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Sample records for acoustic cavitation bubbles

  1. Enhancing acoustic cavitation using artificial crevice bubbles.

    PubMed

    Zijlstra, Aaldert; Fernandez Rivas, David; Gardeniers, Han J G E; Versluis, Michel; Lohse, Detlef

    2015-02-01

    We study the response of pre-defined cavitation nuclei driven continuously in the kHz regime (80, 100 and 200 kHz). The nuclei consist of stabilized gaspockets in cylindrical pits of 30 μm diameter etched in silicon or glass substrates. It is found that above an acoustic pressure threshold the dynamics of the liquid-gas meniscus switches from a stable drum-like vibration to expansion and deformation, frequently resulting in detachment of microbubbles. Just above this threshold small bubbles are continuously and intermittently ejected. At elevated input powers bubble detachment becomes more frequent and cavitation bubble clouds are formed and remain in the vicinity of the pit bubble. Surprisingly, the resulting loss of gas does not lead to deactivation of the pit which can be explained by a rectified gas diffusion process.

  2. The acoustic emissions of cavitation bubbles in stretched vortices.

    PubMed

    Chang, Natasha A; Ceccio, Steven L

    2011-11-01

    Pairs of unequal strength, counter-rotating vortices were produced in order to examine the inception, dynamics, and acoustic emission of cavitation bubbles in rapidly stretching vortices. The acoustic signatures of these cavitation bubbles were characterized during their inception, growth, and collapse. Growing and collapsing bubbles often produced a sharp, broadband, pop sound. The spectrum of these bubbles, and the peak resonant frequency can generally be related to quiescent flow bubble dynamics and corresponding resonant frequencies. However, some elongated cavitation bubbles produced a short tonal burst, or chirp, with frequencies on the order of a few kilohertz. Theses frequencies are too low to be related to resonant frequencies of a bubble in a quiescent flow. Instead, the frequency content of the acoustic signal during bubble inception and growth is related to the volumetric oscillations of the bubble while it interacted with vortical flow that surrounds the bubble (i.e., the resonant frequency of the vortex-bubble system). A relationship was determined between the observed peak frequency of the oscillations, the highly stretched vortex properties, and the water nuclei content. It was found that different cavitation spectra could relate to different flow and fluid properties and therefore would not scale in the same manner.

  3. Observation of cavitation bubbles and acoustic streaming in high intensity ultrasound fields

    NASA Astrophysics Data System (ADS)

    Uemura, Yuuki; Sasaki, Kazuma; Minami, Kyohei; Sato, Toshio; Choi, Pak-Kon; Takeuchi, Shinichi

    2015-07-01

    We observed the behavior of acoustic cavitation by sonochemical luminescence and ultrasound B-mode imaging with ultrasound diagnostic equipment in a standing-wave ultrasound field and focused ultrasound field. Furthermore, in order to investigate the influence of acoustic streaming on acoustic cavitation bubbles, we performed flow analysis of the sound field using particle image velocimetry. We found that acoustic cavitation bubbles are stirred by circulating acoustic streaming and local vortexes occurring in the water tank of the standing-wave ultrasound exposure system. We considered that the acoustic cavitation bubbles are carried away by acoustic streaming due to the high ultrasound pressure in the focused ultrasound field.

  4. Modeling and experimental analysis of acoustic cavitation bubbles for Burst Wave Lithotripsy

    PubMed Central

    Maeda, Kazuki; Colonius, Tim; Kreider, Wayne; Maxwell, Adam; Cunitz, Bryan; Bailey, Michael

    2016-01-01

    A combined modeling and experimental study of acoustic cavitation bubbles that are initiated by focused ultrasound waves is reported. Focused ultrasound waves of frequency 335 kHz and peak negative pressure 8 MPa are generated in a water tank by a piezoelectric transducer to initiate cavitation. The resulting pressure field is obtained by direct numerical simulation (DNS) and used to simulate single bubble oscillation. The characteristics of cavitation bubbles observed by high-speed photography qualitatively agree withs the simulation result. Finally, bubble clouds are captured using acoustic B-mode imaging that works in synchronization with high-speed photography. PMID:27087826

  5. Numerical simulations of acoustic cavitation noise with the temporal fluctuation in the number of bubbles.

    PubMed

    Yasui, Kyuichi; Tuziuti, Toru; Lee, Judy; Kozuka, Teruyuki; Towata, Atsuya; Iida, Yasuo

    2010-02-01

    Numerical simulations of cavitation noise have been performed under the experimental conditions reported by Ashokkumar et al. (2007) [26]. The results of numerical simulations have indicated that the temporal fluctuation in the number of bubbles results in the broad-band noise. "Transient" cavitation bubbles, which disintegrate into daughter bubbles mostly in a few acoustic cycles, generate the broad-band noise as their short lifetimes cause the temporal fluctuation in the number of bubbles. Not only active bubbles in light emission (sonoluminescence) and chemical reactions but also inactive bubbles generate the broad-band noise. On the other hand, "stable" cavitation bubbles do not generate the broad-band noise. The weaker broad-band noise from a low-concentration surfactant solution compared to that from pure water observed experimentally by Ashokkumar et al. is caused by the fact that most bubbles are shape stable in a low-concentration surfactant solution due to the smaller ambient radii than those in pure water. For a relatively high number density of bubbles, the bubble-bubble interaction intensifies the broad-band noise. Harmonics in cavitation noise are generated by both "stable" and "transient" cavitation bubbles which pulsate nonlinearly with the period of ultrasound.

  6. Effect of static pressure on acoustic energy radiated by cavitation bubbles in viscous liquids under ultrasound.

    PubMed

    Yasui, Kyuichi; Towata, Atsuya; Tuziuti, Toru; Kozuka, Teruyuki; Kato, Kazumi

    2011-11-01

    The effect of static pressure on acoustic emissions including shock-wave emissions from cavitation bubbles in viscous liquids under ultrasound has been studied by numerical simulations in order to investigate the effect of static pressure on dispersion of nano-particles in liquids by ultrasound. The results of the numerical simulations for bubbles of 5 μm in equilibrium radius at 20 kHz have indicated that the optimal static pressure which maximizes the energy of acoustic waves radiated by a bubble per acoustic cycle increases as the acoustic pressure amplitude increases or the viscosity of the solution decreases. It qualitatively agrees with the experimental results by Sauter et al. [Ultrason. Sonochem. 15, 517 (2008)]. In liquids with relatively high viscosity (∼200 mPa s), a bubble collapses more violently than in pure water when the acoustic pressure amplitude is relatively large (∼20 bar). In a mixture of bubbles of different equilibrium radius (3 and 5 μm), the acoustic energy radiated by a 5 μm bubble is much larger than that by a 3 μm bubble due to the interaction with bubbles of different equilibrium radius. The acoustic energy radiated by a 5 μm bubble is substantially increased by the interaction with 3 μm bubbles.

  7. Frequency spectrum of the noise emitted by two interacting cavitation bubbles in strong acoustic fields.

    PubMed

    Jiang, Liang; Liu, Fengbing; Chen, Haosheng; Wang, Jiadao; Chen, Darong

    2012-03-01

    The dynamics and acoustic emission of two interacting cavitation bubbles exposed to strong acoustic fields with a frequency of 515 KHz are investigated numerically in this paper. After comparing the dynamics of a single bubble excited by the given pressure waves, bubbles with ambient radii of 2 and 5 μm were chosen to be studied to discuss the influence of the mutual bubble-bubble interaction on the dynamic behaviors and acoustic emission of the bubbles. The results show that, aside from the external driving pressure waves, the interaction between the bubbles imposes an extra nonlinear effect on the oscillations of the bubbles and that the dynamics of the smaller bubble could be suppressed gradually with the enhancement of this mutual interaction by decreasing the distance between the bubbles. Moreover, the improvement in the oscillation nonlinearity of the bubbles due to the change in the ambient circumstance could readily be observed from the frequency spectra of the bubbles' acoustic emission, which interprets the change by exhibiting an appropriate development of the subharmonics, the ultraharmonics, and the broadband component.

  8. Nonlinear bubble dynamics of cavitation.

    PubMed

    An, Yu

    2012-01-01

    For cavitation clouds generated in a standing sound wave driven by an ultrasonic horn, the nonlinear acoustic wave equation governing cavitation dynamics is numerically solved together with the bubble motion equation under an approximation. This conceptual calculation can qualitatively reproduce the observed characteristics of cavitation.

  9. The penetration of acoustic cavitation bubbles into micrometer-scale cavities.

    PubMed

    Vaidya, Haresh Anant; Ertunç, Özgür; Lichtenegger, Thomas; Delgado, Antonio; Skupin, Andreas

    2016-04-01

    The penetration of acoustically induced cavitation bubbles in micrometer-scale cavities is investigated experimentally by means of high-speed photography and acoustic measurements. Micrometer-scale cavities of different dimensions (width=40 μm, 80 μm, 10 mm and depth=50 μm) are designed to replicate the cross section of microvias in a PCB. The aim here is to present a method for enhancing mass transfer due to the penetration of bubbles in such narrow geometries under the action of ultrasound. The micrometer-scale cavities are placed in a test-cell filled with water and subjected to an ultrasound excitation at 75 kHz. A cavitation bubble cluster is generated at the mouth of the cavity which acts as a continuous source of bubbles that penetrate into the cavity. The radial oscillation characteristics and translation of these bubbles are investigated in detail here. It is observed that the bubbles arrange themselves into streamer-like structures inside the cavity. Parameters such as bubble population and size distribution and their correlation with the phase of the incident ultrasound radiation are investigated in detail here. This provides a valuable insight into the dynamics of bubbles in narrow confined spaces. Mass transfer investigations show that fresh liquid can be continuously introduced in the cavities under the action of ultrasound. Our findings may have important consequences in optimizing the filling processes for microvias with high aspect ratios. PMID:26763751

  10. The penetration of acoustic cavitation bubbles into micrometer-scale cavities.

    PubMed

    Vaidya, Haresh Anant; Ertunç, Özgür; Lichtenegger, Thomas; Delgado, Antonio; Skupin, Andreas

    2016-04-01

    The penetration of acoustically induced cavitation bubbles in micrometer-scale cavities is investigated experimentally by means of high-speed photography and acoustic measurements. Micrometer-scale cavities of different dimensions (width=40 μm, 80 μm, 10 mm and depth=50 μm) are designed to replicate the cross section of microvias in a PCB. The aim here is to present a method for enhancing mass transfer due to the penetration of bubbles in such narrow geometries under the action of ultrasound. The micrometer-scale cavities are placed in a test-cell filled with water and subjected to an ultrasound excitation at 75 kHz. A cavitation bubble cluster is generated at the mouth of the cavity which acts as a continuous source of bubbles that penetrate into the cavity. The radial oscillation characteristics and translation of these bubbles are investigated in detail here. It is observed that the bubbles arrange themselves into streamer-like structures inside the cavity. Parameters such as bubble population and size distribution and their correlation with the phase of the incident ultrasound radiation are investigated in detail here. This provides a valuable insight into the dynamics of bubbles in narrow confined spaces. Mass transfer investigations show that fresh liquid can be continuously introduced in the cavities under the action of ultrasound. Our findings may have important consequences in optimizing the filling processes for microvias with high aspect ratios.

  11. Effect of dissolved gases in water on acoustic cavitation and bubble growth rate in 0.83 MHz megasonic of interest to wafer cleaning.

    PubMed

    Kang, Bong-Kyun; Kim, Min-Su; Park, Jin-Goo

    2014-07-01

    Changes in the cavitation intensity of gases dissolved in water, including H2, N2, and Ar, have been established in studies of acoustic bubble growth rates under ultrasonic fields. Variations in the acoustic properties of dissolved gases in water affect the cavitation intensity at a high frequency (0.83 MHz) due to changes in the rectified diffusion and bubble coalescence rate. It has been proposed that acoustic bubble growth rates rapidly increase when water contains a gas, such as hydrogen faster single bubble growth due to rectified diffusion, and a higher rate of coalescence under Bjerknes forces. The change of acoustic bubble growth rate in rectified diffusion has an effect on the damping constant and diffusivity of gas at the acoustic bubble and liquid interface. It has been suggested that the coalescence reaction of bubbles under Bjerknes forces is a reaction determined by the compressibility and density of dissolved gas in water associated with sound velocity and density in acoustic bubbles. High acoustic bubble growth rates also contribute to enhanced cavitation effects in terms of dissolved gas in water. On the other hand, when Ar gas dissolves into water under ultrasound field, cavitation behavior was reduced remarkably due to its lower acoustic bubble growth rate. It is shown that change of cavitation intensity in various dissolved gases were verified through cleaning experiments in the single type of cleaning tool such as particle removal and pattern damage based on numerically calculated acoustic bubble growth rates.

  12. Cavitation mapping by sonochemiluminescence with less bubble displacement induced by acoustic radiation force in a 1.2 MHz HIFU.

    PubMed

    Yin, Hui; Qiao, Yangzi; Cao, Hua; Li, Zhaopeng; Wan, Mingxi

    2014-03-01

    An acoustic radiation force counterbalanced appliance was employed to map the cavitation distribution in water. The appliance was made up of a focused ultrasound transducer and an aluminum alloy reflector with the exactly same shape. They were centrosymmetry around the focus of the source transducer. Spatial-temporal dynamics of cavitation bubble clouds in the 1.2 MHz ultrasonic field within this appliance were observed in water. And they were mapped by sonochemiluminescence (SCL) recordings and high-speed photography. There were significant differences in spatial distribution and temporal evolution between normal group and counterbalanced group. The reflector could avoid bubble directional displacement induced by acoustic radiation force under certain electric power (≤50 W). As a result, the SCL intensity in the pre-focal region was larger than that of normal group. In event of high electric power (≥70 W), most of the bubbles were moving in acoustic streaming. When electric power decreased, bubbles kept stable and showed stripe structure in SCL images. Both stationary bubbles and moving bubbles have been captured, and exhibited analytical potential with respect to bubbles in therapeutic ultrasound.

  13. Acoustic cavitation movies

    NASA Astrophysics Data System (ADS)

    Crum, Lawrence A.

    2003-04-01

    Acoustic cavitation is a phenomenon that occurs on microsecond time scales and micron length scales, yet, it has many macroscopic manifestations. Accordingly, it is often difficult, at least for the author, to form realistic physical descriptions of the specific mechanisms through which it expresses itself in our macroscopic world. For example, there are still many who believe that cavitation erosion is due to the shock wave that is emitted by bubble implosion, rather than the liquid jet created on asymmetric collapse...and they may be right. Over the years, the author has accumulated a number of movies and high-speed photographs of cavitation activity, which he uses to form his own visual references. In the time allotted, he will show a number of these movies and photographs and discuss their relevance to existing technological problems. A limited number of CDs containing the presented materials will be available to interested individuals. [Work supported in part by the NIH, USAMRMC, and the ONR.

  14. Optical cavitation probe using light scattering from bubble clouds.

    PubMed

    Iida, Yasuo; Lee, Judy; Kozuka, Teruyuki; Yasui, Kyuichi; Towata, Atsuya; Tuziuti, Toru

    2009-04-01

    To understand the behaviour of systems containing clouds of bubbles (multibubble system) in real sonochemical reactors, a new diagnosis method, i.e., optical cavitation probe (OCP), has been proposed. When a laser beam is introduced into the cavitation bubble cloud, the scattered light intensity changes by the collective oscillation of cavitation bubbles. The frequency domain spectrum of the scattered light contains rich information on the cavitation bubble clouds, comparable with the acoustic emission spectra detected by a hydrophone. The significant merits of OCP, such as capability for spatially resolved, non-invasive measurement of the cavitation bubble clouds, robustness even in a violent cavitation field have been experimentally demonstrated.

  15. Effects of an acoustic diode on the pressure waveform and cavitation bubble dynamics produced by a piezoelectric shock wave generator

    NASA Astrophysics Data System (ADS)

    Zhu, Songlin; Zhong, Pei

    2003-10-01

    High-speed schlieren imaging, combined with fiber optical probe hydrophone (FOPH) and passive cavitation detection (PCD) were used to access the effects of an acoustic diode (AD) on the pressure waveform and associated cavitation activities produced by a piezoelectric shock wave (PSW) generator. Without the AD, a typical pressure waveform at the focus of the PSW generator consists of a leading shock wave, followed by a tensile wave and several oscillation waves (OWs) of gradually reduced amplitudes. When the AD was placed 30 mm in front of the focus, the amplitude of the tensile wave was reduced and the subsequent OWs were removed. The pulse intensity integral of the tensile wave was reduced by 58%, and subsequently, PSW-induced bubble dynamics were altered significantly. Based on PCD data, the collapse time of cavitation bubble(s) was reduced by about 11%. Although intensive collapse of microbubbles was observed in about 10 μs following the shock front of the original PSW, the forced collapse of microbubbles was not observed when the AD was used, presumably due to the removal of the OWs. Theoretical calculation based on the Gilmore model confirmed these experimental observations. [Work supported by the Whitaker Foundation and NIH.

  16. Mechanics of collapsing cavitation bubbles.

    PubMed

    van Wijngaarden, Leen

    2016-03-01

    A brief survey is given of the dynamical phenomena accompanying the collapse of cavitation bubbles. The discussion includes shock waves, microjets and the various ways in which collapsing bubbles produce damage.

  17. Bioeffects caused by changes in acoustic cavitation bubble density and cell concentration: a unified explanation based on cell-to-bubble ratio and blast radius.

    PubMed

    Guzmán, Héctor R; McNamara, Andrew J; Nguyen, Daniel X; Prausnitz, Mark R

    2003-08-01

    Acoustic cavitation has been shown to load drugs, proteins and DNA into viable cells as a complex function of acoustic and nonacoustic parameters. To better understand and quantify this functionality, DU145 prostate cancer cell suspensions at different cell concentrations (2.5 x 10(5) to 4.0 x 10(7) cells/mL) were exposed to 500 kHz ultrasound (US) over a range of acoustic energy exposures (2 to 817 J/cm(2); peak negative pressures of 0.64 to 2.96 MPa; exposure times of 120 to 2000 ms) in the presence of different initial concentrations of Optison contrast agent bubbles (3.6 x 10(4) to 9.3 x 10(7) bubbles/mL). As determined by flow cytometry, molecular uptake of calcein and cell viability both increased with increasing cell density; viability decreased and uptake was unaffected by increasing initial contrast agent concentration. When normalized relative to the initial contrast agent concentration (e.g., cells killed per bubble), bioeffects increased with increasing cell density and decreased with increasing bubble concentration. These varying effects of contrast agent concentration and cell density were unified through an overall correlation with cell-to-bubble ratio. Additional analysis led to estimation of "blast radii" over which bubbles killed or permeabilized cells; these radii were as much as 3 to 90 times the bubble radius. Combined, these results suggest that extensive molecular uptake into cells at high viability occurs for low-energy exposure US applied at a high cell-to-bubble ratio.

  18. Theoretical model of ice nucleation induced by inertial acoustic cavitation. Part 2: Number of ice nuclei generated by a single bubble.

    PubMed

    Cogné, C; Labouret, S; Peczalski, R; Louisnard, O; Baillon, F; Espitalier, F

    2016-01-01

    In the preceding paper (part 1), the pressure and temperature fields close to a bubble undergoing inertial acoustic cavitation were presented. It was shown that extremely high liquid water pressures but quite moderate temperatures were attained near the bubble wall just after the collapse providing the necessary conditions for ice nucleation. In this paper (part 2), the nucleation rate and the nuclei number generated by a single collapsing bubble were determined. The calculations were performed for different driving acoustic pressures, liquid ambient temperatures and bubble initial radius. An optimal acoustic pressure range and a nucleation temperature threshold as function of bubble radius were determined. The capability of moderate power ultrasound to trigger ice nucleation at low undercooling level and for a wide distribution of bubble sizes has thus been assessed on the theoretical ground. PMID:26384898

  19. Discrete Bubble Modeling for Cavitation Bubbles

    NASA Astrophysics Data System (ADS)

    Choi, Jin-Keun; Chahine, Georges; Hsiao, Chao-Tsung

    2007-03-01

    Dynaflow, Inc. has conducted extensive studies on non-spherical bubble dynamics and interactions with solid and free boundaries, vortical flow structures, and other bubbles. From these studies, emerged a simplified Surface Averaged Pressure (SAP) spherical bubble dynamics model and a Lagrangian bubble tracking scheme. In this SAP scheme, the pressure and velocity of the surrounding flow field are averaged on the bubble surface, and then used for the bubble motion and volume dynamics calculations. This model is implemented using the Fluent User Defined Function (UDF) as Discrete Bubble Model (DBM). The Bubble dynamics portion can be solved using an incompressible liquid modified Rayleigh-Plesset equation or a compressible liquid modified Gilmore equation. The Discrete Bubble Model is a very suitable tool for the studies on cavitation inception of foils and turbo machinery, bubble nuclei effects, noise from the bubbles, and can be used in many practical problems in industrial and naval applications associated with flows in pipes, jets, pumps, propellers, ships, and the ocean. Applications to propeller cavitation, wake signatures of waterjet propelled ships, bubble-wake interactions, modeling of cavitating jets, and bubble entrainments around a ship will be presented.

  20. Bubble-bubble interaction: A potential source of cavitation noise

    NASA Astrophysics Data System (ADS)

    Ida, Masato

    2009-01-01

    The interaction between microbubbles through pressure pulses has been studied to show that it can be a source of cavitation noise. A recent report demonstrated that the acoustic noise generated by a shrimp originates from the collapse of a cavitation bubble produced when the shrimp closes its snapper claw. The recorded acoustic signal contains a broadband noise that consists of positive and negative pulses, but a theoretical model for single bubbles fails to reproduce the negative ones. Using a nonlinear multibubble model, we have shown here that the negative pulses can be explained by considering the interaction of microbubbles formed after the cavitation bubble has collapsed and fragmented: Positive pulses produced at the collapse of the microbubbles hit and impulsively compress neighboring microbubbles to generate reflected pulses whose amplitudes are negative. Discussing the details of the noise generation process, we have found that no negative pulses are generated if the internal pressure of the reflecting bubble is very high when hit by a positive pulse.

  1. Spatial-temporal dynamics of cavitation bubble clouds in 1.2 MHz focused ultrasound field.

    PubMed

    Chen, Hong; Li, Xiaojing; Wan, Mingxi

    2006-09-01

    Cavitation bubbles have been recognized as being essential to many applications of ultrasound. Temporal evolution and spatial distribution of cavitation bubble clouds induced by a focused ultrasound transducer of 1.2 MHz center frequency are investigated by high-speed photography. It is revealed that at a total acoustic power of 72 W the cavitation bubble cloud first emerges in the focal region where cavitation bubbles are observed to generate, grow, merge and collapse during the initial 600 micros. The bubble cloud then grows upward to the post-focal region, and finally becomes visible in the pre-focal region. The structure of the final bubble cloud is characterized by regional distribution of cavitation bubbles in the ultrasound field. The cavitation bubble cloud structure remains stable when the acoustic power is increased from 25 W to 107 W, but it changes to a more violent form when the acoustic power is further increased to 175 W.

  2. Spatial-temporal dynamics of cavitation bubble clouds in 1.2 MHz focused ultrasound field.

    PubMed

    Chen, Hong; Li, Xiaojing; Wan, Mingxi

    2006-09-01

    Cavitation bubbles have been recognized as being essential to many applications of ultrasound. Temporal evolution and spatial distribution of cavitation bubble clouds induced by a focused ultrasound transducer of 1.2 MHz center frequency are investigated by high-speed photography. It is revealed that at a total acoustic power of 72 W the cavitation bubble cloud first emerges in the focal region where cavitation bubbles are observed to generate, grow, merge and collapse during the initial 600 micros. The bubble cloud then grows upward to the post-focal region, and finally becomes visible in the pre-focal region. The structure of the final bubble cloud is characterized by regional distribution of cavitation bubbles in the ultrasound field. The cavitation bubble cloud structure remains stable when the acoustic power is increased from 25 W to 107 W, but it changes to a more violent form when the acoustic power is further increased to 175 W. PMID:16571378

  3. On thermonuclear processes in cavitation bubbles

    NASA Astrophysics Data System (ADS)

    Nigmatulin, R. I.; Lahey, R. T., Jr.; Taleyarkhan, R. P.; West, C. D.; Block, R. C.

    2014-09-01

    The theoretical and experimental foundations of so-called bubble nuclear fusion are reviewed. In the nuclear fusion process, a spherical cavitation cluster ˜ 10-2 m in diameter is produced of spherical bubbles at the center of a cylindrical chamber filled with deuterated acetone using a focused acoustic field having a resonant frequency of about 20 kHz. The acoustically-forced bubbles effectuate volume oscillations with sharp collapses during the compression stage. At the final stages of collapse, the bubble cluster emits 2.5 MeV D-D fusion neutron pulses at a rate of ˜ 2000 per second. The neutron yield is ˜ 10^5 s -1. In parallel, tritium nuclei are produced at the same yield. It is shown numerically that, for bubbles having sufficient molecular mass, spherical shock waves develop in the center of the cluster and that these spherical shock waves (microshocks) produce converging shocks within the interior bubbles, which focus energy on the centers of the bubbles. When these shock waves reflect from the centers of the bubbles, extreme conditions of temperature ( ˜ 10^8 K) and density ( ˜ 10^4 kg m -3) arise in a (nano)spherical region ( ˜ 10-7 m in size) that last for ˜ 10-12 s, during which time about ten D-D fusion neutrons and tritium nuclei are produced in the region. A paradoxical result in our experiments is that it is bubble cluster (not streamer) cavitation and the sufficiently high molecular mass of (and hence the low sound speed in) D-acetone ( C3D6O) vapor (as compared, for example, to deuterated water D2O) which are necessary conditions for the formation of convergent spherical microshock waves in central cluster bubbles. It is these waves that allow the energy to be sufficiently focused in the nanospherical regions near the bubble centers for fusion events to occur. The criticism to which the concept of 'bubble fusion' has been subjected in the literature, in particular, most recently in Uspekhi Fizicheskikh Nauk (Physics - Uspekhi) journal, is

  4. Cavitation inception from bubble nuclei

    PubMed Central

    Mørch, K. A.

    2015-01-01

    The tensile strength of ordinary water such as tap water or seawater is typically well below 1 bar. It is governed by cavitation nuclei in the water, not by the tensile strength of the water itself, which is extremely high. Different models of the nuclei have been suggested over the years, and experimental investigations of bubbles and cavitation inception have been presented. These results suggest that cavitation nuclei in equilibrium are gaseous voids in the water, stabilized by a skin which allows diffusion balance between gas inside the void and gas in solution in the surrounding liquid. The cavitation nuclei may be free gas bubbles in the bulk of water, or interfacial gaseous voids located on the surface of particles in the water, or on bounding walls. The tensile strength of these nuclei depends not only on the water quality but also on the pressure–time history of the water. A recent model and associated experiments throw new light on the effects of transient pressures on the tensile strength of water, which may be notably reduced or increased by such pressure changes. PMID:26442138

  5. Sonoporation from Jetting Cavitation Bubbles

    PubMed Central

    Ohl, Claus-Dieter; Arora, Manish; Ikink, Roy; de Jong, Nico; Versluis, Michel; Delius, Michael; Lohse, Detlef

    2006-01-01

    The fluid dynamic interaction of cavitation bubbles with adherent cells on a substrate is experimentally investigated. We find that the nonspherical collapse of bubbles near to the boundary is responsible for cell detachment. High-speed photography reveals that a wall bounded flow leads to the detachment of cells. Cells at the edge of the circular area of detachment are found to be permanently porated, whereas cells at some distance from the detachment area undergo viable cell membrane poration (sonoporation). The wall flow field leading to cell detachment is modeled with a self-similar solution for a wall jet, together with a kinetic ansatz of adhesive bond rupture. The self-similar solution for the δ-type wall jet compares very well with the full solution of the Navier-Stokes equation for a jet of finite thickness. Apart from annular sites of sonoporation we also find more homogenous patterns of molecule delivery with no cell detachment. PMID:16950843

  6. Acoustic bubble removal method

    NASA Technical Reports Server (NTRS)

    Trinh, E. H.; Elleman, D. D.; Wang, T. G. (Inventor)

    1983-01-01

    A method is described for removing bubbles from a liquid bath such as a bath of molten glass to be used for optical elements. Larger bubbles are first removed by applying acoustic energy resonant to a bath dimension to drive the larger bubbles toward a pressure well where the bubbles can coalesce and then be more easily removed. Thereafter, submillimeter bubbles are removed by applying acoustic energy of frequencies resonant to the small bubbles to oscillate them and thereby stir liquid immediately about the bubbles to facilitate their breakup and absorption into the liquid.

  7. Numerical simulation of cavitation bubble dynamics induced by ultrasound waves in a high frequency reactor.

    PubMed

    Servant, G; Caltagirone, J P; Gérard, A; Laborde, J L; Hita, A

    2000-10-01

    The use of high frequency ultrasound in chemical systems is of major interest to optimize chemical procedures. Characterization of an open air 477 kHz ultrasound reactor shows that, because of the collapse of transient cavitation bubbles and pulsation of stable cavitation bubbles, chemical reactions are enhanced. Numerical modelling is undertaken to determine the spatio-temporal evolution of cavitation bubbles. The calculus of the emergence of cavitation bubbles due to the acoustic driving (by taking into account interactions between the sound field and bubbles' distribution) gives a cartography of bubbles' emergence within the reactor. Computation of their motion induced by the pressure gradients occurring in the reactor show that they migrate to the pressure nodes. Computed bubbles levitation sites gives a cartography of the chemical activity of ultrasound. Modelling of stable cavitation bubbles' motion induced by the motion of the liquid gives some insight on degassing phenomena. PMID:11062879

  8. Cavitation inception by the backscattering of pressure waves from a bubble interface

    NASA Astrophysics Data System (ADS)

    Takahira, Hiroyuki; Ogasawara, Toshiyuki; Mori, Naoto; Tanaka, Moe

    2015-10-01

    The secondary cavitation that occurs by the backscattering of focused ultrasound from a primary cavitation bubble caused by the negative pressure part of the ultrasound (Maxwell, et al., 2011) might be useful for the energy exchange due to bubble oscillations in High Intensity Focused Ultrasound (HIFU). The present study is concerned with the cavitation inception by the backscattering of ultrasound from a bubble. In the present experiment, a laser-induced bubble which is generated by a pulsed focused laser beam with high intensity is utilized as a primary cavitation bubble. After generating the bubble, focused ultrasound is emitted to the bubble. The acoustic field and the bubble motion are observed with a high-speed video camera. It is confirmed that the secondary cavitation bubble clouds are generated by the backscattering from the laser-induced bubble. The growth of cavitation bubble clouds is analyzed with the image processing method. The experimental results show that the height and width of the bubble clouds grow in stepwise during their evolution. The direct numerical simulations are also conducted for the backscattering of incident pressure waves from a bubble in order to evaluate a pressure field near the bubble. It is shown that the ratio of a bubble collapse time t0 to a characteristic time of wave propagation tS, η = t0/ts, is an important determinant for generating negative pressure region by backscattering. The minimum pressure location by the backscattering in simulations is in good agreement with the experiment.

  9. Acoustic cavitation generated by an extracorporeal shockwave lithotripter.

    PubMed

    Coleman, A J; Saunders, J E; Crum, L A; Dyson, M

    1987-02-01

    Evidence is presented of acoustic cavitation generated by a Dornier extracorporeal shockwave lithotripter. Using x-ray film, thin aluminum sheets, and relatively thick metal plates as targets, evidence of liquid jet impacts associated with cavitation bubble collapse was observed. The jet impact was violent enough to puncture thin foils and deform metal plates. Furthermore, numerous jet impacts were generated over a volume of greater than 200 cm3. It is likely that such violent cavitation will also occur in tissue, and observed biological effects (e.g. renal calculus disintegration and tissue trauma) may be related to cavitation damage.

  10. Visualization of acoustic cavitation effects on suspended calcite crystals.

    PubMed

    Wagterveld, R M; Boels, L; Mayer, M J; Witkamp, G J

    2011-01-01

    The acoustic cavitation (42,080 Hz, 7.1 W cm(-2) or 17 W) effects on suspended calcite crystals, sized between 5 and 50 μm, have been visualized for the first time using high speed photography. High speed recordings with a duration of 1 s containing up to 300,000 frames per second, revealed the effect of cluster and streamer cavitation on several calcite crystals. Cavitation clusters, evolved from cavitation inception and collapse, caused attrition, disruption of aggregates and deagglomeration, whereas streamer cavitation was observed to cause deagglomeration only. Cavitation on the surface gave the crystals momentum. However, it is shown that breakage of accelerated crystals by interparticle collisions is unrealistic because of their small sizes and low velocities. Crystals that were accelerated by bubble expansion, subsequently experienced a deceleration much stronger than expected from drag forces, upon bubble collapse. Experiments with pre-dried crystals seemed to support the current theory on bubble nucleation through the presence of pre-existing gas pockets. However, experiments with fully wetted crystals also showed the nucleation of bubbles on the crystal surface. Although microjet impingement on the crystal surface could not be directly visualized with high speed photography, scanning electron microscopy (SEM) analysis of irradiated calcite seeds showed deep circular indentations. It was suggested that these indentations might be caused by shockwave induced jet impingement. Furthermore, the appearance of voluminous fragments with large planes of fracture indicated that acoustic cavitation can also cause the breakage of single crystal structures.

  11. Sonoluminescence, sonochemistry and bubble dynamics of single bubble cavitation

    NASA Astrophysics Data System (ADS)

    Hatanaka, Shin-ichi

    2012-09-01

    The amount of hydroxyl radicals produced from a single cavitation bubble was quantified by terephthalate dosimetry at various frequencies and pressure amplitudes, while the dynamics of the single bubble was observed by stroboscopic and light-scattering methods. Also, sonoluminescence (SL), sonochemiluminescence (SCL) of luminol, and sodium atom emission (Na*) in the cavitation field were observed. The amount of hydroxyl radicals per cycle as well as the intensity of SL was proportional to pressure amplitude at every frequency performed, and it decreased with increasing frequency. When the single bubble was dancing with a decrease in pressure amplitude, however, the amount of hydroxyl radicals was greater than that for the stable bubble at the higher pressure amplitude and did not significantly decrease with frequency. Furthermore, SCL and Na* were detected only under unstable bubble conditions. These results imply that the instability of bubbles significantly enhances sonochemical efficiency for non-volatile substances in liquid phase.

  12. Quantitative assessment of reactive oxygen sonochemically generated by cavitation bubbles

    NASA Astrophysics Data System (ADS)

    Yasuda, Jun; Miyashita, Takuya; Taguchi, Kei; Yoshizawa, Shin; Umemura, Shin-ichiro

    2015-07-01

    Acoustic cavitation bubbles can induce not only a thermal bioeffect but also a chemical bioeffect. When cavitation bubbles collapse and oscillate violently, they produce reactive oxygen species (ROS) that cause irreversible changes to the tissue. A sonosensitizer can promote such ROS generation. A treatment method using a sonosensitizer is called sonodynamic treatment. Rose bengal (RB) is one of the sonosensitizers whose in vivo and in vitro studies have been reported. In sonodynamic treatment, it is important to produce ROS at a high efficiency. For the efficient generation of ROS, a triggered high-intensity focused ultrasound (HIFU) sequence has been proposed. In this study, cavitation bubbles were generated in a chamber where RB solution was sealed, and a high-speed camera captured the behavior of these cavitation bubbles. The amount of ROS was also quantified by a potassium iodide (KI) method and compared with high-speed camera pictures to investigate the effectiveness of the triggered HIFU sequence. As a result, ROS could be obtained efficiently by this sequence.

  13. Analysis of cavitation bubble dynamics in a liquid

    NASA Technical Reports Server (NTRS)

    Fontenot, L. L.; Lee, Y. C.

    1971-01-01

    General differential equations governing the dynamics of the cavitation bubbles in a liquid were derived. With the assumption of spherical symmetry the governing equations were simplified. Closed form solutions were obtained for simple cases, and numerical solutions were calculated for complicated ones. The growth and the collapse of the bubble were analyzed, oscillations of the bubbles were studied, and the stability of the cavitation bubbles were investigated. The results show that the cavitation bubbles are unstable, and the oscillation is not sinusoidal.

  14. Intensely oscillating cavitation bubble in microfluidics

    NASA Astrophysics Data System (ADS)

    Siew-Wan, Ohl; Tandiono; Klaseboer, Evert; Dave, Ow; Choo, Andre; Claus-Dieter, Ohl

    2015-12-01

    This study reports the technical breakthrough in generating intense ultrasonic cavitation in the confinement of a microfluidics channel [1], and applications that has been developed on this platform for the past few years [2,3,4,5]. Our system consists of circular disc transducers (10-20 mm in diameter), the microfluidics channels on PDMS (polydimethylsiloxane), and a driving circuitry. The cavitation bubbles are created at the gas- water interface due to strong capillary waves which are generated when the system is driven at its natural frequency (around 100 kHz) [1]. These bubbles oscillate and collapse within the channel. The bubbles are useful for sonochemistry and the generation of sonoluminescence [2]. When we add bacteria (Escherichia coli), and yeast cells (Pichia pastoris) into the microfluidics channels, the oscillating and collapsing bubbles stretch and lyse these cells [3]. Furthermore, the system is effective (DNA of the harvested intracellular content remains largely intact), and efficient (yield reaches saturation in less than 1 second). In another application, human red blood cells are added to a microchamber. Cell stretching and rapture are observed when a laser generated cavitation bubble expands and collapses next to the cell [4]. A numerical model of a liquid pocket surrounded by a membrane with surface tension which was placed next to an oscillating bubble was developed using the Boundary Element Method. The simulation results showed that the stretching of the liquid pocket occurs only when the surface tension is within a certain range.

  15. Nucleus factory on cavitation bubble for amyloid β fibril

    PubMed Central

    Nakajima, Kichitaro; Ogi, Hirotsugu; Adachi, Kanta; Noi, Kentaro; Hirao, Masahiko; Yagi, Hisashi; Goto, Yuji

    2016-01-01

    Structural evolution from monomer to fibril of amyloid β peptide is related to pathogenic mechanism of Alzheimer disease, and its acceleration is a long-running problem in drug development. This study reveals that ultrasonic cavitation bubbles behave as catalysts for nucleation of the peptide: The nucleation reaction is highly dependent on frequency and pressure of acoustic wave, and we discover an optimum acoustical condition, at which the reaction-rate constant for nucleation is increased by three-orders-of magnitudes. A theoretical model is proposed for explaining highly frequency and pressure dependent nucleation reaction, where monomers are captured on the bubble surface during its growth and highly condensed by subsequent bubble collapse, so that they are transiently exposed to high temperatures. Thus, the dual effects of local condensation and local heating contribute to dramatically enhance the nucleation reaction. Our model consistently reproduces the frequency and pressure dependences, supporting its essential applicability. PMID:26912021

  16. Nucleus factory on cavitation bubble for amyloid β fibril.

    PubMed

    Nakajima, Kichitaro; Ogi, Hirotsugu; Adachi, Kanta; Noi, Kentaro; Hirao, Masahiko; Yagi, Hisashi; Goto, Yuji

    2016-01-01

    Structural evolution from monomer to fibril of amyloid β peptide is related to pathogenic mechanism of Alzheimer disease, and its acceleration is a long-running problem in drug development. This study reveals that ultrasonic cavitation bubbles behave as catalysts for nucleation of the peptide: The nucleation reaction is highly dependent on frequency and pressure of acoustic wave, and we discover an optimum acoustical condition, at which the reaction-rate constant for nucleation is increased by three-orders-of magnitudes. A theoretical model is proposed for explaining highly frequency and pressure dependent nucleation reaction, where monomers are captured on the bubble surface during its growth and highly condensed by subsequent bubble collapse, so that they are transiently exposed to high temperatures. Thus, the dual effects of local condensation and local heating contribute to dramatically enhance the nucleation reaction. Our model consistently reproduces the frequency and pressure dependences, supporting its essential applicability. PMID:26912021

  17. Nucleus factory on cavitation bubble for amyloid β fibril.

    PubMed

    Nakajima, Kichitaro; Ogi, Hirotsugu; Adachi, Kanta; Noi, Kentaro; Hirao, Masahiko; Yagi, Hisashi; Goto, Yuji

    2016-02-25

    Structural evolution from monomer to fibril of amyloid β peptide is related to pathogenic mechanism of Alzheimer disease, and its acceleration is a long-running problem in drug development. This study reveals that ultrasonic cavitation bubbles behave as catalysts for nucleation of the peptide: The nucleation reaction is highly dependent on frequency and pressure of acoustic wave, and we discover an optimum acoustical condition, at which the reaction-rate constant for nucleation is increased by three-orders-of magnitudes. A theoretical model is proposed for explaining highly frequency and pressure dependent nucleation reaction, where monomers are captured on the bubble surface during its growth and highly condensed by subsequent bubble collapse, so that they are transiently exposed to high temperatures. Thus, the dual effects of local condensation and local heating contribute to dramatically enhance the nucleation reaction. Our model consistently reproduces the frequency and pressure dependences, supporting its essential applicability.

  18. Nucleus factory on cavitation bubble for amyloid β fibril

    NASA Astrophysics Data System (ADS)

    Nakajima, Kichitaro; Ogi, Hirotsugu; Adachi, Kanta; Noi, Kentaro; Hirao, Masahiko; Yagi, Hisashi; Goto, Yuji

    2016-02-01

    Structural evolution from monomer to fibril of amyloid β peptide is related to pathogenic mechanism of Alzheimer disease, and its acceleration is a long-running problem in drug development. This study reveals that ultrasonic cavitation bubbles behave as catalysts for nucleation of the peptide: The nucleation reaction is highly dependent on frequency and pressure of acoustic wave, and we discover an optimum acoustical condition, at which the reaction-rate constant for nucleation is increased by three-orders-of magnitudes. A theoretical model is proposed for explaining highly frequency and pressure dependent nucleation reaction, where monomers are captured on the bubble surface during its growth and highly condensed by subsequent bubble collapse, so that they are transiently exposed to high temperatures. Thus, the dual effects of local condensation and local heating contribute to dramatically enhance the nucleation reaction. Our model consistently reproduces the frequency and pressure dependences, supporting its essential applicability.

  19. A Study of Cavitation-Ignition Bubble Combustion

    NASA Technical Reports Server (NTRS)

    Nguyen, Quang-Viet; Jacqmin, David A.

    2005-01-01

    We present the results of an experimental and computational study of the physics and chemistry of cavitation-ignition bubble combustion (CIBC), a process that occurs when combustible gaseous mixtures are ignited by the high temperatures found inside a rapidly collapsing bubble. The CIBC process was modeled using a time-dependent compressible fluid-dynamics code that includes finite-rate chemistry. The model predicts that gas-phase reactions within the bubble produce CO and other gaseous by-products of combustion. In addition, heat and mechanical energy release through a bubble volume-expansion phase are also predicted by the model. We experimentally demonstrate the CIBC process using an ultrasonically excited cavitation flow reactor with various hydrocarbon-air mixtures in liquid water. Low concentrations (< 160 ppm) of carbon monoxide (CO) emissions from the ultrasonic reactor were measured, and found to be proportional to the acoustic excitation power. The results of the model were consistent with the measured experimental results. Based on the experimental findings, the computational model, and previous reports of the "micro-diesel effect" in industrial hydraulic systems, we conclude that CIBC is indeed possible and exists in ultrasonically- and hydrodynamically-induced cavitation. Finally, estimates of the utility of CIBC process as a means of powering an idealized heat engine are also presented.

  20. How Snapping Shrimp Snap: Through Cavitating Bubbles

    NASA Astrophysics Data System (ADS)

    Versluis, Michel; Schmitz, Barbara; von der Heydt, Anna; Lohse, Detlef

    2000-09-01

    The snapping shrimp (Alpheus heterochaelis) produces a loud snapping sound by an extremely rapid closure of its snapper claw. One of the effects of the snapping is to stun or kill prey animals. During the rapid snapper claw closure, a high-velocity water jet is emitted from the claw with a speed exceeding cavitation conditions. Hydrophone measurements in conjunction with time-controlled high-speed imaging of the claw closure demonstrate that the sound is emitted at the cavitation bubble collapse and not on claw closure. A model for the bubble dynamics based on a Rayleigh-Plesset-type equation quantitatively accounts for the time dependence of the bubble radius and for the emitted sound.

  1. Mixture segregation by an inertial cavitation bubble.

    PubMed

    Grossier, R; Louisnard, O; Vargas, Y

    2007-04-01

    Pressure diffusion is a mass diffusion process forced by pressure gradients. It has the ability to segregate two species of a mixture, driving the densest species toward high pressure zones, but requires very large pressure gradients to become noticeable. An inertial cavitation bubble develops large pressure gradients in its vicinity, especially as the bubble rebounds at the end of its collapse, and it is therefore expected that a liquid mixture surrounding such a bubble would become segregated. Theory developed in an earlier paper shows that this is indeed the case for sufficiently large molecules or nano-particles. The main theoretical results are recalled and a possible implication of this segregation phenomenon on the well-known cavitation-enhanced crystals nucleation is proposed.

  2. Multiscale Modeling of Cavitating Bubbly Flows

    NASA Astrophysics Data System (ADS)

    Ma, J.; Hsiao, C.-T.; Chahine, G. L.

    2013-03-01

    Modeling of cavitating bubbly flows is challenging due to the wide range of characteristic lengths of the physics at play: from micrometers (e.g., bubble nuclei radius) to meters (e.g., propeller diameter or sheet cavity length). To address this, we present here a multiscale approach which integrates a Discrete Bubble Model for dispersed microbubbles and a level set N-S solver for macro cavities, along with a mesoscale transition model to bridge the two. This approach was implemented in 3DYNAFScopyright and used to simulate sheet-to-cloud cavitation over a hydrofoil. The hybrid model captures well the full cavitation process starting from free field nuclei and nucleation from solid surfaces. In low pressure region of the foil small nuclei are seen to grow large and eventually merge to form a large scale sheet cavity. A reentrant jet forms under the cavity, travels upstream, and breaks it, resulting in a bubble cloud of a large amount of microbubbles as the broken pockets shrink and travel downstream. This is in good agreement with experimental observations based of sheet lengths and frequency of lift force oscillation. DOE-SBIR, ONR (monitored by Dr. Ki-Han Kim)

  3. Cavitation inception by the backscattering of pressure waves from a bubble interface

    SciTech Connect

    Takahira, Hiroyuki Ogasawara, Toshiyuki Mori, Naoto Tanaka, Moe

    2015-10-28

    The secondary cavitation that occurs by the backscattering of focused ultrasound from a primary cavitation bubble caused by the negative pressure part of the ultrasound (Maxwell, et al., 2011) might be useful for the energy exchange due to bubble oscillations in High Intensity Focused Ultrasound (HIFU). The present study is concerned with the cavitation inception by the backscattering of ultrasound from a bubble. In the present experiment, a laser-induced bubble which is generated by a pulsed focused laser beam with high intensity is utilized as a primary cavitation bubble. After generating the bubble, focused ultrasound is emitted to the bubble. The acoustic field and the bubble motion are observed with a high-speed video camera. It is confirmed that the secondary cavitation bubble clouds are generated by the backscattering from the laser-induced bubble. The growth of cavitation bubble clouds is analyzed with the image processing method. The experimental results show that the height and width of the bubble clouds grow in stepwise during their evolution. The direct numerical simulations are also conducted for the backscattering of incident pressure waves from a bubble in order to evaluate a pressure field near the bubble. It is shown that the ratio of a bubble collapse time t{sub 0} to a characteristic time of wave propagation t{sub S}, η = t{sub 0}/t{sub s}, is an important determinant for generating negative pressure region by backscattering. The minimum pressure location by the backscattering in simulations is in good agreement with the experiment.

  4. Cavitation clouds created by shock scattering from bubbles during histotripsy.

    PubMed

    Maxwell, Adam D; Wang, Tzu-Yin; Cain, Charles A; Fowlkes, J Brian; Sapozhnikov, Oleg A; Bailey, Michael R; Xu, Zhen

    2011-10-01

    Histotripsy is a therapy that focuses short-duration, high-amplitude pulses of ultrasound to incite a localized cavitation cloud that mechanically breaks down tissue. To investigate the mechanism of cloud formation, high-speed photography was used to observe clouds generated during single histotripsy pulses. Pulses of 5-20 cycles duration were applied to a transparent tissue phantom by a 1-MHz spherically focused transducer. Clouds initiated from single cavitation bubbles that formed during the initial cycles of the pulse, and grew along the acoustic axis opposite the propagation direction. Based on these observations, we hypothesized that clouds form as a result of large negative pressure generated by the backscattering of shockwaves from a single bubble. The positive-pressure phase of the wave inverts upon scattering and superimposes on the incident negative-pressure phase to create this negative pressure and cavitation. The process repeats with each cycle of the incident wave, and the bubble cloud elongates toward the transducer. Finite-amplitude propagation distorts the incident wave such that the peak-positive pressure is much greater than the peak-negative pressure, which exaggerates the effect. The hypothesis was tested with two modified incident waves that maintained negative pressure but reduced the positive pressure amplitude. These waves suppressed cloud formation which supported the hypothesis.

  5. Mechanoluminescence and sonoluminescence from acoustic cavitation

    NASA Astrophysics Data System (ADS)

    Eddingsaas, Nathan C.

    The intense shock wave launched from collapsing bubbles during the sonication of slurries allows for the study of chemical and physical events that occur when a solid is stressed or fractured. One such event is mechanoluminescence (ML): light produced by any mechanical action on a solid. ML has been studied for over 400 years, but much is still not known about it because the emission is inherently weak. Sonicating slurries of mechanoluminescent crystals (such as sucrose, sodium chloride, resorcinol, m-aminophenol, or coumarin) in long chain alkanes has produced very bright ML, up to 1,000 fold more intense than from manual grinding. The large increase in intensity has revealed a number of new emitting species including C2, CH, CO, CO+, CO2+, H, and He+, many of which have not been reported from ML before. In addition, the emission products show that gas phase reactions are occurring within the plasma generated from the ML discharge. The intense ML induced by acoustic cavitation allowed the plasma to be characterized in terms of heavy atom temperature of ˜400 K, electron density of 1014 cm-1, and electron energy of ˜3.5 eV. These conditions are very similar to other highly reactive microdischarges. To further extend the knowledge of the conditions generated within a cloud of cavitating bubbles, multi-bubble sonoluminescence (MBSL) of sulfuric acid has been studied. The MBSL spectrum from 95 wt % H2SO 4 consists of a broad continuum extending into the UV with SO and Ar emission lines also observed. The Ar lines were used to determine an effective emission temperature of ˜8,000 K, which is substantially greater than in other low vapor pressure systems (e.g., silicone oil, where MBSL emission temperature is only ˜5,000 K). The observation of Ar lines at this temperature also indicates that a hot plasma core is probably generated during multi-bubble cavitation in sulfuric acid. In addition, the effect of solution composition was studied by varying the acid

  6. Cavitation of electron bubbles in liquid parahydrogen

    NASA Astrophysics Data System (ADS)

    Ancilotto, Francesco; Barranco, Manuel; Navarro, Jesús; Pi, Martí

    2011-12-01

    Within a finite-temperature density functional approach, we have investigated the structure of electron bubbles in liquid parahydrogen below the saturated vapour pressure, determining the critical pressure at which electron bubbles explode as a function of temperature. The electron-parahydrogen interaction has been modelled by a Hartree-type local potential fitted to the experimental value of the conduction band-edge for a delocalized electron in pH2. We have found that the pressure for bubble explosion is, in absolute value, about a factor of two smaller than that of the homogeneous cavitation pressure in the liquid. Comparison with the results obtained within the capillary model shows the limitations of this approximation, especially as temperature increases.

  7. Cloud cavitation induced by shock-bubble interaction in a viscoelastic solid

    NASA Astrophysics Data System (ADS)

    Oguri, Ryota; Ando, Keita

    2015-12-01

    We experimentally study a shock-bubble interaction problem in a viscoelastic solid, which is relevant to shock wave lithotripsy. A gas bubble is produced by focusing an infrared laser pulse into gelatin. A spherical shock is then created, through rapid expansion of plasma that results from the laser focusing, in the vicinity of the gas bubble. The shock-bubble interaction is recorded by a CCD camera with flash illumination of a nanosecond green laser pulse. The observation captures cavitation inception in the gelatin under tension that results from acoustic impedance mismatching at the bubble wall. Namely, the shock reflects at the bubble interface as a rarefaction wave, which induces the nucleation of cavitation bubbles as a result of rupturing the gelatin.

  8. A two-dimensional nonlinear model for the generation of stable cavitation bubbles.

    PubMed

    Vanhille, Christian

    2016-07-01

    Bubbles appear by acoustic cavitation in a liquid when rarefaction pressures attain a specific threshold value in a liquid. Once they are created, the stable cavitation bubbles oscillate nonlinearly and affect the ultrasonic field. Here we present a model developed for the study of bubble generation in a liquid contained in a two-dimensional cavity in which a standing ultrasonic field is established. The model considers dissipation and dispersion due to the bubbles. It also assumes that both the ultrasonic field and the bubble oscillations are nonlinear. The numerical experiments predict where the bubbles are generated from a population of nuclei distributed in the liquid and show how they affect the ultrasonic field. PMID:26964990

  9. A two-dimensional nonlinear model for the generation of stable cavitation bubbles.

    PubMed

    Vanhille, Christian

    2016-07-01

    Bubbles appear by acoustic cavitation in a liquid when rarefaction pressures attain a specific threshold value in a liquid. Once they are created, the stable cavitation bubbles oscillate nonlinearly and affect the ultrasonic field. Here we present a model developed for the study of bubble generation in a liquid contained in a two-dimensional cavity in which a standing ultrasonic field is established. The model considers dissipation and dispersion due to the bubbles. It also assumes that both the ultrasonic field and the bubble oscillations are nonlinear. The numerical experiments predict where the bubbles are generated from a population of nuclei distributed in the liquid and show how they affect the ultrasonic field.

  10. Cavitation bubble generation and control for HIFU transcranial adaptive focusing

    NASA Astrophysics Data System (ADS)

    Gâteau, J.; Marsac, L.; Pernot, M.; Aubry, J.-F.; Tanter, M.; Fink, M.

    2009-04-01

    Brain treatment with High Intensity Focused Ultrasound (HIFU) can be achieved by multichannel arrays through the skull using time-reversal focusing. Such a method requires a reference signal either sent by a real source embedded in brain tissues or computed from a virtual source, using the acoustic properties of the skull deduced from CT images. This noninvasive computational method allows precise focusing, but is time consuming and suffers from unavoidable modeling errors which reduce the accessible acoustic pressure at the focus in comparison with real experimental time-reversal using an implanted hydrophone. Ex vivo simulations with a half skull immersed in a water tank allow us to reach at low amplitude levels a pressure ratio of 83% of the reference pressure (real time reversal) at 1MHz. Using this method to transcranially focus a pulse signal in an agar gel (model for in vivo bubble formation), we induced a cavitation bubble that generated an ultrasonic wave received by the array. Selecting the 1MHz component, the signal was time reversed and re-emitted, allowing 97%±1.1% of pressure ratio to be restored. To target points in the vicinity of the geometrical focus, electronic steering from the reference signal has been achieved. Skull aberrations severely degrade the accessible pressure while moving away from the focus ( ˜90% at 10mm in the focal plane). Nevertheless, inducing cavitation bubbles close to the limit of the primary accessible zone allowed us to acquire multiple references signal to increase the electronic steering area by 50%.

  11. Cavitation Bubble Nucleation by Energetic Particles

    SciTech Connect

    West, C.D.

    1998-12-01

    In the early sixties, experimental measurements using a bubble chamber confirmed quantitatively the thermal spike theory of bubble nucleation by energetic particles: the energy of the slow, heavy alpha decay recoils used in those experiments matched the calculated bubble nucleation energy to within a few percent. It was a triumph, but was soon to be followed by a puzzle. Within a couple of years, experiments on similar liquids, but well below their normal boiling points, placed under tensile stress showed that the calculated bubble nucleation energy was an order of magnitude less than the recoil energy. Why should the theory work so well in the one case and so badly in the other? How did the liquid, or the recoil particle, "know" the difference between the two experiments? Another mathematical model of the same physical process, introduced in 1967, showed qualitatively why different analyses would be needed for liquids with high and low vapor pressures under positive or negative pressures. But, the quantitative agreement between the calculated nucleation energy and the recoil energy was still poor--the former being smaller by a factor of two to three. In this report, the 1967 analysis is extended and refined: the qualitative understanding of the difference between positive and negative pressure nucleation, "boiling" and "cavitation" respectively, is retained, and agreement between the negative pressure calculated to be needed for nucleation and the energy calculated to be available is much improved. A plot of the calculated negative pressure needed to induce bubble formation against the measured value now has a slope of 1.0, although there is still considerable scatter in the individual points.

  12. Observation of bubble dynamics within luminescent cavitation clouds: Sonoluminescence at the nano-scale.

    PubMed

    Weninger, K R; Camara, C G; Putterman, S J

    2001-01-01

    Measurements of acoustically driven cavitation luminescence indicate that this phenomenon is robust over a huge parameter space ranging from 10 kHz to >10 MHz. The minimum bubble radius achieved is an upper bound for the size of the light-emitting region and ranges from about 1 microm at 15 kHz to tens of nm at 11 MHz. Although lines can be discerned in the spectra of some cavitation clouds, they sit on top of a broadband continuum which can have greater spectral density in the ultraviolet than is observed for resonantly driven sonoluminescence from a single bubble.

  13. High speed imaging of bubble clouds generated in pulsed ultrasound cavitational therapy--histotripsy.

    PubMed

    Xu, Zhen; Raghavan, Mekhala; Hall, Timothy L; Chang, Ching-Wei; Mycek, Mary-Ann; Fowlkes, J Brian; Cain, Charles A

    2007-10-01

    Our recent studies have demonstrated that mechanical fractionation of tissue structure with sharply demarcated boundaries can be achieved using short (< 20 micros), high intensity ultrasound pulses delivered at low duty cycles. We have called this technique histotripsy. Histotripsy has potential clinical applications where noninvasive tissue fractionation and/or tissue removal are desired. The primary mechanism of histotripsy is thought to be acoustic cavitation, which is supported by a temporally changing acoustic backscatter observed during the histotripsy process. In this paper, a fast-gated digital camera was used to image the hypothesized cavitating bubble cloud generated by histotripsy pulses. The bubble cloud was produced at a tissue-water interface and inside an optically transparent gelatin phantom which mimics bulk tissue. The imaging shows the following: (1) Initiation of a temporally changing acoustic backscatter was due to the formation of a bubble cloud; (2) The pressure threshold to generate a bubble cloud was lower at a tissue-fluid interface than inside bulk tissue; and (3) at higher pulse pressure, the bubble cloud lasted longer and grew larger. The results add further support to the hypothesis that the histotripsy process is due to a cavitating bubble cloud and may provide insight into the sharp boundaries of histotripsy lesions.

  14. Acoustic and Cavitation Fields of Shock Wave Therapy Devices

    NASA Astrophysics Data System (ADS)

    Chitnis, Parag V.; Cleveland, Robin O.

    2006-05-01

    Extracorporeal shock wave therapy (ESWT) is considered a viable treatment modality for orthopedic ailments. Despite increasing clinical use, the mechanisms by which ESWT devices generate a therapeutic effect are not yet understood. The mechanistic differences in various devices and their efficacies might be dependent on their acoustic and cavitation outputs. We report acoustic and cavitation measurements of a number of different shock wave therapy devices. Two devices were electrohydraulic: one had a large reflector (HMT Ossatron) and the other was a hand-held source (HMT Evotron); the other device was a pneumatically driven device (EMS Swiss DolorClast Vet). Acoustic measurements were made using a fiber-optic probe hydrophone and a PVDF hydrophone. A dual passive cavitation detection system was used to monitor cavitation activity. Qualitative differences between these devices were also highlighted using a high-speed camera. We found that the Ossatron generated focused shock waves with a peak positive pressure around 40 MPa. The Evotron produced peak positive pressure around 20 MPa, however, its acoustic output appeared to be independent of the power setting of the device. The peak positive pressure from the DolorClast was about 5 MPa without a clear shock front. The DolorClast did not generate a focused acoustic field. Shadowgraph images show that the wave propagating from the DolorClast is planar and not focused in the vicinity of the hand-piece. All three devices produced measurable cavitation with a characteristic time (cavitation inception to bubble collapse) that varied between 95 and 209 μs for the Ossatron, between 59 and 283 μs for the Evotron, and between 195 and 431 μs for the DolorClast. The high-speed camera images show that the cavitation activity for the DolorClast is primarily restricted to the contact surface of the hand-piece. These data indicate that the devices studied here vary in acoustic and cavitation output, which may imply that the

  15. Control of inertial acoustic cavitation in pulsed sonication using a real-time feedback loop system.

    PubMed

    Desjouy, Cyril; Poizat, Adrien; Gilles, Bruno; Inserra, Claude; Bera, Jean-Christophe

    2013-08-01

    Owing to the complex behavior of ultrasound-induced bubble clouds (nucleation, linear and nonlinear oscillations, collapse), acoustic cavitation remains a hardly controllable phenomenon, leading to poorly reproducible ultrasound-based therapies. A better control of the various aspects of cavitation phenomena for in vivo applications is a key requirement to improve emerging ultrasound therapies. Previous publications have reported on systems performing regulation of acoustic cavitation in continuous sonication when applied in vitro, but the main challenge today is to achieve real-time control of cavitation activity in pulsed sonication when used in vivo. The present work aims at developing a system to control acoustic cavitation in a pulsed wave condition using a real-time feedback loop. The experimental setup consists of a water bath in which is submerged a focused transducer (pulsed waves, frequency 550 kHz) used for sonication and a hydrophone used to listen to inertial cavitation. The designed regulation process allows the cavitation activity to be controlled through a 300 μs feedback loop. Without regulation, cavitation exhibits numerous bursts of intense activity and large variations of inertial cavitation level over time. In a regulated regime, the control of inertial cavitation activity within a pulse leads to consistent cavitation levels over time with an enhancement of the reproducibility.

  16. Bubble size distribution in acoustic droplet vaporization via dissolution using an ultrasound wide-beam method.

    PubMed

    Xu, Shanshan; Zong, Yujin; Li, Wusong; Zhang, Siyuan; Wan, Mingxi

    2014-05-01

    Performance and efficiency of numerous cavitation enhanced applications in a wide range of areas depend on the cavitation bubble size distribution. Therefore, cavitation bubble size estimation would be beneficial for biological and industrial applications that rely on cavitation. In this study, an acoustic method using a wide beam with low pressure is proposed to acquire the time intensity curve of the dissolution process for the cavitation bubble population and then determine the bubble size distribution. Dissolution of the cavitation bubbles in saline and in phase-shift nanodroplet emulsion diluted with undegassed or degassed saline was obtained to quantify the effects of pulse duration (PD) and acoustic power (AP) or peak negative pressure (PNP) of focused ultrasound on the size distribution of induced cavitation bubbles. It was found that an increase of PD will induce large bubbles while AP had only a little effect on the mean bubble size in saline. It was also recognized that longer PD and higher PNP increases the proportions of large and small bubbles, respectively, in suspensions of phase-shift nanodroplet emulsions. Moreover, degassing of the suspension tended to bring about smaller mean bubble size than the undegassed suspension. In addition, condensation of cavitation bubble produced in diluted suspension of phase-shift nanodroplet emulsion was involved in the calculation to discuss the effect of bubble condensation in the bubble size estimation in acoustic droplet vaporization. It was shown that calculation without considering the condensation might underestimate the mean bubble size and the calculation with considering the condensation might have more influence over the size distribution of small bubbles, but less effect on that of large bubbles. Without or with considering bubble condensation, the accessible minimum bubble radius was 0.4 or 1.7 μm and the step size was 0.3 μm. This acoustic technique provides an approach to estimate the size

  17. Processing of Microalgae: Acoustic Cavitation and Hydrothermal Conversion

    NASA Astrophysics Data System (ADS)

    Greenly, Justin Michael

    The production of energy dense fuels from renewable algal biomass feedstocks -- if sustainably developed at a sufficiently large scale -- may reduce the consumption of petroleum from fossil fuels and provide many environmental benefits. Achieving economic feasibility has several technical engineering challenges that arise from dilute concentration of growing algae in aqueous media, small cell sizes, and durable cell walls. For microalgae to be a sustainable source of biofuels and co-products, efficient fractionation and conversion of the cellular contents is necessary. Research was carried out to address two processing options for efficient microalgae biofuel production: 1. Ultrasonic cavitation for cell disruption and 2. Hydrothermal conversion of a model algal triglyceride. 1. Ultrasonic cell disruption, which relies on cavitating bubbles in the suspension to produce damaging shock waves, was investigated experimentally over a range of concentrations and species types. A few seconds of high intensity sonication at fixed frequency yielded significant cell disruption, even for the more durable cells. At longer exposure times, effectiveness was seen to decline and was attributed, using acoustic measurements, to ultrasonic power attenuation in the ensuing cloud of cavitating bubbles. Processing at higher cell concentrations slowed cell disintegration marginally, but increased the effectiveness of dissipating ultrasonic energy. A theoretical study effectively predicted optimal conditions for a variety of parameters that were inaccessible in this experimental investigation. In that study, single bubble collapse was modeled to identify operating conditions that would increase cavitation, and thus cell disruption. Simulations were conducted by varying frequency and pressure amplitude of the ultrasound wave, and initial bubble size. The simulation results indicated that low frequency, high sound wave amplitudes, and small initial bubble size generate the highest shock

  18. Supersonic microjets induced by hemispherical cavitation bubbles

    NASA Astrophysics Data System (ADS)

    Gonzalez-Avila, Roberto; Song, Chaolong; Ohl, Claus-Dieter

    2014-11-01

    In recent years methods to produce fast microjets have received significant attention due to their potential to be employed in needle-free injection devices that can provide mass inoculation. In this talk we present a novel technique capable of producing jets that can reach up to 400 m/s. The jets are produced by a device that consists only of two electrodes on a plastic substrate and a tapered hole of 13 ~ 20 μm between them. A short pulse of electric current is applied to the electrodes, then a spark bridges between the electrodes creating a cavitation bubble. Liquid is accelerated through the hole during the expansion and collapse of the bubble producing two separate jets. We found that as the exit velocity of the jet increases the jets become unstable. The second jet exiting the hole, usually faster than the first jet exits as a spray. The effect of viscosity was also studied with silicone oils up to 100 cSt. Finally, we also demonstrate that the jets can penetrate into soft material, thus they have the potential to be used in a needle-free drug-delivery application.

  19. Effect of dilute polymer additives on the acoustic cavitation threshold of water

    SciTech Connect

    Crum, L.A.; Brosey, J.E.

    1984-02-01

    Measurements are presented of the variation of the acoustic cavitation threshold of water with concentration of the polymer additives polyethylene oxide and guar gum. It was found that small amounts of these additives could significantly increase the cavitation threshold. A theoretical model, based upon nucleation of a gas bubble from a Harvey-type crevice in a mote or solid particle, is developed that gives good agreement with the measurements. The applicability of this approach to an explanation of cavitation index reduction in flow-generated or confined jet cavitation, when polymer additives are introduced, is discussed.

  20. Synchrotron quantification of ultrasound cavitation and bubble dynamics in Al-10Cu melts.

    PubMed

    Xu, W W; Tzanakis, I; Srirangam, P; Mirihanage, W U; Eskin, D G; Bodey, A J; Lee, P D

    2016-07-01

    Knowledge of the kinetics of gas bubble formation and evolution under cavitation conditions in molten alloys is important for the control casting defects such as porosity and dissolved hydrogen. Using in situ synchrotron X-ray radiography, we studied the dynamic behaviour of ultrasonic cavitation gas bubbles in a molten Al-10 wt%Cu alloy. The size distribution, average radius and growth rate of cavitation gas bubbles were quantified under an acoustic intensity of 800 W/cm(2) and a maximum acoustic pressure of 4.5 MPa (45 atm). Bubbles exhibited a log-normal size distribution with an average radius of 15.3 ± 0.5 μm. Under applied sonication conditions the growth rate of bubble radius, R(t), followed a power law with a form of R(t)=αt(β), and α=0.0021 &β=0.89. The observed tendencies were discussed in relation to bubble growth mechanisms of Al alloy melts. PMID:26964960

  1. Synchrotron quantification of ultrasound cavitation and bubble dynamics in Al-10Cu melts.

    PubMed

    Xu, W W; Tzanakis, I; Srirangam, P; Mirihanage, W U; Eskin, D G; Bodey, A J; Lee, P D

    2016-07-01

    Knowledge of the kinetics of gas bubble formation and evolution under cavitation conditions in molten alloys is important for the control casting defects such as porosity and dissolved hydrogen. Using in situ synchrotron X-ray radiography, we studied the dynamic behaviour of ultrasonic cavitation gas bubbles in a molten Al-10 wt%Cu alloy. The size distribution, average radius and growth rate of cavitation gas bubbles were quantified under an acoustic intensity of 800 W/cm(2) and a maximum acoustic pressure of 4.5 MPa (45 atm). Bubbles exhibited a log-normal size distribution with an average radius of 15.3 ± 0.5 μm. Under applied sonication conditions the growth rate of bubble radius, R(t), followed a power law with a form of R(t)=αt(β), and α=0.0021 &β=0.89. The observed tendencies were discussed in relation to bubble growth mechanisms of Al alloy melts.

  2. Sonoluminescence and multi-bubble cavitation phenomena for selected research and industrial applications

    NASA Astrophysics Data System (ADS)

    Greenwood, Larry; Olsen, Khris; Good, Morris; Bond, Leonard; Posakony, Gerald; Peters, Timothy; Baldwin, David; Wester, Dennis; Ahmed, Salahuddin

    2003-04-01

    Single bubble sonoluminescence (SBSL), multi-bubble sonoluminescence (MBSL), multi-bubble sonochemiluminescence (MBSCL) and other high power ultrasound cavitation and noncavitating ultrasound process stream interaction phenomena are known to produce a wide range of both physical and chemical effects that depend upon the system and operating conditions employed. Three interacting regimes are under investigation (a) high power and high frequency (including noncavitating systems), (b) single bubble resonance/sonoluminescence and (c) multi-bubble high power sonochemical processing. In all cases these involve various reactors, including possible schemes for continuous material feeding and processing for selected chemical, nonaqueous fluids and biological research and industrial applications. High power sonochemical and noncavitating ultrasound processing applications and a review of literature pertaining to the potential of high power processing, including fusion are discussed. Work includes the investigation of acoustic fields in reactors, characterization of sonoluminescence spectra, the investigation of system parameters to control maximum bubble temperature and pressure, and acoustic energy partition into light and acoustic emission/shock waves. Effects of various chemical systems on multi-bubble luminescence are being investigated and will be reported. Work to date has emphasized the evaluation of both single and multi-bubble sonoluminescence, spectral measurements, acoustic emission measurements and the observation of a continuous bubble feed phenomenon.

  3. Transient cavitation and acoustic emission produced by different laser lithotripters.

    PubMed

    Zhong, P; Tong, H L; Cocks, F H; Pearle, M S; Preminger, G M

    1998-08-01

    Transient cavitation and shockwave generation produced by pulsed-dye and holmium:YAG laser lithotripters were studied using high-speed photography and acoustic emission measurements. In addition, stone phantoms were used to compare the fragmentation efficiency of various laser and electrohydraulic lithotripters. The pulsed-dye laser, with a wavelength (504 nm) strongly absorbed by most stone materials but not by water, and a short pulse duration of approximately 1 microsec, induces plasma formation on the surface of the target calculi. Subsequently, the rapid expansion of the plasma forms a cavitation bubble, which expands spherically to a maximum size and then collapses violently, leading to strong shockwave generation and microjet impingement, which comprises the primary mechanism for stone fragmentation with short-pulse lasers. In contrast, the holmium laser, with a wavelength (2100 nm) most strongly absorbed by water as well as by all stone materials and a long pulse duration of 250 to 350 microsec, produces an elongated, pear-shaped cavitation bubble at the tip of the optical fiber that forms a vapor channel to conduct the ensuing laser energy to the target stone (Moss effect). The expansion and subsequent collapse of the elongated bubble is asymmetric, resulting in weak shockwave generation and microjet impingement. Thus, stone fragmentation in holmium laser lithotripsy is caused primarily by thermal ablation (drilling effect).

