is on the economic aspects of inclusion, while little attention has been…

  17. An Arendtian Perspective on Inclusive Education: Towards a Reimagined Vocabulary

    ERIC Educational Resources Information Center

    Korsgaard, Morten Timmermann

    2016-01-01

    Inclusive education currently appears to be undergoing a crisis and re-examination. This paper presents a new approach to thinking about inclusiveness in the school context. Many positions within inclusive education seem to take political, social and ethical perspectives as a starting point, which has allowed inclusive movements and initiatives…

  18. Exploring Preservice Teachers' Attitudes Towards Inclusion

    ERIC Educational Resources Information Center

    Killoran, Isabel; Woronko, Dagmara; Zaretsky, Hayley

    2014-01-01

    This study responds to a call for research into existing teacher-education programmes and their impact on teacher candidates' attitudes. An inclusive education course that examined the difference between "soft inclusion" (inclusion which addresses the issue of place rather than substance of learning) and genuine inclusion was used…

  19. Electronic Impact of Inclusions in Diamond

    SciTech Connect

    Muller, E.M.; Smedley, J.; Raghothamachar, B.; Gaowei, M.; Keister, J.W.; Ben-Zvi, I.; Dudley, M.; Wu, Q.

    2010-04-07

    X-ray topography data are compared with photodiode responsivity maps to identify potential candidates for electron trapping in high purity, single crystal diamond. X-ray topography data reveal the defects that exist in the diamond material, which are dominated by non-electrically active linear dislocations. However, many diamonds also contain defects configurations (groups of threading dislocations originating from a secondary phase region or inclusion) in the bulk of the wafer which map well to regions of photoconductive gain, indicating that these inclusions are a source of electron trapping which affect the performance of diamond X-ray detectors. It was determined that photoconductive gain is only possible with the combination of an injecting contact and charge trapping in the near surface region. Typical photoconductive gain regions are 0.2 mm across; away from these near-surface inclusions the device yields the expected diode responsivity.

  20. Potassium in clinopyroxene inclusions from diamonds.

    PubMed

    Harlow, G E; Veblen, D R

    1991-02-01

    Analytical transmission electron microscopy, electron microprobe analyses, and singlecrystal x-ray diffraction data support the conclusion that high potassium contents, up to 1.5 weight percent K(2)O, of some diopside and omphacite inclusions from diamonds represent valid clinopyroxene compositions with K in solid solution. This conclusion contradicts the traditional view of pyroxene crystal chemistry, which holds that K is too large to be incorporated in the pyroxene structure. These diopside and omphacite inclusions have a high degree of crystal perfection and anomalously large unit-cell volumes, and a defect-free structure is observed in K-bearing regions when imaged by transmission electron microscopy. These observations imply that clinopyroxene can be a significant host for K in the mantle and that some clinopyroxene inclusions and their diamond hosts may have grown in a highly K-enriched environment. PMID:17741381

  1. Inclusion probability with dropout: an operational formula.

    PubMed

    Milot, E; Courteau, J; Crispino, F; Mailly, F

    2015-05-01

    In forensic genetics, a mixture of two or more contributors to a DNA profile is often interpreted using the inclusion probabilities theory. In this paper, we present a general formula for estimating the probability of inclusion (PI, also known as the RMNE probability) from a subset of visible alleles when dropouts are possible. This one-locus formula can easily be extended to multiple loci using the cumulative probability of inclusion. We show that an exact formulation requires fixing the number of contributors, hence to slightly modify the classic interpretation of the PI. We discuss the implications of our results for the enduring debate over the use of PI vs likelihood ratio approaches within the context of low template amplifications. PMID:25559642

  2. History of Inclusive Design in the UK.

    PubMed

    John Clarkson, P; Coleman, Roger

    2015-01-01

    The UK Design Council describes Inclusive Design as neither a new genre of design, nor a separate specialism, but as a general approach to designing in which designers ensure that their products and services address the needs of the widest possible audience, irrespective of age or ability. Inclusive Design (also known [in Europe] as Design for All and as Universal Design in the USA) is in essence the inverse of earlier approaches to designing for disabled and elderly people as a sub-set of the population, and an integral part of a more recent international trend towards the integration of older and disabled people in the mainstream of society. This paper describes the development of Inclusive Design in the UK, from its early beginnings, through its subsequent adoption as a topic of academic research, leading to its recent emergence embodied as a framework and toolkit for design. PMID:23570838

  3. Anisotropy of Silicate-Hosted Magnetite Inclusions

    NASA Astrophysics Data System (ADS)

    Scott, G. R.; Feinberg, J. M.; Renne, P. R.

    2004-12-01

    Anisotropy of magnetic properties is a hallmark of silicate crystals with oriented iron-oxide inclusions. Strongly magnetic magnetite-bearing silicates (10-1 A m-1) are common components of gabbros and layered intrusions, contributing to local and regional magnetic anomalies. Additionally, these iron-oxide silicates hold the promise of being exceptional paleomagnetic recorders owing to their features of: physical/chemical isolation from altering fluids, chemical equilibrium with their silicate host, and long relaxation times (enhanced coercivity). However, anisotropy of remanence must be understood before these advantageous features can be utilized. Measurements of single crystals of clinopyroxene and plagioclase (10-4 g) show anisotropy in direction and intensity that directly reflect the crystallography of the silicate host. The host controls both the crystallographic orientation of the magnetite (magnetocrystalline anisotropy) and the elongation direction of the magnetite inclusion (shape anisotropy). We have found another source of anisotropy that involves an internal exsolution of ulvöspinel within titanomagnetite inclusions. This also reflects a host control as this second exsolution occurs along the magnetite \\{100\\}. This fixed wall shape anisotropy creates an array of interacting single domain magnetite parallelepipeds, parallel to \\{100\\}. Each of these anisotropies contributes to enhanced coercivity of remanence, which significantly exceeds the IRM saturation magnetization for magnetite (300 mT). The anisotropy of IRM (aIRM@ 1.1 T) of magnetite-bearing clinopyroxene and plagioclase shows clustering of directions, reflecting the mixture of variables that include: inclusion elongation direction and abundance, orientation of magnetite easy axes relative to the applied field, inclusion aspect ratio and diameter, and pre-existing magnetic domain structure. For pyroxene (monoclinic) with two arrays of needle-shaped magnetite inclusions, the aIRM is

  4. Epithelial Inclusion Cyst in Conjunctival Melanoma.

    PubMed

    Esposito, Evangelina; Zoroquiain, Pablo; Mastromonaco, Christina; Morales, Melina C; Belfort Neto, Rubens; Burnier, Miguel

    2016-09-01

    Conjunctival melanoma is the second most common conjunctival malignancy. Its differential diagnosis with other conjunctival melanocytic neoplasms is inherently difficult. The presence of epithelial cysts is a useful feature in conjunctival tumors and favors a benign lesion. Herein 2 cases of conjunctival melanoma with cysts are presented. To the best of our knowledge, this is the first series of conjunctival melanoma with epithelial inclusion cysts. This series emphasizes the importance of considering several malignant features when reviewing conjunctival melanocytic lesions, as malignancy can exist even in the presence of epithelial inclusion cysts. PMID:27160434

  5. From Inclusion for Some to Inclusion for All: A Case Study of the Inclusion Program at One Catholic Elementary School

    ERIC Educational Resources Information Center

    Paz, Emily

    2013-01-01

    Catholic schools in the United States have grappled with how to serve students with disabilities without the funding sources available to public schools. This mixed methods case study examines the driving forces, restraining forces, and social justice issues that influenced the development of an inclusion program at one Catholic elementary school.…

  6. Solid inclusion thermobarometry under fire: Heating experiments on encapsulated quartz inclusions in garnet

    NASA Astrophysics Data System (ADS)

    Ashley, Kyle T.; Steele-MacInnis, Matthew; Bodnar, Robert J.; Darling, Robert S.

    2016-04-01

    Internal pressures of mineral inclusions (Pincl) result from differences in elastic properties of the inclusion mineral and its host mineral. Recent studies utilize pressure-sensitive Raman spectroscopic waveshifts to determine the retained Pincl and apply elastic theory to estimate pressure (or temperature) conditions of entrapment. Quartz inclusions are commonly utilized because quartz is a "soft," compressible mineral that is ubiquitous as an inclusion phase in continental metamorphic rocks. Garnet is a commonly used host because it is rigid and isotropic. Quartz inclusions trapped in garnet at high-P, low-T conditions will retain high Pincl; whereas those trapped at low-P, high-T conditions yield negative waveshifts equating to "negative" pressure, or net tensile stress on the inclusion. While Pincl can be accurately calculated from Raman data, barometry relies also upon the quality of the elastic model, which fundamentally depends on the quality of the P ‑V ‑T equations of state (EOS) applied. For quartz, EOS modeling is challenging due to the spontaneous strain that develops close to the lambda transition. In this study we conduct heating experiments on quartz inclusions in garnet from natural samples to assess the response of inclusion pressure to varying temperature (at ambient external pressure), and to evaluate predictions based on commonly applied EOS. Experiments were conducted on two quartz standards (a Herkimer "diamond" and Brazillian quartz) and four completely encapsulated inclusions of quartz in garnet from three tectonically diverse terranes, including: (i) a dilated quartz inclusion (Pincl = -4.3 kbar) from Port Leyden, Adirondack Mountains, New York, (ii) a Barrovian-sequence quartz inclusion from northern Scotland (Pincl = 3.1 kbar), and (iii) two high-pressure (blueschist) quartz inclusions from Sifnos, Greece (Pincl = 7.7 and 8.9 kbar). Standards were heated in 25 ° C increments with smaller increments near the lambda transition. Quartz

  7. When social inclusion is not enough: Implicit expectations of extreme inclusion in borderline personality disorder.

    PubMed

    De Panfilis, Chiara; Riva, Paolo; Preti, Emanuele; Cabrino, Chiara; Marchesi, Carlo

    2015-10-01

    Increasing evidence suggests that individuals with borderline personality disorder (BPD) might feel rejected even when socially included by others. A psychological mechanism accounting for this response bias could be that objective social inclusion violates BPD patients' underlying implicit needs of "extreme" inclusion. Thus, this study investigated whether, during interpersonal exchanges, BPD patients report more rejection-related negative emotions and less feelings of social connection than controls unless they are faced with conditions of extreme social inclusion. Sixty-one BPD patients and 61 healthy controls completed a modified Cyberball paradigm. They were randomly assigned to a condition of ostracism, social inclusion, or overinclusion (a proxy for extreme social inclusion). They then rated their emotional states and feelings of social connection immediately and 20 min after the game. BPD patients reported greater levels of negative emotions than controls in the ostracism and the inclusion conditions, but not when overincluded. Furthermore, only for BPD participants was overinclusion associated with experiencing less negative emotions than the ostracism condition. However, BPD patients reported lower feelings of social connection than controls in any experimental situation. Thus, in BPD, a laboratory condition of "overinclusion" is associated with a reduction of negative emotions to levels comparable to those of control participants, but not with similar degrees of social connection. These results suggest that for BPD patients, even "including contexts" activate feelings of rejection. Their implicit expectations of idealized interpersonal inclusion may nullify the opportunity of experiencing "real" social connection and explain their distorted subjective experiences of rejection. PMID:26147068

  8. Economic and Demographic Predictors of Inclusive Education

    ERIC Educational Resources Information Center

    Cosier, Meghan E.; Causton-Theoharis, Julie

    2011-01-01

    This study investigated economic and demographic predictors of levels of inclusion of students with disabilities in 129 school districts. Multiple regression analysis was utilized to address the following research questions: (a) Is there a relationship between economic factors and percentage of highly included students with disabilities in general…

  9. Expanding Opportunities: An Interagency Inclusion Initiative

    ERIC Educational Resources Information Center

    National Early Childhood Technical Assistance Center (NECTAC), 2010

    2010-01-01

    Research has shown that both young children with disabilities and their peers benefit from participating together in quality programs and community activities. However, inclusive opportunities for young children with disabilities are often not systematic, comprehensive or necessarily of high quality. Cross-agency dialogue and commitment among…

  10. Inclusive Standard Model Higgs searches with ATLAS

    SciTech Connect

    Polci, Francesco

    2008-11-23

    The update of the discovery potential for a Standard Model Higgs boson through the inclusive searches H{yields}{gamma}{gamma}, H{yields}ZZ* and H{yields}WW with the ATLAS detector is reported. The analysis are based on the most recent available simulations of signal, backgrounds as well as the detector response.

  11. Chrome pyrope: an inclusion in natural diamond.

    PubMed

    Meyer, H O

    1968-06-28

    Electron probe analyses of garnets that are rich in magnesium and that occur as inclusions in natural diamonds show that the chrome-garnet end member, Mg(3)Cr(2)Si(3)O(12), is a major constituent (30 percent). PMID:17817353

  12. Understanding Teachers' Concerns about Inclusive Education

    ERIC Educational Resources Information Center

    Yadav, Monika; Das, Ajay; Sharma, Sushama; Tiwari, Ashwini

    2015-01-01

    This study examined the concerns of regular elementary school teachers in Gurgaon, India, in order to work with students with disabilities in inclusive education settings. A total of 175 teachers responded to a two-part questionnaire. Data were analyzed using descriptive and inferential statistics. The data indicated that the teachers in Gurgaon,…

  13. Cooperative Oriented Learning in Inclusive Physical Education

    ERIC Educational Resources Information Center

    Klavina, Aija; Jerlinder, Kajsa; Kristén, Lars; Hammar, Lena; Soulie, Tine

    2014-01-01

    In this study the implementation of cooperation directed learning of peer tutoring in elementary general inclusive physical education (GPE) setting in three elementary city schools in Sweden was studied. The purpose was to assess the impact of peer tutoring on the interaction behaviours between students with and without disabilities in GPE. A…

  14. Transformative Pathways: Inclusive Pedagogies in Teacher Education

    ERIC Educational Resources Information Center

    Guojonsdottir, Hafdis; Cacciattolo, Marcelle; Dakich, Eva; Davies, Anne; Kelly, Claire; Dalmau, Mary C.

    2008-01-01

    This paper reports a three-year study of Praxis Inquiry based developments in teacher education undertaken by an international consortium of university colleagues who have worked in Australia, Iceland, Latvia, and the United Kingdom. Our study suggests that the attainment of inclusive community responsive pedagogies--in schools and in teacher…

  15. Inclusion in PK-12: An International Perspective

    ERIC Educational Resources Information Center

    Curcic, Svjetlana

    2009-01-01

    With an aim to investigate inclusion across borders, quantitative and qualitative data were examined that came from 18 countries: Australia, Brazil, Canada, Cyprus, Finland, France, Iceland, India, Ireland, the Netherlands, Norway, Portugal, Slovenia, South Africa, Spain, Sweden, the UK, and the USA. Four themes emerged in this study: (1) concerns…

  16. Creating Inclusive Schools for All Students

    ERIC Educational Resources Information Center

    Causton-Theoharis, Julie; Theoharis, George

    2008-01-01

    In this article, a former principal at Falk Elementary School in Madison, Wisconsin, describes his school's shift as it sought to create an inclusive school for all students and establish an authentic sense of belonging. Nationwide, schools and districts from Concord, New Hampshire, to Whittier, California, and from Cambridge, Massachusetts, to…

  17. Assistive Technology: Supporting Learners in Inclusive Classrooms

    ERIC Educational Resources Information Center

    Simpson, Cynthia G.; McBride, Rebecca; Spencer, Vicky G.; Lowdermilk, John; Lynch, Sharon

    2009-01-01

    Over the past 10 years, the numbers of students with physical disability who are being educated in inclusive or universal design for learning (UDL) classrooms have been increasing steadily. These students are expected to complete grade-level assignments, but not all of them are provided the necessary supports to do so. Many teachers in inclusive…

  18. Inclusion: Professional Development Needs of Educators

    ERIC Educational Resources Information Center

    Stocks, Amanda G.

