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Sample records for acquired flatfoot deformity

  1. Plantar measurements to determine success of surgical correction of Stage IIb adult acquired flatfoot deformity.

    PubMed

    Matheis, Erika A; Spratley, E Meade; Hayes, Curtis W; Adelaar, Robert S; Wayne, Jennifer S

    2014-01-01

    Adult acquired flatfoot deformity is a degenerative disease causing medial arch dysfunction. Surgical correction has typically involved tendon reconstruction with calcaneal osteotomy; however, the postoperative changes have not been fully characterized. The present study assessed the success of surgical correction of Stage IIb adult acquired flatfoot deformity through changes in plantar pressures and patient-generated outcome scores. With Institutional Review Board approval, 6 participants were evaluated before and after surgery using pedobarography, the Foot and Ankle Outcome Score, and the Medical Outcomes Study 36-item short-form questionnaire. The plantar pressures were recorded using a TekScan HRMat(®) during walking and in a 1- and 2-foot stance. The resulting contour maps were segmented into 9 regions, with the peak pressure, normalized force, and arch index calculated. Surgical effects were analyzed using paired t tests. Postoperatively, the Foot and Ankle Outcome Score and Medical Outcomes Study 36-item short-form questionnaire scores increased significantly from 180 ± 78 to 360 ± 136 (p < .03) and 47 ± 18 to 71 ± 19 (p = .06), respectively. During the 2-foot stance, the normalized force had increased significantly in the lateral midfoot (p < .03), although no significant differences were found in peak pressures. No significant differences were observed in the 1-foot stance. During walking, the normalized force increased significantly in the lateral mid- and forefoot (p < .05). The peak pressure increased significantly in the lateral forefoot (p < .01). The arch index values demonstrated no significant changes. The increased questionnaire scores indicated that surgical correction improved the self-perceived health of the participants. Lateral shifts in the peak pressure and normalized force suggest that forefoot and midfoot loading is altered postoperatively, consistent with the goal of offloading the dysfunctional arch. Thus, the present study has

  2. Effects of Surgical Correction for the Treatment of Adult Acquired Flatfoot Deformity: A Computational Investigation

    PubMed Central

    Iaquinto, Joseph M; Wayne, Jennifer S

    2011-01-01

    Computational models of the foot/ankle complex were developed to predict the biomechanical consequences of surgical procedures that correct for Stage II adult acquired flatfoot deformity. Cadaveric leg and foot bony anatomy was captured by CT imaging in neutral flexion and imported to the modeling software. Ligaments were approximated as tension only springs attached at insertion sites. Muscle contraction of the gastrocnemius/soleus complex was simulated through force vectors and desired external loads applied to the model. Ligament stiffnesses were modified to reflect Stage II flatfoot damage, followed by integration of corrective osteotomies—medializing calcaneal osteotomy (MCO) and Evans and calcaneocuboid distraction arthrodesis (CCDA)—to treat flatfoot. Joint angles, tissue strains, calcaneocuboid contact force, and plantar loads were analyzed. The flatfoot simulation demonstrated clinical signs of disease evidenced by degradation of joint alignment. Repair states corrected these joint misalignments with MCO having greatest impact in the hindfoot, and Evans/CCDA having greatest effect in the mid- and forefoot. The lateral procedures unevenly strained plantar structures, while offloading the medial forefoot, and increased loading on the lateral forefoot, which was amplified by combining with MCO. The Evans procedure raised calcaneocuboid joint contact force to twice intact levels. Computational results are in agreement with clinical and experimental findings. The model demonstrated potential precursors to such complications as lateral tightness and arthritic development and may thus be useful as a predictor of surgical outcomes. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 29: 1047–1054, 2011 PMID:21319218

  3. Spring Ligament Complex and Posterior Tibial Tendon: MR Anatomy and Findings in Acquired Adult Flatfoot Deformity.

    PubMed

    Mengiardi, Bernard; Pinto, Clinton; Zanetti, Marco

    2016-02-01

    The spring ligament complex is an important stabilizer of the medial ankle, together with the posterior tibial tendon (PTT) and the deltoid ligament complex. Lesions in these stabilizers result in acquired adult flatfoot deformity. The spring ligament complex includes three ligaments: the superomedial calcaneonavicular ligament, the medioplantar oblique calcaneonavicular ligament, and the inferoplantar longitudinal calcaneonavicular ligament. Normal MR imaging anatomy of the spring ligament complex and the PTT are described and illustrated in detail. Isolated lesions of the spring ligament complex are rare. In most cases, spring ligament complex lesions are secondary to PTT dysfunction. The best criteria for an injury of the clinically relevant superomedial calcaneonavicular ligament are increased signal on proton-density or T2-weighted sequences with thickening (> 5 mm), thinning (< 2 mm), or partial or complete discontinuity. A thickened ligament can be simulated by the gliding layer between the PTT and the superomedial calcaneonavicular ligament (thickness: 1-3 mm). The most common location of injury is the superior and distal portion of the superomedial calcaneonavicular ligament. A lesion seen by the orthopedic foot surgeon at the junction between the tibiospring ligament and the superomedial portion of the calcaneonavicular ligament is commonly classified as a spring ligament injury. In addition, an overview of MR imaging findings in different stages of the acquired adult flatfoot deformity is provided.

  4. OPTIMAL POSITION OF THE HEEL FOLLOWING RECONSTRUCTION OF THE STAGE II ADULT ACQUIRED FLATFOOT DEFORMITY

    PubMed Central

    Conti, Matthew S.; Ellis, Scott J.; Chan, Jeremy Y.; Do, Huong T.; Deland, Jonathan T.

    2016-01-01

    Background While previous work has demonstrated a linear relationship between the amount of medializing calcaneal osteotomy (MCO) and the change in radiographic hindfoot alignment following reconstruction, an ideal postoperative hindfoot alignment has yet to be reported. The aim of this study was to identify an optimal postoperative hindfoot alignment by correlating radiographic alignment with patient outcomes. Methods Fifty-five feet in 55 patients underwent flatfoot reconstruction for stage II AAFD by two fellowship-trained foot and ankle orthopedic surgeons. Hindfoot alignment was determined as previously described by Saltzman and El-Khoury. Changes in pre- and postoperative scores in each FAOS subscale were calculated for patients in postoperative hindfoot valgus (≥0 mm valgus, n=18), mild varus (>0 to 5 mm varus, n=17), and moderate varus (>5 mm varus, n=20). Analysis of variance and post-hoc Tukey’s tests were used to compare the change in FAOS scores between these three groups. Results At 22 months or more postoperatively, patients corrected to mild hindfoot varus showed a significantly greater improvement in the FAOS pain subscale compared to patients in valgus (p=0.04) and symptoms subscale compared to patients in moderate varus (p=0.03). Although mild hindfoot varus did not differ significantly from moderate varus or valgus in the other subscales, mild hindfoot varus did not perform worse than these alignments in any FAOS subscale. No statistically significant correlations between intraoperative MCO slide distances and FAOS subscales were found. Conclusions Our study indicates that correction of hindfoot alignment to between 0 and 5 mm of varus on the hindfoot alignment view (clinically a straight heel) following stage II flatfoot reconstruction was associated with the greatest improvement in clinical outcomes following hindfoot reconstruction in stage II AAFD. PMID:25948692

  5. 2014 Leonard Goldner Award Winner: Correlation of Postoperative Midfoot Position with Patient Outcomes Following Reconstruction of the Stage II Adult Acquired Flatfoot Deformity

    PubMed Central

    Conti, Matthew S.; Chan, Jeremy Y.; Do, Huong T.; Ellis, Scott J.; Deland, Jonathan T.

    2016-01-01

    Background No studies investigating the effect of midfoot (talonavicular joint) position on clinical outcomes following flatfoot reconstruction have been performed. The purpose of our study was to determine whether a postoperative abducted or adducted forefoot alignment, as determined from AP radiographs, was associated with a difference in outcomes using the Foot and Ankle Outcome Score (FAOS). Methods Midfoot abduction was defined on postoperative AP radiographs, evaluated at a mean of 1.9 years in 55 patients from the authors’ institution that underwent flatfoot reconstruction for stage II adult acquired flatfoot deformity (AAFD), as a lateral incongruency angle greater than 5 degrees, a talonavicular uncoverage angle greater than 8 degrees, and a talo-first metatarsal angle greater than 8 degrees based on previously reported measurements. Patients with two or more measurements in the abduction category were classified as the abduction group (n=30); those with one or fewer measurements in the abduction category were placed in the adduction group (n=25). Preoperative FAOS and postoperative FAOS with a mean follow-up of 3.1 years were compared using Wilcoxon rank-sum tests. Results Patients corrected to a position of adduction showed a significantly lower improvement in the FAOS daily activities (p=0.012) and quality of life subscales (p=0.046). Mean improvement in subscale score for the adducted group was lower for pain (p=0.052) and sports activities (p=0.085) but did not reach statistical significance. No significant difference in the FAOS symptoms subscale (p=0.372) between groups was found. Conclusions Correction of the talonavicular joint to a position of adduction following stage II AAFD is associated with decreased patient outcomes in daily activities and quality of life compared with an abducted position. These results suggest that overcorrection to a position of midfoot adduction leads to a lesser amount of individual patient improvement in the

  6. Lateral column lengthening for acquired adult flatfoot deformity caused by posterior tibial tendon dysfunction stage II: a retrospective comparison of calcaneus osteotomy with calcaneocuboid distraction arthrodesis.

    PubMed

    Haeseker, Guus A; Mureau, Marc A; Faber, Frank W M

    2010-01-01

    In this study, clinical and radiological results after lateral column lengthening by calcaneocuboid distraction arthrodesis and calcaneus osteotomy were compared. Thirty-three patients (35 feet) treated with lateral column lengthening by distraction arthrodesis (14 patients, 16 feet; group I) or by calcaneus osteotomy (19 patients, 19 feet; group II) for adult-acquired flatfoot deformity caused by stage II posterior tibial tendon dysfunction were compared retrospectively. Mean follow-up was 42.4 months (range, 6-78 months) for group I and 15.8 months (range, 6-32 months) for group II (P < .001). The American Orthopaedic Foot & Ankle Society ankle-hindfoot score was determined, 4 variables were measured on preoperative and postoperative weight-bearing radiographs, and a number of independent and outcome variables, including patient satisfaction, were recorded. Group 2 had a significantly higher American Orthopaedic Foot & Ankle Society score compared with group I (mean, 85 vs. 72, respectively; P < .02) at time of last follow-up, and there were no dissatisfied patients in group I, whereas 2 patients in group II were dissatisfied with the result of the operation. All radiological results were significantly better at time of follow-up in both groups (except for talocalcaneal angle in group I), although no significant differences were noted in the amount of change in radiographic measurements between the groups. No significant correlation was found between follow-up time and radiographic improvement, indicating stable radiographic measurements over time. In group II, 13 mild calcaneocuboid subluxations were observed. In both groups, 1 nonunion and 1 wound complication occurred. Based on our experience with the patients described in this report, we recommend lateral column lengthening by means of calcaneus osteotomy rather than distraction arthrodesis of the calcaneocuboid joint, for correction of stage II posterior tibial tendon dysfunction.

  7. Demographic, physical, and radiographic factors associated with functional flatfoot deformity.

    PubMed

    Shibuya, Naohiro; Kitterman, Ryan T; LaFontaine, Javier; Jupiter, Daniel C

    2014-01-01

    In 1 of our previous studies, the occurrence of self-reported flatfoot was associated with self-reported increased age, male gender, Asian and African American races, veteran status, poor health, increased body mass index, callus, bunion, hammertoe, and arthritis. However, we had to rely on survey data to identify these risk factors, and the accuracy of the survey results was unknown. Therefore, we decided to identify the risk factors associated with flatfeet using objectively and more accurately measured data. A total of 94 patients were enrolled in the present study. The demographic data and physical and radiographic examination results were recorded by the investigators in the clinic. The data were then analyzed to identify the factors unique to flatfoot, measured and defined using a plantar pressure measurement system during natural gait. We learned that a painful tibialis posterior tendon was associated with flatfoot. The calcaneal inclination angle was also decreased in the flatfoot group. The talar declination, intermetatarsal, hallux abductus, and calcaneal cuboid angles, and static calcaneal stance eversion were elevated in the flatfoot group compared with the non-flatfoot group. Systematic evaluation of these associated factors will help in the understanding of the functional status of the flatfoot deformity.

  8. Flexible flatfoot

    PubMed Central

    Atik, Aziz; Ozyurek, Selahattin

    2014-01-01

    While being one of the most frequent parental complained deformities, flatfoot does not have a universally accepted description. The reasons of flexible flatfoot are still on debate, but they must be differentiated from rigid flatfoot which occurs secondary to other pathologies. These children are commonly brought up to a physician without any complaint. It should be kept in mind that the etiology may vary from general soft tissue laxities to intrinsic foot pathologies. Every flexible flatfoot does not require radiological examination or treatment if there is no complaint. Otherwise further investigation and conservative or surgical treatment may necessitate. PMID:28058304

  9. A mid-term follow-up of Koutsogiannis’ osteotomy in adult-acquired flatfoot stage II and “early stage III”

    PubMed Central

    Arvinius, Camilla; Manrique, Elena; Urda, Antonio; Cardoso, Zulema; Galeote, Jose Enrique; Marco, Fernando

    2017-01-01

    Introduction: Koutsogiannis’ osteotomy has been widely described to treat adult-acquired flatfoot. However, few articles describe its midterm follow-up. Our aim was to study clinical and radiological outcomes at least one year after surgery and to analyze whether a combined procedure on the medial soft tissue affected these outcomes. Methods: We performed a retrospective study of 30 feet of patients who underwent a Koutsogiannis’ osteotomy due to adult-acquired flatfoot stage II and “early stage III”: a stage III acquired flatfoot without any important structural deformities. The parameters studied were additional medial soft tissue procedures, clinical outcome through the American Orthopaedic Foot and Ankle Society (AOFAS) ankle and midfoot score as well as complications and radiological measurements. Results: Sixteen cases were “early stage III” and 14 stage II. Thirteen patients underwent an associated posterior tibial tendon (PTT) revision: in three cases an end-to-end suture was possible, seven cases needed a FDL transposition, and three underwent synovectomy. Statistically significant improvement was found in the AOFAS score although no significant changes were seen radiologically. No additional benefit was found with the revision of the posterior tibial tendon. As to clinical and radiological results, no differences were found between stage II and “early stage III”. Five cases presented a mild dysesthesia but only one patient needed neurolysis. Conclusions: We consider the Koutsogiannis’ osteotomy to be a safe and effective procedure to reduce pain in patients with stage II and “early stage III” adult-acquired flatfoot. PMID:28304274

  10. Is there a role for subtalar arthroereisis in the management of adult acquired flatfoot?

    PubMed

    Fernández de Retana, Pablo; Alvarez, Fernando; Bacca, Gustavo

    2012-06-01

    Subtalar arthroereisis, often combined with Achilles tendon lengthening, is a simple and effective way to treat flexible flatfoot in adults. The most common complication is pain in sinus tarsi, which usually disappears after removal of the implant. Midterm results are good and it does not hinder other treatments in the future.

  11. Effect of therapeutic insoles on the medial longitudinal arch in patients with flatfoot deformity: a three-dimensional loading computed tomography study

    PubMed Central

    Kido, Masamitsu; Ikoma, Kazuya; Hara, Yusuke; Imai, Kan; Maki, Masahiro; Ikeda, Takumi; Fujiwara, Hiroyoshi; Tokunaga, Daisaku; Inoue, Nozomu; Kubo, Toshikazu

    2014-01-01

    Background Insoles are frequently used in orthotic therapy as the standard conservative treatment for symptomatic flatfoot deformity to rebuild the arch and stabilize the foot. However, the effectiveness of therapeutic insoles remains unclear. In this study, we assessed the effectiveness of therapeutic insoles for flatfoot deformity using subject-based three-dimensional (3D) computed tomography (CT) models by evaluating the load responses of the bones in the medial longitudinal arch in vivo in 3D. Methods We studied eight individuals (16 feet) with mild flatfoot deformity. CT scans were performed on both feet under non-loaded and full-body-loaded conditions, first with accessory insoles and then with therapeutic insoles under the same conditions. Three-dimensional CT models were constructed for the tibia and the tarsal and metatarsal bones of the medial longitudinal arch (i.e., first metatarsal bone, cuneiforms, navicular, talus, and calcaneus). The rotational angles between the tarsal bones were calculated under loading with accessory insoles or therapeutic insoles and compared. Findings Compared with the accessory insoles, the therapeutic insoles significantly suppressed the eversion of the talocalcaneal joint. Interpretation This is the first study to precisely verify the usefulness of therapeutic insoles (arch support and inner wedges) in vivo. PMID:25457972

  12. Double calcaneal osteotomy with percutaneous Steinmann pin fixation as part of treatment for flexible flatfoot deformity: a review of consecutive cases highlighting our experience with pin fixation.

    PubMed

    Boffeli, Troy J; Abben, Kyle W

    2015-01-01

    Surgical correction of flexible flatfoot deformity and posterior tibial tendon dysfunction has been extensively reported in published studies. When appropriate, calcaneal osteotomies for flatfoot correction have been a favorite of foot and ankle surgeons because of the corrective power achieved without the need to fuse any rearfoot joints. The medial displacement calcaneal osteotomy and Evans calcaneal osteotomy, together termed the double calcaneal osteotomy, have been reported several times by various investigators with a wide variety of fixation options. We undertook an institutional review board-approved retrospective review of 9 consecutive patients (11 feet), who had undergone double calcaneal osteotomy with 2 percutaneous Steinmann pin fixation for the correction of flexible flatfoot deformity, with or without posterior tibial tendon dysfunction. All patients had radiographic evidence of bone healing of the posterior calcaneal osteotomy and incorporation of the Evans osteotomy bone graft at 6 weeks and demonstrated clinical healing at 6 weeks. All patients had 2 percutaneous Steinmann pins placed through both osteotomies, and these were removed an average of 6 weeks postoperatively. No patient developed pin site complications. The only complication noted was sural neuritis, which was likely incision related. No patients had delayed union or nonunion, and we did not identify any graft shifting postoperatively. The present retrospective series highlights our experience with 2 percutaneous Steinmann pin fixation, demonstrating equal or better results than many previous published fixation methods for double calcaneal osteotomy. It is cost-effective and minimizes the potential risk of iatrogenic Achilles pathologic features associated with screw fixation.

  13. Acquired nasal deformities in fighter pilots.

    PubMed

    Schreinemakers, Joyce R C; van Amerongen, Pieter; Kon, Moshe

    2010-07-01

    Fighter pilots may develop slowly progressive deformities of their noses during their flying careers. The spectrum of deformities that may be acquired ranges from soft tissue to osseous changes. The main cause is the varying pressure exerted by the oxygen mask on the skin and bony pyramid of the nose during flying.

  14. How to approach the pediatric flatfoot

    PubMed Central

    Vulcano, Ettore; Maccario, Camilla; Myerson, Mark S

    2016-01-01

    The most difficult aspect regarding treatment of the pediatric flatfoot is understanding who needs surgery, when it is necessary, and what procedure to be done. A thorough history, clinical examination, and imaging should be performed to guide the surgeon through an often complex treatment path. Surgical technique can be divided in three categories: Soft tissue, bony, and arthroereisis. This paper will describe the joint preserving techniques and their application to treat the pediatric flatfoot deformity. PMID:26807350

  15. Flexible flatfoot in children and adolescents.

    PubMed

    Mosca, Vincent S

    2010-04-01

    Flexible flatfoot is a normal foot shape that is present in most infants and many adults. The arch elevates spontaneously in most children during the first decade of life. There is no evidence that a longitudinal arch can be created in a child's foot by any external forces or devices. Flexible flatfoot with a short Achilles tendon, in contrast to simple flexible flatfoot, is known to cause pain and disability in some adolescents and adults. Joint-preserving, deformity-correcting surgery is indicated in flexible flatfeet with short Achilles tendons when conservative measurements fail to relieve pain under the head of the plantar flexed talus or in the sinus tarsi area. Osteotomy is the fundamental and central procedure of choice. In almost all cases, Achilles tendon lengthening is required. In some cases, rigid supination deformity of the forefoot is present, requiring identification and concurrent treatment.

  16. Lengthening osteotomy of the calcaneus and flexor digitorum longus tendon transfer in flexible flatfoot deformity improves talo-1st metatarsal-Index, clinical outcome and pedographic parameter.

    PubMed

    Richter, Martinus; Zech, Stefan

    2013-03-01

    Lengthening osteotomy of the calcaneus (LO) and flexor digitorum longus tendon (FDL) transfer to the navicular is one option for the treatment of flexible flatfoot deformity (FD). The aim of the study was to analyse the amount of correction and clinical outcome including pedographic assessment. In a prospective consecutive non-controlled clinical followup study, all patients with FD that were treated with LO and FDL from September 1st 2006 to August 31st, 2009 were included. Assessment was performed before surgery and at 2-year-followup including clinical examination (with staging of posterior tibialis insufficiency) weight bearing radiographs (Talo-1st metatarsal angles (TMT)), pedography (increased midfoot contact area and force) and Visual Analogue Scale Foot and Ankle (VAS FA). 112 feet in 102 patients were analysed (age, 57.6 (13-82), 42% male). In 12 feet (9%) wound healing delay without further surgical measures was registered. All patients achieved full weight bearing during the 7th postoperative week. Until followup, revision surgery was done in 3 patients (fusion calcaneocuboid joint (n=2), correction triple arthrodesis (n=1)). 101 feet (90%) completed 2-year-followup. TMT dorsoplantar/lateral/Index and VAS FA scores were increased, and posterior tibialis insufficiency stage, pedographic midfoot contact area and force percentage were decreased (each p<.05). All relevant parameters (stage of posterior tibialis insufficiency, TMT angles and Index, pedographic midfoot contact area and force percentage, VAS FA) were improved 2 years after LO and FDL transfer to the navicular in FD. The complication rate was low. This method allows safe and predictable correction.

  17. Effects of orthotic insoles on adults with flexible flatfoot under different walking conditions

    PubMed Central

    Zhai, Jun Na; Qiu, Yu Sheng; Wang, Jue

    2016-01-01

    [Purpose] This study was to evaluate the effects of orthotics on adults with flexible flatfoot when wearing orthotic insoles while walking on horizontal ground, walking up and down stairs and to determine if flexible flatfoot needs treatment. [Subjects and Methods] Fifteen college students with flexible flatfoot and fifteen college students with normal feet were recruited. First, load rate and contact area were measured by RSscan force plate when the subjects were walking on horizontal ground, walking up and down 10 cm and 20 cm stairs. Then the subjects with flexible flatfoot were instructed to wear orthotic insoles for 3 months, and plantar pressure was measured again. Finally, the data were subjected to repeated measures ANOVA. [Results] After treatment for 3 months, the plantar pressure of flatfoot was significantly improved. In addition, the data of the subjects with normal feet and flatfoot were significantly influenced by walking down 10 cm or 20 cm stairs. [Conclusion] Orthotic insoles could significantly improve the plantar pressure of flatfoot. Additionally, the arches of subjects with normal feet and flatfoot can be significantly deformed when walking down stairs. Therefore, it is essential for subjects with flexible flatfoot to wear orthotic insoles to avoid needless injury. PMID:27942124

  18. Management of idiopathic and nonidiopathic flatfoot.

    PubMed

    Frances, Jenny M; Feldman, David S

    2015-01-01

    Flatfoot in a child may be normal before development of the arch, but the prevalence decreases with age. Treatment is indicated only in the presence of pain and should begin with nonsurgical management options such as stretching of the Achilles tendon and the use of soft shoe orthotics. If pain persists, a modified Evans procedure, together with additional procedures to address forefoot supination, can be successful in correcting deformity and addressing pain. A thorough understanding of the pathology and correction desired will help minimize complications and recurrence. If neuromuscular pathology is present, treatment principles are altered and greatly depend on the severity of the deformity, the association of tibialis posterior spasticity, and ambulatory status. In mild to moderate pathology in walking patients with cerebral palsy, osteotomies can be successful. Various forms of arthrodesis can decrease recurrence when the deformity is severe in a nonambulatory patient with cerebral palsy and a symptomatic valgus foot deformity. In cases of collagen disorders, where soft-tissue laxity complicates management, deformity correction may be of higher importance. Overall alignment always should be evaluated and corrected when necessary to optimize the outcome in patients with valgus foot deformities. The successful treatment of flexible or rigid flatfoot deformity must take into account underlying pathology to optimize outcomes.

  19. The etiology of primary femoroacetabular impingement: genetics or acquired deformity?

    PubMed

    Packer, Jonathan D; Safran, Marc R

    2015-10-01

    The etiology of primary femoroacetabular impingement (FAI) remains controversial. Both genetic and acquired causes have been postulated and studied. While recent studies suggest that genetic factors may have a role in the development of FAI, there is no conclusive evidence that FAI is transmitted genetically. Currently, the most popular theory for the development of cam-type deformities is that a repetitive injury to the proximal femoral physis occurs during a critical period of development. There is a correlation between a high volume of impact activities during adolescence and the development of cam-type deformities. Multiple studies have found a high prevalence of FAI in elite football, ice hockey, basketball and soccer players. In this article, we review the current literature relating to the etiology of primary FAI.

  20. Symptomatic flexible flatfoot in adults: subtalar arthroereisis

    PubMed Central

    Ozan, Fırat; Doğar, Fatih; Gençer, Kürşat; Koyuncu, Şemmi; Vatansever, Fatih; Duygulu, Fuat; Altay, Taşkın

    2015-01-01

    Flexible flatfoot is a common deformity in pediatric and adult populations. In this study, we aimed to evaluate the functional and radiographic results of subtalar arthroereisis in adult patients with symptomatic flexible flatfoot. We included 26 feet in 16 patients who underwent subtalar arthroereisis for symptomatic flexible flatfoot. Radiographic examination included calcaneal inclination angle, lateral talocalcaneal angle, Meary’s angle, anteroposterior talonavicular angle, and Kite’s angle. The clinical assessment was based on the American Orthopaedic Foot and Ankle Society (AOFAS) hindfoot scale and a visual analog scale (VAS). The mean follow-up was 15.1±4.7 months. The mean preoperative AOFAS score was 53±6.6, while the mean AOFAS score at the last follow-up visit was 75±11.2 (P<0.05). The mean visual analog scale score was 6.9±0.6 preoperatively and 4.1±1.4 at the last follow-up visit (P<0.05). The mean preoperative and postoperative values measured were 13.4°±3.3° and 14.6°±2.7° for calcaneal inclination angles (P<0.05); 35.7°±6.9° and 33.2°±5.3° for lateral talocalcaneal angles (P>0.05); 8°±5.3° and 3.3±3 for Meary’s angles (P<0.05); 5.6°±3.5° and 2.6°±1.5° for anteroposterior talonavicular angles (P<0.05); and 23.7°±6.1° and 17.7°±5° for Kite’s angles, respectively (P<0.05). Implants were removed in three feet (11.5%). Subtalar arthroereisis is a minimally invasive procedure that can be used in the surgical treatment of adults with symptomatic flexible flatfoot. This procedure provided radiological and functional recovery in our series of patients. PMID:26527876

  1. Injury Patterns and Reconstruction in Acquired Ear Deformities.

    PubMed

    Stewart, Kenneth; Majdak-Paredes, Ewa

    2015-12-01

    Reconstruction following ear trauma presents a heterogeneous group of abnormalities with significantly more variation in presentation. The aim of the study was to analyze our experience and expound some broad principles of auricular reconstruction in acquired ear deformities. A total of 117 patients with human, animal bites and revision otoplasty presented to our clinic. Demographic data were extracted from medical records and photographs. Management options included no reconstruction, external silicone prosthesis, or autologous reconstruction. Fifty percent of patients with human bite injuries and 62% with animal bite injuries opted for autologous ear reconstruction. A flap with either a costal cartilage framework (37/39; 95%) or conchal cartilage (2/39; 5%) was used. In revision otoplasty group, 12% required autologous reconstruction either with conchal or costal cartilage. We discuss our indications, techniques, complications, and predictable pattern of injuries in human bites. Autologous auricular reconstruction of traumatic injuries is a safe procedure associated with aesthetically pleasing outcome and improved quality of life despite physical and psychosocial comorbidities. Elderly patients are more likely to opt for prosthetic camouflage.

  2. Peritalar destabilisation syndrome (adult flatfoot with degenerative glenopathy).

    PubMed

    Pisani, Giacomo

    2010-12-01

    In cases of adult acquired flatfoot associated with peritalar destabilisation, special reference is made to the plantar calcaneo-navicular (spring) ligament's degenerative disease (degenerative glenopathy) and to the presence of the accessory navicular bone as a possible pathogenic cause. Peritalar destabilization syndrome is proposed for the articular (subtalar and talo-navicular joints) or tendinosis (tibialis posterior tendon) separately or in association with degenerative glenopathy of the coxa pedis. In degenerative glenopathy surgical reconstruction of the glenoid also makes use of a posterior tibial split to create a new tibial-navicular ligament. The concept of pronatory syndrome deemed as the root the pathological subtalar pronation, which is an entirely secondary factor in peritalar destabilisation, must be questioned. We must keep in mind that subtalar pronation and supination are respectively subsequent to opening and closing of the coxa pedis (talo-calcaneo-navicular joint) kinetic chain.

  3. Tripod Index: Diagnostic Accuracy in Symptomatic Flatfoot and Cavovarus Foot: Part 2

    PubMed Central

    Arunakul, Marut; Amendola, Annunziato; Gao, Yubo; Goetz, Jessica E.; Femino, John E.; Phisitkul, Phinit

    2013-01-01

    Background The Tripod Index (TI) has been created to allow assessment of complex foot deformities. It utilizes tripod relationship between center of the heel, medial/lateral borders of the forefoot, and compare it to the center of the talar head. This study aimed to verify diagnostic accuracy of the TI in symptomatic flatfoot and cavovarus foot. Methods Weightbearing radiographs including foot AP with a hemispherical marker around the heel, lateral, and hindfoot alignment views were obtained on 91 patients (110 feet) presenting with medial foot and ankle pain and on 89 patients (90 feet) presenting with lateral foot and ankle pain between June 2010 and May 2011. Radiographs were evaluated blindly for the TI, AP talonavicular coverage angle, lateral talo-first metatarsal angle, calcaneal pitch angle, medial cuneiform-fifth metatarsal height, and coronal plane hindfoot alignment. The sensitivity, specificity, likelihood ratios, and predictive values were calculated. Clinically diagnosed flatfoot and cavovarus foot deformity indicated for surgical reconstruction by one of our foot and ankle orthopaedic surgeons was used as the accepted standard for diagnosis. Results In flatfoot, sensitivity of the TI was 100%, comparable with lateral talo-first metatarsal angle (100%), and medial cuneiform-fifth metatarsal height (100%). Specificity of the TI was 93%, comparable with coronal plane hindfoot alignment (98%), but superior to other parameters. Positive likelihood ratio of the TI was 14.29, which was less than coronal plane hindfoot alignment (47.5), but more than other parameters. In cavovarus foot, sensitivity of the TI was 96%, comparable with coronal plane hindfoot alignment (100%), but superior to other parameters. Specificity of the TI was 95%, comparable with lateral talo-first metatarsal angle (94%), but superior to other parameters. Positive likelihood ratio of the TI was 19.2, which was more than other parameters. Conclusion The Tripod Index showed high accuracy

  4. Pediatric Flexible Flatfoot; Clinical Aspects and Algorithmic Approach

    PubMed Central

    Halabchi, Farzin; Mazaheri, Reza; Mirshahi, Maryam; Abbasian, Ladan

    2013-01-01

    Flatfoot constitutes the major cause of clinic visits for pediatric foot problems. The reported prevalence of flatfoot varies widely due to numerous factors. It can be divided into flexible and rigid flatfoot. Diagnosis and management of pediatric flatfoot has long been the matter of controversy. Common assessment tools include visual inspection, anthropometric values, footprint parameters and radiographic evaluation. Most flexible flatfeet are physiologic, asymptomatic, and require no treatment. Otherwise, the physician should treat symptomatic flexible flatfeet. Initial treatment options include activity modification, proper shoe and orthoses, exercises and medication. Furthermore, comorbidities such as obesity and ligamenous laxity should be identified and managed, if applicable. When all nonsurgical treatment options faile, surgery can be considered. Our purpose in this article is to present a clinical algorithmic approach to pediatric flatfoot. PMID:23795246

  5. The natural history and pathophysiology of flexible flatfoot.

    PubMed

    Harris, Edwin J

    2010-01-01

    The frequent occurrence of flexible flatfoot raises the question of its pathologic status. There may be cultural overtones resulting in the consideration that flat feet are always pathologic. Parents may believe that their own flat feet were successfully treated when they were children and wish the same for their offspring. Few studies attempt to answer the question of the natural history of this condition. This article reviews the available literature dealing with the natural history, comorbidities, recommendations for treatment, expansion of biomechanical theory, and classification of flatfoot. Issues associated with imaging of flatfoot and the design of studies to validate the effects of treatment are also reviewed.

  6. Treatment of painful pediatric flatfoot with Maxwell-Brancheau subtalar arthroereisis implant a retrospective radiographic review.

    PubMed

    Scharer, Brandon M; Black, Brian E; Sockrider, Nathan

    2010-04-01

    The purposes of this study were to evaluate the outcome of pediatric patients who have undergone Maxwell-Brancheau arthroereisis (MBA) subtalar implants for the treatment of painful pediatric flatfoot deformities. In a retrospective study, 39 patients (68 feet) were evaluated clinically and radiographically. The mean age of the patients was 12 years (range, 6-16 years). The mean period of follow-up was 24 months (range, 6-61 months). Statistical evaluation was performed on all radiographic measurements. Additional surgical procedures (gastrocnemius recession, Achilles tendon lengthening, Kidner posterior tibial tendon advancement) were performed in 22 of 68 feet. There were 10 (15%) complications, which consisted of 10 reoperations in 10 feet. Implants were exchanged in 9 feet because of implant migration, undercorrection, and overcorrection. There was 1 reoperation (in 1 foot) for implant removal because of persistent sinus tarsi pain. Radiographic evaluation demonstrated an improvement of all parameters determined. The parameters that were evaluated include talonavicular joint coverage, as well as lateral and anterior-posterior talocalcaneal angles. There were significant changes noted in pre- and postoperative measurements (P < .001). The MBA implant is effective for the correction of painful, flexible flatfoot deformity in children in short-term follow-up. However, this is a multiplanar deformity, and additional procedures may be needed in addition to the MBA.

  7. A measurement setup for acquiring the local magnetic properties of plastically deformed soft magnetic materials

    SciTech Connect

    Bi Shasha; Sutor, Alexander; Lerch, Reinhard; Xiao Yunshi

    2011-04-01

    This paper introduces a new measurement setup for extraction of the local magnetic properties. With the help of finite element method simulations, modifications are made on the previous double-C-yoke method. Small dimension measuring coils are applied in the stray field produced by the magnetic circuit to evaluate the local magnetic properties of the specified part of the specimen. Through the measurements with the plastically deformed materials at different temperatures, it indicates that the magnetic properties of soft magnetic materials are quite sensitive to plastic straining. After high-temperature thermal treatment on the plastically deformed specimen, the local magnetic properties exhibit an obvious recovery.

  8. The role of Taylor Spatial Frame for the treatment of acquired and congenital tibial deformities in children.

    PubMed

    Tsibidakis, H; Kanellopoulos, A D; Sakellariou, V I; Soultanis, K Ch; Zoubos, A B; Soucacos, P N

    2014-09-01

    This study evaluates the use of the Taylor Spatial Frame (TSF) for the correction of acquired and congenital tibial deformities in children. The purpose is to underline problems, obstacles and complications that can be observed during treatment to reveal the learning curve and potential risk factors and to propose solutions to avoid difficulties during its use 86 tibia deformities were corrected in 66 children during a period of 7 years and were classified according to anatomical and dominant type of deformity. Follow up was 54.2 months. Gradual correction was performed according to the individualized time schedule. We faced 42 difficulties: 29 problems, 10 obstacles and 3 complications, distributed across all years. Significant correlation was found between patient's age and number of difficulties. The incidence of the difficulties was equally spread over the different etiologies, but it was statistically significant across the years. Proximal tibia and complex multi-plane deformities seem to be related to an increased incidence of postoperative difficulties. TSF can yield accurate results, is easy to handle and provides an excellent concomitant 3-direction correction.

  9. Acquired midfoot deformity and function in individuals with diabetes and peripheral neuropathy

    PubMed Central

    Hastings, Mary K.; Mueller, Michael J.; Woodburn, James; Strube, Michael J; Commean, Paul; Johnson, Jeffrey E.; Cheuy, Victor; Sinacore, David R.

    2015-01-01

    Background Diabetes mellitus related medial column foot deformity is a major contributor to ulceration and amputation. However, little is known about the relationship between medial column alignment and function and the integrity of the soft tissues that support and move the medial column. The purposes of this study were to determine the predictors of medial column alignment and function in people with diabetes and peripheral neuropathy. Methods 23 participants with diabetes and neuropathy had radiographs, heel rise kinematics, magnetic resonance imaging and isokinetic muscle testing to measure: 1) medial column alignment (Meary’s angle- the angle between the 1st metatarsal longitudinal axis and the talar head and neck), 2) medial column function (forefoot relative to hindfoot plantarflexion during heel rise), 3) intrinsic foot muscle and fat volume, ratio of posterior tibialis to flexor digitorum tendon volume, 4) plantar fascia function (Meary’s angle change from toes flat to extended) and 5) plantarflexor peak torque. Predictors of medial column alignment and function were determined using simultaneous entry multiple regression. Findings Posterior tibialis to flexor digitorum tendon volume ratio and intrinsic foot muscle volume were significant predictors of medial column alignment (p<.05), accounting for 44% of the variance. Intrinsic foot fat volume and plantarflexor peak torque were significant predictors of medial column function (p<.05), accounting for 37% of the variance. Interpretation Deterioration of medial column supporting structures predicted alignment and function. Prospective research is required to monitor alignment, structure, and function over time to inform early intervention strategies to prevent deformity, ulceration, and amputation. PMID:26588885

  10. Prevalence of flatfoot in school between 3 and 10 years. Study of two different populations geographically and socially

    PubMed Central

    Serrano Sánchez, Rafael Fernando; Correa Posada, Juan Rafael; Molano, Adriana Carolina; Guevara, Oscar A

    2012-01-01

    Introduction: Children present with flatfoot from birth and it resolves along infancy. There have been several risk factors identified for the development of flatfoot: male sex, young age, overweight and obesity. The prevalence of flatfoot decreases with age. The aim of this study was to determine the prevalence of flatfoot in two different populations with different social, cultural and geographically characteristics in Colombia. Methods: This is a cross sectional study made on school children between 3 to 10 years of age, from several schools in Bogota and Barranquilla. From 940 total children 60% were from Bogota. Flatfoot was diagnosed according to physical exam. Results: We found a global prevalence of flatfoot of 15.7%, distributed 20.8% in Bogota and 7.9% in Barranquilla. The children from 3 to 5 years had a prevalence of 30.9%, decreasing significantly after this age. It was found that children 3 to 5 years old from Bogota had a prevalence of flatfoot of 38.3% while children from Barranquilla only 17.3%, decreasing significantly in children older than 6 years. In the multivariate analysis we found an association between flatfoot with age, city, gender and body mass index. Discussion: We found a bigger prevalence of flatfoot in the population of Bogota compared to Barranquilla suggesting an influence of social, cultural and racial factors in the development of flatfoot. The diminished prevalence of flatfoot in children over 6 years of age suggest that therapeutic measures before this age are not recommended. PMID:24893055

  11. Flatfoot Diagnosis by a Unique Bimodal Distribution of Footprint Index in Children

    PubMed Central

    Chang, Chia-Hsieh; Chen, Yu-Chen; Yang, Wen-Tien; Ho, Pei-Chi; Hwang, Ai-Wen; Chen, Chien-Hung; Chang, Jia-Hao; Chang, Liang-Wey

    2014-01-01

    Background More than 1000 scientific papers have been devoted to flatfoot issue. However, a bimodal distribution of flatfoot indices in school-aged children has never been discovered. The purposes of this study were to establish a new classification of flatfoot by characteristic in frequency distribution of footprint index and to endue the classification with discrepancy in physical fitness. Methods/Principal Findings In a longitudinal survey of physical fitness and body structure, weight bearing footprints and 3 physical fitness related tests were measured in 1228 school-aged children. Frequency distribution of initial data was tested by Kolmogorov-Smirnov test for normality and a unique bimodal distribution of footprint index was identified. The frequency distribution of footprint index manifests two distinct modes, flatfoot and non-flatfoot, by deconvolution and bootstrapping procedures. A constant intersection value of 1.0 in Staheli's arch index and 0.6 in Chippaux-Smirak index could distinguish the two modes of children, and the value was constant in different age, sex, and weight status. The performance of the one leg balance was inferior in flatfoot girls (median, 4.0 seconds in flatfoot girls vs. 4.3 seconds in non-flatfoot girls, p = 0.04, 95% CI 0.404–0.484). Discussion The natural bimodality lends itself to a flatfoot classification. Bimodality suggests development of the child's foot arch would be a leap from one state to another, rather than a continuous growth as body height and weight. The underlying dynamics of the human foot arch and motor development will trigger research prospects. PMID:25551228

  12. An investigation of the factors affecting flatfoot in children with delayed motor development.

    PubMed

    Chen, Kun-Chung; Tung, Li-Chen; Tung, Chien-Hung; Yeh, Chih-Jung; Yang, Jeng-Feng; Wang, Chun-Hou

    2014-03-01

    This study investigated the prevalence of flatfoot in children with delayed motor development and the relevant factors affecting it. In total, 121 preschool-aged children aged 3-6 with delayed motor development (male: 81; female: 40) were enrolled in the motor-developmentally delayed children group, and 4 times that number, a total of 484 children (male: 324; female: 160), of gender- and age-matched normal developmental children were used as a control group for further analyses. The age was from 3.0 to 6.9 years old for the participants. The judgment criterion of flatfoot was the Chippaux-Smirak index >62.70%, in footprint measurement. The results showed that the prevalence of flatfoot in children with motor developmental delay was higher than that in normal developmental children, approximately 58.7%, and that it decreased with age from 62.8% of 3-year-olds to 50.0% of 6-year-olds. The results also showed that motor-developmentally delayed children with flatfoot are at about 1.5 times the risk of normal developmental children (odds ratio=1.511, p=0.005). In addition, the prevalence of flatfoot is relatively higher in overweight children with delayed motor development, and that in obese children is even as high as 95.8% (23/24). Children with both excessive joint laxity and delayed development are more likely to suffer from flatfoot. The findings of this study can serve as a reference for clinical workers to deal with foot issues in children with delayed motor development.

  13. Comparison of Pediatric and General Orthopedic Surgeons’ Approaches in Management of Developmental Dysplasia of the Hip and Flexible Flatfoot: the Road to Clinical Consensus

    PubMed Central

    Zargarbashi, Ramin Haj; Bonaki, Hirbod Nasiri; Zadegan, Shayan Abdollah; Baghdadi, Taghi; Nabian, Mohammad Hossein; Shirazi, Mehdi Ramezan

    2017-01-01

    Developmental dysplasia of the hip (DDH) and flatfoot are common pediatric orthopedic disorders, being referred to and managed by both general and pediatric orthopedic surgeons, through various modalities. Our study aimed to evaluate their consensus and perspective disagreements in terms of diagnostic and therapeutic approaches of the mentioned deformities. Forty participants in two groups of general orthopedic surgeons (GOS) (n=20) and pediatric orthopedic surgeons (POS) (n=20), were asked to answer an 8-item questionnaire on DDH and flexible flatfoot. The questions were provided with two- or multiple choices and a single choice was accepted for each one. Chi-square and Fisher’s exact tests was performed to compare the responses. For a neonate with limited hip abduction, hip ultrasonography was the agreed-upon approach in both groups (100% POS vs 71% GOS), and for its interpretation 79% of POS relied on their own whereas 73% of GOS relied on radiologist’s report (P=0.002). In failure of a 3-week application of the Pavlik harness, ending it and closed reduction (57% POS vs. 41% GOS) followed by surgery quality assessment with CT scan (64% POS vs. 47% GOS) and without the necessity for avascular necrosis evaluation (79% POS vs. 73% GOS) were the choice measures. In case of closed reduction failure, open reduction via medial approach was the favorite next step in both groups (62% POS and 80% GOS). For the patient with flexible flat foot, reassurance was the choice plan of 79% of pediatric orthopedists. Our findings demonstrated significant disagreements among the orthopedic surgeons. This proposes insufficiency of high-level evidence. PMID:28271087

  14. Calcaneo-stop procedure in the treatment of the juvenile symptomatic flatfoot.

    PubMed

    Pavone, Vito; Costarella, Luciano; Testa, Gianluca; Conte, Giorgio; Riccioli, Maria; Sessa, Giuseppe

    2013-01-01

    Flexible flatfoot is the most prevalent condition seen in pediatric orthopedic clinics. It is characterized by an absence of the medial arch and a valgus position of the calcaneus. The purpose of the present study was to report on the results obtained in children treated using the calcaneo-stop procedure. A total of 410 flatfeet in 242 consecutive patients were treated using the calcaneo-stop procedure from January 1999 to March 2010 (10 years, 3 months) and were followed up to February 2012. The mean age at surgery was 11 (range 7 to 14) years, and the mean follow-up duration was 88 (range 14 to 157) months. A clinical evaluation, podoscopic examination, and radiologic assessment were performed in the participating patients preoperatively and at 6 months postoperatively. Of the 242 patients, 168 (69.42%) underwent bilateral foot surgery and 74 (30.58%) unilateral intervention, involving 33 right (44.6%) and 41 left (55.4%) feet. At follow-up, the outcome was satisfactory in 397 feet (96.83%); heel valgus was observed in only 12 feet (2.92%), and the footprint was normalized in 328 feet (80%). The calcaneo-stop procedure is a simple, reliable, and minimally invasive procedure for the treatment of pediatric flexible flatfoot. It allows alignment of the talus and calcaneus, restoring a proper foot arch.

  15. Validity of Footprint Analysis to Determine Flatfoot Using Clinical Diagnosis as the Gold Standard in a Random Sample Aged 40 Years and Older

    PubMed Central

    Pita-Fernández, Salvador; González-Martín, Cristina; Seoane-Pillado, Teresa; López-Calviño, Beatriz; Pértega-Díaz, Sonia; Gil-Guillén, Vicente

    2015-01-01

    Background Research is needed to determine the prevalence and variables associated with the diagnosis of flatfoot, and to evaluate the validity of three footprint analysis methods for diagnosing flatfoot, using clinical diagnosis as a benchmark. Methods We conducted a cross-sectional study of a population-based random sample ≥40 years old (n = 1002) in A Coruña, Spain. Anthropometric variables, Charlson’s comorbidity score, and podiatric examination (including measurement of Clarke’s angle, the Chippaux-Smirak index, and the Staheli index) were used for comparison with a clinical diagnosis method using a podoscope. Multivariate regression was performed. Informed patient consent and ethical review approval were obtained. Results Prevalence of flatfoot in the left and right footprint, measured using the podoscope, was 19.0% and 18.9%, respectively. Variables independently associated with flatfoot diagnosis were age (OR 1.07), female gender (OR 3.55) and BMI (OR 1.39). The area under the receiver operating characteristic curve (AUC) showed that Clarke’s angle is highly accurate in predicting flatfoot (AUC 0.94), followed by the Chippaux-Smirak (AUC 0.83) and Staheli (AUC 0.80) indices. Sensitivity values were 89.8% for Clarke’s angle, 94.2% for the Chippaux-Smirak index, and 81.8% for the Staheli index, with respective positive likelihood ratios or 9.7, 2.1, and 2.0. Conclusions Age, gender, and BMI were associated with a flatfoot diagnosis. The indices studied are suitable for diagnosing flatfoot in adults, especially Clarke’s angle, which is highly accurate for flatfoot diagnosis in this population. PMID:25382154

  16. Effects of wearing functional foot orthotic on pelvic angle among college students in their 20s with flatfoot

    PubMed Central

    Park, KwangYong

    2017-01-01

    [Purpose] This study examined the impact of wearing a functional foot orthotic on the pelvic angle of young adults who have flatfoot. [Subjects and Methods] A total of 15 college students diagnosed with flatfoot were included in the study. Changes in the pelvic angle in the stance period during walking before and after orthotic use were measured using a VICON Motion System (VICON, Hansung, Korea). The data were analyzed using SPSS 12.0 for Windows. [Results] In the experimental group, the pelvic angle during the mid-stance and mid-swing periods of the gait cycle significantly decreased on the left and right sides after wearing the orthotic, compared to the measurements taken before orthotic usage. The pelvic angle change on the left and right sides also decreased after wearing the orthotic, though this difference was not significant. [Conclusion] The pelvic angle of college students with flatfoot decreased after they wore orthotics. This implies that wearing orthotic shoes can greatly benefit individuals during normal walking by promoting passive changes that decrease the pelvic angle. PMID:28356626

  17. Flexible Flatfoot

    MedlinePlus

    ... foot and ankle surgeons. All Fellows of the College are board certified by the American Board of Foot and Ankle Surgery. Copyright © 2017 American College of Foot and Ankle Surgeons (ACFAS), All Rights ...

  18. Accessory Anterolateral Talar Facet as an Etiology of Painful Talocalcaneal Impingement in the Rigid Flatfoot: A New Diagnosis

    PubMed Central

    Martus, Jeffrey E.; Femino, John E.; Caird, Michelle S.; Kuhns, Lawrence R.; Craig, Clifford L.; Farley, Frances A.