  4. Study of cavitation bubble dynamics during Ho:YAG laser lithotripsy by high-speed camera

    NASA Astrophysics Data System (ADS)

    Zhang, Jian J.; Xuan, Jason R.; Yu, Honggang; Devincentis, Dennis

    2016-02-01

    Although laser lithotripsy is now the preferred treatment option for urolithiasis, the mechanism of laser pulse induced calculus damage is still not fully understood. This is because the process of laser pulse induced calculus damage involves quite a few physical and chemical processes and their time-scales are very short (down to sub micro second level). For laser lithotripsy, the laser pulse induced impact by energy flow can be summarized as: Photon energy in the laser pulse --> photon absorption generated heat in the water liquid and vapor (super heat water or plasma effect) --> shock wave (Bow shock, acoustic wave) --> cavitation bubble dynamics (oscillation, and center of bubble movement , super heat water at collapse, sonoluminscence) --> calculus damage and motion (calculus heat up, spallation/melt of stone, breaking of mechanical/chemical bond, debris ejection, and retropulsion of remaining calculus body). Cavitation bubble dynamics is the center piece of the physical processes that links the whole energy flow chain from laser pulse to calculus damage. In this study, cavitation bubble dynamics was investigated by a high-speed camera and a needle hydrophone. A commercialized, pulsed Ho:YAG laser at 2.1 mu;m, StoneLightTM 30, with pulse energy from 0.5J up to 3.0 J, and pulse width from 150 mu;s up to 800 μs, was used as laser pulse source. The fiber used in the investigation is SureFlexTM fiber, Model S-LLF365, a 365 um core diameter fiber. A high-speed camera with frame rate up to 1 million fps was used in this study. The results revealed the cavitation bubble dynamics (oscillation and center of bubble movement) by laser pulse at different energy level and pulse width. More detailed investigation on bubble dynamics by different type of laser, the relationship between cavitation bubble dynamics and calculus damage (fragmentation/dusting) will be conducted as a future study.

  5. Inertial cavitation and associated acoustic emission produced during electrohydraulic shock wave lithotripsy.

    PubMed

    Zhong, P; Cioanta, I; Cocks, F H; Preminger, G M

    1997-05-01

    The inertial cavitation and associated acoustic emission generated during electrohydraulic shock wave lithotripsy were studied using high-speed photography and acoustic pressure measurements. The dynamics of cavitation bubble clusters, induced in vitro by an experimental laboratory lithotripter, were recorded using a high-speed rotating drum camera at 20,000 frames/s. The acoustic emission, generated by the rapid initial expansion and subsequent violent collapse of the cavitation bubbles, was measured simultaneously using a 1-MHz focused hydrophone, The expansion duration of the cavitation bubble cluster was found to correlate closely with the time delay between the first two groups of pressure spikes in the acoustic emission signal. This correlation provides an essential physical basis to assess the inertial cavitation produced by a clinical Dornier HM-3 shock wave lithotripter, both in water and in renal parenchyma of a swine model. In the clinical output voltage range (16-24 kV), the expansion duration of the primary cavitation bubble cluster generated by the HM-3 lithotripter in water increases from 158 to 254 microseconds, whereas the corresponding values in renal parenchyma are much smaller and remain almost unchanged (from 71 to 72 microseconds). In contrast, subsequent oscillation of the bubble following its primary collapse is significantly prolonged (from 158-235 microseconds in water to 1364-1373 microseconds in renal parenchyma). These distinctive differences between lithotripsy-induced inertial cavitation in vitro and that in vivo are presumably due to the constraining effect of renal tissue on bubble expansion. PMID:9165740

  6. Transient oscillation of cavitation bubbles near stone surface during electrohydraulic lithotripsy.

    PubMed

    Zhong, P; Tong, H L; Cocks, F H; Preminger, G M

    1997-02-01

    Using high-speed photography and acoustic emission measurements, we studied the dynamics of a transient cavitation bubble near a stone surface and the concomitant shockwaves generated during electrohydraulic lithotripsy (EHL). At each spark discharge, a vapor plasma and subsequently a cavitation bubble oscillating around the tip of an EHL probe are produced. Simultaneously, three distinctive shockwave pulses are generated. The first shockwave is produced by the rapid expansion of the vapor plasma, while the second and third waves are produced by rebounds of the cavitation bubble. Depending on the proximity of the probe to the stone surface, the collapse of the cavitation bubble may be symmetric, resulting in a strong shockwave emission; or asymmetric, leading to the formation of a liquid jet. For the Nortech AUTOLITH lithotripter with a 1.9F probe that was used in this study, maximum shockwave emission is produced when the probe is about 1 mm from the stone surface, whereas the maximum jet velocity is produced when the probe tip is at distance equivalent to the maximum bubble radius of about 3 mm. These findings are consistent with clinical experience, which suggests that for optimal treatment results, the EHL probe should be placed close to the stone surface.

  7. Localized removal of layers of metal, polymer, or biomaterial by ultrasound cavitation bubbles.

    PubMed

    Fernandez Rivas, David; Verhaagen, Bram; Seddon, James R T; Zijlstra, Aaldert G; Jiang, Lei-Meng; van der Sluis, Luc W M; Versluis, Michel; Lohse, Detlef; Gardeniers, Han J G E

    2012-09-01

    We present an ultrasonic device with the ability to locally remove deposited layers from a glass slide in a controlled and rapid manner. The cleaning takes place as the result of cavitating bubbles near the deposited layers and not due to acoustic streaming. The bubbles are ejected from air-filled cavities micromachined in a silicon surface, which, when vibrated ultrasonically at a frequency of 200 kHz, generate a stream of bubbles that travel to the layer deposited on an opposing glass slide. Depending on the pressure amplitude, the bubble clouds ejected from the micropits attain different shapes as a result of complex bubble interaction forces, leading to distinct shapes of the cleaned areas. We have determined the removal rates for several inorganic and organic materials and obtained an improved efficiency in cleaning when compared to conventional cleaning equipment. We also provide values of the force the bubbles are able to exert on an atomic force microscope tip.

  8. Ultrasonic emissions reveal individual cavitation bubbles in water-stressed wood.

    PubMed

    Ponomarenko, A; Vincent, O; Pietriga, A; Cochard, H; Badel, É; Marmottant, P

    2014-10-01

    Under drought conditions, the xylem of trees that conducts ascending sap produces ultrasonic emissions whose exact origin is not clear. We introduce a new method to record simultaneously both acoustic events and optical observation of the xylem conduits within slices of wood that were embedded in a transparent material setting a hydric stress. In this article, we resolved the rapid development of all cavitation bubbles and demonstrated that each ultrasound emission was linked to the nucleation of one single bubble, whose acoustic energy is an increasing function of the size of the conduit where nucleation occurred and also of the hydric stress. We modelled these observations by the fact that water columns in conduits store elastic energy and release it into acoustic waves when they are broken by cavitation bubbles. Water columns are thus elastic, and not rigid, 'wires of water' set under tension by hydric stresses. Cavitation bubbles are at the origin of an embolism, whose development was followed in our experiments. Such an embolism of sap circulation can result in a fatal condition for living trees. These findings provide new insights for the non-destructive monitoring of embolisms within trees, and suggest a new approach to study porous media under hydric stress.

  9. Ultrasonic emissions reveal individual cavitation bubbles in water-stressed wood

    PubMed Central

    Ponomarenko, A.; Vincent, O.; Pietriga, A.; Cochard, H.; Badel, É.; Marmottant, P.

    2014-01-01

    Under drought conditions, the xylem of trees that conducts ascending sap produces ultrasonic emissions whose exact origin is not clear. We introduce a new method to record simultaneously both acoustic events and optical observation of the xylem conduits within slices of wood that were embedded in a transparent material setting a hydric stress. In this article, we resolved the rapid development of all cavitation bubbles and demonstrated that each ultrasound emission was linked to the nucleation of one single bubble, whose acoustic energy is an increasing function of the size of the conduit where nucleation occurred and also of the hydric stress. We modelled these observations by the fact that water columns in conduits store elastic energy and release it into acoustic waves when they are broken by cavitation bubbles. Water columns are thus elastic, and not rigid, ‘wires of water’ set under tension by hydric stresses. Cavitation bubbles are at the origin of an embolism, whose development was followed in our experiments. Such an embolism of sap circulation can result in a fatal condition for living trees. These findings provide new insights for the non-destructive monitoring of embolisms within trees, and suggest a new approach to study porous media under hydric stress. PMID:25056212

  10. Cavitation and bubble dynamics: the Kelvin impulse and its applications.

    PubMed

    Blake, John R; Leppinen, David M; Wang, Qianxi

    2015-10-01

    Cavitation and bubble dynamics have a wide range of practical applications in a range of disciplines, including hydraulic, mechanical and naval engineering, oil exploration, clinical medicine and sonochemistry. However, this paper focuses on how a fundamental concept, the Kelvin impulse, can provide practical insights into engineering and industrial design problems. The pathway is provided through physical insight, idealized experiments and enhancing the accuracy and interpretation of the computation. In 1966, Benjamin and Ellis made a number of important statements relating to the use of the Kelvin impulse in cavitation and bubble dynamics, one of these being 'One should always reason in terms of the Kelvin impulse, not in terms of the fluid momentum…'. We revisit part of this paper, developing the Kelvin impulse from first principles, using it, not only as a check on advanced computations (for which it was first used!), but also to provide greater physical insights into cavitation bubble dynamics near boundaries (rigid, potential free surface, two-fluid interface, flexible surface and axisymmetric stagnation point flow) and to provide predictions on different types of bubble collapse behaviour, later compared against experiments. The paper concludes with two recent studies involving (i) the direction of the jet formation in a cavitation bubble close to a rigid boundary in the presence of high-intensity ultrasound propagated parallel to the surface and (ii) the study of a 'paradigm bubble model' for the collapse of a translating spherical bubble, sometimes leading to a constant velocity high-speed jet, known as the Longuet-Higgins jet.

  11. Development of an Acoustic Localization Method for Cavitation Experiments in Reverberant Environments

    NASA Astrophysics Data System (ADS)

    Ranjeva, Minna; Thompson, Lee; Perlitz, Daniel; Bonness, William; Capone, Dean; Elbing, Brian

    2011-11-01

    Cavitation is a major concern for the US Navy since it can cause ship damage and produce unwanted noise. The ability to precisely locate cavitation onset in laboratory scale experiments is essential for proper design that will minimize this undesired phenomenon. Measuring the cavitation onset is more accurately determined acoustically than visually. However, if other parts of the model begin to cavitate prior to the component of interest the acoustic data is contaminated with spurious noise. Consequently, cavitation onset is widely determined by optically locating the event of interest. The current research effort aims at developing an acoustic localization scheme for reverberant environments such as water tunnels. Currently cavitation bubbles are being induced in a static water tank with a laser, allowing the localization techniques to be refined with the bubble at a known location. The source is located with the use of acoustic data collected with hydrophones and analyzed using signal processing techniques. To verify the accuracy of the acoustic scheme, the events are simultaneously monitored visually with the use of a high speed camera. Once refined testing will be conducted in a water tunnel. This research was sponsored by the Naval Engineering Education Center (NEEC).

  12. A reduced-order, single-bubble cavitation model with applications to therapeutic ultrasound

    PubMed Central

    Kreider, Wayne; Crum, Lawrence A.; Bailey, Michael R.; Sapozhnikov, Oleg A.

    2011-01-01

    Cavitation often occurs in therapeutic applications of medical ultrasound such as shock-wave lithotripsy (SWL) and high-intensity focused ultrasound (HIFU). Because cavitation bubbles can affect an intended treatment, it is important to understand the dynamics of bubbles in this context. The relevant context includes very high acoustic pressures and frequencies as well as elevated temperatures. Relative to much of the prior research on cavitation and bubble dynamics, such conditions are unique. To address the relevant physics, a reduced-order model of a single, spherical bubble is proposed that incorporates phase change at the liquid-gas interface as well as heat and mass transport in both phases. Based on the energy lost during the inertial collapse and rebound of a millimeter-sized bubble, experimental observations were used to tune and test model predictions. In addition, benchmarks from the published literature were used to assess various aspects of model performance. Benchmark comparisons demonstrate that the model captures the basic physics of phase change and diffusive transport, while it is quantitatively sensitive to specific model assumptions and implementation details. Given its performance and numerical stability, the model can be used to explore bubble behaviors across a broad parameter space relevant to therapeutic ultrasound. PMID:22088026

  13. Activating Molecules, Ions, and Solid Particles with Acoustic Cavitation

    PubMed Central

    Pflieger, Rachel; Chave, Tony; Virot, Matthieu; Nikitenko, Sergey I.

    2014-01-01

    The chemical and physical effects of ultrasound arise not from a direct interaction of molecules with sound waves, but rather from the acoustic cavitation: the nucleation, growth, and implosive collapse of microbubbles in liquids submitted to power ultrasound. The violent implosion of bubbles leads to the formation of chemically reactive species and to the emission of light, named sonoluminescence. In this manuscript, we describe the techniques allowing study of extreme intrabubble conditions and chemical reactivity of acoustic cavitation in solutions. The analysis of sonoluminescence spectra of water sparged with noble gases provides evidence for nonequilibrium plasma formation. The photons and the "hot" particles generated by cavitation bubbles enable to excite the non-volatile species in solutions increasing their chemical reactivity. For example the mechanism of ultrabright sonoluminescence of uranyl ions in acidic solutions varies with uranium concentration: sonophotoluminescence dominates in diluted solutions, and collisional excitation contributes at higher uranium concentration. Secondary sonochemical products may arise from chemically active species that are formed inside the bubble, but then diffuse into the liquid phase and react with solution precursors to form a variety of products. For instance, the sonochemical reduction of Pt(IV) in pure water provides an innovative synthetic route for monodispersed nanoparticles of metallic platinum without any templates or capping agents. Many studies reveal the advantages of ultrasound to activate the divided solids. In general, the mechanical effects of ultrasound strongly contribute in heterogeneous systems in addition to chemical effects. In particular, the sonolysis of PuO2 powder in pure water yields stable colloids of plutonium due to both effects. PMID:24747272

  14. Acoustical scattering cross section of gas bubbles under dual-frequency acoustic excitation.

    PubMed

    Zhang, Yuning; Li, Shengcai

    2015-09-01

    The acoustical scattering cross section is a paramount parameter determining the scattering ability of cavitation bubbles when they are excited by the incident acoustic waves. This parameter is strongly related with many important applications of acoustic cavitation including facilitating the reaction of chemical process, boosting bubble sonoluminescence, and performing non-invasive therapy and drug delivery. In present paper, both the analytical and numerical solutions of acoustical scattering cross section of gas bubbles under dual-frequency excitation are obtained. The validity of the analytical solution is shown with demonstrating examples. The nonlinear characteristics (e.g., harmonics, subharmonics and ultraharmonics) of the scattering cross section curve under dual-frequency approach are investigated. Compared with single-frequency approach, the dual-frequency approach displays more resonances termed as "combination resonances" and could promote the acoustical scattering cross section significantly within a much broader range of bubble sizes due to the generation of more resonances. The influence of several paramount parameters (e.g., acoustic pressure amplitude, power allocations between two acoustic components, and the ratio of the frequencies) in the dual-frequency system on the predictions of scattering cross section has been discussed.

  15. Micro Bubble Trapping By Acoustic Energy

    NASA Astrophysics Data System (ADS)

    Yoshiki, Yamakoshi

    2005-03-01

    Micro bubble trapping by acoustic energy is a promising technology for a future drug or gene delivery system, because the method can control the bubble dynamics using an applied ultrasonic wave. In this paper, acoustic radiation forces which are applied to the micro bubbles are reviewed as well as their applications for micro bubble manipulation. One of the problems in micro bubble trapping by acoustic energy is that the force applied to the micro bubbles is insufficient for some bubbles. This is severe problem when the bubble has a relatively hard shell. In order to increase the trapping force on the micro bubbles, a novel method is proposed. This method uses seed bubbles in order to manipulate target bubbles.

  16. Impact of acoustic cavitation on food emulsions.

    PubMed

    Krasulya, Olga; Bogush, Vladimir; Trishina, Victoria; Potoroko, Irina; Khmelev, Sergey; Sivashanmugam, Palani; Anandan, Sambandam

    2016-05-01

    The work explores the experimental and theoretical aspects of emulsification capability of ultrasound to deliver stable emulsions of sunflower oil in water and meat sausages. In order to determine optimal parameters for direct ultrasonic emulsification of food emulsions, a model was developed based on the stability of emulsion droplets in acoustic cavitation field. The study is further extended to investigate the ultrasound induced changes to the inherent properties of raw materials under the experimental conditions of sono-emulsification.

  17. Impact of acoustic cavitation on food emulsions.

    PubMed

    Krasulya, Olga; Bogush, Vladimir; Trishina, Victoria; Potoroko, Irina; Khmelev, Sergey; Sivashanmugam, Palani; Anandan, Sambandam

    2016-05-01

    The work explores the experimental and theoretical aspects of emulsification capability of ultrasound to deliver stable emulsions of sunflower oil in water and meat sausages. In order to determine optimal parameters for direct ultrasonic emulsification of food emulsions, a model was developed based on the stability of emulsion droplets in acoustic cavitation field. The study is further extended to investigate the ultrasound induced changes to the inherent properties of raw materials under the experimental conditions of sono-emulsification. PMID:26603612

  18. The recreation of a unique shrimp's mechanically induced cavitation bubble

    NASA Astrophysics Data System (ADS)

    Miller, Ryan; Dougherty, Christopher; Eliasson, Veronica; Khanolkar, Gauri

    2014-11-01

    The Alpheus heterochaelis, appropriately nicknamed the ``pistol shrimp,'' possesses an oversized claw that creates a cavitation bubble upon rapid closure. The implosion of this bubble results in a shock wave that can stun or even kill the shrimp's prey (Versluis et al., 2000). Additionally, the implosion is so violent that sonoluminescence may occur. This light implies extreme temperatures, which have been recorded to reach as high as 10,000 K (Roach, 2001). By developing an analogous mechanism to the oversized claw, the goal of this experiment is to verify that cavitation can be produced similar to that of the pistol shrimp in nature as well as to analyze the resulting shock wave and sonoluminescence. High-speed schlieren imaging was used to observe the shock dynamics. Furthermore, results on cavitation collapse and light emission will be presented. USC Provost Undergraduate Research Fellowship/Rose Hills Undergraduate Research Fellowship.

  19. Energy partition at the collapse of spherical cavitation bubbles.

    PubMed

    Tinguely, M; Obreschkow, D; Kobel, P; Dorsaz, N; de Bosset, A; Farhat, M

    2012-10-01

    Spherically collapsing cavitation bubbles produce a shock wave followed by a rebound bubble. Here we present a systematic investigation of the energy partition between the rebound and the shock. Highly spherical cavitation bubbles are produced in microgravity, which suppresses the buoyant pressure gradient that otherwise deteriorates the sphericity of the bubbles. We measure the radius of the rebound bubble and estimate the shock energy as a function of the initial bubble radius (2-5.6mm) and the liquid pressure (10-80kPa). Those measurements uncover a systematic pressure dependence of the energy partition between rebound and shock. We demonstrate that these observations agree with a physical model relying on a first-order approximation of the liquid compressibility and an adiabatic treatment of the noncondensable gas inside the bubble. Using this model we find that the energy partition between rebound and shock is dictated by a single nondimensional parameter ξ=Δpγ6/[p(g0)1/γ(ρc2)1-1/γ], where Δp=p∞ - pv is the driving pressure, p∞ is the static pressure in the liquid, pv is the vapor pressure, pg0 is the pressure of the noncondensable gas at the maximal bubble radius, γ is the adiabatic index of the noncondensable gas, ρ is the liquid density, and c is the speed of sound in the liquid.

  20. Energy partition at the collapse of spherical cavitation bubbles

    NASA Astrophysics Data System (ADS)

    Tinguely, M.; Obreschkow, D.; Kobel, P.; Dorsaz, N.; de Bosset, A.; Farhat, M.

    2012-10-01

    Spherically collapsing cavitation bubbles produce a shock wave followed by a rebound bubble. Here we present a systematic investigation of the energy partition between the rebound and the shock. Highly spherical cavitation bubbles are produced in microgravity, which suppresses the buoyant pressure gradient that otherwise deteriorates the sphericity of the bubbles. We measure the radius of the rebound bubble and estimate the shock energy as a function of the initial bubble radius (2-5.6mm) and the liquid pressure (10-80kPa). Those measurements uncover a systematic pressure dependence of the energy partition between rebound and shock. We demonstrate that these observations agree with a physical model relying on a first-order approximation of the liquid compressibility and an adiabatic treatment of the noncondensable gas inside the bubble. Using this model we find that the energy partition between rebound and shock is dictated by a single nondimensional parameter ξ=Δpγ6/[pg01/γ(ρc2)1-1/γ], where Δp=p∞-pv is the driving pressure, p∞ is the static pressure in the liquid, pv is the vapor pressure, pg0 is the pressure of the noncondensable gas at the maximal bubble radius, γ is the adiabatic index of the noncondensable gas, ρ is the liquid density, and c is the speed of sound in the liquid.

  1. Cavitation and bubble dynamics: the Kelvin impulse and its applications

    PubMed Central

    Blake, John R.; Leppinen, David M.; Wang, Qianxi

    2015-01-01

    Cavitation and bubble dynamics have a wide range of practical applications in a range of disciplines, including hydraulic, mechanical and naval engineering, oil exploration, clinical medicine and sonochemistry. However, this paper focuses on how a fundamental concept, the Kelvin impulse, can provide practical insights into engineering and industrial design problems. The pathway is provided through physical insight, idealized experiments and enhancing the accuracy and interpretation of the computation. In 1966, Benjamin and Ellis made a number of important statements relating to the use of the Kelvin impulse in cavitation and bubble dynamics, one of these being ‘One should always reason in terms of the Kelvin impulse, not in terms of the fluid momentum…’. We revisit part of this paper, developing the Kelvin impulse from first principles, using it, not only as a check on advanced computations (for which it was first used!), but also to provide greater physical insights into cavitation bubble dynamics near boundaries (rigid, potential free surface, two-fluid interface, flexible surface and axisymmetric stagnation point flow) and to provide predictions on different types of bubble collapse behaviour, later compared against experiments. The paper concludes with two recent studies involving (i) the direction of the jet formation in a cavitation bubble close to a rigid boundary in the presence of high-intensity ultrasound propagated parallel to the surface and (ii) the study of a ‘paradigm bubble model’ for the collapse of a translating spherical bubble, sometimes leading to a constant velocity high-speed jet, known as the Longuet-Higgins jet. PMID:26442141

  2. An Acoustofluidic Micromixer via Bubble Inception and Cavitation from Microchannel Sidewalls

    PubMed Central

    2015-01-01

    During the deep reactive ion etching process, the sidewalls of a silicon mold feature rough wavy structures, which can be transferred onto a polydimethylsiloxane (PDMS) microchannel through the soft lithography technique. In this article, we utilized the wavy structures of PDMS microchannel sidewalls to initiate and cavitate bubbles in the presence of acoustic waves. Through bubble cavitation, this acoustofluidic approach demonstrates fast, effective mixing in microfluidics. We characterized its performance by using viscous fluids such as poly(ethylene glycol) (PEG). When two PEG solutions with a resultant viscosity 54.9 times higher than that of water were used, the mixing efficiency was found to be 0.92, indicating excellent, homogeneous mixing. The acoustofluidic micromixer presented here has the advantages of simple fabrication, easy integration, and capability to mix high-viscosity fluids (Reynolds number: ∼0.01) in less than 100 ms. PMID:24754496

  3. Single bubble perturbation in cavitation proximity of solid glass: hot spot versus distance.

    PubMed

    Radziuk, Darya; Möhwald, Helmuth; Suslick, Kenneth

    2014-02-28

    A systematic study of the energy loss of a cavitation bubble in a close proximity of a glass surface is introduced for the first time in a low acoustic field (1.2-2.4 bar). Single bubble sonoluminescence (SBSL) is used as a tool to predict the temperature and pressure decrease of bubble (μm) versus surface distance. A glass as a model system is used to imitate the boundary conditions relevant for nano- or micromaterials. SBSL preequilibrated with 5% argon is perturbed by a glass rod with the tip (Z-perturbation) and with the long axis (X-perturbation) at a defined distance. From 2 mm to 500 μm argon-SBSL lines monotonically narrow and the effective emission temperature decreases from 9000 K to 6800 K comparable to multiple bubbles. The electron density decreases by two orders of magnitude in Z-perturbation and is by a factor of two higher in X-perturbation than the unperturbed cavitating bubble. The perturbed single bubble sonoluminescence pressure decreases from 2700 atm to 1200 atm at 2.4 bar. In water new non-SBSL SiO molecular emission lines are observed and OH emission disappears.

  4. Cavitation in confined water: ultra-fast bubble dynamics

    NASA Astrophysics Data System (ADS)

    Vincent, Olivier; Marmottant, Philippe

    2012-02-01

    In the hydraulic vessels of trees, water can be found at negative pressure. This metastable state, corresponding to mechanical tension, is achieved by evaporation through a porous medium. It can be relaxed by cavitation, i.e. the sudden nucleation of vapor bubbles. Harmful for the tree due to the subsequent emboli of sap vessels, cavitation is on the contrary used by ferns to eject spores very swiftly. We will focus here on the dynamics of the cavitation bubble, which is of primary importance to explain the previously cited natural phenomena. We use the recently developed method of artificial tress, using transparent hydrogels as the porous medium. Our experiments, on water confined in micrometric hydrogel cavities, show an extremely fast dynamics: bubbles are nucleated at the microsecond timescale. For cavities larger than 100 microns, the bubble ``rings'' with damped oscillations at MHz frequencies, whereas for smaller cavities the oscillations become overdamped. This rich dynamics can be accounted for by a model we developed, leading to a modified Rayleigh-Plesset equation. Interestingly, this model predicts the impossibility to nucleate bubbles above a critical confinement that depends on liquid negative pressure and corresponds to approximately 100 nm for 20 MPa tensions.

  5. Effects of tissue stiffness, ultrasound frequency, and pressure on histotripsy-induced cavitation bubble behavior

    NASA Astrophysics Data System (ADS)

    Vlaisavljevich, Eli; Lin, Kuang-Wei; Warnez, Matthew T.; Singh, Rahul; Mancia, Lauren; Putnam, Andrew J.; Johnsen, Eric; Cain, Charles; Xu, Zhen

    2015-03-01

    Histotripsy is an ultrasound ablation method that controls cavitation to fractionate soft tissue. In order to effectively fractionate tissue, histotripsy requires cavitation bubbles to rapidly expand from nanometer-sized initial nuclei into bubbles often larger than 50 µm. Using a negative pressure high enough to initiate a bubble cloud and expand bubbles to a sufficient size, histotripsy has been shown capable of completely fractionating soft tissue into acelluar debris resulting in effective tissue removal. Previous work has shown that the histotripsy process is affected by tissue mechanical properties with stiffer tissues showing increased resistance to histotripsy fractionation, which we hypothesize to be caused by impeded bubble expansion in stiffer tissues. In this study, the hypothesis that increases in tissue stiffness cause a reduction in bubble expansion was investigated both theoretically and experimentally. High speed optical imaging was used to capture a series of time delayed images of bubbles produced inside mechanically tunable agarose tissue phantoms using histotripsy pulses produced by 345 kHz, 500 kHz, 1.5 MHz, and 3 MHz histotripsy transducers. The results demonstrated a significant decrease in maximum bubble radius (Rmax) and collapse time (tc) with both increasing Young’s modulus and increasing frequency. Furthermore, results showed that Rmax was not increased by raising the pressure above the intrinsic threshold. Finally, this work demonstrated the potential of using a dual-frequency strategy to modulate the expansion of histotripsy bubbles. Overall, the results of this study improve our understanding of how tissue stiffness and ultrasound parameters affect histotripsy-induced bubble behavior and provide a rational basis to tailor acoustic parameters for treatment of the specific tissues of interest.

  6. Effects of Tissue Stiffness, Ultrasound Frequency, and Pressure on Histotripsy-induced Cavitation Bubble Behavior

    PubMed Central

    Vlaisavljevich, Eli; Lin, Kuang-Wei; Warnez, Matthew; Singh, Rahul; Mancia, Lauren; Putnam, Andrew J.; Johnsen, Eric; Cain, Charles; Xu, Zhen

    2015-01-01

    Histotripsy is an ultrasound ablation method that controls cavitation to fractionate soft tissue. In order to effectively fractionate tissue, histotripsy requires cavitation bubbles to rapidly expand from nanometer-sized initial nuclei into bubbles often larger than 50 microns. Using a negative pressure high enough to initiate a bubble cloud and expand bubbles to a sufficient size, histotripsy has been shown capable of completely fractionating soft tissue into acelluar debris resulting in effective tissue removal. Previous work has shown that the histotripsy process is affected by tissue mechanical properties with stiffer tissues showing increased resistance to histotripsy fractionation, which we hypothesize to be caused by impeded bubble expansion in stiffer tissues. In this study, the hypothesis that increases in tissue stiffness causes a reduction in bubble expansion was investigated both theoretically and experimentally. High speed optical imaging was used to capture a series of time delayed images of bubbles produced inside mechanically tunable agarose tissue phantoms using histotripsy pulses produced by 345 kHz, 500 kHz, 1.5 MHz, and 3 MHz histotripsy transducers. The results demonstrated a significant decrease in maximum bubble radius (Rmax) and collapse time (tc) with both increasing Young’s modulus and increasing frequency. Furthermore, results showed that Rmax was not increased by raising the pressure above the intrinsic threshold. Finally, this work demonstrated the potential of using a dual-frequency strategy to modulate the expansion of histotripsy bubbles. Overall, the results of this study improve our understanding of how tissue stiffness and ultrasound parameters affect histotripsy-induced bubble behavior and provide a rational basis to tailor acoustic parameters for treatment of the specific tissues of interest. PMID:25715732

  7. Effect of supercritical water shell on cavitation bubble dynamics

    NASA Astrophysics Data System (ADS)

    Shao, Wei-Hang; Chen, Wei-Zhong

    2015-05-01

    Based on reported experimental data, a new model for single cavitation bubble dynamics is proposed considering a supercritical water (SCW) shell surrounding the bubble. Theoretical investigations show that the SCW shell apparently slows down the oscillation of the bubble and cools the gas temperature inside the collapsing bubble. Furthermore, the model is simplified to a Rayleigh-Plesset-like equation for a thin SCW shell. The dependence of the bubble dynamics on the thickness and density of the SCW shell is studied. The results show the bubble dynamics depends on the thickness but is insensitive to the density of the SCW shell. The thicker the SCW shell is, the smaller are the wall velocity and the gas temperature in the bubble. In the authors’ opinion, the SCW shell works as a buffering agent. In collapsing, it is compressed to absorb a good deal of the work transformed into the bubble internal energy during bubble collapse so that it weakens the bubble oscillations. Project supported by the National Natural Science Foundation of China (Grant Nos. 11174145 and 11334005).

  8. Modeling of surface cleaning by cavitation bubble dynamics and collapse.

    PubMed

    Chahine, Georges L; Kapahi, Anil; Choi, Jin-Keun; Hsiao, Chao-Tsung

    2016-03-01

    Surface cleaning using cavitation bubble dynamics is investigated numerically through modeling of bubble dynamics, dirt particle motion, and fluid material interaction. Three fluid dynamics models; a potential flow model, a viscous model, and a compressible model, are used to describe the flow field generated by the bubble all showing the strong effects bubble explosive growth and collapse have on a dirt particle and on a layer of material to remove. Bubble deformation and reentrant jet formation are seen to be responsible for generating concentrated pressures, shear, and lift forces on the dirt particle and high impulsive loads on a layer of material to remove. Bubble explosive growth is also an important mechanism for removal of dirt particles, since strong suction forces in addition to shear are generated around the explosively growing bubble and can exert strong forces lifting the particles from the surface to clean and sucking them toward the bubble. To model material failure and removal, a finite element structure code is used and enables simulation of full fluid-structure interaction and investigation of the effects of various parameters. High impulsive pressures are generated during bubble collapse due to the impact of the bubble reentrant jet on the material surface and the subsequent collapse of the resulting toroidal bubble. Pits and material removal develop on the material surface when the impulsive pressure is large enough to result in high equivalent stresses exceeding the material yield stress or its ultimate strain. Cleaning depends on parameters such as the relative size between the bubble at its maximum volume and the particle size, the bubble standoff distance from the particle and from the material wall, and the excitation pressure field driving the bubble dynamics. These effects are discussed in this contribution.

  9. Cavitation bubble dynamics during thulium fiber laser lithotripsy

    NASA Astrophysics Data System (ADS)

    Hardy, Luke A.; Kennedy, Joshua D.; Wilson, Christopher R.; Irby, Pierce B.; Fried, Nathaniel M.

    2016-02-01

    The Thulium fiber laser (TFL) is being explored for lithotripsy. TFL parameters differ from standard Holmium:YAG laser in several ways, including smaller fiber delivery, more strongly absorbed wavelength, low pulse energy/high pulse rate operation, and more uniform temporal pulse structure. High speed imaging of cavitation bubbles was performed at 105,000 fps and 10 μm spatial resolution to determine influence of these laser parameters on bubble formation. TFL was operated at 1908 nm with pulse energies of 5-75 mJ, and pulse durations of 200-1000 μs, delivered through 100-μm-core fiber. Cavitation bubble dynamics using Holmium laser at 2100 nm with pulse energies of 200-1000 mJ and pulse duration of 350 μs was studied, for comparison. A single, 500 μs TFL pulse produced a bubble stream extending 1090 +/- 110 μm from fiber tip, and maximum bubble diameters averaged 590 +/- 20 μm (n=4). These observations are consistent with previous studies which reported TFL ablation stallout at working distances < 1.0 mm. TFL bubble dimensions were five times smaller than for Holmium laser due to lower pulse energy, higher water absorption coefficient, and smaller fiber diameter used.

  10. Shock wave emission during the collapse of cavitation bubbles

    NASA Astrophysics Data System (ADS)

    Garen, W.; Hegedűs, F.; Kai, Y.; Koch, S.; Meyerer, B.; Neu, W.; Teubner, U.

    2016-07-01

    Shock wave emission induced by intense laser pulses is investigated experimentally. The present work focuses on the conditions of shock wave emission in glycerine and distilled water during the first bubble collapse. Experimental investigations are carried out in liquids as a function of temperature and viscosity. Comparison is made with the theoretical work of Poritsky (Proc 1st US Natl Congress Appl Mech 813-821, 1952) and Brennen (Cavitation and bubble dynamics, Oxford University Press 1995). To the best knowledge of the authors, this is the first experimental verification of those theories.

  11. Modeling of cavitation-bubble compression in benzene

    NASA Astrophysics Data System (ADS)

    Dnestrovskii, A. Yu.; Voropaev, S. A.; Zabrodina, E. A.

    2016-08-01

    In this study a two-dimensional model for calculating cavitation-bubble compression in benzene using a wide range of equations of state for ultrahigh pressures and temperatures is constructed. The calculations are carried out on the supercomputer of the Keldysh IAM. With the help of this model, the possibility of hits in the diamond-formation mode depending on the parameters of the external pressure and the initial bubble radius are analyzed. The dependence of the duration of the presence in the diamond-formation mode on these parameters is investigated.

  12. Shock wave emission from laser-induced cavitation bubbles in polymer solutions.

    PubMed

    Brujan, Emil-Alexandru

    2008-09-01

    The role of extensional viscosity on the acoustic emission from laser-induced cavitation bubbles in polymer solutions and near a rigid boundary is investigated by acoustic measurements. The polymer solutions consist of a 0.5% polyacrylamide (PAM) aqueous solution with a strong elastic component and a 0.5% carboxymethylcellulose (CMC) aqueous solution with a weak elastic component. A reduction of the maximum amplitude of the shock wave pressure and a prolongation of the oscillation period of the bubble were found in the elastic PAM solution. It might be caused by an increased resistance to extensional flow which is conferred upon the liquid by the polymer additive. In both polymer solutions, however, the shock pressure decays proportionally to r(-1) with increasing distance r from the emission centre.

  13. Cavitation bubble behavior inside a liquid jet

    NASA Astrophysics Data System (ADS)

    Robert, Etienne; Lettry, Jacques; Farhat, Mohamed; Monkewitz, Peter A.; Avellan, François

    2007-06-01

    The growth and collapse of laser-induced vapor cavities inside axisymmetric free-falling liquid water jets have been studied. Bubbles of different size are generated at various distances from the jet axis and the effects on the jet interface are recorded by means of ultrafast cinematography. The configuration is characterized by two dimensionless parameters: the bubble to jet diameter ratio δ and the eccentricity coefficient ɛ defined as the radius of bubble generation divided by the jet radius. For high δ and ɛ, microjets and droplets are ejected from the liquid jet at speeds exceeding 100m/s. The observed jet fragmentation shows similarities with experiments conducted on a liquid mercury jet hit by a pulsed proton beam, a candidate configuration for future accelerator based facilities.

  14. Reduction of Bubble Cavitation by Modifying the Diffraction Wave from a Lithotripter Aperture

    PubMed Central

    2012-01-01

    Abstract Purpose A new method was devised to suppress the bubble cavitation in the lithotripter focal zone to reduce the propensity of shockwave-induced renal injury. Materials and Methods An edge extender was designed and fabricated to fit on the outside of the ellipsoidal reflector of an electrohydraulic lithotripter to disturb the generation of diffraction wave at the aperture, but with little effect on the acoustic field inside the reflector. Results Although the peak negative pressures at the lithotripter focus using the edge extender at 20 kV were similar to that of the original configuration (-11.1±0.9 vs −10.6±0.7 MPa), the duration of the tensile wave was shortened significantly (3.2±0.54 vs 5.83±0.56 μs, P<0.01). There is no difference, however, in both the amplitude and duration of the compressive shockwaves between these two configurations as well as the −6 dB beam width in the focal plane. The significant suppression effect of bubble cavitation was confirmed by the measured bubble collapse time using passive cavitation detection. At the lithotripter focus, while only about 30 shocks were needed to rupture a blood vessel phantom using the original HM-3 reflector at 20 kV, no damage could be produced after 300 shocks using the edge extender. Meanwhile, the original HM-3 lithotripter at 20 kV can achieve a stone comminution efficiency of 50.4±2.0% on plaster-of-Paris stone phantom after 200 shocks, which is comparable to that of using the edge extender (46.8±4.1%, P=0.005). Conclusions Modifying the diffraction wave at the lithotripter aperture can suppress the shockwave-induced bubble cavitation with significant reduced damage potential on the vessel phantom but satisfactory stone comminution ability. PMID:22332839

  15. Drop fragmentation by laser-induced cavitation bubbles

    NASA Astrophysics Data System (ADS)

    Gonzalez-A, S. Roberto; Kerssens, Pjotr; Ohl, Claus-Dieter

    2015-11-01

    The fragmentation of water droplets by a short laser pulse has received significant attention since the 70's. The fundamental understanding of droplet vaporization/fragmentation is of interest in laser beam propagation in the atmosphere, in situ analysis of combustion products -a great concern due to its ecological implications- and more recently driven by a better understanding of the drop shaping by a laser pulse which is of interest in the development of extreme ultraviolet (EUV) machines. In this presentation we discuss about the incipient events that lead to the fragmentation of a drop produced by a cavitation bubble. When the bubble expands, it stretches the drop into a thin liquid film; this liquid film is eventually ruptured and a shockwave and small droplets are ejected as fast as 4 times the speed of sound in air. Interestingly, we also observe bubbles on the surface of the stretched film. Numerical simulations of a shock wave propagating inside a droplet show that cavitation bubbles appear when counter propagating shock waves that rebound from the walls of the drop meet. We also show different fragmentation scenarios recorded with high-speed video, one of them being a jelly fish like liquid film that eventually fragments into smaller drops.

  16. Dynamics and acoustics of a cavitating Venturi flow using a homogeneous air-propylene glycol mixture

    NASA Astrophysics Data System (ADS)

    Navarrete, M.; Naude, J.; Mendez, F.; Godínez, F. A.

    2015-12-01

    Dynamics and acoustics generated in a cavitating Venturi tube are followed up as a function of the input power of a centrifugal pump. The pump of 5 hp with a modified impeller to produce uniform bubbly flow, pumps 70 liters of propylene glycol in a closed loop (with a water cooling system), in which the Venturi is arranged. The goal was to obtain correlations among acoustical emission, dynamics of the shock waves and the light emission from cavitation bubbles. The instrumentation includes: two piezoelectric transducers, a digital camera, a high-speed video camera, and photomultipliers. As results, we show the cavitation patterns as function of the pump power, and a graphical template of the distribution of the Venturi conditions as a function of the cavitation parameter. Our observations show for the first time the sudden formation of bubble clouds in the straight portion of the pipe after the diverging section of the Venturi. We assume that this is due to pre-existing of nuclei-cloud structures which suddenly grow up by the tensile tails of propagating shock waves (producing a sudden drop in pressure).

  17. Physical and chemical effects of acoustic cavitation in selected ultrasonic cleaning applications.

    PubMed

    Yusof, Nor Saadah Mohd; Babgi, Bandar; Alghamdi, Yousef; Aksu, Mecit; Madhavan, Jagannathan; Ashokkumar, Muthupandian

    2016-03-01

    Acoustic cavitation in a liquid medium generates several physical and chemical effects. The oscillation and collapse of cavitation bubbles, driven at low ultrasonic frequencies (e.g., 20 kHz), can generate strong shear forces, microjets, microstreaming and shockwaves. Such strong physical forces have been used in cleaning and flux improvement of ultrafiltration processes. These physical effects have also been shown to deactivate pathogens. The efficiency of deactivation of pathogens is not only dependent on ultrasonic experimental parameters, but also on the properties of the pathogens themselves. Bacteria with thick shell wall are found to be resistant to ultrasonic deactivation process. Some evidence does suggest that the chemical effects (radicals) of acoustic cavitation are also effective in deactivating pathogens. Another aspect of cleaning, namely, purification of water contaminated with organic and inorganic pollutants, has also been discussed in detail. Strong oxidising agents produced within acoustic cavitation bubbles could be used to degrade organic pollutants and convert toxic inorganic pollutants to less harmful substances. The effect of ultrasonic frequency and surface activity of solutes on the sonochemical degradation efficiency has also been discussed in this overview.

  18. The inception of cavitation bubble clouds induced by high-intensity focused ultrasound.

    PubMed

    Chen, Hong; Li, Xiaojing; Wan, Mingxi

    2006-12-22

    In many therapeutic applications of high-intensity focused ultrasound (HIFU) the appearance of cavitation bubbles is unavoidable, whereas the dynamics of the bubbles induced by HIFU have not been clarified. The objective of the present work is to observe the inception process of cavitation bubble clouds generated by HIFU transducer in water using high-speed photography. Sequential images captured within 600 micros after the onset of ultrasound transmission show the dynamics of cavitation bubbles' generation, growth, deformation, expansion and collapse in the focal region. However, when the observation time is narrowed to the initial 145 micros, both the still and streak images reveal that the cavitation bubbles astonishingly stay stable in the focal region for at least 60 micros. The results imply that through adjusting the HIFU exposure time while other physical parameters are appropriately chosen, it might be possible to control the generation of stable cavitation bubbles locally in the focal region.

  19. The inception of cavitation bubble clouds induced by high-intensity focused ultrasound.

    PubMed

    Chen, Hong; Li, Xiaojing; Wan, Mingxi

    2006-12-22

    In many therapeutic applications of high-intensity focused ultrasound (HIFU) the appearance of cavitation bubbles is unavoidable, whereas the dynamics of the bubbles induced by HIFU have not been clarified. The objective of the present work is to observe the inception process of cavitation bubble clouds generated by HIFU transducer in water using high-speed photography. Sequential images captured within 600 micros after the onset of ultrasound transmission show the dynamics of cavitation bubbles' generation, growth, deformation, expansion and collapse in the focal region. However, when the observation time is narrowed to the initial 145 micros, both the still and streak images reveal that the cavitation bubbles astonishingly stay stable in the focal region for at least 60 micros. The results imply that through adjusting the HIFU exposure time while other physical parameters are appropriately chosen, it might be possible to control the generation of stable cavitation bubbles locally in the focal region. PMID:16782158

  20. Prediction of the acoustic and bubble fields in insonified freeze-drying vials.

    PubMed

    Louisnard, O; Cogné, C; Labouret, S; Montes-Quiroz, W; Peczalski, R; Baillon, F; Espitalier, F

    2015-09-01

    The acoustic field and the location of cavitation bubble are computed in vials used for freeze-drying, insonified from the bottom by a vibrating plate. The calculations rely on a nonlinear model of sound propagation in a cavitating liquid [Louisnard, Ultrason. Sonochem., 19, (2012) 56-65]. Both the vibration amplitude and the liquid level in the vial are parametrically varied. For low liquid levels, a threshold amplitude is required to form a cavitation zone at the bottom of the vial. For increasing vibration amplitudes, the bubble field slightly thickens but remains at the vial bottom, and the acoustic field saturates, which cannot be captured by linear acoustics. On the other hand, increasing the liquid level may promote the formation of a secondary bubble structure near the glass wall, a few centimeters below the free liquid surface. These predictions suggest that rather complex acoustic fields and bubble structures can arise even in such small volumes. As the acoustic and bubble fields govern ice nucleation during the freezing step, the final crystal's size distribution in the frozen product may crucially depend on the liquid level in the vial. PMID:25800984

  1. Spatial distribution of sonoluminescence and sonochemiluminescence generated by cavitation bubbles in 1.2 MHz focused ultrasound field.

    PubMed

    Cao, Hua; Wan, Mingxi; Qiao, Yangzi; Zhang, Shusheng; Li, Ruixue

    2012-03-01

    An intensified charge coupled device (ICCD) camera was used to observe the spatial distribution of sonoluminescence (SL) and sonochemiluminescence (SCL) generated by cavitation bubbles in a 1.2 MHz focused ultrasound (FU) field in order to investigate the mechanisms of acoustic cavitation under different sonication conditions for FU therapeutic applications. It was found that SL emissions were located in the post-focal region. When the intensity of SL and SCL increased as the power rose, the growth of SCL was much higher than that of SL. In the post-focal region, the SCL emissions moved along specific paths and formed branch-like streamers. At the beginning of the ultrasound irradiation, cavitation bubbles generated SCL in both the pre-focal and the post-focal region. When the electrical power or the sonication time increased, the SCL in the post-focal region increased and became higher than that in the pre-focal region. The intensity of SCL in the focal region is usually the weakest because of "oversaturation". The spatial distribution of SCL near a tissue boundary differed from that obtained in free fields. It organized into special structures under different acoustic amplitudes. When the electrical power was relatively low, the SCL emission was conical shape which suggested a standing wave formation at the tissue-fluid boundary. When the electrical power exceeded a certain threshold, only a bright spot could be captured in the focus. The cavitation bubbles which centralized in the focus concentrated energy and hindered the formation of standing waves. With rising electrical power at high levels, besides a bright spot in the focus, there were some irregular light spots in pre-focal region, which indicated some cavitation bubbles or small bubble clusters achieved the threshold of SCL and induced the reaction with the luminol solution.

  2. The Minnaert Bubble: An Acoustic Approach

    ERIC Educational Resources Information Center

    Devaud, Martin; Hocquet, Thierry; Bacri, Jean-Claude; Leroy, Valentin

    2008-01-01

    We propose an "ab initio" introduction to the well-known Minnaert pulsating bubble at graduate level. After a brief recall of the standard stuff, we begin with a detailed discussion of the radial movements of an air bubble in water. This discussion is managed from an acoustic point of view, and using the Lagrangian rather than the Eulerian…

  3. Bubble Proliferation or Dissolution of Cavitation Nuclei in the Beam Path of a Shock-Wave Lithotripter

    NASA Astrophysics Data System (ADS)

    Frank, Spencer; Lautz, Jaclyn; Sankin, Georgy N.; Szeri, Andrew J.; Zhong, Pei

    2015-03-01

    It is hypothesized that the decreased treatment efficiency in contemporary shock-wave lithotripters is related to tensile wave attenuation due to cavitation in the prefocal beam path. Utilizing high-speed imaging of the beam path and focal pressure waveform measurements, tensile attenuation is associated with bubble proliferation. By systematically testing different combinations of pulse-repetition frequency and gas concentration, we modulate the bubble-dissolution time to identify which conditions lead to bubble proliferation and show that reducing bubble proliferation in the beam path significantly improves acoustic transmission and stone comminution efficiency in vitro. In addition to experiments, a bubble-proliferation model is developed that takes gas diffusion across the bubble wall and bubble fragmentation into account. By aligning the model with experimental observations, the number of daughter bubbles produced after a single lithotripter bubble collapse is estimated to be in the range of 253 ˜510 . This finding is on the same order of magnitude with previous measurements of an isolated bubble collapse in a lithotripter field by Pishchalnikov, McAteer, and Williams [BJU Int. 102, 1681 (2008), 10.1111/j.1464-410X.2008.07896.x], and this estimate improves the general understanding of lithotripsy bubble dynamics in the beam path.

  4. Bubbly cavitating flow generation and investigation of its erosional nature for biomedical applications.

    PubMed

    Koşar, Ali; Şeşen, Muhsincan; Oral, Ozlem; Itah, Zeynep; Gozuacik, Devrim

    2011-05-01

    This paper presents a study that investigates the destructive energy output resulting from hydrodynamic bubbly cavitation in microchannels and its potential use in biomedical applications. The research performed in this study includes results from bubbly cavitation experiments and findings showing the destructive effects of bubbly cavitating flow on selected solid specimens and live cells. The bubbles generated by hydrodynamic cavitation are highly destructive at the surfaces of the target medium on which they are carefully focused. The resulting destructive energy output could be effectively used for biomedical treatments, such as destroying kidney stones (renal calculi) or killing cancer cells. Motivated by this potential, the cavitation damage to cancerous cells and material removal from chalk pieces (which possess similar material properties as some kidney stones) was investigated. Our results showed that cavitation could induce damage both on chalk pieces and leukemia/lymphoma cells. We discovered that hydrodynamic cavitation exposure had early and delayed effects on cancer cell survival. Hence, the potential of hydrodynamic bubbly cavitation generated at the microscale for biomedical treatments was revealed using the microchannel configuration as a microorifice (with an inner diameter of 147 μm and a length of 1.52 cm), which acts as the source of bubbly cavitating flows.

  5. Cavitation bubble behavior and bubble-shock wave interaction near a gelatin surface as a study of in vivo bubble dynamics

    NASA Astrophysics Data System (ADS)

    Kodama, T.; Tomita, Y.

    The collapse of a single cavitation bubble near a gelatin surface, and the interaction of an air bubble attached to a gelatin surface with a shock wave, were investigated. These events permitted the study of the behavior of in vivo cavitation bubbles and the subsequent tissue damage mechanism during intraocular surgery, intracorporeal and extracorporeal shock wave lithotripsy. Results were obtained with high-speed framing photography. The cavitation bubbles near the gelatin surface did not produce significant liquid jets directed at the surface, and tended to migrate away from it. The period of the motion of a cavitation bubble near the gelatin surface was longer than that of twice the Rayleigh's collapse time for a wide range of relative distance, L/Rmax, excepting for very small L/Rmax values (L was the stand-off distance between the gelatin surface and the laser focus position, and Rmax was the maximum bubble radius). The interaction of an air bubble with a shock wave yielded a liquid jet inside the bubble, penetrating into the gelatin surface. The liquid jet had the potential to damage the gelatin. The results predicted that cavitation-bubble-induced tissue damage was closely related to the oscillatory bubble motion, the subsequent mechanical tissue displacement, and the liquid jet penetration generated by the interaction of the remaining gas bubbles with subsequent shock waves. The characteristic bubble motion and liquid jet formation depended on the tissue's mechanical properties, resulting in different damage mechanisms from those observed on hard materials.

  6. Spatio-temporal dynamics of cavitation bubble clouds in a low frequency reactor: comparison between theoretical and experimental results.

    PubMed

    Servant, G; Laborde, J L; Hita, A; Caltagirone, J P; Gérard, A

    2001-07-01

    The propagation of ultrasound through a liquid induces the growth of inceptions and germs into bubbles. In a low frequency reactor, fragmentary transient bubbles emerge due to the acoustic driving. They violently collapse in one cycle and fragment into many smaller bubbles than in turn cavitate. This violent collapse is responsible for the mechanical effects of ultrasounds effects. The latter bubbles gather in a ball-shaped cloud and migrate to pressure antinodes. During their migration, their nonexplosive collapses mainly contribute to activate chemical reactions by producing OH. radicals. Mathematical modelling is performed as a new approach to predict the bubbles field. Through numerical simulation, we determinate emergence sites of mechanically active cavitation bubbles. Calculus are compared with aluminium foil degradation. The modelling of bubble migration allow us to have an insight on the privileged sites of the chemical reactions. Validation of the modelling is made through direct comparison with chemiluminescence photo. All experiments and computations are made in a 28.2 kHz sonoreactor.

  7. ``Ultrasonic stars'' for time reversal focusing using induced cavitation bubbles

    NASA Astrophysics Data System (ADS)

    Pernot, Mathieu; Montaldo, Gabriel; Tanter, Mickael; Fink, Mathias

    2006-05-01

    Time reversal focusing with ultrasonic arrays is a way to focus waves through heterogeneous media. It requires a reference signal either sent by a small active source embedded in the medium or backscattered by a strong scatterer acting as a passive source. The potential of this method in ultrasonic medical imaging was already envisioned for aberration corrections. However, in many practical situations it is not possible to insert an active source in the medium or to rely on the presence of a unique strong scaterrer at focus in order to generate the reference signal. In analogy with the field of adaptive optics in astronomy, we propose here to create artificial ``ultrasonic stars'' in the body. The trick consists in creating cavitation bubbles inside the medium using one part of the ultrasonic probe. The bubble cavitation generates a spherical wave that propagates through medium heterogeneities to a time reversal array and is used as a reference signal for the time reversal method. This novel method is here experimentally validated for aberrations corrections in tissue mimicking phantoms.

  8. [Cavitation and boiling of bubbles at the focal region during high intensity focused ultrasound exposure].

    PubMed

    Zhong, Mingsong; Ai, Huijian; Li, Faqi

    2012-10-01

    High intensity focused ultrasound (HIFU) is a very complex transient process and can cause tissue coagulation necrosis. The cavitation and boiling behaviour of bubbles in the focal region play very important roles throughout an injury process. This paper reviews the research done by domestic and foreign scholars on behaviours of bubbles in HIFU irradiation process and summarizes in the focal region bubble cavitation and boiling generation, related detective means and relationships with hyperecho, temperature rise of the focus and injury shape.

  9. Synchrotron radiation X-ray imaging of cavitation bubbles in Al-Cu alloy melt.

    PubMed

    Huang, Haijun; Shu, Da; Fu, Yanan; Wang, Jun; Sun, Baode

    2014-07-01

    Cavitation bubbles in Al-10 wt.%Cu melt has been investigated by adopting synchrotron radiation X-ray imaging technology. In-situ observation reveals that most of bubbles concentrate within an intense cavitation zone nearby the radiation face. The measured near-maximum bubble radii obey a similar truncated Gaussian distribution as in water but increase by nearly the magnitude of one order due to higher ultrasonic intensity applied in aluminum melt.

  10. High-contrast active cavitation imaging technique based on multiple bubble wavelet transform.

    PubMed

    Lu, Shukuan; Xu, Shanshan; Liu, Runna; Hu, Hong; Wan, Mingxi

    2016-08-01

    In this study, a unique method that combines the ultrafast active cavitation imaging technique with multiple bubble wavelet transform (MBWT) for improving cavitation detection contrast was presented. The bubble wavelet was constructed by the modified Keller-Miksis equation that considered the mutual effect among bubbles. A three-dimensional spatial model was applied to simulate the spatial distribution of multiple bubbles. The effects of four parameters on the signal-to-noise ratio (SNR) of cavitation images were evaluated, including the following: initial radii of bubbles, scale factor in the wavelet transform, number of bubbles, and the minimum inter-bubble distance. And the other two spatial models and cavitation bubble size distributions were introduced in the MBWT method. The results suggested that in the free-field experiments, the averaged SNR of images acquired by the MBWT method was improved by 7.16 ± 0.09 dB and 3.14 ± 0.14 dB compared with the values of images acquired by the B-mode and single bubble wavelet transform (SBWT) methods. In addition, in the tissue experiments, the averaged cavitation-to-tissue ratio of cavitation images acquired by the MBWT method was improved by 4.69 ± 0.25 dB and 1.74± 0.29 dB compared with that of images acquired by B-mode and SBWT methods.

  11. Experimental investigation on dynamic characteristics and strengthening mechanism of laser-induced cavitation bubbles.

    PubMed

    Ren, X D; He, H; Tong, Y Q; Ren, Y P; Yuan, S Q; Liu, R; Zuo, C Y; Wu, K; Sui, S; Wang, D S

    2016-09-01

    The dynamic features of nanosecond laser-induced cavitation bubbles near the light alloy boundary were investigated with the high-speed photography. The shock-waves and the dynamic characteristics of the cavitation bubbles generated by the laser were detected using the hydrophone. The dynamic features and strengthening mechanism of cavitation bubbles were studied. The strengthening mechanisms of cavitation bubble were discussed when the relative distance parameter γ was within the range of 0.5-2.5. It showed that the strengthening mechanisms caused by liquid jet or shock-waves depended on γ much. The research results provided a new strengthening method based on laser-induced cavitation shotless peening (CSP).

  12. Experimental investigation on dynamic characteristics and strengthening mechanism of laser-induced cavitation bubbles.

    PubMed

    Ren, X D; He, H; Tong, Y Q; Ren, Y P; Yuan, S Q; Liu, R; Zuo, C Y; Wu, K; Sui, S; Wang, D S

    2016-09-01

    The dynamic features of nanosecond laser-induced cavitation bubbles near the light alloy boundary were investigated with the high-speed photography. The shock-waves and the dynamic characteristics of the cavitation bubbles generated by the laser were detected using the hydrophone. The dynamic features and strengthening mechanism of cavitation bubbles were studied. The strengthening mechanisms of cavitation bubble were discussed when the relative distance parameter γ was within the range of 0.5-2.5. It showed that the strengthening mechanisms caused by liquid jet or shock-waves depended on γ much. The research results provided a new strengthening method based on laser-induced cavitation shotless peening (CSP). PMID:27150764

  13. Study on the bubble transport mechanism in an acoustic standing wave field.

    PubMed

    Xi, Xiaoyu; Cegla, Frederic B; Lowe, Michael; Thiemann, Andrea; Nowak, Till; Mettin, Robert; Holsteyns, Frank; Lippert, Alexander

    2011-12-01

    The use of bubbles in applications such as surface chemistry, drug delivery, and ultrasonic cleaning etc. has been enormously popular in the past two decades. It has been recognized that acoustically-driven bubbles can be used to disturb the flow field near a boundary in order to accelerate physical or chemical reactions on the surface. The interactions between bubbles and a surface have been studied experimentally and analytically. However, most of the investigations focused on violently oscillating bubbles (also known as cavitation bubble), less attention has been given to understand the interactions between moderately oscillating bubbles and a boundary. Moreover, cavitation bubbles were normally generated in situ by a high intensity laser beam, little experimental work has been carried out to study the translational trajectory of a moderately oscillating bubble in an acoustic field and subsequent interactions with the surface. This paper describes the design of an ultrasonic test cell and explores the mechanism of bubble manipulation within the test cell. The test cell consists of a transducer, a liquid medium and a glass backing plate. The acoustic field within the multi-layered stack was designed in such a way that it was effectively one dimensional. This was then successfully simulated by a one dimensional network model. The model can accurately predict the impedance of the test cell as well as the mode shape (distribution of particle velocity and stress/pressure field) within the whole assembly. The mode shape of the stack was designed so that bubbles can be pushed from their injection point onto a backing glass plate. Bubble radial oscillation was simulated by a modified Keller-Miksis equation and bubble translational motion was derived from an equation obtained by applying Newton's second law to a bubble in a liquid medium. Results indicated that the bubble trajectory depends on the acoustic pressure amplitude and initial bubble size: an increase of

  14. Bubble proliferation in the cavitation field of a shock wave lithotripter.

    PubMed

    Pishchalnikov, Yuri A; Williams, James C; McAteer, James A

    2011-08-01

    Lithotripter shock waves (SWs) generated in non-degassed water at 0.5 and 2 Hz pulse repetition frequency (PRF) were characterized using a fiber-optic hydrophone. High-speed imaging captured the inertial growth-collapse-rebound cycle of cavitation bubbles, and continuous recording with a 60 fps camcorder was used to track bubble proliferation over successive SWs. Microbubbles that seeded the generation of bubble clouds formed by the breakup of cavitation jets and by bubble collapse following rebound. Microbubbles that persisted long enough served as cavitation nuclei for subsequent SWs, as such bubble clouds were enhanced at fast PRF. Visual tracking suggests that bubble clouds can originate from single bubbles.

  15. Sonoporation of suspension cells with a single cavitation bubble in a microfluidic confinement.

    PubMed

    Gac, Séverine Le; Zwaan, Ed; van den Berg, Albert; Ohl, Claus-Dieter

    2007-12-01

    We report here the sonoporation of HL60 (human promyelocytic leukemia) suspension cells in a microfluidic confinement using a single laser-induced cavitation bubble. Cavitation bubbles can induce membrane poration of cells located in their close vicinity. Membrane integrity of suspension cells placed in a microfluidic chamber is probed through either the calcein release out of calcein-loaded cells or the uptake of trypan blue. Cells that are located farther away than four times Rmax (maximum bubble radius) from the cavitation bubble center remain fully unaffected, while cells closer than 0.75 Rmax become porated with a probability of >75%. These results enable us to define a distance of 0.75 Rmax as a critical interaction distance of the cavitation bubble with HL60 suspension cells. These experiments suggest that flow-induced poration of suspension cells is applicable in lab-on-a-chip systems, and this might be an interesting alternative to electroporation.

  16. Experimental and theoretical studies on the movements of two bubbles in an acoustic standing wave field.

    PubMed

    Jiao, Junjie; He, Yong; Leong, Thomas; Kentish, Sandra E; Ashokkumar, Muthupandian; Manasseh, Richard; Lee, Judy

    2013-10-17

    When subjected to an ultrasonic standing-wave field, cavitation bubbles smaller than the resonance size migrate to the pressure antinodes. As bubbles approach the antinode, they also move toward each other and either form a cluster or coalesce. In this study, the translational trajectory of two bubbles moving toward each other in an ultrasonic standing wave at 22.4 kHz was observed using an imaging system with a high-speed video camera. This allowed the speed of the approaching bubbles to be measured for much closer distances than those reported in the prior literature. The trajectory of two approaching bubbles was modeled using coupled equations of radial and translational motions, showing similar trends with the experimental results. We also indirectly measured the secondary Bjerknes force by monitoring the acceleration when bubbles are close to each other under different acoustic pressure amplitudes. Bubbles begin to accelerate toward each other as the distance between them gets shorter, and this acceleration increases with increasing acoustic pressure. The current study provides experimental data that validates the theory on the movement of bubbles and forces acting between them in an acoustic field that will be useful in understanding bubble coalescence in an acoustic field.

  17. Stress wave emission and cavitation bubble dynamics by nanosecond optical breakdown in a tissue phantom

    NASA Astrophysics Data System (ADS)

    Brujan, Emil-Alexandru; Vogel, Alfred

    2006-07-01

    Stress wave emission and cavitation bubble dynamics after optical breakdown in water and a tissue phantom with Nd: YAG laser pulses of 6 ns duration were investigated both experimentally and numerically to obtain a better understanding of the physical mechanisms involved in plasma-mediated laser surgery. Experimental tools were high-speed photography with 50000 frames s(-1) , and acoustic measurements. The tissue phantom consisted of a transparent polyacrylamide (PAA) gel, the elastic properties of which can be controlled by modifying the water content. Breakdown in water produced a purely compressive stress wave. By contrast, in stiff PAA samples and for sufficiently large pulse energies, the compression wave was followed by an intense tensile wave, similar to the behaviour previously observed in cornea. The elastic/plastic response of the medium led to a significant decrease of the maximum size of the cavitation bubble and to a shortening of its oscillation period which was found to be related to the generation of the tensile stress wave upon breakdown. For increasing elastic modulus of the PAA, both the amplitudes of the bubble oscillation and of the stress wave emitted during bubble collapse decreased until the bubble oscillation was so strongly damped that no collapse stress wave was emitted. Numerical simulations were performed using a spherical model of bubble dynamics which includes the compressibility and elastic/plastic behaviour of the medium, viscosity, density and surface tension. The calculations revealed that consideration of the elastic/plastic behaviour of the medium surrounding the bubble is essential to describe the experimentally observed bipolar shape of the stress wave emitted upon optical breakdown. Water is a poor tissue model because the shape of the emitted stress waves and the bubble dynamics differ strongly for both materials. The mechanical properties of PAA were also found to be quite different from those of tissues. Experimental and

  18. Resonance fluorescence spectroscopy in laser-induced cavitation bubbles.

    PubMed

    Koch, Sandra; Garen, Walter; Neu, Walter; Reuter, Rainer

    2006-05-01

    Laser-induced breakdown spectroscopy (LIBS) in liquids using a double-pulse Q-switched Nd:YAG laser system has provided reliable results that give trace detection limits in water. Resonant laser excitation has been added to enhance detection sensitivity. A primary laser pulse (at 532 nm), transmitted via an optical fiber, induces a cavitation bubble and shockwave at a target immersed in a 10 mg l(-1)-100 mg l(-1) indium (In) water suspension. The low-pressure rear of the shockwave induces bubble expansion and a resulting reduction in cavity pressure as it extends away from the target. Shortly before the maximum diameter is expected, a secondary laser pulse (also at 532 nm) is fed into the bubble in order to reduce quenching processes. The plasma field generated is then resonantly excited by a fiber-guided dye laser beam to increase detection selectivity. The resulting resonance fluorescence emission is optically detected and processed by an intensified optical multichannel analyzer system.

  19. Acoustic Behavior of Vapor Bubbles

    NASA Technical Reports Server (NTRS)

    Prosperetti, Andrea; Oguz, Hasan N.

    1996-01-01

    In a microgravity environment vapor bubbles generated at a boiling surface tend to remain near it for a long time. This affects the boiling heat transfer and in particular promotes an early transition to the highly inefficient film boiling regime. This paper describes the physical basis underlying attempts to remove the bubbles by means of pressure radiation forces.

  20. Experimental and theoretical study on cavitation inception and bubbly flow dynamics. Part 1: Design, development and operation of a cavitation susceptibility meter. Part 2: Linearized dynamics of bubbly and cavitating flows with bubble dynamics effects

    NASA Astrophysics Data System (ADS)

    Dagostino, Luca

    1987-05-01

    This theses presents the design, development and operations of a Cavitation Susceptibility Meter based on the use of a venturi tube for the measurement of the content of active cavitation nuclei in water samples. The pressure at the venturi throat is determined from the upstream pressure and the local flow velocity without corrections for viscous effects because the flow possesses a laminar potential core in all operational conditions. The detection ov cavitation and the measurement of the flow velocity are carried out optically. The apparatus comprises a Laser Doppler Velocimeter for the measurement of the flow velocity and the detection of cavitation, a custom-made electronic Signal Processor for real time generation and temporary storage of the data and a computerized system for the final acquisition and reduction of the collected data. The results of application of the Cavitation Susceptibility Meter to the measurement of the water quality of the tap water samples are presented. The results of an investigation are presented on the linearized dynamics of two-phase bubbly flows with the inclusion of bubble dynamics effects. Two flow configurations have been studied: the time dependent one-dimensional flow of a spherical bubble cloud subject to harmonic excitation of the far field external pressure and the steady state two-dimensional flow of a bubbly mixture on a slender profile of arbitrary shape.

  1. Characterization of acoustic cavitation in water and molten aluminum alloy.

    PubMed

    Komarov, Sergey; Oda, Kazuhiro; Ishiwata, Yasuo; Dezhkunov, Nikolay

    2013-03-01

    High-intensive ultrasonic vibrations have been recognized as an attractive tool for refining the grain structure of metals in casting technology. However, the practical application of ultrasonics in this area remains rather limited. One of the reasons is a lack of data needed to optimize the ultrasonic treatment conditions, particularly those concerning characteristics of cavitation zone in molten aluminum. The main aim of the present study was to investigate the intensity and spectral characteristics of cavitation noise generated during radiation of ultrasonic waves into water and molten aluminum alloys, and to establish a measure for evaluating the cavitation intensity. The measurements were performed by using a high temperature cavitometer capable of measuring the level of cavitation noise within five frequency bands from 0.01 to 10MHz. The effect of cavitation treatment was verified by applying high-intense ultrasonic vibrations to a DC caster to refine the primary silicon grains of a model Al-17Si alloy. It was found that the level of high frequency noise components is the most adequate parameter for evaluating the cavitation intensity. Based on this finding, it was concluded that implosions of cavitation bubbles play a decisive role in refinement of the alloy structure.

  2. Effects of ultrasound frequency and acoustic amplitude on the size of sonochemically active bubbles - Theoretical study.

    PubMed

    Merouani, Slimane; Hamdaoui, Oualid; Rezgui, Yacine; Guemini, Miloud

    2013-05-01

    Numerical simulation of chemical reactions inside an isolated spherical bubble of oxygen has been performed for various ambient bubble radii at different frequencies and acoustic amplitudes to study the effects of these two parameters on the range of ambient radius for an active bubble in sonochemical reactions. The employed model combines the dynamic of bubble collapse with the chemical kinetics of single cavitation bubble. Results from this model were compared with some experimental results presented in the literature and good apparent trends between them were observed. The numerical calculations of this study showed that there always exists an optimal ambient bubble radius at which the production of oxidizing species at the end of the bubble collapse attained their upper limit. It was shown that the range of ambient radius for an active bubble increased with increasing acoustic amplitude and decreased with increasing ultrasound frequency. The optimal ambient radius decreased with increasing frequency. Analysis of curves showing optimal ambient radius versus acoustic amplitude for different ultrasonic frequencies indicated that for 200 and 300kHz, the optimal ambient radius increased linearly with increasing acoustic amplitude up to 3atm. However, slight minima of optimal radius were observed for the curves obtained at 500 and 1000kHz. PMID:23187064

  3. Cavitation microstreaming generated by a bubble pair in an ultrasound field.

    PubMed

    Wang, Chenghui; Cheng, Jianchun

    2013-08-01

    An analytical theory has been developed to calculate the acoustic streaming velocity inside and outside bubbles for the case of a bubble pair suspended in an unbounded viscous liquid, taking into account the two predominant modes of a bubble pair: The volume and translation modes. It was demonstrated that the interaction between bubbles can affect the magnitude and direction of acoustic streaming, especially for tangential components outside of bubbles. The acoustic streaming intensifies as the radius of the neighboring bubble increases and is weakened as the distance between the bubbles increases.

  4. Reconstruction of laser-induced cavitation bubble dynamics based on a Fresnel propagation approach.

    PubMed

    Devia-Cruz, Luis Felipe; Camacho-López, Santiago; Cortés, Víctor Ruiz; Ramos-Muñiz, Victoria; Pérez-Gutiérrez, Francisco G; Aguilar, Guillermo

    2015-12-10

    A single laser-induced cavitation bubble in transparent liquids has been studied through a variety of experimental techniques. High-speed video with varying frame rate up to 20×10(7)   fps is the most suitable to study nonsymmetric bubbles. However, it is still expensive for most researchers and more affordable (lower) frame rates are not enough to completely reproduce bubble dynamics. This paper focuses on combining the spatial transmittance modulation (STM) technique, a single shot cavitation bubble and a very simple and inexpensive experimental technique, based on Fresnel approximation propagation theory, to reproduce a laser-induced cavitation spatial dynamics. Our results show that the proposed methodology reproduces a laser-induced cavitation event much more accurately than 75,000 fps video recording. In conclusion, we propose a novel methodology to reproduce laser-induced cavitation events that combine the STM technique with Fresnel propagation approximation theory that properly reproduces a laser-induced cavitation event including a very precise identification of the first, second, and third collapses of the cavitation bubble. PMID:26836867

  5. Electromagnetic acoustic source (EMAS) for generating shock waves and cavitation in mercury

    NASA Astrophysics Data System (ADS)

    Wang, Qi

    In the Spallation Neutron Source (SNS) at Oak Ridge National Laboratory a vessel of liquid mercury is subjected to a proton beam. The resulting nuclear interaction produces neutrons that can be used for materials research, among other things, but also launches acoustic waves with pressures in excess of 10 MPa. The acoustic waves have high enough tensile stress to generate cavitation in the mercury which results in erosion to the steel walls of the vessel. In order to study the cavitation erosion and develop mitigation schemes it would be convenient to have a way of generating similar pressures and cavitation in mercury, without the radiation concerns associated with a proton beam. Here an electromagnetic acoustic source (EMAS) has been developed which consisted of a coil placed close to a metal plate which is in turn is in contact with a fluid. The source is driven by discharging a capacitor through the coil and results in a repulsive force on the plate launching acoustic waves in the fluid. A theoretical model is presented to predict the acoustic field from the EMAS and compares favorably with measurements made in water. The pressure from the EMAS was reported as a function of capacitance, charging voltage, number of coils, mylar thickness, and properties of the plates. The properties that resulted in the highest pressure were employed for experiments in mercury and a maximum pressure recorded was 7.1 MPa. Cavitation was assessed in water and mercury by high speed camera and by detecting acoustic emissions. Bubble clouds with lifetimes on the order of 100 µs were observed in water and on the order of 600 µs in mercury. Based on acoustic emissions the bubble radius in mercury was estimated to be 0.98 mm. Experiments to produce damage to a stainless steel plate in mercury resulted in a minimal effect after 2000 shock waves at a rate of 0.33 Hz - likely because the pressure amplitude was not high enough. In order to replicate the conditions in the SNS it is

  6. Acoustic Scattering from Compact Bubble Clouds.

    NASA Astrophysics Data System (ADS)

    Schindall, Jeffrey Alan

    In this study, a simple model describing the low -frequency scattering properties of high void fraction bubble clouds in both the free field and near the ocean surface is developed. This model, which is based on an effective medium approximation and acoustically compact scatters, successfully predicts the results of the bubble cloud scattering experiment carried out at Lake Seneca in New York state for frequencies consistent with the model assumptions (Roy et al., 1992). The introduction of the surface is facilitated by the method of images and is subject to the same constraint of low-acoustic frequency imposed by the compact scatterer assumption. This model is not intended to serve as an exact replicate of oceanic bubble cloud scattering. The model herein was kept simple by design, for only then can the complex physical behavior be expressed in a simple analytical form. Simple, analytic theories facilitate the exploration of parameter space, and more importantly serve to illuminate the underlying physics.