    2010-01-01

    An attitudinal resistance among teachers regarding the inclusion of children with disabilities is well documented in the literature. Studies collectively highlight two specific areas that contribute to this resistance. First, a lack of teacher knowledge or preparedness for meeting the diverse needs of children with disabilities stimulates…

  19. Disabilities and Inclusive Practices within Toronto Preschools

    ERIC Educational Resources Information Center

    Killoran, Isabel; Tymon, Dorothy; Frempong, George

    2007-01-01

    A current objective in Canada is a provision of childcare services for all children. This objective has not been achieved as many children, especially those with disabilities, are often denied services from publicly funded daycare centres. The authors argue that policy discussions framed from an inclusive perspective provide a better understanding…

  20. Full Inclusion: The Least Restrictive Environment

    ERIC Educational Resources Information Center

    Mullings, Shirley E.

    2011-01-01

    The purpose of the phenomenological study was to examine elementary educators' perceptions of full inclusion as the least restrictive environment for students with disabilities. Thirty-six teachers and administrators participated in interviews and responded to multiple-choice survey items. The recorded data from the interviews were…

  1. Testing Accommodations and Inclusive Assessment Practices

    ERIC Educational Resources Information Center

    Niebling, Bradley C.; Elliott, Stephen N.

    2005-01-01

    The inclusion of students with disabilities in large-scale assessments, typically by using testing accommodations, for statewide accountability systems became a legal reality with the reauthorization of the Individuals with Disabilities Education Act in 1997, and the passage of the No Child Left Behind Act in 2002. These legal mandates and best…

  2. If You Can: Inclusion in Music Making

    ERIC Educational Resources Information Center

    Allan, Julie; Cope, Peter

    2004-01-01

    This paper steps outside of conventional frameworks of schooling and examines inclusion from the perspective of eight young people and adults who play Scottish fiddle music in a group. The participants were asked to talk about their experiences of playing and their involvement with the group in practice and performance sessions. The group had been…

  3. Recent Developments in Inclusive Education in Malta.

    ERIC Educational Resources Information Center

    Bartolo, Paul A.

    2001-01-01

    Examines recent developments in Malta's inclusive education policy, discourse, and practice, noting the influence of United Nations policies, local political developments, parent associations, a National Commission for Persons with Disabilities, and a nongovernmental organization for persons with developmental disabilities. Discusses the…

  4. The Value of Connectedness in Inclusive Teaching

    ERIC Educational Resources Information Center

    Figueroa, Ivan

    2014-01-01

    The author addresses the importance of relationships in order for learning to take place in an inclusive manner. Anecdotes illustrate the value in beginning where the learner is and the unexpected opportunities the journey can lead to when both teacher and learner venture through unchartered paths together.

  5. Educational Technology for the Inclusive Classroom

    ERIC Educational Resources Information Center

    Starcic, Andreja Istenic

    2010-01-01

    This paper presents and evaluates the development of an educational technology curriculum aimed at pre-service, primary education and undergraduates; the focus is on the incorporation of ICT competences for inclusive education. The framework was the introduction of SEVERI e-learning environment in Slovenian schools. Students were able to monitor…

  6. Equity and Inclusion in Physical Education PLC

    ERIC Educational Resources Information Center

    Evans, John

    2014-01-01

    Physical Educationalists in many western and westernised societies across the globe are facing new challenges as system wide changes take place increasing the role of private bodies (e.g. Academy trusts) in the delivery of school based education. This reflective and rather personal paper considers the place and meaning of "inclusion" and…

  7. The SIO: An Instrument To Facilitate Inclusion.

    ERIC Educational Resources Information Center

    Saint-Laurent, Lise

    2001-01-01

    Discusses how as inclusive efforts became more prevalent in the 1970s, 80s, and 90s, the Individualized Education Program (IEP) came to be considered a key factor in achieving high quality services and instruction for students with disabilities. Describes a technique, the Summary of Individualized Objectives (SIO), for making IEP goals and…

  8. Comprehensive School Reform and Inclusive Schools

    ERIC Educational Resources Information Center

    McLeskey, James; Waldron, Nancy L.

    2006-01-01

    In spite of the emphasis in public policy and the professional literature on developing inclusive programs for students with disabilities over the past 30 years, surprisingly little progress has been made in this regard in school districts across the United States. One approach to change that is currently being used with some success in general…

  9. Inclusion in Practice: Sofia's Situations for Interaction

    ERIC Educational Resources Information Center

    Alexandersson, Ulla

    2011-01-01

    The aim of this article is to present findings from a study (Alexandersson, 2007) about how one student--called Sofia--with intellectual disability interacts and communicates with her classmates and her teachers in an inclusive setting. Furthermore, the aim is also to analyse in what way the interaction contributes to Sofia's social participation…

  10. Middle Schools Principals' Attitudes about Inclusion

    ERIC Educational Resources Information Center

    Lindsey, Gloria Denise

    2009-01-01

    Important legislation has demanded the education of students with disabilities in the least restrictive environment. Administrators, principals and educators in the local schools are impacted tremendously by this decision. The necessity to provide an appropriate education for special needs children while successfully implementing inclusion is a…

  11. Working towards Inclusion: Reflections from the Classroom

    ERIC Educational Resources Information Center

    Singal, Nidhi

    2008-01-01

    This article explores developments towards inclusive education being undertaken in some schools in India. Drawing on data collected through interviews with key professionals working in schools and classroom observations, the study focused on the practices and experiences of professionals involved in these efforts. Findings suggest that these…

  12. Strategies for Success in Inclusive Classrooms.

    ERIC Educational Resources Information Center

    Hay, Genevieve H.; Courson, Frances H.

    1997-01-01

    Suggests a popular model of service delivery for students with disabilities is full inclusion. Suggests regular classroom teachers should identify and focus on included students' strengths and carefully examine students' academic and social gains. Argues that school personnel should work in collaborative teams in which skills, experience, talents,…

  13. Inclusive Education--Empirical Experience from Serbia

    ERIC Educational Resources Information Center

    Kovacevic, Jasmina; Macesic-Petrovic, Dragana

    2012-01-01

    This descriptive study finds out the problems most frequently facing the children with special needs in regular schooling. The sample included 500 teachers in elementary schools from Serbia. The results point out the problems in inclusive education. Most educational problems occur in relations and communications with their peers in typical…

  14. "Shakespeare with Heart": An Inclusive Drama Project

    ERIC Educational Resources Information Center

    Wilkins, Ilene E.

    2008-01-01

    This article features Shakespeare with Heart, a two week inclusive summer program for middle and high school students with and without disabilities. The program runs each morning until noon, culminating with a workshop performance of a Shakespeare play with full costume and set with a live audience of parents, friends, and community members. The…

  15. Beyond Tracking: Finding Success in Inclusive Schools.

    ERIC Educational Resources Information Center

    Pool, Harbison, Ed.; Page, Jane A., Ed.

    This collection of papers addresses tracking, whether it should be abolished, the movement toward inclusiveness in schools, strategies to meet all students' needs, and the process of untracking. Contents are as follows: "Why Ability Grouping Must End: Achieving Excellence and Equity in American Education" (Jomills Henry Braddock II and Robert E.…

  16. Inclusion's Confusion in Alberta

    ERIC Educational Resources Information Center

    Gilham, Chris; Williamson, W. John

    2014-01-01

    This hermeneutic paper interprets a recent series of reforms to inclusive education policy undertaken by the ministry of education in the province of Alberta, Canada. A 2007 Alberta Education review of the 16,000 student files in the province that school boards had claimed met the criteria for severe disability codification status -- the level of…

  17. Dilemmas in the Quest for Inclusion

    ERIC Educational Resources Information Center

    Wedell, Klaus

    2005-01-01

    In 1995, on the occasion of his "retirement", Professor Klaus Wedell wrote a leading article for BJSE entitled "Making inclusive education ordinary". Last October, Professor Wedell, also known to BJSE's readers as the author of the regular "Points from the SENCo-Forum "column, delivered the Gulliford Lecture at Birmingham University. Here he makes…

  18. Paleotemperatures preserved in fluid inclusions in halite

    SciTech Connect

    Roberts, S.M.; Spencer, R.J.

    1995-10-01

    A variety of paleoclimate proxy records allow determination of relative warming or cooling. However, if we are to understand climate change, quantification of past temperature fluctuations is essential. Our research indicates that fluid inclusions in halite can yield homogenization temperatures that record surface brine temperatures at the time of halite precipitation. To avoid problems with stretching, leaking, and initial trapping of air, samples with primary, single-phase (liquid) fluid inclusions are chilled in a freezer to nucleate vapor bubbles. We tested the reliability of this method of obtaining fluid-inclusion homogenization temperatures using modern salts precipitated at Badwater Basin, Death Valley, California. Homogenization temperatures correlate well with measured brine temperatures. The same method is applied to fluid inclusions in Pleistocene halite from a core taken at the same location in Death Valley. Results are at several scales, recording diurnal temperature variations, seasonal temperature fluctuations, and longer-term warming and cooling events that correlate with major changes in the sedimentary environment related to climate. This technique is uniquely instrumental for paleoclimate studies because it offers actual, not just proxy, paleotemperature data. 27 refs., 17 figs.

  19. Final state interactions and inclusive nuclear collisions

    NASA Technical Reports Server (NTRS)

    Cucinotta, Francis A.; Dubey, Rajendra R.

    1993-01-01

    A scattering formalism is developed in a multiple scattering model to describe inclusive momentum distributions for high-energy projectiles. The effects of final state interactions on response functions and momentum distributions are investigated. Calculations for high-energy protons that include shell model response functions are compared with experiments.

  20. An Inclusive Process for Departmental Textbook Selection

    ERIC Educational Resources Information Center

    Altman, William S.; Ericksen, Kristen; Pena-Shaff, Judith B.

    2006-01-01

    This article reports on the development and use of an inclusive process to select a departmental textbook for general psychology. It describes a method for developing department-specific instruments to narrow the available textbook choices and an in-class textbook trial used in the final selection. Reported advantages of this method include…

  1. Hadronization Effects in Inclusive τ Decay

    NASA Astrophysics Data System (ADS)

    Nesterenko, A. V.

    2013-11-01

    It is shown that the nonperturbative effects due to hadronization play a crucial role in low-energy strong interaction processes. Specifically, such effects impose a stringent constraint on the infrared behavior of the Adler function and play an essential role in the theoretical analysis of inclusive τ lepton decay.

  2. 75 FR 1289 - Minority and Women Inclusion

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-11

    ...The Federal Housing Finance Agency (FHFA or agency) is issuing notice and opportunity for the public to comment on this proposed regulation on minority and women inclusion. Section 1116 of the Housing and Economic Recovery Act of 2008 amended section 1319A of the Federal Housing Enterprises Financial Safety and Soundness Act of 1992, requiring FHFA, the Federal National Mortgage Association,......

  3. Academic Freedom and the Inclusive University.

    ERIC Educational Resources Information Center

    Kahn, Sharon E., Ed.; Pavlich, Dennis, Ed.

    The chapters in this collection explore issues related to academic freedom and the inclusive university. The first section, Clarifying Concepts in Ideology, Language, and Law, contains these chapters: (1) Whats Sauce for One Goose: The Logic of Academic Freedom (Stanley Fish); (2) Academic Freedom: Rights as Immunities and Privileges (Frederick…

  4. Student Behaviour Self-Monitoring Enabling Inclusion

    ERIC Educational Resources Information Center

    Jull, Stephen K.

    2009-01-01

    Disruptive, antisocial behaviour remains an ongoing issue for all schools, and particularly those identified as inclusive. Children who exhibit elevated levels of antisocial behaviour have an increased risk of numerous negative life consequences, including impaired social relationships, escalating aggressive behaviours, substance abuse, and school…

  5. Everyday Inclusive Web Design: An Activity Perspective

    ERIC Educational Resources Information Center

    Kane, Shaun K.

    2007-01-01

    Introduction: Website accessibility is a problem that affects millions of people with disabilities. While most current accessibility initiatives target government or commercial sites, a growing segment of online content is being created by non-professionals. This content is often inaccessible to users with disabilities. Everyday inclusive Web…

  6. Inclusive Education in Bosnia and Herzegovina

    ERIC Educational Resources Information Center

    Dizdarevic, Alma; Vantic-Tanjic, Medina; Nikolic, Milena

    2010-01-01

    This paper describes the different challenges faced by all members of the local community who are directly or indirectly responsible for the educational reform regarding the process of inclusion in Bosnia and Herzegovina. Yugoslavia education system is regulated in canton legislature. Each canton has its own law on preschool, elementary school,…

  7. Inclusion through Transdisciplinary Teaming (ITT). Final Report.

    ERIC Educational Resources Information Center

    Olson, Jennifer; And Others

    This final report describes the Inclusion through Transdisciplinary Teaming (ITT) project, which provided support to personnel working in schools, child care centers, and Head Start programs as they designed and provided services that included young children with disabilities and their families. During its 3 years of outreach, ITT project staff…

  8. Diversity and Inclusion in the Early Years

    ERIC Educational Resources Information Center

    Petriwskyj, A.

    2010-01-01

    The emphasis on inclusion of diverse learners presents challenges to early-years teachers, particularly those whose understandings have been framed by notions of school readiness and of special education for children with disabilities. This mixed-method study of children and teachers in early-years classes across three school sites in Australia…

  9. Negotiating the Path: Towards Diversity and Inclusion

    ERIC Educational Resources Information Center

    Mason, Letita R.

    2009-01-01

    Global survival hinges on an appreciation that the solutions to problems reside within the collective strength of diversity. However, achieving inclusion is often relegated to periodic infusions of multiculturalism into the mainstream of organizational culture. And "diversity" is quickly becoming the latest buzzword for an idea that, though…

  10. Into the Workforce: Employers' Perspectives of Inclusion

    ERIC Educational Resources Information Center

    Irvine, Angela; Lupart, Judy

    2008-01-01

    Employment is an important component to community living that allows persons with disabilities the opportunity to form new relationships and learn new skills. Individuals with disabilities have much to contribute to the work place and, if a proper "fit" is achieved, work inclusion can benefit all involved. This project provides and insight into…

  11. Citizenship Education in Turkey: Inclusive or Exclusive

    ERIC Educational Resources Information Center

    Ince, Basak

    2012-01-01

    This paper scrutinises citizenship education in Turkey from the foundation of the Turkish Republic (1923) to the present and explores the extent to which it encourages inclusive or exclusive concepts of national identity and citizenship. In Turkey, where there are citizens belonging to ethnic and religious minorities, civic education plays a…

  12. A nonlinear elasticity phantom containing spherical inclusions

    PubMed Central

    Pavan, Theo Z.; Madsen, Ernest L.; Frank, Gary R.; Jiang, Jingfeng; Carneiro, Antonio Adilton O.; Hall, Timothy J.

    2012-01-01

    The strain image contrast of some in vivo breast lesions changes with increasing applied load. This change is attributed to differences in the nonlinear elastic properties of the constituent tissues suggesting some potential to help classify breast diseases by their nonlinear elastic properties. A phantom with inclusions and long-term stability is desired to serve as a test bed for nonlinear elasticity imaging method development, testing, etc. This study reports a phantom designed to investigate nonlinear elastic properties with ultrasound elastographic techniques. The phantom contains four spherical inclusions and was manufactured from a mixture of gelatin, agar and oil. The phantom background and each of the inclusions has distinct Young’s modulus and nonlinear mechanical behavior. This phantom was subjected to large deformations (up to 20%) while scanning with ultrasound, and changes in strain image contrast and contrast-to-noise ratio (CNR) between inclusion and background, as a function of applied deformation, were investigated. The changes in contrast over a large deformation range predicted by the finite element analysis (FEA) were consistent with those experimentally observed. Therefore, the paper reports a procedure for making phantoms with predictable nonlinear behavior, based on independent measurements of the constituent materials, and shows that the resulting strain images (e.g., strain contrast) agrees with that predicted with nonlinear FEA. PMID:22772074

  13. Advances in Schoolwide Inclusive School Reform

    ERIC Educational Resources Information Center

    Sailor, Wayne

    2015-01-01

    This article highlights three significant advances in schoolwide inclusive school reform and suggests three next steps to improve educational outcomes for "all" students, particularly for students for whom typical instruction is not effective. Significant advances are as follows: (a) a multi-tiered system of support (MTSS) with embedded…

  14. Effective Inclusive Schools: Designing Successful Schoolwide Programs

    ERIC Educational Resources Information Center

    Hehir, Thomas; Katzman, Lauren I.