    2008-01-01

    A retrospective review identified six patients with seven painful rigid flatfeet. In each case, pain was localized laterally to an accessory facet of the anterolateral talus. cross-sectional imaging demonstrated no evidence of tarsal coalition. In five of the six, preoperative magnetic resonance imaging (MRI) was obtained and in each case demonstrated focal abutting bone marrow edema consistent with impingement between the accessory facet and the anterior calcaneus. Seven feet in six patients underwent resection of the accessory facet with additional subtalar joint-sparing reconstructive procedures. At an average follow-up of 11 months, clinical results were graded as four good and two fair. An association between this accessory facet and pain in the rigid flatfoot has not been previously reported. Obesity was universal and may represent a risk factor for facet impingement. At early follow-up, facet resection with subtalar joint-sparing flatfoot reconstruction provided good results with symptomatic and functional improvement in the majority of patients. PMID:19223941

  19. Acquired hyperpigmentations*

    PubMed Central

    Cestari, Tania Ferreira; Dantas, Lia Pinheiro; Boza, Juliana Catucci

    2014-01-01

    Cutaneous hyperpigmentations are frequent complaints, motivating around 8.5% of all dermatological consultations in our country. They can be congenital, with different patterns of inheritance, or acquired in consequence of skin problems, systemic diseases or secondary to environmental factors. The vast majority of them are linked to alterations on the pigment melanin, induced by different mechanisms. This review will focus on the major acquired hyperpigmentations associated with increased melanin, reviewing their mechanisms of action and possible preventive measures. Particularly prominent aspects of diagnosis and therapy will be emphasized, with focus on melasma, post-inflammatory hyperpigmentation, periorbital pigmentation, dermatosis papulosa nigra, phytophotodermatoses, flagellate dermatosis, erythema dyschromicum perstans, cervical poikiloderma (Poikiloderma of Civatte), acanthosis nigricans, cutaneous amyloidosis and reticulated confluent dermatitis PMID:24626644

  20. The effects of short foot exercises and arch support insoles on improvement in the medial longitudinal arch and dynamic balance of flexible flatfoot patients

    PubMed Central

    Kim, Eun-Kyung; Kim, Jin Seop

    2016-01-01

    [Purpose] The purpose of the present study is to apply short foot exercises and arch support insoles in order to improve the medial longitudinal arch of flatfoot and compare the results to identify the effects of the foregoing exercises on the dynamic balance of the feet and the lower limbs. [Subjects and Methods] Fourteen university students with flexible flatfoot were selected by conducting navicular drop tests and randomly assigned to a short foot exercise group of seven subjects and an arch support insoles group of seven subjects. The intervention in the experiment was implemented for 30 minutes per time, three times per week for five weeks in total. [Results] In inter-group comparison conducted through navicular drop tests and Y-balance tests, the short foot exercise group showed significant differences. Among intra-group comparisons, in navicular drop tests, the short foot exercise group showed significant decreases. In Y-balance tests, both the short foot exercise group and the arch support insoles group showed significant increases. [Conclusion] In the present study, it could be seen that to improve flatfoot, applying short foot exercises was more effective than applying arch support insoles in terms of medial longitudinal arch improvement and dynamic balance ability. PMID:27942135

  1. Flowers of Cypripedium fargesii (Orchidaceae) fool flat-footed flies (Platypezidae) by faking fungus-infected foliage

    PubMed Central

    Ren, Zong-Xin; Li, De-Zhu; Bernhardt, Peter; Wang, Hong

    2011-01-01

    Charles Darwin was fascinated by the orchid–pollinator interactions, but he did not realize that many orchid species are pollinated by deceit. Cypripedium, a model lineage of nonrewarding orchid flowers, is pollinated primarily by bees. Here we present both an example of floral mimesis of fungus-infected foliage in orchids and an example of flat-footed flies (Agathomyia sp.; Platypezidae) as pollen vectors for angiosperms. Cypripedium fargesii is a nectarless, terrestrial, endangered orchid from southwestern China that requires cross-pollination to produce the maximum number of viable embryos. All insects caught entering or leaving the labellum sac were Agathomyia sp. carrying conidia of Cladosporium sp. on their mouthparts and legs, suggesting mycophagy. Blackish hairy spots on the upper surface of foliage may imitate black mold spots, serving as short-term visual lures. Some odor molecules also associated with Cladosporium cultures were isolated in the floral scent. Mimesis of fungus-infected foliage probably represents an overlooked but important option in angiosperm diversification, because there are three to five more Cypripedium spp. in southwestern China with the same mode of floral presentation and black-spotted hairy leaves. PMID:21502502

  2. Acquired Cystic Kidney Disease

    MedlinePlus

    ... They Work Kidney Disease A-Z Acquired Cystic Kidney Disease What is acquired cystic kidney disease? Acquired cystic kidney disease happens when a ... cysts. What are the differences between acquired cystic kidney disease and polycystic kidney disease? Acquired cystic kidney ...

  3. Spinal deformity.

    PubMed

    Bunnell, W P

    1986-12-01

    Spinal deformity is a relatively common disorder, particularly in teenage girls. Early detection is possible by a simple, quick visual inspection that should be a standard part of the routine examination of all preteen and teenage patients. Follow-up observation will reveal those curvatures that are progressive and permit orthotic treatment to prevent further increase in the deformity. Spinal fusion offers correction and stabilization of more severe degrees of scoliosis.

  4. Acquired Idiopathic Generalized Anhidrosis.

    PubMed

    Gangadharan, Geethu; Criton, Sebastian; Surendran, Divya

    2015-01-01

    Acquired idiopathic generalized anhidrosis is a rare condition, where the exact pathomechanism is unknown. We report a case of acquired idiopathic generalized anhidrosis in a patient who later developed lichen planus. Here an autoimmune-mediated destruction of sweat glands may be the probable pathomechanism.

  5. LABORATORY-ACQUIRED MYCOSES

    DTIC Science & Technology

    laboratory- acquired mycoses . Insofar as possible, the etiological fungus, type of laboratory, classification of personnel, type of work conducted, and other...pertinent data have been listed in this study. More than 288 laboratory- acquired mycoses are described here, including 108 cases of

  6. Acquired Upper Extremity Growth Arrest.

    PubMed

    Gauger, Erich M; Casnovsky, Lauren L; Gauger, Erica J; Bohn, Deborah C; Van Heest, Ann E

    2016-09-29

    This study reviewed the clinical history and management of acquired growth arrest in the upper extremity in pediatric patients. The records of all patients presenting from 1996 to 2012 with radiographically proven acquired growth arrest were reviewed. Records were examined to determine the etiology and site of growth arrest, management, and complications. Patients with tumors or hereditary etiology were excluded. A total of 44 patients (24 boys and 20 girls) with 51 physeal arrests who presented at a mean age of 10.6 years (range, 0.8-18.2 years) were included in the study. The distal radius was the most common site (n=24), followed by the distal humerus (n=8), metacarpal (n=6), distal ulna (n=5), proximal humerus (n=4), radial head (n=3), and olecranon (n=1). Growth arrest was secondary to trauma (n=22), infection (n=11), idiopathy (n=6), inflammation (n=2), compartment syndrome (n=2), and avascular necrosis (n=1). Twenty-six patients (59%) underwent surgical intervention to address deformity caused by the physeal arrest. Operative procedures included ipsilateral unaffected bone epiphysiodesis (n=21), shortening osteotomy (n=10), lengthening osteotomy (n=8), excision of physeal bar or bone fragment (n=2), angular correction osteotomy (n=1), and creation of single bone forearm (n=1). Four complications occurred; 3 of these required additional procedures. Acquired upper extremity growth arrest usually is caused by trauma or infection, and the most frequent site is the distal radius. Growth disturbances due to premature arrest can be treated effectively with epiphysiodesis or osteotomy. In this series, the specific site of anatomic growth arrest was the primary factor in determining treatment. [Orthopedics. 201x; xx(x):xx-xx.].

  7. Acquired inflammatory demyelinating neuropathies.

    PubMed

    Ensrud, E R; Krivickas, L S

    2001-05-01

    The acquired demyelinating neuropathies can be divided into those with an acute onset and course and those with a more chronic course. The acute neuropathies present as Guillain-Barré syndrome and include acute inflammatory demyelinating polyradiculoneuropathy (AIDP), Miller Fisher syndrome, acute motor axonal neuropathy (AMAN), acute motor and sensory axonal neuropathy (AMSAN), and acute pandysautonomia. The chronic neuropathies are collectively known as chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and include MADSAM (multifocal acquired demyelinating sensory and motor neuropathy, also know as Lewis-Sumner syndrome) and DADS (distal acquired demyelinating symmetric neuropathy) as variants. The clinical features, pathology, pathogenesis, diagnosis, treatment, rehabilitation, and prognosis of these neuropathies are discussed.

  8. Acquired color vision deficiency.

    PubMed

    Simunovic, Matthew P

    2016-01-01

    Acquired color vision deficiency occurs as the result of ocular, neurologic, or systemic disease. A wide array of conditions may affect color vision, ranging from diseases of the ocular media through to pathology of the visual cortex. Traditionally, acquired color vision deficiency is considered a separate entity from congenital color vision deficiency, although emerging clinical and molecular genetic data would suggest a degree of overlap. We review the pathophysiology of acquired color vision deficiency, the data on its prevalence, theories for the preponderance of acquired S-mechanism (or tritan) deficiency, and discuss tests of color vision. We also briefly review the types of color vision deficiencies encountered in ocular disease, with an emphasis placed on larger or more detailed clinical investigations.

  9. Acquired hypofibrinogenemia: current perspectives

    PubMed Central

    Besser, Martin W; MacDonald, Stephen G

    2016-01-01

    Acquired hypofibrinogenemia is most frequently caused by hemodilution and consumption of clotting factors. The aggressive replacement of fibrinogen has become one of the core principles of modern management of massive hemorrhage. The best method for determining the patient’s fibrinogen level remains controversial, and particularly in acquired dysfibrinogenemia, could have major therapeutic implications depending on which quantification method is chosen. This review introduces the available laboratory and point-of-care methods and discusses the relative advantages and limitations. It also discusses current strategies for the correction of hypofibrinogenemia. PMID:27713652

  10. Community-acquired pneumonia.

    PubMed

    Falguera, M; Ramírez, M F

    2015-11-01

    This article not only reviews the essential aspects of community-acquired pneumonia for daily clinical practice, but also highlights the controversial issues and provides the newest available information. Community-acquired pneumonia is considered in a broad sense, without excluding certain variants that, in recent years, a number of authors have managed to delineate, such as healthcare-associated pneumonia. The latter form is nothing more than the same disease that affects more frail patients, with a greater number of risk factors, both sharing an overall common approach.

  11. A two-dimensional deformable phantom for quantitatively verifying deformation algorithms

    SciTech Connect

    Kirby, Neil; Chuang, Cynthia; Pouliot, Jean

    2011-08-15

    Purpose: The incorporation of deformable image registration into the treatment planning process is rapidly advancing. For this reason, the methods used to verify the underlying deformation algorithms must evolve equally fast. This manuscript proposes a two-dimensional deformable phantom, which can objectively verify the accuracy of deformation algorithms, as the next step for improving these techniques. Methods: The phantom represents a single plane of the anatomy for a head and neck patient. Inflation of a balloon catheter inside the phantom simulates tumor growth. CT and camera images of the phantom are acquired before and after its deformation. Nonradiopaque markers reside on the surface of the deformable anatomy and are visible through an acrylic plate, which enables an optical camera to measure their positions; thus, establishing the ground-truth deformation. This measured deformation is directly compared to the predictions of deformation algorithms, using several similarity metrics. The ratio of the number of points with more than a 3 mm deformation error over the number that are deformed by more than 3 mm is used for an error metric to evaluate algorithm accuracy. Results: An optical method of characterizing deformation has been successfully demonstrated. For the tests of this method, the balloon catheter deforms 32 out of the 54 surface markers by more than 3 mm. Different deformation errors result from the different similarity metrics. The most accurate deformation predictions had an error of 75%. Conclusions: The results presented here demonstrate the utility of the phantom for objectively verifying deformation algorithms and determining which is the most accurate. They also indicate that the phantom would benefit from more electron density heterogeneity. The reduction of the deformable anatomy to a two-dimensional system allows for the use of nonradiopaque markers, which do not influence deformation algorithms. This is the fundamental advantage of this

  12. Acquired Brain Injury Program.

    ERIC Educational Resources Information Center

    Schwartz, Stacey Hunter

    This paper reviews the Acquired Brain Injury (ABI) Program at Coastline Community College (California). The ABI Program is a two-year, for-credit educational curriculum designed to provide structured cognitive retraining for adults who have sustained an ABI due to traumatic (such as motor vehicle accident or fall) or non-traumatic(such as…

  13. Hospital-acquired thrombocytopenia.

    PubMed

    McMahon, Christine M; Cuker, Adam

    2014-10-01

    The development of thrombocytopenia is common in hospitalized patients and is associated with increased mortality. Frequent and important causes of thrombocytopenia in hospitalized patients include etiologies related to the underlying illness for which the patient is admitted, such as infection and disseminated intravascular coagulation, and iatrogenic etiologies such as drug-induced immune thrombocytopenia, heparin-induced thrombocytopenia, posttransfusion purpura, hemodilution, major surgery, and extracorporeal circuitry. This review presents a brief discussion of the pathophysiology, distinguishing clinical features, and management of these etiologies, and provides a diagnostic approach to hospital-acquired thrombocytopenia that considers the timing and severity of the platelet count fall, the presence of hemorrhage or thrombosis, the clinical context, and the peripheral blood smear. This approach may offer guidance to clinicians in distinguishing among the various causes of hospital-acquired thrombocytopenia and providing management appropriate to the etiology.

  14. Desmosomes in acquired disease

    PubMed Central

    Stahley, Sara N.; Kowalczyk, Andrew P.

    2015-01-01

    Desmosomes are cell-cell junctions that mediate adhesion and couple the intermediate filament cytoskeleton to sites of cell-cell contact. This architectural arrangement functions to integrate adhesion and cytoskeletal elements of adjacent cells. The importance of this robust adhesion system is evident in numerous human diseases, both inherited and acquired, that occur when desmosome function is compromised. This review focuses on autoimmune and infectious diseases that impair desmosome function. In addition, we discuss emerging evidence that desmosomal genes are often misregulated in cancer. The emphasis of our discussion is placed on how human diseases inform our understanding of basic desmosome biology, and in turn, how fundamental advances in the cell biology of desmosomes may lead to new treatments for acquired diseases of the desmosome. PMID:25795143

  15. Desmosomes in acquired disease.

    PubMed

    Stahley, Sara N; Kowalczyk, Andrew P

    2015-06-01

    Desmosomes are cell-cell junctions that mediate adhesion and couple the intermediate filament cytoskeleton to sites of cell-cell contact. This architectural arrangement integrates adhesion and cytoskeletal elements of adjacent cells. The importance of this robust adhesion system is evident in numerous human diseases, both inherited and acquired, which occur when desmosome function is compromised. This review focuses on autoimmune and infectious diseases that impair desmosome function. In addition, we discuss emerging evidence that desmosomal genes are often misregulated in cancer. The emphasis of our discussion is placed on the way in which human diseases can inform our understanding of basic desmosome biology and in turn, the means by which fundamental advances in the cell biology of desmosomes might lead to new treatments for acquired diseases of the desmosome.

  16. Bunionette deformity.

    PubMed

    Cohen, Bruce E; Nicholson, Christopher W

    2007-05-01

    The bunionette, or tailor's bunion, is a lateral prominence of the fifth metatarsal head. Most commonly, bunionettes are the result of a widened 4-5 intermetatarsal angle with associated varus of the metatarsophalangeal joint. When symptomatic, these deformities often respond to nonsurgical treatment methods, such as wider shoes and padding techniques. When these methods are unsuccessful, surgical treatment is based on preoperative radiographs and associated lesions, such as hyperkeratoses. In rare situations, a simple lateral eminence resection is appropriate; however, the risk of recurrence or overresection is high with this technique. Patients with a lateral bow to the fifth metatarsal are treated with a distal chevron-type osteotomy. A widened 4-5 intermetatarsal angle often requires a diaphyseal osteotomy for correction.

  17. Acquired Factor V Inhibitor

    PubMed Central

    Hirai, Daisuke; Yamashita, Yugo; Masunaga, Nobutoyo; Katsura, Toshiaki; Akao, Masaharu; Okuno, Yoshiaki; Koyama, Hiroshi

    2016-01-01

    Inhibitors directed against factor V rarely occur, and the clinical symptoms vary. We herein report the case of a patient who presented with a decreased factor V activity that had decreased to <3 %. We administered vitamin K and 6 units of fresh frozen plasma, but she thereafter developed an intracerebral hemorrhage. It is unclear whether surgery >10 years earlier might have caused the development of a factor V inhibitor. The treatment of acquired factor V inhibitors is mainly the transfusion of platelet concentrates and corticosteroids. Both early detection and the early initiation of the treatment of factor V inhibitor are thus considered to be important. PMID:27746446

  18. Deformation measurements of smart aerodynamic surfaces

    NASA Astrophysics Data System (ADS)

    Fleming, Gary A.; Burner, Alpheus W.

    1999-10-01

    Video Model Deformation (VMD) and Projection Moire Interferometry (PMI) were used to acquire wind tunnel model deformation measurements of the Northrop Grumman-built Smart Wing tested in the NASA Langley Transonic Dynamics Tunnel. The F18-E/F platform Smart Wing was outfitted with embedded shape memory alloys to actuate a seamless trailing edge aileron and flat, and an embedded torque tube to generate wing twist. The VMD system was used to obtain highly accurate deformation measurements at three spanwise locations along the main body of the wing, and at spanwise locations on the flap and aileron. The PMI system was used to obtain full-field wing shape and deformation measurements over the entire wing lower surface. Although less accurate than the VMD system, the PMI system revealed deformations occurring between VMD target rows indistinguishable by VMD. This paper presents the VMD and PMI techniques and discusses their application in the Smart Wing test.

  19. Deformation Measurements of Smart Aerodynamic Surfaces

    NASA Technical Reports Server (NTRS)

    Fleming, Gary A.; Burner, Alpheus

    2005-01-01

    Video Model Deformation (VMD) and Projection Moire Interferometry (PMI) were used to acquire wind tunnel model deformation measurements of the Northrop Grumman-built Smart Wing tested in the NASA Langley Transonic Dynamics Tunnel. The F18-E/F planform Smart Wing was outfitted with embedded shape memory alloys to actuate a seamless trailing edge aileron and flap, and an embedded torque tube to generate wing twist. The VMD system was used to obtain highly accurate deformation measurements at three spanwise locations along the main body of the wing, and at spanwise locations on the flap and aileron. The PMI system was used to obtain full-field wing shape and deformation measurements over the entire wing lower surface. Although less accurate than the VMD system, the PMI system revealed deformations occurring between VMD target rows indistinguishable by VMD. This paper presents the VMD and PMI techniques and discusses their application in the Smart Wing test.

  20. [Acquired coagulant factor inhibitors].

    PubMed

    Nogami, Keiji

    2015-02-01

    Acquired coagulation factor inhibitors are an autoimmune disease causing bleeding symptoms due to decreases in the corresponding factor (s) which result from the appearance of autoantibodies against coagulation factors (inhibitor). This disease is quite different from congenital coagulation factor deficiencies based on genetic abnormalities. In recent years, cases with this disease have been increasing, and most have anti-factor VIII autoantibodies. The breakdown of the immune control mechanism is speculated to cause this disease since it is common in the elderly, but the pathology and pathogenesis are presently unclear. We herein describe the pathology and pathogenesis of factor VIII and factor V inhibitors. Characterization of these inhibitors leads to further analysis of the coagulation process and the activation mechanisms of clotting factors. In the future, with the development of new clotting examination method (s), we anticipate that further novel findings will be obtained in this field through inhibitor analysis. In addition, detailed elucidation of the coagulation inhibitory mechanism possibly leading to hemostatic treatment strategies for acquired coagulation factor disorders will be developed.

  1. Acquired epidermodysplasia verruciformis.

    PubMed

    Rogers, Heather D; Macgregor, Jennifer L; Nord, Kristin M; Tyring, Stephen; Rady, Peter; Engler, Danielle E; Grossman, Marc E

    2009-02-01

    Epidermodysplasia verruciformis (EV) is a rare autosomal recessive genodermatosis with an increased susceptibility to specific human papillomavirus (HPV) genotypes. Classically, this viral infection leads to the development of tinea versicolor-like macules on the trunk, neck, arms, and face during childhood, and over time, these lesions can progress to squamous cell carcinoma. More recently, an EV-like syndrome has been described in patients with impaired cell-mediated immunity. We describe two cases of EV-like syndrome in HIV-positive patients, review all previously reported cases of EV in patients with impaired cell-mediated immunity, introduce the term "acquired epidermodysplasia verruciformis" to describe EV developing in the immunocompromised host and examine the limited treatment options for these patients.

  2. AIDS: acquired immunodeficiency syndrome.

    PubMed Central

    Gilmore, N. J.; Beaulieu, R.; Steben, M.; Laverdière, M.

    1983-01-01

    Acquired immunodeficiency syndrome, or AIDS, is a new illness that occurs in previously healthy individuals. It is characterized by immunodeficiency, opportunistic infections and unusual malignant diseases. Life-threatening single or multiple infections with viruses, mycobacteria, fungi or protozoa are common. A rare neoplasm, Kaposi's sarcoma, has developed in approximately one third of patients with AIDS. More than 800 cases of AIDS have been reported in North America, over 24 of them in Canada. The majority of patients are male homosexuals, although AIDS has also developed in abusers of intravenously administered drugs, Haitian immigrants, individuals with hemophilia, recipients of blood transfusions, prostitutes, and infants, spouses and partners of patients with AIDS. The cause of AIDS is unknown, but the features are consistent with an infectious process. Early diagnosis can be difficult owing to the nonspecific symptoms and signs of the infections and malignant diseases. Therefore, vigilance by physicians is of utmost importance. PMID:6342737

  3. AIDS: acquired immunodeficiency syndrome *

    PubMed Central

    Gilmore, N.J.; Beaulieu, R.; Steben, M.; Laverdière, M.

    1992-01-01

    Acquired immunodeficiency syndrome, or AIDS, is a new illness that occurs in previously healthy individuals. It is characterized by immunodeficiency, opportunistic infections and unusual malignant diseases. Life-threatening single or multiple infections with viruses, mycobacteria, fungi or protozoa are common. A rare neoplasm, Kaposi's sarcoma, has developed in approximately one third of patients with AIDS. More than 800 cases of AIDS have been reported in North America, over 24 of them in Canada. The majority of patients are male homosexuals, although AIDS has also developed in abusers of intravenously administered drugs, Haitian immigrants, individuals with hemophilia, recipients of blood transfusions, prostitutes, and infants, spouses and partners of patients with AIDS. The cause of AIDS is unknown, but the features are consistent with an infectious process. Early diagnosis can be difficult owing to the nonspecific symptoms and signs of the infections and malignant diseases. Therefore, vigilance by physicians is of the utmost importance. PMID:1544049

  4. Forefoot supinatus.

    PubMed

    Evans, Erica L; Catanzariti, Alan R

    2014-07-01

    The supination of the forefoot that develops with adult acquired flatfoot is defined as forefoot supinatus. This deformity is an acquired soft tissue adaptation in which the forefoot is inverted on the rearfoot. Forefoot supinatus is a reducible deformity. Forefoot supinatus can mimic, and often be mistaken for, a forefoot varus. A forefoot varus differs from forefoot supinatus in that a forefoot varus is a congenital osseous deformity that induces subtalar joint pronation, whereas forefoot supinatus is acquired and develops because of subtalar joint pronation. This article discusses the acquired form of forefoot supinatus.

  5. Deformation mechanisms of antigorite serpentinite at subduction zone conditions determined from experimentally and naturally deformed rocks

    NASA Astrophysics Data System (ADS)

    Auzende, Anne-Line; Escartin, Javier; Walte, Nicolas P.; Guillot, Stéphane; Hirth, Greg; Frost, Daniel J.

    2015-02-01

    We performed deformation-DIA experiments on antigorite serpentinite at pressures of 1-3.5 GPa and temperatures of between 400 and 650 °C, bracketing the stability of antigorite under subduction zone conditions. For each set of pressure-temperature (P-T) conditions, we conducted two runs at strain rates of 5 ×10-5 and 1 ×10-4 s-1. We complemented our study with a sample deformed in a Griggs-type apparatus at 1 GPa and 400 °C (Chernak and Hirth, 2010), and with natural samples from Cuba and the Alps deformed under blueschist/eclogitic conditions. Optical and transmission electron microscopies were used for microstructural characterization and determination of deformation mechanisms. Our observations on experimentally deformed antigorite prior to breakdown show that deformation is dominated by cataclastic flow with observable but minor contribution of plastic deformation (microkinking and (001) gliding mainly expressed by stacking disorder mainly). In contrast, in naturally deformed samples, plastic deformation structures are dominant (stacking disorder, kinking, pressure solution), with minor but also perceptible contribution of brittle deformation. When dehydration occurs in experiments, plasticity increases and is coupled to local embrittlement that we attribute to antigorite dehydration. In dehydrating samples collected in the Alps, embrittlement is also observed suggesting that dehydration may contribute to intermediate-depth seismicity. Our results thus show that semibrittle deformation operates within and above the stability field of antigorite. However, the plastic deformation recorded by naturally deformed samples was likely acquired at low strain rates. We also document that the corrugated structure of antigorite controls the strain accommodation mechanisms under subduction conditions, with preferred inter- and intra-grain cracking along (001) and gliding along both a and b. We also show that antigorite rheology in subduction zones is partly controlled

  6. Acquired aplastic anemia.

    PubMed

    Keohane, Elaine M

    2004-01-01

    Acquired aplastic anemia (AA) is a disorder characterized by a profound deficit of hematopoietic stem and progenitor cells, bone marrow hypocellularity, and peripheral blood pancytopenia. It primarily affects children, young adults, and those over 60 years of age. The majority of cases are idiopathic; however, idiosyncratic reactions to some drugs, chemicals, and viruses have been implicated in its etiology. An autoimmune T-cell reaction likely causes the stem cell depletion, but the precise mechanism, as well as the eliciting and target antigens, is unknown. Symptoms vary from severe life-threatening cytopenias to moderate or non-severe disease that does not require transfusion support. The peripheral blood typically exhibits pancytopenia, reticulocytopenia, and normocytic or macrocytic erythrocytes. The bone marrow is hypocellular and may exhibit dysplasia of the erythrocyte precursors. First line treatment for severe AA consists of hematopoietic stem cell transplantation in young patients with HLA identical siblings, while immunosuppression therapy is used for older patients and for those of any age who lack a HLA matched donor. Patients with AA have an increased risk of developing paroxysmal nocturnal hemoglobinuria (PNH), myelodysplastic syndrome (MDS), or acute leukemia. Further elucidation of the pathophysiology of this disease will result in a better understanding of the interrelationship among AA, PNH, and MDS, and may lead to novel targeted therapies.

  7. Acquired spatial dyslexia.

    PubMed

    Siéroff, E

    2015-08-10

    Acquired spatial dyslexia is a reading disorder frequently occurring after left or right posterior brain lesions. This article describes several types of spatial dyslexia with an attentional approach. After right posterior lesions, patients show left neglect dyslexia with errors on the left side of text, words, and non-words. The deficit is frequently associated with left unilateral spatial neglect. Severe left neglect dyslexia can be detected with unlimited exposure duration of words or non-words. Minor neglect dyslexia is detected with brief presentation of bilateral words, one in the left and one in the right visual field (phenomenon of contralesional extinction). Neglect dyslexia can be explained as a difficulty in orienting attention to the left side of verbal stimuli. With left posterior lesions, spatial dyslexia is also frequent but multiform. Right neglect dyslexia is frequent, but right unilateral spatial neglect is rare. Attentional dyslexia represents difficulty in selecting a stimulus, letter or word among other similar stimuli; it is a deficit of attentional selection, and the left hemisphere plays a crucial role in selection. Two other types of spatial dyslexia can be found after left posterior lesions: paradoxical ipsilesional extinction and stimulus-centred neglect dyslexia. Disconnections between left or right parietal attentional areas and the left temporal visual word form area could explain these deficits. Overall, a model of attention dissociating modulation, selection control, and selection positioning can help in understanding these reading disorders.

  8. ACQUIRED PES CAVUS IN CHARCOT-MARIE-TOOTH DISEASE.

    PubMed

    Carvalho Maranho, Daniel Augusto; Volpon, José Batista

    2009-01-01

    Hereditary motor and sensory neuropathies, especially Charcot-Marie-Tooth disease, are frequently expressed with an acquired cavusvarus foot which is characterized by a fixed increase of the plantar arch and hindfoot inversion. Diagnosis of the underlying condition achieved through careful patient assessment and local evaluations is the keystone for decision-making about the adequate treatment. The cavus may present as an isolated deformity of the forefoot, hindfoot or it may be a combination of both locations. Related deformities, mainly the varus and toe clawing require appropriate evaluation; clinical characteristics such as severity of the deformity, impairment of the muscular power, flexibility and patient's age are important characteristics in the treatment decision. Conservative treatment of the cavusvarus foot with physiotherapy, insoles and shoe modifications are reserved to young patients and mild deformities. However, there is a tendency of the deformity to become more severe over time because of the progressive feature of the underlying neurological condition. So, the surgical treatment by using classical techniques is performed in early stages. Most importantly is the identification of the primary and main components of each deformity to properly correct them, if possible. Muscular transfers are used to treat the dynamic unbalance, retracted structures should be either divided or lengthened and localized osteotomies should be preferred over arthrodeses, which are reserved for stiff and severely deformed feet in adults.

  9. ACQUIRED PES CAVUS IN CHARCOT-MARIE-TOOTH DISEASE

    PubMed Central

    Carvalho Maranho, Daniel Augusto; Volpon, José Batista

    2015-01-01

    Hereditary motor and sensory neuropathies, especially Charcot-Marie-Tooth disease, are frequently expressed with an acquired cavusvarus foot which is characterized by a fixed increase of the plantar arch and hindfoot inversion. Diagnosis of the underlying condition achieved through careful patient assessment and local evaluations is the keystone for decision-making about the adequate treatment. The cavus may present as an isolated deformity of the forefoot, hindfoot or it may be a combination of both locations. Related deformities, mainly the varus and toe clawing require appropriate evaluation; clinical characteristics such as severity of the deformity, impairment of the muscular power, flexibility and patient's age are important characteristics in the treatment decision. Conservative treatment of the cavusvarus foot with physiotherapy, insoles and shoe modifications are reserved to young patients and mild deformities. However, there is a tendency of the deformity to become more severe over time because of the progressive feature of the underlying neurological condition. So, the surgical treatment by using classical techniques is performed in early stages. Most importantly is the identification of the primary and main components of each deformity to properly correct them, if possible. Muscular transfers are used to treat the dynamic unbalance, retracted structures should be either divided or lengthened and localized osteotomies should be preferred over arthrodeses, which are reserved for stiff and severely deformed feet in adults. PMID:27077056

  10. Acquired reactive perforating collagenosis

    PubMed Central

    Fei, Chengwen; Wang, Yao; Gong, Yu; Xu, Hui; Yu, Qian; Shi, Yuling

    2016-01-01

    Abstract Background: Reactive perforating collagenosis (RPC) is a rare form of transepithelial elimination, in which altered collagen is extruded through the epidermis. There are 2 types of RPC, acquired RPC (ARPC) and inherited RPC, while the latter is extremely rare. Here we report on 1 case of ARPC. Methods: A 73-year-old female was presented with strongly itchy papules over her back and lower limbs for 3 months. She denied the history of oozing or vesiculation. A cutaneous examination showed diffusely distributed multiple well-defined keratotic papules, 4 to 10 mm in diameter, on the bilateral lower limbs and back as well as a few papules on her chest and forearm. Scratching scars were over the resolved lesions while Koebner phenomenon was negative. The patient had a history of type 2 diabetes for 15 years. Laboratory examinations showed elevated blood glucose level. Skin lesion biopsy showed a well-circumscribed area of necrosis filled with a keratotic plug. Parakeratotic cells and lymphocytic infiltration could be seen in the necrosed area. In dermis, sparse fiber bundles were seen perforating the epidermis. These degenerated fiber bundles were notarized as collagen fiber by elastic fiber stain, suggesting a diagnosis of RPC. Results: Then a diagnosis of ARPC was made according to the onset age and the history of diabetes mellitus. She was treated with topical application of corticosteroids twice a day and oral antihistamine once a day along with compound glycyrrhizin tablets 3 times a day. And the blood glucose was controlled in a satisfying range. Two months later, a significant improvement was seen in this patient. Conclusion: Since there is no efficient therapy to RPC, moreover, ARPC is considered to be associated with some systemic diseases, the management of the coexisting disease is quite crucial. The patient in this case received a substantial improvement due to the control of blood glucose and application of compound glycyrrhizin tablets. PMID

  11. 16 CFR 801.2 - Acquiring and acquired persons.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Acquiring and acquired persons. 801.2 Section 801.2 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 COVERAGE RULES § 801.2...

  12. 16 CFR 801.2 - Acquiring and acquired persons.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Acquiring and acquired persons. 801.2 Section 801.2 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 COVERAGE RULES § 801.2...

  13. 16 CFR 801.2 - Acquiring and acquired persons.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Acquiring and acquired persons. 801.2 Section 801.2 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 COVERAGE RULES § 801.2...

  14. 16 CFR 801.2 - Acquiring and acquired persons.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Acquiring and acquired persons. 801.2 Section 801.2 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 COVERAGE RULES § 801.2...

  15. 16 CFR 801.2 - Acquiring and acquired persons.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Acquiring and acquired persons. 801.2 Section 801.2 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 COVERAGE RULES § 801.2...

  16. Acquired dorsal intraspinal epidermoid cyst in an adult female

    PubMed Central

    Singh, Kulwant; Pandey, Sharad; Gupta, Praveen Kumar; Sharma, Vivek; Santhosh, Deepa; Ghosh, Amrita

    2016-01-01

    Background: Epidermoid and dermoid cyst comprise <1% of spinal tumors and may be congenital (hamartoma) or acquired (iatrogenic) in origin. Epidermoid cysts within the neuraxis are rare benign neoplasms that are most commonly located in the intracranial region. Case Description: Here, we report the a case of an acquired intradural extramedullary epidermoid cyst involving the thoracic region in an adult female who had no associated history of an accompanying congenital spinal deformity. Conclusion: Early diagnosis and immediate surgical intervention reduce patient morbidity. Near complete or subtotal excision of the cyst wall is warranted to prevent inadvertent injury to the spinal cord thus minimizing neurological morbidity. PMID:26904369

  17. Congenital and acquired orthopedic abnormalities in patients with myelomeningocele.

    PubMed

    Westcott, M A; Dynes, M C; Remer, E M; Donaldson, J S; Dias, L S

    1992-11-01

    This article presents a radiologic review of the spectrum of acquired and congenital orthopedic abnormalities found in patients with myelomeningocele. These abnormalities are caused predominantly by muscle imbalance, paralysis, and decreased sensation in the lower extremity. Iatrogenic injury, such as a postoperative tethered cord, may also cause bone abnormalities. Selected images were obtained from more than 800 children. Important entities presented include spinal curvatures such as kyphosis, scoliosis, and lordosis; subluxation and dislocation of the hip, coxa valga, contractures of the hip, and femoral torsion; knee deformities; rotational abnormalities of the lower extremity and external and internal torsion; ankle and foot abnormalities such as ankle valgus, calcaneus foot, congenital vertical talus (rocker-bottom deformity), and talipes equinovarus; and metaphyseal, diaphyseal, and physeal fractures. Familiarity with congenital abnormalities and an understanding of the pathogenesis of acquired disorders in patients with myelomeningocele are essential for proper radiologic interpretation and timely therapy.

  18. SU-E-J-104: Evaluation of Accuracy for Various Deformable Image Registrations with Virtual Deformation QA Software

    SciTech Connect

    Han, S; Kim, K; Kim, M; Jung, H; Ji, Y; Choi, S; Park, S

    2015-06-15

    Purpose: The accuracy of deformable image registration (DIR) has a significant dosimetric impact in radiation treatment planning. We evaluated accuracy of various DIR algorithms using virtual deformation QA software (ImSimQA, Oncology System Limited, UK). Methods: The reference image (Iref) and volume (Vref) was first generated with IMSIMQA software. We deformed Iref with axial movement of deformation point and Vref depending on the type of deformation that are the deformation1 is to increase the Vref (relaxation) and the deformation 2 is to decrease the Vref (contraction) .The deformed image (Idef) and volume (Vdef) were inversely deformed to Iref and Vref using DIR algorithms. As a Result, we acquired deformed image (Iid) and volume (Vid). The DIR algorithms were optical flow (HS, IOF) and demons (MD, FD) of the DIRART. The image similarity evaluation between Iref and Iid was calculated by Normalized Mutual Information (NMI) and Normalized Cross Correlation (NCC). The value of Dice Similarity Coefficient (DSC) was used for evaluation of volume similarity. Results: When moving distance of deformation point was 4 mm, the value of NMI was above 1.81 and NCC was above 0.99 in all DIR algorithms. Since the degree of deformation was increased, the degree of image similarity was decreased. When the Vref increased or decreased about 12%, the difference between Vref and Vid was within ±5% regardless of the type of deformation. The value of DSC was above 0.95 in deformation1 except for the MD algorithm. In case of deformation 2, that of DSC was above 0.95 in all DIR algorithms. Conclusion: The Idef and Vdef have not been completely restored to Iref and Vref and the accuracy of DIR algorithms was different depending on the degree of deformation. Hence, the performance of DIR algorithms should be verified for the desired applications.

  19. Deformations in VLBI antennas

    NASA Technical Reports Server (NTRS)

    Clark, T. A.; Thomsen, P.

    1988-01-01

    A study is presented of deformations in antennas with the emphasis on their influence on VLBI measurements. The GIFTS structural analysis program has been used to model the VLBI antenna in Fairbanks (Alaska). The report identifies key deformations and studies the effect of gravity, wind, and temperature. Estimates of expected deformations are given.

  20. Deformations of superconformal theories

    NASA Astrophysics Data System (ADS)

    Córdova, Clay; Dumitrescu, Thomas T.; Intriligator, Kenneth

    2016-11-01

    We classify possible supersymmetry-preserving relevant, marginal, and irrelevant deformations of unitary superconformal theories in d ≥ 3 dimensions. Our method only relies on symmetries and unitarity. Hence, the results are model independent and do not require a Lagrangian description. Two unifying themes emerge: first, many theories admit deformations that reside in multiplets together with conserved currents. Such deformations can lead to modifications of the supersymmetry algebra by central and non-central charges. Second, many theories with a sufficient amount of supersymmetry do not admit relevant or marginal deformations, and some admit neither. The classification is complicated by the fact that short superconformal multiplets display a rich variety of sporadic phenomena, including supersymmetric deformations that reside in the middle of a multiplet. We illustrate our results with examples in diverse dimensions. In particular, we explain how the classification of irrelevant supersymmetric deformations can be used to derive known and new constraints on moduli-space effective actions.

  1. Musicality: instinct or acquired skill?

    PubMed

    Marcus, Gary F

    2012-10-01

    Is the human tendency toward musicality better thought of as the product of a specific, evolved instinct or an acquired skill? Developmental and evolutionary arguments are considered, along with issues of domain-specificity. The article also considers the question of why humans might be consistently and intensely drawn to music if musicality is not in fact the product of a specifically evolved instinct.

  2. Duplicated Information Acquired by Libraries.

    ERIC Educational Resources Information Center

    White, Carl M.

    The object of this study is to make a start toward determining the extent of duplicated information that is being acquired in spite of customary precautions to avoid it. Referring to a specific case, the percentages in Table II show the frequency of appearance in five other works of 19 items in Mitchell's "Encyclopedia of American Politics." While…

  3. Acquired aplastic anemia in children.

    PubMed

    Hartung, Helge D; Olson, Timothy S; Bessler, Monica

    2013-12-01

    This article provides a practice-based and concise review of the etiology, diagnosis, and management of acquired aplastic anemia in children. Bone marrow transplantation, immunosuppressive therapy, and supportive care are discussed in detail. The aim is to provide the clinician with a better understanding of the disease and to offer guidelines for the management of children with this uncommon yet serious disorder.

  4. Measurement of Rotorcraft Blade Deformation using Projection Moire Interferometry

    NASA Technical Reports Server (NTRS)

    Fleming, Gary A.; Gorton, Susan Althoff

    1998-01-01

    Projection Moire Interferometry (PMI) has been used to obtain near instantaneous, quantitative blade deformation measurements of a generic rotorcraft model at several test conditions. These laser-based measurements provide quantitative, whole field, dynamic blade deformation profiles conditionally sampled as a function of rotor azimuth. The instantaneous nature of the measurements permits computation of the mean and unsteady blade deformation, blade bending, and twist. The PMI method is presented, and the image processing steps required to obtain quantitative deformation profiles from PMI interferograms are described. Experimental results are provided which show blade bending, twist, and unsteady motion. This initial proof-of-concept test has demonstrated the capability of PMI to acquire accurate, full field rotorcraft blade deformation data.

  5. Deformation mechanisms in experimentally deformed Boom Clay

    NASA Astrophysics Data System (ADS)

    Desbois, Guillaume; Schuck, Bernhard; Urai, Janos

    2016-04-01

    Bulk mechanical and transport properties of reference claystones for deep disposal of radioactive waste have been investigated since many years but little is known about microscale deformation mechanisms because accessing the relevant microstructure in these soft, very fine-grained, low permeable and low porous materials remains difficult. Recent development of ion beam polishing methods to prepare high quality damage free surfaces for scanning electron microscope (SEM) is opening new fields of microstructural investigation in claystones towards a better understanding of the deformation behavior transitional between rocks and soils. We present results of Boom Clay deformed in a triaxial cell in a consolidated - undrained test at a confining pressure of 0.375 MPa (i.e. close to natural value), with σ1 perpendicular to the bedding. Experiments stopped at 20 % strain. As a first approximation, the plasticity of the sample can be described by a Mohr-Coulomb type failure envelope with a coefficient of cohesion C = 0.117 MPa and an internal friction angle ϕ = 18.7°. After deformation test, the bulk sample shows a shear zone at an angle of about 35° from the vertical with an offset of about 5 mm. We used the "Lamipeel" method that allows producing a permanent absolutely plane and large size etched micro relief-replica in order to localize and to document the shear zone at the scale of the deformed core. High-resolution imaging of microstructures was mostly done by using the BIB-SEM method on key-regions identified after the "Lamipeel" method. Detailed BIB-SEM investigations of shear zones show the following: the boundaries between the shear zone and the host rock are sharp, clay aggregates and clastic grains are strongly reoriented parallel to the shear direction, and the porosity is significantly reduced in the shear zone and the grain size is smaller in the shear zone than in the host rock but there is no evidence for broken grains. Comparison of microstructures

  6. Acquired thoracic scoliosis following minimally invasive repair of pectus excavatum.

    PubMed

    Niedbala, Angela; Adams, Michael; Boswell, William C; Considine, John M

    2003-06-01

    The minimally invasive pectus excavatum repair as described by Nuss et al. is rapidly gaining acceptance as an effective method of repair of severe pectus excavatum deformities in the pediatric population. It potentially offers several advantages over previous techniques. The incidence of major complications of the procedure has been reduced by recent modifications including utilization of video-assisted thoracoscopy during placement of the Lorenz pectus bar as well as utilizing the pectus bar stabilizer that provides more rigid fixation of the strut. We report two cases of acquired thoracic scoliosis following minimally invasive repair of severe pectus excavatum deformity. This particular complication has not been reported in previous literature and warrants concern. In both cases the thoracic scoliosis slowly improved with physical therapy and range-of-motion exercises.

  7. Nursing home-acquired pneumonia.

    PubMed

    El Solh, Ali A

    2009-02-01

    Nursing home-acquired pneumonia (NHAP) was first described in 1978. Since then there has been much written regarding NHAP and its management despite the lack of well-designed studies in this patient population. The most characteristic features of patients with NHAP are the atypical presentation, which may lead to delay in diagnosis and therapy. The microbial etiology of pneumonia encompasses a wide spectrum that spans microbes recovered from patients with community-acquired pneumonia to organisms considered specific only to nosocomial settings. Decision to transfer a nursing home patient to an acute care facility depends on a host of factors, which include the level of staffing available at the nursing home, patients' advance directives, and complexity of treatment. The presence of risk factors for multidrug-resistant pathogens dictates approach to therapy. Prevention remains the cornerstone of reducing the incidence of disease. Despite the advance in medical services, mortality from NHAP remains high.

  8. Occupationally Acquired American Cutaneous Leishmaniasis

    PubMed Central

    Felinto de Brito, Maria Edileuza; Andrade, Maria Sandra; de Almeida, Éricka Lima; Medeiros, Ângela Cristina Rapela; Werkhäuser, Roberto Pereira; de Araújo, Ana Isabele Freitas; Brandão-Filho, Sinval Pinto; Paiva de Almeida, Alzira Maria; Gomes Rodrigues, Eduardo Henrique

    2012-01-01

    We report two occupationally acquired cases of American cutaneous leishmaniasis (ACL): one accidental laboratory autoinoculation by contaminated needlestick while handling an ACL lesion sample, and one acquired during field studies on bird biology. Polymerase chain reaction (PCR) assays of patient lesions were positive for Leishmania, subgenus Viannia. One isolate was obtained by culture (from patient 2 biopsy samples) and characterized as Leishmania (Viannia) naiffi through an indirect immunofluorescence assay (IFA) with species-specific monoclonal antibodies (mAbs) and by multilocus enzyme electrophoresis (MLEE). Patients were successfully treated with N-methyl-glucamine. These two cases highlight the potential risks of laboratory and field work and the need to comply with strict biosafety procedures in daily routines. The swab collection method, coupled with PCR detection, has greatly improved ACL laboratory diagnosis. PMID:23227369

  9. [Acquired disorders of color vision].

    PubMed

    Lascu, Lidia; Balaş, Mihaela

    2002-01-01

    This article is a general view of acquired disorders of color vision. The revision of the best known methods and of the etiopathogenic classification is not very important in ophthalmology but on the other hand, the detection of the blue defect advertise and associated ocular pathology. There is a major interest in serious diseases as multiple sclerosis, AIDS, diabetes melitus, when the first ocular sign can be a defect in the color vision.

  10. Calcaneo-valgus deformity.

    PubMed

    Evans, D

    1975-08-01

    A discussion of the essential deformity in calcaneo-valgus feet develops a theme originally put forward in 1961 on the relapsed club foot (Evans 1961). Whereas in the normal foot the medial and lateral columns are about equal in length, in talipes equino-varus the lateral column is longer and in calcaneo-valgus shorter than the medial column. The suggestion is that in the treatment of both deformities the length of the columns be made equal. A method is described of treating calcaneo-valgus deformity by inserting cortical bone grafts taken from the tibia to elongate the anterior end of the calcaneus.

  11. Rock Deformation Meeting

    NASA Astrophysics Data System (ADS)

    Green, Harry

    The Third Rock Deformation Colloquium was held December 4, 1989, at the AGU Fall Meeting in San Francisco. Steve Kirby of the U.S. Geological Survey, Menlo Park, Calif., reported on actions taken by the rock deformation steering committee. Brian Wernicke of Harvard University, Cambridge, Mass., talked on the structural geology of the Great Basin.The steering committee voted for “Committee on Deformation of Earth Materials” as the name for the AGU technical committee on rock deformation, Kirby said. Considerable discussion has occurred in the steering committee over our relationship to the AGU Mineral Physics Committee. Indeed, Kirby will become chairman of that committee in 1990, underlining the overlap of the two groups. It was agreed that we will pursue closer association with Mineral Physics.

  12. Wrist deformities after fracture.

    PubMed

    Vanheest, Ann

    2006-02-01

    Wrist deformities can occur after fracture because of malunion of the fracture or injury to the growth plate leading to imbalance of growth. Prevention of malunion is paramount by early recognition with proper reduction and casting or fixation with casting. If a mal-union occurs, an osteotomy may be necessary if anticipated growth will not correct the deformity. Injury of the growth plate may lead to wrist deformity in two ways: angular growth or growth arrest. Angular growth deformities are corrected most commonly by osteotomy. Growth arrest of the radius or the ulna leads to an ulnar-positive or an ulnar-negative variance at the wrist. If the ulnar variance is symptomatic, treatment is centered on achieving a level joint. Options for joint leveling procedures include epiphysiodesis or physeal stapling of the longer bone, lengthening osteotomy of the shorter bone, or shortening osteotomy of the longer bone.

  13. The inhibition of acquired fear.

    PubMed

    Izquierdo, Iván; Cammarota, Martín; Vianna, Mónica M R; Bevilaqua, Lía R M

    2004-01-01

    A conditioned stimulus (CS) associated with a fearsome unconditioned stimulus (US) generates learned fear. Acquired fear is at the root of a variety of mental disorders, among which phobias, generalized anxiety, the posttraumatic stress disorder (PTSD) and some forms of depression. The simplest way to inhibit learned fear is to extinguish it, which is usually done by repeatedly presenting the CS alone, so that a new association, CS-"no US", will eventually overcome the previously acquired CS-US association. Extinction was first described by Pavlov as a form of "internal inhibition" and was recommended by Freud and Ferenczi in the 1920s (who called it "habituation") as the treatment of choice for phobic disorders. It is used with success till this day, often in association with anxiolytic drugs. Extinction has since then been applied, also successfully and also often in association with anxiolytics, to the treatment of panic, generalized anxiety disorders and, more recently, PTSD. Extinction of learned fear involves gene expression, protein synthesis, N-methyl-D-aspartate (NMDA) receptors and signaling pathways in the hippocampus and the amygdala at the time of the first CS-no US association. It can be enhanced by increasing the exposure to the "no US" component at the time of behavioral testing, to the point of causing the complete uninstallment of the original fear response. Some theorists have recently proposed that reiteration of the CS alone may induce a reconsolidation of the learned behavior instead of its extinction. Reconsolidation would preserve the original memory from the labilization induced by its retrieval. If true, this would of course be disastrous for the psychotherapy of fear-motivated disorders. Here we show that neither the CS nor retrieval cause anything remotely like reconsolidation, but just extinction. In fact, our findings indicate that the reconsolidation hypothesis is essentially incorrect, at least for the form of contextual fear most

  14. Principles of rock deformation

    SciTech Connect

    Nicolas, A.

    1987-01-01

    This text focuses on the recent achievements in the analysis of rock deformation. It gives an analytical presentation of the essential structures in terms of kinetic and dynamic interpretation. The physical properties underlying the interpretation of rock structures are exposed in simple terms. Emphasized in the book are: the role of fluids in rock fracturing; the kinematic analysis of magnetic flow structures; the application of crystalline plasticity to the kinematic and dynamic analysis of the large deformation imprinted in many metamorphic rocks.

  15. Tidal deformations of a spinning compact object

    NASA Astrophysics Data System (ADS)

    Pani, Paolo; Gualtieri, Leonardo; Maselli, Andrea; Ferrari, Valeria

    2015-07-01

    The deformability of a compact object induced by a perturbing tidal field is encoded in the tidal Love numbers, which depend sensibly on the object's internal structure. These numbers are known only for static, spherically-symmetric objects. As a first step to compute the tidal Love numbers of a spinning compact star, here we extend powerful perturbative techniques to compute the exterior geometry of a spinning object distorted by an axisymmetric tidal field to second order in the angular momentum. The spin of the object introduces couplings between electric and magnetic deformations and new classes of induced Love numbers emerge. For example, a spinning object immersed in a quadrupolar, electric tidal field can acquire some induced mass, spin, quadrupole, octupole and hexadecapole moments to second order in the spin. The deformations are encoded in a set of inhomogeneous differential equations which, remarkably, can be solved analytically in vacuum. We discuss certain subtleties in defining the tidal Love numbers in general relativity, which are due to the difficulty in separating the tidal field from the linear response of the object in the solution, even in the static case. By extending the standard procedure to identify the linear response in the static case, we prove analytically that the Love numbers of a Kerr black hole remain zero to second order in the spin. As a by-product, we provide the explicit form for a slowly-rotating, tidally-deformed Kerr black hole to quadratic order in the spin, and discuss its geodesic and geometrical properties.

  16. A microfluidic technique to probe cell deformability.

    PubMed

    Hoelzle, David J; Varghese, Bino A; Chan, Clara K; Rowat, Amy C

    2014-09-03

    Here we detail the design, fabrication, and use of a microfluidic device to evaluate the deformability of a large number of individual cells in an efficient manner. Typically, data for ~10(2) cells can be acquired within a 1 hr experiment. An automated image analysis program enables efficient post-experiment analysis of image data, enabling processing to be complete within a few hours. Our device geometry is unique in that cells must deform through a series of micron-scale constrictions, thereby enabling the initial deformation and time-dependent relaxation of individual cells to be assayed. The applicability of this method to human promyelocytic leukemia (HL-60) cells is demonstrated. Driving cells to deform through micron-scale constrictions using pressure-driven flow, we observe that human promyelocytic (HL-60) cells momentarily occlude the first constriction for a median time of 9.3 msec before passaging more quickly through the subsequent constrictions with a median transit time of 4.0 msec per constriction. By contrast, all-trans retinoic acid-treated (neutrophil-type) HL-60 cells occlude the first constriction for only 4.3 msec before passaging through the subsequent constrictions with a median transit time of 3.3 msec. This method can provide insight into the viscoelastic nature of cells, and ultimately reveal the molecular origins of this behavior.

