Science.gov

Sample records for acp journal club

  1. Modernizing the journal club.

    PubMed

    Dwarakanath, L S; Khan, K S

    2000-06-01

    Traditionally journal clubs provide a forum to learn presentation skills. We propose a new approach to teaching and learning in journal clubs, focusing on literature acquisition and critical appraisal skills. This approach will enable trainees to use journal clubs for personal professional development as well as for application of new knowledge in clinical medicine to improve patients' outcomes.

  2. Redesigning journal club in residency

    PubMed Central

    Al Achkar, Morhaf

    2016-01-01

    The gap between production and implementation of knowledge is the main reason for the suboptimal quality of health care. To eliminate this gap and improve the quality of patient care, journal club (JC) in graduate medical education provides an opportunity for learning the skills of evidence-based medicine. JC, however, continues to face many challenges mainly due to poorly defined goals, inadequate preparation, and lack of interest. This article presents an innovative model to prepare and present JC based on three pillars: dialogical learning through group discussion, mentored residents as peer teachers, and including JC as part of a structured curriculum to learn evidence-based medicine. This engaging model has the potential to transform JC from a moribund session that is daunting for residents into a lively discussion to redefine clinical practice using the most current evidence. PMID:27313486

  3. New Methods for an Undergraduate Journal Club

    ERIC Educational Resources Information Center

    Clark, Jordan M.; Rollins, Adam W.; Smith, Philip

    2014-01-01

    Journal clubs have been used to advance students' scientific skills beyond basic knowledge and comprehension, but students often view the traditional format of analyzing reported data and experimental design as laborious and intimidating. As such, the traditional approach can diminish student engagement and enthusiasm for the value of scientific…

  4. The Prevalence and Practices of Academic Library Journal Clubs

    ERIC Educational Resources Information Center

    Young, Philip; Vilelle, Luke

    2011-01-01

    Increased mention of journal clubs in the library literature and the recent creation of clubs at the authors' institutions sparked curiosity about how widespread they are in academic libraries. An online survey announced on library listservs assessed their prevalence and practices. Library journal clubs promote current awareness, analysis skills,…

  5. Annals of Emergency Medicine Journal Club. Global Emergency Medicine Journal Club: Social media responses to the November 2013 Annals of Emergency Medicine Journal Club.

    PubMed

    Radecki, Ryan P; Rezaie, Salim R; Lin, Michelle

    2014-04-01

    The Annals November 2013 Journal Club issue marked one of the first collaborations with Academic Life in Emergency Medicine, a medical education blog, in an effort to promote a worldwide, transparent, online effort to perform critical appraisals of journal articles. The Global Emergency Medicine Journal Club was hosted on the blog for 1 week during November 18 to 24, 2013, with comments moderated on the blog and on Twitter. This summary article compiles the discussion and insights.

  6. The Use of Journal Clubs in Science Teacher Education

    ERIC Educational Resources Information Center

    Tallman, Karen A.; Feldman, Allan

    2016-01-01

    This qualitative study explored how in a 7-month-long journal club pre- and inservice science teachers engaged with education research literature relevant to their practice to reduce the theory-practice gap. In the journal club they had the opportunity to critique and analyze peer-reviewed science education articles in the context of their…

  7. Journal club: screen, select, probe & evaluate.

    PubMed

    Kanthraj, G R; Srinivas, C R

    2005-01-01

    Postgraduate dermatology training programs like seminars, panel discussions, and case presentations help residents to acquire knowledge. Journal club (JC) exercises help residents to update themselves with the current literature. What article a resident should choose and how a resident should evaluate and analyze an article or critically appraise a topic are issues that are most relevant for the success of a JC. Little guidance is available in the biomedical literature on how to deal with such issues. The objective of this article is to provide guidance to neophytes on dealing with JC exercises in a way that helps them in learning the critical appraisal skills. A review of the literature and of the author's experience in JC exercises will be presented. Knowing the methodology of rapid screening of articles along with the art of evaluating them, coupled with a sound knowledge of epidemiology and bio-statistics, helps a resident to select appropriate articles and discard poorly conceived or designed topics that may not generate interest in JC attendees. Hence, such an approach helps the resident in acquiring new knowledge in the shortest time. Choosing the right topic and then applying the newly obtained information to clinical practice, participants succeed in making the JC a valuable learning experience. Further, such well-formatted JCs help residents to improve the quality of health care delivered to patients.

  8. Social media, medicine and the modern journal club.

    PubMed

    Topf, Joel M; Hiremath, Swapnil

    2015-04-01

    Medical media is changing along with the rest of the media landscape. One of the more interesting ways that medical media is evolving is the increased role of social media in medical media's creation, curation and distribution. Twitter, a microblogging site, has become a central hub for finding, vetting, and spreading this content among doctors. We have created a Twitter journal club for nephrology that primarily provides post-publication peer review of high impact nephrology articles, but additionally helps Twitter users build a network of engaged people with interests in academic nephrology. By following participants in the nephrology journal club, users are able to stock their personal learning network. In this essay we discuss the history of medical media, the role of Twitter in the current states of media and summarize our initial experience with a Twitter journal club.

  9. Journal clubs: a strategy to teach civility to nursing students.

    PubMed

    Kerber, Cindy; Jenkins, Sheryl; Woith, Wendy; Kim, Myoungjin

    2012-05-01

    Incivility affects nurses and nursing students and can negatively influence patient care and the quality of nursing education. The Institute of Medicine, The Joint Commission, and the American Association of Colleges of Nursing recommended implementation of strategies to manage incivility and build social capital. The purpose of this mixed methods study was to explore the influence of a journal club as an educational intervention to build civility and academic integrity among nursing students. Seventy-nine nursing students completed the Nurses' Intervention for Civility Education Questionnaire and the Ways of Coping Questionnaire before and after the Civility Journal Club intervention. Students involved in the Civility Journal Club were more aware of civility and incivility, more likely to be helpful to their peers, and better equipped to cope with episodes of incivility.

  10. A nursing journal club thrives through shared governance.

    PubMed

    Gloeckner, Mary B; Robinson, Carolene B

    2010-01-01

    Promoting professional growth within the practice of nursing is a challenge for nurses in staff development. When that growth includes reading research articles and discussing implications for practice, it is even more difficult to spark interest among frontline clinicians. Most nurses struggle to understand research studies and find reading and critiquing the content intimidating. This article shares the success of a nursing research journal club that was launched through a community hospital's shared governance model. The article will encourage nurses in staff development to implement a journal club that is meaningful to the bedside nurse in all practice areas.

  11. The Use of Journal Clubs in Science Teacher Education

    NASA Astrophysics Data System (ADS)

    Tallman, Karen A.; Feldman, Allan

    2016-04-01

    This qualitative study explored how in a 7-month-long journal club pre- and inservice science teachers engaged with education research literature relevant to their practice to reduce the theory-practice gap. In the journal club they had the opportunity to critique and analyze peer-reviewed science education articles in the context of their classroom practice. Data sources included audio recordings of the meetings; semi-structured pre- and post-interviews of the teachers; focus groups; and artifacts (e.g., journal articles, reflective paper, email exchanges, and researcher's field notes). Data were analyzed using the techniques of grounded theory (Corbin & Strauss in Basics of qualitative research, 3rd ed. Sage, Thousand Oaks, 2008). In addition we used some preconceived categories that we created from existing literature on journal clubs and communities of practice (Newswander & Borrego in European Journal of Engineering Education 34(6): 561-571, 2009; Wenger in Communities of practice: learning, meaning, and identity. Cambridge University Press, Cambridge, 1998) and from our previous research (Tallman & Feldman, 2012). We found that the journal club incorporated the three characteristics of a community of practice (Wenger in Communities of practice: learning, meaning, and identity. Cambridge University Press, Cambridge, 1998) into its functioning (mutual engagement, joint enterprise, and shared repertoire). The teachers mutually engaged around the joint enterprise of reading, critiquing, and understanding the research studies with the goal of improving practice. The teachers also asked each other analytical questions, which became a shared repertoire of the journal club. They reflected on their practice by presenting, reading, and discussing the articles, which helped them to determine whether and how the findings from the articles could be incorporated into their teaching practice. In doing so, they learned the skills needed to critique the research literature in

  12. Teaching Note--Incorporating Journal Clubs into Social Work Education: An Exploratory Model

    ERIC Educational Resources Information Center

    Moore, Megan; Fawley-King, Kya; Stone, Susan I.; Accomazzo, Sarah M.

    2013-01-01

    This article outlines the implementation of a journal club for master's and doctoral social work students interested in mental health practice. It defines educational journal clubs and discusses the history of journal clubs in medical education and the applicability of the model to social work education. The feasibility of implementing…

  13. Interdisciplinary Journal Club: Advancing Knowledge Translation in a Rural State

    ERIC Educational Resources Information Center

    Dennis, Ruth E.; Potvin, Marie-Christine; MacLeod, Marie

    2010-01-01

    Professionals who provide health and related supports and services to children with disabilities in educational programs and community settings must practice in an evidence-based manner to ensure children and families receive the highest quality care. Vermont's Interdisciplinary Journal Club provides a successful approach to supporting…

  14. Journal Club Format Emphasizing Techniques of Critical Reading.

    ERIC Educational Resources Information Center

    Woods, James R., Jr.; Winkel, Craig E.

    1982-01-01

    The journal club format offers the resident a unique opportunity to develop specific skills in reading, comprehending, and evaluating medical literature. A course designed for residents in obstetrics and gynecology at the Letterman Army Medical Center and at the University of Cincinnati is described. (MLW)

  15. Biology Blogs: An Online Journal Club & Assessment Tool

    ERIC Educational Resources Information Center

    De Souza-Hart, Janet A.

    2010-01-01

    A "blog" can be used as an online journal club to supplement classroom learning. When crafted in a certain way, it can help students develop their scientific reading comprehension, critical thinking, and writing skills in a way that can easily be assessed by educators.

  16. Chinese Obstetrics & Gynecology journal club: a randomised controlled trial

    PubMed Central

    Tsui, Ilene K; Dodson, William C; Kunselman, Allen R; Kuang, Hongying; Han, Feng-Juan; Legro, Richard S; Wu, Xiao-Ke

    2016-01-01

    Objectives To assess whether a journal club model could improve comprehension and written and spoken medical English in a population of Chinese medical professionals. Setting and participants The study population consisted of 52 medical professionals who were residents or postgraduate master or PhD students in the Department of Obstetrics and Gynecology, Heilongjiang University of Chinese Medicine, China. Intervention After a three-part baseline examination to assess medical English comprehension, participants were randomised to either (1) an intensive journal club treatment arm or (2) a self-study group. At the conclusion of the 8-week intervention participants (n=52) were re-tested with new questions. Outcome measures The primary outcome was the change in score on a multiple choice examination. Secondary outcomes included change in scores on written and oral examinations which were modelled on the Test of English as a Foreign Language (TOEFL). Results Both groups had improved scores on the multiple choice examination without a statistically significant difference between them (90% power). However, there was a statistically significant difference between the groups in mean improvement in scores for both written (95% CI 1.1 to 5.0; p=0.003) and spoken English (95% CI 0.06 to 3.7; p=0.04) favouring the journal club intervention. Conclusions Interacting with colleagues and an English-speaking facilitator in a journal club improved both written and spoken medical English in Chinese medical professionals. Journal clubs may be suitable for use as a self-sustainable teaching model to improve fluency in medical English in foreign medical professionals. Trial registration number NCT01844609. PMID:26823180

  17. Global emergency medicine journal club: social media responses to the January 2014 online emergency medicine journal club on subarachnoid hemorrhage.

    PubMed

    Chan, Teresa M; Rosenberg, Hans; Lin, Michelle

    2014-07-01

    From January 20 to 24, 2014, Annals continued a successful collaboration with an academic Web site, Academic Life in Emergency Medicine (ALiEM), to host another Global Emergency Medicine Journal Club session featuring the 2013 Journal of the American Medical Association article "Clinical Decision Rules to Rule Out Subarachnoid Hemorrhage for Acute Headache" by Perry et al. This online journal club used the power of rapid Twitter conversations, a live videocast with the authors, and more detailed discussions hosted on the ALiEM Web site's comment section. There were more than 1,431 individuals from 501 cities in 59 countries who viewed the blog post. During this 5-day event, 28 comments (average word count 153 words) and 206 tweets were made. This summary article details the community discussion, shared insights, and analytic data generated during this novel, multiplatform approach.

  18. ASBMB Journal Club - Office of Cancer Clinical Proteomics Research

    Cancer.gov

    On Wednesday, November 12, 2014 from 2:00 PM to 3:00 PM EST, Daniel Liebler, PhD (Vanderbilt University) and Karin Rodland, PhD (Pacific Northwestern National Laboratory) and Ruedi Aebersold, PhD (Swiss Federal Institute of Technology) will share their research insight as part of the ASBMB Journal Club.  Both Doctors Liebler and Rodland are Principal Investigators in the NCI’s Clinical Proteomic Tumor Analysis Consortium.

  19. Undergraduate Journal Club as an Intervention to Improve Student Development in Applying the Scientific Process

    ERIC Educational Resources Information Center

    Sandefur, Conner I.; Gordy, Claire

    2016-01-01

    We developed and implemented a series of workshops and seminars in an undergraduate journal club targeted at improving student development in applying the scientific process. Students were surveyed before and after participating in the club about their confidence in accessing, analyzing, and reporting scientific research. Post-club, the students…

  20. Undergraduate journal club as an intervention to improve student development in applying the scientific process

    PubMed Central

    Sandefur, Conner I; Gordy, Claire

    2016-01-01

    Active learning improves student performance in STEM courses. Exposure to active learning environments generally occurs through traditional laboratory courses and independent research, both of which require access to resources that are limited at many universities. A previously reported active learning-based undergraduate journal club improved student achievement in communicating science. Here, we expanded on this previous journal club to improve student performance in the process of science. We developed and implemented a series of workshops and seminars referred to as “CASL Club,” an undergraduate journal club targeted at improving student development in applying the scientific process. Students were surveyed before and after CASL club about their confidence in accessing, analyzing, and reporting scientific research. Post-CASL club, the students reported increases in confidence in their abilities to access and present scientific articles and write scientific abstracts. Additionally, the students reported improved confidence and performance in their courses. Compared to the previous journal club study, the majority of sampled journal club participants were not exposed to primary literature as part of their general coursework. Our results illustrate active-learning based undergraduate journal clubs as a way to expose students to primary literature and improve students’ ability to apply scientific process in an active-learning environment at resource-limited universities. PMID:27212737

  1. A journal club as a teaching and learning strategy in nurse teacher education.

    PubMed

    Sheehan, J

    1994-03-01

    An account of the operation of a journal club in a Postgraduate Certificate in Education course for teachers of nursing is reported here. The paper is based on three issues: the background to journal clubs, the process involved in the operation of the club concerned, and the expected outcomes. The origins of journal clubs and the reading habits of nurses are considered in the background section through a review of some of the relevant literature. The negotiation involved, the frequency of meetings and the ethos in which they were conducted are discussed in the section on the processes involved. In the final section, both the tangible and personal outcomes are discussed and the conclusion reached is that a journal club is a worthwhile educational activity.

  2. Globalization of Continuing Professional Development by Journal Clubs via Microblogging: A Systematic Review

    PubMed Central

    Perera, Marlon; Lawrentschuk, Nathan; Romanic, Diana; Papa, Nathan; Bolton, Damien

    2015-01-01

    Background Journal clubs are an essential tool in promoting clinical evidence-based medical education to all medical and allied health professionals. Twitter represents a public, microblogging forum that can facilitate traditional journal club requirements, while also reaching a global audience, and participation for discussion with study authors and colleagues. Objective The aim of the current study was to evaluate the current state of social media–facilitated journal clubs, specifically Twitter, as an example of continuing professional development. Methods A systematic review of literature databases (Medline, Embase, CINAHL, Web of Science, ERIC via ProQuest) was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A systematic search of Twitter, the followers of identified journal clubs, and Symplur was also performed. Demographic and monthly tweet data were extracted from Twitter and Symplur. All manuscripts related to Twitter-based journal clubs were included. Statistical analyses were performed in MS Excel and STATA. Results From a total of 469 citations, 11 manuscripts were included and referred to five Twitter-based journal clubs (#ALiEMJC, #BlueJC, #ebnjc, #urojc, #meded). A Twitter-based journal club search yielded 34 potential hashtags/accounts, of which 24 were included in the final analysis. The median duration of activity was 11.75 (interquartile range [IQR] 19.9, SD 10.9) months, with 7 now inactive. The median number of followers and participants was 374 (IQR 574) and 157 (IQR 272), respectively. An overall increasing establishment of active Twitter-based journal clubs was observed, resulting in an exponential increase in total cumulative tweets (R 2=.98), and tweets per month (R 2=.72). Cumulative tweets for specific journal clubs increased linearly, with @ADC_JC, @EBNursingBMJ, @igsjc, @iurojc, and @NephJC, and showing greatest rate of change, as well as total impressions per month since

  3. Another Time, Another Space: The Evolution of the Virtual Journal Club.

    PubMed

    Chetlen, Alison L; Dell, Carol M; Solberg, Agnieszka O; Otero, Hansel J; Burton, Kirsteen R; Heller, Matthew T; Lakomkin, Nikita; Desouches, Stephane L; Smith, Stacy E

    2017-03-01

    Virtual journal clubs (VJCs) provide a standardized, easily accessible forum for evidence-based discussion. The new virtual reality setting in which journal clubs and other online education events now take place offers great advantages and new opportunities for radiologists in academic medicine and private practice. VJCs continue to evolve, largely due to many emerging technologies and platforms. VJCs will continue to play an increasingly important role in medical education, interdisciplinary interaction, and multi-institutional collaboration. In this article, we discuss how to conduct and lead a critical review of medical literature in the setting of a virtual or traditional journal club. We discuss the current applications of VJCs in medical and graduate medical education and continued lifelong learning. We also explain the advantages and disadvantages of VJCs over traditional venues. Finally, the reader will be given the tools to successfully implement and run a VJC.

  4. Burn center journal club promotes clinical research, continuing education, and evidence-based practice.

    PubMed

    Fowler, Laura; Gottschlich, Michele M; Kagan, Richard J

    2013-01-01

    The purpose of this study was to characterize the structure, policy, implementation, and outcome measures of a burn team journal club to assess its effectiveness in promoting multidisciplinary education relative to research competency, clinical knowledge, and evidence-based practice. After 2 years of a new multidisciplinary format, an anonymous quality assurance survey was distributed to staff members of a regional pediatric burn center to evaluate the impact of the journal club on clinical and research indicators. The 24 journal club meetings evaluated in this study included a variety of topics, among which were wound healing, infection, nutrition, metabolism, sleep, medications, alternative medicine, research compliance, and child abuse. The speakers included a variety of hospital personnel: 26% researchers, 23% physicians, 20% registered nurses, and 31% other disciplines and attendance mean was 29 participants per session (range 17-50). Survey results from 30 respondents indicated that 100% judged the program to be valuable to personal educational needs and 83% indicated that format did not warrant change. According to self-report data, the journal club enhanced medical knowledge (90%), patient care (73%), research competency (70%), critical thinking (63%), and evidence-based practice (63%). Results indicate that the journal club program was well received by participants, and promoted enhanced knowledge and improved patient care. In the future, barriers to research initiatives and integration of research findings into practice warrant follow-up study. Journal club should be incorporated into the learning curriculum of burn practitioners as a means to promote critical thinking, research competency, and evidence-based clinical practice.

  5. An evidence-based journal club for dental residents in a GPR program.

    PubMed

    Grant, William D

    2005-06-01

    The journal club offers a significant opportunity to serve as both an educational experience but also as a real-world example of the application of the principles and practices of evidence-based dentistry (EBD). Designed around the American Dental Association's recommended four steps in the implementation of the EBD process, the journal clubs are held once per month for GPR residents. The structured process allows residents to formulate answerable clinical questions, track down with maximum efficiency the best evidence with which to answer the questions, critically appraise the evidence for its validity and usefulness, and apply the results of this appraisal in clinical practice as appropriate.

  6. Use of a Journal Club for Professional Development: Outcomes in a School-Based Occupational Therapy Practice

    ERIC Educational Resources Information Center

    Szucs, Kimberly A.; Benson, Jeryl D.; Corturillo, Amanda

    2016-01-01

    This article investigates the outcomes of a journal club on the evidence-based practice (EBP) skills of school-based practitioners. Participants' knowledge, attitudes, and perceptions of EBP were collected using pre- and postsurveys following 6 monthly journal club sessions. Participants identified time, availability of articles, and decreased…

  7. Using a Guided Journal Club as a Teaching Strategy to Enhance Learning Skills for Evidence-Based Practice.

    PubMed

    Szucs, Kimberly A; Benson, Jeryl D; Haneman, Brianne

    2017-02-03

    Journal clubs are used in both clinical and academic settings in order for clinicians and students to utilize current best-practices, become competent in evidence based practice and develop critical appraisal skills. Journal clubs encourage students to practice searching for relevant research, critically appraising articles, and contributing to open discussions with peers. Establishing the practice of reading and critiquing literature in the classroom can enable the creation of a habit of using current evidence when students enter practice. This article describes a strategy for delivering a structured academic journal club to support the learning of evidence based practice skills and students' perception of the journal club, including their overall satisfaction, knowledge base skills, and presentation skills. Students had an overall positive experience and perception of the guided journal club activity. From the instructor's perspective, this assignment was an excellent opportunity to engage students in learning the process of evidence based practice.

  8. ICTs as Placed Resources in a Rural Kenyan Secondary School Journalism Club

    ERIC Educational Resources Information Center

    Kendrick, Maureen; Chemjor, Walter; Early, Margaret

    2012-01-01

    In this study, we draw on three interrelated concepts, i.e. placed resources, multiliteracies and the carnivalesque, to understand how information and communication technology (ICT) resources are taken up within the context of a print-based journalism club. Our research participants attend an under-resourced girls' residential secondary school in…

  9. The Research Journal Club: Pedagogy of Research in the Preparation of Students in Educational Leadership

    ERIC Educational Resources Information Center

    Bowers, Alex J.; Murakami-Ramalho, Elizabeth

    2010-01-01

    Following calls to increase professional communities of practice around research in educational leadership graduate programs, this study describes the ongoing process of creating a research journal club. We share the process of implementation, describe the structure adopted, and the outcomes observed one year after the establishment of a journal…

  10. A Journal-Club-Based Class that Promotes Active and Cooperative Learning of Biology

    ERIC Educational Resources Information Center

    Kitazono, Ana A.

    2010-01-01

    A journal-club-based class has been developed to promote active and cooperative learning and expose seniors in biochemistry and cellular molecular biology to recent research in the field. Besides giving oral presentations, students also write three papers: one discussing an article of their own choosing and two, discussing articles presented by…

  11. Journal Clubs and Case Conferences: From Academic Tradition to Communities of Practice

    ERIC Educational Resources Information Center

    Price, David W.; Felix, Kate G.

    2008-01-01

    Introduction: As small group learning sessions, Journal Clubs (JCs) and Case Conferences (CCs), if structured interactively, have potential as educational formats that can change practice. However, the degree to which these formats, as currently typically structured, lead to practice change is unknown. Methods: We used concepts of communities of…

  12. Using Journal Clubs to Cultivate a Community of Practice at the Graduate Level

    ERIC Educational Resources Information Center

    Newswander, L. K.; Borrego, M.

    2009-01-01

    This paper discusses the benefits of a community of practice (CoP) approach to graduate education in engineering and examines guidelines for implementation. Community of practice theory and applications to practice are presented. Journal clubs, groups of faculty and students who meet regularly to discuss literature, are identified as one specific…

  13. Classroom Journal Club: Collaborative Study of Contemporary Primary Literature in the Biomechanics Classroom.

    PubMed

    Kuxhaus, Laurel; Corbiere, Nicole C

    2016-07-01

    Current engineering pedagogy primarily focuses on developing technical proficiency and problem solving skills; the peer-review process for sharing new research results is often overlooked. The use of a collaborative classroom journal club can engage students with the excitement of scientific discovery and the process of dissemination of research results, which are also important lifelong learning skills. In this work, a classroom journal club was implemented and a survey of student perceptions spanning three student cohorts was collected. In this collaborative learning activity, students regularly chose and discussed a recent biomechanics journal article, and were assessed based on specific, individual preparation tasks. Most student-chosen journal articles were relevant to topics discussed in the regular class lecture. Surveys assessed student perceptions of the activity. The survey responses show that, across all cohorts, students both enjoyed the classroom journal club and recognized it as an important learning experience. Many reported discussing their journal articles with others outside of the classroom, indicating good engagement. The results demonstrate that student engagement with primary literature can foster both technical knowledge and lifelong learning skills.

  14. Journal clubs: an educational approach to advance understanding among community partners and academic researchers about CBPR and cancer health disparities.

    PubMed

    Vadaparampil, Susan T; Simmons, Vani N; Lee, Ji-Hyun; Malo, Teri; Klasko, Lynne; Rodriguez, Maria; Waddell, Rhonda; Gwede, Clement K; Meade, Cathy D

    2014-03-01

    Journal clubs may enhance the knowledge and skills necessary to engage in community-based participatory research (CBPR) that will ultimately impact cancer health disparities. This article (1) describes an innovative approach to adapting the traditional journal club format to meet community and academic participants' needs, (2) presents evaluation data, and (3) explores whether responses differed between academic and community members. Five journal clubs occurred between February 2011 and May 2012 as a training activity of a regional cancer health disparities initiative. Each journal club was jointly planned and facilitated by an academic member in collaboration with a community partner. Attendees were recruited from academic programs across the Moffitt Cancer Center/University and community partners. Responses to a 13-item evaluation of each journal club session were compared to assess whether certain topics were evaluated more favorably, and explore differences between academic and community participants' assessment of the topic relevance. Evaluations were positive (mean ratings >4 out of 5) on most items and overall. No statistically significant differences were observed between academic and community members' ratings. Key overlapping interests by community partners and academic researchers/trainees for future journal club topics included discussing real-world CBPR examples and methods for involving the community in research. Although the initial goal was to use journal clubs as an educational tool to increase CBPR knowledge and skills of junior faculty trainees, results suggest mutual academic-community benefit and interest in learning more about CBPR as a way to reduce cancer health disparities.

  15. The Impact of a Student-Run Journal Club on Pharmacy Students' Self-Assessment of Critical Appraisal Skills.

    PubMed

    Landi, Macayla; Springer, Sydney; Estus, Erica; Ward, Kristina

    2015-06-01

    After attending an educational session on hosting journal clubs at the 2013 Annual Meeting & Exhibition, American Society of Consultant Pharmacists, Seattle, Washington, two third-year professional pharmacy students created a student-run journal club through the University of Rhode Island's ASCP student chapter. Three journal club sessions were held during the spring semester and were open to all pharmacy students. Students completed an anonymous pre- and post-survey to assess confidence in evaluating medical literature. Of the 18 participants, 5 were lost to follow-up. Significant improvements were found among all participants in their confidence in critically evaluating clinical research, interpreting statistical methods, and completing a journal club during Advanced Pharmacy Practice Experience rotations. This activity can be replicated in academic settings as well as workplace environments where pharmacy students are involved.

  16. How to establish an interactive eConference and eJournal Club.

    PubMed

    Yang, Paul R; Meals, Roy A

    2014-01-01

    With our hand team scattered across several different locations, it is difficult to find a time to get together for our weekly didactic hand conference and monthly hand journal club. In addition, traffic and tight clinical schedules sometimes force conferences to start late or be canceled. Our solution was to set up an on-line conference. Using TeamViewer to host our conference and Skype to host our journal clubs, we experienced increased attendance by both faculty and residents in our meetings. In this article, we establish a method of hosting effective on-line videoconferences to facilitate nearly universal participation of our hand team, and we hope to assist others who wish to establish similar setups in their communities.

  17. ‘Research clinics’: online journal clubs between south and north for student mentoring

    PubMed Central

    Atkins, Salla; Varshney, Dinansha; Meragia, Elnta; Zwarenstein, Merrick; Diwan, Vishal

    2016-01-01

    Background Capacity development in health research is high on the agenda of many low- and middle-income countries. Objective The ARCADE projects, funded by the EU, have been working in Africa and Asia since 2011 in order to build postgraduate students’ health research capacity. In this short communication, we describe one initiative in these projects, that of research clinics – online journal clubs connecting southern and northern students and experts. Design We describe the implementation of these research clinics together with student and participant experiences. Results From 2012 to 2015, a total of seven journal clubs were presented by students and junior researchers on topics related to global health. Sessions were connected through web conferencing, connecting experts and students from different countries. Conclusions The research clinics succeeded in engaging young researchers across the globe and connecting them with global experts. The contacts and suggestions made were appreciated by students. This format has potential to contribute toward research capacity building in low- and middle-income countries. PMID:27725079

  18. Role of Evidence-Based Reviews in Surgery in teaching critical appraisal skills and in journal clubs

    PubMed Central

    Ahmadi, Negar; Dubois, Luc; McKenzie, Marg; Brown, Carl J.; MacLean, Anthony R.; McLeod, Robin S.

    2013-01-01

    Background Evidence-Based Reviews in Surgery (EBRS) is a program developed to teach critical appraisal skills to general surgeons and residents. The purpose of this study was to assess the use of EBRS by general surgery residents across Canada and to assess residents’ opinions regarding EBRS and journal clubs. Methods We surveyed postgraduate year 2–5 residents from 15 general surgery programs. Data are presented as percentages and means. Results A total of 231 residents (58%, mean 56% per program, range 0%–100%) responded: 172 (75%) residents indicated that they know about EBRS and that it is used in their programs. More than 75% of residents who use EBRS agreed or strongly agreed that the EBRS clinical and methodological articles and reviews are relevant. Only 55 residents (24%) indicated that they used EBRS online. Most residents (198 [86%]) attend journal clubs. The most common format is a mandatory meeting held at a special time every month with faculty members with epidemiological and clinical expertise. Residents stated that EBRS articles were used exclusively (13%) or in conjunction with other articles (57%) in their journal clubs. Most respondents (176 of 193 [91%]) stated that journal clubs are very or somewhat valuable to their education. Conclusion The EBRS program is widely used among general surgery residents across Canada. Although most residents who use EBRS rate it highly, a large proportion are unaware of EBRS online features. Thus, future efforts to increase awareness of EBRS online features and increase its accessibility are required. PMID:23883511

  19. Taking Journal Clubs off Autopilot: A Case Study of Teaching Literature Evaluation Skills to Preclinical MD/PhD Students.

    PubMed

    Currier, Rebecca L; Schneider, Marguerite Reid; Heubi, James E

    2013-12-01

    Researchers designed learner-directed journal clubs to develop literature evaluation skills in preclinical students. Sessions balanced student-led discussion with structured objectives and faculty support. During the pilot with preclinical MD/PhD students, self-rated mastery improved over all 17 measured objectives. Six exercises have since been incorporated into the full medical school curriculum.

  20. A Journal Club Workshop that Teaches Undergraduates a Systematic Method for Reading, Interpreting, and Presenting Primary Literature

    ERIC Educational Resources Information Center

    Robertson, Katherine

    2012-01-01

    For success after graduation, science undergraduates must master a number of skills such as scientific literacy (interpretation and evaluation of primary research articles) and effective communication. Many researchers have recognized the benefits of journal clubs in developing such skills, and a large body of literature describes how they may be…

  1. Using architectures for semantic interoperability to create journal clubs for emergency response

    SciTech Connect

    Powell, James E; Collins, Linn M; Martinez, Mark L B

    2009-01-01

    In certain types of 'slow burn' emergencies, careful accumulation and evaluation of information can offer a crucial advantage. The SARS outbreak in the first decade of the 21st century was such an event, and ad hoc journal clubs played a critical role in assisting scientific and technical responders in identifying and developing various strategies for halting what could have become a dangerous pandemic. This research-in-progress paper describes a process for leveraging emerging semantic web and digital library architectures and standards to (1) create a focused collection of bibliographic metadata, (2) extract semantic information, (3) convert it to the Resource Description Framework /Extensible Markup Language (RDF/XML), and (4) integrate it so that scientific and technical responders can share and explore critical information in the collections.

  2. Journal Club presentation in research orientation at Bahria University Medical & Dental College

    PubMed Central

    Rehman, Rehana; Rehan, Rabiya; Usmani, Ambreen

    2015-01-01

    Objective: To determine faculty perception on journal club (JC) presentation at Bahria University Medical and Dental College (BUMDC), Karachi. Pakistan. Methods: It was a cross sectional study conducted from January 2009 to December 2012 to acquire faculty member’s feedback on JC presentations in structured meeting at BUMDC. Feedback was acquired by a self-reported questionnaire on a 3-pt Likert scale with a score of 1= disagree, 2= neutral, 3 = agree. Respondents were divided into Group I; senior faculty (professors, associates and assistants) and Group II of junior faculty (lecturers). Chi square test was applied to compare categorical variables; results considered significant with p value< 0.05. Result: A total of 75JC presentations were made in study period. In Group I, response was acquired by 5 Professors, 3 Associate Professors and 7 Assistant Professors whereas 34 lecturers comprised of Group II. Both groups responded to usefulness of JC equally without any significant difference. JC encouraged literature search in 35(72%), enabled 38(78%) to recall their knowledge and 34(70%) to understand study objectives. The participants 34(70%) were able to comprehend research methodology, 19(38%) understood biostatistics and 29(59%) evaluated the paper critically. The exercise motivated 36(74%) and 30(62%) participants were able to design their research projects. Conclusions: Orientation of research at BUMDC was made possible by JC discussions which encouraged literature review from reputable journals, understanding of research methodology and critical appraisals that facilitated formulation of research plans. PMID:25878630

  3. The use of a virtual learning environment in promoting virtual journal clubs and case-based discussions in trauma and orthopaedic postgraduate medical education: the Leicester experience.

    PubMed

    Palan, J; Roberts, V; Bloch, B; Kulkarni, A; Bhowal, B; Dias, J

    2012-09-01

    The use of journal clubs and, more recently, case-based discussions in order to stimulate debate among orthopaedic surgeons lies at the heart of orthopaedic training and education. A virtual learning environment can be used as a platform to host virtual journal clubs and case-based discussions. This has many advantages in the current climate of constrained time and diminishing trainee and consultant participation in such activities. The virtual environment model opens up participation and improves access to journal clubs and case-based discussions, provides reusable educational content, establishes an electronic record of participation for individuals, makes use of multimedia material (including clinical imaging and photographs) for discussion, and finally, allows participants to link case-based discussions with relevant papers in the journal club. The Leicester experience highlights the many advantages and some of the potential difficulties in setting up such a virtual system and provides useful guidance for those considering such a system in their own training programme. As a result of the virtual learning environment, trainee participation has increased and there is a trend for increased consultant input in the virtual journal club and case-based discussions. It is likely that the use of virtual environments will expand to encompass newer technological approaches to personal learning and professional development.

  4. Evidence-based Medicine versus the Conventional Approach to Journal Club Sessions: Which One Is More Successful in Teaching Critical Appraisal Skills?

    PubMed

    Alavi-Moghaddam, Mostafa; Yazdani, Shahram; Mortazavi, Fathie; Chichi, Samira; Hosseini-Zijoud, Seyed-Mostafa

    2016-05-01

    This study aimed to compare evidence-based medicine (EBM) vs. conventional approaches to journal club sessions in teaching critical appraisal skills in reading papers by emergency medicine residents. This double cut off discontinuation regression quasi-experimental study was conducted among emergency medicine residents. EBM vs. the conventional approach were applied to teach critical appraisal skills for half of the residents as an experimental group and another half as a control group respectively. Both groups participated in one hour monthly journal club sessions for six months. Before and after the study, all participants were examined by two tests: the Fresno Test (FT) [to evaluate their knowledge about EBM] and the Critical Appraisal Skills Test (CAST) [to evaluate their competency with critical appraisal skills]. The allocation of the participants into the experimental or control groups was according to their CAST scores before the study. 50 emergency medicine residents participated. After the study, the scores of both groups in the FT and CAST significantly improved (p<0.01), and the promotion of scores of the FT and CAST in the experimental group were more than that of the conventional group (p<0.0001). The current study indicated that an evidence-based medicine approach in journal club sessions was comparatively more advantageous compared to the conventional approach in teaching critical appraisal skills for reading papers among the residents of emergency medicine.

  5. JGME-ALiEM Hot Topics in Medical Education Online Journal Club: An Analysis of a Virtual Discussion About Resident Teachers

    PubMed Central

    Sherbino, Jonathan; Joshi, Nikita; Lin, Michelle

    2015-01-01

    Background  In health professionals' education, senior learners play a key role in the teaching of junior colleagues. Objective  We describe an online discussion about residents as teachers to highlight the topic and the online journal club medium. Methods  In January 2015, the Journal of Graduate Medical Education (JGME) and the Academic Life in Emergency Medicine blog facilitated an open-access, online, weeklong journal club on the JGME article “What Makes a Great Resident Teacher? A Multicenter Survey of Medical Students Attending an Internal Medicine Conference.” Social media platforms used to promote asynchronous discussions included a blog, a video discussion via Google Hangouts on Air, and Twitter. We performed a thematic analysis of the discussion. Web analytics were captured as a measure of impact. Results  The blog post garnered 1324 page views from 372 cities in 42 countries. Twitter was used to endorse discussion points, while blog comments provided opinions or responded to an issue. The discussion focused on why resident feedback was devalued by medical students. Proposed explanations included feedback not being labeled as such, the process of giving delivery, the source of feedback, discrepancies with self-assessment, and threats to medical student self-image. The blog post resulted in a crowd-sourced repository of resident teacher resources. Conclusions  An online journal club provides a novel discussion forum across multiple social media platforms to engage authors, content experts, and the education community. Crowd-sourced analysis of the resident teacher role suggests that resident feedback to medical students is important, and barriers to student acceptance of feedback can be overcome. PMID:26457152

  6. Does journal club membership improve research evidence uptake in different allied health disciplines: a pre-post study

    PubMed Central

    2012-01-01

    Background Although allied health is considered to be one 'unit' of healthcare providers, it comprises a range of disciplines which have different training and ways of thinking, and different tasks and methods of patient care. Very few empirical studies on evidence-based practice (EBP) have directly compared allied health professionals. The objective of this study was to examine the impact of a structured model of journal club (JC), known as iCAHE (International Centre for Allied Health Evidence) JC, on the EBP knowledge, skills and behaviour of the different allied health disciplines. Methods A pilot, pre-post study design using maximum variation sampling was undertaken. Recruitment was conducted in groups and practitioners such as physiotherapists, occupational therapists, speech pathologists, social workers, psychologists, nutritionists/dieticians and podiatrists were invited to participate. All participating groups received the iCAHE JC for six months. Quantitative data using the Adapted Fresno Test (McCluskey & Bishop) and Evidence-based Practice Questionnaire (Upton & Upton) were collected prior to the implementation of the JC, with follow-up measurements six months later. Mean percentage change and confidence intervals were calculated to compare baseline and post JC scores for all outcome measures. Results The results of this study demonstrate variability in EBP outcomes across disciplines after receiving the iCAHE JC. Only physiotherapists showed statistically significant improvements in all outcomes; speech pathologists and occupational therapists demonstrated a statistically significant increase in knowledge but not for attitude and evidence uptake; social workers and dieticians/nutritionists showed statistically significant positive changes in their knowledge, and evidence uptake but not for attitude. Conclusions There is evidence to suggest that a JC such as the iCAHE model is an effective method for improving the EBP knowledge and skills of allied

  7. Rich-club and page-club coefficients for directed graphs

    NASA Astrophysics Data System (ADS)

    Smilkov, Daniel; Kocarev, Ljupco

    2010-06-01

    Rich-club and page-club coefficients and their null models are introduced for directed graphs. Null models allow for a quantitative discussion of the rich-club and page-club phenomena. These coefficients are computed for four directed real-world networks: Arxiv High Energy Physics paper citation network, Web network (released from Google), Citation network among US Patents, and email network from a EU research institution. The results show a high correlation between rich-club and page-club ordering. For journal paper citation network, we identify both rich-club and page-club ordering, showing that “elite” papers are cited by other “elite” papers. Google web network shows partial rich-club and page-club ordering up to some point and then a narrow declining of the corresponding normalized coefficients, indicating the lack of rich-club ordering and the lack of page-club ordering, i.e. high in-degree (PageRank) pages purposely avoid sharing links with other high in-degree (PageRank) pages. For UC patents citation network, we identify page-club and rich-club ordering providing a conclusion that “elite” patents are cited by other “elite” patents. Finally, for email communication network we show lack of both rich-club and page-club ordering. We construct an example of synthetic network showing page-club ordering and the lack of rich-club ordering.

  8. Development of an ACP facility

    SciTech Connect

    Gil-Sung You; Won-Myung Choung; Jeong-Hoe Ku; il-Je Cho; Dong-Hak Kook; Kie-Chan Kwon; Eun-Pyo Lee; Ji-Sup Yoon; Seong-Won Park; Won-Kyung Lee

    2007-07-01

    KAERI has been developing an advanced spent fuel conditioning process (ACP). The ACP facility for a process demonstration consists of two air-sealed type hot cells. The safety analysis results showed that the facility was designed safely. The relevant integrated performance tests were also carried out successfully. (authors)

  9. Journaling.

    ERIC Educational Resources Information Center

    Barlow, Bob

    2001-01-01

    Daily journal writing can help students become strong, confident writers. Students can use journals to reflect on what they are studying, brainstorm on a topic before writing an essay, track and react to current events, and explore ideas in their imaginations. Tips for journal writing include: keep it stress free, reassure students they are…

  10. What do evidence-based secondary journals tell us about the publication of clinically important articles in primary healthcare journals?

    PubMed Central

    McKibbon, Kathleen Ann; Wilczynski, Nancy L; Haynes, Robert Brian

    2004-01-01

    Background We conducted this analysis to determine i) which journals publish high-quality, clinically relevant studies in internal medicine, general/family practice, general practice nursing, and mental health; and ii) the proportion of clinically relevant articles in each journal. Methods We performed an analytic survey of a hand search of 170 general medicine, general healthcare, and specialty journals for 2000. Research staff assessed individual articles by using explicit criteria for scientific merit for healthcare application. Practitioners assessed the clinical importance of these articles. Outcome measures were the number of high-quality, clinically relevant studies published in the 170 journal titles and how many of these were published in each of four discipline-specific, secondary "evidence-based" journals (ACP Journal Club for internal medicine and its subspecialties; Evidence-Based Medicine for general/family practice; Evidence-Based Nursing for general practice nursing; and Evidence-Based Mental Health for all aspects of mental health). Original studies and review articles were classified for purpose: therapy and prevention, screening and diagnosis, prognosis, etiology and harm, economics and cost, clinical prediction guides, and qualitative studies. Results We evaluated 60,352 articles from 170 journal titles. The pass criteria of high-quality methods and clinically relevant material were met by 3059 original articles and 1073 review articles. For ACP Journal Club (internal medicine), four titles supplied 56.5% of the articles and 27 titles supplied the other 43.5%. For Evidence-Based Medicine (general/family practice), five titles supplied 50.7% of the articles and 40 titles supplied the remaining 49.3%. For Evidence-Based Nursing (general practice nursing), seven titles supplied 51.0% of the articles and 34 additional titles supplied 49.0%. For Evidence-Based Mental Health (mental health), nine titles supplied 53.2% of the articles and 34 additional

  11. Exploring the perspectives of allied health practitioners toward the use of journal clubs as a medium for promoting evidence-based practice: a qualitative study

    PubMed Central

    2011-01-01

    Background Research evidence suggests that journal clubs (JCs) are one approach which can be used to bridge the gap between research and clinical practice. However, there are issues which potentially threaten their viability such as on-going participation or compliance with attendance, which require further exploration. The objectives of this study are: to explore the views and perspectives of allied health practitioners (AHPs) regarding the use of any type of JC in promoting evidence-based practice (EBP); to identify ways in which an innovative model of JC developed by the International Centre for Allied Health Evidence (iCAHE) might be refined. Methods A qualitative descriptive study utilising focus group interviews with various groups of AHP was undertaken-- those who have been exposed to the iCAHE JC model and those who have no experience of the iCAHE model (although they may have had exposure to other forms of JC). Maximum variation sampling was used to recruit participants for the study. Transcripts of focus groups were coded and distilled into content-related categories. Results Six focus groups with 39 AHPs were facilitated. Allied health practitioners perspectives' on JCs were classified in five broad categories: utility and benefits of a JC, elements of an effective and sustainable JC, barriers to participation, incentives for participation, and opportunities for improvement in the current iCAHE JC model. Overall, JCs were seen as a forum for reflective practice and keeping up-to-date with research evidence, and a venue for learning the processes involved in critical appraisal. Limited knowledge of statistics and heavy clinical workload were reported as barriers to participation in a JC. Strategies such as mentoring, strong support from managers, and providing CPD (continuing professional development) points can potentially address these barriers. Opportunities for refinement of the current iCAHE model were raised. Conclusions This study suggests that a

  12. Managing Collegiate Sport Clubs.

    ERIC Educational Resources Information Center

    Matthews, David O., Ed.

    This book is written for the administrators of college sport clubs. It is comprised of a collection of articles on the topics of: (1) Sport Club Administration and Organization; (2) Student Development through Sport Clubs; (3) Sport Club Financing and Fund-Raising; (4) Liability Concerns of Sport Clubs; and (5) Sport Club Program Surveys.…

  13. [Club drugs].

    PubMed

    Guerreiro, Diogo Frasquilho; Carmo, Ana Lisa; da Silva, Joaquim Alves; Navarro, Rita; Góis, Carlos

    2011-01-01

    Club drugs are the following substances: Methylenedioxymethamphetamine (MDMA); Methamphetamine; Lysergic Acid Diethylamide (LSD); Ketamine; Gamma-hydroxybutyrate (GHB) and Flunitrazepam. These substances are mainly used by adolescents and young adults, mostly in recreational settings like dance clubs and rave parties. These drugs have diverse psychotropic effects, are associated with several degrees of toxicity, dependence and long term adverse effects. Some have been used for several decades, while others are relatively recent substances of abuse. They have distinct pharmacodynamic and pharmacokinetic properties, are not easy to detect and, many times, the use of club drugs is under diagnosed. Although the use of these drugs is increasingly common, few health professionals feel comfortable with the diagnosis and treatment. The authors performed a systematic literature review, with the goal of synthesising the existing knowledge about club drugs, namely epidemiology, mechanism of action, detection, adverse reactions and treatment. The purpose of this article is creating in Portuguese language a knowledge data base on club drugs, that health professionals of various specialties can use as a reference when dealing with individual with this kind of drug abuse.

  14. Modified acyl-ACP desaturase

    DOEpatents

    Cahoon, E.B.; Shanklin, J.; Lindgvist, Y.; Schneider, G.

    1998-01-06

    Disclosed is a method for modifying the chain length and double bond positional specificities of a soluble plant fatty acid desaturase. More specifically, the method involves modifying amino acid contact residues in the substrate binding channel of the soluble fatty acid desaturase which contact the fatty acid. Specifically disclosed is the modification of an acyl-ACP desaturase. Amino acid contact residues which lie within the substrate binding channel are identified, and subsequently replaced with different residues to effect the modification of activity. 1 fig.

  15. Star Clubbing

    ERIC Educational Resources Information Center

    Hogan, Maria; Davis, Sarah

    2011-01-01

    Despite the rewards, there are numerous barriers to teachers running clubs: (1) getting weekly fresh activity ideas and resourcing them; (2) the lack of a budget; and (3) shortage of time. With the best will in the world, it is easy to feel that time is already swallowed up with planning and assessment of normal lessons, let alone putting in the…

  16. 26 CFR 1.401(m)-2 - ACP test.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 5 2013-04-01 2013-04-01 false ACP test. 1.401(m)-2 Section 1.401(m)-2 Internal... TAXES (CONTINUED) Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.401(m)-2 ACP test. (a) Actual contribution percentage (ACP) test—(1) In general—(i) ACP test formula. A plan satisfies the ACP test for...

  17. Boys & Girls Clubs of America

    MedlinePlus

    ... Near You. Find a Club Clubs Change Lives. Boys & Girls Clubs help millions of kids and teens ... data More About Our Impact Celebrate in April! Boys & Girls Clubs will join the military community in ...

  18. European National Society Cardiovascular Journals: Background, rationale and mission statement of the 'Editors' Club' (Task Force of the European Society of Cardiology).