  7. Acceleration of lithotripsy using cavitation bubbles induced by second-harmonic superimposition

    NASA Astrophysics Data System (ADS)

    Osuga, Masamizu; Yasuda, Jun; Jimbo, Hayato; Yoshizawa, Shin; Umemura, Shin-ichiro

    2016-07-01

    Shock wave lithotripsy potentially produces residual stone fragments too large to pass through ureters and significant injury to the normal tissue surrounding the stone. Previous works have shown that the collapse of cavitation bubbles induced by high-intensity focused ultrasound can produce small stone fragments via cavitation erosion. However, the erosion rate is hypothesized to be reduced by ultrasound attenuation by excessively generated bubble clouds. If so, it is important to generate the bubbles only on the stone surface. The effects of peak-negative-enhanced (PNE) and peak-positive-enhanced (PPE) waves obtained by second-harmonic superimposition were investigated to control cavitation bubbles. With the PNE waves, the bubbles were generated only on the stone surface and the maximum erosion rate was 232 ± 32 mg/min. All the fragments were smaller than 2 mm, which makes them pass through ureters naturally. The proposed method shows the potential to significantly improve the speed of lithotripsy.

  8. Enhancing the aggressive intensity of hydrodynamic cavitation through a Venturi tube by increasing the pressure in the region where the bubbles collapse

    NASA Astrophysics Data System (ADS)

    Soyama, H.; Hoshino, J.

    2016-04-01

    In this paper, we used a Venturi tube for generating hydrodynamic cavitation, and in order to obtain the optimum conditions for this to be used in chemical processes, the relationship between the aggressive intensity of the cavitation and the downstream pressure where the cavitation bubbles collapse was investigated. The acoustic power and the luminescence induced by the bubbles collapsing were investigated under various cavitating conditions, and the relationships between these and the cavitation number, which depends on the upstream pressure, the downstream pressure at the throat of the tube and the vapor pressure of the test water, was found. It was shown that the optimum downstream pressure, i.e., the pressure in the region where the bubbles collapse, increased the aggressive intensity by a factor of about 100 compared to atmospheric pressure without the need to increase the input power. Although the optimum downstream pressure varied with the upstream pressure, the cavitation number giving the optimum conditions was constant for all upstream pressures.

  9. Pseudopotential multi-relaxation-time lattice Boltzmann model for cavitation bubble collapse with high density ratio

    NASA Astrophysics Data System (ADS)

    Shan, Ming-Lei; Zhu, Chang-Ping; Yao, Cheng; Yin, Cheng; Jiang, Xiao-Yan

    2016-10-01

    The dynamics of the cavitation bubble collapse is a fundamental issue for the bubble collapse application and prevention. In the present work, the modified forcing scheme for the pseudopotential multi-relaxation-time lattice Boltzmann model developed by Li Q et al. [Li Q, Luo K H and Li X J 2013 Phys. Rev. E 87 053301] is adopted to develop a cavitation bubble collapse model. In the respects of coexistence curves and Laplace law verification, the improved pseudopotential multi-relaxation-time lattice Boltzmann model is investigated. It is found that the thermodynamic consistency and surface tension are independent of kinematic viscosity. By homogeneous and heterogeneous cavitation simulation, the ability of the present model to describe the cavitation bubble development as well as the cavitation inception is verified. The bubble collapse between two parallel walls is simulated. The dynamic process of a collapsing bubble is consistent with the results from experiments and simulations by other numerical methods. It is demonstrated that the present pseudopotential multi-relaxation-time lattice Boltzmann model is applicable and efficient, and the lattice Boltzmann method is an alternative tool for collapsing bubble modeling. Project supported by the National Natural Science Foundation of China (Grant Nos. 11274092 and 1140040119) and the Natural Science Foundation of Jiangsu Province, China (Grant No. SBK2014043338).

  10. High-speed observation of cavitation bubble clouds near a tissue boundary in high-intensity focused ultrasound fields.

    PubMed

    Chen, Hong; Li, Xiaojing; Wan, Mingxi; Wang, Supin

    2009-03-01

    Cavitation bubble clouds generated near a tissue boundary by high-intensity focused ultrasound (HIFU) were studied using high-speed photography. In all, 171 image series were captured during the initial 100 ms of continuous HIFU exposure, which showed that cavitation bubble clouds at the tissue boundary organized into two structures - "cone-shape bubble cloud structure" recorded in 146 image series and "crown-shape bubble cloud structure" recorded in 18 image series. The remaining 7 image series showed the interchanging of these two structures. It was found that when cavitation bubbles first appeared at the tissue boundary, they developed to cone-shape bubble cloud. The cone-shape bubble cloud structure was characterized by a nearly fixed tip in front of the tissue boundary. When the cavitation bubbles initially appeared away from the tissue boundary they evolved into a crown-shape bubble cloud. Deformation of tissue boundary was shown in all the recorded image series.

  11. High-speed observation of cavitation bubble clouds near a tissue boundary in high-intensity focused ultrasound fields.

    PubMed

    Chen, Hong; Li, Xiaojing; Wan, Mingxi; Wang, Supin

    2009-03-01

    Cavitation bubble clouds generated near a tissue boundary by high-intensity focused ultrasound (HIFU) were studied using high-speed photography. In all, 171 image series were captured during the initial 100 ms of continuous HIFU exposure, which showed that cavitation bubble clouds at the tissue boundary organized into two structures - "cone-shape bubble cloud structure" recorded in 146 image series and "crown-shape bubble cloud structure" recorded in 18 image series. The remaining 7 image series showed the interchanging of these two structures. It was found that when cavitation bubbles first appeared at the tissue boundary, they developed to cone-shape bubble cloud. The cone-shape bubble cloud structure was characterized by a nearly fixed tip in front of the tissue boundary. When the cavitation bubbles initially appeared away from the tissue boundary they evolved into a crown-shape bubble cloud. Deformation of tissue boundary was shown in all the recorded image series. PMID:19041998

  12. Controlled, forced collapse of cavitation bubbles for improved stone fragmentation during shock wave lithotripsy.

    PubMed

    Zhong, P; Cocks, F H; Cioanta, I; Preminger, G M

    1997-12-01

    The feasibility of using controlled, forced collapse of cavitation bubbles for improved stone fragmentation during shock wave lithotripsy was demonstrated using microsecond tandem shockwave pulses. High-speed photography revealed that a secondary shock wave, released in less than 500 microseconds (microsec.) following a lithotripter-generated shock wave, can be used to control and force the collapse of cavitation bubbles toward target concretions. This timely enforced shockwave-bubble interaction was found to greatly enhance the cavitational activity near the stone surface, with a resultant up to 43% increment in stone fragmentation. Since most of the cavitation energy is directed and concentrated toward the target stones and fewer shock waves are needed for successful stone comminution, tissue injury associated with this new lithotripsy procedure may also be reduced. This novel concept of shock wave lithotripsy may be used to improve the treatment efficiency and safety of existing clinical lithotripters, as well as in the design of new shock wave lithotripters.

  13. High-contrast active cavitation imaging technique based on multiple bubble wavelet transform.

    PubMed

    Lu, Shukuan; Xu, Shanshan; Liu, Runna; Hu, Hong; Wan, Mingxi

    2016-08-01

    In this study, a unique method that combines the ultrafast active cavitation imaging technique with multiple bubble wavelet transform (MBWT) for improving cavitation detection contrast was presented. The bubble wavelet was constructed by the modified Keller-Miksis equation that considered the mutual effect among bubbles. A three-dimensional spatial model was applied to simulate the spatial distribution of multiple bubbles. The effects of four parameters on the signal-to-noise ratio (SNR) of cavitation images were evaluated, including the following: initial radii of bubbles, scale factor in the wavelet transform, number of bubbles, and the minimum inter-bubble distance. And the other two spatial models and cavitation bubble size distributions were introduced in the MBWT method. The results suggested that in the free-field experiments, the averaged SNR of images acquired by the MBWT method was improved by 7.16 ± 0.09 dB and 3.14 ± 0.14 dB compared with the values of images acquired by the B-mode and single bubble wavelet transform (SBWT) methods. In addition, in the tissue experiments, the averaged cavitation-to-tissue ratio of cavitation images acquired by the MBWT method was improved by 4.69 ± 0.25 dB and 1.74± 0.29 dB compared with that of images acquired by B-mode and SBWT methods. PMID:27586732

  14. Nonlinear Bubble Interactions in Acoustic Pressure Fields

    NASA Technical Reports Server (NTRS)

    Barbat, Tiberiu; Ashgriz, Nasser; Liu, Ching-Shi

    1996-01-01

    The systems consisting of a two-phase mixture, as clouds of bubbles or drops, have shown many common features in their responses to different external force fields. One of particular interest is the effect of an unsteady pressure field applied to these systems, case in which the coupling of the vibrations induced in two neighboring components (two drops or two bubbles) may result in an interaction force between them. This behavior was explained by Bjerknes by postulating that every body that is moving in an accelerating fluid is subjected to a 'kinetic buoyancy' equal with the product of the acceleration of the fluid multiplied by the mass of the fluid displaced by the body. The external sound wave applied to a system of drops/bubbles triggers secondary sound waves from each component of the system. These secondary pressure fields integrated over the surface of the neighboring drop/bubble may result in a force additional to the effect of the primary sound wave on each component of the system. In certain conditions, the magnitude of these secondary forces may result in significant changes in the dynamics of each component, thus in the behavior of the entire system. In a system containing bubbles, the sound wave radiated by one bubble at the location of a neighboring one is dominated by the volume oscillation mode and its effects can be important for a large range of frequencies. The interaction forces in a system consisting of drops are much smaller than those consisting of bubbles. Therefore, as a first step towards the understanding of the drop-drop interaction subject to external pressure fluctuations, it is more convenient to study the bubble interactions. This paper presents experimental results and theoretical predictions concerning the interaction and the motion of two levitated air bubbles in water in the presence of an acoustic field at high frequencies (22-23 KHz).

  15. Cavitation damage prediction for spallation target vessels by assessment of acoustic vibration

    SciTech Connect

    Futakawa, Masatoshi; Kogawa, Hiroyuki; Hasegawa, Shoichi; Ikeda, Dr. Yujiro; Riemer, Bernie; Wendel, Mark W; Haines, John R; Bauer, Guenter; Naoe, Dr. Takashi; Okita, Dr. Kohei; Fujiwara, Dr. Akiko; Matsumoto, Dr. Yoichiro; Tanaka, Dr. Nobuatsu

    2008-01-01

    Liquid-mercury target systems for MW-class spallation neutron sources are being developed around the world. Proton beams are used to induce the spallation reaction. At the moment the proton beam hits the target, pressure waves are generated in the mercury because of the abrupt heat deposition. The pressure waves interact with the target vessel leading to negative pressure that may cause cavitation along the vessel wall. In order to estimate the cavitation erosion, i.e. the pitting damage formed by the collapse of cavitation bubbles, off-beam tests were performed by using an electric magnetic impact testing machine (MIMTM), which can impose equivalent pressure pulses in mercury. The damage potential was defined based on the relationship between the pitting damage and the time-integrated acoustic vibration induced by impact due to the bubble collapses. Additionally, the damage potential was measured in on-beam tests carried out by using the proton beam at WNR (Weapons Neutron Research) facility in Los Alamos Neutron Science Center (LANSCE). In this paper, the concept of the damage potential, the relationship between the pitting damage formation and the damage potential both in off-beam and on-beam tests is shown.

  16. A numerical method for the dynamics of non-spherical cavitation bubbles

    NASA Technical Reports Server (NTRS)

    Lucca, G.; Prosperetti, A.

    1982-01-01

    A boundary integral numerical method for the dynamics of nonspherical cavitation bubbles in inviscid incompressible liquids is described. Only surface values of the velocity potential and its first derivatives are involved. The problem of solving the Laplace equation in the entire domain occupied by the liquid is thus avoided. The collapse of a bubble in the vicinity of a solid wall and the collapse of three bubbles with collinear centers are considered.

  17. Dynamics of shock waves and cavitation bubbles in bilinear elastic-plastic media, and the implications to short-pulsed laser surgery

    NASA Astrophysics Data System (ADS)

    Brujan, E.-A.

    2005-01-01

    The dynamics of shock waves and cavitation bubbles generated by short laser pulses in water and elastic-plastic media were investigated theoretically in order to get a better understanding of their role in short-pulsed laser surgery. Numerical simulations were performed using a spherical model of bubble dynamics which include the elastic-plastic behaviour of the medium surrounding the bubble, compressibility, viscosity, density and surface tension. Breakdown in water produces a monopolar acoustic signal characterized by a compressive wave. Breakdown in an elastic-plastic medium produces a bipolar acoustic signal, with a leading positive compression wave and a trailing negative tensile wave. The calculations revealed that consideration of the tissue elasticity is essential to describe the bipolar shape of the shock wave emitted during optical breakdown. The elastic-plastic response of the medium surrounding the bubble leads to a significant decrease of the maximum size of the cavitation bubble and pressure amplitude of the shock wave emitted during bubble collapse, and shortening of the oscillation period of the bubble. The results are discussed with respect to collateral damage in short-pulsed laser surgery.

  18. A New Active Cavitation Mapping Technique for Pulsed HIFU Applications – Bubble Doppler

    PubMed Central

    Li, Tong; Khokhlova, Tatiana; Sapozhnikov, Oleg; Hwang, Joo Ha; Sapozhnikov, Oleg; O’Donnell, Matthew

    2015-01-01

    In this work, a new active cavitation mapping technique for pulsed high-intensity focused ultrasound (pHIFU) applications termed bubble Doppler is proposed and its feasibility tested in tissue-mimicking gel phantoms. pHIFU therapy uses short pulses, delivered at low pulse repetition frequency, to cause transient bubble activity that has been shown to enhance drug and gene delivery to tissues. The current gold standard for detecting and monitoring cavitation activity during pHIFU treatments is passive cavitation detection (PCD), which provides minimal information on the spatial distribution of the bubbles. B-mode imaging can detect hyperecho formation, but has very limited sensitivity, especially to small, transient microbubbles. The bubble Doppler method proposed here is based on a fusion of the adaptations of three Doppler techniques that had been previously developed for imaging of ultrasound contrast agents – color Doppler, pulse inversion Doppler, and decorrelation Doppler. Doppler ensemble pulses were interleaved with therapeutic pHIFU pulses using three different pulse sequences and standard Doppler processing was applied to the received echoes. The information yielded by each of the techniques on the distribution and characteristics of pHIFU-induced cavitation bubbles was evaluated separately, and found to be complementary. The unified approach - bubble Doppler – was then proposed to both spatially map the presence of transient bubbles and to estimate their sizes and the degree of nonlinearity. PMID:25265178

  19. Robust Acoustic Transducers for Bubble Chambers

    NASA Astrophysics Data System (ADS)

    Wells, Jonathan

    2015-04-01

    The PICO collaboration utilizes bubble chambers filled with various superheated liquids as targets for dark matter. Acoustic sensors have proved able to distinguish nuclear recoils from radioactive background on an event-by-event basis. We have recently produced a more robust transducer which should be able to operate for years, rather than months, in the challenging environment of a heated high pressure hydraulic fluid outside these chambers. Indiana University South Bend.

  20. Gaseous bubble oscillations in anisotropic non-Newtonian fluids under influence of high-frequency acoustic field

    NASA Astrophysics Data System (ADS)

    Golykh, R. N.

    2016-06-01

    Progress of technology and medicine dictates the ever-increasing requirements (heat resistance, corrosion resistance, strength properties, impregnating ability, etc.) for non-Newtonian fluids and materials produced on their basis (epoxy resin, coating materials, liquid crystals, etc.). Materials with improved properties obtaining is possible by modification of their physicochemical structure. One of the most promising approaches to the restructuring of non-Newtonian fluids is cavitation generated by high-frequency acoustic vibrations. The efficiency of cavitation in non-Newtonian fluid is determined by dynamics of gaseous bubble. Today, bubble dynamics in isotropic non-Newtonian fluids, in which cavitation bubble shape remains spherical, is most full investigated, because the problem reduces to ordinary differential equation for spherical bubble radius. However, gaseous bubble in anisotropic fluids which are most wide kind of non-Newtonian fluids (due to orientation of macromolecules) deviates from spherical shape due to viscosity dependence on shear rate direction. Therefore, the paper presents the mathematical model of gaseous bubble dynamics in anisotropic non-Newtonian fluids. The model is based on general equations for anisotropic non-Newtonian fluid flow. The equations are solved by asymptotic decomposition of fluid flow parameters. It allowed evaluating bubble size and shape evolution depending on rheological properties of liquid and acoustic field characteristics.

  1. Acoustic bubble sizes, coalescence, and sonochemical activity in aqueous electrolyte solutions saturated with different gases.

    PubMed

    Brotchie, Adam; Statham, Tom; Zhou, Meifang; Dharmarathne, Leena; Grieser, Franz; Ashokkumar, Muthupandian

    2010-08-01

    Acoustic bubble sizes, coalescence behavior, and sonochemical activity have been investigated in water in the presence of various electrolyte additives (KCl, HCl, and NaNO(3)) and saturating gases-helium, air, and argon. A strong correlation was identified between the bubble radius and the dissolved gas concentration in the cavitation medium. The extent of bubble coalescence for each gas was also studied in different electrolyte solutions. A causal relationship between coalescence and bubble size was inferred. Importantly, the effects of the different electrolytes could be completely attributed to their "salting out" effect on the dissolved gas, providing valuable insight into the contentious issue of ion-specific coalescence inhibition. Extrapolation of the bubble size data to conditions where bubble coalescence is minimal, i.e., zero gas concentration and zero ultrasound exposure time, yielded a bubble radius of 1.5 +/- 0.5 microm at an acoustic frequency of 515 kHz. In addition, the effects of electrolyte concentration and gas type on sonochemical activity were investigated. Sonochemical yields were increased by up to 1 order of magnitude at high electrolyte concentrations. This has been attributed to reduced gas and vapor content in the bubble core prior to collapse and a lower clustering density.

  2. Measurement of Bubble Size Distribution Based on Acoustic Propagation in Bubbly Medium

    NASA Astrophysics Data System (ADS)

    Wu, Xiongjun; Hsiao, Chao-Tsung; Choi, Jin-Keun; Chahine, Georges

    2013-03-01

    Acoustic properties are strongly affected by bubble size distribution in a bubbly medium. Measurement of the acoustic transmission becomes increasingly difficulty as the void fraction of the bubbly medium increases due to strong attenuation, while acoustic reflection can be measured more easily with increasing void fraction. The ABS ACOUSTIC BUBBLE SPECTROMETER®\\copyright, an instrument for bubble size measurement that is under development tries to take full advantage of the properties of acoustic propagation in bubbly media to extract bubble size distribution. Properties of both acoustic transmission and reflection in the bubbly medium from a range of short single-frequency bursts of acoustic waves at different frequencies are measured in an effort to deduce the bubble size distribution. With the combination of both acoustic transmission and reflection, assisted with validations from photography, the ABS ACOUSTIC BUBBLE SPECTROMETER®\\copyright has the potential to measure bubble size distributions in a wider void fraction range. This work was sponsored by Department of Energy SBIR program

  3. The Role of Acoustic Cavitation in Ultrasound-triggered Drug Release from Echogenic Liposomes

    NASA Astrophysics Data System (ADS)

    Kopechek, Jonathan A.

    Cardiovascular disease (CVD) is the leading cause of death in the United States and globally. CVD-related mortality, including coronary heart disease, heart failure, or stroke, generally occurs due to atherosclerosis, a condition in which plaques build up within arterial walls, potentially causing blockage or rupture. Targeted therapies are needed to achieve more effective treatments. Echogenic liposomes (ELIP), which consist of a lipid membrane surrounding an aqueous core, have been developed to encapsulate a therapeutic agent and/or gas bubbles for targeted delivery and ultrasound image enhancement. Under certain conditions ultrasound can cause nonlinear bubble growth and collapse, known as "cavitation." Cavitation activity has been associated with enhanced drug delivery across cellular membranes. However, the mechanisms of ultrasound-mediated drug release from ELIP have not been previously investigated. Thus, the objective of this dissertation is to elucidate the role of acoustic cavitation in ultrasound-mediated drug release from ELIP. To determine the acoustic and physical properties of ELIP, the frequency-dependent attenuation and backscatter coefficients were measured between 3 and 30 MHz. The results were compared to a theoretical model by measuring the ELIP size distribution in order to determine properties of the lipid membrane. It was found that ELIP have a broad size distribution and can provide enhanced ultrasound image contrast across a broad range of clinically-relevant frequencies. Calcein, a hydrophilic fluorescent dye, and papaverine, a lipophilic vasodilator, were separately encapsulated in ELIP and exposed to color Doppler ultrasound pulses from a clinical diagnostic ultrasound scanner in a flow system. Spectrophotometric techniques (fluorescence and absorbance measurements) were used to detect calcein or papaverine release. As a positive control, Triton X-100 (a non-ionic detergent) was added to ELIP samples not exposed to ultrasound in order

  4. Numerical simulation of cavitation erosion on a NACA0015 hydrofoil based on bubble collapse strength

    NASA Astrophysics Data System (ADS)

    Hidalgo, V.; Luo, X.; Escaler, X.; Huang, R.; Valencia, E.

    2015-12-01

    The prediction of erosion under unsteady cavitation is crucial to prevent damage in hydraulic machinery. The present investigation deals with the numerical simulation of erosive partial cavitation around a NACA0015 hydrofoil. The study presents the calculation of the bubble collapse strength, Sb, based on the bubble potential energy to identify the surface areas with highest risk of damage. The results are obtained with a numerical scheme assuming homogeneous mixture flow, implicit LES and Zwart cavitation model. The 3D unsteady flow simulation has been solved using OpenFOAM. Python language and OpenFOAM calculator (foamCalcEx) have been used to obtain and represent Sb. The obtained results clearly show the instants of erosive bubble collapse and the affected surface areas.

  5. Theoretical estimation of the temperature and pressure within collapsing acoustical bubbles.

    PubMed

    Merouani, Slimane; Hamdaoui, Oualid; Rezgui, Yacine; Guemini, Miloud

    2014-01-01

    Formation of highly reactive species such as OH, H, HO2 and H2O2 due to transient collapse of cavitation bubbles is the primary mechanism of sonochemical reaction. The crucial parameters influencing the formation of radicals are the temperature and pressure achieved in the bubble during the strong collapse. Experimental determinations estimated a temperature of about 5000 K and pressure of several hundreds of MPa within the collapsing bubble. In this theoretical investigation, computer simulations of chemical reactions occurring in an O2-bubble oscillating in water irradiated by an ultrasonic wave have been performed for diverse combinations of various parameters such as ultrasound frequency (20-1000 kHz), acoustic amplitude (up to 0.3 MPa), static pressure (0.03-0.3 MPa) and liquid temperature (283-333 K). The aim of this series of computations is to correlate the production of OH radicals to the temperature and pressure achieved in the bubble during the strong collapse. The employed model combines the dynamic of bubble collapse in acoustical field with the chemical kinetics of single bubble. The results of the numerical simulations revealed that the main oxidant created in an O2 bubble is OH radical. The computer simulations clearly showed the existence of an optimum bubble temperature of about 5200±200 K and pressure of about 250±20 MPa. The predicted value of the bubble temperature for the production of OH radicals is in excellent agreement with that furnished by the experiments. The existence of an optimum bubble temperature and pressure in collapsing bubbles results from the competitions between the reactions of production and those of consumption of OH radicals at high temperatures. PMID:23769748

  6. Effects of acoustic parameters on bubble cloud dynamics in ultrasound tissue erosion (histotripsy).

    PubMed

    Xu, Zhen; Hall, Timothy L; Fowlkes, J Brian; Cain, Charles A

    2007-07-01

    High intensity pulsed ultrasound can produce significant mechanical tissue fractionation with sharp boundaries ("histotripsy"). At a tissue-fluid interface, histotripsy produces clearly demarcated tissue erosion and the erosion efficiency depends on pulse parameters. Acoustic cavitation is believed to be the primary mechanism for the histotripsy process. To investigate the physical basis of the dependence of tissue erosion on pulse parameters, an optical method was used to monitor the effects of pulse parameters on the cavitating bubble cloud generated by histotripsy pulses at a tissue-water interface. The pulse parameters studied include pulse duration, peak rarefactional pressure, and pulse repetition frequency (PRF). Results show that the duration of growth and collapse (collapse cycle) of the bubble cloud increased with increasing pulse duration, peak rarefactional pressure, and PRF when the next pulse arrived after the collapse of the previous bubble cloud. When the PRF was too high such that the next pulse arrived before the collapse of the previous bubble cloud, only a portion of histotripsy pulses could effectively create and collapse the bubble cloud. The collapse cycle of the bubble cloud also increased with increasing gas concentration. These results may explain previous in vitro results on effects of pulse parameters on tissue erosion.

  7. Dynamics of dissolved gas in a cavitating fluid

    NASA Astrophysics Data System (ADS)

    Mastikhin, Igor V.; Newling, Benedict

    2008-12-01

    A strong acoustic field in a liquid separates the liquid and dissolved gases by the formation of bubbles (cavitation). Bubble growth and collapse is the result of active exchange of gas and vapor through the bubble walls with the surrounding liquid. This paper details a new approach to the study of cavitation, not as an evolution of discrete bubbles, but as the dynamics of molecules constituting both the bubbles and the fluid. We show, by direct, independent measurement of the liquid and the dissolved gas, that the motions of dissolved gas (freon-22, CHClF2 ) and liquid (water) can be quite different during acoustic cavitation and are strongly affected by filtration or previous cavitation of the solvent. Our observations suggest that bubbles can completely refresh their content within two acoustic cycles and that long-lived (˜minutes) microbubbles act as nucleation sites for cavitation. This technique is complementary to the traditional optical and acoustical techniques.

  8. Dependence of pulsed focused ultrasound induced thrombolysis on duty cycle and cavitation bubble size distribution.

    PubMed

    Xu, Shanshan; Zong, Yujin; Feng, Yi; Liu, Runna; Liu, Xiaodong; Hu, Yaxin; Han, Shimin; Wan, Mingxi

    2015-01-01

    In this study, we investigated the relationship between the efficiency of pulsed, focused ultrasound (FUS)-induced thrombolysis, the duty cycle (2.3%, 9%, and 18%) and the size distribution of cavitation bubbles. The efficiency of thrombolysis was evaluated through the degree of mechanical fragmentation, namely the number, mass, and size of clot debris particles. First, we found that the total number and mass of clot debris particles were highest when a duty cycle of 9% was used and that the mean diameter of clot debris particles was smallest. Second, we found that the size distribution of cavitation bubbles was mainly centered around the linear resonance radius (2.5μm) of the emission frequency (1.2MHz) of the FUS transducer when a 9% duty cycle was used, while the majority of cavitation bubbles became smaller or larger than the linear resonance radius when a 2.3% or 18% duty cycle was used. In addition, the inertial cavitation dose from the treatment performed at 9% duty cycle was much higher than the dose obtained with the other two duty cycles. The data presented here suggest that there is an optimal duty cycle at which the thrombolysis efficiency and cavitation activity are strongest. They further indicate that using a pulsed FUS may help control the size distribution of cavitation nuclei within an active size range, which we found to be near the linear resonance radius of the emission frequency of the FUS transducer.

  9. Optical observation of shock waves and cavitation bubbles in high intensity laser-induced shock processes

    SciTech Connect

    Marti-Lopez, L.; Ocana, R.; Porro, J. A.; Morales, M.; Ocana, J. L.

    2009-07-01

    We report an experimental study of the temporal and spatial dynamics of shock waves, cavitation bubbles, and sound waves generated in water during laser shock processing by single Nd:YAG laser pulses of nanosecond duration. A fast ICCD camera (2 ns gate time) was employed to record false schlieren photographs, schlieren photographs, and Mach-Zehnder interferograms of the zone surrounding the laser spot site on the target, an aluminum alloy sample. We recorded hemispherical shock fronts, cylindrical shock fronts, plane shock fronts, cavitation bubbles, and phase disturbance tracks.

  10. Probing Cell Deformability via Acoustically Actuated Bubbles.

    PubMed

    Xie, Yuliang; Nama, Nitesh; Li, Peng; Mao, Zhangming; Huang, Po-Hsun; Zhao, Chenglong; Costanzo, Francesco; Huang, Tony Jun

    2016-02-17

    An acoustically actuated, bubble-based technique is developed to investigate the deformability of cells suspended in microfluidic devices. A microsized bubble is generated by an optothermal effect near the targeted cells, which are suspended in a microfluidic chamber. Subsequently, acoustic actuation is employed to create localized acoustic streaming. In turn, the streaming flow results in hydrodynamic forces that deform the cells in situ. The deformability of the cells is indicative of their mechanical properties. The method in this study measures mechanical biomarkers from multiple cells in a single experiment, and it can be conveniently integrated with other bioanalysis and drug-screening platforms. Using this technique, the mean deformability of tens of HeLa, HEK, and HUVEC cells is measured to distinguish their mechanical properties. HeLa cells are deformed upon treatment with Cytochalasin. The technique also reveals the deformability of each subpopulation in a mixed, heterogeneous cell sample by the use of both fluorescent markers and mechanical biomarkers. The technique in this study, apart from being relevant to cell biology, will also enable biophysical cellular diagnosis. PMID:26715211

  11. Probing Cell Deformability via Acoustically Actuated Bubbles.

    PubMed

    Xie, Yuliang; Nama, Nitesh; Li, Peng; Mao, Zhangming; Huang, Po-Hsun; Zhao, Chenglong; Costanzo, Francesco; Huang, Tony Jun

    2016-02-17

    An acoustically actuated, bubble-based technique is developed to investigate the deformability of cells suspended in microfluidic devices. A microsized bubble is generated by an optothermal effect near the targeted cells, which are suspended in a microfluidic chamber. Subsequently, acoustic actuation is employed to create localized acoustic streaming. In turn, the streaming flow results in hydrodynamic forces that deform the cells in situ. The deformability of the cells is indicative of their mechanical properties. The method in this study measures mechanical biomarkers from multiple cells in a single experiment, and it can be conveniently integrated with other bioanalysis and drug-screening platforms. Using this technique, the mean deformability of tens of HeLa, HEK, and HUVEC cells is measured to distinguish their mechanical properties. HeLa cells are deformed upon treatment with Cytochalasin. The technique also reveals the deformability of each subpopulation in a mixed, heterogeneous cell sample by the use of both fluorescent markers and mechanical biomarkers. The technique in this study, apart from being relevant to cell biology, will also enable biophysical cellular diagnosis.

  12. Multifocal laser surgery: cutting enhancement by hydrodynamic interactions between cavitation bubbles.

    PubMed

    Toytman, I; Silbergleit, A; Simanovski, D; Palanker, D

    2010-10-01

    Transparent biological tissues can be precisely dissected with ultrafast lasers using optical breakdown in the tight focal zone. Typically, tissues are cut by sequential application of pulses, each of which produces a single cavitation bubble. We investigate the hydrodynamic interactions between simultaneous cavitation bubbles originating from multiple laser foci. Simultaneous expansion and collapse of cavitation bubbles can enhance the cutting efficiency, by increasing the resulting deformations in tissue, and the associated rupture zone. An analytical model of the flow induced by the bubbles is presented and experimentally verified. The threshold strain of the material rupture is measured in a model tissue. Using the computational model and the experimental value of the threshold strain one can compute the shape of the rupture zone in tissue resulting from application of multiple bubbles. With the threshold strain of 0.7 two simultaneous bubbles produce a continuous cut when applied at the distance 1.35 times greater than that required in sequential approach. Simultaneous focusing of the laser in multiple spots along the line of intended cut can extend this ratio to 1.7. Counterpropagating jets forming during collapse of two bubbles in materials with low viscosity can further extend the cutting zone-up to approximately a factor of 1.5.

  13. Numerical Model and Validation for Cryogenic High-Speed Cavitating Flow Based on Bubble Size Distribution Model in Consideration of Rigorous Heat Transfer around Bubble and Bubble Oscillation

    NASA Astrophysics Data System (ADS)

    Ito, Yutaka

    A bubble size distribution model has been developed by the author for a cryogenic high-speed cavitating flow of a turbo-pump in a liquid fuel rocket engine. In this model, bubble growth/decay and bubble advection are solved for each class of the bubble size, strictly mass, when there are various mass bubbles in the same calculation region. The above calculations are treated as Eulerian approach with respect to the bubble mass. The numerical results based on this model have agreed with the experimental results as a whole, however, some inconsistency still remained. It is suspected that the model of the bubble growth/decay causes the difference between the numerical and experimental results because heat transfer around the bubble was approximately computed by an analytical solution of unsteady heat transfer based on the elapsed-time from the bubble nucleation. In this paper, a new bubble size distribution model was redeveloped, in which the bubble growth/decay calculations employ a new method combining two rigorous methods, namely, a Rayleigh-Plesset equation for bubble oscillation, and a heat conduction equation in a thermal boundary layer around the bubble to evaluate mass rate of evaporation/condensation.

  14. A simple model of ultrasound propagation in a cavitating liquid. Part II: Primary Bjerknes force and bubble structures.

    PubMed

    Louisnard, O

    2012-01-01

    In a companion paper, a reduced model for propagation of acoustic waves in a cloud of inertial cavitation bubbles was proposed. The wave attenuation was calculated directly from the energy dissipated by a single bubble, the latter being estimated directly from the fully nonlinear radial dynamics. The use of this model in a mono-dimensional configuration has shown that the attenuation near the vibrating emitter was much higher than predictions obtained from linear theory, and that this strong attenuation creates a large traveling wave contribution, even for closed domain where standing waves are normally expected. In this paper, we show that, owing to the appearance of traveling waves, the primary Bjerknes force near the emitter becomes very large and tends to expel the bubbles up to a stagnation point. Two-dimensional axi-symmetric computations of the acoustic field created by a large area immersed sonotrode are also performed, and the paths of the bubbles in the resulting Bjerknes force field are sketched. Cone bubble structures are recovered and compare reasonably well to reported experimental results. The underlying mechanisms yielding such structures is examined, and it is found that the conical structure is generic and results from the appearance a sound velocity gradient along the transducer area. Finally, a more complex system, similar to an ultrasonic bath, in which the sound field results from the flexural vibrations of a thin plate, is also simulated. The calculated bubble paths reveal the appearance of other commonly observed structures in such configurations, such as streamers and flare structures. PMID:21764349

  15. Modeling of high-intensity focused ultrasound-induced lesions in the presence of cavitation bubbles

    PubMed

    Chavrier; Chapelon; Gelet; Cathignol

    2000-07-01

    The classical "Bio Heat Transfer Equation (BHTE)" model is adapted to take into account the effects of oscillating microbubbles that occur naturally in the tissue during high-intensity focused ultrasound (HIFU) treatment. First, the Gilmore-Akulichev model is used to quantify the acoustic pressure scattered by microbubbles submitted to HIFU. Because this scattered pressure is not monochromatic, the concept of harmonic attenuation is introduced and a global attenuation coefficient is estimated for bubble-filled tissues. The first results show that this global attenuation coefficient varies significantly with respect to several parameters such as the frequency and the density of microbubbles in the medium, but also with respect to the incident acoustic pressure which thus becomes a transcendental function. Under these conditions, a layer-by-layer modeling, in the direction of propagation, is proposed to calculate the ultrasonic beam. Finally, the BHTE is solved and the HIFU-induced lesions are estimated by the calculation of the thermal dose. Using this model, it can be observed first that, when the firing power increases, the lesion develops clearly in the direction of the transducer, with a shape agreeing with in vivo experimentation. Next, it is observed that the lesion can be significantly modified in size and position, if an interface (skin or inner wall) is simulated as a zone with multiple cavitation nuclei. With a firing power increase, it is also shown how a secondary lesion can appear at the interface and how, beyond a certain threshold, this lesion develops at the main lesion expense. Finally, a better in-depth homogeneity of lesions is observed when the acoustic frequency of HIFU is increased.

  16. Cavitation controlled acoustic probe for fabric spot cleaning and moisture monitoring

    DOEpatents

    Sheen, Shuh-Haw; Chien, Hual-Te; Raptis, Apostolos C.

    1997-01-01

    A method and apparatus are provided for monitoring a fabric. An acoustic probe generates acoustic waves relative to the fabric. An acoustic sensor, such as an accelerometer is coupled to the acoustic probe for generating a signal representative of cavitation activity in the fabric. The generated cavitation activity representative signal is processed to indicate moisture content of the fabric. A feature of the invention is a feedback control signal is generated responsive to the generated cavitation activity representative signal. The feedback control signal can be used to control the energy level of the generated acoustic waves and to control the application of a cleaning solution to the fabric.

  17. Studies on the tempo of bubble formation in recently cavitated vessels: a model to predict the pressure of air bubbles.

    PubMed

    Wang, Yujie; Pan, Ruihua; Tyree, Melvin T

    2015-06-01

    A cavitation event in a vessel replaces water with a mixture of water vapor and air. A quantitative theory is presented to argue that the tempo of filling of vessels with air has two phases: a fast process that extracts air from stem tissue adjacent to the cavitated vessels (less than 10 s) and a slow phase that extracts air from the atmosphere outside the stem (more than 10 h). A model was designed to estimate how water tension (T) near recently cavitated vessels causes bubbles in embolized vessels to expand or contract as T increases or decreases, respectively. The model also predicts that the hydraulic conductivity of a stem will increase as bubbles collapse. The pressure of air bubbles trapped in vessels of a stem can be predicted from the model based on fitting curves of hydraulic conductivity versus T. The model was validated using data from six stem segments each of Acer mono and the clonal hybrid Populus 84 K (Populus alba × Populus glandulosa). The model was fitted to results with root mean square error less than 3%. The model provided new insight into the study of embolism formation in stem tissue and helped quantify the bubble pressure immediately after the fast process referred to above.

  18. The effect of cavitation bubbles on the removal of juvenile barnacles.

    PubMed

    Guo, Shifeng; Khoo, Boo Cheong; Teo, Serena Lay Ming; Lee, Heow Pueh

    2013-09-01

    The effect of cavitation bubbles on the removal of juvenile barnacles was documented using high speed photography. Using spark generated bubbles, the interaction between barnacle and cavitation bubble was examined in detail. The liquid jet generated by the bubble collapse was observed to be directed towards barnacle at different impact intensities, which is related to the dimensionless distance H' (H'=H/Rm), where H is the distance between bubble formation point and the top of barnacle, and Rm is the maximum bubble radius. At lower values of H', higher speed liquid jet was produced; consequently a larger impact pressure was generated. In general, barnacles are more easily removed at a younger stage. In older barnacles, the liquid jet impact was only able to remove the barnacle shells, leaving the base plate attached to the surface. This study indicates that cavitation can be used to remove attached barnacles, and it would be more efficient if it is applied during early stages of fouling, before the formation of hard calcareous structures.

  19. Using acoustic cavitation to enhance chemotherapy of DOX liposomes: experiment in vitro and in vivo.

    PubMed

    Zhao, Ying-Zheng; Dai, Dan-Dan; Lu, Cui-Tao; Lv, Hai-Feng; Zhang, Yan; Li, Xing; Li, Wen-Feng; Wu, Yan; Jiang, Lei; Li, Xiao-Kun; Huang, Pin-Tong; Chen, Li-Juan; Lin, Min

    2012-09-01

    Experiments in vitro and in vivo were designed to investigate tumor growth inhibition of chemotherapeutics-loaded liposomes enhanced by acoustic cavitation. Doxorubicin-loaded liposomes (DOX liposomes) were used in experiments to investigate acoustic cavitation mediated effects on cell viability and chemotherapeutic function. The influence of lingering sensitive period after acoustic cavitation on tumor inhibition was also investigated. Animal experiment was carried out to verify the practicability of this technique in vivo. From experiment results, blank phospholipid-based microbubbles (PBM) combined with ultrasound (US) at intensity below 0.3 W/cm² could produce acoustic cavitation which maintained cell viability at high level. Compared with DOX solution, DOX liposomes combined with acoustic cavitation exerted effective tumor inhibition in vitro and in vivo. The lingering sensitive period after acoustic cavitation could also enhance the susceptibility of tumor to chemotherapeutic drugs. DOX liposomes could also exert certain tumor inhibition under preliminary acoustic cavitation. Acoustic cavitation could enhance the absorption efficiency of DOX liposomes, which could be used to reduce DOX adverse effect on normal organs in clinical chemotherapy.

  20. Molecular dynamics simulations of bubble formation and cavitation in liquid metals.

    SciTech Connect

    Insepov, Z.; Hassanein, A.; Bazhirov, T. T.; Norman, G. E.; Stegailov, V. V.; Mathematics and Computer Science; Inst. for High Energy Densities of Joint Inst. for High Temperatures of RAS

    2007-11-01

    Thermodynamics and kinetics of nano-scale bubble formation in liquid metals such as Li and Pb were studied by molecular dynamics (MD) simulations at pressures typical for magnetic and inertial fusion. Two different approaches to bubble formation were developed. In one method, radial densities, pressures, surface tensions, and work functions of the cavities in supercooled liquid lithium were calculated and compared with the surface tension experimental data. The critical radius of a stable cavity in liquid lithium was found for the first time. In the second method, the cavities were created in the highly stretched region of the liquid phase diagram; and then the stability boundary and the cavitation rates were calculated in liquid lead. The pressure dependences of cavitation frequencies were obtained over the temperature range 700-2700 K in liquid Pb. The results of MD calculations for cavitation rate were compared with estimates of classical nucleation theory (CNT).

  1. Evolution of bubble clouds induced by pulsed cavitational ultrasound therapy - histotripsy.

    PubMed

    Xu, Zhen; Raghavan, M; Hall, T L; Mycek, M-A; Fowlkes, J B

    2008-05-01

    Mechanical tissue fractionation can be achieved using successive, high-intensity ultrasound pulses in a process termed histotripsy. Histotripsy has many potential clinical applications where noninvasive tissue removal is desired. The primary mechanism for histotripsy is believed to be cavitation. Using fast-gated imaging, this paper studies the evolution of a cavitating bubble cloud induced by a histotripsy pulse (10 and 14 cycles) at peak negative pressures exceeding 21MPa. Bubble clouds are generated inside a gelatin phantom and at a tissue-water interface, representing two situations encountered clinically. In both environments, the imaging results show that the bubble clouds share the same evolutionary trend. The bubble cloud and individual bubbles in the cloud were generated by the first cycle of the pulse, grew with each cycle during the pulse, and continued to grow and collapsed several hundred microseconds after the pulse. For example, the bubbles started under 10 microm, grew to 50 microm during the pulse, and continued to grow 100 microm after the pulse. The results also suggest that the bubble clouds generated in the two environments differ in growth and collapse duration, void fraction, shape, and size. This study furthers our understanding of the dynamics of bubble clouds induced by histotripsy.

  2. Interaction of lithotripter shockwaves with single inertial cavitation bubbles.

    PubMed

    Klaseboer, Evert; Fong, Siew Wan; Turangan, Cary K; Khoo, Boo Cheong; Szeri, Andrew J; Calvisi, Michael L; Sankin, Georgy N; Zhong, Pei

    2007-01-01

    The dynamic interaction of a shockwave (modelled as a pressure pulse) with an initially spherically oscillating bubble is investigated. Upon the shockwave impact, the bubble deforms non-spherically and the flow field surrounding the bubble is determined with potential flow theory using the boundary-element method (BEM). The primary advantage of this method is its computational efficiency. The simulation process is repeated until the two opposite sides of the bubble surface collide with each other (i.e. the formation of a jet along the shockwave propagation direction). The collapse time of the bubble, its shape and the velocity of the jet are calculated. Moreover, the impact pressure is estimated based on water-hammer pressure theory. The Kelvin impulse, kinetic energy and bubble displacement (all at the moment of jet impact) are also determined. Overall, the simulated results compare favourably with experimental observations of lithotripter shockwave interaction with single bubbles (using laser-induced bubbles at various oscillation stages). The simulations confirm the experimental observation that the most intense collapse, with the highest jet velocity and impact pressure, occurs for bubbles with intermediate size during the contraction phase when the collapse time of the bubble is approximately equal to the compressive pulse duration of the shock wave. Under this condition, the maximum amount of energy of the incident shockwave is transferred to the collapsing bubble. Further, the effect of the bubble contents (ideal gas with different initial pressures) and the initial conditions of the bubble (initially oscillating vs. non-oscillating) on the dynamics of the shockwave-bubble interaction are discussed.

  3. Micro-bubble emission boiling with the cavitation bubble blow pit

    PubMed Central

    Inada, Shigeaki; Shinagawa, Kazuaki; Illias, Suhaimi Bin; Sumiya, Hiroyuki; Jalaludin, Helmisyah A.

    2016-01-01

    The miniaturization boiling (micro-bubble emission boiling [MEB]) phenomenon, with a high heat removal capacity that contributes considerably to the cooling of the divertor of the nuclear fusion reactor, was discovered in the early 1980s. Extensive research on MEB has been performed since its discovery. However, the progress of the application has been delayed because the generation mechanism of MEB remains unclear. Reasons for this lack of clarity include the complexity of the phenomenon itself and the high-speed phase change phenomenon in which boiling and condensation are rapidly generated. In addition, a more advanced thermal technique is required to realize the MEB phenomenon at the laboratory scale. To the authors’ knowledge, few studies have discussed the rush mechanism of subcooled liquid to the heating surface, which is critical to elucidating the mechanism behind MEB. This study used photographic images to verify that the cavitation phenomenon spreads to the inside of the superheated liquid on the heating surface and thus clarify the mechanism of MEB. PMID:27628271

  4. Micro-bubble emission boiling with the cavitation bubble blow pit.

    PubMed

    Inada, Shigeaki; Shinagawa, Kazuaki; Illias, Suhaimi Bin; Sumiya, Hiroyuki; Jalaludin, Helmisyah A

    2016-01-01

    The miniaturization boiling (micro-bubble emission boiling [MEB]) phenomenon, with a high heat removal capacity that contributes considerably to the cooling of the divertor of the nuclear fusion reactor, was discovered in the early 1980s. Extensive research on MEB has been performed since its discovery. However, the progress of the application has been delayed because the generation mechanism of MEB remains unclear. Reasons for this lack of clarity include the complexity of the phenomenon itself and the high-speed phase change phenomenon in which boiling and condensation are rapidly generated. In addition, a more advanced thermal technique is required to realize the MEB phenomenon at the laboratory scale. To the authors' knowledge, few studies have discussed the rush mechanism of subcooled liquid to the heating surface, which is critical to elucidating the mechanism behind MEB. This study used photographic images to verify that the cavitation phenomenon spreads to the inside of the superheated liquid on the heating surface and thus clarify the mechanism of MEB. PMID:27628271

  5. Micro-bubble emission boiling with the cavitation bubble blow pit

    NASA Astrophysics Data System (ADS)

    Inada, Shigeaki; Shinagawa, Kazuaki; Illias, Suhaimi Bin; Sumiya, Hiroyuki; Jalaludin, Helmisyah A.

    2016-09-01

    The miniaturization boiling (micro-bubble emission boiling [MEB]) phenomenon, with a high heat removal capacity that contributes considerably to the cooling of the divertor of the nuclear fusion reactor, was discovered in the early 1980s. Extensive research on MEB has been performed since its discovery. However, the progress of the application has been delayed because the generation mechanism of MEB remains unclear. Reasons for this lack of clarity include the complexity of the phenomenon itself and the high-speed phase change phenomenon in which boiling and condensation are rapidly generated. In addition, a more advanced thermal technique is required to realize the MEB phenomenon at the laboratory scale. To the authors’ knowledge, few studies have discussed the rush mechanism of subcooled liquid to the heating surface, which is critical to elucidating the mechanism behind MEB. This study used photographic images to verify that the cavitation phenomenon spreads to the inside of the superheated liquid on the heating surface and thus clarify the mechanism of MEB.

  6. Micro-bubble emission boiling with the cavitation bubble blow pit.

    PubMed

    Inada, Shigeaki; Shinagawa, Kazuaki; Illias, Suhaimi Bin; Sumiya, Hiroyuki; Jalaludin, Helmisyah A

    2016-01-01

    The miniaturization boiling (micro-bubble emission boiling [MEB]) phenomenon, with a high heat removal capacity that contributes considerably to the cooling of the divertor of the nuclear fusion reactor, was discovered in the early 1980s. Extensive research on MEB has been performed since its discovery. However, the progress of the application has been delayed because the generation mechanism of MEB remains unclear. Reasons for this lack of clarity include the complexity of the phenomenon itself and the high-speed phase change phenomenon in which boiling and condensation are rapidly generated. In addition, a more advanced thermal technique is required to realize the MEB phenomenon at the laboratory scale. To the authors' knowledge, few studies have discussed the rush mechanism of subcooled liquid to the heating surface, which is critical to elucidating the mechanism behind MEB. This study used photographic images to verify that the cavitation phenomenon spreads to the inside of the superheated liquid on the heating surface and thus clarify the mechanism of MEB.

  7. Study on the spatial distribution of the liquid temperature near a cavitation bubble wall.

    PubMed

    Shen, Yang; Yasui, Kyuichi; Sun, Zhicheng; Mei, Bin; You, Meiyan; Zhu, Tong

    2016-03-01

    A simple new model of the spatial distribution of the liquid temperature near a cavitation bubble wall (Tli) is employed to numerically calculate Tli. The result shows that Tli is almost same with the ambient liquid temperature (T0) during the bubble oscillations except at strong collapse. At strong collapse, Tli can increase to about 1510 K, the same order of magnitude with that of the maximum temperature inside the bubble, which means that the chemical reactions occur not only in gas-phase inside the collapsing bubble but also in liquid-phase just outside the collapsing bubble. Four factors (ultrasonic vibration amplitude, ultrasonic frequency, the surface tension and the viscosity) are considered to study their effects for the thin liquid layer. The results show that for the thin layer, the thickness and the temperature increase as the ultrasonic vibration amplitude rise; conversely, the thickness and the temperature decrease with the increase of the ultrasonic frequency, the surface tension or the viscosity.

  8. Acoustic cavitation-based monitoring of the reversibility and permeability of ultrasound-induced blood-brain barrier opening

    NASA Astrophysics Data System (ADS)

    Sun, Tao; Samiotaki, Gesthimani; Wang, Shutao; Acosta, Camilo; Chen, Cherry C.; Konofagou, Elisa E.

    2015-12-01

    Cavitation events seeded by microbubbles have been previously reported to be associated with MR- or fluorescent-contrast enhancement after focused ultrasound (FUS)-induced blood-brain barrier (BBB) opening. However, it is still unknown whether bubble activity can be correlated with the reversibility (the duration of opening and the likelihood of safe reinstatement) and the permeability of opened BBB, which is critical for the clinical translation of using passive cavitation detection to monitor, predict and control the opening. In this study, the dependence of acoustic cavitation on the BBB opening duration, permeability coefficient and histological damage occurrence were thus investigated. Transcranial pulsed FUS at 1.5 MHz in the presence of systemically circulating microbubbles was applied in the mouse hippocampi (n  =  60). The stable and inertial cavitation activities were monitored during sonication. Contrast-enhanced MRI was performed immediately after sonication and every 24 h up to 6 d thereafter, to assess BBB opening, brain tissue permeability and potential edema. Histological evaluations were used to assess the occurrence of neurovascular damages. It was found that stable cavitation was well correlated with: (1) the duration of the BBB opening (r2  =  0.77) (2) the permeability of the opened BBB (r2  =  0.82) (3) the likelihood of safe opening (P  <  0.05, safe opening compared to cases of damage; P  <  0.0001, no opening compared to safe opening). The inertial cavitation dose was correlated with the resulting BBB permeability (r2  =  0.72). Stable cavitation was found to be more reliable than inertial cavitation at assessing the BBB opening within the pressure range used in this study. This study demonstrates that the stable cavitation response during BBB opening holds promise for predicting and controlling the restoration and pharmacokinetics of FUS-opened BBB. The stable cavitation response therefore

  9. Acoustic cavitation-based monitoring of the reversibility and permeability of ultrasound-induced blood-brain barrier opening.

    PubMed

    Sun, Tao; Samiotaki, Gesthimani; Wang, Shutao; Acosta, Camilo; Chen, Cherry C; Konofagou, Elisa E

    2015-12-01

    Cavitation events seeded by microbubbles have been previously reported to be associated with MR- or fluorescent-contrast enhancement after focused ultrasound (FUS)-induced blood-brain barrier (BBB) opening. However, it is still unknown whether bubble activity can be correlated with the reversibility (the duration of opening and the likelihood of safe reinstatement) and the permeability of opened BBB, which is critical for the clinical translation of using passive cavitation detection to monitor, predict and control the opening. In this study, the dependence of acoustic cavitation on the BBB opening duration, permeability coefficient and histological damage occurrence were thus investigated. Transcranial pulsed FUS at 1.5 MHz in the presence of systemically circulating microbubbles was applied in the mouse hippocampi (n  =  60). The stable and inertial cavitation activities were monitored during sonication. Contrast-enhanced MRI was performed immediately after sonication and every 24 h up to 6 d thereafter, to assess BBB opening, brain tissue permeability and potential edema. Histological evaluations were used to assess the occurrence of neurovascular damages. It was found that stable cavitation was well correlated with: (1) the duration of the BBB opening (r(2)  =  0.77); (2) the permeability of the opened BBB (r(2)  =  0.82); (3) the likelihood of safe opening (P  <  0.05, safe opening compared to cases of damage; P  <  0.0001, no opening compared to safe opening). The inertial cavitation dose was correlated with the resulting BBB permeability (r(2)  =  0.72). Stable cavitation was found to be more reliable than inertial cavitation at assessing the BBB opening within the pressure range used in this study. This study demonstrates that the stable cavitation response during BBB opening holds promise for predicting and controlling the restoration and pharmacokinetics of FUS-opened BBB. The stable cavitation response

  10. Periodic shock-emission from acoustically driven cavitation clouds: a source of the subharmonic signal.

    PubMed

    Johnston, Keith; Tapia-Siles, Cecilia; Gerold, Bjoern; Postema, Michiel; Cochran, Sandy; Cuschieri, Alfred; Prentice, Paul

    2014-12-01

    Single clouds of cavitation bubbles, driven by 254kHz focused ultrasound at pressure amplitudes in the range of 0.48-1.22MPa, have been observed via high-speed shadowgraphic imaging at 1×10(6) frames per second. Clouds underwent repetitive growth, oscillation and collapse (GOC) cycles, with shock-waves emitted periodically at the instant of collapse during each cycle. The frequency of cloud collapse, and coincident shock-emission, was primarily dependent on the intensity of the focused ultrasound driving the activity. The lowest peak-to-peak pressure amplitude of 0.48MPa generated shock-waves with an average period of 7.9±0.5μs, corresponding to a frequency of f0/2, half-harmonic to the fundamental driving. Increasing the intensity gave rise to GOC cycles and shock-emission periods of 11.8±0.3, 15.8±0.3, 19.8±0.2μs, at pressure amplitudes of 0.64, 0.92 and 1.22MPa, corresponding to the higher-order subharmonics of f0/3, f0/4 and f0/5, respectively. Parallel passive acoustic detection, filtered for the fundamental driving, revealed features that correlated temporally to the shock-emissions observed via high-speed imaging, p(two-tailed) < 0.01 (r=0.996, taken over all data). Subtracting the isolated acoustic shock profiles from the raw signal collected from the detector, demonstrated the removal of subharmonic spectral peaks, in the frequency domain. The larger cavitation clouds (>200μm diameter, at maximum inflation), that developed under insonations of peak-to-peak pressure amplitudes >1.0MPa, emitted shock-waves with two or more fronts suggesting non-uniform collapse of the cloud. The observations indicate that periodic shock-emissions from acoustically driven cavitation clouds provide a source for the cavitation subharmonic signal, and that shock structure may be used to study intra-cloud dynamics at sub-microsecond timescales.

  11. Control of cavitation activity by different shockwave pulsing regimes.

    PubMed

    Huber, P; Debus, J; Jöchle, K; Simiantonakis, I; Jenne, J; Rastert, R; Spoo, J; Lorenz, W J; Wannenmacher, M

    1999-06-01

    The aim of the study was to control the number of inertial cavitation bubbles in the focal area of an electromagnetic lithotripter in water independently of peak intensity, averaged intensity or pressure waveform. To achieve this, the shockwave pulses were applied in double pulse sequences, which were administered at a fixed pulse repetition frequency (PRF) of 0.33 Hz. The two pulses of a double pulse were separated by a variable short pulse separation time (PST) ranging from 200 micros to 1500 ms. The number and size of the cavitation bubbles were monitored by scattered laser light and stroboscopic photographs. We found that the number of inertial cavitation bubbles as a measure of cavitation dose was substantially influenced by variation of the PST, while the pressure pulse waveform, averaged acoustic intensity and bubble size were kept constant. The second pulse of each double pulse generated more cavitation bubbles than the first. At 14 kV capacitor voltage, the total number of cavitation bubbles generated by the double pulses increased with shorter PST down to approximately 400 micros, the cavitation lifespan. The results can be explained by cavitation nuclei generated by the violently imploding inertial cavitation bubbles. This method of pulse administration and cavitation monitoring could be useful to establish a cavitation dose-effect relationship independently of other acoustic parameters.

  12. Dynamic Nucleation of Ice Induced by a Single Stable Cavitation Bubble

    NASA Technical Reports Server (NTRS)

    Ohsaka, Kenichi; Trinh, Eugene H.

    1997-01-01

    Dynamic nucleation of ice induced by caviation bubble in undercooled water is observed using an acoustic levitation technique. The observation indicates that a high pressure pulse associated with a collapsing bubble is indeed responsible for the nucleation of a high pressure phase of ice.

  13. Spatial-temporal ultrasound imaging of residual cavitation bubbles around a fluid-tissue interface in histotripsy.

    PubMed

    Hu, Hong; Xu, Shanshan; Yuan, Yuan; Liu, Runna; Wang, Supin; Wan, Mingxi

    2015-05-01

    Cavitation is considered as the primary mechanism of soft tissue fragmentation (histotripsy) by pulsed high-intensity focused ultrasound. The residual cavitation bubbles have a dual influence on the histotripsy pulses: these serve as nuclei for easy generation of new cavitation, and act as strong scatterers causing energy "shadowing." To monitor the residual cavitation bubbles in histotripsy, an ultrafast active cavitation imaging method with relatively high signal-to-noise ratio and good spatial-temporal resolution was proposed in this paper, which combined plane wave transmission, minimum variance beamforming, and coherence factor weighting. The spatial-temporal evolutions of residual cavitation bubbles around a fluid-tissue interface in histotripsy under pulse duration (PD) of 10-40 μs and pulse repetition frequency (PRF) of 0.67-2 kHz were monitored by this method. The integrated bubble area curves inside the tissue interface were acquired from the bubble image sequence, and the formation process of histotripsy damage was estimated. It was observed that the histotripsy efficiency decreased with both longer PDs and higher PRFs. A direct relationship with a coefficient of 1.0365 between histotripsy lesion area and inner residual bubble area was found. These results can assist in monitoring and optimization of the histotripsy treatment further.

  14. Spatial-temporal ultrasound imaging of residual cavitation bubbles around a fluid-tissue interface in histotripsy.

    PubMed

    Hu, Hong; Xu, Shanshan; Yuan, Yuan; Liu, Runna; Wang, Supin; Wan, Mingxi

    2015-05-01

    Cavitation is considered as the primary mechanism of soft tissue fragmentation (histotripsy) by pulsed high-intensity focused ultrasound. The residual cavitation bubbles have a dual influence on the histotripsy pulses: these serve as nuclei for easy generation of new cavitation, and act as strong scatterers causing energy "shadowing." To monitor the residual cavitation bubbles in histotripsy, an ultrafast active cavitation imaging method with relatively high signal-to-noise ratio and good spatial-temporal resolution was proposed in this paper, which combined plane wave transmission, minimum variance beamforming, and coherence factor weighting. The spatial-temporal evolutions of residual cavitation bubbles around a fluid-tissue interface in histotripsy under pulse duration (PD) of 10-40 μs and pulse repetition frequency (PRF) of 0.67-2 kHz were monitored by this method. The integrated bubble area curves inside the tissue interface were acquired from the bubble image sequence, and the formation process of histotripsy damage was estimated. It was observed that the histotripsy efficiency decreased with both longer PDs and higher PRFs. A direct relationship with a coefficient of 1.0365 between histotripsy lesion area and inner residual bubble area was found. These results can assist in monitoring and optimization of the histotripsy treatment further. PMID:25994689

  15. Correlation between microbubble-induced acoustic cavitation and hemolysis in vitro

    NASA Astrophysics Data System (ADS)

    Zhang, Chun-Bing; Liu, Zheng; Guo, Xia-Sheng; Zhang, Dong

    2011-02-01

    Microbubbles promise to enhance the efficiency of ultrasound-mediated drug delivery and gene therapy by taking advantage of artificial cavitation nuclei. The purpose of this study is to examine the ultrasound-induced hemolysis in the application of drug delivery in the presence of microbubbles. To achieve this goal, human red blood cells mixed with microbubbles were exposed to 1-MHz pulsed ultrasound. The hemolysis level was measured by a flow cytometry, and the cavitation dose was detected by a passive cavitation detecting system. The results demonstrate that larger cavitation dose would be generated with the increase of acoustic pressure, which might give rise to the enhancement of hemolysis. Besides the experimental observations, the acoustic pressure dependence of the radial oscillation of microbubble was theoretically estimated. The comparison between the experimental and calculation results indicates that the hemolysis should be highly correlated to the acoustic cavitation.

  16. Cavitation bubbles induced by Erbium lasers: implications for dentistry

    NASA Astrophysics Data System (ADS)

    Verleng, Marja; Verdaasdonk, Rudolf; van der Veen, Albert; Lemberg, Vladimir; Boutoussov, Dmitri

    2014-02-01

    With new fiber systems available for 3 μm, Erbium lasers become more interesting for precise tissue ablation in a water environment enabling new application in e.g. dentistry. The dynamics of explosive bubble formation was investigated at 2.78 μm (Er,Cr;YSGG) and 2.94 μm (Er:YAG), in relation to energy (10-50 mJ), pulse length (20-150 μs) and fiber tip shape (flat or taper). The dynamics of exploding and imploding vapor bubbles were captured with high speed imaging (10 - 300 μs range). Increasing the pulse length and energy, the vapor bubble became more elongated with an opaque surface for flat tip fibers. Tapered fibers produced spherical vapor bubbles with an optically transparent surface expected to be more forceful for creating mechanical effects in both hard and soft tissues. There was no significant difference between bubbles formed at 2.78 μm (Er,Cr;YSGG) and 2.94 μm (Er:YAG).

  17. Recent theories of cavitation damage including non-symmetrical bubble collapse effects

    NASA Technical Reports Server (NTRS)

    Hammitt, F. G.

    1974-01-01

    Theories of cavitation damage mechanisms are discussed. Photographic evidence has shown that the actual collapse of bubbles near a symmetry-destroying feature such as a nearby wall results in a toroidal-like collapse, with the final generation of a liquid microjet oriented toward the wall. Numerical analyses indicate that the shock wave intensity emitted during collapse is not likely to be strong enough to be damaging to most materials. It has been determined that actual damage is usually a result of a combination of impact effect of the microjet and the shock wave pressures generated by bubble rebounds.

  18. Cavitation in medicine.

    PubMed

    Brennen, Christopher Earls

    2015-10-01

    We generally think of bubbles as benign and harmless and yet they can manifest the most remarkable range of physical effects. Some of those effects are the stuff of our everyday experience as in the tinkling of a brook or the sounds of breaking waves at the beach. But even these mundane effects are examples of the ability of bubbles to gather, focus and radiate energy (acoustic energy in the above examples). In other contexts that focusing of energy can lead to serious technological problems as when cavitation bubbles eat great holes through ships' propeller blades or cause a threat to the integrity of the spillways at the Hoover Dam. In liquid-propelled rocket engines, bubbles pose a danger to the stability of the propulsion system, and in artificial heart valves they can cause serious damage to the red blood cells. In perhaps the most extraordinary example of energy focusing, collapsing cavitation bubbles can emit not only sound, but also light with black body radiation temperatures equal to that of the sun (Brennen 1995 Cavitation and bubble dynamics). But, harnessed carefully, this almost unique ability to focus energy can also be put to remarkably constructive use. Cavitation bubbles are now used in a remarkable range of surgical and medical procedures, for example to emulsify tissue (most commonly in cataract surgery or in lithotripsy procedures for the reduction of kidney and gall stones) or to manipulate the DNA in individual cells. By creating cavitation bubbles non-invasively thereby depositing and focusing energy non-intrusively, one can generate minute incisions or target cancer cells. This paper will begin by briefly reviewing the history of cavitation phenomena and will end with a vision of the new horizons for the amazing cavitation bubble. PMID:26442145

  19. Cavitation in medicine

    PubMed Central

    Brennen, Christopher Earls

    2015-01-01

    We generally think of bubbles as benign and harmless and yet they can manifest the most remarkable range of physical effects. Some of those effects are the stuff of our everyday experience as in the tinkling of a brook or the sounds of breaking waves at the beach. But even these mundane effects are examples of the ability of bubbles to gather, focus and radiate energy (acoustic energy in the above examples). In other contexts that focusing of energy can lead to serious technological problems as when cavitation bubbles eat great holes through ships' propeller blades or cause a threat to the integrity of the spillways at the Hoover Dam. In liquid-propelled rocket engines, bubbles pose a danger to the stability of the propulsion system, and in artificial heart valves they can cause serious damage to the red blood cells. In perhaps the most extraordinary example of energy focusing, collapsing cavitation bubbles can emit not only sound, but also light with black body radiation temperatures equal to that of the sun (Brennen 1995 Cavitation and bubble dynamics). But, harnessed carefully, this almost unique ability to focus energy can also be put to remarkably constructive use. Cavitation bubbles are now used in a remarkable range of surgical and medical procedures, for example to emulsify tissue (most commonly in cataract surgery or in lithotripsy procedures for the reduction of kidney and gall stones) or to manipulate the DNA in individual cells. By creating cavitation bubbles non-invasively thereby depositing and focusing energy non-intrusively, one can generate minute incisions or target cancer cells. This paper will begin by briefly reviewing the history of cavitation phenomena and will end with a vision of the new horizons for the amazing cavitation bubble. PMID:26442145

  20. Analytical and experimental study of the acoustics and the flow field characteristics of cavitating self-resonating water jets

    SciTech Connect

    Chahine, G.L.; Genoux, P.F.; Johnson, V.E. Jr.; Frederick, G.S.

    1984-09-01

    Waterjet nozzles (STRATOJETS) have been developed which achieve passive structuring of cavitating submerged jets into discrete ring vortices, and which possess cavitation incipient numbers six times higher than obtained with conventional cavitating jet nozzles. In this study we developed analytical and numerical techniques and conducted experimental work to gain an understanding of the basic phenomena involved. The achievements are: (1) a thorough analysis of the acoustic dynamics of the feed pipe to the nozzle; (2) a theory for bubble ring growth and collapse; (3) a numerical model for jet simulation; (4) an experimental observation and analysis of candidate second-generation low-sigma STRATOJETS. From this study we can conclude that intensification of bubble ring collapse and design of highly resonant feed tubes can lead to improved drilling rates. The models here described are excellent tools to analyze the various parameters needed for STRATOJET optimizations. Further analysis is needed to introduce such important factors as viscosity, nozzle-jet interaction, and ring-target interaction, and to develop the jet simulation model to describe the important fine details of the flow field at the nozzle exit.

  1. Thresholds for cavitation produced in water by pulsed ultrasound.

    PubMed

    Atchley, A A; Frizzell, L A; Apfel, R E; Holland, C K; Madanshetty, S; Roy, R A

    1988-09-01

    The threshold for transient cavitation produced in water by pulsed ultrasound was measured as a function of pulse duration and pulse repetition frequency at both 0.98 and 2.30 MHz. The cavitation events were detected with a passive acoustic technique which relies upon the scattering of the irradiation field by the bubble clouds associated with the events. The results indicate that the threshold is independent of pulse duration and acoustic frequency for pulses longer than approximately 10 acoustic cycles. The threshold increases for shorter pulses. The cavitation events are likely to be associated with bubble clouds rather than single bubbles.

  2. Orbital motions of bubbles in an acoustic field

    NASA Astrophysics Data System (ADS)

    Shirota, Minori; Yamashita, Ko; Inamura, Takao

    2012-09-01

    This experimental study aims to clarify the mechanism of orbital motion of two oscillating bubbles in an acoustic field. Trajectory of the orbital motion on the wall of a spherical levitator was observed using a high-speed video camera. Because of a good repeatability in volume oscillation of bubbles, we were also able to observe the radial motion driven at 24 kHz by stroboscopic like imaging technique. The orbital motions of bubbles raging from 0.13 to 0.18 mm were examined with different forcing amplitude and in different viscous oils. As a result, we found that pairs of bubbles revolve along an elliptic orbit around the center of mass of the bubbles. We also found that the two bubbles perform anti-phase radial oscillation. Although this radial oscillation should result in a repulsive secondary Bjerknes force, the bubbles kept a constant separate distance of about 1 mm, which indicates the existence of centripetal primary Bjerknes force.

  3. Variations of bubble cavitation and temperature elevation during lesion formation by high-intensity focused ultrasound.

    PubMed

    Zhou, Yufeng; Gao, Xiaobin Wilson

    2013-08-01

    High-intensity focused ultrasound (HIFU) is emerging as an effective therapeutic modality in both thermal ablations for solid tumor/cancer and soft-tissue fragmentation. Mechanical and thermal effects, which play an important role in the HIFU treatment simultaneously, are dependent on the operating parameters and may vary with the progress of therapy. Mechanical erosion in the shape of a "squid," a "dumbbell" lesion with both mechanical and thermal lesions, or a "tadpole" lesion with mechanical erosion at the center and thermal necrosis on the boundary in the transparent gel phantom could be produced correspondingly with the pulse duration of 5-30 ms, which is much longer than histotripsy burst but shorter than the time for tissue boiling, and pulse repetition frequency (PRF) of 0.2-5 Hz. Meanwhile, variations of bubble cavitation (both inertial and stable cavitation) and temperature elevation in the focal region (i.e., z = -2.5, 0, and 2.5 mm) were measured by passive cavitation detection (PCD) and thermocouples during the therapeutic procedure, respectively. Stable cavitation increased with the pulse duration, PRF, and the number of pulses delivered. However, inertial cavitation was found to increase initially and then decrease with long pulse duration and high PRF. Temperature in the pre-focal region is always higher than those at the focal and post-focal position in all tests. Great variations of PCD signals and temperature elevation are due to the generation and persistence of large bubble, which is resistant to collapse and occurs with the increase of pulse duration and PRF. Similar lesion pattern and variations were also observed in ex vivo porcine kidneys. Hyperechoes in the B-mode ultrasound image were comparable to the shape and size of lesions in the dissected tissue. Thermal lesion volume increased with the increase of pulse duration and PRF, but mechanical erosion reached its maximum volume with the pulse duration of 20 ms and PRF of 1

  4. Wavelet-transform-based active imaging of cavitation bubbles in tissues induced by high intensity focused ultrasound.

    PubMed

    Liu, Runna; Xu, Shanshan; Hu, Hong; Huo, Rui; Wang, Supin; Wan, Mingxi

    2016-08-01

    Cavitation detection and imaging are essential for monitoring high-intensity focused ultrasound (HIFU) therapies. In this paper, an active cavitation imaging method based on wavelet transform is proposed to enhance the contrast between the cavitation bubbles and surrounding tissues. The Yang-Church model, which is a combination of the Keller-Miksis equation with the Kelvin-Voigt equation for the pulsations of gas bubbles in simple linear viscoelastic solids, is utilized to construct the bubble wavelet. Experiments with porcine muscles demonstrate that image quality is associated with the initial radius of the bubble wavelet and the scale. Moreover, the Yang-Church model achieves a somewhat better performance compared with the Rayleigh-Plesset-Noltingk-Neppiras-Poritsky model. Furthermore, the pulse inversion (PI) technique is combined with bubble wavelet transform to achieve further improvement. The cavitation-to-tissue ratio (CTR) of the best tissue bubble wavelet transform (TBWT) mode image is improved by 5.1 dB compared with that of the B-mode image, while the CTR of the best PI-based TBWT mode image is improved by 7.9 dB compared with that of the PI-based B-mode image. This work will be useful for better monitoring of cavitation in HIFU-induced therapies.