  17. Polygonal deformation bands

    NASA Astrophysics Data System (ADS)

    Antonellini, Marco; Mollema, Pauline Nella

    2015-12-01

    We report for the first time the occurrence of polygonal faults in sandstone, which is compelling given that layer-bound polygonal fault systems have been observed so far only in fine-grained sediments such as clay and chalk. The polygonal faults are shear deformation bands that developed under shallow burial conditions via strain hardening in dm-wide zones. The edges of the polygons are 1-5 m long. The shear deformation bands are organized as conjugate faults along each edge of the polygon and form characteristic horst-like structures. The individual deformation bands have slip magnitudes ranging from a few mm to 1.5 cm; the cumulative average slip magnitude in a zone is up to 10 cm. The deformation bands heaves, in aggregate form, accommodate a small isotropic horizontal extension (strain <0.005). The individual shear deformation bands show abutting T-junctions, veering, curving, and merging where they mechanically interact. Crosscutting relationships are rare. The interactions of the deformation bands are similar to those of mode I opening fractures. The documented fault networks have important implications for evaluating the geometry of km-scale polygonal fault systems in the subsurface, top seal integrity, as well as constraining paleo-tectonic stress regimes.

  18. Deformable Medical Image Registration: A Survey

    PubMed Central

    Sotiras, Aristeidis; Davatzikos, Christos; Paragios, Nikos

    2013-01-01

    Deformable image registration is a fundamental task in medical image processing. Among its most important applications, one may cite: i) multi-modality fusion, where information acquired by different imaging devices or protocols is fused to facilitate diagnosis and treatment planning; ii) longitudinal studies, where temporal structural or anatomical changes are investigated; and iii) population modeling and statistical atlases used to study normal anatomical variability. In this paper, we attempt to give an overview of deformable registration methods, putting emphasis on the most recent advances in the domain. Additional emphasis has been given to techniques applied to medical images. In order to study image registration methods in depth, their main components are identified and studied independently. The most recent techniques are presented in a systematic fashion. The contribution of this paper is to provide an extensive account of registration techniques in a systematic manner. PMID:23739795

  19. Foodborne listeriosis acquired in hospitals.

    PubMed

    Silk, Benjamin J; McCoy, Morgan H; Iwamoto, Martha; Griffin, Patricia M

    2014-08-15

    Listeriosis is characterized by bacteremia or meningitis. We searched for listeriosis case series and outbreak investigations published in English by 2013, and assessed the strength of evidence for foodborne acquisition among patients who ate hospital food. We identified 30 reports from 13 countries. Among the case series, the median proportion of cases considered to be hospital-acquired was 25% (range, 9%-67%). The median number of outbreak-related illnesses considered to be hospital-acquired was 4.0 (range, 2-16). All patients were immunosuppressed in 18 of 24 (75%) reports with available data. Eight outbreak reports with strong evidence for foodborne acquisition in a hospital implicated sandwiches (3 reports), butter, precut celery, Camembert cheese, sausage, and tuna salad (1 report each). Foodborne acquisition of listeriosis among hospitalized patients is well documented internationally. The number of listeriosis cases could be reduced substantially by establishing hospital policies for safe food preparation for immunocompromised patients and by not serving them higher-risk foods.

  20. Experimental Deformation of Magnetite

    NASA Astrophysics Data System (ADS)

    Till, J. L.; Rybacki, E.; Morales, L. F. G.

    2015-12-01

    Magnetite is an important iron ore mineral and the most prominent Fe-oxide phase in the Earth's crust. The systematic occurrence of magnetite in zones of intense deformation in oceanic core complexes suggests that it may play a role in strain localization in some silicate rocks. We performed a series of high-temperature deformation experiments on synthetic magnetite aggregates and natural single crystals to characterize the rheological behavior of magnetite. As starting material, we used fine-grained magnetite powder that was hot isostatically pressed at 1100°C for several hours, resulting in polycrystalline material with a mean grain size of around 40 μm and containing 3-5% porosity. Samples were deformed to 15-20% axial strain under constant load (approximating constant stress) conditions in a Paterson-type gas apparatus for triaxial deformation at temperatures between 900 and 1100°C and 300 MPa confining pressure. The aggregates exhibit typical power-law creep behavior. At high stresses, samples deformed by dislocation creep exhibit stress exponents close to 3, revealing a transition to near-Newtonian creep with stress exponents around 1.3 at lower stresses. Natural magnetite single crystals deformed at 1 atm pressure and temperatures between 950°C and 1150 °C also exhibit stress exponents close to 3, but with lower flow stresses and a lower apparent activation energy than the aggregates. Such behavior may result from the different oxygen fugacity buffers used. Crystallographic-preferred orientations in all polycrystalline samples are very weak and corroborate numerical models of CPO development, suggesting that texture development in magnetite may be inherently slow compared with lower symmetry phases. Comparison of our results with experimental deformation data for various silicate minerals suggests that magnetite should be weaker than most silicates during ductile creep in dry igneous rocks.

  1. Bejel: acquirable only in childhood?

    PubMed

    Rothschild, Bruce M; Rothschild, Christine; Naples, Virginia; Billard, Michel; Panero, Barbara

    2006-10-01

    Bejel clearly has a long history in the Middle East and the Sudan, but was it transmitted to Europe? As the major manifestation of bejel is presence of periosteal reaction in 20-40% of afflicted populations, absence of significant population frequency of periosteal reaction in Europe would exclude that diagnosis. Examination of skeletal populations from continental Europe revealed no significant periosteal reaction at the time of and immediately subsequent to the Crusades. Thus, there is no evidence for bejel in Europe, in spite of clear contact (the mechanism of bejel transmission in children) between warring groups, at least during the Crusades. This supports the hypothesis that bejel is a childhood-acquired disease and apparently cannot be contracted in adulthood.

  2. 7 CFR 926.10 - Acquire.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... REQUIREMENTS APPLICABLE TO CRANBERRIES NOT SUBJECT TO THE CRANBERRY MARKETING ORDER § 926.10 Acquire. Acquire means to obtain cranberries by any means whatsoever for the purpose of handling cranberries....

  3. 7 CFR 926.10 - Acquire.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... REQUIREMENTS APPLICABLE TO CRANBERRIES NOT SUBJECT TO THE CRANBERRY MARKETING ORDER § 926.10 Acquire. Acquire means to obtain cranberries by any means whatsoever for the purpose of handling cranberries....

  4. 7 CFR 926.10 - Acquire.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... REQUIREMENTS APPLICABLE TO CRANBERRIES NOT SUBJECT TO THE CRANBERRY MARKETING ORDER § 926.10 Acquire. Acquire means to obtain cranberries by any means whatsoever for the purpose of handling cranberries....

  5. 7 CFR 926.10 - Acquire.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... REQUIREMENTS APPLICABLE TO CRANBERRIES NOT SUBJECT TO THE CRANBERRY MARKETING ORDER § 926.10 Acquire. Acquire means to obtain cranberries by any means whatsoever for the purpose of handling cranberries....

  6. 7 CFR 926.10 - Acquire.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... REQUIREMENTS APPLICABLE TO CRANBERRIES NOT SUBJECT TO THE CRANBERRY MARKETING ORDER § 926.10 Acquire. Acquire means to obtain cranberries by any means whatsoever for the purpose of handling cranberries....

  7. Acquired haemophilia in recipients of depot thioxanthenes.

    PubMed

    Stewart, A J; Manson, L M; Dasani, H; Beddall, A; Collins, P; Shima, M; Ludlam, C A

    2000-11-01

    We present two cases in which the occurrence of acquired haemophilia is associated with the use of depot preparations of the thioxanthenes zuclopenthixol and flupenthixol. These drugs have not previously been implicated in the aetiology of acquired haemophilia.

  8. Acquiring Evolving Technologies: Web Services Standards

    DTIC Science & Technology

    2016-06-30

    2006 Carnegie Mellon University Acquiring Evolving Technologies : Web Services Standards Harry L. Levinson Software Engineering Institute Carnegie...Acquiring Evolving Technologies : Web Services Standards 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT...298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 2 Acquiring Evolving Technologies : Web Services Standards © 2006 Carnegie Mellon University Acquiring

  9. Crustal deformation and earthquakes

    NASA Technical Reports Server (NTRS)

    Cohen, S. C.

    1984-01-01

    The manner in which the Earth's surface deforms during the cycle of stress accumulation and release along major faults is investigated. In an investigation of the crustal deformation associated with a thin channel asthenosphere displacements are reduced from those computed for a half space asthenosphere. A previous finding by other workers that displacements are enhanced when flow is confined to a thin channel is based on several invalid approximations. The major predictions of the finite element model are that the near field postseismic displacements and strain rates are less than those for a half space asthenosphere and that the postseismic strain rates at intermediate distances are greater (in magnitude). The finite width of the asthenosphere ceases to have a significant impact on the crustal deformation pattern when its magnitude exceeds about three lithosphere thicknesses.

  10. Interfacial Bubble Deformations

    NASA Astrophysics Data System (ADS)

    Seymour, Brian; Shabane, Parvis; Cypull, Olivia; Cheng, Shengfeng; Feitosa, Klebert

    Soap bubbles floating at an air-water experience deformations as a result of surface tension and hydrostatic forces. In this experiment, we investigate the nature of such deformations by taking cross-sectional images of bubbles of different volumes. The results show that as their volume increases, bubbles transition from spherical to hemispherical shape. The deformation of the interface also changes with bubble volume with the capillary rise converging to the capillary length as volume increases. The profile of the top and bottom of the bubble and the capillary rise are completely determined by the volume and pressure differences. James Madison University Department of Physics and Astronomy, 4VA Consortium, Research Corporation for Advancement of Science.

  11. Plate motion and deformation

    SciTech Connect

    Minster, B.; Prescott, W.; Royden, L.

    1991-02-01

    Our goal is to understand the motions of the plates, the deformation along their boundaries and within their interiors, and the processes that control these tectonic phenomena. In the broadest terms, we must strive to understand the relationships of regional and local deformation to flow in the upper mantle and the rheological, thermal and density structure of the lithosphere. The essential data sets which we require to reach our goal consist of maps of current strain rates at the earth's surface and the distribution of integrated deformation through time as recorded in the geologic record. Our success will depend on the effective synthesis of crustal kinematics with a variety of other geological and geophysical data, within a quantitative theoretical framework describing processes in the earth's interior. Only in this way can we relate the snapshot of current motions and earth structure provided by geodetic and geophysical data with long-term processes operating on the time scales relevant to most geological processes. The wide-spread use of space-based techniques, coupled with traditional geological and geophysical data, promises a revolution in our understanding of the kinematics and dynamics of plate motions over a broad range of spatial and temporal scales and in a variety of geologic settings. The space-based techniques that best address problems in plate motion and deformation are precise space-geodetic positioning -- on land and on the seafloor -- and satellite acquisition of detailed altimetric and remote sensing data in oceanic and continental areas. The overall science objectives for the NASA Solid Earth Science plan for the 1990's, are to Understand the motion and deformation of the lithosphere within and across plate boundaries'', and to understand the dynamics of the mantle, the structure and evolution of the lithosphere, and the landforms that result from local and regional deformation. 57 refs., 7 figs., 2 tabs.

  12. Nanolaminate deformable mirrors

    DOEpatents

    Papavasiliou, Alexandros P.; Olivier, Scot S.

    2009-04-14

    A deformable mirror formed out of two layers of a nanolaminate foil attached to a stiff substrate is introduced. Deformation is provided by an electrostatic force between two of the layers. The internal stiffness of the structure allows for high-spatial-frequency shapes. The nanolaminate foil of the present invention allows for a high-quality mirror surface. The device achieves high precision in the vertical direction by using foils with accurately controlled thicknesses, but does not require high precision in the lateral dimensions, allowing such mirrors to be fabricated using crude lithography techniques. Such techniques allow structures up to about the meter scale to be fabricated.

  13. Nanolaminate deformable mirrors

    DOEpatents

    Papavasiliou, Alexandros P.; Olivier, Scot S.

    2010-04-06

    A deformable mirror formed out of two layers of a nanolaminate foil attached to a stiff substrate is introduced. Deformation is provided by an electrostatic force between two of the layers. The internal stiffness of the structure allows for high-spatial-frequency shapes. The nanolaminate foil of the present invention allows for a high-quality mirror surface. The device achieves high precision in the vertical direction by using foils with accurately controlled thicknesses, but does not require high precision in the lateral dimensions, allowing such mirrors to be fabricated using crude lithography techniques. Such techniques allow structures up to about the meter scale to be fabricated.

  14. Micromachined, Electrostatically Deformable Reflectors

    NASA Technical Reports Server (NTRS)

    Bartman, Randall K.; Wang, Paul K. C.; Miller, Linda M.; Kenny, Thomas W.; Kaiser, William J.; Hadaegh, Fred Y.; Agronin, Michael L.

    1995-01-01

    Micromachined, closed-loop, electrostatically actuated reflectors (microCLEARs) provide relatively simple and inexpensive alternatives to large, complex, expensive adaptive optics used to control wavefronts of beams of light in astronomy and in experimental laser weapons. Micromachining used to make deformable mirror, supporting structure, and actuation circuitry. Development of microCLEARs may not only overcome some of disadvantages and limitations of older adaptive optics but may also satisfy demands of potential market for small, inexpensive deformable mirrors in electronically controlled film cameras, video cameras, and other commercial optoelectronic instruments.

  15. Corticomotoneuronal function and hyperexcitability in acquired neuromyotonia.

    PubMed

    Vucic, Steve; Cheah, Benjamin C; Yiannikas, Con; Vincent, Angela; Kiernan, Matthew C

    2010-09-01

    Acquired neuromyotonia encompasses a group of inflammatory disorders characterized by symptoms reflecting peripheral nerve hyperexcitability, which may be clinically confused in the early stages with amyotrophic lateral sclerosis. Despite a clear peripheral nerve focus, it remains unclear whether the ectopic activity in acquired neuromyotonia receives a central contribution. To clarify whether cortical hyperexcitability contributes to development of clinical features of acquired neuromyotonia, the present study investigated whether threshold tracking transcranial magnetic stimulation could detect cortical hyperexcitability in acquired neuromyotonia, and whether this technique could differentiate acquired neuromyotonia from amyotrophic lateral sclerosis. Cortical excitability studies were undertaken in 18 patients with acquired neuromyotonia and 104 patients with amyotrophic lateral sclerosis, with results compared to 62 normal controls. Short-interval intracortical inhibition in patients with acquired neuromyotonia was significantly different when compared to patients with amyotrophic lateral sclerosis (averaged short interval intracortical inhibition acquired neuromyotonia 11.3 +/- 1.9%; amyotrophic lateral sclerosis 2.6 +/- 0.9%, P < 0.001). In addition, the motor evoked potential amplitudes (acquired neuromyotonia 21.0 +/- 3.1%; amyotrophic lateral sclerosis 38.1 +/- 2.2%, P < 0.0001), intracortical facilitation (acquired neuromyotonia -0.9 +/- 1.3%; amyotrophic lateral sclerosis -2.3 +/- 0.6%, P < 0.0001), resting motor thresholds (acquired neuromyotonia 62.2 +/- 1.6%; amyotrophic lateral sclerosis 57.2 +/- 0.9%, P < 0.05) and cortical silent period durations (acquired neuromyotonia 212.8 +/- 6.9 ms; amyotrophic lateral sclerosis 181.1 +/- 4.3 ms, P < 0.0001) were significantly different between patients with acquired neuromyotonia and amyotrophic lateral sclerosis. Threshold tracking transcranial magnetic stimulation established corticomotoneuronal integrity

  16. Associative Learning Through Acquired Salience

    PubMed Central

    Treviño, Mario

    2016-01-01

    Most associative learning studies describe the salience of stimuli as a fixed learning-rate parameter. Presumptive saliency signals, however, have also been linked to motivational and attentional processes. An interesting possibility, therefore, is that discriminative stimuli could also acquire salience as they become powerful predictors of outcomes. To explore this idea, we first characterized and extracted the learning curves from mice trained with discriminative images offering varying degrees of structural similarity. Next, we fitted a linear model of associative learning coupled to a series of mathematical representations for stimulus salience. We found that the best prediction, from the set of tested models, was one in which the visual salience depended on stimulus similarity and a non-linear function of the associative strength. Therefore, these analytic results support the idea that the net salience of a stimulus depends both on the items' effective salience and the motivational state of the subject that learns about it. Moreover, this dual salience model can explain why learning about a stimulus not only depends on the effective salience during acquisition but also on the specific learning trajectory that was used to reach this state. Our mathematical description could be instrumental for understanding aberrant salience acquisition under stressful situations and in neuropsychiatric disorders like schizophrenia, obsessive-compulsive disorder, and addiction. PMID:26793078

  17. Inherited or acquired metabolic disorders.

    PubMed

    Eichler, Florian; Ratai, Eva; Carroll, Jason J; Masdeu, Joseph C

    2016-01-01

    This chapter starts with a description of imaging of inherited metabolic disorders, followed by a discussion on imaging of acquired toxic-metabolic disorders of the adult brain. Neuroimaging is crucial for the diagnosis and management of a number of inherited metabolic disorders. Among these, inherited white-matter disorders commonly affect both the nervous system and endocrine organs. Magnetic resonance imaging (MRI) has enabled new classifications of these disorders that have greatly enhanced both our diagnostic ability and our understanding of these complex disorders. Beyond the classic leukodystrophies, we are increasingly recognizing new hereditary leukoencephalopathies such as the hypomyelinating disorders. Conventional imaging can be unrevealing in some metabolic disorders, but proton magnetic resonance spectroscopy (MRS) may be able to directly visualize the metabolic abnormality in certain disorders. Hence, neuroimaging can enhance our understanding of pathogenesis, even in the absence of a pathologic specimen. This review aims to present pathognomonic brain MRI lesion patterns, the diagnostic capacity of proton MRS, and information from clinical and laboratory testing that can aid diagnosis. We demonstrate that applying an advanced neuroimaging approach enhances current diagnostics and management. Additional information on inherited and metabolic disorders of the brain can be found in Chapter 63 in the second volume of this series.

  18. 17 CFR 210.8-06 - Real estate operations acquired or to be acquired.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Real estate operations acquired or to be acquired. 210.8-06 Section 210.8-06 Commodity and Securities Exchanges SECURITIES AND... Statements of Smaller Reporting Companies § 210.8-06 Real estate operations acquired or to be acquired....

  19. Acquired immune deficiency syndrome: review.

    PubMed

    Scully, C; Cawson, R A; Porter, S R

    1986-07-19

    Acquired immunodeficiency syndrome (AIDS) is reviewed for dental practitioners, with an emphasis on oral findings; the clinical course, diagnosis, reporting, treatment, prognosis, transmission, and epidemiology are also covered. HIV infection has an incubation period that may be associated with glandular fever, a prodrome called AIDS-Related Complex (ARC) characterized by lymphadenopathy, low fever, weight loss, night sweats, diarrhea, oral candidosis, nonproductive cough and recurrent infections. AIDS is characterized by opportunistic infections. Over 50% present with pneumocystis carinii pneumonia, 21% with Kaposi's sarcoma, and 6% have both. The AIDS virus causes direct neurological symptoms in some cases. Oral candidosis (thrush) in a young male without a local cause such as xerostomia or immune suppression is strongly suggestive of AIDS. Other oral manifestations are severe herpes simplex, varicella-zoster, Epstein-Barr virus, cytomegalovirus, venereal warts, aphthous ulceration, mycobacterial oral ulcers, oral histoplasmosis, sinusitis and osteomyelitis of the jaw. Hairy leukoplakia, usually seen on the lateral border of the tongue, is probably caused by Epstein-Barr virus. Kaposi's sarcoma, an endothelial cell tumor, is characteristic of AIDS, and in 50% of patients is oral or perioral. Cervical lymph node enlargement will be seen in those with ARC as well as AIDS. No guidelines have been issued by the Department of Health and Social Security for dental surgeons in the UK for reporting AIDS cases. Although HIV virions have been isolated from saliva, there are no known incidents of transmission via saliva. HIV is less likely to be transmitted by needle stick injuries than, for example hepatitis B (25% risk), especially if the blood is from a carrier rather than a full blown AIDS case.

  20. Clinicopathological associations of acquired erythroblastopenia

    PubMed Central

    Gunes, Gursel; Malkan, Umit Yavuz; Yasar, Hatime Arzu; Eliacik, Eylem; Haznedaroglu, Ibrahim Celalettin; Demiroglu, Haluk; Sayinalp, Nilgun; Aksu, Salih; Etgul, Sezgin; Aslan, Tuncay; Goker, Hakan; Ozcebe, Osman Ilhami; Buyukasik, Yahya

    2015-01-01

    Introduction: Acquired erythroblastopenia (AE) is a rare clinical situation. It is characterized by the reduction of erythroid precursors in the bone marrow together with the low reticulocyte counts in the peripheral blood. Background: Main secondary causes of AE are drugs, Parvovirus B19 and other infectious reasons, lymphoid and myeloid neoplasia, autoimmune diseases, thymoma and pregnancy. The aim of this study is to assess the frequencies and clinical associations of AE via analyzing 12340 bone marrow samples in a retrospective manner. Material and method: Bone marrow aspirations which were obtained from patients who applied to Hacettepe University Hematology Clinic between 2002 and 2013, were analyzed retrospectively. Results: Thirty four erythroblastopenia cases were found. Patients ranged in age from 16 to 80 years with a median of 38 years. Fifteen patients were men (44%) and nineteen were women (56%). In these patients, detected causes of erythroblastopenia were MDS, idiopathic pure red cell aplasia (PRCA), parvovirus infection, post chemotherapy aplasia, plasma proliferative diseases, copper deficiency due to secondary amyloidosis, fever of unknown origin, hemophagocytic syndrome, enteric fever and legionella pneumonia. We found that between those reasons the most common causes of erythroblastopenia are MDS (17.7%) and idiopathic PRCA (17.7%). Discussion: As a result, erythroblastopenia in the bone marrow may be an early sign of MDS. In those AE cases possibility of being MDS must be kept in mind as it can be mistaken for PRCA. Conclusion: To conclude, in adults MDS without excess blast is one of the most common causes of erythroblastopenia in clinical practice and in case of erythroblastopenia the presence of MDS should be investigated. PMID:26885236

  1. Nanoscale deformation mechanisms in bone.

    PubMed

    Gupta, Himadri S; Wagermaier, Wolfgang; Zickler, Gerald A; Raz-Ben Aroush, D; Funari, Sérgio S; Roschger, Paul; Wagner, H Daniel; Fratzl, Peter

    2005-10-01

    Deformation mechanisms in bone matrix at the nanoscale control its exceptional mechanical properties, but the detailed nature of these processes is as yet unknown. In situ tensile testing with synchrotron X-ray scattering allowed us to study directly and quantitatively the deformation mechanisms at the nanometer level. We find that bone deformation is not homogeneous but distributed between a tensile deformation of the fibrils and a shearing in the interfibrillar matrix between them.

  2. Probing deformed quantum commutators

    NASA Astrophysics Data System (ADS)

    Rossi, Matteo A. C.; Giani, Tommaso; Paris, Matteo G. A.

    2016-07-01

    Several quantum gravity theories predict a minimal length at the order of magnitude of the Planck length, under which the concepts of space and time lose their physical meaning. In quantum mechanics, the insurgence of such a minimal length can be described by introducing a modified position-momentum commutator, which in turn yields a generalized uncertainty principle, where the uncertainty on position measurements has a lower bound. The value of the minimal length is not predicted by theories and must be estimated experimentally. In this paper, we address the quantum bound to the estimability of the minimal uncertainty length by performing measurements on a harmonic oscillator, which is analytically solvable in the deformed algebra induced by the deformed commutation relations.

  3. [Babies with cranial deformity].

    PubMed

    Feijen, Michelle M W; Claessens, Edith A W M Habets; Dovens, Anke J Leenders; Vles, Johannes S; van der Hulst, Rene R W J

    2009-01-01

    Plagiocephaly was diagnosed in a baby aged 4 months and brachycephaly in a baby aged 5 months. Positional or deformational plagio- or brachycephaly is characterized by changes in shape and symmetry of the cranial vault. Treatment options are conservative and may include physiotherapy and helmet therapy. During the last two decades the incidence of positional plagiocephaly has increased in the Netherlands. This increase is due to the recommendation that babies be laid on their backs in order to reduce the risk of sudden infant death syndrome. We suggest the following: in cases of positional preference of the infant, referral to a physiotherapist is indicated. In cases of unacceptable deformity of the cranium at the age 5 months, moulding helmet therapy is a possible treatment option.

  4. Partially segmented deformable mirror

    DOEpatents

    Bliss, Erlan S.; Smith, James R.; Salmon, J. Thaddeus; Monjes, Julio A.

    1991-01-01

    A partially segmented deformable mirror is formed with a mirror plate having a smooth and continuous front surface and a plurality of actuators to its back surface. The back surface is divided into triangular areas which are mutually separated by grooves. The grooves are deep enough to make the plate deformable and the actuators for displacing the mirror plate in the direction normal to its surface are inserted in the grooves at the vertices of the triangular areas. Each actuator includes a transducer supported by a receptacle with outer shells having outer surfaces. The vertices have inner walls which are approximately perpendicular to the mirror surface and make planar contacts with the outer surfaces of the outer shells. The adhesive which is used on these contact surfaces tends to contract when it dries but the outer shells can bend and serve to minimize the tendency of the mirror to warp.

  5. Partially segmented deformable mirror

    DOEpatents

    Bliss, E.S.; Smith, J.R.; Salmon, J.T.; Monjes, J.A.

    1991-05-21

    A partially segmented deformable mirror is formed with a mirror plate having a smooth and continuous front surface and a plurality of actuators to its back surface. The back surface is divided into triangular areas which are mutually separated by grooves. The grooves are deep enough to make the plate deformable and the actuators for displacing the mirror plate in the direction normal to its surface are inserted in the grooves at the vertices of the triangular areas. Each actuator includes a transducer supported by a receptacle with outer shells having outer surfaces. The vertices have inner walls which are approximately perpendicular to the mirror surface and make planar contacts with the outer surfaces of the outer shells. The adhesive which is used on these contact surfaces tends to contract when it dries but the outer shells can bend and serve to minimize the tendency of the mirror to warp. 5 figures.

  6. Toward the development of intrafraction tumor deformation tracking using a dynamic multi-leaf collimator

    SciTech Connect

    Ge, Yuanyuan; O’Brien, Ricky T.; Shieh, Chun-Chien; Keall, Paul J.; Booth, Jeremy T.

    2014-06-15

    Purpose: Intrafraction deformation limits targeting accuracy in radiotherapy. Studies show tumor deformation of over 10 mm for both single tumor deformation and system deformation (due to differential motion between primary tumors and involved lymph nodes). Such deformation cannot be adapted to with current radiotherapy methods. The objective of this study was to develop and experimentally investigate the ability of a dynamic multi-leaf collimator (DMLC) tracking system to account for tumor deformation. Methods: To compensate for tumor deformation, the DMLC tracking strategy is to warp the planned beam aperture directly to conform to the new tumor shape based on real time tumor deformation input. Two deformable phantoms that correspond to a single tumor and a tumor system were developed. The planar deformations derived from the phantom images in beam's eye view were used to guide the aperture warping. An in-house deformable image registration software was developed to automatically trigger the registration once new target image was acquired and send the computed deformation to the DMLC tracking software. Because the registration speed is not fast enough to implement the experiment in real-time manner, the phantom deformation only proceeded to the next position until registration of the current deformation position was completed. The deformation tracking accuracy was evaluated by a geometric target coverage metric defined as the sum of the area incorrectly outside and inside the ideal aperture. The individual contributions from the deformable registration algorithm and the finite leaf width to the tracking uncertainty were analyzed. Clinical proof-of-principle experiment of deformation tracking using previously acquired MR images of a lung cancer patient was implemented to represent the MRI-Linac environment. Intensity-modulated radiation therapy (IMRT) treatment delivered with enabled deformation tracking was simulated and demonstrated. Results: The first

  7. Cryptosporidiosis in the acquired immune deficiency syndrome.

    PubMed

    Cooper, D A; Wodak, A; Marriot, D J; Harkness, J L; Ralston, M; Hill, A; Penny, R

    1984-10-01

    Cryptosporidiosis was found in a patient with the acquired immune deficiency syndrome. The microbiological and morphological features of this newly recognized opportunistic infection are distinctive and diagnostic.

  8. Osteotomies for bunionette deformity.

    PubMed

    Weil, Lowell; Weil, Lowell Scott

    2011-12-01

    A variety of surgical osteotomy procedures have been described for the bunionette deformity.Metatarsal osteotomies narrow the forefoot, maintain the length of the metatarsal, and preserve function of the metatarsophalangeal joint. Distal metatarsal osteotomies produce less correction and reduce postoperative disability; however, they pose a risk of inadequate correction because of the small width of the fifth metatarsal head and transfer lesions if shortened or dorsiflexed excessively. The sliding oblique metaphyseal osteotomy described by Smith and Weil (without fixation) and later by Steinke (with fixation) is easy to perform and provides good cancellous bone contact. Fixation is sometimes difficult and bone healing can take a few months owing to the unstable construct of this osteotomy. Kitaoka described a distal chevron osteotomy, which provides lateral pressure relief and reduced plantar pressure. This osteotomy is currently the most common procedure used; however, it may prove difficult to perform if the deformity is large and the bone is narrow. Diaphyseal osteotomies are indicated when greater correction is needed; however, they require more dissection and there is greater postoperative convalescence with non–weight bearing for several weeks. Proximal base osteotomies may be used to address significantly increased 4–5 IMAs or when a large degree of sagittal plane correction is required. Approaches that have been described include opening and closing base wedges and basal chevrons. Advantages to this approach are the ability to avoid epiphyseal plates in pediatric patients and maintain function of the MTPJ, while disadvantages include inherent instability of the location of the osteotomy, embarrassment of intraosseous and extraosseus blood supply of the metatarsal, and technical demand. Non–weight bearing is essential for several weeks. The Scarfette procedure is a combination head–shaft procedure, which is indicated to treat mild to moderate

  9. Covariant deformed oscillator algebras

    NASA Technical Reports Server (NTRS)

    Quesne, Christiane

    1995-01-01

    The general form and associativity conditions of deformed oscillator algebras are reviewed. It is shown how the latter can be fulfilled in terms of a solution of the Yang-Baxter equation when this solution has three distinct eigenvalues and satisfies a Birman-Wenzl-Murakami condition. As an example, an SU(sub q)(n) x SU(sub q)(m)-covariant q-bosonic algebra is discussed in some detail.

  10. Advanced Curvature Deformable Mirrors

    DTIC Science & Technology

    2010-09-01

    designs using just a glass wafer and a wafer of Carbon Fiber Reinforced Polymer ( CFRP ). In both cases minimum bend radius decreases and the resonant... matrix is consequently nearly diagonal. The long actuators at the outer edge of the deformable mirror are largely outside the working pupil so their...formal reconstruction of the wave front either explicitly or implicitly in the control matrix . The WFS-DM combination is acting like an analog computer

  11. Deformation of Wrinkled Graphene

    PubMed Central

    2015-01-01

    The deformation of monolayer graphene, produced by chemical vapor deposition (CVD), on a polyester film substrate has been investigated through the use of Raman spectroscopy. It has been found that the microstructure of the CVD graphene consists of a hexagonal array of islands of flat monolayer graphene separated by wrinkled material. During deformation, it was found that the rate of shift of the Raman 2D band wavenumber per unit strain was less than 25% of that of flat flakes of mechanically exfoliated graphene, whereas the rate of band broadening per unit strain was about 75% of that of the exfoliated material. This unusual deformation behavior has been modeled in terms of mechanically isolated graphene islands separated by the graphene wrinkles, with the strain distribution in each graphene island determined using shear lag analysis. The effect of the size and position of the Raman laser beam spot has also been incorporated in the model. The predictions fit well with the behavior observed experimentally for the Raman band shifts and broadening of the wrinkled CVD graphene. The effect of wrinkles upon the efficiency of graphene to reinforce nanocomposites is also discussed. PMID:25765609

  12. Deformable micro torque swimmer

    NASA Astrophysics Data System (ADS)

    Ishikawa, Takuji; Tanaka, Tomoyuki; Omori, Toshihiro; Imai, Yohsuke

    2015-11-01

    We investigated the deformation of a ciliate swimming freely in a fluid otherwise at rest. The cell body was modeled as a capsule with a hyper elastic membrane enclosing Newtonian fluid. Thrust forces due to the ciliary beat were modeled as torques distributed above the cell body. Effects of the membrane elasticity, the aspect ratio of cell's reference shape and the density difference between the cell and the surrounding fluid were investigated. The results showed that the cell deformed like heart shape when Capillary number (Ca) was sufficiently large, and the swimming velocity decreased as Ca was increased. The gravity effect on the membrane tension suggested that the upwards and downwards swimming velocities of Paramecium might be reglated by the calcium ion channels distributed locally around the anterior end. Moreover, the gravity induced deformation made a cell directed vertically downwards, which resulted in a positive geotaxis like behavior with physical origin. These results are important to understand physiology of ciliate's biological responses to mechanical stimuli.

  13. [Neurogenic foot deformities].

    PubMed

    Senst, S

    2010-01-01

    There is a multitude of neurological diseases which may lead to neuro-orthopaedic problems and subsequently to neurogenic foot deformities. For this reason the diagnostician will be consistently surprised that there is a great multitude of different foot abnormalities and that not only the typical spastic talipes equines dominates. Of particular significance here is that these deformities almost always develop progressively, whereas most diseases persist per se, cerebral palsy being a typical case in point. However, in MMC (myelomeningocele) patients, there is also the danger of a worsening of the basic problem in the case of tethered cord syndrome. Unlike congenital talipes equinovarus, neuro-orthopaedic talipes equinovarus often shows over- or undercorrection postoperatively due to a shift in muscle imbalance. It is important, therefore, that the basis of conservative therapy include regular physiotherapy and orthoses during the day and, if necessary, at night. Botulinum toxin has been established as an additional measure for spasticity; however, this cannot always prevent surgical intervention, but is able to delay this to a better point in the development of the child/patient. The present article describes the diversity of neurological deformities and presents conservative as well as surgical therapeutic approaches.

  14. Nanoscale Deformable Optics

    NASA Technical Reports Server (NTRS)

    Strauss, Karl F.; Sheldon, Douglas J.

    2011-01-01

    Several missions and instruments in the conceptual design phase rely on the technique of interferometry to create detectable fringe patterns. The intimate emplacement of reflective material upon electron device cells based upon chalcogenide material technology permits high-speed, predictable deformation of the reflective surface to a subnanometer or finer resolution with a very high degree of accuracy. In this innovation, a layer of reflective material is deposited upon a wafer containing (perhaps in the millions) chalcogenic memory cells with the reflective material becoming the front surface of a mirror and the chalcogenic material becoming a means of selectively deforming the mirror by the application of heat to the chalcogenic material. By doing so, the mirror surface can deform anywhere from nil to nanometers in spots the size of a modern day memory cell, thereby permitting realtime tuning of mirror focus and reflectivity to mitigate aberrations caused elsewhere in the optical system. Modern foundry methods permit the design and manufacture of individual memory cells having an area of or equal to the Feature (F) size of the design (assume 65 nm). Fabrication rules and restraints generally require the instantiation of one memory cell to another no closer than 1.5 F, or, for this innovation, 90 nm from its neighbor in any direction. Chalcogenide is a semiconducting glass compound consisting of a combination of chalcogen ions, the ratios of which vary according to properties desired. It has been shown that the application of heat to cells of chalcogenic material cause a large alteration in resistance to the range of 4 orders of magnitude. It is this effect upon which chalcogenidebased commercial memories rely. Upon removal of the heat source, the chalcogenide rapidly cools and remains frozen in the excited state. It has also been shown that the chalcogenide expands in volume because of the applied heat, meaning that the coefficient of expansion of chalcogenic

  15. Model Deformation Measurements at a Cryogenic Wind Tunnel Using Photogrammetry

    NASA Technical Reports Server (NTRS)

    Burner, A. W.; Snow, W. L.; Goad, W. K.

    1982-01-01

    A photogrammetric closed circuit television system to measure model deformation at the National Transonic Facility (NTF) is described. The photogrammetric approach was chosen because of its inherent rapid data recording of the entire object field. Video cameras are used to acquire data instead of film cameras due to the inaccessibility of cameras which must be housed within the cryogenic, high pressure plenum of this facility. Data reduction procedures and the results of tunnel tests at the NTF are presented.

  16. Acquiring and Managing Electronic Journals. ERIC Digest.

    ERIC Educational Resources Information Center

    Curtis, Donnelyn; Yue, Paoshan

    Electronic journals are both a blessing and a curse for libraries. To be meaningful in the current information environment--to meet users' ever-increasing demands--libraries must acquire as many appropriate full text resources as possible, as quickly as possible, and make them easy to use. This Digest provides tips for acquiring and providing…

  17. Acquired idiopathic generalized anhidrosis: case report.

    PubMed

    Brantley, Elise I; Mutasim, Diya F; Heaton, Charles

    2011-01-01

    We report a case of acquired idiopathic generalized anhidrosis (AIGA) in a 56-year-old white woman. Acquired idiopathic generalized anhidrosis is an exceedingly rare group of heterogeneous disorders that has been almost exclusively reported in young Japanese males. Our case is unique in that AlGA may be underrecognized in this patient population.

  18. Monitoring Surface Deformation using Polarimetric Ground Based Interferometric Radar

    NASA Astrophysics Data System (ADS)

    Legarsky, J. J.; Gomez, F.; Rosenblad, B.; Loehr, E.; Cherukumilli, S.; Deng, H.; Held, B.; Jenkins, W.

    2012-12-01

    Surface deformation monitoring using ground based interferometric radar (GBIR) measurements may be desirable for a number of applications in the earth sciences. The University of Missouri (MU) research team has ongoing efforts to use the MU GBIR for monitoring surface deformation at a number of sites. Measurements have been collected at sites requiring access by various transportation means such as using off-road vehicle, hiking, and helicopter. Once on site, initial setup takes about 10 minutes. After setup, an image may be acquired by azimuth scan about every 20 seconds. The highly portable system lends itself to rapid deployment in remote environments and repeat survey sites. The MU GBIR's high portability and fast imaging capabilities allow rapid surveying and long-term surveying potential of surface deformation. Imagery may be formed in near real time for initial quick looks. After data collection, imagery data may be further enhanced by radiometric calibration, polarimetric calibration, and time-series analysis. Imaging may be acquired at the electromagnetic spectral bands of C-band and Ku-band. Prior demonstration of millimeter and better sensitivity to deformation over the course of a day of data collects has been performed using the MU GBIR. In addition, the MU GBIR can be removed and re-positioned at the same point with geodetic-grade precision for repeat surveys. Study results and additional development progress will be presented. This project is sponsored by a grant from the National Science Foundation.

  19. Smoothly deformed light

    NASA Technical Reports Server (NTRS)

    Stenholm, Stig

    1993-01-01

    A single mode cavity is deformed smoothly to change its electromagnetic eigenfrequency. The system is modeled as a simple harmonic oscillator with a varying period. The Wigner function of the problem is obtained exactly by starting with a squeezed initial state. The result is evaluated for a linear change of the cavity length. The approach to the adiabatic limit is investigated. The maximum squeezing is found to occur for smooth change lasting only a fraction of the oscillational period. However, only a factor of two improvement over the adiabatic result proves to be possible. The sudden limit cannot be investigated meaningfully within the model.

  20. Patient-specific Deformation Modelling via Elastography: Application to Image-guided Prostate Interventions

    NASA Astrophysics Data System (ADS)

    Wang, Yi; Ni, Dong; Qin, Jing; Xu, Ming; Xie, Xiaoyan; Heng, Pheng-Ann

    2016-06-01

    Image-guided prostate interventions often require the registration of preoperative magnetic resonance (MR) images to real-time transrectal ultrasound (TRUS) images to provide high-quality guidance. One of the main challenges for registering MR images to TRUS images is how to estimate the TRUS-probe-induced prostate deformation that occurs during TRUS imaging. The combined statistical and biomechanical modeling approach shows promise for the adequate estimation of prostate deformation. However, the right setting of the biomechanical parameters is very crucial for realistic deformation modeling. We propose a patient-specific deformation model equipped with personalized biomechanical parameters obtained from shear wave elastography to reliably predict the prostate deformation during image-guided interventions. Using data acquired from a prostate phantom and twelve patients with suspected prostate cancer, we compared the prostate deformation model with and without patient-specific biomechanical parameters in terms of deformation estimation accuracy. The results show that the patient-specific deformation model possesses favorable model ability, and outperforms the model without patient-specific biomechanical parameters. The employment of the patient-specific biomechanical parameters obtained from elastography for deformation modeling shows promise for providing more precise deformation estimation in applications that use computer-assisted image-guided intervention systems.

  1. Patient-specific Deformation Modelling via Elastography: Application to Image-guided Prostate Interventions

    PubMed Central

    Wang, Yi; Ni, Dong; Qin, Jing; Xu, Ming; Xie, Xiaoyan; Heng, Pheng-Ann

    2016-01-01

    Image-guided prostate interventions often require the registration of preoperative magnetic resonance (MR) images to real-time transrectal ultrasound (TRUS) images to provide high-quality guidance. One of the main challenges for registering MR images to TRUS images is how to estimate the TRUS-probe-induced prostate deformation that occurs during TRUS imaging. The combined statistical and biomechanical modeling approach shows promise for the adequate estimation of prostate deformation. However, the right setting of the biomechanical parameters is very crucial for realistic deformation modeling. We propose a patient-specific deformation model equipped with personalized biomechanical parameters obtained from shear wave elastography to reliably predict the prostate deformation during image-guided interventions. Using data acquired from a prostate phantom and twelve patients with suspected prostate cancer, we compared the prostate deformation model with and without patient-specific biomechanical parameters in terms of deformation estimation accuracy. The results show that the patient-specific deformation model possesses favorable model ability, and outperforms the model without patient-specific biomechanical parameters. The employment of the patient-specific biomechanical parameters obtained from elastography for deformation modeling shows promise for providing more precise deformation estimation in applications that use computer-assisted image-guided intervention systems. PMID:27272239

  2. Evaluation of various deformable image registrations for point and volume variations

    NASA Astrophysics Data System (ADS)

    Han, Su Chul; Lee, Soon Sung; Kim, Mi-Sook; Ji, Young Hoon; Kim, Kum Bae; Choi, Sang Hyun; Park, Seungwoo; Jung, Haijo; Yoo, Hyung Jun; Yi, Chul Young

    2015-07-01

    The accuracy of deformable image registration (DIR) has a significant dosimetric impact in radiationtreatment planning. Many groups have studied the accuracy of DIR. In this study, we evaluatedthe accuracy of various DIR algorithms by using variations of the deformation point and volume.The reference image (I ref ) and volume (V ref ) were first generated by using virtual deformation QAsoftware (ImSimQA, Oncology System Limited, UK). We deformed I ref with axial movement of thedeformation point and V ref , depending on the type of deformation (relaxation and contraction) inImSimQA software. The deformed image (I def ) and volume (V def ) acquired by using the ImSimQAsoftware were inversely deformed relative to I ref and V ref by using DIR algorithms. As a result,we acquired a deformed image (I id ) from I def and volume (V id ) from V ref . Four intensity-basedalgorithms were tested by following the horn-schunk optical flow (HS), iterative optical flow (IOF),modified demons (MD) and fast demons (FD) with the Deformable Image Registration and AdaptiveRadiotherapy Toolkit (DIRART) of MATLAB. The image similarity between I ref and I id wascalculated to evaluate the accuracy of DIR algorithms using by Normalized Mutual Information(NMI) and Normalized Cross Correlation (NCC) metrics, when the distance of point deformationwas moved 4 mm, the value of NMI was above 1.81 and that of NCC was above 0.99 in all DIRalgorithms. As the degree of deformation was increased, the degree of image similarity decreased.When the V ref was increased or decreased by about 12%, the difference between V ref and V id waswithin ±5% regardless of the type of deformation, the deformation was classified into two types:deformation 1 increased the V ref (relaxation) and deformation 2 decreased the V ref (contraction).The value of the Dice Similarity Coefficient (DSC) was above 0.95 in deformation 1 except for theMD algorithm. In the case of deformation 2, the value of the DSC was above 0.95 in

  3. Surface deformation in Houston, Texas using GPS

    NASA Astrophysics Data System (ADS)

    Engelkemeir, Richard; Khan, Shuhab D.; Burke, Kevin

    2010-07-01

    Surface deformation in the Houston area has been quantified by using a variety of methods including LIDAR, InSAR, extensometers, drilling (to approximately 100 m), and Ground Penetrating Radar. In this paper we report on GPS data acquired during the period between 1995 and 2005 that found evidence of ongoing subsidence (up to - 56 mm/year) in northwestern Houston and of possible horizontal surface movement towards the Gulf of Mexico (up to 6 mm/year). We describe the methods of data-processing used in the study and speculate on the possibility that the active elevation of salt domes, mainly at the south and east of the city, may indirectly influence other surface movements including fault movements and subsidence over areas > 1 km 2. Making use of our observations and analysis could help in natural hazard mitigation in the Houston area and possibly also indicate approaches to surface subsidence study that might be used in other urban areas.

  4. Algorithmic deformation of matrix factorisations

    NASA Astrophysics Data System (ADS)

    Carqueville, Nils; Dowdy, Laura; Recknagel, Andreas

    2012-04-01

    Branes and defects in topological Landau-Ginzburg models are described by matrix factorisations. We revisit the problem of deforming them and discuss various deformation methods as well as their relations. We have implemented these algorithms and apply them to several examples. Apart from explicit results in concrete cases, this leads to a novel way to generate new matrix factorisations via nilpotent substitutions, and to criteria whether boundary obstructions can be lifted by bulk deformations.

  5. Optical dynamic deformation measurements at translucent materials.

    PubMed

    Philipp, Katrin; Koukourakis, Nektarios; Kuschmierz, Robert; Leithold, Christoph; Fischer, Andreas; Czarske, Jürgen

    2015-02-15

    Due to their high stiffness-to-weight ratio, glass fiber-reinforced polymers are an attractive material for rotors, e.g., in the aerospace industry. A fundamental understanding of the material behavior requires non-contact, in-situ dynamic deformation measurements. The high surface speeds and particularly the translucence of the material limit the usability of conventional optical measurement techniques. We demonstrate that the laser Doppler distance sensor provides a powerful and reliable tool for monitoring radial expansion at fast rotating translucent materials. We find that backscattering in material volume does not lead to secondary signals as surface scattering results in degradation of the measurement volume inside the translucent medium. This ensures that the acquired signal contains information of the rotor surface only, as long as the sample surface is rough enough. Dynamic deformation measurements of fast-rotating fiber-reinforced polymer composite rotors with surface speeds of more than 300 m/s underline the potential of the laser Doppler sensor.

  6. Shape and volume of craniofacial cavities in intentional skull deformations.

    PubMed

    Khonsari, R H; Friess, M; Nysjö, J; Odri, G; Malmberg, F; Nyström, I; Messo, E; Hirsch, J M; Cabanis, E A M; Kunzelmann, K H; Salagnac, J M; Corre, P; Ohazama, A; Sharpe, P T; Charlier, P; Olszewski, R

    2013-05-01

    Intentional cranial deformations (ICD) have been observed worldwide but are especially prevalent in preColombian cultures. The purpose of this study was to assess the consequences of ICD on three cranial cavities (intracranial cavity, orbits, and maxillary sinuses) and on cranial vault thickness, in order to screen for morphological changes due to the external constraints exerted by the deformation device. We acquired CT-scans for 39 deformed and 19 control skulls. We studied the thickness of the skull vault using qualitative and quantitative methods. We computed the volumes of the orbits, of the maxillary sinuses, and of the intracranial cavity using haptic-aided semi-automatic segmentation. We finally defined 3D distances and angles within orbits and maxillary sinuses based on 27 anatomical landmarks and measured these features on the 58 skulls. Our results show specific bone thickness patterns in some types of ICD, with localized thinning in regions subjected to increased pressure and thickening in other regions. Our findings confirm that volumes of the cranial cavities are not affected by ICDs but that the shapes of the orbits and of the maxillary sinuses are modified in circumferential deformations. We conclude that ICDs can modify the shape of the cranial cavities and the thickness of their walls but conserve their volumes. These results provide new insights into the morphological effects associated with ICDs and call for similar investigations in subjects with deformational plagiocephalies and craniosynostoses.

  7. Deformed chiral nucleons

    NASA Astrophysics Data System (ADS)

    Price, C. E.; Shepard, J. R.

    1991-04-01

    We compute properties of the nucleon in a hybrid chiral model based on the linear σ-model with quark degrees of freedom treated explicity. In contrast to previous calculations, we do not use the hedgehog ansatz. Instead we solve self-consistently for a state with well defined spin and isospin projections. We allow this state to be deformed and find that, although d- and g-state admixtures in the predominantly s-state single quark wave functions are not large, they have profound effects on many nucleon properties including magnetic moments and gA. Our best fit parameters provide excellent agreement with experiment but are much different from those determined in hedgehog calculations.

  8. [Rheumatic forefoot deformities].

    PubMed

    Fuhrmann, R

    2014-11-01

    The frequency and extent of rheumatic forefoot deformities have been greatly reduced since the introduction of disease-modifying antirheumatic drugs (DMARD). The accompanying reduction in arthritic destruction of joints opens up new treatment options whereby priority is given to joint preservation. This is true for the first middle foot ray as well as for the small toe rays. Whereas resection arthroplasty of the metatarsophalangeal joints II-V was previously considered the gold standard treatment, joint-preserving operative procedures (e.g. metatarsal osteotomy and periarticular soft tissue interventions) are now being increasingly more propagated. Resection arthroplasty of the first midfoot ray has major biomechanical disadvantages so that it is not surprising that reconstructive procedures are given priority. In patients with severe arthritic destruction of the first metatarsophalangeal joint, arthrodesis has substantial biomechanical advantages compared to resection arthroplasty. Nevertheless, it has not yet been confirmed that fusion leads to superior clinical results.

  9. A persistent scatterer interpolation for retrieving accurate ground deformation over InSAR-decorrelated agricultural fields

    NASA Astrophysics Data System (ADS)

    Chen, Jingyi; Zebker, Howard A.; Knight, Rosemary

    2015-11-01

    Interferometric synthetic aperture radar (InSAR) is a radar remote sensing technique for measuring surface deformation to millimeter-level accuracy at meter-scale resolution. Obtaining accurate deformation measurements in agricultural regions is difficult because the signal is often decorrelated due to vegetation growth. We present here a new algorithm for retrieving InSAR deformation measurements over areas with severe vegetation decorrelation using adaptive phase interpolation between persistent scatterer (PS) pixels, those points at which surface scattering properties do not change much over time and thus decorrelation artifacts are minimal. We apply this algorithm to L-band ALOS interferograms acquired over the San Luis Valley, Colorado, and the Tulare Basin, California. In both areas, the pumping of groundwater for irrigation results in deformation of the land that can be detected using InSAR. We show that the PS-based algorithm can significantly reduce the artifacts due to vegetation decorrelation while preserving the deformation signature.