    2012-01-01

    This book presents lessons learned from in-depth case studies of some of our most effective inclusive public schools. The authors conclusively demonstrate that schools can educate students with mild and severe disabilities in general education classrooms by providing special education services that link to and bolster general education…

  15. Building Inclusive Communities: A Social Capital Approach

    ERIC Educational Resources Information Center

    Shaklee, Harriet; Laumatia, Laura; Luckey, Brian; Traver, Sue; Nauman, Arlinda; Tifft, Kathee; Liddil, Audrey; Hampton, Carol

    2010-01-01

    Population shifts have changed the face of many Idaho communities, but inclusive relationships among groups can build the social capital required for communities to thrive. University of Idaho Extension developed "Idaho's Journey for Diversity and Human Rights" as a hands-on traveling workshop about past and present issues of human rights and…

  16. Inclusive Science Education: Learning from Wizard

    ERIC Educational Resources Information Center

    Koomen, Michele Hollingsworth

    2016-01-01

    This case study reports on a student with special education needs in an inclusive seventh grade life science classroom using a framework of disability studies in education. Classroom data collected over 13 weeks consisted of qualitative (student and classroom observations, interviews, student work samples and video-taped classroom teaching and…

  17. "Coming out Crip" in Inclusive Education

    ERIC Educational Resources Information Center

    Erevelles, Nirmala

    2011-01-01

    Background/Context: The author argues that within inclusive education's almost obsessive focus on space, there is a tendency to ignore the ideological assumptions that undergird the curricular and extracurricular practices in schools that serve to construct certain student subjectivities as deviant, disturbing, and dangerous, thereby justifying…

  18. Inclusive Schooling: Are We There yet?

    ERIC Educational Resources Information Center

    Causton, Julie; Theoharis, George

    2013-01-01

    Today, when trying to find a way to an unfamiliar destination, many rely on global positioning systems, or GPS technology. "Recalibrating" and "Whenever possible make a legal U-turn" are now ubiquitous phrases in the audio backdrop to many car trips. One can think about modern-day inclusive education in similar terms. The programming decisions…

  19. Making Campuses More Inclusive of Transgender Students

    ERIC Educational Resources Information Center

    Beemyn, Brett Genny

    2005-01-01

    This article examines a number of areas of campus life where transgender students experience discrimination because of gender-exclusive policies and practices: health care, residence halls, bathrooms, locker rooms, records and documents, public inclusion, and programming, training, and support. The specific obstacles faced by transgender students…

  20. Public Policies that Help Foster Social Inclusion

    ERIC Educational Resources Information Center

    Cheung, Chau-kiu

    2013-01-01

    Public policies can be effective in raising people's social inclusion as intended only reasonably through their implementation. With respect to the implementation perspective, this study examines the effectiveness of eight policies as perceived to implement in Hong Kong, China. The study employs data collected from 1,109 Chinese adults randomly…

  1. The Role of Interpreters in Inclusive Classrooms.

    ERIC Educational Resources Information Center

    Antia, Shirin D.; Kreimeyer, Kathryn H.

    2001-01-01

    A qualitative 3-year case study followed three deaf interpreters in an inclusive school. Results of interviews indicated that, in addition to sign interpreting, the interpreters clarified teacher directions, facilitated peer interaction, tutored the deaf children, and kept teachers and special educators informed of the deaf children's progress.…

  2. Inclusive Schooling: Is It a Success?

    ERIC Educational Resources Information Center

    Nahlous-Ismail, Nada

    2010-01-01

    One of the aims of each Australian States and Territory Departments of Education and Training is to create a world-class inclusive strategy in schools across the nation. They each see the need to raise awareness, support and change societal expectations for students with Special Needs and Disabilities nationally. This paper aims to investigate the…

  3. Inclusive High Schools: Learning from Contemporary Classrooms.

    ERIC Educational Resources Information Center

    Fisher, Douglas, Ed.; Sax, Caren, Ed.; Pumpian, Ian, Ed.

    Addressing both processes and outcomes, this book provides a framework for developing inclusive high schools, illustrated by detailed accounts of high schools that have struggled, strategized, and ultimately achieved success. Themes discussed include building crucial school-based relationships, developing support strategies, communicating…

  4. Integration and Segregation: Inclusion and Exclusion.

    ERIC Educational Resources Information Center

    Emanuelsson, Ingemar

    In considering what to do with the normally existing diversity in a group of children coming to a school intended for all, the concepts of integration, segregation, inclusion, and exclusion must be considered as characteristics of school aims, organization, and work. Questions related to these concepts are particularly pertinent in a discussion of…

  5. SIGN: Science, Inclusion and Growth in Norfolk.

    ERIC Educational Resources Information Center

    Lefever, David; Symonds, Lynne

    2000-01-01

    Science, Inclusion, and Growth in Norfolk (SIGN) is a Public Understanding of Science project that seeks to use the understanding of plant and soil science to demonstrate that people with severe learning difficulties can find the scientific method of inquiry a relevant and rewarding route to self-confidence and an understanding of the events that…

  6. Changes in Preservice Teacher Attitudes toward Inclusion

    ERIC Educational Resources Information Center

    Swain, Kristine D.; Nordness, Philip D.; Leader-Janssen, Elizabeth M.

    2012-01-01

    Despite federal mandates to educate students with disabilities in the least restrictive environment, teachers continue to have mixed feelings about their own preparedness to educate students with disabilities in the general education setting. However, research has demonstrated that teachers with more positive attitudes toward inclusion are more…

  7. On the Dirt Road to Inclusion

    ERIC Educational Resources Information Center

    Wiazowski, Jaroslaw

    2012-01-01

    Inclusive education in the Republic of South Africa has been codified and written down in the form of White Papers. From the legislative point of view, the situation is clear. The reality however shows that the implementation of the law is still at its infancy. Students with visual impairments are practically confined to being educated in…

  8. Creating Inclusive Schools for All Students

    ERIC Educational Resources Information Center

    Causton-Theoharis, Julie; Theoharis, George

    2009-01-01

    Inclusion in general education and attention to belonging are the first steps toward greater achievement for all students. This must be followed by improving the core teaching and curriculum to enhance learning of all students through differentiation, and teaching to multiple modalities and learning preferences. For these changes to occur,…

  9. Inclusion in the USA: An Overview.

    ERIC Educational Resources Information Center

    Lienert, Christoph; Grosse, Susan

    2003-01-01

    Describes the inclusion of students with disabilities into general education classes in the United States, focusing on physical education and examining relevant legislation and applications to physical education. A rebuttal asserts that physical educators must "let go of historical rhetoric," suggesting that guidelines and legislation are…

  10. Numerical Simulations of Inclusion Behavior in Gas-Stirred Ladles

    NASA Astrophysics Data System (ADS)

    Lou, Wentao; Zhu, Miaoyong

    2013-06-01

    A computation fluid dynamics-population balance model (CFD-PBM) coupled model has been proposed to investigate the bubbly plume flow and inclusion behavior including growth, size distribution, and removal in gas-stirred ladles, and some new and important phenomena and mechanisms were presented. For the bubbly plume flow, a modified k- ɛ model with extra source terms to account for the bubble-induced turbulence was adopted to model the turbulence, and the bubble turbulent dispersion force was taken into account to predict gas volume fraction distribution in the turbulent gas-stirred system. For inclusion behavior, the phenomena of inclusions turbulent random motion, bubbles wake, and slag eye forming on the molten steel surface were considered. In addition, the multiple mechanisms both that promote inclusion growth due to inclusion-inclusion collision caused by turbulent random motion, shear rate in turbulent eddy, and difference inclusion Stokes velocities, and the mechanisms that promote inclusion removal due to bubble-inclusion turbulence random collision, bubble-inclusion turbulent shear collision, bubble-inclusion buoyancy collision, inclusion own floatation near slag-metal interface, bubble wake capture, and wall adhesion were investigated. The importance of different mechanisms and total inclusion removal ratio under different conditions, and the distribution of inclusion number densities in ladle, were discussed and clarified. The results show that at a low gas flow rate, the inclusion growth is mainly attributed to both turbulent shear collision and Stokes collision, which is notably affected by the Stokes collision efficiency, and the inclusion removal is mainly attributed to the bubble-inclusion buoyancy collision and inclusion own floatation near slag-metal interface. At a higher gas flow rate, the inclusions appear as turbulence random motion in bubbly plume zone, and both the inclusion-inclusion and inclusion-bubble turbulent random collisions become

  11. Diagenetic palaeotemperatures from aqueous fluid inclusions: re- equilibration of inclusions in carbonate cements by burial heating.

    USGS Publications Warehouse

    Burruss, R.C.

    1987-01-01

    Calculations based on the observed behaviour of inclusions in fluorite under external confining P allows prediction of the T and depths of burial necessary to initiate re-equilibration of aqueous inclusions in the common size range 40-4 mu m. Heating of 20-60oC over the initial trapping T may cause errors of 10-20oC in the homogenization T. This suggests that re-equilibration may cause aqueous inclusions in carbonates to yield a poor record of their low-T history, but a useful record of the maximum T experienced by the host rock. Previous work suggests that inclusions containing petroleum fluids will be less susceptible to re-equilibration.This and the following six abstracts represent papers presented at a joint meeting of the Applied Mineralogy Group of the Mineralogical Society and the Petroleum Group of the Geological Society held in Newcastle upon Tyne in April 1986.-R.A.H.

  12. Interaction between a crack and a soft inclusion

    NASA Technical Reports Server (NTRS)

    Xue-Hui, L.; Erdogan, F.

    1985-01-01

    With the application to weld defects in mind, the interaction problem between a planar-crack and a flat inclusion in an elastic solid is considered. The elastic inclusion is assumed to be sufficiently thin so that the thickness distribution of the stresses in the inclusion may be neglected. The problem is reduced to a system of four integral equations having Cauchy-type dominant kernels. The stress intensity factors are calculated and tabulated for various crack-inclusion geometries and the inclusion to matrix modulus ratios, and for general homogeneous loadiong conditions away from the crack-inclusion region.

  13. Addition of Titanium Oxide Inclusions into Liquid Steel to Control Nonmetallic Inclusions

    NASA Astrophysics Data System (ADS)

    Kiviö, Miia; Holappa, Lauri

    2012-04-01

    Titanium oxide inclusions in steel are well known to inhibit grain growth and act as nucleation sites for acicular ferrite because of absorbing manganese from the surrounding steel resulting in a manganese depleted zone around the inclusion. In this article, the inclusions resulting from TiO2 additions to low-alloyed C-Mn-Cr steel were studied. Different types of TiO2 containing materials were added to liquid steel before or during casting to get small titanium-oxide-rich inclusions in steel. The main goals were to find out what happens to TiO2 in liquid steel after addition and during cooling and to study further what type of inclusions are formed in the steel as a result of the TiO2 addition. Based on the thermodynamic calculations and the results of scanning electron microscope (SEM)-energy dispersive spectroscope (EDS) and SEM-electron backscatter diffraction (EBSD) analysis, TiO2 is first reduced to Ti3O5 in liquid steel at high temperatures and then to Ti2O3 during cooling at around 1573 K (1300 °C). Both reactions liberate oxygen, which reacts with Ti, Mn, and Al forming complex Ti2O3-rich inclusions. The results also show that TiO2 additions result in more TiOx + MnO inclusions compared with experiments with Ti addition and that the absolute amount of manganese present in the inclusions is much higher in experiments with TiO2 addition than in experiments with Ti additions.

  14. Origins of Majoritic Inclusions in Diamond

    NASA Astrophysics Data System (ADS)

    Kiseeva, K.; Wood, B. J.; Ghosh, S. K.; Stachel, T.

    2015-12-01

    Mineral inclusions in diamonds are the only available samples from the transition zone and the lower mantle. The dominant type of inclusions for the range of transition zone (410-660 km) pressures is majoritic garnet, a high-pressure Si-rich tetragonal garnet which crystallises when pyroxene breaks down and dissolves in the garnet structure. Two majoritic garnet endmembers: Na2MgSi5O12 and Mg4Si4O12 can be distinguished for eclogitic and peridotitic parageneses, respectively. In our recent study [1] we used these idealised substitutions to show that the majority of majoritic garnets reported in the literature belong to neither eclogitic nor peridotitic lithologies and rather crystallised from a wide range of intermediate compositions, referred to as pyroxenites [1]. Here we elaborate on the origin and composition of the pyroxenite lithology. According to Si geobarometry most majoritic garnet inclusions formed at mantle transition zone pressures, predominantly within the stability field of clinopyroxene + garnet. Using experimental partition coefficients for Na, Al, Mg and Fe between garnet and clinopyroxene, we have calculated the compositions of clinopyroxene in equilibrium with majoritic garnet, which allows us to estimate the locus of possible bulk rock compositions. These lie in the field of upper mantle pyroxenites as defined by Hirschmann and Stolper [2]. We also find that occasional clinopyroxene inclusions in diamond actually coexisting with majoritic garnet inclusions are all close in composition to those predicted by our study. Additionally, we show experimentally that the pyroxenite-diamond association is probably a consequence of the interaction between basaltic and peridotitic compositions in the presence of carbonate melt and that layering of pyroxenites is a natural consequence of this interaction. Reduction of carbonate to carbon at high pressures is responsible for the genetic connection between pyroxenite and diamond and the abundance of

  15. Paint chip poisoning of Laysan albatross at Midway Atoll (Pacific Ocean)

    USGS Publications Warehouse

    Sileo, L.; Fefer, S.I.

    1987-01-01

    Epizootic mortality occurred in Laysan albatross (Diomedea immutabilis) fledgings at Midway Atoll in 1983. Heavy metal toxicity from ingestion of weathered paint chips was one of the causes. Sick albatrosses were unable to retract their wings, causing a 'droop-wing' appearance. Five normal and 12 droop-winged fledglings were captured, killed, and examined. Paint chips found in the proventriculus of the affected fledglings contained up to 144,000 ppm lead. Blood, liver, and kidney concentrations of lead in affected birds were higher than in normal fledglings, and acid-fast intranuclear inclusion bodies were present in the kidneys. Degenerative lesions were present in the myelin of some brachial nerves. Weathered paint samples collected from 12 buildings contained up to 247,250 ppm lead and 101 ppm mercury. Lead poisoning was diagnosed in 10 of the droop-winged albatrosses and was one of the causes of morbidity. Mercury toxicosis and plastic impaction were other possible causes.

  16. Toxic lead exposure in the urban rock dove

    SciTech Connect

    DeMent, S.H.; Chisolm, J.J. Jr.; Eckhaus, M.A.; Strandberg, J.D.

    1987-04-01

    Thirteen adult urban rock doves (Columba livia), 12 captured alive and one found dead, were studied from the Baltimore zoo. The mean concentration of lead in the blood for the 12 live birds was 184.5 +/- 531.2 (range 10.5-1,870 micrograms/dl). Three of the 13 birds with high measured blood and tissue lead concentrations were found at necropsy with lead shot pellets in their gizzards. Correlations were not found between concentrations of lead in the blood and body weight or hematocrit. Conversely, high correlations were noted between concentrations of lead in the blood and measured liver and kidney concentrations (r = 0.946, P less than 0.01; r = 0.993, P less than 0.01, respectively). Numbers of intranuclear acid-fast inclusions per 10 consecutive fields (100x oil immersion lens) correlated well with measured kidney lead concentrations (r = 0.990, P less than 0.001).

  17. Inclusive science education: learning from Wizard

    NASA Astrophysics Data System (ADS)

    Koomen, Michele Hollingsworth

    2016-06-01

    This case study reports on a student with special education needs in an inclusive seventh grade life science classroom using a framework of disability studies in education. Classroom data collected over 13 weeks consisted of qualitative (student and classroom observations, interviews, student work samples and video-taped classroom teaching and learning record using CETP-COP) methods. Three key findings emerged in the analysis and synthesis of the data: (1) The learning experiences in science for Wizard are marked by a dichotomy straddled between autonomy ["Sometimes I do" (get it)] and dependence ["Sometimes I don't (get it)], (2) the process of learning is fragmented for Wizard because it is underscored by an emerging disciplinary literacy, (3) the nature of the inclusion is fragile and functional. Implications for classroom practices that support students with learning disabilities include focusing on student strengths, intentional use of disciplinary literacy strategies, and opportunities for eliciting student voice in decision making.