    PubMed

    Alfonso, F; Ambrosio, G; Pinto, F J; van der Wall, E E

    2008-06-01

    Anesti Kondili MD, Djamaleddine Nibouche MD, Karlen Adamyan MD, Kurt Huber MD, Hugo Ector MD, Izet Masic MD, Rumiana Tarnovska MD, Mario Ivanusa MD, Vladimír Stane k MD, Jørgen Videbaek MD, Mohamed Hamed MD, Alexandras Laucevicius MD, Pirjo Mustonen MD, Jean-Yves Artigou MD, Ariel Cohen MD, Mamanti Rogava MD, Michael Böhm MD, Eckart Fleck MD, Gerd Heusch MD, Rainer Klawki MD, Panos Vardas MD, Christodoulos Stefanadis MD, József Tenczer MD, Massimo Chiariello MD, Aleksandras Laucevicius MD, Joseph Elias MD, Halima Benjelloun MD, Olaf Rødevand MD, Piotr Kul/akowski MD, Edvard Apetrei MD, Victor A. Lusov MD, Rafael G. Oganov MD, Velibor Obradovic MD, Gabriel Kamensky MD, Miran F. Kenda MD, Christer Höglund MD, Thomas F. Lüscher MD, René Lerch MD, Moufid Jokhadar MD, Habib Haouala MD, Vedat Sansoy MD, Valentin Shumakov MD, Adam Timmis MD. (European National Society Cardiovascular Journals Editors, see Appendix for complete affiliations).

  19. 7 CFR 701.44 - Agricultural Conservation Program (ACP) contracts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 7 2013-01-01 2013-01-01 false Agricultural Conservation Program (ACP) contracts. 701... AGENCY, DEPARTMENT OF AGRICULTURE AGRICULTURAL CONSERVATION PROGRAM EMERGENCY CONSERVATION PROGRAM... General § 701.44 Agricultural Conservation Program (ACP) contracts. Contracts for ACP that are, or...

  20. 7 CFR 701.44 - Agricultural Conservation Program (ACP) contracts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 7 2011-01-01 2011-01-01 false Agricultural Conservation Program (ACP) contracts. 701... AGENCY, DEPARTMENT OF AGRICULTURE AGRICULTURAL CONSERVATION PROGRAM EMERGENCY CONSERVATION PROGRAM... General § 701.44 Agricultural Conservation Program (ACP) contracts. Contracts for ACP that are, or...

  1. 7 CFR 701.44 - Agricultural Conservation Program (ACP) contracts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 7 2012-01-01 2012-01-01 false Agricultural Conservation Program (ACP) contracts. 701... AGENCY, DEPARTMENT OF AGRICULTURE AGRICULTURAL CONSERVATION PROGRAM EMERGENCY CONSERVATION PROGRAM... General § 701.44 Agricultural Conservation Program (ACP) contracts. Contracts for ACP that are, or...

  2. 7 CFR 701.44 - Agricultural Conservation Program (ACP) contracts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 7 2014-01-01 2014-01-01 false Agricultural Conservation Program (ACP) contracts. 701... AGENCY, DEPARTMENT OF AGRICULTURE AGRICULTURAL CONSERVATION PROGRAM EMERGENCY CONSERVATION PROGRAM... General § 701.44 Agricultural Conservation Program (ACP) contracts. Contracts for ACP that are, or...

  3. The Book Club Exploded

    ERIC Educational Resources Information Center

    Hoffert, Barbara

    2006-01-01

    One leader, 12 readers, and a few well-thumbed copies of Jane Austen's "Pride and Prejudice." That is all a book club once required, but this is no longer the case. This article describes how the runaway popularity of book clubs has brought with it a whole new set of possibilities. Thematic discussion? A fiction/nonfiction mix? Videoconferencing?…

  4. Multimodal Learning Clubs

    ERIC Educational Resources Information Center

    Casey, Heather

    2012-01-01

    Multimodal learning clubs link principles of motivation and engagement with 21st century technological tools and texts to support content area learning. The author describes how a sixth grade health teacher and his class incorporated multimodal learning clubs into a unit of study on human body systems. The students worked collaboratively online…

  5. 26 CFR 1.401(m)-2 - ACP test.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 5 2011-04-01 2011-04-01 false ACP test. 1.401(m)-2 Section 1.401(m)-2 Internal... TAXES (CONTINUED) Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.401(m)-2 ACP test. (a) Actual... under paragraph (a)(1) of this section either— (A) Pursuant to section 401(m)(5)(C), the ACP test...

  6. Club Drug Use

    MedlinePlus

    ... different from other illicit drugs?What are the dangers of taking club drugs?What can I do ... Drug Use | Gamma-Hydroxybutyrate (GHB)Learn about the dangers of taking gamma-hydroxybutyrate (GHB), an illegal drug ...

  7. Shewanella oneidensis FabB: A β-ketoacyl-ACP Synthase That Works with C16:1-ACP.

    PubMed

    Luo, Qixia; Li, Meng; Fu, Huihui; Meng, Qiu; Gao, Haichun

    2016-01-01

    It is established that Escherichia coli β-ketoacyl-ACP synthase (KAS) I (encoded by EcfabB) is the primary, if not exclusive, factor for elongation of the cis-3-decenoyl-ACP (C10:1-ACP) but not effective with C16:1- or longer-chain-ACPs. To test the extent to which these features apply to KAS I proteins in other species, in this study, we examined the physiological role of FabB in Shewanella oneidensis, an excellent model for researching type II fatty acid synthetic (FAS) system and its regulation. We showed that the loss of either FabA (the enzyme that introduces double bond) or FabB, in the absence of DesA which desaturizes C16 and C18 to generate respective C16:1 and C18:1, leads to a UFA auxotroph. However, fatty acid profiles of membrane phospholipid of the fabA and fabB mutants are significantly different, suggesting that FabB participates in steps beyond elongation of C10:1-ACP. Further analyses demonstrated that S. oneidensis FabB differs from EcFabB in that (i) it is not the only enzyme capable of catalyzing elongation of the cis-3-decenoyl-ACP produced by FabA, (ii) it plays a critical role in elongation of C16:1- and longer-chain-ACPs, and (iii) its overproduction is detrimental.

  8. Boys & Girls Clubs of America

    MedlinePlus

    ... Cause Donate Now Retailers Team Up to Support Boys & Girls Clubs of America During Holiday Season Sixteen ... back to nation’s leading advocate for youth MORE» Boys & Girls Clubs of America and the UPS Foundation ...

  9. The ACP (Advanced Computer Program) Branch bus and real-time applications of the ACP multiprocessor system

    SciTech Connect

    Hance, R.; Areti, H.; Atac, R.; Biel, J.; Cook, A.; Fischler, M.; Gaines, I.; Husby, D.; Nash, T.; Zmuda, T.

    1987-05-08

    The ACP Branchbus, a high speed differential bus for data movement in multiprocessing and data acquisition environments, is described. This bus was designed as the central bus in the ACP multiprocessing system. In its full implementation with 16 branches and a bus switch, it will handle data rates of 160 MByte/sec and allow reliable data transmission over inter rack distances. We also summarize applications of the ACP system in experimental data acquisition, triggering and monitoring, with special attention paid to FASTBUS environments.

  10. The Interactions of CPP–ACP with Saliva

    PubMed Central

    Huq, Noorjahan Laila; Myroforidis, Helen; Cross, Keith J.; Stanton, David P.; Veith, Paul D.; Ward, Brent R.; Reynolds, Eric C.

    2016-01-01

    The repair of early dental caries lesions has been demonstrated by the application of the remineralisation technology based on casein phosphopeptide-stabilised amorphous calcium phosphate complexes (CPP–ACP). These complexes consist of an amorphous calcium phosphate mineral phase stabilised and encapsulated by the self-assembly of milk-derived phosphopeptides. During topical application of CPP–ACP complexes in the oral cavity, the CPP encounters the enamel pellicle consisting of salivary proteins and peptides. However the interactions of the CPP with the enamel salivary pellicle are not known. The studies presented here reveal that the predominant peptides of CPP–ACP complexes do interact with specific salivary proteins and peptides of the enamel pellicle, and provide a mechanism by which the CPP–ACP complexes are localised at the tooth surface to promote remineralisation. PMID:27294918

  11. Preparation, characterization and cytocompatibility of porous ACP/PLLA composites.

    PubMed

    Gao, Yanbo; Weng, Wenjian; Cheng, Kui; Du, Piyi; Shen, Ge; Han, Gaorong; Guan, Binggang; Yan, Weiqi

    2006-10-01

    The purpose of this work was to incorporate amorphous calcium phosphate (ACP) into porous poly(L-lactic acid) (PLLA), because ACP is capable of fast phase transformation and morphological change in body fluid, such, a desired pore wall surface within bone tissue engineering scaffolds can be created. A highly porous ACP/PLLA composite was prepared by a thermally induced phase separation technique. The results showed that the composite had an interconnected pore structure with 100 mum macropores and 10 mum micropores, and 91% porosity; 40 nm primary particles of ACP were agglomerated to 3 mum aggregates, and the aggregates were homogeneously distributed in pore walls; These aggregates showed to be in situ transformed into bone-like apatite after 1 h soaking in phosphate buffered saline solution. Human osteoblast-like cell culture showed that the ACP/PLLA composite had better cell adhesion and alkaline phosphotase activity than pure PLLA. This study demonstrates that the ACP/PLLA composite can enhance cytocompatibility and could act as a promising scaffold for bone tissue engineering.

  12. The Other Club Scene

    ERIC Educational Resources Information Center

    Davis, Noah

    2007-01-01

    At colleges nationwide, students from diverse racial, cultural and socioeconomic backgrounds meet and befriend each other under the auspices of club sports. Adam Pruett, the recreational sports coordinator at the University of California, Los Angeles, says any cultural uneasiness is overcome by the students' shared passion for the particular…

  13. The Kindergarten Club.

    ERIC Educational Resources Information Center

    Palmore, Elaine Mitchell

    1999-01-01

    Describes the development of an after-school club for kindergarten-age children enrolled in a Montessori preschool program in Nashville, Tennessee. Activity units included performing a play of Sendak's "Where the Wild Things Are," studying country music and writing songs, and holding a dinner for the children's parents. (KB)

  14. Level up Book Club

    ERIC Educational Resources Information Center

    LaGarde, Jennifer; Winner, Matthew C.

    2012-01-01

    Like all great ideas, Level Up Book Club grew out of a genuine need, the spontaneous firing of a few brain sparks, and the kind of luck that comes from being "in the right place at the right time." By mid-June 2011 the authors were already "bona fide" wonder twins--two educators who, although they'd never met, had stumbled upon each other through…

  15. Memory Golf Clubs

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Memory Corporation's investigation of shape memory effect, stemming from Marshall Space Flight Center contracts to study materials for the space station, has aided in the development of Zeemet, a proprietary, high-damping shape memory alloy for the golf industry. The Nicklaus Golf Company has created a new line of golf clubs using Zeemet inserts. Its superelastic and high damping attributes translate into more spin on the ball, greater control, and a solid feel.

  16. Evolution of acyl-ACP-thioesterases and β-ketoacyl-ACP-synthases revealed by protein-protein interactions

    PubMed Central

    Beld, Joris; Blatti, Jillian L.; Behnke, Craig; Mendez, Michael; Burkart, Michael D.

    2014-01-01

    The fatty acid synthase (FAS) is a conserved primary metabolic enzyme complex capable of tolerating cross-species engineering of domains for the development of modified and overproduced fatty acids. In eukaryotes, acyl-acyl carrier protein thioesterases (TEs) off-load mature cargo from the acyl carrier protein (ACP), and plants have developed TEs for short/medium-chain fatty acids. We showed that engineering plant TEs into the green microalga Chlamydomonas reinhardtii does not result in the predicted shift in fatty acid profile. Since fatty acid biosynthesis relies on substrate recognition and protein-protein interactions between the ACP and its partner enzymes, we hypothesized that plant TEs and algal ACP do not functionally interact. Phylogenetic analysis revealed major evolutionary differences between FAS enzymes, including TEs and ketoacyl synthases (KSs), in which the former is present only in some species, whereas the latter is present in all, and has a common ancestor. In line with these results, TEs appeared to be selective towards their ACP partners whereas KSs showed promiscuous behavior across bacterial, plant and algal species. Based on phylogenetic analyses, in silico docking, in vitro mechanistic crosslinking and in vivo algal engineering, we propose that phylogeny can predict effective interactions between ACPs and partner enzymes. PMID:25110394

  17. Palmitoyl-acyl carrier protein (ACP) thioesterase and the evolutionary origin of plant acyl-ACP thioesterases.

    PubMed Central

    Jones, A; Davies, H M; Voelker, T A

    1995-01-01

    Acyl-acyl carrier protein (ACP) thioesterases play an essential role in chain termination during de novo fatty acid synthesis and in the channeling of carbon flux between the two lipid biosynthesis pathways in plants. We have discovered that there are two distinct but related thioesterase gene classes in higher plants, termed FatA and FatB, whose evolutionary divergence appears to be ancient. FatA encodes the already described 18:1-ACP thioesterase. In contrast, FatB representatives encode thioesterases preferring acyl-ACPs having saturated acyl groups. We unexpectedly obtained a 16:0-ACP thioesterase cDNA from Cuphea hookeriana seed, which accumulate predominantly 8:0 and 10:0. The 16:0 thioesterase transcripts were found in non-seed tissues, and expression in transgenic Brassica napus led to the production of a 16:0-rich oil. We present evidence that this type of FatB gene is ancient and ubiquitous in plants and that specialized plant medium-chain thioesterases have evolved independently from such enzymes several times during angiosperm evolution. Also, the ubiquitous 18:1-ACP thioesterase appears to be a derivative of a 16:0 thioesterase. PMID:7734968

  18. Clubbing of the fingers or toes

    MedlinePlus

    ... Clubbing Images Clubbing Clubbed fingers References Davis JL, Murray JF. History and physical examinations. In: Broaddus VC, Mason RJ, Ernst MD, et al. Murray & Nadel's Textbook of Respiratory Medicine . 6th ed. Philadelphia, ...

  19. Methamphetamine Use in Club Subcultures

    PubMed Central

    Kelly, Brian C.; LeClair, Amy; Parsons, Jeffrey T.

    2014-01-01

    In recent decades, methamphetamine developed a peculiar geographic distribution in the United States, with limited diffusion in the Northeast. While use within gay clubs received attention, methamphetamine in club subcultures more broadly remains less clear. Using quantitative and qualitative data, we provide a descriptive assessment of methamphetamine use in club subcultures. Methamphetamine use in club subcultures often has instrumental purposes. The context of initiation into methamphetamine use and its close connection to cocaine shape later patterns of use. Viewing meth solely as a gay party drug misses a significant part of the population and may misguide public health strategies to reduce methamphetamine use in the Northeast. PMID:23848380

  20. Acalabrutinib (ACP-196): a selective second-generation BTK inhibitor.

    PubMed

    Wu, Jingjing; Zhang, Mingzhi; Liu, Delong

    2016-03-09

    More and more targeted agents become available for B cell malignancies with increasing precision and potency. The first-in-class Bruton's tyrosine kinase (BTK) inhibitor, ibrutinib, has been in clinical use for the treatment of chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's macroglobulinemia. More selective BTK inhibitors (ACP-196, ONO/GS-4059, BGB-3111, CC-292) are being explored. Acalabrutinib (ACP-196) is a novel irreversible second-generation BTK inhibitor that was shown to be more potent and selective than ibrutinib. This review summarized the preclinical research and clinical data of acalabrutinib.

  1. Book Clubbing! Successful Book Clubs for Young People

    ERIC Educational Resources Information Center

    Littlejohn, Carol

    2011-01-01

    This practical guide demonstrates how to sponsor a successful, student-led book club for grades K through 12 that is fun, easy-to-implement, and encourages reading. Establishing a book club for children and young people that's self-sustaining and successful long-term is a challenge that this book addresses and conquers. According to recent…

  2. 7 CFR 701.44 - Agricultural Conservation Program (ACP) contracts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Agricultural Conservation Program (ACP) contracts. 701... AGENCY, DEPARTMENT OF AGRICULTURE AGRICULTURAL CONSERVATION PROGRAM EMERGENCY CONSERVATION PROGRAM AND CERTAIN RELATED PROGRAMS PREVIOUSLY ADMINISTERED UNDER THIS PART § 701.44 Agricultural...

  3. 4-H Club Goat Guide.

    ERIC Educational Resources Information Center

    Brown, R. Kipp

    This guide provides information for 4-H Club members who have decided on a club goat project. Topics include general information in the following areas: show rules; facilities and equipment (barns/sheds, fences, feeders, water containers, and equipment); selection (structural correctness, muscle, volume and capacity, style and balance, and growth…

  4. School Book Club Expurgation Practices.

    ERIC Educational Resources Information Center

    Keresey, Gayle

    1984-01-01

    Discusses expurgation practices (deletion, excision, alteration, obliteration of parts of books) of major school book clubs--Scholastic, Xerox's Read Book Club, Troll Associates--as identified by Intellectual Freedom Committee of Young Adult Services Division of the American Library Association. Implications for school libraries are noted.…

  5. The DUDES Club

    PubMed Central

    Gross, Paul A.; Efimoff, Iloradanon; Patrick, Lyana; Josewski, Viviane; Hau, Keith; Lambert, Sandy; Smye, Victoria

    2016-01-01

    Abstract Problem addressed In Canada, there are few health promotion programs for men, particularly programs focused on indigenous and other men marginalized by social and structural inequities. Objective of program To build solidarity and brotherhood among vulnerable men; to promote health through education, dialogue, and health screening clinics; and to help men regain a sense of pride and fulfilment in their lives. Program description The DUDES Club was established in 2010 as a community-based health promotion program for indigenous men in the Downtown Eastside neighbourhood of Vancouver, BC. Between August 2014 and May 2015, 150 men completed an evaluation survey developed using a logic model approach. Responses were analyzed based on the 4 dimensions of the indigenous medicine wheel (mental, physical, emotional, and spiritual). Evaluation results demonstrated high participant satisfaction and positive outcomes across all 4 dimensions of health and well-being: 90.6% of respondents indicated that the DUDES Club program improved their quality of life. Participants who attended meetings more often experienced greater physical, mental, and social benefits (P < .05). Conclusion Findings indicate that this innovative model is effective in promoting the well-being of mainly indigenous men through culturally safe services in an urban community.

  6. Characterization of a Pseudomonas aeruginosa Fatty Acid Biosynthetic Gene Cluster: Purification of Acyl Carrier Protein (ACP) and Malonyl-Coenzyme A:ACP Transacylase (FabD)

    PubMed Central

    Kutchma, Alecksandr J.; Hoang, Tung T.; Schweizer, Herbert P.

    1999-01-01

    A DNA fragment containing the Pseudomonas aeruginosa fabD (encoding malonyl-coenzyme A [CoA]:acyl carrier protein [ACP] transacylase), fabG (encoding β-ketoacyl-ACP reductase), acpP (encoding ACP), and fabF (encoding β-ketoacyl-ACP synthase II) genes was cloned and sequenced. This fab gene cluster is delimited by the plsX (encoding a poorly understood enzyme of phospholipid metabolism) and pabC (encoding 4-amino-4-deoxychorismate lyase) genes; the fabF and pabC genes seem to be translationally coupled. The fabH gene (encoding β-ketoacyl-ACP synthase III), which in most gram-negative bacteria is located between plsX and fabD, is absent from this gene cluster. A chromosomal temperature-sensitive fabD mutant was obtained by site-directed mutagenesis that resulted in a W258Q change. A chromosomal fabF insertion mutant was generated, and the resulting mutant strain contained substantially reduced levels of cis-vaccenic acid. Multiple attempts aimed at disruption of the chromosomal fabG gene were unsuccessful. We purified FabD as a hexahistidine fusion protein (H6-FabD) and ACP in its native form via an ACP-intein-chitin binding domain fusion protein, using a novel expression and purification scheme that should be applicable to ACP from other bacteria. Matrix-assisted laser desorption–ionization spectroscopy, native polyacrylamide electrophoresis, and amino-terminal sequencing revealed that (i) most of the purified ACP was properly modified with its 4′-phosphopantetheine functional group, (ii) it was not acylated, and (iii) the amino-terminal methionine was removed. In an in vitro system, purified ACP functioned as acyl acceptor and H6-FabD exhibited malonyl-CoA:ACP transacylase activity. PMID:10464226

  7. Club of Rome

    ScienceCinema

    None

    2016-07-12

    Le Club de Rome s'est fait connaître du grand public par la publication du premier ouvrage "Halte à la croissance" qui a fait l'object d'un débat, il y a 2 ans. Le Prof. Tinbergen a commencé par s'adonner à la physique, il est docteur en physique et très tôt il s'est tourné vers les problèmes sociaux économiques. Il est expert auprès des nombreux gouvernements et organisations internationales et il a vu ses travaux couronnés par le prix Nobel en 1969.

  8. Preliminary calibration of the ACP safeguards neutron counter

    NASA Astrophysics Data System (ADS)

    Lee, T. H.; Kim, H. D.; Yoon, J. S.; Lee, S. Y.; Swinhoe, M.; Menlove, H. O.

    2007-10-01

    The Advanced Spent Fuel Conditioning Process (ACP), a kind of pyroprocess, has been developed at the Korea Atomic Energy Research Institute (KAERI). Since there is no IAEA safeguards criteria for this process, KAERI has developed a neutron coincidence counter to make it possible to perform a material control and accounting (MC&A) for its ACP materials for the purpose of a transparency in the peaceful uses of nuclear materials at KAERI. The test results of the ACP Safeguards Neutron Counter (ASNC) show a satisfactory performance for the Doubles count measurement with a low measurement error for its cylindrical sample cavity. The neutron detection efficiency is about 21% with an error of ±1.32% along the axial direction of the cavity. Using two 252Cf neutron sources, we obtained various parameters for the Singles and Doubles rates for the ASNC. The Singles, Doubles, and Triples rates for a 252Cf point source were obtained by using the MCNPX code and the results for the ft8 cap multiplicity tally option with the values of ɛ, fd, and ft measured with a strong source most closely match the measurement results to within a 1% error. A preliminary calibration curve for the ASNC was generated by using the point model equation relationship between 244Cm and 252Cf and the calibration coefficient for the non-multiplying sample is 2.78×10 5 (Doubles counts/s/g 244Cm). The preliminary calibration curves for the ACP samples were also obtained by using an MCNPX simulation. A neutron multiplication influence on an increase of the Doubles rate for a metal ingot and UO2 powder is clearly observed. These calibration curves will be modified and complemented, when hot calibration samples become available. To verify the validity of this calibration curve, a measurement of spent fuel standards for a known 244Cm mass will be performed in the near future.

  9. Developing Preservice Teachers' Knowledge of Science Teaching Through Video Clubs

    NASA Astrophysics Data System (ADS)

    Johnson, Heather J.; Cotterman, Michelle E.

    2015-06-01

    Though an adequate understanding of content is a natural prerequisite of teaching (Carlsen in Journal of Research in Science Teaching 30:471-481, 1993), teachers also need to be able to interpret content in ways that facilitate student learning. How to best support novice teachers in developing and refining their content knowledge for teaching is a crucial and ongoing question for preservice teacher educators. Recently, video clubs are being explored as potential contexts for teacher learning (Barnhart & van Es in Teaching and Teacher Education 45:83-93, 2015; Sherin & Han in Teaching and Teacher Education 20:163-183, 2004). We hypothesized that pairing video clubs with student teaching experiences would provide a forum for preservice teachers to discuss issues relevant to their professional trajectory through exposure to models of peer teaching and opportunities to reflect on practice. In this study, we explored how secondary science preservice teachers used video club to restructure their overall science knowledge into science knowledge for teaching. Our findings suggest that video clubs allowed preservice teachers to access and leverage student thinking and instructional resources to deepen their understanding of science content and trajectories for science learning.

  10. Starting a Planet Protectors Club

    ERIC Educational Resources Information Center

    US Environmental Protection Agency, 2007

    2007-01-01

    If your mission is to teach children how to reduce, reuse, and recycle waste and create the next generation of Planet Protectors, perhaps leading a Planet Protectors Club is part of your future challenges. You don't have to be an expert in waste reduction and recycling to lead a a Planet Protectors Club. You don't even have to be a teacher. You do…

  11. The Continuous Quality Improvement Book Club: Developing a Book Club to Promote Praxis

    ERIC Educational Resources Information Center

    Lyons, Becky; Ray, Chris

    2014-01-01

    This article poses a model for developing a book club to promote praxis. This model is built upon a basic four step framework for developing book clubs and includes specific recommendations to focus the book club on reflection of theory and how to incorporate it into practice. This model will be used to start a book club examining Continuous…

  12. Officer Clubs--Options for Survival

    DTIC Science & Technology

    1990-05-01

    base. 6. T used that club how many times a month for: o+ficial functions social drinkinq break fast lunch dinner . dancing check cashing 7. My last...but ’Our corsoiidate(; club would nave separate dininj, dancing and drinkinq areas ftjr officers and NCOs. wkit chances are needed to improve clubs so...toaether in dining, dancing , and drinking areas) AWC: 28 (21%) ACSC: 24 (22%) SOS: 45 (31%) ൗ. Same question as # 14, but your consolidated club

  13. Book Clubs. What Works Clearinghouse Intervention Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2010

    2010-01-01

    Book clubs provide a reading framework designed to supplement or organize regular classroom reading instruction for students in grades K-8. This review focuses on "Book Club" (Raphael & McMahon, 1994) and "Literature Circles" (Daniels, 2002), but it uses the general lowercase) term "book clubs" to embrace both…

  14. Role Calls for Boys & Girls Clubs

    ERIC Educational Resources Information Center

    D'Allesandro, Lou

    2013-01-01

    The New Hampshire Alliance of Boys & Girls Clubs has come a long way since the inception of the state's first Club in Manchester more than 100 years ago. The goal of the Boys & Girls Clubs of America is to provide youth with programs and services that allow them to realize their full potential as productive members of society. State and…

  15. Facilitating a midwifery book club.

    PubMed

    Chenery-Morris, Samantha

    2012-03-01

    A midwifery student book club was set up at University Campus Suffolk (UCS) with the aim of engaging students in alternative forms of literature relevant to their studies and to enhance their university experience. The book club was well attended by first and second year midwifery students, but less so by third years. There was evidence of informal student engagement with the lecturer through follow up emails about the meetings. Most of the books reviewed were enjoyed, but the responsibility of suggesting a book for their peers to review was deemed too much by some students.

  16. Undergraduate Research in the University of Arizona Astronomy Club

    NASA Astrophysics Data System (ADS)

    Cates, Ian; Towner, A. P.; Walker-LaFollette, A.; Turner, J.; Hardegree-Ullman, K.; Pearson, K.

    2014-01-01

    Participation in research as an undergraduate is an invaluable learning experience that leads to successful post-undergrad studies. Because of this, the University of Arizona Astronomy Club strives to provide multiple opportunities for its members to get involved in research as early as possible. Areas of research covered by our projects include exoplanet research, stellar cycles, and radio observations. These projects cover exoplanet parameterization, the utilization of Kepler data, and various star-formation studies, respectively. Participation in our projects builds stronger data-collecting and reduction skills, while also leading to tangible achievements such poster presentations at AAS, ASP, and DPS, and published papers in astronomical journals.

  17. Club Drugs. The DAWN Report.

    ERIC Educational Resources Information Center

    Substance Abuse and Mental Health Services Administration (DHHS/PHS), Rockville, MD. Office of Applied Studies.

    This report was prepared in response to requests from the media, law enforcement, and community leaders for information about club drugs. By being able to utilize statistics from hospital emergency departments and by compiling statistics on drug-related deaths, the Drug Abuse Warning Network (DAWN) is able to alert parents, educators, and others…

  18. "WOW" (War on Weight) Club

    ERIC Educational Resources Information Center

    Harbour, Jane

    1976-01-01

    The article describes the content and successful use of the "WOW" Club Kit which provides general guidelines and 12 specific meeting outlines for public health nurses, home economics teachers and others with basic nutrition background to use in conducting nutrition and weight control programs in secondary schools. (MS)

  19. Science Club--A Concept

    ERIC Educational Resources Information Center

    Wegner, Claas; Issak, Nicole; Tesch, Katharina; Zehne, Carolin

    2016-01-01

    The following article presents a concept of a science club which was developed by two master's students as a part of their thesis and which has been developed and improved ever since. The extra-curricular concept emphasises pupils' individuality through focusing on problem based leaning, station learning, and mixed age groups. Having joined the…

  20. A Science Club Takes Action

    ERIC Educational Resources Information Center

    LeDee, Olivia; Mosser, Anna; Gamble, Tony; Childs, Greg; Oberhauser, Karen

    2007-01-01

    The after-school science club at Galtier Math, Science, and Technology Elementary Magnet School in St. Paul, Minnesota, learned some valuable lessons when they took newfound knowledge about pollution into their homes. After learning about the effects of various contaminants on health and what informed citizens can do about it, students tested…

  1. Phylogenetic and experimental characterization of an acyl-ACP thioesterase family reveals significant diversity in enzymatic specificity and activity

    PubMed Central

    2011-01-01

    Background Acyl-acyl carrier protein thioesterases (acyl-ACP TEs) catalyze the hydrolysis of the thioester bond that links the acyl chain to the sulfhydryl group of the phosphopantetheine prosthetic group of ACP. This reaction terminates acyl chain elongation of fatty acid biosynthesis, and in plant seeds it is the biochemical determinant of the fatty acid compositions of storage lipids. Results To explore acyl-ACP TE diversity and to identify novel acyl ACP-TEs, 31 acyl-ACP TEs from wide-ranging phylogenetic sources were characterized to ascertain their in vivo activities and substrate specificities. These acyl-ACP TEs were chosen by two different approaches: 1) 24 TEs were selected from public databases on the basis of phylogenetic analysis and fatty acid profile knowledge of their source organisms; and 2) seven TEs were molecularly cloned from oil palm (Elaeis guineensis), coconut (Cocos nucifera) and Cuphea viscosissima, organisms that produce medium-chain and short-chain fatty acids in their seeds. The in vivo substrate specificities of the acyl-ACP TEs were determined in E. coli. Based on their specificities, these enzymes were clustered into three classes: 1) Class I acyl-ACP TEs act primarily on 14- and 16-carbon acyl-ACP substrates; 2) Class II acyl-ACP TEs have broad substrate specificities, with major activities toward 8- and 14-carbon acyl-ACP substrates; and 3) Class III acyl-ACP TEs act predominantly on 8-carbon acyl-ACPs. Several novel acyl-ACP TEs act on short-chain and unsaturated acyl-ACP or 3-ketoacyl-ACP substrates, indicating the diversity of enzymatic specificity in this enzyme family. Conclusion These acyl-ACP TEs can potentially be used to diversify the fatty acid biosynthesis pathway to produce novel fatty acids. PMID:21831316

  2. Acid phosphatase 2 (ACP2) is required for membrane fusion during influenza virus entry

    PubMed Central

    Lee, Jihye; Kim, Jinhee; Son, Kidong; d’Alexandry d’Orengiani, Anne-Laure Pham Humg; Min, Ji-Young

    2017-01-01

    Influenza viruses exploit host factors to successfully replicate in infected cells. Using small interfering RNA (siRNA) technology, we identified six human genes required for influenza A virus (IAV) replication. Here we focused on the role of acid phosphatase 2 (ACP2), as its knockdown showed the greatest inhibition of IAV replication. In IAV-infected cells, depletion of ACP2 resulted in a significant reduction in the expression of viral proteins and mRNA, and led to the attenuation of virus multi-cycle growth. ACP2 knockdown also decreased replication of seasonal influenza A and B viruses and avian IAVs of the H7 subtype. Interestingly, ACP2 depletion had no effect on the replication of Ebola or hepatitis C virus. Because ACP2 is known to be a lysosomal acid phosphatase, we assessed the role of ACP2 in influenza virus entry. While neither binding of the viral particle to the cell surface nor endosomal acidification was affected in ACP2-depleted cells, fusion of the endosomal and viral membranes was impaired. As a result, downstream steps in viral entry were blocked, including nucleocapsid uncoating and nuclear import of viral ribonucleoproteins. Our results established ACP2 as a necessary host factor for regulating the fusion step of influenza virus entry. PMID:28272419

  3. The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron sulfur cluster biogenesis

    PubMed Central

    Van Vranken, Jonathan G; Jeong, Mi-Young; Wei, Peng; Chen, Yu-Chan; Gygi, Steven P; Winge, Dennis R; Rutter, Jared

    2016-01-01

    Mitochondrial fatty acid synthesis (FASII) and iron sulfur cluster (FeS) biogenesis are both vital biosynthetic processes within mitochondria. In this study, we demonstrate that the mitochondrial acyl carrier protein (ACP), which has a well-known role in FASII, plays an unexpected and evolutionarily conserved role in FeS biogenesis. ACP is a stable and essential subunit of the eukaryotic FeS biogenesis complex. In the absence of ACP, the complex is destabilized resulting in a profound depletion of FeS throughout the cell. This role of ACP depends upon its covalently bound 4’-phosphopantetheine (4-PP)-conjugated acyl chain to support maximal cysteine desulfurase activity. Thus, it is likely that ACP is not simply an obligate subunit but also exploits the 4-PP-conjugated acyl chain to coordinate mitochondrial fatty acid and FeS biogenesis. DOI: http://dx.doi.org/10.7554/eLife.17828.001 PMID:27540631

  4. Purification of a tartrate-resistant acid phosphatase (TrACP) from bovine cortical bone matrix

    SciTech Connect

    Lau, K.H.W.; Freeman, T.K.; Baylink, D.J.

    1986-05-01

    It has been previously demonstrated that a partially purified bovine skeletal TrACP showed protein phosphatase (P'ase) activity that was specific for phosphotyrosyl (Ptyr) proteins. They have now purified TrACP activity from bovine cortical bone matrix to apparent homogeneity. The purification procedures included CM-Sepharose ion-exchange, cellulose phosphate affinity, sephacryl S-300 gel filtration and phenyl sepharose affinity chromatographies. Overall yield was > 25% and purification was approximately 2000-fold with a specific activity of 8.15 umol pNPP hydrolyzed/min/mg protein at 37/sup 0/C. The purified enzyme was judged to be homogeneous based on: (i) appearance as a single protein band on SDS-PAGE (silver staining technique) and (ii) distribution analysis of radioiodinated purified TrACP after SDS-PAGE revealing one band of radioactivity at the same positions as the TrACP protein band. M.W. of TrACP was 34,600 as assessed by gel filtration and 32,500 by SDS-PAGE, suggesting that bovine skeletal TrACP exists as active monomer. Analysis of the purified TrACP by isoelectric focusing showed at least 9 bands of enzyme activities with pIs between 4 and 5, indicating micro-heterogenecity. Substrate specificity analyses revealed that the purified TrACP also hydrolyzed nucleotide tri- and di-phosphates, but not monophosphates or other low M.W. phosphoryl esters, and was also capable of hydrolyzing phosphotyrosine (Tyr(P)) and Ptyr proteins with little activity toward other phosphoamino acids or phosphoseryl proteins. Optimal pH was 5.5 for TrACP activity, 6.0 for Tyr(P) P'ase activity and 7.0 for Ptyr protein P'ase activity. Results of these studies represent the first purification of a skeletal TrACP to apparent homogeneity.

  5. Tips for Teens: The Truth about Club Drugs

    MedlinePlus

    ... time. Club drugs affect your body. Different club drugs have different effects on your body. Some common effects include loss of muscle and motor control, blurred vision, and seizures. Club drugs like Ecstasy are stimulants that increase your heart ...

  6. View of yacht club and avila pier, facing west. The ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of yacht club and avila pier, facing west. The San Luis Bay Club is visible on the hill in the background. - San Luis Yacht Club, Avila Pier, South of Front Street, Avila Beach, San Luis Obispo County, CA

  7. Learning and Identity in Overlapping Communities of Practice: Surf Club, School and Sports Clubs

    ERIC Educational Resources Information Center

    Light, Richard; Nash, Melanie

    2006-01-01

    Large numbers of children and young people spend their weekends and holidays engaged in the activities of over 300 surf clubs across Australia each summer. Long term membership in these clubs, beginning from as young as five years of age, forms a significant part of children's and young people's development yet surf clubs have yet to receive…

  8. Effect of ethyl-alpha-hydroxymethylacrylate on selected properties of copolymers and ACP resin composites.

    PubMed

    Antonucci, Joseph M; Fowler, Bruce O; Weir, Michael D; Skrtic, Drago; Stansbury, Jeffrey W

    2008-10-01

    There is an increased interest in the development of bioactive polymeric dental composites and related materials that have potential for mineralized tissue regeneration and preservation. This study explores how the substitution of ethyl alpha-hydroxymethylacryate (EHMA) for 2-hydroxyethyl methacrylate (HEMA) in photo-activated 2,2-bis[p-(2'-hydroxy-3'-methacryloxypropoxy)phenyl]propane (Bis-GMA) and Bis-GMA/tri(ethylene glycol) dimethacrylate (TEGDMA) resins affected selected physicochemical properties of the polymers and their amorphous calcium phosphate (ACP) composites. Rate of polymerization and the degree of conversion (DC) of polymers {EHMA (E), HEMA (H), Bis-GMA/EHMA (BE), Bis-GMA/HEMA (BH), Bis-GMA/TEGDMA/EHMA (BTE) and Bis-GMA/TEGDMA/HEMA (BTH)} were assessed by photo-differential scanning calorimetry and Fourier-Transform Infrared (FTIR) spectroscopy. ACP/BTE and ACP/BTH composites were evaluated for DC, biaxial flexure strength (BFS), water sorption (WS) and mineral ion release. Mid-FTIR and near-IR measurements revealed the following order of decreasing DC: [E, H polymers (97.0%)] > [BE copolymer (89.9%)] > [BH copolymer (86.2%)] > [BTE, BTH copolymers (85.5%)] > [ACP/BTH composite (82.6%)] > [ACP/BTE composite (79.3%)]. Compared to HEMA, EHMA did not adversely affect the BFS of its copolymers and/or ACP composites. Lower WS of BTE copolymers and composites (28% and 14%, respectively, compared to the BTH copolymers and composites) only marginal reduced the ion release from ACP/BTE composites compared to ACP/BTH composites. More hydrophobic ACP composites with acceptable ion-releasing properties were developed by substituting the less hydrophilic EHMA for HEMA.

  9. New Journalism.

    ERIC Educational Resources Information Center

    Fishwick, Marshall, Ed.

    This volume contains a selection of articles which examine, critique, and help to define the phenomenon of new journalism. Included are "Popular Culture and the New Journalism" (Marshall Fishwick), "Entrance" (Richard A. Kallan), "How 'New'?" (George A. Hough III), "Journalistic Primitivism" (Everette E. Dennis), "Wherein Lies the Value?" (Michael…

  10. After Journalism.

    ERIC Educational Resources Information Center

    Jurgensen, Karen; Meyer, Philip

    1992-01-01

    Maintains that the central journalistic function is changing from the transportation of information to its processing. Offers a model for the more sophisticated standard of objectivity needed by the new process-intensive journalism. Discusses changes in journalism training to meet these demands. (SR)

  11. HRD Journals.

    ERIC Educational Resources Information Center

    1996

    This document consists of four papers presented during a symposium on human resource development (HRD) journals moderated by Peter W.J. Schramade at the 1996 conference of the Academy of Human Resource Development. "Refereed Journals: The Cornerstone of a Developing Profession" (Gary N. McLean) describes the purpose, format, success, and…

  12. Caveats of an English Conversation Club.

    ERIC Educational Resources Information Center

    Simpson, JoEllen; Ossa, Carlos E.; Rutter, Frank P.

    1999-01-01

    Describes an English conversation club that was initiated at the Universidad del Valle in Cali, Colombia. Suggests ways in which other university communities can better serve their English-speaking populations by creating a similar English conversation club. (Author/VWL)

  13. Healthy Living Initiative: Running/Walking Club

    ERIC Educational Resources Information Center

    Stylianou, Michalis; Kulinna, Pamela Hodges; Kloeppel, Tiffany

    2014-01-01

    This study was grounded in the public health literature and the call for schools to serve as physical activity intervention sites. Its purpose was twofold: (a) to examine the daily distance covered by students in a before-school running/walking club throughout 1 school year and (b) to gain insights on the teachers perspectives of the club.…

  14. What A Booster Club Can Do.

    ERIC Educational Resources Information Center

    Hidinger, George

    This speech was presented at the 1976 American Alliance for Health, Physical Education, and Recreation national convention by the principal of an Iowa high school. It discusses the development and effectiveness of the Jefferson High School Booster Club which was developed by an interested parent and has been quite successful. The club has assisted…

  15. Boys and Girls: Join the Club

    ERIC Educational Resources Information Center

    D'Allesandro, Lou; Wool, Michael; McKenzie, Mary Alice

    2012-01-01

    Boys & Girls Clubs of America count 4,000 community-based clubs serving more than 4 million young people through membership and community outreach. They provide a safe place to spend time during non-school hours and the summer as an alternative to the streets or being home alone--a place to play, have fun and learn. Boys & Girls Clubs…

  16. STEM Club Participation and STEM Schooling Outcomes

    ERIC Educational Resources Information Center

    Gottfried, Michael A.; Williams, Darryl N.

    2013-01-01

    To develop a more robust understanding of the relationship between non-formal, school-based STEM activities and students' success and persistence in STEM fields, this study evaluates how math club participation influences math GPA and how science club participation influences science GPA. Additionally, this study evaluates how math or science club…

  17. Health promotion profile of youth sports clubs in Finland: club officials' and coaches' perceptions.

    PubMed

    Kokko, Sami; Kannas, Lasse; Villberg, Jari

    2009-03-01

    The purpose of this article is to examine the current health promotion orientation of youth sports clubs in Finland in view of the standards created previously for the health promoting sports club (HPSC). Ninety-seven youth sports clubs participated, and 273 sports club officials and 240 coaches answered the questionnaires. To describe clubs health promotion orientations, an HPSC index was created. The HPSC index was formulated on sub-indices by factor analysis. The sub-indices were: policy, ideology, practice and environment indexes. The results indicate that youth sports clubs are fairly health promoting in general. On average, the clubs fulfilled 12 standards for HPSC out of 22. Every fourth club was categorized as higher health promoting (> or = 15 fulfilled standards), and every third as lower health promoting (<11 fulfilled standards). The variation between clubs was wide. The clubs that had been recognized as exemplary and hence certified by the Young Finland Association were more likely to recognize health promotion than non-certified clubs (OR = 2.36, p = 0.016). The sports club officials were twice as likely to evaluate their clubs as higher health promoting than the coaches (OR = 2.04, p = 0.041). Under the sub-indices, ideologies were recognized best, others less. These findings indicate that minority of the youth sports clubs have realized health promotion comprehensively as a part of their activities. There is a lot of need for development, especially in the area of health promotion policies and practices. The instruments used proved valid and reliable and can therefore be recommended for international use.

  18. Dimethylformamide as a cryoprotectant for canine semen diluted and frozen in ACP-106C.

    PubMed

    Mota Filho, A C; Teles, C H A; Jucá, R P; Cardoso, J F S; Uchoa, D C; Campello, C C; Silva, A R; Silva, L D M

    2011-10-15

    The objective was to assess the effect of adding various concentrations of dimethylformamide on characteristics of canine semen diluted in powdered coconut water (ACP-106C; ACP Biotecnologia, Fortaleza, CE, Brazil) and frozen at -196°C. Fifteen ejaculates were collected by manual stimulation from five adult Boxer dogs. The sperm-rich fraction was diluted in ACP-106C (ACP Biotecnologia) containing 10% egg yolk and divided into four aliquots. The cryoprotectants used for each aliquot were 6% glycerol (control group; CG) or 2%, 4%, or 6% dimethylformamide (DF2, DF4, and DF6, respectively). After thawing, total motility (mean ± SEM) for CG (58.4 ± 24.6) was higher (P < 0.05) than that of the other groups (2% dimethylformamide, 24.4 ± 12.3; 4% dimethylformamide, 26.5 ± 16.1; and 6% dimethylformamide, 21.7 ± 17.9). Furthermore, there was a greater percentage of fast, average, and slow moving sperm (assessed with computer-aided semen analysis; CASA) in CG in comparison with the other three groups. Therefore, based on concentrations tested in this study, dimethylformamide, together with ACP-106C (ACP Biotecnologia) and 10% egg yolk as a diluent, yielded unsatisfactory in vitro results for freezing canine semen.

  19. Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia

    PubMed Central

    Byrd, John C; Harrington, Bonnie; O’Brien, Susan; Jones, Jeffrey A; Schuh, Anna; Devereux, Steve; Chaves, Jorge; Wierda, William G; Awan, Farrukh T; Brown, Jennifer R; Hillmen, Peter; Stephens, Deborah M; Ghia, Paolo; Barrientos, Jacqueline C; Pagel, John M; Woyach, Jennifer; Johnson, Dave; Huang, Jane; Wang, Xiaolin; Lannutti, Brian J; Covey, Todd; Fardis, Maria; McGreivy, Jesse; Hamdy, Ahmed; Rothbaum, Wayne; Izumi, Raquel; Diacovo, Thomas G; Johnson, Amy J; Furman, Richard R

    2016-01-01

    Background Irreversible inhibition of Bruton tyrosine kinase (Btk) by ibrutinib represents a significant therapeutic advance for chronic lymphocytic leukemia (CLL). However, ibrutinib also irreversibly inhibits alternative kinase targets, which potentially compromise its therapeutic index. Acalabrutinib (ACP-196) is a more selective irreversible Btk inhibitor specifically designed to improve upon the safety and efficacy of first generation Btk inhibitors. Methods Sixty-one patients with relapsed CLL were treated in a phase 1–2 multicenter study designed to assess the safety, efficacy, pharmacokinetics and pharmacodynamics of oral acalabrutinib. Patients were continuously treated with acalabrutinib 100 to 400 mg once daily in the dose-escalation portion of the study, and 100 mg twice daily in the expansion portion. Results Patient demographics include a median age of 62 years; median of 3 prior therapies; 31% del(17)(p13.1) and 75% unmutated immunoglobulin heavy chain variable genes. No dose-limiting toxicities occurred. The most common adverse events observed were headache (43%), diarrhea (39%) and increased weight (26%). Most adverse events were Grade 1–2. At a median follow-up of 14.3 months, the best overall response rate was 95%, including 85% partial response, 10% partial response with lymphocytosis and 5% stable disease. In patients with del(17)(p13.1), the best overall response was 100%. No cases of Richter’s transformation and only 1 CLL progression have occurred. Conclusions Acalabrutinib is a highly selective Btk inhibitor that provides effective and well tolerated treatment for patients with relapsed CLL, including those with del(17)(p13.1). PMID:26641137

  20. Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate

    PubMed Central

    Maloney, Finn P.; Gerwick, Lena; Gerwick, William H.; Sherman, David H.; Smith, Janet L.

    2016-01-01

    Alkyl branching at the β position of a polyketide intermediate is an important variation on canonical polyketide natural product biosynthesis. The branching enzyme, 3-hydroxy-3-methylglutaryl synthase (HMGS), catalyzes the aldol addition of an acyl donor to a β-keto-polyketide intermediate acceptor. HMGS is highly selective for two specialized acyl carrier proteins (ACPs) that deliver the donor and acceptor substrates. The HMGS from the curacin A biosynthetic pathway (CurD) was examined to establish the basis for ACP selectivity. The donor ACP (CurB) had high affinity for the enzyme (Kd = 0.5 μM) and could not be substituted by the acceptor ACP. High-resolution crystal structures of HMGS alone and in complex with its donor ACP reveal a tight interaction that depends on exquisite surface shape and charge complementarity between the proteins. Selectivity is explained by HMGS binding to an unusual surface cleft on the donor ACP, in a manner that would exclude the acceptor ACP. Within the active site, HMGS discriminates between pre- and postreaction states of the donor ACP. The free phosphopantetheine (Ppant) cofactor of ACP occupies a conserved pocket that excludes the acetyl-Ppant substrate. In comparison with HMG-CoA (CoA) synthase, the homologous enzyme from primary metabolism, HMGS has several differences at the active site entrance, including a flexible-loop insertion, which may account for the specificity of one enzyme for substrates delivered by ACP and the other by CoA. PMID:27573844

  1. Recovery and cryopreservation of epididymal sperm from agouti (Dasiprocta aguti) using powdered coconut water (ACP-109c) and Tris extenders.