  10. [Spectrum research on metamorphic and deformation of tectonically deformed coals].

    PubMed

    Li, Xiao-Shi; Ju, Yi-Wen; Hou, Quan-Lin; Lin, Hong

    2011-08-01

    The structural and compositive evolution of tectonically deformed coals (TDCs) and their influencing factors were investigated and analyzed in detail through Fourier transform infrared spectroscopy (FTIR) and laser Raman spectra analysis. The TDC samples (0.7% < Ro,max <3.1%) were collected from Huaibei coalfield with different deformation mechanisms and intensity. The FTIR of TDCs shows that the metamorphism and the deformation affect the degradation and polycondensation process of macromolecular structure to different degree. The Raman spectra analysis indicates that secondary structure defects can be produced mainly by structural deformation, also the metamorphism influences the secondary structure defects and aromatic structure. Through comprehensive analysis, it was discussed that the ductile deformation could change to strain energy through the increase and accumulation of dislocation in molecular structure units of TDC, and it could make an obvious influence on degradation and polycondensation. While the brittle deformation could change to frictional heat energy and promote the metamorphism and degradation of TDC structure, but has less effect on polycondensation. Furthermore, degradation is the main reason for affecting the structural evolution of coal in lower metamorphic stage, and polycondensation is the most important controlling factor in higher metamorphic stage. Under metamorphism and deformation, the small molecules which break and fall off from the macromolecular tructure of TDC are preferentially replenished and embedded into the secondary structure defects or the residual aromatic rings were formed into aromatic structure by polycondensation. This process improved the stability of coal structure. It is easier for ductile deformation of coal to induce the secondary structure defects than brittle deformation.

  11. [Hospital-acquired urinary tract infections].

    PubMed

    Adukauskiene, Dalia; Cicinskaite, Ilona; Vitkauskiene, Astra; Macas, Andrius; Tamosiūnas, Ramūnas; Kinderyte, Aida

    2006-01-01

    Urinary tract infections are responsible for 40-60% of all hospital-acquired infections. Increased age of patients and comorbid diseases render hospitalized patients more susceptible to infection. Almost 80% of hospital-acquired urinary tract infections are associated with urinary catheters, and only 5-10% of urinary infections are caused by invasive manipulations in the urogenital tract. Pathogens of hospital-acquired urinary tract infections are frequently multi-resistant, and antibiotic therapy can only be successful when the complicating factors are eliminated or urodynamic function is restored. For treatment of complicated hospital-acquired urinary tract infections, the antibiotics must exhibit adequate pharmacodynamic and pharmacokinetic properties: high renal clearance of unmetabolized form with good antimicrobial activity in both acidic and alkaline urine. For selection of empirical treatment of hospital-acquired urinary tract infections, it is necessary to evaluate localization of infection, its severity, possible isolates, and the most frequent pathogens in the department where patient is treated. The best choice for the starting the antimicrobial therapy is the cheapest narrow-spectrum effective antibiotic in the treatment of urinary tract infection until microbiological evaluation of pathogens will be received. Adequate management of urinary tract infections lowers the rate of complications, requirements for antibacterial treatment, selection of multi-resistant isolates and is cost effective.

  12. Perceptual transparency from image deformation

    PubMed Central

    Kawabe, Takahiro; Maruya, Kazushi; Nishida, Shin’ya

    2015-01-01

    Human vision has a remarkable ability to perceive two layers at the same retinal locations, a transparent layer in front of a background surface. Critical image cues to perceptual transparency, studied extensively in the past, are changes in luminance or color that could be caused by light absorptions and reflections by the front layer, but such image changes may not be clearly visible when the front layer consists of a pure transparent material such as water. Our daily experiences with transparent materials of this kind suggest that an alternative potential cue of visual transparency is image deformations of a background pattern caused by light refraction. Although previous studies have indicated that these image deformations, at least static ones, play little role in perceptual transparency, here we show that dynamic image deformations of the background pattern, which could be produced by light refraction on a moving liquid’s surface, can produce a vivid impression of a transparent liquid layer without the aid of any other visual cues as to the presence of a transparent layer. Furthermore, a transparent liquid layer perceptually emerges even from a randomly generated dynamic image deformation as long as it is similar to real liquid deformations in its spatiotemporal frequency profile. Our findings indicate that the brain can perceptually infer the presence of “invisible” transparent liquids by analyzing the spatiotemporal structure of dynamic image deformation, for which it uses a relatively simple computation that does not require high-level knowledge about the detailed physics of liquid deformation. PMID:26240313

  13. A simulation study of planar swaging deformation

    NASA Astrophysics Data System (ADS)

    Zhang, Cheng-Gen; Jen, Gwang-Shen; Su, Gwang-Huei

    1992-08-01

    Planar swaging deformation was studied with a photoplastic method. The domestic polycarbonate was used as a simulation material. The full-field strain distribution for planar swaging deformation was obtained. The average error of the calculated strain was less than 7 percent. The deformation area and the effect of friction on deformation area were studied with the characteristics of photoplasticity. This paper points out the special features of planar swaging deformation and the effect of lubrication on deformation flow.

  14. Femoral deformity planning: intentional placement of the apex of deformity.

    PubMed

    Fabricant, Peter D; Camara, James M; Rozbruch, S Robert

    2013-05-01

    Traditionally, correction of femoral deformity has been performed with osteotomies through the center of rotation of angulation (CORA), but the CORA location is not always practical. If the osteotomy is created at a site adjacent to the CORA, an additional translation must be performed to accurately correct the deformity. However, at times, the ideal osteotomy site may require an unfeasible amount of translation. Multiple osteotomies may also be problematic, and when overcorrection of the mechanical axis is planned, the CORA method is not practical.This article describes a novel method by which the surgeon may choose the location of the osteotomy regardless of the location of the CORA and may consolidate a multiapical deformity into a single corrective osteotomy. Furthermore, intentional mechanical axis overcorrection may be performed to unload knee joint arthritis. Simple, complex, and multiapical deformities may now be corrected via a single familiar surgical procedure, such as a distal femoral osteotomy, and the need for translation is eliminated.

  15. Videogrammetric Model Deformation Measurement Technique

    NASA Technical Reports Server (NTRS)

    Burner, A. W.; Liu, Tian-Shu

    2001-01-01

    The theory, methods, and applications of the videogrammetric model deformation (VMD) measurement technique used at NASA for wind tunnel testing are presented. The VMD technique, based on non-topographic photogrammetry, can determine static and dynamic aeroelastic deformation and attitude of a wind-tunnel model. Hardware of the system includes a video-rate CCD camera, a computer with an image acquisition frame grabber board, illumination lights, and retroreflective or painted targets on a wind tunnel model. Custom software includes routines for image acquisition, target-tracking/identification, target centroid calculation, camera calibration, and deformation calculations. Applications of the VMD technique at five large NASA wind tunnels are discussed.

  16. Control of micromachined deformable mirrors

    NASA Technical Reports Server (NTRS)

    Agronin, M. L.; Bartman, R.; Hadaegh, F. Y.; Kaiser, W.; Wang, P. K. C.

    1993-01-01

    A micromachined deformable mirror with pixelated electrostatic actuators is proposed. The paper begins with a physical description of the proposed mirror. Then a mathematical model in the form of a nonlinear partial differential equation describing the mirror surface deformations is derived. This model is used to derive the required voltages for the actuators to achieve a specified static deformation of the mirror surface. This is followed by the derivation of a static nonlinear feedback controller for achieving noninteracting actuation. Then the structure for a complete control system for wavefront correction is proposed. The paper concludes with a discussion of the physical implementation of the proposed control system.

  17. Cost of hospital-acquired infection.

    PubMed

    Hassan, Mahmud; Tuckman, Howard P; Patrick, Robert H; Kountz, David S; Kohn, Jennifer L

    2010-01-01

    The authors assessed the costs of hospital-acquired infections using rigorous econometric methods on publicly available data, controlling for the interdependency of length of stay and the incidence of hospital acquired infection, and estimated the cost shares of different payers. They developed a system of equations involving length of stay, incidence of infection, and the total hospital care cost to be estimated using simultaneous equations system. The main data came from the State of New Jersey UB 92 for 2004, complimented with data from the Annual Survey of Hospitals by the American Hospital Association and the Medicare Cost Report of 2004. The authors estimated that an incidence of hospital acquired infection increases the hospital care cost of a patient by $10,375 and it increases the length of stay by 3.30 days, and that a disproportionately higher portion of the cost is attributable to Medicare. They conclude that reliable cost estimates of hospital-acquired infections can be made using publicly available data. Their estimate shows a much larger aggregate cost of $16.6 billion as opposed to $5 billion reported by the Centers for Disease Control and Prevention but much less than $29 billion as reported elsewhere in the literature.

  18. 7 CFR 989.17 - Acquire.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Acquire. 989.17 Section 989.17 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE RAISINS PRODUCED FROM GRAPES GROWN...

  19. How Did Light Acquire a Velocity?

    ERIC Educational Resources Information Center

    Lauginie, Pierre

    2013-01-01

    We discuss how light acquired a velocity through history, from the ancient Greeks to the early modern era. Combining abstract debates, models of light, practical needs, planned research and chance, this history illustrates several key points that should be brought out in science education.

  20. Sexually acquired Salmonella Typhi urinary tract infection.

    PubMed

    Wielding, Sally; Scott, Gordon

    2016-05-01

    We report a case of isolated urinary Salmonella enterica serotype Typhi in an HIV-positive man who has sex with men. He was clinically well and blood and stool cultures were negative, indicating that this may have been a sexually acquired urinary tract infection.

  1. 7 CFR 989.17 - Acquire.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Acquire. 989.17 Section 989.17 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE RAISINS PRODUCED FROM GRAPES GROWN...

  2. 7 CFR 989.17 - Acquire.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Acquire. 989.17 Section 989.17 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE RAISINS PRODUCED FROM GRAPES GROWN...

  3. 7 CFR 989.17 - Acquire.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Acquire. 989.17 Section 989.17 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE RAISINS PRODUCED FROM GRAPES GROWN...

  4. 7 CFR 989.17 - Acquire.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Acquire. 989.17 Section 989.17 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE RAISINS PRODUCED FROM GRAPES GROWN...

  5. Eye Movement Correlates of Acquired Central Dyslexia

    ERIC Educational Resources Information Center

    Schattka, Kerstin I.; Radach, Ralph; Huber, Walter

    2010-01-01

    Based on recent progress in theory and measurement techniques, the analysis of eye movements has become one of the major methodological tools in experimental reading research. Our work uses this approach to advance the understanding of impaired information processing in acquired central dyslexia of stroke patients with aphasia. Up to now there has…

  6. Group Treatment in Acquired Brain Injury Rehabilitation

    ERIC Educational Resources Information Center

    Bertisch, Hilary; Rath, Joseph F.; Langenbahn, Donna M.; Sherr, Rose Lynn; Diller, Leonard

    2011-01-01

    The current article describes critical issues in adapting traditional group-treatment methods for working with individuals with reduced cognitive capacity secondary to acquired brain injury. Using the classification system based on functional ability developed at the NYU Rusk Institute of Rehabilitation Medicine (RIRM), we delineate the cognitive…

  7. Acquiring a Second Language for School.

    ERIC Educational Resources Information Center

    Collier, Virginia P.

    1995-01-01

    This report offers a conceptual model for use with language minority children who are entering a new school when they must acquire the language of the majority student population. The model has four development components or processes: sociocultural, linguistic, academic, and cognitive. These four components are described in detail. Research is…

  8. Acquired immunodeficiency syndrome with subacute sclerosing panencephalitis.

    PubMed

    Gowda, Vykuntaraju K N; Sukanya, V; Shivananda

    2012-11-01

    A 7-year-old boy with acquired immunodeficiency syndrome, receiving antiretroviral drugs for 2 years, presented with a recent onset of myoclonic jerks and cognitive deterioration. On examination, he manifested myoclonic jerks once every 10-15 seconds. His electroencephalogram indicated periodic complexes, and his cerebrospinal fluid tested positive for measles antibodies.

  9. WE-G-BRF-01: Adaptation to Intrafraction Tumor Deformation During Intensity-Modulated Radiotherapy: First Proof-Of-Principle Demonstration

    SciTech Connect

    Ge, Y; OBrien, R; Shieh, C; Booth, J; Keall, P

    2014-06-15

    Purpose: Intrafraction tumor deformation limits targeting accuracy in radiotherapy and cannot be adapted to by current motion management techniques. This study simulated intrafractional treatment adaptation to tumor deformations using a dynamic Multi-Leaf Collimator (DMLC) tracking system during Intensity-modulated radiation therapy (IMRT) treatment for the first time. Methods: The DMLC tracking system was developed to adapt to the intrafraction tumor deformation by warping the planned beam aperture guided by the calculated deformation vector field (DVF) obtained from deformable image registration (DIR) at the time of treatment delivery. Seven single phantom deformation images up to 10.4 mm deformation and eight tumor system phantom deformation images up to 21.5 mm deformation were acquired and used in tracking simulation. The intrafraction adaptation was simulated at the DMLC tracking software platform, which was able to communicate with the image registration software, reshape the instantaneous IMRT field aperture and log the delivered MLC fields.The deformation adaptation accuracy was evaluated by a geometric target coverage metric defined as the sum of the area incorrectly outside and inside the reference aperture. The incremental deformations were arbitrarily determined to take place equally over the delivery interval. The geometric target coverage of delivery with deformation adaptation was compared against the delivery without adaptation. Results: Intrafraction deformation adaptation during dynamic IMRT plan delivery was simulated for single and system deformable phantoms. For the two particular delivery situations, over the treatment course, deformation adaptation improved the target coverage by 89% for single target deformation and 79% for tumor system deformation compared with no-tracking delivery. Conclusion: This work demonstrated the principle of real-time tumor deformation tracking using a DMLC. This is the first step towards the development of an

  10. Image updating for brain deformation compensation in tumor resection

    NASA Astrophysics Data System (ADS)

    Fan, Xiaoyao; Ji, Songbai; Olson, Jonathan D.; Roberts, David W.; Hartov, Alex; Paulsen, Keith D.

    2016-03-01

    Preoperative magnetic resonance images (pMR) are typically used for intraoperative guidance in image-guided neurosurgery, the accuracy of which can be significantly compromised by brain deformation. Biomechanical finite element models (FEM) have been developed to estimate whole-brain deformation and produce model-updated MR (uMR) that compensates for brain deformation at different surgical stages. Early stages of surgery, such as after craniotomy and after dural opening, have been well studied, whereas later stages after tumor resection begins remain challenging. In this paper, we present a method to simulate tumor resection by incorporating data from intraoperative stereovision (iSV). The amount of tissue resection was estimated from iSV using a "trial-and-error" approach, and the cortical shift was measured from iSV through a surface registration method using projected images and an optical flow (OF) motion tracking algorithm. The measured displacements were employed to drive the biomechanical brain deformation model, and the estimated whole-brain deformation was subsequently used to deform pMR and produce uMR. We illustrate the method using one patient example. The results show that the uMR aligned well with iSV and the overall misfit between model estimates and measured displacements was 1.46 mm. The overall computational time was ~5 min, including iSV image acquisition after resection, surface registration, modeling, and image warping, with minimal interruption to the surgical flow. Furthermore, we compare uMR against intraoperative MR (iMR) that was acquired following iSV acquisition.

  11. Variable focal length deformable mirror

    DOEpatents

    Headley, Daniel; Ramsey, Marc; Schwarz, Jens

    2007-06-12

    A variable focal length deformable mirror has an inner ring and an outer ring that simply support and push axially on opposite sides of a mirror plate. The resulting variable clamping force deforms the mirror plate to provide a parabolic mirror shape. The rings are parallel planar sections of a single paraboloid and can provide an on-axis focus, if the rings are circular, or an off-axis focus, if the rings are elliptical. The focal length of the deformable mirror can be varied by changing the variable clamping force. The deformable mirror can generally be used in any application requiring the focusing or defocusing of light, including with both coherent and incoherent light sources.

  12. ROCK DEFORMATION. Final Progress Report

    SciTech Connect

    2002-05-24

    The Gordon Research Conference (GRC) on ROCK DEFORMATION was held at II Ciocco from 5/19/02 thru 5/24/02. Emphasis was placed on current unpublished research and discussion of the future target areas in this field.

  13. Deformity of Ears and Kidneys

    PubMed Central

    Taylor, W. C.

    1965-01-01

    Ten children with gross deformity of the external ear were observed. In six the facial bones were underdeveloped on the same side as the deformed ear. In all six there was a congenital abnormality of the kidney or upper urinary tract, usually on the same side as the deformed ear. In addition there were usually other associated congenital defects in each case. In the remaining four children the facial bones appeared normal, and pyelography showed no abnormality of the urinary tract. In these four children there were no other associated defects. These observations emphasize the importance of investigating the urinary tract in children with gross deformity of the external ear, especially where there is an associated underdevelopment of the facial bones. PMID:14317453

  14. Anisotropic ripple deformation in phosphorene

    DOE PAGES

    Kou, Liangzhi; Ma, Yandong; Smith, Sean C.; ...

    2015-04-07

    Here, two-dimensional materials tend to become crumpled according to the Mermin-Wagner theorem, and the resulting ripple deformation may significantly influence electronic properties as observed in graphene and MoS2. Here, we unveil by first-principles calculations a new, highly anisotropic ripple pattern in phosphorene, a monolayer black phosphorus, where compression-induced ripple deformation occurs only along the zigzag direction in the strain range up to 10%, but not the armchair direction. This direction-selective ripple deformation mode in phosphorene stems from its puckered structure with coupled hinge-like bonding configurations and the resulting anisotropic Poisson ratio. We also construct an analytical model using classical elasticitymore » theory for ripple deformation in phosphorene under arbitrary strain. The present results offer new insights into the mechanisms governing the structural and electronic properties of phosphorene crucial to its device applications.« less

  15. Anisotropic ripple deformation in phosphorene

    SciTech Connect

    Kou, Liangzhi; Ma, Yandong; Smith, Sean C.; Chen, Changfeng

    2015-04-07

    Here, two-dimensional materials tend to become crumpled according to the Mermin-Wagner theorem, and the resulting ripple deformation may significantly influence electronic properties as observed in graphene and MoS2. Here, we unveil by first-principles calculations a new, highly anisotropic ripple pattern in phosphorene, a monolayer black phosphorus, where compression-induced ripple deformation occurs only along the zigzag direction in the strain range up to 10%, but not the armchair direction. This direction-selective ripple deformation mode in phosphorene stems from its puckered structure with coupled hinge-like bonding configurations and the resulting anisotropic Poisson ratio. We also construct an analytical model using classical elasticity theory for ripple deformation in phosphorene under arbitrary strain. The present results offer new insights into the mechanisms governing the structural and electronic properties of phosphorene crucial to its device applications.

  16. Anisotropic Ripple Deformation in Phosphorene.

    PubMed

    Kou, Liangzhi; Ma, Yandong; Smith, Sean C; Chen, Changfeng

    2015-05-07

    Two-dimensional materials tend to become crumpled according to the Mermin-Wagner theorem, and the resulting ripple deformation may significantly influence electronic properties as observed in graphene and MoS2. Here, we unveil by first-principles calculations a new, highly anisotropic ripple pattern in phosphorene, a monolayer black phosphorus, where compression-induced ripple deformation occurs only along the zigzag direction in the strain range up to 10%, but not the armchair direction. This direction-selective ripple deformation mode in phosphorene stems from its puckered structure with coupled hinge-like bonding configurations and the resulting anisotropic Poisson ratio. We also construct an analytical model using classical elasticity theory for ripple deformation in phosphorene under arbitrary strain. The present results offer new insights into the mechanisms governing the structural and electronic properties of phosphorene crucial to its device applications.

  17. Plastic Deformation of Granular Materials

    DTIC Science & Technology

    1993-01-25

    discontinuities. These result will be important in our granular flow work, when considering viscoplastic constitutive relations (i.e. relaxation systems...5 CUNDN( NUMRES Plastic Deformation of Granular Materials (U) 61102F 6. AUTHOR(S) 2304/A4 Dr. E. Bruce Pitman 7 PERFORMING ORGANIZATION NA .h • 8...lose hyperbolicity. 98 3 81 061! SUBJECT TERMS 15. NUMBER OF PAGES granular material ; plastic deformation; hyperbolic 12 equations 16. PRICE CODE 17

  18. Cleft Nasal Deformity and Rhinoplasty

    PubMed Central

    Kaufman, Yoav; Buchanan, Edward P.; Wolfswinkel, Erik M.; Weathers, William M.; Stal, Samuel

    2012-01-01

    The cleft nasal deformity is a complex challenge in plastic surgery involving the skin, cartilage, mucosa, and skeletal platform. Ever since Blair and Brown first described the intricacies of the cleft pathology in 1931, the appropriate approach has been extensively debated in the literature with respect to timing, technique, and extent of surgical intervention. In this article, the authors review the literature and summarize the various modalities for achieving a successful rhinoplasty in the patient with a cleft nasal deformity. PMID:24179452

  19. Treatment of acquired nasopharyngeal stenosis using a removable silicone stent.

    PubMed

    De Lorenzi, Davide; Bertoncello, Diana; Comastri, Stefano; Bottero, Enrico

    2015-02-01

    The aim of this prospective study was to characterise patient characteristics and the histories of cats with acquired nasopharyngeal stenosis (ANS), and to describe the use of a removable silicone stent for treatment. ANS was diagnosed in 15 cats with clinical signs present for a median of 4 months. Clinical signs included stertor and inspiratory difficulty, nasal discharge, sneezing, dysphagia, regurgitation, vomiting and anorexia. Radiographs revealed a dorsal deviation or deformation of the caudal part of the soft palate in 10 of the cats, a soft tissue density across the cranial nasopharynx in four and no abnormality in one. The stenosis was initially dilated with a Kelly forceps in 10 of the cats and by balloon dilatation in five. A segment of a 24 Fr silicone thoracic catheter was used for the stent in five cats; in the other 10 cats a segment of a 28 Fr catheter was used. The stent was removed after 3 weeks in 12 cats and after 4 weeks in the other three. Endoscopy revealed an adequate nasopharyngeal diameter in all of the cats. At both 3 and 10 months after surgery the response was considered to be satisfactory, with complete resolution of clinical signs in 14 cats and improvement in the remaining cat. The treatment of ANS by stenosis dilatation followed by temporary stenting with a silicone stent is a rapid, safe, economical and effective procedure.

  20. Correcting peak deformation in Rosetta's ROSINA/DFMS mass spectrometer

    NASA Astrophysics Data System (ADS)

    De Keyser, Johan; Dhooghe, Frederik; Gibbons, Andrew; Altwegg, Kathrin; Balsiger, Hans; Berthelier, Jean-Jacques; Briois, Christelle; Calmonte, Ursina; Cessateur, Gaël; Equeter, Eddy; Fiethe, Björn; Fuselier, Stephen; Gombosi, Tamas; Gunell, Herbert; Hässig, Myrttha; Le Roy, Léna; Maggiolo, Romain; Neefs, Eddy; Rubin, Martin; Sémon, Thierry

    2016-04-01

    The Double Focusing Mass Spectrometer (DFMS), part of the ROSINA instrument package aboard the European Space Agency's Rosetta spacecraft visiting comet 67P/Churyumov-Gerasimenko, experiences minor deformation of the mass peaks in the high resolution spectra acquired for m/Z = 16, 17, and to a lesser extent 18. A numerical deconvolution technique has been developed with a two-fold purpose. A first goal is to verify whether the most likely cause of the issue, a lack of stability of one of the electric potentials in the electrostatic analyser, can indeed be held responsible for it. The second goal is to correct for the deformation, in view of the important species located around these masses, and to allow a standard further treatment of the spectra in the automated DFMS data processing chain.

  1. Microstructure-strength relationship of a deformation processed aluminum-titanium composite

    SciTech Connect

    Lund, T.

    1998-02-23

    The mechanical properties, electrical properties and microstructures have been evaluated for an Al-20 wt % Ti deformation processed metal metal matrix composite (DMMC). The strength of the swaged, extruded and wire drawn composite increases several-fold with increasing deformation up to a true strain of 12.1, the maximum investigated. At this point the Ti was elongated and SEM and TEM analysis of the transverse direction of the wire showed the ribbon-like filaments that are common for this type of material. Texture development was also characterized to explain the deformation characteristics of the composite materials. The Ti filaments acquired a <10{bar 1}0> fiber texture during deformation, and the Al filaments acquired a dual texture of (111) and (100). Resistivity measurements of the composite showed that for the highest deformed sample ({eta} = 12.1), the resistivity increased linearly with temperature up to the temperature where Al{sub 3}Ti formed. At this point the slope increased. Beyond this point, the resistivity of the sample never returned to its original value. The temperature where Al{sub 3}Ti forms was investigated using DTA and XRD analysis. The reaction temperature decreases with increasing deformation true strain ({eta}) and filament spacing.

  2. Analysis of Mining Terrain Deformation Characteristics with Deformation Information System

    NASA Astrophysics Data System (ADS)

    Blachowski, Jan; Milczarek, Wojciech; Grzempowski, Piotr

    2014-05-01

    Mapping and prediction of mining related deformations of the earth surface is an important measure for minimising threat to surface infrastructure, human population, the environment and safety of the mining operation itself arising from underground extraction of useful minerals. The number of methods and techniques used for monitoring and analysis of mining terrain deformations is wide and increasing with the development of geographical information technologies. These include for example: terrestrial geodetic measurements, global positioning systems, remote sensing, spatial interpolation, finite element method modelling, GIS based modelling, geological modelling, empirical modelling using the Knothe theory, artificial neural networks, fuzzy logic calculations and other. The aim of this paper is to introduce the concept of an integrated Deformation Information System (DIS) developed in geographic information systems environment for analysis and modelling of various spatial data related to mining activity and demonstrate its applications for mapping and visualising, as well as identifying possible mining terrain deformation areas with various spatial modelling methods. The DIS concept is based on connected modules that include: the spatial database - the core of the system, the spatial data collection module formed by: terrestrial, satellite and remote sensing measurements of the ground changes, the spatial data mining module for data discovery and extraction, the geological modelling module, the spatial data modeling module with data processing algorithms for spatio-temporal analysis and mapping of mining deformations and their characteristics (e.g. deformation parameters: tilt, curvature and horizontal strain), the multivariate spatial data classification module and the visualization module allowing two-dimensional interactive and static mapping and three-dimensional visualizations of mining ground characteristics. The Systems's functionality has been presented on

  3. Preferred orientation in experimentally deformed stishovite: implications for deformation mechanisms

    NASA Astrophysics Data System (ADS)

    Kaercher, P. M.; Zepeda-Alarcon, E.; Prakapenka, V.; Kanitpanyacharoen, W.; Smith, J.; Sinogeikin, S. V.; Wenk, H. R.

    2014-12-01

    The crystal structure of the high pressure SiO2 polymorph stishovite has been studied in detail, yet little is known about its deformation mechanisms. Information about how stishovite deforms under stress is important for understanding subduction of quartz-bearing crustal rocks into the mantle. Particularly, stishovite is elastically anisotropic and thus development of crystallographic preferred orientation (CPO) during deformation may contribute to seismic anomalies in the mantle. We converted a natural sample of flint to stishovite in a laser heated diamond anvil cell and compressed the stishovite aggregate up to 38 GPa. Diffraction patterns were collected in situ in radial geometry at the Advanced Light Source (ALS) and the Advanced Photon Source (APS) to examine development of CPO during deformation. We find that (001) poles preferentially align with the compression direction and infer deformation mechanisms leading to the observed CPO with visco-plastic self consistent (VPSC) polycrystal plasticity models. Our results show pyramidal and basal slip are most likely active at high pressure and ambient temperature, in agreement with transmission electron microscopy (TEM) studies of rutile (TiO2) and paratellurite (TeO2), which are isostructural to stishovite. Conversely other TEM studies of stishovite done at higher temperature suggest dominant prismatic slip. This indicates that a variety of slip systems may be active in stishovite, depending on conditions. As a result, stishovite's contribution to the seismic signature in the mantle may vary as a function of pressure and temperature and thus depth.

  4. [Acquired paraneoplastic hypertrichosis lanuginosa associated with scleroderma].

    PubMed

    Valda Rodriguez, L; Torrico Velasco, J; Zeballos Vasconcellos, R

    1990-01-01

    Acquired hypertrichosis lanuginosa is universally recognized as an individual disease and seldom reported as a genuine paraneoplastic manifestation. We report the case of a 30-year old woman with acquired hypertrichosis lanuginosa. Due to the finding of a cervical lymph node metastasis, she was investigated for an internal neoplasm, but the original tumour could not be found by the usual methods. A bronchogenic carcinoma was discovered at autopsy. Beside hypertrichosis, this patient had other disorders not described in the literature as associated with that disease, viz.: progressive systemic scleroderma, fissured and hyperpigmented tongue, thrombocytopenia, galactorrhoea, axillary and pubic alopecia and overcurvature of toe nails. A review of similar cases in the literature provided clinical arguments in favour of the hormonal origin of this paraneoplastic hypertrichosis.

  5. Acquired portosystemic collaterals: anatomy and imaging.

    PubMed

    Leite, Andréa Farias de Melo; Mota, Américo; Chagas-Neto, Francisco Abaeté; Teixeira, Sara Reis; Elias Junior, Jorge; Muglia, Valdair Francisco

    2016-01-01

    Portosystemic shunts are enlarged vessels that form collateral pathological pathways between the splanchnic circulation and the systemic circulation. Although their causes are multifactorial, portosystemic shunts all have one mechanism in common-increased portal venous pressure, which diverts the blood flow from the gastrointestinal tract to the systemic circulation. Congenital and acquired collateral pathways have both been described in the literature. The aim of this pictorial essay was to discuss the distinct anatomic and imaging features of portosystemic shunts, as well as to provide a robust method of differentiating between acquired portosystemic shunts and similar pathologies, through the use of illustrations and schematic drawings. Imaging of portosystemic shunts provides subclinical markers of increased portal venous pressure. Therefore, radiologists play a crucial role in the identification of portosystemic shunts. Early detection of portosystemic shunts can allow ample time to perform endovascular shunt operations, which can relieve portal hypertension and prevent acute or chronic complications in at-risk patient populations.

  6. Clinical laboratory data: acquire, analyze, communicate, liberate.

    PubMed

    Azzazy, Hassan M E; Elbehery, Ali H A

    2015-01-01

    The availability of portable healthcare devices, which can acquire and transmit medical data to remote experts would dramatically affect healthcare in areas with poor infrastructure. Smartphones, which feature touchscreen computer capabilities and sophisticated cameras, have become widely available with over billion units shipped in 2013. In the clinical laboratory, smartphones have recently brought the capabilities of key instruments such as spectrophotometers, fluorescence analyzers and microscopes into the palm of the hand. Several research groups have developed sensitive and low-cost smartphone-based diagnostic assay prototypes for testing cholesterol, albumin, vitamin D, tumor markers, and the detection of infectious agents. This review covers the use of smartphones to acquire, analyze, communicate, and liberate clinical laboratory data. Smartphones promise to dramatically improve the quality and quantity of healthcare offered in resource-limited areas.

  7. Subcortical infarction resulting in acquired stuttering.

    PubMed

    Ciabarra, A M; Elkind, M S; Roberts, J K; Marshall, R S

    2000-10-01

    Stuttering is an uncommon presentation of acute stroke. Reported cases have often been associated with left sided cortical lesions, aphasia, and difficulties with other non-linguistic tests of rhythmic motor control. Three patients with subcortical lesions resulting in stuttering are discussed. In one patient the ability to perform time estimations with a computerised repetitive time estimation task was characterised. One patient had a pontine infarct with clinical evidence of cerebellar dysfunction. A second patient had a left basal ganglionic infarct and a disruption of timing estimation. A third patient had a left subcortical infarct and a mild aphasia. These findings expand the reported distribution of infarction that can result in acquired stuttering. Subcortical mechanisms of speech control and timing may contribute to the pathophysiology of acquired stuttering.

  8. Recognising and managing community-acquired pneumonia.

    PubMed

    Gibson, Vanessa

    2015-11-18

    Pneumonia remains a significant cause of morbidity and mortality in the UK and yet the seriousness of the disease is underestimated. Pneumonia can be life-threatening because the delicate tissues of the alveoli and pulmonary capillaries are susceptible to damage from the inflammatory response. This damage leads to consolidation that prevents the diffusion of oxygen and carbon dioxide, and this in turn can lead to respiratory failure. This article summarises guidance on the diagnosis and management of community-acquired pneumonia, and also includes information on the prevention of pneumonia. This information should be valuable to nurses working in a variety of clinical areas since patients with community-acquired pneumonia are encountered in primary, intermediate, secondary and critical care.

  9. Acquired versus familial demyelinative neuropathies in children.

    PubMed

    Miller, R G; Gutmann, L; Lewis, R A; Sumner, A J

    1985-01-01

    The electrophysiologic differences between chronic acquired demyelinative neuropathy and the demyelinative form of Charcot-Marie-Tooth disease have recently been reported. The present report extends these observations to include the genetically determined demyelinating neuropathies seen in metachromatic leukodystrophy, Krabbe's leukodystrophy, and Cockayne's syndrome. The electrophysiologic features of metachromatic leukodystrophy (five patients), Krabbe's (four patients), and Cockayne's syndrome (three patients) were all similar. There was uniform slowing of conduction (both in different nerves and in different nerve segments), and conduction block was not seen. These findings are consistent with a uniform degree of demyelination in multiple nerves and throughout the entire length of individual axons. Thus, uniform slowing of nerve conduction constitutes strong evidence for a familial demyelinative neuropathy, as opposed to the multifocal slowing seen in acute and chronic acquired demyelinative neuropathy.

  10. Acquired portosystemic collaterals: anatomy and imaging*

    PubMed Central

    Leite, Andréa Farias de Melo; Mota Jr., Américo; Chagas-Neto, Francisco Abaeté; Teixeira, Sara Reis; Elias Junior, Jorge; Muglia, Valdair Francisco

    2016-01-01

    Portosystemic shunts are enlarged vessels that form collateral pathological pathways between the splanchnic circulation and the systemic circulation. Although their causes are multifactorial, portosystemic shunts all have one mechanism in common-increased portal venous pressure, which diverts the blood flow from the gastrointestinal tract to the systemic circulation. Congenital and acquired collateral pathways have both been described in the literature. The aim of this pictorial essay was to discuss the distinct anatomic and imaging features of portosystemic shunts, as well as to provide a robust method of differentiating between acquired portosystemic shunts and similar pathologies, through the use of illustrations and schematic drawings. Imaging of portosystemic shunts provides subclinical markers of increased portal venous pressure. Therefore, radiologists play a crucial role in the identification of portosystemic shunts. Early detection of portosystemic shunts can allow ample time to perform endovascular shunt operations, which can relieve portal hypertension and prevent acute or chronic complications in at-risk patient populations. PMID:27777479

  11. Finite deformation analysis of geomaterials

    NASA Astrophysics Data System (ADS)

    Jeremi, Boris; Runesson, Kenneth; Sture, Stein

    2001-07-01

    The mathematical structure and numerical analysis of classical small deformation elasto-plasticity is generally well established. However, development of large deformation elastic-plastic numerical formulation for dilatant, pressure sensitive material models is still a research area.In this paper we present development of the finite element formulation and implementation for large deformation, elastic-plastic analysis of geomaterials. Our developments are based on the multiplicative decomposition of the deformation gradient into elastic and plastic parts. A consistent linearization of the right deformation tensor together with the Newton method at the constitutive and global levels leads toward an efficient and robust numerical algorithm. The presented numerical formulation is capable of accurately modelling dilatant, pressure sensitive isotropic and anisotropic geomaterials subjected to large deformations. In particular, the formulation is capable of simulating the behaviour of geomaterials in which eigentriads of stress and strain do not coincide during the loading process.The algorithm is tested in conjunction with the novel hyperelasto-plastic model termed the B material model, which is a single surface (single yield surface, affine single ultimate surface and affine single potential surface) model for dilatant, pressure sensitive, hardening and softening geomaterials. It is specifically developed to model large deformation hyperelasto-plastic problems in geomechanics.We present an application of this formulation to numerical analysis of low confinement tests on cohesionless granular soil specimens recently performed in a SPACEHAB module aboard the Space Shuttle during the STS-89 mission. We compare numerical modelling with test results and show the significance of added confinement by the thin hyperelastic latex membrane undergoing large stretching.

  12. Bilateral cleft lip nasal deformity

    PubMed Central

    Singh, Arun Kumar; Nandini, R.

    2009-01-01

    Bilateral cleft lip nose deformity is a multi-factorial and complex deformity which tends to aggravate with growth of the child, if not attended surgically. The goals of primary bilateral cleft lip nose surgery are, closure of the nasal floor and sill, lengthening of the columella, repositioning of the alar base, achieving nasal tip projection, repositioning of the lower lateral cartilages, and reorienting the nares from horizontal to oblique position. The multiplicity of procedures in the literature for correction of this deformity alludes to the fact that no single procedure is entirely effective. The timing for surgical intervention and its extent varies considerably. Early surgery on cartilage may adversely affect growth and development; at the same time, allowing the cartilage to grow in an abnormal position and contributing to aggravation of deformity. Some surgeons advocate correction of deformity at an early age. However, others like the cartilages to grow and mature before going in for surgery. With peer pressure also becoming an important consideration during the teens, the current trend is towards early intervention. There is no unanimity in the extent of nasal dissection to be done at the time of primary lip repair. While many perform limited nasal dissection for the fear of growth retardation, others opt for full cartilage correction at the time of primary surgery itself. The value of naso-alveolar moulding (NAM) too is not universally accepted and has now more opponents than proponents. Also most centres in the developing world have neither the personnel nor the facilities for the same. The secondary cleft nasal deformity is variable and is affected by the extent of the original abnormality, any prior surgeries performed and alteration due to nasal growth. This article reviews the currently popular methods for correction of nasal deformity associated with bilateral cleft lip, it's management both at the time of cleft lip repair and also secondarily

  13. Deformation of second and third quantization

    NASA Astrophysics Data System (ADS)

    Faizal, Mir

    2015-03-01

    In this paper, we will deform the second and third quantized theories by deforming the canonical commutation relations in such a way that they become consistent with the generalized uncertainty principle. Thus, we will first deform the second quantized commutator and obtain a deformed version of the Wheeler-DeWitt equation. Then we will further deform the third quantized theory by deforming the third quantized canonical commutation relation. This way we will obtain a deformed version of the third quantized theory for the multiverse.

  14. Brucella abortus Infection Acquired in Microbiology Laboratories

    PubMed Central

    Fiori, Pier Luigi; Mastrandrea, Scilla; Rappelli, Paola; Cappuccinelli, Piero

    2000-01-01

    We report an outbreak of laboratory-acquired Brucella abortus infection originating in the accidental breakage of a centrifuge tube. A total of 12 laboratory workers were infected (attack rate of 31%), with an incubation time ranging from 6 weeks to 5 months. Antibody titers were evaluated weekly in all personnel exposed, allowing the diagnosis of the infection in most cases before the onset of clinical symptoms, so that specific therapy could be administrated. PMID:10790142

  15. Acquiring Secure Systems Through Information Economics

    DTIC Science & Technology

    2015-05-01

    Introduction “For all future weapons systems that DoD will acquire or procure, DoD will mandate specific cybersecurity standards for weapons...systems to meet. Acquisition and procurement policy and practice will be updated to promote effective cybersecurity throughout a system’s life cycle...physical damage or injury Motivating Contractor Efforts - Contractors have different priorities than the DOD when it comes to cybersecurity - Classic

  16. Earth Knowledge Acquired by Middle School Students

    NASA Technical Reports Server (NTRS)

    Ride, Sally

    2008-01-01

    Earth Knowledge Acquired by Middle School Students (EarthKAM), an education activity, allows middle school students to program a digital camera on board the International Space Station to photograph a variety of geographical targets for study in the classroom. Photos are made available on the web for viewing and study by participating schools around the world. Educators use the images for projects involving Earth Science, geography, physics, and social science.

  17. Acquired Antibiotic Resistance Genes: An Overview

    PubMed Central

    van Hoek, Angela H. A. M.; Mevius, Dik; Guerra, Beatriz; Mullany, Peter; Roberts, Adam Paul; Aarts, Henk J. M.

    2011-01-01

    In this review an overview is given on antibiotic resistance (AR) mechanisms with special attentions to the AR genes described so far preceded by a short introduction on the discovery and mode of action of the different classes of antibiotics. As this review is only dealing with acquired resistance, attention is also paid to mobile genetic elements such as plasmids, transposons, and integrons, which are associated with AR genes, and involved in the dispersal of antimicrobial determinants between different bacteria. PMID:22046172

  18. Acquired ciliary circumscribed grey hair (ACCG).

    PubMed

    Romero, A G; Calatayud, J C

    2001-12-01

    Grey-haired areas usually occur due to aging or inheritance. A case is described of abrupt occurrence of a focal circumscribed grey-hair in the eyebrow region (a single hair) in a 27-year-old woman. The phenomenon was named acquired ciliary circumscribed grey-hair (ACCG). Qualitative and semiquantitative findings were obtained by microanalytical studies. In addition to morphological differences from control hair, the ACCG hair showed a high percentage of sulfur (99.8%) and absence of oligoelements.

  19. Rare presentation of spontaneous acquired diaphragmatic hernia.

    PubMed

    Gupta, Shweta; Bali, Roseleen Kaur; Das, Kamanasish; Sisodia, Anula; Dewan, R K; Singla, Rupak

    2011-01-01

    Spontaneous acquired diaphragmatic hernia without any apparent history of trauma is a very rare condition and is very difficult to diagnose. We present a case of a 21-year-old male who presented with abdominal pain for one month and four episodes of vomiting for one day. Clinical suspicion, chest radiography with nasogastric tube in situ and computed tomography (CT) confirmed the diagnosis. The diaphragmatic defect was repaired surgically. The patient had an uneventful post-operative recovery.

  20. The pathophysiology of acquired premature ejaculation.

    PubMed

    McMahon, Chris G; Jannini, Emmanuele A; Serefoglu, Ege C; Hellstrom, Wayne J G

    2016-08-01

    The second Ad Hoc International Society for Sexual Medicine (ISSM) Committee for the Definition of Premature Ejaculation defined acquired premature ejaculation (PE) as a male sexual dysfunction characterized by a the development of a clinically significant and bothersome reduction in ejaculation latency time in men with previous normal ejaculatory experiences, often to about 3 minutes or less, the inability to delay ejaculation on all or nearly all vaginal penetrations, and the presence of negative personal consequences, such as distress, bother, frustration and/or the avoidance of sexual intimacy. The literature contains a diverse range of biological and psychological etiological theories. Acquired PE is commonly due to sexual performance anxiety, psychological or relationship problems, erectile dysfunction (ED), and occasionally prostatitis and hyperthyroidism, consistent with the predominant organic etiology of acquired PE, men with this complaint are usually older, have a higher mean BMI and a greater incidence of comorbid disease including hypertension, sexual desire disorder, diabetes mellitus, chronic prostatitis, and ED compared to lifelong, variable and subjective PE.

  1. The pathophysiology of acquired premature ejaculation

    PubMed Central

    Jannini, Emmanuele A.; Serefoglu, Ege C.; Hellstrom, Wayne J. G.

    2016-01-01

    The second Ad Hoc International Society for Sexual Medicine (ISSM) Committee for the Definition of Premature Ejaculation defined acquired premature ejaculation (PE) as a male sexual dysfunction characterized by a the development of a clinically significant and bothersome reduction in ejaculation latency time in men with previous normal ejaculatory experiences, often to about 3 minutes or less, the inability to delay ejaculation on all or nearly all vaginal penetrations, and the presence of negative personal consequences, such as distress, bother, frustration and/or the avoidance of sexual intimacy. The literature contains a diverse range of biological and psychological etiological theories. Acquired PE is commonly due to sexual performance anxiety, psychological or relationship problems, erectile dysfunction (ED), and occasionally prostatitis and hyperthyroidism, consistent with the predominant organic etiology of acquired PE, men with this complaint are usually older, have a higher mean BMI and a greater incidence of comorbid disease including hypertension, sexual desire disorder, diabetes mellitus, chronic prostatitis, and ED compared to lifelong, variable and subjective PE. PMID:27652216

  2. Distraction Osteogenesis of Multiple Ribs for the Treatment of Acquired Thoracic Dystrophy.

    PubMed

    Piper, Merisa L; Delrosario, Lawrence; Hoffman, William Y

    2016-03-01

    Acquired thoracic dystrophy is a complication associated with early open repair of pectus excavatum resulting from extensive cartilage resection. The condition can cause serious functional and physiologic impairments, including cardiac compression and restrictive pulmonary function. We describe a 17-year-old boy with acquired thoracic dystrophy after Ravitch repair of pectus excavatum during infancy, whom we treated with distraction osteogenesis. The patient had a marked deformity of the chest wall and general hypoplasia of the central portion of the ribcage, with resultant symptomatic dyspnea on exertion and reduced pulmonary function. After osteotomies and distraction osteogenesis of bilateral ribs 4-8 using customized distraction devices, he had improved thoracic contour, resolution of dyspnea, and decreased restrictive pulmonary symptoms. This case suggests that distraction osteogenesis, already used extensively in craniomaxillofacial and orthopedic surgery, may be a novel method for management of this condition.

  3. 48 CFR 1845.502-70 - Contractor-acquired property.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contractor-acquired... Possession of Contractors 1845.502-70 Contractor-acquired property. All contractor-acquired property must be... contractor-acquired. (2) Submission of DD Form 1419, DOD Industrial Plant Requisition, or equivalent...

  4. Transverse deformations of extreme horizons

    NASA Astrophysics Data System (ADS)

    Li, Carmen; Lucietti, James

    2016-04-01

    We consider the inverse problem of determining all extreme black hole solutions to the Einstein equations with a prescribed near-horizon geometry. We investigate this problem by considering infinitesimal deformations of the near-horizon geometry along transverse null geodesics. We show that, up to a gauge transformation, the linearised Einstein equations reduce to an elliptic PDE for the extrinsic curvature of a cross-section of the horizon. We deduce that for a given near-horizon geometry there exists a finite dimensional moduli space of infinitesimal transverse deformations. We then establish a uniqueness theorem for transverse deformations of the extreme Kerr horizon. In particular, we prove that the only smooth axisymmetric transverse deformation of the near-horizon geometry of extreme Kerr, such that cross-sections of the horizon are marginally trapped surfaces, corresponds to that of the extreme Kerr black hole. Furthermore, we determine all smooth and biaxisymmetric transverse deformations of the near-horizon geometry of the five-dimensional extreme Myers-Perry black hole with equal angular momenta. We find a three parameter family of solutions such that cross-sections of the horizon are marginally trapped, which is more general than the known black hole solutions. We discuss the possibility that they correspond to new five-dimensional vacuum black holes.

  5. Chaetal deformities in aquatic oligochaeta

    SciTech Connect

    Brinkhurst, R.O.; Wetzel, M.J.

    1994-12-31

    Gross deformities in the chaetae of specimens of the tubificid Potamothrix hammoniensis were described by Milbrink from Lake Vaenern, Sweden. This lake is one of the most mercury-polluted major lakes of the world. Statistical tests showed a highly significant correlation between the incidence of deformities and the mercury concentration in the sediments. Changes in the pulp and paper mill process led to marked reduction in specimens with deformities. Similarly modified specimens of various species have been observed at a number of sites contaminated with heavy metals or oil residues in North America. Experimental work on chaetal form has demonstrated changes due to conductivity which have also been observed in saline inland waters. These experiments suggest that chaetae may be shed and replaced by worms every few days. EDX observation of chaetae indicated that metals may accumulate in them, and so provide a potential depuration mechanism. Independent physiological studies suggest that worms may be capable of regulating their metal levels.

  6. Finite Deformation of Magnetoelastic Film

    SciTech Connect

    Barham, Matthew Ian

    2011-05-31

    A nonlinear two-dimensional theory is developed for thin magnetoelastic lms capable of large deformations. This is derived directly from three-dimensional theory. Signi cant simpli cations emerge in the descent from three dimensions to two, permitting the self eld generated by the body to be computed a posteriori. The model is specialized to isotropic elastomers with two material models. First weak magnetization is investigated leading to a free energy where magnetization and deformation are un-coupled. The second closely couples the magnetization and deformation. Numerical solutions are obtained to equilibrium boundary-value problems in which the membrane is subjected to lateral pressure and an applied magnetic eld. An instability is inferred and investigated for the weak magnetization material model.

  7. Deformed Richardson-Gaudin model

    NASA Astrophysics Data System (ADS)

    Kulish, P.; Stolin, A.; Johannesson, L. H.

    2014-09-01

    The Richardson-Gaudin model describes strong pairing correlations of fermions confined to a finite chain. The integrability of the Hamiltonian allows the algebraic construction of its eigenstates. In this work we show that the quantum group theory provides a possibility to deform the Hamiltonian preserving integrability. More precisely, we use the so-called Jordanian r-matrix to deform the Hamiltonian of the Richardson-Gaudin model. In order to preserve its integrability, we need to insert a special nilpotent term into the auxiliary L-operator which generates integrals of motion of the system. Moreover, the quantum inverse scattering method enables us to construct the exact eigenstates of the deformed Hamiltonian. These states have a highly complex entanglement structure which require further investigation.

  8. Deformation of Unentangled Swollen Gels

    NASA Astrophysics Data System (ADS)

    Sariyer, Ozan; Panyukov, Sergey; Rubinstein, Michael

    2014-03-01

    We study the deformation characteristics (Poisson's ratios and stress-strain relations) of unentangled gels swollen and uniaxially or biaxially deformed in excess solvent by considering the balance of osmotic pressure and elastic stress in unconstrained dimensions. Our scaling theory predicts a crossover from theta solvent behavior to marginal solvent behavior upon stretching gels that are in concentrated regime at swelling equilibrium - a phenomenon that was experimentally observed long ago, but not understood theoretically. For gels that are in the semidilute good solvent regime at swelling equilibrium, we predict a crossover to theta solvent behavior upon compression and a crossover to marginal solvent behavior upon stretching. Our theory reproduces the previously known results for equilibrium swelling degree as well as known deformation characteristics in theta and athermal solvents.

  9. Shock metamorphism of deformed quartz

    NASA Technical Reports Server (NTRS)

    Gratz, Andrew J.; Christie, John; Tyburczy, James; Ahrens, Thomas; Pongratz, Peter

    1988-01-01

    The effect produced by shock loading (to peak pressures of 12 and 24) on deformed synthetic quartz containing a dislocation and abundant bubbles and small inclusions was investigated, and the relationships between preexisting dislocation density shock lamellae in the target material were examined. The resultant material was found to be inhomogeneously deformed and extremely fractured. Results of TEM examinations indicate that no change in dislocation density was caused by shock loading except in regions containing shock lamellae, where the dislocation density was lowered. The shock-induced defects tend to nucleate on and be controlled by preexisting stress concentrators; shock lamellae, glassy veins, and most curviplanar defects form in tension, presumably during release. An extremely mobile silica fluid is formed and injected into fractures during release, which forcibly removes crystalline fragments from vein walls. It is concluded that shock deformation in quartz is dominated by fracture and melting.