  5. Wavelet-transform-based active imaging of cavitation bubbles in tissues induced by high intensity focused ultrasound.

    PubMed

    Liu, Runna; Xu, Shanshan; Hu, Hong; Huo, Rui; Wang, Supin; Wan, Mingxi

    2016-08-01

    Cavitation detection and imaging are essential for monitoring high-intensity focused ultrasound (HIFU) therapies. In this paper, an active cavitation imaging method based on wavelet transform is proposed to enhance the contrast between the cavitation bubbles and surrounding tissues. The Yang-Church model, which is a combination of the Keller-Miksis equation with the Kelvin-Voigt equation for the pulsations of gas bubbles in simple linear viscoelastic solids, is utilized to construct the bubble wavelet. Experiments with porcine muscles demonstrate that image quality is associated with the initial radius of the bubble wavelet and the scale. Moreover, the Yang-Church model achieves a somewhat better performance compared with the Rayleigh-Plesset-Noltingk-Neppiras-Poritsky model. Furthermore, the pulse inversion (PI) technique is combined with bubble wavelet transform to achieve further improvement. The cavitation-to-tissue ratio (CTR) of the best tissue bubble wavelet transform (TBWT) mode image is improved by 5.1 dB compared with that of the B-mode image, while the CTR of the best PI-based TBWT mode image is improved by 7.9 dB compared with that of the PI-based B-mode image. This work will be useful for better monitoring of cavitation in HIFU-induced therapies. PMID:27586712

  6. Numerical simulations of the aspherical collapse of laser and acoustically generated bubbles.

    PubMed

    Tsiglifis, Kostas; Pelekasis, Nikos A

    2007-04-01

    The details of nonlinear axisymmetric oscillations and collapse of bubbles subject to large internal or external pressure disturbances, are studied via a boundary integral method. Weak viscous effects on the liquid side are accounted for by integrating the equations of motion across the boundary layer that is formed adjacent to the interface. Simulations of single-cavitation bubble luminescence (SCBL) and single-bubble sonoluminescence (SBSL) are performed under conditions similar to reported experimental observations, aiming at capturing the details of bubble collapse. It is shown that any small initial deviation from sphericity, modeled through a small initial elongation along the axis of symmetry, may result in the formation and impact of two counter-propagating jets during collapse of the bubble, provided the amplitude of the initial disturbance is large enough and the viscosity of the surrounding fluid is small enough. Comparison between simulations and experimental observations show that this is the case for bubbles induced via a nano-second laser pulse (SCBL) during a luminescence event. In a similar fashion, simulations show that loss of sphericity accompanied with jet formation and impact during collapse is also possible with acoustically trapped bubbles in a standing pressure wave (SBSL), due to the many afterbounces of the bubble during its collapse phase. In both cases jet impact occurs as a result of P(2) growth in the form of an afterbounce instability. When the sound amplitude is decreased or liquid viscosity is increased the intensity of the afterbounce is decreased and jet impact is suppressed. When the sound amplitude is increased jet formation is superceded by Rayleigh-Taylor instability. In the same context stable luminescence is quenched in experimental observations. In both SCBL and SBSL simulations the severity of jet impact during collapse is quite large, and its local nature quite distinct. This attests to the fact that it is an energy

  7. Bubble-induced sheet cavitation inception on an isolated roughness element

    NASA Astrophysics Data System (ADS)

    van Rijsbergen, Martijn; Slot, Jesse

    2015-12-01

    The nucleation process on an isolated roughness element, located at the point of minimum pressure of a NACA 0015 hydrofoil was studied experimentally and computationally. The objective of this study was to investigate the working mechanism of bubble-induced sheet cavitation inception. High-speed micro-scale observations show the generation of a streak of cavitation—attached to the roughness element—in the wake of the bubble. Below its critical diameter, the bubble can detach from the streak cavity and travel on while the streak cavity remains. The solutions of a Rayleigh-Plesset equation along a streamline extracted from a RANS calculation show strong similarities with the experimental observations, but a factor 5 to 10 higher frame rate is needed to validate the calculations.

  8. Influence of acoustic pressure and bubble sizes on the coalescence of two contacting bubbles in an acoustic field.

    PubMed

    Jiao, Junjie; He, Yong; Yasui, Kyuichi; Kentish, Sandra E; Ashokkumar, Muthupandian; Manasseh, Richard; Lee, Judy

    2015-01-01

    In this study, the coalescence time between two contacting sub-resonance size bubbles was measured experimentally under an acoustic pressure ranging from 10kPa to 120kPa, driven at a frequency of 22.4kHz. The coalescence time obtained under sonication was much longer compared to that calculated by the film drainage theory for a free bubble surface without surfactants. It was found that under the influence of an acoustic field, the coalescence time could be probabilistic in nature, exhibiting upper and lower limits of coalescence times which are prolonged when both the maximum surface approach velocity and secondary Bjerknes force increases. The size of the two contacting bubbles is also important. For a given acoustic pressure, bubbles having a larger average size and size difference were observed to exhibit longer coalescence times. This could be caused by the phase difference between the volume oscillations of the two bubbles, which in turn affects the minimum film thickness reached between the bubbles and the film drainage time. These results will have important implications for developing film drainage theory to account for the effect of bubble translational and volumetric oscillations, bubble surface fluctuations and microstreaming.

  9. Helium Bubble Injection Solution To The Cavitation Damage At The Spallation Neutron Source

    SciTech Connect

    Francis, M. W.; Ruggles, A. E.

    2009-03-10

    The Spallation Neutron Source (SNS) is one of the largest science projects in the United States, with total cost near 1.4 Billion Dollars. The limiting factor of the facility had always been assumed to be the lifetime of the target window due to radiation damage. After further investigation, the lifetime of the target was determined not to be limited by radiation damage but by cavitation damage. The cavitation damage derives from pressure waves caused by the beam energy deposition. Vapor bubbles form when low to negative pressures occur in the mercury near the stainless steel target window due to wave interaction with the structure. Collapse of these bubbles can focus wave energy in small liquid jets that erode the window surface. Compressibility of the mercury can be enhanced to reduce the amplitude of the pressure wave caused by the beam energy deposition. To enhance compressibility, small (10 to 30 micron diameter) gas bubbles could be injected into the bulk of the mercury. Solubility and diffusivity parameters of inert gas in mercury are required for a complete mechanical simulation and engineering of these strategies. Using current theoretical models, one obtains a theoretical Henry coefficient of helium in mercury on the order of 3.9E15 Pa-molHg/molHe at 300 K. This low solubility was confirmed by a direct, offline experimental method. Mercury was charged with helium and any pressure change was recorded. Any pressure change was attributed to gas going into solution. Therefore, with the sensitivity of the experiment, a lower limit of 9E12 Pa-molHg/molHe was placed on the mercury-helium system. These values guarantee a stable bubble lifetime needed within the SNS mercury target to mitigate cavitation issues.

  10. Transient trapping of two microparticles interacting with optical tweezers and cavitation bubbles

    NASA Astrophysics Data System (ADS)

    Carmona-Sosa, Viridiana; Quinto-Su, Pedro A.

    2016-10-01

    In this work we show that two absorbing microbeads can briefly share the same optical trap while creating microscopic explosions. Optical forces pull the particles towards the waist of the trapping beam, once a particle reaches the vicinity of the waist, the surrounding liquid is superheated creating an explosion or cavitation bubble that pushes the particle away while lengthening or shortening the trajectories of the surrounding particles. Hence effectively coupling all the trajectories to each cavitation event. We find that when two microbeads reach the waist simultaneously within a distance of 2.9 μ {{m}} from the beam center in the transverse plane, a larger explosion might result in ejection from the trap. The measured maximum radial displacements {{Δ }}{ρ }{{c}} due to cavitation are {{Δ }}{ρ }{{c}}=3.9+/- 2.2 μ {{m}} when the particles reach simultaneously with maximum bubble sizes {R}{{\\max }}=6.2+/- 3.1 μ {{m}}, while for individual cases {{Δ }}{ρ }{{c}} is 2.7+/- 1.2 μ {{m}} and {R}{{\\max }}=4.2+/- 1.6 μ {{m}}. We also measure the characteristic timescale of two particle coalescence which is a measure of the expected time that the particles can stay trapped near the waist. The measurements are fitted by a Poisson decaying exponential probability distribution. A simple one-dimensional model shows that the characteristic timescales for transient trapping of multiple absorbing particles decrease as more objects are added.

  11. A theoretical study of inertial cavitation from acoustic radiation force impulse (ARFI) imaging and implications for the mechanical index

    PubMed Central

    Church, Charles C.; Labuda, Cecille; Nightingale, Kathryn

    2014-01-01

    The mechanical index (MI) attempts to quantify the likelihood that exposure to diagnostic ultrasound will produce an adverse biological effect by a nonthermal mechanism. The current formulation of the MI implicitly assumes that the acoustic field is generated using the short pulse durations appropriate to B-mode imaging. However, acoustic radiation force impulse (ARFI) imaging employs high-intensity pulses up to several hundred acoustic periods long. The effect of increased pulse durations on the thresholds for inertial cavitation was studied computationally in water, urine, blood, cardiac and skeletal muscle, brain, kidney, liver and skin. The results show that while the effect of pulse duration on cavitation thresholds in the three liquids can be considerable, reducing them by, e.g., 6% – 24% at 1 MHz, the effect in tissue is minor. More importantly, the frequency dependence of the MI appears to be unnecessarily conservative, i.e., that the magnitude of the exponent on frequency could be increased to 0.75. Comparison of these theoretical results with experimental measurements suggests that some tissues do not contain the pre-existing, optimally sized bubbles assumed for the MI. This means that in these tissues the MI is not necessarily a strong predictor of the probability for an adverse biological effect. PMID:25592457

  12. Interaction Mechanisms of Cavitation Bubbles Induced by Spatially and Temporally Separated fs-Laser Pulses

    PubMed Central

    Tinne, Nadine; Kaune, Brigitte; Krüger, Alexander; Ripken, Tammo

    2014-01-01

    The emerging use of femtosecond lasers with high repetition rates in the MHz regime together with limited scan speed implies possible mutual optical and dynamical interaction effects of the individual cutting spots. In order to get more insight into the dynamics a time-resolved photographic analysis of the interaction of cavitation bubbles is presented. Particularly, we investigated the influence of fs-laser pulses and their resulting bubble dynamics with various spatial as well as temporal separations. Different time courses of characteristic interaction effects between the cavitation bubbles were observed depending on pulse energy and spatio-temporal pulse separation. These ranged from merely no interaction to the phenomena of strong water jet formation. Afterwards, the mechanisms are discussed regarding their impact on the medical application of effective tissue cutting lateral to the laser beam direction with best possible axial precision: the mechanical forces of photodisruption as well as the occurring water jet should have low axial extend and a preferably lateral priority. Furthermore, the overall efficiency of energy conversion into controlled mechanical impact should be maximized compared to the transmitted pulse energy and unwanted long range mechanical side effects, e.g. shock waves, axial jet components. In conclusion, these experimental results are of great importance for the prospective optimization of the ophthalmic surgical process with high-repetition rate fs-lasers. PMID:25502697

  13. Interaction mechanisms of cavitation bubbles induced by spatially and temporally separated fs-laser pulses.

    PubMed

    Tinne, Nadine; Kaune, Brigitte; Krüger, Alexander; Ripken, Tammo

    2014-01-01

    The emerging use of femtosecond lasers with high repetition rates in the MHz regime together with limited scan speed implies possible mutual optical and dynamical interaction effects of the individual cutting spots. In order to get more insight into the dynamics a time-resolved photographic analysis of the interaction of cavitation bubbles is presented. Particularly, we investigated the influence of fs-laser pulses and their resulting bubble dynamics with various spatial as well as temporal separations. Different time courses of characteristic interaction effects between the cavitation bubbles were observed depending on pulse energy and spatio-temporal pulse separation. These ranged from merely no interaction to the phenomena of strong water jet formation. Afterwards, the mechanisms are discussed regarding their impact on the medical application of effective tissue cutting lateral to the laser beam direction with best possible axial precision: the mechanical forces of photodisruption as well as the occurring water jet should have low axial extend and a preferably lateral priority. Furthermore, the overall efficiency of energy conversion into controlled mechanical impact should be maximized compared to the transmitted pulse energy and unwanted long range mechanical side effects, e.g. shock waves, axial jet components. In conclusion, these experimental results are of great importance for the prospective optimization of the ophthalmic surgical process with high-repetition rate fs-lasers.

  14. An acoustical bubble counter for superheated drop detectors.

    PubMed

    Taylor, Chris; Montvila, Darius; Flynn, David; Brennan, Christopher; d'Errico, Francesco

    2006-01-01

    A new bubble counter has been developed based on the well-established approach of detecting vaporization events acoustically in superheated drop detectors (SDDs). This counter is called the Framework Scientific ABC 1260, and it represents a major improvement over prior versions of this technology. By utilizing advanced acoustic pattern recognition software, the bubble formation event can be differentiated from ambient background noise, as well as from other acoustic signatures. Additional structural design enhancements include a relocation of the electronic components to the bottom of the device; thus allowing for greater stability, easier access to vial SDDs without exposure to system electronics. Upgrades in the electronics permit an increase in the speed of bubble detection by almost 50%, compared with earlier versions of the counters. By positioning the vial on top of the device, temperature and sound insulation can be accommodated for extreme environments. Lead shells can also be utilized for an enhanced response to high-energy neutrons. PMID:16891351

  15. Study on the spatial distribution of the liquid temperature near a cavitation bubble wall.

    PubMed

    Shen, Yang; Yasui, Kyuichi; Sun, Zhicheng; Mei, Bin; You, Meiyan; Zhu, Tong

    2016-03-01

    A simple new model of the spatial distribution of the liquid temperature near a cavitation bubble wall (Tli) is employed to numerically calculate Tli. The result shows that Tli is almost same with the ambient liquid temperature (T0) during the bubble oscillations except at strong collapse. At strong collapse, Tli can increase to about 1510 K, the same order of magnitude with that of the maximum temperature inside the bubble, which means that the chemical reactions occur not only in gas-phase inside the collapsing bubble but also in liquid-phase just outside the collapsing bubble. Four factors (ultrasonic vibration amplitude, ultrasonic frequency, the surface tension and the viscosity) are considered to study their effects for the thin liquid layer. The results show that for the thin layer, the thickness and the temperature increase as the ultrasonic vibration amplitude rise; conversely, the thickness and the temperature decrease with the increase of the ultrasonic frequency, the surface tension or the viscosity. PMID:26585020

  16. Acoustic cavitation in phacoemulsification and the role of antioxidants.

    PubMed

    Topaz, Moris; Shuster, Vladimir; Assia, Ehud I; Meyerstein, Dan; Meyerstein, Naomi; Mazor, Dalia; Gedanken, Aharon

    2005-08-01

    Cataract surgery by phacoemulsification generates acoustic cavitation, resulting in formation of reactive oxygen species. The aim of this study was to establish the mechanism of damage by phacoemulsification in an in vitro setting simulating cataract surgery and to assess the protective effects of water-soluble antioxidants. Electron paramagnetic resonance spectroscopy was used to analyze generation of radicals in an intraocular irrigating solution by phacoemulsification instrumentation, operating at an ultrasonic frequency range of 40--60 kHz. Hydroxyl radicals were generated by phacoemulsification under conditions simulating cataract surgery. The effects of water-soluble antioxidants in the irrigating solution on the amounts of radicals were evaluated by electron paramagnetic resonance spectroscopy. The water-soluble antioxidant glutathione, applied in either oxidized or reduced form, decreased hydroxyl radicals concentration measured in the sonicated medium. The effective concentrations of oxidized and reduced glutathione in irrigating solution that significantly eliminate the hydroxyl radical signal were determined in the range of 10(-3)-10(-2) M. Antioxidants should be applied clinically to reduce damage to the corneal endothelium induced by phacoemulsification, thereby improving biosafety.

  17. The acoustic signature of bubbles fragmenting in sheared flow.

    PubMed

    Deane, Grant B; Stokes, M Dale

    2006-12-01

    Measurements of the sound of bubbles fragmenting in fluid shear are presented and analyzed. The frequency, amplitude, and decay rate of the acoustic emissions from 1.8-mm-radius bubbles fragmenting between opposed fluid jets have been determined. A broad band of frequencies (1.8 to 30 kHz) is observed with peak pressure amplitudes in the range of 0.03 to 2 Pa. While the peak pressure amplitudes show no significant scaling with frequency, the frequency dependence of the decay rates is consistent with the sum of thermal and acoustic radiation losses.

  18. Applications of Acoustics and Cavitation to Noninvasive Therapy and Drug Delivery

    NASA Astrophysics Data System (ADS)

    Coussios, Constantin C.; Roy, Ronald A.

    2008-01-01

    Biomedical acoustics is rapidly evolving from a diagnostic modality into a therapeutic tool, and acoustic cavitation is often the common denominator in a wide range of new therapeutic applications. High-intensity focused ultrasound (HIFU) waves generated outside the body can be used to deposit heat deep within the body. Through a quantitative analysis of heat deposition by ultrasound, it is shown that inertial cavitation can help address some of the major challenges of HIFU therapy by providing a means of enhancing and monitoring treatment noninvasively. In the context of drug delivery, both inertial and stable cavitation play roles in enhancing drug activity and uptake. In particular, shape oscillations arising during stable cavitation provide an effective micropumping mechanism for enhanced mass transport across inaccessible interfaces.

  19. Bubble-induced acoustic mixing in a microfluidic device

    NASA Astrophysics Data System (ADS)

    Chen, Huaying; Petkovic-Duran, Karolina; Best, Michael; Zhu, Yonggang

    2015-12-01

    Homogeneous and fast mixing of samples at microscale is a critical requirement for successful applications of microfluidics in biochemical analysis, chemical synthesis, drug delivery and nanomaterial synthesis. This paper reports the optimisation of bubble-induced mixing in a microfluidic device in terms of voltage, driving frequency, piezo transducer position and PDMS thickness. The microfluidic device consists of a microwell (with the diameter of 1mm and volume of ~95 nL) with two rectangular bubble traps (400×400μm) on both sides of the well. After the injection of liquid, air bubbles were spontaneously trapped in two rectangular traps. When the frequency of a piezo was equal to the resonance frequency of air bubbles, strong liquid recirculation formed (so called acoustic microstreaming) in the vicinity of the interface of air bubbles and water. The acoustic induced flow of microbeads and mixing of water and fluorescence dye were imaged to study the mixing efficiency. For a given voltage and PDMS thickness, when the piezo was placed on top of the well, the mixing was most vigorous. For a given frequency, the mixing efficiency was directly proportional to the voltage (4-20V) and inversely proportional to the PDMS thickness (0.3-2mm). When the frequency driving the piezo was approaching the resonance frequency of air bubbles, the mixing efficiency was maximal, while when it was far away from the resonance frequency of air bubbles, the mixing efficiency was much lower. This work provides guidance to the design and the application of bubble-induced acoustic mixing in microfluidics.

  20. Dynamics of two interacting hydrogen bubbles in liquid aluminum under the influence of a strong acoustic field

    NASA Astrophysics Data System (ADS)

    Lebon, Gerard S. B.; Pericleous, Koulis; Tzanakis, Iakovos; Eskin, Dmitry G.

    2015-10-01

    Ultrasonic melt processing significantly improves the properties of metallic materials. However, this promising technology has not been successfully transferred to the industry because of difficulties in treating large volumes of melt. To circumvent these difficulties, a fundamental understanding of the efficiency of ultrasonic treatment of liquid metals is required. In this endeavor, the dynamics of two interacting hydrogen bubbles in liquid aluminum are studied to determine the effect of a strong acoustic field on their behavior. It is shown that coalescence readily occurs at low frequencies in the range of 16 to 20 kHz; forcing frequencies at these values are likely to promote degassing. Emitted acoustic pressures from relatively isolated bubbles that resonate with the driving frequency are in the megapascal range and these cavitation shock waves are presumed to promote grain refinement by disrupting the growth of the solidification front.

  1. Dynamics of two interacting hydrogen bubbles in liquid aluminum under the influence of a strong acoustic field.

    PubMed

    Lebon, Gerard S B; Pericleous, Koulis; Tzanakis, Iakovos; Eskin, Dmitry G

    2015-10-01

    Ultrasonic melt processing significantly improves the properties of metallic materials. However, this promising technology has not been successfully transferred to the industry because of difficulties in treating large volumes of melt. To circumvent these difficulties, a fundamental understanding of the efficiency of ultrasonic treatment of liquid metals is required. In this endeavor, the dynamics of two interacting hydrogen bubbles in liquid aluminum are studied to determine the effect of a strong acoustic field on their behavior. It is shown that coalescence readily occurs at low frequencies in the range of 16 to 20 kHz; forcing frequencies at these values are likely to promote degassing. Emitted acoustic pressures from relatively isolated bubbles that resonate with the driving frequency are in the megapascal range and these cavitation shock waves are presumed to promote grain refinement by disrupting the growth of the solidification front. PMID:26565329

  2. Toward a reference ultrasonic cavitation vessel: Part 2--investigating the spatial variation and acoustic pressure threshold of inertial cavitation in a 25 kHz ultrasound field.

    PubMed

    Hodnett, Mark; Zeqiri, Bajram

    2008-08-01

    As part of an ongoing project to establish a reference facility for acoustic cavitation at the National Physical Laboratory (NPL), carefully controlled studies on a 25 kHz, 1.8 kW cylindrical vessel are described. Using a patented high-frequency acoustic emission detection method and a sonar hydrophone, results are presented of the spatial variation of inertial acoustic cavitation with increasing peak-negative pressure. Results show that at low operating levels, inertial acoustic cavitation is restricted to, and is strongly localized on, the vessel axis. At intermediate power settings, inertial acoustic cavitation also occurs close to the vessel walls, and at higher settings, a complex spatial variation is seen that is not apparent in measurements of the 25 kHz driving field alone. At selected vessel locations, a systematic investigation of the inertial cavitation threshold is described. This was carried out by making simultaneous measurements of the peak-negative pressures leading to inertial cavitation and the resultant MHz-frequency emissions, and indicates an inertial cavitation threshold of 101 kPa +/- 14% (estimated expanded uncertainty). However, an intermediate threshold at 84 kPa +/- 14% (estimated expanded uncertainty) is also seen. The results are discussed alongside theoretical predictions and recent experimental findings.

  3. Acoustic Sensor Design for Dark Matter Bubble Chamber Detectors.

    PubMed

    Felis, Ivan; Martínez-Mora, Juan Antonio; Ardid, Miguel

    2016-01-01

    Dark matter bubble chamber detectors use piezoelectric sensors in order to detect and discriminate the acoustic signals emitted by the bubbles grown within the superheated fluid from a nuclear recoil produced by a particle interaction. These sensors are attached to the outside walls of the vessel containing the fluid. The acoustic discrimination depends strongly on the properties of the sensor attached to the outer wall of the vessel that has to meet the requirements of radiopurity and size. With the aim of optimizing the sensor system, a test bench for the characterization of the sensors has been developed. The sensor response for different piezoelectric materials, geometries, matching layers, and backing layers have been measured and contrasted with FEM simulations and analytical models. The results of these studies lead us to have a design criterion for the construction of specific sensors for the next generation of dark matter bubble chamber detectors (250 L). PMID:27294937

  4. Acoustic Sensor Design for Dark Matter Bubble Chamber Detectors.

    PubMed

    Felis, Ivan; Martínez-Mora, Juan Antonio; Ardid, Miguel

    2016-06-10

    Dark matter bubble chamber detectors use piezoelectric sensors in order to detect and discriminate the acoustic signals emitted by the bubbles grown within the superheated fluid from a nuclear recoil produced by a particle interaction. These sensors are attached to the outside walls of the vessel containing the fluid. The acoustic discrimination depends strongly on the properties of the sensor attached to the outer wall of the vessel that has to meet the requirements of radiopurity and size. With the aim of optimizing the sensor system, a test bench for the characterization of the sensors has been developed. The sensor response for different piezoelectric materials, geometries, matching layers, and backing layers have been measured and contrasted with FEM simulations and analytical models. The results of these studies lead us to have a design criterion for the construction of specific sensors for the next generation of dark matter bubble chamber detectors (250 L).

  5. Acoustic Sensor Design for Dark Matter Bubble Chamber Detectors

    PubMed Central

    Felis, Ivan; Martínez-Mora, Juan Antonio; Ardid, Miguel

    2016-01-01

    Dark matter bubble chamber detectors use piezoelectric sensors in order to detect and discriminate the acoustic signals emitted by the bubbles grown within the superheated fluid from a nuclear recoil produced by a particle interaction. These sensors are attached to the outside walls of the vessel containing the fluid. The acoustic discrimination depends strongly on the properties of the sensor attached to the outer wall of the vessel that has to meet the requirements of radiopurity and size. With the aim of optimizing the sensor system, a test bench for the characterization of the sensors has been developed. The sensor response for different piezoelectric materials, geometries, matching layers, and backing layers have been measured and contrasted with FEM simulations and analytical models. The results of these studies lead us to have a design criterion for the construction of specific sensors for the next generation of dark matter bubble chamber detectors (250 L). PMID:27294937

  6. Electromagnetically actuated micromanipulator using an acoustically oscillating bubble

    NASA Astrophysics Data System (ADS)

    Kwon, J. O.; Yang, J. S.; Lee, S. J.; Rhee, K.; Chung, S. K.

    2011-11-01

    A novel non-invasive micromanipulation technique has been developed where a microrobot swimming in an aqueous medium manipulates micro-objects, through electromagnetic actuation using an acoustically oscillating bubble attached to the microrobot as a grasping tool. This micromanipulation concept was experimentally verified; an investigation of electromagnetic actuation and acoustic excitation was also performed. Two-dimensional propulsion of a magnetic piece was demonstrated through electromagnetic actuation, using three pairs of electric coils surrounding the water chamber, and confirming that the propulsion speed of the magnetic piece was linearly proportional to the applied current intensity. Micro-object manipulation was separately demonstrated using an air bubble with glass beads (80 µm diameter) and a steel ball (800 µm diameter) in an aqueous medium. Upon acoustic excitation of the bubble by a piezo-actuator around its resonant frequency, the generated radiation force attracted and captured the neighboring glass beads and steel ball. The grasping force was indirectly measured by exposing the glass beads captured by the oscillating bubble to a stream generated by an auto-syringe pump in a mini-channel. By measuring the maximum speed of the streaming flow when the glass beads detached from the oscillating bubble and flowed downstream, the grasping force was calculated as 50 nN, based on Stokes' drag approximation. Finally, a fish egg was successfully manipulated with the integration of electromagnetic actuation and acoustic excitation, using a mini-robot consisting of a millimeter-sized magnetic piece with a bubble attached to its bottom. This novel micromanipulation may be an efficient tool for both micro device assembly and single-cell manipulation.

  7. Identification of cavitation signatures using both optical and PZT acoustic sensors

    NASA Astrophysics Data System (ADS)

    Vidakovic, M.; Armakolas, I.; Sun, T.; Carlton, J.; Grattan, K. T. V.

    2015-09-01

    This paper presents the results obtained from monitoring a simulated material cavitation process using both a fibre Bragg grating (FBG)-based acoustic sensor system developed at City University London and a commercial PZT (Piezoelectric Transducer) acoustic sensor, with an aim to identify the cavitation signatures. In the experiment, a sample metal plate with its back surface being instrumented with both sensors is positioned very close to an excitation sonotrode with a standard frequency of 19.5kHz. The data obtained from both sensors are recorded and analyzed, showing a very good agreement.

  8. Nuclear Emissions During Self-Nucleated Acoustic Cavitation

    SciTech Connect

    Taleyarkhan, R.P.; Xu, Y.; West, C.D.; Lahey, R.T. Jr.; Block, R.C.; Nigmatulin, R.I.

    2006-01-27

    A unique, new stand-alone acoustic inertial confinement nuclear fusion test device was successfully tested. Experiments using four different liquid types were conducted in which bubbles were self-nucleated without the use of external neutrons. Four independent detection systems were used (i.e., a neutron track plastic detector to provide unambiguous visible records for fast neutrons, a BF{sub 3} detector, a NE-113-type liquid scintillation detector, and a NaI {gamma} ray detector). Statistically significant nuclear emissions were observed for deuterated benzene and acetone mixtures but not for heavy water. The measured neutron energy was {<=}2.45 MeV, which is indicative of deuterium-deuterium (D-D) fusion. Neutron emission rates were in the range {approx}5x10{sup 3} n/s to {approx}10{sup 4} n/s and followed the inverse law dependence with distance. Control experiments did not result in statistically significant neutron or {gamma} ray emissions.

  9. Influences of non-uniform pressure field outside bubbles on the propagation of acoustic waves in dilute bubbly liquids.

    PubMed

    Zhang, Yuning; Du, Xiaoze

    2015-09-01

    Predictions of the propagation of the acoustic waves in bubbly liquids is of great importance for bubble dynamics and related applications (e.g. sonochemistry, sonochemical reactor design, biomedical engineering). In the present paper, an approach for modeling the propagation of the acoustic waves in dilute bubbly liquids is proposed through considering the non-uniform pressure field outside the bubbles. This approach is validated through comparing with available experimental data in the literature. Comparing with the previous models, our approach mainly improves the predictions of the attenuation of acoustic waves in the regions with large kR0 (k is the wave number and R0 is the equilibrium bubble radius). Stability of the oscillating bubbles under acoustic excitation are also quantitatively discussed based on the analytical solution.

  10. Influence of the vibro-acoustic sensor position on cavitation detection in a Kaplan turbine

    NASA Astrophysics Data System (ADS)

    Schmidt, H.; Kirschner, O.; Riedelbauch, S.; Necker, J.; Kopf, E.; Rieg, M.; Arantes, G.; Wessiak, M.; Mayrhuber, J.

    2014-03-01

    Hydraulic turbines can be operated close to the limits of the operating range to meet the demand of the grid. When operated close to the limits, the risk increases that cavitation phenomena may occur at the runner and / or at the guide vanes of the turbine. Cavitation in a hydraulic turbine can cause material erosion on the runner and other turbine parts and reduce the durability of the machine leading to required outage time and related repair costs. Therefore it is important to get reliable information about the appearance of cavitation during prototype operation. In this experimental investigation the high frequency acoustic emissions and vibrations were measured at 20 operating points with different cavitation behaviour at different positions in a large prototype Kaplan turbine. The main goal was a comparison of the measured signals at different sensor positions to identify the sensitivity of the location for cavitation detection. The measured signals were analysed statistically and specific values were derived. Based on the measured signals, it is possible to confirm the cavitation limit of the examined turbine. The result of the investigation shows that the position of the sensors has a significant influence on the detection of cavitation.

  11. Comment on "Acoustical observation of bubble oscillations induced by bubble popping"

    NASA Astrophysics Data System (ADS)

    Blanc, É.; Ollivier, F.; Antkowiak, A.; Wunenburger, R.

    2015-03-01

    We have reproduced the experiment of acoustic monitoring of spontaneous popping of single soap bubbles standing in air reported by Ding et al. [2aa Phys. Rev. E 75, 041601 (2007), 10.1103/PhysRevE.75.041601]. By using a single microphone and two different signal acquisition systems recording in parallel the signal at the microphone output, among them the system used by Ding et al., we have experimentally evidenced that the acoustic precursors of bubble popping events detected by Ding et al. actually result from an acausal artifact of the signal processing performed by their acquisition system which lies outside of its prescribed working frequency range. No acoustic precursor of popping could be evidenced with the microphone used in these experiments, whose sensitivity is 1 V Pa-1 and frequency range is 500 Hz-100 kHz.

  12. Comment on "Acoustical observation of bubble oscillations induced by bubble popping".

    PubMed

    Blanc, É; Ollivier, F; Antkowiak, A; Wunenburger, R

    2015-03-01

    We have reproduced the experiment of acoustic monitoring of spontaneous popping of single soap bubbles standing in air reported by Ding et al. [2aaPhys. Rev. E 75, 041601 (2007)]. By using a single microphone and two different signal acquisition systems recording in parallel the signal at the microphone output, among them the system used by Ding et al., we have experimentally evidenced that the acoustic precursors of bubble popping events detected by Ding et al. actually result from an acausal artifact of the signal processing performed by their acquisition system which lies outside of its prescribed working frequency range. No acoustic precursor of popping could be evidenced with the microphone used in these experiments, whose sensitivity is 1VPa-1 and frequency range is 500 Hz-100 kHz. PMID:25871255

  13. Cavitation propagation in water under tension

    NASA Astrophysics Data System (ADS)

    Noblin, Xavier; Yip Cheung Sang, Yann; Pellegrin, Mathieu; Materials and Complex Fluids Team

    2012-11-01

    Cavitation appears when pressure decreases below vapor pressure, generating vapor bubbles. It can be obtain in dynamical ways (acoustic, hydraulic) but also in quasi-static conditions. This later case is often observed in nature, in trees, or during the ejection of ferns spores. We study the cavitation bubbles nucleation dynamics and its propagation in a confined microfabricated media. This later is an ordered array of microcavities made in hydrogel filled with water. When the system is put into dry air, it dehydrates, water leaves the cavities and tension (negative pressure) builds in the cavities. This can be sustained up to a critical pressure (of order -20 MPa), then cavitation bubbles appear. We follow the dynamics using ultra high speed imaging. Events with several bubbles cavitating in a few microseconds could be observed along neighboring cells, showing a propagation phenomenon that we discuss. ANR CAVISOFT 2010-JCJC-0407 01.

  14. Blowing Polymer Bubbles in an Acoustic Levitator

    NASA Technical Reports Server (NTRS)

    Lee, M. C.

    1985-01-01

    In new manufacturing process, small gas-filled polymer shells made by injecting gas directly into acoustically levitated prepolymer drops. New process allows sufficient time for precise control of shell geometry. Applications foreseen in fabrication of deuterium/tritium-filled fusion targets and in pharmaceutical coatings. New process also useful in glass blowing and blow molding.

  15. Studies on the Tempo of Bubble Formation in Recently Cavitated Vessels: A Model to Predict the Pressure of Air Bubbles1

    PubMed Central

    Wang, Yujie; Pan, Ruihua; Tyree, Melvin T.

    2015-01-01

    A cavitation event in a vessel replaces water with a mixture of water vapor and air. A quantitative theory is presented to argue that the tempo of filling of vessels with air has two phases: a fast process that extracts air from stem tissue adjacent to the cavitated vessels (less than 10 s) and a slow phase that extracts air from the atmosphere outside the stem (more than 10 h). A model was designed to estimate how water tension (T) near recently cavitated vessels causes bubbles in embolized vessels to expand or contract as T increases or decreases, respectively. The model also predicts that the hydraulic conductivity of a stem will increase as bubbles collapse. The pressure of air bubbles trapped in vessels of a stem can be predicted from the model based on fitting curves of hydraulic conductivity versus T. The model was validated using data from six stem segments each of Acer mono and the clonal hybrid Populus 84K (Populus alba × Populus glandulosa). The model was fitted to results with root mean square error less than 3%. The model provided new insight into the study of embolism formation in stem tissue and helped quantify the bubble pressure immediately after the fast process referred to above. PMID:25907963

  16. Spectrum of laser light scattered by nanoparticles in an ablation-induced cavitation bubble

    NASA Astrophysics Data System (ADS)

    Takeuchi, Masato; Sasaki, Koichi

    2016-04-01

    The spectrum of the laser light scattered by nanoparticles in a cavitation bubble, which was induced by laser ablation of a titanium target in water, was measured using a triple-grating spectrograph. The scattered laser light observed at 100 \\upmu s after laser ablation had no wavelength-shifted component, suggesting that nanoparticles at this delay time were metallic. The wavelength-shifted component was observed in the spectrum at a delay time of 200 \\upmu s, suggesting the formation of oxidized nanoparticles. However, we observed no peaks in the spectrum of the scattered laser light in the present in situ laser-light scattering experiment. On the other hand, we observed clear peaks in the Raman spectrum of synthesized nanoparticles. The experimental results suggest slow crystallization of nanoparticles in liquid in liquid-phase laser ablation.

  17. Detection of acoustic emission from cavitation in tissue during clinical extracorporeal lithotripsy.

    PubMed

    Coleman, A J; Choi, M J; Saunders, J E

    1996-01-01

    A 1-MHz focused hydrophone has been used to search for acoustic emission expected to arise from cavitation occurring in tissue during clinical extracorporeal shock-wave lithotripsy (ESWL). The hydrophone is acoustically coupled to the patient's skin and the focus directed at depth in tissue under ultrasound guidance. The measured amplitude-time variation of the acoustic emission from tissue near the shock-wave focus of the Storz Modulith SL20 lithotripter has been examined in four patients. There is evidence of increased amplitude acoustic emission at 1 MHz from regions within tissue that also appear hyperechoic in simultaneously acquired ultrasound images. The acoustic emission from these regions decays from an initial peak to the noise level in about 500 microseconds following each shock-wave pulse. Within this period, a second peak, often of higher amplitude than the first, is typically observed about 100 microseconds after the shockwave. The time between the initial and second peaks is found to increase with increasing shock-wave amplitude. The results are similar to those previously observed from cavitation induced by shock-wave exposure in water and indicate that the 1-MHz acoustic emission arises from inertial cavitation in tissue during clinical ESWL.

  18. Ultrahigh-Speed Dynamics of Micrometer-Scale Inertial Cavitation from Nanoparticles

    NASA Astrophysics Data System (ADS)

    Kwan, J. J.; Lajoinie, G.; de Jong, N.; Stride, E.; Versluis, M.; Coussios, C. C.

    2016-10-01

    Direct imaging of cavitation from solid nanoparticles has been a challenge due to the combined nanosized length and time scales involved. We report on high-speed microscopic imaging of inertial cavitation from gas trapped on nanoparticles with a tunable hemispherical depression (nanocups) at nanosecond time scales. The high-speed recordings establish that nanocups facilitate bubble growth followed by inertial collapse. Nanoparticle size, acoustic pressure amplitude, and frequency influence bubble dynamics and are compared to model predictions. Understanding these cavitation dynamics is critical for applications enhanced by acoustic cavitation.

  19. The Dynamics of Vapor Bubbles in Acoustic Pressure Fields

    NASA Technical Reports Server (NTRS)

    Hao, Y.; Prosperetti, A.

    1999-01-01

    In spite of a superficial similarity with gas bubbles, the intimate coupling between dynamical and thermal processes confers to oscillating vapor bubbles some unique characteristics. This paper examines numerically the validity of some asymptotic-theory predictions such as the existence of two resonant radii and a limit size for a given sound amplitude and frequency. It is found that a small vapor bubble in a sound field of sufficient amplitude grows quickly through resonance and continues to grow thereafter at a very slow rate, seemingly indefinitely. Resonance phenomena therefore play a role for a few cycles at most, and reaching a limit size-if one exists at all-is found to require far more than several tens of thousands of cycles. It is also found that some small bubbles may grow or collapse depending on the phase of the sound field. The model accounts in detail for the thermo-fluid-mechanic processes in the vapor. In the second part of the paper, an approximate formulation valid for bubbles small with respect to the thermal penetration length in the vapor is derived and its accuracy examined, The present findings have implications for acoustically enhanced boiling heat transfer and other special applications such as boiling in microgravity.

  20. ``Ultrasonic stars'' for time-reversal focusing using induced cavitation bubbles

    NASA Astrophysics Data System (ADS)

    Pernot, Mathieu; Montaldo, Gabriel; Tanter, Mickael; Fink, Mathias

    2006-01-01

    Ultrasound waves can be focused by multichannel arrays through heterogeneous media using a time-reversal focusing method. In this method, it is required that a reference signal be either sent by a small active source embedded in the medium or backscattered by a strong scatterer acting as a passive source. The potential of this method in ultrasonic medical imaging has been already envisioned for aberration corrections. However, in many practical situations it is not possible to insert an active source in the medium or to rely on the presence of a unique strong scatterer in order to generate the reference signal. Analogous to the field of adaptive optics in astronomy, we propose here to create artificial ``ultrasonic stars'' in the body. The trick consists of first creating a bubble inside the medium using a section of the ultrasonic array. Due to cavitation, the bubble generates a spherical wave that propagates through a heterogeneous medium to the ultrasound array. The time-reversal method is then applied to the ultrasonic wave received by the array. This technique is experimentally validated for aberrations corrections in tissue mimicking phantoms.

  1. Changes in cell morphology due to plasma membrane wounding by acoustic cavitation

    PubMed Central

    Schlicher, Robyn K.; Hutcheson, Joshua D.; Radhakrishna, Harish; Apkarian, Robert P.; Prausnitz, Mark R.

    2010-01-01

    Acoustic cavitation-mediated wounding (i.e., sonoporation) has great potential to improve medical and laboratory applications requiring intracellular uptake of exogenous molecules; however, the field lacks detailed understanding of cavitation-induced morphological changes in cells and their relative importance. Here, we present an in-depth study of the effects of acoustic cavitation on cells using electron and confocal microscopy coupled with quantitative flow cytometry. High resolution images of treated cells show that morphologically different types of blebs can occur after wounding conditions caused by ultrasound exposure as well as by mechanical shear and strong laser ablation. In addition, these treatments caused wound-induced non-lytic necrotic death resulting in cell bodies we call wound-derived perikarya (WD-P). However, only cells exposed to acoustic cavitation experienced ejection of intact nuclei and nearly instant lytic necrosis. Quantitative analysis by flow cytometry indicates that wound-derived perikarya are the dominant morphology of nonviable cells, except at the strongest wounding conditions, where nuclear ejection accounts for a significant portion of cell death after ultrasound exposure. PMID:20350691

  2. Energy analysis during acoustic bubble oscillations: relationship between bubble energy and sonochemical parameters.

    PubMed

    Merouani, Slimane; Hamdaoui, Oualid; Rezgui, Yacine; Guemini, Miloud

    2014-01-01

    In this work, energy analysis of an oscillating isolated spherical bubble in water irradiated by an ultrasonic wave has been theoretically studied for various conditions of acoustic amplitude, ultrasound frequency, static pressure and liquid temperature in order to explain the effects of these key parameters on both sonochemistry and sonoluminescence. The Keller-Miksis equation for the temporal variation of the bubble radius in compressible and viscous medium has been employed as a dynamics model. The numerical calculations showed that the rate of energy accumulation, dE/dt, increased linearly with increasing acoustic amplitude in the range of 1.5-3.0 atm and decreased sharply with increasing frequency in the range 200-1000 kHz. There exists an optimal static pressure at which the power w is highest. This optimum shifts toward a higher value as the acoustic amplitude increases. The energy of the bubble slightly increases with the increase in liquid temperature from 10 to 60 °C. The results of this study should be a helpful means to explain a variety of experimental observations conducted in the field of sonochemistry and sonoluminescence concerning the effects of operational parameters. PMID:23683796

  3. Instability of interfaces of gas bubbles in liquids under acoustic excitation with dual frequency.

    PubMed

    Zhang, Yuning; Du, Xiaoze; Xian, Haizhen; Wu, Yulin

    2015-03-01

    Instability of interfaces of gas bubbles in liquids under acoustic excitation with dual frequency is theoretically investigated. The critical bubble radii dividing stable and unstable regions of bubbles under dual-frequency acoustic excitation are strongly affected by the amplitudes of dual-frequency acoustic excitation rather than the frequencies of dual-frequency excitation. The limitation of the proposed model is also discussed with demonstrating examples.

  4. Active cavitation detection of asymmetrical inertial cavitation

    NASA Astrophysics Data System (ADS)

    Everbach, E. Carr

    2001-05-01

    The active cavitation detector (ACD) developed in Bob Apfel's laboratory has often been employed to quantify pressure thresholds for inception of symmetrical inertial cavitation of microbubbles. In the current application, however, a 30-MHz ACD interrogates individual echo-contrast agent bubbles adhering to a Mylar(TM) sheet that are driven into asymmetrical (jet-producing) collapse by a 1-MHz toneburst (>1 MPa pp). The resulting ACD output suggests that asymmetrical bubble collapse is slower than symmetrical collapse, producing less total radiated acoustic power. ACD output mixed with reference sinusoids at 30 MHz and low pass filtered yields Doppler signals that may be useful in quantifying asymmetrical collapses under biomedically relevant conditions, such as on endothelial walls.

  5. Strongly interacting bubbles under an ultrasonic horn.

    PubMed

    Yasui, Kyuichi; Iida, Yasuo; Tuziuti, Toru; Kozuka, Teruyuki; Towata, Atsuya

    2008-01-01

    Numerical simulations of bubble pulsations have been performed for a system of two bubble clouds in order to study the experimentally observed bubble motion under an ultrasonic horn by high-speed video camera. The comparison between the calculated results and the experimental observation of the bubble pulsation has indicated that the bubble pulsation is strongly influenced by the interaction with surrounding bubbles. The expansion of a bubble during the rarefaction phase of ultrasound is strongly reduced by the bubble-bubble interaction. Some bubbles move toward the horn tip due to the secondary Bjerknes force acting from the bubbles near the horn tip. It has also been shown that the acoustic amplitude in the liquid is strongly reduced by cavitation due to the decrease in acoustic radiation resistance.

  6. Detecting cavitation in mercury exposed to a high-energy pulsed proton beam

    SciTech Connect

    Manzi, Nicholas J; Chitnis, Parag V; Holt, Ray G; Roy, Ronald A; Cleveland, Robin O; Riemer, Bernie; Wendel, Mark W

    2010-01-01

    The Oak Ridge National Laboratory Spallation Neutron Source employs a high-energy pulsed proton beam incident on a mercury target to generate short bursts of neutrons. Absorption of the proton beam produces rapid heating of the mercury, resulting in the formation of acoustic shock waves and the nucleation of cavitation bubbles. The subsequent collapse of these cavitation bubbles promote erosion of the steel target walls. Preliminary measurements using two passive cavitation detectors (megahertz-frequency focused and unfocused piezoelectric transducers) installed in a mercury test target to monitor cavitation generated by proton beams with charges ranging from 0.041 to 4.1 C will be reported on. Cavitation was initially detected for a beam charge of 0.082 C by the presence of an acoustic emission approximately 250 s after arrival of the incident proton beam. This emission was consistent with an inertial cavitation collapse of a bubble with an estimated maximum bubble radius of 0.19 mm, based on collapse time. The peak pressure in the mercury for the initiation of cavitation was predicted to be 0.6 MPa. For a beam charge of 0.41 C and higher, the lifetimes of the bubbles exceeded the reverberation time of the chamber (~300 s), and distinct windows of cavitation activity were detected, a phenomenon that likely resulted from the interaction of the reverberation in the chamber and the cavitation bubbles.

  7. Efficient Generation of Cavitation Bubbles in Gel Phantom by Ultrasound Exposure with Negative-Followed by Positive-Peak-Pressure-Emphasized Waves

    NASA Astrophysics Data System (ADS)

    Yasuda, Jun; Asai, Ayumu; Yoshizawa, Shin; Umemura, Shin-ichiro

    2013-07-01

    Cavitation bubbles have much potential for emphasizing therapeutic treatments such as high-intensity focused ultrasound (HIFU) treatment, histotripsy, and sonodynamic therapy. Their highly efficient as well as controlled generation is important to utilize them effectively as well as safely. However, producing negative pressure over the cavitation threshold by focused ultrasound is difficult because of the nonlinear propagation combined with the focal phase shift. We have suggested a dual-frequency ultrasound exposure method, in which N- and P-waves emphasizing either the peak negative or positive pressure, respectively, are synthesized by superimposing the second harmonic onto the fundamental frequency. In this study, high-speed camera observation demonstrated that the exposure with N-waves immediately followed by P-waves could generate cavitation bubbles most efficiently in gel phantom. Furthermore, the measured negative and positive pressure distributions of the N- and P-wave fields, respectively, agreed well with the optically observed distributions of cavitation inception and cavitation cloud growth.

  8. High-speed observation of cavitation bubble cloud structures in the focal region of a 1.2 MHz high-intensity focused ultrasound transducer.

    PubMed

    Chen, Hong; Li, Xiaojing; Wan, Mingxi; Wang, Supin

    2007-03-01

    Cavitation bubble clouds in the focal region of HIFU play important roles in therapeutic applications of HIFU. Temporal evolution and spatial distribution of cavitation bubble clouds generated in the focal region of a 1.2 MHz single element concave HIFU transducer in water are investigated by high-speed photography. It is found that during the initial 600 micro s insonation cavitation bubble clouds organize to the "screw-like structure" or "cap-like structure". The screw-like structure is characterized by a nearly fixed tip at the geometrical focus of the HIFU transducer, and the cap-like structure is marked by a dent formed in the direction of ultrasound transmission. After 600 micro s, another two structures are recorded - "streamer structure" and "cluster structure". The streamer structure is also featured by a nearly fixed bottom position at the focus, while the cluster structure is distinguished by agglomerations of bubbles around the focus.

  9. High-speed observation of cavitation bubble cloud structures in the focal region of a 1.2 MHz high-intensity focused ultrasound transducer.

    PubMed

    Chen, Hong; Li, Xiaojing; Wan, Mingxi; Wang, Supin

    2007-03-01

    Cavitation bubble clouds in the focal region of HIFU play important roles in therapeutic applications of HIFU. Temporal evolution and spatial distribution of cavitation bubble clouds generated in the focal region of a 1.2 MHz single element concave HIFU transducer in water are investigated by high-speed photography. It is found that during the initial 600 micro s insonation cavitation bubble clouds organize to the "screw-like structure" or "cap-like structure". The screw-like structure is characterized by a nearly fixed tip at the geometrical focus of the HIFU transducer, and the cap-like structure is marked by a dent formed in the direction of ultrasound transmission. After 600 micro s, another two structures are recorded - "streamer structure" and "cluster structure". The streamer structure is also featured by a nearly fixed bottom position at the focus, while the cluster structure is distinguished by agglomerations of bubbles around the focus. PMID:17071124

  10. Characterization of acoustic droplet vaporization for control of bubble generation under flow conditions.

    PubMed

    Kang, Shih-Tsung; Huang, Yi-Luan; Yeh, Chih-Kuang

    2014-03-01

    This study investigated the manipulation of bubbles generated by acoustic droplet vaporization (ADV) under clinically relevant flow conditions. Optical microscopy and high-frequency ultrasound imaging were used to observe bubbles generated by 2-MHz ultrasound pulses at different time points after the onset of ADV. The dependence of the bubble population on droplet concentration, flow velocity, fluid viscosity and acoustic parameters, including acoustic pressure, pulse duration and pulse repetition frequency, was investigated. The results indicated that post-ADV bubble growth spontaneously driven by air permeation markedly affected the bubble population after insonation. The bubbles can grow to a stable equilibrium diameter as great as twice the original diameter in 0.5-1 s, as predicted by the theoretical calculation. The growth trend is independent of flow velocity, but dependent on fluid viscosity and droplet concentration, which directly influence the rate of gas uptake by bubbles and the rate of gas exchange across the wall of the semipermeable tube containing the bubbles and, hence, the gas content of the host medium. Varying the acoustic pressure does not markedly change the formation of bubbles as long as the ADV thresholds of most droplets are reached. Varying pulse duration and pulse repetition frequency markedly reduces the number of bubbles. Lengthening pulse duration favors the production of large bubbles, but reduces the total number of bubbles. Increasing the PRF interestingly provides superior performance in bubble disruption. These results also suggest that an ADV bubble population cannot be assessed simply on the basis of initial droplet size or enhancement of imaging contrast by the bubbles. Determining the optimal acoustic parameters requires careful consideration of their impact on the bubble population produced for different application scenarios.

  11. Acoustically coupled gas bubbles in fluids: time-domain phenomena.

    PubMed

    Feuillade, C

    2001-06-01

    In previous work [C. Feuillade, J. Acoust. Soc. Am. 98, 1178-1190 (1995)] a coupled oscillator formalism was introduced for describing collective resonances, scattering, and superresonances, of multiple gas bubbles in a fluid. Subsequently, time-domain investigations of the impulse response of coupled systems have disclosed the exact conditions which determine whether the ensemble scattering behavior should be described using: either (a), a multiple scattering; or (b), a self-consistent methodology. The determining factor is the Q of the individual scatterers, and their typical spatial separations in the medium. For highly damped or sparse systems, e.g., scattering from loose schools of swimbladder fish, or from a gassy seabed containing entrained bubbles, the multiple scatter counting approach should be applicable. For more strongly coupled systems, e.g., a dense cloud of resonating bubbles in the water column, energy exchange may be due primarily to radiative cycling rather than scattering, in which case a self-consistent approach is indicated. The result has implications for both volume and bottom scattering applications.

  12. Cavitation-induced fragmentation of an acoustically-levitated droplet

    NASA Astrophysics Data System (ADS)

    Gonzalez Avila, Silvestre Roberto; Ohl, Claus-Dieter

    2015-12-01

    In this paper we investigate the initial sequence of events that lead to the fragmentation of a millimetre sized water droplets when interacting with a focused ns-laser pulse. The experimental results show complex processes that result from the reflection of an initial shock wave from plasma generation with the soft boundary of the levitating droplet; furthermore, when the reflected waves from the walls of the droplet refocus they leave behind a trail of microbubbles that later act as cavitation inception regions. Numerical simulations of a shock wave impacting and reflecting from a soft boundary are also reported; the simulated results show that the lowest pressure inside the droplet occurs at the equatorial plane. The results of the numerical model display good agreement with the experimental results both in time and in space.

  13. The dynamics of histotripsy bubbles

    NASA Astrophysics Data System (ADS)

    Kreider, Wayne; Bailey, Michael R.; Sapozhnikov, Oleg A.; Khokhlova, Vera A.; Crum, Lawrence A.

    2011-09-01

    Histotripsy describes treatments in which high-amplitude acoustic pulses are used to excite bubbles and erode tissue. Though tissue erosion can be directly attributed to bubble activity, the genesis and dynamics of bubbles remain unclear. Histotripsy lesions that show no signs of thermal coagulative damage have been generated with two different acoustic protocols: relatively long acoustic pulses that produce local boiling within milliseconds and relatively short pulses that are higher in amplitude but likely do not produce boiling. While these two approaches are often distinguished as `boiling' versus `cavitation', such labels can obscure similarities. In both cases, a bubble undergoes large changes in radius and vapor is transported into and out of the bubble as it oscillates. Moreover, observations from both approaches suggest that bubbles grow to a size at which they cease to collapse violently. In order to better understand the dynamics of histotripsy bubbles, a single-bubble model has been developed that couples acoustically excited bubble motions to the thermodynamic state of the surrounding liquid. Using this model for bubbles exposed to histotripsy sound fields, simulations suggest that two mechanisms can act separately or in concert to lead to the typically observed bubble growth. First, nonlinear acoustic propagation leads to the evolution of shocks and an asymmetry in the positive and negative pressures that drive bubble motion. This asymmetry can have a rectifying effect on bubble oscillations whereby the bubble grows on average during each acoustic cycle. Second, vapor transport to/from the bubble tends to produce larger bubbles, especially at elevated temperatures. Vapor transport by itself can lead to rectified bubble growth when the ambient temperature exceeds 100 °C (`boiling') or local heating in the vicinity of the bubble leads to a superheated boundary layer.

  14. Towards a reference cavitating vessel Part III—design and acoustic pressure characterization of a multi-frequency sonoreactor

    NASA Astrophysics Data System (ADS)

    Wang, Lian; Memoli, Gianluca; Hodnett, Mark; Butterworth, Ian; Sarno, Dan; Zeqiri, Bajram

    2015-08-01

    A multi-frequency cavitation vessel (RV-multi) has been commissioned at the National Physical Laboratory (NPL, UK), with the aim of establishing a standard source of acoustic cavitation in water, with reference to which details of the cavitation process can be studied and cavitation measurement techniques evaluated. The vessel is a cylindrical cavity with a maximum capacity up to 17 L, and is designed to work at six frequency ranges, from 21 kHz to 136 kHz, under controlled temperature conditions. This paper discusses the design of RV-multi and reports experiments carried out to establish the reproducibility of the acoustic pressure field established within the vessel and its operating envelope, including sensitivity to aspects such as water depth and temperature. The acoustic field distribution was determined along the radial and depth directions within the vessel using a miniature hydrophone, for two input voltage levels under low power transducer excitation conditions (e.g. below the cavitation threshold). Particular care was taken in determining peak acoustic pressure locations, as these are critical for accompanying cavitation studies. Perturbations of the vessel by the measuring hydrophone were also monitored with a bottom-mounted pressure sensor.

  15. Air emission into a water shear layer through porous media. Part 2: Cavitation induced pressure attenuation

    SciTech Connect

    Myer, E.C.; Marboe, R.C.

    1994-12-31

    Cavitation near the casing of a hydroturbine can lead to damage through both cavitation erosion and mechanical vibration of the casing and the associated piping. Cavitation erosion results from the collapse of cavitation bubbles on or near a surface such as the casing wall. Mechanical vibrations transmitted to the casing directly through the collapse of bubbles on the casing wall indirectly through a coupling of the acoustic pressure pulse due to a nearby collapse on the turbine blade. Air emission along the casing can reduce the intensity of the tip vortex and the gap cavitation through ventilation of the cavity. Reduction in the machinery vibration is obtained by reduction of the intensity of cavitation bubble collapse and attenuation and scattering of the radiated acoustic pressure. This requires a bubble layer which may be introduced in the vicinity of the turbine blade tips. This layer remains for some distance downstream of the blades and is effective for attenuation of tip vortex induced noise and blade surface cavitation noise. For the purpose of characterizing this bubble layer within a water pipe, the authors spanned a pipe with a two dimensional hydrofoil and emitted air through porous media (20 and 100 micron porosity sintered stainless steel) into the shear flow over the hydrofoil. This paper is limited to an investigation of the attenuation of acoustic pressure propagating to the casing rather than the reduction in acoustic source level due to collapse cushioning effects.

  16. 2-D steering and propelling of acoustic bubble-powered microswimmers.

    PubMed

    Feng, Jian; Yuan, Junqi; Cho, Sung Kwon

    2016-06-21

    This paper describes bi-directional (linear and rotational) propelling and 2-D steering of acoustic bubble-powered microswimmers that are achieved in a centimeter-scale pool (beyond chip level scale). The core structure of a microswimmer is a microtube with one end open in which a gaseous bubble is trapped. The swimmer is propelled by microstreaming flows that are generated when the trapped bubble is oscillated by an external acoustic wave. The bubble oscillation and thus propelling force are highly dependent on the frequency of the acoustic wave and the bubble length. This dependence is experimentally studied by measuring the resonance behaviors of the testing pool and bubble using a laser Doppler vibrometer (LDV) and by evaluating the generated streaming flows. The key idea in the present 2-D steering is to utilize this dependence. Multiple bubbles with different lengths are mounted on a single microswimmer with a variety of arrangements. By controlling the frequency of the acoustic wave, only frequency-matched bubbles can strongly oscillate and generate strong propulsion. By arranging multiple bubbles of different lengths in parallel but with their openings opposite and switching the frequency of the acoustic wave, bi-directionally linear propelling motions are successfully achieved. The propelling forces are calculated by a CFD analysis using the Ansys Fluent® package. For bi-directional rotations, a similar method but with diagonal arrangement of bubbles on a rectangular swimmer is also applied. The rotation can be easily reversed when the frequency of the acoustic wave is switched. For 2-D steering, short bubbles are aligned perpendicular to long bubbles. It is successfully demonstrated that the microswimmer navigates through a T-junction channel under full control with and without carrying a payload. During the navigation, the frequency is the main control input to select and resonate targeted bubbles. All of these operations are achieved by a single

  17. 2-D steering and propelling of acoustic bubble-powered microswimmers.

    PubMed

    Feng, Jian; Yuan, Junqi; Cho, Sung Kwon

    2016-06-21

    This paper describes bi-directional (linear and rotational) propelling and 2-D steering of acoustic bubble-powered microswimmers that are achieved in a centimeter-scale pool (beyond chip level scale). The core structure of a microswimmer is a microtube with one end open in which a gaseous bubble is trapped. The swimmer is propelled by microstreaming flows that are generated when the trapped bubble is oscillated by an external acoustic wave. The bubble oscillation and thus propelling force are highly dependent on the frequency of the acoustic wave and the bubble length. This dependence is experimentally studied by measuring the resonance behaviors of the testing pool and bubble using a laser Doppler vibrometer (LDV) and by evaluating the generated streaming flows. The key idea in the present 2-D steering is to utilize this dependence. Multiple bubbles with different lengths are mounted on a single microswimmer with a variety of arrangements. By controlling the frequency of the acoustic wave, only frequency-matched bubbles can strongly oscillate and generate strong propulsion. By arranging multiple bubbles of different lengths in parallel but with their openings opposite and switching the frequency of the acoustic wave, bi-directionally linear propelling motions are successfully achieved. The propelling forces are calculated by a CFD analysis using the Ansys Fluent® package. For bi-directional rotations, a similar method but with diagonal arrangement of bubbles on a rectangular swimmer is also applied. The rotation can be easily reversed when the frequency of the acoustic wave is switched. For 2-D steering, short bubbles are aligned perpendicular to long bubbles. It is successfully demonstrated that the microswimmer navigates through a T-junction channel under full control with and without carrying a payload. During the navigation, the frequency is the main control input to select and resonate targeted bubbles. All of these operations are achieved by a single

  18. Cavitation-induced damage of soft materials by focused ultrasound bursts: A fracture-based bubble dynamics model.

    PubMed

    Movahed, Pooya; Kreider, Wayne; Maxwell, Adam D; Hutchens, Shelby B; Freund, Jonathan B

    2016-08-01

    A generalized Rayleigh-Plesset-type bubble dynamics model with a damage mechanism is developed for cavitation and damage of soft materials by focused ultrasound bursts. This study is linked to recent experimental observations in tissue-mimicking polyacrylamide and agar gel phantoms subjected to bursts of a kind being considered specifically for lithotripsy. These show bubble activation at multiple sites during the initial pulses. More cavities appear continuously through the course of the observations, similar to what is deduced in pig kidney tissues in shock-wave lithotripsy. Two different material models are used to represent the distinct properties of the two gel materials. The polyacrylamide gel is represented with a neo-Hookean elastic model and damaged based upon a maximum-strain criterion; the agar gel is represented with a strain-hardening Fung model and damaged according to the strain-energy-based Griffith's fracture criterion. Estimates based upon independently determined elasticity and viscosity of the two gel materials suggest that bubble confinement should be sufficient to prevent damage in the gels, and presumably injury in some tissues. Damage accumulation is therefore proposed to occur via a material fatigue, which is shown to be consistent with observed delays in widespread cavitation activity.

  19. Cavitation-induced damage of soft materials by focused ultrasound bursts: A fracture-based bubble dynamics model.

    PubMed

    Movahed, Pooya; Kreider, Wayne; Maxwell, Adam D; Hutchens, Shelby B; Freund, Jonathan B

    2016-08-01

    A generalized Rayleigh-Plesset-type bubble dynamics model with a damage mechanism is developed for cavitation and damage of soft materials by focused ultrasound bursts. This study is linked to recent experimental observations in tissue-mimicking polyacrylamide and agar gel phantoms subjected to bursts of a kind being considered specifically for lithotripsy. These show bubble activation at multiple sites during the initial pulses. More cavities appear continuously through the course of the observations, similar to what is deduced in pig kidney tissues in shock-wave lithotripsy. Two different material models are used to represent the distinct properties of the two gel materials. The polyacrylamide gel is represented with a neo-Hookean elastic model and damaged based upon a maximum-strain criterion; the agar gel is represented with a strain-hardening Fung model and damaged according to the strain-energy-based Griffith's fracture criterion. Estimates based upon independently determined elasticity and viscosity of the two gel materials suggest that bubble confinement should be sufficient to prevent damage in the gels, and presumably injury in some tissues. Damage accumulation is therefore proposed to occur via a material fatigue, which is shown to be consistent with observed delays in widespread cavitation activity. PMID:27586763

  20. Target geometry and rigidity determines laser-induced cavitation bubble transport and nanoparticle productivity - a high-speed videography study.

    PubMed

    Kohsakowski, Sebastian; Gökce, Bilal; Tanabe, Rie; Wagener, Philipp; Plech, Anton; Ito, Yoshiro; Barcikowski, Stephan

    2016-06-28

    Laser-induced cavitation has mostly been studied in bulk liquid or at a two-dimensional wall, although target shapes for the particle synthesis may strongly affect bubble dynamics and interfere with particle productivity. We investigated the dynamics of the cavitation bubble induced by pulsed-laser ablation in liquid for different target geometries with high-speed laser microsecond videography and focus on the collapse behaviour. This method enables us observations in a high time resolution (intervals of 1 μs) and single-pulse experiments. Further, we analyzed the nanoparticle productivity, the sizes of the synthesized nanoparticles and the evolution of the bubble volume for each different target shape and geometry. For the ablation of metal (Ag, Cu, Ni) wire tips a springboard-like behaviour after the first collapse is observed which can be correlated with vertical projectile motion. Its turbulent friction in the liquid causes a very efficient transport and movement of the bubble and ablated material into the bulk liquid and prevents particle redeposition. This effect is influenced by the degree of freedom of the wire as well as the material properties and dimensions, especially the Young's modulus. The most efficient and largest bubble movement away from the wire was observed for a thin (500 μm) silver wire with velocities up to 19.8 m s(-1) and for materials with a small Young's modulus and flexural rigidity. We suggest that these observations may contribute to upscaling strategies and increase of particle yield towards large synthesis of colloids based on targets that may continuously be fed. PMID:27273693

  1. The role of energy density and acoustic cavitation in shock wave lithotripsy.

    PubMed

    Loske, Achim M

    2010-02-01

    Today a high percentage of urinary stones are successfully treated by extracorporeal shockwave lithotripsy (SWL); however, misconceptions regarding fragmentation mechanisms, as well as treatment parameters like dose, applied energy and focal area are still common. A main stone comminution mechanism during SWL is acoustic cavitation. The objective of this study was to analyze the influence of cavitation and energy density on stone fragmentation. A research lithotripter was used to expose a large set of artificial kidney stones to shock waves varying different parameters. Hundreds of pressure records were used to calculate the energy density of the lithotripter at different settings. Results indicate that energy density is a crucial parameter and that better SWL treatment outcomes could be obtained placing the calculus at a prefocal position.

  2. Extremely Efficient Liquid Exfoliation and Dispersion of Layered Materials by Unusual Acoustic Cavitation

    PubMed Central

    Han, Joong Tark; Jang, Jeong In; Kim, Haena; Hwang, Jun Yeon; Yoo, Hyung Keun; Woo, Jong Seok; Choi, Sua; Kim, Ho Young; Jeong, Hee Jin; Jeong, Seung Yol; Baeg, Kang-Jun; Cho, Kilwon; Lee, Geon-Woong

    2014-01-01

    Layered materials must be exfoliated and dispersed in solvents for diverse applications. Usually, highly energetic probe sonication may be considered to be an unfavourable method for the less defective exfoliation and dispersion of layered materials. Here we show that judicious use of ultrasonic cavitation can produce exfoliated transition metal dichalcogenide nanosheets extraordinarily dispersed in non-toxic solvent by minimising the sonolysis of solvent molecules. Our method can also lead to produce less defective, large graphene oxide nanosheets from graphite oxide in a short time (within 10 min), which show high electrical conductivity (>20,000 S m−1) of the printed film. This was achieved by adjusting the ultrasonic probe depth to the liquid surface to generate less energetic cavitation (delivered power ~6 W), while maintaining sufficient acoustic shearing (0.73 m s−1) and generating additional microbubbling by aeration at the liquid surface. PMID:24875584

  3. Understanding acoustic cavitation for sonolytic degradation of p-cresol as a model contaminant.

    PubMed

    Balachandran, Rajesh; Patterson, Zach; Deymier, Pierre; Snyder, Shane A; Keswani, Manish

    2016-03-01

    Many modern techniques exist for the degradation of organic pollutants in water. Numerous treatment processes which utilize the formation of hydroxyl radicals for oxidation of pollutants have been studied thoroughly. In this study, a three pronged approach has been used to characterize and understand the effect of two distinct acoustic frequencies (37 kHz and 1 MHz) on cavitation behavior. Correlation of this behavior with sonolysis of a target phenol pollutant is described. Hydroxyl radical capture, hydrophone, and microelectrode studies in this work show that megasonic frequencies are more effective for generation of hydroxyl radicals and stable cavitation events than ultrasonic frequencies. UV absorption and fluorescence measurements confirm that the combination of ultrasonic sonolysis with a Fenton reagent achieved complete degradation of p-cresol at 50 mg/L in about 30 min. Cost estimates have been made for different sonication processes and compared with traditional advanced oxidation processes. PMID:26761597

  4. Chromatically encoded high-speed photography of cavitation bubble dynamics inside inhomogeneous ophthalmic tissue

    NASA Astrophysics Data System (ADS)

    Tinne, N.; Matthias, B.; Kranert, F.; Wetzel, C.; Krüger, A.; Ripken, T.

    2016-03-01

    The interaction effect of photodisruption, which is used for dissection of biological tissue with fs-laser pulses, has been intensively studied inside water as prevalent sample medium. In this case, the single effect is highly reproducible and, hence, the method of time-resolved photography is sufficiently applicable. In contrast, the reproducibility significantly decreases analyzing more solid and anisotropic media like biological tissue. Therefore, a high-speed photographic approach is necessary in this case. The presented study introduces a novel technique for high-speed photography based on the principle of chromatic encoding. For illumination of the region of interest within the sample medium, the light paths of up to 12 LEDs with various emission wavelengths are overlaid via optical filters. Here, MOSFET-electronics provide a LED flash with a duration <100 ns; the diodes are externally triggered with a distinct delay for every LED. Furthermore, the different illumination wavelengths are chromatically separated again for detection via camera chip. Thus, the experimental setup enables the generation of a time-sequence of <= 12 images of a single cavitation bubble dynamics. In comparison to conventional time-resolved photography, images in sample media like water and HEMA show the significant advantages of this novel illumination technique. In conclusion, the results of this study are of great importance for the fundamental evaluation of the laser-tissue interaction inside anisotropic biological tissue and for the optimization of the surgical process with high-repetition rate fs-lasers. Additionally, this application is also suitable for the investigation of other microscopic, ultra-fast events in transparent inhomogeneous materials.

  5. Cavitation bubble-driven cell and particle behavior in an ultrasound standing wave.

    PubMed

    Kuznetsova, Larisa A; Khanna, Sanjay; Amso, Nazar N; Coakley, W Terence; Doinikov, Alexander A

    2005-01-01

    The behavior of human erythrocytes and 1-microm-diameter fluorescent latex beads in the presence of Optison contrast agent in a single half-wavelength (lambda/2) ultrasound standing wave (USSW) resonator has been studied. The particle movements were observed with an epi-fluorescent microscope and the velocity of the particles and cells was measured by particle image velocimetry (PIV). Acoustic emissions were monitored with a microphone and a spectrum analyzer. Optison contrast agent disintegrated immediately on exposure to ultrasound of 0.98-MPa acoustic pressure amplitude or higher in a chamber driven at its resonance frequency of 1.56 MHz. A discrete cloud of active microbubbles, detected at the pressure node plane, disappeared gradually and was completely lost within 15 s. The microscopy showed three-dimensional regions of circulation of both 1-microm tracer particles and erythrocytes in planes perpendicular to the pressure node plane. A numerical simulation showed that, for parameters that conform to the experimental conditions, a bubble of a subresonance size moves towards and translates about a pressure node plane. This result is in agreement with the experimental observation that the particle and cell circulation is induced by the presence and/or translational motion of microbubbles at the pressure node plane. PMID:15704403

  6. Cavitations induced by plasmas, plasmas induced by cavitations, and plasmas produced in cavitations

    NASA Astrophysics Data System (ADS)

    Sasaki, Koichi

    2015-11-01

    Cavitation bubbles are not static bubbles but have dynamics of expansion, shrinkage, and collapse. Since the collapse of a cavitation bubble is roughly an adiabatic process, the inside of the bubble at the collapse has a high temperature and a high pressure, resulting in the production of a plasma. This talk will be focused on cavitation-related plasma phenomena and the role of the cavitation bubble in the synthesis of nanoparticles. A method for inducing a cavitation bubble is laser ablation in liquid. After the disappearance of laser-produced plasma with optical emission, we have observed the formation of a cavitation bubble. We have found that the inside of the cavitation bubble is the reaction field for the synthesis of nanoparticles. The atomic and molecular species ejected from the ablation target toward the liquid are transported into the cavitation bubble, and they condense into nanoparticles inside it. It is important to note that nanoparticles are stored inside the cavitation bubble until its collapse. We have shown that the size and the structure of nanoparticles are controlled by controlling the dynamics of the cavitation bubbles. Another method for inducing cavitation bubbles is to use ultrasonic power. We have found a simple method for the efficient production of standing cavitation bubbles. The method is just inserting a punching metal plate into water irradiated by ultrasonic wave. The depth of water and the position of the punching plate should be tuned precisely. We have proposed the mechanism of the efficient production of cavitation bubbles by this method. Currently, we try to have electric discharges in cavitation bubbles with the intention of realizing nonequilibrium sonochemistry. In particular, the electric discharge in a laser-induced cavitation bubble shows interesting distortion of the bubble shape, which suggests the electrostatic characteristics of the cavitation bubble.