    PubMed

    Silva, M A; Peixoto, G C X; Santos, E A A; Castelo, T S; Oliveira, M F; Silva, A R

    2011-10-01

    The objective was to compare the use of powdered coconut water (ACP-109c; ACP Biotecnologia, Fortaleza, CE, Brazil) and Tris extenders for recovery and cryopreservation of epididymal sperm from agouti. The caudae epididymus and proximal ductus deferens from 10 sexually mature agoutis were subjected to retrograde washing using ACP-109c (ACP Biotecnologia) or Tris. Epididymal sperm were evaluated for motility, vigor, sperm viability, membrane integrity, and morphology. Samples were centrifuged, and extended in the same diluents plus egg yolk (20%) and glycerol (6%), frozen in liquid nitrogen, and subsequently thawed at 37°C for 1 min, followed by re-evaluation of sperm characteristics. The two extenders were similarly efficient for epididymal recovery, with regard to the number and quality of sperm recovered. However, for both extenders, sperm quality decreased (P < 0.05) after centrifugation and dilution. After sperm cryopreservation and thawing, there were (mean ± SEM) 26.5 ± 2.6% motile sperm with 2.6 ± 0.2 vigor in the ACP-109c (ACP Biotecnologia) group, which was significantly better than 9.7 ± 2.6% motile sperm with 1.2 ± 0.3 vigor in Tris. In conclusion, agouti epididymal sperm were successfully recovered using either ACP-109c (ACP Biotecnologia) or Tris extenders; however, ACP-109c (ACP Biotecnologia) was a significantly better extender for processing and cryopreserving these sperm.

  2. The Drosophila melanogaster seminal fluid protein Acp62F is a protease inhibitor that is toxic upon ectopic expression.

    PubMed Central

    Lung, Oliver; Tram, Uyen; Finnerty, Casey M; Eipper-Mains, Marcie A; Kalb, John M; Wolfner, Mariana F

    2002-01-01

    Drosophila melanogaster seminal fluid proteins stimulate sperm storage and egg laying in the mated female but also cause a reduction in her life span. We report here that of eight Drosophila seminal fluid proteins (Acps) and one non-Acp tested, only Acp62F is toxic when ectopically expressed. Toxicity to preadult male or female Drosophila occurs upon one exposure, whereas multiple exposures are needed for toxicity to adult female flies. Of the Acp62F received by females during mating, approximately 10% enters the circulatory system while approximately 90% remains in the reproductive tract. We show that in the reproductive tract, Acp62F localizes to the lumen of the uterus and the female's sperm storage organs. Analysis of Acp62F's sequence, and biochemical assays, reveals that it encodes a trypsin inhibitor with sequence and structural similarities to extracellular serine protease inhibitors from the nematode Ascaris. In light of previous results demonstrating entry of Acp62F into the mated female's hemolymph, we propose that Acp62F is a candidate for a molecule to contribute to the Acp-dependent decrease in female life span. We propose that Acp62F's protease inhibitor activity exerts positive protective functions in the mated female's reproductive tract but that entry of a small amount of this protein into the female's hemolymph could contribute to the cost of mating. PMID:11805057

  3. The Sierra Club--A History. Part 2: Conservation

    ERIC Educational Resources Information Center

    Strong, Douglas H.

    1977-01-01

    This second article on Sierra Club history brings the Club into the 1960s. It relates early conservation activities of the club, such as the efforts to save the Hetch Hetchy Valley. The campaign against construction of a dam in Dinosaur National Monument helped establish the club as a national organization. (MA)

  4. Biomedical journals: keeping up and reading critically.

    PubMed

    Chase, Karen L; DiGiacomo, Ronald F; Van Hoosier, Gerald L

    2006-09-01

    By extrapolation from studies of physicians, knowledge and practice of laboratory animal medicine and science are expected to become progressively more outdated the longer practitioners are out of school. Keeping up with current literature and practice is a challenge that necessitates the use of many different sources of continuing education. Both veterinarians and physicians consistently list journals as the most beneficial source of new information. Accordingly, they must select from the veterinary and biomedical literature articles that report original studies and systematic reviews and recognize and respond to valid new knowledge to improve diagnostic and therapeutic approaches and maintain consistent clinical skills. Other objectives include selecting journals for general information and for information relevant or specific to one's field of research. Lastly, candidates for board certification need to read articles from journals that potentially provide the basis for questions on the examination. 'High-impact' journals should be identified, and articles should be reviewed critically. In a survey of recent candidates for laboratory animal medicine board examination, these journals included Contemporary Topics (now JAALAS), Comparative Medicine, ILAR Journal, and Laboratory Animals. Strategies for coping with the challenge of staying current with the literature include wise use of technology, journal clubs, and consultation with colleagues. A laboratory animal practitioner can become a better scientist and clinician by evaluating the research performed by others. Thorough, critical review of biomedical literature is paramount to these goals.

  5. Efficacious long-term cooling and freezing of Sapajus apella semen in ACP-118(®).

    PubMed

    Leão, D L; Miranda, S A; Brito, A B; Lima, J S; Santos, R R; Domingues, S F S

    2015-08-01

    The objectives of the present study were to test the effect of coconut water solution (CWS), TES-TRIS and ACP-118(®) on the seminal cooling and cryopreservation of semen from capuchin monkeys (Sapajus apella). Semen was collected from six males by electro-ejaculation, diluted in TES-TRIS, CWS or ACP-118(®), and maintained at 4°C for 28h. Semen was subsequently evaluated (Experiment I) or cryopreserved in the presence of different glycerol concentrations (3%, 5% or 7%) (Experiment II). ACP-118(®) was the preferred extender to preserve sperm motility and viability after 28h incubation at 4°C. Cooled sperm were successfully frozen-thawed in a medium containing 3% glycerol. After thawing, sperm retained the capacity to fertilize oocytes and zygotes were obtained. In conclusion, ACP-118(®) can be effectively and efficiently used as extender for the cooling of S. apella semen. Furthermore, cryopreservation using ACP-118(®) by adding 3% glycerol is suitable to maintain sperm morphology and the capacity of these cells to fertilize in vitro.

  6. [Constructing an ACP Simulation-Situation Communication Training Program for Patients With Chronic Kidney Disease].

    PubMed

    Chen, Jui-O; Lin, Chiu-Chu

    2016-06-01

    The aging population and changing lifestyles have lead to the increased general risk of chronic kidney disease. Taiwan currently has the highest incidence and prevalence of end-stage renal disease (ESRD) of any country or region in the world. Hemodialysis patients must endure comorbidities and face the uncertainties of death. The best way to achieve a good death is for patients to sign advance care planning (ACP). However, the key factors contributing to low ACP signature rates have been the lack of communication skills and related training among medical staffs. This article explores the dilemma of ACP using an example of chronic kidney disease (CKD) and proposes a theory-based approach to develop a theoretical framework for an ACP simulation-situation communication training program that integrates the simulation situation model, PREPARED model, and scaffolding theory. Readers may use this framework to design ACP simulation-situation communication training programs that conform to their own conditions and then test the effectiveness and feasibility of these programs in clinical settings.

  7. A specific acyl-ACP thioesterase implicated in medium-chain fatty acid production in immature cotyledons of Umbellularia californica.

    PubMed

    Pollard, M R; Anderson, L; Fan, C; Hawkins, D J; Davies, H M

    1991-02-01

    Umbellularia californica (California Bay) seeds accumulate 10:0 and 12:0 as principal reserve fatty acyl groups. An in vitro fatty acid synthesis system from the developing cotyledons produces chiefly 10:0 and 12:0, in approximately the same proportions as the intact tissue. The kinetics of acyl thioester and free fatty acid formation in this system suggest that a medium-chain specific acyl-acyl-carrier protein (ACP) hydrolysis mechanism is responsible for the preponderance of medium-chain products. A crude extract of the developing cotyledons exhibits hydrolytic activity toward acyl-ACPs, with marked preference for 12:0-ACP and 18:1-ACP in the test series 6:0, 8:0, 10:0, 11:0, 12:0, 14:0, 16:0, and 18:1-ACPs. Partial purification of the 12:0-ACP hydrolytic activity has resulted in its separation from the 18:1-ACP hydrolase(s) and the 12:0-coenzyme A hydrolase(s) that are also present, thereby demonstrating its specificity for the 12-carbon acyl chain length and the ACP derivative. During cotyledon development, as the proportion of medium-chain to other fatty acyl groups increases, the extractable yield of this activity also increases substantially. Collectively these results suggest a role for this 12-ACP thioesterase in medium-chain production in vivo.

  8. Florida, National Space Club Embrace Commercial Endeavors

    NASA Video Gallery

    NASA's Commercial Crew Program (CCP) Manager Ed Mango and Florida's Lt. Gov. Jennifer Carroll were guest speakers at the National Space Club Florida Committee's luncheon at the Radisson Resort at t...

  9. Ecosystem Journalism

    ERIC Educational Resources Information Center

    Robertson, Amy; Mahlin, Kathryn

    2005-01-01

    If the organisms in a prairie ecosystem created a newspaper, what would it look like? What important news topics of the ecosystem would the organisms want to discuss? Imaginative and enthusiastic third-grade students were busy pondering these questions as they tried their hands at "ecosystem journalism." The class had recently completed…

  10. Advanced spent fuel conditioning process (ACP) progress with respect to remote operation and maintenance

    SciTech Connect

    Lee, Hyo Jik; Lee, Jong Kwang; Park, Byung Suk; Yoon, Ji Sup

    2007-07-01

    Korea Atomic Energy Research Institute (KAERI) has been developing an Advanced Spent Fuel Conditioning Process (ACP) to reduce the volume of spent fuel, and the construction of the ACP facility (ACPF) for a demonstration of its technical feasibility has been completed. In 2006 two inactive demonstrations were performed with simulated fuels in the ACPF. Accompanied by process equipment performance tests, its remote operability and maintainability were also tested during that time. Procedures for remote operation tasks are well addressed in this study and evaluated thoroughly. Also, remote maintenance and repair tasks are addressed regarding some important modules with a high priority order. The above remote handling test's results provided a lot of information such as items to be revised to improve the efficiency of the remote handling tasks. This paper deals with the current status of ACP and the progress of remote handling of ACPF. (authors)

  11. USGS tethered ACP platforms: New design means more safety and accuracy

    USGS Publications Warehouse

    Morlock, S.E.; Stewart, J.A.; Rehmel, M.S.

    2004-01-01

    The US Geological Survey has developed an innovative tethered platform that supports an Acoustic Current Profiler (ACP) in making stream-flow measurements (use of the term ACP in this article refers to a class of instruments and not a specific brand name or model). The tethered platform reduces the hazards involved in conventional methods of stream-flow measurement. The use of the platform reduces or eliminates time spent by personnel in streams and boats or on bridges and cableway and stream-flow measurement accuracy is increased.

  12. 76 FR 27253 - Safety Zone; Catawba Island Club Fireworks, Catawba Island Club, Port Clinton, OH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Catawba Island Club Fireworks, Catawba Island Club, Port Clinton, OH AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast... Clinton, Ohio. This zone is intended to restrict vessels from portions of Lake Erie for the Catawba...

  13. 78 FR 58880 - Safety Zone; Catawba Island Club Wedding Event, Catawba Island Club, Catawba Island, OH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-25

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Catawba Island Club Wedding Event, Catawba Island Club, Catawba Island, OH ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing... Island. DATES: This rule will be effective and enforced from 7:50 p.m. until 8:30 p.m. on October 5,...

  14. Journal standards.

    PubMed

    Jackson, R

    2003-08-01

    Despite its many imperfections, the peer review process is a firmly established quality control system for scientific literature. It gives readers some assurance that the work and views that are reported meet standards that are acceptable to a journal. Maureen Revington's editorial in a recent issue of the Australian Veterinary Journal (Revington2002) gives a good concise warts and all overview of the process and is well worth reading. I have some concerns about several articles in the December 2002 issue of the New Zealand Veterinary Journal (Volume 50, Number 6), devoted to the health and welfare of farmed deer, that relate to extensive citing of non-peer reviewed papers. I can understand the need for information to flow from researchers to the wider community but that need is already satisfied by publications such as the proceedings of the Deer Branch of the New Zealand Veterinary Association and Proceedings of the New Zealand Society of Animal Production. Non-peer reviewed papers have been cited in the Journal in the past but never to the extent displayed in this particular issue. It degrades the peer-review process and creates an added burden for reviewers who are forced to grapple with the uncertainties of the science in non-peer reviewed citations. One of my fears is that this process allows science from non peer reviewed articles to be legitimised by its inclusion in a peer reviewed journal and perhaps go on to be accepted as dogma. This is a real danger given the difficulties associated with tracing back to original citations and the increasing volume of scientific literature. It also affords opportunities for agencies to pick up questionable and doubtful science and tout it as support for their products or particular points of view. If deer researchers choose to publish most of their work in proceedings then so be it. However this approach, which seems to becoming increasingly prevalent in the deer sector, is questionable from an established science point

  15. Introducing an Absolute Cavity Pyrgeometer (ACP) for Improving the Atmospheric Longwave Irradiance Measurement (Poster)

    SciTech Connect

    Reda, I.; Stoffel, T.

    2012-03-01

    Advancing climate change research requires accurate and traceable measurement of the atmospheric longwave irradiance. Current measurement capabilities are limited to an estimated uncertainty of larger than +/- 4 W/m2 using the interim World Infrared Standard Group (WISG). WISG is traceable to the Systeme international d'unites (SI) through blackbody calibrations. An Absolute Cavity Pyrgeometer (ACP) is being developed to measure absolute outdoor longwave irradiance with traceability to SI using the temperature scale (ITS-90) and the sky as the reference source, instead of a blackbody. The ACP was designed by NREL and optically characterized by the National Institute of Standards and Technology (NIST). Under clear-sky and stable conditions, the responsivity of the ACP is determined by lowering the temperature of the cavity and calculating the rate of change of the thermopile output voltage versus the changing net irradiance. The absolute atmospheric longwave irradiance is then calculated with an uncertainty of +/- 3.96 W/m2 with traceability to SI. The measured irradiance by the ACP was compared with the irradiance measured by two pyrgeometers calibrated by the World Radiation Center with traceability to the WISG.

  16. High School Political Clubs--A First Amendment Right

    ERIC Educational Resources Information Center

    Levy, Martin R.

    1977-01-01

    The First and Fourteenth Amendments guarantee that high school students may form political clubs. Such clubs should be recognized by the school unless they prevent others from learning, interrupt class, or violate valid school rules. (Author/IRT)

  17. Contextual view to northnorthwest of Burton Park Club House and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view to north-northwest of Burton Park Club House and Amphitheater (90 mm lens). - Burton Park, Club House & Amphitheater, Adjacent ot south end of Chestnut Avenue, San Carlos, San Mateo County, CA

  18. Contextual view to southwest of Burton Park Club House and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view to southwest of Burton Park Club House and Amphitheater (90mm lens). Pedestals within Amphitheater are supports for bench seating - Burton Park, Club House & Amphitheater, Adjacent ot south end of Chestnut Avenue, San Carlos, San Mateo County, CA

  19. Contextual view to north of Burton Park Club House and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view to north of Burton Park Club House and Amphitheater, taken from adjacent circular drive (135mm lens) - Burton Park, Club House & Amphitheater, Adjacent ot south end of Chestnut Avenue, San Carlos, San Mateo County, CA

  20. KIND Clubs: A Humane Education Innovation That's Working.

    ERIC Educational Resources Information Center

    Finch, Patty

    1990-01-01

    The Kids in Nature's Defense (KIND) Club and the "adopt" a teacher program are described. The importance of animals and the environment is emphasized. Information on how to start a KIND Club is provided. (KR)

  1. 7. OFFICERS' CLUB INTERIOR, FIRST FLOOR, HALLWAY AND GATHERING ROOMS, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. OFFICERS' CLUB INTERIOR, FIRST FLOOR, HALLWAY AND GATHERING ROOMS, SOUTHWEST VIEW. - Wright-Patterson Air Force Base, Brick Officers' Quarters, Officers' Club, Area A, Dayton, Montgomery County, OH

  2. Detail, exterior side of doubleplanked north end, Burton Park Club ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Detail, exterior side of double-planked north end, Burton Park Club House, view to south-southwest (135mm lens). - Burton Park, Club House & Amphitheater, Adjacent ot south end of Chestnut Avenue, San Carlos, San Mateo County, CA

  3. Interior detail, fireplace, main room, Burton Park Club House, view ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Interior detail, fireplace, main room, Burton Park Club House, view to northwest (135mm lens). - Burton Park, Club House & Amphitheater, Adjacent ot south end of Chestnut Avenue, San Carlos, San Mateo County, CA

  4. Oblique view, north end and west side, Burton Park Club ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Oblique view, north end and west side, Burton Park Club House, view to south (90mm lens). - Burton Park, Club House & Amphitheater, Adjacent ot south end of Chestnut Avenue, San Carlos, San Mateo County, CA

  5. Detail, front doors, Burton Park Club House, view to west ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Detail, front doors, Burton Park Club House, view to west northwest (135mm lens). Note simplified pilasters flanking doors. - Burton Park, Club House & Amphitheater, Adjacent ot south end of Chestnut Avenue, San Carlos, San Mateo County, CA

  6. View of the yacht club facing south from Front Street. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of the yacht club facing south from Front Street. Harbor storage building and restrooms are on the left. - San Luis Yacht Club, Avila Pier, South of Front Street, Avila Beach, San Luis Obispo County, CA

  7. Corn Clubs: Building the Foundation for Agricultural and Extension Education

    ERIC Educational Resources Information Center

    Uricchio, Cassandra; Moore, Gary; Coley, Michael

    2013-01-01

    Corn clubs played an important role in improving agriculture at the turn of the 20th century. Corn clubs were local organizations consisting of boys who cultivated corn on one acre of land under the supervision of a local club leader. The purpose of this historical research study was to document the organization, operation, and outcomes of corn…

  8. Health Promotion Guidance Activity of Youth Sports Clubs

    ERIC Educational Resources Information Center

    Kokko, Sami; Kannas, Lasse; Villberg, Jari; Ormshaw, Michael

    2011-01-01

    Purpose: This paper aims to clarify the extent to which youth sports clubs guide their coaches to recognise health promotion as a part of the coaching practice. The guidance activity of clubs is seen parallel to internal organisational communication. Design/methodology/approach: A survey of 93 (from 120, 78 per cent) youth sports clubs in Finland…

  9. Contextual view to northwest of Burton Park Club House and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view to northwest of Burton Park Club House and Amphitheater. Steps lead up from wings of stage area to club house grade level (135mm lens). - Burton Park, Club House & Amphitheater, Adjacent ot south end of Chestnut Avenue, San Carlos, San Mateo County, CA

  10. The 4-H Club Meeting: An Essential Youth Development Strategy

    ERIC Educational Resources Information Center

    Cassels, Alicia; Post, Liz; Nestor, Patrick I.

    2015-01-01

    The club meeting has served as a key delivery method for 4-H programming across the United States throughout its history. A survey of WV 4-H community club members reinforces the body of evidence that the 4-H club meeting is an effective vehicle for delivering positive youth learning opportunities within the umbrella of the Essential Elements of…

  11. An Exploration of Recent Club Drug Use among Rave Attendees

    ERIC Educational Resources Information Center

    Yacoubian, George S.; Peters, Ronald J.

    2007-01-01

    Raves are characterized by large numbers of youth dancing for long periods of time and by the use of "club drugs," such as 3, 4-methylenedioxymethamphetamine (MDMA or "ecstasy"). While a small body of research has explored the use of ecstasy and other club drugs (EOCD) among club rave attendees in the United States, we are…

  12. Integrating Current Meteorological Research Through Club Fundraising

    NASA Astrophysics Data System (ADS)

    Gill, S. S.; Kauffman, C. M.

    2003-12-01

    Earth science programs whose focus is primarily an undergraduate education do not often have the funding to take students to very many conferences which could expose the student to new research as well as possible graduate programs and employment opportunities. Conferences also give the more enthusiastic and hardworking students a venue in which to present their research to the meteorological community. In addition, the California University services largely lower income counties, which make student attendance at conferences even more difficult even though the student in SW PA may be individually motivated. This issue is compounded by the fact that the Meteorology Concentration within the Earth Science department at Cal U is composed of only two full-time Professors, which limits the amount of research students can be exposed to within a classroom setting. New research ideas presented at conferences are thus an important mechanism for broadening what could be an isolated program. One way in which the meteorology program has circumvented the funding problem to a certain extent is through an active student club. With nearly 60 majors (3/4 of which are active in club activities, the meteorology club is able to execute a variety of fundraising activities. Money that is raised can then request from student services matching funds. Further money is given to clubs, which are very active not only in fundraising, but using that money for academic related activities. For the last 3 years the club budget has been in the neighborhood of \\$4500. The money has then been used to partially finance student registration and accommodation costs making conference attendance much more affordable. Normally 8-16 students attend conferences that they would otherwise not be able to attend without great expense. There are times when more than 16 students wish to attend, but travel arrangements prohibit more than 16. Moreover club money is also use to supplement student costs on a summer

  13. Profiles of club drug users in treatment.

    PubMed

    Maxwell, Jane Carlisle; Spence, Richard T

    2005-01-01

    There is little in the literature about treatment of persons with problems with "club" or "party" drugs. This paper looks at the characteristics of individuals admitted to treatment for primary, secondary, or tertiary problems with club drugs such as ecstasy, gamma-hydroxybutyrate (GHB), ketamine, flunitrazepam (Rohypnol), methamphetamine, and hallucinogens (e.g., LSD) in programs funded by the Texas Commission on Alcohol and Drug Abuse. Some 38,350 unduplicated records from 1988 through 2003 of persons admitted with problems with club drugs were compared against users of alcohol or other drugs. Club drug users were more impaired on five of six Addiction Severity Index (ASI) indices at admission and they were more likely to use multiple substances more often. They were more likely than users of alcohol or other drugs to complete treatment, but this varied by drug. At follow-up 90 days after discharge, club drug users continued to report more ASI problems. Profiles of these clients show that ecstasy use has spread beyond the club culture, as indicated by the changes in client demographics over time. GHB clients presented a mixed picture of severe problems at admission and good response to treatment. Hallucinogen clients were young and less likely to complete treatment, while Rohypnol users were on the Texas-Mexico border. The methamphetamine epidemic has resulted in increased admissions, and the proportion of "Ice" smokers has increased. However, methamphetamine clients were less likely to complete treatment and their higher level of problems at admission and follow-up are of concern. Of special note are the indications of co-occurring problems and the need for both mental health and substance dependence treatment for some clients.

  14. Power and control in gay strip clubs.

    PubMed

    DeMarco, Joseph R G

    2007-01-01

    The gay strip club is a place in which more than displays of male beauty take place. The mix of customers, performers, liquor, and nudity results in fascinating dynamics. Of interest in this article are the power relationships and issues of control played out both among and between strippers and customers. Based on extensive participant observation conducted in eight cities and numerous bars/clubs and including more than 150 in-depth interviews, this article concerns just one aspect of the world of male strippers who perform for men.

  15. Constitutional Law--State Action--Golden v. Biscayne Bay Yacht Club: Preventing Discrimination by Private Clubs

    ERIC Educational Resources Information Center

    Patrick, Michael W.

    1976-01-01

    Although the Supreme Court has refrained from answering whether the membership policies of private clubs can be attacked on state action grounds, the Fifth Circuit Court of Appeals held in the affirmative in Golden v. Biscayne Bay Yacht Club. It ruled that leasing publicly owned bay bottom land to a yacht club constituted sufficient state…

  16. Solution Structure of 4'-Phosphopantetheine - GmACP3 from Geobacter Metallireducens: A Specialized Acyl Carrier Protein with Atypical Structural Features and a Putative Role in Lipopolysaccharide Biosyntheses

    SciTech Connect

    Ramelot, Theresa A.; Smola, Matthew J.; Lee, Hsiau-Wei; Ciccosanti, Colleen; Hamilton, Keith; Acton, Thomas; Xiao, Rong; Everett, John K.; Prestegard, James H.; Montelione, Gaetano; Kennedy, Michael A.

    2011-03-08

    GmACP3 from Geobacter metallireducens is a specialized acyl carrier protein (ACP) whose gene, gmet_2339, is located near genes encoding many proteins involved in lipopolysaccharide (LPS) biosynthesis, indicating a likely function for GmACP3 in LPS production. By overexpression in Escherichia coli, about 50% holo-GmACP3 and 50% apo-GmACP3 were obtained. Apo-GmACP3 exhibited slow precipitation and non-monomeric behavior by 15NNMRrelaxation measurements. Addition of 4'-phosphopantetheine (4'-PP) via enzymatic conversion by E. coli holo-ACP synthase resulted in stable >95% holo-GmACP3 that was characterized as monomeric by 15N relaxation measurements and had no indication of conformational exchange. We have determined a high-resolution solution structure of holo-GmACP3 by standard NMR methods, including refinement with two sets of NH residual dipolar couplings, allowing for a detailed structural analysis of the interactions between 4'-PP and GmACP3. Whereas the overall four helix bundle topology is similar to previously solved ACP structures, this structure has unique characteristics, including an ordered 4'-PP conformation that places the thiol at the entrance to a central hydrophobic cavity near a conserved hydrogen-bonded Trp-His pair. These residues are part of a conservedWDSLxH/N motif found in GmACP3 and its orthologs. The helix locations and the large hydrophobic cavity are more similar tomediumand long-chain acyl-ACPs than to other apo- and holo-ACP structures. Taken together, structural characterization along with bioinformatic analysis of nearby genes suggests that GmACP3 is involved in lipid A acylation, possibly by atypical long-chain hydroxy fatty acids, and potentially is involved in synthesis of secondary metabolites.

  17. Lights, camera and action: learning necrophilia in a psychiatry movie club.

    PubMed

    Kalra, Gurvinder S

    2013-04-01

    Kissed (1996) is a serious film that portrays the disturbing and taboo issue of necrophilia in a delicate and viewer friendly way. Being a rare paraphilia, it may sometimes be difficult to get necrophilia related literature or even understand this complex behavior. An interested person may have to rely on the few case reports from forensic journals or law books in order to understand what and how necrophiles do what they do! A movie club can be an interesting and novel way to learn various issues in medicine and psychiatry, including necrophilia. This paper discusses the use of this film in academic sessions in order to learn necrophilia.

  18. Results of First Outdoor Comparison Between Absolute Cavity Pyrgeometer (ACP) and Infrared Integrating Sphere (IRIS) Radiometer at PMOD (Presentation)

    SciTech Connect

    Reda, I.; Grobner, J.; Wacker, S.; Stoffel, T.

    2013-03-01

    The ACP and IRIS are developed to establish a world reference for calibrating pyrgeometers with traceability to SI units. The two radiometers are unwindowed with negligible spectral dependence, and traceable to SI units through the temperature scale (ITS-90). The first outdoor comparison between the two designs was held from January 28 to February 8, 2013 at the Physikalisch-Metorologisches Observatorium Davos (PMOD). The difference between the irradiance measured by ACP and that of IRIS was within 1 W/m2. A difference of 5 W/m2 was observed between the irradiance measured by ACP&IRIS and that of the interim World Infrared Standard Group (WISG).

  19. Club drugs: reasons for and consequences of use.

    PubMed

    Parks, Kathleen A; Kennedy, Cheryl L

    2004-09-01

    This preliminary descriptive study was designed to assess the reasons, primary contexts, and consequences (physical, psychological, lifestyle) of club drug use in a sample of young adults in a mid-size U.S. city. Fifty young adults (18 to 30 years old) reported on their use of club drugs (Ecstasy, GHB, ketamine, Rohypnol, methamphetamine, LSD) in face-to-face interviews that included quantitative and qualitative measures. Ecstasy was the most frequently used club drug followed by ketamine, LSD and methamphetamine. All of the participants reported using club drugs to "experiment" and most reported using these drugs to feel good and enhance social activities. Club drugs were frequently used at raves, in bars or clubs, and at home with friends. An average of 16 negative physical, psychological, and lifestyle consequences were reported for club drug use. Despite substantial negative consequences, participants perceived several positive consequences of regular recreational club drug use. These findings corroborate descriptions of club drug use in other countries (e.g., Australia, United Kingdom) and provide additional information on perceived positive consequences that users experience with club drug use. Further exploration of the reasons and positive consequences that are associated with use of each of the club drugs may provide important information on the growing trend in use of these drugs.

  20. Topics for Mathematics Clubs. Second Edition.

    ERIC Educational Resources Information Center

    Dalton, LeRoy C., Ed.; Snyder, Henry D., Ed.

    One of the main purposes of a mathematics club is to provide the opportunity for students to study exciting topics in mathematics not ordinarily discussed in the classroom. Each of the 10 chapters in this booklet is a collection of related subtopics. Each idea is presented and discussed; bibliographies then suggest in-depth reading. The chapters…

  1. Operations Course Icebreaker: Campus Club Cupcakes Exercise

    ERIC Educational Resources Information Center

    Snider, Brent; Southin, Nancy

    2016-01-01

    Campus Club Cupcakes is an in-class "introduction to operations management" experiential learning exercise which can be used within minutes of starting the course. After reading the one-page mini case, students are encouraged to meet each other and collaborate to determine if making and selling cupcakes to fellow business students would…

  2. Reflections from the Reading Detective Club

    ERIC Educational Resources Information Center

    Yee-Vignola, Denise

    2014-01-01

    This action research study explores how strategic conversations and Retrospective Miscue Analysis (RMA) influences beliefs, attitudes, and perceptions about reading, as well as reading proficiencies and strategies of my "readers in trouble." Creating a Reading Detective Club (Goodman, D. 1999) in my own classroom provided opportunities…

  3. Advice on Setting up a STEM Club

    ERIC Educational Resources Information Center

    Khan, Faisal

    2013-01-01

    Setting up a STEM club can be the most daunting item that one faces on a department's development plan. Coupled with all the other demands that exist within teaching and learning, teachers can be easily forgiven for pushing this task further and further into the school year until it eventually becomes one of next year's "to-do" items.…

  4. Digital clubbing: forms, associations and pathophysiology.

    PubMed

    Dubrey, Simon; Pal, Shrestha; Singh, Sarneet; Karagiannis, Georgios

    2016-07-01

    Among proposed mechanisms to explain digital clubbing, the release of cytokines, specifically vascular endothelial growth factor and platelet-derived growth factor, from aggregated platelets and megakaryocytes has emerged as the most likely explanation. This review describes these and other contributory processes.

  5. Dr. von Braun Visits Huntsville Boys Club

    NASA Technical Reports Server (NTRS)

    1961-01-01

    Dr. von Braun, Director of Marshall Space Flight Center (MSFC) and chairman of this year's United Givers Fund (UGF) drive at MSFC, takes time out from the problems of sending a man to the Moon to talk baseball with 11-year-old Randy Smith at the Huntsville Boys Club.

  6. Making a Computer Club, Making a Community.

    ERIC Educational Resources Information Center

    Gillingham, M.; Youniss, E.

    2000-01-01

    Describes the development of a computer club at an inner city elementary school in Chicago. Discusses the sense of community that grew; parent involvement; scaffold learning; self-control; community service; difficulties in creating a sustainable innovation; and possible future directions. (Contains 11 references.) (LRW)

  7. The Before and After School Clubs.

    ERIC Educational Resources Information Center

    Brountas, Maria

    1993-01-01

    Discusses the Before and After School Clubs program at Vine Street School in Bangor, Maine, which allows students to come to school 30 minutes early or stay 30 minutes late on alternate days to participate in learning activities of their own choice. (MDM)

  8. Horizons: A Mother-Daughter Mathematics Club.

    ERIC Educational Resources Information Center

    Boling, Kimberly B.; Larson, Carol Novillis

    2002-01-01

    Describes a successful mother/daughter math club started by a third grade teacher which is designed to help participants increase positive feelings about mathematics; further develop problem-solving skills, especially involving construction and spatial visualization tasks; and become familiar with women's contributions to the world of mathematics.…

  9. The Miami Boys Club Delinquency Prevention Program.

    ERIC Educational Resources Information Center

    George, Paul; Mooney, Patrick

    1986-01-01

    Describes an instructional rehabilitation program that targets hard-core male delinquents. Run by the Boys Clubs of Miami, in conjunction with the Circuit Court's Juvenile Division, the program presently serves 120 youngsters at a third of the cost of the state training schools. (MD)

  10. Transition metal HE`s - VII ACP. Progress report, August 1971--October 1971

    SciTech Connect

    Clink, G.L.

    1998-12-31

    Physical and physicochemical properties of hexaamminechromium III perchlorate (ACP) were investigated to determine its potentiality for HE and/or HE component application. Physicochemical properties obtained through investigation of isothermally aged ACP under conditions of various system and boundary restrictions (open and closed; 50 and 80 C; 0.65 and 0.85 g/cc) show the material to be substantially stable under these simulated isothermal storage conditions from a standpoint of infrared and DTA thermal pattern behavior and chemical analysis of aged residues. Spark sensitivity was 0.25 joules at 5 kv (by LASL type test) and impact sensitivity was about 23 and 14 cm on sandpaper (12A) and steel (12B), respectively.

  11. Effects of the addition of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on mechanical properties of luting and lining glass ionomer cement

    NASA Astrophysics Data System (ADS)

    Heravi, Farzin; Bagheri, Hossein; Rangrazi, Abdolrasoul; Mojtaba Zebarjad, Seyed

    2016-07-01

    Recently, the addition of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) into glass ionomer cements (GICs) has attracted interest due to its remineralization of teeth and its antibacterial effects. However, it should be investigated to ensure that the incorporation of CPP-ACP does not have significant adverse effects on its mechanical properties. The purpose of this study was to evaluate the effects of the addition of CPP-ACP on the mechanical properties of luting and lining GIC. The first step was to synthesize the CPP-ACP. Then the CPP-ACP at concentrations of 1%, 1.56% and 2% of CPP-ACP was added into a luting and lining GIC. GIC without CPP-ACP was used as a control group. The results revealed that the incorporation of CPP-ACP up to 1.56%(w/w) increased the flexural strength (29%), diametral tensile strength (36%) and microhardness (18%), followed by a reduction in these mechanical properties at 2%(w/w) CPP-ACP. The wear rate was significantly decreased (23%) in 1.56%(w/w) concentration of CPP-ACP and it was increased in 2%(w/w). Accordingly, the addition of 1.56%(w/w) CPP-ACP into luting and lining GIC had no adverse effect on the mechanical properties of luting and lining GIC and could be used in clinical practice.

  12. A 12-Week Assessment of the Treatment of White Spot Lesions with CPP-ACP Paste and/or Fluoride Varnish

    PubMed Central

    Güçlü, Zeynep Aslı; Alaçam, Alev

    2016-01-01

    This 12-week clinical study evaluated the impact of 10% CPP-ACP and 5% sodium fluoride varnish regimes on the regression of nonorthodontic white spot lesions (WSLs). The study included 21 children with 101 WSLs who were randomised into four treatment regimes: weekly clinical applications of fluoride varnish for the first month (FV); twice daily self-applications of CPP-ACP paste (CPP-ACP); weekly applications of fluoride varnish for the first month and twice daily self-applications of CPP-ACP paste (CPP-ACP-FV); and no intervention (control). All groups undertook a standard oral hygiene protocol and weekly consultation. Visual appraisals and laser fluorescence (LF) measurements were made in weeks one and twelve. The majority of WSLs in the control and FV groups exhibited no shift in appearance, whereas, in the CPP-ACP and CPP-ACP-FV groups, the lesions predominantly regressed. The visual and LF assessments indicated that the extent of remineralisation afforded by the treatments was of the following order: control ~ FV < CPP-ACP ~ CPP-ACP-FV. Self-applications of CPP-ACP paste as an adjunct to standard oral hygiene significantly improved the appearance and remineralisation of WSLs. No advantage was observed for the use of fluoride varnish as a supplement to either the standard or CPP-ACP-enhanced oral hygiene regimes. PMID:27843950

  13. Journal bearing

    DOEpatents

    Menke, John R.; Boeker, Gilbert F.

    1976-05-11

    1. An improved journal bearing comprising in combination a non-rotatable cylindrical bearing member having a first bearing surface, a rotatable cylindrical bearing member having a confronting second bearing surface having a plurality of bearing elements, a source of lubricant adjacent said bearing elements for supplying lubricant thereto, each bearing element consisting of a pair of elongated relatively shallowly depressed surfaces lying in a cylindrical surface co-axial with the non-depressed surface and diverging from one another in the direction of rotation and obliquely arranged with respect to the axis of rotation of said rotatable member to cause a flow of lubricant longitudinally along said depressed surfaces from their distal ends toward their proximal ends as said bearing members are rotated relative to one another, each depressed surface subtending a radial angle of less than 360.degree., and means for rotating said rotatable bearing member to cause the lubricant to flow across and along said depressed surfaces, the flow of lubricant being impeded by the non-depressed portions of said second bearing surface to cause an increase in the lubricant pressure.

  14. Effect of CPP-ACP paste on dental caries in primary teeth: a randomized trial.

    PubMed

    Sitthisettapong, T; Phantumvanit, P; Huebner, C; Derouen, T

    2012-09-01

    This clinical trial tested the effect of daily application of 10% w/v calcium phosphopeptide-amorphous calcium phosphate (CPP-ACP) paste for 1 yr when added to regular toothbrushing with fluoridated toothpaste to prevent dental caries in pre-school children. High-caries-risk children aged 2½ to 3½ yrs in a suburban area of central Thailand were assigned to receive either CPP-ACP (n = 150) or a placebo control (n = 146) in addition to fluoridated toothpaste. The International Caries Detection and Assessment System (ICDAS) was recorded at baseline, 6 mos, and 1 yr. At 1 yr, a significant increase in mean numbers of enamel and dentin caries lesions, as well as dmfs, was found in both groups (p < 0.001). No significant difference was observed between groups on these 3 outcome measures (p = 0.23, 0.84, and 0.91, respectively). The odds of enamel caries lesion transitions to a state of regression or stability, compared with progression from baseline, was also not different between groups [OR = 1.00, 95% CI (0.86, 1.17)]. This trial found that daily application of 10% w/v CPP-ACP paste on school days for 1 yr, when added to regular toothbrushing with a fluoride toothpaste, had no significant added effect in preventing caries in the primary dentition of these pre-school children (ClinicalTrials.gov number CT01 604109).

  15. Histochemical localization and characterization of AKP, ACP, NSE, and POD from cultured Apostichopus japonicus

    NASA Astrophysics Data System (ADS)

    Li, Jiye; Sun, Xiuqin; Zheng, Fengrong; Sun, Hushan

    2009-09-01

    We investigated the distribution of four enzymes involved in the immune response of Apostichopus japonicus. We collected samples of the tentacles, papillate podium, integument, respiratory tree, and digestive tract and stained them for acid phosphatase (ACP), alkaline phosphatase (AKP), non-specific esterase (NSE) and peroxidase (POD) activity. The distribution and content of ACP, AKP, NSE, and POD differed among the tissues. The coelomic epithelium of the tentacle, papillate podium, and integument and the mucous layer of respiratory tree were positive for ACP activity. The coelomic epithelium and cuticular layer of the tentacle, papillate podium, and integument and the mucous layer and tunica externa of the respiratory tree and digestive tract stained positive or weakly positive for AKP activity. Almost all the epithelial tissues stained positive, strongly positive, or very strongly positive for NSE activity. The cuticular layer of the tentacle and integument and the mucous layer, tunica submucosa, and tunica externa of the respiratory tree and digestive tract stained positive for POD activity. We hypothesize that these enzymes play a role in the immune response in A. japonicus.

  16. The influence of powdered coconut water (ACP-318®) in in vitro maturation of canine oocytes.

    PubMed

    Silva, A E F; Cavalcante, L F; Rodrigues, B A; Rodrigues, J L

    2010-12-01

    The objective of this study was to determine the influence of powdered coconut water (ACP-318(®)) diluted in high glucose (11.0 mM) TCM199 in the achievement of nuclear in vitro maturation (IVM) of canine oocytes. Cumulus oocyte complexes (COCs) (n = 632) were randomly allocated into three experimental groups named as group 1 (control group), group 2 (5% powdered coconut water) and group 3 (10% powdered coconut water). The percentage of meiotic resumption (MR) (GVBD to MII) was 39.1% (81/207), 50.2% (108/215) and 46.6% (98/210) for groups 1, 2 and 3 respectively (p < 0.05). There were no differences in MR rates among groups 2 and 3. The medium with ACP-318(®) slightly enhanced the nuclear maturation of canine oocytes when a comparison was established with rates of maturation exhibited by oocytes in the experimental group 1 without ACP-318(®) (p < 0.05). The results suggest that oocytes' nuclear morphology integrity and meiosis achievement were positively influenced when exposed to high glucose TCM199 supplemented with 5% powdered coconut water. Further investigation must be performed for a better understanding of powdered coconut water influence in cellular events during IVM of dog oocytes.

  17. The Joint Polar Satellite System (JPSS) Program's Algorithm Change Process (ACP): Past, Present and Future

    NASA Technical Reports Server (NTRS)

    Griffin, Ashley

    2017-01-01

    The Joint Polar Satellite System (JPSS) Program Office is the supporting organization for the Suomi National Polar Orbiting Partnership (S-NPP) and JPSS-1 satellites. S-NPP carries the following sensors: VIIRS, CrIS, ATMS, OMPS, and CERES with instruments that ultimately produce over 25 data products that cover the Earths weather, oceans, and atmosphere. A team of scientists and engineers from all over the United States document, monitor and fix errors in operational software code or documentation with the algorithm change process (ACP) to ensure the success of the S-NPP and JPSS 1 missions by maintaining quality and accuracy of the data products the scientific community relies on. This poster will outline the programs algorithm change process (ACP), identify the various users and scientific applications of our operational data products and highlight changes that have been made to the ACP to accommodate operating system upgrades to the JPSS programs Interface Data Processing Segment (IDPS), so that the program is ready for the transition to the 2017 JPSS-1 satellite mission and beyond.

  18. Creating a Health Journal

    MedlinePlus

    ... Health Resources Healthcare Management Working With Your Doctor Creating a Personal Health Journal (Health Diary) Creating a Personal Health Journal (Health Diary) Healthcare ManagementWorking ...

  19. The magazine of a sadomasochism club: the tie that binds.

    PubMed

    Houlberg, R

    1991-01-01

    The monthly magazine of a sadomasochism club was investigated as a means of describing important issues for club members. The magazine was selected for this exploratory study because it is: (a) The club's only recorded history; (b) the only repository of club members' writings and photographs; and (c) the only link to the club for about 15% of the membership who do not attend meetings or other club activities because they reside some distance from the club's two West Coast chapters. A descriptive content analysis was performed on 47 issues of the club's magazine, published between October 1983 and January 1988, and the results were combined with the findings of a December 1987 magazine readership survey completed by 44% of the 812 dues-paying club members. The author's nonparticipant observations of club programs are also reported. The results indicate the magazine's space is filled by seven subject categories: S/M media reviews (2% of space), S/M poetry (5%), S/M issues (10%), S/M "how-to" (12%), S/M photography (14%), fantasy and real S/M stories (17%), and organizational reports (40%).

  20. Breakfast Clubs: Starting the Day in a Positive Way

    PubMed Central

    Graham, Pamela Louise; Russo, Riccardo; Defeyter, Margaret Anne

    2015-01-01

    Breakfast clubs are widely promoted as having a beneficial impact on children’s behavior at the start of the school day, which can be conducive to their learning within the classroom. However, the few available studies that have considered the impact of breakfast club attendance on children’s behavior have yielded mixed results and no studies to date have directly observed children’s behavior within the breakfast club setting. Using a combination of real-time observation and filmed breakfast club footage, the aims of the current study were to: (1) devise a set of observational criteria appropriate for use in the breakfast club setting; (2) investigate the occurrence of both positive and negative behaviors. A sample of 30 children aged between 3 and 11 years were recruited from 3, opportunistically sampled primary school breakfast clubs in the North East of England, UK. The behaviors they displayed within the breakfast club setting on two separate days were observed and coded for subsequent analysis. Results of the investigation showed that children’s behavior could be classified into three positive and three negative behavioral categories. Using these categories to code children’s behavior as they engaged in breakfast club showed that children displayed more positive than negative behaviors within the breakfast club setting and this was the case regardless of the type of activity (i.e., quiet or boisterous) children were involved in. Findings are discussed in relation to breakfast club policy, implementation, and evaluation. PMID:26217653

  1. Developmental induction, purification, and further characterization of 12:0-ACP thioesterase from immature cotyledons of Umbellularia californica.

    PubMed

    Davies, H M; Anderson, L; Fan, C; Hawkins, D J

    1991-10-01

    The fatty acyl content of developing cotyledons of Umbellularia californica (California Bay) changes from a long-chain composition to a predominance of 10:0 and 12:0 in just 4-5 days at the beginning of an approximately 100-day period of medium-chain deposition. This striking change occurs at the earliest appearance of 12:0-acyl-carrier protein (ACP) thioesterase activity. The coincidence of these rapid events is consistent with the hypothesis that the enzyme plays a major role in medium-chain biosynthesis. The 12:0-ACP thioesterase has been substantially purified; enzyme activity consistently comigrates in chromatographic and electrophoretic systems with a protein or pair of proteins having an apparent molecular weight of approximately 34 kDa. A native molecular weight of approximately 42 kDa has been estimated by gel filtration chromatography, suggesting that the enzyme is a monomer. Affinity chromatography on immobilized ACP is a critical step in the purification procedure, and resolves the 12:0-ACP and 18:1-ACP thioesterases sufficiently to confirm that the medium-chain enzyme has negligible action on 18:1-ACP.

  2. Acyl-ACP thioesterases from macadamia (Macadamia tetraphylla) nuts: cloning, characterization and their impact on oil composition.

    PubMed

    Moreno-Pérez, Antonio J; Sánchez-García, Alicia; Salas, Joaquín J; Garcés, Rafael; Martínez-Force, Enrique

    2011-01-01

    The mechanisms by which macadamia nuts accumulate the unusual palmitoleic and asclepic acyl moieties, which constitute up to 20% of the fatty acids in some varieties, are still unknown. Acyl-acyl carrier protein (ACP) thioesterases (EC 3.1.2.14) are intraplastidial enzymes that terminate the synthesis of fatty acids in plants and that facilitate the export of the acyl moieties to the endoplasmic reticulum where they can be used in the production of glycerolipids. Here, we have investigated the possible role of acyl-ACP thioesterase activity in the composition of macadamia kernel oil. Accordingly, two acyl-ACP thioesterases were cloned from developing macadamia kernels, one of the FatA type and the other of the FatB type. These enzymes were heterologously expressed in Escherichia coli, and the recombinant thioesterases were purified, characterized kinetically and assayed with a variety of substrates, demonstrating the high specificity of macadamia FatA towards 16:1-ACP. Acyl-ACP thioesterase activity was also characterized in crude extracts from two different varieties of macadamia, Cate and Beaumont, which accumulate different amounts of n-7 fatty acids. The impact of acyl-ACP thioesterase activities on the oil composition of these kernels is discussed in the light of these results.

  3. Intravaginal artificial insemination in bitches using frozen/thawed semen after dilution in powdered coconut water (ACP-106c).

    PubMed

    Uchoa, D C; Silva, T F P; Mota Filho, A C; Silva, L D M

    2012-12-01

    The aim of this study was to evaluate powdered coconut water extender (ACP-106c; ACP Serviços Tecnológicos Ltda, ACP Biotecnologia, Fortaleza, Ceará, Brazil) as a diluent for freezing dog semen and the fertility after vaginal insemination of semen frozen therein. Ten ejaculates were collected from five dogs, evaluated fresh, diluted in ACP-106c, 10% egg yolk and 6% glycerol, cooled and frozen. In the first phase of the study, straws with frozen semen were thawed and immediately subjected to the same analysis as the fresh semen and, in addition, to Computer-Assisted Semen Analysis (CASA). In phase 2, 10 bitches that had been subjected to natural breeding during a preceding oestrous cycle were vaginally inseminated with thawed semen that had been re-diluted in ACP-106c. After thawing, a mean of 77% sperm motility was obtained through subjective analysis and 77.3% through CASA. Following artificial insemination, a 60% pregnancy rate was observed, resulting in a 50% parturition rate and a mean litter size of 3.4 (SEM 0.6), with 47.1% males and 52.9% females. ACP-106c can be successfully used for freezing canine semen, and vaginal deposition of such semen yields similar pregnancy rates to those reported in other studies.

  4. Why certain male grasshoppers have clubbed antennae?

    PubMed

    Dumas, Pascaline; Tetreau, Guillaume; Petit, Daniel

    2010-05-01

    The significance of clubbed antennae in grasshoppers was assessed by investigating the sensilla repertoire of 15 gomphocerine species. The influence of the diet type (graminivorous or polyphagous) and the apical thickening of antenna on the number of sensilla were tested. It appears that the antennal thickening has a stronger impact on the number of sensilla than the food mode. The species bearing clubbed antennae are globally low in olfactive and contact sensilla, maybe in relation with a more complex courtship, but are richer in mechanoreceptors, probably involved in the control of antenna movements. The food mode change from oligophagy to polyphagy is not associated to an increase in the number of olfactive or contact sensilla. In contrast, the high number of these sensilla in a monophagous grasshopper feeding on Ulex bushes is interpreted in the context of alkaloid detection.