  10. Deformation processes in forging ceramics

    NASA Technical Reports Server (NTRS)

    Cannon, R. M.; Rhodes, W. H.

    1973-01-01

    The deformation processes involved in the forging of refractory ceramic oxides were investigated. A combination of mechanical testing and forging was utilized to investigate both the flow and fracture processes involved. Deformation studies of very fine grain Al203 revealed an apparent transition in behavior, characterized by a shift in the strain rate sensitivity from 0.5 at low stresses to near unity at higher stresses. The behavior is indicative of a shift in control between two dependent mechanisms, one of which is indicated to be cation limited diffusional creep with significant boundary enhancement. The possible contributions of slip, indicated by crystallographic texture, interface control of the diffusional creep and inhomogeneous boundary sliding are also discussed. Additional experiments indicated an independence of deformation behavior on MgO doping and retained hot pressing impurities, at least for ultrafine grained material, and also an independence of test atmosphere.

  11. Microstructure of deformed graywacke sandstones

    SciTech Connect

    Dengler, L.A.

    1980-03-05

    Microsctures in low-permeability graywacke sandstones were studied by optical and scanning electron microscopy (SEM). SEM specimens were prepared by ion-bombardment of thick polished samples. The undeformed rock contains grains in a matrix composed primarily of authigenic chlorite and kaolinite. Chlorite platelets are randomly arranged in face-to-edge relation to one another. Kaolinite occurs as pseudohexagonal crystals stacked face-to-face in pore filling books. Uniaxial-stress experiments covered a range of confining pressures from .1 to 600 MPa. Below 50 MPa confining pressure, intergranular fracturing occurs within the fault zone and near the sample's cylindrical surface. Between 100 and 300 MPa confining pressure, fault zones contain highly fractured grains, gauge and slickensides on grain surfaces. At 600 MPa, the sample contains a diffuse shear zone of highly fractured grains and no well-defined fault. In all samples, the distribution of microcracks is heterogeneous. Different clay minerals exhibit different modes of deformation. Chlorite structure responds to applied stress by compaction, reducing both pore size and volume. Chlorite platelets are plastically deformed in even the least strained samples. Kaolinite does not deform plastically in any of the samples examined. Deformation of kaolinite is restricted to toppling of the book structure. Dilatant crack growth was studied in two samples unloaded prior to failure. Uniaxially-strained samples deform primarily along grain boundaries, producing intergranular cracks and realignment of chlorite platelets. Intragranular crack density is linearly related to axial-strain, although grains are less fractured than in uniaxially-stressed samples tested at equivalent mean pressures. Cracks are rarely longer than a grain diameter. Nuclear-explosively deformed samples were recovered after the Rio Blanco gas stimulation experiment. (JGB)

  12. Semiautomated four-dimensional computed tomography segmentation using deformable models

    SciTech Connect

    Ragan, Dustin; Starkschall, George; McNutt, Todd; Kaus, Michael; Guerrero, Thomas; Stevens, Craig W.

    2005-07-15

    The purpose of this work is to demonstrate a proof of feasibility of the application of a commercial prototype deformable model algorithm to the problem of delineation of anatomic structures on four-dimensional (4D) computed tomography (CT) image data sets. We acquired a 4D CT image data set of a patient's thorax that consisted of three-dimensional (3D) image data sets from eight phases in the respiratory cycle. The contours of the right and left lungs, cord, heart, and esophagus were manually delineated on the end inspiration data set. An interactive deformable model algorithm, originally intended for deforming an atlas-based model surface to a 3D CT image data set, was applied in an automated fashion. Triangulations based on the contours generated on each phase were deformed to the CT data set on the succeeding phase to generate the contours on that phase. Deformation was propagated through the eight phases, and the contours obtained on the end inspiration data set were compared with the original manually delineated contours. Structures defined by high-density gradients, such as lungs, cord, and heart, were accurately reproduced, except in regions where other gradient boundaries may have confused the algorithm, such as near bronchi. The algorithm failed to accurately contour the esophagus, a soft-tissue structure completely surrounded by tissue of similar density, without manual interaction. This technique has the potential to facilitate contour delineation in 4D CT image data sets; and future evolution of the software is expected to improve the process.

  13. Roughness parameters and surface deformation measured by coherence radar

    NASA Astrophysics Data System (ADS)

    Ettl, Peter; Schmidt, Berthold E.; Schenk, M.; Laszlo, Ildiko; Haeusler, Gerd

    1998-09-01

    The 'coherence radar' was introduced as a method to measure the topology of optically rough surfaces. The basic principle is white light interferometry in individual speckles. We will discuss the potentials and limitations of the coherence radar to measure the microtopology, the roughness parameters, and the out of plane deformation of smooth and rough object surfaces. We have to distinguish objects with optically smooth (polished) surfaces and with optically rough surfaces. Measurements at polished surfaces with simple shapes (flats, spheres) are the domain of classical interferometry. We demonstrate new methods to evaluate white light interferograms and compare them to the standard Fourier evaluation. We achieve standard deviations of the measured signals of a few nanometers. We further demonstrate that we can determine the roughness parameters of a surface by the coherence radar. We use principally two approaches: with very high aperture the surface topology is laterally resolved. From the data we determine the roughness parameters according to standardized evaluation procedures, and compare them with mechanically acquired data. The second approach is by low aperture observation (unresolved topology). Here the coherence radar supplies a statistical distance signal from which we can determine the standard deviation of the surface height variations. We will further discuss a new method to measure the deformation of optically rough surfaces, based on the coherence radar. Unless than with standard speckle interferometry, the new method displays absolute deformation. For small out-of-plane deformation (correlated speckle), the potential sensitivity is in the nanometer regime. Large deformations (uncorrelated speckle) can be measured with an uncertainty equal to the surface roughness.

  14. Deformation and Fracture of Shale at the Nanoscale

    NASA Astrophysics Data System (ADS)

    Bennett, K. C.; Borja, R. I.

    2013-12-01

    The deformation and fracture properties of shales depend on the mechanical properties of their basic constituents, including the solid clay particles, inclusions such as silt and organics, and the multi-scale porosity comprised of existing micro-fractures and the nano-scale porosity of the porous clay matrix. A great deal of understanding of the overall macroscopic (field scale) mechanical properties of shales can be gained by studying the deformation and fracture properties of these constituents along with their composite behavior, i.e., the mechanisms of deformation and fracture of shale. This project builds upon our recently acquired ability to image with fixed ion beam scanning electron microscopy (FIB-SEM) the 3D geometry of a porous shale sample to nanometer resolution, as well as to test this sample on a nanoindenter at both the particle and composite scales, in order to develop a 3D mechanistic model to interpret the results of nanoindentation tests. The pore-scale study considers the intrinsic deformation and fracture properties of clay particles, and the effect of silt inclusions and particle packing into an anisotropic composite matrix. The analysis accounts for anisotropic and heterogeneous shale elasticity, plasticity, damage, and fissility. A finite element (FE) model is being developed which uses a recently developed finite deformation crystal plasticity algorithm and an enhanced FE method for capturing strong discontinuity. The model aims to capture the effects of the particle elasticity, plastic yielding, and the damage induced by the indenter, including the fracturing and chipping within the mineral grains and around the perimeter of the indent. Anisotropy of fracture properties is examined with respect to delamination of the clay matrix in the bed-parallel direction and to breaking of plate-like clay particles. The ultimate goal of this research is to establish a framework for investigating the poromechanical properties of shale at the nano

  15. SU-E-J-111: Finite Element-Based Deformable Image Registration of Pleural Cavity for Photodynamic Therapy

    SciTech Connect

    Penjweini, R; Zhu, T

    2015-06-15

    Purpose: The pleural volumes will deform during surgery portion of the pleural photodynamic therapy (PDT) of lung cancer when the pleural cavity is opened. This impact the delivered dose when using highly conformal treatment techniques. In this study, a finite element-based (FEM) deformable image registration is used to quantify the anatomical variation between the contours for the pleural cavities obtained in the operating room and those determined from pre-surgery computed tomography (CT) scans. Methods: An infrared camera-based navigation system (NDI) is used during PDT to track the anatomical changes and contour the lung and chest cavity. A series of CTs of the lungs, in the same patient, are also acquired before the surgery. The structure contour of lung and the CTs are processed and contoured in Matlab and MeshLab. Then, the contours are imported into COMSOL Multiphysics 5.0, where the FEM-based deformable image registration is obtained using the deformed mesh - moving mesh (ALE) model. The NDI acquired lung contour is considered as the reference contour, and the CT contour is used as the target one, which will be deformed. Results: The reconstructed three-dimensional contours from both NDI and CT can be converted to COMSOL so that a three-dimensional ALE model can be developed. The contours can be registered using COMSOL ALE moving mesh model, which takes into account the deformation along x, y and z-axes. The deformed contour has good matches to the reference contour after the dynamic matching process. The resulting 3D deformation map can be used to obtain the locations of other critical anatomic structures, e.g., heart, during surgery. Conclusion: Deformable image registration can fuse images acquired by different modalities. It provides insights into the development of phenomenon and variation in normal anatomical structures over time. The initial assessments of three-dimensional registration show good agreement.

  16. Controllable objective with deformable mirrors

    SciTech Connect

    Agafonov, V V; Safronov, A G

    2004-03-31

    A new optical device - an objective with deformable mirrors and parameters controlled in the dynamic regime is proposed. The computer simulation of the objective is performed. The dependences of some parameters of the objective on the control voltage are determined. The simulation showed that the ranges of control of the rear focal segment and the focal distance for the objective with the focal distance 602 mm were 1057 and 340 mm, respectively, which is substantially greater than in the control of an equivalent deformable mirror. (laser applications and other topics in quantum electronics)

  17. Analytical volcano deformation source models

    USGS Publications Warehouse

    Lisowski, Michael; Dzurisin, Daniel

    2007-01-01

    Primary volcanic landforms are created by the ascent and eruption of magma. The ascending magma displaces and interacts with surrounding rock and fluids as it creates new pathways, flows through cracks or conduits, vesiculates, and accumulates in underground reservoirs. The formation of new pathways and pressure changes within existing conduits and reservoirs stress and deform the surrounding rock. Eruption products load the crust. The pattern and rate of surface deformation around volcanoes reflect the tectonic and volcanic processes transmitted to the surface through the mechanical properties of the crust.

  18. Ilizarov principles of deformity correction.

    PubMed

    Spiegelberg, B; Parratt, T; Dheerendra, S K; Khan, W S; Jennings, R; Marsh, D R

    2010-03-01

    Ilizarov frames provide a versatile fixation system for the management of bony deformities, fractures and their complications. The frames give stability, soft tissue preservation, adjustability and functionality allowing bone to realise its full osteogenic potential. It is important that we have a clear and concise understanding of the Ilizarov principles of deformity correction to best make use of this fixation system. In this review article, the history of Ilizarov frame, the basic sciences behind it, the mechanical principles governing its use and the clinical use of the fixation system are discussed.

  19. Ilizarov principles of deformity correction

    PubMed Central

    Spiegelberg, B; Parratt, T; Dheerendra, SK; Khan, WS; Jennings, R; Marsh, DR

    2010-01-01

    Ilizarov frames provide a versatile fixation system for the management of bony deformities, fractures and their complications. The frames give stability, soft tissue preservation, adjustability and functionality allowing bone to realise its full osteogenic potential. It is important that we have a clear and concise understanding of the Ilizarov principles of deformity correction to best make use of this fixation system. In this review article, the history of Ilizarov frame, the basic sciences behind it, the mechanical principles governing its use and the clinical use of the fixation system are discussed. PMID:20353638

  20. Cavity coalescence in superplastic deformation

    SciTech Connect

    Stowell, M.J.; Livesey, D.W.; Ridley, N.

    1984-01-01

    An analysis of the probability distribution function of particles randomly dispersed in a solid has been applied to cavitation during superplastic deformation and a method of predicting cavity coalescence developed. Cavity size distribution data were obtained from two microduplex nickel-silver alloys deformed superplastically to various extents at elevated temperature, and compared to theoretical predictions. Excellent agreement occurred for small void sizes but the model underestimated the number of voids in the largest size groups. It is argued that the discrepancy results from a combination of effects due to non-random cavity distributions and to enhanced growth rates and incomplete spheroidization of the largest cavities.

  1. UAV for landslide mapping and deformation analysis

    NASA Astrophysics Data System (ADS)

    Shi, Beiqi; Liu, Chun

    2015-12-01

    Unmanned aerial vehicle (UAV) can be a flexible, cost-effective, and accurate method to monitor landslides with high resolution aerial images. Images acquired on 05 May 2013 and 13 December 2014 of the Xishan landslide, China, have been used to produce a high-resolution ortho-mosaic of the entire landslide and digital elevation model (DEM). The UAV capability for imaging detection and displacements on the landslide surface has been evaluated, and the subsequent image processing approaches for suitably georectifying the data have been assessed. Objects derived from the segmentation of a multispectral image were used as classifying units for landslide object-oriented analysis. Spectral information together with various morphometric characteristics was applied for recognizing landslides from false positives. Digital image correlation technique was evaluated to quantify and map terrain displacements. The magnitude and direction of the displacement vectors derived from correlating two temporal UAV images corresponded to a visual interpretation of landslide change. Therefore, the UAV can demonstrate its capability for producing valuable landslide mapping data and deformation information.

  2. Validation of an accelerated 'demons' algorithm for deformable image registration in radiation therapy

    NASA Astrophysics Data System (ADS)

    Wang, He; Dong, Lei; O'Daniel, Jennifer; Mohan, Radhe; Garden, Adam S.; Kian Ang, K.; Kuban, Deborah A.; Bonnen, Mark; Chang, Joe Y.; Cheung, Rex

    2005-06-01

    A greyscale-based fully automatic deformable image registration algorithm, originally known as the 'demons' algorithm, was implemented for CT image-guided radiotherapy. We accelerated the algorithm by introducing an 'active force' along with an adaptive force strength adjustment during the iterative process. These improvements led to a 40% speed improvement over the original algorithm and a high tolerance of large organ deformations. We used three methods to evaluate the accuracy of the algorithm. First, we created a set of mathematical transformations for a series of patient's CT images. This provides a 'ground truth' solution for quantitatively validating the deformable image registration algorithm. Second, we used a physically deformable pelvic phantom, which can measure deformed objects under different conditions. The results of these two tests allowed us to quantify the accuracy of the deformable registration. Validation results showed that more than 96% of the voxels were within 2 mm of their intended shifts for a prostate and a head-and-neck patient case. The mean errors and standard deviations were 0.5 mm ± 1.5 mm and 0.2 mm ± 0.6 mm, respectively. Using the deformable pelvis phantom, the result showed a tracking accuracy of better than 1.5 mm for 23 seeds implanted in a phantom prostate that was deformed by inflation of a rectal balloon. Third, physician-drawn contours outlining the tumour volumes and certain anatomical structures in the original CT images were deformed along with the CT images acquired during subsequent treatments or during a different respiratory phase for a lung cancer case. Visual inspection of the positions and shapes of these deformed contours agreed well with human judgment. Together, these results suggest that the accelerated demons algorithm has significant potential for delineating and tracking doses in targets and critical structures during CT-guided radiotherapy.

  3. Validation of an accelerated 'demons' algorithm for deformable image registration in radiation therapy.

    PubMed

    Wang, He; Dong, Lei; O'Daniel, Jennifer; Mohan, Radhe; Garden, Adam S; Ang, K Kian; Kuban, Deborah A; Bonnen, Mark; Chang, Joe Y; Cheung, Rex

    2005-06-21

    A greyscale-based fully automatic deformable image registration algorithm, originally known as the 'demons' algorithm, was implemented for CT image-guided radiotherapy. We accelerated the algorithm by introducing an 'active force' along with an adaptive force strength adjustment during the iterative process. These improvements led to a 40% speed improvement over the original algorithm and a high tolerance of large organ deformations. We used three methods to evaluate the accuracy of the algorithm. First, we created a set of mathematical transformations for a series of patient's CT images. This provides a 'ground truth' solution for quantitatively validating the deformable image registration algorithm. Second, we used a physically deformable pelvic phantom, which can measure deformed objects under different conditions. The results of these two tests allowed us to quantify the accuracy of the deformable registration. Validation results showed that more than 96% of the voxels were within 2 mm of their intended shifts for a prostate and a head-and-neck patient case. The mean errors and standard deviations were 0.5 mm+/-1.5 mm and 0.2 mm+/-0.6 mm, respectively. Using the deformable pelvis phantom, the result showed a tracking accuracy of better than 1.5 mm for 23 seeds implanted in a phantom prostate that was deformed by inflation of a rectal balloon. Third, physician-drawn contours outlining the tumour volumes and certain anatomical structures in the original CT images were deformed along with the CT images acquired during subsequent treatments or during a different respiratory phase for a lung cancer case. Visual inspection of the positions and shapes of these deformed contours agreed well with human judgment. Together, these results suggest that the accelerated demons algorithm has significant potential for delineating and tracking doses in targets and critical structures during CT-guided radiotherapy.

  4. Ground Surface Deformation Around Tehran due to Groundwater Recharge: InSAR Monitoring.

    NASA Astrophysics Data System (ADS)

    Gourmelen, N.; Peyret, M.; Chery, J.; Ritz, J.

    2002-12-01

    Tehran is located on an active tectonic and seismic zone. The surface deformation monitoring provides a powerful tool for getting a better understanding of faults kinematics and mechanisms. Used in conjunction with GPS networks, InSAR (Interferometric Synthetic Aperture Radar) provides dense and precise deformation measurements which are essential for mapping complex heterogeneous deformation fields. Moreover, urban and arid areas preserve interferometric phase coherence. The archived acquisitions of ERS that span 9 months between September 1998 and June 1999 reveal wide areas of surface uplift (by as much as 9 cm). This vertical deformation (gradual in time) has probably no tectonic meaning but is rather the ground response to ground water recharge. These zones are all located dowstream of large alluvial fans like the one of Karaj. The variation of effective stress caused by intersticial water draining could explain such surface deformation. It can also be noticed that some faults act as boundary for these deformation zones and fluid motion. The understanding of this deformation is relevant for groundwater monitoring and urban developement management. It is also necessary for discriminating it from tectonic deformation that also occurs on this zone. Due to the lack of attitude control of satellite ERS-2 since February 2001, the last images acquired could not be combined with the former acquisitions. Nevertheless, we expect to be able to enrich our set of images in order to map tectonic deformation on a longer period and to monitor in a more continuous way the deformation due to groundwater evolution. This would allow to quantify the permanent and reversible part of this signal.

  5. Ground Surface Deformation around Tehran due to Groundwater Recharge: InSAR Monitoring.

    NASA Astrophysics Data System (ADS)

    Gourmelen, N.; Peyret, M.; Fritz, J. F.; Cherry, J.

    2003-04-01

    Tehran is located on an active tectonic and seismic zone. The surface deformation monitoring provides a powerful tool for getting a better understanding of faults kinematics and mechanisms. Used in conjunction with GPS networks, InSAR (Interferometric Synthetic Aperture Radar) provides dense and precise deformation measurements which are essential for mapping complex heterogeneous deformation fields. Moreover, urban and arid areas preserve interferometric phase coherence. The archived acquisitions of ERS that span 9 months between September 1998 and June 1999 reveal wide areas of surface uplift (by as much as 9 cm). This vertical deformation (gradual in time) has probably no tectonic meaning but is rather the ground response to ground water recharge. These zones are all located dowstream of large alluvial fans like the one of Karaj. The variation of effective stress caused by intersticial water draining could explain such surface deformation. It can also be noticed that some faults act as boundary for these deformation zones and fluid motion. The understanding of this deformation is relevant for groundwater monitoring and urban developement management. It is also necessary for discriminating it from tectonic deformation that also occurs on this zone. Due to the lack of attitude control of satellite ERS-2 since February 2001, the last images acquired could not be combined with the former acquisitions. Nevertheless, we expect to be able to enrich our set of images in order to map tectonic deformation on a longer period and to monitor in a more continuous way the deformation due to groundwater evolution. This would allow to quantify the permanent and reversible part of this signal.

  6. Acquired prosopagnosia without word recognition deficits.

    PubMed

    Susilo, Tirta; Wright, Victoria; Tree, Jeremy J; Duchaine, Bradley

    2015-01-01

    It has long been suggested that face recognition relies on specialized mechanisms that are not involved in visual recognition of other object categories, including those that require expert, fine-grained discrimination at the exemplar level such as written words. But according to the recently proposed many-to-many theory of object recognition (MTMT), visual recognition of faces and words are carried out by common mechanisms [Behrmann, M., & Plaut, D. C. ( 2013 ). Distributed circuits, not circumscribed centers, mediate visual recognition. Trends in Cognitive Sciences, 17, 210-219]. MTMT acknowledges that face and word recognition are lateralized, but posits that the mechanisms that predominantly carry out face recognition still contribute to word recognition and vice versa. MTMT makes a key prediction, namely that acquired prosopagnosics should exhibit some measure of word recognition deficits. We tested this prediction by assessing written word recognition in five acquired prosopagnosic patients. Four patients had lesions limited to the right hemisphere while one had bilateral lesions with more pronounced lesions in the right hemisphere. The patients completed a total of seven word recognition tasks: two lexical decision tasks and five reading aloud tasks totalling more than 1200 trials. The performances of the four older patients (3 female, age range 50-64 years) were compared to those of 12 older controls (8 female, age range 56-66 years), while the performances of the younger prosopagnosic (male, 31 years) were compared to those of 14 younger controls (9 female, age range 20-33 years). We analysed all results at the single-patient level using Crawford's t-test. Across seven tasks, four prosopagnosics performed as quickly and accurately as controls. Our results demonstrate that acquired prosopagnosia can exist without word recognition deficits. These findings are inconsistent with a key prediction of MTMT. They instead support the hypothesis that face

  7. [Iris heterochromia in acquired Horner's syndrome].

    PubMed

    Beynat, J; Soichot, P; Bidot, S; Dugas, B; Creuzot-Garcher, C; Bron, A

    2007-09-01

    Horner's syndrome (HS) is related to an interruption of the oculosympathetic nerve pathway. The classic clinical findings associated with this condition are ptosis, miosis, and enophthalmos. Heterochromia is typically described in congenital HS, but it is an uncommon finding in acquired HS. We report a case of post-traumatic HS associated with heterochromia. A literature review indicates that this type of heterochromia may be related to a reduction in the number of iris melanocytes. This mechanism may be the same in the physiological iris color modifications in adulthood.

  8. [Acquired immunodeficiency syndrome in pediatric patients].

    PubMed

    Molina Moguel, J L; Ruiz Illezcas, R; Forsbach Sánchez, S; Carreño Alvarez, S; Picco Díaz, I

    1990-12-01

    The object of this study was to determine how many of the patients treated at the Pediatric Odontology Clinic, a branch of the Maxillo-Facial Surgery Service at the Veinte de Noviembre Regional Hospital, ISSSTE, are VIH-positive of show serious manifestations of Acquired Immuno-Deficiency Syndrome (AIDS). For such purpose, 100 pediatric patients suffering from different systemic or local diseases were evaluated, the most common being hematological alterations. Results evidenced the presence of VIH in the blood of five of the pediatric subjects, all suffering from Hemophilia.

  9. Origins of species: acquired genomes and individuality

    NASA Technical Reports Server (NTRS)

    Margulis, L.

    1993-01-01

    Entire genomes with their accompanying protein synthetic systems are transferred throughout the biosphere primarily as bacteria and protists which become symbionts as they irreversibly integrate into pre-existing organisms to form more complex individuals. Individualization is stabilized by simultaneous transmission of once-separate heterologous genetic systems. The origin of new species is hypothesized to correlate with the acquisition, integration and subsequent inheritance of such acquired microbial genomes. These processes were recognized by Mereschkovsky ("Symbiogenesis" in Russian, 1909) and by Wallin ("Symbionticism", see p. 181, this issue).

  10. Common acquired causes of thrombosis in children.

    PubMed

    Tolbert, Jaszianne; Carpenter, Shannon L

    2013-08-01

    Compared to adults, venous thromboembolism in the pediatric population is a rare event. Cancer, cardiac disease, antiphospholipid antibodies, and indwelling catheters are established risk factors for thromboembolism in children. We examined the literature related to thrombophilia in children, childhood cancer and thrombosis, cardiac disease and thrombosis, and antiphospholipid antibody syndrome in children. Citations in identified articles yielded additional articles for review. We found that studies of acquired thrombophilia in children are limited. Current treatment for thromboembolism in children is based on adult data therefore optimal treatment in this population remains unclear.

  11. Acquired Congenital Malalignment of the Great Toenails

    PubMed Central

    Decker, Ashley; Scher, Richard K.; Avarbock, Andrew

    2016-01-01

    Congenital malalignment is the lateral deviation of the nail plate along the longitudinal axis due to the lateral rotation of the nail matrix. The nail plate grows out in ridges caused by repeated microtrauma to the nail. Common complications include onychomycosis, Pseudomonas infection and acute or chronic paronychia. Treatment options range from conservative management to surgical options including realignment and nail matrixectomy. Congenital malalignment usually presents in infancy or childhood, but we present two cases of acquired malalignment occurring in the teenage years. PMID:27171597

  12. Three dimensional deformation of dry-stored complete denture base at room temperature

    PubMed Central

    2016-01-01

    PURPOSE The aim of this study was to evaluate whether there is any typical deformation pattern existing in complete denture when it was dried by using the 3D scanner and surface matching program. MATERIALS AND METHODS A total of 28 denture bases were fabricated with heat curing acrylic resin (each 14 upper and lower denture bases), and 14 denture bases (each 7 upper and lower denture bases) were stored in the water bottle (water stored), and another 14 denture bases were stored in the air (dry stored). Each specimen was scanned at 1st day after deflasking, 14th day after deflasking, and 28th day after deflasking, and digitalized. Three dimensional deformation patterns were acquired by comparison of the data within storage group using surface matching program. For evaluating differences between groups, these data were compared statisticallyusing Kruskal Wallis and Mann Whitney-U test (α=.05). RESULTS When evaluating 3D deformation of denture base, obvious deformations were not found in maxillary and mandibular water storage group. However, in dry stored group, typical deformation pattern was detected as storage time passes. It occurred mostly in first two weeks. Major deformations were found in the bilateral posterior area in both maxillary and mandibular group. In maxillary dry stored group, a statistical significance was found. CONCLUSION It was proved that in both upper and lower denture bases, dry storage caused more dimensional deformation than water storage with typical pattern. PMID:27555899

  13. Foot deformities in Renaissance paintings. A mystery of symbolism, artistic licence, illusion and true representation in five renowned Renaissance painters.

    PubMed

    Lazzeri, D; Castello, M F; Grassetti, L; Dashti, T; Zhang, Y X; Persichetti, P

    2015-01-01

    Although Renaissance artists were skilled in representing normal anatomy, a close look at some paintings reveals anatomical variations in the depiction of the feet of human figures. A systematic review has identified 25 paintings by five artists in which the presumptive medico-artistic diagnosis of congenital or acquired foot deformity seems to be varyingly present. The connection between these five painters and what factors have influenced artists' style in the depiction of such deformities is discussed. The possible iconography and medical-historical meaning of such variations, as well as the possibility of artistic licence and real representation that drove the painters to depict these deformities, is explored and debated.

  14. Acquired and congenital coronary artery abnormalities.

    PubMed

    Young, Ming-Lon; McLeary, Michael; Chan, Kak-Chen

    2017-01-01

    Sudden unexpected cardiac deaths in approximately 20% of young athletes are due to acquired or congenital coronary artery abnormalities. Kawasaki disease is the leading cause for acquired coronary artery abnormalities, which can cause late coronary artery sequelae including aneurysms, stenosis, and thrombosis, leading to myocardial ischaemia and ventricular fibrillation. Patients with anomalous left coronary artery from the pulmonary artery can develop adequate collateral circulation from the right coronary artery in the newborn period, which remains asymptomatic only to manifest in adulthood with myocardial ischaemia, ventricular arrhythmias, and sudden death. Anomalous origin of coronary artery from the opposite sinus occurs in 0.7% of the young general population aged between 11 and 15 years. If the anomalous coronary artery courses between the pulmonary artery and the aorta, sudden cardiac death may occur during or shortly after vigorous exercise, especially in patients where the anomalous left coronary artery originates from the right sinus of Valsalva. Symptomatic patients with evidence of ischaemia should have surgical correction. No treatment is needed for asymptomatic patients with an anomalous right coronary artery from the left sinus of Valsalva. At present, there is no consensus regarding how to manage asymptomatic patients with anomalous left coronary artery from the right sinus of Valsalva and interarterial course. Myocardial bridging is commonly observed in cardiac catheterisation and it rarely causes exercise-induced coronary syndrome or cardiac death. In symptomatic patients, refractory or β-blocker treatment and surgical un-bridging may be considered.

  15. Software for Acquiring Image Data for PIV

    NASA Technical Reports Server (NTRS)

    Wernet, Mark P.; Cheung, H. M.; Kressler, Brian

    2003-01-01

    PIV Acquisition (PIVACQ) is a computer program for acquisition of data for particle-image velocimetry (PIV). In the PIV system for which PIVACQ was developed, small particles entrained in a flow are illuminated with a sheet of light from a pulsed laser. The illuminated region is monitored by a charge-coupled-device camera that operates in conjunction with a data-acquisition system that includes a frame grabber and a counter-timer board, both installed in a single computer. The camera operates in "frame-straddle" mode where a pair of images can be obtained closely spaced in time (on the order of microseconds). The frame grabber acquires image data from the camera and stores the data in the computer memory. The counter/timer board triggers the camera and synchronizes the pulsing of the laser with acquisition of data from the camera. PIVPROC coordinates all of these functions and provides a graphical user interface, through which the user can control the PIV data-acquisition system. PIVACQ enables the user to acquire a sequence of single-exposure images, display the images, process the images, and then save the images to the computer hard drive. PIVACQ works in conjunction with the PIVPROC program which processes the images of particles into the velocity field in the illuminated plane.

  16. [HIV infection and acquired immunodeficiency syndrome].

    PubMed

    Takamatsu, J

    1997-05-01

    On June 4, 1981, MMWR published a report about Pneumocystis carinii pneumonia in homosexual men in Los Angeles. This was the first published report. A years later, this disease was named acquired immunodeficiency syndrome (AIDS). In the following year, Montangier et al in France discovered the causative agent, which they called lymphadenopathy virus (LAV), now known as human immunodeficiency virus (HIV). In 1985, solid-phase enzymeimmunoassay for the detection of the antibody to HIV was developed. Since then, other new techniques for the identification of HIV infection have been become available. These include more sensitive methods (for example; polymerase chain reaction techniques). Although these techniques facilitate early and definite diagnosis of infection, these tests may fail to detect the antibody in sera during window period of infection or overdiagnose infection in sera contaminated with genes not related to HIV. Although preventing blood exposure is the primary means of preventing occupationally acquired human immunodeficiency virus (HIV) infection, appropriate post-exposure management is an important element of workplace safety. Information suggesting that zidovudine (ZDV) postexposure prophylaxis (PEP) may reduce the risk for HIV transmission after occupational exposure to HIV infected blood prompted a Public Health Service (PHS) interagency working group, with expert consultation, and recommendations on PEP and management of occupational exposure to HIV in relation to these findings were discussed.

  17. Treatment of community-acquired pneumonia.

    PubMed

    Lee, Young R; Houngue, Coovi; Hall, Ronald G

    2015-01-01

    Community-acquired pneumonia is the sixth leading cause of death in the USA. Adherence to the 2007 Infectious Diseases Society of America/American Thoracic Society community-acquired pneumonia guidelines has been associated with improved clinical outcomes. However, choice between guideline-recommended treatments is at the discretion of the prescribing clinician. This review is intended to discuss the characteristics of these treatment options including dosing frequency, dose adjustment for renal/hepatic dysfunction, serious/common adverse events, drug interactions, lung penetration, pharmacokinetic-pharmacodynamic target and effect of obesity to help guide antimicrobial selection. An increasing portion of patients are receiving expanded empiric coverage for methicillin-resistant Staphylococcus aureus as recommended by the American Thoracic Society and Infectious Diseases Society of America for healthcare-associated pneumonia. However, this expanded coverage may not be achieving the desired improvements in clinical outcomes. We expect this increasingly diverse spectrum of patients with pneumonia to eventually result in the merger of these two guidelines to include all patients with pneumonia.

  18. Clinicopathological correlation of acquired hyperpigmentary disorders.

    PubMed

    Patel, Anisha B; Kubba, Raj; Kubba, Asha

    2013-01-01

    Acquired pigmentary disorders are group of heterogenous entities that share single, most significant, clinical feature, that is, dyspigmentation. Asians and Indians, in particular, are mostly affected. Although the classic morphologies and common treatment options of these conditions have been reviewed in the global dermatology literature, the value of histpathological evaluation has not been thoroughly explored. The importance of accurate diagnosis is emphasized here as the underlying diseases have varying etiologies that need to be addressed in order to effectively treat the dyspigmentation. In this review, we describe and discuss the utility of histology in the diagnostic work of hyperpigmentary disorders, and how, in many cases, it can lead to targeted and more effective therapy. We focus on the most common acquired pigmentary disorders seen in Indian patients as well as a few uncommon diseases with distinctive histological traits. Facial melanoses, including mimickers of melasma, are thoroughly explored. These diseases include lichen planus pigmentosus, discoid lupus erythematosus, drug-induced melanoses, hyperpigmentation due to exogenous substances, acanthosis nigricans, and macular amyloidosis.

  19. The Acquired Immunodeficiency Syndrome: current status.

    PubMed Central

    Quagliarello, V.

    1982-01-01

    A recently recognized syndrome of acquired immunodeficiency (Acquired Immunodeficiency Syndrome-AIDS) has arisen since June 1981. It has received international attention. The clinical spectrum consists of repeated opportunistic infections, rare malignancies, and autoimmune phenomena, occurring in previously healthy adults with no history of an immunologic disorder. The population subset at risk for this syndrome appears to be predominantly homosexual American males and intravenous drug abusers with rare cases being reported in heterosexuals, hemophiliacs, and foreign patients, especially Haitians. The immunologic aberrancy in all patients described appears limited to T-lymphocyte hyporesponsiveness and imbalance of T-helper and suppressor cells. This disordered immunoregulation is a consistent finding in all reported cases and appears to predispose to the opportunistic infections and malignancies which have been associated with a 40 percent mortality. The underlying factor responsible for the immunoregulatory defect is unknown but possible etiologies include a transmissible infectious agent, drug use, chronic antigen stimulation, and spermatozoa exposure. Treatment of the associated infections and malignancies has been a frustrating endeavor as many patients respond incompletely or relapse soon after successful treatment course. Preventive measures, including patient education, physician awareness, and immunomodulating agents, are discussed. PMID:6134399

  20. Highly deformable nanofilaments in flow

    NASA Astrophysics Data System (ADS)

    Pawłowska, S.

    2016-10-01

    Experimental analysis of hydrogel nanofilaments conveyed by flow is conducted to help in understanding physical phenomena responsible for transport properties and shape deformations of long bio-objects, like DNA or proteins. Investigated hydrogel nanofilaments exhibit typical macromolecules-like behavior, as spontaneous conformational changes and cross-flow migration. Results of the experiments indicate critical role of thermal fluctuations behavior of single filaments.

  1. Quantitative assessment of soft tissue deformation using digital speckle pattern interferometry: studies on phantom breast models.

    PubMed

    Karuppanan, Udayakumar; Unni, Sujatha Narayanan; Angarai, Ganesan R

    2017-01-01

    Assessment of mechanical properties of soft matter is a challenging task in a purely noninvasive and noncontact environment. As tissue mechanical properties play a vital role in determining tissue health status, such noninvasive methods offer great potential in framing large-scale medical screening strategies. The digital speckle pattern interferometry (DSPI)-based image capture and analysis system described here is capable of extracting the deformation information from a single acquired fringe pattern. Such a method of analysis would be required in the case of the highly dynamic nature of speckle patterns derived from soft tissues while applying mechanical compression. Soft phantoms mimicking breast tissue optical and mechanical properties were fabricated and tested in the DSPI out of plane configuration set up. Hilbert transform (HT)-based image analysis algorithm was developed to extract the phase and corresponding deformation of the sample from a single acquired fringe pattern. The experimental fringe contours were found to correlate with numerically simulated deformation patterns of the sample using Abaqus finite element analysis software. The extracted deformation from the experimental fringe pattern using the HT-based algorithm is compared with the deformation value obtained using numerical simulation under similar conditions of loading and the results are found to correlate with an average %error of 10. The proposed method is applied on breast phantoms fabricated with included subsurface anomaly mimicking cancerous tissue and the results are analyzed.

  2. Model Deformation Measurements at NASA Langley Research Center

    NASA Technical Reports Server (NTRS)

    Burner, A. W.

    1998-01-01

    Only recently have large amounts of model deformation data been acquired in NASA wind tunnels. This acquisition of model deformation data was made possible by the development of an automated video photogrammetric system to measure the changes in wing twist and bending under aerodynamic load. The measurement technique is based upon a single view photogrammetric determination of two dimensional coordinates of wing targets with a fixed third dimensional coordinate, namely the spanwise location. A major consideration in the development of the measurement system was that use of the technique must not appreciably reduce wind tunnel productivity. The measurement technique has been used successfully for a number of tests at four large production wind tunnels at NASA and a dedicated system is nearing completion for a fifth facility. These facilities are the National Transonic Facility, the Transonic Dynamics Tunnel, and the Unitary Plan Wind Tunnel at NASA Langley, and the 12-FT Pressure Tunnel at NASA Ames. A dedicated system for the Langley 16-Foot Transonic Tunnel is scheduled to be used for the first time for a test in September. The advantages, limitations, and strategy of the technique as currently used in NASA wind tunnels are presented. Model deformation data are presented which illustrate the value of these measurements. Plans for further enhancements to the technique are presented.

  3. Ground deformation from ground-based SAR interferometry

    NASA Astrophysics Data System (ADS)

    Tarchi, Dario; Casagli, Nicola; Fortuny-Guasch, Joaquim; Guerri, Letizia; Antonello, Giuseppe; Leva, Davide

    An in-depth analysis of the last two images acquired by the ground-based interferometric synthetic aperture radar system installed on Stromboli before the 5 April 2003 explosion allowed us to detect the precursory signals of the explosion related to ground deformation. In particular, it was possible to estimate the exact time of the explosion through the time domain analysis of raw data from the radar acquisition. This was interrupted by a blackout that occurred a few seconds after the event. The explosion onset time corresponds to a clear change in the intensity of the backscattered energy, related to the dense volcanic plume emission from the Crater. In addiction, the use of a particular interferometric processing technique for the last two acquisitions, consisting of the selection of synthetic sub-apertures from the main ones and creating with these a sequence of interferograms with a higher temporal resolution, detected precursory deformations starting 2 min before the explosion. These observations indicate the occurrence of an elastic deformation of a centimeter amplitude that affected the volcanic edifice progressively from the Crater down to the Sciara del Fuoco depression.

  4. In-vivo spinal cord deformation in flexion

    NASA Astrophysics Data System (ADS)

    Yuan, Qing; Dougherty, Lawrence; Margulies, Susan S.

    1997-05-01

    Traumatic mechanical loading of the head-neck complex results cervical spinal cord injury when the distortion of the cord is sufficient to produce functional or structural failure of the cord's neural and/or vascular components. Characterizing cervical spinal cord deformation during physiological loading conditions is an important step to defining a comprehensive injury threshold associated with acute spinal cord injury. In this study, in vivo quasi- static deformation of the cervical spinal cord during flexion of the neck in human volunteers was measured using magnetic resonance (MR) imaging of motion with spatial modulation of magnetization (SPAMM). A custom-designed device was built to guide the motion of the neck and enhance more reproducibility. the SPAMM pulse sequence labeled the tissue with a series of parallel tagging lines. A single- shot gradient-recalled-echo sequence was used to acquire the mid-sagittal image of the cervical spine. A comparison of the tagged line pattern in each MR reference and deformed image pair revealed the distortion of the spinal cord. The results showed the cervical spinal cord elongates during head flexion. The elongation experienced by the spinal cord varies linearly with head flexion, with the posterior surface of the cord stretching more than the anterior surface. The maximal elongation of the cord is about 12 percent of its original length.

  5. Large Scale Deformation Monitoring and Atmospheric Removal in Mexico City

    NASA Astrophysics Data System (ADS)

    McCardle, Adrian; McCardel, Jim; Ramos, Fernanda Ledo G.

    2010-03-01

    Large scale, accurate measurement of non-linear ground movement is required for monitoring applications pertaining to groundwater extraction, oil and gas production, and carbon capture and storage. Mexico City experiences severe subsidence as high as 35 centimeters per year due to continued exploitation of groundwater. Such extreme ground deformation has caused damage to infrastructure and many areas of the city are now subjected to periodic flooding. Furthermore, subsidence rates change seasonally creating a non-linear deformation signature manifesting over an area larger than 30 x 30 kilometers. The geographical location and climate of Mexico City, coupled with aforementioned subsidence characteristics create unique challenges for repeat-pass InSAR processing: Firstly, Mexico City is a tropical highland and experiences an oceanic climate that leads to significant temporal de-correlation. Secondly, the large magnitude subsidence leads to phase aliasing over coherent targets, particularly for interferograms with large temporal separation. Lastly, the expansive deformation is spatially correlated on scales similar to the long-range atmosphere, complicating the separation of the two signals. This paper discusses the results from the application of traditional DInSAR techniques combined with Multi-temporal InSAR Network Analysis processing algorithms to accurately identify and measure displacement, specifically in light of the challenges peculiar to Mexico City. Multi-temporal InSAR Network Analysis techniques are used to identify non-linear displacement and remove atmospheric noise from 38 ENVISAT images that were acquired over Mexico City from 2002 to 2007.

  6. Evaluation of fingerprint deformation using optical coherence tomography

    NASA Astrophysics Data System (ADS)

    Gutierrez da Costa, Henrique S.; Maxey, Jessica R.; Silva, Luciano; Ellerbee, Audrey K.

    2014-02-01

    Biometric identification systems have important applications to privacy and security. The most widely used of these, print identification, is based on imaging patterns present in the fingers, hands and feet that are formed by the ridges, valleys and pores of the skin. Most modern print sensors acquire images of the finger when pressed against a sensor surface. Unfortunately, this pressure may result in deformations, characterized by changes in the sizes and relative distances of the print patterns, and such changes have been shown to negatively affect the performance of fingerprint identification algorithms. Optical coherence tomography (OCT) is a novel imaging technique that is capable of imaging the subsurface of biological tissue. Hence, OCT may be used to obtain images of subdermal skin structures from which one can extract an internal fingerprint. The internal fingerprint is very similar in structure to the commonly used external fingerprint and is of increasing interest in investigations of identify fraud. We proposed and tested metrics based on measurements calculated from external and internal fingerprints to evaluate the amount of deformation of the skin. Such metrics were used to test hypotheses about the differences of deformation between the internal and external images, variations with the type of finger and location inside the fingerprint.

  7. Volumetric Intraoperative Brain Deformation Compensation: Model Development and Phantom Validation

    PubMed Central

    DeLorenzo, Christine; Papademetris, Xenophon; Staib, Lawrence H.; Vives, Kenneth P.; Spencer, Dennis D.; Duncan, James S.

    2012-01-01

    During neurosurgery, nonrigid brain deformation may affect the reliability of tissue localization based on preoperative images. To provide accurate surgical guidance in these cases, preoperative images must be updated to reflect the intraoperative brain. This can be accomplished by warping these preoperative images using a biomechanical model. Due to the possible complexity of this deformation, intraoperative information is often required to guide the model solution. In this paper, a linear elastic model of the brain is developed to infer volumetric brain deformation associated with measured intraoperative cortical surface displacement. The developed model relies on known material properties of brain tissue, and does not require further knowledge about intraoperative conditions. To provide an initial estimation of volumetric model accuracy, as well as determine the model’s sensitivity to the specified material parameters and surface displacements, a realistic brain phantom was developed. Phantom results indicate that the linear elastic model significantly reduced localization error due to brain shift, from >16 mm to under 5 mm, on average. In addition, though in vivo quantitative validation is necessary, preliminary application of this approach to images acquired during neocortical epilepsy cases confirms the feasibility of applying the developed model to in vivo data. PMID:22562728

  8. Deformable registration of multi-modal data including rigid structures

    SciTech Connect

    Huesman, Ronald H.; Klein, Gregory J.; Kimdon, Joey A.; Kuo, Chaincy; Majumdar, Sharmila

    2003-05-02

    Multi-modality imaging studies are becoming more widely utilized in the analysis of medical data. Anatomical data from CT and MRI are useful for analyzing or further processing functional data from techniques such as PET and SPECT. When data are not acquired simultaneously, even when these data are acquired on a dual-imaging device using the same bed, motion can occur that requires registration between the reconstructed image volumes. As the human torso can allow non-rigid motion, this type of motion should be estimated and corrected. We report a deformation registration technique that utilizes rigid registration for bony structures, while allowing elastic transformation of soft tissue to more accurately register the entire image volume. The technique is applied to the registration of CT and MR images of the lumbar spine. First a global rigid registration is performed to approximately align features. Bony structures are then segmented from the CT data using semi-automated process, and bounding boxes for each vertebra are established. Each CT subvolume is then individually registered to the MRI data using a piece-wise rigid registration algorithm and a mutual information image similarity measure. The resulting set of rigid transformations allows for accurate registration of the parts of the CT and MRI data representing the vertebrae, but not the adjacent soft tissue. To align the soft tissue, a smoothly-varying deformation is computed using a thin platespline(TPS) algorithm. The TPS technique requires a sparse set of landmarks that are to be brought into correspondence. These landmarks are automatically obtained from the segmented data using simple edge-detection techniques and random sampling from the edge candidates. A smoothness parameter is also included in the TPS formulation for characterization of the stiffness of the soft tissue. Estimation of an appropriate stiffness factor is obtained iteratively by using the mutual information cost function on the result

  9. [Clinical cases of acquired coagulation inhibitors].

    PubMed

    Yamane, T; Hino, M; Ota, K; Akahori, M; Hirai, M; Inoue, T; Mugitani, A; Tatsumi, N

    2000-12-01

    The acquired coagulation factor inhibitors are classified into alloantibodies, which appear in association with supplementary treatment for congenital coagulation factor deficiency, and autoantibodies, which are spontaneously produced. We report here 2 cases of acquired factor VIII inhibitor and 1 case of factor V inhibitor. Case 1: A 52-year-old woman noted swelling of the right parotid region in March 1988. Though contrast examination was scheduled, she was admitted for detailed examination due to a markedly prolonged coagulation time. An APTT correction test suggested that decreased factor VIII activity was due to the presence of an inhibitor. Since antinuclear antibody and SS-A antibody were positive and infiltration by lymphocytes in the salivary gland acini in a lip biopsy specimen was detected, Sjögren's syndrome was diagnosed. Case 2: A 33-year-old woman had normal delivery of her second child in February 1998. In June 1998, she suffered slight contusion in the left lower limb. The affected site became swollen and painful, making walking difficult. Since both upper limbs became markedly swollen after 1 week, she visited our hospital. Prolonged APTT and a marked decrease in factor VIII activity were observed. Factor VIII inhibitor titer was high at 19 Bethesda units. Case 3: A 64-year-old man had had asymptomatic macroscopic hematuria since the beginning of August 1998 but was placed under observation since no abnormal findings were observed on various imaging tests. However, he was admitted to Osaka City General Medical Center because of vesicular tamponade. Factor V activity was markedly decreased to 1.0%. PT correction test suggested that decreased factor V activity was due to the presence of an inhibitor. The underlying disease could not be determined in this case. In patients with acquired coagulation inhibitors, bleeding symptoms are reported to be mild in many cases, and severe bleeding is rare. However, cases of death without severe bleeding or

  10. Preferred orientation in experimentally deformed stishovite: implications for deformation mechanisms

    DOE PAGES

    Kaercher, Pamela M.; Zepeda-Alarcon, Eloisa; Prakapenka, Vitali B.; ...

    2014-11-07

    Although the crystal structure of the high pressure SiO2 polymorph stishovite has been studied in detail, little is known about the development of crystallographic preferred orientation (CPO) during deformation in stishovite. Insight into CPO and associated deformation mechanics of stishovite would provide important information for understanding subduction of quartz-bearing crustal rocks into the mantle. To study CPO development, we converted a natural sample of flint to stishovite in a laser heated diamond anvil cell and compressed the stishovite aggregate up to 38 GPa. We collected diffraction patterns in radial geometry to examine in situ development of crystallographic preferred orientation andmore » find that (001) poles preferentially align with the compression direction. Viscoplastic self-consistent modeling suggests the most likely slip systems at high pressure and ambient temperature are pyramidal and basal slip.« less

  11. Preferred orientation in experimentally deformed stishovite: implications for deformation mechanisms

    NASA Astrophysics Data System (ADS)

    Kaercher, Pamela M.; Zepeda-Alarcon, Eloisa; Prakapenka, Vitali B.; Kanitpanyacharoen, Waruntorn; Smith, Jesse S.; Sinogeikin, Stanislav; Wenk, Hans-Rudolf

    2015-04-01

    Although the crystal structure of the high-pressure SiO2 polymorph stishovite has been studied in detail, little is known about the development of crystallographic preferred orientation (CPO) during deformation in stishovite. Insight into CPO and associated deformation mechanics of stishovite would provide important information for understanding subduction of quartz-bearing crustal rocks into the mantle. To study CPO development, we converted a natural sample of flint to stishovite in a laser-heated diamond anvil cell and compressed the stishovite aggregate up to 38 GPa. We collected diffraction patterns in radial geometry to examine in situ development of crystallographic preferred orientation and find that (001) poles preferentially align with the compression direction. Viscoplastic self-consistent modeling suggests the most likely slip systems at high pressure and ambient temperature are pyramidal and basal slip.

  12. Highly deformable bones: unusual deformation mechanisms of seahorse armor.

    PubMed

    Porter, Michael M; Novitskaya, Ekaterina; Castro-Ceseña, Ana Bertha; Meyers, Marc A; McKittrick, Joanna

    2013-06-01

    Multifunctional materials and devices found in nature serve as inspiration for advanced synthetic materials, structures and robotics. Here, we elucidate the architecture and unusual deformation mechanisms of seahorse tails that provide prehension as well as protection against predators. The seahorse tail is composed of subdermal bony plates arranged in articulating ring-like segments that overlap for controlled ventral bending and twisting. The bony plates are highly deformable materials designed to slide past one another and buckle when compressed. This complex plate and segment motion, along with the unique hardness distribution and structural hierarchy of each plate, provide seahorses with joint flexibility while shielding them against impact and crushing. Mimicking seahorse armor may lead to novel bio-inspired technologies, such as flexible armor, fracture-resistant structures or prehensile robotics.