  7. Controlled manipulation and in situ mechanical measurement of single co nanowire with a laser-induced cavitation bubble.

    PubMed

    Huang, Xiaohu; Quinto-Su, Pedro A; Gonzalez-Avila, S Roberto; Wu, Tom; Ohl, Claus-Dieter

    2010-10-13

    The flow induced by a single laser-induced cavitation bubble is used to manipulate individual Co nanowires. The short-lived (<20 μs) bubble with a maximum size of 45 μm is created in an aqueous solution with a laser pulse. Translation, rotation, and radial motion of the nanowire can be selectively achieved by varying the initial distance and orientation of the bubble with respect to the nanowire. Depending on the initial distance, the nanowire can be either pushed away or pulled toward the laser focus. No translation is observed for a distance further than approximately 60 μm, while at closer distance, the nanowire can be bent as a result of the fast flow induced during the bubble collapse. Studying the dynamics of the shape recovery allows an estimation of the Young's modulus of the nanowire. The low measured Young's modulus (in a range from 9.6 to 13.0 GPa) of the Co nanowire is attributed to a softening effect due to structural defects and surface oxidation layer. Our study suggests that this bubble-based technique allows selectively transporting, orienting, and probing individual nanowires and may be exploited for constructing functional nanodevices.

  8. Development of anticavitation hydrophone using a titanium front plate: Effect of the titanium front plate in high-intensity acoustic field with generation of acoustic cavitation

    NASA Astrophysics Data System (ADS)

    Shiiba, Michihisa; Okada, Nagaya; Kurosawa, Minoru; Takeuchi, Shinichi

    2016-07-01

    Novel anticavitation hydrophones were fabricated by depositing a hydrothermally synthesized lead zirconate titanate polycrystalline film at the back of a titanium front plate. These anticavitation hydrophones were not damaged by the measurement of the acoustic field formed by a high-intensity focused ultrasound (HIFU) device. Their sensitivity was improved by approximately 20 dB over that of the conventional anticavitation hydrophone by modifying their basic structure and materials. The durability of the anticavitation hydrophone that we fabricated was compared by exposing it to a high-intensity acoustic field at the focal point of the HIFU field and in the water tank of an ultrasound cleaner. Therefore, the effect of the surface of the titanium front plate on acoustic cavitation was investigated by exposing such a surface to the high-intensity acoustic field. We found that the fabricated anticavitation hydrophone was robust and was not damaged easily, even in the focused acoustic field where acoustic cavitation occurs.

  9. Effect of an entrained air bubble on the acoustics of an ink channel.

    PubMed

    Jeurissen, Roger; de Jong, Jos; Reinten, Hans; van den Berg, Marc; Wijshoff, Herman; Versluis, Michel; Lohse, Detlef

    2008-05-01

    Piezo-driven inkjet systems are very sensitive to air entrapment. The entrapped air bubbles grow by rectified diffusion in the ink channel and finally result in nozzle failure. Experimental results on the dynamics of fully grown air bubbles are presented. It is found that the bubble counteracts the pressure buildup necessary for the droplet formation. The channel acoustics and the air bubble dynamics are modeled. For good agreement with the experimental data it is crucial to include the confined geometry into the model: The air bubble acts back on the acoustic field in the channel and thus on its own dynamics. This two-way coupling limits further bubble growth and thus determines the saturation size of the bubble.

  10. Memory effect and redistribution of cavitation nuclei in a thin liquid layer.

    PubMed

    Bai, Lixin; Lin, Weijun; Wu, Pengfei; Deng, Jingjun; Li, Chao; Xu, Delong; Wang, Dong; Chen, Lishuo

    2016-09-01

    Temporal evolution and spatial distribution of acoustic cavitation structures in a thin liquid layer were investigated experimentally with high-speed photography. The inception and disappearance processes of cavitation bubble cloud revealed that the metastable cavitaton structures formed in the thin liquid layer caused a long-term "memory effect". A factor which weakens the memory effect was identified. The distribution of cavitation nuclei was investigated by changing the temporal decay of the memory effect. PMID:27150763

  11. Cavitation microjets as a contributory mechanism for renal calculi disintegration in ESWL.

    PubMed

    Crum, L A

    1988-12-01

    The rarefaction shock wave produced by an extracorporeal shockwave lithotripter can result in liquid failure at numerous discrete sites near the second focus. When the liquid fails, vapor-filled cavities can grow to relatively large sizes and subsequently collapse with enormous violence. This phenomenon, called acoustic cavitation, has been shown to cause severe erosion in materials exposed to cavitation fields. It is proposed in this paper that ESWL devices generate acoustic cavitation in vivo and that the high speed liquid microjets produced during cavitation bubble collapse play an important role in renal calculi disintegration.

  12. Acoustic bubble: Controlled and selective micropropulsion and chemical waveform generator

    NASA Astrophysics Data System (ADS)

    Ahmed, Daniel

    The physics governing swimming at the microscale---where viscous forces dominate over inertial---is distinctly different than that at the macroscale. Devices capable of finely controlled swimming at the microscale could enable bold ideas such as targeted drug delivery, non-invasive microsurgery, and precise materials assembly. Progress has already been made towards such artificial microswimmers using several means of actuation: chemical reactions and applied magnetic, electric or acoustic fields. However, the prevailing goal of selective actuation of a single microswimmer from within a group, the first step towards collaborative, guided action by a group of swimmers, has so far not been achieved. Here I present a new class of microswimmer that accomplishes for the first time selective actuation (Chapter 1). The swimmer design eschews the commonly-held design paradigm that microswimmers must use non-reciprocal motion to achieve propulsion; instead, the swimmer is propelled by oscillatory motion of an air bubble trapped within the swimmer's polymer body. This oscillatory motion is driven by a low-power biocompatible acoustic field to the ambient liquid, with meaningful swimmer propulsion occurring only at resonance frequencies of the bubble. This acoustically-powered microswimmer performs controllable rapid translational and rotational motion even in highly viscous liquid. By using a group of swimmers each with a different bubble size (and thus different resonance frequencies) selective actuation of a single swimmer from among the group can be readily achieved. Cellular response to chemical microenvironments depends on the spatiotemporal characteristics of the stimulus, which is central to many biological processes including gene expression, cell migration, differentiation, apoptosis, and intercellular signaling. To date, studies have been limited to digital (or step) chemical stimulation with little control over the temporal counterparts. Microfluidic approaches

  13. Small Gas Bubble Experiment for Mitigation of Cavitation Damage and Pressure Waves in Short-pulse Mercury Spallation Targets

    SciTech Connect

    Wendel, Mark W; Felde, David K; Sangrey, Robert L; Abdou, Ashraf A; West, David L; Shea, Thomas J; Hasegawa, Shoichi; Kogawa, Hiroyuki; Naoe, Dr. Takashi; Farny, Dr. Caleb H.; Kaminsky, Andrew L

    2014-01-01

    Populations of small helium gas bubbles were introduced into a flowing mercury experiment test loop to evaluate mitigation of beam-pulse induced cavitation damage and pressure waves. The test loop was developed and thoroughly tested at the Spallation Neutron Source (SNS) prior to irradiations at the Los Alamos Neutron Science Center - Weapons Neutron Research Center (LANSCE-WNR) facility. Twelve candidate bubblers were evaluated over a range of mercury flow and gas injection rates by use of a novel optical measurement technique that accurately assessed the generated bubble size distributions. Final selection for irradiation testing included two variations of a swirl bubbler provided by Japan Proton Accelerator Research Complex (J-PARC) collaborators and one orifice bubbler developed at SNS. Bubble populations of interest consisted of sizes up to 150 m in radius with achieved gas void fractions in the 10^-5 to 10^-4 range. The nominal WNR beam pulse used for the experiment created energy deposition in the mercury comparable to SNS pulses operating at 2.5 MW. Nineteen test conditions were completed each with 100 pulses, including variations on mercury flow, gas injection and protons per pulse. The principal measure of cavitation damage mitigation was surface damage assessment on test specimens that were manually replaced for each test condition. Damage assessment was done after radiation decay and decontamination by optical and laser profiling microscopy with damaged area fraction and maximum pit depth being the more valued results. Damage was reduced by flow alone; the best mitigation from bubble injection was between half and a quarter that of flow alone. Other data collected included surface motion tracking by three laser Doppler vibrometers (LDV), loop wall dynamic strain, beam diagnostics for charge and beam profile assessment, embedded hydrophones and pressure sensors, and sound measurement by a suite of conventional and contact microphones.

  14. Transcranial Assessment and Visualization of Acoustic Cavitation: Modeling and Experimental Validation

    PubMed Central

    Clement, Gregory T.; McDannold, Nathan

    2015-01-01

    The interaction of ultrasonically-controlled microbubble oscillations (acoustic cavitation) with tissues and biological media has been shown to induce a wide range of bioeffects that may have significant impact to therapy and diagnosis of central nervous system diseases and disorders. However, the inherently non-linear microbubble oscillations combined with the micrometer and microsecond scales involved in these interactions and the limited methods to assess and visualize them transcranially hinder both their optimal use and translation to the clinics. To overcome these challenges, we present a noninvasive and clinically relevant framework that combines numerical simulations with multimodality imaging to assess and visualize the microbubble oscillations transcranially. In the present work, acoustic cavitation was studied with an integrated US and MR imaging guided clinical FUS system in non-human primates. This multimodality imaging system allowed us to concurrently induce and visualize acoustic cavitation transcranially. A high-resolution brain CT-scan that allowed us to determine the head acoustic properties (density, speed of sound, and absorption) was also co-registered to the US and MR images. The derived acoustic properties and the location of the targets that were determined by the 3D-CT scans and the post sonication MRI respectively were then used as inputs to two-and three-dimensional Finite Difference Time Domain (2D, 3D-FDTD) simulations that matched the experimental conditions and geometry. At the experimentally-determined target locations, synthetic point sources with pressure amplitude traces derived by either a Gaussian function or the output of a microbubble dynamics model were numerically excited and propagated through the skull towards a virtual US imaging array. Then, using passive acoustic mapping that was refined to incorporate variable speed of sound, we assessed the losses and aberrations induced by the skull as a function of the acoustic

  15. Clustering reveals cavitation-related acoustic emission signals from dehydrating branches.

    PubMed

    Vergeynst, Lidewei L; Sause, Markus G R; De Baerdemaeker, Niels J F; De Roo, Linus; Steppe, Kathy

    2016-06-01

    The formation of air emboli in the xylem during drought is one of the key processes leading to plant mortality due to loss in hydraulic conductivity, and strongly fuels the interest in quantifying vulnerability to cavitation. The acoustic emission (AE) technique can be used to measure hydraulic conductivity losses and construct vulnerability curves. For years, it has been believed that all the AE signals are produced by the formation of gas emboli in the xylem sap under tension. More recent experiments, however, demonstrate that gas emboli formation cannot explain all the signals detected during drought, suggesting that different sources of AE exist. This complicates the use of the AE technique to measure emboli formation in plants. We therefore analysed AE waveforms measured on branches of grapevine (Vitis vinifera L. 'Chardonnay') during bench dehydration with broadband sensors, and applied an automated clustering algorithm in order to find natural clusters of AE signals. We used AE features and AE activity patterns during consecutive dehydration phases to identify the different AE sources. Based on the frequency spectrum of the signals, we distinguished three different types of AE signals, of which the frequency cluster with high 100-200 kHz frequency content was strongly correlated with cavitation. Our results indicate that cavitation-related AE signals can be filtered from other AE sources, which presents a promising avenue into quantifying xylem embolism in plants in laboratory and field conditions. PMID:27095256

  16. Modeling bubble dynamics and radical kinetics in ultrasound induced microalgal cell disruption.

    PubMed

    Wang, Meng; Yuan, Wenqiao

    2016-01-01

    Microalgal cell disruption induced by acoustic cavitation was simulated through solving the bubble dynamics in an acoustical field and their radial kinetics (chemical kinetics of radical species) occurring in the bubble during its oscillation, as well as calculating the bubble wall pressure at the collapse point. Modeling results indicated that increasing ultrasonic intensity led to a substantial increase in the number of bubbles formed during acoustic cavitation, however, the pressure generated when the bubbles collapsed decreased. Therefore, cumulative collapse pressure (CCP) of bubbles was used to quantify acoustic disruption of a freshwater alga, Scenedesmus dimorphus, and a marine alga, Nannochloropsis oculata and compare with experimental results. The strong correlations between CCP and the intracellular lipid fluorescence density, chlorophyll-a fluorescence density, and cell particle/debris concentration were found, which suggests that the developed models could accurately predict acoustic cell disruption, and can be utilized in the scale up and optimization of the process. PMID:26384877

  17. Acoustic studies for alpha background rejection in dark matter bubble chamber detectors

    SciTech Connect

    Bou-Cabo, M.; Felis, I.; Ardid, M.; Collaboration: COUPP Collaboration

    2013-08-08

    COUPP (Chicagoland Observatory for Underground Particle Physics) is an experiment with bubble chambers able to detect dark matter directly either with Spin-Dependent or with Spin-Independent interactions. The target material is a superheated liquid (usually CF3I) that can be bubble nucleated due to nuclear recoils produced by elastic collisions of dark matter particles. The bubble growth inside the chamber is accompanied with an acoustic signature. The acoustic technique has been successfully used to have a good alpha discrimination (about 99%). In this paper, we present different studies and results related with the characterization of the acoustic properties of the detector and the different phenomena involved in the acoustic measurements of the bubble growth, such as sound generation, sound transmission and optimization of piezoelectric transducers.

  18. Bubble-Based Acoustic Radiation Force Using Chirp Insonation to Reduce Standing Wave Effects

    PubMed Central

    Erpelding, Todd N.; Hollman, Kyle W.; O’Donnell, Matthew

    2007-01-01

    Bubble-based acoustic radiation force can measure local viscoelastic properties of tissue. High intensity acoustic waves applied to laser-generated bubbles induce displacements inversely proportional to local Young’s modulus. In certain instances, long pulse durations are desirable but are susceptible to standing wave artifacts, which corrupt displacement measurements. Chirp pulse acoustic radiation force was investigated as a method to reduce standing wave artifacts. Chirp pulses with linear frequency sweep magnitudes of 100, 200, and 300 kHz centered around 1.5 MHz were applied to glass beads within gelatin phantoms and laser-generated bubbles within porcine lenses. The ultrasound transducer was translated axially to vary standing wave conditions, while comparing displacements using chirp pulses and 1.5 MHz tone burst pulses of the same duration and peak rarefactional pressure. Results demonstrated significant reduction in standing wave effects using chirp pulses, with displacement proportional to acoustic intensity and bubble size. PMID:17306697

  19. Nuclei and propeller cavitation inception

    SciTech Connect

    Gindroz, B.; Billet, M.L.

    1994-12-31

    Propeller cavitation inception tests were conducted in the Grand Tunnel Hydrodynamique (GTH) of the Bassin d`Essaid des Carenes. Both acoustic and visual cavitation inception were determined for leading-edge sheet, travelling bubble, and tip vortex. These data were obtained for specific water quality conditions. The water quality was determined from cavitation susceptibility meter measurements for degassed water (maximum liquid tension, few nuclei), low injection rate of microbubbles (medium liquid tension, low nuclei concentration), medium injection rate of microbubbles (medium liquid tension, high nuclei concentration) and high injection rate of microbubbles (minimum liquid tension, high nuclei concentration). Results clearly demonstrate a different influence of water quality for each type of cavitation. Little variation in cavitation inception index for a significant increase in liquid tension and microbubble size distribution was found for leading-edge sheet; however, tip vortex cavitation inception index decreased significantly for an increase in liquid tension. In addition, a dependency on event rate was determined for tip vortex cavitation inception.

  20. Observations of clustering inside oceanic bubble clouds and the effect on short-range acoustic propagation.

    PubMed

    Weber, Thomas C

    2008-11-01

    It has recently been shown [Weber, T. C. et al. (2007). "Acoustic propagation through clustered bubble clouds," IEEE J. Ocean. Eng. 32, 513-523] that gas bubble clustering plays a role in determining the acoustic field characteristics of bubbly fluids. In particular, it has been shown that clustering changes the bubble-induced attenuation as well as the ping-to-ping variability in the acoustic field. The degree to which bubble clustering exists in nature, however, is unknown. This paper describes a method for quantifying bubble clustering using a high frequency (400 kHz) multibeam sonar, and reports on observations of near-surface bubble clustering during a storm (14.6 m/s wind speed) in the Gulf of Maine. The multibeam sonar data are analyzed to estimate the pair correlation function, a measure of bubble clustering. In order to account for clustering in the mean acoustic field, a modification to the effective medium wave number is made. With this modification, the multibeam sonar observations are used to predict the effect of clustering on the attenuation of the mean field for short-range propagation (1 m) at frequencies between 10 and 350 kHz. Results for this specific case show that clustering can cause the attenuation to change by 20%-80% over this frequency range.

  1. Observations of clustering inside oceanic bubble clouds and the effect on short-range acoustic propagation.

    PubMed

    Weber, Thomas C

    2008-11-01

    It has recently been shown [Weber, T. C. et al. (2007). "Acoustic propagation through clustered bubble clouds," IEEE J. Ocean. Eng. 32, 513-523] that gas bubble clustering plays a role in determining the acoustic field characteristics of bubbly fluids. In particular, it has been shown that clustering changes the bubble-induced attenuation as well as the ping-to-ping variability in the acoustic field. The degree to which bubble clustering exists in nature, however, is unknown. This paper describes a method for quantifying bubble clustering using a high frequency (400 kHz) multibeam sonar, and reports on observations of near-surface bubble clustering during a storm (14.6 m/s wind speed) in the Gulf of Maine. The multibeam sonar data are analyzed to estimate the pair correlation function, a measure of bubble clustering. In order to account for clustering in the mean acoustic field, a modification to the effective medium wave number is made. With this modification, the multibeam sonar observations are used to predict the effect of clustering on the attenuation of the mean field for short-range propagation (1 m) at frequencies between 10 and 350 kHz. Results for this specific case show that clustering can cause the attenuation to change by 20%-80% over this frequency range. PMID:19045766

  2. Enhanced delivery of gold nanoparticles by acoustic cavitation for photoacoustic imaging and photothermal therapy

    NASA Astrophysics Data System (ADS)

    Wang, Yu-Hsin; Liao, Ai-Ho; Lin, Jia-Yu; Lee, Cheng-Ru; Wu, Cheng-Ham; Liu, Tzu-Min; Wang, Churng-Ren; Li, Pai-Chi

    2013-03-01

    Gold-nanorods incorporated with microbubbles (AuMBs) were introduced as a photoacoustic/ultrasound dual- modality contrast agent in our previous study. The application can be extended to theragnosis purpose. With the unique physical characteristics of AuMBs, we propose an enhanced delivery method for the encapsulated particles. For example, laser thermotherapy mediated by plasmonic nanoparticles can be made more effective by using microbubbles as a targeted carrier and acoustic cavitation for enhanced sonoporation. The hypothesis was experimentally tested. Firts, these AuMBs first act as molecular probes with binding to specific ligands. The improved targeting efficacy was macroscopically observed by an ultrasound system. The extended retention of targeted AuMB was observed and recorded for 30 minutes in a CT-26 tumor bearing mouse. Secondly, cavitation induced by time-varying acoustic field was also applied to disrupt the microbubbles and cause increased transient cellular permeability (a.k.a., sonoporation). Multimodal optical microscope based on a Cr:forsterite laser was used to directly observe these effects. The microscope can acquired third-harmonic generation (THG) and two-photon fluorescent (2PF) signals produced by the AuMBs. In vitro examination shows approximately a 60% improvement in terms of fluorescence signals from the cellular uptake of gold nanoparticles after sonoporation treatment. Therefore, we conclude that the controlled release is feasible and can further improve the therapeutic effects of the nanoparticles.

  3. Acoustic Droplet Vaporization, Cavitation, and Therapeutic Properties of Copolymer-Stabilized Perfluorocarbon Nanoemulsions

    SciTech Connect

    Nam, Kweon-Ho; Christensen, Douglas A.; Rapoport, Natalya; Kennedy, Anne M.

    2009-04-14

    Acoustic and therapeutic properties of Doxorubicin (DOX) and paclitaxel (PTX)-loaded perfluorocarbon nanoemulsions have been investigated in a mouse model of ovarian cancer. The nanoemulsions were stabilized by two biodegradable amphiphilic block copolymers that differed in the structure of the hydrophobic block. Acoustic droplet vaporization (ADV) and cavitation parameters were measured as a function of ultrasound frequency, pressure, duty cycles, and temperature. The optimal parameters that induced ADV and inertial cavitation of the formed microbubbles were used in vivo in the experiments on the ultrasound-mediated chemotherapy of ovarian cancer. A combination tumor treatment by intravenous injections of drug-loaded perfluoropentane nanoemulsions and tumor-directed 1-MHz ultrasound resulted in a dramatic decrease of ovarian or breast carcinoma tumor volume and sometimes complete tumor resolution. However, tumors often recurred three to six weeks after the treatment indicating that some cancer cells survived the treatment. The recurrent tumors proved more aggressive and resistant to the repeated therapy than initial tumors suggesting selection for the resistant cells during the first treatment.

  4. Condition of resonant break-up of gas bubbles by an acoustic wave in liquid

    NASA Astrophysics Data System (ADS)

    Vanovskiy, V. V.; Petrov, A. G.

    2016-07-01

    The linear theory of damping of radial vibrations of a bubble in a liquid is constructed by taking into account the key dissipative mechanisms: thermal, viscous, and acoustic. The basic approximation of homobaricity made helps to obtain the results in a convenient and simple form. The results obtained for damping are used further in the description of the forced resonant oscillations of a bubble in an acoustic wave with the frequency equal to the eigenfrequency of the radial oscillation mode and twice as high as the frequency of the deformation oscillation mode (resonance 2:2:1). It is shown that the amplitude of deformation oscillations, which is reasonably large for breaking, is developed at a relatively small pressure amplitude of the exciting acoustic wave, and subharmonics arise in the acoustic-emission spectrum. The condition of bubble break-up is obtained for a fast and slow start of the acoustic wave.

  5. Aspherical bubble dynamics and oscillation times

    SciTech Connect

    Vogel, A.; Noack, J.; Chapyak, E.J.; Godwin, R.P.

    1999-06-01

    The cavitation bubbles common in laser medicine are rarely perfectly spherical and are often located near tissue boundaries, in vessels, etc., which introduce aspherical dynamics. Here, novel features of aspherical bubble dynamics are explored by time-resolved photography and numerical simulations. The growth-collapse period of cylindrical bubbles of large aspect ratio (length:diameter {approximately}20) differs only slightly from twice the Rayleigh collapse time for a spherical bubble with an equivalent maximum volume. This fact justifies using the temporal interval between the acoustic signals emitted upon bubble creation and collapse to estimate the maximum bubble volume. As a result, hydrophone measurements can provide an estimate of the bubble size and energy even for aspherical bubbles. The change of the oscillation period of bubbles near solid walls and elastic (tissue-like) boundaries relative to that of isolated spherical bubbles is also investigated.

  6. High-speed observation of bubble cloud generation near a rigid wall by second-harmonic superimposed ultrasound.

    PubMed

    Yoshizawa, Shin; Yasuda, Jun; Umemura, Shin-ichiro

    2013-08-01

    Cavitation bubbles are known to accelerate therapeutic effects of ultrasound. Although negative acoustic pressure is the principle factor of cavitation, positive acoustic pressure has a role for bubble cloud formation at a high intensity of focused ultrasound when cavitation bubbles provide pressure release surfaces converting the pressure from highly positive to negative. In this study, the second-harmonic was superimposed onto the fundamental acoustic pressure to emphasize either peak positive or negative pressure. The peak negative and positive pressure emphasized waves were focused on a surface of an aluminum block. Cavitation bubbles induced near the block were observed with a high-speed camera by backlight and the size of the cavitation generation region was measured from the high-speed images. The negative pressure emphasized waves showed an advantage in cavitation inception over the positive pressure emphasized waves. In the sequence of the negative pressure emphasized waves immediately followed by the positive pressure emphasized waves, cavitation bubbles were generated on the block by the former waves and the cavitation region were expanded toward the transducer in the latter waves with high reproducibility. The sequence demonstrated its potential usefulness in enhancing the effects of therapeutic ultrasound at a high acoustic intensity.

  7. Bubble Combustion

    NASA Technical Reports Server (NTRS)

    Corrigan, Jackie

    2004-01-01

    A method of energy production that is capable of low pollutant emissions is fundamental to one of the four pillars of NASA s Aeronautics Blueprint: Revolutionary Vehicles. Bubble combustion, a new engine technology currently being developed at Glenn Research Center promises to provide low emissions combustion in support of NASA s vision under the Emissions Element because it generates power, while minimizing the production of carbon dioxide (CO2) and nitrous oxides (NOx), both known to be Greenhouse gases. and allows the use of alternative fuels such as corn oil, low-grade fuels, and even used motor oil. Bubble combustion is analogous to the inverse of spray combustion: the difference between bubble and spray combustion is that spray combustion is spraying a liquid in to a gas to form droplets, whereas bubble combustion involves injecting a gas into a liquid to form gaseous bubbles. In bubble combustion, the process for the ignition of the bubbles takes place on a time scale of less than a nanosecond and begins with acoustic waves perturbing each bubble. This perturbation causes the local pressure to drop below the vapor pressure of the liquid thus producing cavitation in which the bubble diameter grows, and upon reversal of the oscillating pressure field, the bubble then collapses rapidly with the aid of the high surface tension forces acting on the wall of the bubble. The rapid and violent collapse causes the temperatures inside the bubbles to soar as a result of adiabatic heating. As the temperatures rise, the gaseous contents of the bubble ignite with the bubble itself serving as its own combustion chamber. After ignition, this is the time in the bubble s life cycle where power is generated, and CO2, and NOx among other species, are produced. However, the pollutants CO2 and NOx are absorbed into the surrounding liquid. The importance of bubble combustion is that it generates power using a simple and compact device. We conducted a parametric study using CAVCHEM

  8. Contributions to the acoustic excitation of bubbles released from a nozzle.

    PubMed

    Czerski, Helen; Deane, Grant B

    2010-11-01

    It has recently been demonstrated that air bubbles released from a nozzle are excited into volume mode oscillations by the collapse of the neck of air formed at the moment of bubble detachment. A pulse of sound is caused by these breathing mode oscillations, and the sound of air-entraining flows is made up of many such pulses emitted as bubbles are created. This paper is an elaboration on a JASA-EL paper, which examined the acoustical excitation of bubbles released from a nozzle. Here, further details of the collapse of a neck of air formed at the moment of bubble formation and its implications for the emission of sound by newly formed bubbles are presented. The role of fluid surface tension was studied using high-speed photography and found to be consistent with a simple model for neck collapse. A re-entrant fluid jet forms inside the bubble just after detachment, and its role in acoustic excitation is assessed. It is found that for slowly-grown bubbles the jet does make a noticeable difference to the total volume decrease during neck collapse, but that it is not a dominant effect in the overall acoustic excitation. PMID:21110560

  9. Instability of sonoluminescing bubbles under a nonspherical symmetrical acoustic-pressure perturbation.

    PubMed

    An, Yu; Lu, Tao; Yang, Bing

    2005-02-01

    The perturbation of nonspherical symmetrical acoustic pressure is added to the equation governing the spherical stability of sonoluminescing bubbles. The numerical calculations of the shape instability of sonoluminescing bubbles with the modified equation are conducted and the results are illustrated accordingly in the p(a) - R0 phase diagrams. The calculated results indicate that the stability region vanishes as the amplitude of the driving acoustic pressure p(a) arrives at the upper threshold ( approximately 1.6 atm) due to the perturbation of a small nonspherical symmetrical acoustic pressure (about a few Pa), which is in consistence with the experimental observations.

  10. Gas flow induced by ultrasonic cavitation bubble clouds and surface capillary wave.

    PubMed

    Wang, Ying; Li, Tao; Kong, Ling Bing; Hng, Huey Hoon; Lee, Pooi See

    2014-06-01

    In this paper, we report a gas flow phenomenon induced by ultrasonic water cavitation and capillary wave in a vibrating hollow tip and reflector system. The cavitation clouds generated a gas suction force and the capillary wave created tunnels through which the gas could go into the liquid. The gas flow rate was measured and compared under different conditions, including applied power, type of reflector, and tip-to-reflector distance. A model was proposed to explain the mechanisms of the gas flow and analyze the results in the experiments.

  11. Regulating Ultrasound Cavitation in order to Induce Reproducible Sonoporation

    NASA Astrophysics Data System (ADS)

    Mestas, J.-L.; Alberti, L.; El Maalouf, J.; Béra, J.-C.; Gilles, B.

    2010-03-01

    Sonoporation would be linked to cavitation, which generally appears to be a non reproducible and unstationary phenomenon. In order to obtain an acceptable trade-off between cell mortality and transfection, a regulated cavitation generator based on an acoustical cavitation measurement was developed and tested. The medium to be sonicated is placed in a sample tray. This tray is immersed in in degassed water and positioned above the face of a flat ultrasonic transducer (frequency: 445 kHz; intensity range: 0.08-1.09 W/cm2). This technical configuration was admitted to be conducive to standing-wave generation through reflection at the air/medium interface in the well thus enhancing the cavitation phenomenon. Laterally to the transducer, a homemade hydrophone was oriented to receive the acoustical signal from the bubbles. From this spectral signal recorded at intervals of 5 ms, a cavitation index was calculated as the mean of the cavitation spectrum integration in a logarithmic scale, and the excitation power is automatically corrected. The device generates stable and reproducible cavitation level for a wide range of cavitation setpoint from stable cavitation condition up to full-developed inertial cavitation. For the ultrasound intensity range used, the time delay of the response is lower than 200 ms. The cavitation regulation device was evaluated in terms of chemical bubble collapse effect. Hydroxyl radical production was measured on terephthalic acid solutions. In open loop, the results present a great variability whatever the excitation power. On the contrary the closed loop allows a great reproducibility. This device was implemented for study of sonodynamic effect. The regulation provides more reproducible results independent of cell medium and experimental conditions (temperature, pressure). Other applications of this regulated cavitation device concern internalization of different particles (Quantum Dot) molecules (SiRNA) or plasmids (GFP, DsRed) into different

  12. Efficient generation of cavitation bubbles and reactive oxygen species using triggered high-intensity focused ultrasound sequence for sonodynamic treatment

    NASA Astrophysics Data System (ADS)

    Yasuda, Jun; Yoshizawa, Shin; Umemura, Shin-ichiro

    2016-07-01

    Sonodynamic treatment is a method of treating cancer using reactive oxygen species (ROS) generated by cavitation bubbles in collaboration with a sonosensitizer at a target tissue. In this treatment method, both localized ROS generation and ROS generation with high efficiency are important. In this study, a triggered high-intensity focused ultrasound (HIFU) sequence, which consists of a short, extremely high intensity pulse immediately followed by a long, moderate-intensity burst, was employed for the efficient generation of ROS. In experiments, a solution sealed in a chamber was exposed to a triggered HIFU sequence. Then, the distribution of generated ROS was observed by the luminol reaction, and the amount of generated ROS was quantified using KI method. As a result, the localized ROS generation was demonstrated by light emission from the luminol reaction. Moreover, it was demonstrated that the triggered HIFU sequence has higher efficiency of ROS generation by both the KI method and the luminol reaction emission.

  13. Exploiting flow to control the in vitro spatiotemporal distribution of microbubble-seeded acoustic cavitation activity in ultrasound therapy

    NASA Astrophysics Data System (ADS)

    Pouliopoulos, Antonios N.; Bonaccorsi, Simone; Choi, James J.

    2014-11-01

    Focused ultrasound and microbubbles have been extensively used to generate therapeutic bioeffects. Despite encouraging in vivo results, there remains poor control of the magnitude and spatial distribution of these bioeffects due to the limited ability of conventional pulse shapes and sequences to control cavitation dynamics. Thus current techniques are restricted by an efficacy-safety trade-off. The primary aim of the present study was to incorporate the presence of flow in the design of new short pulse sequences, which can more uniformly distribute the cavitation activity. Microbubbles flowing (fluid velocity: 10 mm s-1) through a 300 μm tube were sonicated with a focused 0.5 MHz transducer while acoustic emissions were captured with an inserted focused 7.5 MHz passive cavitation detector. The two foci were co-axially aligned and their focal points were overlapped. Whereas conventional sequences are composed of a long burst (>10 000 cycles) emitted at a low burst repetition frequency (<10 Hz), we decomposed this burst into short pulses by adding intervals to facilitate inter-pulse microbubble movement. To evaluate how this sequence influenced cavitation distribution, we emitted short pulses (peak-rarefactional pressure (PRP): 40-366 kPa, pulse length (PL): 5-25 cycles) at high pulse repetition frequencies (PRF: 0.625-10 kHz) for a burst length of 100 ms. Increased cavitation persistence, implied by the duration of the microbubble acoustic emissions, was a measure of improved distribution due to the presence of flow. Sonication at lower acoustic pressures, longer pulse intervals and lower PLs improved the spatial distribution of cavitation. Furthermore, spectral analysis of the microbubble emissions revealed that the improvement at low pressures is due to persisting stable cavitation. In conclusion, new short-pulse sequences were shown to improve spatiotemporal control of acoustic cavitation dynamics during physiologically relevant flow. This

  14. Study of the Cavitation Region and the Evolution of the Acoustic Spectrum

    NASA Astrophysics Data System (ADS)

    Alekseev, V. N.; Andreev, V. G.; Romanenko, G. A.; Rybak, S. A.

    2001-07-01

    An experimental setup and a technique for measuring the transient period before a stationary cavitation in a liquid by the evolution of the cavitation noise spectrum are described. The time dependences of harmonic amplitudes both near the radiator and outside the cavitation region are presented. From the form of these dependences, the characteristic transient periods preceding the stage of a fully developed cavitation in water and in transformer oil are calculated. A formal scheme for describing the cavitation region is proposed.

  15. Evaluation and interpretation of bubble size distributions in pulsed megasonic fields

    NASA Astrophysics Data System (ADS)

    Hauptmann, M.; Struyf, H.; De Gendt, S.; Glorieux, C.; Brems, S.

    2013-05-01

    The occurrence of acoustic cavitation is incorporating a multitude of interdependent effects that strongly depend on the bubble size. Therefore, bubble size control would be beneficial for biological and industrial processes that rely on acoustic cavitation. A pulsed acoustic field can result in bubble size control and the repeated dissolution and reactivation ("recycling") of potentially active bubbles. As a consequence, a pulsed field can strongly enhance cavitation activity. In this paper, we present a modified methodology for the evaluation of the active bubble size distribution by means of a combination of cavitation noise measurements and ultrasonic pulsing. The key component of this modified methodology is the definition of an upper size limit, below which bubbles—in between subsequent pulses—have to dissolve, in order to be sustainably recycled. This upper limit makes it possible to explain and link the enhancement of cavitation activity to a bubble size distribution. The experimentally determined bubble size distributions for different power densities are interpreted in the frame of numerical calculations of the oscillatory responses of the bubbles to the intermittent driving sound field. The distributions are found to be shaped by the size dependent interplay between bubble pulsations, rectified diffusion, coalescence, and the development of parametrically amplified shape instabilities. Also, a phenomenological reactivation-deactivation model is proposed to explain and quantify the observed enhancement of cavitation activity under pulsed, with respect to continuous sonication. In this model, the pulse-duration determines the magnitude of the reactivation of partially dissolved bubbles and the deactivation of activated bubbles by coalescence. It is shown that the subsequent recycling of previously active bubbles leads to an accumulation of cavitation activity, which saturates after a certain number of pulses. The model is fitted to the experimental

  16. The behavior of acoustic bubbles in aqueous solutions containing soluble polymers.

    PubMed

    Tronson, Rohan; Tchea, Michelle F; Ashokkumar, Muthupandian; Grieser, Franz

    2012-11-26

    The effects of the water-soluble polymer polyvinylpyrrolidone (PVP) on the multibubble sonoluminescence (MBSL) intensity generated in aqueous solutions exposed to ultrasound at the two ultrasound frequencies of 20 and 363 kHz have been examined. In both cases, the presence of PVP, at concentrations of up to 2 g/100 mL, was found to enhance the MBSL intensity emitted from the solutions. On the basis of the intensity behavior of the SL observed from aqueous solutions containing PVP/surfactant and PVP/alcohol mixtures, it is suggested that PVP enhances MBSL by increasing the number of active bubbles in the system by hindering bubble-bubble coalescence processes and probably also by changing the structure of the bubble "clouds" formed at the acoustic antinodes in solution. The influence of PVP on bubble-bubble coalescence rates was also measured to support the interpretation of the MBSL emission experiments.

  17. Nonlinear activity of acoustically driven gas bubble near a rigid boundary

    SciTech Connect

    Maksimov, Alexey

    2015-10-28

    The presence of a boundary can produce considerable changes in the oscillation amplitude of the bubble and its scattered echo. The present study fills a gap in the literature, in that it is concerned theoretically with the bubble activity at relatively small distances from the rigid boundary. It was shown that the bi-spherical coordinates provide separation of variables and are more suitable for analysis of the dynamics of these constrained bubbles. Explicit formulas have been derived which describe the dependence of the bubble emission near a rigid wall on its size and the separation distance between the bubble and the boundary. As applications, time reversal technique for gas leakage detection and radiation forces that are induced by an acoustic wave on a constrained bubble were analyzed.

  18. Implosion of an underwater spark-generated bubble and acoustic energy evaluation using the Rayleigh model.

    PubMed

    Buogo, Silvano; Cannelli, Giovanni B

    2002-06-01

    The growth, collapse, and rebound of a vapor bubble generated by an underwater spark is studied by means of high-speed cinematography, simultaneously acquiring the emitted acoustic signature. Video recordings show that the growth and collapse phases are nearly symmetrical during the first two or three cycles, the bubble shape being approximately spherical. After 2-3 cycles the bubble behavior changes from a collapsing/rebounding regime with sound-emitting implosions to a pulsating regime with no implosions. The motion of the bubble wall during the first collapses was found to be consistent with the Rayleigh model of a cavity in an incompressible liquid, with the inclusion of a vapor pressure term at constant temperature within each bubble cycle. An estimate of the pressure inside the bubble is obtained measuring the collapse time and maximum radius, and the amount of energy converted into acoustical energy upon each implosion is deduced. The resulting value of acoustic efficiency was found to be in agreement with measurements based on the emitted acoustic pulse.

  19. Implosion of an underwater spark-generated bubble and acoustic energy evaluation using the Rayleigh model.

    PubMed

    Buogo, Silvano; Cannelli, Giovanni B

    2002-06-01

    The growth, collapse, and rebound of a vapor bubble generated by an underwater spark is studied by means of high-speed cinematography, simultaneously acquiring the emitted acoustic signature. Video recordings show that the growth and collapse phases are nearly symmetrical during the first two or three cycles, the bubble shape being approximately spherical. After 2-3 cycles the bubble behavior changes from a collapsing/rebounding regime with sound-emitting implosions to a pulsating regime with no implosions. The motion of the bubble wall during the first collapses was found to be consistent with the Rayleigh model of a cavity in an incompressible liquid, with the inclusion of a vapor pressure term at constant temperature within each bubble cycle. An estimate of the pressure inside the bubble is obtained measuring the collapse time and maximum radius, and the amount of energy converted into acoustical energy upon each implosion is deduced. The resulting value of acoustic efficiency was found to be in agreement with measurements based on the emitted acoustic pulse. PMID:12083190

  20. Shadowgraph Imaging and Numerical Simulation of Cavitation Bubbles Formed in Pulsed Laser Ablation Plasmas in the Vicinity of the Critical Point of CO2

    NASA Astrophysics Data System (ADS)

    Muneoka, Hitoshi; Himeno, Shohei; Urabe, Keiichiro; Stauss, Sven; Baba, Motoyoshi; Suemoto, Tohru; Terashima, Kazuo

    2015-09-01

    The characteristic behavior of cavitation bubbles formed in pulsed laser ablation plasmas in supercritical CO2 were investigated by shadowgraph imaging and numerical simulations. The time evolution of the cavitation bubbles could be divided into three phases near the critical point: Expansion, Double layer formation, and Contraction. The distribution of the refractive index was estimated from the variation of the direction of the refracted light in the shockwave in the expansion phase. It was suggested that the cause of the reduction of the transmitted light in the outer shell in the double-layer phase was not due to refraction, and the contributions of nanoparticles and clusters generated in supercritical fluids were implied. The characteristics in time evolution of the bubble size in the contraction phase, in particular almost constant position of the interface in a relatively long time, was proposed to be due to zero surface tension by numerical simulations. The results suggest that the properties and fluid structure peculiar to SCF affect the structure of cavitation bubbles.

  1. Toward the development of erosion-free ultrasonic cavitation cleaning with gas-supersaturated water

    NASA Astrophysics Data System (ADS)

    Yamashita, Tatsuya; Ando, Keita

    2015-11-01

    In ultrasonic cleaning, contaminant particles attached at target surfaces are removed by liquid flow or acoustic waves that are induced by acoustic cavitation bubbles. However, the inertial collapse of such bubbles often involve strong shock emission or water hammer by re-entrant jets, thereby giving rise to material erosion. Here, we aim at developing an erosion-free ultrasonic cleaning technique with the aid of gas-supersaturated water. The key idea is that (gaseous) cavitation is triggered easily even with low-intensity sonication in water where gases are dissolved beyond Henry's saturation limit, allowing us to buffer violent bubble collapse. In this presentation, we report on observations of the removal of micron/submicron-sized particles attached at glass surfaces by the action of gaseous cavitation bubbles under low-intensity sonication.

  2. Probability of cavitation for single ultrasound pulses applied to tissues and tissue-mimicking materials

    PubMed Central

    Maxwell, Adam D.; Cain, Charles A.; Hall, Timothy L.; Fowlkes, J. Brian; Xu, Zhen

    2012-01-01

    In this article, the negative pressure values at which inertial cavitation consistently occurs in response to a single, 2-cycle, focused ultrasound pulse were measured in several media relevant to cavitation-based ultrasound therapy. The pulse was focused into a chamber containing one of the media, which included liquids, tissue-mimicking materials, and ex-vivo canine tissue. Focal waveforms were measured by two separate techniques using a fiber-optic hydrophone. Inertial cavitation was identified by high-speed photography in optically transparent media and an acoustic passive cavitation detector. The probability of cavitation (Pcav) for a single pulse as a function of peak negative pressure (p−) followed a sigmoid curve, with the probability approaching 1 when the pressure amplitude was sufficient. The statistical threshold (defined as Pcav = 0.5) was between p− = 26.0–30.0 MPa in all samples with a high water content, but varied between p− = 13.7 to > 36 MPa for other media. A model for radial cavitation bubble dynamics was employed to evaluate the behavior of cavitation nuclei at these pressure levels. A single bubble nucleus with an inertial cavitation threshold of p− = 28.2 MPa was estimated to have a 2.5 nm radius in distilled water. These data may be valuable for cavitation-based ultrasound therapy to predict the likelihood of cavitation at different pressure levels and dimensions of cavitation-induced lesions in tissue. PMID:23380152

  3. Impact of propagating and standing waves on cavitation appearance.

    PubMed

    Kenis, Alexander M; Grinfeld, Javier; Zadicario, Eyal; Vitek, Shuki

    2012-01-01

    Standing waves play a significant role in the appearance of cavitation phenomena. The goal of this study was to investigate the effect that the relation between standing and propagating waves in a focused field has on acoustic bubble cloud formation. Measurements of the cavitation signals were performed on five different configurations of a hemispheric phased array transducer (230 kHz) representing a wide range of relations between propagating and standing waves. The results show that configurations with a larger propagating component induce bubble clouds at lower pressures than configurations with a larger standing component.

  4. A comparison of acoustic cavitation detection thresholds measured with piezo-electric and fiber-optic hydrophone sensors.

    PubMed

    Bull, Victoria; Civale, John; Rivens, Ian; Ter Haar, Gail

    2013-12-01

    A Fabry-Perot interferometer fiber-optic hydrophone (FOH) was investigated for use as an acoustic cavitation detector and compared with a piezo-ceramic passive cavitation detector (PCD). Both detectors were used to measure negative pressure thresholds for broadband emissions in 3% agar and ex vivo bovine liver simultaneously. FOH-detected half- and fourth-harmonic emissions were also studied. Three thresholds were defined and investigated: (i) onset of cavitation; (ii) 100% probability of cavitation; and (iii) a time-integrated threshold where broadband signals integrated over a 3-s exposure duration, averaged over 5-10 repeat exposures, become statistically significantly greater than noise. The statistical sensitiviy of FOH broadband detection was low compared with that of the PCD (0.43/0.31 in agar/liver). FOH-detected fourth-harmonic data agreed best with PCD broadband (sensitivity: 0.95/0.94, specificity: 0.89/0.76 in agar/liver). The FOH has potential as a cavitation detector, particularly in applications where space is limited or during magnetic resonance-guided studies.

  5. Towards a reference ultrasonic cavitation vessel. Part 1: preliminary investigation of the acoustic field distribution in a 25 kHz cylindrical cell.

    PubMed

    Hodnett, Mark; Choi, Min Joo; Zeqiri, Bajram

    2007-01-01

    The acoustic field produced by a 25 kHz, 25 l cylindrical sonochemical processing cell has been characterised systematically using a sonar hydrophone, with the aim of establishing it as a reference test bed on which future investigations into acoustic cavitation activity may be based. Data acquired at sonication levels up to 500 W have shown that though significant cavitation activity is generated throughout the vessel, the acoustic field generated is reproducible, typically to +/- 12%. The increases in acoustic pressure are shown to be nonlinear with applied power, suggesting an intermediate optimum level for future study.

  6. The effect of static pressure on the inertial cavitation threshold.

    PubMed

    Bader, Kenneth B; Raymond, Jason L; Mobley, Joel; Church, Charles C; Felipe Gaitan, D

    2012-08-01

    The amplitude of the acoustic pressure required to nucleate a gas or vapor bubble in a fluid, and to have that bubble undergo an inertial collapse, is termed the inertial cavitation threshold. The magnitude of the inertial cavitation threshold is typically limited by mechanisms other than homogeneous nucleation such that the theoretical maximum is never achieved. However, the onset of inertial cavitation can be suppressed by increasing the static pressure of the fluid. The inertial cavitation threshold was measured in ultrapure water at static pressures up to 30 MPa (300 bars) by exciting a radially symmetric standing wave field in a spherical resonator driven at a resonant frequency of 25.5 kHz. The threshold was found to increase linearly with the static pressure; an exponentially decaying temperature dependence was also found. The nature and properties of the nucleating mechanisms were investigated by comparing the measured thresholds to an independent analysis of the particulate content and available models for nucleation.

  7. Validation of an approximate model for the thermal behavior in acoustically driven bubbles.

    PubMed

    Stricker, Laura; Prosperetti, Andrea; Lohse, Detlef

    2011-11-01

    The chemical production of radicals inside acoustically driven bubbles is determined by the local temperature inside the bubbles. Therefore, modeling of chemical reaction rates in bubbles requires an accurate evaluation of the temperature field and the heat exchange with the liquid. The aim of the present work is to compare a detailed partial differential equation model in which the temperature field is spatially resolved with an ordinary differential equation model in which the bubble contents are assumed to have a uniform average temperature and the heat exchanges are modeled by means of a boundary layer approximation. The two models show good agreement in the range of pressure amplitudes in which the bubble is spherically stable. PMID:22087996

  8. Stable tridimensional bubble clusters in multi-bubble sonoluminescence (MBSL).

    PubMed

    Rosselló, J M; Dellavale, D; Bonetto, F J

    2015-01-01

    In the present work, stable clusters made of multiple sonoluminescent bubbles are experimentally and theoretically studied. Argon bubbles were acoustically generated and trapped using bi-frequency driving within a cylindrical chamber filled with a sulfuric acid aqueous solution (SA85w/w). The intensity of the acoustic pressure field was strong enough to sustain, during several minutes, a large number of positionally and spatially fixed (without pseudo-orbits) sonoluminescent bubbles over an ellipsoidally-shaped tridimensional array. The dimensions of the ellipsoids were studied as a function of the amplitude of the applied low-frequency acoustic pressure (PAc(LF)) and the static pressure in the fluid (P0). In order to explain the size and shape of the bubble clusters, we performed a series of numerical simulations of the hydrodynamic forces acting over the bubbles. In both cases the observed experimental behavior was in excellent agreement with the numerical results. The simulations revealed that the positionally stable region, mainly determined by the null primary Bjerknes force (F→Bj), is defined as the outer perimeter of an axisymmetric ellipsoidal cluster centered in the acoustic field antinode. The role of the high-frequency component of the pressure field and the influence of the secondary Bjerknes force are discussed. We also investigate the effect of a change in the concentration of dissolved gas on the positional and spatial instabilities through the cluster dimensions. The experimental and numerical results presented in this paper are potentially useful for further understanding and modeling numerous current research topics regarding multi-bubble phenomena, e.g. forces acting on the bubbles in multi-frequency acoustic fields, transient acoustic cavitation, bubble interactions, structure formation processes, atomic and molecular emissions of equal bubbles and nonlinear or unsteady acoustic pressure fields in bubbly media. PMID:24974006

  9. Stable tridimensional bubble clusters in multi-bubble sonoluminescence (MBSL).

    PubMed

    Rosselló, J M; Dellavale, D; Bonetto, F J

    2015-01-01

    In the present work, stable clusters made of multiple sonoluminescent bubbles are experimentally and theoretically studied. Argon bubbles were acoustically generated and trapped using bi-frequency driving within a cylindrical chamber filled with a sulfuric acid aqueous solution (SA85w/w). The intensity of the acoustic pressure field was strong enough to sustain, during several minutes, a large number of positionally and spatially fixed (without pseudo-orbits) sonoluminescent bubbles over an ellipsoidally-shaped tridimensional array. The dimensions of the ellipsoids were studied as a function of the amplitude of the applied low-frequency acoustic pressure (PAc(LF)) and the static pressure in the fluid (P0). In order to explain the size and shape of the bubble clusters, we performed a series of numerical simulations of the hydrodynamic forces acting over the bubbles. In both cases the observed experimental behavior was in excellent agreement with the numerical results. The simulations revealed that the positionally stable region, mainly determined by the null primary Bjerknes force (F→Bj), is defined as the outer perimeter of an axisymmetric ellipsoidal cluster centered in the acoustic field antinode. The role of the high-frequency component of the pressure field and the influence of the secondary Bjerknes force are discussed. We also investigate the effect of a change in the concentration of dissolved gas on the positional and spatial instabilities through the cluster dimensions. The experimental and numerical results presented in this paper are potentially useful for further understanding and modeling numerous current research topics regarding multi-bubble phenomena, e.g. forces acting on the bubbles in multi-frequency acoustic fields, transient acoustic cavitation, bubble interactions, structure formation processes, atomic and molecular emissions of equal bubbles and nonlinear or unsteady acoustic pressure fields in bubbly media.

  10. Acoustic localization in weakly compressible elastic media containing random air bubbles.

    PubMed

    Liang, Bin; Cheng, Jian-chun

    2007-01-01

    We study theoretically the propagation of longitudinal wave in weakly compressible elastic media containing random air bubbles by using a self-consistent method. By inspecting the scattering cross section of an individual bubble and estimating the mean free paths of the elastic wave propagating in the bubbly weakly compressible media, the mode conversion is numerically proved negligible as the longitudinal wave is scattered by the bubbles. On the basis of the bubble dynamic equation, the wave propagation is solved rigorously with the multiple scattering effects incorporated. In a range of frequency slightly above the bubble resonance frequency, the acoustic localization in such a class of media is theoretically identified with even a very small volume fraction of bubbles. We present a method by analyzing the spatial correlation of wave field to identify the phenomenon of localization, which turns out to be effective. The sensibility of the features of localization to the structure parameters is numerically investigated. The spatial distribution of acoustic energy is also studied and the results show that the waves are trapped within a spatial domain adjacent to the source when localization occurs.

  11. Effect of hydrodynamic cavitation in the tissue erosion by pulsed high-intensity focused ultrasound (pHIFU)

    NASA Astrophysics Data System (ADS)

    Zhou, Yufeng; Gao, Xiaobin Wilson

    2016-09-01

    High-intensity focused ultrasound (HIFU) is emerging as an effective therapeutic modality in clinics. Besides the thermal ablation, tissue disintegration is also possible because of the interaction between the distorted HIFU bursts and either bubble cloud or boiling bubble. Hydrodynamic cavitation is another type of cavitation and has been employed widely in industry, but its role in mechanical erosion to tissue is not clearly known. In this study, the bubble dynamics immediately after the termination of HIFU exposure in the transparent gel phantom was captured by high-speed photography, from which the bubble displacement towards the transducer and the changes of bubble size was quantitatively determined. The characteristics of hydrodynamic cavitation due to the release of the acoustic radiation force and relaxation of compressed surrounding medium were found to associate with the number of pulses delivered and HIFU parameters (i.e. pulse duration and pulse repetition frequency). Because of the initial big bubble (~1 mm), large bubble expansion (up to 1.76 folds), and quick bubble motion (up to ~1 m s-1) hydrodynamic cavitation is significant after HIFU exposure and may lead to mechanical erosion. The shielding effect of residual tiny bubbles would reduce the acoustic energy delivered to the pre-existing bubble at the focus and, subsequently, the hydrodynamic cavitation effect. Tadpole shape of mechanical erosion in ex vivo porcine kidney samples was similar to the contour of bubble dynamics in the gel. Liquefied tissue was observed to emit towards the transducer through the punctured tissue after HIFU exposure in the sonography. In summary, the release of HIFU exposure-induced hydrodynamic cavitation produces significant bubble expansion and motion, which may be another important mechanism of tissue erosion. Understanding its mechanism and optimizing the outcome would broaden and enhance HIFU applications.

  12. Effect of hydrodynamic cavitation in the tissue erosion by pulsed high-intensity focused ultrasound (pHIFU)

    NASA Astrophysics Data System (ADS)

    Zhou, Yufeng; Gao, Xiaobin Wilson

    2016-09-01

    High-intensity focused ultrasound (HIFU) is emerging as an effective therapeutic modality in clinics. Besides the thermal ablation, tissue disintegration is also possible because of the interaction between the distorted HIFU bursts and either bubble cloud or boiling bubble. Hydrodynamic cavitation is another type of cavitation and has been employed widely in industry, but its role in mechanical erosion to tissue is not clearly known. In this study, the bubble dynamics immediately after the termination of HIFU exposure in the transparent gel phantom was captured by high-speed photography, from which the bubble displacement towards the transducer and the changes of bubble size was quantitatively determined. The characteristics of hydrodynamic cavitation due to the release of the acoustic radiation force and relaxation of compressed surrounding medium were found to associate with the number of pulses delivered and HIFU parameters (i.e. pulse duration and pulse repetition frequency). Because of the initial big bubble (~1 mm), large bubble expansion (up to 1.76 folds), and quick bubble motion (up to ~1 m s‑1) hydrodynamic cavitation is significant after HIFU exposure and may lead to mechanical erosion. The shielding effect of residual tiny bubbles would reduce the acoustic energy delivered to the pre-existing bubble at the focus and, subsequently, the hydrodynamic cavitation effect. Tadpole shape of mechanical erosion in ex vivo porcine kidney samples was similar to the contour of bubble dynamics in the gel. Liquefied tissue was observed to emit towards the transducer through the punctured tissue after HIFU exposure in the sonography. In summary, the release of HIFU exposure-induced hydrodynamic cavitation produces significant bubble expansion and motion, which may be another important mechanism of tissue erosion. Understanding its mechanism and optimizing the outcome would broaden and enhance HIFU applications.

  13. Orbital revolution of a pair of bubbles in an acoustic field

    NASA Astrophysics Data System (ADS)

    Shirota, Minori; Yamashita, Kou; Inamura, Takao

    2011-11-01

    This experimental study aims to clarify the mechanism of orbital motion of two oscillating bubbles in an acoustic field. Trajectory of the orbital motion was observed using a high-speed video camera. Because of a good repeatability in volume oscillation of bubbles, we were also able to observe the radial motion driven at 24 kHz by stroboscopic like imaging; the cyclic bubble oscillation was appeared to slow down by capturing images at the framing rate close to the forcing frequency. The orbital motions of bubbles raging from 0.13 to 0.18 mm were examined with different forcing amplitude and in different viscous oils. As a result, we found that pairs of bubbles revolve along a circular orbit around the center of mass of the orbiting two bubbles. We also found that the two bubbles perform anti-phase radial oscillation. Although this radial oscillation should result in a repulsive secondary Bjerknes force, the bubbles kept a constant separate distance of about 1 mm, which indicates the existence of centripetal primary Bjerknes force. The angular velocity of orbital revolution increases linearly with the increase in Bjerknes force.

  14. Tunneling effects in resonant acoustic scattering of an air bubble in unbounded water.

    PubMed

    Simão, André G; Guimarães, Luiz G

    2016-01-01

    The problem of acoustic scattering of a gaseous spherical bubble immersed within unbounded liquid surrounding is considered in this work. The theory of partial wave expansion related to this problem is revisited. A physical model based on the analogy between acoustic scattering and potential scattering in quantum mechanics is proposed to describe and interpret the acoustical natural oscillation modes of the bubble, namely, the resonances. In this context, a physical model is devised in order to describe the air water interface and the implications of the high density contrast on the various regimes of the scattering resonances. The main results are presented in terms of resonance lifetime periods and quality factors. The explicit numerical calculations are undertaken through an asymptotic analysis considering typical bubble dimensions and underwater sound wavelengths. It is shown that the resonance periods are scaled according to the Minnaert's period, which is the short lived resonance mode, called breathing mode of the bubble. As expected, resonances with longer lifetimes lead to impressive cavity quality Q-factor ranging from 1010 to 105. The present theoretical findings lead to a better understanding of the energy storage mechanism in a bubbly medium. PMID:27331803

  15. Air bubbles in water: a strongly multiple scattering medium for acoustic waves.

    PubMed

    Kafesaki, M; Penciu, R S; Economou, E N

    2000-06-26

    Using a newly developed multiple scattering scheme, we calculate band structure and transmission properties for acoustic waves propagating in bubbly water. We prove that the multiple scattering effects are responsible for the creation of wide gaps in the transmission even in the presence of strong positional and size disorder.

  16. Determination of the Accommodation Coefficient Using Vapor/gas Bubble Dynamics in an Acoustic Field

    NASA Technical Reports Server (NTRS)

    Gumerov, Nail A.; Hsiao, Chao-Tsung; Goumilevski, Alexei G.; Allen, Jeff (Technical Monitor)

    2001-01-01

    Nonequilibrium liquid/vapor phase transformations can occur in superheated or subcooled liquids in fast processes such as in evaporation in a vacuum. The rate at which such a phase transformation occurs depends on the "condensation" or "accommodation" coefficient, Beta, which is a property of the interface. Existing measurement techniques for Beta are complex and expensive. The development of a relatively inexpensive and reliable technique for measurement of Beta for a wide range of substances and temperatures is of great practical importance. The dynamics of a bubble in an acoustic field strongly depends on the value of Beta. It is known that near the saturation temperature, small vapor bubbles grow under the action of an acoustic field due to "rectified heat transfer." This finding can be used as the basis for an effective measurement technique of Beta. We developed a theory of vapor bubble behavior in an isotropic acoustic wave and in a plane standing acoustic wave. A numerical code was developed which enables simulation of a variety of experimental situations and accurately takes into account slowly evolving temperature. A parametric study showed that the measurement of Beta can be made over a broad range of frequencies and bubble sizes. We found several interesting regimes and conditions which can be efficiently used for measurements of Beta. Measurements of Beta can be performed in both reduced and normal gravity environments.

  17. Quantum Analogies in the Interaction between Acoustic Waves and Bubble Clouds

    NASA Astrophysics Data System (ADS)

    Parrales, Miguel A.; Rodriguez-Rodriguez, Javier

    2014-11-01

    Analogies between quantum mechanical and acoustical propagation phenomena have a great interest in academic research due to their ability to shed light on some complex quantum effects, which are impossible to visualize directly in the macroscopic world. In this talk, we describe a number of these analogies concerning the acoustic behavior of bubble clouds. Firstly, we show that the structure of the collective oscillation modes of a spherical bubble cloud resembles that of the atomic orbitals of a hydrogen atom. Secondly, we present an analogy between some perturbation methods used in quantum-electrodynamics and the computation of the acoustic response of the randomly distributed bubble cloud by considering the contribution to the total scattered pressure of the multiple scattering paths that take place inside the clouds. As an application of this analogy, we obtain the scattering cross-section of a diluted cloud, which remarkably mimics the quantum scattering of an neutron wave when passing through an atomic nucleus. Finally, we numerically reproduce the behavior of an electron in a covalent bond between two hydrogen atoms by simulating the acoustic wave propagation through two neighboring spherical bubble assemblages. Funded by the Spanish Ministry of Economy and Competitiveness through Grants DPI2011-28356-C03-01 and DPI2011-28356-C03-02.

  18. Enhanced and reduced transmission of acoustic waves with bubble meta-screens

    NASA Astrophysics Data System (ADS)

    Bretagne, Alice; Tourin, Arnaud; Leroy, Valentin

    2011-11-01

    We present a class of sonic meta-screens for manipulating air-borne acoustic waves at ultrasonic or audible frequencies. Our screens consist of periodic arrangements of air bubbles in water or possibly embedded in a soft elastic matrix. They can be used for soundproofing but also for exalting transmission at an air/water interface or even to achieve enhanced absorption.

  19. A method for estimating time-dependent acoustic cross-sections of bubbles and bubble clouds prior to the steady state

    PubMed

    Clarke; Leighton

    2000-04-01

    Models for the acoustic cross-sections of gas bubbles undergoing steady-state pulsation in liquid have existed for some time. This article presents a theoretical scheme for estimating the cross-sections of single bubbles, and bubble clouds, from the start of insonation onward. In this period the presence of transients can significantly alter the cross-section from the steady-state value. The model combines numerical solutions of the Herring-Keller model with appropriate damping values to calculate the extinction cross-section of a bubble as a function of time in response to a continuous harmonic sound field (it is also shown how the model can be adapted to estimate the time-dependent scatter cross-section). The model is then extended to determine the extinction cross-section area of multiple bubbles of varying population distributions assuming no bubble-bubble interactions. The results have shown that the time taken to reach steady state is dependent on the closeness of the bubble to resonance, and on the driving pressure amplitude. In the response of the population as a whole, the time to reach steady state tends to decrease with increasing values of the driving pressure amplitude; and with the increasing values of the ratio of the numbers of bubbles having radii much larger than resonance to the number of resonant bubbles. The implications of these findings for the use of acoustic pulses are explored.

  20. Acoustic monitoring of gas emissions from the seafloor. Part I: quantifying the volumetric flow of bubbles

    NASA Astrophysics Data System (ADS)

    Leblond, Isabelle; Scalabrin, Carla; Berger, Laurent

    2014-09-01

    Three decades of continuous ocean exploration have led us to identify subsurface fluid related processes as a key phenomenon in marine earth science research. The number of seep areas located on the seafloor has been constantly increasing with the use of multi-scale imagery techniques. Due to recent advances in transducer technology and computer processing, multibeam echosounders are now commonly used to detect submarine gas seeps escaping from the seafloor into the water column. A growing number of en- route surveys shows that sites of gas emissions escaping from the seafloor are much more numerous than previously thought. Estimating the temporal variability of the gas flow rate and volumes escaping from the seafloor has thus become a challenge of relevant interest which could be addressed by sea-floor continuous acoustic monitoring. Here, we investigate the feasibility of estimating the volumetric flow rates of gas emissions from horizontal backscattered acoustic signals. Different models based on the acoustic backscattering theory of bubbles are presented. The forward volume backscattering strength and the inversion volumetric flow rate solutions were validated with acoustic measurements from artificial gas flow rates generated in controlled sea-water tank experiments. A sensitivity analysis was carried out to investigate the behavior of the 120-kHz forward solution with respect to model input parameters (horizontal distance between transducer and bubble stream, bubble size distribution and ascent rate). The most sensitive parameter was found to be the distance of the bubble stream which can affect the volume backscattering strength by 20 dB within the horizontal range of 0-200 m. Results were used to derive the detection probability of a bubble stream for a given volume backscattering strength threshold according to different bubble flow rates and horizontal distance.

  1. EXPERIMENTS AND SIMULATIONS WITH LARGE GAS BUBBLES IN MERCURY TOWARDS ESTABLISHING A GAS LAYER TO MITIGATE CAVITATION DAMAGE

    SciTech Connect

    Wendel, Mark W; Riemer, Bernie; Felde, David K; Ruggles, Arthur; Karnowski, Thomas Paul

    2006-01-01

    One of several options that shows promise for protecting solid surfaces from cavitation damage in liquid metal spallation targets, involves introducing an interstitial gas layer between the liquid metal and the containment vessel wall. Several approaches toward establishing such a protective gas layer are being investigated at the Oak Ridge National Laboratory including large bubble injection, and methods that involve stabilization of the layer by surface modifications to enhance gas hold-up on the wall or by inserting a porous media. It has previously been reported that using a gas layer configuration in a test target showed an order-of-magnitude decrease in damage for an in-beam experiment. Video images that were taken of the successful gas/mercury flow configuration have been analyzed and correlated. The results show that the success was obtained under conditions where only 60% of the solid wall was covered with gas. Such a result implies that this mitigation scheme may have much more potential. Additional experiments with gas injection into water are underway. Multi-component flow simulations are also being used to provide direction for these new experiments. These simulations have been used to size the gas layer and position multiple inlet nozzles.

  2. Detection of cavitation in hydraulic turbines

    NASA Astrophysics Data System (ADS)

    Escaler, Xavier; Egusquiza, Eduard; Farhat, Mohamed; Avellan, François; Coussirat, Miguel

    2006-05-01

    An experimental investigation has been carried out in order to evaluate the detection of cavitation in actual hydraulic turbines. The methodology is based on the analysis of structural vibrations, acoustic emissions and hydrodynamic pressures measured in the machine. The proposed techniques have been checked in real prototypes suffering from different types of cavitation. In particular, one Kaplan, two Francis and one Pump-Turbine have been investigated in the field. Additionally, one Francis located in a laboratory has also been tested. First, a brief description of the general features of cavitation phenomenon is given as well as of the main types of cavitation occurring in hydraulic turbines. The work presented here is focused on the most important ones which are the leading edge cavitation due to its erosive power, the bubble cavitation because it affects the machine performance and the draft tube swirl that limits the operation stability. Cavitation detection is based on the previous understanding of the cavity dynamics and its location inside the machine. This knowledge has been gained from flow visualisations and measurements in laboratory devices such as a high-speed cavitation tunnel and a reduced scale turbine test rig. The main techniques are the study of the high frequency spectral content of the signals and of their amplitude demodulation for a given frequency band. Moreover, low frequency spectral content can also be used in certain cases. The results obtained for the various types of cavitation found in the selected machines are presented and discussed in detail in the paper. Conclusions are drawn about the best sensor, measuring location, signal processing and analysis for each type of cavitation, which serve to validate and to improve the detection techniques.

  3. Dynamics of soap bubble bursting and its implications to volcano acoustics

    NASA Astrophysics Data System (ADS)

    Vidal, V.; Ripepe, M.; Divoux, T.; Legrand, D.; Géminard, J.-C.; Melo, F.

    2010-04-01

    In order to assess the physical mechanisms at stake when giant gas bubbles burst at the top of a magma conduit, laboratory experiments have been performed. An overpressurized gas cavity is initially closed by a thin liquid film, which suddenly bursts. The acoustic signal produced by the bursting is investigated. The key result is that the amplitude and energy of the acoustic signal strongly depend on the film rupture time. As the rupture time is uncontrolled in the experiments and in the field, the measurement of the acoustic excess pressure in the atmosphere, alone, cannot provide any information on the overpressure inside the bubble before explosion. This could explain the low energy partitioning between infrasound, seismic and explosive dynamics often observed on volcanoes.

  4. Microbubble Cavitation Imaging

    PubMed Central

    Vignon, Francois; Shi, William T.; Powers, Jeffry E.; Everbach, E. Carr; Liu, Jinjin; Gao, Shunji; Xie, Feng; Porter, Thomas R.

    2014-01-01

    Ultrasound cavitation of microbubble contrast agents has a potential for therapeutic applications such as sonothrombolysis (STL) in acute ischemic stroke. For safety, efficacy, and reproducibility of treatment, it is critical to evaluate the cavitation state (moderate oscillations, stable cavitation, and inertial cavitation) and activity level in and around a treatment area. Acoustic passive cavitation detectors (PCDs) have been used to this end but do not provide spatial information. This paper presents a prototype of a 2-D cavitation imager capable of producing images of the dominant cavitation state and activity level in a region of interest. Similar to PCDs, the cavitation imaging described here is based on the spectral analysis of the acoustic signal radiated by the cavitating microbubbles: ultraharmonics of the excitation frequency indicate stable cavitation, whereas elevated noise bands indicate inertial cavitation; the absence of both indicates moderate oscillations. The prototype system is a modified commercially available ultrasound scanner with a sector imaging probe. The lateral resolution of the system is 1.5 mm at a focal depth of 3 cm, and the axial resolution is 3 cm for a therapy pulse length of 20 µs. The maximum frame rate of the prototype is 2 Hz. The system has been used for assessing and mapping the relative importance of the different cavitation states of a microbubble contrast agent. In vitro (tissue-mimicking flow phantom) and in vivo (heart, liver, and brain of two swine) results for cavitation states and their changes as a function of acoustic amplitude are presented. PMID:23549527

  5. Sensitivity of free radicals production in acoustically driven bubble to the ultrasonic frequency and nature of dissolved gases.

    PubMed

    Merouani, Slimane; Hamdaoui, Oualid; Rezgui, Yacine; Guemini, Miloud

    2015-01-01

    Central events of ultrasonic action are the bubbles of cavitation that can be considered as powered microreactors within which high-energy chemistry occurs. This work presents the results of a comprehensive numerical assessment of frequency and saturating gases effects on single bubble sonochemistry. Computer simulations of chemical reactions occurring inside a bubble oscillating in liquid water irradiated by an ultrasonic wave have been performed for a wide range of ultrasonic frequencies (213-1100kHz) under different saturating gases (O2, air, N2 and H2). For O2 and H2 bubbles, reactions mechanism consisting in 25 reversible chemical reactions were proposed for studying the internal bubble-chemistry whereas 73 reversible reactions were taken into account for air and N2 bubbles. The numerical simulations have indicated that radicals such as OH, H, HO2 and O are created in the bubble during the strong collapse. In all cases, hydroxyl radical (OH) is the main oxidant created in the bubble. The production rate of the oxidants decreases as the driving ultrasonic frequency increases. The production rate of OH radical followed the order O2>air>N2>H2 and the order becomes more remarkable at higher ultrasonic frequencies. The effect of ultrasonic frequency on single bubble sonochemistry was attributed to its significant impact on the cavitation process whereas the effects of gases were attributed to the nature of the chemistry produced in the bubble at the strong collapse. It was concluded that, in addition to the gas solubility, the nature of the internal bubble chemistry is another parameter of a paramount importance that controls the overall sonochemical activity in aqueous solutions. PMID:25112684

  6. FOREWORD: International Symposium of Cavitation and Multiphase Flow (ISCM 2014)

    NASA Astrophysics Data System (ADS)

    Wu, Yulin

    2015-01-01

    multiphase flow detection Fluid-structure interaction induced by cavitation and multiphase flow Multi-scale modelling of cavitating flows and Multiphase Flow Cavitation nuclei: theory and experiments Supercavitation and its applications Synergetic effects of cavitation and silt-laden erosion Shock waves and microjets generated by cavitation Nonlinear oscillations of gas and vapour bubbles Fundamentals of physics of acoustic cavitation Sonochemistry and sonoluminescence Biomedical applications of cavitation effects Ultrasonic cavitation for molten metal treatment Cavitation for enhanced heat transfer The ISCM 2014 brought together 95 scientists, researchers and graduate students from 11 countries, affiliated with universities, technology centers and industrial firms to debate topics related to advanced technologies for cavitation and Multiphase Flow, which would enhance the sustainable development of cavitation and Multiphase Flow in interdisciplinary sciences and technology. The technical committee selected 54 technical papers on the following topics: (i) Hydrodynamic Cavitation, (ii) Super Cavitation, (iii) Pump Cavitation, (iv) Acoustic Cavitation, (v) Interdisciplinary Research of Cavitation and Multi-Phase Flows, and 13 invited plenary and invited forum lectures, which were presented at the symposium, to be included in the proceedings. All the papers of ISCM 2014, which are published in this Volume of IOP Conference Series: Materials Science and Engineering, had been peer reviewed through processes administered by the editors of the ISCM 2014, those are Yulin WU, Shouqi YUAN, Zhengwei WANG, Shuhong LIU, Xingqi LUO, Fujun WANG and Guoyu WANG. The papers published in this Volume include 54 technical papers and 3 full length texts of the invited lectures. We sincerely hope that the International Symposium on Cavitation and Multiphase Flow is a significant step forward in the world wide efforts to address the present challenges in the modern science and technology. Professor

  7. A method to account for acoustic microstreaming when predicting bubble growth rates produced by rectified diffusion.

    PubMed

    Church, C C

    1988-11-01

    A reinterpretation of existing theory for rectified diffusion, the process by which bubbles in a sound field may grow in radius, is presented in order to quantitate the effect of acoustic microstreaming on bubble growth rates. The 1/t term in the growth rate equation is defined as the "decay term" and t as the "decay time," the time required for the gas concentration in the liquid contacting the bubble to rise (or fall) from its initial to its final value. In the absence of microstreaming, t is the duration of sonification. In the presence of microstreaming, t may be calculated from the streaming velocity and the bubble radius. A comparison between theory and the experimental results of Eller [A. Eller, J. Acoust. Soc. Am. 46, 1246-1250 (1969)] and of Gould [R.K. Gould, J. Acoust. Soc. Am. 56, 1740-1746 (1974)] shows reasonable agreement in the low kHz range. Theoretical results in the frequency range of 1-10 MHz at 1 and 4 bar are also presented.