  18. Inclusion for toddlers with autism spectrum disorders

    PubMed Central

    STAHMER, AUBYN C.; AKSHOOMOFF, NATACHA; CUNNINGHAM, ALLISON B.

    2014-01-01

    The present quasi-experimental study examines the outcomes for a group of 102 children diagnosed with an autism spectrum disorder at age 2 who attended an inclusive toddler program (described by Stahmer and Ingersoll, 2004) until age 3. Outcomes on standardized developmental assessments indicate significant improvement, with large effect sizes, in developmental level, adaptive behavior and communication. Thirty-one of the children (31%) were functioning in the typically developing range when they exited the program at age 3, after an average of 8 months of intervention. Predictors of positive outcomes included length of time in the program, level of words and gestures use at entry and higher externalizing and lower internalizing behavior CBCL scores at entry. Implications for serving toddlers with autism in inclusive settings and suggestions for future research directions are discussed. PMID:21486899

  19. Inclusive Planning: Paramount in Today's Norway.

    PubMed

    Nohr, Trine; Langset, Eli Kristin

    2016-01-01

    Democratic rights are granted by its nations legislation and systems, but needs enforcement by its institutions to be effective. This also relates to Universal Design. The refugee crisis in Europe raises questions as to how planning in the societies can be designed and implemented to include the new groups of the population. The Norwegian Planning and Building Act (PBA) put weight on the individual's or a group's right to influence public assessment and decision making processes. In this article a case from the Veitvet-Sletteløkka area in the ward of Bjerke, Oslo, is presented to show how these principles can be put into practice. The case clearly demonstrates how the presence of representatives from the ward and planning authority built trust to the various parts of the local community by a consistent and inclusive approach. Also, to further enhance inclusion and effectiveness in planning, the case illustrates the need for adapting new technologies, communication modes and perspectives. PMID:27534305

  20. Input on NIH Toolbox inclusion criteria

    PubMed Central

    Victorson, David; Debb, Scott M.; Gershon, Richard C.

    2013-01-01

    Objective: The NIH Toolbox is intended to be responsive to the needs of investigators evaluating neurologic and behavioral function in diverse settings. Early phases of the project involved gathering information and input from potential end users. Methods: Information was collected through literature and instrument database reviews, requests for information, consensus meetings, and expert interviews and integrated into the NIH Toolbox development process in an iterative manner. Results: Criteria for instrument inclusion, subdomains to be assessed, and preferences regarding instrument cost and length were obtained. Existing measures suitable for inclusion in the NIH Toolbox and areas requiring new measure development were identified. Conclusion: The NIH Toolbox was developed with explicit input from potential end users regarding many of its key features. PMID:23479548

  1. Formalizing Darwinism and inclusive fitness theory.

    PubMed

    Grafen, Alan

    2009-11-12

    Inclusive fitness maximization is a basic building block for biological contributions to any theory of the evolution of society. There is a view in mathematical population genetics that nothing is caused to be maximized in the process of natural selection, but this is explained as arising from a misunderstanding about the meaning of fitness maximization. Current theoretical work on inclusive fitness is discussed, with emphasis on the author's 'formal Darwinism project'. Generally, favourable conclusions are drawn about the validity of assuming fitness maximization, but the need for continuing work is emphasized, along with the possibility that substantive exceptions may be uncovered. The formal Darwinism project aims more ambitiously to represent in a formal mathematical framework the central point of Darwin's Origin of Species, that the mechanical processes of inheritance and reproduction can give rise to the appearance of design, and it is a fitting ambition in Darwin's bicentenary year to capture his most profound discovery in the lingua franca of science. PMID:19805422

  2. Inclusive jet production at the Tevatron

    SciTech Connect

    Norniella, Olga; /Barcelona, IFAE

    2006-08-01

    Preliminary results on inclusive jet production in proton-antiproton collisions at {radical}s = 1.96 TeV based on 1 fb{sup -1} of CDF Run II data are presented. Measurements are preformed using different jet algorithms in a wide range of jet transverse momentum and jet rapidity. The measured cross sections are compared to next-to-leading order perturbative QCD calculations

  3. Optimal Control of Evolution Mixed Variational Inclusions

    SciTech Connect

    Alduncin, Gonzalo

    2013-12-15

    Optimal control problems of primal and dual evolution mixed variational inclusions, in reflexive Banach spaces, are studied. The solvability analysis of the mixed state systems is established via duality principles. The optimality analysis is performed in terms of perturbation conjugate duality methods, and proximation penalty-duality algorithms to mixed optimality conditions are further presented. Applications to nonlinear diffusion constrained problems as well as quasistatic elastoviscoplastic bilateral contact problems exemplify the theory.

  4. Inclusive jet cross section at D0

    SciTech Connect

    Bhattacharjee, M.

    1996-09-01

    Preliminary measurement of the central ({vert_bar}{eta}{vert_bar} {<=} 0.5) inclusive jet cross sections for jet cone sizes of 1.0, 0.7, and 0.5 at D{null} based on the 1992-1993 (13.7 {ital pb}{sup -1}) and 1994-1995 (90 {ital pb}{sup -1}) data samples are presented. Comparisons to Next-to-Leading Order (NLO) Quantum Chromodynamics (QCD) calculations are made.

  5. Bursting the bubble of melt inclusions

    USGS Publications Warehouse

    Lowenstern, Jacob B.

    2015-01-01

    Most silicate melt inclusions (MI) contain bubbles, whose significance has been alternately calculated, pondered, and ignored, but rarely if ever directly explored. Moore et al. (2015) analyze the bubbles, as well as their host glasses, and conclude that they often hold the preponderance of CO2 in the MI. Their findings entreat future researchers to account for the presence of bubbles in MI when calculating volatile budgets, saturation pressures, and eruptive flux.

  6. Inclusive jet cross section measurement at CDF

    SciTech Connect

    Pagliarone, C.

    1996-08-01

    The CDF Collaboration has measured the inclusive jet cross section using 1992-93 collider data at 1.8 TeV. The CDF measurement is in very good agreement with NLO QCD predictions for transverse energies (E{sub T}) below 200 GeV. However, it is systematically higher than NLO QCD predictions for E{sub T} above 200 GeV.

  7. Fluid inclusions in stony meteorites--a cautionary note.

    PubMed

    Rudnick, R L; Ashwal, L D; Henry, D J; Gibson, E K; Roedder, E; Belkin, H E; Colucci, M T

    1985-02-15

    Newly discovered fluid inclusions in thin sections of Bjurbole chondrules, shergottite EETA79001, lunar meteorite ALHA81005, and Apollo 16 glasses possess physical properties similar to those fluid inclusions found in thin sections of five stony meteorites recently described by Warner et al. (1983). The distribution and physical properties of these new fluid inclusions indicate they may be artifacts of thin section preparation; we suggest that saw coolant was sucked into vacuum vesicles in glasses and minerals through submicroscopic fractures produced during sawing. The similarities between these fluid inclusions and fluid inclusions previously described by Warner et al. (1983) lead us to conclude that many of the fluid inclusions reported earlier may be artifacts. Consequently, the origin of any fluid inclusions observed in thin sections of extraterrestrial materials must be interpreted with caution. The most probable true extraterrestrial fluid inclusions are those that have been observed in grains prepared without exposure to liquids of any kind. PMID:11542002

  8. Silicate Inclusions in the Kodaikanal IIE Iron Meteorite

    NASA Astrophysics Data System (ADS)

    Kurat, G.; Varela, M. E.; Zinner, E.

    2005-03-01

    II-E iron meteorites are particularly interesting because they contain an exotic zoo of silicate inclusions including some chemically strongly fractionated ones. Here we present preliminary findings in our study of Kodaikanal silicate inclusions.

  9. CHARACTERIZATION OF THE PARASPORAL INCLUSION OF BACILLUS THURINGIENSIS VAR. KYUSHUENSIS

    EPA Science Inventory

    Bacillus thuringiensis var. kyushuensis synthesizes an irregularly shaped parasporal inclusion during sporulation. lectron microscopy revealed that the inclusions are composed of a relatively homogeneous appearing center surrounded by a thick, electron dense coating. urified incl...

  10. 40 CFR 35.533 - Programs eligible for inclusion.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Programs eligible for inclusion. 35.533... § 35.533 Programs eligible for inclusion. (a) Eligible programs. Except as provided in paragraph (b) of this section, the environmental programs eligible for inclusion in a Performance Partnership Grant...

  11. 40 CFR 35.133 - Programs eligible for inclusion.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Programs eligible for inclusion. 35.133... Programs eligible for inclusion. (a) Eligible programs. Except as provided in paragraph (b) of this section, the environmental programs eligible, in accordance with appropriation acts, for inclusion in...

  12. Inclusive Education, Exclusion and Difficult Difference: A Call for Humanity?

    ERIC Educational Resources Information Center

    Rogers, Chrissie

    2012-01-01

    This article presents the author's review of three books: (1) "The irregular school: exclusion, schooling and inclusive education," by Roger Slee; (2) "Confronting obstacles to inclusion: international responses to developing inclusive education," edited by Richard Rose; and (3) ""Hanging in with the kids" in tough times: engagement in contexts of…

  13. Inclusion: The Pros and Cons--A Critical Review

    ERIC Educational Resources Information Center

    Savich, Carl

    2008-01-01

    The purpose of this paper was to review, analyze, and critique the pros and cons, the advantages and disadvantages, of inclusion. The methodology consisted in analyzing and comparing research findings on the benefits and costs of inclusion. Federal legislation and regulations on inclusion were examined, analyzed, and discussed. The results showed…

  14. Preparing Teachers for Inclusive Education in Latin America

    ERIC Educational Resources Information Center

    Vaillant, Denise

    2011-01-01

    This article analyzes the current challenges facing inclusive education in Latin America and explores some possible solutions. The author suggests that teachers play a key role in providing education that is inclusive for all. In Latin America, today, however, inclusive education often does not respond to the needs of children and young people,…

  15. Barriers that Prevent the Achievement of Inclusive Democratic Education

    ERIC Educational Resources Information Center

    Garcia-Huidobro, Juan Eduardo; Corvalan, Javier

    2009-01-01

    Inclusive education inherently involves the inclusion of all citizens in a democratic society. Based on this view, questions emerge with respect to equality and integration in educational systems. Although inclusion should be viewed as a requirement in a democratic society, along with the integration in schools of students from different social…

  16. Epistemological Beliefs and Attitudes toward Inclusion in Preservice Teachers

    ERIC Educational Resources Information Center

    Silverman, Jenzi C.

    2007-01-01

    Previous investigations suggest that in addition to positive attitudes toward inclusion, high-level beliefs about knowledge and learning (i.e., epistemological beliefs) are essential for all teachers of students with disabilities in inclusive settings. This study examined the attitudes toward inclusion and epistemological belief status of 71…

  17. Teacher Preparation for Inclusive Education: Increasing Knowledge but Raising Concerns

    ERIC Educational Resources Information Center

    Forlin, Chris; Chambers, Dianne

    2011-01-01

    The role of the generalist teacher is now affirmed as being an important component in the success or otherwise of inclusive education practice. Issues about the effectiveness of teacher preparation for working in inclusive classes have arisen. An evaluation of pre-service teachers' perceptions regarding their preparedness for inclusion had some…

  18. The Czech Way of Inclusion through an Experiential Education Framework

    ERIC Educational Resources Information Center

    Kudlacek, Martin; Bocarro, Jason; Jirasek, Ivo; Hanus, Radek

    2009-01-01

    The purpose of this article is to present the development of inclusive experiential education courses in the Czech Republic. The inclusion of people with disabilities (PWD) in recreation, sport, and education has become more prevalent in Czech society. This article describes the conceptual meaning of the term inclusion from both a historical and…

  19. Inclusion and Guilt: The Emotional Fallout for Teachers

    ERIC Educational Resources Information Center

    Macmillan, Robert; Meyer, Matthew J.

    2006-01-01

    The principle of inclusion of children with exceptionalities is accepted by teachers, but the practice of inclusion is problematic, particularly at the secondary level. In a study of inclusion and the impact of budgetary constraints in Nova Scotia, teachers reported that they had difficulty meeting the needs of all students within their classroom…

  20. Teacher Attitude towards Inclusion Practices and Special Needs Students

    ERIC Educational Resources Information Center

    Ross-Hill, Rorie

    2009-01-01

    This paper investigates the varying attitudes of regular (mainstream) education teachers towards the implementation of inclusion in elementary and secondary school classrooms. This paper tries to take into account the need for a better understanding of teacher attitude towards inclusion and how the inclusive environment can be improved. The…

  1. Leadership Strategies for Successful Schoolwide Inclusion: The STAR Approach

    ERIC Educational Resources Information Center

    Munk, Dennis D.; Dempsey, Thomas L.

    2010-01-01

    Effective, "schoolwide" inclusion ensures the best outcomes for all students--but how can school teams knock down the barriers to inclusion and make sure it's happening across all classrooms? This concise book gives principals and other school leaders the solution they've been waiting for: a clear framework for leading inclusion efforts,…

  2. Embracing Diversity: Toolkit for Creating Inclusive Learning-Friendly Environments

    ERIC Educational Resources Information Center

    Harris, Ray; Miske, Shirley; Attig, George

    2004-01-01

    An inclusive, learning-friendly environment (ILFE) welcomes, nurtures, and educates all children regardless of their gender, physical, intellectual, socio-economic, emotional, linguistic and other characteristics. "Inclusive" in the school setting generally refers to the inclusion or children with disabilities into regular classrooms designed for…

  3. Pre-Service Educators' Attitudes towards Inclusive Education

    ERIC Educational Resources Information Center

    Mdikana, Andile; Ntshangase, Sibusiso; Mayekiso, Tokozile

    2007-01-01

    The inclusion of learners with special educational needs in general education is becoming more prevalent. As a result various special education researchers have begun to examine the success of inclusion, as well as the attitudes and beliefs of general educators towards the inclusion of learners with disabilities in the general education classroom.…

  4. Inclusive Education: Practical Implementation of the Least Restrictive Environment.

    ERIC Educational Resources Information Center

    Power-deFur, Lissa A.; Orelove, Fred P.

    The 19 chapters of this book address theoretical and practical aspects of the development and implementation of inclusive education programs. Chapter titles and authors are: (1) "Inclusive Education: The Past, Preset, and Future" (Lissa A. Power-deFur and Fred P. Orelove); (2) "Inclusion and School Restructuring: Meeting the Needs of All Children"…

  5. Does Inclusion Cost More? The Cost of Special Education.

    ERIC Educational Resources Information Center

    Mawdsley, Ralph D.

    1995-01-01

    Whether inclusion will produce resource economies for school districts is difficult to determine. Districts that have developed inclusive models have reported mixed results. There appear to be no savings in personnel costs, although some overall reduction in transportation expenditure has occurred. Inclusion demands a more fluid approach to…

  6. Preschool Teachers' Knowledge Levels about Inclusion

    ERIC Educational Resources Information Center

    Sucuoglu, Bülbin; Bakkaloglu, Hatice; Iscen Karasu, Fadime; Demir, Seyda; Akalin, Selma

    2014-01-01

    The purpose of this study is to develop the Inclusion Knowledge Test (IKT) for assessing preschool teachers' knowledge of inclusive practices and to examine its psychometric characteristics. To achieve this purpose, the researchers wrote short stories (vignettes) focusing on the various aspects of inclusive practices, such as assessing the…

  7. Statistical Trends and Developments within Inclusive Education in Turkey

    ERIC Educational Resources Information Center

    Cakiroglu, Orhan; Melekoglu, Macid Ayhan

    2014-01-01

    The education of students with special needs in an inclusive environment is becoming more widespread throughout the world. Similarly, in Turkey, the inclusion of students with disabilities has also improved. However, current statistical trends and developments within inclusive education are not well known. The purpose of this study is to provide a…

  8. The Teacher Attitudes Toward Inclusion Scale (TATIS) Technical Report

    ERIC Educational Resources Information Center

    Cullen, Joseph P.; Gregory, Jess L.; Noto, Lori A.