  13. Preferred orientation in experimentally deformed stishovite: implications for deformation mechanisms

    SciTech Connect

    Kaercher, Pamela M.; Zepeda-Alarcon, Eloisa; Prakapenka, Vitali B.; Kanitpanyacharoen, Waruntorn; Smith, Jesse S.; Sinogeikin, Stanislav; Wenk, Hans-Rudolf

    2014-11-07

    Although the crystal structure of the high pressure SiO2 polymorph stishovite has been studied in detail, little is known about the development of crystallographic preferred orientation (CPO) during deformation in stishovite. Insight into CPO and associated deformation mechanics of stishovite would provide important information for understanding subduction of quartz-bearing crustal rocks into the mantle. To study CPO development, we converted a natural sample of flint to stishovite in a laser heated diamond anvil cell and compressed the stishovite aggregate up to 38 GPa. We collected diffraction patterns in radial geometry to examine in situ development of crystallographic preferred orientation and find that (001) poles preferentially align with the compression direction. Viscoplastic self-consistent modeling suggests the most likely slip systems at high pressure and ambient temperature are pyramidal and basal slip.

  14. SU-E-J-218: Novel Validation Paradigm of MRI to CT Deformation of Prostate

    SciTech Connect

    Padgett, K; Pirozzi, S; Nelson, A; Piper, J; Horvat, M; Stoyanova, R; Dogan, N; Pollack, A

    2015-06-15

    Purpose: Deformable registration algorithms are inherently difficult to characterize in the multi-modality setting due to a significant differences in the characteristics of the different modalities (CT and MRI) as well as tissue deformations. We present a unique paradigm where this is overcome by utilizing a planning-MRI acquired within an hour of the planning-CT serving as a surrogate for quantifying MRI to CT deformation by eliminating the issues of multi-modality comparisons. Methods: For nine subjects, T2 fast-spin-echo images were acquired at two different time points, the first several weeks prior to planning (diagnostic-MRI) and the second on the same day as the planning-CT (planning-MRI). Significant effort in patient positioning and bowel/bladder preparation was undertaken to minimize distortion of the prostate in all datasets. The diagnostic-MRI was rigidly and deformably aligned to the planning-CT utilizing a commercially available deformable registration algorithm synthesized from local registrations. Additionally, the quality of rigid alignment was ranked by an imaging physicist. The distances between corresponding anatomical landmarks on rigid and deformed registrations (diagnostic-MR to planning-CT) were evaluated. Results: It was discovered that in cases where the rigid registration was of acceptable quality the deformable registration didn’t improve the alignment, this was true of all metrics employed. If the analysis is separated into cases where the rigid alignment was ranked as unacceptable the deformable registration significantly improved the alignment, 4.62mm residual error in landmarks as compared to 5.72mm residual error in rigid alignments with a p-value of 0.0008. Conclusion: This paradigm provides an ideal testing ground for MR to CT deformable registration algorithms by allowing for inter-modality comparisons of multi-modality registrations. Consistent positioning, bowel and bladder preparation may Result in higher quality rigid

  15. Clusterization and quadrupole deformation in nuclei

    SciTech Connect

    Cseh, J.; Algora, A.; Antonenko, N. V.; Jolos, R. V.; Scheid, W.; Darai, J.; Hess, P. O.

    2006-04-26

    We study the interrelation of the clusterization and quadrupole deformation of atomic nuclei, by applying cluster models. Both the energetic stability and the exclusion principle is investigated. Special attention is paid to the relative orientations of deformed clusters.

  16. ACECARD. Acquire CoOmmodities Easily Card

    SciTech Connect

    Soler, E.E.

    1996-09-01

    Acquire Commodities Easily Card (AceCard) provides an automated end-user method to distribute company credit card charges to internal charge numbers. AceCard will allow cardholders to record card purchases in an on-line order log, enter multiple account distributions per order that can be posted to the General Ledger, track orders, and receipt information, and provide a variety of cardholder and administrative reports. Please note: Customers must contact Ed Soler (423)-576-6151, Lockheed Martin Energy Systems, for help with the installation of the package. The fee for this installation help will be coordinated by the customer and Lockheed Martin and is in addition to cost of the package from ESTSC. Customers should contact Sandy Presley (423)-576-4708 for user help.

  17. Acquire CoOmmodities Easily Card

    SciTech Connect

    Soler, E. E.

    1998-05-29

    Acquire Commodities Easily Card (AceCard) provides an automated end-user method to distribute company credit card charges to internal charge numbers. AceCard will allow cardholders to record card purchases in an on-line order log, enter multiple account distributions per order that can be posted to the General Ledger, track orders, and receipt information, and provide a variety of cardholder and administrative reports. Please note: Customers must contact Ed Soler (423)-576-6151, Lockheed Martin Energy Systems, for help with the installation of the package. The fee for this installation help will be coordinated by the customer and Lockheed Martin and is in addition to cost of the package from ESTSC. Customers should contact Sandy Presley (423)-576-4708 for user help.

  18. Stereotypic movement disorder after acquired brain injury.

    PubMed

    McGrath, Cynthia M; Kennedy, Richard E; Hoye, Wayne; Yablon, Stuart A

    2002-05-01

    Stereotypic movement disorder (SMD) consists of repetitive, non-functional motor behaviour that interferes with daily living or causes injury to the person. It is most often described in patients with mental retardation. However, recent evidence indicates that this condition is common among otherwise normal individuals. This case study describes a patient with new-onset SMD occurring after subdural haematoma and brain injury. SMD has rarely been reported after acquired brain injury, and none have documented successful treatment. The current psychiatric literature regarding neurochemistry, neuroanatomy, and treatment of SMD are reviewed with particular application to one patient. Treatment options include serotonin re-uptake inhibitors, opioid antagonists and dopamine antagonists. SMD has been under-appreciated in intellectually normal individuals, and may also be unrecognized after brain injury. Further investigation is needed in this area, which may benefit other individuals with SMD as well.

  19. Innate and acquired bacteriophage-mediated immunity

    PubMed Central

    Barr, Jeremy J.; Youle, Merry; Rohwer, Forest

    2013-01-01

    We recently described a novel, non-host-derived, phage-mediated immunity active at mucosal surfaces, the main site of pathogen entry in metazoans. In that work, we showed that phage T4 adheres to mucus glycoproteins via immunoglobulin-like domains displayed on its capsid. This adherence positions the phage in mucus surfaces where they are more likely to encounter and kill bacteria, thereby benefiting both the phage and its metazoan host. We presented this phage-metazoan symbiosis based on an exclusively lytic model of phage infection. Here we extend our bacteriophage adherence to mucus (BAM) model to consider the undoubtedly more complex dynamics in vivo. We hypothesize how mucus-adherent phages, both lytic and temperate, might impact the commensal microbiota as well as protect the metazoan epithelium from bacterial invasion. We suggest that BAM may provide both an innate and an acquired antimicrobial immunity. PMID:24228227

  20. Acquired immunodeficiency syndrome and health care professionals.

    PubMed

    Menon, V; Bharucha, K

    1994-01-01

    As health care professionals, we face a grave risk of acquiring HIV infection in the course of our work. But how many of us really know the precautions to be applied in the hospital set up in dealing with HIV infected patients? A knowledge, attitude and practice (KAP) study was conducted in Pune hospitals to assess the current status. Among the results 65% servants had not heard of AIDS, 85% nursing staff did not apply the Universal Safety Precautions (USP) approach, 13.5% resident thought that the HIV was not transmitted by blood, 30% consultants would avoid contact with an HIV positive patient. This study has shown that definite lacunae exist in knowledge specific to the particular population in question. A proposal for an education programme which is target specific and one of constant renewal is sought.

  1. Signal regulators of systemic acquired resistance

    PubMed Central

    Gao, Qing-Ming; Zhu, Shifeng; Kachroo, Pradeep; Kachroo, Aardra

    2015-01-01

    Salicylic acid (SA) is an important phytohormone that plays a vital role in a number of physiological responses, including plant defense. The last two decades have witnessed a number of breakthroughs related to biosynthesis, transport, perception and signaling mediated by SA. These findings demonstrate that SA plays a crictical role in both local and systemic defense responses. Systemic acquired resistance (SAR) is one such SA-dependent response. SAR is a long distance signaling mechanism that provides broad spectrum and long-lasting resistance to secondary infections throughout the plant. This unique feature makes SAR a highly desirable trait in crop production. This review summarizes the recent advances in the role of SA in SAR and discusses its relationship to other SAR inducers. PMID:25918514

  2. Acquired Localized Hypertrichosis Induced by Rivastigmine

    PubMed Central

    Imbernón-Moya, Adrian; Podlipnik, Sebastian; Burgos, Fernando; Vargas-Laguna, Elena; Aguilar-Martínez, Antonio; Fernández-Cogolludo, Eva; Gallego-Valdes, Miguel Angel

    2016-01-01

    Hypertrichosis is the excessive hair growth in any area of the skin surface. Acquired localized hypertrichosis may be secondary to multiple causes and there is a secondary form due to several drugs, which is usually reversible with discontinuation of the causative agent. Rivastigmine is a reversible and competitive inhibitor of acetylcholinesterase and butyrylcholinesterase used for symptomatic treatment of Alzheimer dementia and Parkinson's disease. It has an adequate safety profile and cutaneous side effects are unusual. Irritant contact dermatitis, allergic dermatitis, baboon syndrome, and cutaneous rash due to rivastigmine have been reported. We report on a Caucasian 80-year-old male with personal history of Alzheimer's disease. The patient started therapy with oral rivastigmine one month prior to clinical presentation of localized hypertrichosis on both forearms. Norgalanthamine has been shown to promote hair growth activity via the proliferation of dermal papilla. Acetylcholinesterase inhibitors can induce hair growth. PMID:27073702

  3. Treatment of the acquired von Willebrand syndrome.

    PubMed

    Budde, Ulrich; Scheppenheim, Sonja; Dittmer, Rita

    2015-12-01

    Acquired von Willebrand syndrome (aVWS) accounts for 22% of patients with abnormal von Willebrand factor. Most patients with known pathophysiological mechanisms suffer from cardiovascular, myeloproliferative and lymphoproliferative disorders. Less frequent associations are of autoimmune origin, due to hyperfibrinolysis, adsorption to tumor cells, reduced synthesis and prolonged circulation. The mechanisms leading to aVWS is hitherto not known in patients with liver and kidney diseases, drug use, glycogen storage disease, virus infections and at least 18 other disease entities. Diagnosis is complicated by the battery of tests needed, and their inherent rather low sensitivity and specificity for aVWS. Thus, even in acute bleeding situations it may take days until a firm diagnosis is settled and specific therapies can be initiated. The main aim is to shed more light onto this, compared with inherited von Willebrand disease, rare disease which affects at least 2-3% of the older population.

  4. Intensive care unit-acquired weakness.

    PubMed

    Horn, J; Hermans, G

    2017-01-01

    When critically ill, a severe weakness of the limbs and respiratory muscles often develops with a prolonged stay in the intensive care unit (ICU), a condition vaguely termed intensive care unit-acquired weakness (ICUAW). Many of these patients have serious nerve and muscle injury. This syndrome is most often seen in surviving critically ill patients with sepsis or extensive inflammatory response which results in increased duration of mechanical ventilation and hospital length of stay. Patients with ICUAW often do not fully recover and the disability will seriously impact on their quality of life. In this chapter we discuss the current knowledge on the pathophysiology and risk factors of ICUAW. Tools to diagnose ICUAW, how to separate ICUAW from other disorders, and which possible treatment strategies can be employed are also described. ICUAW is finally receiving the attention it deserves and the expectation is that it can be better understood and prevented.

  5. Severe acquired anaemia in Africa: new concepts.

    PubMed

    van Hensbroek, Michael B; Jonker, Femkje; Bates, Imelda

    2011-09-01

    Severe anaemia is common in Africa. It has a high mortality and particularly affects young children and pregnant women. Recent research provides new insights into the mechanisms and causes of severe acquired anaemia and overturns accepted dogma. Deficiencies of vitamin B12 and vitamin A, but not of iron or folic acid, are associated with severe anaemia. Bacterial infections and, in very young children, hookworm infections are also common in severe anaemia. Irrespective of the aetiology, the mechanism causing severe anaemia is often red cell production failure. Severe anaemia in Africa is therefore a complex multi-factorial syndrome, which, even in an individual patient, is unlikely to be amenable to a single intervention. Policies and practices concerning anaemia diagnosis, treatment and prevention need to be substantially revised if we are to make a significant impact on the huge burden of severe anaemia in Africa.

  6. Acquiring case adaptation knowledge: A hybrid approach

    SciTech Connect

    Leake, D.B.; Kinley, A.; Wilson, D.

    1996-12-31

    The ability of case-based reasoning (CBR) systems to apply cases to novel situations depends on their case adaptation knowledge. However, endowing CBR systems with adequate adaptation knowledge has proven to be a very difficult task. This paper describes a hybrid method for performing case adaptation, using a combination of rule-based and case-based reasoning. It shows how this approach provides a framework for acquiring flexible adaptation knowledge from experiences with autonomous adaptation and suggests its potential as a basis for acquisition of adaptation knowledge from interactive user guidance. It also presents initial experimental results examining the benefits of the approach and comparing the relative contributions of case learning and adaptation learning to reasoning performance.

  7. Acquired immunodeficiency syndrome: Ga-67 citrate imaging

    SciTech Connect

    Woolfenden, J.M.; Carrasquillo, J.A.; Larson, S.M.; Simmons, J.T.; Masur, H.; Smith, P.D.; Shelhamer, J.H.; Ognibene, F.P.

    1987-02-01

    All gallium-67 citrate scans obtained in patients with acquired immunodeficiency syndrome (AIDS) at the Clinical Center, National Institutes of Health (Bethesda, Md.) were retrospectively analyzed and correlated with the results of bronchoscopy, chest radiography, and endoscopy. There were 164 scans of 95 patients. Twenty scans were from patients with Pneumocystis carinii pneumonia; 19 were abnormal, for a sensitivity of 95%. Ga-67 uptake tended to be less in patients receiving therapy for P. carinii pneumonia. Chest radiographs were normal at least initially in three patients with abnormal scans and P. carinii pneumonia. Unusually prominent colonic activity was associated with infection in some patients. No lesions of Kaposi sarcoma showed tracer uptake. Gallium scanning is useful for detecting P. carinii pneumonia and other opportunistic infections in patients with AIDS, but it is not useful for localizing Kaposi sarcoma.

  8. Deformed special relativity and deformed symmetries in a canonical framework

    SciTech Connect

    Ghosh, Subir; Pal, Probir

    2007-05-15

    In this paper we have studied the nature of kinematical and dynamical laws in {kappa}-Minkowski spacetime from a new perspective: the canonical phase space approach. We discuss a particular form of {kappa}-Minkowski phase space algebra that yields the {kappa}-extended finite Lorentz transformations derived in [D. Kimberly, J. Magueijo, and J. Medeiros, Phys. Rev. D 70, 084007 (2004).]. This is a particular form of a deformed special relativity model that admits a modified energy-momentum dispersion law as well as noncommutative {kappa}-Minkowski phase space. We show that this system can be completely mapped to a set of phase space variables that obey canonical (and not {kappa}-Minkowski) phase space algebra and special relativity Lorentz transformation (and not {kappa}-extended Lorentz transformation). The complete set of deformed symmetry generators are constructed that obeys an unmodified closed algebra but induce deformations in the symmetry transformations of the physical {kappa}-Minkowski phase space variables. Furthermore, we demonstrate the usefulness and simplicity of this approach through a number of phenomenological applications both in classical and quantum mechanics. We also construct a Lagrangian for the {kappa}-particle.

  9. Guidelines for prevention of hospital acquired infections

    PubMed Central

    Mehta, Yatin; Gupta, Abhinav; Todi, Subhash; Myatra, SN; Samaddar, D. P.; Patil, Vijaya; Bhattacharya, Pradip Kumar; Ramasubban, Suresh

    2014-01-01

    These guidelines, written for clinicians, contains evidence-based recommendations for the prevention of hospital acquired infections Hospital acquired infections are a major cause of mortality and morbidity and provide challenge to clinicians. Measures of infection control include identifying patients at risk of nosocomial infections, observing hand hygiene, following standard precautions to reduce transmission and strategies to reduce VAP, CR-BSI, CAUTI. Environmental factors and architectural lay out also need to be emphasized upon. Infection prevention in special subsets of patients - burns patients, include identifying sources of organism, identification of organisms, isolation if required, antibiotic prophylaxis to be used selectively, early removal of necrotic tissue, prevention of tetanus, early nutrition and surveillance. Immunodeficient and Transplant recipients are at a higher risk of opportunistic infections. The post tranplant timetable is divided into three time periods for determining risk of infections. Room ventilation, cleaning and decontamination, protective clothing with care regarding food requires special consideration. Monitoring and Surveillance are prioritized depending upon the needs. Designated infection control teams should supervise the process and help in collection and compilation of data. Antibiotic Stewardship Recommendations include constituting a team, close coordination between teams, audit, formulary restriction, de-escalation, optimizing dosing, active use of information technology among other measure. The recommendations in these guidelines are intended to support, and not replace, good clinical judgment. The recommendations are rated by a letter that indicates the strength of the recommendation and a Roman numeral that indicates the quality of evidence supporting the recommendation, so that readers can ascertain how best to apply the recommendations in their practice environments. PMID:24701065

  10. Community-Acquired Pneumonia in Latin America.

    PubMed

    Iannella, Hernán A; Luna, Carlos M

    2016-12-01

    Community-acquired pneumonia (CAP) is associated with significant morbidity and mortality in Latin America and the Caribbean (LAC) region. Poverty, socioeconomic factors, and malnutrition influence the incidence and outcome of CAP in LAC. In LAC, Streptococcus pneumoniae is the most frequent microorganism responsible for CAP, (incidence: 24-78%); the incidence of atypical microorganisms is similar to other regions of the world. Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) is a growing problem in the LAC region, with the Caribbean being the second most affected area worldwide after Sub-Saharan Africa. Pneumococcal pneumonia remains the most common cause of CAP in HIV-infected patients, but Pneumocystis jirovecii and tuberculosis (TB) are also common in this population. The heterogeneity of the health care systems and social inequity between different countries in LAC, and even between different settings inside the same country, is a difficult issue. TB, including multidrug-resistant TB, is several times more common in South American and Central American countries compared with North America. Furthermore, hantaviruses circulating in the Americas (new world hantaviruses) generate a severe respiratory disease called hantavirus pulmonary syndrome, with an associated mortality as high as 50%. More than 30 hantaviruses have been reported in the Western Hemisphere, with more frequent cases registered in the southern cone (Argentina, Chile, Uruguay, Paraguay, Bolivia, and Brazil). Respiratory viruses (particularly influenza) remain an important cause of morbidity and mortality, particularly in the elderly. Low rates of vaccination (against influenza as well as pneumococcus) may heighten the risk of these infections in low- and middle-income countries.

  11. The use of expanded polytetrafluoroethylene in depressed deformities of the face

    PubMed Central

    Liu, Xiaowei; Zhang, Yiming; Wang, Shaoliang; Lei, Zeyuan; Li, Xiang; Fan, Dongli

    2016-01-01

    Expanded polytetrafluoroethylene (ePTFE) has been extensively used for facial soft tissue augmentation procedures, and is regarded as safe and reliable and suitable as a permanent implant. This implant is generally used in the lower third of the face for lips filling, nasal augmentation, nasolabial folds and chin augmentation, and rarely for congenital or acquired depressed deformities of the face. The aim of the present study was to assess the effects of ePTFE in congenital or acquired depressed deformities of the face. From September, 2008 to January, 2014, 26 patients were implanted with the material ePTFE to correct depressed deformities of the face. The average age at operation was 23.2 years, with a range of 17–45 years. The depressed deformities were lateralized. The follow-up period was 6–18 months (average 9 months). The etiologies of the depressed deformities included stable hemifacial atrophy (3 cases), craniofacial microsomia (13 cases), bony depression after trauma (8 cases), and other unclear reasons (2 cases). The operations were performed under local anesthesia. ePTFE was inserted in different tissue planes that varied among the different subanatomical areas in the face: beneath the superficial temporal fascia in the temporal area, and on the surface of the superficial musculoaponeurotic system in the zygomatic area, cheek and mandibular area. All of the patients were followed up. Most of the patients [25 of 26 patients (96.2%)] were satisfied with the results, while 1 patient (3.8%) was not satisfied for incomplete correction of the depressed deformity. In conclusion, aside from lipofilling and a free flap transfer, the results showed that ePTFE was an alternative treatment for facial depressed deformity. PMID:27882130

  12. Deformation of noncommutative quantum mechanics

    NASA Astrophysics Data System (ADS)

    Jiang, Jian-Jian; Chowdhury, S. Hasibul Hassan

    2016-09-01

    In this paper, the Lie group GNC α , β , γ , of which the kinematical symmetry group GNC of noncommutative quantum mechanics (NCQM) is a special case due to fixed nonzero α, β, and γ, is three-parameter deformation quantized using the method suggested by Ballesteros and Musso [J. Phys. A: Math. Theor. 46, 195203 (2013)]. A certain family of QUE algebras, corresponding to GNC α , β , γ with two of the deformation parameters approaching zero, is found to be in agreement with the existing results of the literature on quantum Heisenberg group. Finally, we dualize the underlying QUE algebra to obtain an expression for the underlying star-product between smooth functions on GNC α , β , γ .

  13. Variational approach and deformed derivatives

    NASA Astrophysics Data System (ADS)

    Weberszpil, J.; Helayël-Neto, J. A.

    2016-05-01

    Recently, we have demonstrated that there exists a possible relationship between q-deformed algebras in two different contexts of Statistical Mechanics, namely, the Tsallis' framework and the Kaniadakis' scenario, with a local form of fractional-derivative operators for fractal media, the so-called Hausdorff derivatives, mapped into a continuous medium with a fractal measure. Here, in this paper, we present an extension of the traditional calculus of variations for systems containing deformed-derivatives embedded into the Lagrangian and the Lagrangian densities for classical and field systems. The results extend the classical Euler-Lagrange equations and the Hamiltonian formalism. The resulting dynamical equations seem to be compatible with those found in the literature, specially with mass-dependent and with nonlinear equations for systems in classical and quantum mechanics. Examples are presented to illustrate applications of the formulation. Also, the conserved ​Noether current is worked out.

  14. Preschoolers Acquire General Knowledge by Sharing in Pretense

    ERIC Educational Resources Information Center

    Sutherland, Shelbie L.; Friedman, Ori

    2012-01-01

    Children acquire general knowledge about many kinds of things, but there are few known means by which this knowledge is acquired. In this article, it is proposed that children acquire generic knowledge by sharing in pretend play. In Experiment 1, twenty-two 3- to 4-year-olds watched pretense in which a puppet represented a "nerp" (an unfamiliar…

  15. 19 CFR 148.38 - Sale of articles acquired abroad.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Sale of articles acquired abroad. 148.38 Section... § 148.38 Sale of articles acquired abroad. An article brought in under the $800 or $1,600 exemption for articles acquired abroad for personal or household use and subsequently sold is not dutiable or subject...

  16. 19 CFR 148.38 - Sale of articles acquired abroad.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Sale of articles acquired abroad. 148.38 Section... § 148.38 Sale of articles acquired abroad. An article brought in under the $800 or $1,600 exemption for articles acquired abroad for personal or household use and subsequently sold is not dutiable or subject...

  17. 19 CFR 148.38 - Sale of articles acquired abroad.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Sale of articles acquired abroad. 148.38 Section... § 148.38 Sale of articles acquired abroad. An article brought in under the $800 or $1,600 exemption for articles acquired abroad for personal or household use and subsequently sold is not dutiable or subject...

  18. 19 CFR 148.38 - Sale of articles acquired abroad.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Sale of articles acquired abroad. 148.38 Section... § 148.38 Sale of articles acquired abroad. An article brought in under the $800 or $1,600 exemption for articles acquired abroad for personal or household use and subsequently sold is not dutiable or subject...

  19. 7 CFR 770.8 - Use of acquired land.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 7 2014-01-01 2014-01-01 false Use of acquired land. 770.8 Section 770.8 Agriculture... SPECIAL PROGRAMS INDIAN TRIBAL LAND ACQUISITION LOANS § 770.8 Use of acquired land. (a) General. Subject to § 770.5(d) land acquired with loan funds, or other property serving as the security for a...

  20. 43 CFR 4110.1-1 - Acquired lands.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Acquired lands. 4110.1-1 Section 4110.1-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... and Preference § 4110.1-1 Acquired lands. Where lands have been acquired by the Bureau of...

  1. 30 CFR 879.14 - Management of acquired land.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Management of acquired land. 879.14 Section 879... ABANDONED MINE LAND RECLAMATION ACQUISITION, MANAGEMENT, AND DISPOSITION OF LANDS AND WATER § 879.14 Management of acquired land. Land acquired under this part may be used for any lawful purpose that...

  2. 7 CFR 770.8 - Use of acquired land.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 7 2013-01-01 2013-01-01 false Use of acquired land. 770.8 Section 770.8 Agriculture... SPECIAL PROGRAMS INDIAN TRIBAL LAND ACQUISITION LOANS § 770.8 Use of acquired land. (a) General. Subject to § 770.5(d) land acquired with loan funds, or other property serving as the security for a...

  3. 43 CFR 4110.1-1 - Acquired lands.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Acquired lands. 4110.1-1 Section 4110.1-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... and Preference § 4110.1-1 Acquired lands. Where lands have been acquired by the Bureau of...

  4. 43 CFR 4110.1-1 - Acquired lands.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Acquired lands. 4110.1-1 Section 4110.1-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... and Preference § 4110.1-1 Acquired lands. Where lands have been acquired by the Bureau of...

  5. 30 CFR 879.14 - Management of acquired land.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Management of acquired land. 879.14 Section 879... ABANDONED MINE LAND RECLAMATION ACQUISITION, MANAGEMENT, AND DISPOSITION OF LANDS AND WATER § 879.14 Management of acquired land. Land acquired under this part may be used for any lawful purpose that...

  6. 7 CFR 770.8 - Use of acquired land.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 7 2012-01-01 2012-01-01 false Use of acquired land. 770.8 Section 770.8 Agriculture... SPECIAL PROGRAMS INDIAN TRIBAL LAND ACQUISITION LOANS § 770.8 Use of acquired land. (a) General. Subject to § 770.5(d) land acquired with loan funds, or other property serving as the security for a...

  7. 43 CFR 4110.1-1 - Acquired lands.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Acquired lands. 4110.1-1 Section 4110.1-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... and Preference § 4110.1-1 Acquired lands. Where lands have been acquired by the Bureau of...

  8. 30 CFR 879.14 - Management of acquired land.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Management of acquired land. 879.14 Section 879... ABANDONED MINE LAND RECLAMATION ACQUISITION, MANAGEMENT, AND DISPOSITION OF LANDS AND WATER § 879.14 Management of acquired land. Land acquired under this part may be used for any lawful purpose that...

  9. 30 CFR 879.14 - Management of acquired land.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Management of acquired land. 879.14 Section 879... ABANDONED MINE LAND RECLAMATION ACQUISITION, MANAGEMENT, AND DISPOSITION OF LANDS AND WATER § 879.14 Management of acquired land. Land acquired under this part may be used for any lawful purpose that...

  10. Deformation processes in forging ceramics

    NASA Technical Reports Server (NTRS)

    Cannon, R. M.; Rhodes, W. H.

    1972-01-01

    The deformation processes involved in the forging of refractory ceramic oxides were investigated. A combination of mechanical testing and forging are utilized to investigate both the flow and fracture processes involved. An additional hemisphere forging was done which failed prematurely. Analysis and comparison with available fracture data for AL2O3 indicated possible causes of the failure. Examination of previous forgings indicated an increase in grain boundary cavitation with increasing strain.

  11. Graviton resonances on deformed branes

    NASA Astrophysics Data System (ADS)

    Cruz, W. T.; Gomes, A. R.; Almeida, C. A. S.

    2011-11-01

    Plane-wave solutions of Schrödinger-like equations obtained from the metric perturbations in 5D braneworld scenarios can present resonant modes. The search for those structures is important because they can provide us with massive modes with not suppressed couplings with the membrane. We propose in this paper the study of graviton Kaluza-Klein spectrum in a special kind of membrane that possesses internal structure. The interest in the study of these deformed defects is due to the fact that they have a richer internal structure that has implications in the matter energy density along the extra dimensions and this produces a space-time background whose curvature has a splitting, if compared to the usual kink-like models. Such models arise from (4, 1)-branes constructed with one scalar field coupled with gravity where we find two-kink solutions from deformations of a phi4 potential. The main objective of this work is to observe the effects of deformation process in the resonant modes as well as in the coupling between the graviton massive modes and the brane.

  12. Remagnetisation of a rock analogue during experimental triaxial deformation

    NASA Astrophysics Data System (ADS)

    Borradaile, Graham J.

    1994-05-01

    Synthetic specimens containing pseudo-single-domain magnetite were given a univectorial, anhysteretic remanent magnetisation. They were deformed in a ductile manner at room temperature under a confining pressure of 150 MPa (1.5 kbar). The strain rate was 10 -5 s -1 and the maximum strain achieved was 23% shortening. A weak (0.035 mT) magnetic field was present in the pressure vessel during deformation. Hydrostatic compaction alone produced pressure demagnetisation of low-coercivity components of remanence but did not change remanence directions. Macroscopic differential stress was needed to deform the specimens, and this also permitted syndeformational remagnetisation for values of more than 20 MPa (200 bars). This added new components of piezo-remanent magnetisation (PRM) approximately parallel to the direction of the magnetic field in the pressure vessel. They were acquired in all coercivity intervals but the largest components were added below 35 mT. The final remanence orientation and its spatial distribution of vector components were dictated by the relative orientations of the remagnetising field and the initial remanence. PRM contributions almost completely masked the changes related to strain-induced grain rotation at these low strains. The directions of the externally imposed stress-strain axes may not significantly influence the direction of new remanence components. PRM acquisition occurs when differential stress exceeds a threshold value that probably depends on the previous stress-history of the magnetite grains. In part, this may explain the origin of syntectonic remagnetisation in some naturally deformed rocks where the remanence is not reset by recrystallisation, or thermal or chemical processes.

  13. Improving the quality of radiographic images acquired with conical radiation beams through divergence correction and filtering

    NASA Astrophysics Data System (ADS)

    Silvani, M. I.; Almeida, G. L.; Latini, R. M.; Bellido, A. V. B.; Souza, E. S.; Lopes, R. T.

    2015-07-01

    Earlier works have shown the feasibility to correct the deformation of the attenuation map in radiographs acquired with conical radiation beams provided that the inspected object could be expressed into analytical geometry terms. This correction reduces the contribution of the main object in the radiograph, allowing thus the visualization of its otherwise concealed heterogeneities. However, the non-punctual character of the source demanded a cumbersome trial-and-error approach in order to determine the proper correction parameters for the algorithm. Within this frame, this work addresses the improvement of radiographs of specially tailored test-objects acquired with a conical beam through correction of its divergence by using the information contained in the image itself. The corrected images have afterwards undergone a filtration in the frequency domain aiming at the reduction of statistical fluctuation and noise by using a 2D Fourier transform. All radiographs have been acquired using 165Dy and 198Au gamma-ray sources produced at the Argonauta research reactor in Institutode Engenharia Nuclear - CNEN, and an X-ray sensitive imaging plate as detector. The processed images exhibit features otherwise invisible in the original ones. Their processing by conventional histogram equalization carried out for comparison purposes did not succeed to detect those features.

  14. Integrable Deformations of T -Dual σ Models

    NASA Astrophysics Data System (ADS)

    Borsato, Riccardo; Wulff, Linus

    2016-12-01

    We present a method to deform (generically non-Abelian) T duals of two-dimensional σ models, which preserves classical integrability. The deformed models are identified by a linear operator ω on the dualized subalgebra, which satisfies the 2-cocycle condition. We prove that the so-called homogeneous Yang-Baxter deformations are equivalent, via a field redefinition, to our deformed models when ω is invertible. We explain the details for deformations of T duals of principal chiral models, and present the corresponding generalization to the case of supercoset models.

  15. Accidental degeneracies in nonlinear quantum deformed systems

    NASA Astrophysics Data System (ADS)

    Aleixo, A. N. F.; Balantekin, A. B.

    2011-09-01

    We construct a multi-parameter nonlinear deformed algebra for quantum confined systems that includes many other deformed models as particular cases. We demonstrate that such systems exhibit the property of accidental pairwise energy level degeneracies. We also study, as a special case of our multi-parameter deformation formalism, the extension of the Tamm-Dancoff cutoff deformed oscillator and the occurrence of accidental pairwise degeneracy in the energy levels of the deformed system. As an application, we discuss the case of a trigonometric Rosen-Morse potential, which is successfully used in models for quantum confined systems, ranging from electrons in quantum dots to quarks in hadrons.

  16. Automated registration of large deformations for adaptive radiation therapy of prostate cancer

    SciTech Connect

    Godley, Andrew; Ahunbay, Ergun; Peng Cheng; Li, X. Allen

    2009-04-15

    Available deformable registration methods are often inaccurate over large organ variation encountered, for example, in the rectum and bladder. The authors developed a novel approach to accurately and effectively register large deformations in the prostate region for adaptive radiation therapy. A software tool combining a fast symmetric demons algorithm and the use of masks was developed in C++ based on ITK libraries to register CT images acquired at planning and before treatment fractions. The deformation field determined was subsequently used to deform the delivered dose to match the anatomy of the planning CT. The large deformations involved required that the bladder and rectum volume be masked with uniform intensities of -1000 and 1000 HU, respectively, in both the planning and treatment CTs. The tool was tested for five prostate IGRT patients. The average rectum planning to treatment contour overlap improved from 67% to 93%, the lowest initial overlap is 43%. The average bladder overlap improved from 83% to 98%, with a lowest initial overlap of 60%. Registration regions were set to include a volume receiving 4% of the maximum dose. The average region was 320x210x63, taking approximately 9 min to register on a dual 2.8 GHz Linux system. The prostate and seminal vesicles were correctly placed even though they are not masked. The accumulated doses for multiple fractions with large deformation were computed and verified. The tool developed can effectively supply the previously delivered dose for adaptive planning to correct for interfractional changes.

  17. Fluorescent stereo microscopy for 3D surface profilometry and deformation mapping.

    PubMed

    Hu, Zhenxing; Luo, Huiyang; Du, Yingjie; Lu, Hongbing

    2013-05-20

    Recently, mechanobiology has received increased attention. For investigation of biofilm and cellular tissue, measurements of the surface topography and deformation in real-time are a pre-requisite for understanding the growth mechanisms. In this paper, a novel three-dimensional (3D) fluorescent microscopic method for surface profilometry and deformation measurements is developed. In this technique a pair of cameras are connected to a binocular fluorescent microscope to acquire micrographs from two different viewing angles of a sample surface doped or sprayed with fluorescent microparticles. Digital image correlation technique is used to search for matching points in the pairing fluorescence micrographs. After calibration of the system, the 3D surface topography is reconstructed from the pair of planar images. When the deformed surface topography is compared with undeformed topography using fluorescent microparticles for movement tracking of individual material points, the full field deformation of the surface is determined. The technique is demonstrated on topography measurement of a biofilm, and also on surface deformation measurement of the biofilm during growth. The use of 3D imaging of the fluorescent microparticles eliminates the formation of bright parts in an image caused by specular reflections. The technique is appropriate for non-contact, full-field and real-time 3D surface profilometry and deformation measurements of materials and structures at the microscale.

  18. The ANACONDA algorithm for deformable image registration in radiotherapy

    SciTech Connect

    Weistrand, Ola; Svensson, Stina

    2015-01-15

    Purpose: The purpose of this work was to describe a versatile algorithm for deformable image registration with applications in radiotherapy and to validate it on thoracic 4DCT data as well as CT/cone beam CT (CBCT) data. Methods: ANAtomically CONstrained Deformation Algorithm (ANACONDA) combines image information (i.e., intensities) with anatomical information as provided by contoured image sets. The registration problem is formulated as a nonlinear optimization problem and solved with an in-house developed solver, tailored to this problem. The objective function, which is minimized during optimization, is a linear combination of four nonlinear terms: 1. image similarity term; 2. grid regularization term, which aims at keeping the deformed image grid smooth and invertible; 3. a shape based regularization term which works to keep the deformation anatomically reasonable when regions of interest are present in the reference image; and 4. a penalty term which is added to the optimization problem when controlling structures are used, aimed at deforming the selected structure in the reference image to the corresponding structure in the target image. Results: To validate ANACONDA, the authors have used 16 publically available thoracic 4DCT data sets for which target registration errors from several algorithms have been reported in the literature. On average for the 16 data sets, the target registration error is 1.17 ± 0.87 mm, Dice similarity coefficient is 0.98 for the two lungs, and image similarity, measured by the correlation coefficient, is 0.95. The authors have also validated ANACONDA using two pelvic cases and one head and neck case with planning CT and daily acquired CBCT. Each image has been contoured by a physician (radiation oncologist) or experienced radiation therapist. The results are an improvement with respect to rigid registration. However, for the head and neck case, the sample set is too small to show statistical significance. Conclusions: ANACONDA

  19. Metatarsophalangeal Hyperextension Movement Pattern Related to Diabetic Forefoot Deformity

    PubMed Central

    Hastings, Mary K.; Mueller, Michael J.

    2016-01-01

    Background Metatarsophalangeal joint (MTPJ) hyperextension deformity is common in people with diabetic neuropathy and a known risk factor for ulceration and amputation. An MTPJ hyperextension movement pattern may contribute to the development of this acquired deformity. Objective The purpose of this study was to determine, in people with diabetes mellitus and peripheral neuropathy (DM+PN), the ankle and MTPJ ranges of motion that characterize an MTPJ hyperextension movement pattern and its relationship to MTPJ deformity severity. It was hypothesized that severity of MTPJ deformity would be related to limitations in maximum ankle dorsiflexion and increased MTPJ extension during active ankle dorsiflexion movement tasks. Design A cross-sectional study design was used that included 34 people with DM+PN (mean age=59 years, SD=9). Methods Computed tomography and 3-dimensional motion capture analysis were used to measure resting MTPJ angle and intersegmental foot motion during the tasks of ankle dorsiflexion and plantar flexion with the knee extended and flexed to 90 degrees, walking, and sit-to/from-stand. Results The MTPJ extension movement pattern during all tasks was directly correlated with severity of MTPJ deformity: maximum ankle dorsiflexion with knee extended (r=.35; 95% confidence interval [CI]=.02, .62), with knee flexed (r=.35; 95% CI=0.01, 0.61), during the swing phase of gait (r=.47; 95% CI=0.16, 0.70), during standing up (r=.48; 95% CI=0.17, 0.71), and during sitting down (r=.38; 95% CI=0.05, 0.64). All correlations were statistically significant. Limitations This study was cross-sectional, and causal relationships cannot be made. Conclusions A hyperextension MTPJ movement pattern associated with limited ankle dorsiflexion has been characterized in people with diabetic neuropathy. Increased MTPJ extension during movement and functional tasks was correlated with severity of resting MTPJ alignment. Repetition of this movement pattern could be an important

  20. Occurrence of oral deformities in larval anurans

    USGS Publications Warehouse

    Drake, D.L.; Altig, R.; Grace, J.B.; Walls, S.C.

    2007-01-01

    We quantified deformities in the marginal papillae, tooth rows, and jaw sheaths of tadpoles from 13 population samples representing three families and 11 sites in the southeastern United States. Oral deformities were observed in all samples and in 13.5-98% of the specimens per sample. Batrachochytrium dendrobatidis (chytrid) infections were detected in three samples. There was high variability among samples in the pattern and number of discovered deformities. Pairwise associations between oral structures containing deformities were nonrandom for several populations, especially those with B. dendrobatidis infections or high total numbers of deformities. Comparisons of deformities among samples using multivariate analyses revealed that tadpole samples grouped together by family. Analyses of ordination indicated that three variables, the number of deformities, the number of significant associations among deformity types within populations, and whether populations were infected with B. dendrobatidis, were significantly correlated with the pattern of deformities. Our data indicate that the incidence of oral deformities can be high in natural populations and that phylogeny and B. dendrobatidis infection exert a strong influence on the occurrence and type of oral deformities in tadpoles. ?? by the American Society of Ichthyologists and Herperologists.

  1. Mesh deformation based on artificial neural networks

    NASA Astrophysics Data System (ADS)

    Stadler, Domen; Kosel, Franc; Čelič, Damjan; Lipej, Andrej

    2011-09-01

    In the article a new mesh deformation algorithm based on artificial neural networks is introduced. This method is a point-to-point method, meaning that it does not use connectivity information for calculation of the mesh deformation. Two already known point-to-point methods, based on interpolation techniques, are also presented. In contrast to the two known interpolation methods, the new method does not require a summation over all boundary nodes for one displacement calculation. The consequence of this fact is a shorter computational time of mesh deformation, which is proven by different deformation tests. The quality of the deformed meshes with all three deformation methods was also compared. Finally, the generated and the deformed three-dimensional meshes were used in the computational fluid dynamics numerical analysis of a Francis water turbine. A comparison of the analysis results was made to prove the applicability of the new method in every day computation.

  2. Helium release during shale deformation: Experimental validation

    NASA Astrophysics Data System (ADS)

    Bauer, Stephen J.; Gardner, W. Payton; Heath, Jason E.

    2016-07-01

    This work describes initial experimental results of helium tracer release monitoring during deformation of shale. Naturally occurring radiogenic 4He is present in high concentration in most shales. During rock deformation, accumulated helium could be released as fractures are created and new transport pathways are created. We present the results of an experimental study in which confined reservoir shale samples, cored parallel and perpendicular to bedding, which were initially saturated with helium to simulate reservoir conditions, are subjected to triaxial compressive deformation. During the deformation experiment, differential stress, axial, and radial strains are systematically tracked. Release of helium is dynamically measured using a helium mass spectrometer leak detector. Helium released during deformation is observable at the laboratory scale and the release is tightly coupled to the shale deformation. These first measurements of dynamic helium release from rocks undergoing deformation show that helium provides information on the evolution of microstructure as a function of changes in stress and strain.

  3. Free radicals mediate systemic acquired resistance.

    PubMed

    Wang, Caixia; El-Shetehy, Mohamed; Shine, M B; Yu, Keshun; Navarre, Duroy; Wendehenne, David; Kachroo, Aardra; Kachroo, Pradeep

    2014-04-24

    Systemic acquired resistance (SAR) is a form of resistance that protects plants against a broad spectrum of secondary infections. However, exploiting SAR for the protection of agriculturally important plants warrants a thorough investigation of the mutual interrelationships among the various signals that mediate SAR. Here, we show that nitric oxide (NO) and reactive oxygen species (ROS) serve as inducers of SAR in a concentration-dependent manner. Thus, genetic mutations that either inhibit NO/ROS production or increase NO accumulation (e.g., a mutation in S-nitrosoglutathione reductase [GSNOR]) abrogate SAR. Different ROS function additively to generate the fatty-acid-derived azelaic acid (AzA), which in turn induces production of the SAR inducer glycerol-3-phosphate (G3P). Notably, this NO/ROS→AzA→G3P-induced signaling functions in parallel with salicylic acid-derived signaling. We propose that the parallel operation of NO/ROS and SA pathways facilitates coordinated regulation in order to ensure optimal induction of SAR.

  4. Acquiring synaesthesia: insights from training studies

    PubMed Central

    Rothen, Nicolas; Meier, Beat

    2014-01-01

    Synaesthesia denotes a condition of remarkable individual differences in experience characterized by specific additional experiences in response to normal sensory input. Synaesthesia seems to (i) run in families which suggests a genetic component, (ii) is associated with marked structural and functional neural differences, and (iii) is usually reported to exist from early childhood. Hence, synaesthesia is generally regarded as a congenital phenomenon. However, most synaesthetic experiences are triggered by cultural artifacts (e.g., letters, musical sounds). Evidence exists to suggest that synaesthetic experiences are triggered by the conceptual representation of their inducer stimuli. Cases were identified for which the specific synaesthetic associations are related to prior experiences and large scale studies show that grapheme-color associations in synaesthesia are not completely random. Hence, a learning component is inherently involved in the development of specific synaesthetic associations. Researchers have hypothesized that associative learning is the critical mechanism. Recently, it has become of scientific and public interest if synaesthetic experiences may be acquired by means of associative training procedures and whether the gains of these trainings are associated with similar cognitive benefits as genuine synaesthetic experiences. In order to shed light on these issues and inform synaesthesia researchers and the general interested public alike, we provide a comprehensive literature review on developmental aspects of synaesthesia and specific training procedures in non-synaesthetes. Under the light of a clear working definition of synaesthesia, we come to the conclusion that synaesthesia can potentially be learned by the appropriate training. PMID:24624072

  5. Transfusion-acquired AIDS in Taiwan.

    PubMed

    Yao, C; Wang, W W; Chung, Y M; Su, Y L; Liu, C Y; Chen, Y M

    1996-01-01

    Human immunodeficiency virus type 1 (HIV-1) can be transmitted through blood transfusion. The first transfusion-acquired immunodeficiency syndrome (AIDS) patient in Taiwan was a 46-year-old woman who received two units of whole blood during a hysterectomy at a provincial hospital in 1985. In 1991, she experienced a herpes zoster infection. In March 1993, she had extensive herpetic gingivostomatitis and another herpes zoster attack, and was treated at the same hospital. Two months later, she had oral candidiasis and was treated at a medical center. She was not tested for HIV-1 infection until she developed Pneumocystis carinii pneumonia in June 1993. In February 1994, and developed cytomegalovirus retinitis and died 6 months later. Donor blood given to the patients during the hysterectomy was HIV-1 positive. The donor's HIV infection was discovered in 1991 and he died of AIDS in 1993. As blood centers in Taiwan did not start screening for HIV-1 until January 1988, it is urgently recommended that any individual who received a blood transfusion between 1984 and 1987 in Taiwan and who currently experiences repeated episodes of opportunistic infections have an HIV-1 blood test. The receipt of a blood transfusion between 1984 and 1987 should be listed by the Department of Health as an indication for HIV-1 screening.

  6. [Thoracic manifestations of AIDS (acquired immunodeficiency syndrome)].

    PubMed

    Bernasconi, A; Zompatori, M; Chiodo, F; Costigliola, P; Ricchi, E; Colangeli, V; Canini, R; Gavelli, G

    1989-11-01

    AIDS (acquired immunodeficiency syndrome) seems to be related to human immunodeficiency virus (HIV) and is characterized by severe T-helpers lymphocyte dysfunction. Many of the AIDS patients (47-70%) develop pulmonary manifestations, both infectious and neoplastic, in the course of their disease. In the Department of Infectious Diseases of our Hospital are studied many patients HIV+. Every year 246 seropositive new patients have been discovered. Among them we have studied 25 subjects with respiratory disease, by chest radiographs; successively, according to clinical picture, we have performed thoracic computed tomography, Gallium scintigraphy, fiberoptic bronchoscopy with transbronchial biopsy (TBB), bronchoalveolar lavage (BAL); the majority of these patients (68%) had AIDS, only 28% had ARC and 4% had PGL. In our experience, the diagnosed diseases were mainly infections (92%), and most frequently (52%) due to Pneumocystis carinii, alone or in association with other etiologic agents. We have not found pathognomonic radiographic abnormalities, but chest X-ray evaluated with clinical and laboratory data, may often be useful to obtain diagnostic indications and in order to determine a more specific and aggressive diagnostic approach.

  7. Mycobacterial disease, immunosuppression, and acquired immunodeficiency syndrome.

    PubMed Central

    Collins, F M

    1989-01-01

    The mycobacteria are an important group of acid-fast pathogens ranging from obligate intracellular parasites such as Mycobacterium leprae to environmental species such as M. gordonae and M. fortuitum. The latter may behave as opportunistic human pathogens if the host defenses have been depleted in some manner. The number and severity of such infections have increased markedly with the emergence of the acquired immunodeficiency syndrome (AIDS) epidemic. These nontuberculous mycobacteria tend to be less virulent for humans than M. tuberculosis, usually giving rise to self-limiting infections involving the cervical and mesenteric lymph nodes of young children. However, the more virulent serovars of M. avium complex can colonize the bronchial and intestinal mucosal surfaces of healthy individuals, becoming virtual members of the commensal gut microflora and thus giving rise to low levels of skin hypersensitivity to tuberculins prepared from M. avium and M. intracellulare. Systemic disease develops when the normal T-cell-mediated defenses become depleted as a result of old age, cancer chemotherapy, or infection with human immunodeficiency virus. As many as 50% of human immunodeficiency virus antibody-positive individuals develop mycobacterial infections at some time during their disease. Most isolates of M. avium complex from AIDS patients fall into serotypes 4 and 8. The presence of these drug-resistant mycobacteria in the lungs of the AIDS patient makes their effective clinical treatment virtually impossible. More effective chemotherapeutic, prophylactic, and immunotherapeutic reagents are urgently needed to treat this rapidly increasing patient population. PMID:2680057

  8. Community-acquired pneumonia among smokers.

    PubMed

    Almirall, Jordi; Blanquer, José; Bello, Salvador

    2014-06-01

    Recent studies have left absolutely no doubt that tobacco increases susceptibility to bacterial lung infection, even in passive smokers. This relationship also shows a dose-response effect, since the risk reduces spectacularly 10 years after giving up smoking, returning to the level of non-smokers. Streptococcus pneumoniae is the causative microorganism responsible for community-acquired pneumonia (CAP) most frequently associated with smoking, particularly in invasive pneumococcal disease and septic shock. It is not clear how it acts on the progress of pneumonia, but there is evidence to suggest that the prognosis for pneumococcal pneumonia is worse. In CAP caused by Legionella pneumophila, it has also been observed that smoking is the most important risk factor, with the risk rising 121% for each pack of cigarettes smoked a day. Tobacco use may also favor diseases that are also known risk factors for CAP, such as periodontal disease and upper respiratory viral infections. By way of prevention, while giving up smoking should always be proposed, the use of the pneumococcal vaccine is also recommended, regardless of the presence of other comorbidities.

  9. Gastrointestinal Manifestations of the Acquired Immunodeficiency Syndrome

    PubMed Central

    Rodgers, Vance D.; Kagnoff, Martin F.