  8. A detector for monitoring the onset of cavitation during therapy-level measurements of ultrasonic power

    NASA Astrophysics Data System (ADS)

    Hodnett, M.; Zeqiri, B.

    2004-01-01

    Acoustic cavitation occurring in the water path between a transducer and the target of a radiation force balance can provide a significant source of error during measurements of ultrasonic power. These problems can be particularly acute at physiotherapy levels (>1 W), and low frequencies (leq 1 MHz). The cavitating bubbles can absorb and scatter incident ultrasound, leading to an underestimate in the measured power. For these reasons, International Specification standards demand the use of degassed water. This imposes requirements that may actually be difficult to meet, for example, in the case of hospitals. Also, initially degassed water will rapidly re-gas, increasing the likelihood of cavitation occurring. For these reasons, NPL has developed a device that monitors acoustic emissions generated by bubble activity, for detecting the onset of cavitation during power measurements. A commercially available needle hydrophone is used to detect these emissions. The acoustic signals are then monitored using a Cavitation Detector (CD) unit, comprising an analogue electrical filter that may be tuned to detect frequency components generated by cavitating bubbles, and which provides an indication of when the measured level exceeds a pre-defined threshold. This paper describes studies to establish a suitable detection scheme, the principles of operation of the CD unit, and the performance tests carried out with a range of propagation media.

  9. The cavitation induced Becquerel effect and the hot spot theory of sonoluminescence.

    PubMed

    Prevenslik, T V

    2003-06-01

    Over 150 years ago, Becquerel discovered the ultraviolet illumination of one of a pair of identical electrodes in liquid water produced an electric current, the phenomenon called the Becquerel effect. Recently, a similar effect was observed if the water surrounding one electrode is made to cavitate by focused acoustic radiation, which by similarity is referred to as the cavitation induced Becquerel effect. The current in the cavitation induced Becquerel effect was found to be semi-logarithmic with the standard electrode potential that is consistent with the oxidation of the electrode surface by the photo-decomposition theory of photoelectrochemistry. But oxidation of the electrode surface usually requires high temperatures, say as in cavitation. Absent high bubble temperatures, cavitation may produce vacuum ultraviolet (VUV) light that excites water molecules in the electrode film to higher H(2)O(*) energy states, the excited states oxidizing the electrode surface by chemical reaction. Solutions of the Rayleigh-Plesset equation during bubble collapse that include the condensation of water vapor show any increase in temperature or pressure of the water vapor by compression heating is compensated by the condensation of vapor to the bubble wall, the bubbles collapsing almost isothermally. Hence, the cavitation induced Becquerel effect is likely caused by cavitation induced VUV light at ambient temperature. PMID:12782265

  10. Nonequilibrium bubbles in a flowing langmuir monolayer.

    PubMed

    Muruganathan, Rm; Khattari, Z; Fischer, Th M

    2005-11-24

    We investigate the nonequilibrium behavior of two-dimensional gas bubbles in Langmuir monolayers. A cavitation bubble is induced in liquid expanded phase by locally heating a Langmuir monolayer with an IR-laser. At low IR-laser power the cavitation bubble is immersed in quiescent liquid expanded monolayer. At higher IR-laser power thermo capillary flow around the laser-induced cavitation bubble sets in. The thermo capillary flow is caused by a temperature dependence of the gas/liquid line tension. The slope of the line tension with temperature is determined by measuring the thermo capillary flow velocity. Thermodynamically stable satellite bubbles are generated by increasing the surface area of the monolayer. Those satellite bubbles collide with the cavitation bubble. Upon collision the satellite bubbles either coalesce with the cavitation bubble or slide past the cavitation bubble. Moreover we show that the satellite bubbles can also be produced by the emission from the laser-induced cavitation bubbles.

  11. Nonlinear ultrasonic waves in bubbly liquids with nonhomogeneous bubble distribution: Numerical experiments.

    PubMed

    Vanhille, Christian; Campos-Pozuelo, Cleofé

    2009-06-01

    This paper deals with the nonlinear propagation of ultrasonic waves in mixtures of air bubbles in water, but for which the bubble distribution is nonhomogeneous. The problem is modelled by means of a set of differential equations which describes the coupling of the acoustic field and bubbles vibration, and solved in the time domain via the use and adaptation of the SNOW-BL code. The attenuation and nonlinear effects are assumed to be due to the bubbles exclusively. The nonhomogeneity of the bubble distribution is introduced by the presence of bubble layers (or clouds) which can act as acoustic screens, and alters the behaviour of the ultrasonic waves. The effect of the spatial distribution of bubbles on the nonlinearity of the acoustic field is analyzed. Depending on the bubble density, dimension, shape, and position of the layers, its effects on the acoustic field change. Effects such as shielding and resonance of the bubbly layers are especially studied. The numerical experiments are carried out in two configurations: linear and nonlinear, i.e. for low and high excitation pressure amplitude, respectively, and the features of the phenomenon are compared. The parameters of the medium are chosen such as to reproduce air bubbly water involved in the stable cavitation process.

  12. Equations of spatial hydrodynamic interaction of weakly nonspherical gas bubbles in liquid in an acoustic field

    NASA Astrophysics Data System (ADS)

    Davletshin, A. I.; Khalitova, T. F.

    2016-01-01

    A mathematical model of spatial hydrodynamic interaction of gas bubbles in liquid in an acoustic field taking into account small deformations of their surfaces is proposed. It is a system of ordinary differential equations of the second order in radii of the bubbles, the position vectors of their centers and the amplitudes of deviation of their shape from the spherical one in the form of spherical harmonics. The equations derived are of the first order of accuracy in A / R and of the fourth order in R / D, where R is the characteristic radius of the bubbles, A is the amplitude of characteristic deviation of their surface from the spherical one in the form of spherical harmonics, D is the characteristic distance between bubbles. The derivation of the equations is carried out by the method of spherical functions with the use of the Bernoulli integral, the kinematic and dynamic boundary conditions on the surface of the bubbles. The effects of viscosity and compressibility of the liquid are considered approximately, the gas in the bubbles is assumed homobaric.

  13. Exploring bubble oscillation and mass transfer enhancement in acoustic-assisted liquid-liquid extraction with a microfluidic device

    PubMed Central

    Xie, Yuliang; Chindam, Chandraprakash; Nama, Nitesh; Yang, Shikuan; Lu, Mengqian; Zhao, Yanhui; Mai, John D.; Costanzo, Francesco; Huang, Tony Jun

    2015-01-01

    We investigated bubble oscillation and its induced enhancement of mass transfer in a liquid-liquid extraction process with an acoustically-driven, bubble-based microfluidic device. The oscillation of individually trapped bubbles, of known sizes, in microchannels was studied at both a fixed frequency, and over a range of frequencies. Resonant frequencies were analytically identified and were found to be in agreement with the experimental observations. The acoustic streaming induced by the bubble oscillation was identified as the cause of this enhanced extraction. Experiments extracting Rhodanmine B from an aqueous phase (DI water) to an organic phase (1-octanol) were performed to determine the relationship between extraction efficiency and applied acoustic power. The enhanced efficiency in mass transport via these acoustic-energy-assisted processes was confirmed by comparisons against a pure diffusion-based process. PMID:26223474

  14. Removal of Residual Cavitation Nuclei to Enhance Histotripsy Erosion of Model Urinary Stones

    PubMed Central

    Duryea, Alexander P.; Roberts, William W.; Cain, Charles A.; Hall, Timothy L.

    2015-01-01

    Histotripsy has been shown to be an effective treatment for model kidney stones, eroding their surface to tiny particulate debris via a cavitational bubble cloud. However, similar to shock wave lithotripsy, histotripsy stone treatments display a rate-dependent efficacy with pulses applied at low rate generating more efficient stone erosion in comparison to those applied at high rate. This is hypothesized to be the result of residual cavitation bubble nuclei generated by bubble cloud collapse. While the histotripsy bubble cloud only lasts on the order of 100 µs, these microscopic remnant bubbles can persist on the order of 1 second—inducing direct attenuation of subsequent histotripsy pulses and influencing bubble cloud dynamics. In an effort to mitigate these effects, we have developed a novel strategy to actively remove residual cavitation nuclei from the field using low-amplitude ultrasound pulses. Previous work has demonstrated that with selection of the appropriate acoustic parameters these bubble removal pulses can stimulate the aggregation and subsequent coalescence of microscopic bubble nuclei—effectively deleting them from the target volume. Here, we incorporate bubble removal pulses in histotripsy treatment of model kidney stones. It was found that when histotripsy is applied at low rate (1 Hz), bubble removal does not produce a statistically significant change in erosion. At higher pulse rates of 10, 100, and 500 Hz, incorporating bubble removal results in 3.7-, 7.5-, and 2.7-fold increases in stone erosion, respectively. High speed imaging indicates that the introduction of bubble removal pulses allows bubble cloud dynamics resulting from high pulse rates to more closely approximate those generated at the low rate of 1 Hz. These results corroborate previous work in the field of shock wave lithotripsy regarding the ill-effects of residual bubble nuclei, and suggest that high treatment efficiency can be recovered at high pulse rates through

  15. CO2 bubbling-based 'Nanobomb' System for Targetedly Suppressing Panc-1 Pancreatic Tumor via Low Intensity Ultrasound-activated Inertial Cavitation.

    PubMed

    Zhang, Kun; Xu, Huixiong; Chen, Hangrong; Jia, Xiaoqing; Zheng, Shuguang; Cai, Xiaojun; Wang, Ronghui; Mou, Juan; Zheng, Yuanyi; Shi, Jianlin

    2015-01-01

    Noninvasive and targeted physical treatment is still desirable especially for those cancerous patients. Herein, we develop a new physical treatment protocol by employing CO2 bubbling-based 'nanobomb' system consisting of low-intensity ultrasound (1.0 W/cm(2)) and a well-constructed pH/temperature dual-responsive CO2 release system. Depending on the temperature elevation caused by exogenous low-intensity therapeutic ultrasound irradiation and the low pH caused by the endogenous acidic-environment around/within tumor, dual-responsive CO2 release system can quickly release CO2 bubbles, and afterwards, the generated CO2 bubbles waves will timely explode before dissolution due to triggering by therapeutic ultrasound waves. Related bio-effects (e.g., cavitation, mechanical, shock waves, etc) caused by CO2 bubbles' explosion effectively induce instant necrosis of panc-1 cells and blood vessel destruction within panc-1 tumor, and consequently inhibit the growth of panc-1 solid tumor, simultaneously minimizing the side effects to normal organs. This new physiotherapy employing CO2 bubbling-based 'nanobomb' system promises significant potentials in targetedly suppressing tumors, especially for those highly deadly cancers.

  16. CO2 bubbling-based 'Nanobomb' System for Targetedly Suppressing Panc-1 Pancreatic Tumor via Low Intensity Ultrasound-activated Inertial Cavitation

    PubMed Central

    Zhang, Kun; Xu, Huixiong; Chen, Hangrong; Jia, Xiaoqing; Zheng, Shuguang; Cai, Xiaojun; Wang, Ronghui; Mou, Juan; Zheng, Yuanyi; Shi, Jianlin

    2015-01-01

    Noninvasive and targeted physical treatment is still desirable especially for those cancerous patients. Herein, we develop a new physical treatment protocol by employing CO2 bubbling-based 'nanobomb' system consisting of low-intensity ultrasound (1.0 W/cm2) and a well-constructed pH/temperature dual-responsive CO2 release system. Depending on the temperature elevation caused by exogenous low-intensity therapeutic ultrasound irradiation and the low pH caused by the endogenous acidic-environment around/within tumor, dual-responsive CO2 release system can quickly release CO2 bubbles, and afterwards, the generated CO2 bubbles waves will timely explode before dissolution due to triggering by therapeutic ultrasound waves. Related bio-effects (e.g., cavitation, mechanical, shock waves, etc) caused by CO2 bubbles' explosion effectively induce instant necrosis of panc-1 cells and blood vessel destruction within panc-1 tumor, and consequently inhibit the growth of panc-1 solid tumor, simultaneously minimizing the side effects to normal organs. This new physiotherapy employing CO2 bubbling-based 'nanobomb' system promises significant potentials in targetedly suppressing tumors, especially for those highly deadly cancers. PMID:26379793

  17. Passive acoustic derived bubble flux and applications to natural gas seepage in the Mackenzie Delta, NWT, Canada and Coal Oil Point, CA

    NASA Astrophysics Data System (ADS)

    Culling, D.; Leifer, I.; Dallimore, S.; Alcala, K.

    2012-12-01

    Methane is a prominent greenhouse gas that escapes naturally from thermogenic reservoirs as seepage from marine and lacustrine biogenic sources as bubble ebullition. Geologic methane emissions are critically important contributors to the global methane budget however, few quantitative flux measurements are available for shallow waters. This gap in knowledge is critical as in these settings gas can easily transit as bubbles through the water column and directly influence global atmospheric budgets. Video and active acoustic (sonar) measurements of bubble flux have spatial limitations requiring predictable bubble emission location. Passive acoustics are less affected by these limitations, in addition, they can provide data in water too shallow for effective sonar bubble observations. Lab tests were undertaken to quantify the acoustic signature of bubbles formed in non-cohesive sediments. specifically focusing on mechanisms that complicate interpretation of acoustic data. Lab tests then were compared to field data to provide measurement calibration/validation. The principles behind the acoustic analysis method are based on the Minnaert equation, which relates a bubble radius and acoustic frequency. Bubble size and the resultant acoustic frequency from known flows and capillary tube diameters are well documented; however changing sediment pathways adds to the complexity of bubble formation and the resultant bubble acoustic signal. These complex signals were investigated in a lab tank with a thick, cohesive fine-grained sediment bed, through which bubbles produced by a syringe pump migrated to the sediment-water interface. Then, the resultant bubbles were diverted into clear water and measured from high speed, high definition video, while the acoustic signature of bubble formation was recorded concurrently by a hydrophone. Bubble formation is influenced by currents, which shifts the acoustical signal towards a higher frequency with a more complex pattern than the

  18. Acoustic waves of different geometry in polydisperse bubble liquids: Theory and experiment

    NASA Astrophysics Data System (ADS)

    Nigmatulin, R. I.; Gubaidullin, D. A.; Fedorov, Yu. V.

    2013-06-01

    A mathematical model that determines the propagation of acoustic waves of different geometry in two-fraction mixtures of liquids with polydispersed gas bubbles of various compositions is presented. A unique dispersion relationship, which takes into account the propagation of the plane, spherical, and cylindrical perturbations in these mixtures, is derived. It is shown that the theoretical curves of the phase velocity and the damping factor agree well with the experimental data involving the resonant frequency range.

  19. An experimental study on resonance of oscillating air/vapor bubbles in water using a two-frequency acoustic apparatus

    NASA Astrophysics Data System (ADS)

    Ohsaka, K.

    2003-05-01

    A two-frequency acoustic apparatus is employed to study the growth behavior of vapor-saturated bubbles driven in a volumetric mode. A unique feature of the apparatus is its capability of trapping a bubble by an ultrasonic standing wave while independently driving it into oscillations by a second lower-frequency acoustic wave. It is observed that the growing vapor bubbles exhibit a periodic shape transition between the volumetric and shape modes due to resonant coupling. In order to explain this observation, we performed an experimental investigation on resonant coupling of air bubbles and obtained the following results: First, the induced shape oscillations are actually a mixed mode that contains the volume component, thus, vapor bubbles can grow while they exhibit shape oscillations. Second, the acoustically levitated bubbles are deformed and therefore, degeneracy in resonant frequency is partially removed. As a result, the vapor bubbles exhibit the shape oscillations in both the axisymmetric mode and asymmetric (three-dimensional) modes. Nonlinear effects in addition to the frequency shift and split due to deformation creates overlapping of the coupling ranges for different modes, which leads to the continuous shape oscillations above a certain bubble radius as the bubble grows.

  20. A method for predicting the number of active bubbles in sonochemical reactors.

    PubMed

    Merouani, Slimane; Ferkous, Hamza; Hamdaoui, Oualid; Rezgui, Yacine; Guemini, Miloud

    2015-01-01

    Knowledge of the number of active bubbles in acoustic cavitation field is very important for the prediction of the performance of ultrasonic reactors toward most chemical processes induced by ultrasound. The literature in this field is scarce, probably due to the complicated nature of the phenomena. We introduce here a relatively simple semi-empirical method for predicting the number of active bubbles in an acoustic cavitation field. By coupling the bubble dynamics in an acoustical field with chemical kinetics occurring in the bubble during oscillation, the amount of the radical species OH and HO2 and molecular H2O2 released by a single bubble was estimated. Knowing that the H2O2 measured experimentally during sonication of water comes from the recombination of hydroxyl (OH) and perhydroxyl (HO2) radicals in the liquid phase and assuming that in sonochemistry applications, the cavitation is transient and the bubble fragments at the first collapse, the number of bubbles formed per unit time per unit volume is then easily determined using material balances for H2O2, OH and HO2 in the liquid phase. The effect of ultrasonic frequency on the number of active bubbles was examined. It was shown that increasing ultrasonic frequency leads to a substantial increase in the number of bubbles formed in the reactor. PMID:25127247

  1. A method for predicting the number of active bubbles in sonochemical reactors.

    PubMed

    Merouani, Slimane; Ferkous, Hamza; Hamdaoui, Oualid; Rezgui, Yacine; Guemini, Miloud

    2015-01-01

    Knowledge of the number of active bubbles in acoustic cavitation field is very important for the prediction of the performance of ultrasonic reactors toward most chemical processes induced by ultrasound. The literature in this field is scarce, probably due to the complicated nature of the phenomena. We introduce here a relatively simple semi-empirical method for predicting the number of active bubbles in an acoustic cavitation field. By coupling the bubble dynamics in an acoustical field with chemical kinetics occurring in the bubble during oscillation, the amount of the radical species OH and HO2 and molecular H2O2 released by a single bubble was estimated. Knowing that the H2O2 measured experimentally during sonication of water comes from the recombination of hydroxyl (OH) and perhydroxyl (HO2) radicals in the liquid phase and assuming that in sonochemistry applications, the cavitation is transient and the bubble fragments at the first collapse, the number of bubbles formed per unit time per unit volume is then easily determined using material balances for H2O2, OH and HO2 in the liquid phase. The effect of ultrasonic frequency on the number of active bubbles was examined. It was shown that increasing ultrasonic frequency leads to a substantial increase in the number of bubbles formed in the reactor.

  2. Complete Inhibition Of Ultrasound Induced Cytolysis In The Presence Of Inertial Cavitation

    NASA Astrophysics Data System (ADS)

    Sostaric, Joe Z.; Miyoshi, Norio; Riesz, Peter; De Graff, William G.; Mitchell, James B.

    2006-05-01

    The investigation of ultrasound for biotechnological applications including non-invasive surgery (HIFU), drug/gene delivery to cells (sonoporation) or through the skin (sonophoresis) and ultrasound assisted bioreactors has focused mainly on the physical effects of ultrasound. The beneficial effects of ultrasound rely on a number of application-dependent mechanisms, and may include tissue heating, acoustic streaming or cavitation. Although acoustic cavitation is necessary in some systems, cavitation bubbles simultaneously result in uncontrollable cell damage and cytolysis. Thus, the development of a number of biotechnological uses of ultrasound has been hampered by the necessity to constrain exposure parameters in order to prevent the occurrence of acoustic cavitation or to at least limit the detrimental effects of cavitation. The current study shows that non-toxic concentrations of specific n-alkyl solutes completely inhibit ultrasound induced cytolysis of in vitro suspensions of human leukemia cells (HL-60). Protection of the whole cell population from cytolysis is achieved even under extreme ultrasound exposure conditions that result in cytolysis of 100 % of the cell population in the absence of the n-alkyl solutes. Furthermore, the n-alkyl solutes did not hinder the process of inertial cavitation. This method may allow utilization of beneficial effects of ultrasound and cavitation while protecting cells from cavitation induced cytolysis and thereby presents new possibilities for ultrasound in medicine and biology.

  3. The Dynamics of Bubbles and Bubble Clouds.

    NASA Astrophysics Data System (ADS)

    Smereka, Peter Stenberg

    In an effort to understand acoustic cavitation noise the dynamics of periodically driven single bubbles and bubble clouds are examined. The single bubble equations are written as a perturbation of a Hamiltonian system and the conditions for resonances to occur are found, these can interact with the nonresonant orbit to produce jump and period-doubling bifurcations. To study the chaotic behavior a map which approximates the Poincare map in the resonant band is derived. The Poincare map is computed numerically which shows the formation of strange attractors which suddenly disappear leaving behind Smale horseshoe maps. The bubble cloud is studied using an averaged two-fluid model for bubbly flow with periodic driving at the boundary. The equations are examined both analytically and numerically. Local and global existence of solutions is proved and the existence of an absorbing set is established. An analysis of the linearized equations combined with estimates on the nonlinearity is used to prove the existence of nonlinear periodic orbit. This periodic orbit is a fixed point of the Poincare map and its stability is determined by finding the spectrum of the linearized Poincare map. This calculation combined with the absorbing set proves that the long term dynamics of the bubble cloud is finite dimensional. Numerical computations show the important attractors are a periodic -two orbit and a quasi-periodic orbit.

  4. Aspherical bubble dynamics and oscillation times

    SciTech Connect

    Godwin, R.P.; Chapyak, E.J.; Noack, J.; Vogel, A.

    1999-03-01

    The cavitation bubbles common in laser medicine are rarely perfectly spherical and are often located near tissue boundaries, in vessels, etc., which introduce aspherical dynamics. Here, novel features of aspherical bubble dynamics are explored. Time-resolved experimental photographs and simulations of large aspect ratio (length:diameter {approximately}20) cylindrical bubble dynamics are presented. The experiments and calculations exhibit similar dynamics. A small high-pressure cylindrical bubble initially expands radially with hardly any axial motion. Then, after reaching its maximum volume, a cylindrical bubble collapses along its long axis with relatively little radial motion. The growth-collapse period of these very aspherical bubbles differs only sightly from twice the Rayleigh collapse time for a spherical bubble with an equivalent maximum volume. This fact justifies using the temporal interval between the acoustic signals emitted upon bubble creation and collapse to estimate the maximum bubble volume. As a result, hydrophone measurements can provide an estimate of the bubble energy even for aspherical bubbles. The prolongation of the oscillation period of bubbles near solid boundaries relative to that of isolated spherical bubbles is also discussed.

  5. Comparison of electrohydraulic lithotripters with rigid and pressure-release ellipsoidal reflectors. II. Cavitation fields.

    PubMed

    Bailey, M R; Blackstock, D T; Cleveland, R O; Crum, L A

    1999-08-01

    Dramatically different cavitation was produced by two separate acoustic pulses that had different shapes but similar duration, frequency content, and peak positive and negative pressure. Both pulses were produced by a Dornier HM-3 style lithotripter: one pulse when the ellipsoidal reflector was rigid, the other when the reflector was pressure release. The cavitation, or bubble action, generated by the conventional rigid-reflector pulse was nearly 50 times longer lived and 3-13 times stronger than that produced by the pressure-release-reflector pulse. Cavitation durations measured by passive acoustic detection and high-speed video agreed with calculations based on the Gilmore equation. Cavitation intensity, or destructive potential, was judged (1) experimentally by the size of pits in aluminum foil detectors and (2) numerically by the calculated amplitude of the shock wave emitted by a collapsing bubble. The results indicate that the trailing positive spike in the pressure-release-reflector waveform stifles bubble growth and mitigates the collapse, whereas the trough after the positive spike in the rigid-reflector waveform triggers inertially driven growth and collapse. The two reflectors therefore provide a tool to compare effects in weakly and strongly cavitating fields and thereby help assess cavitation's role in lithotripsy.

  6. Molecular emission from single-bubble sonoluminescence.

    PubMed

    Didenko, Y T; McNamara, W B; Suslick, K S

    2000-10-19

    Ultrasound can drive a single gas bubble in water into violent oscillation; as the bubble is compressed periodically, extremely short flashes of light (about 100 ps) are generated with clock-like regularity. This process, known as single-bubble sonoluminescence, gives rise to featureless continuum emission in water (from 200 to 800 nm, with increasing intensity into the ultraviolet). In contrast, the emission of light from clouds of cavitating bubbles at higher acoustic pressures (multi-bubble sonoluminescence) is dominated by atomic and molecular excited-state emission at much lower temperatures. These observations have spurred intense effort to uncover the origin of sonoluminescence and to generalize the conditions necessary for its creation. Here we report a series of polar aprotic liquids that generate very strong single-bubble sonoluminescence, during which emission from molecular excited states is observed. Previously, single-bubble sonoluminescence from liquids other than water has proved extremely elusive. Our results give direct proof of the existence of chemical reactions and the formation of molecular excited states during single-bubble cavitation, and provide a spectroscopic link between single- and multi-bubble sonoluminescence.

  7. Reply to "Comment on `Acoustical observation of bubble oscillations induced by bubble popping' "

    NASA Astrophysics Data System (ADS)

    Ding, Junqi

    2015-03-01

    We reported on the sound pressure generated by aqueous foam bursts in our paper [Ding et al., Phys. Rev. E 75, 041601 (2007), 10.1103/PhysRevE.75.041601]. Blanc et al., [Phys. Rev. E 91, 036401 (2015), 10.1103/PhysRevE.91.036401] found that sound from one of three mechanisms of bubble burst (the prepopping) actually results from an acausal artifact of the signal processing performed by their acquisition system which lies outside of its prescribed working frequency range. We examined the same hardware used in our paper and found that the frequency range is not the cause of the artifact. The prepopping sound was a result from a built-in finite impulse response filter of analog-to-digital converters in the Brüel & Kjær data acquisition system.

  8. Experimenting cavitation measuring instruments

    NASA Astrophysics Data System (ADS)

    Toulouse, G.

    1988-09-01

    A calibrating method for measuring the volume of cavitation bubbles is presented and the results of open air experiments are given. The bubbles appearing on the surface of a marine rotating propeller are measured using CCD cameras and optical procedures. Square bubble section first approximations is used. The performance of cameras equipped with light amplifiers is studied in order to use them for real bubble cross section measurements.

  9. The role of heating, cavitation and acoustic streaming in mediating ultrasound-induced changes of TGF-beta gene expression in bone cells

    NASA Astrophysics Data System (ADS)

    Harle, J.; Mayia, F.

    2004-01-01

    This paper relates ultrasound-induced changes in bone cell function to quantitative data assessing the level of several interaction mechanisms within the exposure environment. Characterisation of ultrasound fields in terms of resultant levels of heating, cavitation and acoustic streaming may provide a novel means of accurately assessing the likelihood of biological effects in vitro.

  10. Bubbles

    NASA Astrophysics Data System (ADS)

    Prosperetti, Andrea

    2004-06-01

    Vanitas vanitatum et omnia vanitas: bubbles are emptiness, non-liquid, a tiny cloud shielding a mathematical singularity. Born from chance, a violent and brief life ending in the union with the (nearly) infinite. But a wealth of phenomena spring forth from this nothingness: underwater noise, sonoluminescence, boiling, and many others. Some recent results on a "blinking bubble" micropump and vapor bubbles in sound fields are outlined. The last section describes Leonardo da Vinci's observation of the non-rectlinear ascent of buoyant bubbles and justifies the name Leonardo's paradox recently attributed to this phenomenon.

  11. Nonlinear acoustic propagation in bubbly liquids: Multiple scattering, softening and hardening phenomena.

    PubMed

    Doc, Jean-Baptiste; Conoir, Jean-Marc; Marchiano, Régis; Fuster, Daniel

    2016-04-01

    The weakly nonlinear propagation of acoustic waves in monodisperse bubbly liquids is investigated numerically. A hydrodynamic model based on the averaged two-phase fluid equations is coupled with the Rayleigh-Plesset equation to model the dynamics of bubbles at the local scale. The present model is validated in the linear regime by comparing with the Foldy approximation. The analysis of the pressure signals in the linear regime highlights two resonance frequencies: the Minnaert frequency and a multiple scattering resonance that strongly depends on the bubble concentration. For weakly nonlinear regimes, the generation of higher harmonics is observed only for the Minnaert frequency. Linear combinations between the Minnaert harmonics and the multiple scattering resonance are also observed. However, the most significant effect observed is the appearance of softening-hardening effects that share some similarities with those observed for sandstones or cracked materials. These effects are related to the multiple scattering resonance. Downward or upward resonance frequency shifts can be observed depending on the characteristic of the incident wave when increasing the excitation amplitude. It is shown that the frequency shift can be explained assuming that the acoustic wave velocity depends on a law different from those usually encountered for sandstones or cracked materials.

  12. Nonlinear acoustic propagation in bubbly liquids: Multiple scattering, softening and hardening phenomena.

    PubMed

    Doc, Jean-Baptiste; Conoir, Jean-Marc; Marchiano, Régis; Fuster, Daniel

    2016-04-01

    The weakly nonlinear propagation of acoustic waves in monodisperse bubbly liquids is investigated numerically. A hydrodynamic model based on the averaged two-phase fluid equations is coupled with the Rayleigh-Plesset equation to model the dynamics of bubbles at the local scale. The present model is validated in the linear regime by comparing with the Foldy approximation. The analysis of the pressure signals in the linear regime highlights two resonance frequencies: the Minnaert frequency and a multiple scattering resonance that strongly depends on the bubble concentration. For weakly nonlinear regimes, the generation of higher harmonics is observed only for the Minnaert frequency. Linear combinations between the Minnaert harmonics and the multiple scattering resonance are also observed. However, the most significant effect observed is the appearance of softening-hardening effects that share some similarities with those observed for sandstones or cracked materials. These effects are related to the multiple scattering resonance. Downward or upward resonance frequency shifts can be observed depending on the characteristic of the incident wave when increasing the excitation amplitude. It is shown that the frequency shift can be explained assuming that the acoustic wave velocity depends on a law different from those usually encountered for sandstones or cracked materials. PMID:27106317

  13. Acoustic measurements of the sound-speed profile in the bubbly wake formed by a small motor boat

    NASA Astrophysics Data System (ADS)

    Vagle, Svein; Burch, Holly

    2005-01-01

    In situ measurements of the bubble field within wakes generated by a small motorboat show that the bubble field, shortly after the initial turbulent generation period, consists mainly of bubbles with radii between 20 and 200 μm. The subsequent dispersion of the wake field can be described using a model that includes bubble buoyancy and dissolution only, and the air volume fraction within the wakes decay exponentially with an e-folding time of between 40 and 60 s. Simultaneous measurements of sound propagating through the bubbly wake exhibit spectral banding due to waveguide propagation. Inversions using the inverse-square theory developed by Buckingham [Philos. Trans. R. Soc. London, Ser. A 335, 513-555 (1991)] show that this acoustic inversion technique provide a viable means of estimating the low-frequency sound-speed profile in an upward refractive bubble layer when dispersion can be neglected. .

  14. Initial growth of sonochemically active and sonoluminescence bubbles at various frequencies.

    PubMed

    Babgi, Bandar; Zhou, Meifang; Aksu, Mecit; Alghamdi, Yousef; Ashokkumar, Muthupandian

    2016-03-01

    The initial growth of acoustic cavitation activity is important in some applications such as therapeutic and diagnostic medicine. The initial growth of cavitation activity has been investigated using sonoluminescence and sonochemical activity (sonochemiluminescence) at 358 kHz, 647 kHz and 1062 kHz and at 5 W, 15 W and 30 W applied power levels. The growth of sonochemically active bubble population is found to be much faster than that of sonoluminescence bubble population at 358 kHz and 647 kHz whereas almost similar growth rate is observed at 1062 kHz for both bubble populations. This suggests that the cavitation bubble resonance size ranges of sonoluminescence and sonochemically active bubbles are different at 358 kHz and 647 kHz, whereas they have similar size range at 1062 kHz. At 358 kHz and 647 kHz, relatively smaller bubbles become chemically active. Possible reasons for such observations have been discussed. The data presented and discussed in this study may be useful in controlling the growth of cavitation bubble population in addition to enhancing the knowledge base in cavitation science. PMID:26584984

  15. Two-bubble acoustic tweezing cytometry for biomechanical probing and stimulation of cells.

    PubMed

    Chen, Di; Sun, Yubing; Gudur, Madhu S R; Hsiao, Yi-Sing; Wu, Ziqi; Fu, Jianping; Deng, Cheri X

    2015-01-01

    The study of mechanotransduction relies on tools that are capable of applying mechanical forces to elicit and assess cellular responses. Here we report a new (to our knowledge) technique, called two-bubble acoustic tweezing cytometry (TB-ATC), for generating spatiotemporally controlled subcellular mechanical forces on live cells by acoustic actuation of paired microbubbles targeted to the cell adhesion receptor integrin. By measuring the ultrasound-induced activities of cell-bound microbubbles and the actin cytoskeleton contractile force responses, we determine that TB-ATC elicits mechanoresponsive cellular changes via cyclic, paired displacements of integrin-bound microbubbles driven by the attractive secondary acoustic radiation force (sARF) between the bubbles in an ultrasound field. We demonstrate the feasibility of dual-mode TB-ATC for both subcellular probing and mechanical stimulation. By exploiting the robust and unique interaction of ultrasound with microbubbles, TB-ATC provides distinct advantages for experimentation and quantification of applied forces and cellular responses for biomechanical probing and stimulation of cells.

  16. Two-Bubble Acoustic Tweezing Cytometry for Biomechanical Probing and Stimulation of Cells

    PubMed Central

    Chen, Di; Sun, Yubing; Gudur, Madhu S.R.; Hsiao, Yi-Sing; Wu, Ziqi; Fu, Jianping; Deng, Cheri X.

    2015-01-01

    The study of mechanotransduction relies on tools that are capable of applying mechanical forces to elicit and assess cellular responses. Here we report a new (to our knowledge) technique, called two-bubble acoustic tweezing cytometry (TB-ATC), for generating spatiotemporally controlled subcellular mechanical forces on live cells by acoustic actuation of paired microbubbles targeted to the cell adhesion receptor integrin. By measuring the ultrasound-induced activities of cell-bound microbubbles and the actin cytoskeleton contractile force responses, we determine that TB-ATC elicits mechanoresponsive cellular changes via cyclic, paired displacements of integrin-bound microbubbles driven by the attractive secondary acoustic radiation force (sARF) between the bubbles in an ultrasound field. We demonstrate the feasibility of dual-mode TB-ATC for both subcellular probing and mechanical stimulation. By exploiting the robust and unique interaction of ultrasound with microbubbles, TB-ATC provides distinct advantages for experimentation and quantification of applied forces and cellular responses for biomechanical probing and stimulation of cells. PMID:25564850

  17. The secondary Bjerknes force between two gas bubbles under dual-frequency acoustic excitation.

    PubMed

    Zhang, Yuning; Zhang, Yuning; Li, Shengcai

    2016-03-01

    The secondary Bjerknes force is one of the essential mechanisms of mutual interactions between bubbles oscillating in a sound field. The dual-frequency acoustic excitation has been applied in several fields such as sonochemistry, biomedicine and material engineering. In this paper, the secondary Bjerknes force under dual-frequency excitation is investigated both analytically and numerically within a large parameter zone. The unique characteristics (i.e., the complicated patterns of the parameter zone for sign change and the combination resonances) of the secondary Bjerknes force under dual-frequency excitation are revealed. Moreover, the influence of several parameters (e.g., the pressure amplitude, the bubble distance and the phase difference between sound waves) on the secondary Bjerknes force is also investigated numerically.

  18. The size of active bubbles for the production of hydrogen in sonochemical reaction field.

    PubMed

    Merouani, Slimane; Hamdaoui, Oualid

    2016-09-01

    The sonication of aqueous solution generates microscopic cavitation bubbles that may growth and violently collapse to produce highly reactive species (i.e. OH, HO2 and H2O2), hydrogen and emit light, sonoluminescence. The bubble size is a key parameter that influences the chemical activity of the system. This wok aims to study theoretically the size of active bubbles for the production of hydrogen in ultrasonic cavitation field in water using a single bubble sonochemistry model. The effect of several parameters such as frequency of ultrasound, acoustic intensity and liquid temperature on the range of sonochemically active bubbles for the production of hydrogen was clarified. The numerical simulation results showed that the size of active bubbles is an interval which includes an optimum value at which the production rate of H2 is maximal. It was shown that the range of ambient radius for an active bubble as well as the optimum bubble radius for the production of hydrogen increased with increasing acoustic intensity and decreased with increasing ultrasound frequency and bulk liquid temperature. It was found that the range of ambient bubble radius dependence of the operational conditions followed the same trend as those reported experimentally for sonoluminescing bubbles. Comparison with literature data showed a good agreement between the theoretical determined optimum bubble sizes for the production of hydrogen and the experimental reported sizes for sonoluminescing bubbles. PMID:27150777

  19. The size of active bubbles for the production of hydrogen in sonochemical reaction field.

    PubMed

    Merouani, Slimane; Hamdaoui, Oualid

    2016-09-01

    The sonication of aqueous solution generates microscopic cavitation bubbles that may growth and violently collapse to produce highly reactive species (i.e. OH, HO2 and H2O2), hydrogen and emit light, sonoluminescence. The bubble size is a key parameter that influences the chemical activity of the system. This wok aims to study theoretically the size of active bubbles for the production of hydrogen in ultrasonic cavitation field in water using a single bubble sonochemistry model. The effect of several parameters such as frequency of ultrasound, acoustic intensity and liquid temperature on the range of sonochemically active bubbles for the production of hydrogen was clarified. The numerical simulation results showed that the size of active bubbles is an interval which includes an optimum value at which the production rate of H2 is maximal. It was shown that the range of ambient radius for an active bubble as well as the optimum bubble radius for the production of hydrogen increased with increasing acoustic intensity and decreased with increasing ultrasound frequency and bulk liquid temperature. It was found that the range of ambient bubble radius dependence of the operational conditions followed the same trend as those reported experimentally for sonoluminescing bubbles. Comparison with literature data showed a good agreement between the theoretical determined optimum bubble sizes for the production of hydrogen and the experimental reported sizes for sonoluminescing bubbles.

  20. Histotripsy-Induced Cavitation Cloud Initiation Thresholds in Tissues of Different Mechanical Properties

    PubMed Central

    Vlaisavljevich, Eli; Maxwell, Adam; Warnez, Matthew; Johnsen, Eric; Cain, Charles A.; Xu, Zhen

    2014-01-01

    Histotripsy is an ultrasound ablation method that depends on the initiation and maintenance of a cavitation bubble cloud to fractionate soft tissue. This paper studies how tissue properties impact the pressure threshold to initiate the cavitation bubble cloud. Our previous study showed that shock scattering off one or more initial bubbles, expanded to sufficient size in the focus, plays an important role in initiating a dense cavitation cloud. In this process, the shock scattering causes the positive pressure phase to be inverted, resulting in a scattered wave that has the opposite polarity of the incident shock. The inverted shock is superimposed on the incident negative pressure phase to form extremely high negative pressures, resulting in a dense cavitation cloud growing toward the transducer. We hypothesize that increased tissue stiffness impedes the expansion of initial bubbles, reducing the scattered tensile pressure, and thus requiring higher initial intensities for cloud initiation. To test this hypothesis, 5-cycle histotripsy pulses at pulse repetition frequencies (PRFs) of 10, 100, or 1000 Hz were applied by a 1-MHz transducer focused inside mechanically tunable tissue-mimicking agarose phantoms and various ex vivo porcine tissues covering a range of Young’s moduli. The threshold to initiate a cavitation cloud and resulting bubble expansion were recorded using acoustic backscatter detection and optical imaging. In both phantoms and ex vivo tissue, results demonstrated a higher cavitation cloud initiation threshold for tissues of higher Young’s modulus. Results also demonstrated a decrease in bubble expansion in phantoms of higher Young’s modulus. These results support our hypothesis, improve our understanding of the effect of histotripsy in tissues with different mechanical properties, and provide a rational basis to tailor acoustic parameters for fractionation of specific tissues. PMID:24474139

  1. Histotripsy-induced cavitation cloud initiation thresholds in tissues of different mechanical properties.

    PubMed

    Vlaisavljevich, Eli; Maxwell, Adam; Warnez, Matthew; Johnsen, Eric; Cain, Charles A; Xu, Zhen

    2014-02-01

    Histotripsy is an ultrasound ablation method that depends on the initiation and maintenance of a cavitation bubble cloud to fractionate soft tissue. This paper studies how tissue properties impact the pressure threshold to initiate the cavitation bubble cloud. Our previous study showed that shock scattering off one or more initial bubbles, expanded to sufficient size in the focus, plays an important role in initiating a dense cavitation cloud. In this process, the shock scattering causes the positive pressure phase to be inverted, resulting in a scattered wave that has the opposite polarity of the incident shock. The inverted shock is superimposed on the incident negative pressure phase to form extremely high negative pressures, resulting in a dense cavitation cloud growing toward the transducer. We hypothesize that increased tissue stiffness impedes the expansion of initial bubbles, reducing the scattered tensile pressure, and thus requiring higher initial intensities for cloud initiation. To test this hypothesis, 5-cycle histotripsy pulses at pulse repetition frequencies (PRFs) of 10, 100, or 1000 Hz were applied by a 1-MHz transducer focused inside mechanically tunable tissue-mimicking agarose phantoms and various ex vivo porcine tissues covering a range of Young's moduli. The threshold to initiate a cavitation cloud and resulting bubble expansion were recorded using acoustic backscatter detection and optical imaging. In both phantoms and ex vivo tissue, results demonstrated a higher cavitation cloud initiation threshold for tissues of higher Young's modulus. Results also demonstrated a decrease in bubble expansion in phantoms of higher Young's modulus. These results support our hypothesis, improve our understanding of the effect of histotripsy in tissues with different mechanical properties, and provide a rational basis to tailor acoustic parameters for fractionation of specific tissues.

  2. Acoustofluidics 16: acoustics streaming near liquid-gas interfaces: drops and bubbles.

    PubMed

    Sadhal, S S

    2012-08-21

    In this sixteenth part of the series on "Acoustofluidics-exploiting ultrasonic standing waves forces and acoustic streaming in microfluidic systems for cell and particle manipulation," we continue our discussion on the analytical aspects of the streaming phenomenon. In particular, the use of the singular perturbation technique for this class of problems is delineated with a set of examples where fluid-fluid interaction takes place. In this category, we focus on drops and bubbles, and deal specifically with the effect of interfacial mobility on the streaming flow. PMID:22776990

  3. Acoustic backscatter properties of the particle/bubble ultrasound contrast agent.

    PubMed

    Phillips, D; Chen, X; Baggs, R; Rubens, D; Violante, M; Parker, K J

    1998-07-01

    Bubble-based suspensions with diameters in the 1-5 microns range have been developed for use as ultrasound contrast agents. Bubbles of these dimensions have resonance frequencies in the diagnostic ultrasonic range, thus improving their backscatter enhancement capabilities. The durability of these bubbles in the blood stream has been found to be limited, providing impetus for a number of approaches to further stabilize them. One of the approaches has been the development of micrometer-size porous particles or 'nano-sponges' with properties suitable for the entrapment and stabilization of gas bubbles. However, the complex morphology and surface chemistry involved in the production of this type of agent makes it unfeasible to directly measure the volume of the entrained gas. A model based on acoustic scattering principles is proposed which indicates that only a small volume fraction of gas should be necessary to significantly enhance the echogenicity of this type of particle-based contrast agent. In the model, the effective scattering cross-section is evaluated as a function of the volume fraction of gas contained in the overall scatterer and the overall scatterer diameter. Initially, the volume fraction of gas is considered as a discrete entity of single bubble. Using common mixture rules, it is then shown that the gas can be considered to be distributed throughout the particle and still arrive at a result that is similar to that for a single, discrete volume of gas. The main contribution to the increased scattering cross-section is due to the compressibility difference between gas and water. The backscatter coefficient is computed as the product of the resulting differential scattering cross-section and the scatterer number density. This approach facilitates comparison with known backscatter coefficients of biological targets such as liver and blood. Simple experimental results are presented for comparison with the model, and the implications relevant to clinical

  4. Investigation of a Method to Reduce Cavitation in Diesel Engine Bearings

    NASA Technical Reports Server (NTRS)

    Keith, Theo G., Jr.; Honaker, Robert W.

    1998-01-01

    Sonoluminescence is the effect of producing light from sound and occurs when a gas bubble is trapped in a fluid filled cavity and is forced to collapse under a barrage of sound waves. Frenzel and Schultes discovered this phenomenon in 1934 while exposing acoustic waves to photographic plates. This effect was not well understood until 1988 when Crum and Gaitan discovered the necessary conditions for producing single bubble sonoluminescence in the laboratory. The luminescence is a result of the bubble violently collapsing from sound waves and this shares a close association with vibratory cavitation. Cavitation erosion is known to cause damage to rotational machinery when the collapse is near to surfaces due to the high pressures associated with bubble collapse. With these high pressures and temperatures there is a considerable amount of damage to the outside layer of a bearing, thereby, reducing its useful life. An experiment was constructed to generate sonoluminescence in the laboratory in order to obtain a greater understanding of this phenomenon and its association with bubble cavitation. Most of the research was done to investigate how to obtain single bubble sonoluminescence under different conditions and to determine how to detect it. Success in this has inspired several theories on how to use the methods for generating sonoluminescence to control cavitation in fluids under industrial conditions.

  5. Sound scattering from rough bubbly ocean surface based on modified sea surface acoustic simulator and consideration of various incident angles and sub-surface bubbles' radii

    NASA Astrophysics Data System (ADS)

    Bolghasi, Alireza; Ghadimi, Parviz; Chekab, Mohammad A. Feizi

    2016-09-01

    The aim of the present study is to improve the capabilities and precision of a recently introduced Sea Surface Acoustic Simulator (SSAS) developed based on optimization of the Helmholtz-Kirchhoff-Fresnel (HKF) method. The improved acoustic simulator, hereby known as the Modified SSAS (MSSAS), is capable of determining sound scattering from the sea surface and includes an extended Hall-Novarini model and optimized HKF method. The extended Hall-Novarini model is used for considering the effects of sub-surface bubbles over a wider range of radii of sub-surface bubbles compared to the previous SSAS version. Furthermore, MSSAS has the capability of making a three-dimensional simulation of scattered sound from the rough bubbly sea surface with less error than that of the Critical Sea Tests (CST) experiments. Also, it presents scattered pressure levels from the rough bubbly sea surface based on various incident angles of sound. Wind speed, frequency, incident angle, and pressure level of the sound source are considered as input data, and scattered pressure levels and scattering coefficients are provided. Finally, different parametric studies were conducted on wind speeds, frequencies, and incident angles to indicate that MSSAS is quite capable of simulating sound scattering from the rough bubbly sea surface, according to the scattering mechanisms determined by Ogden and Erskine. Therefore, it is concluded that MSSAS is valid for both scattering mechanisms and the transition region between them that are defined by Ogden and Erskine.

  6. Sound scattering from rough bubbly ocean surface based on modified sea surface acoustic simulator and consideration of various incident angles and sub-surface bubbles' radii

    NASA Astrophysics Data System (ADS)

    Bolghasi, Alireza; Ghadimi, Parviz; Chekab, Mohammad A. Feizi

    2016-08-01

    The aim of the present study is to improve the capabilities and precision of a recently introduced Sea Surface Acoustic Simulator (SSAS) developed based on optimization of the Helmholtz-Kirchhoff-Fresnel (HKF) method. The improved acoustic simulator, hereby known as the Modified SSAS (MSSAS), is capable of determining sound scattering from the sea surface and includes an extended Hall-Novarini model and optimized HKF method. The extended Hall-Novarini model is used for considering the effects of sub-surface bubbles over a wider range of radii of sub-surface bubbles compared to the previous SSAS version. Furthermore, MSSAS has the capability of making a three-dimensional simulation of scattered sound from the rough bubbly sea surface with less error than that of the Critical Sea Tests (CST) experiments. Also, it presents scattered pressure levels from the rough bubbly sea surface based on various incident angles of sound. Wind speed, frequency, incident angle, and pressure level of the sound source are considered as input data, and scattered pressure levels and scattering coefficients are provided. Finally, different parametric studies were conducted on wind speeds, frequencies, and incident angles to indicate that MSSAS is quite capable of simulating sound scattering from the rough bubbly sea surface, according to the scattering mechanisms determined by Ogden and Erskine. Therefore, it is concluded that MSSAS is valid for both scattering mechanisms and the transition region between them that are defined by Ogden and Erskine.

  7. Acoustic cavitation-mediated delivery of small interfering ribonucleic acids with phase-shift nanoemulsions

    PubMed Central

    Burgess, Mark T.; Porter, Tyrone M.

    2015-01-01

    Localized, targeted delivery of small interfering ribonucleic acid (siRNA) has been the foremost hurdle in the use of siRNA for the treatment of various diseases. Major advances have been achieved in the synthesis of siRNA, which has led to greater target messenger RNA (mRNA) silencing and stability in physiological conditions. Although numerous delivery strategies have shown promise, there are still limited options for targeted delivery and release of siRNA administered systemically. In this in vitro study, phase-shift nanoemulsions (PSNE) were explored as cavitation nuclei to facilitate free siRNA delivery to cancer cells via sonoporation. A cell suspension containing varying amounts of PSNE and siRNA was exposed to 5 MHz pulsed ultrasound at fixed settings (6.2 MPa peak negative pressure, 5 cycle pulses, 250 Hz pulse repetition frequency, and total exposure duration of 100 seconds). Inertial cavitation emissions were detected throughout the exposure using a passive cavitation detector. Successful siRNA delivery was achieved (i.e. > 50% cell uptake) with high viability (> 80% viability). The percentage of cells with siRNA uptake was correlated with the amount of inertial cavitation activity generated from vaporized PSNE. The siRNA remained functional after delivery, significantly reducing expression of green fluorescent protein (GFP) in a stably transfected cell line. These results show that vaporized PSNE can facilitate siRNA entry into the cytosol of a majority of sonicated cells and may provide a non-endosomal route for siRNA delivery. PMID:25979417

  8. Nonlinear Acoustics in Fluids

    NASA Astrophysics Data System (ADS)

    Lauterborn, Werner; Kurz, Thomas; Akhatov, Iskander

    At high sound intensities or long propagation distances at in fluids sufficiently low damping acoustic phenomena become nonlinear. This chapter focuses on nonlinear acoustic wave properties in gases and liquids. The origin of nonlinearity, equations of state, simple nonlinear waves, nonlinear acoustic wave equations, shock-wave formation, and interaction of waves are presented and discussed. Tables are given for the nonlinearity parameter B/A for water and a range of organic liquids, liquid metals and gases. Acoustic cavitation with its nonlinear bubble oscillations, pattern formation and sonoluminescence (light from sound) are modern examples of nonlinear acoustics. The language of nonlinear dynamics needed for understanding chaotic dynamics and acoustic chaotic systems is introduced.

  9. The role of large bubbles detected from acoustic measurements on the dynamics of Erta 'Ale lava lake (Ethiopia)

    NASA Astrophysics Data System (ADS)

    Bouche, E.; Vergniolle, S.; Staudacher, T.; Nercessian, A.; Delmont, J.-C.; Frogneux, M.; Cartault, F.; Le Pichon, A.

    2010-06-01

    The activity at the surface of the lava lake on Erta 'Ale volcano (Ethiopia) shows that large bubbles are regularly breaking at a fixed position on the lava lake. This is also where the small lava fountains are sometimes produced. Since this location is likely to be directly above the volcanic conduit feeding the lava lake, we have done continuous measurements between March 22 and 26, 2003 to understand the degassing of a volcano in permanent activity. The bubble size has been first estimated from videos, which once combined with the acoustic pressure, can constrain the source of the sound. The gas volume and overpressure stayed roughly constant, between 36-700 m3 and 4 × 103-1.8 × 104 Pa, respectively. Simultaneous thermal measurements showed regular peaks, which occurred when the crust was broken by a large bubble, hence gave a direct indication on the typical return time between the bubbles (1 h). These spherical cap bubbles had a high Reynolds number, 4600-20000, therefore a wake, periodically unstable, formed and detached from the bubble bottom. The bubbly wake, if the detachment occurs close to the surface, can explain the duration of lava fountains, measured on the videos. The periodic arrival of bubbly wakes, which mostly detach from the driving spherical cap within the lava lake, could explain the absence of cooling at Erta 'Ale, Erebus (Antartica), Villarica (Chile) and Nyiragongo (Democratic Republic of Congo) without invoking a convective downflow of magma in the conduit, as previously done.

  10. Exploring the Acoustic Parameter Space in Ultrasound Therapy: Defining the Threshold for Cavitational Effects

    NASA Astrophysics Data System (ADS)

    Kieran, Kathleen; Hall, Timothy L.; Parsons, Jessica E.; Wolf, J. Stuart; Fowlkes, J. Brian; Cain, Charles A.; Roberts, William W.

    2007-05-01

    Focused ultrasound energy is capable of noninvasively, nonthermally ablating tissue. However, the relative contributions of thermal and cavitational effects in the therapeutic use of ultrasound are poorly understood. We sought to identify the ultrasound parameter space within which tissue can be ablated by solely mechanical means (cavitation), without a significant thermal component. Methods: Ultrasound energy (750 kHz, 20 microsecond pulses) was applied sequentially in a 3×3 grid configuration to the cortical tissue of ex vivo porcine kidneys submerged in degassed water. While maintaining constant energy density, intensity (0.11-211 kW/cm2) and duty cycle (0.04%-CW) were varied widely. A thermocouple co-localized with the center of each grid provided continuous temperature measurements. Following ablations, the kidneys were examined grossly and histologically. Results: Ablated tissue was classified into one of four discrete morphologic categories: blanched (firm, pale, desiccated tissue), disrupted (cavity containing thin, isochromatic liquid; no blanching), mixed blanched/disrupted (cavity containing pale, thick liquid; minimal blanching), and no grossly visible effect. Morphologically similar lesions clustered together within the ultrasound parameter space. Disrupted lesions had significantly lower maximal temperatures (44.2 °C) than desiccated (67.5 °C; p<0.0001) or mixed (59.4 °C; p<0.0001) lesions. Conclusions: In an ex vivo model, we have defined the ultrasound parameters within which mechanical tissue ablation, with minimal thermal components, is possible. Future research in vivo is directed toward optimizing the parameters for cavitational tissue ablation, and better understanding the impact of tissue perfusion on lesion generation and intralesional temperature rise.

  11. A New Unsteady Model for Dense Cloud Cavitation in Cryogenic Fluids

    NASA Technical Reports Server (NTRS)

    Hosangadi, A.; Ahuja, V.

    2005-01-01

    A new unsteady, cavitation model is presented wherein the phase change process (bubble growth/collapse) is coupled to the acoustic field in a cryogenic fluid. It predicts the number density and radius of bubbles in vapor clouds by tracking both the aggregate surface area and volume fraction of the cloud. Hence, formulations for the dynamics of individual bubbles (e.g. Rayleigh-Plesset equation) may be integrated within the macroscopic context of a dense vapor cloud i.e. a cloud that occupies a significant fraction of available volume and contains numerous bubbles. This formulation has been implemented within the CRUNCH CFD, which has a compressible real fluid formulation, a multi-element, unstructured grid framework, and has been validated extensively for liquid rocket turbopump inducers. Detailed unsteady simulations of a cavitating ogive in liquid nitrogen are presented where time-averaged mean cavity pressure and temperature depressions due to cavitation are compared with experimental data. The model also provides the spatial and temporal history of the bubble size distribution in the vapor clouds that are shed, an important physical parameter that is difficult to measure experimentally and is a significant advancement in the modeling of dense cloud cavitation.

  12. Trapping of embolic particles in a vessel phantom by cavitation-enhanced acoustic streaming

    NASA Astrophysics Data System (ADS)

    Maxwell, Adam D.; Park, Simone; Vaughan, Benjamin L.; Cain, Charles A.; Grotberg, James B.; Xu, Zhen

    2014-09-01

    Cavitation clouds generated by short, high-amplitude, focused ultrasound pulses were previously observed to attract, trap, and erode thrombus fragments in a vessel phantom. This phenomenon may offer a noninvasive method to capture and eliminate embolic fragments flowing through the bloodstream during a cardiovascular intervention. In this article, the mechanism of embolus trapping was explored by particle image velocimetry (PIV). PIV was used to examine the fluid streaming patterns generated by ultrasound in a vessel phantom with and without crossflow of blood-mimicking fluid. Cavitation enhanced streaming, which generated fluid vortices adjacent to the focus. The focal streaming velocity, uf, was as high as 120 cm/s, while mean crossflow velocities, uc, were imposed up to 14 cm/s. When a solid particle 3-4 mm diameter was introduced into crossflow, it was trapped near the focus. Increasing uf promoted particle trapping while increasing uc promoted particle escape. The maximum crossflow Reynolds number at which particles could be trapped, Rec, was approximately linear with focal streaming number, Ref, i.e. Rec = 0.25Ref + 67.44 (R2 = 0.76) corresponding to dimensional velocities uc = 0.084uf + 3.122 for 20 < uf < 120 cm/s. The fluidic pressure map was estimated from PIV and indicated a negative pressure gradient towards the focus, trapping the embolus near this location.

  13. Trapping of embolic particles in a vessel phantom by cavitation-enhanced acoustic streaming.

    PubMed

    Maxwell, Adam D; Park, Simone; Vaughan, Benjamin L; Cain, Charles A; Grotberg, James B; Xu, Zhen

    2014-09-01

    Cavitation clouds generated by short, high-amplitude, focused ultrasound pulses were previously observed to attract, trap, and erode thrombus fragments in a vessel phantom. This phenomenon may offer a noninvasive method to capture and eliminate embolic fragments flowing through the bloodstream during a cardiovascular intervention. In this article, the mechanism of embolus trapping was explored by particle image velocimetry (PIV). PIV was used to examine the fluid streaming patterns generated by ultrasound in a vessel phantom with and without crossflow of blood-mimicking fluid. Cavitation enhanced streaming, which generated fluid vortices adjacent to the focus. The focal streaming velocity, uf, was as high as 120 cm/s, while mean crossflow velocities, uc, were imposed up to 14 cm/s. When a solid particle 3-4 mm diameter was introduced into crossflow, it was trapped near the focus. Increasing uf promoted particle trapping while increasing uc promoted particle escape. The maximum crossflow Reynolds number at which particles could be trapped, Rec, was approximately linear with focal streaming number, Ref, i.e. Rec = 0.25Ref + 67.44 (R(2) = 0.76) corresponding to dimensional velocities uc = 0.084uf + 3.122 for 20 < uf < 120 cm/s. The fluidic pressure map was estimated from PIV and indicated a negative pressure gradient towards the focus, trapping the embolus near this location.

  14. Trapping of Embolic Particles in a Vessel Phantom by Cavitation-Enhanced Acoustic Streaming

    PubMed Central

    Maxwell, Adam D.; Park, Simone; Vaughan, Benjamin L.; Cain, Charles A.; Grotberg, James B.; Xu, Zhen

    2014-01-01

    Cavitation clouds generated by short, high-amplitude, focused ultrasound pulses were previously observed to attract, trap, and erode thrombus fragments in a vessel phantom. This phenomenon may offer a noninvasive method to capture and eliminate embolic fragments flowing through the bloodstream during a cardiovascular intervention. In this article, the mechanism of embolus trapping was explored by particle image velocimetry (PIV). PIV was used to examine the fluid streaming patterns generated by ultrasound in a vessel phantom with and without crossflow of blood-mimicking fluid. Cavitation enhanced streaming, which generated fluid vortices adjacent to the focus. The focal streaming velocity, uf, was as high as 120 cm/s, while mean crossflow velocities, uc, were imposed up to 14 cm/s. When a solid particle 3-4 mm diameter was introduced into crossflow, it was trapped near the focus. Increasing uf promoted particle trapping while increasing uc promoted particle escape. The maximum crossflow Reynolds number at which particles could be trapped, Rec, was approximately linear with focal streaming number, Ref, i.e. Rec = 0.25Ref + 67.44 (R2=0.76) corresponding to dimensional velocities uc=0.084uf + 3.122 for 20 < uf < 120 cm/s. The fluidic pressure map was estimated from PIV and indicated a negative pressure gradient towards the focus, trapping the embolus near this location. PMID:25109407

  15. Cavitation in ultrasound and shockwave therapy

    NASA Astrophysics Data System (ADS)

    Colonius, Tim

    2014-11-01

    Acoustic waves, especially high-intensity ultrasound and shock waves, are used for medical imaging and intra- and extra-corporeal manipulation of cells, tissue, and urinary calculi. Waves are currently used to treat kidney stone disease, plantar fasciitis, and bone nonunion, and they are being investigated as a technique to ablate cancer tumors and mediate drug delivery. In many applications, acoustic waves induce the expansion and collapse of preexisting or newly cavitating bubbles whose presence can either mediate the generation of localized stresses or lead to collateral damage, depending on how effectively they can be controlled. We describe efforts aimed at simulating the collapse of bubbles, both individually and in clusters, with the aim to characterize the induced mechanical stresses and strains. To simulate collapse of one or a few bubbles, compressible Euler and Navier-Stokes simulations of multi-component materials are performed with WENO-based shock and interface capturing schemes. Repetitive insonification generates numerous bubbles that are difficult to resolve numerically. Such clouds are also important in traditional engineering applications such as caveating hydrofoils. Models that incorporate the dynamics of an unresolved dispersed phase consisting of the bubble cloud are also developed. The results of several model problems including bubble collapse near rigid surfaces, bubble collapse near compliant surfaces and in small capillaries are analyzed. The results are processed to determine the potential for micron-sized preexisting gas bubbles to damage capillaries. The translation of the fundamental fluid dynamics into improvements in the design and clinical application of shockwave lithotripters will be discussed. NIH Grant PO1-DK043881.

  16. An electrochemical and high-speed imaging study of micropore decontamination by acoustic bubble entrapment.

    PubMed

    Offin, Douglas G; Birkin, Peter R; Leighton, Timothy G

    2014-03-14

    Electrochemical and high-speed imaging techniques are used to study the abilities of ultrasonically-activated bubbles to clean out micropores. Cylindrical pores with dimensions (diameter × depth) of 500 μm × 400 μm (aspect ratio 0.8), 125 μm × 350 μm (aspect ratio 2.8) and 50 μm × 200 μm (aspect ratio 4.0) are fabricated in glass substrates. Each pore is contaminated by filling it with an electrochemically inactive blocking organic material (thickened methyl salicylate) before the substrate is placed in a solution containing an electroactive species (Fe(CN)6(3-)). An electrode is fabricated at the base of each pore and the Faradaic current is used to monitor the decontamination as a function of time. For the largest pore, decontamination driven by ultrasound (generated by a horn type transducer) and bulk fluid flow are compared. It is shown that ultrasound is much more effective than flow alone, and that bulk fluid flow at the rates used cannot decontaminate the pore completely, but that ultrasound can. In the case of the 125 μm pore, high-speed imaging is used to elucidate the cleaning mechanisms involved in ultrasonic decontamination and reveals that acoustic bubble entrapment is a key feature. The smallest pore is used to explore the limits of decontamination and it is found that ultrasound is still effective at this size under the conditions employed.

  17. Osmotic pressure-triggered cavitation in microcapsules.

    PubMed

    Shang, Luoran; Cheng, Yao; Wang, Jie; Yu, Yunru; Zhao, Yuanjin; Chen, Yongping; Gu, Zhongze

    2016-01-21

    A cavitation system was found in solid microcapsules with a membrane shell and a liquid core. By simply treating these microcapsules with hypertonic solutions, cavitation could be controllably triggered without special equipment or complex operations. A cavitation-formed vapor bubble was fully entrapped within the microcapsules, thus providing an advantageous method for fabricating encapsulated microbubbles with controllable dimensions and functional components. PMID:26659708

  18. Xylem cavitation resistance can be estimated based on time-dependent rate of acoustic emissions.

    PubMed

    Nolf, Markus; Beikircher, Barbara; Rosner, Sabine; Nolf, Anton; Mayr, Stefan

    2015-10-01

    Acoustic emission (AE) analysis allows nondestructive monitoring of embolism formation in plant xylem, but signal interpretation and agreement of acoustically measured hydraulic vulnerability with reference hydraulic techniques remain under debate. We compared the hydraulic vulnerability of 16 species and three crop tree cultivars using hydraulic flow measurements and acoustic emission monitoring, proposing the use of time-dependent AE rates as a novel parameter for AE analysis. There was a linear correlation between the water potential (Ψ) at 50% loss of hydraulic conductivity (P50 ) and the Ψ at maximum AE activity (Pmaxrate ), where species with lower P50 also had lower Pmaxrate (P < 0.001, R(2)  = 0.76). Using AE rates instead of cumulative counts for AE analysis allows more efficient estimation of P50 , while excluding problematic AE at late stages of dehydration.

  19. Acoustic Cluster Therapy: In Vitro and Ex Vivo Measurement of Activated Bubble Size Distribution and Temporal Dynamics.

    PubMed

    Healey, Andrew John; Sontum, Per Christian; Kvåle, Svein; Eriksen, Morten; Bendiksen, Ragnar; Tornes, Audun; Østensen, Jonny

    2016-05-01

    Acoustic cluster technology (ACT) is a two-component, microparticle formulation platform being developed for ultrasound-mediated drug delivery. Sonazoid microbubbles, which have a negative surface charge, are mixed with micron-sized perfluoromethylcyclopentane droplets stabilized with a positively charged surface membrane to form microbubble/microdroplet clusters. On exposure to ultrasound, the oil undergoes a phase change to the gaseous state, generating 20- to 40-μm ACT bubbles. An acoustic transmission technique is used to measure absorption and velocity dispersion of the ACT bubbles. An inversion technique computes bubble size population with temporal resolution of seconds. Bubble populations are measured both in vitro and in vivo after activation within the cardiac chambers of a dog model, with catheter-based flow through an extracorporeal measurement flow chamber. Volume-weighted mean diameter in arterial blood after activation in the left ventricle was 22 μm, with no bubbles >44 μm in diameter. After intravenous administration, 24.4% of the oil is activated in the cardiac chambers. PMID:26831341

  20. Acoustic Cluster Therapy: In Vitro and Ex Vivo Measurement of Activated Bubble Size Distribution and Temporal Dynamics.

    PubMed

    Healey, Andrew John; Sontum, Per Christian; Kvåle, Svein; Eriksen, Morten; Bendiksen, Ragnar; Tornes, Audun; Østensen, Jonny

    2016-05-01

    Acoustic cluster technology (ACT) is a two-component, microparticle formulation platform being developed for ultrasound-mediated drug delivery. Sonazoid microbubbles, which have a negative surface charge, are mixed with micron-sized perfluoromethylcyclopentane droplets stabilized with a positively charged surface membrane to form microbubble/microdroplet clusters. On exposure to ultrasound, the oil undergoes a phase change to the gaseous state, generating 20- to 40-μm ACT bubbles. An acoustic transmission technique is used to measure absorption and velocity dispersion of the ACT bubbles. An inversion technique computes bubble size population with temporal resolution of seconds. Bubble populations are measured both in vitro and in vivo after activation within the cardiac chambers of a dog model, with catheter-based flow through an extracorporeal measurement flow chamber. Volume-weighted mean diameter in arterial blood after activation in the left ventricle was 22 μm, with no bubbles >44 μm in diameter. After intravenous administration, 24.4% of the oil is activated in the cardiac chambers.

  1. Suppressing bubble shielding effect in shock wave lithotripsy by low intensity pulsed ultrasound.

    PubMed

    Wang, Jen-Chieh; Zhou, Yufeng

    2015-01-01

    Extracorporeal shock wave lithotripsy (ESWL) has been used as an effective modality to fragment kidney calculi. Because of the bubble shielding effect in the pre-focal region, the acoustic energy delivered to the focus is reduced. Low pulse repetition frequency (PRF) will be applied to dissolve these bubbles for better stone comminution efficiency. In this study, low intensity pulsed ultrasound (LIPUS) beam was aligned perpendicular to the axis of a shock wave (SW) lithotripter at its focus. The light transmission was used to evaluate the compressive wave and cavitation induced by SWs without or with a combination of LIPUS for continuous sonication. It is found that bubble shielding effect becomes dominated with the SW exposure and has a greater significant effect on cavitation than compressive wave. Using the combined wave scheme, the improvement began at the 5th pulse and gradually increased. Suppression effect on bubble shielding is independent on the trigger delay, but increases with the acoustic intensity and pulse duration of LIPUS. The peak negative and integral area of light transmission signal, which present the compressive wave and cavitation respectively, using our strategy at PRF of 1 Hz are comparable to those using SW alone at PRF of 0.1 Hz. In addition, high-speed photography confirmed the bubble activities in both free field and close to a stone surface. Bubble motion in response to the acoustic radiation force by LIPUS was found to be the major mechanism of suppressing bubble shielding effect. There is a 2.6-fold increase in stone fragmentation efficiency after 1000 SWs at PRF of 1 Hz in combination with LIPUS. In summary, combination of SWs and LIPUS is an effective way of suppressing bubble shielding effect and, subsequently, improving cavitation at the focus for a better outcome.

  2. Harness cavitation to improve processing

    SciTech Connect

    Pandit, A.G.; Moholkar, V.S.

    1996-07-01

    Mention cavitation to most chemical engineers, and they undoubtedly think of it as an operational problem. Indeed, the rapid creation and then collapse of bubbles, which is after all what cavitation involves, can destroy pumps and erode other equipment. Cavitation, however, also can have a positive side--presuming it is designed for and not unplanned. In this article, the authors look at how cavitation can be harnessed to improve processes, and the mechanisms for inducing cavitation--ultrasonics and hydrodynamics--and their likely roles. Sonication, that is, the use of ultrasound, is the conventional approach for creating cavitation, and so they turn to it first. Over the past few years, a number of groups have attempted to solve the problem of scale-up and design of ultrasonic reactors. The authors review the systems that already exist and also explore a simpler and efficient alternative to the ultrasonic reactor, the hydrodynamic cavitation reactor.

  3. Bubbles with shock waves and ultrasound: a review.

    PubMed

    Ohl, Siew-Wan; Klaseboer, Evert; Khoo, Boo Cheong

    2015-10-01

    The study of the interaction of bubbles with shock waves and ultrasound is sometimes termed 'acoustic cavitation'. It is of importance in many biomedical applications where sound waves are applied. The use of shock waves and ultrasound in medical treatments is appealing because of their non-invasiveness. In this review, we present a variety of acoustics-bubble interactions, with a focus on shock wave-bubble interaction and bubble cloud phenomena. The dynamics of a single spherically oscillating bubble is rather well understood. However, when there is a nearby surface, the bubble often collapses non-spherically with a high-speed jet. The direction of the jet depends on the 'resistance' of the boundary: the bubble jets towards a rigid boundary, splits up near an elastic boundary, and jets away from a free surface. The presence of a shock wave complicates the bubble dynamics further. We shall discuss both experimental studies using high-speed photography and numerical simulations involving shock wave-bubble interaction. In biomedical applications, instead of a single bubble, often clouds of bubbles appear (consisting of many individual bubbles). The dynamics of such a bubble cloud is even more complex. We shall show some of the phenomena observed in a high-intensity focused ultrasound (HIFU) field. The nonlinear nature of the sound field and the complex inter-bubble interaction in a cloud present challenges to a comprehensive understanding of the physics of the bubble cloud in HIFU. We conclude the article with some comments on the challenges ahead.

  4. Can Cavitation Be Anticipated?

    SciTech Connect

    Allgood, G.O.; Dress, W.B.; Hylton, J.O.; Kercel, S.W.