  5. The Fuel Cell Powered Club Car Carryall

    NASA Technical Reports Server (NTRS)

    Eichenberg, Dennis J.

    2005-01-01

    The NASA Glenn Research Center initiated development of the Fuel Cell Powered Club Car Carryall as a way to reduce pollution in industrial settings, reduce fossil fuel consumption and reduce operating costs for transportation systems. The Club Car Carryall provides an inexpensive approach to advance the state of the art in electric vehicle technology in a practical application. The project transfers space technology to terrestrial use via non-traditional partners, and provides power system data valuable for future aeronautics and space applications. The work was done under the Hybrid Power Management (HPM) Program. The Carryall is a state of the art, dedicated, electric utility vehicle. Hydrogen powered proton exchange membrane (PEM) fuel cells are the primary power source. Ultracapacitors were used for energy storage as long life, maintenance free operation, and excellent low temperature performance is essential. Metal hydride hydrogen storage was used to store hydrogen in a safe and efficient low-pressure solid form. The report concludes that the Fuel Cell Powered Club Car Carryall can provide excellent performance, and that the implementation of fuel cells in conjunction with ultracapacitors in the power system can provide significant reliability and performance improvements.

  6. European journals on microbiology.

    PubMed

    Ronda, C; Vázquez, M

    1997-12-01

    A survey on the scientific journals dealing with microbiology published in Europe has been carried out. Eighteen European countries publish microbiological journals with the United Kingdom. Netherlands and Germany leading in number of journals on this specialty. Most of the European journals on microbiology are published bimonthly (27%), and English is the most common language used (54%). Most of these journals (86%) are included in some database, but only 36 (25%) are indexed in the six databases studied. Out of the 146 journals registered, 71 (49%), published in 11 European countries, are included in the 1995 Journal Citation Reports (ISI, Philadelphia).

  7. Identification of Genes Required for Secretion of the Francisella Oxidative Burst-Inhibiting Acid Phosphatase AcpA

    PubMed Central

    Hoang, Ky Van; Chen, Carolyn G.; Koopman, Jacob; Moshiri, Jasmine; Adcox, Haley E.; Gunn, John S.

    2016-01-01

    Francisella tularensis is a Tier 1 bioterror threat and the intracellular pathogen responsible for tularemia in humans and animals. Upon entry into the host, Francisella uses multiple mechanisms to evade killing. Our previous studies have shown that after entering its primary cellular host, the macrophage, Francisella immediately suppresses the oxidative burst by secreting a series of acid phosphatases including AcpA-B-C and HapA, thereby evading the innate immune response of the macrophage and enhancing survival and further infection. However, the mechanism of acid phosphatase secretion by Francisella is still unknown. In this study, we screened for genes required for AcpA secretion in Francisella. We initially demonstrated that the known secretion systems, the putative Francisella-pathogenicity island (FPI)-encoded Type VI secretion system and the Type IV pili, do not secrete AcpA. Using random transposon mutagenesis in conjunction with ELISA, Western blotting and acid phosphatase enzymatic assays, a transposon library of 5450 mutants was screened for strains with a minimum 1.5-fold decrease in secreted (culture supernatant) AcpA, but no defect in cytosolic AcpA. Three mutants with decreased supernatant AcpA were identified. The transposon insertion sites of these mutants were revealed by direct genomic sequencing or inverse-PCR and sequencing. One of these mutants has a severe defect in AcpA secretion (at least 85% decrease) and is a predicted hypothetical inner membrane protein. Interestingly, this mutant also affected the secretion of the FPI-encoded protein, VgrG. Thus, this screen identified novel protein secretion factors involved in the subversion of host defenses. PMID:27199935

  8. Remineralizing efficacy of a CPP-ACP cream on enamel caries lesions in situ.

    PubMed

    Meyer-Lueckel, Hendrik; Wierichs, Richard J; Schellwien, Timo; Paris, Sebastian

    2015-01-01

    The aim of this double-blind, randomized, cross-over in situ study was to compare the remineralizing effects induced by the application of casein phosphopeptide-stabilized amorphous calcium phosphate complexes (CPP-ACP)-containing cream (without fluoride) after the use of fluoride toothpaste with the prolonged use of fluoride toothpaste on enamel caries lesions in situ. During each of three experimental legs of 4 weeks, 13 participants wore intra-oral mandibular appliances with 8 pre-demineralized bovine enamel specimens in the vestibular flanges mimicking either 'easily cleanable' or 'proximal' surfaces (n = 312). The three randomly allocated treatments were as follows: (1) application of CPP-ACP-containing cream (GC Tooth Mouse, non-fluoride) after the use of fluoride toothpaste (1,400 ppm NaF; TM), (2) prolonged application of fluoride toothpaste (1,400 ppm NaF; positive control, PC) and (3) prolonged application of fluoride-free toothpaste (negative control, NC). Additionally, one of each of the two flanges was brushed twice daily with the respective toothpaste. The differences in integrated mineral loss as assessed by transversal microradiography were calculated between values before and after the in situ period. Changes in mineral loss were analysed for those pairs of subgroups differing in only one of the three factors (intervention, brushing and position). The PC treatment induced a significantly higher mineral gain compared with the TM and NC treatments. No significant differences between TM and NC for both positions were observed. In conclusion, the additional use of a CPP-ACP-containing cream seems to be less efficacious in remineralizing caries lesions than the prolonged application of fluoride toothpaste.

  9. Combining CPP-ACP with fluoride: a synergistic remineralization potential of artificially demineralized enamel or not?

    NASA Astrophysics Data System (ADS)

    El-Sayad, I. I.; Sakr, A. K.; Badr, Y. A.

    2008-08-01

    Background and objective: Minimal intervention dentistry (MID) calls for early detection and remineralization of initial demineralization. Laser fluorescence is efficient in detecting changes in mineral tooth content. Recaldent is a product of casein phosphopeptide-amorphous calcium phosphate (CPP- ACP) which delivers calcium and phosphate ions to enamel. A new product which also contains fluoride is launched in United States. The remineralizing potential of CPP- ACP per se, or when combined with 0.22% Fl supplied in an oral care gel on artificially demineralised enamel using laser fluorescence was investigated. Methods: Fifteen sound human molars were selected. Mesial surfaces were tested using He-Cd laser beam at 441.5nm with 18mW power as excitation source on a suitable set-up based on Spex 750 M monochromator provided with PMT for detection of collected auto-fluorescence from sound enamel. Mesial surfaces were subjected to demineralization for ten days. The spectra from demineralized enamel were measured. Teeth were then divided according to the remineralizing regimen into three groups: group I recaldent per se, group II recaldent combined with fluoride gel and group III artificial saliva as a positive control. After following these protocols for three weeks, the spectra from remineralized enamel from the three groups were measured. The spectra of enamel auto-fluorescence were recorded and normalized to peak intensity at about 540 nm to compare between spectra from sound, demineralized and remineralized enamel surfaces. Results: A slight red shift was noticed in spectra from demineralized enamel, while a blue shift may occur in remineralized enamel. Group II showed the highest remineralizing potential. Conclusions: Combining fluoride with CPP-ACP had a synergistic effect on enamel remineralization. In addition, laser auto-fluorescence is an accurate technique for assessment of changes in tooth enamel minerals.

  10. ACP1 Genetic Polymorphism and Coronary Artery Disease: Evidence of Effects on Clinical Parameters of Cardiac Function

    PubMed Central

    Gloria-Bottini, Fulvia; Banci, Maria; Saccucci, Patrizia; Nardi, Paolo; Scognamiglio, Mattia; Papetti, Federica; Adanti, Sara; Magrini, Andrea; Pellegrino, Antonio; Bottini, Egidio; Chiariello, Luigi

    2013-01-01

    Background Kinases and phosphatases have an important role in the susceptibility and clinical variability of cardiac diseases. We have recently reported an association between a phosphoprotein phosphatase controlled by Acid Phosphatase locus 1 (ACP1), and Coronary artery disease (CAD) suggesting an effect on the susceptibility to this disease. In the present note we have investigated a possible role of ACP1 in the variability of clinical parameters of cardiac function. Methods We have studied 345 subjects admitted to Valmontone Hospital for cardiovascular diseases: 202 subjects with CAD and 143 without CAD, 53 subjects admitted to Cardiac Surgery Division of Tor Vergata University were also considered. Results In diabetic patients with CAD there is a significant negative association between Left ventricular ejection fraction (LVEF) and ACP1 S isoform concentration. Genotypes with high S isoform concentration show a lower value of LVEF as compared to genotypes with low S isoform concentration. We have also found a significant positive association between cNYHA class and ACP1 S isoform. After surgical intervention, in subjects with high S isoform concentration the decrease of LVEF is more marked as compared to subjects with low S isoform concentration. Overall these observations indicate that high S isoform activity has negative effects on cardiac function. The observation in patients undergoing cardiac surgery confirms the negative association between high S isoform activity and LVEF. Conclusions The present study suggests that ACP1 influences both susceptibility to CAD and clinical manifestations of the disease.

  11. Short-term storage of canine preantral ovarian follicles using a powdered coconut water (ACP)-based medium.

    PubMed

    Lima, G L; Costa, L L M; Cavalcanti, D M L P; Rodrigues, C M F; Freire, F A M; Fontenele-Neto, J D; Silva, A R

    2010-07-01

    The objective was to investigate the use of powdered coconut water (ACP)-based medium for short-term preservation of canine preantral follicles. Pairs of ovaries from mongrel bitches (n=9) were divided into fragments. One ovarian fragment, treated as a fresh control, was immediately fixed for histological analysis, whereas the other six ovarian fragments were stored either in phosphate-buffered saline (PBS; control group) or ACP medium in isothermal Styrofoam boxes containing biological ice packs. The boxes were sealed and opened only after 12, 24, or 36h. After opening each box, the ovarian fragments were submitted to histological analysis. In total, 12,302 preantral follicles were evaluated, with 64.5% primordial, 33.3% primary, and 2.3% secondary follicles. There were multiple oocytes in 1.3% of the follicles analyzed. At 24h, ACP was more efficient in preserving follicular morphology than PBS (P<0.05). Compared with the fresh control group, a significant reduction in the percentage of morphologically normal ovarian follicles was observed for PBS, starting at 24h; however, the decline started only at 36h for the ACP medium. During the experiment, the temperature inside the isothermal boxes increased from 3 to 9 degrees C (P<0.05), despite a constant room temperature. In conclusion, powdered coconut water (ACP) was an appropriate medium for short-term storage of canine preantral ovarian follicles.

  12. Acyl-ACP thioesterases from Camelina sativa: cloning, enzymatic characterization and implication in seed oil fatty acid composition.

    PubMed

    Rodríguez-Rodríguez, Manuel Fernando; Salas, Joaquín J; Garcés, Rafael; Martínez-Force, Enrique

    2014-11-01

    Acyl-acyl carrier protein (ACP) thioesterases are intraplastidial enzymes that terminate de novo fatty acid biosynthesis in the plastids of higher plants by hydrolyzing the thioester bond between ACP and the fatty acid synthesized. Free fatty acids are then esterified with coenzyme A prior to being incorporated into the glycerolipids synthesized through the eukaryotic pathway. Acyl-ACP thioesterases belong to the TE14 family of thioester-active enzymes and can be classified as FatAs and FatBs, which differ in their amino acid sequence and substrate specificity. Here, the FatA and FatB thioesterases from Camelina sativa seeds, a crop of interest in plant biotechnology, were cloned, sequenced and characterized. The mature proteins encoded by these genes were characterized biochemically after they were heterologously expressed in Escherichia coli and purified. C. sativa contained three different alleles of both the FatA and FatB genes. These genes were expressed most strongly in expanding tissues in which lipids are very actively synthesized, such as developing seed endosperm. The CsFatA enzyme displayed high catalytic efficiency on oleoyl-ACP and CsFatB acted efficiently on palmitoyl-ACP. The contribution of these two enzymes to the synthesis of C. sativa oil was discussed in the light of these results.

  13. Health promotion activities of sports clubs and coaches, and health and health behaviours in youth participating in sports clubs: the Health Promoting Sports Club study

    PubMed Central

    Kokko, Sami; Selänne, Harri; Alanko, Lauri; Heinonen, Olli J; Korpelainen, Raija; Savonen, Kai; Vasankari, Tommi; Kannas, Lasse; Kujala, Urho M; Aira, Tuula; Villberg, Jari; Parkkari, Jari

    2015-01-01

    Introduction Sports clubs form a potential setting for health promotion, but the research is limited. The aim of the Health Promoting Sports Club (HPSC) study was to elucidate the current health promotion activities of youth sports clubs and coaches, and to investigate the health behaviours and health status of youth participating in sports clubs compared to non-participants. Methods and analysis The study design employs cross-sectional multilevel and multimethod research with aspirations to a prospective cohort study in the next phase. The setting-based variables at sports clubs and coaching levels, and health behaviour variables at the individual level, are investigated using surveys; and total levels of physical activity are assessed using objective accelerometer measurements. Health status variables will be measured by preparticipation screening. The health promotion activity of sports clubs (n=154) is evaluated by club officials (n=313) and coaches (n=281). Coaches and young athletes aged 14–16 (n=759) years evaluate the coaches’ health promotion activity. The survey of the adolescents’ health behaviours consist of two data sets—the first is on their health behaviours and the second is on musculoskeletal complaints and injuries. Data are collected via sports clubs (759 participants) and schools 1650 (665 participants and 983 non-participants). 591 (418 athletes and 173 non-athletes) youth, have already participated in preparticipation screening. Screening consists of detailed personal medical history, electrocardiography, flow-volume spirometry, basic laboratory analyses and health status screening, including posture, muscle balance, and static and dynamic postural control tests, conducted by sports and exercise medicine specialists. Ethics and dissemination The HPSC study is carried out conforming with the declaration of Helsinki. Ethical approval was received from the Ethics Committee of Health Care District of Central Finland. The HPSC study is

  14. Adolescent Multilinguals' Engagement with Religion in a Book Club

    ERIC Educational Resources Information Center

    Choi, Jayoung; Tinker Sachs, Gertrude

    2017-01-01

    The study examines four adolescent multilinguals' engagement with religion, as well as outcomes of that engagement, in an out-of-school book club. The qualitative analysis of participants' talk in book club meetings, writing responses, and individual interviews revealed that multilinguals tap into their religious knowledge and identities in making…

  15. Resources for Teachers Starting a Planet Protector’s Club

    EPA Pesticide Factsheets

    EPA’s Planet Protector activities are a great way to get student’s interested in reducing, reusing and recycling. Use the activities to launch an ongoing club with our club factsheet, membership badge, activity calendar, and certificate of completion.

  16. Stalemate: Girls and a Mixed-Gender Chess Club.

    ERIC Educational Resources Information Center

    Galitis, Ingrid

    2002-01-01

    Observed and conducted discussions with female members of an elementary-level, mixed-gender, Australian chess club to investigate why girls left and boys came to dominate the club. Results indicated that both home values and schooling transmitted and reinforced inequalities between the sexes, though in more subtle and less overt forms than in the…

  17. Science Notes: The Clubbers' Guide--School Biology Clubs

    ERIC Educational Resources Information Center

    Howarth, Sue

    2014-01-01

    The STEM team at the University of Worcester support STEM activities in schools in Herefordshire and Worcestershire. Part of this help includes suggesting activities for STEM clubs. As the biologist on the team author, Sue Howarth was asked by teachers for ideas to use in biology clubs. This article was prompted by feedback that these ideas might…

  18. School Nurse Book Clubs: An Innovative Strategy for Lifelong Learning

    ERIC Educational Resources Information Center

    Greenawald, Deborah A.; Adams, Theresa M.

    2008-01-01

    Recognizing the ongoing need for continuing education for school nurses, the authors discuss the use of school nurse book clubs as an innovative lifelong-learning strategy. Current research supports the use of literature in nursing education. This article discusses the benefits of book club participation for school nurses and includes suggested…

  19. Contextual view to northnorthwest of Burton Park Club House and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view to north-northwest of Burton Park Club House and Amphitheater (90 mm lens). View taken from top of steps visible in previous photo. - Burton Park, Club House & Amphitheater, Adjacent ot south end of Chestnut Avenue, San Carlos, San Mateo County, CA

  20. Contextual view to northwest of Burton Park Club House and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view to northwest of Burton Park Club House and Amphitheater. Gable-roofed building at right is barn housing maintenance equipment for the park. Adobe wall with pilasters forms backdrop for amphitheater stage (135mm lens). - Burton Park, Club House & Amphitheater, Adjacent ot south end of Chestnut Avenue, San Carlos, San Mateo County, CA

  1. 27 CFR 31.41 - Clubs or similar organizations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... organizations. 31.41 Section 31.41 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... Certain Organizations, Agencies, and Persons § 31.41 Clubs or similar organizations. (a) Subject to paragraph (b) of this section, a club or similar organization is a dealer for purposes of this part if...

  2. Learning Masculinities in a Japanese High School Rugby Club

    ERIC Educational Resources Information Center

    Light, Richard

    2008-01-01

    This paper draws on research conducted on a Tokyo high school rugby club to explore diversity in the masculinities formed through membership in the club. Based on the premise that particular forms of masculinity are expressed and learnt through ways of playing (game style) and the attendant regimes of training, it examines the expression and…

  3. Interior, main room , Burton Park Club House, view to ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Interior, main room , Burton Park Club House, view to south from north end door (90mm lens). Front doors visible at left, fireplace at right, while kingpost trusses supports the roof. - Burton Park, Club House & Amphitheater, Adjacent ot south end of Chestnut Avenue, San Carlos, San Mateo County, CA

  4. Interior, main room, Burton Park Club House, view to north ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Interior, main room, Burton Park Club House, view to north (90mm lens). Fireplace at left, kitchen and restroom are through open doorway visible at right side of opposite end wall. - Burton Park, Club House & Amphitheater, Adjacent ot south end of Chestnut Avenue, San Carlos, San Mateo County, CA

  5. Teaching the Women's Club Movement in United States History.

    ERIC Educational Resources Information Center

    Woyshner, Christine

    2002-01-01

    Focuses on teaching a U.S. history course to secondary school students about the women's club movement which began in the last quarter of the nineteenth century. Explores five key topic areas involving theoretical frameworks, community activities of the women, and skill development due to club involvement. (CMK)

  6. Tips for Organizing an Educational Agricultural Commodity Trading Club

    ERIC Educational Resources Information Center

    Yost, John

    2011-01-01

    Educational commodity marketing clubs have been an effective tool for producers to develop their grain and livestock marketing skills. These groups are further enhanced when the participants engage in "actual trading" versus "paper trading" techniques. When a club chooses to try actual trading, it becomes more complicated than pooling monies…

  7. 11. Photocopy of Photograph (Courtesy of the Detroit Hockey Club, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Photocopy of Photograph (Courtesy of the Detroit Hockey Club, Detroit, Michigan). GROUNDBREAKING FOR ADDITION, JUNE 23, 1965. Left Sid Abel, Genral Manager of the Detroit Hockey Club Center - Jerome Cavanaugh, Mayor, City of Detroit Right - Nick Landis, General Manager of the Olympia Stadium - Olympia Arena, 5920 Grand River Avenue, Detroit, MI

  8. After-Hours Science: Teaching Science with a Club.

    ERIC Educational Resources Information Center

    Dyreng, Ivan

    1984-01-01

    Describes Salt Lake City's (Utah) East High School science club, recognized by the National Science Teachers Association's Search for Excellence in Science Education project as an outstanding science program. Unique aspects of the club's activities, instructional strategies, and other areas are discussed. (BC)

  9. Next Chapter Book Club: What a Novel Idea

    ERIC Educational Resources Information Center

    Fish, Tom; Graff, Vicki

    2006-01-01

    In this article, the authors discuss a unique program of The Ohio State University's Nisonger Center--the Next Chapter Book Club (NCBC). The NCBC promotes literacy learning, community inclusion, and social connectedness for adolescents and adults with intellectual disabilities. Developed in 2002, the program has expanded from two clubs in…

  10. Discover 4-H Clubs: The Essential Resource for 4-H

    ERIC Educational Resources Information Center

    MacArthur, Stacey; Nelson, Cindy; Brower, Naomi; Memmott, Margie; Peterson, Gaelynn

    2016-01-01

    Obstacles facing new 4-H volunteers include time constraints and difficulty finding project-specific information, resources, and opportunities available for club members. As a solution to these obstacles and an aid for assisting volunteers in becoming confident in delivering information to youth, content experts produced Discover 4-H Clubs, a…

  11. View of the yacht club facing east. The new deck ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of the yacht club facing east. The new deck and the avila pier are on the right and the harbor storage and restrooms are on the left. - San Luis Yacht Club, Avila Pier, South of Front Street, Avila Beach, San Luis Obispo County, CA

  12. View of the yacht club from avila pier, facing west ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of the yacht club from avila pier, facing west northwest. The main entry is to the right and the more recent deck addition is to the left. - San Luis Yacht Club, Avila Pier, South of Front Street, Avila Beach, San Luis Obispo County, CA

  13. View of the yacht club facing north. The beach is ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of the yacht club facing north. The beach is in the foreground, the pier to the right. The painted octagonal window is above the deck. Avila's Front Street is at the rear of the building. - San Luis Yacht Club, Avila Pier, South of Front Street, Avila Beach, San Luis Obispo County, CA

  14. [Fourcroy and pharmaceutical journals].

    PubMed

    Bonnemain, Bruno

    2011-04-01

    Cadet de Gassicourt wrote a brief Eloge of Fourcroy in January 1810 as he died in December of 1809. Fourcroy had a major role concerning the new ideas on the place of pharmacy at the beginning of the 19th century. Fourcroy has had a key influence for the start of several pharmaceutical journals that wanted to emphasize the link between the new chemistry and pharmacy. None of these journals created with him will survive and one has to wait for 1909 to see the creation, without Fourcroy, of a new pharmaceutical journal, the "Journal de Pharmacie" that will become "Journal de Pharmacie et des Sciences accessoires", then "Journal de Pharmacie et de Chimie", before taking the name of"Annales Pharmaceutiques Françaises", the present official journal of the French Academy of Pharmacy. In spite of the essential role of Fourcroy at the start of pharmaceutical journals, Cadet did not even mention it in his Eloge of 1810.

  15. Providing medical marijuana: the importance of cannabis clubs.

    PubMed

    Feldman, H W; Mandel, J

    1998-01-01

    In 1996, shortly after the San Francisco Cannabis Club was raided and (temporarily) closed by state authorities, the authors conducted an ethnographic study by interviewing selected former members to ascertain how they had benefited from the use of medical marijuana and how they had utilized the clubs. Interviews were augmented by participant observation techniques. Respondents reported highly positive health benefits from marijuana itself, and underscored even greater benefits from the social aspects of the clubs, which they described as providing important emotional supports. As such, cannabis clubs serve as crucial support mechanisms/groups for people with a wide variety of serious illnesses and conditions. The authors concluded that of the various methods so far proposed, the cannabis clubs afford the best therapeutic setting for providing medical cannabis and for offering a healing environment composed of like-minded, sympathetic friends.

  16. Scientific Journalism in Armenia

    NASA Astrophysics Data System (ADS)

    Farmanyan, S. V.; Mickaelian, A. M.

    2015-07-01

    In the present study, the problems of scientific journalism and activities of Armenian science journalists are presented. Scientific journalism in the world, forms of its activities, Armenian Astronomical Society (ArAS) press-releases and their subjects, ArAS website "Mass Media News" section, annual and monthly calendars of astronomical events, and "Astghagitak" online journal are described. Most interesting astronomical subjects involved in scientific journalism, reasons for non-satisfactory science outreach and possible solutions are discussed.

  17. Favoring the birth of female puppies after artificial insemination using chilled semen diluted with powdered coconut water (ACP-106c).

    PubMed

    Uchoa, Daniel Couto; da Silva, Ticiana Franco Pereira; Cardoso, Janaína de Fátima Saraiva; Mota Filho, Antônio Cavalcante; Jucá, Ricardo Parente; Silva, Alexandre Rodrigues; da Silva, Lúcia Daniel Machado

    2012-06-01

    The objective was to determine the effect of powdered coconut water extender (ACP-106c) on the proportion of female puppies born. Twenty French Bulldog bitches were subjected to natural mating (NM) and, during the subsequent two estrus periods, were bred by intravaginal artificial insemination (AI), using chilled semen (from the same males) diluted in Tris-egg yolk (AI-Tris) or ACP-106c (AI-ACP-106c). Fresh semen was cooled to 5 °C and maintained at that temperature for 6 h, rewarmed (37 °C for 30 s), and used for AI. Pregnancy and whelping rates following NM were both 100% and were both 90.0% following AI with either extender. Litter size (mean ± SD) was 5.4 ±1.1, 4.7 ± 2.0, and 5.1 ± 2.0 (P > 0.05) for NM, AI-Tris, and AI-ACP-106c, respectively. Furthermore, for these groups, the number of female vs. male puppies born were 2.6 ± 0.6 vs. 2.8 ± 1.0, 2.2 ± 1.0 vs. 2.5 ± 1.1, and 3.4 ± 1.6 vs. 1.8 ± 1.2 (P < 0.05 for AI-ACP-106c only). In conclusion, our hypothesis was supported; AI of semen in ACP-106c extender resulted in a significantly higher proportion of female puppies. Furthermore, this extender yielded acceptable litter size and rates of pregnancy and whelping.

  18. The Journal Synthesizing Activity.

    ERIC Educational Resources Information Center

    Garber, Zev

    The journal synthesizing activity is intended to combine aspects of the formal essay with that of a diary. Activities associated with lecture topics are written up as short journal entries of approximately five typewritten pages and are turned in during the weekly class session at which the related topic is being discussed. The journal project…

  19. Club Drug Use among Young Adults Frequenting Dance Clubs and Other Social Venues in New York City

    ERIC Educational Resources Information Center

    Parsons, Jeffrey T.; Halkitis, Perry N.; Bimbi, David S.

    2006-01-01

    A convenience sample of young adults (ages 18-25) in New York City was recruited to complete anonymous surveys in social venues (either dance clubs or other social settings, such as coffee shops and university "hangouts") regarding their use of "club drugs" (e.g., MDMA/Ecstasy, GHB, ketamine, crystal methamphetamine, cocaine,…

  20. Why Children Join and Stay in Sports Clubs: Case Studies in Australian, French and German Swimming Clubs

    ERIC Educational Resources Information Center

    Light, Richard L.; Harvey, Stephen; Memmert, Daniel

    2013-01-01

    This article builds upon research on youth sport clubs conducted from a socio-cultural perspective by reporting on a study that inquired into the reasons why children aged 9-12 joined swimming clubs in France, Germany and Australia. Comprising three case studies it employed a mixed method approach with results considered within the framework of…

  1. A recent intermezzo at the Ribosome Club

    PubMed Central

    Pavlov, Michael Y.; Liljas, Anders

    2017-01-01

    Two sets of ribosome structures have recently led to two different interpretations of what limits the accuracy of codon translation by transfer RNAs. In this review, inspired by this intermezzo at the Ribosome Club, we briefly discuss accuracy amplification by energy driven proofreading and its implementation in genetic code translation. We further discuss general ways by which the monitoring bases of 16S rRNA may enhance the ultimate accuracy (d-values) and how the codon translation accuracy is reduced by the actions of Mg2+ ions and the presence of error inducing aminoglycoside antibiotics. We demonstrate that complete freezing-in of cognate-like tautomeric states of ribosome-bound nucleotide bases in transfer RNA or messenger RNA is not compatible with recent experiments on initial codon selection by transfer RNA in ternary complex with elongation factor Tu and GTP. From these considerations, we suggest that the sets of 30S subunit structures from the Ramakrishnan group and 70S structures from the Yusupov/Yusupova group may, after all, reflect two sides of the same coin and how the structurally based intermezzo at the Ribosome Club may be resolved simply by taking the dynamic aspects of ribosome function into account. This article is part of the themed issue ‘Perspectives on the ribosome’. PMID:28138071

  2. A recent intermezzo at the Ribosome Club.

    PubMed

    Pavlov, Michael Y; Liljas, Anders; Ehrenberg, Måns

    2017-03-19

    Two sets of ribosome structures have recently led to two different interpretations of what limits the accuracy of codon translation by transfer RNAs. In this review, inspired by this intermezzo at the Ribosome Club, we briefly discuss accuracy amplification by energy driven proofreading and its implementation in genetic code translation. We further discuss general ways by which the monitoring bases of 16S rRNA may enhance the ultimate accuracy (d-values) and how the codon translation accuracy is reduced by the actions of Mg(2+) ions and the presence of error inducing aminoglycoside antibiotics. We demonstrate that complete freezing-in of cognate-like tautomeric states of ribosome-bound nucleotide bases in transfer RNA or messenger RNA is not compatible with recent experiments on initial codon selection by transfer RNA in ternary complex with elongation factor Tu and GTP. From these considerations, we suggest that the sets of 30S subunit structures from the Ramakrishnan group and 70S structures from the Yusupov/Yusupova group may, after all, reflect two sides of the same coin and how the structurally based intermezzo at the Ribosome Club may be resolved simply by taking the dynamic aspects of ribosome function into account.This article is part of the themed issue 'Perspectives on the ribosome'.

  3. Visual Double Stars - St. Mary's High School Astronomy Club

    NASA Astrophysics Data System (ADS)

    Bensel, Holly; Tran, Thanh; Hicks, Sean; He, Yifan; Moczygemba, Mitchell; Shi, Yuqi; Sternenberg, Leah; Watson, Kaycia; Rooney, Kieran; Birmingham, Paige; You, Ruiyang

    2017-01-01

    The St. Mary’s School Astronomy Club is working towards measuring positions and angles of relatively unstudied visual binary stars. We are starting with confirming prior results we obtained at the Pine Mountain Observatory Summer Science Research Workshop in 2009 - 2012 on ARY 52 (Frey et al. 2009, JDSO), Iota Bootis (Bensel et al. 2009, JDSO), and Mizar (Bensel et al. 2009, JDSO). We are also comparing our results with those published in the Washington Double Star Catalog (Mason 2009). We are using Pine Mountain Observatory’s remote imaging 14-inch Meade Schmidt-Cassegrain telescope equipped with a CCD camera operated by Scott Fisher at the University of Oregon and local astronomer Sean Curry’s 12.5" PlaneWave CDK telescope. We are practicing using tools such as astrometry.net and DS9 software to measure positions and angles on known double stars with well established values before attempting new measurements. Our next project will be to study “neglected visual double stars,” lesser studied double stars with fainter magnitudes. (A neglected double star is one that has not been observed extensively or recently.)Double star analysis is relatively straight forward and can be performed with equipment available to most high schools.Educational outcomes include instrument setup, orientation, instruction, observations, analysis, presentation of data, and writing up findings for publication. Accurate recording of data is a useful and important life skill for all students to learn. Another important life skill is learning to work together to accomplish a specific goal. This project allows novice and experienced observers to work hand-in-hand to accomplish a specific goal, such as the publishing of a research paper in the Journal of Double Star Observations.

  4. How to Rank Journals

    PubMed Central

    Bradshaw, Corey J. A.; Brook, Barry W.

    2016-01-01

    There are now many methods available to assess the relative citation performance of peer-reviewed journals. Regardless of their individual faults and advantages, citation-based metrics are used by researchers to maximize the citation potential of their articles, and by employers to rank academic track records. The absolute value of any particular index is arguably meaningless unless compared to other journals, and different metrics result in divergent rankings. To provide a simple yet more objective way to rank journals within and among disciplines, we developed a κ-resampled composite journal rank incorporating five popular citation indices: Impact Factor, Immediacy Index, Source-Normalized Impact Per Paper, SCImago Journal Rank and Google 5-year h-index; this approach provides an index of relative rank uncertainty. We applied the approach to six sample sets of scientific journals from Ecology (n = 100 journals), Medicine (n = 100), Multidisciplinary (n = 50); Ecology + Multidisciplinary (n = 25), Obstetrics & Gynaecology (n = 25) and Marine Biology & Fisheries (n = 25). We then cross-compared the κ-resampled ranking for the Ecology + Multidisciplinary journal set to the results of a survey of 188 publishing ecologists who were asked to rank the same journals, and found a 0.68–0.84 Spearman’s ρ correlation between the two rankings datasets. Our composite index approach therefore approximates relative journal reputation, at least for that discipline. Agglomerative and divisive clustering and multi-dimensional scaling techniques applied to the Ecology + Multidisciplinary journal set identified specific clusters of similarly ranked journals, with only Nature & Science separating out from the others. When comparing a selection of journals within or among disciplines, we recommend collecting multiple citation-based metrics for a sample of relevant and realistic journals to calculate the composite rankings and their relative uncertainty windows. PMID:26930052

  5. How to Rank Journals.

    PubMed

    Bradshaw, Corey J A; Brook, Barry W

    2016-01-01

    There are now many methods available to assess the relative citation performance of peer-reviewed journals. Regardless of their individual faults and advantages, citation-based metrics are used by researchers to maximize the citation potential of their articles, and by employers to rank academic track records. The absolute value of any particular index is arguably meaningless unless compared to other journals, and different metrics result in divergent rankings. To provide a simple yet more objective way to rank journals within and among disciplines, we developed a κ-resampled composite journal rank incorporating five popular citation indices: Impact Factor, Immediacy Index, Source-Normalized Impact Per Paper, SCImago Journal Rank and Google 5-year h-index; this approach provides an index of relative rank uncertainty. We applied the approach to six sample sets of scientific journals from Ecology (n = 100 journals), Medicine (n = 100), Multidisciplinary (n = 50); Ecology + Multidisciplinary (n = 25), Obstetrics & Gynaecology (n = 25) and Marine Biology & Fisheries (n = 25). We then cross-compared the κ-resampled ranking for the Ecology + Multidisciplinary journal set to the results of a survey of 188 publishing ecologists who were asked to rank the same journals, and found a 0.68-0.84 Spearman's ρ correlation between the two rankings datasets. Our composite index approach therefore approximates relative journal reputation, at least for that discipline. Agglomerative and divisive clustering and multi-dimensional scaling techniques applied to the Ecology + Multidisciplinary journal set identified specific clusters of similarly ranked journals, with only Nature & Science separating out from the others. When comparing a selection of journals within or among disciplines, we recommend collecting multiple citation-based metrics for a sample of relevant and realistic journals to calculate the composite rankings and their relative uncertainty windows.

  6. Promoting undergraduate involvement through the University of Arizona Astronomy Club

    NASA Astrophysics Data System (ADS)

    McGraw, Allison M.; Austin, Carmen; Noyes, Matthew; Calahan, Jenny; Lautenbach, Jennifer; Henrici, Andrew; Ryleigh Fitzpatrick, M.; Shirley, Yancy L.

    2016-01-01

    The University of Arizona Astronomy Club is devoted to undergraduate success in astronomy, physics, planetary sciences and many other related fields. The club promotes many undergraduate opportunities; research projects, participating in telescope observational runs, sponsoring conference attendance as well as several public outreach opportunities. Research projects involving exoplanet transit observations and radio observations of cold molecular clouds allow undergraduates to experience data collection, telescope operations, data reduction and research presentation. The club hosts many star parties and various other public outreach events for the Tucson, Arizona location. The club often constructs their own outreach materials and structures. The club is currently working on creating a portable planetarium to teach about the night sky on the go even on the cloudiest of nights. The club is also working on creating a binocular telescope with two 10" mirrors as a recreation of the local Large Binocular Telescope for outreach purposes as well. This is a club that strives for undergraduate activity and involvement in a range of academic and extracurricular activates, and is welcoming to all majors of all levels in hopes to spark astronomical interest.

  7. The rich club of the C. elegans neuronal connectome.

    PubMed

    Towlson, Emma K; Vértes, Petra E; Ahnert, Sebastian E; Schafer, William R; Bullmore, Edward T

    2013-04-10

    There is increasing interest in topological analysis of brain networks as complex systems, with researchers often using neuroimaging to represent the large-scale organization of nervous systems without precise cellular resolution. Here we used graph theory to investigate the neuronal connectome of the nematode worm Caenorhabditis elegans, which is defined anatomically at a cellular scale as 2287 synaptic connections between 279 neurons. We identified a small number of highly connected neurons as a rich club (N = 11) interconnected with high efficiency and high connection distance. Rich club neurons comprise almost exclusively the interneurons of the locomotor circuits, with known functional importance for coordinated movement. The rich club neurons are connector hubs, with high betweenness centrality, and many intermodular connections to nodes in different modules. On identifying the shortest topological paths (motifs) between pairs of peripheral neurons, the motifs that are found most frequently traverse the rich club. The rich club neurons are born early in development, before visible movement of the animal and before the main phase of developmental elongation of its body. We conclude that the high wiring cost of the globally integrative rich club of neurons in the C. elegans connectome is justified by the adaptive value of coordinated movement of the animal. The economical trade-off between physical cost and behavioral value of rich club organization in a cellular connectome confirms theoretical expectations and recapitulates comparable results from human neuroimaging on much larger scale networks, suggesting that this may be a general and scale-invariant principle of brain network organization.

  8. Differentiation of Club Cells to Alveolar Epithelial Cells In Vitro

    PubMed Central

    Zheng, Dahai; Soh, Boon-Seng; Yin, Lu; Hu, Guangan; Chen, Qingfeng; Choi, Hyungwon; Han, Jongyoon; Chow, Vincent T. K.; Chen, Jianzhu

    2017-01-01

    Club cells are known to function as regional progenitor cells to repair the bronchiolar epithelium in response to lung damage. By lineage tracing in mice, we have shown recently that club cells also give rise to alveolar type 2 cells (AT2s) and alveolar type 1 cells (AT1s) during the repair of the damaged alveolar epithelium. Here, we show that when highly purified, anatomically and phenotypically confirmed club cells are seeded in 3-dimensional culture either in bulk or individually, they proliferate and differentiate into both AT2- and AT1-like cells and form alveolar-like structures. This differentiation was further confirmed by transcriptomic analysis of freshly isolated club cells and their cultured progeny. Freshly isolated club cells express Sca-1 and integrin α6, markers commonly used to characterize lung stem/progenitor cells. Together, current study for the first time isolated highly purified club cells for in vitro study and demonstrated club cells’ capacity to differentiate into alveolar epithelial cells at the single-cell level. PMID:28128362

  9. Professional Development Through The University of Arizona Astronomy Club

    NASA Astrophysics Data System (ADS)

    McGraw, Allison M.; Nieberding, Megan N.; Austin, Carmen; Hardegree-Ullman, Kevin

    2015-01-01

    The University of Arizona Astronomy Club creates a unique environment for undergraduates to accomplish goals early in their academic career. The club provides research opportunities with advisors, graduate students, and projects organized by fellow undergraduates. Undergraduates that work side-by-side develop strong working relationships which keeps students interested in astronomy and enables them to thrive in their studies and research. Club members are encouraged to attend and present their research at professional conferences where they are exposed early to the scientific research community, learn about internship and REU opportunities, and get information about graduate programs. In addition to preparing undergraduates to thrive in their academic career, the club also offers outreach opportunities for members to actively educate the southern Arizona community. Members of the club design and create many of their outreach materials including 3D models of our local stellar neighborhood and astronomical objects. Astronomy Club has had a positive impact on its members, the Department of Astronomy, and the southern Arizona community for the past seven years. The club continues to strive to improve undergraduate retention and prepare students for their future careers.

  10. Chaplain Documentation and the Electronic Medical Record: A Survey of ACPE Residency Programs.

    PubMed

    Tartaglia, Alexander; Dodd-McCue, Diane; Ford, Timothy; Demm, Charles; Hassell, Alma

    2016-01-01

    This study explores the extent to which chaplaincy departments at ACPE-accredited residency programs make use of the electronic medical record (EMR) for documentation and training. Survey data solicited from 219 programs with a 45% response rate and interview findings from 11 centers demonstrate a high level of usage of the EMR as well as an expectation that CPE residents document each patient/family encounter. Centers provided considerable initial training, but less ongoing monitoring of chaplain documentation. Centers used multiple sources to develop documentation tools for the EMR. One center was verified as having created the spiritual assessment component of the documentation tool from a peer reviewed published model. Interviews found intermittent use of the student chart notes for educational purposes. One center verified a structured manner of monitoring chart notes as a performance improvement activity. Findings suggested potential for the development of a standard documentation tool for chaplain charting and training.

  11. Using Science to Take a Stand: Action-Oriented Learning in an Afterschool Science Club

    NASA Astrophysics Data System (ADS)

    Hagenah, Sara

    This dissertation study investigates what happens when students participate in an afterschool science club designed around action-oriented science instruction, a set of curriculum design principles based on social justice pedagogy. Comprised of three manuscripts written for journal publication, the dissertation includes 1) Negotiating community-based action-oriented science teaching and learning: Articulating curriculum design principles, 2) Middle school girls' socio-scientific participation pathways in an afterschool science club, and 3) Laughing and learning together: Productive science learning spaces for middle school girls. By investigating how action-oriented science design principles get negotiated, female identity development in and with science, and the role of everyday social interactions as students do productive science, this research fills gaps in the understanding of how social justice pedagogy gets enacted and negotiated among multiple stakeholders including students, teachers, and community members along what identity development looks like across social and scientific activity. This study will be of interest to educators thinking about how to enact social justice pedagogy in science learning spaces and those interested in identity development in science.

  12. Evaluation of the remineralization capacity of CPP-ACP containing fluoride varnish by different quantitative methods

    PubMed Central

    SAVAS, Selcuk; KAVRÌK, Fevzi; KUCUKYÌLMAZ, Ebru

    2016-01-01

    ABSTRACT Objective The aim of this study was to evaluate the efficacy of CPP-ACP containing fluoride varnish for remineralizing white spot lesions (WSLs) with four different quantitative methods. Material and Methods Four windows (3x3 mm) were created on the enamel surfaces of bovine incisor teeth. A control window was covered with nail varnish, and WSLs were created on the other windows (after demineralization, first week and fourth week) in acidified gel system. The test material (MI Varnish) was applied on the demineralized areas, and the treated enamel samples were stored in artificial saliva. At the fourth week, the enamel surfaces were tested by surface microhardness (SMH), quantitative light-induced fluorescence-digital (QLF-D), energy-dispersive spectroscopy (EDS) and laser fluorescence (LF pen). The data were statistically analyzed (α=0.05). Results While the LF pen measurements showed significant differences at baseline, after demineralization, and after the one-week remineralization period (p<0.05), the difference between the 1- and 4-week was not significant (p>0.05). With regards to the SMH and QLF-D analyses, statistically significant differences were found among all the phases (p<0.05). After the 1- and 4-week treatment periods, the calcium (Ca) and phosphate (P) concentrations and Ca/P ratio were higher compared to those of the demineralization surfaces (p<0.05). Conclusion CPP-ACP containing fluoride varnish provides remineralization of WSLs after a single application and seems suitable for clinical use. PMID:27383699

  13. Cloning and characterization of a novel β-ketoacyl-ACP reductase from Comamonas testosteroni.

    PubMed

    Zhang, Hao; Ji, Ye; Wang, Yan; Zhang, Xiao; Yu, Yuanhua

    2015-06-05

    Comamonas testosteroni (C. testosteroni) is a gram negative bacterium which can use steroid as a carbon source and degrade steroid with about 20 special enzymes. Most of the enzymes are inducible enzymes. 3-Oxoacyl-ACP reductase (E.C. 1.1.1.100) alternatively known as β-ketoacyl-ACP reductase (BKR) is involved in fatty acid syntheses. DNA sequence comparison showed that BKR belongs to the short-chain alcohol dehydrogenase (SDR) family. Our results showed that BKR is necessary for the degradation of steroid hormones in C. testosteroni. The DNA fragment of the BKR gene was cloned into an expressional plasmid pET-15b. BKR protein was expressed with 6× His-tag on the N-terminus and the enzyme was purified with Ni-column. Antibodies against BKR were prepared and a new BKR quantitative ELISA was created in our laboratory. The purified BKR is a 30.6 kDa protein on SDS-PAGE. C. testosteroni was induced by testosterone, estradiol, estriol and cholesterol. The expression of BKR was detected with an ELISA. The result showed that the BKR expression could be induced by cholesterol and estriol but not by testosterone and estradiol. BKR gene knock-out mutant (M-C.T.) was prepared by homologous integration. High performance liquid chromatography (HPLC) was used to detect steroid hormone degradation in C. testosteroni ATCC11996 and BKR gene knock-out mutant. We proved that the M-C.T. eliminated of testosterone degradation. Degradations of cholesterol and estradiol were also decreased. We conclude that the novel BKR in C. testosteroni plays an important role in steroid degradation. This work provides some new information of SDR and steroid degradation in C. testosteroni.

  14. Women's Clubs as Educative Agencies: Wilmington, Delaware New Century Club, 1889-1920

    ERIC Educational Resources Information Center

    Taggart, Robert

    2006-01-01

    There is no doubt that women had a role in progressive reform a century ago, despite their lack of vote. However, it may not be so clear what the nature of this reform effort was. This article suggests that women were highly organized in women's clubs that served as a major organ of change in society, and that they had a great impact on education…

  15. Oriented and Ordered Biomimetic Remineralization of the Surface of Demineralized Dental Enamel Using HAP@ACP Nanoparticles Guided by Glycine.

    PubMed

    Wang, Haorong; Xiao, Zuohui; Yang, Jie; Lu, Danyang; Kishen, Anil; Li, Yanqiu; Chen, Zhen; Que, Kehua; Zhang, Qian; Deng, Xuliang; Yang, Xiaoping; Cai, Qing; Chen, Ning; Cong, Changhong; Guan, Binbin; Li, Ting; Zhang, Xu

    2017-01-12

    Achieving oriented and ordered remineralization on the surface of demineralized dental enamel, thereby restoring the satisfactory mechanical properties approaching those of sound enamel, is still a challenge for dentists. To mimic the natural biomineralization approach for enamel remineralization, the biological process of enamel development proteins, such as amelogenin, was simulated in this study. In this work, carboxymethyl chitosan (CMC) conjugated with alendronate (ALN) was applied to stabilize amorphous calcium phosphate (ACP) to form CMC/ACP nanoparticles. Sodium hypochlorite (NaClO) functioned as the protease which decompose amelogenin in vivo to degrade the CMC-ALN matrix and generate HAP@ACP core-shell nanoparticles. Finally, when guided by 10 mM glycine (Gly), HAP@ACP nanoparticles can arrange orderly and subsequently transform from an amorphous phase to well-ordered rod-like apatite crystals to achieve oriented and ordered biomimetic remineralization on acid-etched enamel surfaces. This biomimetic remineralization process is achieved through the oriented attachment (OA) of nanoparticles based on non-classical crystallization theory. These results indicate that finding and developing analogues of natural proteins such as amelogenin involved in the biomineralization by natural macromolecular polymers and imitating the process of biomineralization would be an effective strategy for enamel remineralization. Furthermore, this method represents a promising method for the management of early caries in minimal invasive dentistry (MID).

  16. Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase.

    PubMed

    Tipparaju, Suresh K; Joyasawal, Sipak; Forrester, Sara; Mulhearn, Debbie C; Pegan, Scott; Johnson, Michael E; Mesecar, Andrew D; Kozikowski, Alan P

    2008-06-15

    Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR.

  17. Oriented and Ordered Biomimetic Remineralization of the Surface of Demineralized Dental Enamel Using HAP@ACP Nanoparticles Guided by Glycine

    NASA Astrophysics Data System (ADS)

    Wang, Haorong; Xiao, Zuohui; Yang, Jie; Lu, Danyang; Kishen, Anil; Li, Yanqiu; Chen, Zhen; Que, Kehua; Zhang, Qian; Deng, Xuliang; Yang, Xiaoping; Cai, Qing; Chen, Ning; Cong, Changhong; Guan, Binbin; Li, Ting; Zhang, Xu

    2017-01-01

    Achieving oriented and ordered remineralization on the surface of demineralized dental enamel, thereby restoring the satisfactory mechanical properties approaching those of sound enamel, is still a challenge for dentists. To mimic the natural biomineralization approach for enamel remineralization, the biological process of enamel development proteins, such as amelogenin, was simulated in this study. In this work, carboxymethyl chitosan (CMC) conjugated with alendronate (ALN) was applied to stabilize amorphous calcium phosphate (ACP) to form CMC/ACP nanoparticles. Sodium hypochlorite (NaClO) functioned as the protease which decompose amelogenin in vivo to degrade the CMC-ALN matrix and generate HAP@ACP core-shell nanoparticles. Finally, when guided by 10 mM glycine (Gly), HAP@ACP nanoparticles can arrange orderly and subsequently transform from an amorphous phase to well-ordered rod-like apatite crystals to achieve oriented and ordered biomimetic remineralization on acid-etched enamel surfaces. This biomimetic remineralization process is achieved through the oriented attachment (OA) of nanoparticles based on non-classical crystallization theory. These results indicate that finding and developing analogues of natural proteins such as amelogenin involved in the biomineralization by natural macromolecular polymers and imitating the process of biomineralization would be an effective strategy for enamel remineralization. Furthermore, this method represents a promising method for the management of early caries in minimal invasive dentistry (MID).