    2010-01-01

    Teacher attitudes toward the inclusion of children with disabilities into general education classrooms have been found to be strong predictors of the success of efforts to create inclusive learning communities. Specifically, research has shown that when teachers have positive mindsets toward inclusion, they more readily adapt their teaching…

  9. Building Inclusive School and Pre-School Communities.

    ERIC Educational Resources Information Center

    Kendrick, Martie; Labas, Linda

    This paper provides an overview of the Maine Department of Education's "Foundations of Inclusive Education," a guide for early childhood professionals, families, and educators on implementing inclusive education for school and preschool children. A basic premise of the guide is that inclusive education is not a separate initiative for children…

  10. Variables Affecting Teachers' Attitudes towards Inclusive Education in Bangladesh

    ERIC Educational Resources Information Center

    Ahmmed, Masud; Sharma, Umesh; Deppeler, Joanne

    2012-01-01

    Inclusive education is a worldwide reform strategy intended to include students with different abilities in mainstream regular schools. Evidence from previous research shows that success in implementing effective inclusive teaching practices in the school is contingent on teachers' positive attitudes towards inclusive education. This study was…

  11. Trekking Back to Mainstream for Inclusive Education, Is It There?

    ERIC Educational Resources Information Center

    Kalenga, Rosemary Chimbala; Fourie, Elsa

    2012-01-01

    This paper explores the ecosystemic management strategies for inclusive schools due to challenges faced by the schools in the mainstream school where learners from the specialised institutions are referred back to mainstream for inclusive education. Ecosystemic perspective on inclusive education, ecological theories and systems theories underpin…

  12. Leadership for All Students: Planning for More Inclusive School Practices

    ERIC Educational Resources Information Center

    Black, William R.; Simon, Marsha D.

    2014-01-01

    Educational policies and leadership practice has evolved to support efforts for inclusive education for students with disabilities. This article focuses on how leaders support and develop inclusive practices for students with disability through engaging institutional norms and inertia; developing inclusive practice as a planned organization-wide…

  13. Challenges of the Secondary School Context for Inclusive Teaching

    ERIC Educational Resources Information Center

    Pearce, Michelle; Gray, Jan; Campbell-Evans, Glenda

    2010-01-01

    Senate and State Government reviews into inclusion in Australian schools during the last two decades have revealed that the inclusion of students with disabilities in schools has proved challenging. A qualitative study involving interviews with 50 leaders in inclusive education suggest that currently the secondary school context is a barrier to…

  14. Inclusion in Viet Nam: More than a Decade of Implementation.

    ERIC Educational Resources Information Center

    Villa, Richard A.; Tac, Le Van; Muc, Pham Minh; Ryan, Susan; Thuy, Nguyen Thi Minh; Weill, Cindy; Thousand, Jacqueline S.

    2003-01-01

    This article traces the evolution of special education policies and services and the introduction of inclusive education as a service delivery model in Viet Nam. The impact of a series of inclusion projects and resultant goals of the Ministry of Education and Training to expand inclusive education are described. (Contains 8 references.) (Author/CR)

  15. Modelling Inclusive Special Needs Education: Insights from Dutch Secondary Schools

    ERIC Educational Resources Information Center

    Van der Bij, T.; Geijsel, F. P.; Garst, G. J. A.; Ten Dam, G. T. M.

    2016-01-01

    Inclusive special needs education is prominent on the international education agenda. Research on the characteristics of inclusive education for students with special needs and schools providing this is scarce, however. Our aim in the present study was therefore to further theory-building with regard to inclusive special needs education. On the…

  16. Examining Teachers' Concerns and Attitudes to Inclusive Education in Ghana

    ERIC Educational Resources Information Center

    Agbenyega, Joseph

    2007-01-01

    This paper reports on a study that examined teachers' concerns and attitude toward inclusive education of students with disabilities in Ghana. A 20 item Attitudes Toward Inclusion in Africa Scale (ATIAS) was completed by 100 teachers from five "Inclusive Project" schools and five Non-Project coeducational basic schools in three different…

  17. Educational Inclusion in England: Origins, Perspectives and Current Directions

    ERIC Educational Resources Information Center

    Lauchlan, Fraser; Greig, Susan

    2015-01-01

    In this paper we examine different aspects of the inclusion debate, including how it has been shaped by the political context in England over the past 30 years. We then give consideration to the key argument that has dominated the inclusion agenda over the last decade: should effective inclusion be considered only as placement in mainstream school…

  18. 40 CFR 35.533 - Programs eligible for inclusion.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Programs eligible for inclusion. 35.533... § 35.533 Programs eligible for inclusion. (a) Eligible programs. Except as provided in paragraph (b) of this section, the environmental programs eligible for inclusion in a Performance Partnership Grant...

  19. A Perspective of Inclusion: Challenges for the Future

    ERIC Educational Resources Information Center

    Braunsteiner, Maria-Luise; Mariano-Lapidus, Susan

    2014-01-01

    The term, "inclusion," particularly in the educational setting, is still based on a deficit view. Perceptions of "dis"-ability create barriers to true inclusion and are often reinforced through higher education training programs. To promote inclusive values, acceptance of individual and cultural differences must be included in…

  20. Teacher Perspectives on Inclusive Education in Rural Alberta, Canada

    ERIC Educational Resources Information Center

    McGhie-Richmond, Donna; Irvine, Angela; Loreman, Tim; Cizman, Juna Lea; Lupart, Judy

    2013-01-01

    The results of 123 elementary-to-secondary teacher surveys and 14 in-depth qualitative interviews examining teachers' perspectives regarding inclusion in a rural school district are reported. Four features of inclusive education from the perspective of teachers are elaborated: (1) attitudes toward inclusion; (2) supportive communication and…

  1. Academic Performance of Students without Disabilities in the Inclusive Environment

    ERIC Educational Resources Information Center

    Fruth, Jason D.; Woods, Melanie N.

    2015-01-01

    This study examines the impact of inclusion on secondary students by focusing on the performance of students without disabilities in the inclusive environment compared to their performance in a segregated environment. Many studies exist demonstrating the positive impact of the inclusive environment on the performance of students with disabilities.…

  2. Cumberland Falls chondritic inclusions: III. Consortium study of relationship to inclusions in Allan Hills 78113 aubrite

    SciTech Connect

    Lipschutz, M.E.; Verkouteren, R.M. ); Sears, D.W.G.; Hasan, F.A. ); Prinz, M.; Weisberg, M.K.; Nehru, C.E.; Delaney, J.S. ); Grossman, L.; Boily, M. )

    1988-07-01

    The authors describe the mineralogy and report contents of Ag, Au, Bi, Cd, Co, Cs, Ga, In, Rb, Sb, Se, Te, Tl, U and Zn determined by RNAA in three primitive chondritic inclusions from the ALH A78113 aubrite. Comparison of these data with those for large, petrologic type 3 chondritic clasts from the Cumberland Falls aubrite and the discovery of small clasts in it like those in ALH A78113 indicate that all constitute a single chondritic suite. They report thermoluminescence data for Cumberland Falls chondritic inclusions and achondritic host. These results, together with mineralogic, major, minor and trace element information, demonstrate that aubrite inclusions represent a different sort of type 3 chondrite, not an LL3 chondrite altered during equilibration with aubrite host. Instead, the aubrite inclusions represent a distinct chondrite class. These inclusions reflect nebular condensation/accretion over a broad redox range and at temperatures relatively high compared with those at which other type 3 chondrites formed. Limited metamorphism and reduction occurred during condensation/accretion, prior to incorporation into aubrite host. During the impact of the chondritic parent body with the aubrite parent body, chondrite fragments were strongly shocked and cooled rapidly. They then mixed with aubrite host, possibly in a regolith, so that these aubrites now represent impact breccias.

  3. Building Inclusion from the Ground up: A Review of Whole School Re-Culturing Programmes for Sustaining Inclusive Change

    ERIC Educational Resources Information Center

    McMaster, Christopher

    2013-01-01

    This paper suggests that whole school re-culturing programmes can potentially assist in the creation of more inclusive value orientated schools. The relationship between school culture and successful inclusion has been demonstrated in the literature. Furthermore, the structure of whole school programmes in inculcating inclusive values and…

  4. Junction problems for thin inclusions in elastic bodies

    NASA Astrophysics Data System (ADS)

    Khludnev, A. M.

    2016-06-01

    Equilibrium problems for a 2D elastic bodies with thin Euler-Bernoulli and Timoshenko elastic inclusions are considered. It is assumed that inclusions have a joint point, and a junction problem for these inclusions is analyzed. Existence of solutions is proved, and different equivalent formulations of problems are discussed. In particular, junction conditions at the joint point are found. A delamination of the elastic inclusions is also assumed. In this case, inequality type boundary conditions are imposed at the crack faces to prevent a mutual penetration between crack faces. A convergence to infinity of a rigidity parameter of the elastic inclusions is investigated. Limit problems are analyzed.

  5. Cumberland Falls chondritic inclusions. III - Consortium study of relationship to inclusions in Allan Hills 78113 aubrite

    NASA Technical Reports Server (NTRS)

    Lipschutz, Michael E.; Verkouteren, R. Michael; Sears, Derek W. G.; Hasan, Fouad A.; Prinz, Martin

    1988-01-01

    The contents of Ag, Au, Bi, Cd, Co, Cs, Ga, In, Rb, Sb, Se, Te, Tl, U, and Zn in large chondritic clasts from the Cumbersand Falls aubrite were determined by radiochemical neutron activation analysis, and the results, together with the results of a mineralogical investigation, were compared with respective data obtained for three primitive inclusions from the ALH A78113 aubrite. The results indicated that the clasts from both aubrite sources constitute a single chondritic suite. The analyses data, together with the results of thermoluminescence data for Cumberland Falls chondritic inclusions and achondritic host, indicate that inclusions in Cumberland Falls and in ALH A78113 aubrite represent a primitive chondrite sample suite whose properties were established during primary nebular accretion and condensation over a broad redox range.

  6. Recent HERMES results from inclusive and semi-inclusive hadron production

    NASA Astrophysics Data System (ADS)

    Van Hulse, Charlotte

    2015-01-01

    Hermes collected a wealth of data using the 27.6 GeV polarized Hera lepton beam and various pure, polarized and unpolarized, gaseous targets. This unique data set opens the door to various measurements sensitive to the multi-dimensional structure of the nucleon. Among them are two-hadron production in semi-inclusive deep-inelastic scattering on a transversely polarized target, providing access to different transverse-momentum-dependent distribution and fragmentation functions in a way complementary to single-hadron production. Also transverse-target single-spin asymmetries in inclusive electroproduction of charged pions and kaons have been recently extracted, complementing data from proton-proton collisions, where large, so far unexplained, asymmetries have been observed. From inclusive measurements on various nuclear targets, the Λ polarization is extracted, also here complementing measurements in proton-proton collisions.

  7. Silicate-melt inclusions in magmatic rocks: applications to petrology

    NASA Astrophysics Data System (ADS)

    Frezzotti, Maria-Luce

    2001-01-01

    Silicate-melt inclusions in igneous rocks provide important information on the composition and evolution of magmatic systems. Such inclusions represent accidentally trapped silicate melt (±immiscible H 2O and/or CO 2 fluids) that allow one to follow the evolution of magmas through snapshots, corresponding to specific evolution steps. This information is available on condition that they remained isolated from the enclosing magma after their entrapment. The following steps of investigation are discussed: (a) detailed petrographic studies to characterise silicate-melt inclusion primary characters and posttrapping evolution, including melt crystallisation; (b) high temperature studies to rehomogenise the inclusion content and select chemically representative inclusions: chemical compositions should be compared to relevant phase diagrams. Silicate-melt inclusion studies allow us to concentrate on specific topics; inclusion studies in early crystallising phases allow the characterisation of primary magmas, while in more differentiated rocks, they unravel the subsequent chemical evolution. The distribution of volatile species (i.e., H 2O, CO 2, S, Cl) in inclusion glass can provide information on the degassing processes and on recycling of subducted material. In intrusive rocks, silicate melt inclusions may preserve direct evidence of magmatic stage evolution (e.g., immiscibility phenomena). Melt inclusions in mantle xenoliths indicate that high-silica melts can coexist with mantle peridotites and give information on the presence of carbonate melt within the upper mantle. Thus, combining silicate-melt inclusion data with conventional petrological and geochemical information and experimental petrology can increase our ability to model magmatic processes.

  8. Quantitative analysis of inclusion distributions in hot pressed silicon carbide

    SciTech Connect

    Michael Paul Bakas

    2012-12-01

    ABSTRACT Depth of penetration measurements in hot pressed SiC have exhibited significant variability that may be influenced by microstructural defects. To obtain a better understanding regarding the role of microstructural defects under highly dynamic conditions; fragments of hot pressed SiC plates subjected to impact tests were examined. Two types of inclusion defects were identified, carbonaceous and an aluminum-iron-oxide phase. A disproportionate number of large inclusions were found on the rubble, indicating that the inclusion defects were a part of the fragmentation process. Distribution functions were plotted to compare the inclusion populations. Fragments from the superior performing sample had an inclusion population consisting of more numerous but smaller inclusions. One possible explanation for this result is that the superior sample withstood a greater stress before failure, causing a greater number of smaller inclusions to participate in fragmentation than in the weaker sample.

  9. An overview on current fluid-inclusion research and applications

    USGS Publications Warehouse

    Chi, G.; Chou, I.-Ming; Lu, H.-Z.

    2003-01-01

    This paper provides an overview of some of the more important developments in fluid-inclusion research and applications in recent years, including fluid-inclusion petrography, PVTX studies, and analytical techniques. In fluid-inclusion petrography, the introduction of the concept of 'fluid-inclusion assemblage' has been a major advance. In PVTX studies, the use of synthetic fluid inclusions and hydrothermal diamond-anvil cells has greatly contributed to the characterization of the phase behaviour of geologically relevant fluid systems. Various analytical methods are being developed and refined rapidly, with the Laser-Raman and LA-ICP-MS techniques being particularly useful for volatile and solute analyses, respectively. Ore deposit research has been and will continue to be the main field of application of fluid inclusions. However, fluid inclusions have been increasingly applied to other fields of earth science, especially in petroleum geology and the study of magmatic and earth interior processes.

  10. Semiconducting glasses with flux pinning inclusions

    DOEpatents

    Johnson, William L.; Poon, Siu-Joe; Duwez, Pol E.

    1981-01-01

    A series of amorphous superconducting glassy alloys containing 1% to 10% by volume of flux pinning crystalline inclusions have been found to have potentially useful properties as high field superconducting magnet materials. The alloys are prepared by splat cooling by the piston and anvil technique. The alloys have the composition (TM).sub.90-70 (M).sub.10-30 where TM is a transition metal selected from at least one metal of Groups IVB, VB, VIB, VIIB or VIIIB of the Periodic Table such as Nb, Mo, Ru, Zr, Ta, W or Re and M is at least one metalloid such as B, P, C, N, Si, Ge or Al.

  11. What can we learn from inclusive spectra

    SciTech Connect

    Nagamiya, S.

    1981-05-01

    The present experimental status on single particle inclusive measurements is described. Then, the geometrical aspect of the collision is discussed from the data of total integrated cross sections of nuclear charge or mass. The dynamical aspect of the collision, especially that for the participating region is discussed in connection with proton spectra, composite fragment spectra, pion production, ratios of ..pi../sup -//..pi../sup +/, n/p and t//sup 3/He, and production of strange particles. The spectator physics is described from the data on projectile fragments. (GHT)

  12. MINERνA charged current inclusive analysis

    SciTech Connect

    Caicedo, D. A. M.