    1999-04-25

    The major problem with cavitation in pumps and hydraulic systems is that there is no effective (conventional) method for detecting or predicting its inception. The traditional method of recognizing cavitation in a pump is to declare the event occurring when the total head drops by some arbitrary value (typically 3%) in response to a pressure reduction at the pump inlet. However, the device is already seriously cavitating when this happens. What is actually needed is a practical method to detect impending rather than incipient cavitation. Whereas the detection of incipient cavitation requires the detection of features just after cavitation starts, the anticipation of cavitation requires the detection and identification of precursor features just before it begins. Two recent advances that make this detection possible. The first is acoustic sensors with a bandwidth of 1 MHz and a dynamic range of 80 dB that preserve the fine details of the features when subjected to coarse vibrations. The second is the application of Bayesian parameter estimation which makes it possible to separate weak signals, such as those present in cavitation precursors, from strong signals, such as pump vibration. Bayesian parameter estimation derives a model based on cavitation hydrodynamics and produces a figure of merit of how well it fits the acquired data. Applying this model to an anticipatory engine should lead to a reliable method of anticipating cavitation before it occurs. This paper reports the findings of precursor features using high-performance sensors and Bayesian analysis of weak acoustic emissions in the 100-1000kHz band from an experimental flow loop.

  5. A New Unsteady Model for Dense Cloud Cavitation in Cryogenic Fluids

    NASA Technical Reports Server (NTRS)

    Hosangadi, Ashvin; Ahuja, Vineet

    2005-01-01

    Contents include the following: Background on thermal effects in cavitation. Physical properties of hydrogen. Multi-phase cavitation with thermal effect. Solution procedure. Cavitation model overview. Cavitation source terms. New cavitation model. Source term for bubble growth. One equation les model. Unsteady ogive simulations: liquid nitrogen. Unsteady incompressible flow in a pipe. Time averaged cavity length for NACA15 flowfield.

  6. Three types of cavitation caused by air seeding.

    PubMed

    Shen, Fanyi; Wang, Yuansheng; Cheng, Yanxia; Zhang, Li

    2012-11-01

    There are different opinions of the dynamics of an air bubble entering a xylem conduit. In this paper, we present a thorough mechanical analysis and conclude that there are three types of cavitation caused by air seeding. After an air seed enters a conduit at high xylem pressure P'(1), along with the drop of the water potential, it will expand gradually to a long-shaped bubble and extend continually. This is the first type of air seeding, or the type of expanding gradually. When the xylem pressure is moderate, right after an air seed enters a conduit, it will expand first. Then, as soon as the pressure reaches a threshold the bubble will blow up to form a bubble in long shape, accompanied by acoustic (or ultra-acoustic) emission. It will extend further as xylem pressure decreases continually. This is the second type of air seeding, or the type of expanding-exploding, becoming a long-shaped bubble-lengthening by degrees. In the range of P'(1) ≤ - 3P(o) (P(o) is atmospheric pressure), soon after an air seed is sucked into a conduit it will explode immediately and the conduit will be full of the gas of the bubble instantly. This is the third type of air seeding, or the type of sudden exploding and filling conduit instantly. The third type is the frequent event in daily life of plant.

  7. Near resonant bubble acoustic cross-section corrections, including examples from oceanography, volcanology, and biomedical ultrasound.

    PubMed

    Ainslie, Michael A; Leighton, Timothy G

    2009-11-01

    The scattering cross-section sigma(s) of a gas bubble of equilibrium radius R(0) in liquid can be written in the form sigma(s)=4piR(0) (2)[(omega(1) (2)omega(2)-1)(2)+delta(2)], where omega is the excitation frequency, omega(1) is the resonance frequency, and delta is a frequency-dependent dimensionless damping coefficient. A persistent discrepancy in the frequency dependence of the contribution to delta from radiation damping, denoted delta(rad), is identified and resolved, as follows. Wildt's [Physics of Sound in the Sea (Washington, DC, 1946), Chap. 28] pioneering derivation predicts a linear dependence of delta(rad) on frequency, a result which Medwin [Ultrasonics 15, 7-13 (1977)] reproduces using a different method. Weston [Underwater Acoustics, NATO Advanced Study Institute Series Vol. II, 55-88 (1967)], using ostensibly the same method as Wildt, predicts the opposite relationship, i.e., that delta(rad) is inversely proportional to frequency. Weston's version of the derivation of the scattering cross-section is shown here to be the correct one, thus resolving the discrepancy. Further, a correction to Weston's model is derived that amounts to a shift in the resonance frequency. A new, corrected, expression for the extinction cross-section is also derived. The magnitudes of the corrections are illustrated using examples from oceanography, volcanology, planetary acoustics, neutron spallation, and biomedical ultrasound. The corrections become significant when the bulk modulus of the gas is not negligible relative to that of the surrounding liquid.

  8. Cavitating vortex generation by a submerged jet

    SciTech Connect

    Belyakov, G. V.; Filippov, A. N.

    2006-05-15

    The surface geometry of a cavitating vortex is determined in the limit of inviscid incompressible flow. The limit surface is an ovaloid of revolution with an axis ratio of 5: 3. It is shown that a cavitating vortex ring cannot develop if the cavitation number is lower than a certain critical value. Experiments conducted at various liquid pressures and several jet exit velocities confirm the existence of a critical cavitation number close to 3. At cavitation numbers higher than the critical one, the cavitating vortex ring does not develop. At substantially lower cavitation numbers (k {<=} 0.1), an elongated asymmetric cavitation bubble is generated, with an axial reentrant jet whose length can exceed the initial jet length by several times. This flow structure is called an asymmetric cavitating vortex, even though steady motion of this structure has not been observed.

  9. The role of cavitation microjets in the therapeutic applications of ultrasound.

    PubMed

    Brujan, E A

    2004-03-01

    The dynamics of a gas bubble situated in a sound-irradiated liquid and near a rigid boundary was studied theoretically to get a better understanding of the role of cavitation microjets in the therapeutic applications of ultrasound (US). The boundary integral method was adopted to simulate the temporal development of the bubble shape, jet formation during bubble collapse and bubble migration. It was found that the dynamic behaviour of the jet and the migratory characteristics of the bubble depend not only on the distance between bubble and boundary but, also, on the properties of the acoustic field. For frequencies of sound fields smaller than or equal to the resonance frequency of the bubble, jet formation and bubble migration toward the boundary are the main features of the interaction. No jet formation was observed for frequencies of sound fields larger than the resonance frequency of the bubble, and the bubble kept its initial position from the boundary throughout its motion. The pressure generated by the impact of the jet developed during bubble collapse close to the boundary may result in the fragmentation of brittle objects, such as renal calculi, dental tartar or intraocular lens.

  10. Submicron-Bubble-Enhanced Focused Ultrasound for Blood–Brain Barrier Disruption and Improved CNS Drug Delivery

    PubMed Central

    Ting, Chien-Yu; Lee, Ya-Hsuan; Huang, Chih-Ying; Ma, Yan-Jung; Wei, Kuo-Chen; Yen, Tzu-Chen; Yeh, Chih-Kuang

    2014-01-01

    The use of focused ultrasound (FUS) with microbubbles has been proven to induce transient blood–brain barrier opening (BBB-opening). However, FUS-induced inertial cavitation of microbubbles can also result in erythrocyte extravasations. Here we investigated whether induction of submicron bubbles to oscillate at their resonant frequency would reduce inertial cavitation during BBB-opening and thereby eliminate erythrocyte extravasations in a rat brain model. FUS was delivered with acoustic pressures of 0.1–4.5 MPa using either in-house manufactured submicron bubbles or standard SonoVue microbubbles. Wideband and subharmonic emissions from bubbles were used to quantify inertial and stable cavitation, respectively. Erythrocyte extravasations were evaluated by in vivo post-treatment magnetic resonance susceptibility-weighted imaging, and finally by histological confirmation. We found that excitation of submicron bubbles with resonant frequency-matched FUS (10 MHz) can greatly limit inertial cavitation while enhancing stable cavitation. The BBB-opening was mainly caused by stable cavitation, whereas the erythrocyte extravasation was closely correlated with inertial cavitation. Our technique allows extensive reduction of inertial cavitation to induce safe BBB-opening. Furthermore, the safety issue of BBB-opening was not compromised by prolonging FUS exposure time, and the local drug concentrations in the brain tissues were significantly improved to 60 times (BCNU; 18.6 µg versus 0.3 µg) by using chemotherapeutic agent-loaded submicron bubbles with FUS. This study provides important information towards the goal of successfully translating FUS brain drug delivery into clinical use. PMID:24788566

  11. Trans-Stent B-Mode Ultrasound and Passive Cavitation Imaging.

    PubMed

    Haworth, Kevin J; Raymond, Jason L; Radhakrishnan, Kirthi; Moody, Melanie R; Huang, Shao-Ling; Peng, Tao; Shekhar, Himanshu; Klegerman, Melvin E; Kim, Hyunggun; McPherson, David D; Holland, Christy K

    2016-02-01

    Angioplasty and stenting of a stenosed artery enable acute restoration of blood flow. However, restenosis or a lack of re-endothelization can subsequently occur depending on the stent type. Cavitation-mediated drug delivery is a potential therapy for these conditions, but requires that particular types of cavitation be induced by ultrasound insonation. Because of the heterogeneity of tissue and stochastic nature of cavitation, feedback mechanisms are needed to determine whether the sustained bubble activity is induced. The objective of this study was to determine the feasibility of passive cavitation imaging through a metal stent in a flow phantom and an animal model. In this study, an endovascular stent was deployed in a flow phantom and in porcine femoral arteries. Fluorophore-labeled echogenic liposomes, a theragnostic ultrasound contrast agent, were injected proximal to the stent. Cavitation images were obtained by passively recording and beamforming the acoustic emissions from echogenic liposomes insonified with a low-frequency (500 kHz) transducer. In vitro experiments revealed that the signal-to-noise ratio for detecting stable cavitation activity through the stent was greater than 8 dB. The stent did not significantly reduce the signal-to-noise ratio. Trans-stent cavitation activity was also detected in vivo via passive cavitation imaging when echogenic liposomes were insonified by the 500-kHz transducer. When stable cavitation was detected, delivery of the fluorophore into the arterial wall was observed. Increased echogenicity within the stent was also observed when echogenic liposomes were administered. Thus, both B-mode ultrasound imaging and cavitation imaging are feasible in the presence of an endovascular stent in vivo. Demonstration of this capability supports future studies to monitor restenosis with contrast-enhanced ultrasound and pursue image-guided ultrasound-mediated drug delivery to inhibit restenosis.

  12. Multibubble sonoluminescence spectra of water which resemble single-bubble sonoluminescence

    PubMed

    Didenko; Gordeychuk

    2000-06-12

    Multibubble sonoluminescence (MBSL) spectra of water from cavitation clouds were collected in the presence of different noble gases and at different acoustic intensities. Results show that at high acoustic intensity and with xenon as a dissolved gas the emission of the OH* radical becomes indiscernible from the continuum. These spectra resemble single-bubble sonoluminescence (SBSL) spectra. It is concluded that the source of emission in MBSL and SBSL can be the same, the difference in spectra is due to the higher temperature inside the bubble during SBSL.

  13. Numerical simulation of shock and bubble dynamics in shockwave lithotripsy

    NASA Astrophysics Data System (ADS)

    Colonius, Tim; Tanguay, Michel

    2002-11-01

    Theoretical evaluation of the efficacy of stone comminution (and potential for tissue damage) during shockwave lithotripsy requires knowledge of the complex stress fields associated with both the incident focussing shock and the dynamics of cavitation bubbles that it induces. While simple models from geometrical acoustics and subsequent modeling of spherical bubbles in isolation (Gilmore equation) can provide estimates, high-speed photography in vitro reveals a far more complex flow with bubble number densities that are sufficiently high such that collective effects associated with a cloud of bubbles are important. This talk will describe a modeling effort aimed at estimating stresses from these complex lithotripter generated flow fields. We compute the time-dependent, compressible, ensemble-averaged two-phase flow equations with a finite-difference scheme. Detailed modeling of the dynamics of bubbles (on the microscale) and high-order weighted essentially nonoscillatory shock-capturing schemes are employed. The model is compared to hydrophone and passive cavitation detection measurements, as well as qualitative comparison with high-speed photography. Finally, we explore collective bubble mechanisms ranging from defocusing and shielding of the stone (for high bubble densities in the focal region) to enhanced stresses due to concerted cloud collapse in a dual-pulse lithotripsy configuration. [Work supported by NIH P01 DK-43881 and NSF under grant CTS-9979258.

  14. Collapse and rebound of a gas-filled spherical bubble immersed in a diagnostic ultrasonic field.

    PubMed

    Aymé-Bellegarda, E J

    1990-08-01

    This work is concerned with the influence of the finite-amplitude distortion of a driving diagnostic ultrasonic field on the collapse and rebound of a gas-filled spherical microbubble, present in the exposed compressible liquid. Such an analysis is especially important since one of the mechanisms for cavitation damage comes from the very large gas pressures generated at bubble collapse and in the subsequent pressure wave formed by bubble rebound. Gilmore's model [F.R. Gilmore, "The growth or collapse of a spherical bubble in a viscous compressible liquid," Hydrodynamics Lab. Rep. No. 26-4, California Institute of Technology, Pasadena, CA (1952)] for bubble dynamics is used to obtain the motion of the bubble interface when subjected to a pulsed diagnostic ultrasonic field of large amplitude. Knowledge of the bubble motion allows one to derive the pressure distribution around the bubble. Numerical results over a range of initial bubble sizes, acoustic pressures, and frequencies relevant to medical use show that the strength of the pressure spikes radiated by the rebounding bubble depends upon (i) the acoustic frequency (f), (ii) the initial bubble size (R0), and (iii) the magnitude of the pressure amplitude of the fundamental (PF) in a Fourier series description of the distorted pulse. As the pressure spikes propagate outward from the bubble wall, their strength is attenuated as the reciprocal of the distance from the center of collapse.

  15. Measurement of the impuslive force generated by colapsing bubble close to a solid boundary

    NASA Astrophysics Data System (ADS)

    Muller, Milos; Unger, Jiri; Holata, Jakub; Zima, Patrik

    2012-04-01

    The article presents experimental results of the acoustical and optical study of cavitation bubble collapse close to a solid boundary in water. The bubble was generated by discharge of low-voltage capacitor into a couple of wires closing a simple circuit. Different distances from the solid wall and different maximum bubble radii were studied. The bubble radius was studied using time-resolved photography and by PVDF film sensor glued on the solid boundary. The illumination was provided by high-power led diode. Synchronization of the system was provided by pulse generator connected to an oscilloscope. The impact power of the bubble to the wall was estimated from the time-resolved photography of the bubble and from the PVDF film sensor signal. The PVDF film sensor calibration was performed by a pendulum test to estimate the impact force.

  16. Cavitation studies in microgravity

    NASA Astrophysics Data System (ADS)

    Kobel, Philippe; Obreschkow, Danail; Farhat, Mohamed; Dorsaz, Nicolas; de Bosset, Aurele

    The hydrodynamic cavitation phenomenon is a major source of erosion for many industrial systems such as cryogenic pumps for rocket propulsion, fast ship propellers, hydraulic pipelines and turbines. Erosive processes are associated with liquid jets and shockwaves emission fol-lowing the cavity collapse. Yet, fundamental understanding of these processes requires further cavitation studies inside various geometries of liquid volumes, as the bubble dynamics strongly depends the surrounding pressure field. To this end, microgravity represents a unique platform to produce spherical fluid geometries and remove the hydrostatic pressure gradient induced by gravity. The goal of our first experiment (flown on ESA's parabolic flight campaigns 2005 and 2006) was to study single bubble dynamics inside large spherical water drops (having a radius between 8 and 13 mm) produced in microgravity. The water drops were created by a micro-pump that smoothly expelled the liquid through a custom-designed injector tube. Then, the cavitation bubble was generated through a fast electrical discharge between two electrodes immersed in the liquid from above. High-speed imaging allowed to analyze the implications of isolated finite volumes and spherical free surfaces on bubble evolution, liquid jets formation and shock wave dynamics. Of particular interest are the following results: (A) Bubble lifetimes are shorter than in extended liquid volumes, which could be explain by deriving novel corrective terms to the Rayleigh-Plesset equation. (B) Transient crowds of micro-bubbles (smaller than 1mm) appeared at the instants of shockwaves emission. A comparison between high-speed visualizations and 3D N-particle simulations of a shock front inside a liquid sphere reveals that focus zones within the drop lead to a significantly increased density of induced cavitation. Considering shock wave crossing and focusing may hence prove crucially useful to understand the important process of cavitation erosion

  17. Enhanced cavitation by using two consecutive ultrasound waves at different frequencies

    PubMed Central

    Yang, Xinmai; Jo, Janggun

    2014-01-01

    Efficient and noninvasive generation of cavitation bubbles in soft tissue is a challenging task due to the lack of cavitation nuclei (i.e., pre-existing gas bubbles). In this study, we present a method to generate and enhance cavitation activity based on the utilization of two consecutive ultrasound waves at different frequencies. First, a high frequency (5 MHz) high intensity focused ultrasound (HIFU) wave was applied to a tissue-mimicking phantom to induce a rapid temperature rise in the ultrasound focal region. Immediately following the high frequency HIFU wave, a low frequency (1 MHz) HIFU wave was applied to the same focal region to induce acoustic cavitation. We found that cavitation activity was enhanced when the temperature in the tissue-mimicking phantom was first elevated by the high frequency HIFU wave. The enhancement was greater when a higher intensity of high frequency HIFU wave was applied. This result may be due to the temporary super-saturation of air in the initially air-saturated test samples and the reduction of surface tension at an elevated temperature. PMID:25425746

  18. Bubbles with shock waves and ultrasound: a review

    PubMed Central

    Ohl, Siew-Wan; Klaseboer, Evert; Khoo, Boo Cheong

    2015-01-01

    The study of the interaction of bubbles with shock waves and ultrasound is sometimes termed ‘acoustic cavitation'. It is of importance in many biomedical applications where sound waves are applied. The use of shock waves and ultrasound in medical treatments is appealing because of their non-invasiveness. In this review, we present a variety of acoustics–bubble interactions, with a focus on shock wave–bubble interaction and bubble cloud phenomena. The dynamics of a single spherically oscillating bubble is rather well understood. However, when there is a nearby surface, the bubble often collapses non-spherically with a high-speed jet. The direction of the jet depends on the ‘resistance' of the boundary: the bubble jets towards a rigid boundary, splits up near an elastic boundary, and jets away from a free surface. The presence of a shock wave complicates the bubble dynamics further. We shall discuss both experimental studies using high-speed photography and numerical simulations involving shock wave–bubble interaction. In biomedical applications, instead of a single bubble, often clouds of bubbles appear (consisting of many individual bubbles). The dynamics of such a bubble cloud is even more complex. We shall show some of the phenomena observed in a high-intensity focused ultrasound (HIFU) field. The nonlinear nature of the sound field and the complex inter-bubble interaction in a cloud present challenges to a comprehensive understanding of the physics of the bubble cloud in HIFU. We conclude the article with some comments on the challenges ahead. PMID:26442143

  19. Cavitation erosion of silver plated coating at different temperatures and pressures

    SciTech Connect

    Hattori, Shuji; Motoi, Yoshihiro; Kikuta, Kengo; Tomaru, Hiroshi

    2014-04-11

    Cavitation often occurs in inducer pumps used for space rockets. Silver plated coating on the inducer liner faces the damage of cavitation. Therefore, it is important to study about the cavitation erosion resistance for silver plated coating at several operating conditions in the inducer pumps. In this study, the cavitation erosion tests were carried for silver plated coating in deionized water and ethanol at several liquid temperatures (273K–400K) and pressures (0.10MPa–0.48MPa). The mass loss rate is evaluated in terms of thermodynamic parameter Σ proposed by Brennen [9], suppression pressure p–p{sub v} (p{sub v}: saturated vapor pressure) and acoustic impedance ρc (ρ: density and c: sound speed). Cavitation bubble behaviors depending on the thermodynamic effect and the liquid type were observed by high speed video camera. The mass loss rate is formulated by thermodynamic parameter Σ, suppression pressure p–p{sub v} and acoustic impedance ρc.

  20. High speed observation of HIFU-induced cavitation cloud near curved rigid boundaries

    NASA Astrophysics Data System (ADS)

    Zuo, Z. G.; Wang, F. B.; Liu, S. H.; Wu, S. J.

    2015-01-01

    This paper focuses on the experimental study of the influence of surface curvature to the behaviour of HIFU-induced cavitation cloud. A Q-switched ruby pulse laser is used to induce cavitation nuclei in deionized water. A piezoelectric ultrasonic transducer (1.7 MHz) provides a focused ultrasound field to inspire the nucleus to cavitation cloud. A PZT probe type hydrophone is applied for measuring the HIFU sound field. It was observed that the motion of cavitation cloud located near the boundary is significantly influenced by the distance between cloud and boundary, as well as the curvature of the boundary. The curvature was defined by parameters λ and ξ. Convex boundary, concave boundary, and flat boundary correspond to ξ <1, ξ >1 and ξ = 1, respectively. Different behaviours of the cloud, including the migration of the cloud, the characteristics of oscillation, etc., were observed under different boundary curvatures by high-speed photography. Sonoluminescence of the acoustic cavitation bubble clouds were also studied to illustrate the characteristics of acoustic streaming.

  1. Blood vessel rupture by cavitation

    PubMed Central

    Chen, Hong; Brayman, Andrew A.; Bailey, Michael R.

    2011-01-01

    Cavitation is thought to be one mechanism for vessel rupture during shock wave lithotripsy treatment. However, just how cavitation induces vessel rupture remains unknown. In this work, a high-speed photomicrography system was set up to directly observe the dynamics of bubbles inside blood vessels in ex vivo rat mesenteries. Vascular rupture correlating to observed bubble dynamics were examined by imaging bubble extravasation and dye leakage. The high-speed images show that bubble expansion can cause vessel distention, and bubble collapse can lead to vessel invagination. Liquid jets were also observed to form. Our results suggest that all three mechanisms, vessel distention, invagination and liquid jets, can contribute to vessel rupture. PMID:20680255

  2. Properties of sound attenuation around a two-dimensional underwater vehicle with a large cavitation number

    NASA Astrophysics Data System (ADS)

    Ye, Peng-Cheng; Pan, Guang

    2015-06-01

    Due to the high speed of underwater vehicles, cavitation is generated inevitably along with the sound attenuation when the sound signal traverses through the cavity region around the underwater vehicle. The linear wave propagation is studied to obtain the influence of bubbly liquid on the acoustic wave propagation in the cavity region. The sound attenuation coefficient and the sound speed formula of the bubbly liquid are presented. Based on the sound attenuation coefficients with various vapor volume fractions, the attenuation of sound intensity is calculated under large cavitation number conditions. The result shows that the sound intensity attenuation is fairly small in a certain condition. Consequently, the intensity attenuation can be neglected in engineering. Project supported by the National Natural Science Foundation of China (Grant Nos. 51279165 and 51479170) and the National Defense Basic Scientific Research Program of China (Grant No. B2720133014).

  3. Extreme impact and cavitation forces of a biological hammer: strike forces of the peacock mantis shrimp Odontodactylus scyllarus.

    PubMed

    Patek, S N; Caldwell, R L

    2005-10-01

    Mantis shrimp are renowned for their unusual method of breaking shells with brief, powerful strikes of their raptorial appendages. Due to the extreme speeds of these strikes underwater, cavitation occurs between their appendages and hard-shelled prey. Here we examine the magnitude and relative contribution of the impact and cavitation forces generated by the peacock mantis shrimp Odontodactylus scyllarus. We present the surprising finding that each strike generates two brief, high-amplitude force peaks, typically 390-480 micros apart. Based on high-speed imaging, force measurements and acoustic analyses, it is evident that the first force peak is caused by the limb's impact and the second force peak is due to the collapse of cavitation bubbles. Peak limb impact forces range from 400 to 1501 N and peak cavitation forces reach 504 N. Despite their small size, O. scyllarus can generate impact forces thousands of times their body weight. Furthermore, on average, cavitation peak forces are 50% of the limb's impact force, although cavitation forces may exceed the limb impact forces by up to 280%. The rapid succession of high peak forces used by mantis shrimp suggests that mantis shrimp use a potent combination of cavitation forces and extraordinarily high impact forces to fracture shells. The stomatopod's hammer is fundamentally different from typical shell-crushing mechanisms such as fish jaws and lobster claws, and may have played an important and as yet unexamined role in the evolution of shell form. PMID:16169943

  4. Magnetic resonance imaging of velocity fields, the void fraction and gas dynamics in a cavitating liquid

    NASA Astrophysics Data System (ADS)

    Mastikhin, Igor V.; Arbabi, Aidin; Newling, Benedict; Hamza, Abdelhaq; Adair, Alexander

    2012-01-01

    In acoustic cavitation, the relationship between the bubble dynamics on the microscale and the flow properties on the macroscale is critical in determining sonochemical reaction kinetics. A new technique was developed to measure the void fraction and estimate water mobility in the vicinity of cavitating bubbles using phase-encoded magnetic resonance imaging with short characteristic measurement timescales (0.1-1 ms). The exponential behavior of the NMR signal decay indicated the fast diffusion regime, with the relationship between local mechanical dispersion D mix and the average bubble radius R, D_mix≫ 2R^2/10^{-4s}, resulting in dispersion of orders of magnitude greater than diffusion in quiescent water. For two different samples (water and a surfactant solution), the independent measurements of three-dimensional void fraction and velocity fields permitted the calculation of compressibility, divergence and vorticity of the cavitating medium. The measured dynamics of the dissolved gas, compared with that of the surrounding liquid, reflected the difference in the bubble coalescence and lifetimes and correlated with the macroscopic flow parameters.

  5. Sonoluminescence characterization of inertial cavitation inside a BSA phantom treated by pulsed HIFU.

    PubMed

    Yin, Hui; Chang, Nan; Xu, Shanshan; Wan, Mingxi

    2016-09-01

    The aim of this study was to investigate the inertial cavitation inside a phantom treated by pulsed HIFU (pHIFU). Basic bovine serum albumin (BSA) phantoms without any inherent ultrasound contrast agents (UCAs) or phase-shift nano-emulsions (PSNEs) were used. During the treatment, sonoluminescence (SL) recordings were performed to characterize the spatial distribution of inertial cavitation adjacent to the focal region. High-speed photographs and thermal coagulations, comparing with the SL results, were also recorded and presented. A series of pulse parameters (pulse duration (PD) was between 1 and 23 cycles and pulse repetition frequency (PRF) was between 0.5kHz and 100kHz) were performed to make a systematic investigation under certain acoustic power (APW). Continuous HIFU (cHIFU) investigation was also performed to serve as control group. It was found that, when APW was 19.5W, pHIFU with short PD was much easier to form SL adjacent to the focal region inside the phantom, while it was difficult for cHIFU to generate cavitation bubbles. With appropriate PD and PRF, the residual bubbles of the previous pulses could be stimulated by the incident pulses to oscillate in a higher level and even violently collapse, resulting to enhanced physical thermogenesis. The experimental results showed that the most violent inertial cavitation occurs when PD was set to 6 cycles (5μs) and PRF to 10kHz, while the highest level of thermal coagulation was observed when PD was set to 10 cycles. The cavitational and thermal characteristics were in good correspondence, exhibiting significant potentiality regarding to inject-free cavitation bubble enhanced thermal ablation under lower APW, compared to the conventional thermotherapy. PMID:27150756

  6. Sonoluminescence characterization of inertial cavitation inside a BSA phantom treated by pulsed HIFU.

    PubMed

    Yin, Hui; Chang, Nan; Xu, Shanshan; Wan, Mingxi

    2016-09-01

    The aim of this study was to investigate the inertial cavitation inside a phantom treated by pulsed HIFU (pHIFU). Basic bovine serum albumin (BSA) phantoms without any inherent ultrasound contrast agents (UCAs) or phase-shift nano-emulsions (PSNEs) were used. During the treatment, sonoluminescence (SL) recordings were performed to characterize the spatial distribution of inertial cavitation adjacent to the focal region. High-speed photographs and thermal coagulations, comparing with the SL results, were also recorded and presented. A series of pulse parameters (pulse duration (PD) was between 1 and 23 cycles and pulse repetition frequency (PRF) was between 0.5kHz and 100kHz) were performed to make a systematic investigation under certain acoustic power (APW). Continuous HIFU (cHIFU) investigation was also performed to serve as control group. It was found that, when APW was 19.5W, pHIFU with short PD was much easier to form SL adjacent to the focal region inside the phantom, while it was difficult for cHIFU to generate cavitation bubbles. With appropriate PD and PRF, the residual bubbles of the previous pulses could be stimulated by the incident pulses to oscillate in a higher level and even violently collapse, resulting to enhanced physical thermogenesis. The experimental results showed that the most violent inertial cavitation occurs when PD was set to 6 cycles (5μs) and PRF to 10kHz, while the highest level of thermal coagulation was observed when PD was set to 10 cycles. The cavitational and thermal characteristics were in good correspondence, exhibiting significant potentiality regarding to inject-free cavitation bubble enhanced thermal ablation under lower APW, compared to the conventional thermotherapy.

  7. Characterization of HIFU transducers designed for sonochemistry application: Acoustic streaming.

    PubMed

    Hallez, L; Touyeras, F; Hihn, J-Y; Bailly, Y

    2016-03-01

    Cavitation distribution in a High Intensity Focused Ultrasound sonoreactors (HIFU) has been extensively described in the recent literature, including quantification by an optical method (Sonochemiluminescence SCL). The present paper provides complementary measurements through the study of acoustic streaming generated by the same kind of HIFU transducers. To this end, results of mass transfer measurements (electrodiffusional method) were compared to optical method ones (Particle Image Velocimetry). This last one was used in various configurations: with or without an electrode in the acoustic field in order to have the same perturbation of the wave propagation. Results show that the maximum velocity is not located at the focal but shifted near the transducer, and that this shift is greater for high powers. The two cavitation modes (stationary and moving bubbles) are greatly affect the hydrodynamic behavior of our sonoreactors: acoustic streaming and the fluid generated by bubble motion. The results obtained by electrochemical measurements show the same low hydrodynamic activity in the transducer vicinity, the same shift of the active focal toward the transducer, and the same absence of activity in the post-focal axial zone. The comparison with theoretical Eckart's velocities (acoustic streaming in non-cavitating media) confirms a very high activity at the "sonochemical focal", accounted for by wave distortion, which induced greater absorption coefficients. Moreover, the equivalent liquid velocities are one order of magnitude larger than the ones measured by PIV, confirming the enhancement of mass transfer by bubbles oscillation and collapse close to the surface, rather than from a pure streaming effect.

  8. Influence of ultrasound power on acoustic streaming and micro-bubbles formations in a low frequency sono-reactor: mathematical and 3D computational simulation.

    PubMed

    Sajjadi, Baharak; Raman, Abdul Aziz Abdul; Ibrahim, Shaliza

    2015-05-01

    This paper aims at investigating the influence of ultrasound power amplitude on liquid behaviour in a low-frequency (24 kHz) sono-reactor. Three types of analysis were employed: (i) mechanical analysis of micro-bubbles formation and their activities/characteristics using mathematical modelling. (ii) Numerical analysis of acoustic streaming, fluid flow pattern, volume fraction of micro-bubbles and turbulence using 3D CFD simulation. (iii) Practical analysis of fluid flow pattern and acoustic streaming under ultrasound irradiation using Particle Image Velocimetry (PIV). In mathematical modelling, a lone micro bubble generated under power ultrasound irradiation was mechanistically analysed. Its characteristics were illustrated as a function of bubble radius, internal temperature and pressure (hot spot conditions) and oscillation (pulsation) velocity. The results showed that ultrasound power significantly affected the conditions of hotspots and bubbles oscillation velocity. From the CFD results, it was observed that the total volume of the micro-bubbles increased by about 4.95% with each 100 W-increase in power amplitude. Furthermore, velocity of acoustic streaming increased from 29 to 119 cm/s as power increased, which was in good agreement with the PIV analysis.

  9. Acoustic Cavitation Enhances Focused Ultrasound Ablation with Phase-Shift Inorganic Perfluorohexane Nanoemulsions: An In Vitro Study Using a Clinical Device.

    PubMed

    Zhao, Lu-Yan; Zou, Jian-Zhong; Chen, Zong-Gui; Liu, Shan; Jiao, Jiao; Wu, Feng

    2016-01-01

    Purpose. To investigate whether acoustic cavitation could increase the evaporation of a phase-shift inorganic perfluorohexane (PFH) nanoemulsion and enhance high intensity focused ultrasound (HIFU) ablation. Materials and Methods. PFH was encapsulated by mesoporous silica nanocapsule (MSNC) to form a nanometer-sized droplet (MSNC-PFH). It was added to a tissue-mimicking phantom, whereas phosphate buffered saline (PBS) was added as a control (PBS-control). HIFU (P ac = 150 W, t = 5/10 s) exposures were performed in both phantoms with various duty cycles (DC). US images, temperature, and cavitation emissions were recorded during HIFU exposure. HIFU-induced lesions were measured and calculated. Results. Compared to PBS-control, MSNC-PFH nanoemulsion could significantly increase the volume of HIFU-induced lesion (P < 0.01). Peak temperatures were 78.16 ± 5.64°C at a DC of 100%, 70.17 ± 6.43°C at 10%, 53.17 ± 4.54°C at 5%, and 42.00 ± 5.55°C at 2%, respectively. Inertial cavitation was much stronger in the pulsed-HIFU than that in the continuous-wave HIFU exposure. Compared to 100%-DC exposure, the mean volume of lesion induced by 5 s exposure at 10%-DC was significantly larger, but smaller at 2%-DC. Conclusions. MSNC-PFH nanoemulsion can significantly enhance HIFU ablation. Appropriate pulsed-HIFU exposure could significantly increase the volume of lesion and reduce total US energy required for HIFU ablation. PMID:27419138

  10. Acoustic Cavitation Enhances Focused Ultrasound Ablation with Phase-Shift Inorganic Perfluorohexane Nanoemulsions: An In Vitro Study Using a Clinical Device

    PubMed Central

    Zhao, Lu-Yan; Zou, Jian-Zhong; Chen, Zong-Gui; Liu, Shan; Jiao, Jiao; Wu, Feng

    2016-01-01

    Purpose. To investigate whether acoustic cavitation could increase the evaporation of a phase-shift inorganic perfluorohexane (PFH) nanoemulsion and enhance high intensity focused ultrasound (HIFU) ablation. Materials and Methods. PFH was encapsulated by mesoporous silica nanocapsule (MSNC) to form a nanometer-sized droplet (MSNC-PFH). It was added to a tissue-mimicking phantom, whereas phosphate buffered saline (PBS) was added as a control (PBS-control). HIFU (Pac = 150 W, t = 5/10 s) exposures were performed in both phantoms with various duty cycles (DC). US images, temperature, and cavitation emissions were recorded during HIFU exposure. HIFU-induced lesions were measured and calculated. Results. Compared to PBS-control, MSNC-PFH nanoemulsion could significantly increase the volume of HIFU-induced lesion (P < 0.01). Peak temperatures were 78.16 ± 5.64°C at a DC of 100%, 70.17 ± 6.43°C at 10%, 53.17 ± 4.54°C at 5%, and 42.00 ± 5.55°C at 2%, respectively. Inertial cavitation was much stronger in the pulsed-HIFU than that in the continuous-wave HIFU exposure. Compared to 100%-DC exposure, the mean volume of lesion induced by 5 s exposure at 10%-DC was significantly larger, but smaller at 2%-DC. Conclusions. MSNC-PFH nanoemulsion can significantly enhance HIFU ablation. Appropriate pulsed-HIFU exposure could significantly increase the volume of lesion and reduce total US energy required for HIFU ablation. PMID:27419138

  11. Current Status in Cavitation Modeling

    NASA Technical Reports Server (NTRS)

    Singhal, Ashok K.; Avva, Ram K.

    1993-01-01

    Cavitation is a common problem for many engineering devices in which the main working fluid is in liquid state. In turbomachinery applications, cavitation generally occurs on the inlet side of pumps. The deleterious effects of cavitation include: lowered performance, load asymmetry, erosion and pitting of blade surfaces, vibration and noise, and reduction of the overall machine life. Cavitation models in use today range from rather crude approximations to sophisticated bubble dynamics models. Details about bubble inception, growth and collapse are relevant to the prediction of blade erosion, but are not necessary to predict the performance of pumps. An engineering model of cavitation is proposed to predict the extent of cavitation and performance. The vapor volume fraction is used as an indicator variable to quantify cavitation. A two-phase flow approach is employed with the assumption of the thermal equilibrium between liquid and vapor. At present velocity slip between the two phases is selected. Preliminary analyses of 2D flows shows qualitatively correct results.

  12. Current status in cavitation modeling

    NASA Astrophysics Data System (ADS)

    Singhal, Ashok K.; Avva, Ram K.

    1993-07-01

    Cavitation is a common problem for many engineering devices in which the main working fluid is in liquid state. In turbomachinery applications, cavitation generally occurs on the inlet side of pumps. The deleterious effects of cavitation include: lowered performance, load asymmetry, erosion and pitting of blade surfaces, vibration and noise, and reduction of the overall machine life. Cavitation models in use today range from rather crude approximations to sophisticated bubble dynamics models. Details about bubble inception, growth and collapse are relevant to the prediction of blade erosion, but are not necessary to predict the performance of pumps. An engineering model of cavitation is proposed to predict the extent of cavitation and performance. The vapor volume fraction is used as an indicator variable to quantify cavitation. A two-phase flow approach is employed with the assumption of the thermal equilibrium between liquid and vapor. At present velocity slip between the two phases is selected. Preliminary analyses of 2D flows shows qualitatively correct results.

  13. Ultrasonic cavitation for disruption of microalgae.

    PubMed

    Greenly, Justin M; Tester, Jefferson W

    2015-05-01

    Challenges with mid-stream fractionation steps in proposed microalgae biofuel pathways arise from the typically dilute cell density in growth media, micron scale cell sizes, and often durable cell walls. For microalgae to be a sustainable source of biofuels and co-products, efficient fractionation by some method will be necessary. This study evaluates ultrasonic cell disruption as a processing step that fractionates microalgae. A range of species types with different sizes and cell wall compositions were treated. The initial seconds of sonication offered the most significant disruption, even for the more durable Nannochloropsis cells. Following this initial period, diminishing effectiveness was attributed, by acoustic measurements, to attenuation of the ultrasound in the ensuing cloud of cavitating bubbles. At longer exposure times, differences between species were more pronounced. Processing higher concentrations of Isochrysis slowed cell disintegration only marginally, making the expenditure of energy more worthwhile.

  14. A model of bubble growth leading to xylem conduit embolism.

    PubMed

    Hölttä, T; Vesala, T; Nikinmaa, E

    2007-11-01

    The dynamics of a gas bubble inside a water conduit after a cavitation event was modeled. A distinction was made between a typical angiosperm conduit with a homogeneous pit membrane and a typical gymnosperm conduit with a torus-margo pit membrane structure. For conduits with torus-margo type pits pit membrane deflection was also modeled and pit aspiration, the displacement of the pit membrane to the low pressure side of the pit chamber, was found to be possible while the emboli was still small. Concurrent with pit aspiration, the high resistance to water flow out of the conduit through the cell walls or aspirated pits will make the embolism process slow. In case of no pit aspiration and always for conduits with homogeneous pit membranes, embolism growth is more rapid but still much slower than bubble growth in bulk water under similar water tension. The time needed for the embolism to fill a whole conduit was found to be dependent on pit and cell wall conductance, conduit radius, xylem water tension, pressure rise in adjacent conduits due to water freed from the embolising conduit, and the rigidity and structure of the pits in the case of margo-torus type pit membrane. The water pressure in the conduit hosting the bubble was found to occur almost immediately after bubble induction inside a conduit, creating a sudden tension release in the conduit, which can be detected by acoustic and ultra-acoustic monitoring of xylem cavitation.

  15. Ultrasonic atomization of liquids in drop-chain acoustic fountains

    PubMed Central

    Simon, Julianna C.; Sapozhnikov, Oleg A.; Khokhlova, Vera A.; Crum, Lawrence A.; Bailey, Michael R.

    2015-01-01

    When focused ultrasound waves of moderate intensity in liquid encounter an air interface, a chain of drops emerges from the liquid surface to form what is known as a drop-chain fountain. Atomization, or the emission of micro-droplets, occurs when the acoustic intensity exceeds a liquid-dependent threshold. While the cavitation-wave hypothesis, which states that atomization arises from a combination of capillary-wave instabilities and cavitation bubble oscillations, is currently the most accepted theory of atomization, more data on the roles of cavitation, capillary waves, and even heat deposition or boiling would be valuable. In this paper, we experimentally test whether bubbles are a significant mechanism of atomization in drop-chain fountains. High-speed photography was used to observe the formation and atomization of drop-chain fountains composed of water and other liquids. For a range of ultrasonic frequencies and liquid sound speeds, it was found that the drop diameters approximately equalled the ultrasonic wavelengths. When water was exchanged for other liquids, it was observed that the atomization threshold increased with shear viscosity. Upon heating water, it was found that the time to commence atomization decreased with increasing temperature. Finally, water was atomized in an overpressure chamber where it was found that atomization was significantly diminished when the static pressure was increased. These results indicate that bubbles, generated by either acoustic cavitation or boiling, contribute significantly to atomization in the drop-chain fountain. PMID:25977591

  16. A dynamic pressure view cell for acoustic stimulation of fluids—Micro-bubble generation and fluid movement in porous media

    NASA Astrophysics Data System (ADS)

    Stewart, Robert A.; Shaw, J. M.

    2015-09-01

    The development and baseline operation of an acoustic view cell for observing fluids, and fluid-fluid and fluid-solid interfaces in porous media over the frequency range of 10-5000 Hz is described. This range includes the industrially relevant frequency range 500-5000 Hz that is not covered by existing devices. Pressure waveforms of arbitrary shape are generated in a 17.46 mm ID by 200 mm and 690.5 mm long glass tubes at flow rates up to 200 ml/min using a syringe pump. Peak-to-peak amplitudes exceeding 80 kPa are readily realized at frequencies from 10 to 5000 Hz in bubble free fluids when actuated with 20 Vpp as exemplified using castor oil. At resonant frequencies, peak-to-peak pressure amplitudes exceeding 500 kPa were obtained (castor oil at 2100 Hz when actuated with 20 Vpp). Impacts of vibration on macroscopic liquid-liquid and liquid-vapour interfaces and interface movement are illustrated. Pressure wave transmission and attenuation in a fluid saturated porous medium, randomly packed 250-330 μm spherical silica beads, is also demonstrated. Attenuation differences and frequency shifts in resonant peaks are used to detect the presence and generation of dispersed micro-bubbles (<180 μm diameter), and bubbles within porous media that are not readily visualized. Envisioned applications include assessment of the impacts of vibration on reaction, mass transfer, and flow/flow pattern outcomes. This knowledge will inform laboratory and pilot scale process studies, where nuisance vibrations may affect the interpretation of process outcomes, and large scale or in situ processes in aquifers or hydrocarbon reservoirs where imposed vibration may be deployed to improve aspects of process performance. Future work will include miscible interface observation and quantitative measurements in the bulk and in porous media where the roles of micro-bubbles comprise subjects of special interest.

  17. A dynamic pressure view cell for acoustic stimulation of fluids--Micro-bubble generation and fluid movement in porous media.

    PubMed

    Stewart, Robert A; Shaw, J M

    2015-09-01

    The development and baseline operation of an acoustic view cell for observing fluids, and fluid-fluid and fluid-solid interfaces in porous media over the frequency range of 10-5000 Hz is described. This range includes the industrially relevant frequency range 500-5000 Hz that is not covered by existing devices. Pressure waveforms of arbitrary shape are generated in a 17.46 mm ID by 200 mm and 690.5 mm long glass tubes at flow rates up to 200 ml/min using a syringe pump. Peak-to-peak amplitudes exceeding 80 kPa are readily realized at frequencies from 10 to 5000 Hz in bubble free fluids when actuated with 20 Vpp as exemplified using castor oil. At resonant frequencies, peak-to-peak pressure amplitudes exceeding 500 kPa were obtained (castor oil at 2100 Hz when actuated with 20 Vpp). Impacts of vibration on macroscopic liquid-liquid and liquid-vapour interfaces and interface movement are illustrated. Pressure wave transmission and attenuation in a fluid saturated porous medium, randomly packed 250-330 μm spherical silica beads, is also demonstrated. Attenuation differences and frequency shifts in resonant peaks are used to detect the presence and generation of dispersed micro-bubbles (<180 μm diameter), and bubbles within porous media that are not readily visualized. Envisioned applications include assessment of the impacts of vibration on reaction, mass transfer, and flow/flow pattern outcomes. This knowledge will inform laboratory and pilot scale process studies, where nuisance vibrations may affect the interpretation of process outcomes, and large scale or in situ processes in aquifers or hydrocarbon reservoirs where imposed vibration may be deployed to improve aspects of process performance. Future work will include miscible interface observation and quantitative measurements in the bulk and in porous media where the roles of micro-bubbles comprise subjects of special interest.

  18. Direct visualization of microalgae rupture by ultrasound-driven bubbles

    NASA Astrophysics Data System (ADS)

    Pommella, Angelo; Harun, Irina; Pouliopoulos, Antonis; Choi, James J.; Hellgardt, Klaus; Garbin, Valeria

    2015-11-01

    Cell rupture induced by ultrasound is central to applications in biotechnology. For instance, cell disruption is required in the production of biofuels from microalgae (unicellular species of algae). Ultrasound-induced cavitation, bubble collapse and jetting are exploited to induce sufficiently large viscous stresses to cause rupture of the cell membranes. It has recently been shown that seeding the flow with bubbles that act as cavitation nuclei significantly reduces the energy cost for cell processing. However, a fundamental understanding of the conditions for rupture of microalgae in the complex flow fields generated by ultrasound-driven bubbles is currently lacking. We perform high-speed video microscopy to visualize the miscroscale details of the interaction of Chlamydomonas reinhardtii , microalgae of about 10 μm in size, with ultrasound-driven microbubbles of 2-200 μm in diameter. We investigate the efficiency of cell rupture depending on ultrasound frequency and pressure amplitude (from 10 kPa up to 1 MPa), and the resulting bubble dynamics regimes. In particular we compare the efficiency of membrane rupture in the acoustic microstreaming flow induced by linear oscillations, with the case of violent bubble collapse and jetting. V.G. acknowledges partial support from the European Commission (FP7-PEOPLE-2013-CIG), Grant No. 618333.

  19. Can diving-induced tissue nitrogen supersaturation increase the chance of acoustically driven bubble growth in marine mammals?

    PubMed

    Houser, D S; Howard, R; Ridgway, S

    2001-11-21

    The potential for acoustically mediated causes of stranding in cetaceans (whales and dolphins) is of increasing concern given recent stranding events associated with anthropogenic acoustic activity. We examine a potentially debilitating non-auditory mechanism called rectified diffusion. Rectified diffusion causes gas bubble growth, which in an insonified animal may produce emboli, tissue separation and high, localized pressure in nervous tissue. Using the results of a dolphin dive study and a model of rectified diffusion for low-frequency exposure, we demonstrate that the diving behavior of cetaceans prior to an intense acoustic exposure may increase the chance of rectified diffusion. Specifically, deep diving and slow ascent/descent speed contributes to increased gas-tissue saturation, a condition that amplifies the likelihood of rectified diffusion. The depth of lung collapse limits nitrogen uptake per dive and the surface interval duration influences the amount of nitrogen washout from tissues between dives. Model results suggest that low-frequency rectified diffusion models need to be advanced, that the diving behavior of marine mammals of concern needs to be investigated to identify at-risk animals, and that more intensive studies of gas dynamics within diving marine mammals should be undertaken.

  20. Can diving-induced tissue nitrogen supersaturation increase the chance of acoustically driven bubble growth in marine mammals?

    PubMed

    Houser, D S; Howard, R; Ridgway, S

    2001-11-21

    The potential for acoustically mediated causes of stranding in cetaceans (whales and dolphins) is of increasing concern given recent stranding events associated with anthropogenic acoustic activity. We examine a potentially debilitating non-auditory mechanism called rectified diffusion. Rectified diffusion causes gas bubble growth, which in an insonified animal may produce emboli, tissue separation and high, localized pressure in nervous tissue. Using the results of a dolphin dive study and a model of rectified diffusion for low-frequency exposure, we demonstrate that the diving behavior of cetaceans prior to an intense acoustic exposure may increase the chance of rectified diffusion. Specifically, deep diving and slow ascent/descent speed contributes to increased gas-tissue saturation, a condition that amplifies the likelihood of rectified diffusion. The depth of lung collapse limits nitrogen uptake per dive and the surface interval duration influences the amount of nitrogen washout from tissues between dives. Model results suggest that low-frequency rectified diffusion models need to be advanced, that the diving behavior of marine mammals of concern needs to be investigated to identify at-risk animals, and that more intensive studies of gas dynamics within diving marine mammals should be undertaken. PMID:11894990

  1. Monitoring Cavitation in HIFU as an Aid to Assisting Treatment

    NASA Astrophysics Data System (ADS)

    Hsieh, Chang-yu; Smith, Penny Probert; Kennedy, James; Leslie, Thomas

    2007-05-01

    Rapid hypothermia resulting in tissue necrosis is often associated with bubble activity (normally from cavitation) in HIFU treatment. Indeed in some HIFU protocols, the evidence of cavitation is taken as an indicator of tissue lesions. In this paper we discuss two methods to delineate reliably the region in which cavitation occurs, so that a history of the cavitation events can be provided automatically during treatment. Results are shown on simulated images and from a clinical treatment session.

  2. Acoustic monitoring of co-seismic changes in gas bubble rupture rate in a hydrothermal reservoir: field evaluation of a possible precursor and mechanism for remote seismic triggering

    NASA Astrophysics Data System (ADS)

    Crews, J. B.

    2015-12-01

    Remotely triggered seismicity is a phenomenon in which an earthquake at one location triggers others over distances up to thousands of kilometers. The mechanism by which low-amplitude dynamic oscillations of the confining stress can produce such an effect, often after a time delay of minutes-to-days, is unclear, but a concentration of remotely triggered seismic events in carbon-dioxide-rich volcanic and geothermal regions suggests that an increase in pore fluid pressure associated with the nucleation and growth of carbon-dioxide gas bubbles may reduce the effective stress in critically loaded geologic faults. While this hypothesis has been tested in bench-scale laboratory experiments, field detection of seismically initiated gas bubble growth in groundwater may provide further evidence for this remote triggering mechanism. In the present study, a hydrophone continuously records the acoustic power spectrum in CH-10B, a hydrothermal well located in Long Valley Caldera, California - a site that is susceptible to remotely seismic triggering. This well exhibits co-seismic changes in water level in response to near and distant earthquakes, including every magnitude-six or greater at any location on Earth. Exploiting the inverse relationship between gas bubble radius and the peak acoustic frequency emitted when a gas bubble ruptures, this investigation seeks to detect changes in the acoustic power spectrum arising from a shift in the size-distribution or count rate of rupturing gas bubbles, coincident with a distant earthquake. By resolving the timing and intensity of the onset of a change in gas bubble rupture rate after the passage of seismic wave from a distant source, it may be possible to establish the extent to which seismically initiated gas bubble growth contributes to co-seismic borehole water level response, pore fluid pressure perturbations, and the onset of remotely triggered seismicity.

  3. Vapor Cavitation in Dynamically Loaded Journal Bearings

    NASA Technical Reports Server (NTRS)

    Jacobson, B. O.; Hamrock, B. J.

    1983-01-01

    High speed motion camera experiments were performed on dynamically loaded journal bearings. The length to diameter ratio of the bearing, the speed of the roller and the tube, the surface material of the roller, and the static and dynamic eccentricity of the bearing were varied. One hundred and thirty-four cases were filmed. The occurrence of vapor cavitation was clearly evident in the films and figures presented. Vapor cavitation was found to occur when the tensile stress applied to the oil exceeded the tensile strength of the oil or the binding of the oil to the surface. The physical situation in which vapor cavitation occurs is during the squeezing and sliding motion within a bearing. Besides being able to accurately capture the vapor cavitation on film, an analysis of the formation and collapse of the cavitation bubbles and characteristics of the bubble content are presented.

  4. Large Volume Coagulation Utilizing Multiple Cavitation Clouds Generated by Array Transducer Driven by 32 Channel Drive Circuits

    NASA Astrophysics Data System (ADS)

    Nakamura, Kotaro; Asai, Ayumu; Sasaki, Hiroshi; Yoshizawa, Shin; Umemura, Shin-ichiro

    2013-07-01

    High-intensity focused ultrasound (HIFU) treatment is a noninvasive treatment, in which focused ultrasound is generated outside the body and coagulates a diseased tissue. The advantage of this method is minimal physical and mental stress to the patient, and the disadvantage is the long treatment time caused by the smallness of the therapeutic volume by a single exposure. To improve the efficiency and shorten the treatment time, we are focusing attention on utilizing cavitation bubbles. The generated microbubbles can convert the acoustic energy into heat with a high efficiency. In this study, using the class D amplifiers, which we have developed, to drive the array transducer, we demonstrate a new method to coagulate a large volume by a single HIFU exposure through generating cavitation bubbles distributing in a large volume and vibrating all of them. As a result, the coagulated volume by the proposed method was 1.71 times as large as that of the conventional method.

  5. CAVITATION DAMAGE STUDY VIA A NOVEL REPETITIVE PRESSURE PULSE APPROACH

    SciTech Connect

    Wang, Jy-An John; Ren, Fei; Wang, Hong

    2010-01-01

    Cavitation damage can significantly affect system performance. Thus, there is great interest in characterizing cavitation damage and improving materials resistance to cavitation damage. In this paper, we present a novel methodology to simulate cavitation environment. A pulsed laser is utilized to induce optical breakdown in the cavitation media, with the emission of shock wave and the generation of bubbles. The pressure waves induced by the optical breakdown fluctuate/propagate within the media, which enables the cavitation to occur and to further develop cavitation damage at the solid boundary. Using the repetitive pulsed-pressure apparatus developed in the current study, cavitation damage in water media was verified on stainless steel and aluminum samples. Characteristic cavitation damages such as pitting and indentation are observed on sample surfaces using scanning electron microscopy.

  6. Continuous Cavitation Designed for Enhancing Radiofrequency Ablation via a Special Radiofrequency Solidoid Vaporization Process.

    PubMed

    Zhang, Kun; Li, Pei; Chen, Hangrong; Bo, Xiaowan; Li, Xiaolong; Xu, Huixiong

    2016-02-23

    Lowering power output and radiation time during radiofrequency (RF) ablation is still a challenge. Although it is documented that metal-based magnetothermal conversion and microbubbles-based inertial cavitation have been tried to overcome above issues, disputed toxicity and poor magnetothermal conversion efficiency for metal-based nanoparticles and violent but transient cavitation for microbubbles are inappropriate for enhancing RF ablation. In this report, a strategy, i.e., continuous cavitation, has been proposed, and solid menthol-encapsulated poly lactide-glycolide acid (PLGA) nanocapsules have been constructed, as a proof of concept, to validate the role of such a continuous cavitation principle in continuously enhancing RF ablation. The synthesized PLGA-based nanocapsules can respond to RF to generate menthol bubbles via distinctive radiofrequency solidoid vaporization (RSV) process, meanwhile significantly enhance ultrasound imaging for HeLa solid tumor, and further facilitate RF ablation via the continuous cavitation, as systematically demonstrated both in vitro and in vivo. Importantly, this RSV strategy can overcome drawbacks and limitations of acoustic droplet vaporization (ADV) and optical droplet vaporization (ODV), and will probably find broad applications in further cancer theranostics. PMID:26800221

  7. Acoustic wave propagation in air-bubble curtains in water. Part 2. Field experiment

    SciTech Connect

    Domenico, S.N.

    1982-03-01

    A field experiment consisted of hydrophone recordings in a pond, 25 ft deep, of signals transmitted through air-bubble curtains from a water gun source. The air curtains issued from one to 13 pipes (20 ft long and spaced at 1.67-ft intervals). Air pressures used in the pipes were 15, 25, and 50 psi. Length and complexity of the signals indicate that reverberations occurred to an increasing extent as the number of consecutive air curtains was increased. Analysis of the first pulse in the recorded signals, after approximate removal of hydrophone and recorder response, indicates that the reverberations occur principally in the bubble-free corridors between air curtains. This pulse broadens and its peak amplitude is delayed linearly as the number of successive air curtains is increased. The peak amplitude is decreased substantially by the first air curtain and thereafter remains between 0.1 and 0.2 of the amplitude without air curtains.

  8. Feedback loop process for controlling inertial cavitation: experimental evidence

    NASA Astrophysics Data System (ADS)

    Inserra, Claude; Sabraoui, Abbas; Reslan, Lina; Bera, Jean-Christophe; Gilles, Bruno; Mestas, Jean-Louis

    2011-09-01

    Applications involving cavitation mechanisms, such as sonoporation, are irreproducible in the case of a fixed-intensity sonication, due to the non-stationary behavior of cavitation. We then propose to work at a fixed-cavitation level instead of under fixed-intensity sonication conditions. For this purpose a regulated cavitation generator has been developed in a stationary wave field configuration, which allows regulation of the cavitation level during sonication by modulating the applied acoustic intensity with a feedback loop based on acoustic cavitation measurements. The cavitation level indicator was quantified by the broadband spectrum noise level relative to inertial cavitation events. This generated inertial cavitation was characterized by both acoustic and chemical measurements, quantifying hydroxyl radicals produced by water sonolysis. While the cavitation level is obtained with a 40% standard deviation for fixed applied acoustic intensities in the range [0.01 3.44] W/cm2, the regulated generator reproduces the cavitation level with a standard deviation of 3%. The results show that the hydroxyl radical production is better correlated with the cavitation level setting than with the applied acoustic intensity, highlighting the fact that broadband noise is a good indicator of inertial cavitation, with greatest interest for cavitation monitoring. In summary, the regulated device generates a cavitation level that is reproducible, repeatable and stable in time. This system produces reproducible effects that allow consideration of biological applications such as sonoporation to be independent of the experimental ultrasound device, as confirmed by transfection efficiency and cell cytotoxicity studies. Thus, this feedback loop process presents interesting perspectives for monitoring and controlling in-vivo cavitation.

  9. Cavitation and Fusion

    NASA Astrophysics Data System (ADS)

    Stringham, Roger S.

    2005-12-01

    Natural cavitation phenomena in D2O using piezo devices, is now amplified initiating DD fusion events that produce heat and helium. The transient cavitation bubble produces micro accelerators in the form of jets containing high densities of deuterons, 1024-25/cc from the cavitating D2O. An electrically driven piezo device in a reactor filled with D2O produces jets that implant deuterons into a target foil producing 4He and T plus heat. There is no long range radiation associated with this process. We are moving in the direction of utilizing smaller systems by gaining faster and less expensive technology growth moving from successes at 0.2 and 0.4 MHz to 1.7 MHz. One of the results of our low frequency studies is a 1 to 3 MHz induced standing wave in our target foils. We are using sonoluminescence intensity as a tool to guide us in finding highest plasma density in the adiabatic bubble collapse process in the jet plasma formation. The generation of these sonoluminescence photons relates to conditions for the target implantation process. These experiments and the analytical methods have concentrated on the mass spectroscopy of reactor gases, calorimetry of the reactor and power supply, and the scanning electron microscope photographs of target foils. This work provides a path for an ecological and hydrocarbon-free energy source for all energy applications.

  10. Application of signal analysis to cavitation

    NASA Technical Reports Server (NTRS)

    Martin, C. S.; Veerabhadra Rao, P.

    1984-01-01

    The diagnostic facilities of the cross power spectrum and the coherence function have been employed to enhance the identification of not only the inception of cavitation, but also its level. Two piezoelectric pressure transducers placed in the downstream chamber of a model spool valve undergoing various levels of cavitation allowed for the use of both functions - the phase angle of the complex cross spectrum and the dimensionless coherence function - to sense clearly the difference between noise levels associated with a noncavitating jet from those once cavitation inception is attained. The cavitation noise within the chamber exhibited quite a regular character in terms of the phase difference between instruments for limited cavitation. Varying cavitation levels clearly illustrated the effect of bubble size on the attendant frequency range for which there was an extremely high coherence or nearly perfect causality.

  11. A numerical model for the evolution of internal structure of cavitation cloud

    NASA Astrophysics Data System (ADS)

    Du, Tezhuan; Wang, Yiwei; Liao, Lijuan; Huang, Chenguang

    2016-07-01

    Bubble size distributions in cloud cavitation are important in cavitating flows. In this study, a numerical model was developed to study the evolution of the internal structure of cloud cavitation. The model includes (1) an evolution equation of bubble number density, which considers the bubble breakup effect and (2) the multiphase Reynolds-averaged Navier-Stokes equations with a modified cavitation model for background cavitating flows. The proposed model was validated with a flow over a projectile. Results show that the numerical model can predict the evolution of the internal structure of cloud cavitation. Comparisons of the proposed model and Singhal model were discussed. The effects of re-entrant jet and bubble number density on cavitating flows were also investigated.

  12. Drug-loaded bubbles with matched focused ultrasound excitation for concurrent blood-brain barrier opening and brain-tumor drug delivery.

    PubMed

    Fan, Ching-Hsiang; Ting, Chien-Yu; Chang, Yuan-Chih; Wei, Kuo-Chen; Liu, Hao-Li; Yeh, Chih-Kuang

    2015-03-01

    Focused ultrasound (FUS) with microbubbles has been used to achieve local blood-brain barrier opening (BBB opening) and increase the penetration of therapeutic drugs into brain tumors. However, inertial cavitation of microbubbles during FUS-induced BBB opening causes intracerebral hemorrhaging (ICH), leading to acute and chronic brain injury and limiting the efficiency of drug delivery. Here we investigated whether induction of drug (1,3-bis(2-chloroethyl)-1-nitrosourea, BCNU)-loaded bubbles (BCNU bubbles) to oscillate at their resonant frequency would reduce inertial cavitation during BBB opening, thereby eliminating ICH and enhancing drug delivery in a rat brain model. FUS was tested at 1 and 10 MHz, over a wide range of pressure (mechanical index ranging from 0.16 to 1.42) in the presence of BCNU bubbles. Excitation of BCNU bubbles by resonance frequency-matched FUS (10 MHz) resulted in predominantly stable cavitation and significantly reduced the occurrence of potential hazards of exposure to biological tissues during the BBB opening process. In addition, the drug release process could be monitored by acoustic emission obtained from ultrasound imaging. In tumor-bearing animals, BCNU bubbles with FUS showed significant control of tumor progression and improved maximum survival from 26 to 35 days. This study provides useful advancements toward the goal of successfully translating FUS theranostic bubble-enhanced brain drug delivery into clinical use.

  13. Bubble diagnostics

    DOEpatents

    Visuri, Steven R.; Mammini, Beth M.; Da Silva, Luiz B.; Celliers, Peter M.

    2003-01-01

    The present invention is intended as a means of diagnosing the presence of a gas bubble and incorporating the information into a feedback system for opto-acoustic thrombolysis. In opto-acoustic thrombolysis, pulsed laser radiation at ultrasonic frequencies is delivered intraluminally down an optical fiber and directed toward a thrombus or otherwise occluded vessel. Dissolution of the occlusion is therefore mediated through ultrasonic action of propagating pressure or shock waves. A vapor bubble in the fluid surrounding the occlusion may form as a result of laser irradiation. This vapor bubble may be used to directly disrupt the occlusion or as a means of producing a pressure wave. It is desirable to detect the formation and follow the lifetime of the vapor bubble. Knowledge of the bubble formation and lifetime yields critical information as to the maximum size of the bubble, density of the absorbed radiation, and properties of the absorbing material. This information can then be used in a feedback system to alter the irradiation conditions.

  14. Cavitating Langmuir turbulence in the terrestrial aurora.

    PubMed

    Isham, B; Rietveld, M T; Guio, P; Forme, F R E; Grydeland, T; Mjølhus, E

    2012-03-01

    Langmuir cavitons have been artificially produced in Earth's ionosphere, but evidence of naturally occurring cavitation has been elusive. By measuring and modeling the spectra of electrostatic plasma modes, we show that natural cavitating, or strong, Langmuir turbulence does occur in the ionosphere, via a process in which a beam of auroral electrons drives Langmuir waves, which in turn produce cascading Langmuir and ion-acoustic excitations and cavitating Langmuir turbulence. The data presented here are the first direct evidence of cavitating Langmuir turbulence occurring naturally in any space or astrophysical plasma. PMID:22463417

  15. Acoustic radiation force on an air bubble and soft fluid spheres in ideal liquids: Example of a high-order Bessel beam of quasi-standing waves

    NASA Astrophysics Data System (ADS)

    Mitri, F. G.

    2009-04-01

    The partial wave series for the scattering of a high-order Bessel beam (HOBB) of acoustic quasi-standing waves by an air bubble and fluid spheres immersed in water and centered on the axis of the beam is applied to the calculation of the acoustic radiation force. A HOBB refers to a type of beam having an axial amplitude null and an azimuthal phase gradient. Radiation force examples obtained through numerical evaluation of the radiation force function are computed for an air bubble, a hexane, a red blood and mercury fluid spheres in water. The examples were selected to illustrate conditions having progressive, standing and quasi-standing waves with appropriate selection of the waves’ amplitude ratio. An especially noteworthy result is the lack of a specific vibrational mode contribution to the radiation force determined by appropriate selection of the HOBB parameters.

  16. Experimental and Theoretical Investigations of Cavitation in Water

    NASA Technical Reports Server (NTRS)

    Ackeret, J.

    1945-01-01

    The cavitation in nozzles on airfoils of various shape and on a sphere are experimentally investigated. The limits of cavitation and the extension of the zone of the bubbles in different stages of cavitation are photographically established. The pressure in the bubble area is constant and very low, jumping to high values at the end of the area. The analogy with the gas compression shock is adduced and discussed. The collapse of the bubbles under compression shock produces very high pressures internally, which must be contributory factors to corrosion. The pressure required for purely mechanical corrosion is also discussed.

  17. Experimental investigation of cavitation in pump inlet

    NASA Astrophysics Data System (ADS)

    Sikora, Roman; Bureček, Adam; Hružík, Lumír; Vašina, Martin

    2015-05-01

    The article deals with experimental research of cavitation development in inlet tube of hydraulic pump. The pressures in inlet and outlet tube of the pump and flow rate were measured. Mineral oil was used as working fluid. The cavitation was visually evaluated in transparent inlet tube. The inlet tube underpressure was achieved by throttle valve. The relationship between the generation of bubbles and the inlet pressure is evaluated.

  18. Deformation of biological cells in the acoustic field of an oscillating bubble

    PubMed Central

    Zinin, Pavel V.; Allen, John S.

    2009-01-01

    In this work we develop a theoretical framework of the interaction of microbubbles with bacteria in the ultrasound field using a shell model of the bacteria, following an approach developed previously [P. V. Zinin et al., Phys. Rev. E 72, 61907 (2005)]. Within the shell model, the motion of the cell in an ultrasonic field is determined by the motion of three components: the internal viscous fluid, a thin elastic shell, and the surrounding viscous fluid. Several conclusions can be drawn from the modeling of sound interaction with a biological cell: (a) the characteristics of a cell’s oscillations in an ultrasonic field are determined both by the elastic properties of the shell the viscosities of all components of the system, (b) for dipole quadrupole oscillations the cell’s shell deforms due to a change in the shell area this oscillation depends on the surface area modulus KA, (c) the relative change in the area has a maximum at frequency fK∼12πKA/(ρa3), where a is the cell’s radius and ρ is its density. It was predicted that deformation of the cell wall at the frequency fK is high enough to rupture small bacteria such as E. coli in which the quality factor of natural vibrations is less than 1 (Q < 1). For bacteria with high value quality factors (Q > 1), the area deformation has a strong peak near a resonance frequency fK; however, the value of the deformation near the resonance frequency is not high enough to produce sufficient mechanical effect. The theoretical framework developed in this work can be extended for describing the deformation of a biological cell under any arbitrary, external periodic force including radiation forces unduced by acoustical (acoustical levitation) or optical waves (optical tweezers). PMID:19391781

  19. Deformation of biological cells in the acoustic field of an oscillating bubble.

    PubMed

    Zinin, Pavel V; Allen, John S

    2009-02-01

    In this work we develop a theoretical framework of the interaction of microbubbles with bacteria in the ultrasound field using a shell model of the bacteria, following an approach developed previously [P. V. Zinin, Phys. Rev. E 72, 61907 (2005)]. Within the shell model, the motion of the cell in an ultrasonic field is determined by the motion of three components: the internal viscous fluid, a thin elastic shell, and the surrounding viscous fluid. Several conclusions can be drawn from the modeling of sound interaction with a biological cell: (a) the characteristics of a cell's oscillations in an ultrasonic field are determined both by the elastic properties of the shell the viscosities of all components of the system, (b) for dipole quadrupole oscillations the cell's shell deforms due to a change in the shell area this oscillation depends on the surface area modulus K{A} , (c) the relative change in the area has a maximum at frequency f{K} approximately 1/2pi square root[K{A}(rhoa;{3})] , where a is the cell's radius and rho is its density. It was predicted that deformation of the cell wall at the frequency f{K} is high enough to rupture small bacteria such as E . coli in which the quality factor of natural vibrations is less than 1 (Q<1). For bacteria with high value quality factors (Q>1) , the area deformation has a strong peak near a resonance frequency f{K} however, the value of the deformation near the resonance frequency is not high enough to produce sufficient mechanical effect. The theoretical framework developed in this work can be extended for describing the deformation of a biological cell under any arbitrary, external periodic force including radiation forces unduced by acoustical (acoustical levitation) or optical waves (optical tweezers). PMID:19391781

  20. Investigation of bubble-bubble interaction effect during the collapse of multi-bubble system

    NASA Astrophysics Data System (ADS)

    Shao, Xueming; Zhang, Lingxin; Wang, Wenfeng

    2014-11-01

    Bubble collapse is not only an important subject among bubble dynamics, but also a key consequence of cavitation. It has been demonstrated that the structural damage is associated with the rapid change in flow fields during bubble collapse. How to model and simulate the behavior of the bubble collapse is now of great interest. In the present study, both theoretical analysis and a direct numerical simulation on the basis of VOF are performed to investigate the collapses of single bubble and bubble cluster. The effect of bubble-bubble interaction on the collapse of multi-bubble system is presented. The work was supported by the National Natural Science Foundation of China (11272284, 11332009).

  1. Ultrafast active cavitation imaging with enhanced cavitation to tissue ratio based on wavelet transform and pulse inversion.

    PubMed

    Liu, Runna; Hu, Hong; Xu, Shanshan; Huo, Rui; Wang, Supin; Wan, Mingxi

    2015-06-01

    The quality of ultrafast active cavitation imaging (UACI) using plane wave transmission is hindered by low transmission pressure, which is necessary to prevent bubble destruction. In this study, a UACI method that combined wavelet transform with pulse inversion (PI) was proposed to enhance the contrast between the cavitation bubbles and surrounding tissues. The main challenge in using wavelet transform is the selection of the optimum mother wavelet. A mother wavelet named "cavitation bubble wavelet" and constructed according to Rayleigh-Plesset-Noltingk-Neppiras-Poritsky model was expected to obtain a high correlation between the bubbles and beamformed echoes. The method was validated by in vitro experiments. Results showed that the image quality was associated with the initial radius of bubble and the scale. The signal-to-noise ratio (SNR) of the best optimum cavitation bubble wavelet transform (CBWT) mode image was improved by 3.2 dB compared with that of the B-mode image in free-field experiments. The cavitation-to-tissue ratio of the best optimum PI-based CBWT mode image was improved by 2.3 dB compared with that of the PI-based B-mode image in tissue experiments. Furthermore, the SNR versus initial radius curve had the potential to estimate the size distribution of cavitation bubbles.

  2. Enhancement of heat and mass transfer by cavitation

    NASA Astrophysics Data System (ADS)

    Zhang, Y. N.; Zhang, Y. N.; Du, X. Z.; Xian, H. Z.

    2015-01-01

    In this paper, a brief summary of effects of cavitation on the heat and mass transfer are given. The fundamental studies of cavitation bubbles, including its nonlinearity, rectified heat and mass diffusion, are initially introduced. Then selected topics of cavitation enhanced heat and mass transfer were discussed in details including whales stranding caused by active sonar activity, pool boiling heat transfer, oscillating heat pipe and high intensity focused ultrasound treatment.

  3. Simultaneous pressure measurement and high-speed photography study of cavitation in a dynamically loaded journal bearing

    NASA Technical Reports Server (NTRS)

    Sun, D. C.; Brewe, D. E.; Abel, P. B.

    1993-01-01

    Cavitation of the oil film in a dynamically loaded journal bearing was studied using high-speed photography and pressure measurement simultaneously. Comparison of the visual and pressure data provided considerable insight into the occurence and non-occurrence of cavitation. It was found that (1), cavitation typically occurred in the form of one bubble with the pressure in the cavitation bubble close to the absolute zero; and (2), for cavitation-producing operating conditions, cavitation did not always occur; with the oil film then supporting a tensile stress.