  18. Oriented and Ordered Biomimetic Remineralization of the Surface of Demineralized Dental Enamel Using HAP@ACP Nanoparticles Guided by Glycine

    PubMed Central

    Wang, Haorong; Xiao, Zuohui; Yang, Jie; Lu, Danyang; Kishen, Anil; Li, Yanqiu; Chen, Zhen; Que, Kehua; Zhang, Qian; Deng, Xuliang; Yang, Xiaoping; Cai, Qing; Chen, Ning; Cong, Changhong; Guan, Binbin; Li, Ting; Zhang, Xu

    2017-01-01

    Achieving oriented and ordered remineralization on the surface of demineralized dental enamel, thereby restoring the satisfactory mechanical properties approaching those of sound enamel, is still a challenge for dentists. To mimic the natural biomineralization approach for enamel remineralization, the biological process of enamel development proteins, such as amelogenin, was simulated in this study. In this work, carboxymethyl chitosan (CMC) conjugated with alendronate (ALN) was applied to stabilize amorphous calcium phosphate (ACP) to form CMC/ACP nanoparticles. Sodium hypochlorite (NaClO) functioned as the protease which decompose amelogenin in vivo to degrade the CMC-ALN matrix and generate HAP@ACP core-shell nanoparticles. Finally, when guided by 10 mM glycine (Gly), HAP@ACP nanoparticles can arrange orderly and subsequently transform from an amorphous phase to well-ordered rod-like apatite crystals to achieve oriented and ordered biomimetic remineralization on acid-etched enamel surfaces. This biomimetic remineralization process is achieved through the oriented attachment (OA) of nanoparticles based on non-classical crystallization theory. These results indicate that finding and developing analogues of natural proteins such as amelogenin involved in the biomineralization by natural macromolecular polymers and imitating the process of biomineralization would be an effective strategy for enamel remineralization. Furthermore, this method represents a promising method for the management of early caries in minimal invasive dentistry (MID). PMID:28079165

  19. Rhamnolipid and poly (hydrozyalkanoate) biosynthesis in 3-hydrozyacyl-ACP:COA transacylase (phaG) - knockouts of pseudomonas chloroaphis

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The 3-hydroxyacyl-ACP:CoA transacylase gene (phaG(Pc30761)) of P. chlororaphis NRRL B-30761 was cloned and analyzed. The nucleotide and translated amino-acid sequences of phaG(Pc30761) had 99% identities (at 100% query coverage) with the phaG gene of P. fluorescens O6. Two phaG-knockout strains of...

  20. Ferritin, finger clubbing, and lung disease.

    PubMed Central

    Shneerson, J M; Jones, B M

    1981-01-01

    The serum ferritin concentration has been determined by an immunoradiometric assay in 90 subjects with a variety of pulmonary diseases. No association between ferritin concentrations and finger clubbing has been found in any of the diseases studied. Ferritin levels were significantly raised in the subjects with bronchial carcinoma, but were not useful in monitoring recurrence of the tumour. Pulmonary artery and pulmonary vein ferritin concentrations were similar to systemic venous concentrations. It is therefore unlikely that the tumour releases ferritin into the pulmonary circulation. Ferritin levels were raised in patients with acute pneumonias but did not correlate with the total white cell count or erythrocyte sedimentation rate. Serum ferritin concentrations were also increased in a variety of chronic lung diseases but were normal in subjects with asbestosis. PMID:7314044

  1. Expression of Cyanobacterial Acyl-ACP Reductase Elevates the Triacylglycerol Level in the Red Alga Cyanidioschyzon merolae.

    PubMed

    Sumiya, Nobuko; Kawase, Yasuko; Hayakawa, Jumpei; Matsuda, Mami; Nakamura, Mami; Era, Atsuko; Tanaka, Kan; Kondo, Akihiko; Hasunuma, Tomohisa; Imamura, Sousuke; Miyagishima, Shin-ya

    2015-10-01

    Nitrogen starvation is known to induce the accumulation of triacylglycerol (TAG) in many microalgae, and potential use of microalgae as a source of biofuel has been explored. However, nitrogen starvation also stops cellular growth. The expression of cyanobacterial acyl-acyl carrier protein (ACP) reductase in the unicellular red alga Cyanidioschyzon merolae chloroplasts resulted in an accumulation of TAG, which led to an increase in the number and size of lipid droplets while maintaining cellular growth. Transcriptome and metabolome analyses showed that the expression of acyl-ACP reductase altered the activities of several metabolic pathways. The activities of enzymes involved in fatty acid synthesis in chloroplasts, such as acetyl-CoA carboxylase and pyruvate dehydrogenase, were up-regulated, while pyruvate decarboxylation in mitochondria and the subsequent consumption of acetyl-CoA by the tricarboxylic acid (TCA) cycle were down-regulated. Aldehyde dehydrogenase, which oxidizes fatty aldehydes to fatty acids, was also up-regulated in the acyl-ACP reductase expresser. This activation was required for the lipid droplet accumulation and metabolic changes observed in the acyl-ACP reductase expresser. Nitrogen starvation also resulted in lipid droplet accumulation in C. merolae, while cell growth ceased as in the case of other algal species. The metabolic changes that occur upon the expression of acyl-ACP reductase are quite different from those caused by nitrogen starvation. Therefore, there should be a method for further increasing the storage lipid level while still maintaining cell growth that is different from the metabolic response to nitrogen starvation.

  2. Microleakage of Three Types of Glass Ionomer Cement Restorations: Effect of CPP-ACP Paste Tooth Pretreatment

    PubMed Central

    Doozandeh, Maryam; Shafiei, Fereshteh; Alavi, Mostafa

    2015-01-01

    Statement of the Problem Casein phosphopeptide–amorphous calcium phosphate (CPP-ACP) increases the mineral content of tooth structure. This may enhance the chemical bonding of glass ionomer cements (GIC) and marginal sealing of their restorations. Purpose The aim of this study was to evaluate the effect of CPP-ACP paste pretreatment on the microleakage of three types of GIC. Materials and Method In this study, 72 Class V cavities were prepared on the buccal and lingual surfaces of molars with occlusal margins in enamel and gingival margins in root. The cavities were divided into 6 groups. Cavities in group 1 and 2 were restored with Fuji II, group 3 and 4 with Fuji II LC, and group 5 and 6 with Ketac N100 with respect to the manufacturers’ instructions. In groups 2, 4 and 6, CPP-ACP containing paste (MI paste) was placed into the cavities for 3 minutes before being filled with GIC. The teeth were thermocycled, stained with dye, sectioned, and scored for microleakage under stereomicroscope. Kruskall-Wallis and Chi-Square tests were used to analyze the data. Result There were no statistically significant differences between the control and the CPP-ACP pretreatment groups in enamel and dentin margins. In pairwise comparisons, there were no significant differences between the control and the experimental groups in enamel margin, and in dentin margins of G1 and 2, G5 and 6; however, a significant differences was detected in dentin margins between G3 and 4 (p= 0.041). Conclusion CPP-ACP paste pretreatment did not affect the microleakage of Fuji II and Ketac N100 in enamel or dentin, but decreased the microleakage in dentine margins of Fuji II LC when cavity conditioner was applied before surface treatment. PMID:26331147

  3. An in vitro study on the retentive strength of orthodontic bands cemented with CPP-ACP-containing GIC

    NASA Astrophysics Data System (ADS)

    Heravi, Farzin; Bagheri, Hossein; Rangrazi, Abdolrasoul; Mojtaba Zebarjad, Seyed

    2016-12-01

    Caries and white spot lesions around orthodontic bands are well known occurrences in fixed orthodontic treatment. There are several methods to overcome these problems. One of these includes modification of the band cement with remineralizing agents such as casein phosphopeptide-amorphous calcium phosphate (CPP-ACP). However, it should be evaluated that the cement modification has no significant negative effects on the retentive strength of the cemented orthodontic bands. In a continuation of our previous studies on the effects of the addition of CPP-ACP on the mechanical properties of luting and lining glass ionomer cement (GIC), this study aimed to investigate the retentive strength of orthodontic bands cemented with CPP-ACP containing GIC. Sixty extracted human pre molars teeth were embedded in acrylic resin and randomly divided into two groups of 30 specimens. In group 1, bands were cemented to the tooth with a GIC. In group 2, CPP-ACP (1.56% w/w) was added to the GIC before cementation. The retentive strength of each groups was determined with a universal testing machine. Further, the amount of cement remaining on the tooth surface was evaluated under a stereomicroscope, and the adhesive remnant index (ARI) score was determined. Results of this study showed that there were no significant differences between the groups in retentive strength and ARI score. In conclusion, modification of GIC with 1.56% w/w CPP-ACP had no negative effects on the retentive strength of the bands so can be used during fixed orthodontic treatment.

  4. 7. CLUBHOUSE. FIREPLACE IN CLUB ROOM. VIEW TO NORTHWEST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. CLUBHOUSE. FIREPLACE IN CLUB ROOM. VIEW TO NORTHWEST. - Rainbow Hydroelectric Facility, Clubhouse, On north bank of Missouri River 2 miles Northeast of Great Falls, & end of Rainbow Dam Road, Great Falls, Cascade County, MT

  5. Southern Nevadas Club Ride Commuter Service Wins EPA Honor

    EPA Pesticide Factsheets

    · Clean Air Partners Program - CLEAN AIR Force of Central Texas · Club Ride Commuter Services - Regional Transportation Commission of Southern Nevada · Air Quality Partnership of the Delaware Valley - Delaware Valley Regional Planning

  6. 12. Historic American Buildings Survey Topographic Survey of Cosmos Club, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Historic American Buildings Survey Topographic Survey of Cosmos Club, 1950, by Bernard Locroft, Civil Engineer (Showing Grounds as They Were at End of Sumner Welles Era) SITE PLAN - Townsend House, 2121 Massachusetts Avenue Northwest, Washington, District of Columbia, DC

  7. Leading the Fit Life: Jobs in Health Clubs.

    ERIC Educational Resources Information Center

    Green, Kathleen

    1995-01-01

    Depicts the health club work force: fitness personnel, such as instructors, trainers, and directors, and nonfitness personnel, such as receptionists, marketers, and managers, as well as physicians and therapists. Gives information on how to acquire credentials in the field. (SK)

  8. Encouraging a Culture of Outreach in Astronomy Clubs

    NASA Astrophysics Data System (ADS)

    Manning, J.; Berendsen, M.; Schultz, G.; Gurton, S.; Santascoy, J.; White, V.; Frank, K.; Jones, E.; Yocco, V.; John, M. S.; Castori, P.

    2014-07-01

    Astronomy clubs constitute a “marching army” of knowledgeable, experienced astronomy enthusiasts deployed in a national network: an important resource for engaging the public through educational outreach events and activities. The Astronomical Society of the Pacific (ASP) in partnership with the Institute for Learning Innovation (ILI) and Inverness Research, Inc., has been engaged in a multi-year NSF-supported project focusing on this network and its potential to advance astronomy education and outreach. The project has explored the culture of astronomy clubs, identified impediments to building cultures of outreach within clubs, and developed and introduced new mechanisms to overcome these impediments and enhance clubs' abilities to encourage and sustain cultures that value and promote outreach efforts. This paper shares initial research, development and evaluation findings of the project, and describes ongoing supplemental efforts that continue to advance project objectives.

  9. 4. INTERIOR VIEW OF CLUB HOUSE REFRIGERATION UNIT, SHOWING COOLING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. INTERIOR VIEW OF CLUB HOUSE REFRIGERATION UNIT, SHOWING COOLING COILS AND CORK-LINED ROOM. CAMERA IS BETWEEN SEVEN AND EIGHT FEET ABOVE FLOOR LEVEL, FACING SOUTHEAST. - Swan Falls Village, Clubhouse 011, Snake River, Kuna, Ada County, ID

  10. Country Club Estates, LLC - Clean Water Act Public Notice

    EPA Pesticide Factsheets

    The EPA is providing notice of an Administrative Penalty Assessment in the form of an Expedited Storm Water Settlement Agreement against Country Club Estates, LLC, a business located at 3415 Mulberry Dr., Marion, Iowa, for alleged violations at Tower Tenac

  11. 14. Photocopy of Photograph (Courtesy of the Detroit Hockey Club, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Photocopy of Photograph (Courtesy of the Detroit Hockey Club, Detroit, Michigan). AERIAL VIEW OF OLYMPIA ARENA, LOOKING NORTH, FEBRUARY 9, 1969. - Olympia Arena, 5920 Grand River Avenue, Detroit, MI

  12. Navy Flying Clubs: Management Control Systems and Performance Measures

    DTIC Science & Technology

    2002-12-01

    BUPERS Instruction 1710.22. The budget is not combined with the local MWR budget when the overall MWR budget is submitted to MWR headquarters. The...to evaluate Monterey Navy Flying Clubs control systems is a SWOT (Strength, Weaknesses, Opportunities, and Threats) analysis. The strengths and...on the local MWR business office to provide the business guidance for each flying club. [Ref. 1] The implied assumption is that the business office

  13. R&W Club Frederick Sews for Kids | Poster

    Cancer.gov

    By Carolynne Keenan, Contributing Writer Sewing enthusiasts of all skill levels are invited to attend a sewing party hosted by the R&W Club Frederick on Feb. 18. Stop by the Building 549 Café Room between 10 a.m. and 4 p.m. to sew for a cause: help the club make pillowcases for ConKerr Cancer, a nonprofit organization that supports children in hospitals across the country.

  14. HPGD mutations cause cranioosteoarthropathy but not autosomal dominant digital clubbing.

    PubMed

    Seifert, Wenke; Beninde, Julia; Hoffmann, Katrin; Lindner, Tom H; Bassir, Christian; Aksu, Fuat; Hübner, Christoph; Verbeek, Nienke E; Mundlos, Stefan; Horn, Denise

    2009-12-01

    Cranio-osteoarthropathy, clinically classified as a variant of primary hypertrophic osteoarthropathy, is a very rare autosomal-recessive condition characterized by delayed closure of the cranial sutures and fontanels, digital clubbing, arthropathy, and periostosis. Recently, mutations in the gene HPGD, which encodes the NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase, were reported in four families affected with primary hypertrophic osteoarthropathy and one family with autosomal-recessive isolated nail clubbing. We report the clinical and molecular findings in four patients from two families affected with cranio-osteoarthropathy and one family with isolated, autosomal dominant digital clubbing. Genome-wide homozygosity mapping identified a locus for cranio-osteoarthropathy harboring the HPGD gene in one affected family. We detected two novel homozygous mutations in HPGD in these families: a missense mutation affecting the NAD(+) binding motif and a frameshift mutation. The clinical presentation in our patients was variable. Digital clubbing and hyperhidrosis were present in all cases. Delayed closure of the cranial sutures and fontanels, periostosis, and arthropathy were not consistent clinical features. No HPGD mutation was detected in a familial case of autosomal dominant isolated digital clubbing. The failure to identify any mutation in a family with an autosomal dominant type of isolated digital clubbing suggests that HPGD is not the major gene for this condition.

  15. Digital clubbing in HIV-infected patients: an observational study.

    PubMed

    Dever, Lisa L; Matta, Jyoti S

    2009-01-01

    Digital clubbing is characterized by bulbous enlargement of the distal phalanges due to an increase in soft tissue. It has been associated with a variety of conditions including cyanotic heart disease, neoplasms and infections of the lungs, bronchiectasis, liver cirrhosis, and inflammatory bowel disease. We conducted an observational study at an urban Veterans Affairs Medical Center outpatient HIV clinic to confirm our clinical impression that clubbing is common in HIV-infected patients and to identify factors that might be associated with it. Clinical, laboratory, and physical examination data including measurement of the circumference of the nail bed and distal phalanx of each finger were obtained on 78 HIV-infected patients seen for their routine care over a 3-month period. A digital index (DI), the ratio of the nail bed:distal phalanx circumference was determined for each patient. Clubbing was found in 28 patients (36%). Clubbed patients did not differ from nonclubbed patients with respect to most patient characteristics; CD4 cell counts and quantitative HIV RNA were similar in both groups. Clubbed patients had a significantly higher DI than controls (1.03 versus 0.96, p < 0.001), were younger (45 versus 49 years, p = 0.04), and had longer duration of HIV disease (48 versus, 42 months, p = 0.03). HIV infection should be considered in the differential diagnosis of acquired digital clubbing.

  16. Who will volunteer? Analysing individual and structural factors of volunteering in Swiss sports clubs.

    PubMed

    Schlesinger, Torsten; Nagel, Siegfried

    2013-01-01

    This article analyses the conditions influencing volunteering in sports clubs. It focuses not only on individual characteristics of volunteers but also on the corresponding structural conditions of sports clubs. It proposes a model of voluntary work in sports clubs based on economic behaviour theory. The influences of both the individual and context levels on the decision to engage in voluntary work are estimated in different multilevel models. Results of these multilevel analyses indicate that volunteering is not just an outcome of individual characteristics such as lower workloads, higher income, children belonging to the sports club, longer club memberships, or a strong commitment to the club. It is also influenced by club-specific structural conditions; volunteering is more probable in rural sports clubs whereas growth-oriented goals in clubs have a destabilising effect.

  17. Crystal structure of FabZ-ACP complex reveals a dynamic seesaw-like catalytic mechanism of dehydratase in fatty acid biosynthesis.

    PubMed

    Zhang, Lin; Xiao, Jianfeng; Xu, Jianrong; Fu, Tianran; Cao, Zhiwei; Zhu, Liang; Chen, Hong-Zhuan; Shen, Xu; Jiang, Hualiang; Zhang, Liang

    2016-12-01

    Fatty acid biosynthesis (FAS) is a vital process in cells. Fatty acids are essential for cell assembly and cellular metabolism. Abnormal FAS directly correlates with cell growth delay and human diseases, such as metabolic syndromes and various cancers. The FAS system utilizes an acyl carrier protein (ACP) as a transporter to stabilize and shuttle the growing fatty acid chain throughout enzymatic modules for stepwise catalysis. Studying the interactions between enzymatic modules and ACP is, therefore, critical for understanding the biological function of the FAS system. However, the information remains unclear due to the high flexibility of ACP and its weak interaction with enzymatic modules. We present here a 2.55 Å crystal structure of type II FAS dehydratase FabZ in complex with holo-ACP, which exhibits a highly symmetrical FabZ hexamer-ACP3 stoichiometry with each ACP binding to a FabZ dimer subunit. Further structural analysis, together with biophysical and computational results, reveals a novel dynamic seesaw-like ACP binding and catalysis mechanism for the dehydratase module in the FAS system, which is regulated by a critical gatekeeper residue (Tyr100 in FabZ) that manipulates the movements of the β-sheet layer. These findings improve the general understanding of the dehydration process in the FAS system and will potentially facilitate drug and therapeutic design for diseases associated with abnormalities in FAS.

  18. Crystal structure of FabZ-ACP complex reveals a dynamic seesaw-like catalytic mechanism of dehydratase in fatty acid biosynthesis

    PubMed Central

    Zhang, Lin; Xiao, Jianfeng; Xu, Jianrong; Fu, Tianran; Cao, Zhiwei; Zhu, Liang; Chen, Hong-Zhuan; Shen, Xu; Jiang, Hualiang; Zhang, Liang

    2016-01-01

    Fatty acid biosynthesis (FAS) is a vital process in cells. Fatty acids are essential for cell assembly and cellular metabolism. Abnormal FAS directly correlates with cell growth delay and human diseases, such as metabolic syndromes and various cancers. The FAS system utilizes an acyl carrier protein (ACP) as a transporter to stabilize and shuttle the growing fatty acid chain throughout enzymatic modules for stepwise catalysis. Studying the interactions between enzymatic modules and ACP is, therefore, critical for understanding the biological function of the FAS system. However, the information remains unclear due to the high flexibility of ACP and its weak interaction with enzymatic modules. We present here a 2.55 Å crystal structure of type II FAS dehydratase FabZ in complex with holo-ACP, which exhibits a highly symmetrical FabZ hexamer-ACP3 stoichiometry with each ACP binding to a FabZ dimer subunit. Further structural analysis, together with biophysical and computational results, reveals a novel dynamic seesaw-like ACP binding and catalysis mechanism for the dehydratase module in the FAS system, which is regulated by a critical gatekeeper residue (Tyr100 in FabZ) that manipulates the movements of the β-sheet layer. These findings improve the general understanding of the dehydration process in the FAS system and will potentially facilitate drug and therapeutic design for diseases associated with abnormalities in FAS. PMID:27874013

  19. Whither Electronic Journals?

    ERIC Educational Resources Information Center

    Luther, Judy

    2000-01-01

    Discusses Web-based electronic journals for the academic market and presents a chart that includes sources of electronic journals and value added. Considers trends in collections, including remote access, outsourcing, hosting content versus linking, and subject portals; trends in access, including indexing, backfiles, and database usage; and…

  20. Journals and Program Assessment

    ERIC Educational Resources Information Center

    Cluphf, David J.; Lox, Curt L.

    2009-01-01

    The purpose of this study was to use journal feedback from student teachers to understand and document how well the Physical Education-Teacher Education (PETE) program prepares teacher candidates in relation to the three primary goals of the PETE program. Analysis of the journals revealed areas of merit and concern for the PETE faculty. The most…

  1. Rewriting the Journal

    ERIC Educational Resources Information Center

    Fredette, Michelle

    2012-01-01

    With faculty balking at the price of academic journals, can other digital publishing options get traction? University libraries are no strangers to one of the most popular online alternatives, the open-access archive. These archives enable scholars to upload work--including drafts of articles that are published later in subscription journals--so…

  2. The Journal Book.

    ERIC Educational Resources Information Center

    Fulwiler, Toby, Ed.

    Essays on the use of journal writing in the classroom are presented in four sections: the language of speculation, journals in the teaching of English, the arts and humanities, and the quantitative disciplines. Titles and authors are as follows: (1) "Dialectical Notebooks and the Audit of Meaning" (A. E. Berthoff); (2) "Desert…

  3. YALA Journal, 1990.

    ERIC Educational Resources Information Center

    YALA Journal, 1990

    1990-01-01

    The YALA journal is an annual publication of the Young Adult Learning Academy (YALA) in New York City, New York. This journal, one of many YALA publications and projects, was designed to encourage students to assume active roles in their education and to present their ideas, feelings, and craft to others. The YALA was established in 1984 to…

  4. Electronic Journalism: More Fear?

    ERIC Educational Resources Information Center

    Terry, Carolyn

    2002-01-01

    Considers how the same First Amendment protections that govern print journalism apply to electronic practitioners. Discusses how the number of broadcast and online journalism classes at the nation's high schools demonstrate steady growth, according to a survey conducted in the fall of 2001 for the Radio and Television News Directors Foundation.…

  5. Writing for Education Journals.

    ERIC Educational Resources Information Center

    Henson, Kenneth T.

    1990-01-01

    Based on questionnaires sent to education journal editors, this article explains the intricacies of writing for publication. Practical information is provided concerning rejection rates, the nature of refereed journals, the necessity of targeting articles to meet editorial specifications and particular audiences, and manuscript preparation. (MLH)

  6. Journal club: molecular breast imaging at reduced radiation dose for supplemental screening in mammographically dense breasts.

    PubMed

    Rhodes, Deborah J; Hruska, Carrie B; Conners, Amy Lynn; Tortorelli, Cindy L; Maxwell, Robert W; Jones, Katie N; Toledano, Alicia Y; O'Connor, Michael K

    2015-02-01

    OBJECTIVE. The purpose of this study was to assess the diagnostic performance of supplemental screening molecular breast imaging (MBI) in women with mammographically dense breasts after system modifications to permit radiation dose reduction. SUBJECTS AND METHODS. A total of 1651 asymptomatic women with mammographically dense breasts on prior mammography underwent screening mammography and adjunct MBI performed with 300-MBq (99m)Tc-sestamibi and a direct-conversion (cadmium zinc telluride) gamma camera, both interpreted independently. The cancer detection rate, sensitivity, specificity, and positive predictive value of biopsies performed (PPV3) were determined. RESULTS. In 1585 participants with a complete reference standard, 21 were diagnosed with cancer: two detected by mammography only, 14 by MBI only, three by both modalities, and two by neither. Of 14 participants with cancers detected only by MBI, 11 had invasive disease (median size, 0.9 cm; range, 0.5-4.1 cm). Nine of 11 (82%) were node negative, and two had bilateral cancers. With the addition of MBI to mammography, the overall cancer detection rate (per 1000 screened) increased from 3.2 to 12.0 (p < 0.001) (supplemental yield 8.8). The invasive cancer detection rate increased from 1.9 to 8.8 (p < 0.001) (supplemental yield 6.9), a relative increase of 363%, while the change in DCIS detection was not statistically significant (from 1.3 to 3.2, p =0.250). For mammography alone, sensitivity was 24%; specificity, 89%; and PPV3, 25%. For the combination, sensitivity was 91% (p < 0.001); specificity, 83% (p < 0.001); and PPV3, 28% (p = 0.70). The recall rate increased from 11.0% with mammography alone to 17.6% (p < 0.001) for the combination; the biopsy rate increased from 1.3% for mammography alone to 4.2% (p < 0.001). CONCLUSION. When added to screening mammography, MBI performed using a radiopharmaceutical activity acceptable for screening (effective dose 2.4 mSv) yielded a supplemental cancer detection rate of 8.8 per 1000 women with mammographically dense breasts.

  7. Integrated Literacies in a Rural Kenyan Girls' Secondary School Journalism Club

    ERIC Educational Resources Information Center

    Kendrick, Maureen; Early, Margaret; Chemjor, Walter

    2013-01-01

    Our purpose in this paper is to foreground contextual issues in studies of situated writing practices. During a year-long case study in a rural Kenyan secondary school, we applied a number of ethnographic techniques to document how 32 girls (aged 14-18 years) used local cultural and digital resources (i.e., donated digital cameras, voice…

  8. Teachers' Journal Club: Bridging between the Dynamics of Biological Discoveries and Biology Teachers

    ERIC Educational Resources Information Center

    Brill, Gilat; Falk, Hedda; Yarden, Anat

    2003-01-01

    Since biology is one of the most dynamic research fields within the natural sciences, the gap between the accumulated knowledge in biology and the knowledge that is taught in schools, increases rapidly with time. Our long-term objective is to develop means to bridge between the dynamics of biological discoveries and the biology teachers and…

  9. Uses and Benefits of Journal Writing.

    ERIC Educational Resources Information Center

    Hiemstra, Roger

    2001-01-01

    Describes various types of journals: learning journals, diaries, dream logs, autobiographies, spiritual journals, professional journals, interactive reading logs, theory logs, and electronic journals. Lists benefits of journal writing and ways to overcome writing blocks. (Contains 19 references.) (SK)

  10. The Design and Development of a Management Information System for the Monterey Navy Flying Club.

    DTIC Science & Technology

    1986-03-27

    Management Information System for the Monterey Navy Flying Club. It supplies the tools necessary to enable the club manager to maintain all club records and generate required administrative and financial reports. The Monterey Navy Flying Club has one of the largest memberships of the Navy sponsored flying clubs. As a result of this large membership and the amount of manual paperwork required to properly maintain club records, the Manager’s ability to provide necessary services and reports in severely hampered. The implementation of an efficient

  11. Radiosynthesis and biological evaluation of a novel enoyl-ACP reductase inhibitor for Staphylococcus aureus

    PubMed Central

    Wang, Hui; Lu, Yang; Liu, Li; Kim, Sung Won; Hooker, Jacob M.; Fowler, Joanna S.; Tonge, Peter J.

    2014-01-01

    The pharmacokinetics (PK) and pharmacodynamics (PD) of PT119, a potent Staphylococcus aureus enoyl-ACP reductase (saFabI) inhibitor with a Ki value of 0.01 nM and a residence time of 750 min on the enzyme target, has been evaluated in mice. PT119 was found to have promising antibacterial activity in two different S. aureus infection models: it caused a 3 log reduction in the CFU’s in a mouse thigh muscle infection model and increased the survival rate from 0% to 50% in a mouse systemic infection model. PT119 was then radiolabeled with carbon-11 to evaluate its biodistribution and PK in both healthy and S. aureus infected mice using positron emission tomography (PET). The biodistribution of [11C]PT119 and/or its labeled metabolites did not differ significantly between the healthy group and the infected group, and PT119 was found to distribute equally between serum and tissue during the ~1 h of analysis permitted by the carbon-11 half life. This approach provides important data for PK/PD modeling and is the first step in identifying radiotracers that can non-invasively image bacterial infection in vivo. PMID:25217335

  12. Targeting InhA, the FASII Enoyl-ACP Reductase: SAR Studies on Novel Inhibitor Scaffolds

    PubMed Central

    Pan, Pan; Tonge, Peter J.

    2015-01-01

    The bacterial type II fatty acid biosynthesis (FASII) pathway is an essential but unexploited target for drug discovery. In this review we summarize SAR studies on inhibitors of InhA, the enoyl-ACP reductase from the FASII pathway in M. tuberculosis. Inhibitor scaffolds that are described include the diaryl ethers, pyrrolidine carboxamides, piperazine indoleformamides, pyrazoles, arylamides, fatty acids, and imidazopiperidines, all of which form ternary complexes with InhA and the NAD cofactor, as well as isoniazid and the diazaborines which covalently modify the cofactor. Analysis of the structural data has enabled the development of a common binding mode for the ternary complex inhibitors, which includes a hydrogen bond network, a large hydrophobic pocket and a third ‘size-limited’ binding area comprised of both polar and non-polar groups. A critical factor in InhA inhibition involves ordering of the substrate binding loop, located close to the active site, and a direct link is proposed between loop ordering and slow onset enzyme inhibition. Slow onset inhibitors have long residence times on the enzyme target, a property that is of critical importance for in vivo activity. PMID:22283812

  13. The sex-peptide gene (Acp70A) is duplicated in Drosophila subobscura.

    PubMed

    Cirera, S; Aguadé, M

    1998-04-14

    A 3.1-kb region of Drosphila subobscura homologous to the Acp70A region of D. melanogaster, which contains the sex-peptide gene, was cloned and sequenced. This region contains an approximately 600-bp duplication that includes the sex-peptide and its 5' and 3' flanking regions. The preproteins are 54 and 56 amino acids long, respectively (as compared to 55 amino acids in D. melanogaster), and each includes a 19-amino-acid-long signal peptide. The C-terminal part of the mature peptide is highly conserved between D. melanogaster and the two copies of D. subobscura. In this species, both copies of the gene are transcribed and, like in D. melangaster, only expressed in males. The duplicated region includes 300 bp upstream of the gene that would therefore seem sufficient for their expression in males. This region presents at its 5' end a stretch 93-bp that has a high similarity with the corresponding region of D. melanogaster and could be part of a still unidentified regulatory element of these genes.

  14. Radiosynthesis and biological evaluation of a novel enoyl-ACP reductase inhibitor for Staphylococcus aureus

    SciTech Connect

    Wang, Hui; Lu, Yang; Liu, Li; Kim, Sung Won; Hooker, Jacob M.; Fowler, Joanna S.; Tonge, Peter J.

    2014-09-06

    Here we evaluated the pharmacokinetics (PK) and pharmacodynamics (PD) of PT119, a potent Staphylococcus aureus enoyl-ACP reductase (saFabI) inhibitor with a Ki value of 0.01 nM and a residence time of 750 min on the enzyme target in mice. PT119 was found to have promising antibacterial activity in two different S. aureus infection models: it caused a 3 log reduction in the CFU’s in a mouse thigh muscle infection model and increased the survival rate from 0% to 50% in a mouse systemic infection model. PT119 was then radiolabeled with carbon-11 to evaluate its biodistribution and PK in both healthy and S. aureus infected mice using positron emission tomography (PET). The biodistribution of [11C]PT119 and/or its labeled metabolites did not differ significantly between the healthy group and the infected group, and PT119 was found to distribute equally between serum and tissue during the ~1 h of analysis permitted by the carbon-11 half life. This approach provides important data for PK/PD modeling and is the first step in identifying radiotracers that can non-invasively image bacterial infection in vivo.

  15. Radiosynthesis and biological evaluation of a novel enoyl-ACP reductase inhibitor for Staphylococcus aureus

    DOE PAGES

    Wang, Hui; Lu, Yang; Liu, Li; ...

    2014-09-06

    Here we evaluated the pharmacokinetics (PK) and pharmacodynamics (PD) of PT119, a potent Staphylococcus aureus enoyl-ACP reductase (saFabI) inhibitor with a Ki value of 0.01 nM and a residence time of 750 min on the enzyme target in mice. PT119 was found to have promising antibacterial activity in two different S. aureus infection models: it caused a 3 log reduction in the CFU’s in a mouse thigh muscle infection model and increased the survival rate from 0% to 50% in a mouse systemic infection model. PT119 was then radiolabeled with carbon-11 to evaluate its biodistribution and PK in both healthymore » and S. aureus infected mice using positron emission tomography (PET). The biodistribution of [11C]PT119 and/or its labeled metabolites did not differ significantly between the healthy group and the infected group, and PT119 was found to distribute equally between serum and tissue during the ~1 h of analysis permitted by the carbon-11 half life. This approach provides important data for PK/PD modeling and is the first step in identifying radiotracers that can non-invasively image bacterial infection in vivo.« less

  16. Disruption of rich club organisation in cerebral small vessel disease.

    PubMed

    Tuladhar, Anil M; Lawrence, Andrew; Norris, David G; Barrick, Thomas R; Markus, Hugh S; de Leeuw, Frank-Erik

    2017-04-01

    Cerebral small vessel disease (SVD) is an important cause of vascular cognitive impairment. Recent studies have demonstrated that structural connectivity of brain networks in SVD is disrupted. However, little is known about the extent and location of the reduced connectivity in SVD. Here they investigate the rich club organisation-a set of highly connected and interconnected regions-and investigate whether there is preferential rich club disruption in SVD. Diffusion tensor imaging (DTI) and cognitive assessment were performed in a discovery sample of SVD patients (n = 115) and healthy control subjects (n = 50). Results were replicated in an independent dataset (49 SVD with confluent WMH cases and 108 SVD controls) with SVD patients having a similar SVD phenotype to that of the discovery cases. Rich club organisation was examined in structural networks derived from DTI followed by deterministic tractography. Structural networks in SVD patients were less dense with lower network strength and efficiency. Reduced connectivity was found in SVD, which was preferentially located in the connectivity between the rich club nodes rather than in the feeder and peripheral connections, a finding confirmed in both datasets. In discovery dataset, lower rich club connectivity was associated with lower scores on psychomotor speed (β = 0.29, P < 0.001) and executive functions (β = 0.20, P = 0.009). These results suggest that SVD is characterized by abnormal connectivity between rich club hubs in SVD and provide evidence that abnormal rich club organisation might contribute to the development of cognitive impairment in SVD. Hum Brain Mapp 38:1751-1766, 2017. © 2017 Wiley Periodicals, Inc.

  17. [Almaty club "KAIRAT" young football players' health].

    PubMed

    Kausova, G K; Karabaeva, A I

    2013-10-01

    The aim of the investigation was to study young football players' health. The study was conducted on 161 football players (mean age 12.3) of six children football teams of Almaty club "KAIRAT" during the competition period. It was found that 55,5% of the football players are practically healthy; 18,6% of football players have iron deficiency anemia. 32,6% of football players have caries; 5% of football players have problems of cardiopulmonary system. Investigation reveal, that in a junior sportsman was body weigh surging with downtrend during contest, testify to portability of aerobic load and in childhood unconformable of metabolism' level. This tendency was retain also in the oldest sportsman, this testify to most emulative aerobic load in comparison with junior sportsman. According as the age increases it is emulative load's extension and free occurrence of body weigh subsequent reduction but in the oldest sportsman with prevalence macrosomia. Concurrently with improvement of the anthropometric profile as far as increase of age in soccer players it is forming of a high training level. In spite of lowering of energy resources and the physical load organism's adaptation there are these phenomena. According as the age increases in a soccer player's performance of cardiac and respiratory system are improved.

  18. The Cost of Journals

    NASA Astrophysics Data System (ADS)

    Moore, John W.

    1997-08-01

    On page 896 we announce appointment of a new Publications Coordinator for the Journal, Richard Schwenz of the University of Northern Colorado. After five years of yeoman service, Ken Emerson of Montana State University, is retiring. Ken has seen the Journal through a lot of change: a new editor, a new advertising representative, a new subscription fulfillment agent, and a consolidation of the Journal's print, software, and online operations. All this has taken a lot of work and intelligence, and the entire editorial staff thanks Ken for all of his efforts on our behalf.

  19. Hydrogeology Journal in 2004

    USGS Publications Warehouse

    Voss, Clifford; Olcott, Perry; Schneider, Robert; Watson, Christine

    2004-01-01

    Hydrogeology Journal continues to flourish. The increase in the size of our yearly volume attests to the success and growing international reputation of the journal. Until 2001, HJ produced about 600 printed pages each year. This number has steadily increased, and in 2005 and 2006, HJ will be allocated 800 pages per year by the publisher. Despite this good news, the journal is having some growing pains. Most pages in next year’s issues are already fully allocated with currently accepted articles and therefore, many accepted articles must now wait up to one year to appear in printed form. Clearly, this is not an acceptable situation for authors or readers.

  20. Results of Second Outdoor Comparison Between Absolute Cavity Pyrgeometer (ACP) and Infrared Integrating Sphere (IRIS) Radiometer at PMOD (Presentation)

    SciTech Connect

    Reda, I.; Grobner, J.; Wacker, S.

    2014-01-01

    The Absolute Cavity Pyrgeometer (ACP) and InfraRed Integrating Sphere radiometer (IRIS) are developed to establish a world reference for calibrating pyrgeometers with traceability to SI units. The two radiometers are un-windowed with negligible spectral dependence, and traceable to SI units through the temperature scale (ITS-90). The second outdoor comparison between the two designs was held from September 30 to October 11, 2013 at the Physikalisch-Metorologisches Observatorium Davos (PMOD). The difference between the irradiance measured by ACP and that of the IRIS was within 1 W/m2 (3 IRISs: PMOD + Australia + Germany). From the first and second comparisons, a difference of 4-6 W/m2 was observed between the irradiance measured by ACP&IRIS and that of the interim World Infrared Standard Group (WISG). This presentation includes results from the first and second comparison in an effort to establish the world reference for pyrgeometer calibrations, a key deliverable for the World Meteorological Organization (WMO), and the DOE-ASR.

  1. Structural analysis and interaction studies of acyl-carrier protein (acpP) of Staphylococcus aureus, an extraordinarily thermally stable protein.

    PubMed

    Volk, Kathrin; Breunig, Sven D; Rid, Raphaela; Herzog, Julia; Bräuer, Maria; Hundsberger, Harald; Klein, Christian; Müller, Norbert; Önder, Kamil

    2017-01-01

    Acyl-carrier-protein (acpP) is an essential protein in fatty acid biosynthesis of Staphylococcus aureus [Cronan, J.E. and Thomas, J. (2009). Complex enzymes in microbial natural product biosynthesis, part B: polyketides, aminocoumarins and carbohydrates.

  2. Finger clubbing: do we require digital index quantitator?

    PubMed

    Djojodibroto, R D; Thomas, P T; Kana, K T; Hla, M

    2014-04-01

    Some diseases may underlie finger clubbing. However, there is a dearth of information about early stage of finger clubbing because only few researchers have shown interest in it. We determined the Digital Index of normal, healthy subjects by using thread and manual Vernier calipers, the time used for the procedure, and its interrater reliability. The value of Digital Index was 8.86 ± 0.29 (Mean ± SD) with a range of 8.15 to 9.41. Interrater reliability was excellent with Pearson's correlation coefficient of 0.966. Overall, the time taken to measure the Digital Index ranged from 21.93 to 68.80 minutes with an average of 35.97 ± 9.16 (Mean ± SD). Determining Digital Index need much time, but this can be overcome if we use Digital Index Quantitator (DIQ). Availability of DIQ in the hospital wards will be of much benefit. DIQ can also be used to accurately quantify the progression or regression of the clubbing process. This article proves that we need morphometry of digital clubbing as well as the correlation of the physical sign of clubbing with Digital Index.

  3. Estimating Impact Forces of Tail Club Strikes by Ankylosaurid Dinosaurs

    PubMed Central

    Arbour, Victoria Megan

    2009-01-01

    Background It has been assumed that the unusual tail club of ankylosaurid dinosaurs was used actively as a weapon, but the biological feasibility of this behaviour has not been examined in detail. Ankylosaurid tail clubs are composed of interlocking vertebrae, which form the handle, and large terminal osteoderms, which form the knob. Methodology/Principal Findings Computed tomographic (CT) scans of several ankylosaurid tail clubs referred to Dyoplosaurus and Euoplocephalus, combined with measurements of free caudal vertebrae, provide information used to estimate the impact force of tail clubs of various sizes. Ankylosaurid tails are modeled as a series of segments for which mass, muscle cross-sectional area, torque, and angular acceleration are calculated. Free caudal vertebrae segments had limited vertical flexibility, but the tail could have swung through approximately 100° laterally. Muscle scars on the pelvis record the presence of a large M. longissimus caudae, and ossified tendons alongside the handle represent M. spinalis. CT scans showed that knob osteoderms were predominantly cancellous, which would have lowered the rotational inertia of the tail club and made it easier to wield as a weapon. Conclusions/Significance Large knobs could generate sufficient force to break bone during impacts, but average and small knobs could not. Tail swinging behaviour is feasible in ankylosaurids, but it remains unknown whether the tail was used for interspecific defense, intraspecific combat, or both. PMID:19707581

  4. Journaling: Astronauts Chronicle Missions

    NASA Video Gallery

    Journaling has and will always play an important role in any journey. It’s a simple yet invaluable tool used by behavioral scientists to help assess the mental and emotional states associated with ...

  5. In Other Professional Journals.

    ERIC Educational Resources Information Center

    Campbell, Christine M.

    1992-01-01

    Lists current articles, appearing in major journals on language teaching and learning, applied psycholinguistics, linguistics, curriculum development, computer science, psychology, educational technology, and general education, of particular interest to foreign language instruction professionals. (CB)

  6. Genomic structures and characterization of the 5'-flanking regions of acyl carrier protein and Delta4-palmitoyl-ACP desaturase genes from Coriandrum sativum.

    PubMed

    Kim, Mi Jung; Shin, Jeong Sheop; Kim, Jeong-Kook; Suh, Mi Chung

    2005-09-25

    The seed-specific or seed-predominant promoters of acyl carrier protein (Cs-ACP1) and Delta4-palmitoyl-acyl carrier protein desaturase (Cs-4PAD) genes, which are involved in the biosynthesis of petroselinic acid, were isolated from coriander (Coriandrum sativum) and analyzed in coriander endosperms and transgenic Arabidopsis. The expression of Cs-ACP1 and Cs-4PAD genes was coordinately regulated during seed development.

  7. 27 CFR 31.136 - Change in membership of unincorporated club.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... dissolution of the club and the formation of a new club, unless the changes involve a person with the power to control the management policies or buying or selling practices pertaining to alcohol. In the latter...

  8. What's in Those Boxes Anyway? An Analysis of School Book Club Offerings (Rapid Research Report).

    ERIC Educational Resources Information Center

    Strickland, Dorothy S.; And Others

    1996-01-01

    Investigates the nature and range of materials available through school book clubs in the United States. Finds that the clubs offered a wide range of books that extend beyond contemporary realistic fiction. (SR)

  9. East façade, Burton Park Club House, with Amphitheater in foreground, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    East façade, Burton Park Club House, with Amphitheater in foreground, view to north from Amphitheater stage (90 mm lens). - Burton Park, Club House & Amphitheater, Adjacent ot south end of Chestnut Avenue, San Carlos, San Mateo County, CA

  10. School Astronomy Club: from Project to Knowledge

    NASA Astrophysics Data System (ADS)

    Folhas, Alvaro

    2016-04-01

    Prepare a generation of young people for the challenges of the future is a task which forces us to rethink the school, not just for being difficult, but also because students feel that the school has very little to offer, especially something that interests them. Thus, the school is dysfunctional, is ill, and needs prompt treatment. School have to adjust to the new times, and this does not mean changing the old blackboards by advanced interactive whiteboards. The school has to find the way to the students with something that seduce them: the Challenge. The Astronomy Club that I lead in my school is essentially a Project space. Students who voluntarily joined the club, organize themselves according to their interests around projects whose outcome is not defined from the beginning, which requires them to do, undo and redo. Which obliges them to feel the need to ask for help to mathematics or physics to achieve answers, to feel the passion to study with a genuine purpose of learning. Some examples of the work: The younger students are challenged to reproduce the historical astronomical experiments that have opened the doors of knowledge such as the Eratosthenes experiment to determine the perimeter of the Earth (on equinox), or by using congruent triangles, determine the diameter the sun. These students are driven to establish distance scales in the solar system, which, to their astonishment, allows them to clear misconceptions that arise from some pictures of books and allows them to have a scientifically correct idea of the planetary orbit and distance separating the planets of the Solar System. For students from 15 to 18 years, I have to raise the level of the challenges and use the natural tendency of this age bracket to assert making new and exciting things. To this purpose, I am fortunate to have the support of large organizations like NUCLIO, ESA, CERN, and Go-Lab Project, Inspiring Science Education, Open Discovery Space and Global Hands on Universe. Through

  11. Effects of the SARM ACP-105 on rotorod performance and cued fear conditioning in sham-irradiated and irradiated female mice.

    PubMed

    Dayger, Catherine; Villasana, Laura; Pfankuch, Timothy; Davis, Matthew; Raber, Jacob

    2011-03-24

    Female mice are more susceptible to radiation-induced cognitive changes than male mice. Previously, we showed that, in female mice, androgens antagonize age-related cognitive decline in aged wild-type mice and androgens and selective androgen receptor modulators (SARMs) antagonize cognitive changes induced by human apolipoprotein E4, a risk factor for developing age-related cognitive decline. In this study, the potential effects of the SARM ACP-105 were assessed in female mice that were either sham-irradiated or irradiated with ¹³⁷Cesium at a dose of 10Gy. Behavioral testing started 2 weeks following irradiation. Irradiation impaired sensorimotor function in vehicle-treated mice but not in ACP-105-treated mice. Irradiation impaired cued fear conditioning and ACP-105 enhanced fear conditioning in sham-irradiated and irradiated mice. When immunoreactivity for microtubule-associated protein 2 was assessed in the cortex of sham-irradiated mice, there was a brain area × ACP-105 interaction. While ACP-105 reduced MAP-2 immunoreactivity in the sensorimotor cortex, there was a trend towards increased MAP-2 immunoreactivity in the enthorhinal cortex. No effect on MAP-2 immunoreactivity was seen in the irradiated cortex or sham-irradiated or irradiated hippocampus. Thus, there are relatively early radiation-induced behavioral changes in female mice and reduced MAP-2 levels in the sensorimotor cortex following ACP-105 treatment might contribute to enhanced rotorod performance.

  12. Acyl-ACP thioesterases from castor (Ricinus communis L.): an enzymatic system appropriate for high rates of oil synthesis and accumulation.

    PubMed

    Sánchez-García, Alicia; Moreno-Pérez, Antonio J; Muro-Pastor, Alicia M; Salas, Joaquín J; Garcés, Rafael; Martínez-Force, Enrique

    2010-06-01

    Acyl-acyl carrier protein (ACP) thioesterases are enzymes that terminate the intraplastidial fatty acid synthesis in plants by hydrolyzing the acyl-ACP intermediates and releasing free fatty acids to be incorporated into glycerolipids. These enzymes are classified in two families, FatA and FatB, which differ in amino acid sequence and substrate specificity. In the present work, both FatA and FatB thioesterases were cloned, sequenced and characterized from castor (Ricinus communis) seeds, a crop of high interest in oleochemistry. Single copies of FatA and FatB were found in castor resulting to be closely related with those of Jatropha curcas. The corresponding mature proteins were heterologously expressed in Escherichia coli for biochemical characterization after purification, resulting in high catalytic efficiency of RcFatA on oleoyl-ACP and palmitoleoyl-ACP and high efficiencies of RcFatB for oleoyl-ACP and palmitoyl-ACP. The expression profile of these genes displayed the highest levels in expanding tissues that typically are very active in lipid biosynthesis such as developing seed endosperm and young expanding leaves. The contribution of these two enzymes to the synthesis of castor oil is discussed.

  13. Production and purification of refolded recombinant Plasmodium falciparum beta-ketoacyl-ACP reductase from inclusion bodies.