    2015-05-15

    MINERνA is a few-GeV neutrino scattering experiment that has been taking data in the NuMI beam line at Fermilab since November 2009. The experiment will provide important inputs, both in support of neutrino oscillation searches and as a pure weak probe of the nuclear medium. For this, MINERvA employs a fine-grained detector, with an eight ton active target region composed of plastic scintillator and a suite of nuclear targets composed of helium, carbon, iron, lead and water placed upstream of the active region. We will describe the current status of the charged current inclusive analysis in plastic scintillator.

  13. Inclusion Optimization for Next Generation Steel Products

    SciTech Connect

    Dr. Sridar Seetharaman: Dr. Alan Cramb

    2006-04-06

    The project objective is to determine the conditions under which the inclusions in liquid steel can act as heterogeneous nucleants for solidification. The experimental approach consisted of measuring the undercooling of a pure iron droplet in contact with different oxides to determine which oxides promote iron solidification by providing a suitable surface for nucleation and which oxides and under which conditions the metal can be deeply undercooled. The conclusions suggest that deep undercoolings are possible at low oxygen content provided the oxygen potential is such that substrate decomposition does not occur. If the oxygen content increases the undercooling decreases.

  14. Inclusive jet production using the kt algorithm

    SciTech Connect

    Norniella, Olga; /Barcelona, IFAE

    2006-05-01

    Results on inclusive jet production using the k{sub T} algorithm in proton-antiproton collisions at {radical}s = 1.96 TeV are presented, based on 1 fb{sup -1} of CDF Run II data. The measurements are carried out for jets with p{sub T}{sup jet} > 54 GeV/c in five different jet rapidity regions up to |y{sub jet}| = 2.1. The measured cross sections are corrected to the hadron level and compared to next-to-leading order perturbative QCD predictions (NLO pQCD).

  15. Distinguishing primary and secondary inclusion assemblages in Jack Hills zircons

    NASA Astrophysics Data System (ADS)

    Bell, Elizabeth A.; Boehnke, Patrick; Hopkins-Wielicki, Michelle D.; Harrison, T. Mark

    2015-10-01

    Detrital igneous zircons from Jack Hills, Western Australia, range in age from ~ 3.0 to nearly 4.4 Ga and contain an inclusion assemblage dominated by quartz and muscovite, cited as evidence of their derivation from peraluminous granitoids. However, some phosphate inclusions in these zircons are known to be secondary from their post-depositional U-Pb ages and manifest mineralization along cracks. We undertook a survey of mineral inclusions in 4.3-3.0 Ga Jack Hills zircons with particular emphasis on their relationship to possible alteration features (e.g., cracks, disturbed internal zonation, and visual turbidity). Mineral inclusions revealed at polished surfaces show variations in modal mineralogy, mostly corresponding to their relationship with cracks. Muscovite is common both on and away from cracks, although the chemistry of muscovite inclusions shows little relationship with other potential alteration features. Inclusions filling cracks (secondary) and inclusions isolated from cracks differ in their modal mineralogy, although both suites are rich in muscovite and quartz. The higher incidence of crack-intersecting inclusions among younger zircons may reflect effects of the (generally larger) inclusion size among younger zircons. Mismatches between the isolated and crack-intersecting populations indicate selective loss of certain phases (e.g., feldspar, apatite) and over-representation of quartz and muscovite along cracks likely due to the effects of larger inclusion size and varying degrees of overpressure following zircon cooling and decompression. Inclusions not associated with cracks in magmatically zoned versus regions with disturbed zoning have similar phase proportions. This indicates only minor inclusion replacement away from cracks (i.e., the isolated assemblage is likely primary). This holds true also for inclusions within visually turbid versus clear volumes of zircon. Phase proportions within the inclusion assemblages differ with age indicating a

  16. Interrogating inclusive development in India's transition process.

    PubMed

    Chakrabarti, Anjan; Dhar, Anup

    2012-12-01

    This paper makes two related contributions. First, the dual economic structure underlying development is shown as producing a distinct conception of other comprising of a devalued third world which is foregrounded and world of the third which is excluded. This dyad of inclusion-exclusion of other is produced in relation to the centers of capitalism and modernism. The category of third world helps to displace the language-experience-logic-ethos of the other a la world of the third such that development works over and transforms world of the third, but via the trope of a devalued third world. We then use this framework to explore the relation of global capitalism with world of the third in the Indian context, a relation that is shown to be two fold. There is on one hand an attempt to dismantle world of the third as part of the development trope of overcoming the third world. On the other, through inclusive development, an attempt is made to directly intervene in the economy of world of the third so as to address the problems of income inequality and social exclusion, again under the trope of uplifting the devalued third world. PMID:23390797

  17. Measurement of inclusive (Ds+/-) photoproduction at HERA

    NASA Astrophysics Data System (ADS)

    Breitweg, J.; Chekanov, S.; Derrick, M.; Krakauer, D.; Magill, S.; Musgrave, B.; Pellegrino, A.; Repond, J.; Stanek, R.; Yoshida, R.; Mattingly, M. C. K.; Abbiendi, G.; Anselmo, F.; Antonioli, P.; Bari, G.; Basile, M.; Bellagamba, L.; Boscherini, D.; Bruni, A.; Bruni, G.; Cara Romeo, G.; Castellini, G.; Cifarelli, L.; Cindolo, F.; Contin, A.; Coppola, N.; Corradi, M.; De Pasquale, S.; Giusti, P.; Iacobucci, G.; Laurenti, G.; Levi, G.; Margotti, A.; Massam, T.; Nania, R.; Palmonari, F.; Pesci, A.; Polini, A.; Sartorelli, G.; Zamora Garcia, Y.; Zichichi, A.; Amelung, C.; Bornheim, A.; Brock, I.; Coböken, K.; Crittenden, J.; Deffner, R.; Hartmann, H.; Heinloth, K.; Hilger, E.; Irrgang, P.; Jakob, H.-P.; Kappes, A.; Katz, U. F.; Kerger, R.; Paul, E.; Schnurbusch, H.; Stifutkin, A.; Tandler, J.; Voss, K. C.; Weber, A.; Wieber, H.; Bailey, D. S.; Barret, O.; Brook, N. H.; Foster, B.; Heath, G. P.; Heath, H. F.; McFall, J. D.; Piccioni, D.; Rodrigues, E.; Scott, J.; Tapper, R. J.; Capua, M.; Mastroberardino, A.; Schioppa, M.; Susinno, G.; Jeoung, H. Y.; Kim, J. Y.; Lee, J. H.; Lim, I. T.; Ma, K. J.; Pac, M. Y.; Caldwell, A.; Liu, W.; Liu, X.; Mellado, B.; Paganis, S.; Sampson, S.; Schmidke, W. B.; Sciulli, F.; Chwastowski, J.; Eskreys, A.; Figiel, J.; Klimek, K.; Olkiewicz, K.; Piotrzkowski, K.; Przybycień, M. B.; Stopa, P.; Zawiejski, L.; Bednarek, B.; Jeleń, K.; Kisielewska, D.; Kowal, A. M.; Kowalski, T.; Przybycień, M.; Rulikowska-Zarȩbska, E.; Suszycki, L.; Szuba, D.; Kotański, A.; Bauerdick, L. A. T.; Behrens, U.; Bienlein, J. K.; Burgard, C.; Dannheim, D.; Desler, K.; Drews, G.; Fox-Murphy, A.; Fricke, U.; Goebel, F.; Göttlicher, P.; Graciani, R.; Haas, T.; Hain, W.; Hartner, G. F.; Hasell, D.; Hebbel, K.; Johnson, K. F.; Kasemann, M.; Koch, W.; Kötz, U.; Kowalski, H.; Lindemann, L.; Löhr, B.; Martínez, M.; Milite, M.; Monteiro, T.; Moritz, M.; Notz, D.; Pelucchi, F.; Petrucci, M. C.; Rohde, M.; Saull, P. R. B.; Savin, A. A.; Schneekloth, U.; Selonke, F.; Sievers, M.; Stonjek, S.; Tassi, E.; Wolf, G.; Wollmer, U.; Youngman, C.; Zeuner, W.; Coldewey, C.; Lopez-Duran Viani, A.; Meyer, A.; Schlenstedt, S.; Straub, P. B.; Barbagli, G.; Gallo, E.; Pelfer, P.; Maccarrone, G.; Votano, L.; Bamberger, A.; Benen, A.; Eisenhardt, S.; Markun, P.; Raach, H.; Wölfle, S.; Bussey, P. J.; Doyle, A. T.; Lee, S. W.; Macdonald, N.; McCance, G. J.; Saxon, D. H.; Sinclair, L. E.; Skillicorn, I. O.; Waugh, R.; Bohnet, I.; Gendner, N.; Holm, U.; Meyer-Larsen, A.; Salehi, H.; Wick, K.; Garfagnini, A.; Gialas, I.; Gladilin, L. K.; Kçira, D.; Klanner, R.; Lohrmann, E.; Poelz, G.; Zetsche, F.; Goncalo, R.; Long, K. R.; Miller, D. B.; Tapper, A. D.; Walker, R.; Mallik, U.; Cloth, P.; Filges, D.; Ishii, T.; Kuze, M.; Nagano, K.; Tokushuku, K.; Yamada, S.; Yamazaki, Y.; Ahn, S. H.; Lee, S. B.; Park, S. K.; Lim, H.; Park, I. H.; Son, D.; Barreiro, F.; García, G.; Glasman, C.; Gonzalez, O.; Labarga, L.; del Peso, J.; Redondo, I.; Terrón, J.; Barbi, M.; Corriveau, F.; Hanna, D. S.; Ochs, A.; Padhi, S.; Riveline, M.; Stairs, D. G.; Wing, M.; Tsurugai, T.; Bashkirov, V.; Dolgoshein, B. A.; Dementiev, R. K.; Ermolov, P. F.; Golubkov, Y. A.; Katkov, I. I.; Khein, L. A.; Korotkova, N. A.; Korzhavina, I. A.; Kuzmin, V. A.; Lukina, O. Y.; Proskuryakov, A. S.; Shcheglova, L. M.; Solomin, A. N.; Vlasov, N. N.; Zotkin, S. A.; Bokel, C.; Botje, M.; Brümmer, N.; Engelen, J.; Grijpink, S.; Koffeman, E.; Kooijman, P.; Schagen, S.; van Sighem, A.; Tiecke, H.; Tuning, N.; Velthuis, J. J.; Vossebeld, J.; Wiggers, L.; de Wolf, E.; Acosta, D.; Bylsma, B.; Durkin, L. S.; Gilmore, J.; Ginsburg, C. M.; Kim, C. L.; Ling, T. Y.; Boogert, S.; Cooper-Sarkar, A. M.; Devenish, R. C. E.; Große-Knetter, J.; Matsushita, T.; Ruske, O.; Sutton, M. R.; Walczak, R.; Bertolin, A.; Brugnera, R.; Carlin, R.; Dal Corso, F.; Dosselli, U.; Dusini, S.; Limentani, S.; Morandin, M.; Posocco, M.; Stanco, L.; Stroili, R.; Voci, C.; Adamczyk, L.; Iannotti, L.; Oh, B. Y.; Okrasiński, J. R.; Toothacker, W. S.; Whitmore, J. J.; Iga, Y.; D'Agostini, G.; Marini, G.; Nigro, A.; Cormack, C.; Hart, J. C.; McCubbin, N. A.; Shah, T. P.; Epperson, D.; Heusch, C.; Sadrozinski, H. F.-W.; Seiden, A.; Wichmann, R.; Williams, D. C.; Pavel, N.; Abramowicz, H.; Dagan, S.; Kananov, S.; Kreisel, A.; Levy, A.; Abe, T.; Fusayasu, T.; Umemori, K.; Yamashita, T.; Hamatsu, R.; Hirose, T.; Inuzuka, M.; Kitamura, S.; Nishimura, T.; Arneodo, M.; Cartiglia, N.; Cirio, R.; Costa, M.; Ferrero, M. I.; Maselli, S.; Monaco, V.; Peroni, C.; Ruspa, M.; Sacchi, R.; Solano, A.; Staiano, A.; Dardo, M.; Bailey, D. C.; Fagerstroem, C.-P.; Galea, R.; Koop, T.; Levman, G. M.; Martin, J. F.; Orr, R. S.; Polenz, S.; Sabetfakhri, A.; Simmons, D.; Butterworth, J. M.; Catterall, C. D.; Hayes, M. E.; Heaphy, E. A.; Jones, T. W.; Lane, J. B.; West, B. J.; Ciborowski, J.; Ciesielski, R.; Grzelak, G.; Nowak, R. J.; Pawlak, J. M.; Pawlak, R.; Smalska, B.; Tymieniecka, T.; Wróblewski, A. K.; Zakrzewski, J. A.; Z˙arnecki, A. F.; Adamus, M.; Gadaj, T.; Deppe, O.; Eisenberg, Y.; Hochman, D.; Karshon, U.; Badgett, W. F.; Chapin, D.; Cross, R.; Foudas, C.; Mattingly, S.; Reeder, D. D.; Smith, W. H.; Vaiciulis, A.; Wildschek, T.; Wodarczyk, M.; Deshpande, A.; Dhawan, S.; Hughes, V. W.; Bhadra, S.; Catterall, C.; Cole, J. E.; Frisken, W. R.; Hall-Wilton, R.; Khakzad, M.; Menary, S.

    2000-05-01

    The first measurement of inclusive Ds+/- photoproduction at HERA has been performed with the ZEUS detector for photon-proton centre-of-mass energies 130DsX=3.79+/- 0.59(stat.)+0.26-0.46(syst.)+/-0.94(br.)nb, where the last error arises from the uncertainty in the Ds+/- decay branching ratio. The measurements are compared with inclusive D*+/- photoproduction cross sections in the same kinematic region and with QCD calculations. The Ds+/- cross sections lie above a fixed-order next-to-leading order calculation and agree better with a tree-level O(ααs3) calculation that was tuned to describe the ZEUS D*+/- cross sections. The ratio of Ds+/- to D*+/- cross sections is 0.41+/-0.07(stat.)+0.03-0.05(syst.)+/-0.10(br.). From this ratio, the strangeness-suppression factor in charm photoproduction, within the LUND string fragmentation model, has been calculated to be γs=0.27+/-0.05+/-0.07(br.). The cross-section ratio and γs are in good agreement with those obtained in charm production in e+e- annihilation.

  18. Cytomegalic inclusion disease in the adult

    PubMed Central

    Evans, D. J.; Williams, E. D.