    1987-01-01

    In addition to abnormalities in systemic immune function, patients with the acquired immunodeficiency syndrome (AIDS) and the pre-AIDS syndromes have significant abnormalities in the distribution of T-cell subsets in the intestinal tract. Such immune deficits predispose such patients to opportunistic infections and tumors, many of which involve the gastrointestinal tract. For example, Candida albicans often causes stomatitis and esophagitis. Intestinal infections with parasites (Cryptosporidium, Isospora belli, Microsporidia) or bacteria (Mycobacterium avium-intracellulare) are associated with severe diarrhea and malabsorption, whereas viruses like cytomegalovirus and herpes simplex virus cause mucosal ulcerations. Clinically debilitating chronic diarrhea develops in many AIDS patients for which no clear cause can be identified. Enteric pathogens like Salmonella and Campylobacter can be associated with bacteremias. Kaposi's sarcoma and lymphoma involving the intestinal tract are now well-recognized complications of AIDS. Although AIDS is not associated with a pathognomonic liver lesion, opportunistic infections and Kaposi's sarcoma or lymphoma may involve the liver. ImagesFigure 3.Figure 4.Figure 5.Figure 6.Figure 7. PMID:3825111

  10. Biomarkers in Pediatric Community-Acquired Pneumonia

    PubMed Central

    Principi, Nicola; Esposito, Susanna

    2017-01-01

    Community-acquired pneumonia (CAP) is an infectious disease caused by bacteria, viruses, or a combination of these infectious agents. The severity of the clinical manifestations of CAP varies significantly. Consequently, both the differentiation of viral from bacterial CAP cases and the accurate assessment and prediction of disease severity are critical for effectively managing individuals with CAP. To solve questionable cases, several biomarkers indicating the etiology and severity of CAP have been studied. Unfortunately, only a few studies have examined the roles of these biomarkers in pediatric practice. The main aim of this paper is to detail current knowledge regarding the use of biomarkers to diagnose and treat CAP in children, analyzing the most recently published relevant studies. Despite several attempts, the etiologic diagnosis of pediatric CAP and the estimation of the potential outcome remain unsolved problems in most cases. Among traditional biomarkers, procalcitonin (PCT) appears to be the most effective for both selecting bacterial cases and evaluating the severity. However, a precise cut-off separating bacterial from viral and mild from severe cases has not been defined. The three-host protein assay based on C-reactive protein (CRP), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), plasma interferon-γ protein-10 (IP-10), and micro-array-based whole genome expression arrays might offer more advantages in comparison with former biomarkers. However, further studies are needed before the routine use of those presently in development can be recommended. PMID:28218726

  11. Identification of acquired DNA in Neisseria lactamica.

    PubMed

    van Passel, Mark W J; Bart, Aldert; Luyf, Angela C M; van Kampen, Antoine H C; van der Ende, Arie

    2006-09-01

    Anomalous DNA (aDNA) in prokaryotic genomes, identified by its aberrant nucleotide composition, generally represents horizontally acquired DNA. Previous studies showed that frequent DNA transfer occurs between commensal Neisseriae and Neisseria meningitidis. Currently, it is unknown whether aDNA regions are also transferred between these species. The genome of Neisseria lactamica strain 892586 was assessed by a strategy that enables the selective isolation of aDNA, using endonucleases with recognition sites that are overrepresented in aDNA. Of eight regions with aDNA, five displayed similarity to virulence-associated meningococcal sequences. Of three aDNA fragments with limited or no similarity to neisserial sequences, one encodes a novel putative autotransporter/adhesin. The remaining two fragments are adjacent in the N. lactamica genome, and encode a novel putative ATPase/subtilisin-like protease operon. A similar operon is present in the genomes of different respiratory tract pathogens. The identification of aDNA from N. lactamica with similarity to meningococcal aDNA shows that genetic exchange between the Neisseriae is not limited to the neisserial core genome. The discovery of aDNA in N. lactamica similar to a locus in other pathogens substantially expands the neisserial gene pool.

  12. Natural and acquired macrolide resistance in mycobacteria.

    PubMed

    Doucet-Populaire, F; Buriánková, K; Weiser, J; Pernodet, J-L

    2002-12-01

    The genus Mycobacterium contains two of the most important human pathogens, Mycobacterium tuberculosis and Mycobacterium leprae, the etiologic agents of tuberculosis and leprosy, respectively. Other mycobacteria are mostly saprophytic organisms, living in soil and water, but some of them can cause opportunistic infections. The increasing incidence of tuberculosis as well as infections with non-tuberculous mycobacteria (NTM) in AIDS patients has renewed interest in molecular mechanisms of drug resistance in these pathogens. Mycobacteria show a high degree of intrinsic resistance to most common antibiotics. For instance, species from the M. tuberculosis complex (MTC) are intrinsically resistant to macrolides. Nevertheless, some semi-synthetic macrolides as the erythromycin derivatives clarithromycin, azithromycin and most recently the ketolides, are active against NTM, particularly Mycobacterium avium, and some of them are widely used for infection treatment. However, shortly after the introduction of these new drugs, resistant strains appeared due to mutations in the macrolide target, the ribosome. The mycobacterial cell wall with its specific composition and structure is considered to be a major factor in promoting the natural resistance of mycobacteria to various antibiotics. However, to explain the difference in macrolide sensitivity between the MTC and NTM, the synergistic contribution of a specific resistance mechanism might be required, in addition to possible differences in cell wall permeability. This mini-review summarizes the current knowledge on the natural and acquired macrolide resistance in mycobacteria, gives an overview of potential mechanisms implicated in the intrinsic resistance and brings recent data concerning a macrolide resistance determinant in the MTC.

  13. [Acquired and congenital heart diseases during pregancy].

    PubMed

    De Feo, Stefania; Iacovoni, Attilio; Faggiano, Pompilio

    2012-05-01

    Heart diseases are the leading cause of maternal morbidity and mortality. The number of patients with congenital heart diseases reaching childbearing age, as well as the proportion of women with acquired conditions, such as ischemic heart disease, becoming pregnant is constantly increasing. All women with known heart disease should have pre-pregnancy counseling, to assess maternal and fetal risk. Women at moderate or high risk should be under the care of a specialist prenatal team with experience in managing women with heart disease during pregnancy. Conditions that are considered at particularly high risk (mortality >10%) include Marfan syndrome with dilated aortic root, severe left ventricular dysfunction, severe left heart obstructive lesions, and pulmonary hypertension. Peripartum cardiomyopathy is a rare and potentially fatal disease related to pregnancy and the postnatal period that presents with symptoms of congestion and/or hypoperfusion and may rapidly progress to acute and life-threatening heart failure. However, the majority of women with heart disease can tolerate pregnancy; therefore an adequate multidisciplinary approach with the gynecologist, anesthesiologist and cardiologist should be advocated in order to reduce maternal and fetal risks associated with pregnancy.

  14. The complex pathophysiology of acquired aplastic anaemia.

    PubMed

    Zeng, Y; Katsanis, E

    2015-06-01

    Immune-mediated destruction of haematopoietic stem/progenitor cells (HSPCs) plays a central role in the pathophysiology of acquired aplastic anaemia (aAA). Dysregulated CD8(+) cytotoxic T cells, CD4(+) T cells including T helper type 1 (Th1), Th2, regulatory T cells and Th17 cells, natural killer (NK) cells and NK T cells, along with the abnormal production of cytokines including interferon (IFN)-γ, tumour necrosis factor (TNF)-α and transforming growth factor (TGF)-β, induce apoptosis of HSPCs, constituting a consistent and defining feature of severe aAA. Alterations in the polymorphisms of TGF-β, IFN-γ and TNF-α genes, as well as certain human leucocyte antigen (HLA) alleles, may account for the propensity to immune-mediated killing of HSPCs and/or ineffective haematopoiesis. Although the inciting autoantigens remain elusive, autoantibodies are often detected in the serum. In addition, recent studies provide genetic and molecular evidence that intrinsic and/or secondary deficits in HSPCs and bone marrow mesenchymal stem cells may underlie the development of bone marrow failure.

  15. Male body image following acquired brain injury.

    PubMed

    Howes, Hannah; Edwards, Stephen; Benton, David

    2005-02-01

    The purpose of this study was to investigate body image concerns and psycho-emotional health in males with acquired brain injury (ABI). Using a between subjects study of 25 males with ABI and 25 matched controls, variables were analysed using correlations and 2 x 2 analyses of variance (ANOVAs) with head injury and injury type as independent variables. Body image and psycho-emotional health were evaluated using self-report questionnaires. Disability and cognitive impairment were measured using a mixture of self-report, cognitive testing and clinical notes. Results indicated that males with ABI had significantly lower self-esteem and body dissatisfaction on a number of items relating to physical and sexual functioning. There were significant differences in body image between stroke and TBI, but there was no corresponding relationship with psycho-emotional health. These body image differences might be explained by age. The finding that ABI has a negative effect on body image and that this relates to psycho-emotional health should be investigated further, perhaps being included in future rehabilitation strategies.

  16. The inheritance of acquired epigenetic variations.

    PubMed

    Jablonka, Eva; Lamb, Marion J

    2015-08-01

    There is evidence that the functional history of a gene in one generation can influence its expression in the next. In somatic cells, changes in gene activity are frequently associated with changes in the pattern of methylation of the cytosines in DNA; these methylation patterns are stably inherited. Recent work suggests that information about patterns of methylation and other epigenetic states can also be transmitted from parents to offspring. This evidence is the basis of a model for the inheritance of acquired epigenetic variations. According to the model, an environmental stimulus can induce heritable chromatin modifications which are very specific and predictable, and might result in an adaptive response to the stimulus. This type of response probably has most significance for adaptive evolution in organisms such as fungi and plants, which lack distinct segregation of the soma and germ line. However, in all organisms, the accumulation of specific and random chromatin modifications in the germ line may be important in speciation, because these modifications could lead to reproductive isolation between populations. Heritable chromatin variations may also alter the frequency and distribution of classical mutations and meiotic recombination. Therefore, inherited epigenetic changes in the structure of chromatin can influence neo-Darwinian evolution as well as cause a type of "Lamarckian" inheritance.

  17. In vivo models of cortical acquired epilepsy

    PubMed Central

    Chauvette, Sylvain; Soltani, Sara; Seigneur, Josée; Timofeev, Igor

    2015-01-01

    The neocortex is the site of origin of several forms of acquired epilepsy. Here we provide a brief review of experimental models that were recently developed to study neocortical epileptogenesis as well as some major results obtained with these methods. Most of neocortical seizures appear to be nocturnal and it is known that neuronal activities reveal high levels of synchrony during slow-wave sleep. Therefore, we start the review with a description of mechanisms of neuronal synchronization and major forms of synchronized normal and pathological activities. Then, we describe three experimental models of seizures and epileptogenesis: ketamine-xylazine anesthesia as feline seizure triggered factor, cortical undercut as cortical penetrating wound model and neocortical kindling. Besides specific technical details describing these models we also provide major features of pathological brain activities recorded during epileptogenesis and seizures. The most common feature of all models of neocortical epileptogenesis is the increased duration of network silent states that up-regulates neuronal excitability and eventually leads to epilepsy. PMID:26343530

  18. Acquired immunodeficiency syndrome in older African Americans.

    PubMed

    Funnyé, Allen S; Akhtar, Abbasi J; Biamby, Gisele

    2002-04-01

    The purpose of this study was to determine if older African Americans are disproportionately affected by acquired immunodeficiency syndrome (AIDS), and to review the clinical impact of AIDS and the importance of prevention and treatment efforts. A review of the literature and statistics was obtained using Medline and the AIDS Public Information Data Set offered by the Centers for Disease Control and Prevention. Twenty-seven percent of the U.S. population is above the age of 50, and the number of AIDS cases in this group is growing, with African Americans accounting for the highest proportion of cases and deaths. Testing for HIV may be delayed and symptoms attributed to other illnesses. Though 5% of new cases occur in those over 50, prevention programs, testing, and the perception of risk by providers may be insufficient. There are few research studies on HIV treatment in older patients and no specific guidelines for antiretroviral treatments available. Although death rates for AIDS has been declining, adults over 50 still have the highest mortality rate. Co-morbid conditions, such as heart disease and hypertension, may require taking multiple drugs, which may complicate treatment. Increasing heterosexual transmission rates and a lack of information on HIV reinforces the need for specific prevention programs targeted toward older African Americans.

  19. In vivo models of cortical acquired epilepsy.

    PubMed

    Chauvette, Sylvain; Soltani, Sara; Seigneur, Josée; Timofeev, Igor

    2016-02-15

    The neocortex is the site of origin of several forms of acquired epilepsy. Here we provide a brief review of experimental models that were recently developed to study neocortical epileptogenesis as well as some major results obtained with these methods. Most of neocortical seizures appear to be nocturnal and it is known that neuronal activities reveal high levels of synchrony during slow-wave sleep. Therefore, we start the review with a description of mechanisms of neuronal synchronization and major forms of synchronized normal and pathological activities. Then, we describe three experimental models of seizures and epileptogenesis: ketamine-xylazine anesthesia as feline seizure triggered factor, cortical undercut as cortical penetrating wound model and neocortical kindling. Besides specific technical details describing these models we also provide major features of pathological brain activities recorded during epileptogenesis and seizures. The most common feature of all models of neocortical epileptogenesis is the increased duration of network silent states that up-regulates neuronal excitability and eventually leads to epilepsy.

  20. Acquired prosopagnosia: structural basis and processing impairments.

    PubMed

    Davies-Thompson, Jodie; Pancaroglu, Raika; Barton, Jason

    2014-01-01

    Cognitive models propose a hierarchy of parallel processing stages in face perception, and functional neuroimaging shows a network of regions involved in face processing. Reflecting this, acquired prosopagnosia is not a single entity but a family of disorders with different anatomic lesions and different functional deficits. One classic distinction is between an apperceptive variant, in which there is impaired perception of facial structure, and an associative/amnestic variant, in which perception is relatively intact, with subsequent problems matching perception to facial memories, because of either disconnection or loss of those memories. These disorders also have to be distinguished from people-specific amnesia, a multimodal impairment, and prosop-anomia, in which familiarity with faces is preserved but access to names is disrupted. These different disorders can be conceived as specific deficits at different processing stages in cognitive models, and suggests that these functional stages may have distinct neuroanatomic substrates. It remains to be seen whether a similar anatomic and functional variability is present in developmental prosopagnosia.

  1. Deformable medical image registration of pleural cavity for photodynamic therapy by using finite-element based method

    NASA Astrophysics Data System (ADS)

    Penjweini, Rozhin; Kim, Michele M.; Dimofte, Andrea; Finlay, Jarod C.; Zhu, Timothy C.

    2016-03-01

    When the pleural cavity is opened during the surgery portion of pleural photodynamic therapy (PDT) of malignant mesothelioma, the pleural volume will deform. This impacts the delivered dose when using highly conformal treatment techniques. To track the anatomical changes and contour the lung and chest cavity, an infrared camera-based navigation system (NDI) is used during PDT. In the same patient, a series of computed tomography (CT) scans of the lungs are also acquired before the surgery. The reconstructed three-dimensional contours from both NDI and CTs are imported into COMSOL Multiphysics software, where a finite element-based (FEM) deformable image registration is obtained. The CT contour is registered to the corresponding NDI contour by overlapping the center of masses and aligning their orientations. The NDI contour is considered as the reference contour, and the CT contour is used as the target one, which will be deformed. Deformed Geometry model is applied in COMSOL to obtain a deformed target contour. The distortion of the volume at X, Y and Z is mapped to illustrate the transformation of the target contour. The initial assessment shows that FEM-based image deformable registration can fuse images acquired by different modalities. It provides insights into the deformation of anatomical structures along X, Y and Z-axes. The deformed contour has good matches to the reference contour after the dynamic matching process. The resulting three-dimensional deformation map can be used to obtain the locations of other critical anatomic structures, e.g., heart, during surgery.

  2. Deformable medical image registration of pleural cavity for photodynamic therapy by using finite-element based method

    PubMed Central

    Penjweini, Rozhin; Kim, Michele M.; Dimofte, Andrea; Finlay, Jarod C; Zhu, Timothy C.

    2016-01-01

    When the pleural cavity is opened during the surgery portion of pleural photodynamic therapy (PDT) of malignant mesothelioma, the pleural volume will deform. This impacts the delivered dose when using highly conformal treatment techniques. To track the anatomical changes and contour the lung and chest cavity, an infrared camera–based navigation system (NDI) is used during PDT. In the same patient, a series of computed tomography (CT) scans of the lungs are also acquired before the surgery. The reconstructed three-dimensional contours from both NDI and CTs are imported into COMSOL Multiphysics software, where a finite element-based (FEM) deformable image registration is obtained. The CT contour is registered to the corresponding NDI contour by overlapping the center of masses and aligning their orientations. The NDI contour is considered as the reference contour, and the CT contour is used as the target one, which will be deformed. Deformed Geometry model is applied in COMSOL to obtain a deformed target contour. The distortion of the volume at X, Y and Z is mapped to illustrate the transformation of the target contour. The initial assessment shows that FEM-based image deformable registration can fuse images acquired by different modalities. It provides insights into the deformation of anatomical structures along X, Y and Z-axes. The deformed contour has good matches to the reference contour after the dynamic matching process. The resulting three-dimensional deformation map can be used to obtain the locations of other critical anatomic structures, e.g., heart, during surgery. PMID:27053826

  3. Deformable medical image registration of pleural cavity for photodynamic therapy by using finite-element based method.

    PubMed

    Penjweini, Rozhin; Kim, Michele M; Dimofte, Andrea; Finlay, Jarod C; Zhu, Timothy C

    2016-03-07

    When the pleural cavity is opened during the surgery portion of pleural photodynamic therapy (PDT) of malignant mesothelioma, the pleural volume will deform. This impacts the delivered dose when using highly conformal treatment techniques. To track the anatomical changes and contour the lung and chest cavity, an infrared camera-based navigation system (NDI) is used during PDT. In the same patient, a series of computed tomography (CT) scans of the lungs are also acquired before the surgery. The reconstructed three-dimensional contours from both NDI and CTs are imported into COMSOL Multiphysics software, where a finite element-based (FEM) deformable image registration is obtained. The CT contour is registered to the corresponding NDI contour by overlapping the center of masses and aligning their orientations. The NDI contour is considered as the reference contour, and the CT contour is used as the target one, which will be deformed. Deformed Geometry model is applied in COMSOL to obtain a deformed target contour. The distortion of the volume at X, Y and Z is mapped to illustrate the transformation of the target contour. The initial assessment shows that FEM-based image deformable registration can fuse images acquired by different modalities. It provides insights into the deformation of anatomical structures along X, Y and Z-axes. The deformed contour has good matches to the reference contour after the dynamic matching process. The resulting three-dimensional deformation map can be used to obtain the locations of other critical anatomic structures, e.g., heart, during surgery.

  4. Long-range ground deformation monitoring by InSAR analysis

    NASA Astrophysics Data System (ADS)

    Rokugawa, S.; Nakamura, T.

    2015-11-01

    InSAR (Interferometric Synthetic Aperture Radar) analysis is an effective technique to map 3-dimensional surface deformation with high spatial resolution. The aim of this study was to evaluate the capability of InSAR analysis when applied to ground monitoring of an environmental disaster. We performed a time series InSAR analysis using ENVISAT/ASAR and ALOS/PALSAR data and commercial software to investigate subsidence around the Kanto District of Japan. We also investigated techniques for efficient early detection of landslides in Kyushu using time series analysis that incorporated synthetic aperture radar (SAR) images. ENVISAT/ASAR data acquired from 2003-2010 and ALOS/PALSAR data acquired from 2006-2011 were used to detect poorly expressed geomorphological deformation by conducting time series analyses of periodically acquired SAR data. In addition, to remove noise caused by geographical feature stripes or phase retardation, we applied median filtering, histogram extraction processing, and clarification of the displacement with a Laplacian filter. The main functions of the InSAR time series analysis are the calculation of phase differences between two images and the inversion with smoothness constraint for the estimation of deformation along the line of sight. The results enabled us to establish criteria for the selection of suitable InSAR data pairs, and provided the final error estimation of the derived surface deformation. The results of the analysis in the Kanto District suggested that localized areas of uplift and subsidence have occurred at irregular intervals in this area. Furthermore, the method offers the possibility of early warning of environmental disasters such as landslide and abrupt subsidence. Our results confirm the effectiveness of InSAR analysis for the monitoring of ground deformation over wide areas via the detection of localized subsidence and landslides.

  5. Habit tic nail deformity - a rare presentation in an 8 year old boy.

    PubMed

    El-Heis, S; Abadie, Al

    2016-11-15

    Habit tic nail deformity is a nail dystrophy resulting from habitual, repetitive trauma to the nail. It is usually acquired in adulthood, however, we report a case of habit tic nail deformity in an 8 year old boy. The diagnosis was made clinically with further history revealing that the boy repeatedly rubbed his thumbnails and pushed the cuticles. Emollient cream (Balneum®) was recommended twice daily and both the patient and his mother were educated on the behavioral nature of this condition. There was marked improvement at 6 months of treatment and further improvement at 12 months.We note that habit tic nail deformity is not exclusive to adults. Diagnosis can be made clinically. History and physical examination provide valuable clues and psychosocial links must be explored and addressed. Management is challenging and compliance with treatment is variable. Patient education, barrier methods, and behavioral therapy can be helpful in preventing further trauma to the nails.

  6. SBAS-InSAR analysis of surface deformation at Mauna Loa and Kilauea volcanoes in Hawaii

    USGS Publications Warehouse

    Casu, F.; Lanari, Riccardo; Sansosti, E.; Solaro, G.; Tizzani, Pietro; Poland, M.; Miklius, Asta

    2009-01-01

    We investigate the deformation of Mauna Loa and K??lauea volcanoes, Hawai'i, by exploiting the advanced differential Synthetic Aperture Radar Interferometry (InSAR) technique referred to as the Small BAseline Subset (SBAS) algorithm. In particular, we present time series of line-of-sight (LOS) displacements derived from SAR data acquired by the ASAR instrument, on board the ENVISAT satellite, from the ascending (track 93) and descending (track 429) orbits between 2003 and 2008. For each coherent pixel of the radar images we compute time-dependent surface displacements as well as the average LOS deformation rate. Our results quantify, in space and time, the complex deformation of Mauna Loa and K??lauea volcanoes. The derived InSAR measurements are compared to continuous GPS data to asses the quality of the SBAS-InSAR products. ??2009 IEEE.

  7. Three-Dimensional Dynamic Deformation Measurements Using Stereoscopic Imaging and Digital Speckle Photography

    SciTech Connect

    Prentice, H. J.; Proud, W. G.

    2006-07-28

    A technique has been developed to determine experimentally the three-dimensional displacement field on the rear surface of a dynamically deforming plate. The technique combines speckle analysis with stereoscopy, using a modified angular-lens method: this incorporates split-frame photography and a simple method by which the effective lens separation can be adjusted and calibrated in situ. Whilst several analytical models exist to predict deformation in extended or semi-infinite targets, the non-trivial nature of the wave interactions complicates the generation and development of analytical models for targets of finite depth. By interrogating specimens experimentally to acquire three-dimensional strain data points, both analytical and numerical model predictions can be verified more rigorously. The technique is applied to the quasi-static deformation of a rubber sheet and dynamically to Mild Steel sheets of various thicknesses.

  8. A Vision-Based Methodology to Dynamically Track and Describe Cell Deformation during Cell Micromanipulation

    NASA Astrophysics Data System (ADS)

    Karimirad, Fatemeh; Shirinzadeh, Bijan; Yan, Wenyi; Fatikow, Sergej

    2013-02-01

    The main objective of this article is to mechanize the procedure of tracking and describing the various phases of deformation of a biological circular cell during micromanipulation. The devised vision-based methodology provides a real-time strategy to track and describe the cell deformation by extracting a geometric feature called dimple angle. An algorithm based on Snake was established to acquire the boundary of the indenting cell and measure the aforementioned feature. Micromanipulation experiments were conducted for zebrafish embryos. Experimental results were used to characterize the deformation of the manipulating embryo by the devised geometric parameter. The results demonstrated the high capability of the methodology. The proposed method is applicable to the micromanipulation of other circular biological embryos such as injection of the mouse oocyte/embryo. Supplemental materials are available for this article. Go to the publisher's online edition of the International Journal of Optomechatronics to view the supplemental files.

  9. Visualization of cardiac dynamics using physics-based deformable model

    NASA Astrophysics Data System (ADS)

    Lin, Wei-te; Robb, Richard A.

    2000-04-01

    Modeling of moving anatomic structures is complicated by the complexity of motion intrinsic and extrinsic to the structures. However when motion is cyclical, such as in heart, effective dynamic modeling can be approached using modern fast imaging techniques, which provide 3D structural data. Data may be acquired as a sequence of 3D volume images throughout the cardiac cycle. To model the intricate non- linear motion of the heart, we created a physics-based surface model which can realistically deform between successive time points in the cardiac cycle, yielding a dynamic 4D model of cardiac motion. Sequences of fifteen 3D volume images of intact canine beating hearts were acquired during compete cardiac cycles using the Dynamic Spatial Reconstructor and the Electron Beam CT. The chambers of the heart were segmented at successive time points, typically at 1/15-second intervals. The left ventricle of the first item point was reconstructed as an initial triangular mesh. A mass-spring physics-based deformable model, which can expand and shrink with local contraction and stretching forces distributed in an anatomically accurate simulation of cardiac motion, was applied to the initial mesh and allowed the initial mesh to deform to fit the left ventricle in successive time increments of the sequence. The resultant 4D model can be interactively transformed and displayed with associated regional electrical activity mapped onto the anatomic surfaces, producing a 5D mode, which faithfully exhibits regional cardiac contraction and relaxation patterns over the entire heart. For acquisition systems that may provide only limited 4D data, the model can provide interpolated anatomic shape between time points. This physics-based deformable model accurately represents dynamic cardiac structural changes throughout the cardiac cycle. Such models provides the framework for minimizing the number of time points required to usefully depict regional motion of myocardium and allowing

  10. Deformation and recrystallization mechanisms in naturally deformed sillimanites

    NASA Astrophysics Data System (ADS)

    Lambregts, P. J.; van Roermund, H. L. M.

    1990-07-01

    Prismatic sillimanite (Al 2SiO 5), with a length between 0.3 and 2.5 mm, was obtained from a garnet migmatite. The sillimanite, naturally deformed at a temperature of 750 ° C and a confining pressure of 6 kbar, has been studied using optical and transmission electron microscopy techniques. Optical and universal stage measurements reveal undulatory extinction, "sharp" deformation-induced subgrain boundaries (subparallel to (001) and (010)) and minor recrystallization. Transmission electron microscopy shows free dislocations, dislocation loops, (110) planar defects and tiltwalls parallel to (001). Dislocations have Burgers vectors of [001] and [100]. All isolated dislocations are dissociated. The dominant slip system is (100) [001] with subordinate (001) [100]. The microstructure of sillimanite indicates that recrystallization has occurred by a rotation mechanism (around [010]), where single crystals become polycrystals by the progressive development of numerous internal high-angle boundaries. The latter have been interpreted as originating from low-angle (001) tilt- and (010) twistwalls. Rotation recrystallization was followed by grain boundary migration.

  11. Leukocyte deformability: finite element modeling of large viscoelastic deformation.

    PubMed

    Dong, C; Skalak, R

    1992-09-21

    An axisymmetric deformation of a viscoelastic sphere bounded by a prestressed elastic thin shell in response to external pressure is studied by a finite element method. The research is motivated by the need for understanding the passive behavior of human leukocytes (white blood cells) and interpreting extensive experimental data in terms of the mechanical properties. The cell at rest is modeled as a sphere consisting of a cortical prestressed shell with incompressible Maxwell fluid interior. A large-strain deformation theory is developed based on the proposed model. General non-linear, large strain constitutive relations for the cortical shell are derived by neglecting the bending stiffness. A representation of the constitutive equations in the form of an integral of strain history for the incompressible Maxwell interior is used in the formulation of numerical scheme. A finite element program is developed, in which a sliding boundary condition is imposed on all contact surfaces. The mathematical model developed is applied to evaluate experimental data of pipette tests and observations of blood flow.

  12. Community-Acquired Legionella pneumophila Pneumonia

    PubMed Central

    Viasus, Diego; Di Yacovo, Silvana; Garcia-Vidal, Carolina; Verdaguer, Ricard; Manresa, Frederic; Dorca, Jordi; Gudiol, Francesc; Carratalà, Jordi

    2013-01-01

    Abstract Legionella pneumophila has been increasingly recognized as a cause of community-acquired pneumonia (CAP) and an important public health problem worldwide. We conducted the present study to assess trends in epidemiology, diagnosis, clinical features, treatment, and outcomes of sporadic community-acquired L. pneumophila pneumonia requiring hospitalization at a university hospital over a 15-year period (1995–2010). Among 3934 nonimmunosuppressed hospitalized patients with CAP, 214 (5.4%) had L. pneumophila pneumonia (16 cases were categorized as travel-associated pneumonia, and 21 were part of small clusters). Since the introduction of the urinary antigen test, the diagnosis of L. pneumophila using this method remained stable over the years (p = 0.42); however, diagnosis by means of seroconversion and culture decreased (p < 0.001 and p = 0.001, respectively). The median age of patients with L. pneumophila pneumonia was 58.2 years (SD 13.8), and 76.4% were male. At least 1 comorbid condition was present in 119 (55.6%) patients with L. pneumophila pneumonia, mainly chronic heart disease, diabetes mellitus, and chronic pulmonary disease. The frequency of older patients (aged >65 yr) and comorbidities among patients with L. pneumophila pneumonia increased over the years (p = 0.06 and p = 0.02, respectively). In addition, 100 (46.9%) patients were classified into high-risk classes according to the Pneumonia Severity Index (groups IV–V). Twenty-four (11.2%) patients with L. pneumophila pneumonia received inappropriate empirical antibiotic therapy at hospital admission. Compared with patients who received appropriate empirical antibiotic, patients who received inappropriate therapy more frequently had acute onset of illness (p = 0.004), pleuritic chest pain (p = 0.03), and pleural effusion (p = 0.05). The number of patients who received macrolides decreased over the study period (p < 0.001), whereas the number of patients who received levofloxacin increased (p

  13. [Acquired pendular nystagmus after pontine hemorrhage].

    PubMed

    Yokota, J; Kosaka, K; Yoshimoto, Y; Amakusa, T

    1999-12-01

    A 60-year-old hypertensive woman had a pontine hemorrhage that caused slight right hemiplegia, deep sensory disturbance on her right side and dysarthria. Three months after the stroke, she was transferred to our hospital for rehabilitation. Approximately 6 months later, she gradually began to complain of the visual oscillation. Continual, unceasing conjugate vertical/rotatory eye movements were observed. Fixation was momentary at best because of an inability to dampen the spontaneous eye movements. Electrooculography (EOG) showed bilateral vertical/rotatory sinusoidal eye movements of 2.5 Hz frequency and 10- to 35-degree amplitude. Both vertical and horizontal optokinetic nystagmus were absent. Caloric stimulation did not evoke any responses bilaterally. There were no rhythmical movements at similar frequencies in other parts of the body such as palatal myoclonus. MRI revealed not only hematoma mainly at the dorsal pontine tegmentum but also hypertrophy of the inferior olive nucleus, suggesting disruption of the central tegmental tract. Lesions of this tract may be one cause of pendular nystagmus. Several drug therapies were investigated for the nystagmus. There was no response to baclofen 15 mg. Trihexyphenidyl 4 mg was discontinued because of drug-induced hallucinations. Tiapride 600 mg and phenobarbital 90 mg were each slightly effective in reducing both frequency and amplitude of nystagmus. Treatment with clonazepam 1 mg resulted in the striking disappearance of nystagmus. She was aware of this and no longer experienced oscillopsia. Despite the visual benefit, however, the patient did not wish to continue this drug because of drowsiness and muscle relaxation. The potential long-term therapeutic application of clonazepam should be further investigated. To our knowledge, there have been no reports of successful treatment in acquired pendular nystagmus with clonazepam. Therefore, based on this favorable experience, it is suggested that clonazepam should be added

  14. Nursing home-acquired pneumonia. Treatment options.

    PubMed

    Marrie, T J; Slayter, K L

    1996-05-01

    Nursing home-acquired pneumonia (NHAP) is a diagnostic and therapeutic challenge, and antimicrobial therapy represents only 1 facet of the treatment of this disease. The nursing home population consists of a mixture of well, frail and dependent elderly. For some residents, supportive care may be the best therapeutic option. A variety of antimicrobial regimens have been proposed for the empirical therapy of NHAP; however, there are still very few data from controlled clinical trials that assess outcome. The clinical trials that have been completed support the concept that an early switch from intravenous to oral therapy can be successfully used to treat pneumonia affecting frail, often seriously ill, groups of patients. Annual influenza vaccine should be offered to all nursing home residents. This practice is about 50% effective in preventing hospitalisation and pneumonia, and about 80% effective in preventing death. The same level of evidence is not available to support the use of pneumococcal vaccine in this group; however, current practice suggests that all nursing home residents receive this vaccine on admission and once every 6 years thereafter. Frequently, knowledge about pneumonia is not applied as optimally as should be done. Care maps have been shown to reduce length of stay and shorten the time from emergency room entry until administration of antibiotic therapy by up to 3 hours. Areas for urgent research attention in patients with NHAP are: (a) proper studies to define the microbiological aetiology of NHAP (this requires bronchoscopy with sampling of the distal airways using a protected bronchial brush); (b) randomised controlled clinical trials of sufficient size to determine whether one antibiotic regimen is superior to another (currently most trials are designed to show that the agent under study is equivalent to a currently used agent); and (c) end-of-life decision making in the nursing home population.

  15. Chapter 22: Hereditary and acquired angioedema.

    PubMed

    Georgy, Mary S; Pongracic, Jacqueline A

    2012-01-01

    Hereditary angioedema (HAE) is an autosomal dominant disorder defined by a deficiency of functional C1 esterase inhibitor (C1-INH). Acquired angioedema (AAE) is caused by either consumption (type 1) or inactivation (type 2) of CI-INH. Both HAE and AAE can be life-threatening. The screening test for both conditions is complement component C4, which is low to absent at times of angioedema or during quiescent periods. A useful test to differentiate HAE from AAE is C1q protein, which is normal in HAE and low in AAE. There are three types of HAE: type 1 HAE is most common, occurring in ∼85% of patients and characterized by decreased production of C1-INH, resulting in reduced functional activity to 5-30% of normal. In type 2, which occurs in 15% of cases, C1-INH is detectable in normal or elevated quantities but is dysfunctional. Finally, type 3, which is rare and almost exclusively occurs in women, is estrogen dependent and associated with normal CI-INH and C4 levels. One-third of these patients have a gain-of-function mutation in clotting factor XII leading to kallikrein-driven bradykinin production. Although the anabolic steroid, danazol, is useful in increasing the concentration of C4 and reducing the episodes of angioedema in HAE and AAE, it has expected adverse effects. Fortunately, disease-specific therapies are available and include C1-INH enzyme for i.v. infusion either acutely or empirically, ecallantide, an inhibitor of kallikrein, and icatibant, a bradykinin B2-receptor antagonist, both approved for acute angioedema and administered, subcutaneously.

  16. Impact of lactobacilli on orally acquired listeriosis

    PubMed Central

    Archambaud, Cristel; Nahori, Marie-Anne; Soubigou, Guillaume; Bécavin, Christophe; Laval, Laure; Lechat, Pierre; Smokvina, Tamara; Langella, Philippe; Lecuit, Marc; Cossart, Pascale

    2012-01-01

    Listeria monocytogenes is a foodborne pathogen that crosses the intestinal barrier and disseminates within the host. Here, we report a unique comprehensive analysis of the impact of two Lactobacillus species, Lactobacillus paracasei CNCM I-3689 and Lactobacillus casei BL23, on L. monocytogenes and orally acquired listeriosis in a gnotobiotic humanized mouse model. We first assessed the effect of treatment with each Lactobacillus on L. monocytogenes counts in host tissues and showed that each decreases L. monocytogenes systemic dissemination in orally inoculated mice. A whole genome intestinal transcriptomic analysis revealed that each Lactobacillus changes expression of a specific subset of genes during infection, with IFN-stimulated genes (ISGs) being the most affected by both lactobacilli. We also examined microRNA (miR) expression and showed that three miRs (miR-192, miR-200b, and miR-215) are repressed during L. monocytogenes infection. Treatment with each Lactobacillus increased miR-192 expression, whereas only L. casei association increased miR-200b and miR-215 expression. Finally, we showed that treatment with each Lactobacillus significantly reshaped the L. monocytogenes transcriptome and up-regulated transcription of L. monocytogenes genes encoding enzymes allowing utilization of intestinal carbon and nitrogen sources in particular genes involved in propanediol and ethanolamine catabolism and cobalamin biosynthesis. Altogether, these data reveal that the modulation of L. monocytogenes infection by treatment with lactobacilli correlates with a decrease in host gene expression, in particular ISGs, miR regulation, and a dramatic reshaping of L. monocytogenes transcriptome. PMID:23012479

  17. Plastic Deformation of Accreted Planetesimals

    NASA Astrophysics Data System (ADS)

    Kadish, J.

    2005-08-01

    The early stages of planetesimal growth follow an accretion model (Weidenschilling, Icarus 2000), which influences the intrinsic strength of a body and may control how its shape evolves after growth. In previous work we have determined the stress field of an accreted planetesimal accounting for possible variation in the object's spin as it accretes (Kadish et al., IJSS In Press) At the end of growth, these objects are subject to transport mechanisms that can distribute them throughout the solar system. As they are transported these objects can be spun-up by tidal forces (Scheeres et al, Icarus 2000), YORP (Bottke et al., Asteroids III 2002), and collisions (Binzel et al., Asteroids II 1989). Such an increase of spin will cause perturbations to the initial stress field and may lead to failure. We are able to show analytically that failure is initiated on the object's surface and a plastic zone propagates inward as the object's spin is increased. If we model an accreted body as a conglomeration of rocks similar to a gravel or sand, the deformation in the region of failure is characterized using a Mohr-Coulomb failure criterion with negligible cohesion and zero hardening(e.g. Holsapple, Icarus 2001). Such a response is highly non-linear and must be solved using finite elements and iterative methods (Simo and Hughes, Computational Inelasticity 1998). Using the commercial finite element code ABAQUS, we present the shape deformation resulting from an elasto-plastic analysis of a spinning, self-gravitating accreted sphere that is spun-up after growth is complete. The methodology can be extended to model plastic deformation due to local failure for more complex planetesimal shapes, such as for the asteroid Kleopatra. This work has implications for the evolution of planetesimal shapes, the creation of binary and contact binary asteroids, and for the maximum spin rate of small planetary bodies.

  18. Formation Flying and Deformable Instruments

    NASA Astrophysics Data System (ADS)

    Rio, Yvon

    2009-05-01

    Astronomers have always attempted to build very stable instruments. They fight all that can cause mechanical deformation or image motion. This has led to well established technologies (autoguide, active optics, thermal control, tip/tilt correction), as well as observing methods based on the use of controlled motion (scanning, micro scanning, shift and add, chopping and nodding). Formation flying disturbs this practice. It is neither possible to reduce the relative motion to very small amplitudes, nor to control it at will. Some impacts on Simbol-X instrument design, and operation are presented.

  19. Formation Flying and Deformable Instruments

    SciTech Connect

    Rio, Yvon

    2009-05-11

    Astronomers have always attempted to build very stable instruments. They fight all that can cause mechanical deformation or image motion. This has led to well established technologies (autoguide, active optics, thermal control, tip/tilt correction), as well as observing methods based on the use of controlled motion (scanning, micro scanning, shift and add, chopping and nodding). Formation flying disturbs this practice. It is neither possible to reduce the relative motion to very small amplitudes, nor to control it at will. Some impacts on Simbol-X instrument design, and operation are presented.

  20. Dissipation in deforming chaotic billiards

    NASA Astrophysics Data System (ADS)

    Barnett, Alexander Harvey

    Chaotic billiards (hard-walled cavities) in two or more dimensions are paradigm systems in the fields of classical and quantum chaos. We study the dissipation (irreversible heating) rate in such billiard systems due to general shape deformations which are periodic in time. We are motivated by older studies of one-body nuclear dissipation and by anticipated mesoscopic applications. We review the classical and quantum linear response theories of dissipation rate and demonstrate their correspondence in the semiclassical limit. In both pictures, heating is a result of stochastic energy spreading. The heating rate can be expressed as a frequency-dependent friction coefficient μ(ω), which depends on billiard shape and deformation choice. We show that there is a special class of deformations for which μ vanishes as like a power law in the small- ω limit. Namely, for deformations which cause translations and dilations μ ~ ω4 whereas for those which cause rotations μ ~ ω2. This contrasts the generic case for which μ ~ ω4 We show how a systematic treatment of this special class leads to an improved version of the `wall formula' estimate for μ(0). We show that the special nature of dilation (a new result) is semiclassically equivalent to a quasi- orthogonality relation between the (undeformed) billiard quantum eigenstates on the boundary. This quasi- orthogonality forms the heart of a `scaling method' for the numerical calculation of quantum eigenstates, invented recently by Vergini and Saraceno. The scaling method is orders of magnitude more efficient than any other known billiard quantization method, however an adequate explanation for its success has been lacking until now. We explain the scaling method, its errors, and applications. We also present improvements to Heller's plane wave method. Two smaller projects conclude the thesis. Firstly, we give a new formalism for quantum point contact (QPC) conductance in terms of scattering cross-section in the half

  1. Deformational characteristics of thermoplastic elastomers

    NASA Astrophysics Data System (ADS)

    Indukuri, Kishore K.

    This thesis focuses primarily on the structure-property relationships of poly (styrene-ethylene-butylene-styrene) triblock copolymer TPEs. First evidence for strain-induced crystallization occurring in certain SEBS block copolymers has been established using unique techniques like deformation calorimetry, combined in-situ small angle X-ray and wide angle X-ray diffraction (SAXD/WAXD). Also the ramifications of such strain-induced crystallization on the mechanical properties like cyclic hysteresis, stress relaxation/creep retention of these SEBS systems have been studied. In addition, the structural changes in the morphology of these systems on deformation have been investigated using combined SAXD/WAXD setup. Small angle X-ray diffraction probed the changes at the nano-scale of polystyrene (PS) cylinders, while wide angle X-ray diffraction probed the changes at molecular length scales of the amorphous/crystalline domains of the elastomeric mid-block in these systems. New structural features at both these length scales have been observed and incorporated into the overall deformation mechanisms of the material. Continuous processing techniques like extrusion have been used to obtain ultra long-range order and orientation in these SEBS systems. Thus well ordered crystal like hexagonal packing of cylinders, where in each element in this hexagonal lattice can be individually addressed without any grain boundaries can be realized using these robust techniques. The effect of long-range order/orientation on the mechanical properties has been studied. In addition, these well ordered systems serve as model systems for evaluating deformation mechanisms of these SEBS systems, where the relative contributions of each of the phases can be estimated. EPDM/i-PP thermoplastic vulcanizates (TPVs) have micron size scale phase separated morphologies of EPDM rubber dispersed in a semicrystalline i-PP matrix as a result of the dynamic vulcanization process. Confocal microscopy studies

  2. Tectonic deformation in southern California

    NASA Technical Reports Server (NTRS)

    Jackson, David D.

    1993-01-01

    Our objectives were to use modem geodetic data, especially those derived from space techniques like Very Long Baseline Interferometry (VLBI), Satellite Laser Ranging (SLR), and the Global Positioning System (GPS) to infer crustal deformation in southern California and relate it to plate tectonics and earthquake hazard. To do this, we needed to collect some original data, write computer programs to determine positions of survey markers from geodetic observables, interpret time dependent positions in terms of velocity and earthquake caused episodic displacements, and construct a model to explain these velocities and displacements in terms of fault slip and plate movements.

  3. Deformable Mirrors Correct Optical Distortions

    NASA Technical Reports Server (NTRS)

    2010-01-01

    By combining the high sensitivity of space telescopes with revolutionary imaging technologies consisting primarily of adaptive optics, the Terrestrial Planet Finder is slated to have imaging power 100 times greater than the Hubble Space Telescope. To this end, Boston Micromachines Corporation, of Cambridge, Massachusetts, received Small Business Innovation Research (SBIR) contracts from the Jet Propulsion Laboratory for space-based adaptive optical technology. The work resulted in a microelectromechanical systems (MEMS) deformable mirror (DM) called the Kilo-DM. The company now offers a full line of MEMS DMs, which are being used in observatories across the world, in laser communication, and microscopy.

  4. Deformation During Friction Stir Welding

    NASA Technical Reports Server (NTRS)

    White, Henry J.

    2002-01-01

    Friction Stir Welding (FSW) is a solid state welding process that exhibits characteristics similar to traditional metal cutting processes. The plastic deformation that occurs during friction stir welding is due to the superposition of three flow fields: a primary rotation of a radially symmetric solid plug of metal surrounding the pin tool, a secondary uniform translation, and a tertiary ring vortex flow (smoke rings) surrounding the tool. If the metal sticks to the tool, the plug surface extends down into the metal from the outer edge of the tool shoulder, decreases in diameter like a funnel, and closes up beneath the pin. Since its invention, ten years have gone by and still very little is known about the physics of the friction stir welding process. In this experiment, an H13 steel weld tool (shoulder diameter, 0.797 in; pin diameter, 0.312 in; and pin length, 0.2506 in) was used to weld three 0.255 in thick plates. The deformation behavior during friction stir welding was investigated by metallographically preparing a plan view sections of the weldment and taking Vickers hardness test in the key-hole region.

  5. Thermocapillary motion of deformable drops

    NASA Astrophysics Data System (ADS)

    Haj-Hariri, Hossein; Shi, Qingping; Borhan, Ali

    1994-08-01

    The thermocapillary motion of initially spherical drops/bubbles driven by a constant temperature gradient in an unbounded liquid medium is simulated numerically. Effects of convection of momentum and energy, as well as shape deformations, are addressed. The method used is based on interface tracking on a base cartesian grid, and uses a smeared color or indicator function for the determination of the surface topology. Quad-tree adaptive refinement of the cartesian grid is implemented to enhance the fidelity of the surface tracking. It is shown that convection of energy results in a slowing of the drop, as the isotherms get wrapped around the front of the drop. Shape deformation resulting from inertial effects affect the migration velocity. The physical results obtained are in agreement with the existing literature. Furthermore, remarks are made on the sensitivity of the calculated solutions to the smearing of the fluid properties. Analysis and simulations show that the migration velocity depends very strongly on the smearing of the interfacial force whereas it is rather insensitive to the smearing of other properties, hence the adaptive grid.

  6. Deformable human body model development

    SciTech Connect

    Wray, W.O.; Aida, T.

    1998-11-01

    This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). A Deformable Human Body Model (DHBM) capable of simulating a wide variety of deformation interactions between man and his environment has been developed. The model was intended to have applications in automobile safety analysis, soldier survivability studies and assistive technology development for the disabled. To date, we have demonstrated the utility of the DHBM in automobile safety analysis and are currently engaged in discussions with the U.S. military involving two additional applications. More specifically, the DHBM has been incorporated into a Virtual Safety Lab (VSL) for automobile design under contract to General Motors Corporation. Furthermore, we have won $1.8M in funding from the U.S. Army Medical Research and Material Command for development of a noninvasive intracranial pressure measurement system. The proposed research makes use of the detailed head model that is a component of the DHBM; the project duration is three years. In addition, we have been contacted by the Air Force Armstrong Aerospace Medical Research Laboratory concerning possible use of the DHBM in analyzing the loads and injury potential to pilots upon ejection from military aircraft. Current discussions with Armstrong involve possible LANL participation in a comparison between DHBM and the Air Force Articulated Total Body (ATB) model that is the current military standard.

  7. Deformation parameters influencing prepreg tack

    SciTech Connect

    Ahn, K.J.; Seferis, J.C. ); Pelton, T.; Wilhelm, M. )

    1992-01-01

    A compression to tension apparatus and a methodology capable of measuring prepreg tack have been analyzed in detail in order to establish fundamental material and operating characteristics. Both intrinsic and extrinsic parameters influencing prepreg tack were identified and analyzed using commercially available carbon fiber/epoxy prepregs and mechanical testing equipment. Two different factors, (1) contact (or wetting) area of adjacent prepreg plies and (2) viscoelastic properties of the prepreg, were found to control prepreg tack. At low temperatures, contact area was the main deformation controlling step, while at high temperatures, the viscoelastic property of the prepreg was found to be dominant. Both interlaminar and intralaminar deformations were observed depending on the prepreg systems examined as well as the operating conditions of the test. In addition, hold time, hold pressure, loading rate, resin content, and out-time were also found to affect prepreg tack. Energy of separation, which may be viewed as a descriptor of prepreg tack, was observed to increase with increasing hold time, hold pressure, and loading rate. Energy of separation also showed a maximum value at a specific resin content for a specific prepreg system, while it decreased with increasing prepreg out-time due to prepreg surface characteristic change rather than bulk physical aging. Conclusively, it was observed that prepreg tack must be viewed as an extrinsic, bulk, but surface-sensitive, viscoelastic property which depends on material as well as operating conditions.

  8. Video model deformation system for the National Transonic Facility

    NASA Astrophysics Data System (ADS)

    Burner, A. W.; Snow, W. L.; Goad, W. K.

    1983-08-01

    A photogrammetric closed circuit television system to measure model deformation at the National Transonic Facility is described. The photogrammetric approach was chosen because of its inherent rapid data recording of the entire object field. Video cameras are used to acquire data instead of film cameras due to the inaccessibility of cameras which must be housed within the cryogenic, high pressure plenum of this facility. A rudimentary theory section is followed by a description of the video-based system and control measures required to protect cameras from the hostile environment. Preliminary results obtained with the same camera placement as planned for NTF are presented and plans for facility testing with a specially designed test wing are discussed.

  9. Deformation analysis of the Trondheim City from SAR Interferometry

    NASA Astrophysics Data System (ADS)

    Shamshiri, Roghayeh; Nahavandchi, Hossein; Motagh, Mahdi

    2016-08-01

    Trondheim is a coastal city in central Norway, which lies on the south shore of the Trondheim Fjord. Because of the river Nidelva, which runs through the city, floods, erosion and landslides, are occurring in and along theriver. Therefore, displacement monitoring of the city is important. In this study, 31 SAR images acquired in a descending track from TerraSAR-X are used to assess ground deformation in Trondheim during 2012-2014. The data is processed using InSAR time-series technique of Small BAseline Subset (SBAS) approach. The results show displacement with peak value of approx. -10 mm/yr on the coastal area and more than -5 mm/yr in the clayey areas along the river. We found that the spatial pattern of the displacement field is correlated with the deposit thickness.

  10. Video model deformation system for the National Transonic Facility

    NASA Technical Reports Server (NTRS)

    Burner, A. W.; Snow, W. L.; Goad, W. K.

    1983-01-01

    A photogrammetric closed circuit television system to measure model deformation at the National Transonic Facility is described. The photogrammetric approach was chosen because of its inherent rapid data recording of the entire object field. Video cameras are used to acquire data instead of film cameras due to the inaccessibility of cameras which must be housed within the cryogenic, high pressure plenum of this facility. A rudimentary theory section is followed by a description of the video-based system and control measures required to protect cameras from the hostile environment. Preliminary results obtained with the same camera placement as planned for NTF are presented and plans for facility testing with a specially designed test wing are discussed.

  11. Protein transfer to membranes upon shape deformation

    NASA Astrophysics Data System (ADS)

    Sagis, L. M. C.; Bijl, E.; Antono, L.; de Ruijter, N. C. A.; van Valenberg, H.

    2013-05-01

    Red blood cells, milk fat droplets, or liposomes all have interfaces consisting of lipid membranes. These particles show significant shape deformations as a result of flow. Here we show that these shape deformations can induce adsorption of proteins to the membrane. Red blood cell deformability is an important factor in several diseases involving obstructions of the microcirculatory system, and deformation induced protein adsorption will alter the rigidity of their membranes. Deformation induced protein transfer will also affect adsorption of cells onto implant surfaces, and the performance of liposome based controlled release systems. Quantitative models describing this phenomenon in biomaterials do not exist. Using a simple quantitative model, we provide new insight in this phenomenon. We present data that show convincingly that for cells or droplets with diameters upwards of a few micrometers, shape deformations induce adsorption of proteins at their interface even at moderate flow rates.