    PubMed

    Karmodiya, Krishanpal; Srivastav, Ratnesh Kumar; Surolia, Namita

    2005-07-01

    A recombinant form of Plasmodium falciparum beta-ketoacyl-ACP reductase (PfFabG) was overexpressed in Escherichia coli BL-21 codon plus (DE3). The resulting insoluble inclusion bodies were separated from cellular debris by extensive washing with buffer containing 0.05% Tween 20 and solubilized by homogenization with 8 M urea. Attempts to refold PfFabG from solubilized inclusion bodies employing Rotofor (separation based on different pIs of proteins in a mixture) followed by Ni(2+) or cation exchange chromatography were not successful either by bringing down the urea concentration instantaneously, stepwise, or by dialysis. Denatured PfFabG was therefore initially purified by cation exchange chromatography and was then correctly refolded at a final concentration of 100-200 microg/ml in a 20 mM Na-acetate buffer, pH 5.3, with 300 mM NaCl, 10% glycerol, and 0.05% Tween 20. The protein was found to be properly folded only in the presence of the cofactor NADPH and salt at a concentration 300 mM by drop dilution method at 2-8 degrees C for 12 h. The purified final product was >98% pure by denaturing gel electrophoresis. The purified protein was biologically active in a standard enzymatic assay using acetoacetyl-CoA as a substrate. The enzyme was found to be stable up to fourth day of purification and glycerol was found to stabilize enzyme activity for several weeks, during storage. This effort paves the way for elucidation of the structure-function correlations for PfFabG as well as exploration of the enzyme for developing inhibitors against it for combating malaria.

  14. Design of a high perveance ACP gun for the Litton 95 GHz harmonic gyroklystron

    SciTech Connect

    True, R.B.; Bemis, T.M.; Good, G.R.; Scheitrum, G.P.; Higgins, L.L.

    1995-12-31

    This paper describes a new advanced centerpost (ACP) gun for the Litton 95 GHz harmonic gyroklystron which provides roughly four times higher beam current than that available from the original gun. The magnetic focusing structure has been carefully matched to the beam in order to provide a very high quality, low velocity spread, axis-encircling beam. The level of magnetic field in the rf interaction region is consistent with fourth harmonic operation of the device (approximately 8,500 gauss) which allows a conventional solenoid to be used. At an operating voltage of 30 kilovolts and a beam current of 6.4 amps, peak power in the beam from the new gun is 192 kilowatts. At this voltage and current, the perveance of the gun is 1.23 micropervs. Procedures, computer codes, and methodology used to design the gun and magnetic focusing system will be discussed in detail. In design of the magnetic focusing structure, the authors made use of codes POISSON and DEMEOS, in combination with a powerful design method developed by one of the authors (Bemis). The method is based upon Busch`s theorem ;and it will be discussed in the paper. The gun was designed to operate into a .064 inch diameter drift tube for values of {alpha} ranging from 1.2 to 2.0 depending upon the beam voltage. Computed axial velocity spread ({delta}{nu}{sub z}/{nu}{sub z}) achieved so far is just over 2.5 percent which represents an excellent start considering the level of perveance and beam power density. The authors are working to lower this number even further and will report the results of their efforts at the meeting.

  15. Dentinal hypersensitivity: A comparative clinical evaluation of CPP-ACP F, sodium fluoride, propolis, and placebo

    PubMed Central

    Madhavan, Souparna; Nayak, Moksha; Shenoy, Amarnath; Shetty, Rajesh; Prasad, Krishna

    2012-01-01

    Background: Dentine hypersensitivity is a transient condition that often resolves with the natural sclerotic obturation of dentinal tubules. A potent topically applied in-office desensitizing treatment is indicated as the choice of treatment when dentine hypersensitivity is localized to one or two teeth. Aim: The present study aimed to evaluate and compare the clinical efficiency of CPP-ACP F, sodium fluoride, propolis, and distilled water that was used as placebo in treating dentinal hypersensitivity. Materials and Methods: 120 patients aged 20–40 years reporting with dentinal hypersensitivity in relation to canine, premolar and molars with erosion, abrasion, and gingival recession were randomly assigned to four groups of 30 patients each. Response to air jet and tactile stimuli were measured using visual analogue scale initially on 1st, 7th, 15th, 28th, 60th, and final assessment was done on the 90th day. Statistical Analysis: A statistical analysis was done using Anova test (Fischer's test) and Tukey HSD test for multicomparison. Results: The teeth treated with the test group showed decrease in the mean hypersensitivity values compared to control group, over a period of three months. The results showed propolis to be most efficient in treating dentinal hypersensitivity and CPP- ACPF showed to be the least efficient. Conclusion: All test groups were effective in reducing dentinal hypersensitivity, although they differed in rapidity of action over the period of 3 months. Further studies can be done using advanced materials and techniques. Multiple therapeutic modalities have been developed to treat dentinal hypersensitivity including products that impede nerve conduction of pain stimulus, products that mechanically occlude dentinal tubules, and calcium containing products designed to create plugs in the tubules utilizing a demineralization mechanism. PMID:23112475

  16. The 3-hydroxyacyl-ACP dehydratase component of the plant mitochondrial fatty acid synthase system.

    PubMed

    Guan, Xin; Okazaki, Yozo; Lithio, Andrew; Li, Ling; Zhao, Xuefeng; Jin, Huanan; Nettleton, Dan; Saito, Kazuki; Nikolau, Basil J

    2017-02-15

    We report the characterization of the Arabidopsis 3-hydroxyacyl-acyl carrier protein (ACP) dehydratase (mtHD) component of the mitochondrial fatty acid synthase (mtFAS) system, encoded by AT5G60335. The mitochondrial localization and catalytic capability of mtHD were demonstrated with a green fluorescent protein (GFP) transgenesis experiment, and by in vivo complementation and in vitro enzymatic assays. RNAi knockdown lines with reduced mtHD expression exhibit traits typically associated with mtFAS mutants, namely a miniaturized morphological appearance, reduced lipoylation of lipoylated proteins, and altered metabolomes consistent with the reduced catalytic activity of lipoylated enzymes. These alterations are reversed when mthd-rnai mutant plants are grown in a 1% CO2 atmosphere, indicating the link between mtFAS and photorespiratory deficiency due to the reduced lipoylation of glycine decarboxylase. In vivo biochemical feeding experiments illustrate that sucrose and glycolate are the metabolic modulators that mediate the alterations in morphology and lipid accumulation. In addition, both mthd-rnai and mtkas mutants exhibit reduced accumulation of 3-hydroxytetradecanoic acid (i.e. a hallmark of lipid A-like molecules) and abnormal chloroplastic starch granules; these changes are not reversible by the 1% CO2 atmosphere, demonstrating two novel mtFAS functions that are independent of photorespiration. Finally, RNA-Seq analysis revealed that mthd-rnai and mtkas mutants are near equivalent to each other in altering transcriptome, and these analyses further identified genes whose expression is affected by a functional mtFAS system, but independent of photorespiratory deficiency. These data demonstrate the non-redundant nature of the mtFAS system, which contributes unique lipid components needed to support plant cell structure and metabolism.

  17. Job Search Club Program. Program Notebook. Planning/Operations/Leader's Guide.

    ERIC Educational Resources Information Center

    Boys' Clubs of America, New York, NY.

    Guides are provided for planning, operating, and leading a Job Search Club Program. The planning guide for use by club directors, program committees, and club staff presents a cohesive, systematic plan for launching a successful job search program. It offers a step-by-step description of the essential elements of the planning process, an…

  18. Difficulties Faced in Social Club Activities: A Qualitative Study Based on Teacher Opinions

    ERIC Educational Resources Information Center

    Keçe, Murat

    2015-01-01

    The purpose of this study is to scrutinize the problems encountered in social club activities based on opinions of club advisors. This study was conducted in line with qualitative research methods using the interview technique to collect data. Therefore, interviews were held with 21 club advisors included in the study group. A category analysis, a…

  19. Almost All Start but Who Continue? A Longitudinal Study of Youth Participation in Swedish Club Sports

    ERIC Educational Resources Information Center

    Jakobsson, Britta Thedin; Lundvall, Suzanne; Redelius, Karin; Engstrom, Lars-Magnus

    2012-01-01

    Many young people in Sweden stop participating in club sports during their teens, but some continue. Drawing on a longitudinal study, the aim of this article is to highlight some of the characteristics of teenagers who continue with club sports and to discuss the relation between club-sport participation and social and cultural conditions, with…

  20. Raising Money Through Gift Clubs: A Survey of Techniques at 42 Institutions.

    ERIC Educational Resources Information Center

    Sweeney, Robert D., Comp.

    The way that 42 private schools, colleges, and universities use gift clubs to motivate donors is examined. Based on a nationwide survey, information is presented on the clubs' origins, requirements for membership, methods of enlisting new members, and ways of encouraging current members to increase gifts. Attention is also directed to the clubs'…

  1. Making Every Day Count: Boys & Girls Clubs' Role in Promoting Positive Outcomes for Teens

    ERIC Educational Resources Information Center

    Arbreton, Amy

    2009-01-01

    The third in a series of reports from P/PV's three-year study of the role Boys & Girls Clubs play in the lives of the youth they serve, "Making Every Day Count" examines how Club participation is related to youth's positive and healthy development in three outcome areas identified by Boys & Girls Clubs of America as central to its mission: good…

  2. Coaches' Perceptions of French Sports Clubs: Health-Promotion Activities, Aims and Coach Motivation

    ERIC Educational Resources Information Center

    Van Hoye, Aurélie; Sarrazin, Philippe; Heuzé, Jean-Philippe; Kokko, Sami

    2015-01-01

    Background: Given the benefits of participating in sport, sports clubs have been recognised as health promoting organizations. To examine health-promotion activities in Finnish sports clubs, Kokko et al. developed a set of standards for health-promoting sports clubs (HPSC). Objective: The present study extends this line of research, by (1)…

  3. An Academic Club Service Learning Project as a Demonstration of Experiential Teaching Tools

    ERIC Educational Resources Information Center

    Bonczek, James L.; Snyder, Lori Unruh; Ellis, Larry R.

    2007-01-01

    We describe our pedagogical approaches and experiences with an academic club service learning project (one semester, 20 club participants, including both graduate students and lower and upper-level undergraduates). Our service learning project responds to the recent demand for more community service-based club projects within the College of…

  4. Charismatic Cops, Patriarchs and a Few Good Women: Leadership, Club Culture and Young Peoples' Drinking

    ERIC Educational Resources Information Center

    Kelly, Peter; Hickey, Chris; Cormack, Sue; Harrison, Lyn; Lindsay, Jo

    2011-01-01

    The paper reports on key findings of a research project that examined the roles that community-based sporting clubs in the Australian state of Victoria play in shaping young people's understandings and uses of alcohol. Our research imagined clubs as community hubs that are located in complex networks that impact on the ways that clubs understand…

  5. 7 CFR 795.10 - Club, society, fraternal or religious organization.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 7 2013-01-01 2013-01-01 false Club, society, fraternal or religious organization... General § 795.10 Club, society, fraternal or religious organization. Each individual club, society..., society, fraternal or religious organization is engaged in the production of crops as a separate...

  6. 7 CFR 795.10 - Club, society, fraternal or religious organization.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 7 2014-01-01 2014-01-01 false Club, society, fraternal or religious organization... General § 795.10 Club, society, fraternal or religious organization. Each individual club, society..., society, fraternal or religious organization is engaged in the production of crops as a separate...

  7. 7 CFR 795.10 - Club, society, fraternal or religious organization.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 7 2012-01-01 2012-01-01 false Club, society, fraternal or religious organization... General § 795.10 Club, society, fraternal or religious organization. Each individual club, society..., society, fraternal or religious organization is engaged in the production of crops as a separate...

  8. 7 CFR 795.10 - Club, society, fraternal or religious organization.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Club, society, fraternal or religious organization... General § 795.10 Club, society, fraternal or religious organization. Each individual club, society..., society, fraternal or religious organization is engaged in the production of crops as a separate...

  9. 7 CFR 795.10 - Club, society, fraternal or religious organization.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 7 2011-01-01 2011-01-01 false Club, society, fraternal or religious organization... General § 795.10 Club, society, fraternal or religious organization. Each individual club, society..., society, fraternal or religious organization is engaged in the production of crops as a separate...

  10. Toward an Ecstasy and Other Club Drug (EOCD) Prevention Intervention for Rave Attendees

    ERIC Educational Resources Information Center

    Yacoubian, George S., Jr.; Miller, Sarah; Pianim, Selwyn; Kunz, Michael; Orrick, Erin; Link, Tanja; Palacios, Wilson R.; Peters, Ronald J.

    2004-01-01

    A growing body of recent research has identified that "rave" attendees are at high risk for the use of "club drugs," such as 3,4-methylenedioxymeth-amphetamine (MDMA or "ecstasy"). Rave attendees, however, comprise only one of several club-going populations. In the current study, we explore the prevalence of ecstasy and other club drug (EOCD) use…

  11. The Clubbers' Guide: New Academic Year, New Science/STEM Club?

    ERIC Educational Resources Information Center

    Scott, Linda; Howarth, Sue

    2011-01-01

    In this article, the authors present some ideas to help one start (or continue) a successful science/STEM club. Some "tips" are given by Mike Bullock, a teacher from the West Midlands, who set up a STEM club after his NQT (newly qualified teacher) year and whose club members went on to do well in the STEM Challenges. Information is provided about…

  12. The Supernova Club: Urban Youth Engagement that Works

    NASA Astrophysics Data System (ADS)

    Sakimoto, Philip J.; Luckey, V.; Balsara, D.

    2008-05-01

    One of IYA's goals is to promote greater involvement by underrepresented minorities in scientific and engineering careers. IYA can serve as a catalyst for such involvement, but ultimate success requires a longer-term approach. The Supernova Club is an experiment in such a long-term approach. The goal is to see if engagement in a year-round astronomy club can propel youths from some of the most severely disadvantaged areas of our region into careers in science. We recruited club members by bringing astronomy activities to over a hundred youths ages 10-16 who were on campus in Summer 2007 for Notre Dames’ National Youth Sports Program (NYSP). Approximately 20 percent of the participants, most of who were underrepresented minorities and from below poverty level, expressed interest in joining an after-school astronomy club, and thirteen of them ultimately did so. The club meets one evening a week at Notre Dame's Robinson Community Learning Center. Center staff provide extensive support with logistics, meals, training in social skills and conduct, and communications with parents. Notre Dame scientists, assisted by local teachers, provide weekly activities. After one year, the club members have shown large improvements in interest in science and astronomy, ability to focus on tasks or discussions, and general behavior at school and at home. Funding for this first pilot year was provided through education supplements to HST research grants. With NASA space science education funding currently on an indefinite stand down, we are seeking other funds with which to carry on this experiment.

  13. Citation Indicators of Japanese Journals.

    ERIC Educational Resources Information Center

    Haiqi, Zhang; Yamazaki, Shigeaki

    1998-01-01

    Evaluates Japanese journals--128 indexed in the 1994 "Journal Citation Reports"--in bibliometric parameters such as impact factors (IFs), mean IFs from citing and cited journals, and self-citing and self-cited rates. Results: only 15 journals, with a wide variation of self-citing and self-cited rates, have obtained a current impact…

  14. Method of transportation and drinking among club patrons

    PubMed Central

    Bourdeau, Beth; Miller, Brenda A.; Johnson, Mark B.; Voas, Robert B.

    2015-01-01

    Objective The current study examines the variation in alcohol use among nightclub patrons under three transportation conditions: those who departed from a club using modes of transportation other than cars or motorcycles (e.g., pedestrians, bicyclists, subway riders); those who were passengers of drivers (auto/taxi passenger patrons); and those who drove from the club (driving patrons). We seek to determine whether patrons' choice for how to leave the club contributes to their risk, as assessed by blood alcohol concentrations (BAC), after controlling for other factors that may contribute to their BAC including demographic characteristics and social drinking group influences. Methods Data were collected from social drinking groups as they entered and exited clubs for 71 different evenings at ten clubs from 2010 through 2012. Using portal methodology, a research site was established proximal to club entrances. Each individual participant provided data on themselves and others in their group. The present analyses are based upon 1833 individuals who completed both entrance and exit data. Our outcome variable is blood alcohol content (BAC) based upon breath tests attained from patrons at entrance and exit from the club. Independent variables include method of transportation, social group characteristics, drug use, and personal characteristics. We use step-wise multiple regressions to predict entrance BAC, change in BAC from entrance to exit, and exit BAC: first entering individual demographic characteristics, then entering group characteristics, then drug use, and finally entering method of transportation (two dummy coded variables such that drivers are the referent category). Results In sum, in all three of our analyses, only three variables are consistently predictive of BAC: presence of a group member who is frequently drunk and non-driving modes of transportation, either being the passenger or taking alternate methods of transportation. In particular, taking an

  15. The professionalization of Carl G. Jung's analytical psychology clubs.

    PubMed

    Samuels, A

    1994-04-01

    This paper addresses (1) the history of a cluster of unusual institutions-analytical psychology clubs--which started in 1916 and by 1934 had become established in many of the countries in the world in which there was interest in the analytical psychology of Carl G. Jung; (2) the conflicts involved in trying to unite the relatively informal earlier "Jung Clubs" with the more formal societies being established by the increasing numbers of professionally trained analysts; and (3) the wider cultural and social issues included in the professionalization of analytical psychology.

  16. Book clubs--outreach opportunities for hospital libraries.

    PubMed

    Stephenson, Priscilla L; Clever, Shannon; Coady, Teresa R; Ender, Deniz; Heyd, Michael; Peth, Sara

    2014-01-01

    Book clubs and discussion groups provide opportunities for hospital librarians to reach out to staff from all areas of their facilities while introducing them to literature reflecting participants' personal and professional interests. Librarians presenting these case studies have coordinated local book clubs where topics ranged from titles about the nature of healing, to leadership development, and patient-centered care. Some also included contemporary novels of interest to participants. No matter the setting or scope of material discussed, each group has provided unique networking opportunities for staff to meet others working in various departments of their facilities.

  17. Performance of Malaysian Medical Journals.

    PubMed

    Abrizah, Abdullah

    2016-03-01

    Indexation status matters for scholarly journal prestige and trust. The performance of Malaysian medical journals at the international level is gauged through the global citation databases, and at the national level through MyCite, a national citation indexing system. The performance indicators include journals publication productivity, the citations they garner, and their scores on other bibliometric indices such as journal impact factor (IF), and h-index. There is a growing consciousness amongst journal editorials to improve quality and increase chances of getting indexed in MyCite. Although it is now possible to gauge journal performance within Malaysia, through MyCite, the government and public are concerned about journal performance in international databases. Knowing the performance of journals in MyCite will help the editors and publishers to improve the quality and visibility of Malaysian journals and strategise to bring their journal to the international level of indexation.

  18. Performance of Malaysian Medical Journals

    PubMed Central

    Abrizah, Abdullah

    2016-01-01

    Indexation status matters for scholarly journal prestige and trust. The performance of Malaysian medical journals at the international level is gauged through the global citation databases, and at the national level through MyCite, a national citation indexing system. The performance indicators include journals publication productivity, the citations they garner, and their scores on other bibliometric indices such as journal impact factor (IF), and h-index. There is a growing consciousness amongst journal editorials to improve quality and increase chances of getting indexed in MyCite. Although it is now possible to gauge journal performance within Malaysia, through MyCite, the government and public are concerned about journal performance in international databases. Knowing the performance of journals in MyCite will help the editors and publishers to improve the quality and visibility of Malaysian journals and strategise to bring their journal to the international level of indexation. PMID:27547108

  19. The Club of Rome and its computer.

    PubMed

    Chase, S

    1973-03-01

    When the Club of Rome, an assemblage of 75 scientists and businessmen gathered to study the ''predicament of mankind in the face of technology growing at an exponential rate,'' issued its computer study it launched a battle between proponents of gross national product and those favoring quality of life. The computer simulation studied the interaction of population growth, food supply, inductrial production, resource use, and pollution under varying conditions. It concluded that our industrial system is headed for too many people in relation to food and living space, too much production in relation to natural resources, and for too much pollution. This will affect all countries. The traditional economists say the continued growth of the gross national product is the only way to ensure better living conditions while the ecologists point out that quality of life is being destroyed. The author cites arguments both for and against the quality-of-life view. The problem is that continued industrial growth creates wants as well as satisfying them and leads to waste as well as needful consumption. John Stuart Mill stated 100 years ago that the world could not support continued technological expansion and society must reach an equilibrium. 8 steps must be taken if the planet is to reach such an equilibrium, which is essential to the survival of all: 1) a zero rate of population growth, although there may be variations between countries with some over and some under; 2) a zero rate of industrial output with overall new investment equal to overall rate of industrial depreciation; 3) a policy of recycling and conserving material resources; 4) an adequate budget of food, shelter, clothing, health services, and education for every human being (a budget which does not allow for autos and air conditioning); 5) a sharp decline in consumption of material goods in affluent societies with a corresponding shift to more services and an increase in material goods for low energy societies

  20. 33 CFR 165.906 - Lakeside Yacht Club in Cleveland Harbor, Cleveland, OH-regulated navigation areas.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Club entrance channel,” defined as the water area between the Lakeside Yacht Club jetties and the Burke... no. 1. Restricted area no. 1 is the water area on the southwest end of the Lakeside Yacht Club...) Restricted area no. 2. Restricted area no. 2 is the water area of the Lakeside Yacht Club entrance...

  1. 33 CFR 165.906 - Lakeside Yacht Club in Cleveland Harbor, Cleveland, OH-regulated navigation areas.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Club entrance channel,” defined as the water area between the Lakeside Yacht Club jetties and the Burke... no. 1. Restricted area no. 1 is the water area on the southwest end of the Lakeside Yacht Club...) Restricted area no. 2. Restricted area no. 2 is the water area of the Lakeside Yacht Club entrance...

  2. 20 CFR 404.1014 - Domestic service by a student for a local college club, fraternity or sorority.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... college club, fraternity or sorority. 404.1014 Section 404.1014 Employees' Benefits SOCIAL SECURITY... a local college club, fraternity or sorority. (a) General. If you are a student and do work of a household nature in or about the club rooms or house of a local college club or local chapter of a...

  3. 20 CFR 404.1014 - Domestic service by a student for a local college club, fraternity or sorority.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... college club, fraternity or sorority. 404.1014 Section 404.1014 Employees' Benefits SOCIAL SECURITY... a local college club, fraternity or sorority. (a) General. If you are a student and do work of a household nature in or about the club rooms or house of a local college club or local chapter of a...

  4. 20 CFR 404.1014 - Domestic service by a student for a local college club, fraternity or sorority.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... college club, fraternity or sorority. 404.1014 Section 404.1014 Employees' Benefits SOCIAL SECURITY... a local college club, fraternity or sorority. (a) General. If you are a student and do work of a household nature in or about the club rooms or house of a local college club or local chapter of a...

  5. 20 CFR 404.1014 - Domestic service by a student for a local college club, fraternity or sorority.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... college club, fraternity or sorority. 404.1014 Section 404.1014 Employees' Benefits SOCIAL SECURITY... a local college club, fraternity or sorority. (a) General. If you are a student and do work of a household nature in or about the club rooms or house of a local college club or local chapter of a...

  6. 20 CFR 404.1014 - Domestic service by a student for a local college club, fraternity or sorority.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... college club, fraternity or sorority. 404.1014 Section 404.1014 Employees' Benefits SOCIAL SECURITY... a local college club, fraternity or sorority. (a) General. If you are a student and do work of a household nature in or about the club rooms or house of a local college club or local chapter of a...

  7. Comparison of Coaches' Perceptions and Officials Guidance towards Health Promotion in French Sport Clubs: A Mixed Method Study

    ERIC Educational Resources Information Center

    Van Hoye, A.; Heuzé, J.-P.; Larsen, T.; Sarrazin, P.

    2016-01-01

    Despite the call to improve health promotion (HP) in sport clubs in the existing literature, little is known about sport clubs' organizational capacity. Grounded within the setting-based framework, this study compares HP activities and guidance among 10 football clubs. At least three grassroots coaches from each club (n = 68) completed the Health…

  8. A Cross-Cultural Study on Meaning and the Nature of Children's Experiences in Australian and French Swimming Clubs

    ERIC Educational Resources Information Center

    Light, Richard

    2010-01-01

    This article reports on a study conducted in Australia and France that inquired into the meaning and the nature of children's experiences of being in swimming clubs with a focus on the positive aspects of membership that keep them in their clubs. Three-month long case studies were conducted in a club in Australia and in a club in France, employing…

  9. In situ Effect of Chewing Gum with and without CPP-ACP on Enamel Surface Hardness Subsequent to ex vivo Acid Challenge.

    PubMed

    Jordão, M C; Alencar, C R B; Mesquita, I M; Buzalaf, M A R; Magalhães, A C; Machado, M A A M; Honório, H M; Rios, D

    2016-01-01

    The erosion-protective effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) is controversial. This study aimed to investigate the ability of CPP-ACP chewing gum to prevent a single event of erosive demineralization in situ. Bovine enamel blocks (n = 120) were randomly assigned to 3 phases according to the baseline surface hardness: phase I (PI) - chewing gum with CPP-ACP, phase II (PII) - chewing gum without CPP-ACP, and control phase (PIII) - salivary effect without stimulation (no gum). Nineteen volunteers participated in this study during 3 crossover phases of 2 h. In PI and PII, the volunteers wore intraoral palatal appliances for 120 min and chewed a unit of the corresponding chewing gum for the final 30 min. In the control phase the volunteers wore the appliance for 2 h, without chewing gum. Immediately after intraoral use, the appliances were extraorally immersed in a cola drink for 5 min to promote erosive demineralization. The percentage of surface hardness loss was calculated. The data were analyzed by ANOVA models and Tukey's test. Lower enamel hardness loss was found after the use of chewing gum with CPP-ACP (PI: 32.7%) and without CPP-ACP (PII: 33.5%) compared to the salivary effect without stimulation (PIII: 39.8%) (p < 0.05). There was no difference between PI and PII (p > 0.05). The results suggest that the use of chewing gum immediately before an erosive demineralization can diminish enamel hardness loss. However, the presence of CPP-ACP in the chewing gum cannot enhance this protective effect.

  10. Effect of CPP-ACP on the remineralization of acid-eroded human tooth enamel: nanomechanical properties and microtribological behaviour study

    NASA Astrophysics Data System (ADS)

    Zheng, L.; Zheng, J.; Zhang, Y. F.; Qian, L. M.; Zhou, Z. R.

    2013-10-01

    Casein phosphopeptide-stabilized amorphous calcium phosphate (CPP-ACP) has been used to enhance tooth remineralization in the dental clinic. But the contribution of CPP-ACP to the remineralization of acid-eroded human tooth enamel is of widespread controversy. To confirm the application potential of CPP-ACP in the remineralization repair of tooth erosion caused by acid-attack, the effect of remineralization in vitro in 2% w/v CPP-ACP solution on the acid-eroded human tooth enamel was investigated in this study. The repair of surface morphology and the improvement of nanomechanical and microtribological properties were characterized with laser confocal scanning microscope, scanning electron microscope, nanoindentation tester and nanoscratch tester. Results showed that a layer of uneven mineral deposits, which were mainly amorphous calcium phosphate (ACP) in all probability, was observed on the acid-eroded enamel surface after remineralization. Compared with the acid-eroded enamel surface, the nanoindentation hardness and Young's modulus of the remineralized enamel surface obviously increased. Both the friction coefficient and wear volume of the acid-eroded enamel surface decreased after remineralization. However, both the nanomechanical and the anti-wear properties of the remineralized enamel surface were still inferior to those of original enamel surface. In summary, tooth damage caused by acid erosion could be repaired by remineralization in CPP-ACP solution, but the repair effect, especially on the nanomechanical and anti-wear properties of the acid-eroded enamel, was limited. These results would contribute to a further exploration of the remineralization potential of CPP-ACP and a better understanding of the remineralization repair mechanism for acid-eroded human tooth enamel.

  11. Significant journals of science.

    PubMed

    Garfield, E

    1976-12-16

    In 1974 the Science Citation Index (SCI) covered about 401,000 articles and communications in 2,443 scientific and technical journals. They cited about 3.2 million different publications an average of 1.8 times each. In this article some results of an analysis of more than 5 million citations in the references of journal articles indexed for the SCI in 1974 are presented and an attempt is made to interpret of those results in the light of an earlier study of 1969 citations.

  12. Targeting the right journal.

    PubMed

    Piterman, L; McCall, L

    1999-07-01

    While research is scientific, publication is a mixture of science and political pragmatism. Targeting the right journal is influenced by the following factors: the discipline that best represents the subject; the purpose of the message; the audience who are to be recipients of the message; the realities of geographic parochialism; the desire of authors to maximise personal and professional opportunities. If the originally targeted journal rejects the article, authors should have alternative publication strategies that give them professional recognition without requiring them to compromise the message or their ethics.

  13. Club-based and non-club-based physiotherapists' views on the psychological content of their practice when treating sports injuries.

    PubMed

    Lafferty, M E; Kenyon, R; Wright, C J

    2008-01-01

    The aim of the present study was to explore whether there were any differences in the psychological content of practice between club-contracted and non-club-contracted physiotherapists when treating sports injuries. Eighty-seven certified physiotherapists (non-club contracted N = 42, club contracted N = 45) from the United Kingdom completed a modified version of the Athletic Training and Sport Psychology Questionnaire (ATSPQ). Results revealed significant between-group differences in psychological skills use and the importance of psychological skills knowledge. Non-club-contracted physiotherapists reported a higher use of improving social support and higher-order psychological skills (e.g., reducing depression, stress, and anxiety) and rated knowledge of these psychological skills to be more important whilst club-contracted physiotherapists reported a higher use of short-term goal settings. These findings suggest that non-club-based physiotherapists may approach the treatment of injured athletes in a different way to their club-based counterparts. Results suggest athletes treated outside of the club system may experience a different recovery process.

  14. The impact of alcohol management practices on sports club membership and revenue.

    PubMed

    Wolfenden, L; Kingsland, M; Rowland, B; Dodds, P; Sidey, M; Sherker, S; Wiggers, J

    2016-04-13

    Issue addressed: The aim of this study was to assess the impact of an alcohol management intervention on community sporting club revenue (total annual income) and membership (number of club players, teams and spectators).Methods: The study employed a cluster randomised controlled trial design that allocated clubs either an alcohol accreditation intervention or a control condition. Club representatives completed a scripted telephone survey at baseline and again ~3 years following. Demographic information about clubs was collected along with information about club income.Results: Number of players and senior teams were not significantly different between treatment groups following the intervention. The intervention group, however, showed a significantly higher mean number of spectators. Estimates of annual club income between groups at follow-up showed no significant difference in revenue.Conclusions: This study found no evidence to suggest that efforts to reduce alcohol-related harm in community sporting clubs will compromise club revenue and membership.So what?: These findings suggest that implementation of an intervention to improve alcohol management of sporting clubs may not have the unintended consequence of harming club viability.

  15. Boys and Girls Clubs in Public Housing. Final Research Report.

    ERIC Educational Resources Information Center

    Pope, Carl E.; And Others

    This report presents findings and recommendations resulting from the evaluation of programs implemented in 15 cities by the Boys and Girls Clubs of America. These programs were implemented to distribute variations on the "Weed and Seed" program and its provision of crime and drug prevention programs. The overall goal of Weed and Seed was…

  16. The Environmental Message of Audubon and the Sierra Club Bulletin

    ERIC Educational Resources Information Center

    Hoesterey, John; Bowman, James S.

    1976-01-01

    This study attempted to determine the impact of environmental values on two periodicals: Audubon and the Sierra Club Bulletin. The two periodicals were analyzed for the period 1969-1974. Many conclusions are presented including that the Audubon Society may be undergoing an organizational change by becoming more politically oriented. (BT)

  17. Engaging Teens in Recreational Reading through Book Clubs

    ERIC Educational Resources Information Center

    Heard, Jil'Lana

    2015-01-01

    Being concerned about the decline in recreational reading among adolescent students, with several colleagues, the author began brainstorming ideas on how to better promote reading. One of the ideas that kept recurring was hosting a book club for students. Since the focus would be on reintroducing the idea of reading for pleasure and not just for…

  18. Teens, Crime, and the Community in Boys & Girls Clubs.

    ERIC Educational Resources Information Center

    Carlson, Andrea

    Teens, Crime, and the Community (TCC) curriculum creates an awareness among teens of the crime problems facing our communities and how they affect our nation. It encourages youth to take responsibility for reducing crime and victimization, making schools and neighborhoods safer. Boys and Girls Clubs offer a variety of programs for youth, and TCC…

  19. Marshall Amateur Radio Club experiment (MARCE) post flight data analysis

    NASA Technical Reports Server (NTRS)

    Rupp, Charles C.

    1987-01-01

    The Marshall Amateur Radio Club Experiment (MARCE) data system, the data recorded during the flight of STS-61C, the manner in which the data was reduced to engineering units, and the performance of the student experiments determined from the data are briefly described.

  20. Inducting an Eighth Grader into the Literacy Club.

    ERIC Educational Resources Information Center

    Daniel, Patricia L.

    1996-01-01

    Explains how a teacher uses a mystery novel and an aesthetic approach to literature appreciation, as opposed to one concerned with facts in the text, to engage students and prep them for writing their own mystery stories. Shows how one student in particular overcame her sense of exclusion and felt a part of the "literacy club." (TB)

  1. The Hip-Hop club scene: Gender, grinding and sex.

    PubMed

    Muñoz-Laboy, Miguel; Weinstein, Hannah; Parker, Richard

    2007-01-01

    Hip-Hop culture is a key social medium through which many young men and women from communities of colour in the USA construct their gender. In this study, we focused on the Hip-Hop club scene in New York City with the intention of unpacking narratives of gender dynamics from the perspective of young men and women, and how these relate to their sexual experiences. We conducted a three-year ethnographic study that included ethnographic observations of Hip-Hop clubs and their social scene, and in-depth interviews with young men and young women aged 15-21. This paper describes how young people negotiate gender relations on the dance floor of Hip-Hop clubs. The Hip-Hop club scene represents a context or setting where young men's masculinities are contested by the social environment, where women challenge hypermasculine privilege and where young people can set the stage for what happens next in their sexual and emotional interactions. Hip-Hop culture therefore provides a window into the gender and sexual scripts of many urban minority youth. A fuller understanding of these patterns can offer key insights into the social construction of sexual risk, as well as the possibilities for sexual health promotion, among young people in urban minority populations.

  2. Transnational Alliances: "La Clase Mágica--Nepohualtzitzin" Ethnomathematics Club

    ERIC Educational Resources Information Center

    Prieto, Linda; Claeys, Lorena; González, Everardo Lara

    2015-01-01

    This article exposes the ancient "Nepohualtzitzin" as an important contemporary mathematical tool. The design and development of "Nepohualtzitzin" Ethnomathematics Clubs (NECs) in predominantly Latina/o and low-income schools is also presented. NECs provide informal learning opportunities to develop and strengthen cultural…

  3. Using Digital Classrooms to Conduct 4-H Club Meetings

    ERIC Educational Resources Information Center

    West, Patricia; Fuhrman, Nicholas E.; Morgan, A. Christian; Duncan, Dennis W.

    2012-01-01

    Using computer technology and digital classrooms to conduct 4-H Club meetings is an efficient way to continue delivering quality 4-H programming during times of limited resources and staff. Nineteen Junior and Senior 4-H'ers participated in seven digital classroom workshops using the Wimba Classroom application. These digital classroom sessions…

  4. Registration of “Pritchett” soft white winter club wheat

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Soft white club winter wheat (Triticium aestivum L. ssp. compactum) is a unique component of the wheat production in the PNW, comprising 6-10% of the wheat crop. It is valued for milling and baking functionality and marketed for export in a 20-30% blend with soft white wheat as Western White. Our g...

  5. Magical Mysteries. Texas Reading Club, 1984. A Librarian's Planning Handbook.

    ERIC Educational Resources Information Center

    Oliver, Jim

    Designed to encourage library use by Texas youth, the Texas Reading Club programs usually include a structured reading program and a variety of entertaining literature-related storyhours, puppet shows, films, and other attractive happenings. This handbook for the 1984 theme--"magical mysteries"--focuses on mysteries, magic, and adventure…

  6. Sports Club Development--The '70'S Community Involvement.

    ERIC Educational Resources Information Center

    Juncker, D. F.

    A large-scale movement toward sports clubs is evolving in colleges and universities in response to widespread professionalism in varsity sports, limited sports opportunities available to highly skilled student athletes, and most importantly, substantial increases in the desire for sports participation by students in general, as a supplement to…

  7. 8. INTERIOR VIEW OF CLUB HOUSE BEDROOM ON SOUTHEAST CORNER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. INTERIOR VIEW OF CLUB HOUSE BEDROOM ON SOUTHEAST CORNER OF HOTEL. BOAT HOUSE AND DOCK VISIBLE FROM WINDOW ON LEFT; SWAN FALLS POWER HOUSE AND CONSTRUCTION SITE VISIBLE FROM WINDOW ON RIGHT. CAMERA FACING WEST/NORTHWEST. - Swan Falls Village, Clubhouse 011, Snake River, Kuna, Ada County, ID

  8. Argonne Director Eric Isaacs addresses the National Press Club

    SciTech Connect

    Eric Isaccs

    2009-09-17

    Argonne Director Eric Isaacs addresses the National Press Club on 9/15/2009. To build a national economy based on sustainable energy, the nation must first "reignite its innovation ecology," he said. Issacs makes the case for investing in science to secure America's future.

  9. 17. Interior of upper level (Turf Club level) of south ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. Interior of upper level (Turf Club level) of south and west additions to the Clubhouse. Camera pointed W. Stairs in foreground lead to the 'Gallery' room. Stairs in background lead to the 'Callahan' room. 'Broderick' room (not shown) is entered from south side of 'Gallery' room. (July 1993) - Longacres, Clubhouse & Additions, 1621 Southwest Sixteenth Street, Renton, King County, WA

  10. Library-Based Summer Reading Clubs: Who Participates and Why?

    ERIC Educational Resources Information Center

    Justice, Laura M.; Piasta, Shayne B.; Capps, Janet L.; Levitt, Stephanie R.

    2013-01-01

    This article reports on a research study designed to identify who participates in library-based summer reading clubs (SRCs) and why they elect to do so. To address this aim, questionnaires were completed by caregivers of 246 children upon enrollment to the SRC of a metropolitan library as well as 480 youth; the questionnaire was designed to learn…

  11. Bullying 101: The Club Crew's Guide to Bullying Prevention

    ERIC Educational Resources Information Center

    PACER Center, 2013

    2013-01-01

    "Bullying 101" is the Club Crew's Guide to Bullying Prevention. A visually-friendly, age-appropriate, 16-page colorful guide for students to read or for parents to use when talking with children, this guide describes and explains what bullying is and is not, the roles of other students, and tips on what each student can do to prevent…

  12. The Morehouse College Glee Club: History and Recent Highlights.

    ERIC Educational Resources Information Center

    Morrow, David

    1987-01-01

    The history of the Morehouse College Glee Club, founded around 1911 at the Black college, is highlighted by appearances before such notables as Franklin D. Roosevelt, Martin Luther King, Jr., Haile Selassie, Jimmy Carter, and Benjamin E. Mays and performances with people such as Robert Shaw, Leontyne Price, Diahann Carroll, Maynard Jackson, Billy…

  13. Bears, Trolls, and Pagemasters: Learning about Learners in Book Clubs.

    ERIC Educational Resources Information Center

    Frank, Carolyn R.; Dixon, Carol N.; Brandts, Lois R.

    2001-01-01

    Illustrates how in one particular second-grade classroom students had opportunities for learning the academic and social content of literature while simultaneously engaging in the processes and practices of reading. Focuses on the kinds of opportunities offered to students in their involvement in Book Clubs and how those opportunities occur when…

  14. Kids Food CyberClub. Teacher's Guide. First Edition.

    ERIC Educational Resources Information Center

    Belyea, Monica

    This guide is designed to help teachers educate students to be healthier now and in the future. It presents fun, learner-centered activities about nutrition, food, hunger, and food sources. It offers an overview of each section of the Kids Food CyberClub web site, and classroom activities teachers can use to expand on information students will…

  15. Change Agent Research for Windsor Aquatic Club (CAR/WAC).

    ERIC Educational Resources Information Center

    Moriarty, Dick; Olafson, Gord

    This study of the Windsor Aquatic Club (WAC) was undertaken to investigate the following problems and questions: (a) identification of goals; (b) conflict in the interface of age class and school class swimming, as well as the interface of municipal, regional, provincial, federal, and international organizations; (c) identification of task,…

  16. Argonne Director Eric Isaacs addresses the National Press Club

    ScienceCinema

    Eric Isaccs

    2016-07-12

    Argonne Director Eric Isaacs addresses the National Press Club on 9/15/2009. To build a national economy based on sustainable energy, the nation must first "reignite its innovation ecology," he said. Issacs makes the case for investing in science to secure America's future.

  17. Tracking Club Sport Participation from Childhood to Early Adulthood

    ERIC Educational Resources Information Center

    Richards, Rosalina; Williams, Sheila; Poulton, Richie; Reeder, Anthony I.

    2007-01-01

    This study examined the strength of tracking sport participation from childhood to early adulthood among the Dunedin Multidisciplinary Health and Development Study cohort. Participation in sport, dance, or gymnastics as part of a club or group (outside of school) was assessed at ages 7, 9, 15, 18, and 21 years. In addition to the traditionally…

  18. Extracurricular School Clubs: A Time for Fun and Learning

    ERIC Educational Resources Information Center

    Pence, Alicia R.; Dymond, Stacy K.

    2015-01-01

    Inclusion in school clubs affords students with severe disabilities learning opportunities as well as a natural context for addressing curricula. These learning opportunities expand the number of settings in which students can practice, master, and generalize skills associated with priority IEP objectives. Teaching skills within natural activities…

  19. "Space Capers." Texas Reading Club 1982: A Librarian's Planning Handbook.

    ERIC Educational Resources Information Center

    Rudd, Peggy Jemelka

    Originally designed as a summer program to be offered through the network of bookmobiles and rural public libraries in the state, the Texas Reading Club is now also promoted year round by school and institutional libraries to encourage young readers and to acquaint them with libraries and their services. A theme, formats and ideas, and basic…

  20. Imaginary Indians: Representations of Native Americans in Scholastic Reading Club

    ERIC Educational Resources Information Center

    Chaudhri, Amina; Schau, Nicole

    2016-01-01

    Scholastic Reading Clubs are a popular and inexpensive way for teachers to build classroom libraries and for parents to purchase books for their children. The books made accessible to children through the order forms are assumed to be suitable for young readers in terms of their content, popularity, currency, and curricular relevance.…

  1. Comparison of SCImago journal rank indicator with journal impact factor.

    PubMed

    Falagas, Matthew E; Kouranos, Vasilios D; Arencibia-Jorge, Ricardo; Karageorgopoulos, Drosos E

    2008-08-01

    The application of currently available sophisticated algorithms of citation analysis allows for the incorporation of the "quality" of citations in the evaluation of scientific journals. We sought to compare the newly introduced SCImago journal rank (SJR) indicator with the journal impact factor (IF). We retrieved relevant information from the official Web sites hosting the above indices and their source databases. The SJR indicator is an open-access resource, while the journal IF requires paid subscription. The SJR indicator (based on Scopus data) lists considerably more journal titles published in a wider variety of countries and languages, than the journal IF (based on Web of Science data). Both indices divide citations to a journal by articles of the journal, during a specific time period. However, contrary to the journal IF, the SJR indicator attributes different weight to citations depending on the "prestige" of the citing journal without the influence of journal self-citations; prestige is estimated with the application of the PageRank algorithm in the network of journals. In addition, the SJR indicator includes the total number of documents of a journal in the denominator of the relevant calculation, whereas the journal IF includes only "citable" articles (mainly original articles and reviews). A 3-yr period is analyzed in both indices but with the use of different approaches. Regarding the top 100 journals in the 2006 journal IF ranking order, the median absolute change in their ranking position with the use of the SJR indicator is 32 (1st quartile: 12; 3rd quartile: 75). Although further validation is warranted, the novel SJR indicator poses as a serious alternative to the well-established journal IF, mainly due to its open-access nature, larger source database, and assessment of the quality of citations.

  2. The CATESOL Journal, 2001.

    ERIC Educational Resources Information Center

    Brinton, Donna, Ed.; Ching, Roberta, Ed.

    2001-01-01

    This journal contains the following articles: "Teachers' Perceptions of the Supports and Resources Needed to Prepare English Language Learners for the Future" (Douglas Fisher); "Exploring the Learning Styles of Russian-Speaking Students of English as a Second Language" (Ann C. Wintergerst and Andrea DeCapua); "New Voices…

  3. Brazilian History through Journalism.

    ERIC Educational Resources Information Center

    Zaher, Celia Ribeiro; Varella, Maria Angelica

    This paper provides an overview of the beginnings of the newspaper in Brazil with information on the more significant titles and their role in the history of journalism and their impact on social change that occurred between the Imperial and Republican periods. Current collections at the National Library and legal deposit are discussed. It…

  4. JALT Journal, 2002.

    ERIC Educational Resources Information Center

    Jungheim, Nicholas O., Ed.

    2002-01-01

    These two journal issues include the following articles: "Assistant Foreign Language Teachers in Japanese High Schools: Focus on the Hosting of Japanese Teachers" (Great Gorsuch); "Communicative Language Teaching (Organizational Effectiveness of Upper Secondary School English Language Departments and Their Commitment toward…

  5. Recruiting Blacks into Journalism.

    ERIC Educational Resources Information Center

    Tipton, Leonard; And Others

    Despite significant progress in the recruitment of black journalists, adequate representation of blacks in newsrooms remains an acute concern. The results of (1) statistical monitoring by organizations such as the Newspaper Fund, (2) searching of trade press and academic journal articles for insights into the problem, (3) an open-ended…

  6. JALT Journal, 2001.

    ERIC Educational Resources Information Center

    Fotos, Sandra, Ed.; Jungheim, Nicholas O., Ed.

    2001-01-01

    The two issues in this volume of the "JALT Journal" contain the following articles: "Comprehension and Production Practice in Grammar Instruction: Does Their Combined Use Facilitate Second Language Acquisition?" (Takeo Tanaka); "Professional Development and the JET Program: Insights and Solutions Based on the Sendai City…

  7. Framing Journalism Education

    ERIC Educational Resources Information Center

    Abusharif, Ibrahim N.

    2014-01-01

    Examining the growth, incentives, and progress of overseas campuses of major American educational institutions is an important academic pursuit. To have a complete picture, one must also consider the impact these branch campuses are having on the lives of their students. The Northwestern University in Qatar's journalism program was invited to…

  8. Pedagogy Journal, 2000.

    ERIC Educational Resources Information Center

    Marashio, Nancy, Ed.; Marashio, Paul, Ed.

    2000-01-01

    The theme of the 2000 issue of Pedagogy Journal is finding a "sense of place" within the higher education community. Articles contained discuss this issue as it pertains to different aspects of the postsecondary system. These articles include: (1) "The Role of Left-Brain/Right-Brain Learning Theory in Personal Computer Courses" (Jack Wakelin); (2)…

  9. Launching Family Message Journals.

    ERIC Educational Resources Information Center

    Wollman-Bonilla, Julie

    This lesson introduces Family Message Journals, a tool for encouraging family involvement and supporting writing to reflect and learn. First and second graders are led into composing through demonstration, guided writing, and finally independent writing of messages that they will bring home for family to read and write a reply. During the three…

  10. Writing Journals: An Investigation.

    ERIC Educational Resources Information Center

    Graham, Lynda

    2003-01-01

    Describes a small action research project currently being undertaken by a group of primary teachers and an LEA (Local Education Authority) professional development consultant for English. Explores ways in which the introduction of writing journals enhances children's confidence and competence as writers. Concludes that it seems worth looking…

  11. Library Journal Classics.

    ERIC Educational Resources Information Center

    Berninghausen, David; And Others

    1993-01-01

    Provides excerpts from David Berninghausens's "Social Responsibility vs. the Library Bill of Rights" and responses that appeared in "Library Journal" in 1972 and 1973 because of the continuing debate over the role of the American Library Association (ALA) Social Responsibilities Round Table and whether or not ALA should take…

  12. Social Studies Journal, 2003.

    ERIC Educational Resources Information Center

    West, Leo R., Ed.