    1968-01-01

    The distribution of infected cells in 13 necropsies on adults with cytomegalovirus disease is reported and discussed in relation to the local damage caused by the infection and predisposing factors. The distribution, with lung as the most common site, but other organs such as thyroid, liver, and colon not infrequently involved, agrees fairly well with other series. No heavy infection confined to one organ was found, and it is concluded that a truly localized infection in the adult probably does not occur. Evidence of destructive inflammatory changes attributable to the virus was scanty; a lymphocyte and plasma cell infiltrate was sometimes found, and microglial nodules were found in a case with inclusions in the brain. In one case heavy cytomegalovirus infection in the colon was associated with, and probably caused, marked colonic ulceration which led to the death of the patient. The major predisposing factor to infection in this series was corticosteroid therapy: eight of the 13 patients had been treated with steroids and one had Cushing's syndrome associated with a bronchial carcinoma. Three of the other four patients had a very few inclusions only. Adrenal involvement was not found in any of the steroid-treated patients but was present in two of the four patients not treated with steroids where adrenal sections were available. It is concluded that most adult patients with cytomegalovirus infection have impaired immune mechanisms, and that heavy infection may rarely lead to a clinically serious disease. Images PMID:4301686

  19. Valuing Student Teachers' Perspectives: Researching Inclusively in Inclusive Education?

    ERIC Educational Resources Information Center

    Black-Hawkins, Kristine; Amrhein, Bettina

    2014-01-01

    This paper considers how engaging with the principles of inclusive research can enhance research studies that set out to understand the experiences of student teachers on initial teacher education programmes. It does so by describing the methodological development of an on-going study of student teachers' perspectives on working with diverse…

  20. Inclusive/Exclusive? Contradictory Perspectives on Autism and Inclusion: The Case for an Integrative Position

    ERIC Educational Resources Information Center

    Ravet, Jackie

    2011-01-01

    This paper explores some of the tensions that frequently arise in debates about inclusion and the education of children and young people on the autism spectrum. This debate is often characterised by bipolar thinking and moral posturing, and is obscured by misunderstandings and omissions. This can create confusion for practitioners trying their…

  1. Preparing Teachers for Inclusive Education: Using Inclusive Pedagogy to Enhance Teaching and Learning for All

    ERIC Educational Resources Information Center

    Florian, Lani; Linklater, Holly

    2010-01-01

    As the concept of "inclusive education" has gained currency, students who would previously have been referred to specialist forms of provision, having been judged "less able", are now believed to belong in mainstream classrooms. However, it is often argued that teachers lack the necessary knowledge and skills to work with such students in…

  2. Marking Time: Using Music to Create Inclusive Religious Education and Inclusive Schools

    ERIC Educational Resources Information Center

    Stern, Julian

    2004-01-01

    Religious education (RE) is a vital subject in the inclusion of pupils and staff alike, as it brings together ways of life and communities, the personal and the social. Based on the philosophy of community of John Macmurray, and the philosophy of dialogue of Martin Buber, Julian Stern investigates ways of marking time, understanding and…

  3. Behavioral and Academic Differences between an Inclusive and Non-Inclusive Classroom

    ERIC Educational Resources Information Center

    Hatch, Sherry Lynn

    2013-01-01

    Although educators continue to provide all students access to their grade-level curriculum, students with disabilities are not performing academically in accordance with state standards. The purpose of this sequential transformative mixed methods study was to investigate academic and/or behavioral differences between an inclusion classroom and a…

  4. Preventing Inclusion? Inclusive Early Childhood Education and the Option to Exclude

    ERIC Educational Resources Information Center

    Cologon, Kathy

    2014-01-01

    While there is increasing international commitment to inclusive education, as outlined in the United Nations Convention on the Rights of Persons with Disabilities (CRPD), many children remain excluded at school. One marginalised and frequently excluded group of people are people who experience disability. In the recently released first report on…

  5. Promoting Inclusion? "Inclusive" and Effective Head Teachers' Descriptions of Their Work

    ERIC Educational Resources Information Center

    Lindqvist, Gunilla; Nilholm, Claes

    2014-01-01

    The purpose of the reported interview study from Sweden is to contribute to our understanding of how head teachers can promote inclusive practices. Five head teachers were selected from a larger sample of head teachers working in compulsory schools (6-16) according to specific criteria in order to obtain head teachers who work effectively and…

  6. Moving toward Inclusion: Inclusion Coaches' Reflections and Discussions in Supporting Educators in Practice

    ERIC Educational Resources Information Center

    Wlodarczyk, Kathy Ann; Somma, Monique; Bennett, Sheila; Gallagher, Tiffany L.

    2015-01-01

    When school systems and administrations provide educators with opportunities to engage in transformative learning through reflective practice and provide opportunities to challenge their beliefs, educator pedagogy for inclusive education can be enhanced (Evans, 1997; Pyha¨lto¨ et al., 2012; Richardson, 1998). Our research examined the experiences…

  7. Leadership to Promote Inclusion: Perceptions of Elementary Principals on Inclusion, Co-Teaching, and Differentiated Instruction

    ERIC Educational Resources Information Center

    Murray, Michelle L.

    2012-01-01

    The Individuals with Disabilities Act mandates that all students with or without disabilities should be included in the regular education classroom to the greatest extent appropriate. Research shows the importance of the principal's ability to shape programs, policies and school cultures that are supportive of inclusion. Deploying a modified…

  8. Thinking Change Inclusively: Views of Educational Administrators on Inclusive Education as a Reform Initiative

    ERIC Educational Resources Information Center

    Sakiz, Halis

    2016-01-01

    This paper is an attempt to delve into the debate about educational change and evaluate this concept around the paradigms introduced by inclusive education. The paper embarks on views of 27 educational administrators working in different educational institutions in Turkey. Participants are asked to provide their views on educational change and the…

  9. Psychology's Role in Inclusive Education: Observations from New Brunswicks's Recent Review of Inclusion

    ERIC Educational Resources Information Center

    Williams, Robert B.; French, Laurence A.

    2007-01-01

    Psychologists are amongst the professionals who assess children to identify and prescribe for those with learning differences. They currently carry out these assessments in the context of the practice of inclusive education that involves providing for all children's educational needs in regular classroom settings. Recently, some psychologists have…

  10. Signs of an Inclusive School: A Parent's Perspective on the Meaning and Value of Authentic Inclusion

    ERIC Educational Resources Information Center

    Swedeen, Beth L.

    2009-01-01

    Although increasing numbers of schools say they are adopting inclusive models of service delivery, many students with significant disabilities continue to experience segregation and isolation in school settings. This article, written from a parent's perspective, highlights a series of questions that school leadership, educators, and families can…

  11. Inclusion as an Instructional Approach: Fostering Inclusive Writing Communities in Preschool Classrooms

    ERIC Educational Resources Information Center

    McCloskey, Erin

    2012-01-01

    Preschool students with disabilities engage in social interaction with peers less often than children developing typically in inclusive classrooms. This research explores how divergent theories of literacy learning, those inherent in the structure of special education and those promoted by scholars interested in emergent literacy learning, impact…

  12. Taking Action toward Inclusion: Organizational Change and the Inclusion of People with Disabilities in Museum Learning

    ERIC Educational Resources Information Center

    Reich, Christine A.

    2014-01-01

    This study examined organizational change in science museums toward practices that are inclusive of people with disabilities. Guided by two overarching frameworks, organizational learning and the social model of disability, this study sought to answer the following: What are the contexts and processes that facilitate, sustain, or impede a science…

  13. Selection, Inclusion, Evaluation and Defense of Transgender-Inclusive Fiction for Young Adults: A Resource Guide

    ERIC Educational Resources Information Center

    Rockefeller, Elsworth I.

    2009-01-01

    An increasingly visible youth transgender population is emerging and the number of transgender-inclusive fiction texts for young adults is growing. Adults serving teens in schools, libraries, and community agencies must begin actively pursuing, utilizing, and incorporating these texts into resource collections. This article provides an overview of…

  14. Where Do Mexico and Chile Stand on Inclusive Education? Short Title: Inclusion in Mexico and Chile

    ERIC Educational Resources Information Center

    García-Cedillo, Ismael; Romero-Contreras, Silvia; Ramos-Abadie, Liliana

    2015-01-01

    This paper discusses the background, current situation and challenges of educational integration and inclusive education in Mexico and Chile. These countries obtained similar low results on the academic achievement of their students (Mexico last and Chile second last) among OECD countries; and above average scores, among Latin-American countries.…

  15. Diffusive over-hydration of olivine-hosted melt inclusions

    NASA Astrophysics Data System (ADS)

    Hartley, Margaret E.; Neave, David A.; Maclennan, John; Edmonds, Marie; Thordarson, Thor

    2015-09-01

    The pre-eruptive water content of magma is often estimated using crystal-hosted melt inclusions. However, olivine-hosted melt inclusions are prone to post-entrapment modification by H+ diffusion as they re-equilibrate with their external environment. This effect is well established for the case of H+ loss from olivine-hosted inclusions that have cooled slowly in degassed magma. Here we present evidence for the opposite effect: the addition of H+ into inclusions that are held in melts that are enriched in H2O with respect to the trapped melts. The compositional variability in a suite of 211 olivine-hosted inclusions from the Laki and Skuggafjöll eruptions in Iceland's Eastern Volcanic Zone indicates that diffusive H+ gain governs the H2O content of incompatible trace element depleted inclusions. Individual eruptive units contain olivine-hosted inclusions with widely varying incompatible element concentrations but near-constant H2O. Furthermore, over 40% of the inclusions have H2 O /Ce > 380, significantly higher than the H2O/Ce expected in primary Icelandic melts or mid-ocean ridge basalts (150-280). The fact that the highest H2O/Ce ratios are found in the most incompatible element depleted inclusions indicates that hydration is a consequence of the concurrent mixing and crystallisation of compositionally diverse primary melts. Hydration occurs when olivines containing depleted inclusions with low H2O contents are juxtaposed against more hydrous melts during mixing. Melt inclusions from a single eruption may preserve evidence of both diffusive H+ loss and H+ gain. Trace element data are therefore vital for determining H2O contents of melt inclusions at the time of inclusion trapping and, ultimately, the H2O content of the mantle source regions.

  16. Monotone viable trajectories for functional differential inclusions

    NASA Astrophysics Data System (ADS)

    Haddad, Georges

    This paper is a study on functional differential inclusions with memory which represent the multivalued version of retarded functional differential equations. The main result gives a necessary and sufficient equations. The main result gives a necessary and sufficient condition ensuring the existence of viable trajectories; that means trajectories remaining in a given nonempty closed convex set defined by given constraints the system must satisfy to be viable. Some motivations for this paper can be found in control theory where F( t, φ) = { f( t, φ, u)} uɛU is the set of possible velocities of the system at time t, depending on the past history represented by the function φ and on a control u ranging over a set U of controls. Other motivations can be found in planning procedures in microeconomics and in biological evolutions where problems with memory do effectively appear in a multivalued version. All these models require viability constraints represented by a closed convex set.

  17. Ancient asteroids enriched in refractory inclusions.

    PubMed

    Sunshine, J M; Connolly, H C; McCoy, T J; Bus, S J; La Croix, L M

    2008-04-25

    Calcium- and aluminum-rich inclusions (CAIs) occur in all classes of chondritic meteorites and contain refractory minerals predicted to be the first condensates from the solar nebula. Near-infrared spectra of CAIs have strong 2-micrometer absorptions, attributed to iron oxide-bearing aluminous spinel. Similar absorptions are present in the telescopic spectra of several asteroids; modeling indicates that these contain approximately 30 +/- 10% CAIs (two to three times that of any meteorite). Survival of these undifferentiated, large (50- to 100-kilometer diameter) CAI-rich bodies suggests that they may have formed before the injection of radiogenic 26Al into the solar system. They have also experienced only modest post-accretionary alteration. Thus, these asteroids have higher concentrations of CAI material, appear less altered, and are more ancient than any known sample in our meteorite collection, making them prime candidates for sample return. PMID:18356491

  18. Inclusive Inelastic Electron Scattering from Nuclei

    SciTech Connect

    Fomin, Nadia

    2007-10-26

    Inclusive electron scattering from nuclei at large x and Q{sup 2} is the result of a reaction mechanism that includes both quasi-elastic scattering from nucleons and deep inelastic scattering from the quark consitituents of the nucleons. Data in this regime can be used to study a wide variety of topics, including the extraction of nuclear momentum distributions, the infiuence of final state interactions and the approach to y-scaling, the strength of nucleon-nucleon correlations, and the approach to x-scaling, to name a few. Selected results from the recent experiment E02-019 at the Thomas Jefferson National Accelerator Facility will be shown and their relevance discussed.

  19. Proposed Inclusive Dark Photon Search at LHCb

    NASA Astrophysics Data System (ADS)

    Ilten, Philip; Soreq, Yotam; Thaler, Jesse; Williams, Mike; Xue, Wei

    2016-06-01

    We propose an inclusive search for dark photons A' at the LHCb experiment based on both prompt and displaced dimuon resonances. Because the couplings of the dark photon are inherited from the photon via kinetic mixing, the dark photon A'→μ+μ- rate can be directly inferred from the off-shell photon γ*→μ+μ- rate, making this a fully data-driven search. For run 3 of the LHC, we estimate that LHCb will have sensitivity to large regions of the unexplored dark-photon parameter space, especially in the 210-520 MeV and 10-40 GeV mass ranges. This search leverages the excellent invariant-mass and vertex resolution of LHCb, along with its unique particle-identification and real-time data-analysis capabilities.

  20. Inclusive Educative Technologies, for people with disabilities

    NASA Astrophysics Data System (ADS)

    Echenique, AM; Graffigna, JP; Pérez, E.; López, N.; Piccinini, D.; Fernández, H.; Garcés, A.

    2016-04-01

    The conventional educational environment imposes barriers to education for people with disabilities, limiting their rights, which is a non-discriminative education. In turn, hampers their access to other rights and creates huge obstacles to realize their potential and participate effectively in their communities. In this sense Assistive Technology provides alternative solutions, in order to compensate for a lost or diminished ability. Thus the necessary assistance is provided to perform tasks, including those related to education, improving the inclusion. In this paper some researches had been made in the Gabinete de TecnologiaMedica, in the Facultad de Ingenieria of the Universidad Nacional de San Juan in order to solve this problem. The researchers are classified by type of disability; sensory (visual and auditory) or motor. They have been designed, developed and experienced through various prototypes that have given satisfactory results. It had been published in national and international congresses of high relevance.

  1. Counit Inclusion in Hydrogenated Polynorbornene Copolymer Crystals

    NASA Astrophysics Data System (ADS)

    Burns, Adam; Showak, Michael; Stella, Andrew; Register, Richard

    2014-03-01

    Crystallization in poly(A-co-B) random copolymers, where homopolymer A is crystalline but B is not, is dictated by the degree to which crystals of A can include B units. Typically, B units are strongly excluded from the A crystals, drastically reducing the degree of crystallinity wc and crystal thickness tc even at modest comonomer contents. However, in some cases, B units can be incorporated into the crystals as defects, significantly diminishing the counits' impact on wc and tc. The extent and consequences of counit inclusion have been investigated in hydrogenated polynorbornene (hPN) with alkylnorbornene counits, synthesized by living ring-opening metathesis polymerization followed by hydrogenation. In the case of 5-hexylnorbornene (HxN) counits, a steep decline in wc and tc with counit content is found, indicative of strong exclusion. In contrast, when the counits are 5-methylnorbornene (MeN), extensive inclusion of MeN units into the crystals is observed. hP(N-co-MeN) copolymers maintain appreciable crystallinity above 30 mol% MeN, and the dependence of the melting point Tm on tc tracks that of the hPN homopolymer. Four times as much MeN as HxN (molar basis) is required to produce a comparable drop in wc. Therefore, copolymerization with MeN can be used to tune Tm without drastically reducing wc. Additionally, hPN exhibits a polymorphic transition to a rotationally disordered (RD) crystal at temperature Tcc

  2. Enhanced Inclusion Removal from Steel in the Tundish

    SciTech Connect

    R. C. Bradt; M.A.R. Sharif

    2009-09-25

    The objective of this project was to develop an effective chemical filtering system for significantly reducing the content of inclusion particles in the steel melts exiting the tundish for continuous casting. This project combined a multi-process approach that aimed to make significant progress towards an "inclusion free" steel by incorporating several interdependent concepts to reduce the content of inclusions in the molten steel exiting the tundish for the caster. The goal is to produce "cleaner" steel.

  3. Petrographic studies of refractory inclusions from the Murchison meteorite

    NASA Astrophysics Data System (ADS)

    MacPherson, G. J.; Grossman, L.; Hashimoto, A.; Bar-Matthews, M.; Tanaka, T.

    1984-11-01

    Textural and mineral-chemical data on freeze-thaw disaggregated refractory inclusions from the Murchison meteorite are reported. The data were obtained with neutron activation analysis, SEM, and spectroscopy, the study revealed corundum-bearing inclusions, spinel-hibonite aggregates and spherules, and spinel-pyroxene and elivine-pyroxene inclusions. One of the three spinel-, pyroxene-, forsterite-rich inclusions had an amoeba-shaped spinel-pyroxene core, implying vapor-to-solid condensation and therefore crystallization from a melt. It is concluded that the meteorite formation encompassed diverse nebular materials, and that further studies of the meteorite will enhance the data base on the planetary nebular processes.

  4. Petrographic studies of refractory inclusions from the Murchison meteorite

    SciTech Connect

    Macpherson, G.J.; Grossman, L.; Hashimoto, A.; Bar-Matthews, M.