  4. Simultaneous pressure measurement and high-speed photography study of cavitation in a dynamically loaded journal bearing

    NASA Technical Reports Server (NTRS)

    Sun, D. C.; Brewe, David E.; Abel, Philip B.

    1994-01-01

    Cavitation of the oil film in a dynamically loaded journal bearing was studied using high-speed photography and pressure measurement simultaneously. Comparison of the visual and pressure data provided considerable insight into the occurrence and nonoccurrence of cavitation. It was found that (1) for the submerged journal bearing, cavitation typically occurred in the form of one bubble with the pressure in the cavitation bubble close to the absolute zero; and (2) for cavitation-producing operating conditions, cavitation did not always occur; with the oil film then supporting a tensile stress.

  5. A Eulerian-Lagrangian description of cavitating flow

    NASA Astrophysics Data System (ADS)

    Iben, U.; Ivanov, N. G.; Isaenko, I. I.; Schmidt, A. A.

    2015-12-01

    We propose a method of cavitating flow calculation that is based on the Eulerian-Lagrangian description of multiphase flows. The formation and growth of cavitation bubbles are described using the model of heterogeneous volume nucleation. Results of test calculations demonstrate the efficiency of the proposed model.

  6. Radiation induced cavitation: A possible phenomenon in liquid targets?

    SciTech Connect

    West, C.D.

    1998-07-01

    The proposed design of a new, short-pulse spallation neutron source includes a liquid mercury target irradiated with a 1 GeV proton beam. This paper explores the possibility that cavitation bubbles may be formed in the mercury and briefly discusses some design features that could avoid harmful effects should cavitation take place.

  7. Numerical investigation of cavitation performance on bulb tubular turbine

    NASA Astrophysics Data System (ADS)

    Sun, L. G.; Guo, P. C.; Zheng, X. B.; Luo, X. Q.

    2016-05-01

    The cavitation flow phenomena may occur in the bulb tubular turbine at some certain operation conditions, which even decrease the performance of units and causes insatiably noise and vibration when it goes worse. A steady cavitating flow numerical simulations study is carried out on the bulb tubular unit with the same blade pitch angle and different guide vane openings by using the commercial code ANSYS CFX in this paper. The phenomena of cavitation induction areas and development process are obtained and draws cavitation performance curves. The numerical results show that the travelling bubble cavity is the main types of cavitation development over a wide operating range of discharge and this type of cavitation begins to sensitive to the value of cavitation number when the discharge exceeding a certain valve, in this condition, it can lead to a severe free bubble formation with the gradually decrement of cavitation number. The reported cavitation performance curves results indicate that the flow blockage incident would happen because of a mount of free bubble formation in the flow passage when the cavity developed to certain extend, which caused head drop behavior and power broken dramatically and influenced the output power.

  8. Cavitation dynamics on the nanoscale

    SciTech Connect

    Kotaidis, Vassilios; Plech, Anton

    2005-11-21

    The ultrafast excitation of gold nanoparticle sols causes a strong nonequilibrium heating of the particle lattice and subsequently of the water shell close to the particle surface. Above a threshold in laser fluence, which is defined by the onset of homogeneous nucleation, nanoscale vapor bubbles develop around the particles, expand and collapse again within the first nanosecond after excitation. We show the existence of cavitation on the nanometer and subnanosecond time scale, described within the framework of continuum thermodynamics.

  9. Stem Hydraulic Conductivity depends on the Pressure at Which It Is Measured and How This Dependence Can Be Used to Assess the Tempo of Bubble Pressurization in Recently Cavitated Vessels.

    PubMed

    Wang, Yujie; Liu, Jinyu; Tyree, Melvin T

    2015-12-01

    Cavitation of water in xylem vessels followed by embolism formation has been authenticated for more than 40 years. Embolism formation involves the gradual buildup of bubble pressure (air) to atmospheric pressure as demanded by Henry's law of equilibrium between gaseous and liquid phases. However, the tempo of pressure increase has not been quantified. In this report, we show that the rate of pressurization of embolized vessels is controlled by both fast and slow kinetics, where both tempos are controlled by diffusion but over different spatial scales. The fast tempo involves a localized diffusion from endogenous sources: over a distance of about 0.05 mm from water-filled wood to the nearest embolized vessels; this process, in theory, should take <2 min. The slow tempo involves diffusion of air from exogenous sources (outside the stem). The latter diffusion process is slower because of the increased distance of diffusion of up to 4 mm. Radial diffusion models and experimental measurements both confirm that the average time constant is >17 h, with complete equilibrium requiring 1 to 2 d. The implications of these timescales for the standard methods of measuring percentage loss of hydraulic conductivity are discussed in theory and deserve more research in future.

  10. Stem Hydraulic Conductivity depends on the Pressure at Which It Is Measured and How This Dependence Can Be Used to Assess the Tempo of Bubble Pressurization in Recently Cavitated Vessels1[OPEN

    PubMed Central

    Liu, Jinyu; Tyree, Melvin T.

    2015-01-01

    Cavitation of water in xylem vessels followed by embolism formation has been authenticated for more than 40 years. Embolism formation involves the gradual buildup of bubble pressure (air) to atmospheric pressure as demanded by Henry’s law of equilibrium between gaseous and liquid phases. However, the tempo of pressure increase has not been quantified. In this report, we show that the rate of pressurization of embolized vessels is controlled by both fast and slow kinetics, where both tempos are controlled by diffusion but over different spatial scales. The fast tempo involves a localized diffusion from endogenous sources: over a distance of about 0.05 mm from water-filled wood to the nearest embolized vessels; this process, in theory, should take <2 min. The slow tempo involves diffusion of air from exogenous sources (outside the stem). The latter diffusion process is slower because of the increased distance of diffusion of up to 4 mm. Radial diffusion models and experimental measurements both confirm that the average time constant is >17 h, with complete equilibrium requiring 1 to 2 d. The implications of these timescales for the standard methods of measuring percentage loss of hydraulic conductivity are discussed in theory and deserve more research in future. PMID:26468516

  11. Unorthodox bubbles when boiling in cold water.

    PubMed

    Parker, Scott; Granick, Steve

    2014-01-01

    High-speed movies are taken when bubbles grow at gold surfaces heated spotwise with a near-infrared laser beam heating water below the boiling point (60-70 °C) with heating powers spanning the range from very low to so high that water fails to rewet the surface after bubbles detach. Roughly half the bubbles are conventional: They grow symmetrically through evaporation until buoyancy lifts them away. Others have unorthodox shapes and appear to contribute disproportionately to heat transfer efficiency: mushroom cloud shapes, violently explosive bubbles, and cavitation events, probably stimulated by a combination of superheating, convection, turbulence, and surface dewetting during the initial bubble growth. Moreover, bubbles often follow one another in complex sequences, often beginning with an unorthodox bubble that stirs the water, followed by several conventional bubbles. This large dataset is analyzed and discussed with emphasis on how explosive phenomena such as cavitation induce discrepancies from classical expectations about boiling.

  12. The effect of static pressure on the strength of inertial cavitation events.

    PubMed

    Bader, Kenneth B; Mobley, Joel; Church, Charles C; Gaitan, D Felipe

    2012-10-01

    Recent investigations of cavitation in fluids pressurized up to 30 MPa found that the intensity of light emissions increased by 1000-fold over that measured for single bubble sonoluminescence. A series of measurements is reported here to extend this original work by resolving the static pressure dependence of the shock wave and light emissions from the first and the most energetic collapses, along with the total shock wave energy and light emissions for the event. Each of these parameters was found to increase with the static pressure of the fluid. Furthermore, the energy of these shock wave and light emissions was found to increase in proportion to the stored acoustic energy in the system. These findings were corroborated using the Gilmore equation to numerically compute the work done by the liquid during the bubble collapse. The overall findings suggest that the increased collapse strength at high static pressure is due to the increased tension required to generate inertial cavitation, and not an increased pressure gradient between the interior of the vaporous bubble and the surrounding liquid.

  13. Investigation of noninertial cavitation produced by an ultrasonic horn.

    PubMed

    Birkin, Peter R; Offin, Douglas G; Vian, Christopher J B; Leighton, Timothy G; Maksimov, Alexey O

    2011-11-01

    This paper reports on noninertial cavitation that occurs beyond the zone close to the horn tip to which the inertial cavitation is confined. The noninertial cavitation is characterized by collating the data from a range of measurements of bubbles trapped on a solid surface in this noninertial zone. Specifically, the electrochemical measurement of mass transfer to an electrode is compared with high-speed video of the bubble oscillation. This gas bubble is shown to be a "noninertial" event by electrochemical surface erosion measurements and "ring-down" experiments showing the activity and motion of the bubble as the sound excitation was terminated. These measurements enable characterization of the complex environment produced below an operating ultrasonic horn outside of the region where inertial collapse can be detected. The extent to which solid boundaries in the liquid cause the frequencies and shapes of oscillatory modes on the bubble wall to differ from their free field values is discussed. PMID:22088002

  14. A numerical study on the effects of cavitation on orifice flow

    NASA Astrophysics Data System (ADS)

    Dabiri, S.; Sirignano, W. A.; Joseph, D. D.

    2010-04-01

    Previous experimental studies have shown better atomization of sprays generated by high-pressure liquid injectors when cavitation occurs inside the nozzle. It has been proposed that the collapse of traveling cavitation bubbles increases the disturbances inside the liquid flow. These disturbances will later trigger the instabilities in the emerged jet and cause a shorter breakup distance. In this paper, effects of cavitation on increasing the disturbances in the flow through the orifice of an atomizer are studied. In previous cavitation models, spherical cavitation bubbles are considered. Here, the cavitation bubbles are allowed to deform as they travel through the orifice. Dynamics of the cavitation bubble, traveling in the separated shear layer in the orifice, is analyzed through a one-way coupling between the orifice flow and bubble dynamics. Effects of shear strain, normal strain, and pressure variation are examined. Three mechanisms are suggested that could be responsible for the increase in disturbances in the flow due to cavitation. These mechanisms are monopole, quadrupole, and vorticities generated during growth and collapse of cavitation bubbles. The effects of these mechanisms are estimated by postprocessing of the solutions to the Navier-Stokes equations to identify monopole and quadrupole behaviors.

  15. Cavitation occurrence around ultrasonic dental scalers.

    PubMed

    Felver, Bernhard; King, David C; Lea, Simon C; Price, Gareth J; Damien Walmsley, A

    2009-06-01

    Ultrasonic scalers are used in dentistry to remove calculus and other contaminants from teeth. One mechanism which may assist in the cleaning is cavitation generated in cooling water around the scaler. The vibratory motion of three designs of scaler tip in a water bath has been characterised by laser vibrometry, and compared with the spatial distribution of cavitation around the scaler tips observed using sonochemiluminescence from a luminol solution. The type of cavitation was confirmed by acoustic emission analysed by a 'Cavimeter' supplied by NPL. A node/antinode vibration pattern was observed, with the maximum displacement of each type of tip occurring at the free end. High levels of cavitation activity occurred in areas surrounding the vibration antinodes, although minimal levels were observed at the free end of the tip. There was also good correlation between vibration amplitude and sonochemiluminescence at other points along the scaler tip. 'Cavimeter' analysis correlated well with luminol observations, suggesting the presence of primarily transient cavitation.

  16. Rayleigh scattering on the cavitation region emerging in liquids.

    PubMed

    Shneider, M N; Pekker, M

    2016-03-15

    It is shown that the scattering of laser radiation off cavitation ruptures in fluids is similar to scattering by gas particles. When the characteristic dimensions of microscopic voids and bubbles are considerably smaller than the laser wavelength, the scattered light is in the Rayleigh regime, which allows for the detection of early stage cavitation. Simple estimates of the scattered radiation intensity and the dynamics of its changes in connection with the generation of cavitation in the test volume are obtained, allowing us to find the critical conditions for cavitation inception. PMID:26977641

  17. Photoacoustic cavitation for theranostics: mechanism, current progress and applications

    NASA Astrophysics Data System (ADS)

    Feng, Y.; Qin, D.; Wan, M.

    2015-12-01

    As an emerging cavitation technology, photoacoustic cavitation (PAC) means the formation of bubbles in liquids using focused laser and pre-established ultrasound synchronously. Its significant advantages include the decreased threshold of each modality and the precise location of cavitation determined by the focused laser. In this paper, a brief review of PAC is presented, including the physical mechanism description, the classic experimental technology, the representative results in variety of media, and its applications in biomedical imaging and therapy. Moreover, some preliminary results of PAC in perfluoropentane (PFP) liquid and PFP droplets investigated by passive cavitation detection (PCD) in our group are also presented.

  18. Effect of vibration amplitude on vapor cavitation in journal bearings

    NASA Technical Reports Server (NTRS)

    Brewe, D. E.; Jacobson, B. O.

    1986-01-01

    Computational movies were used to analyze the formation and collapse of vapor cavitation bubbles in a submerged journal bearing. The effect of vibration amplitude on vapor cavitation was studied for a journal undergoing circular whirl. The boundary conditions were implemented using Elrod's algorithm, which conserves mass flow through the cavitation bubble as well as through the oil-film region of the bearing. The vibration amplitudes for the different cases studied resulted in maximum eccentricity ratios ranging from 0.4 to 0.9. The minimum eccentricity ratio reached in each case was 0.1. For the least vibration amplitude studied in which the eccentricity ratio varied between 0.1 and 0.4, no vapor cavitation occurred. The largest vibration amplitude (i.e., eccentricity ratios of 0.1 to 0.9) resulted in vapor cavitation present 76 percent of one complete orbit.

  19. Study on cavitation behavior during high-intensity focused ultrasound exposure by using optical and ultrasonic imaging

    NASA Astrophysics Data System (ADS)

    Taguchi, Kei; Takagi, Ryo; Yasuda, Jun; Yoshizawa, Shin; Umemura, Shin-ichiro

    2016-07-01

    Cavitation bubbles are known to enhance the heating effect of high-intensity focused ultrasound (HIFU). In our previous study, the use of a “triggered HIFU” sequence consisting of a high-intensity pulse and a relatively low-intensity burst was proposed as an effective method to utilize the effect of cavitation bubbles. However, the duration of each component in the sequence has not been optimized. In this study, optical imaging was carried out to observe the behavior of cavitation bubbles in a gel phantom during the triggered HIFU exposure. Ultrasound imaging using the pulse inversion method was also conducted to detect the behavior of the bubbles. The results suggest that the oscillation of cavitation bubbles become inactive as the duration of HIFU burst exposure increases to the order of 10 ms. It was also suggested that ultrasonic imaging has potential use for detecting a change in the oscillation of cavitation bubbles for optimizing a triggered HIFU sequence.

  20. Analogy between fluid cavitation and fracture mechanics

    NASA Technical Reports Server (NTRS)

    Hendricks, R. C.; Mullen, R. L.; Braun, M. J.

    1983-01-01

    When the stresses imposed on a fluid are sufficiently large, rupture or cavitation can occur. Such conditions can exist in many two-phase flow applications, such as the choked flows, which can occur in seals and bearings. Nonspherical bubbles with large aspect ratios have been observed in fluids under rapid acceleration and high shear fields. These bubbles are geometrically similar to fracture surface patterns (Griffith crack model) existing in solids. Analogies between crack growth in solid and fluid cavitation are proposed and supported by analysis and observation (photographs). Healing phenomena (void condensation), well accepted in fluid mechanics, have been observed in some polymers and hypothesized in solid mechanics. By drawing on the strengths of the theories of solid mechanics and cavitation, a more complete unified theory can be developed.

  1. Optical Measurements of Cavitation in Tribological Contacts

    NASA Astrophysics Data System (ADS)

    Tang, Tian; Morris, Nick; Coupland, Jeremy

    2015-12-01

    The paper describes the use of a white light interformeter to measure the cavitation bubble and oil film thickness in a tribological contact and compares the results to theory. It is found that oil film thickness is best predicted by the theory proposed by Coyne and Elrod.

  2. Review on Lithotripsy and Cavitation in Urinary Stone Therapy.

    PubMed

    Ghorbani, Morteza; Oral, Ozlem; Ekici, Sinan; Gozuacik, Devrim; Kosar, Ali

    2016-01-01

    Cavitation is the sudden formation of vapor bubbles or voids in liquid media and occurs after rapid changes in pressure as a consequence of mechanical forces. It is mostly an undesirable phenomenon. Although the elimination of cavitation is a major topic in the study of fluid dynamics, its destructive nature could be exploited for therapeutic applications. Ultrasonic and hydrodynamic sources are two main origins for generating cavitation. The purpose of this review is to give the reader a general idea about the formation of cavitation phenomenon and existing biomedical applications of ultrasonic and hydrodynamic cavitation. Because of the high number of the studies on ultrasound cavitation in the literature, the main focus of this review is placed on the lithotripsy techniques, which have been widely used for the treatment of urinary stones. Accordingly, cavitation phenomenon and its basic concepts are presented in Section II. The significance of the ultrasound cavitation in the urinary stone treatment is discussed in Section III in detail and hydrodynamic cavitation as an important alternative for the ultrasound cavitation is included in Section IV. Finally, side effects of using both ultrasound and hydrodynamic cavitation in biomedical applications are presented in Section V. PMID:27249837

  3. Acoustically enhanced bubble growth at low frequencies and its implications for human diver and marine mammal safety.

    PubMed

    Crum, L A; Mao, Y

    1996-05-01

    Computations are made of the conditions necessary to obtain bubble growth by rectified diffusion under a variety of conditions associated with low-frequency sonar propagation in the ocean. The complex issue of microbubble nuclei stabilization is treated by assuming either a sufficient level of supersaturation to stabilize the initial bubble size, or by examining a microbubble nucleus with zero surface tension. The bubble growth rates and thresholds are obtained for a ranged of sound-pressure levels (re: 1 microPa) from 150-220 dB, for initial bubble radii from 1-10 microns, and for levels of the dissolved gas concentration from 100% to 223% of saturation. It was determined that for the range of conditions examined, it was necessary to utilize three different formulations of the equations for bubble growth. The results of these calculations (and assumptions concerning nuclei stabilization) indicate that for SPL's in excess of 210 dB, significant bubble growth can be expected to occur, and divers and marine mammals exposed to these conditions could be at risk. For SPL's below about 190 dB, however, except under relatively extreme conditions of supersaturation, significant bubble growth is unexpected.

  4. Removal of Residual Nuclei Following a Cavitation Event using Low-Amplitude Ultrasound

    PubMed Central

    Duryea, Alexander P.; Cain, Charles A.; Tamaddoni, Hedieh A.; Roberts, William W.; Hall, Timothy L.

    2014-01-01

    Microscopic residual bubble nuclei can persist on the order of 1 second following a cavitation event. These bubbles can limit the efficacy of ultrasound therapies such as shock wave lithotripsy and histotripsy, as they attenuate pulses that arrive subsequent to their formation and seed repetitive cavitation activity at a discrete set of sites (cavitation memory). Here, we explore a strategy for the removal of these residual bubbles following a cavitation event, using low amplitude ultrasound pulses to stimulate bubble coalescence. All experiments were conducted in degassed water and monitored using high speed photography. In each case, a 2 MHz histotripsy transducer was used to initiate cavitation activity (a cavitational bubble cloud), the collapse of which generated a population of residual bubble nuclei. This residual nuclei population was then sonicated using a 1 ms pulse from a separate 500 kHz transducer, which we term the ‘bubble removal pulse.’ Bubble removal pulse amplitudes ranging from 0 to 1.7 MPa were tested, and the backlit area of shadow from bubbles remaining in the field following bubble removal was calculated to quantify efficacy. It was found that an ideal amplitude range exists (roughly 180 – 570 kPa) in which bubble removal pulses stimulate the aggregation and subsequent coalescence of residual bubble nuclei, effectively removing them from the field. Further optimization of bubble removal pulse sequences stands to provide an adjunct to cavitation-based ultrasound therapies such as shock wave lithotripsy and histotripsy, mitigating the effects of residual bubble nuclei that currently limit their efficacy. PMID:25265172

  5. Acoustic Droplet Vaporization in Biology and Medicine

    PubMed Central

    Pitt, William G.

    2013-01-01

    This paper reviews the literature regarding the use of acoustic droplet vaporization (ADV) in clinical applications of imaging, embolic therapy, and therapeutic delivery. ADV is a physical process in which the pressure waves of ultrasound induce a phase transition that causes superheated liquid nanodroplets to form gas bubbles. The bubbles provide ultrasonic imaging contrast and other functions. ADV of perfluoropentane was used extensively in imaging for preclinical trials in the 1990s, but its use declined rapidly with the advent of other imaging agents. In the last decade, ADV was proposed and explored for embolic occlusion therapy, drug delivery, aberration correction, and high intensity focused ultrasound (HIFU) sensitization. Vessel occlusion via ADV has been explored in rodents and dogs and may be approaching clinical use. ADV for drug delivery is still in preclinical stages with initial applications to treat tumors in mice. Other techniques are still in preclinical studies but have potential for clinical use in specialty applications. Overall, ADV has a bright future in clinical application because the small size of nanodroplets greatly reduces the rate of clearance compared to larger contrast agent bubbles and yet provides the advantages of ultrasonographic contrast, acoustic cavitation, and nontoxicity of conventional perfluorocarbon contrast agent bubbles. PMID:24350267

  6. Observation of cavitation during shock wave lithotripsy

    NASA Astrophysics Data System (ADS)

    Bailey, Michael R.; Crum, Lawrence A.; Pishchalnikov, Yuri A.; McAteer, James A.; Pishchalnikova, Irina V.; Evan, Andrew P.; Sapozhnikov, Oleg A.; Cleveland, Robin O.

    2005-04-01

    A system was built to detect cavitation in pig kidney during shock wave lithotripsy (SWL) with a Dornier HM3 lithotripter. Active detection, using echo on B-mode ultrasound, and passive cavitation detection (PCD), using coincident signals on confocal, orthogonal receivers, were equally sensitive and were used to interrogate the renal collecting system (urine) and the kidney parenchyma (tissue). Cavitation was detected in urine immediately upon SW administration in urine or urine plus X-ray contrast agent, but in tissue, cavitation required hundreds of SWs to initiate. Localization of cavitation was confirmed by fluoroscopy, sonography, and by thermally marking the kidney using the PCD receivers as high intensity focused ultrasound sources. Cavitation collapse times in tissue and native urine were about the same but less than in urine after injection of X-ray contrast agent. Cavitation, especially in the urine space, was observed to evolve from a sparse field to a dense field with strong acoustic collapse emissions to a very dense field that no longer produced detectable collapse. The finding that cavitation occurs in kidney tissue is a critical step toward determining the mechanisms of tissue injury in SWL. [Work sup ported by NIH (DK43881, DK55674, FIRCA), ONRIFO, CRDF and NSBRI SMS00203.

  7. Theory of supercompression of vapor bubbles and nanoscale thermonuclear fusion

    SciTech Connect

    Nigmatulin, Robert I.; Akhatov, Iskander Sh.; Topolnikov, Andrey S.; Bolotnova, Raisa Kh.; Vakhitova, Nailya K.; Lahey, Richard T. Jr.; Taleyarkhan, Rusi P.

    2005-10-01

    This paper provides the theoretical basis for energetic vapor bubble implosions induced by a standing acoustic wave. Its primary goal is to describe, explain, and demonstrate the plausibility of the experimental observations by Taleyarkhan et al. [Science 295, 1868 (2002); Phys. Rev. E 69, 036109 (2004)] of thermonuclear fusion for imploding cavitation bubbles in chilled deuterated acetone. A detailed description and analysis of these data, including a resolution of the criticisms that have been raised, together with some preliminary HYDRO code simulations, has been given by Nigmatulin et al. [Vestnik ANRB (Ufa, Russia) 4, 3 (2002); J. Power Energy 218-A, 345 (2004)] and Lahey et al. [Adv. Heat Transfer (to be published)]. In this paper a hydrodynamic shock (i.e., HYDRO) code model of the spherically symmetric motion for a vapor bubble in an acoustically forced liquid is presented. This model describes cavitation bubble cluster growth during the expansion period, followed by a violent implosion during the compression period of the acoustic cycle. There are two stages of the bubble dynamics process. The first, low Mach number stage, comprises almost all the time of the acoustic cycle. During this stage, the radial velocities are much less than the sound speeds in the vapor and liquid, the vapor pressure is very close to uniform, and the liquid is practically incompressible. This process is characterized by the inertia of the liquid, heat conduction, and the evaporation or condensation of the vapor. The second, very short, high Mach number stage is when the radial velocities are the same order, or higher, than the sound speeds in the vapor and liquid. In this stage high temperatures, pressures, and densities of the vapor and liquid take place. The model presented herein has realistic equations of state for the compressible liquid and vapor phases, and accounts for nonequilibrium evaporation/condensation kinetics at the liquid/vapor interface. There are interacting

  8. Theory of supercompression of vapor bubbles and nanoscale thermonuclear fusion

    NASA Astrophysics Data System (ADS)

    Nigmatulin, Robert I.; Akhatov, Iskander Sh.; Topolnikov, Andrey S.; Bolotnova, Raisa Kh.; Vakhitova, Nailya K.; Lahey, Richard T.; Taleyarkhan, Rusi P.

    2005-10-01

    This paper provides the theoretical basis for energetic vapor bubble implosions induced by a standing acoustic wave. Its primary goal is to describe, explain, and demonstrate the plausibility of the experimental observations by Taleyarkhan et al. [Science 295, 1868 (2002); Phys. Rev. E 69, 036109 (2004)] of thermonuclear fusion for imploding cavitation bubbles in chilled deuterated acetone. A detailed description and analysis of these data, including a resolution of the criticisms that have been raised, together with some preliminary HYDRO code simulations, has been given by Nigmatulin et al. [Vestnik ANRB (Ufa, Russia) 4, 3 (2002); J. Power Energy 218-A, 345 (2004)] and Lahey et al. [Adv. Heat Transfer (to be published)]. In this paper a hydrodynamic shock (i.e., HYDRO) code model of the spherically symmetric motion for a vapor bubble in an acoustically forced liquid is presented. This model describes cavitation bubble cluster growth during the expansion period, followed by a violent implosion during the compression period of the acoustic cycle. There are two stages of the bubble dynamics process. The first, low Mach number stage, comprises almost all the time of the acoustic cycle. During this stage, the radial velocities are much less than the sound speeds in the vapor and liquid, the vapor pressure is very close to uniform, and the liquid is practically incompressible. This process is characterized by the inertia of the liquid, heat conduction, and the evaporation or condensation of the vapor. The second, very short, high Mach number stage is when the radial velocities are the same order, or higher, than the sound speeds in the vapor and liquid. In this stage high temperatures, pressures, and densities of the vapor and liquid take place. The model presented herein has realistic equations of state for the compressible liquid and vapor phases, and accounts for nonequilibrium evaporation/condensation kinetics at the liquid/vapor interface. There are interacting

  9. Cavitation measurements on a pump-turbine model

    NASA Astrophysics Data System (ADS)

    Schmidt, H.; Kirschner, O.; Riedelbauch, S.

    2015-12-01

    When a hydraulic turbine is operated at off-design conditions, cavitation on the runner and other machine parts can occur. Vibration, noise and erosion caused by cavitation can damage the turbine and lead to a limitation of the operational range. To avoid damage of the turbine, it is fundamental to get knowledge of the presence of cavitation. In this paper, the acoustic emissions at a pump-turbine model at different operating conditions with and without the presence of cavitation were recorded and analysed. High speed video recordings were carried out simultaneously to validate the acoustic measurements. The main goal of the investigation was to compare the acoustic emissions with the visual observations at operating conditions with cavitation on the leading edge of the turbine runner. The analysis of the recorded signals and the visual observations are in good accordance for the investigated operating points.

  10. Periodic cavitation shedding in a cylindrical orifice

    NASA Astrophysics Data System (ADS)

    Stanley, C.; Barber, T.; Milton, B.; Rosengarten, G.

    2011-11-01

    Cavitation structures in a large-scale ( D = 8.25 mm), plain orifice style nozzle within a unique experimental rig are investigated using high-speed visualisation and digital image processing techniques. Refractive index matching with an acrylic nozzle is achieved using aqueous sodium iodide for the test fluid. Cavitation collapse length, unsteady shedding frequency and spray angles are measured for cavitation conditions from incipient to supercavitation for a range of Reynolds numbers, for a fixed L/ D ratio of 4.85. Periodic cavitation shedding was shown to occur with frequencies between 500 and 2,000 Hz for conditions in which cavitation occupied less than 30% of the nozzle length. A discontinuity in collapse length was shown to occur once the cavitation exceeded this length, coinciding with a loss of periodic shedding. A mechanism for this behaviour is discussed. Peak spray angles of approximately θ ≈ 14° were recorded for supercavitation conditions indicating the positive influence of cavitation bubble collapse on the jet atomisation process.

  11. Bursting Bubbles and Bilayers

    PubMed Central

    Wrenn, Steven P.; Dicker, Stephen M.; Small, Eleanor F.; Dan, Nily R.; Mleczko, Michał; Schmitz, Georg; Lewin, Peter A.

    2012-01-01

    This paper discusses various interactions between ultrasound, phospholipid monolayer-coated gas bubbles, phospholipid bilayer vesicles, and cells. The paper begins with a review of microbubble physics models, developed to describe microbubble dynamic behavior in the presence of ultrasound, and follows this with a discussion of how such models can be used to predict inertial cavitation profiles. Predicted sensitivities of inertial cavitation to changes in the values of membrane properties, including surface tension, surface dilatational viscosity, and area expansion modulus, indicate that area expansion modulus exerts the greatest relative influence on inertial cavitation. Accordingly, the theoretical dependence of area expansion modulus on chemical composition - in particular, poly (ethylene glyclol) (PEG) - is reviewed, and predictions of inertial cavitation for different PEG molecular weights and compositions are compared with experiment. Noteworthy is the predicted dependence, or lack thereof, of inertial cavitation on PEG molecular weight and mole fraction. Specifically, inertial cavitation is predicted to be independent of PEG molecular weight and mole fraction in the so-called mushroom regime. In the “brush” regime, however, inertial cavitation is predicted to increase with PEG mole fraction but to decrease (to the inverse 3/5 power) with PEG molecular weight. While excellent agreement between experiment and theory can be achieved, it is shown that the calculated inertial cavitation profiles depend strongly on the criterion used to predict inertial cavitation. This is followed by a discussion of nesting microbubbles inside the aqueous core of microcapsules and how this significantly increases the inertial cavitation threshold. Nesting thus offers a means for avoiding unwanted inertial cavitation and cell death during imaging and other applications such as sonoporation. A review of putative sonoporation mechanisms is then presented, including those

  12. Simulations of Non-spherical Bubble Collapse Dynamics in Viscous and Viscoelastic Media Near a Compliant Object

    NASA Astrophysics Data System (ADS)

    Rodriguez, Mauro; Johnsen, Eric

    2015-11-01

    Understanding the dynamics of cavitation bubbles and the shock waves emitted by their collapse in and near viscoelastic media is important for various naval and medical applications, particularly in the context of cavitation damage. Two examples are histotripsy, which utilizes this phenomenon for the ablation of pathogenic tissue, and erosion to elastomeric coatings on propellers. Although not fully understood, the damage mechanism combines the effect of the incoming pulses and cavitation produced by the high tension. Additionally, the influence of the shock on the material and the response of the material to the shock are not well known. A novel numerical approach for simulating shock and acoustic wave propagation in Zener-like viscoelastic media is proposed. This Eulerian method is based on a high-order accurate weighted essentially non-oscillatory scheme for shock capturing and introduces evolution equations for the components of the shear stress tensor. Validation studies between high-fidelity two-dimensional simulations of the bubble collapse dynamics for various experimental configurations (i.e. the viscous or viscoelastic material surrounding the bubble and the nearby compliant object are varied) will be presented. This work is supported by ONR grant N00014-12-1-0751.

  13. PIV Analysis of Cavitation Flow Characteristics of He II

    SciTech Connect

    Harada, K.; Murakami, M.

    2006-04-27

    In the present experimental study cavitation phenomena in both He I and He II flows were investigated through the application of the PIV technique and visual observation under the saturated vapor pressure condition. The cavitation flow was generated in the downstream regions of a Venturi channel and a converging jet nozzle driven by a contracting metal bellows. It is seen that cavitation inception is a kind of stochastic process and has definite temperature dependence. The spatial distribution of the cavitation bubble velocity is measured by using the PIV technique. Some differences in the cavitating flow pattern and the void fraction are found between He II and He I cavitating flows. The PIV result indicates that the void fraction for He II flow is larger than that for He I flow.

  14. Cavitation nucleation

    NASA Astrophysics Data System (ADS)

    Crum, Lawrence A.

    2001-05-01

    For his dissertation research at Harvard, Bob Apfel chose the subject of homogeneous nucleation, and conceived of some ingenious experiments to test existing theories. By selecting a small microdroplet of liquid, he could make the reasonable assumption that no inhomogeneities were present to serve as preferential sites for liquid rupture. However, Bob also studied dirty liquids, as well as very clean ones, and wrote some seminal papers on inhomogeneous nucleation, in which he developed the Golden rule: Know thy liquid! Currently, considerable attention has been devoted to the study of cavitation generation in vivo, particularly in blood, and, for this case, the nucleation conditions are much different than those for normal liquids. In this presentation, I will review some of Bob's pioneering studies and present some of our latest studies of cavitation inception, both in vitro and in vivo.

  15. Putting technology to work in reducing cavitation damage

    SciTech Connect

    Shanahan, T.B.

    1995-09-01

    Cavitation has been a persistent problem on the large-sized hydro generating units at the 10,300-MW Guri project in Venezuela. Project owners used a state-of-the-art acoustic testing program to determine power ranges that would minimize cavitation damage while meeting operating goals.

  16. Numerical simulation on the cavitation of waterjet propulsion pump

    NASA Astrophysics Data System (ADS)

    Xia, C. Z.; Cheng, L.; Shang, Y. N.; Zhou, J. R.; Yang, F.; Jin, Y.

    2016-05-01

    Waterjet propulsion system is widely used in high speed vessels with advantages of simple transmission mechanism, low noise underwater and good manoeuvrability. Compared with the propeller, waterjet propulsion can be used flow stamping to increasing cavitation resistance at high speed. But under certain conditions, such as low ship speed or high ship speed, cavitation problem still exists. If water-jet propulsion pump is run in cavitation condition for a long time, then the cavitation will cause a great deal of noise CFD is applied to analysis and predict the process of production and development of cavitation in waterjet propulsion pump. Based on the cavitation model of Zwart-Gerber-Belamri and a mixture of homogeneous flow model, commercial CFD software CFX was taken for characteristics of cavitation under the three operating conditions. Commercial software ANSYS 14.0 is used to build entity model, mesh and numerical simulation. The grid independence analysis determine the grid number of mixed flow pump model is about 1.6 million and the grid number of water-jet pump system unit is about 2.7 million. The cavitation characteristics of waterjet pump under three operating conditions are studied. The results show that the cavitation development trend is similar design and small rate of flow condition .Under the design conditions Cavitation bubbles are mainly gathered in suction surface of blade near the inlet side of the hub under the primary stage, and gradually extended to the water side in the direction of the rim with the loss of the inlet total pressure. Cavitation appears in hub before the blade rim, but the maximum value of gas content in blade rim is bigger than that in hub. Under large flow conditions, bubble along the direction of wheel hub extends to the rim gradually. Cavitation is found in the pressure surface of blade near the hub region under the critical point of cavitation nearby. When NPSHa is lower than critical point, the area covering by bubbles

  17. Investigations of the Cavitation and Damage Thresholds of Histotripsy and Applications in Targeted Tissue Ablation

    NASA Astrophysics Data System (ADS)

    Vlaisavljevich, Eli

    Histotripsy is a noninvasive ultrasound therapy that controls acoustic cavitation to mechanically fractionate soft tissue. This dissertation investigates the physical thresholds to initiate cavitation and produce tissue damage in histotripsy and factors affecting these thresholds in order to develop novel strategies for targeted tissue ablation. In the first part of this dissertation, the effects of tissue properties on histotripsy cavitation thresholds and damage thresholds were investigated. Results demonstrated that the histotripsy shock scattering threshold using multi-cycle pulses increases in stiffer tissues, while the histotripsy intrinsic threshold using single-cycle pulses is independent of tissue stiffness. Further, the intrinsic threshold slightly decreases with lower frequencies and significantly decreases with increasing temperature. The effects of tissue properties on the susceptibility to histotripsy-induced tissue damage were also investigated, demonstrating that stiffer tissues are more resistant to histotripsy. Two strategies were investigated for increasing the effectiveness of histotripsy for the treatment of stiffer tissues, with results showing that thermal preconditioning may be used to alter tissue susceptibility to histotripsy and that lower frequency treatments may increase the efficiency of histotripsy tissue ablation due to enhanced bubble expansion. In the second part of this dissertation, the feasibility of using histotripsy for targeted liver ablation was investigated in an intact in vivo porcine model, with results demonstrating that histotripsy was capable of non-invasively creating precise lesions throughout the entire liver. Additionally, a tissue selective ablation approach was developed, where histotripsy completely fractionated the liver tissue surrounding the major hepatic vessels and gallbladder while being self-limited at the boundaries of these critical structures. Finally, the long-term effects of histotripsy liver

  18. A cavitation model for computations of unsteady cavitating flows

    NASA Astrophysics Data System (ADS)

    Zhao, Yu; Wang, Guoyu; Huang, Biao

    2016-04-01

    A local vortical cavitation (LVC) model for the computation of unsteady cavitation is proposed. The model is derived from the Rayleigh-Plesset equations, and takes into account the relations between the cavitation bubble radius and local vortical effects. Calculations of unsteady cloud cavitating flows around a Clark-Y hydrofoil are performed to assess the predictive capability of the LVC model using well-documented experimental data. Compared with the conventional Zwart's model, better agreement is observed between the predictions of the LVC model and experimental data, including measurements of time-averaged flow structures, instantaneous cavity shapes and the frequency of the cloud cavity shedding process. Based on the predictions of the LVC model, it is demonstrated that the evaporation process largely concentrates in the core region of the leading edge vorticity in accordance with the growth in the attached cavity, and the condensation process concentrates in the core region of the trailing edge vorticity, which corresponds to the spread of the rear component of the attached cavity. When the attached cavity breaks up and moves downstream, the condensation area fully transports to the wake region, which is in accordance with the dissipation of the detached cavity. Furthermore, using vorticity transport equations, we also find that the periodic formation, breakup, and shedding of the sheet/cloud cavities, along with the associated baroclinic torque, are important mechanisms for vorticity production and modification. When the attached cavity grows, the liquid-vapour interface that moves towards the trailing edge enhances the vorticity in the attached cavity closure region. As the re-entrant jet moves upstream, the wavy/bubbly cavity interface enhances the vorticity near the trailing edge. At the end of the cycle, the break-up of the stable attached cavity is the main reason for the vorticity enhancement near the suction surface.

  19. Bubble in a corner flow

    NASA Technical Reports Server (NTRS)

    Vanden-Broeck, J. M.

    1982-01-01

    The distortion of a two-dimensional bubble (or drop) in a corner of angle delta, due to the flow of an inviscid incompressible fluid around it, is examined theoretically. The flow and the bubble shape are determined as functions of the angle delta, the contact angle beta and the cavitation number gamma. The problem is formulated as an integrodifferential equation for the bubble surface. This equation generalized the integrodifferential equations derived by Vanden-Broeck and Keller. The shape of the bubble is found approximately by using the slender body theory for bubbles. When gamma reaches a critical value gamma sub 0 (beta, delta), opposite sides of the bubble touch each other. Two different families of solution for gamma gamma sub 0 are obtained. In the first family opposite sides touch at one point. In the second family contact is allowed along a segment.

  20. Evaporation-induced cavitation in nanofluidic channels

    PubMed Central

    Duan, Chuanhua; Karnik, Rohit; Lu, Ming-Chang; Majumdar, Arun

    2012-01-01

    Cavitation, known as the formation of vapor bubbles when liquids are under tension, is of great interest both in condensed matter science as well as in diverse applications such as botany, hydraulic engineering, and medicine. Although widely studied in bulk and microscale-confined liquids, cavitation in the nanoscale is generally believed to be energetically unfavorable and has never been experimentally demonstrated. Here we report evaporation-induced cavitation in water-filled hydrophilic nanochannels under enormous negative pressures up to -7 MPa. As opposed to receding menisci observed in microchannel evaporation, the menisci in nanochannels are pinned at the entrance while vapor bubbles form and expand inside. Evaporation in the channels is found to be aided by advective liquid transport, which leads to an evaporation rate that is an order of magnitude higher than that governed by Fickian vapor diffusion in macro- and microscale evaporation. The vapor bubbles also exhibit unusual motion as well as translational stability and symmetry, which occur because of a balance between two competing mass fluxes driven by thermocapillarity and evaporation. Our studies expand our understanding of cavitation and provide new insights for phase-change phenomena at the nanoscale. PMID:22343530

  1. Numerical study on the effective heating due to inertial cavitation in microbubble-enhanced HIFU therapy

    NASA Astrophysics Data System (ADS)

    Okita, Kohei; Sugiyama, Kazuyasu; Takagi, Shu; Matsumoto, Yoichiro

    2015-10-01

    The enhancement of heating due to inertial cavitation was focused in high-intensity focused ultrasound (HIFU) therapy. The influences of the rectified diffusion on microbubble-enhanced HIFU were examined numerically. A bubble dynamics equation in consideration of the spherical shell bubble and the elasticity of surrounding tissue was employed. Mass and heat transfer between the surrounding medium and the bubble were considered. The basic equations were discretized by finite difference method. The mixture phase and bubbles are coupled by the Euler-Lagrange method to take into account the interaction between ultrasound and bubbles. The mass transfer rate of gas from the surrounding medium to the bubble was examined as function of the initial bubble radius and the driving pressure amplitude. As the results, the pressure required to bubble growth was decreases with increasing the initial bubble radius. Thus, the injection of microbubble reduces the cavitation threshold pressure. On the other hand, the influence of the rectified diffusion on the triggered HIFU therapy which generates cavitation bubbles by high-intensity burst and induces the localized heating owing to cavitation bubble oscillation by low-intensity continuous waves. The calculation showed that the localized heating was enhanced by the increase of the equilibrium bubble size due to the rectified diffusion.

  2. Towards numerical prediction of cavitation erosion

    PubMed Central

    Fivel, Marc; Franc, Jean-Pierre; Chandra Roy, Samir

    2015-01-01

    This paper is intended to provide a potential basis for a numerical prediction of cavitation erosion damage. The proposed method can be divided into two steps. The first step consists in determining the loading conditions due to cavitation bubble collapses. It is shown that individual pits observed on highly polished metallic samples exposed to cavitation for a relatively small time can be considered as the signature of bubble collapse. By combining pitting tests with an inverse finite-element modelling (FEM) of the material response to a representative impact load, loading conditions can be derived for each individual bubble collapse in terms of stress amplitude (in gigapascals) and radial extent (in micrometres). This step requires characterizing as accurately as possible the properties of the material exposed to cavitation. This characterization should include the effect of strain rate, which is known to be high in cavitation erosion (typically of the order of several thousands s−1). Nanoindentation techniques as well as compressive tests at high strain rate using, for example, a split Hopkinson pressure bar test system may be used. The second step consists in developing an FEM approach to simulate the material response to the repetitive impact loads determined in step 1. This includes a detailed analysis of the hardening process (isotropic versus kinematic) in order to properly account for fatigue as well as the development of a suitable model of material damage and failure to account for mass loss. Although the whole method is not yet fully operational, promising results are presented that show that such a numerical method might be, in the long term, an alternative to correlative techniques used so far for cavitation erosion prediction. PMID:26442139

  3. Towards numerical prediction of cavitation erosion.

    PubMed

    Fivel, Marc; Franc, Jean-Pierre; Chandra Roy, Samir

    2015-10-01

    This paper is intended to provide a potential basis for a numerical prediction of cavitation erosion damage. The proposed method can be divided into two steps. The first step consists in determining the loading conditions due to cavitation bubble collapses. It is shown that individual pits observed on highly polished metallic samples exposed to cavitation for a relatively small time can be considered as the signature of bubble collapse. By combining pitting tests with an inverse finite-element modelling (FEM) of the material response to a representative impact load, loading conditions can be derived for each individual bubble collapse in terms of stress amplitude (in gigapascals) and radial extent (in micrometres). This step requires characterizing as accurately as possible the properties of the material exposed to cavitation. This characterization should include the effect of strain rate, which is known to be high in cavitation erosion (typically of the order of several thousands s(-1)). Nanoindentation techniques as well as compressive tests at high strain rate using, for example, a split Hopkinson pressure bar test system may be used. The second step consists in developing an FEM approach to simulate the material response to the repetitive impact loads determined in step 1. This includes a detailed analysis of the hardening process (isotropic versus kinematic) in order to properly account for fatigue as well as the development of a suitable model of material damage and failure to account for mass loss. Although the whole method is not yet fully operational, promising results are presented that show that such a numerical method might be, in the long term, an alternative to correlative techniques used so far for cavitation erosion prediction. PMID:26442139

  4. Detailed Jet Dynamics in a Collapsing Bubble

    NASA Astrophysics Data System (ADS)

    Supponen, Outi; Obreschkow, Danail; Kobel, Philippe; Farhat, Mohamed

    2015-12-01

    We present detailed visualizations of the micro-jet forming inside an aspherically collapsing cavitation bubble near a free surface. The high-quality visualizations of large and strongly deformed bubbles disclose so far unseen features of the dynamics inside the bubble, such as a mushroom-like flattened jet-tip, crown formation and micro-droplets. We also find that jetting near a free surface reduces the collapse time relative to the Rayleigh time.

  5. Cavitation dynamics and directional microbubble ejection induced by intense femtosecond laser pulses in liquids.

    PubMed

    Faccio, D; Tamošauskas, G; Rubino, E; Darginavičius, J; Papazoglou, D G; Tzortzakis, S; Couairon, A; Dubietis, A

    2012-09-01

    We study cavitation dynamics when focusing ring-shaped femtosecond laser beams in water. This focusing geometry reduces detrimental nonlinear beam distortions and enhances energy deposition within the medium, localized at the focal spot. We observe remarkable postcollapse dynamics of elongated cavitation bubbles with high-speed ejection of microbubbles out of the laser focal region. Bubbles are ejected along the laser axis in both directions (away and towards the laser). The initial shape of the cavitation bubble is also seen to either enhance or completely suppress jet formation during collapse. In the absence of jetting, microbubble ejection occurs orthogonal to the laser propagation axis.

  6. Study on Prediction of Underwater Radiated Noise from Propeller Tip Vortex Cavitation

    NASA Astrophysics Data System (ADS)

    Yamada, Takuyoshi; Sato, Kei; Kawakita, Chiharu; Oshima, Akira

    2015-12-01

    The method to predict underwater radiated noise from tip vortex cavitation was studied. The growth of a single cavitation bubble in tip vortex was estimated by substituting the tip vortex to Rankine combined vortex. The ideal spectrum function for the sound pressure generated by a single cavitation bubble was used, also the empirical factor for the number of collapsed bubbles per unit time was introduced. The estimated noise data were compared with measured ship's ones and it was found out that this method can estimate noise data within 3dB difference.

  7. High-speed motion picture camera experiments of cavitation in dynamically loaded journal bearings

    NASA Technical Reports Server (NTRS)

    Jacobson, B. O.; Hamrock, B. J.

    1982-01-01

    A high-speed camera was used to investigate cavitation in dynamically loaded journal bearings. The length-diameter ratio of the bearing, the speeds of the shaft and bearing, the surface material of the shaft, and the static and dynamic eccentricity of the bearing were varied. The results reveal not only the appearance of gas cavitation, but also the development of previously unsuspected vapor cavitation. It was found that gas cavitation increases with time until, after many hundreds of pressure cycles, there is a constant amount of gas kept in the cavitation zone of the bearing. The gas can have pressures of many times the atmospheric pressure. Vapor cavitation bubbles, on the other hand, collapse at pressures lower than the atmospheric pressure and cannot be transported through a high-pressure zone, nor does the amount of vapor cavitation in a bearing increase with time. Analysis is given to support the experimental findings for both gas and vapor cavitation.

  8. Anticipatory model of cavitation

    NASA Astrophysics Data System (ADS)

    Kercel, Stephen W.; Allgood, Glenn O.; Dress, William B.; Hylton, James O.

    1999-03-01

    The Anticipatory System (AS) formalism developed by Robert Rosen provides some insight into the problem of embedding intelligent behavior in machines. AS emulates the anticipatory behavior of biological systems. AS bases its behavior on its expectations about the near future and those expectations are modified as the system gains experience. The expectation is based on an internal model that is drawn from an appeal to physical reality. To be adaptive, the model must be able to update itself. To be practical, the model must run faster than real-time. The need for a physical model and the requirement that the model execute at extreme speeds, has held back the application of AS to practical problems. Two recent advances make it possible to consider the use of AS for practical intelligent sensors. First, advances in transducer technology make it possible to obtain previously unavailable data from which a model can be derived. For example, acoustic emissions (AE) can be fed into a Bayesian system identifier that enables the separation of a weak characterizing signal, such as the signature of pump cavitation precursors, from a strong masking signal, such as a pump vibration feature. The second advance is the development of extremely fast, but inexpensive, digital signal processing hardware on which it is possible to run an adaptive Bayesian-derived model faster than real-time. This paper reports the investigation of an AS using a model of cavitation based on hydrodynamic principles and Bayesian analysis of data from high-performance AE sensors.

  9. Influence of the empirical coefficients of cavitation model on predicting cavitating flow in the centrifugal pump

    NASA Astrophysics Data System (ADS)

    Liu, Hou-lin; Wang, Jian; Wang, Yong; Zhang, Hua; Huang, Haoqin

    2014-03-01

    The phenomenon of cavitation is an unsteady flow, which is nearly inevitable in pump. It would degrade the pump performance, produce vibration and noise and even damage the pump. Hence, to improve accuracy of the nu¬merical prediction of the pump cavitation performance is much desirable. In the present work, a homogenous model, the Zwart-Gerber-Belamri cavitation model, is considered to investigate the influence of the empirical coefficients on predicting the pump cavitation performance, concerning a centrifugal pump. Three coefficients are analyzed, namely the nucleation site radius, evaporation and condensation coefficients. Also, the experiments are carried out to validate the numerical simulations. The results indicate that, to get a precise prediction, the approaches of declining the initial bubble radius, the condensation coefficient or increasing the evaporation coefficient are all feasible, especially for de¬clining the condensation coefficient, which is the most effective way.

  10. Mass spectrometric sampling of a liquid surface by nanoliter droplet generation from bursting bubbles and focused acoustic pulses: application to studies of interfacial chemistry.

    PubMed

    Thomas, Daniel A; Wang, Lingtao; Goh, Byoungsook; Kim, Eun Sok; Beauchamp, J L

    2015-03-17

    The complex chemistry occurring at the interface between liquid and vapor phases contributes significantly to the dynamics and evolution of numerous chemical systems of interest, ranging from damage to the human lung surfactant layer to the aging of atmospheric aerosols. This work presents two methodologies to eject droplets from a liquid water surface and analyze them via mass spectrometry. In bursting bubble ionization (BBI), droplet ejection is achieved via the formation of a jet following bubble rupture at the surface of a liquid to yield 250 μm diameter droplets (10 nL volume). In interfacial sampling by an acoustic transducer (ISAT), droplets are produced by focusing pulsed piezoelectric transducer-generated acoustic waves at the surface of a liquid, resulting in the ejection of droplets of 100 μm in diameter (500 pL volume). In both experimental methodologies, ejected droplets are aspirated into the inlet of the mass spectrometer, resulting in the facile formation of gas-phase ions. We demonstrate the ability of this technique to readily generate spectra of surface-active analytes, and we compare the spectra to those obtained by electrospray ionization. Charge measurements indicate that the ejected droplets are near-neutral (<0.1% of the Rayleigh limit), suggesting that gas-phase ion generation occurs in the heated transfer capillary of the instrument in a mechanism similar to thermospray or sonic spray ionization. Finally, we present the oxidation of oleic acid by ozone as an initial demonstration of the ability of ISAT-MS to monitor heterogeneous chemistry occurring at a planar water/air interface. PMID:25699657

  11. Mass spectrometric sampling of a liquid surface by nanoliter droplet generation from bursting bubbles and focused acoustic pulses: application to studies of interfacial chemistry.

    PubMed

    Thomas, Daniel A; Wang, Lingtao; Goh, Byoungsook; Kim, Eun Sok; Beauchamp, J L

    2015-03-17

    The complex chemistry occurring at the interface between liquid and vapor phases contributes significantly to the dynamics and evolution of numerous chemical systems of interest, ranging from damage to the human lung surfactant layer to the aging of atmospheric aerosols. This work presents two methodologies to eject droplets from a liquid water surface and analyze them via mass spectrometry. In bursting bubble ionization (BBI), droplet ejection is achieved via the formation of a jet following bubble rupture at the surface of a liquid to yield 250 μm diameter droplets (10 nL volume). In interfacial sampling by an acoustic transducer (ISAT), droplets are produced by focusing pulsed piezoelectric transducer-generated acoustic waves at the surface of a liquid, resulting in the ejection of droplets of 100 μm in diameter (500 pL volume). In both experimental methodologies, ejected droplets are aspirated into the inlet of the mass spectrometer, resulting in the facile formation of gas-phase ions. We demonstrate the ability of this technique to readily generate spectra of surface-active analytes, and we compare the spectra to those obtained by electrospray ionization. Charge measurements indicate that the ejected droplets are near-neutral (<0.1% of the Rayleigh limit), suggesting that gas-phase ion generation occurs in the heated transfer capillary of the instrument in a mechanism similar to thermospray or sonic spray ionization. Finally, we present the oxidation of oleic acid by ozone as an initial demonstration of the ability of ISAT-MS to monitor heterogeneous chemistry occurring at a planar water/air interface.

  12. The bubble-dependent mechanism of FUS-induced blood-brain barrier opening in mice and in monkeys in vivo

    NASA Astrophysics Data System (ADS)

    Tung, Yao-Sheng; Marquet, Fabrice; Vlachos, Fotios; Feshitan, Jameel A.; Borden, Mark A.; Konofagou, Elisa E.

    2012-10-01

    The blood-brain barrier (BBB) prevents most neurological drugs from traversing from the cerebral microvasculature into the brain parenchyma. Previous studies have shown that the presence of bubbles in an acoustic field temporarily opens the BBB. The BBB opening pressure threshold was previously identified to lie between 0.30 and 0.46 MPa in the case of the smaller bubbles and between 0.15 and 0.30 MPa in the larger bubble case. However, the physical effects responsible for BBB opening remain unknown. In addition, the noninvasive in vivo cavitation detection with mono-dispersed microbubbles has not been studied as of yet. The purpose of this study is to unveil the physical mechanism of the FUS-induced BBB opening with monodispersed microbubbles. Lipid-shelled microbubbles with three different diameters (1-2, 4-5 and 6-8 μm) were manufactured in-house and size-isolated using differential centrifugation. Sixty-seven (n=67) mice were each injected intravenously with bubbles of either 1-2, 4-5 or 6-8 μm in diameter and the concentration of 107 numbers/mL. The right hippocampus of each mouse was then sonicated using focused ultrasound (1.5 MHz frequency; 100 cycles (67 μs) pulse length; 10 Hz pulse repetition frequency; 1 minute sonication duration) while the left hippocampus served as the control. A 10-MHz transducer was used as a passive cavitation detector (PCD) to determine the threshold of inertial cavitation (IC). Each mouse was sonicated at a specific acoustic peak-rarefactional pressure at 0.15, 0.30, 0.45 or 0.60 MPa in order to identify the threshold of BBB opening and IC. T1-weighted MRI was used to verify the BBB opening and spectrograms were generated in order to detect the IC onset and duration. Our results suggest that the BBB opens as a result of nonlinear (harmonic) bubble oscillation when the bubble diameter is similar to the capillary diameter and with inertial cavitation when it is not. The bubble may thus have to be in contact with the capillary

  13. Modèle multi-bulles pour la cavitation

    NASA Astrophysics Data System (ADS)

    Adama Maiga, Mahamadou; Buisine, Daniel

    2009-11-01

    In this study we propose new multi-bubble model for cavitation, in which, to simulate the interactions within a cloud of cavitation at the initial stage, the dynamic behaviour of two nonidentical bubbles localised in a volume of control is studied. The presence of two bubbles introduces an instability in which the exchange of volume seems an additional degree of freedom. Depending on the conditions of expansion, the small bubble can disappear or not. If the small bubble disappears, the volume of control is readjusted to introduce a new small bubble and to continue calculation in a new sequence. The model makes it possible for many small bubbles to disappear as in the appearance of cavitation, which is at the origin of certain phenomena observed in the zone of the appearance, such as emission of the noise. The model reveals especially the pressure rather like a result than a datum. The comparison of the size of the bubbles and the pressure varying in time, obtained with the model are coherent with the measurements taken by Ohl [Phys. Fluids 14 (10) (2002) 3512-3521]. To cite this article: M. Adama Maiga, D. Buisine, C. R. Mecanique 337 (2009).

  14. Relating xylem cavitation to transpiration in cotton

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Acoustic emmisions (AEs) from xylem cavitation events are characteristic of transpiration processes. Even though a body of work employing AE exists with a large number of species, cotton and other agronomically important crops have either not been investigated, or limited information exists. A few s...

  15. Hydrodynamic Nuclei Concentration Technique in Cavitation Research and Comparison to Phase-Doppler Measurements

    NASA Astrophysics Data System (ADS)

    Ebert, Eric; Kröger, Willfried; Damaschke, Nils

    2015-12-01

    Small particles, especially bubbles in the micro-meter range, influence the cavitation of the propellers. The prediction of cavitation inception and water quality measurements are important in cavitation research. The Hydrodynamic Nuclei Concentration (HDNC) technique can be used for reliable bubble concentration measurements in fluid flows. The HDNC technique bases on the analysis of scattered light from the cavitation nuclei in the water. The HDNC technique can distinguish between bubbles and solid particles. The particle type classification is important, because the number concentration of solid particles is often much higher than the nuclei concentration in cavitation tunnels and in seawater. Verification experiments show, that the HDNC technique reaches similar capabilities in number concentration estimation as Phase Doppler (PD) technique in much shorter acquisition time.

  16. High Speed Imaging of Cavitation around Dental Ultrasonic Scaler Tips.

    PubMed

    Vyas, Nina; Pecheva, Emilia; Dehghani, Hamid; Sammons, Rachel L; Wang, Qianxi X; Leppinen, David M; Walmsley, A Damien

    2016-01-01

    Cavitation occurs around dental ultrasonic scalers, which are used clinically for removing dental biofilm and calculus. However it is not known if this contributes to the cleaning process. Characterisation of the cavitation around ultrasonic scalers will assist in assessing its contribution and in developing new clinical devices for removing biofilm with cavitation. The aim is to use high speed camera imaging to quantify cavitation patterns around an ultrasonic scaler. A Satelec ultrasonic scaler operating at 29 kHz with three different shaped tips has been studied at medium and high operating power using high speed imaging at 15,000, 90,000 and 250,000 frames per second. The tip displacement has been recorded using scanning laser vibrometry. Cavitation occurs at the free end of the tip and increases with power while the area and width of the cavitation cloud varies for different shaped tips. The cavitation starts at the antinodes, with little or no cavitation at the node. High speed image sequences combined with scanning laser vibrometry show individual microbubbles imploding and bubble clouds lifting and moving away from the ultrasonic scaler tip, with larger tip displacement causing more cavitation. PMID:26934340

  17. High Speed Imaging of Cavitation around Dental Ultrasonic Scaler Tips

    PubMed Central

    Vyas, Nina; Pecheva, Emilia; Dehghani, Hamid; Sammons, Rachel L.; Wang, Qianxi X.; Leppinen, David M.; Walmsley, A. Damien

    2016-01-01

    Cavitation occurs around dental ultrasonic scalers, which are used clinically for removing dental biofilm and calculus. However it is not known if this contributes to the cleaning process. Characterisation of the cavitation around ultrasonic scalers will assist in assessing its contribution and in developing new clinical devices for removing biofilm with cavitation. The aim is to use high speed camera imaging to quantify cavitation patterns around an ultrasonic scaler. A Satelec ultrasonic scaler operating at 29 kHz with three different shaped tips has been studied at medium and high operating power using high speed imaging at 15,000, 90,000 and 250,000 frames per second. The tip displacement has been recorded using scanning laser vibrometry. Cavitation occurs at the free end of the tip and increases with power while the area and width of the cavitation cloud varies for different shaped tips. The cavitation starts at the antinodes, with little or no cavitation at the node. High speed image sequences combined with scanning laser vibrometry show individual microbubbles imploding and bubble clouds lifting and moving away from the ultrasonic scaler tip, with larger tip displacement causing more cavitation. PMID:26934340

  18. High Speed Imaging of Cavitation around Dental Ultrasonic Scaler Tips.

    PubMed

    Vyas, Nina; Pecheva, Emilia; Dehghani, Hamid; Sammons, Rachel L; Wang, Qianxi X; Leppinen, David M; Walmsley, A Damien

    2016-01-01

    Cavitation occurs around dental ultrasonic scalers, which are used clinically for removing dental biofilm and calculus. However it is not known if this contributes to the cleaning process. Characterisation of the cavitation around ultrasonic scalers will assist in assessing its contribution and in developing new clinical devices for removing biofilm with cavitation. The aim is to use high speed camera imaging to quantify cavitation patterns around an ultrasonic scaler. A Satelec ultrasonic scaler operating at 29 kHz with three different shaped tips has been studied at medium and high operating power using high speed imaging at 15,000, 90,000 and 250,000 frames per second. The tip displacement has been recorded using scanning laser vibrometry. Cavitation occurs at the free end of the tip and increases with power while the area and width of the cavitation cloud varies for different shaped tips. The cavitation starts at the antinodes, with little or no cavitation at the node. High speed image sequences combined with scanning laser vibrometry show individual microbubbles imploding and bubble clouds lifting and moving away from the ultrasonic scaler tip, with larger tip displacement causing more cavitation.

  19. Calcium Is a Major Determinant of Xylem Vulnerability to Cavitation

    PubMed Central

    Herbette, Stephane; Cochard, Herve

    2010-01-01

    Xylem vulnerability to cavitation is a key parameter in the drought tolerance of trees, but little is known about the control mechanisms involved. Cavitation is thought to occur when an air bubble penetrates through a pit wall, and would hence be influenced by the wall's porosity. We first tested the role of wall-bound calcium in vulnerability to cavitation in Fagus sylvatica. Stems perfused with solutions of oxalic acid, EGTA, or sodium phosphate (NaPO4) were found to be more vulnerable to cavitation. The NaPO4-induced increase in vulnerability to cavitation was linked to calcium removal from the wall. In contrast, xylem hydraulic conductance was unaffected by the chemical treatments, demonstrating that the mechanisms controlling vulnerability to cavitation and hydraulic resistance are uncoupled. The NaPO4 solution was then perfused into stems from 13 tree species possessing highly contrasted vulnerability to cavitation. Calcium was found to be a major determinant of between-species differences in vulnerability to cavitation. This was evidenced in angiosperms as well as conifer species, thus supporting the hypothesis of a common mechanism in drought-induced cavitation. PMID:20547703

  20. Theoretical and experimental comparison of vapor cavitation in dynamically loaded journal bearings

    NASA Technical Reports Server (NTRS)

    Brewe, D. E.; Hamrock, B. J.; Jacobson, B. A.

    1985-01-01

    Vapor cavitation for a submerged journal bearing under dynamically loaded conditions was investigated. The observation of vapor cavitation in the laboratory was done by high-speed photography. It was found that vapor cavitation occurs when the tensile stress applied to the oil exceeded the tensile strength of the oil or the binding of the oil to the surface. The theoretical solution to the Reynolds equation is determined numerically using a moving boundary algorithm. This algorithm conserves mass throughout the computational domain including the region of cavitation and its boundaries. An alternating direction implicit (MDI) method is used to effect the time march. A rotor undergoing circular whirl was studied. Predicted cavitation behavior was analyzed by three-dimensional computer graphic movies. The formation, growth, and collapse of the bubble in response to the dynamic conditions is shown. For the same conditions of dynamic loading, the cavitation bubble was studied in the laboratory using high-speed photography.

  1. Development of Luminescent Imaging for Capturing Cavitation in Water on Solid Surface

    NASA Astrophysics Data System (ADS)

    Aikawa, Akihisa; Ando, Jun; Sakaue, Hirotaka

    2012-11-01

    Two-color pressure-sensitive paint (PSP) is applied to a solid surface to capture the cavitation acting on the surface in water. It is found that the luminescent signal increases under a cavitation region. The luminescence change of a PSP can be related to the oxygen quenching. Based on these, we discuss the luminescence increase at the cavitation region related to the oxygen concentration in water and oxygen pressure of a cavitation bubble. To extract the cavitation from an acquired luminescent image, the motion-capturing PSP method is applied. It eliminates the variation in illumination caused by the bubble creations between the PSP-coated surface and the imaging-acquisition instruments. The time-resolved cavitation images on the PSP-coated surface are captured inside an ultrasonicate bath.

  2. Experimental and numerical insights into seismo-acoustic signals generated during the expansion of rising and bursting large gas bubbles in low-viscosity magmas

    NASA Astrophysics Data System (ADS)

    Lane, Stephen; Corder, Steven; James, Michael

    2010-05-01

    Strombolian activity produces gas-rich, magma-poor eruptions suggesting the separation and concentration of volcanic gases within the plumbing system. These gases are assumed to rise as relatively large bubble rafts or individual 'slug' bubbles that can cause detectable seismic activity on interaction with conduit geometry. Rising within the magma column, a gas bubble must expand appreciably in order to maintain magma-static pressure, for instance volume would increase by a factor of c. 200 for a 1 km rise to the magma-atmosphere interface. For a near-conduit-filling gas slug this expansion is one-dimensional (i.e. length-wise) and increases in rate non-linearly on approach to the surface. As they ascend, small gas slugs can expand sufficiently rapidly to maintain approximate magma-static pressure, but large gas slugs become dynamically overpressured. In laboratory experiments, these unsteady flows of gas and liquid generate pressure changes measurable below the gas phase. They also cause apparatus motion that does not apparently relate directly to these changes. Computational fluid dynamic (CFD) simulation of experiments reproduces the pressure changes within the liquid and allows visualisation of the viscous shear force exerted on the conduit wall around and above the slug as it rises and expands. CFD simulations at volcanic scale then give estimates of the various force contributions that could occur in the natural system. During the experiments, pressure change driven by slug expansion and burst was also measured in the ambient atmosphere above the upper liquid surface. We present experimental evidence of a range of burst processes that depend on the degree of gas overpressure in the slug. These processes range from the quiescent formation of a relatively long-lived liquid film that bursts some time after the gas slug has reached the liquid surface, through complex transitional behaviour where the meniscus detaches from the tube walls to form a bubble, to

  3. Numerical simulation of viscous cavitating flow around a ship propeller

    NASA Astrophysics Data System (ADS)

    Zhu, Zhi-Feng; Fang, Shi-Liang; Wang, Xiao-Yan; Meng, Zhao-Wen; Liu, Ping-Xiang; Du, Xuan-Min

    2011-09-01

    In the present study, cavitation and a ship propeller wake are reported by computed fluid dynamics based on viscous multiphase flow theory. Some recent validation results with a hybrid grid based on unsteady Navier-Stokes (N-S) and bubble dynamics equations are presented to predict velocity, pressure and vapor volume fraction in propeller wake in a uniform inflow. Numerical predictions of sheet cavitation, tip vortex cavitation and hub vortex cavitation are in agreement with the experimental data, same as numerical predictions of longitudinal and transversal evolution of the axial velocity. Blade and shaft rate frequency of propeller is well predicted by the computed results of pressure, and tip vortex is the most important to generate the pressure field within the near wake. The overall results indicate that the present approach is reliable for prediction of cavitation and propeller wake on the condition of uniform inflow.

  4. Prediction of cavitation erosion for marine applications

    NASA Astrophysics Data System (ADS)

    Maquil, T.; Yakubov, S.; Rung, T.

    2015-12-01

    The paper presents the development of a cavitation erosion prediction method. The approach is tailored to marine applications and embedded into a VoF-based procedure for the simulation of turbulent flows. Supplementary to the frequently employed Euler-Euler models, Euler-Lagrange approaches are employed to simulate cavitation. The study aims to convey the merits of an Euler-Lagrange approach for erosion simulations. Accordingly, the erosion model is able to separate different damage mechanisms, e.g. micro-jets, single and collective bubble collapse, and also quantifies their contribution to the total damage. Emphasis is devoted to the prediction of the cavitation extend, the influence of compressible effects and the performance of the material damage model in practical applications. Examples included refer to 2D validation test cases and reveal a fair predictive accuracy.

  5. Influence of cathodic and anodic currents on cavitation erosion

    SciTech Connect

    Auret, J.G.; Damm, O.F.R.A.; Wright, G.J. . Div. of Materials Science and Technology); Robinson, F.P.A. . Dept. of Metallurgy and Materials Engineering)

    1993-11-01

    A vibratory-type cavitation test rig was constructed to study the effect of polarizing currents applied to a cavitating body. The generation of gas by electrolysis reduced mechanical damage suffered by a cavitating body because of bubble collapse cushioning. However, the net effect on overall damage depended on several factors, including the intensity of mechanical attack, corrosion rate, and surface geometrical effects. A cathodic current was shown to always decrease the total volume loss rate, but the volume loss rate sometimes was increased and sometimes was reduced in the anodic current range.

  6. Optimization in design of scientific products for purposes of cavitation problems

    NASA Astrophysics Data System (ADS)

    Modorskii, V. Ya.; Gaynutdinova, D. F.; Gergel, V. P.; Barkalov, K. A.

    2016-06-01

    This paper presents an optimized computer simulation of cavitation phenomena that occurs when a piston moves in a closed liquid-filled pipe. We have developed physical and mathematical models in a three-dimensional dynamic setting, found out a dependence of cavitation parameters on vibration parameters and constructed a domain of vibration influence on concentration of air cavitation bubbles. We also detected a maximum that corresponds to a certain combination of vibration kinematic parameters.

  7. AN EFFICIENT TREATMENT STRATEGY FOR HISTOTRIPSY BY REMOVING CAVITATION MEMORY

    PubMed Central

    Wang, Tzu-Yin; Xu, Zhen; Hall, Timothy L.; Fowlkes, J. Brian; Cain, Charles A.

    2012-01-01

    Cavitation memory effects occur when remnants of cavitation bubbles (nuclei) persist in the host medium and act as seeds for subsequent events. In pulsed cavitational ultrasound therapy, or histotripsy, this effect may cause cavitation to repeatedly occur at these seeded locations within a target volume, producing inhomogeneous tissue fractionation or requiring an excess number of pulses to completely homogenize the target volume. We hypothesized that by removing the cavitation memory, i.e., the persistent nuclei, the cavitation bubbles could be induced at random locations in response to each pulse; therefore, complete disruption of a tissue volume may be achieved with fewer pulses. To test the hypothesis, the cavitation memory was passively removed by increasing the intervals between successive pulses, Δt, from 2, 10, 20, 50 and 100, to 200 ms. Histotripsy treatments were performed in red blood cell tissue phantoms and ex vivo livers using 1-MHz ultrasound pulses of 10 cycles at P−/P+ pressure of 21/59 MPa. The phantom study allowed for direct visualization of the cavitation patterns and the lesion development process in real time using high-speed photography; the ex vivo tissue study provided validation of the memory effect in real tissues. Results of the phantom study showed an exponential decrease in the correlation coefficient between cavitation patterns in successive pulses from 0.5 ± 0.1 to 0.1 ± 0.1 as Δt increased from 2–200 ms; correspondingly, the lesion was completely fractionated with significantly fewer pulses for longer Δts. In the tissue study, given the same number of therapy pulses, complete and homogeneous tissue fractionation with well-defined lesion boundaries was achieved only for Δt ≥ 100 ms. These results indicated that the removal of the cavitation memory resulted in more efficient treatments and homogeneous lesions. PMID:22402025

  8. One-way-coupling simulation of cavitation accompanied by high-speed droplet impact

    NASA Astrophysics Data System (ADS)

    Kondo, Tomoki; Ando, Keita

    2016-03-01

    Erosion due to high-speed droplet impact is a crucial issue in industrial applications. The erosion is caused by the water-hammer loading on material surfaces and possibly by the reloading from collapsing cavitation bubbles that appear within the droplet. Here, we simulate the dynamics of cavitation bubbles accompanied by high-speed droplet impact against a deformable wall in order to see whether the bubble collapse is violent enough to give rise to cavitation erosion on the wall. The evolution of pressure waves in a single water (or gelatin) droplet to collide with a deformable wall at speed up to 110 m/s is inferred from simulations of multicomponent Euler flow where phase changes are not permitted. Then, we examine the dynamics of cavitation bubbles nucleated from micron/submicron-sized gas bubble nuclei that are supposed to exist inside the droplet. For simplicity, we perform Rayleigh-Plesset-type calculations in a one-way-coupling manner, namely, the bubble dynamics are determined accordin