    2003-01-01

    This theme issue of the "Social Studies Journal" focuses on the worldwide conflict known in the United States as the French and Indian War (1754-1763). The volume is dedicated to examining the conflict in Pennsylvania. Western Pennsylvania became a battle-scarred landscape as the British and French, with their Native American allies,…

  13. Parent's Journal. [Videotape Series].

    ERIC Educational Resources Information Center

    1999

    Parent's Journal is a set of 16 videotapes for parents of prenatal, infant, and toddler-age children, created by the Alaska Native Home Base Video Project of the Tlingit and Haida Head Start Program. This series offers culturally relevant solutions to the challenges of parenting, drawing on the life stories and experiences of capable mothers and…

  14. CACD Journal, 2001.

    ERIC Educational Resources Information Center

    Wickwire, Pat Nellor, Ed.

    2001-01-01

    This journal of the California Association for Counseling and Development attempts to identify the current issues of concern in the counseling field and share research to help improve the professional learning community. The articles in this issue include: "The Editor's Message" (Pat Nellor Wickwire); "The CACD President's…

  15. Decoupling the scholarly journal

    PubMed Central

    Priem, Jason; Hemminger, Bradley M.

    2011-01-01

    Although many observers have advocated the reform of the scholarly publishing system, improvements to functions like peer review have been adopted sluggishly. We argue that this is due to the tight coupling of the journal system: the system's essential functions of archiving, registration, dissemination, and certification are bundled together and siloed into tens of thousands of individual journals. This tight coupling makes it difficult to change any one aspect of the system, choking out innovation. We suggest that the solution is the “decoupled journal (DcJ).” In this system, the functions are unbundled and performed as services, able to compete for patronage and evolve in response to the market. For instance, a scholar might deposit an article in her institutional repository, have it copyedited and typeset by one company, indexed for search by several others, self-marketed over her own social networks, and peer reviewed by one or more stamping agencies that connect her paper to external reviewers. The DcJ brings publishing out of its current seventeenth-century paradigm, and creates a Web-like environment of loosely joined pieces—a marketplace of tools that, like the Web, evolves quickly in response to new technologies and users' needs. Importantly, this system is able to evolve from the current one, requiring only the continued development of bolt-on services external to the journal, particularly for peer review. PMID:22493574

  16. Existentialism in New Journalism.

    ERIC Educational Resources Information Center

    Dalmia, Shikha

    In 1977, John C. Merrill, a mass communication scholar, found that many scholars believed that the sixties movement of new journalism is in some way related to existentialism. To find this out, a study identified six main themes of the philosophy of existentialism (as espoused by Jean-Paul Sartre) and looked for the presence of these themes in the…

  17. From Conference to Journal

    ERIC Educational Resources Information Center

    McCartney, Robert; Tenenberg, Josh

    2008-01-01

    Revising and extending conference articles for journal publication benefits both authors and readers. The new articles are more complete, and benefit from peer review, feedback from conference presentation, and greater editorial consistency. For those articles that are appropriate, we encourage authors to do this, and present two examples of such…

  18. What are Journals for?

    PubMed Central

    2015-01-01

    ‘The secret is comprised in three words – work, finish, publish.’ Michael Faraday There are many reasons doctors want to publish their work. For most at an early stage in their career, this may be to add a line to their curriculum vitae and advance their careers but for academics, publishing is an expectation. Many will believe they have something important to say, and wish to provoke debate and discussion; others wish to share knowledge and experiences, which in medicine can lead to a satisfying change in clinical practice. All serve to register one’s idea and educate others. However, for some, the reason is as basic as money. As we celebrate the 350th anniversary of the first academic publication, perhaps we have come full circle when it comes to why people publish? Publishing is a flourishing business. There were approximately 28,100 active scholarly peer-reviewed journals in mid-2012, collectively publishing about 1.8–1.9 million articles per year. The number of articles published each year and the number of journals have both grown steadily for more than two centuries, by about 3% and 3.5% per year respectively.1 Journals have a responsibility to refine and define information and act as a scientific filter. Many of us will receive daily invitations in our email inbox from eclectic and new journals that are likely to take anything – is the filter now too porous? But this industry is like any other commercial activity and the supply still far outstrips the demand. Perhaps the internet revolution has merely fuelled our hunger to publish more? The launch of this exciting and innovative series about publishing coincides with the 350th celebration of the publication of the first academic journal. In the age of social media, the first question is ‘What are journals for?’, which Simon Rallison sets out to answer. Simon is Director of Publications at the Physiological Society, and was previously a journal publisher with Earthscan, Springer and Blackwell

  19. What are Journals for?

    PubMed

    Rallison, S P

    2015-03-01

    'The secret is comprised in three words - work, finish, publish.' Michael Faraday There are many reasons doctors want to publish their work. For most at an early stage in their career, this may be to add a line to their curriculum vitae and advance their careers but for academics, publishing is an expectation. Many will believe they have something important to say, and wish to provoke debate and discussion; others wish to share knowledge and experiences, which in medicine can lead to a satisfying change in clinical practice. All serve to register one's idea and educate others. However, for some, the reason is as basic as money. As we celebrate the 350th anniversary of the first academic publication, perhaps we have come full circle when it comes to why people publish? Publishing is a flourishing business. There were approximately 28,100 active scholarly peer-reviewed journals in mid-2012, collectively publishing about 1.8-1.9 million articles per year. The number of articles published each year and the number of journals have both grown steadily for more than two centuries, by about 3% and 3.5% per year respectively. (1) Journals have a responsibility to refine and define information and act as a scientific filter. Many of us will receive daily invitations in our email inbox from eclectic and new journals that are likely to take anything - is the filter now too porous? But this industry is like any other commercial activity and the supply still far outstrips the demand. Perhaps the internet revolution has merely fuelled our hunger to publish more? The launch of this exciting and innovative series about publishing coincides with the 350th celebration of the publication of the first academic journal. In the age of social media, the first question is 'What are journals for?', which Simon Rallison sets out to answer. Simon is Director of Publications at the Physiological Society, and was previously a journal publisher with Earthscan, Springer and Blackwell. Writing is

  20. 77 FR 32394 - Safety Zones: Catawba Island Club Fire Works, Catawba Island Club, Port Clinton, OH; Racing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ... Island Club, Port Clinton, OH; Racing for Recovery, Lake Erie, Sterling State Park, Monroe, MI; Put-in-Bay Fireworks, Fox's the Dock Pier, South Bass Island, Put-in-Bay, OH AGENCY: Coast Guard, DHS. ACTION... ] Sterling State Park, Monroe, MI; and on Lake Erie in the vicinity of South Bass Island, Put-in-Bay,...

  1. Biochemical and Structural Characterization of Germicidin Synthase: Analysis of a Type III Polyketide Synthase That Employs Acyl-ACP as a Starter Unit Donor

    SciTech Connect

    Chemler, Joseph A.; Buchholz, Tonia J.; Geders, Todd W.; Akey, David L.; Rath, Christopher M.; Chlipala, George E.; Smith, Janet L.; Sherman, David H.

    2012-08-10

    Germicidin synthase (Gcs) from Streptomyces coelicolor is a type III polyketide synthase (PKS) with broad substrate flexibility for acyl groups linked through a thioester bond to either coenzyme A (CoA) or acyl carrier protein (ACP). Germicidin synthesis was reconstituted in vitro by coupling Gcs with fatty acid biosynthesis. Since Gcs has broad substrate flexibility, we directly compared the kinetic properties of Gcs with both acyl-ACP and acyl-CoA. The catalytic efficiency of Gcs for acyl-ACP was 10-fold higher than for acyl-CoA, suggesting a strong preference toward carrier protein starter unit transfer. The 2.9 {angstrom} germicidin synthase crystal structure revealed canonical type III PKS architecture along with an unusual helical bundle of unknown function that appears to extend the dimerization interface. A pair of arginine residues adjacent to the active site affect catalytic activity but not ACP binding. This investigation provides new and surprising information about the interactions between type III PKSs and ACPs that will facilitate the construction of engineered systems for production of novel polyketides.

  2. Positioning Open Access Journals in a LIS Journal Ranking

    ERIC Educational Resources Information Center

    Xia, Jingfeng

    2012-01-01

    This research uses the h-index to rank the quality of library and information science journals between 2004 and 2008. Selected open access (OA) journals are included in the ranking to assess current OA development in support of scholarly communication. It is found that OA journals have gained momentum supporting high-quality research and…

  3. Three journal similarity metrics and their application to biomedical journals.

    PubMed

    D'Souza, Jennifer L; Smalheiser, Neil R

    2014-01-01

    In the present paper, we have created several novel journal similarity metrics. The MeSH odds ratio measures the topical similarity of any pair of journals, based on the major MeSH headings assigned to articles in MEDLINE. The second metric employed the 2009 Author-ity author name disambiguation dataset as a gold standard for estimating the author odds ratio. This gives a straightforward, intuitive answer to the question: Given two articles in PubMed that share the same author name (lastname, first initial), how does knowing only the identity of the journals (in which the articles were published) predict the relative likelihood that they are written by the same person vs. different persons? The article pair odds ratio detects the tendency of authors to publish repeatedly in the same journal, as well as in specific pairs of journals. The metrics can be applied not only to estimate the similarity of a pair of journals, but to provide novel profiles of individual journals as well. For example, for each journal, one can define the MeSH cloud as the number of other journals that are topically more similar to it than expected by chance, and the author cloud as the number of other journals that share more authors than expected by chance. These metrics for journal pairs and individual journals have been provided in the form of public datasets that can be readily studied and utilized by others.

  4. The Writer's Journal: 40 Contemporary Writers and Their Journals.

    ERIC Educational Resources Information Center

    Bender, Sheila, Ed.

    This anthology presents excerpts from the journals of 40 of today's most noted writers, along with their comments on the role of journal-keeping in creating their art. Besides being generally instructional to other writers and a lesson in how to create a personal journal, the anthology is a look at writers in the midst of creating. It includes…

  5. Metabolic engineering of fatty acyl-ACP reductase-dependent pathway to improve fatty alcohol production in Escherichia coli.

    PubMed

    Liu, Ran; Zhu, Fayin; Lu, Lei; Fu, Aisi; Lu, Jiankai; Deng, Zixin; Liu, Tiangang

    2014-03-01

    Fatty alcohols are important components of surfactants and cosmetic products. The production of fatty alcohols from sustainable resources using microbial fermentation could reduce dependence on fossil fuels and greenhouse gas emission. However, the industrialization of this process has been hampered by the current low yield and productivity of this synthetic pathway. As a result of metabolic engineering strategies, an Escherichia coli mutant containing Synechococcus elongatus fatty acyl-ACP reductase showed improved yield and productivity. Proteomics analysis and in vitro enzymatic assays showed that endogenous E. coli AdhP is a major contributor to the reduction of fatty aldehydes to fatty alcohols. Both in vitro and in vivo results clearly demonstrated that the activity and expression level of fatty acyl-CoA/ACP reductase is the rate-limiting step in the current protocol. In 2.5-L fed-batch fermentation with glycerol as the only carbon source, the most productive E. coli mutant produced 0.75 g/L fatty alcohols (0.02 g fatty alcohol/g glycerol) with a productivity of up to 0.06 g/L/h. This investigation establishes a promising synthetic pathway for industrial microbial production of fatty alcohols.

  6. SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function.

    PubMed

    Li, Man; Li, Yong; Weeks, Olivia; Mijatovic, Vladan; Teumer, Alexander; Huffman, Jennifer E; Tromp, Gerard; Fuchsberger, Christian; Gorski, Mathias; Lyytikäinen, Leo-Pekka; Nutile, Teresa; Sedaghat, Sanaz; Sorice, Rossella; Tin, Adrienne; Yang, Qiong; Ahluwalia, Tarunveer S; Arking, Dan E; Bihlmeyer, Nathan A; Böger, Carsten A; Carroll, Robert J; Chasman, Daniel I; Cornelis, Marilyn C; Dehghan, Abbas; Faul, Jessica D; Feitosa, Mary F; Gambaro, Giovanni; Gasparini, Paolo; Giulianini, Franco; Heid, Iris; Huang, Jinyan; Imboden, Medea; Jackson, Anne U; Jeff, Janina; Jhun, Min A; Katz, Ronit; Kifley, Annette; Kilpeläinen, Tuomas O; Kumar, Ashish; Laakso, Markku; Li-Gao, Ruifang; Lohman, Kurt; Lu, Yingchang; Mägi, Reedik; Malerba, Giovanni; Mihailov, Evelin; Mohlke, Karen L; Mook-Kanamori, Dennis O; Robino, Antonietta; Ruderfer, Douglas; Salvi, Erika; Schick, Ursula M; Schulz, Christina-Alexandra; Smith, Albert V; Smith, Jennifer A; Traglia, Michela; Yerges-Armstrong, Laura M; Zhao, Wei; Goodarzi, Mark O; Kraja, Aldi T; Liu, Chunyu; Wessel, Jennifer; Boerwinkle, Eric; Borecki, Ingrid B; Bork-Jensen, Jette; Bottinger, Erwin P; Braga, Daniele; Brandslund, Ivan; Brody, Jennifer A; Campbell, Archie; Carey, David J; Christensen, Cramer; Coresh, Josef; Crook, Errol; Curhan, Gary C; Cusi, Daniele; de Boer, Ian H; de Vries, Aiko P J; Denny, Joshua C; Devuyst, Olivier; Dreisbach, Albert W; Endlich, Karlhans; Esko, Tõnu; Franco, Oscar H; Fulop, Tibor; Gerhard, Glenn S; Glümer, Charlotte; Gottesman, Omri; Grarup, Niels; Gudnason, Vilmundur; Hansen, Torben; Harris, Tamara B; Hayward, Caroline; Hocking, Lynne; Hofman, Albert; Hu, Frank B; Husemoen, Lise Lotte N; Jackson, Rebecca D; Jørgensen, Torben; Jørgensen, Marit E; Kähönen, Mika; Kardia, Sharon L R; König, Wolfgang; Kooperberg, Charles; Kriebel, Jennifer; Launer, Lenore J; Lauritzen, Torsten; Lehtimäki, Terho; Levy, Daniel; Linksted, Pamela; Linneberg, Allan; Liu, Yongmei; Loos, Ruth J F; Lupo, Antonio; Meisinger, Christine; Melander, Olle; Metspalu, Andres; Mitchell, Paul; Nauck, Matthias; Nürnberg, Peter; Orho-Melander, Marju; Parsa, Afshin; Pedersen, Oluf; Peters, Annette; Peters, Ulrike; Polasek, Ozren; Porteous, David; Probst-Hensch, Nicole M; Psaty, Bruce M; Qi, Lu; Raitakari, Olli T; Reiner, Alex P; Rettig, Rainer; Ridker, Paul M; Rivadeneira, Fernando; Rossouw, Jacques E; Schmidt, Frank; Siscovick, David; Soranzo, Nicole; Strauch, Konstantin; Toniolo, Daniela; Turner, Stephen T; Uitterlinden, André G; Ulivi, Sheila; Velayutham, Dinesh; Völker, Uwe; Völzke, Henry; Waldenberger, Melanie; Wang, Jie Jin; Weir, David R; Witte, Daniel; Kuivaniemi, Helena; Fox, Caroline S; Franceschini, Nora; Goessling, Wolfram; Köttgen, Anna; Chu, Audrey Y

    2017-03-01

    Genome-wide association studies have identified >50 common variants associated with kidney function, but these variants do not fully explain the variation in eGFR. We performed a two-stage meta-analysis of associations between genotypes from the Illumina exome array and eGFR on the basis of serum creatinine (eGFRcrea) among participants of European ancestry from the CKDGen Consortium (nStage1: 111,666; nStage2: 48,343). In single-variant analyses, we identified single nucleotide polymorphisms at seven new loci associated with eGFRcrea (PPM1J, EDEM3, ACP1, SPEG, EYA4, CYP1A1, and ATXN2L; PStage1<3.7×10(-7)), of which most were common and annotated as nonsynonymous variants. Gene-based analysis identified associations of functional rare variants in three genes with eGFRcrea, including a novel association with the SOS Ras/Rho guanine nucleotide exchange factor 2 gene, SOS2 (P=5.4×10(-8) by sequence kernel association test). Experimental follow-up in zebrafish embryos revealed changes in glomerular gene expression and renal tubule morphology in the embryonic kidney of acp1- and sos2-knockdowns. These developmental abnormalities associated with altered blood clearance rate and heightened prevalence of edema. This study expands the number of loci associated with kidney function and identifies novel genes with potential roles in kidney formation.

  7. Making sense of journal publishing

    NASA Astrophysics Data System (ADS)

    Campbell, Robert

    1982-10-01

    With cut-backs in library budgets it is hard to understand why new journals continue to appear. Here Robert Campbell discusses the economics of journal publishing and the prognosis for this part of the scientific literature.

  8. Publishing corruption discussion: predatory journalism.

    PubMed

    Jones, James W; McCullough, Laurence B

    2014-02-01

    Dr Spock is a brilliant young vascular surgeon who is up for tenure next year. He has been warned by the chair of surgery that he needs to increase his list of publications to assure passage. He has recently had a paper reviewed by one of the top journals in his specialty, Journal X-special, with several suggestions for revision. He received an e-mail request for manuscript submission from a newly minted, open access, Journal of Vascular Disease Therapy, which promises a quick and likely favorable response for a fee. What should be done? A. Send the paper to another peer reviewed journal with the suggested revisions. B. Resubmit the paper to Journal X-special. C. Submit to the online journal as is to save time. D. Submit to the online journal and another regular journal. E. Look for another job.

  9. Our World: Journaling in Space

    NASA Video Gallery

    Learn how famous explorers, scientists and even NASA use journals and science notebooks to record observations about Our World. See why journaling is important on the International Space Station to...

  10. Exploring strategies to improve the health promotion orientation of Flemish sports clubs.

    PubMed

    Meganck, Jeroen; Seghers, Jan; Scheerder, Jeroen

    2016-02-29

    Sports clubs are increasingly recognized as an innovative setting for health promotion, as exemplified by the health promoting sports club concept. This study aims to assess the health promotion orientation of both youth sports clubs (YSC) and adult sports clubs (ASC) in Flanders and to identify the motives and barriers as reported by their representatives as a basis for proposing intervention strategies to improve the health promotion orientation in sports clubs. A total of 253 Flemish sports clubs, consisting of 156 YSC and of 97 ASC, completed the online questionnaire, covering club characteristics (e.g. finances, human resources), perceived motives and barriers for health promotion and the health promoting sports club index. Even though YSC were more health promoting than ASC, the results indicated that all sports clubs could improve their health promotion orientation. The most consistent predictors of health promotion orientation are perceived motives index for YSC and perceived lack of resources for ASC. Based on these results, interventions to enhance the health promoting orientation need to tackle the lack of resources such as lack of expertise regarding health promotion. Interventions aimed specifically at YSC should emphasize the direct benefits, for example by demonstrating how health promotion helps clubs to improve the provision of high quality sports participation and by awarding a health promotion quality label.

  11. Practical Ideas for Teaching Journalism.

    ERIC Educational Resources Information Center

    Bustrum, Dwight, Ed.; Hallenbeck, Carol, Ed.; Rittger, Alison, Ed.

    A "how-to" book for advisers looking for creative and contemporary ways to teach journalism, this book can be a single source for a journalism class or a supplement to any high school journalism text. The book concentrates on teaching methods as well as subject matter--it tells teachers what to do and how to do it, what to say and what…

  12. Journalism in a Free Society.

    ERIC Educational Resources Information Center

    Edwards, Verne E., Jr.

    Broadcast and print journalism are interrelated in this book's coverage of the functions and status of the "fourth estate". A first part discusses journalism's magnitude and significance, with separate chapters offering a profile of the press, a discussion of the people's need to know, and a brief history of American journalism. The second part…

  13. Scholastic Journalism Education: Benchmark 1982.

    ERIC Educational Resources Information Center

    Shenton, Stephen G-M.; Smith, Anne

    Noting that no institution listed in "Accredited Journalism and Mass Communications Education, 1981-82" offers a scholastic journalism or secondary education sequence accredited by the American Council on Education in Journalism and Mass Communications, a study was conducted to examine the courses in the sequences that were offered at the…

  14. Evaluation of OAS Education Journals.

    ERIC Educational Resources Information Center

    Leavitt, Howard B.; And Others

    An in-depth evaluation of four Organization of American States educational journals is presented. The journals, published for distribution among Latin American countries, were "Tecnologia Educativa", "Curriculum", "Educacion de Adultors", and "La Educacion". Assessment was made of the journals' mandates, implementation procedures, and managerial…

  15. Journalism and Writing: A Roundtable.

    ERIC Educational Resources Information Center

    ABCA Bulletin, 1983

    1983-01-01

    Authors discuss (1) journalism and business writing as ways of learning to write, (2) differences between journalism and business writing, (3) a journalistic approach to solving business communication problems, and (4) business communication and journalism sharing a common goal of effective communication. (HTH)

  16. Hydrogeology Journal in 2002

    USGS Publications Warehouse

    Olcott, Perry; Schneider, Robert; Voss, Clifford

    2003-01-01

    Hydrogeology Journal appeared in six issues containing a total of 674 pages and 47 major articles, including 22 Papers and 24 Reports, as well as Technical Notes and Book Reviews. The final issue of 2002 also contained the annual volume index. Hydrogeology Journal (HJ) is an international forum for hydrogeology and related disciplines. Authors in 2002 were from about 30 countries. Articles advanced hydrogeologic science and described hydrogeologic systems in many regions worldwide. These articles focused on 22 countries: Afghanistan, Argentina, Australia, Austria, Belgium, Brazil, Canada, China, India, Israel, Japan, Jordan, Mexico, New Zealand, Nigeria, Portugal, Qatar, Switzerland, Syria, Turkey, UK, and the USA. The Guest Editors of the 2002 HJ theme issue on "Groundwater Recharge", Bridget R. Scanlon and Peter G. Cook, assembled a highly relevant and sought-after collection of papers from eminent authors on wide-ranging aspects of the subject.

  17. Bibliography of Journal Holdings

    DTIC Science & Technology

    1988-06-01

    Abstract iournal of metallurgy (1958)-(1963) Part B. Technology of metals Academie Polonaise des Sciences. V.18 (1970)- Bulletin (Maths, astronom et ...V.18 (1966) Aeronautique et lastronautique (1969)-(1986) Aeroplane. Incorporated in Flight V.71 (1946)- imperfect international from December 1968...ATandT Bell laboratories tachi , al journal Bibliography on industrial diamond V.6 (1949)- imperfect applications. Title changed to V.14 (1957

  18. Essay: early American genetics journals.

    PubMed

    Crow, James F

    2005-09-01

    Before the Second World War, there were only two North-American journals exclusively devoted to genetics - the Journal of Heredity and Genetics. In the late 1940s, Genetics spawned two progeny - the American Journal of Human Genetics and Evolution. This article recounts the early days of these journals, their influential and often colourful founding editors, and their contents. It emphasizes the contrast between those years, when a reader had a realistic chance of keeping up with the whole field, and the current plethora of journals that makes it impossible to keep up with even the tables of contents.

  19. Journal bias or author bias?

    PubMed

    Harris, Ian

    2016-01-01

    I read with interest the comment by Mark Wilson in the Indian Journal of Medical Ethics regarding bias and conflicts of interest in medical journals. Wilson targets one journal (the New England Journal of Medicine: NEJM) and one particular "scandal" to make his point that journals' decisions on publication are biased by commercial conflicts of interest (CoIs). It is interesting that he chooses the NEJM which, by his own admission, had one of the strictest CoI policies and had published widely on this topic. The feeling is that if the NEJM can be guilty, they can all be guilty.

  20. Elsevier challenged over journal operations

    NASA Astrophysics Data System (ADS)

    Banks, Michael

    2009-01-01

    Researchers are questioning the method used to monitor the quality of a scientific journal belonging to the Dutch publishing giant Elsevier after its editor-in-chief was found to be publishing almost all his papers in the journal. Mohamed El Naschie, editor-in-chief of Chaos, Solitons and Fractals (CSF), published 58 papers last year, of which 53 are in the journal itself. Elsevier will announce his retirement from CSF, which had been planned since mid-2007, in the first issue of the journal this year. The company also plans to revamp the journal's submission process.

  1. Journal Self-Citedness in "Journal Citation Reports" Library and Information Science and Genetics Journal Rankings.

    ERIC Educational Resources Information Center

    Nisonger, Thomas E.

    1998-01-01

    Investigates the effect of journal self-citedness on "Journal Citation Reports" (JCR) rankings of library and information science and genetics journals using data from 1994 on CD-ROM. Results for library and information science indicate that the effect of self-citedness on both JCR impact factor and total citation rankings was minimal.…

  2. The Supernova Club: Bringing Space Science to Urban Youths

    NASA Astrophysics Data System (ADS)

    Sakimoto, P. J.; Pettit, R.; Balsara, D.; Garnavich, P.

    2008-06-01

    The Supernova Club is an experiment aimed at bringing space science to youths, almost all African Americans, from the most severely disadvantaged areas of the South Bend, Indiana, region. It leverages the National Youth Sports Program (NYSP) that, in Summer 2007, brought 100 children, ages 10-16 and living at or below the poverty level, to the Notre Dame campus for a 4-week non-residential summer program. Six contact hours of space science instruction were added to the core curriculum of nutrition, physical fitness, and academic study. At summer's end, 13 high interest/high potential youths were selected to form ``The Supernova Club''-a year-round, after-school, weekly follow-up program.

  3. Drink-driving in community sports clubs: adopting the Good Sports alcohol management program.

    PubMed

    Rowland, Bosco; Toumbourou, John; Allen, Felicity

    2012-09-01

    Throughout the developed world, community sports clubs are a high-risk setting for alcohol-impaired driving. The Good Sports program accredits community sports clubs to encourage implementation of alcohol-focussed harm-reduction and safe-transport strategies. This study tested for associations between participation in the Good Sports program and reduced rates of drink-driving amongst club members. Multilevel modelling indicated that for each season a club was in the program there was an 8% reduction in the odds of drink-driving. These findings may arise due to clubs with lower rates of alcohol use maintaining longer involvement in the program. However, the findings are also compatible with the intention of the Good Sports program to reduce the risk that club members will drive whilst alcohol impaired.

  4. Club-Cutting” Dystonic Tremor: a Case Report

    PubMed Central

    Roberts, Kinley; Mahon, Barry; O’Rourke, Killian; Lynch, Timothy

    2013-01-01

    Background Focal task-specific dystonic postures are well recognized. Often a tremor may be the main feature with little or no dystonia. These have been well reported in writers, musicians, and sportspeople. Case Report Herein we report a novel task-specific dystonic tremor in a 44-year-old Irish hairdresser due to club-cutting, a standard haircutting technique. Discussion Hairdresser’s dystonia is a novel task-specific dystonia. PMID:24156085

  5. A little nightclub medicine: the healthcare implications of clubbing

    PubMed Central

    Luke, L; Dewar, C; Bailey, M; McGreevy, D; Morris, H; Burdett-Smith, P

    2002-01-01

    Objective: To describe the scale and range of acute medical problems among patients who present to an inner city accident and emergency (A&E) department after attending nightclubs in Liverpool. Methods: From April 1997 to April 1998, all patients identified as having attended a nightclub before their arrival at the department were included in the study. Information regarding their attendance was gathered retrospectively using a standard proforma. Setting: A large, city centre, teaching hospital A&E department with an annual new patient attendance rate of over 95 000. Result: 777 such patients were enrolled in the study (0.81% of all new attendances during the same period). This was probably an underestimate, as some eligible patients were not identified during the study. Predictably, most presentations were at the weekend between midnight and 08.00. Suprisingly, the commonest mode of transport to the hospital was an ambulance (38%, 298 of the total). Assault accounted for most presentations (57%, 443 of the total) and lacerations were the commonest injury (the face being most frequently affected). Alcohol was the commonest intoxicant overtly associated with the A&E department attendance. Conclusions: Injury after assault is the commonest precipitant of hospital care among clubbers in Liverpool. Alcohol is the most important contributory factor, although illegal drug misuse is a considerable challenge in the clubs themselves. A number of measures such as (a) the introduction of unbreakable glass or plastic containers; (b) the elimination of glass from outside clubs; (c) the provision of high quality immediate medical care at larger venues; (d) the curbing of over crowding and cheap drinks promotions; (e) registration of doormen, and (f) targeted policing of the areas around nightclubs are urgently required to reduce the healthcare (and civic) burden of clubbing. The cost for these should be borne by the highly profitable clubbing and brewing industries. A national

  6. SciTech Clubs for Girls. [Annual] technical report

    SciTech Connect

    Nogal, A.M.

    1993-02-01

    Since January 1992, 9 exhibits have been constructed by the SciTech Clubs for Girls, which involved 63 girls, ages 10 to 14. These exhibits are: Bubble Shapes by the St. Charles Cadette Girl Scout Troop No. 109. Density Games by the South Elgin Cadette Girl Scout Troop No. 132. Electric Fleas by the Warrenville Junior Girl Scout Troop No. 305. Energy vs. Power by the Aurora Junior Girl Scout Troop No. 242. The Organ Pipe by the Bartlett Junior Girl Scout Troop No. 107. Ohm`s Law by the Geneva Junior Girl Scout Troop No. 401. What is Gravity by the Pilsen YMCA girls. Insulation at Work by the Algonquin Junior Girl Scout Troop No. 303. Series vs. Parallel by the Leland Junior Girl Scout Troop No. 50. The report is a description of each exhibit and the group that built the exhibit. Each group had a minimum of 10 hours of contact time at SciTech with the SciTech Clubs for Girls Program Coordinator. All mentors are female. Each exhibit building experience includes a trip to the hardware store to purchase supplies. After the exhibit is complete, the girls receive certificates of achievement and a SciTech Club Patch.

  7. 21 CFR 133.123 - Cold-pack and club cheese.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Cold-pack and club cheese. 133.123 Section 133.123... Cheese and Related Products § 133.123 Cold-pack and club cheese. (a)(1) Cold-pack cheese, club cheese, is... before being comminuted. (3)(i) The moisture content of a cold-pack cheese made from a single variety...

  8. 21 CFR 133.123 - Cold-pack and club cheese.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Cold-pack and club cheese. 133.123 Section 133.123... Cheese and Related Products § 133.123 Cold-pack and club cheese. (a)(1) Cold-pack cheese, club cheese, is... before being comminuted. (3)(i) The moisture content of a cold-pack cheese made from a single variety...

  9. 21 CFR 133.123 - Cold-pack and club cheese.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Cold-pack and club cheese. 133.123 Section 133.123... Cheese and Related Products § 133.123 Cold-pack and club cheese. (a)(1) Cold-pack cheese, club cheese, is... before being comminuted. (3)(i) The moisture content of a cold-pack cheese made from a single variety...

  10. ISI's Journal Citation Reports on the Web.

    PubMed

    Fitzpatrick, Roberta Bronson

    2003-01-01

    This column features an overview of the Institute for Scientific Information's (ISI) Journal Citation Reports (JCR) database. Basic searching techniques are presented, as well as simple ways to manipulate data contained in the file. The Journal Citation Reports database can provide information on highest impact journals, most frequently used journals, "hottest" journals, and largest journals in a field or discipline.

  11. Algorithmic Procedure for Finding Semantically Related Journals.

    ERIC Educational Resources Information Center

    Pudovkin, Alexander I.; Garfield, Eugene

    2002-01-01

    Using citations, papers and references as parameters a relatedness factor (RF) is computed for a series of journals. Sorting these journals by the RF produces a list of journals most closely related to a specified starting journal. The method appears to select a set of journals that are semantically most similar to the target journal. The…

  12. Statistical significance of the rich-club phenomenon in complex networks

    NASA Astrophysics Data System (ADS)

    Jiang, Zhi-Qiang; Zhou, Wei-Xing

    2008-04-01

    We propose that the rich-club phenomenon in complex networks should be defined in the spirit of bootstrapping, in which a null model is adopted to assess the statistical significance of the rich-club detected. Our method can serve as a definition of the rich-club phenomenon and is applied to analyze three real networks and three model networks. The results show significant improvement compared with previously reported results. We report a dilemma with an exceptional example, showing that there does not exist an omnipotent definition for the rich-club phenomenon.

  13. The youth sports club as a health-promoting setting: An integrative review of research

    PubMed Central

    Quennerstedt, Mikael; Eriksson, Charli

    2013-01-01

    Aims: The aims of this review is to compile and identify key issues in international research about youth sports clubs as health-promoting settings, and then discuss the results of the review in terms of a framework for the youth sports club as a health-promoting setting. Methods: The framework guiding this review of research is the health-promoting settings approach introduced by the World Health Organization (WHO). The method used is the integrated review. Inclusion criteria were, first, that the studies concerned sports clubs for young people, not professional clubs; second, that it be a question of voluntary participation in some sort of ongoing organized athletics outside of the regular school curricula; third, that the studies consider issues about youth sports clubs in terms of health-promoting settings as described by WHO. The final sample for the review consists of 44 publications. Results: The review shows that youth sports clubs have plentiful opportunities to be or become health-promoting settings; however this is not something that happens automatically. To do so, the club needs to include an emphasis on certain important elements in its strategies and daily practices. The youth sports club needs to be a supportive and healthy environment with activities designed for and adapted to the specific age-group or stage of development of the youth. Conclusions: To become a health-promoting setting, a youth sports club needs to take a comprehensive approach to its activities, aims, and purposes. PMID:23349167

  14. New NAS journal

    NASA Astrophysics Data System (ADS)

    In April 1984 the National Academy of Sciences (NAS) will begin publishing a new quarterly focusing on science policy. Written primarily for legislators, diplomats, corporate managers, security analysts, and other public policy analysts, the new journal will deal with such diverse topics as arms control, economic competition, social change, and health care.Original articles are expected to create a 120-page periodical that will discuss policy issues on a sophisticated but nonspecialist level, in a manner similar to that which Foreign Affairs uses to discuss U.S. foreign policy topics, according to NAS.

  15. Cloning of Acyl-ACP Thioesterase FatA from Arachis hypogaea L. and Its Expression in Escherichia coli

    PubMed Central

    Chen, Gao; Peng, Zhen-ying; Shan, Lei; Xuan, Ning; Tang, Gui-ying; Zhang, Yan; Li, Lan; He, Qing-fang; Bi, Yu-ping

    2012-01-01

    In this study, a full-length cDNA of the acyl-ACP thioesterase, AhFatA, was cloned from developing seeds of Arachis hypogaea L. by 3′-RACE. Sequence analysis showed that the open reading frame encodes a peptide of 372 amino acids and has 50–70% identity with FatA from other plants. Real-time quantitative PCR analysis revealed that AhFatA was expressed in all tissues of A. hypogaea L., but most strongly in the immature seeds harvested at 60 days after pegging. Heterologous expression of AhFatA in Escherichia coli affected bacterial growth and changed the fatty acid profiles of the membrane lipid, resulting in directed accumulation towards palmitoleic acid and oleic acid. These results indicate that AhFatA is at least partially responsible for determining the high palmitoleic acid and oleic acid composition of E. coli. PMID:23093853

  16. Campylobacter jejuni fatty acid synthase II: Structural and functional analysis of [beta]-hydroxyacyl-ACP dehydratase (FabZ)

    SciTech Connect

    Kirkpatrick, Andrew S.; Yokoyama, Takeshi; Choi, Kyoung-Jae; Yeo, Hye-Jeong

    2009-08-14

    Fatty acid biosynthesis is crucial for all living cells. In contrast to higher organisms, bacteria use a type II fatty acid synthase (FAS II) composed of a series of individual proteins, making FAS II enzymes excellent targets for antibiotics discovery. The {beta}-hydroxyacyl-ACP dehydratase (FabZ) catalyzes an essential step in the FAS II pathway. Here, we report the structure of Campylobacter jejuni FabZ (CjFabZ), showing a hexamer both in crystals and solution, with each protomer adopting the characteristic hot dog fold. Together with biochemical analysis of CjFabZ, we define the first functional FAS II enzyme from this pathogen, and provide a framework for investigation on roles of FAS II in C. jejuni virulence

  17. Evolution of the AKH/corazonin/ACP/GnRH receptor superfamily and their ligands in the Protostomia.

    PubMed

    Hauser, Frank; Grimmelikhuijzen, Cornelis J P

    2014-12-01

    In this review we trace the evolutionary connections between GnRH receptors from vertebrates and the receptors for adipokinetic hormone (AKH), AKH/corazonin-related peptide (ACP), and corazonin from arthropods. We conclude that these G protein-coupled receptors (GPCRs) are closely related and have a common evolutionary origin, which dates back to the split of Proto- and Deuterostomia, about 700 million years ago. We propose that in the protostomian lineage, the ancestral GnRH-like receptor gene duplicated as did its GnRH-like ligand gene, followed by diversification, leading to (i) a corazonin receptor gene and a corazonin-like ligand gene, and (ii) an AKH receptor gene and an AKH-like ligand gene in the Mollusca and Annelida. Subsequently, the AKH receptor and ligand genes duplicated once more, yielding the situation that we know from arthropods today, where three independent hormonal systems exist, signalling with AKH, ACP, and corazonin. Our model for the evolution of GnRH signaling in the Protostomia is a striking example of receptor-ligand co-evolution. This model has been developed using several bioinformatics tools (TBLASTN searches, phylogenetic tree analyses), which also helped us to annotate six novel AKH preprohormones and their corresponding AKH sequences from the following molluscs: the sea hare Aplysia californica (AKH sequence: pQIHFSPDWGTamide), the sea slug Tritonia diomedea (pQIHFSPGWEPamide), the fresh water snail Bithynia siamensis goniomphalos (pQIHFTPGWGSamide), the owl limpet Lottia gigantea (pQIHFSPTWGSamide), the oyster Crassostrea gigas (pQVSFSTNWGSamide), and the freshwater pearl mussel Hyriopsis cumingii (pQISFSTNWGSamide). We also found AKHs in the tardigrade Hysibius dujardini (pQLSFTGWGHamide), the rotifer Brachionus calycifloros (pQLTFSSDWSGamide), and the penis worm Priapulus caudatus (pQIFFSKGWRGamide). This is the first report, showing that AKH signaling is widespread in molluscs.

  18. Crystallization and preliminary X-ray crystallographic analysis of enoyl-ACP reductase III (FabL) from Bacillus subtilis

    SciTech Connect

    Kim, Kook-Han; Park, Joon Kyu; Ha, Byung Hak; Moon, Jin Ho; Kim, Eunice EunKyeong

    2007-03-01

    Enoyl-ACP reductase III (FabL) from B. subtilis has been overexpressed, purified and crystallized. The crystal belongs to space group P622, with unit-cell parameters a = b = 139.56, c = 62.75 Å, α = β = 90, γ = 120°, and data were collected to 2.5 Å resolution using synchrotron radiation. Enoyl-[acyl-carrier protein] reductase (enoyl-ACP reductase; ENR) is a key enzyme in type II fatty-acid synthase that catalyzes the last step in each elongation cycle. It has been considered as an antibiotic target since it is an essential enzyme in bacteria. However, recent studies indicate that some pathogens have more than one ENR. Bacillus subtilis is reported to have two ENRs, namely BsFabI and BsFabL. While BsFabI is similar to other FabIs, BsFabL shows very little sequence similarity and is NADPH-dependent instead of NADH-dependent as in the case of FabI. In order to understand these differences on a structural basis, BsFabL has been cloned, expressed and and crystallized. The crystal belongs to space group P622, with unit-cell parameters a = b = 139.56, c = 62.75 Å, α = β = 90, γ = 120° and one molecule of FabL in the asymmetric unit. Data were collected using synchrotron radiation (beamline 4A at the Pohang Light Source, Korea). The crystal diffracted to 2.5 Å resolution.

  19. X-ray structure of putative acyl-ACP desaturase DesA2 from Mycobacterium tuberculosis H37Rv

    SciTech Connect

    Dyer, David H.; Lyle, Karen S.; Rayment, Ivan; Fox, Brian G.

    2010-07-13

    Genome sequencing showed that two proteins in Mycobacterium tuberculosis H37Rv contain the metal binding motif (D/E)X{sub 2}HX{sub {approx}100}(D/E)X{sub 2}H characteristic of the soluble diiron enzyme superfamily. These putative acyl-ACP desaturase genes desA1 and desA2 were cloned from genomic DNA and expressed in Escherichia coli BL21(DE3). DesA1 was found to be insoluble, but in contrast, DesA2 was a soluble protein amenable to biophysical characterization. Here, we report the 2.0 {angstrom} resolution X-ray structure of DesA2 determined by multiple anomalous dispersion (MAD) phasing from a Se-met derivative and refinement against diffraction data obtained on the native protein. The X-ray structure shows that DesA2 is a homodimeric protein with a four-helix bundle core flanked by five additional helices that overlay with 192 structurally equivalent amino acids in the structure of stearoyl-ACP {Delta}9 desaturase from castor plant with an rms difference 1.42 {angstrom}. In the DesA2 crystals, one metal (likely Mn from the crystallization buffer) was bound in high occupancy at the B-site of the conserved metal binding motif, while the A-site was not occupied by a metal ion. Instead, the amino group of Lys-76 occupied this position. The relationships between DesA2 and known diiron enzymes are discussed.

  20. Expanding Access and Increasing Success in Postsecondary Education for Arizonans. The Arizona Commission for Postsecondary Education (ACPE) 2009-2010 Annual Report

    ERIC Educational Resources Information Center

    Arizona Commission for Postsecondary Education, 2010

    2010-01-01

    The work of the Arizona Commission for Postsecondary Education (ACPE) is guided by a strategic plan. The purpose of the plan is to provide focus for the activity of this small agency and its five staff members in order to increase productivity and impact in the areas of its statutory authority. The mission and goals were accepted by Commissioners…

  1. Expanding Access and Increasing Success in Postsecondary Education for Arizonans. The Arizona Commission for Postsecondary Education (ACPE) 2006-2007 Annual Report

    ERIC Educational Resources Information Center

    Arizona Commission for Postsecondary Education, 2007

    2007-01-01

    The work of the Arizona Commission for Postsecondary Education (ACPE) is guided by a 5 year strategic plan. The purpose of the plan is to provide focus for the activity of this small agency and its eight staff members in order to increase productivity and impact in the areas of its statutory authority. The mission and goals were accepted by…

  2. Expanding Access and Increasing Success in Postsecondary Education for Arizonans. The Arizona Commission for Postsecondary Education (ACPE) 2007-2008 Annual Report

    ERIC Educational Resources Information Center

    Arizona Commission for Postsecondary Education, 2008

    2008-01-01

    The work of the Arizona Commission for Postsecondary Education (ACPE) is guided by a 5-year strategic plan. The purpose of the plan is to provide focus for the activity of this small agency and its nine staff members in order to increase productivity and impact in the areas of its statutory authority. The mission and goals were accepted by …

  3. Expanding Access and Increasing Success in Postsecondary Education for Arizonans. The Arizona Commission for Postsecondary Education (ACPE) 2008-2009 Annual Report

    ERIC Educational Resources Information Center

    Arizona Commission for Postsecondary Education, 2009

    2009-01-01

    The work of the Arizona Commission for Postsecondary Education (ACPE) is guided by a 5-year strategic plan. The purpose of the plan is to provide focus for the activity of this small agency and its eight staff members in order to increase productivity and impact in the areas of its statutory authority. The mission and goals were accepted by…

  4. Forward Genetic Screen in Caenorhabditis elegans Suggests F57A10.2 and acp-4 As Suppressors of C9ORF72 Related Phenotypes

    PubMed Central

    Wang, Xin; Hao, Limin; Saur, Taixiang; Joyal, Katelyn; Zhao, Ying; Zhai, Desheng; Li, Jie; Pribadi, Mochtar; Coppola, Giovanni; Cohen, Bruce M.; Buttner, Edgar A.

    2016-01-01

    An abnormally expanded GGGGCC repeat in C9ORF72 is the most frequent causal mutation associated with amyotrophic lateral sclerosis (ALS)/frontotemporal lobar degeneration (FTLD). Both gain-of-function (gf) and loss-of-function (lf) mechanisms have been involved in C9ORF72 related ALS/FTLD. The gf mechanism of C9ORF72 has been studied in various animal models but not in C. elegans. In the present study, we described mutant C9ORF72 modeling in C. elegans and report the finding of two suppressor genes. We made transgenes containing 9 or 29 repeats of GGGGCC in C9ORF72, driven by either the hsp-16 promoters or the unc-119 promoter. Transgenic worms were made to carry such transgenes. Phenotypic analysis of those animals revealed that Phsp−16::(G4C2)29::GFP transgenic animals (EAB 135) displayed severe paralysis by the second day of adulthood, followed by lethality, which phenotypes were less severe in Phsp−16::(G4C2)9::GFP transgenic animals (EAB242), and absent in control strains expressing empty vectors. Suppressor genes of this locomotor phenotype were pursued by introducing mutations with ethyl methanesulfonate in EAB135, screening mutant strains that moved faster than EAB135 by a food-ring assay, identifying mutations by whole-genome sequencing and testing the underlying mechanism of the suppressor genes either by employing RNA interference studies or C. elegans genetics. Three mutant strains, EAB164, EAB165 and EAB167, were identified. Eight suppressor genes carrying nonsense/canonical splicing site mutations were confirmed, among which a nonsense mutation of F57A10.2/VAMP was found in all three mutant strains, and a nonsense mutation of acp-4/ACP2 was only found in EAB164. Knock down/out of those two genes in EAB135 animals by feeding RNAi/introducing a known acp-4 null allele phenocopied the suppression of the C9ORF72 variant related movement defect in the mutant strains. Translational conformation in a mammalian system is required, but our worm data

  5. A Proposal to Address NFL Club Doctors’ Conflicts of Interest and to Promote Player Trust

    PubMed Central

    Cohen, I. Glenn; Lynch, Holly Fernandez; Deubert, Christopher R.

    2016-01-01

    How can we ensure that players in the National Football League receive excellent health care they can trust from providers who are as free from conflicts of interest as realistically possible? NFL players typically receive care from the club's own medical staff. Club doctors are clearly important stakeholders in player health. They diagnose and treat players for a variety of ailments, physical and mental, while making recommendations to the player concerning those ailments. At the same time, club doctors have obligations to the club, namely to inform and advise clubs about the health status of players. While players and clubs share an interest in player health—both of them want players to be healthy so they can play at peak performance—there are several areas where their interests can diverge, and the divergence presents legal and ethical challenges. The current structure forces club doctors to have obligations to two parties—the club and the player—and to make difficult judgments about when one party's interests must yield to another's. None of the three parties involved should prefer this conflicted approach. We propose to resolve the problem of dual loyalty by largely severing the club doctor's ties with the club and refashioning that role into one of singular loyalty to the player‐patient. The main idea is to separate the roles of serving the player and serving the club and replace them with two distinct sets of medical professionals: the Players' Medical Staff (with exclusive loyalty to the player) and the Club Evaluation Doctor (with exclusive loyalty to the club). We begin by explaining the broad ethical principles that guide us and that help shape our recommendation. We then provide a description of the role of the club doctor in the current system. After explaining the concern about the current NFL player health care structure, we provide a recommendation for improving this structure. We then discuss how the club medical staff fits into the

  6. The PIP training programme: building of ACP experts capacities in crop protection and food safety to support local companies to comply with EU regulations on pesticides residues.

    PubMed

    Schiffers, B C; Schubert, A; Schiffers, C; Fontaine, S; Gumusboga, N; Werner, B; Webb, M; Lugros, H; Stinglhamber, G

    2006-01-01

    Regulatory requirements, and in particular phytosanitary quality standards change rapidly. As ACP producers/exporters race to become more competitive, to keep their market share and to satisfay their customers' commercial demands (e.g. EUREP-GAP certification), the need for competent staff who are aware of the company's quality objectives and trained to follow instructions is crucial. Mastering sanitary quality is only possible if matched with a programme to build the skills of companies' human resources. The Pesticide Initiative Programme (PIP), mindful of the importance of making operators autonomous and of training them to monitor EU food safety regulations and technology on their own, has successfully developed a training programme while building a quality network of local/ACP service providers. By building the capacities of ACP experts and then securing their services as trainers, PIP also guarantees companies' access to expertise and the sustainability of their efforts to comply with new EU regulations. The training strategy developed by PIP rests on two pilars: instructor training and collective training. Instructor training consists in reinforcing the technical knowledge of local experts (agronomists, hygienists, etc.) by providing them with active teaching methods. Once the ACP experts have gained enough technical knowledge of the key areas of crop protection--mainly pesticides management--and food safety, and have demonstrated their capacity to train the technical staff of local companies, the PIP has carried out a collective training programme in 2004, 2005 and 2006. To date, more than 130 consultants covering about 15 ACP countries have received instructor training, and more than 700 people have participated in collective and in-company training sessions.

  7. Efficacy of a novel at-home bleaching technique with carbamide peroxides modified by CPP-ACP and its effect on the microhardness of bleached enamel.