    1984-11-15

    Textural and mineral-chemical data on freeze-thaw disaggregated refractory inclusions from the Murchison meteorite are reported. The data were obtained with neutron activation analysis, SEM, and spectroscopy, the study revealed corundum-bearing inclusions, spinel-hibonite aggregates and spherules, and spinel-pyroxene and elivine-pyroxene inclusions. One of the three spinel-, pyroxene-, forsterite-rich inclusions had an amoeba-shaped spinel-pyroxene core, implying vapor-to-solid condensation and therefore crystallization from a melt. It is concluded that the meteorite formation encompassed diverse nebular materials, and that further studies of the meteorite will enhance the data base on the planetary nebular processes.

  5. Petrographic studies of refractory inclusions from the Murchison meteorite

    NASA Technical Reports Server (NTRS)

    Macpherson, G. J.; Grossman, L.; Hashimoto, A.; Bar-Matthews, M.; Tanaka, T.

    1984-01-01

    Textural and mineral-chemical data on freeze-thaw disaggregated refractory inclusions from the Murchison meteorite are reported. The data were obtained with neutron activation analysis, SEM, and spectroscopy, the study revealed corundum-bearing inclusions, spinel-hibonite aggregates and spherules, and spinel-pyroxene and elivine-pyroxene inclusions. One of the three spinel-, pyroxene-, forsterite-rich inclusions had an amoeba-shaped spinel-pyroxene core, implying vapor-to-solid condensation and therefore crystallization from a melt. It is concluded that the meteorite formation encompassed diverse nebular materials, and that further studies of the meteorite will enhance the data base on the planetary nebular processes.

  6. Refractory inclusions in the Ornans C30 chondrite

    NASA Technical Reports Server (NTRS)

    Davis, A. M.

    1985-01-01

    Several types of metedorites contain unusual objects 10 micrometers to 2 centimeters across that are enriched in refractory elements such as calcium, aluminum and titanium. These objects, commonly known as refractory inclusions, are most abundant in the meteorites known as carbonaceous chondrites. The refractory inclusions that have been found in the Ornans metedorite, a member of a little-studied group of carbonaceous chondrites are described. Some refractory inclusions in Ornans resemble those found in other meteorites, while others are unlike any seen before. The unusual inclusions in Ornans contain minerals with extraordinary enrichments in highly refractory elements.

  7. Melt inclusions in veins: linking magmas and porphyry Cu deposits.

    PubMed

    Harris, Anthony C; Kamenetsky, Vadim S; White, Noel C; van Achterbergh, Esmé; Ryan, Chris G

    2003-12-19

    At a porphyry copper-gold deposit in Bajo de la Alumbrera, Argentina, silicate-melt inclusions coexist with hypersaline liquid- and vapor-rich inclusions in the earliest magmatic-hydrothermal quartz veins. Copper concentrations of the hypersaline liquid and vapor inclusions reached maxima of 10.0 weight % (wt %) and 4.5 wt %, respectively. These unusually copper-rich inclusions are considered to be the most primitive ore fluid found thus far. Their preservation with coexisting melt allows for the direct quantification of important oreforming processes, including determination of bulk partition coefficients of metals from magma into ore-forming magmatic volatile phases. PMID:14684818

  8. Process Dependence and the Sivers Effect in Inclusive and Semi-Inclusive Reactions

    SciTech Connect

    Gamberg, Leonard P.; Kang, Zhong-Bo; Prokudin, Alexei

    2014-01-01

    We perform an analysis of the the spin asymmetry for single inclusive jet production in proton-proton collisions collected by AnDY experiment and the Sivers asymmetry data from semi-inclusive deep inelastic scattering experiments. In particular, we consider the role color gauge invariance plays in determining the process-dependence of the Sivers effect. We find that after carefully taking into account the initial-state and final-state interactions between the active parton and the remnant of the polarized hadron, the calculated jet spin asymmetry based on the Sivers functions extracted from HERMES and COMPASS experiments is consistent with the AnDY experimental data. This provides a first indication for the process-dependence of the Sivers effect in different processes. We also make predictions for both direct photon and Drell-Yan spin asymmetry, to further test the process-dependence of the Sivers effect in future experiments.

  9. Role for Chlamydial Inclusion Membrane Proteins in Inclusion Membrane Structure and Biogenesis

    PubMed Central

    Mital, Jeffrey; Miller, Natalie J.; Dorward, David W.; Dooley, Cheryl A.; Hackstadt, Ted

    2013-01-01

    The chlamydial inclusion membrane is extensively modified by the insertion of type III secreted effector proteins. These inclusion membrane proteins (Incs) are exposed to the cytosol and share a common structural feature of a long, bi-lobed hydrophobic domain but little or no primary amino acid sequence similarity. Based upon secondary structural predictions, over 50 putative inclusion membrane proteins have been identified in Chlamydia trachomatis. Only a limited number of biological functions have been defined and these are not shared between chlamydial species. Here we have ectopically expressed several C. trachomatis Incs in HeLa cells and find that they induce the formation of morphologically distinct membranous vesicular compartments. Formation of these vesicles requires the bi-lobed hydrophobic domain as a minimum. No markers for various cellular organelles were observed in association with these vesicles. Lipid probes were incorporated by the Inc-induced vesicles although the lipids incorporated were dependent upon the specific Inc expressed. Co-expression of Inc pairs indicated that some colocalized in the same vesicle, others partially overlapped, and others did not associate at all. Overall, it appears that Incs may have an intrinsic ability to induce membrane formation and that individual Incs can induce membranous structures with unique properties. PMID:23696825

  10. Fluid inclusion analyses of detrital quartz grains - new Provenance Tool

    SciTech Connect

    Bloch, J.D.

    1985-02-01

    Preliminary analyses by microthermometry of fluid inclusions in detrital quartz of the Upper Cambrian Lamotte Sandstone revealed the occurrence of 2 distinct groups of aqueous fluid inclusions. Specific salinity signatures and homogenization temperatures may be used to distinguish specific granite types of the source rock terrain. The inclusions chosen for analysis occur in isolated clusters or are randomly distributed within a grain, commonly in association with mineral inclusions of zircon, sphene, rutile, and/or tourmaline. Secondary inclusions are present in the Lamotte but are not included in this study. The first group of inclusions is characterized by low salinities (< 1.0-8.0 wt.% eq. NaCl), the second by high salinities (12.1-29.6 wt. % eq. NaCl). Final melting temperatures as low as -30.6/sup 0/C indicate the presence of divalent ions in these inclusions. Both groups yield homogenization temperatures of between 150/sup 0/C and 220/sup 0/C. The low-salinity inclusions occur predominantly in subrounded to well-rounded sand less than 1.0 mm in size that is derived from a distal source. The brine inclusions occur exclusively in subangular to angular gravel 2.0-3.0 mm in size, implying a more proximal source area. A comparison of these inclusions with inclusions found in the granites of the apparent source terrain indicates that a medium-silica amphiboleorthoclase granite (Slabtown type) or a low-silica amphibole-plagioclase granite (Sivermines type) or both are the primary source rocks for this quartz. These granite types have limited areal distribution in the present day St. Francois mountains and the identification of these granite types as the source rock for the locally derived quartz has broad implications for reconstructing Cambrian depositional environments and paleostructure of the ancient St. Francois mountains.

  11. Fluid Inclusions in Extraterrestrial Samples Fact or Fiction?

    NASA Technical Reports Server (NTRS)

    Bodnar, R. J.; Zolensky, M. E.; Gibson, E. K.

    2000-01-01

    Over the years there have been numerous reports of liquid inclusions in meteorites. Roedder reviews the reported occurrences of liquid inclusions in meteorites and states that "silicate-melt inclusions are expectable and apparently ubiquitous, but the presence of actual liquid inclusions (i.e., with moving bubbles at room temperature) would seem almost impossible." The reason for this conclusion is that meteorites (presumably) form in space at high temperatures and very low pressures where liquid water (or carbon dioxide) is not stable. Perhaps the most infamous report of fluid inclusions in meteorites was that of Warner et al. In that study, the authors reported the presence of two-phase, liquid-vapor inclusions in a diogenite from Antarctica. This report of fluid inclusions generated considerable interest in the meteorite community, and caused many to question existing models for the origin of the diogenites. This interest was short-lived however, as later investigations of the same samples showed that the inclusions were most likely artifacts. Rudnick et al. showed that many of the inclusions in meteorites prepared at the Johnson Space Center contained a fluid that fluoresced strongly under the laser beam on the Raman microprobe. They interpreted this to indicate that the inclusions contained Almag oil used in the preparation of thin sections. Presumably, the Almag oil entered empty vesicles along fractures that were opened intermittently during cutting. Here, the occurrence of unambiguous fluid inclusions that could not have been introduced during sample preparation are described in samples from two different extraterrestrial environments. One environment is represented by the SNC (martian) meteorites ALH 84001 and Nakhla. The second environment is represented by the Monahans 1998 meteorite that fell recently in the USA.

  12. Ceramic Inclusions In Powder Metallurgy Disk Alloys: Characterization and Modeling

    NASA Technical Reports Server (NTRS)

    Bonacuse, Pete; Kantzos, Pete; Telesman, Jack

    2002-01-01

    Powder metallurgy alloys are increasingly used in gas turbine engines, especially as the material chosen for turbine disks. Although powder metallurgy materials have many advantages over conventionally cast and wrought alloys (higher strength, higher temperature capability, etc.), they suffer from the rare occurrence of ceramic defects (inclusions) that arise from the powder atomization process. These inclusions can have potentially large detrimental effect on the durability of individual components. An inclusion in a high stress location can act as a site for premature crack initiation and thereby considerably reduce the fatigue life. Because these inclusions are exceedingly rare, they usually don't reveal themselves in the process of characterizing the material for a particular application (the cumulative volume of the test bars in a fatigue life characterization is typically on the order of a single actual component). Ceramic inclusions have, however, been found to be the root cause of a number of catastrophic engine failures. To investigate the effect of these inclusions in detail, we have undertaken a study where a known population of ceramic particles, whose composition and morphology are designed to mimic the 'natural' inclusions, are added to the precursor powder. Surface connected inclusions have been found to have a particularly large detrimental effect on fatigue life, therefore the volume of ceramic 'seeds' added is calculated to ensure that a minimum number will occur on the surface of the fatigue test bars. Because the ceramic inclusions are irregularly shaped and have a tendency to break up in the process of extrusion and forging, a method of calculating the probability of occurrence and expected intercepted surface and embedded cross-sectional areas were needed. We have developed a Monte Carlo simulation to determine the distributions of these parameters and have verified the simulated results with observations of ceramic inclusions found in macro

  13. Inclusion of Scatter in HADES: Final Report

    SciTech Connect

    Aufderheide, M B

    2010-12-20

    Covert nuclear attack is one of the foremost threats facing the United States and is a primary focus of the War on Terror. The Domestic Nuclear Detection Office (DNDO), within the Department of Homeland Security (DHS), is chartered to develop, and improve domestic systems to detect and interdict smuggling for the illicit use of a nuclear explosive device, fissile material or radiologica1 material. The CAARS (Cargo Advanced Automated Radiography System) program is a major part of the DHS effort to enhance US security by harnessing cutting-edge technologies to detect radiological and nuclear threats at points of entry to the United States. DNDO has selected vendors to develop complete radiographic systems. It is crucial that the initial design and testing concepts for the systems be validated and compared prior to the substantial efforts to build and deploy prototypes and subsequent large-scale production. An important aspect of these systems is the scatter which interferes with imaging. Monte Carlo codes, such as MCNP (X-5 Monte Carlo Team, 2005 Revision) allow scatter to be calculatied, but these calculations are very time consuming. It would be useful to have a fast scatter estimation algorithm in a fast ray tracing code. We have been extending the HADES ray-tracing radiographic simulation code to model vendor systems in a flexible and quick fashion and to use this tool to study a variety of questions involving system performance and the comparative value of surrogates. To enable this work, HADES has been linked to the BRL-CAD library (BRL-CAD Open Source Project, 2010), in order to enable the inclusion of complex CAD geometries in simulations, scanner geometries have been implemented in HADES, and the novel detector responses have been included in HADES. A major extension of HADES which has been required by this effort is the inclusion of scatter in these radiographic simulations. Ray tracing codes generally do not easily allow the inclusion of scatter, because

  14. Sources of carbon in inclusion bearing diamonds

    NASA Astrophysics Data System (ADS)

    Stachel, Thomas; Harris, Jeff W.; Muehlenbachs, Karlis

    2009-11-01

    The carbon isotopic composition ( δ13C) of diamonds containing peridotitic, eclogitic, websteritic and ultra-deep inclusions is re-evaluated on a detailed level. Applying a binning interval of 0.25‰, the previously recognized mode of peridotitic and eclogitic diamonds at about - 5‰ is shown to reflect at least two subpopulations with abundance peaks at ˜ - 5.75 to - 4.75‰ and ˜ - 4.50 to - 3.50‰. Within the peridotitic suite, diamonds with lherzolitic inclusions overall show higher δ13C values. Evolution away from a δ13C value of ˜ - 5‰, towards both 13C depleted and enriched compositions, is accompanied by decreasing maximum nitrogen contents of peridotitic diamonds. In combination with data on diamonds synthesized under reducing (metal melts) and more oxidizing conditions (carbonate-silicate interactions), this is taken to indicate that nitrogen is a compatible element in diamond that becomes depleted in the growth medium during progressive diamond precipitation. The observed co-variations of nitrogen content and δ13C around - 5‰ can then be modelled as reflecting closed system Rayleigh fractionation during crystallization of diamond from fluids/melts that are both reducing (i.e. methane bearing; evolution from ˜ - 5 to - 10‰) and oxidizing (i.e. CO 32- bearing; evolution from starting points varying between ˜ - 9 to - 5‰ and extending to about 0‰). Lherzolitic diamonds are believed to be mainly derived from diamond forming events subsequent to precipitation of predominantly Mesoarchean harzburgitic diamonds. The shift of lherzolitic diamonds towards higher δ13C values thus may relate to a temporal evolution, with carbonate bearing fluids with an initial isotopic composition ranging between about - 5.5 and - 1.5‰, derived from subducting oceanic crust, becoming increasingly important subsequent to the Mesoarchean. Devolatilization of marine carbonates ( δ13C ˜ 0‰) drives their isotopic composition towards mantle like values and

  15. Inclusive Discourse in Greece: Strong Voices, Weak Policies

    ERIC Educational Resources Information Center

    Zoniou-Sideri, Athina; Deropoulou-Derou, Eudoxia; Karagianni, Panagiota; Spandagou, Ilektra

    2006-01-01

    This paper explores the inclusive discourse in Greece at a period characterized by change in policy and practice. The aim is to discuss critically the distance between the strong voices and weak practices that characterizes the Greek inclusive discourse. The first part focuses on disability and presents the ways that a "common sense" understanding…

  16. 24 CFR 3286.813 - Inclusion in state plan.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false Inclusion in state plan. 3286.813 Section 3286.813 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT MANUFACTURED HOME INSTALLATION PROGRAM State Programs § 3286.813 Inclusion in...

  17. 46 CFR 201.117 - Inclusion in record.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Inclusion in record. 201.117 Section 201.117 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION POLICY, PRACTICE AND PROCEDURE RULES OF PRACTICE AND PROCEDURE Discovery and Depositions (Rule 11) § 201.117 Inclusion in record. No deposition or part...

  18. 45 CFR 302.17 - Inclusion of State statutes.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false Inclusion of State statutes. 302.17 Section 302.17 Public Welfare Regulations Relating to Public Welfare OFFICE OF CHILD SUPPORT ENFORCEMENT (CHILD SUPPORT... PLAN REQUIREMENTS § 302.17 Inclusion of State statutes. The State plan shall provide a copy of...

  19. Inclusive Education: An Examination of School Relationships and Student Interactions

    ERIC Educational Resources Information Center

    Sanchez-Marti, Angelina; Ramirez-Iniguez, Alma A.

    2012-01-01

    The aim of this paper is to examine inclusive education in multicultural contexts from an interaction networks perspective. The paper is based on the idea that inclusive education can be better understood by studying how native and non-native students interact, and what kinds of networks they establish in school. To do so, we assume two premises:…

  20. 34 CFR 603.22 - Inclusion on list.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false Inclusion on list. 603.22 Section 603.22 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION... § 603.22 Inclusion on list. Any State agency which desires to be listed by the Secretary as meeting...