    PubMed

    Borges, B C D; Borges, J S; de Melo, C D; Pinheiro, I V A; Santos, A J S Dos; Braz, R; Montes, M A J R

    2011-01-01

    This study was designed to evaluate in vitro the efficacy of a novel at-home bleaching technique using 10% or 16% carbamide peroxide modified by casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and its influence on the microhardness of bleached enamel. A total of 40 bovine incisors were divided into four groups (n=10) according to the bleaching agent used: 10% carbamide peroxide only; a blend of 10% carbamide peroxide and a CPP-ACP paste; 16% carbamide peroxide only; and a blend of 16% carbamide peroxide and a CPP-ACP paste. During the 14-day bleaching regimen, the samples were stored in artificial saliva. The Vickers microhardness and color of the teeth were assessed at baseline (T0) and immediately after the bleaching regimen (T14) using a microhardness tester and a spectrophotometer, respectively. The degree of color change was determined by the Commission Internationale de l'Eclariage (CIE) L*a*b* system (ΔE, ΔL*, Δa*, and Δb*) and Vita shade guide parameters. The data were analyzed by analysis of variance and the Tukey test (p<0.05). The teeth that were bleached with a blend of peroxide (10% or 16%) and the CPP-ACP paste presented increased microhardness values at T14 compared with T0, whereas the samples that were bleached with peroxide only did not show any differences in their microhardness values. All of the bleaching agents were effective at whitening the teeth and did not show a statistically significant difference using the CIEL*a*b* system (ΔE, ΔL*, Δa*, and Δb*) or the Vita shade guide parameters. The use of a CPP-ACP paste with carbamide peroxide bleaching agents increased the bleached enamel's microhardness and did not have an influence on whitening efficacy.

  8. Le journal litteraire: une decouverte (The Literary Journal: A Discovery).

    ERIC Educational Resources Information Center

    Pelletier, Christine

    1999-01-01

    To encourage the students in her French class to read books in French, a teacher implemented a project involving literary journals. Students recorded their reflections on their reading, first of a novel chosen by the teacher, then of individually chosen novels. Appropriate evaluation of the journals posed a particular dilemma. (JLR)

  9. Style in medical journals.

    PubMed Central

    Adams Smith, D E

    1983-01-01

    A study of medical journals from 1962 showed a constant preoccupation with style. Editors and contributors on both sides of the Atlantic revile unnecessary obscurity and complexity and the use of jargon, barbarisms, vogue words, and weak impersonal constructions. They bewail the pompous use of verbiage and the "medspeak" typified by acronyms and neologisms created by affixation. Suggestions for possible causes of poor medical style range from editorial demands for compression and a general ignorance of the principles of good writing to faulty logic and the subordination of communication to status seeking. The consequences of bad writing may include the fragmentation of knowledge, an increase in the importance of abstracting services, a trend towards free glossy medical newspapers, and, as remedial measures, workshops and courses in medical writing. Some implications for English language teachers working with foreign medical graduates and preclinical students are discussed. PMID:6414596

  10. It Takes an Academic Village: The Library's Role in Supporting Interprofessional Communication through a Book Club.

    PubMed

    Kilham, Jessica P; Griffiths, Susan P

    2017-01-01

    Book clubs offer a unique opportunity to support interprofessional learning on academic campuses. The purpose of this article is to discuss how a health sciences library partnered with the Center for Interprofessional Healthcare Education to develop a book club that fosters interprofessional communication. The article includes a discussion of the opportunities, approach, results, and challenges.

  11. Attracting Youth to Agriculture: The Career Interests of Young Farmers Club Members in Uganda

    ERIC Educational Resources Information Center

    Mukembo, Stephen C.; Edwards, M. Craig; Ramsey, Jon W.; Henneberry, Shida R.

    2014-01-01

    This embedded, quantitative case study included 102 participants who were members of Young Farmers Clubs (YFCs) from two secondary schools in eastern Uganda. The study's multifold purpose was to describe YFC members' personal characteristics and their reasons for joining the clubs. In addition, the study sought to determine the career…

  12. Authentic Science Research in Elementary School After-School Science Clubs

    ERIC Educational Resources Information Center

    Feldman, Allan; Pirog, Kelly

    2011-01-01

    In this paper we report on teachers' and students' participation in authentic science research in out of school time science clubs at elementary schools. In the program four to five teachers worked alongside practicing scientists as part of their research groups. Each teacher facilitated a club with 10-15 students who, by extension, were members…

  13. The Washington Biologists' Field Club: Its Members and Its History (1900-2006)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This short paper is a review of book that outlines the 100-year history of the Washington Biologists' Field Club. The Club has had 267 members in its history from 1900-2006, several of which have been noted entomologists. Biographies (or autobiographies) are presented for each member, along with b...

  14. Lessons of Researcher-Teacher Co-Design of an Environmental Health Afterschool Club Curriculum

    ERIC Educational Resources Information Center

    Hundal, Savreen; Levin, Daniel M.; Keselman, Alla

    2014-01-01

    This paper addresses the impact of teachers' beliefs about argumentation and their community of practice framed views of teaching on co-designing an environmental health afterschool club curriculum with researchers. Our team collaborated with a group of four middle school teachers, asking them to co-design a club that would facilitate (1)…

  15. Conflict in a Sixth-Grade Book Club: The Impact of a Rule-Driven Discourse

    ERIC Educational Resources Information Center

    Hill, K. Dara

    2008-01-01

    This study examines unintended consequences during a 6th-grade book club discussion of Bette Bao Lord's (1984) In the Year of the Boar and Jackie Robinson. The participants modeled a book club discussion, otherwise known as the fish bowl, for a newly enrolled student. Unintended consequences occurred within the realm of deviating from the rules of…

  16. Reading Lolita in Times of War: Women's Book Clubs and the Politics of Reception

    ERIC Educational Resources Information Center

    Burwell, Catherine

    2007-01-01

    In this article I argue that women's book clubs are significant sites for learning, dialogue and the accumulation of cultural capital, and that research on North American women's book clubs should be expanded to include studies of such groups' consumption of texts by and about women living in the Middle East. Using insights from transnational…

  17. Club position relative to the golfer's swing plane meaningfully affects swing dynamics.

    PubMed

    MacKenzie, Sasho J

    2012-06-01

    Previous research indicates that the motion of the golf club is not planar and that the plane traced out by the club is different than that of the golfer's hands. The aim of the present study was to investigate how the position of the club, relative to the golfer's swing plane, influences the motion of the club by using a four-segment (torso, upper arm, forearm, and club), three-dimensional forward dynamics model. A genetic algorithm optimized the coordination of the model's four muscular torque generators to produce the best golf swings possible under six different conditions. The series of simulations were designed to demonstrate the effect of positioning the club above, and below, the golfer's swing plane as well as the effect of changing the steepness of the golfer's swing plane. The simulation results suggest that positioning the club below the golfer's swing plane, early in the downswing, will facilitate the squaring of the clubface for impact, while positioning the club above the plane will have the opposite effect. It was also demonstrated that changing the steepness of the golfer's swing plane by 10 degrees can have little effect on the delivery of the clubhead to the ball.

  18. Attitudes of Overweight and Normal Weight Adults Regarding Exercise at a Health Club

    ERIC Educational Resources Information Center

    Miller, Wayne C.; Miller, Todd A.

    2010-01-01

    Objective: To compare attitudes of overweight (OW) and normal weight (NW) adults regarding health club exercise. Design: A 46-item survey (23 pairs of attitude/value statements) measured attitudes toward exercising at a health club 30 minutes, twice a week, for a month. Setting: Survey posted on surveymonkey.com. Respondents (men = 730, women =…

  19. Creating a "Literacy Club" in a First Grade Classroom: One Teacher's Balanced Approach.

    ERIC Educational Resources Information Center

    Purcell, John

    Frank Smith (1988) describes a "literacy club" as a classroom where no child is excluded from a wealth of reading and writing activities. One teacher, in designing a literacy club for his classroom, wanted to use a "balanced literacy" approach because using such an approach would allow him to incorporate many different…

  20. The Kids' Book Club: Lively Reading and Activities for Grades 1-3.

    ERIC Educational Resources Information Center

    Webber, Desiree; Shropshire, Sandy

    Children learn to love reading by sharing quality books. Intended for children's librarians, media specialists, teachers, day care providers, and parents, this book will make it easy and fun to conduct book club meetings with little preparation time. Everything needed to start a weekly book club at school or at the library is included--detailed…

  1. No Limits--READ! Young Adult Reading Club and Programming Manual.

    ERIC Educational Resources Information Center

    Youngblood, Lisa

    This manual provides strategies for developing young adult collections, outlines a reading club designed specifically for young adults, suggests promotional ideas for the young adult reading club and young adult programming in general, and provides age-appropriate ideas for both formal and passive programming. Specific topics covered in the…

  2. 78 FR 13086 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Job Clubs...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-26

    ... support groups, commonly referred to as ``job clubs'' have evolved into one of several important... through faith-based organizations, such as church ministries; volunteer-run networking groups that meet at... little assessment and/or empirical study of volunteer-run job clubs and job search support...

  3. Self-Esteem Profile among the Female Futsal-Football Players at Jordanian Clubs

    ERIC Educational Resources Information Center

    Khasawneh, Aman

    2015-01-01

    This study aimed at identifying the level of physical and body self-esteem among the female futsal - football players at Jordanian clubs. The sample of the study was composed of (38) female players among the Jordanian clubs' players of futsal-football who were chosen randomly out of the study community, and the self-esteem scale was used,…

  4. The Clio Club: An Extracurricular Model for Elementary Social Studies Enrichment

    ERIC Educational Resources Information Center

    Morris, Ronald Vaughan

    2008-01-01

    This article describes an extracurricular social studies enrichment program called the Clio Club. "Clio" is derived from the Greek muse of history, and the club offers a variety of activities to help students discover and interpret social studies beyond the traditional school hours. They meet after school and on weekends both at their…

  5. Comprehension Right from the Start: How To Organize and Manage Book Clubs for Young Readers.

    ERIC Educational Resources Information Center

    Marriott, Donna

    Noting that book clubs offer a balanced approach that respects the highly individualized nature of learning and utilizes guided reading, shared reading, listening, speaking, writing, and critical thinking skills, this book proposes how to organize and manage book clubs for young readers. The book provides suggestions on how to accomplish the…

  6. Challenges in Offering Inner-City After-School Physical Activity Clubs

    ERIC Educational Resources Information Center

    Maljak, Kimberly; Garn, Alex; McCaughtry, Nate; Kulik, Noel; Martin, Jeffrey; Shen, Bo; Whalen, Laurel; Fahlman, Mariane

    2014-01-01

    Background: Offering physical activity clubs (PACs) for students in urban high schools can provide avenues for increased physical activity (PA); however, little is known about why some clubs are not successful. Purpose: The purpose of this qualitative study was to examine leaders' and students' perspectives on the challenges faced when…

  7. Join a Club! Or a Team--Both Can Make Good Citizens

    ERIC Educational Resources Information Center

    Levine, Peter

    2016-01-01

    Sports participation in high school has positive effects on students' later civic engagement. But that is true of nearly all forms of extracurricular participation in high school--whether a group is explicitly civic (student government or a service club) or far removed from civic life (an academic club or a music group). Indeed, the civic…

  8. 78 FR 34582 - Safety Zone; Rochester Yacht Club Fireworks, Genesee River, Rochester, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Rochester Yacht Club Fireworks, Genesee... restrict vessels from a portion of the Genesee River during the Rochester Yacht Club fireworks display... with a fireworks display. DATES: This rule will be effective between 9:30 p.m. until 11:00 p.m. on...

  9. A Leesburg, Virginia, Service Club Introduces Lithuanian Communities to American Institutions.

    ERIC Educational Resources Information Center

    Raflo, Alan

    1993-01-01

    Describes how Kiwanis club members in Leesburg, Virginia, organized a successful trip to two Lithuanian communities without government support. U.S. visitors spoke to Lithuanians about the role of small businesses and civic clubs in the United States. Possible outcomes of the trip include continuing connections between businesses and between…

  10. Community-Based English Clubs: English Practice and Social Change outside the Classroom

    ERIC Educational Resources Information Center

    Malu, Kathleen F.; Smedley, Bryce

    2016-01-01

    This article defines and provides a rationale for the creation of community-based English clubs. We offer strategies that individuals can use to create and sustain English clubs, and we suggest meeting activities that will engage members in conversations and potential community action on a range of topics such as democracy, gender equality, and…

  11. Experiential Learning for Preservice Teachers: Digital Book Clubs with Third Graders

    ERIC Educational Resources Information Center

    Stover, Katie; Yearta, Lindsay; Harris, Caroline

    2016-01-01

    This study explored how preservice teachers' knowledge and pedagogy is enhanced through participation of online book clubs with third graders. Qualitative data included pre/post interviews, reflection papers, and blog posts of book club conversations, which were all collected and analyzed. Holistic, in-depth exploration of the recurring themes and…

  12. 78 FR 40138 - Notification of Deletion of System of Records: Kid's Club Membership List (EPA-57)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ... AGENCY Notification of Deletion of System of Records: Kid's Club Membership List (EPA-57) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: The Environmental Protection Agency is deleting the system of records for the Kids Club Membership List (EPA-57) published in the Federal Register...

  13. Activist Literacies: An Analysis of the Literacy Practices of a School-Based Human Rights Club

    ERIC Educational Resources Information Center

    Collin, Ross

    2012-01-01

    In this article, I examine the literacy practices of a high school-based human rights club. I investigate how the group engages in certain kinds of textual production to sponsor and arrange advisory sessions (school-wide meetings between teachers and small groups of students). More specifically, I consider how the club adapts school genres to…

  14. "The Text Opened My Eyes": A Book Club on Teaching Writing to ELLs

    ERIC Educational Resources Information Center

    Andrei, Elena; Ellerbe, Marcie; Cherner, Todd

    2015-01-01

    This qualitative study looked at a book club for US teachers in public schools focused on teaching writing to English language learners (ELLs). To guide the study, the central research questions were: (1) What are teachers' perceptions about a book club professional development experience?; and (2) How are teachers' views about second language…

  15. Mathematics Teachers' "Learning to Notice" in the Context of a Video Club

    ERIC Educational Resources Information Center

    van Es, Elizabeth A.; Sherin, Miriam Gamoran

    2008-01-01

    This study examines changes in teachers' thinking as they participated in a video club designed to help them learn to notice and interpret students' mathematical thinking. First, we investigate changes in teachers' talk about classroom video segments before and after participation in the video club. Second, we identify three paths along which…

  16. Private Satisfactions and Public Disorders: "Fight Club," Patriarchy, and the Politics of Masculine Violence.

    ERIC Educational Resources Information Center

    Giroux, Henry A.

    2001-01-01

    Analyzes the narrative structure of the film "Fight Club," addressing its critique of consumerism and its celebration of masculinity. Addresses the representational politics that structure the movie, especially its deeply conventional views of violence, gender relations, and masculinity. Considers the role that "Fight Club" and other cultural…

  17. 33 CFR 100.1304 - Annual Seattle Yacht Club's “Opening Day” Marine Parade.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Annual Seattle Yacht Club's “Opening Day” Marine Parade. (a) Regulated area. All of Portage Bay, with the... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Annual Seattle Yacht Club's âOpening Dayâ Marine Parade. 100.1304 Section 100.1304 Navigation and Navigable Waters COAST...

  18. The Women's National Press Club: Case Study in the Professionalization of Women Journalists.

    ERIC Educational Resources Information Center

    Beasley, Maurine H.

    The Women's National Press Club (WNPC) existed in Washington, D.C., from 1919 to 1971 primarily because the National Press Club (NPC) refused to admit women. The WNPC offered mutual support in the face of male hostility. Women were virtually cut off from news sources; 20 women had Capitol press gallery privileges in 1879, but they were effectively…

  19. Marketing the Texas Reading Club: A Guide for Youth Services Specialists.

    ERIC Educational Resources Information Center

    Ash-Geisler, Viki

    This manual is designed to help youth services specialists in libraries in Texas customize their Reading Club efforts for their communities. A successful reading club requires careful thought, extensive planning, and willing and eager participants. Attracting and engaging these participants is of primary importance, as is the reason for the…

  20. Join the AMICUS Club!: Increasing High Schoolers' Social Skills in an After-School Program.

    ERIC Educational Resources Information Center

    Sodac, David G.

    1997-01-01

    This article describes a high school club for students with and without disabilities that was established to promote constructive social relationships through an after-school club format and to develop students' self-confidence, social acceptance, and peer interaction opportunities. The membership, meetings, officers, and activities of the club…

  1. Benefits of Job Clubs for Executive Job Seekers: A Tale of Hares and Tortoises

    ERIC Educational Resources Information Center

    Kondo, Christopher T.

    2009-01-01

    This qualitative research study compares the experiences of 2 groups of executive job seekers--job club members and nonmembers--through thematic analysis of open-ended interviews. The findings indicated that job club members benefited from group learning, increased accountability, networking opportunities, emotional support, helping other members,…

  2. Preterm birth alters neonatal, functional rich club organization.

    PubMed

    Scheinost, Dustin; Kwon, Soo Hyun; Shen, Xilin; Lacadie, Cheryl; Schneider, Karen C; Dai, Feng; Ment, Laura R; Constable, R Todd

    2016-07-01

    Alterations in neural networks are associated with the cognitive difficulties of the prematurely born. Using functional magnetic resonance imaging, we analyzed functional connectivity for preterm (PT) and term neonates at term equivalent age. Specifically, we constructed whole-brain networks and examined rich club (RC) organization, a common construct among complex systems where important (or "rich") nodes connect preferentially to other important nodes. Both PT and term neonates showed RC organization with PT neonates exhibiting significantly reduced connections between these RC nodes. Additionally, PT neonates showed evidence of weaker functional segregation. Our results suggest that PT birth is associated with fundamental changes of functional organization in the developing brain.

  3. [Mothers' clubs: a place for women's health care].

    PubMed

    de Senna, P A; da Fonseca, R M

    1995-04-01

    The article relates an investigation realized next to integrant of Mother's Club of the Sanitary District of Perus, in the Municipal of São Paulo. It has how aims to know the its organizational shape and the relation between locals Municipals health institutions and with other women movements. With this to intended to know the concepts about health disease from their members to verify the possibilities of intervention in coletive health. The results reveal in the conceptions of health-disease of their integrants. Observe, however, spaces to intervention in the feeling to mplify the breast-plate of the women about of the their social identity and of the woman's health.

  4. "Talk What Others Think You Can't Talk": HIV/AIDS Clubs as Peer Education in Ugandan Schools

    ERIC Educational Resources Information Center

    Norton, Bonny; Mutonyi, Harriet

    2007-01-01

    In this article, we make the case that HIV/AIDS clubs in Ugandan schools provide valuable information to students who may not have easy access to health services. As one club motto suggests, the clubs "talk what others think you can't talk". The innovative peer education methods, which include drama, popular culture and community…

  5. Use of a Job Club to Increase Self-Efficacy: A Case Study of Return to Work.

    ERIC Educational Resources Information Center

    Sterrett, Emily A.

    1998-01-01

    Links self-efficacy theory with job club methodology by presenting a case study that measured changes in self-efficacy as a result of welfare recipients' participation in a job club. The job club enhanced each of four sources of job search expectations postulated by Bandura (1977, 1982) and resulted in return to work for all participants.…

  6. Let Us Rank Journalism Programs

    ERIC Educational Resources Information Center

    Weber, Joseph

    2014-01-01

    Unlike law, business, and medical schools, as well as universities in general, journalism schools and journalism programs have rarely been ranked. Publishers such as "U.S. News & World Report," "Forbes," "Bloomberg Businessweek," and "Washington Monthly" do not pay them much mind. What is the best…

  7. Journalism and Institutional Review Boards

    ERIC Educational Resources Information Center

    Dash, Leon

    2007-01-01

    The author opposes any Institutional Review Boards (IRBs) overseeing the work of journalism professors and journalism students in any academic institution. He argues that the tendency for IRBs to require anonymity for persons interviewed immediately reduces the credibility of any journalistic story. The composition of an IRB is questioned on…

  8. Humanities Journals Confront Identity Crisis

    ERIC Educational Resources Information Center

    Howard, Jennifer

    2009-01-01

    Senior scholars, the A-list of academic publishing, seem to submit fewer unsolicited manuscripts to traditional humanities journals than they used to. The journal has become, with very few exceptions, the place where junior and midlevel scholars are placing their work. Technology and changing habits have called into question the nature of the…

  9. The Urbanization of American Journalism.

    ERIC Educational Resources Information Center

    Nord, David Paul

    1992-01-01

    Discusses the changes in journalism occurring during the growth of private enterprise in the United States. Focuses on newspapers in Chicago and other midwestern cities. Describes Joseph Pulitzer's "New York World" as the culmination of the urbanization of U.S. journalism, recognizing the development of public interdependence in a…

  10. Local Evaluation of Chemistry Journals

    ERIC Educational Resources Information Center

    Kraus, Joseph R.; Hansen, Rachel

    2008-01-01

    This paper reports on the evaluation of local usage statistics of a specific set of chemistry journals at the University of Denver in Colorado, USA. The objective of the study is to demonstrate that commercial publishers in chemistry charge considerably more for their journals than those from the non-commercial sector. There are three variables…

  11. THE Journal's 2007 Innovators: 1

    ERIC Educational Resources Information Center

    T.H.E. Journal, 2007

    2007-01-01

    Through a variety of efforts large and small, across schools, districts, and even oceans, educators are making teaching and learning alive through the pioneering use of technology. Together, they are "T.H.E. Journal"'s class of 2007 Innovators. This article presents the class of 2007 Innovators along with their profiles. They are: (1) Edith…

  12. Email Journaling for Teacher Candidates

    ERIC Educational Resources Information Center

    Jenny, Geraldine Covert

    2005-01-01

    This paper discusses email journaling for those hoping to become a teacher. The author discusses an innovative format she designed for journal entries that revolutionized her field experience supervision practices and those of other supervisors with whom she has shared this format. It has vastly improved the quality of the teacher-candidate's…

  13. Pacific Educational Research Journal, 1996.

    ERIC Educational Resources Information Center

    Berg, Kathleen F., Ed.; Lai, Morris K., Ed.

    1996-01-01

    This first issue of the new "Pacific Educational Research Journal" offers articles covering diverse subjects and using diverse research methods. The new journal represents a rejuvenation of a previous publication to address educational issues specific to the Pacific region. Ethnic groups specifically addressed include Hawaiians,…

  14. Student Journal Writing in Science.

    ERIC Educational Resources Information Center

    Ediger, Marlow

    Journal writing in science can be productive and stress basic skills. Students need to be highly motivated to engage in journal writing, and since the world of science fascinates most learners, chances for motivation are good. The subject matter to be written about needs to relate directly to the ongoing unit of study. Dramatizations, both formal…

  15. Japan Studies Association Journal, 1998.

    ERIC Educational Resources Information Center

    Speaker, Richard B., Jr., Ed.; Kawada, Louise Myers, Ed.

    1998-01-01

    This journal presents new perspectives and materials on Japan that are engaging, relatively jargon-free, and shaped so that their usefulness in a college classroom is readily apparent. The journal represents an example of the potential for genuine scholarship that lies within interdisciplinary studies. Articles are divided among three thematic…

  16. Japan Studies Association Journal, 2001.

    ERIC Educational Resources Information Center

    Reichel, Philip L., Ed.

    2001-01-01

    This journal presents new perspectives and materials on Japan that are engaging, relatively jargon-free, and shaped so that their usefulness in a college classroom is readily apparent. The journal represents an example of the potential for genuine scholarship that lies within interdisciplinary studies. Articles grouped under the topic of…

  17. Price Discrimination in Academic Journals.

    ERIC Educational Resources Information Center

    Joyce, Patrick; Merz, Thomas E.

    1985-01-01

    Analysis of price discrimination (charging different prices to different customers for same product) for 89 academic journals in 6 disciplines reveals: incidence of price discrimination rose between 1974 and 1984, increase in mean institutional (library) subscription price exceeded increase in mean individual subscription price. Journal list…

  18. Conceptions of risk in the lives of club drug-using youth.

    PubMed

    Kelly, Brian C

    2005-01-01

    This paper describes current patterns of club drug use and local conceptions of risk among New York City area youth. The data is drawn from a NIDA-funded ethnographic study of club drug initiation among "Bridge and Tunnel" youth. The paper entails an examination of the harmony and discontinuity between folk models of risk within this population and professional models of risk. The author explores how club drug-using youth conceive of risks related to club drug use, specifically ecstasy, and how such conceptions compare and contrast with current professional models of risk. These conceptions of risk are crucial to understand, as they form an informal logic by which club drug practices are guided. Ultimately, the author examines how the relationship between folk models and professional models might inform health promotion efforts targeting youth.

  19. Comparative effectiveness research: challenges for medical journals.

    PubMed

    Sox, Harold C; Helfand, Mark; Grimshaw, Jeremy; Dickersin, Kay; Tovey, David; Knottnerus, J André; Tugwell, Peter

    2010-04-28

    Editors from a number of medical journals lay out principles for journals considering publication of Comparative Effectiveness Research (CER). In order to encourage dissemination of this editorial, this article is freely available in PLoS Medicine and will be also published in Medical Decision Making, Croatian Medical Journal, The Cochrane Library, Trials, The American Journal of Managed Care, and Journal of Clinical Epidemiology.

  20. Participation in a Video Club: Influences on Teachers and Teaching

    NASA Astrophysics Data System (ADS)

    Barnhart, Tara

    This dissertation examines the development of critical colleagueship among five secondary science teachers in a semester-long video club. The design of the video club was intended to promote a focus on student thinking and experimentation with elements of ambitious science teaching. Over time, participants sustained a focus on interpreting students' disciplinary thinking using evidence and began to problematize aspects of instruction related to making student thinking visible. Some participants attempted to change instruction to gain greater access to students' disciplinary thinking while others did not. Efforts to experiment with instructional practice appeared related to alignment between participants' learning goals and curricular contexts and the goals of the professional development design. Features such as framing activities, types of artifacts used, and facilitation, interacted differently over time to influence participant learning. Analysis revealed various tensions among the elements of the learning ecology that influenced participation. Findings from this study contribute to what is known about the importance of skilled facilitation as part of a learning ecology (Cobb, Confrey, diSessa, Lehrer, & Schauble, 2003) and has implications for the design of site-based professional development with secondary teachers.

  1. Tracking club sport participation from childhood to early adulthood.

    PubMed

    Richards, Rosalina; Williams, Sheila; Poulton, Richie; Reeder, Anthony I

    2007-12-01

    This study examined the strength of tracking sport participation from childhood to early adulthood among the Dunedin Multidisciplinary Health and Development Study cohort. Participation in sport, dance, or gymnastics as part of a club or group (outside of school) was assessed at ages 7, 9, 15, 18, and 21 years. In addition to the traditionally used correlation coefficients, summary statistics (intraclass correlations; ICC) from random effect models and stability coefficients from generalized estimating equations (GEE) were calculated using all the longitudinal data and controlling for the influence of covariates on tracking strength. Correlation coefficients revealed statistically significant tracking of club sport participation (7-21 years) at low levels (r = .07-0.28). The ICC summary statistic (0.23) was consistent with this, while the GEE suggested moderate tracking (0.59). The results of this study suggest that encouraging sport participation during childhood and adolescence may result in a modest increase in the likelihood of participation later in life. However, the substantial movement into and out of sport participation observed here and in other studies cautions against relying solely on sport promotion among youth as a strategy to promote lifelong participation.

  2. Baseline Testing of the Club Car Carryall With Asymmetric Ultracapacitors

    NASA Technical Reports Server (NTRS)

    Eichenberg, Dennis J.

    2003-01-01

    The NASA John H. Glenn Research Center initiated baseline testing of the Club Car Carryall with asymmetric ultracapacitors as a way to reduce pollution in industrial settings, reduce fossil fuel consumption, and reduce operating costs for transportation systems. The Club Car Carryall provides an inexpensive approach to advance the state of the art in electric vehicle technology in a practical application. The project transfers space technology to terrestrial use via non-traditional partners, and provides power system data valuable for future space applications. The work was done under the Hybrid Power Management (HPM) Program, which includes the Hybrid Electric Transit Bus (HETB). The Carryall is a state of the art, ground up, electric utility vehicle. A unique aspect of the project was the use of a state of the art, long life ultracapacitor energy storage system. Innovative features, such as regenerative braking through ultracapacitor energy storage, are planned. Regenerative braking recovers much of the kinetic energy of the vehicle during deceleration. The Carryall was tested with the standard lead acid battery energy storage system, as well as with an asymmetric ultracapacitor energy storage system. The report concludes that the Carryall provides excellent performance, and that the implementation of asymmetric ultracapacitors in the power system can provide significant performance improvements.

  3. The New Journalism in Historical Perspective

    ERIC Educational Resources Information Center

    Jensen, Jay

    1974-01-01

    Traces the history of new journalism to the pre-Civil War era of partisan and advocacy journalism and points out that "new" types of reporting have occurred throughout the history of American journalism. (RB)

  4. Leading articles in medical journals in 1966.

    PubMed

    Stimpson, Philippa J; Marks, Daniel Jb

    2016-10-01

    The British Journal of Hospital Medicine is 50 years old. This article takes a look back at articles published during the year of its inception from the British Medical Journal, the Lancet and the Journal of the American Medical Association.

  5. Authorship policies of scientific journals.

    PubMed

    Resnik, David B; Tyler, Ana M; Black, Jennifer R; Kissling, Grace

    2016-03-01

    We analysed the authorship policies of a random sample of 600 journals from the Journal Citation Reports database. 62.5% of the journals we sampled had an authorship policy. Having an authorship policy was positively associated with impact factor. Journals from the biomedical sciences and social sciences/humanities were more likely to have an authorship policy than journals from the physical sciences, engineering or mathematical sciences. Among journals with a policy, the most frequent type of policy was guidance on criteria for authorship (99.7%); followed by guidance on acknowledgments (97.3%); requiring that authors make substantial contributions to the research (94.7%); requiring that authors be accountable for the research as a whole (84.8%); guidance on changes in authorship (77.9%); requiring that authors give final approval to the manuscript (77.6%); requiring that authors draft or critically revise the manuscript (71.7%); providing guidance on corporate authorship (58.9%); prohibiting gift, guest or ghost authorship (31.7%); requiring authors to describe their contributions (5.3%); limiting the number of authors for some types of articles (4.0%) and requiring authors to be accountable for their part in the research (1.1%). None of the policies addressed equal contribution statements. Journals that do not have authorship policies should consider adopting or developing ones.

  6. Authorship policies of scientific journals

    PubMed Central

    Resnik, David B; Tyle, Ana M; Black, Jennifer R; Kissling, Grace

    2016-01-01

    We analysed the authorship policies of a random sample of 600 journals from the Journal Citation Reports database. 62.5% of the journals we sampled had an authorship policy. Having an authorship policy was positively associated with impact factor. Journals from the biomedical sciences and social sciences/humanities were more likely to have an authorship policy than journals from the physical sciences, engineering or mathematical sciences. Among journals with a policy, the most frequent type of policy was guidance on criteria for authorship (99.7%); followed by guidance on acknowledgments (97.3%); requiring that authors make substantial contributions to the research (94.7%); requiring that authors be accountable for the research as a whole (84.8%); guidance on changes in authorship (77.9%); requiring that authors give final approval to the manuscript (77.6%); requiring that authors draft or critically revise the manuscript (71.7%); providing guidance on corporate authorship (58.9%); prohibiting gift, guest or ghost authorship (31.7%); requiring authors to describe their contributions (5.3%); limiting the number of authors for some types of articles (4.0%) and requiring authors to be accountable for their part in the research (1.1%). None of the policies addressed equal contribution statements. Journals that do not have authorship policies should consider adopting or developing ones. PMID:26714812

  7. Increasing Opportunities for Older Youth in After-School Programs. A Report on the Experiences of Boys & Girls Clubs in Boston and New York City.

    ERIC Educational Resources Information Center

    Herrera, Carla; Arbreton, Amy J. A.

    Boys & Girls Clubs in New York City and Boston participated in a 3-year initiative to provide and enhance services to underserved teens. Researchers collected data via surveys of club members and staff; cost surveys of club administrators; interviews, focus groups, and observations at each club; and attendance information. Results indicated…

  8. A [32P]-NAD+-based method to identify and quantitate long residence time enoyl-ACP reductase inhibitors

    PubMed Central

    Yu, Weixuan; Neckles, Carla; Chang, Andrew; Bommineni, Gopal Reddy; Spagnuolo, Lauren; Zhang, Zhuo; Liu, Nina; Lai, Christina; Truglio, James; Tonge, Peter J.

    2015-01-01

    The classical methods for quantifying drug-target residence time (tR) use loss or regain of enzyme activity in progress curve kinetic assays. However, such methods become imprecise at very long residence times, mitigating the use of alternative strategies. Using the NAD(P)H-dependent FabI enoyl-ACP reductase as a model system, we developed a Penefsky column-based method for direct measurement of tR, where the off-rate of the drug was determined with radiolabeled [adenylate-32P] NAD(P+) cofactor. Twenty-three FabI inhibitors were analyzed and a mathematical model was used to estimate limits to the tR values of each inhibitor based on percent drug-target complex recovery following gel filtration. In general, this method showed good agreement with the classical steady state kinetic methods for compounds with tR values of 10-100 min. In addition, we were able to identify seven long tR inhibitors (100-1500 min) and to accurately determine their tR values. The method was then used to measure tR as a function of temperature, an analysis not previously possible using the standard kinetic approach due to decreased NAD(P)H stability at elevated temperatures. In general, a 4-fold difference in tR was observed when the temperature was increased from 25 °C to 37 °C . PMID:25684450

  9. Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii.

    PubMed

    Stec, Jozef; Fomovska, Alina; Afanador, Gustavo A; Muench, Stephen P; Zhou, Ying; Lai, Bo-Shiun; El Bissati, Kamal; Hickman, Mark R; Lee, Patty J; Leed, Susan E; Auschwitz, Jennifer M; Sommervile, Caroline; Woods, Stuart; Roberts, Craig W; Rice, David; Prigge, Sean T; McLeod, Rima; Kozikowski, Alan P

    2013-07-01

    Through our focused effort to discover new and effective agents against toxoplasmosis, a structure-based drug design approach was used to develop a series of potent inhibitors of the enoyl-acyl carrier protein (ACP) reductase (ENR) enzyme in Toxoplasma gondii (TgENR). Modifications to positions 5 and 4' of the well-known ENR inhibitor triclosan afforded a series of 29 new analogues. Among the resulting compounds, many showed high potency and improved physicochemical properties in comparison with the lead. The most potent compounds 16 a and 16 c have IC50 values of 250 nM against Toxoplasma gondii tachyzoites without apparent toxicity to the host cells. Their IC50 values against recombinant TgENR were found to be 43 and 26 nM, respectively. Additionally, 11 other analogues in this series had IC50 values ranging from 17 to 130 nM in the enzyme-based assay. With respect to their excellent in vitro activity as well as improved drug-like properties, the lead compounds 16 a and 16 c are deemed to be excellent starting points for the development of new medicines to effectively treat Toxoplasma gondii infections.

  10. Expression of the heterologous Dunaliella tertiolecta fatty acyl-ACP thioesterase leads to increased lipid production in Chlamydomonas reinhardtii.

    PubMed

    Tan, Kenneth Wei Min; Lee, Yuan Kun

    2017-04-10

    Biofuel production from genetically-engineered microalgae is currently among the most widely studied strategies in generating renewable energy. However, microalgae currently suffer from low oil yields which limit the commercial feasibility of industrial-scale production. A major bottleneck in cost-efficient biofuel production from microalgae is the dilemma between biomass productivity and lipid accumulation. When grown under stressful culture conditions such as nitrogen depletion, microalgae accumulate large amounts of neutral lipids, but it comes at the expense of growth which negatively impacts overall lipid productivity. Overexpression of acyl-ACP thioesterases (TE) had been successful in increasing the production of fatty acids (FA) in prokaryotes such as E. coli and cyanobacteria, but has not been effectively tested in microalgae. In this study, we introduced a TE from D. tertiolecta (DtTE) into C. reinhardtii to investigate its effects on FA production without compromising growth. The results indicate that C. reinhardtii transformants were able to produce 63 and 94% more neutral lipids than the wild-type, which translates to an approximately 56% improvement in total lipids, without compromising growth. These findings demonstrate the cross-species functionality of TE, and provide a platform for further studies into using TE as a strategy to increase biofuel production from microalgae.

  11. Modification of Triclosan Scaffold in Search of Improved Inhibitors for Enoyl-Acyl Carrier Protein (ACP) Reductase in Toxoplasma gondii

    PubMed Central

    Stec, Jozef; Fomovska, Alina; Afanador, Gustavo A.; Muench, Stephen P.; Zhou, Ying; Lai, Bo-Shiun; Bissati, Kamal El; Hickman, Mark R.; Lee, Patty J.; Leed, Susan E.; Auschwitz, Jennifer M.; Sommervile, Caroline; Woods, Stuart; Roberts, Craig W.; Rice, David; Prigge, Sean T.; McLeod, Rima; Kozikowski, Alan P.

    2013-01-01

    Through our focused effort to discover new and effective agents against toxoplasmosis, a structure-based drug design approach was utilized to develop a series of potent inhibitors of the enoyl-acyl carrier protein (ACP) reductase (ENR) enzyme in Toxoplasma gondii (TgENR). Modifications to positions 5 and 4′ of the well-known ENR inhibitor triclosan afforded a series of 29 new analogs. Among the resulting compounds, many showed high potency and improved physicochemical properties in comparison with the lead. The most potent compounds 16a and 16c have IC50 values of 250 nM against Toxoplasma gondii tachyzoites without apparent toxicity to the host cells. Their IC50 values against the recombinant TgENR were 43 and 26 nM, respectively. Additionally, 11 other analogs in this series had IC50 values ranging from 17 to 130 nM in the enzyme-based assay. With respect to their excellent in vitro activity as well as improved drug-like properties, the lead compounds 16a and 16c are deemed to be an excellent starting point for the development of new medicines to effectively treat Toxoplasma gondii infections. PMID:23776166

  12. 3-Oxoacyl-ACP Reductase from Schistosoma japonicum: Integrated In Silico-In Vitro Strategy for Discovering Antischistosomal Lead Compounds

    PubMed Central

    Liu, Jian; Dyer, Dave; Wang, Jipeng; Wang, Shuqi; Du, Xiaofeng; Xu, Bin; Zhang, Haobing; Wang, Xiaoning; Hu, Wei

    2013-01-01

    Background Schistosomiasis is a disease caused by parasitic worms and more than 200 million people are infected worldwide. The emergence of resistance to the most commonly used drug, praziquantel (PZQ), makes the development of novel drugs an urgent task. 3-oxoacyl-ACP reductase (OAR), a key enzyme involved in the fatty acid synthesis pathway, has been identified as a potential drug target against many pathogenic organisms. However, no research on Schistosoma japonicum OAR (SjOAR) has been reported. The characterization of the SjOAR protein will provide new strategies for screening antischistosomal drugs that target SjOAR. Methodology/Principal Findings After cloning the SjOAR gene, recombinant SjOAR protein was purified and assayed for enzymatic activity. The tertiary structure of SjOAR was obtained by homology modeling and 27 inhibitor candidates were identified from 14,400 compounds through molecular docking based on the structure. All of these compounds were confirmed to be able to bind to the SjOAR protein by BIAcore analysis. Two compounds exhibited strong antischistosomal activity and inhibitory effects on the enzymatic activity of SjOAR. In contrast, these two compounds showed relatively low toxicity towards host cells. Conclusions/Significance The work presented here shows the feasibility of isolation of new antischistosomal compounds using a combination of virtual screening and experimental validation. Based on this strategy, we successfully identified 2 compounds that target SjOAR with strong antischistosomal activity but relatively low cytotoxicity to host cells. PMID:23762275

  13. Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining.

    PubMed

    Song, Lijiang; Barona-Gomez, Francisco; Corre, Christophe; Xiang, Longkuan; Udwary, Daniel W; Austin, Michael B; Noel, Joseph P; Moore, Bradley S; Challis, Gregory L

    2006-11-22

    Polyketide synthases (PKSs) are involved in the biosynthesis of many important natural products. In bacteria, type III PKSs typically catalyze iterative decarboxylation and condensation reactions of malonyl-CoA building blocks in the biosynthesis of polyhydroxyaromatic products. Here it is shown that Gcs, a type III PKS encoded by the sco7221 ORF of the bacterium Streptomyces coelicolor, is required for biosynthesis of the germicidin family of 3,6-dialkyl-4-hydroxypyran-2-one natural products. Evidence consistent with Gcs-catalyzed elongation of specific beta-ketoacyl-ACP products of the fatty acid synthase FabH with ethyl- or methylmalonyl-CoA in the biosynthesis of germicidins is presented. Selectivity for beta-ketoacyl-ACP starter units and ethylmalonyl-CoA as an extender unit is unprecedented for type III PKSs, suggesting these enzymes may be capable of utilizing a far wider range of starter and extender units for natural product assembly than believed until now.

  14. The role of club cell phenoconversion and migration in idiopathic pulmonary fibrosis

    PubMed Central

    Fukumoto, Jutaro; Soundararajan, Ramani; Leung, Joseph; Cox, Ruan; Mahendrasah, Sanjay; Muthavarapu, Neha; Herrin, Travis; Czachor, Alexander; Tan, Lee C.; Hosseinian, Nima; Patel, Priyanshi; Gone, Jayanthraj; Breitzig, Mason T.; Cho, Young; Cooke, Andrew J.; Galam, Lakshmi; Narala, Venkata Ramireddy; Pathak, Yashwant; Lockey, Richard F.; Kolliputi, Narasaiah

    2016-01-01

    Idiopathic pulmonary fibrosis (IPF) is an age-related multifactorial disease featuring non-uniform lung fibrosis. The decisive cellular events at early stages of IPF are poorly understood. While the involvement of club cells in IPF pathogenesis is unclear, their migration has been associated with lung fibrosis. In this study, we labeled club cells immunohistochemically in IPF lungs using a club cell marker Claudin-10 (Cldn10), a unique protein based on the recent report which demonstrated that the appearance of Cldn10 in developing and repairing lungs precedes other club cell markers including club cell secretory protein (CCSP). Cldn10-positive cells in IPF lungs displayed marked pleomorphism and were found in varied arrangements, suggesting their phenoconversion. These results were corroborated by immunogold labeling for Cldn10. Further, immunohistochemical double-labeling for Cldn10 and α-smooth muscle actin (α-SMA) demonstrated that aberrant α-SMA signals are frequently encountered near disorganized Cldn10-positive cells in hyperplastic bronchiolar epithelium and thickened interstitium of IPF lungs. Collectively, these data indicate that club cells actively participate in the initiation and progression of IPF through phenoconversion involving the acquisition of proliferative and migratory abilities. Thus, our new findings open the possibility for club cell-targeted therapy to become a strategic option for the treatment of IPF. PMID:27899769

  15. Radiolabelling and positron emission tomography of PT70, a time-dependent inhibitor of InhA, the Mycobacterium tuberculosis enoyl-ACP reductase.

    PubMed

    Wang, Hui; Liu, Li; Lu, Yang; Pan, Pan; Hooker, Jacob M; Fowler, Joanna S; Tonge, Peter J

    2015-11-01

    PT70 is a diaryl ether inhibitor of InhA, the enoyl-ACP reductase in the Mycobacterium tuberculosis fatty acid biosynthesis pathway. It has a residence time of 24 min on the target, and also shows antibacterial activity in a mouse model of tuberculosis infection. Due to the interest in studying target tissue pharmacokinetics of PT70, we developed a method to radiolabel PT70 with carbon-11 and have studied its pharmacokinetics in mice and baboons using positron emission tomography.

  16. Cryopreservation of collared peccaries (Tayassu tajacu) semen using a powdered coconut water (ACP-116c) based extender plus various concentrations of egg yolk and glycerol.

    PubMed

    Silva, M A; Peixoto, G C X; Lima, G L; Bezerra, J A B; Campos, L B; Paiva, A L C; Paula, V V; Silva, A R

    2012-08-01

    The objective was to determine the effectiveness of a powdered coconut water-based extender (ACP-116c), plus various concentrations of egg-yolk and glycerol, as an alternative for cryopreservation of collared peccary semen. Twelve ejaculates were obtained from captive adult males by electroejaculation, and evaluated for sperm motility, kinetic rating, viability, morphology, and functional membrane integrity. The ejaculates were apportioned into aliquots that were diluted in Tris plus 10% egg yolk and 3% glycerol, or in ACP-116c plus 10 or 20% egg yolk and 1.5 or 3% glycerol. Samples were frozen in liquid nitrogen and, after 1 mo, thawed at 37 °C for 1 min. After thawing, samples were evaluated as reported for fresh semen, and also for sperm membrane integrity (fluorescent probes) and kinematic parameters (computerized analysis). Results were presented as means ± SEM. Freezing and thawing decreased sperm characteristics relative to fresh semen. Overall, ACP-116c plus 20% egg yolk and 3% glycerol provided better (P < 0.05) sperm motility and kinetic rating (48 ± 6.1% and 2.8 ± 0.2, respectively) after thawing than Tris extender (30.4 ± 5.7% and 2.4 ± 0.2). However, there were no differences (P > 0.05) among treatments with regard to the other sperm characteristics. Based on computerized motion analysis, total (26.5 ± 5.9%) and progressive (8.1 ± 2.2%) motility were best preserved (P < 0.05) with the above-mentioned treatment. In conclusion, a coconut water-based extender, ACP-116c, plus 20% egg yolk and 3% glycerol, was effective for cryopreservation of semen from collared peccaries.

  17. Evaluation of fertilizing potential of frozen-thawed dog spermatozoa diluted in ACP-106 using an in vitro sperm--oocyte interaction assay.

    PubMed

    Cardoso, R C S; Silva, A R; Silva, L D M; Chirinéa, V H; Souza, F F; Lopes, M D

    2007-02-01

    The aim of present study was to evaluate frozen canine semen with ACP-106 (Powder Coconut Water) using an in vitro sperm--oocyte interaction assay (SOIA). Ten ejaculates from five stud dogs were diluted in ACP-106 containing 20% egg yolk, submitted to cooling in a thermal box for 40 min and in a refrigerator for 30 min. After this period, a second dilution was performed using ACP-106 containing 20% egg yolk and 12% glycerol. Samples were thawed at 38 degrees C for 1 min. Post-thaw motility was evaluated by light microscopy and by using a computer aided semen analysis (CASA). Plasma membrane integrity and sperm morphology/acrosomal status were evaluated by fluorescent probes (C-FDA/PI) and Bengal Rose respectively. Moreover, frozen-thawed semen was analysed by a SOIA. Subjective post-thaw motility was 52.0 +/- 14.8% and it was significant higher than the total motility estimated by CASA (23.0 +/- 14.8%) because this system considered the egg yolk debris as immotile spermatozoa. Although normal sperm rate and acrosomal integrity evaluated by Bengal Rose stain was 89.6 +/- 3.1% and 94.3 +/- 3.1%, respectively, post-thaw percentage of intact plasma membrane was only 35.1 +/- 14.3%. Regarding SOIA, the percentage of interacted oocytes (bound, penetrated and bound and/or penetrated) was 75.3%. Using regression analysis, it was found significant relations between some CASA patterns and data for SOIA. In conclusion, the freezing-thawing procedure using ACP-106 was efficient for maintain the in vitro fertility potential of dog spermatozoa.

  18. Radiolabelling and positron emission tomography of PT70, a time-dependent inhibitor of InhA, the Mycobacterium tuberculosis enoyl-ACP reductase

    DOE PAGES

    Wang, Hui; Liu, Li; Lu, Yang; ...

    2015-07-14

    PT70 is a diaryl ether inhibitor of InhA, the enoyl-ACP reductase in the Mycobacterium tuberculosis fatty acid biosynthesis pathway. It has a residence time of 24 min on the target, and also shows antibacterial activity in a mouse model of tuberculosis infection. Due to the interest in studying target tissue pharmacokinetics of PT70, we developed a method to radiolabel PT70 with carbon-11 and have studied its pharmacokinetics in mice and baboons using positron emission tomography.

  19. African Passages: Journaling through Archetypes.

    ERIC Educational Resources Information Center

    Spencer, Patricia

    1990-01-01

    Explores how students (through an awareness of literary archetypes and journal writing) can use African stories to cross cultures, time, and continents, making connections between their worlds and the worlds of others. (MG)

  20. Journalism Program to Fill Gap

    ERIC Educational Resources Information Center

    Goodman, Henry

    1970-01-01

    The preparation of interested and well-trained individuals for service in editorial, advertising, and management positions on rural and small town newspapers is the intent of Sampson Technical Institute's 2-year pilot journalism program. (JO)