  12. Deformable mirrors development program at ESO

    NASA Astrophysics Data System (ADS)

    Stroebele, Stefan; Vernet, Elise; Brinkmann, Martin; Jakob, Gerd; Lilley, Paul; Casali, Mark; Madec, Pierre-Yves; Kasper, Markus

    2016-07-01

    Over the last decade, adaptive optics has become essential in different fields of research including medicine and industrial applications. With this new need, the market of deformable mirrors has expanded a lot allowing new technologies and actuation principles to be developed. Several E-ELT instruments have identified the need for post focal deformable mirrors but with the increasing size of the telescopes the requirements on the deformable mirrors become more demanding. A simple scaling up of existing technologies from few hundred actuators to thousands of actuators will not be sufficient to satisfy the future needs of ESO. To bridge the gap between available deformable mirrors and the future needs for the E-ELT, ESO started a development program for deformable mirror technologies. The requirements and the path to get the deformable mirrors for post focal adaptive optics systems for the E-ELT is presented.

  13. Self-adjointness of deformed unbounded operators

    SciTech Connect

    Much, Albert

    2015-09-15

    We consider deformations of unbounded operators by using the novel construction tool of warped convolutions. By using the Kato-Rellich theorem, we show that unbounded self-adjoint deformed operators are self-adjoint if they satisfy a certain condition. This condition proves itself to be necessary for the oscillatory integral to be well-defined. Moreover, different proofs are given for self-adjointness of deformed unbounded operators in the context of quantum mechanics and quantum field theory.

  14. Regularities of bainitic steel deformation transition

    NASA Astrophysics Data System (ADS)

    Gromov, V. E.; Nikitina, E. N.; Ivanov, Yu F.; Aksenova, K. V.

    2016-09-01

    Quantitative analysis of defect and carbide subsystems evolution in medium-carbon bainitic steel subjected to compressive strain up to 36% was performed by means of transmission electron diffraction microscopy. Dislocation substructure and carbide phase parameters dependence on degree of deformation are identified, possible reasons of staging in their changes are discussed. It is suggested that the reason for bainitic steel softening at high (over 15%) degrees of deformation is activation of deformation microtwinning process.

  15. Learning a hierarchical deformable template for rapid deformable object parsing.

    PubMed

    Zhu, Long Leo; Chen, Yuanhao; Yuille, Alan

    2010-06-01

    In this paper, we address the tasks of detecting, segmenting, parsing, and matching deformable objects. We use a novel probabilistic object model that we call a hierarchical deformable template (HDT). The HDT represents the object by state variables defined over a hierarchy (with typically five levels). The hierarchy is built recursively by composing elementary structures to form more complex structures. A probability distribution--a parameterized exponential model--is defined over the hierarchy to quantify the variability in shape and appearance of the object at multiple scales. To perform inference--to estimate the most probable states of the hierarchy for an input image--we use a bottom-up algorithm called compositional inference. This algorithm is an approximate version of dynamic programming where approximations are made (e.g., pruning) to ensure that the algorithm is fast while maintaining high performance. We adapt the structure-perceptron algorithm to estimate the parameters of the HDT in a discriminative manner (simultaneously estimating the appearance and shape parameters). More precisely, we specify an exponential distribution for the HDT using a dictionary of potentials, which capture the appearance and shape cues. This dictionary can be large and so does not require handcrafting the potentials. Instead, structure-perceptron assigns weights to the potentials so that less important potentials receive small weights (this is like a "soft" form of feature selection). Finally, we provide experimental evaluation of HDTs on different visual tasks, including detection, segmentation, matching (alignment), and parsing. We show that HDTs achieve state-of-the-art performance for these different tasks when evaluated on data sets with groundtruth (and when compared to alternative algorithms, which are typically specialized to each task).

  16. Consecutive Rosochatius deformations of the Neumann system

    NASA Astrophysics Data System (ADS)

    Xia, Baoqiang; Zhou, Ruguang

    2013-10-01

    Consecutive Rosochatius deformations of the Neumann system are investigated. It is first shown that different realizations of a classical sl(2) Gaudin magnet model yield different integrable Hamiltonian systems. Then an algorithm of constructing infinitely many symplectic realizations of sl(2) algebra from a known one is presented and thus the Neumann system can be deformed consecutively. The second Rosochatius deformation of the Neumann system is taken as an illustrative example to show that the deformed systems admit separations of variables and may be linearized on the Jacobi variety.

  17. Origami-enabled deformable silicon solar cells

    SciTech Connect

    Tang, Rui; Huang, Hai; Liang, Hanshuang; Liang, Mengbing; Tu, Hongen; Xu, Yong; Song, Zeming; Jiang, Hanqing; Yu, Hongyu

    2014-02-24

    Deformable electronics have found various applications and elastomeric materials have been widely used to reach flexibility and stretchability. In this Letter, we report an alternative approach to enable deformability through origami. In this approach, the deformability is achieved through folding and unfolding at the creases while the functional devices do not experience strain. We have demonstrated an example of origami-enabled silicon solar cells and showed that this solar cell can reach up to 644% areal compactness while maintaining reasonable good performance upon cyclic folding/unfolding. This approach opens an alternative direction of producing flexible, stretchable, and deformable electronics.

  18. Deformation twinning: Influence of strain rate

    SciTech Connect

    Gray, G.T. III

    1993-11-01

    Twins in most crystal structures, including advanced materials such as intermetallics, form more readily as the temperature of deformation is decreased or the rate of deformation is increased. Both parameters lead to the suppression of thermally-activated dislocation processes which can result in stresses high enough to nucleate and grow deformation twins. Under high-strain rate or shock-loading/impact conditions deformation twinning is observed to be promoted even in high stacking fault energy FCC metals and alloys, composites, and ordered intermetallics which normally do not readily deform via twinning. Under such conditions and in particular under the extreme loading rates typical of shock wave deformation the competition between slip and deformation twinning can be examined in detail. In this paper, examples of deformation twinning in the intermetallics TiAl, Ti-48Al-lV and Ni{sub 3}A as well in the cermet Al-B{sub 4}C as a function of strain rate will be presented. Discussion includes: (1) the microstructural and experimental variables influencing twin formation in these systems and twinning topics related to high-strain-rate loading, (2) the high velocity of twin formation, and (3) the influence of deformation twinning on the constitutive response of advanced materials.

  19. Early surgery for hospital-acquired and community-acquired active infective endocarditis.

    PubMed

    Shibata, Toshihiko; Sasaki, Yasuyuki; Hirai, Hidekazu; Fukui, Toshihiro; Hosono, Mitsuharu; Suehiro, Shigefumi

    2007-06-01

    Active infective endocarditis (IE) is classified into two groups; hospital acquired IE (HIE) and IE other than HIE, which was defined as community-acquired IE (CIE). Eighty-two patients underwent surgical treatment for active IE. Seventy-one cases were CIE group and eleven were HIE. There were six patients with native valve endocarditis and five cases of prosthetic valve endocarditis in the HIE group. We compared the surgical outcome of both types of active IE retrospectively. The preoperative status of the patients in the HIE group was more critical than that in the CIE group. Streptococcus spp. were the major micro-organisms in the CIE group (39%), while 82% of the HIE cases were caused by Staphylococcus spp. All Staphylococcus organisms in the HIE group were methicillin resistant. There were 10 hospital deaths, three in the CIE group and seven in the HIE group. Operative mortality in the HIE group was significantly higher than in the CIE group (63.6% vs. 4.2%, P<0.001). The outcome of early operation was satisfactory for active CIE, but poor for HIE. These types of active IE should be considered separately.

  20. [Report of 2 cases with acquired von Willebrand disease and one with acquired hemophilia A].

    PubMed

    Martínez-Murillo, C; Quintana González, S; Ambriz Fernández, R; Domínguez García, V; Rodríguez Moyado, H; Arias Aranda, A; Collazo Jaloma, J; Gutiérrez Romero, M

    1995-01-01

    We report three patients with acquired inhibitors against F VIII:C/F vW:Ag complex. Two patients had acquired hemophilia A. The three patients presented with bleeding diathesis. Case 1 was a 19 years old woman with Graves-Basedow disease; case 2 was a 40 years old woman with systemic lupus erythematosus of four years; and case 3 a 38 years old woman who had had rheumatoid arthritis for five years and was in her 3d month postpartum. The F VIII:C level was below 8 U/dL in all cases. The F vW:Ag, ristocetin cofactor and platelet aggregation with ristocetin were diminished in the two cases with von Willebrand. Inhibitor to F VIII:C was 50, 38 and 20 Bethesda units, respectively, for cases 1, 2 and 3. The three patients showed clinical response to DDAVP and cryoprecipitates with partial response in laboratory tests. All patients responded to corticosteroid treatment, but immunosuppressive treatment was necessary in case 3.

  1. SU-E-J-186: Acquiring and Assessing Upright CBCT Images for Future Treatment Planning

    SciTech Connect

    Fave, X; Yang, J; Balter, P; Court, L

    2014-06-01

    Purpose: To acquire upright CBCT images using the onboard imager of a Varian TrueBeam. An easy to implement upright imaging protocol could allow for widespread upright radiation therapy which would greatly benefit certain patients. These include thoracic cancer patients (because lung volume increases in a seated position) and patients who experience substantial discomfort during supine treatment. Methods: To acquire upright CBCT images, the gantry head remained stationary at 0 degrees with the KV imager arms extended to their lateral positions. Phantoms were placed upright at the end of the treatment couch. During a scan, the couch rotated from 270 to 90 degrees while continuous fluoroscopic projections were taken by the onboard imager. To extend the field-of-view, this sequence was performed twice: once with the KV detector longitudinally offset +14.5cm and once with it longitudinally offset −14.5cm. The resulting two image sets were stitched together before reconstruction. The imaging beam parameters were chosen to deliver a dose similar to that given during a simulation CT. Image quality was evaluated for spatial linearity, high and low contrast resolution, and HU linearity using CatPhan and anthropomorphic phantoms. A deformable registration technique was used to evaluate HU mapping from a simulation CT. Results: Spatial linearity and high contrast resolution were maintained in upright CBCT when compared to simulation CT. However, low contrast resolution and HU linearity degraded. Streak artifacts were caused by the limited 180 degree arc of the couch, and the stitching process created a sharp artifact at the center of the reconstruction. The deformable registration was robust in the HU mapping even with these artifacts and the loss of HU linearity. Conclusions: The image quality obtained from upright CBCT was sufficient for treatment planning. The success of this novel technique is an important step towards a future clinical protocol. This project was funded

  2. Effect of different heating methods on deformation of metal plate under upsetting mechanism in laser forming

    NASA Astrophysics Data System (ADS)

    Shi, Yongjun; Liu, Yancong; Yi, Peng; Hu, Jun

    2012-03-01

    In a laser forming process, different forming mechanisms have different deformation behaviors. The aim of laser forming is to acquire plane strain under an upsetting mechanism, while a plate undergoes a small bending deformation. In some industrial applications, the bending strain should not occur. To achieve high-precision forming, the deformation behaviors of a metal plate when an upsetting mechanism plays a dominant role are studied in the paper. Several heating methods are proposed to reduce the plane strain difference along the thickness direction and little bending deformation resulting from a small temperature difference between the top and bottom surfaces of the plate. The results show that negligible bending deformation and a uniform plastic plane strain field can be obtained by simultaneously heating the top and bottom surfaces with the same process parameters. A conventional scanning method needs a larger spot diameter and slower scanning speed under the upsetting mechanism, but a smaller spot diameter and quicker scanning speed may be selected using the simultaneous heating method, which can greatly widen the potential scope of process parameters.

  3. Deformed ellipsoidal diffraction grating blank

    NASA Technical Reports Server (NTRS)

    Decew, Alan E., Jr.

    1994-01-01

    The Deformed Ellipsoidal Grating Blank (DEGB) is the primary component in an ultraviolet spectrometer. Since one of the major concerns for these instruments is throughput, significant efforts are made to reduce the number of components and subsequently reflections. Each reflection results in losses through absorption and scattering. It is these two sources of photon loss that dictated the requirements for the DEGB. The first goal is to shape the DEGB in such a way that the energy at the entrance slit is focused as well as possible on the exit slit. The second goal is to produce a surface smooth enough to minimize the photon loss due to scattering. The program was accomplished in three phases. The first phase was the fabrication planning. The second phase was the actual fabrication and initial testing. The last phase was the final testing of the completed DEGB.

  4. Deformation in the continental lithosphere

    NASA Astrophysics Data System (ADS)

    The Physical Properties of Earth Materials Committee, a technical committee of AGU's Tectonophysics Section, is organizing a dinner/colloquium as part of the Fall Meeting in San Francisco, Calif. This event will be held Monday, December 3rd, in the Gold Rush Room of the Holiday Inn Golden Gateway Hotel at 1500 Van Ness St. There will be a no-host bar from 6:30 to 7:30 P.M., followed by dinner from 7:30 to 8:30 P.M. Paul Tapponnier will deliver the after-dinner talk, “Large-Scale Deformation Mechanisms in the Continental Lithosphere: Where Do We Stand?” It will start at 8:30 P.M. and a business meeting will follow at 9:30 P.M.

  5. Deformation quantization of fermi fields

    SciTech Connect

    Galaviz, I. Garcia-Compean, H. Przanowski, M. Turrubiates, F.J.

    2008-04-15

    Deformation quantization for any Grassmann scalar free field is described via the Weyl-Wigner-Moyal formalism. The Stratonovich-Weyl quantizer, the Moyal *-product and the Wigner functional are obtained by extending the formalism proposed recently in [I. Galaviz, H. Garcia-Compean, M. Przanowski, F.J. Turrubiates, Weyl-Wigner-Moyal Formalism for Fermi Classical Systems, arXiv:hep-th/0612245] to the fermionic systems of infinite number of degrees of freedom. In particular, this formalism is applied to quantize the Dirac free field. It is observed that the use of suitable oscillator variables facilitates considerably the procedure. The Stratonovich-Weyl quantizer, the Moyal *-product, the Wigner functional, the normal ordering operator, and finally, the Dirac propagator have been found with the use of these variables.

  6. Subtle hippocampal deformities in breast cancer survivors with reduced episodic memory and self-reported cognitive concerns.

    PubMed

    Apple, Alexandra C; Ryals, Anthony J; Alpert, Kathryn I; Wagner, Lynne I; Shih, Pei-An; Dokucu, Mehmet; Cella, David; Penedo, Frank J; Voss, Joel L; Wang, Lei

    2017-01-01

    Cancer survivors have lingering cognitive problems, however the anatomical basis for these problems has yet to be fully elucidated. Clinical studies as well as animal models of chemotherapy have pinpointed cell and volume loss to the hippocampus, however, few studies have performed shape analysis of the hippocampus on cancer survivors. This study used high-dimensional deformation mapping analysis to test whether localized hippocampal deformation differs in breast cancer survivors who received adjuvant chemotherapy coupled with hormone blockade therapy, and if deformation was related to subjective self-reported concerns and cognitive performance. 3 T MRI images were acquired from 16 pre-menopausal breast cancer survivors and 18 healthy controls without a history of cancer. Breast cancer survivors had undergone chemotherapy within the eighteen months prior to the study, and were receiving estrogen-blockade therapy at the time of the study. Automated high-dimensional deformation mapping was used to compare localized hippocampal deformation differences between groups. Self-reported subjective concerns were assessed using Neuro-QOL Cognitive Function assessment, whereas cognitive performance was evaluated using the NIH Toolbox Cognition Battery. Relative to healthy controls, cancer survivors showed significantly more inward hippocampal deformation, worse self-reported cognitive functioning, and inferior episodic memory test score. This study is the first of its kind to examine the relationship between hippocampal deformity and cognitive impairment in cancer survivors.

  7. Incorporating tissue excision in deformable image registration: a modified demons algorithm for cone-beam CT-guided surgery

    NASA Astrophysics Data System (ADS)

    Nithiananthan, S.; Mirota, D.; Uneri, A.; Schafer, S.; Otake, Y.; Stayman, J. W.; Siewerdsen, J. H.

    2011-03-01

    The ability to perform fast, accurate, deformable registration with intraoperative images featuring surgical excisions was investigated for use in cone-beam CT (CBCT) guided head and neck surgery. Existing deformable registration methods generally fail to account for tissue excised between image acquisitions and typically simply "move" voxels within the images with no ability to account for tissue that is removed (or introduced) between scans. We have thus developed an approach in which an extra dimension is added during the registration process to act as a sink for voxels removed during the course of the procedure. A series of cadaveric images acquired using a prototype CBCT-capable C-arm were used to model tissue deformation and excision occurring during a surgical procedure, and the ability of deformable registration to correctly account for anatomical changes under these conditions was investigated. Using a previously developed version of the Demons deformable registration algorithm, we identify the difficulties that traditional registration algorithms encounter when faced with excised tissue and present a modified version of the algorithm better suited for use in intraoperative image-guided procedures. Studies were performed for different deformation and tissue excision tasks, and registration performance was quantified in terms of the ability to accurately account for tissue excision while avoiding spurious deformations arising around the excision.

  8. Deformation and seismicity of Taiwan.

    PubMed

    Vita-Finzi, C

    2000-10-10

    14C-dated Holocene coastal uplift, conventional and satellite geodetic measurements, and coseismic and aseismic fault slip reveal the pattern of distributed deformation at Taiwan resulting from convergence between the Philippine Sea plate and Eurasia; as in other subduction orogenic settings, the locus of strain release and accumulation is strongly influenced by changes in fault geometry across strike. Uplift evidence from the islands of Lutao and Lanhsu is consistent with progressive oblique collision between the Luzon arc and the Chinese continental margin. In the Coastal Range, geodetic and seismic records show that shortening is taken up serially by discontinuous slip on imbricate faults. The geodetic data point to net extension across the Central Range, but deformed Holocene shorelines in the Hengchun Peninsula at its southern extremity suggest that the extension is a superficial effect partly caused by blind reverse faulting. The fastest shortening rates indicated by geodesy are recorded on the Longitudinal Valley fault and across the Chukou fault within the fold-and-thrust belt. In the former, the strain is dissipated mainly as aseismic reverse and strike-slip displacement. In contrast, the fold-and-thrust belt has witnessed five earthquakes with magnitudes of 6.5 or above in the 20th century, including the 1999.9.21 Chi-Chi earthquake (magnitude approximately 7.6) on a branch of the Chukou fault. The neotectonic and geodetic data for Taiwan as a whole suggest that the fold-and-thrust belt will continue to host the majority of great earthquakes on the island.

  9. Persistent scatterers detection on synthetic aperture radar images acquired by Sentinel-1 satellite

    NASA Astrophysics Data System (ADS)

    Dǎnişor, Cosmin; Popescu, Anca; Datcu, Mihai

    2016-12-01

    Persistent Scatterers Interferometry (PS-InSAR) has become a popular method in remote sensing because of its capability to measure terrain deformations with very high accuracy. It relies on multiple Synthetic Aperture Radar (SAR) acquisitions, to monitor points with stable proprieties over time, called Persistent Scatterers (PS)[1]. These points are unaffected by temporal decorrelation, therefore by analyzing their interferometric phase variation we can estimate the scene's deformation rates within a given time interval. In this work, we apply two incoherent detection algorithms to identify Persistent Scatterers candidates in the city of Focșani, Romania. The first method studies the variation of targets' intensities along the SAR acquisitions and the second method analyzes the spectral proprieties of the scatterers. The algorithms were implemented on a dataset containing 11 complex images of the region covering Buzău, Brăila and Focșani cities. Images were acquired by Sentinel-1 satellite in a time span of 5 months, from October 2014 to February 2015. The processing chain follows the requirements imposed by the new C-band SAR images delivered by the Sentinel-1 satellite (launched in April 2014) imaging in Interferometric Wide (IW) mode. Considering the particularities of the TOPS (Terrain Observation with Progressive Scans in Azimuth) imaging mode[2], special requirements had to be considered for pre-processing steps. The PS detection algorithms were implemented in Gamma RS program, a software which contains various function packages dedicated to SAR images focalization, analysis and processing.

  10. Reconstructive Approach to an Acquired Absence of Multiple Facial Components: A Case Report

    PubMed Central

    Oliver, Lauren N.

    2016-01-01

    Summary: The subject of our case report is a young girl who was attacked by a raccoon when she was 5 months old. She lost the majority of her nose, her entire right ear, and part of her upper lip. She had previous attempts at reconstructive surgery with poor results. Our collective goals were to provide lifelong reconstruction without the use of synthetic implants and to organize the steps in a way that provided psychological benefit early on while allowing her to continue education and childhood activities with minimal disruptions. We approached the patient’s many problems in stages by starting with the most obvious deformity and progressing to the least severe deformity. A radial forearm free flap and a forehead flap with rib cartilage were used in stages for nasal reconstruction. An Abbé flap was utilized for lip reconstruction, and a prelaminated radial forearm free flap with a costal cartilage frame was selected to form a new ear. She had neither lasting complications nor any morbidity from her donor sites. She and her family report a drastic improvement in her self-confidence and in her interactions with her peers. A stepwise approach to reconstruction of acquired absence of multiple facial components achieves the benefit of early positive psychological results with necessary breaks from surgery to allow her normal childhood activities and education. Judicious utilization of free flaps negates the need of synthetic implants for lifelong reconstruction. PMID:27826477

  11. 33 CFR 211.2 - Authority to acquire real estate.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... PROJECTS Real Estate; General § 211.2 Authority to acquire real estate. (a) Congressional authority... of the Army to acquire real estate for river and harbor improvements, flood control projects and allied purposes, is based upon enactments of the Congress authorizing the particular projects...

  12. Safety and Efficacy of Antimicrobial Peptides against Naturally Acquired Leishmaniasis

    PubMed Central

    Alberola, J.; Rodríguez, A.; Francino, O.; Roura, X.; Rivas, L.; Andreu, D.

    2004-01-01

    Leishmaniases, which are important causes of morbidity and mortality in humans and dogs, are extremely difficult to treat. Antimicrobial peptides are rarely used as alternative treatments for naturally acquired parasitic diseases. Here we report that the acylated synthetic antimicrobial peptide Oct-CA(1-7)M(2-9) is safe and effective for treating naturally acquired canine leishmaniasis. PMID:14742227

  13. 14 CFR 1274.402 - Contractor acquired property.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Contractor acquired property. 1274.402 Section 1274.402 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION COOPERATIVE AGREEMENTS WITH COMMERCIAL FIRMS Property § 1274.402 Contractor acquired property. As provided in §...

  14. Acquiring Knowledge of Derived Nominals and Derived Adjectives in Context

    ERIC Educational Resources Information Center

    Marinellie, Sally A.; Kneile, Lynn A.

    2012-01-01

    Purpose: This research investigated children's ability to acquire semantic and syntactic knowledge of derived nominals and derived adjectives in the context of short passages. The study also investigated the relation of morphological awareness and the ability to acquire knowledge of derived words in context. Method: A total of 106 children in…

  15. 34 CFR 7.4 - Option to acquire foreign rights.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Option to acquire foreign rights. 7.4 Section 7.4 Education Office of the Secretary, Department of Education EMPLOYEE INVENTIONS § 7.4 Option to acquire foreign rights. In any case where it is determined that all domestic rights should be assigned to...

  16. 43 CFR 3471.4 - Future interest, acquired lands.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Future interest, acquired lands. 3471.4 Section 3471.4 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND... Coal Management Provisions and Limitations § 3471.4 Future interest, acquired lands. An application...

  17. 19 CFR 148.33 - Articles acquired abroad.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Articles acquired abroad. 148.33 Section 148.33... Articles acquired abroad. (a) Exemption. Each returning resident is entitled to bring in free of duty and..., Harmonized Tariff Schedule of the United States (19 U.S.C. 1202), articles for his personal or household...

  18. 19 CFR 148.33 - Articles acquired abroad.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Articles acquired abroad. 148.33 Section 148.33... Articles acquired abroad. (a) Exemption. Each returning resident is entitled to bring in free of duty and..., Harmonized Tariff Schedule of the United States (19 U.S.C. 1202), articles for his personal or household...

  19. 19 CFR 148.33 - Articles acquired abroad.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 2 2014-04-01 2014-04-01 false Articles acquired abroad. 148.33 Section 148.33... Articles acquired abroad. (a) Exemption. Each returning resident is entitled to bring in free of duty and..., Harmonized Tariff Schedule of the United States (19 U.S.C. 1202), articles for his personal or household...

  20. 19 CFR 148.33 - Articles acquired abroad.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Articles acquired abroad. 148.33 Section 148.33... Articles acquired abroad. (a) Exemption. Each returning resident is entitled to bring in free of duty and..., Harmonized Tariff Schedule of the United States (19 U.S.C. 1202), articles for his personal or household...

  1. 19 CFR 148.33 - Articles acquired abroad.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Articles acquired abroad. 148.33 Section 148.33... Articles acquired abroad. (a) Exemption. Each returning resident is entitled to bring in free of duty and..., Harmonized Tariff Schedule of the United States (19 U.S.C. 1202), articles for his personal or household...

  2. 33 CFR 211.2 - Authority to acquire real estate.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Authority to acquire real estate..., DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN CONNECTION WITH CIVIL WORKS PROJECTS Real Estate; General § 211.2 Authority to acquire real estate. (a) Congressional...

  3. 33 CFR 211.27 - Method of acquiring Federal jurisdiction.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN CONNECTION WITH CIVIL WORKS PROJECTS Federal Jurisdiction over Real Estate § 211.27 Method of acquiring Federal jurisdiction. Jurisdiction is acquired in accordance with the laws of the various States....

  4. Acquired Clitoromegaly: A Gynaecological Problem or an Obstetric Complication?

    PubMed Central

    Saini, Vandana; Poddar, Anju; Kumari, Supriya; Maitra, Ashesh

    2016-01-01

    Acquired non-hormonal clitoromegaly is a rare condition and is due to benign or malignant tumours and sometimes idiopathic. Few cases of clitoral abscesses have been reported after female circumcision. We hereby report a case of clitoral abscess causing acquired clitoromegaly following an obstetrical surgery. PMID:28208951

  5. 45 CFR 7.4 - Option to acquire foreign rights.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Option to acquire foreign rights. 7.4 Section 7.4 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION EMPLOYEE INVENTIONS § 7.4 Option to acquire foreign rights. In any case where it is determined that all domestic rights should be assigned to the Government, it...

  6. Free Reading: A Powerful Tool for Acquiring a Second Language

    ERIC Educational Resources Information Center

    Priya, J.; Ponniah, R. Joseph

    2013-01-01

    The paper claims that free reading is a crucial ingredient in acquiring a second or foreign language. It contributes to the development of all measures of language competence which include grammar, vocabulary, spelling, syntax, fluency and style. The review supports the claim that readers acquire language subconsciously when they receive…

  7. 43 CFR 3101.2-2 - Acquired lands.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Acquired lands. 3101.2-2 Section 3101.2-2 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... Acquired lands. An acreage limitation separate from, but equal to the acreage limitation for public...

  8. 43 CFR 3101.2-2 - Acquired lands.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Acquired lands. 3101.2-2 Section 3101.2-2 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... Acquired lands. An acreage limitation separate from, but equal to the acreage limitation for public...

  9. 43 CFR 3101.2-2 - Acquired lands.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Acquired lands. 3101.2-2 Section 3101.2-2 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... Acquired lands. An acreage limitation separate from, but equal to the acreage limitation for public...

  10. 43 CFR 3110.5-3 - Acquired lands.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Acquired lands. 3110.5-3 Section 3110.5-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... Acquired lands. (a) If the lands applied for lie within and conform to the rectangular system of...

  11. 43 CFR 3110.5-3 - Acquired lands.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Acquired lands. 3110.5-3 Section 3110.5-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... Acquired lands. (a) If the lands applied for lie within and conform to the rectangular system of...

  12. 43 CFR 3110.5-3 - Acquired lands.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Acquired lands. 3110.5-3 Section 3110.5-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... Acquired lands. (a) If the lands applied for lie within and conform to the rectangular system of...

  13. 43 CFR 3110.5-3 - Acquired lands.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Acquired lands. 3110.5-3 Section 3110.5-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... Acquired lands. (a) If the lands applied for lie within and conform to the rectangular system of...

  14. 43 CFR 3101.2-2 - Acquired lands.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Acquired lands. 3101.2-2 Section 3101.2-2 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... Acquired lands. An acreage limitation separate from, but equal to the acreage limitation for public...

  15. 26 CFR 1.471-9 - Inventories of acquiring corporations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 6 2011-04-01 2011-04-01 false Inventories of acquiring corporations. 1.471-9 Section 1.471-9 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Inventories § 1.471-9 Inventories of acquiring...

  16. 26 CFR 1.472-7 - Inventories of acquiring corporations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 6 2011-04-01 2011-04-01 false Inventories of acquiring corporations. 1.472-7 Section 1.472-7 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Inventories § 1.472-7 Inventories of acquiring...

  17. Botulinum toxin in the management of acquired motor fusion deficiency

    PubMed Central

    Murthy, Ramesh; Kesarwani, Siddharth

    2009-01-01

    Acquired disruption of motor fusion is a rare condition characterized by intractable diplopia. Management of these patients is extremely difficult. Prisms in any combination or even surgery may not help relieve their symptoms. We describe a longstanding case of acquired motor fusion disruption which was managed successfully with botulinum toxin injection. PMID:19861751

  18. 27 CFR 6.45 - Assistance in acquiring license.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Assistance in acquiring license. 6.45 Section 6.45 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS âTIED-HOUSEâ Unlawful Inducements Furnishing Things of Value § 6.45 Assistance in acquiring license....

  19. 26 CFR 1.471-9 - Inventories of acquiring corporations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 6 2010-04-01 2010-04-01 false Inventories of acquiring corporations. 1.471-9 Section 1.471-9 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Inventories § 1.471-9 Inventories of acquiring corporations....

  20. 26 CFR 1.472-7 - Inventories of acquiring corporations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 6 2010-04-01 2010-04-01 false Inventories of acquiring corporations. 1.472-7 Section 1.472-7 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Inventories § 1.472-7 Inventories of acquiring corporations....

  1. 26 CFR 1.9002-6 - Acquiring corporation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Acquiring corporation. 1.9002-6 Section 1.9002... (CONTINUED) INCOME TAXES General Actuarial Valuations § 1.9002-6 Acquiring corporation. Section 5(d) of the... corporation by another corporation in a distribution or transfer described in section 381(a) of the Code...

  2. Surface Deformation and Coherence Measurements of Kilauea Volcano, Hawaii, from SIR-C Radar Interferometry

    NASA Technical Reports Server (NTRS)

    Rosen, P. A.; Hensley, S.; Zebker, H. A.; Webb, F. H.; Fielding, E. J.

    1996-01-01

    The shuttle imaging radar C/X synthetic aperture radar (SIR-C/X-SAR) radar on board the space shuttle Endeavor imaged Kilauea Volcano, Hawaii, in April and October 1994 for the purpose of measuring active surface deformation by the methods of repeat-pass differential radar interferometry. Observations at 24 cm (L band) and 5.6 cm (C band) wavelengths were reduced to interferograms showing apparent surface deformation over the 6-month interval and over a succession of 1-day intervals in October. A statistically significant local phase signature in the 6-month interferogram is coincident with the Pu'u O'o lava vent. Interpreted as deformation, the signal implies centimeter-scale deflation in an area several kilometers wide surrounding the vent. Peak deflation is roughly 14 cm if the deformation is purely vertical, centered southward of the Pu'u O'o caldera. Delays in the radar signal phase induced by atmospheric refractivity anomalies introduce spurious apparent deformation signatures, at the level of 12 cm peak-to-peak in the radar line-of-sight direction. Though the phase observations are suggestive of the wide-area deformation measured by Global Positioning System (GPS) methods, the atmospheric effects are large enough to limit the interpretation of the result. It is difficult to characterize centimeter-scale deformations spatially distributed over tens of kilometers using differential interferometry without supporting simultaneous, spatially distributed measurements of reactivity along the radar line of sight. Studies of the interferometric correlation of images acquired at different times show that L band is far superior to C band in the vegetated areas, even when the observations are separated by only 1 day. These results imply longer wavelength instruments are more appropriate for studying surfaces by repeat-pass observations.

  3. Surface deformation adjacent to the Hukou fault in Northwestern Taiwan detected by ENVISAT ASAR interferometry

    NASA Astrophysics Data System (ADS)

    Chang, Y.; Chang, C.

    2007-12-01

    The Taiwan Island, which is young, as revealed by its dense seismic activities and rapid surface deformation, is located at the convergent zone between Eurasia plate and Philippine Sea plate. Because of the continued northwestward movement of the Philippine Sea plate and the active extension of the Okinawa Trough, the northern part of Taiwan is now under deformation. Since the northern Taiwan is the most populated area in Taiwan, the tectonic activity and the potential geological hazard of this area is an important issue for Taiwan. In order to realize the surface deformation behavior of this area, we apply DInSAR-technique to engage this study. The Hukou fault, main focus of this study, is one of the major and active structures in northwestern Taiwan, along which some industrial parks and communities are well developed. The SAR images used in this study are all acquired from 2003 to 2007 by ENVISAT satellite, which is launched by the European Space Agency in 2002. Our preliminary interferometric results reveal that the surface deformation in the urban areas are much clear than that in mountainous and rural areas. In some areas, juxtaposed against the fault zones, clear deformation patterns are obviously observed indicates that the deformation of this area is still active. After stacking all our interferometric results, we obtain that the average slant range displacement (SRD) reaches to around 0.5 cm/yr near the fault area. Radar Interferometry can efficiently be applied to observe the land surface deformation, and further help us to interpret and predict the underground tectonics and potential natural hazard.

  4. Dynamic Deformation Measurements of an Aeroelastic Semispan Model. [conducted in the Transonic Dynamics Tunnel at the NASA Langley Research Center

    NASA Technical Reports Server (NTRS)

    Graves, Sharon S.; Burner, Alpheus W.; Edwards, John W.; Schuster, David M.

    2001-01-01

    The techniques used to acquire, reduce, and analyze dynamic deformation measurements of an aeroelastic semispan wind tunnel model are presented. Single-camera, single-view video photogrammetry (also referred to as videogrammetric model deformation, or VMD) was used to determine dynamic aeroelastic deformation of the semispan 'Models for Aeroelastic Validation Research Involving Computation' (MAVRIC) model in the Transonic Dynamics Tunnel at the NASA Langley Research Center. Dynamic deformation was determined from optical retroreflective tape targets at five semispan locations located on the wing from the root to the tip. Digitized video images from a charge coupled device (CCD) camera were recorded and processed to automatically determine target image plane locations that were then corrected for sensor, lens, and frame grabber spatial errors. Videogrammetric dynamic data were acquired at a 60-Hz rate for time records of up to 6 seconds during portions of this flutter/Limit Cycle Oscillation (LCO) test at Mach numbers from 0.3 to 0.96. Spectral analysis of the deformation data is used to identify dominant frequencies in the wing motion. The dynamic data will be used to separate aerodynamic and structural effects and to provide time history deflection data for Computational Aeroelasticity code evaluation and validation.

  5. Solute transport through a deforming porous medium

    NASA Astrophysics Data System (ADS)

    Peters, Glen P.; Smith, David W.

    2002-06-01

    Solute transport through a porous medium is typically modelled assuming the porous medium is rigid. However, many applications exist where the porous medium is deforming, including, municipal landfill liners, mine tailings dams, and land subsidence. In this paper, mass balance laws are used to derive the flow and transport equations for a deforming porous medium. The equations are derived in both spatial and material co-ordinate systems. Solute transport through an engineered landfill liner is used as an illustrative example to show the differences between the theory for a rigid porous medium, and small and large deformation analysis of a deforming porous medium. It is found that the large deformation model produces shorter solute breakthrough times, followed by the small deformation model, and then the rigid porous medium model. It is also found that it is important to include spatial and temporal void ratio variations in the large deformation analysis. It is shown that a non-linear large deformation model may greatly reduce the solute breakthrough time, compared to a standard transport analysis typically employed by environmental engineers.

  6. Measuring Viscoelastic Deformation with an Optical Mouse

    ERIC Educational Resources Information Center

    Ng, T. W.

    2004-01-01

    The feasibility of using an optical mouse to track the viscoelastic deformation of low-density polyethylene films that have a fixed attached load is presented. It is seen that using an optical mouse and with rudimentary experiment paraphernalia and arrangement, it is possible to get good measurements of viscoelastic deformation.

  7. Plastic deformation mechanisms in nanocrystalline metallic materials

    NASA Astrophysics Data System (ADS)

    Ovid'ko, Ilya A.

    2013-11-01

    This article discusses the experiments, computer simulations, and theoretical models addressing the conventional and specific mechanisms of plastic deformation in nanocrystalline metallic materials. Particular attention is devoted to the competition between lattice dislocation slip and specific deformation mechanisms mediated by grain boundaries as well as its sensitivity to grain size and other parameters of nanocrystalline metallic structures.

  8. Quantification of abdominal aortic deformation after EVAR

    NASA Astrophysics Data System (ADS)

    Demirci, Stefanie; Manstad-Hulaas, Frode; Navab, Nassir

    2009-02-01

    Quantification of abdominal aortic deformation is an important requirement for the evaluation of endovascular stenting procedures and the further refinement of stent graft design. During endovascular aortic repair (EVAR) treatment, the aortic shape is subject to severe deformation that is imposed by medical instruments such as guide wires, catheters, and, the stent graft. This deformation can affect the flow characteristics and morphology of the aorta which have been shown to be elicitors for stent graft failures and be reason for reappearance of aneurysms. We present a method for quantifying the deformation of an aneurysmatic aorta imposed by an inserted stent graft device. The outline of the procedure includes initial rigid alignment of the two abdominal scans, segmentation of abdominal vessel trees, and automatic reduction of their centerline structures to one specified region of interest around the aorta. This is accomplished by preprocessing and remodeling of the pre- and postoperative aortic shapes before performing a non-rigid registration. We further narrow the resulting displacement fields to only include local non-rigid deformation and therefore, eliminate all remaining global rigid transformations. Finally, deformations for specified locations can be calculated from the resulting displacement fields. In order to evaluate our method, experiments for the extraction of aortic deformation fields are conducted on 15 patient datasets from endovascular aortic repair (EVAR) treatment. A visual assessment of the registration results and evaluation of the usage of deformation quantification were performed by two vascular surgeons and one interventional radiologist who are all experts in EVAR procedures.

  9. Umbral Deformations on Discrete SPACE TIME

    NASA Astrophysics Data System (ADS)

    Zachos, Cosmas K.

    Given a minimum measurable length underlying spacetime, the latter may be effectively regarded as discrete, at scales of order the Planck length. A systematic discretization of continuum physics may be effected most efficiently through the umbral deformation. General functionals yielding such deformations at the level of solutions are furnished and illustrated, and broad features of discrete oscillations and wave propagation are outlined.

  10. Exploiting Adaptive Optics with Deformable Secondary Mirrors

    DTIC Science & Technology

    2007-03-08

    progress in tomographic wavefront sensing and altitude conjugated adaptive correction, and is a critical step forward for adaptive optics for future large...geostationary satellites, captured at the 6.5 m MMT telescope, using the deformable secondary adaptive optics system....new technology to the unique development of deformable secondary mirrors pioneered at the University of Arizona’s Center for Astronomical Adaptive

  11. 7 CFR 51.1013 - Badly deformed.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946... Standards for Persian (Tahiti) Limes Definitions § 51.1013 Badly deformed. Badly deformed means that...

  12. SU-E-J-241: Creation of Ventilation CT From Daily 4D CTs Or 4D Conebeam CTs Acquired During IGRT for Thoracic Cancers

    SciTech Connect

    Tai, A; Ahunbay, E; Li, X

    2014-06-01

    Purpose: To develop a method to create ventilation CTs from daily 4D CTs or 4D KV conebeam CTs (4DCBCT) acquired during image-guided radiation therapy (IGRT) for thoracic tumors, and to explore the potential for using the ventilation CTs as a means for early detection of lung injury during radiation treatment. Methods: 4DCT acquired using an in-room CT (CTVision, Siemens) and 4DCBCT acquired using the X-ray Volume Imaging (XVI) system (Infinity, Elekta) for representative lung cancer patients were analyzed. These 4D data sets were sorted into 10 phase images. A newly-available deformable image registration tool (ADMIRE, Elekta) is used to deform the phase images at the end of exhale (EE) to the phase images at the end of inhale (EI). The lung volumes at EI and EE were carefully contoured using an intensity-based auto-contour tool and then manually edited. The ventilation images were calculated from the variations of CT numbers of those voxels masked by the lung contour at EI between the registered phase images. The deformable image registration is also performed between the daily 4D images and planning 4DCT, and the resulting deformable field vector (DFV) is used to deform the planning doses to the daily images by an in-house Matlab program. Results: The ventilation images were successfully created. The tide volumes calculated using the ventilation images agree with those measured through volume difference of contours at EE and EI, indicating the accuracy of ventilation images. The association between the delivered doses and the change of lung ventilation from the daily ventilation CTs is identified. Conclusions: A method to create the ventilation CT using daily 4DCTs or 4D KV conebeam CTs was developed and demonstrated.

  13. Nilpotent deformations of N = 2 superspace

    NASA Astrophysics Data System (ADS)

    Ivanov, Evgeny; Zupnik, Boris; Lechtenfeld, Olaf

    2004-02-01

    We investigate deformations of four-dimensional N = (1,1) euclidean superspace induced by nonanticommuting fermionic coordinates. We essentially use the harmonic superspace approach and consider nilpotent bi-differential Poisson operators only. One variant of such deformations (termed chiral nilpotent) directly generalizes the recently studied chiral deformation of N = (1/2,1/2) superspace. It preserves chirality and harmonic analyticity but generically breaks N = (1,1) to N = (1,0) supersymmetry. Yet, for degenerate choices of the constant deformation matrix N = (1,1/2) supersymmetry can be retained, i.e. a fraction of 3/4. An alternative version (termed analytic nilpotent) imposes minimal nonanticommutativity on the analytic coordinates of harmonic superspace. It does not affect the analytic subspace and respects all supersymmetries, at the expense of chirality however. For a chiral nilpotent deformation, we present non(anti)commutative euclidean analogs of N = 2 Maxwell and hypermultiplet off-shell actions.

  14. Performance of 12 DIR algorithms in low-contrast regions for mass and density conserving deformation

    SciTech Connect

    Yeo, U. J.; Supple, J. R.; Franich, R. D.; Taylor, M. L.; Smith, R.; Kron, T.

    2013-10-15

    Purpose: Deformable image registration (DIR) has become a key tool for adaptive radiotherapy to account for inter- and intrafraction organ deformation. Of contemporary interest, the application to deformable dose accumulation requires accurate deformation even in low contrast regions where dose gradients may exist within near-uniform tissues. One expects high-contrast features to generally be deformed more accurately by DIR algorithms. The authors systematically assess the accuracy of 12 DIR algorithms and quantitatively examine, in particular, low-contrast regions, where accuracy has not previously been established.Methods: This work investigates DIR algorithms in three dimensions using deformable gel (DEFGEL) [U. J. Yeo, M. L. Taylor, L. Dunn, R. L. Smith, T. Kron, and R. D. Franich, “A novel methodology for 3D deformable dosimetry,” Med. Phys. 39, 2203–2213 (2012)], for application to mass- and density-conserving deformations. CT images of DEFGEL phantoms with 16 fiducial markers (FMs) implanted were acquired in deformed and undeformed states for three different representative deformation geometries. Nonrigid image registration was performed using 12 common algorithms in the public domain. The optimum parameter setup was identified for each algorithm and each was tested for deformation accuracy in three scenarios: (I) original images of the DEFGEL with 16 FMs; (II) images with eight of the FMs mathematically erased; and (III) images with all FMs mathematically erased. The deformation vector fields obtained for scenarios II and III were then applied to the original images containing all 16 FMs. The locations of the FMs estimated by the algorithms were compared to actual locations determined by CT imaging. The accuracy of the algorithms was assessed by evaluation of three-dimensional vectors between true marker locations and predicted marker locations.Results: The mean magnitude of 16 error vectors per sample ranged from 0.3 to 3.7, 1.0 to 6.3, and 1.3 to 7

  15. The properties of Q-deformed hyperbolic and trigonometric functions in quantum deformation

    SciTech Connect

    Deta, U. A. E-mail: utamadeta@unesa.ac.id; Suparmi

    2015-09-30

    Quantum deformation has been studied due to its relation with applications in nuclear physics, conformal field theory, and statistical-quantum theory. The q-deformation of hyperbolic function was introduced by Arai. The application of q-deformed functions has been widely used in quantum mechanics. The properties of this two kinds of system explained in this paper including their derivative. The graph of q-deformed functions presented using Matlab. The special case is given for modified Poschl-Teller plus q-deformed Scarf II trigonometry potentials.

  16. Inelastic deformation and dislocation structure of a nickel alloy - Effects of deformation and thermal histories

    NASA Technical Reports Server (NTRS)

    Chan, K. S.; Page, R. A.

    1988-01-01

    Inelastic deformation behavior of the cast Ni-base alloy, B1900 + Hf, was investigated using data from step-temperature tensile tests and thermomechanical cyclic tests in the temperature ranges 538-760 C and 760-982 C. The deformation results were correlated with the dislocation structures of deformed specimens, identified by TEM. It was found that, in the 760-982 C temperature range, there are no thermal history effects in the inelastic deformation behavior of B1900 + Hf. In the 538-760 range, anomalous cyclic hardening and, possibly, thermal history effects were observed in thermomechanically deformed alloy, caused by sessile (010) dislocations in the gamma-prime phase.

  17. Large Deformations of a Soft Porous Material

    NASA Astrophysics Data System (ADS)

    MacMinn, Christopher W.; Dufresne, Eric R.; Wettlaufer, John S.

    2016-04-01

    Compressing a porous material will decrease the volume of the pore space, driving fluid out. Similarly, injecting fluid into a porous material can expand the pore space, distorting the solid skeleton. This poromechanical coupling has applications ranging from cell and tissue mechanics to geomechanics and hydrogeology. The classical theory of linear poroelasticity captures this coupling by combining Darcy's law with Terzaghi's effective stress and linear elasticity in a linearized kinematic framework. Linear poroelasticity is a good model for very small deformations, but it becomes increasingly inappropriate for moderate to large deformations, which are common in the context of phenomena such as swelling and damage, and for soft materials such as gels and tissues. The well-known theory of large-deformation poroelasticity combines Darcy's law with Terzaghi's effective stress and nonlinear elasticity in a rigorous kinematic framework. This theory has been used extensively in biomechanics to model large elastic deformations in soft tissues and in geomechanics to model large elastoplastic deformations in soils. Here, we first provide an overview and discussion of this theory with an emphasis on the physics of poromechanical coupling. We present the large-deformation theory in an Eulerian framework to minimize the mathematical complexity, and we show how this nonlinear theory simplifies to linear poroelasticity under the assumption of small strain. We then compare the predictions of linear poroelasticity with those of large-deformation poroelasticity in the context of two uniaxial model problems: fluid outflow driven by an applied mechanical load (the consolidation problem) and compression driven by a steady fluid throughflow. We explore the steady and dynamical errors associated with the linear model in both situations, as well as the impact of introducing a deformation-dependent permeability. We show that the error in linear poroelasticity is due primarily to kinematic

  18. Tracking of object deformations in color and depth video: deformation models and applications

    NASA Astrophysics Data System (ADS)

    Jordt, Andreas; Reinhold, Stefan; Koch, Reinhard

    2015-05-01

    The research on deformation tracking based on color image data has continuously gained a wide interest in the last 15 years. In addition, using depth sensors such as the Microsoft Kinect, allows to mitigate the ambiguity problems that arise when trying to solve the deformation tracking tasks on color images only, by adding depth information. However, the fusion of color and depth data is not straight forward, and the deformation tracking task is still ill-posed due to the lack of a general deformation model. The problem is usually circumvented by providing special deformation functions for the task at hand, e.g., skeleton-based for reconstructing people or triangle-based for tracking planar surfaces. In this article we summarize the Analysis by Synthesis (AbS) approach for deformation tracking in depth and color video and show some successful applications of specialized deformation functions. To overcome the issues with NURBS based deformation tracking we propose a new geodesic RBF-based deformation model, which can adapt to any surface topology and shape, while keeping the number of deformation parameters low. Example deformations for objects of different topologies are given, showing the versatility and efficiency of the proposed model.

  19. The evolution of resistance through costly acquired immunity.

    PubMed Central

    Boots, Michael; Bowers, Roger G.

    2004-01-01

    We examine the evolutionary dynamics of resistance to parasites through acquired immunity. Resistance can be achieved through the innate mechanisms of avoidance of infection and reduced pathogenicity once infected, through recovery from infection and through remaining immune to infection: acquired immunity. We assume that each of these mechanisms is costly to the host and find that the evolutionary dynamics of innate immunity in hosts that also have acquired immunity are quantitatively the same as in hosts that possess only innate immunity. However, compared with resistance through avoidance or recovery, there is less likely to be polymorphism in the length of acquired immunity within populations. Long-lived organisms that can recover at intermediate rates faced with fast-transmitting pathogens that cause intermediate pathogenicity (mortality of infected individuals) are most likely to evolve long-lived acquired immunity. Our work emphasizes that because whether or not acquired immunity is beneficial depends on the characteristics of the disease, organisms may be selected to only develop acquired immunity to some of the diseases that they encounter. PMID:15209105

  20. Weak associativity and deformation quantization

    NASA Astrophysics Data System (ADS)

    Kupriyanov, V. G.

    2016-09-01

    Non-commutativity and non-associativity are quite natural in string theory. For open strings it appears due to the presence of non-vanishing background two-form in the world volume of Dirichlet brane, while in closed string theory the flux compactifications with non-vanishing three-form also lead to non-geometric backgrounds. In this paper, working in the framework of deformation quantization, we study the violation of associativity imposing the condition that the associator of three elements should vanish whenever each two of them are equal. The corresponding star products are called alternative and satisfy important for physical applications properties like the Moufang identities, alternative identities, Artin's theorem, etc. The condition of alternativity is invariant under the gauge transformations, just like it happens in the associative case. The price to pay is the restriction on the non-associative algebra which can be represented by the alternative star product, it should satisfy the Malcev identity. The example of nontrivial Malcev algebra is the algebra of imaginary octonions. For this case we construct an explicit expression of the non-associative and alternative star product. We also discuss the quantization of Malcev-Poisson algebras of general form, study its properties and provide the lower order expression for the alternative star product. To conclude we define the integration on the algebra of the alternative star products and show that the integrated associator vanishes.

  1. Deformity in the "Boxing Boys".

    PubMed

    Ferrence, Susan; Bendersky, Gordon

    2005-01-01

    The late Bronze Age wall painting the Boxing Boys (c. 17th-16th century BCE) was excavated in the ancient town of Akrotiri on the Greek island of Thera. This article considers a medical interpretation for the spinal-pelvic anomaly in the anatomy of one of the boys. The artist has depicted a combination of structural anatomical adjustments diagnostic of spondylolisthesis, a forward slippage of one of the lumbar vertebrae. The accurate portrayal of the surface appearance of this condition suggests that the artist painted directly from a live subject. Thus, the Boxing Boys mural may be the earliest visual record of a sports-induced injury. Although the meaning of the wall paintings is unclear, the wild goats (agrimia) on the adjoining walls simulate swayback as a reflection of the boy's torso deformity and share other features with the boxers, adding to the unifying characteristics of the room. The abnormal morphology appears to be the earliest achievement of transforming disease into aesthetic charm on a monumental scale.

  2. Mathematical textbook of deformable neuroanatomies.

    PubMed

    Miller, M I; Christensen, G E; Amit, Y; Grenander, U

    1993-12-15

    Mathematical techniques are presented for the transformation of digital anatomical textbooks from the ideal to the individual, allowing for the representation of the variabilities manifest in normal human anatomies. The ideal textbook is constructed on a fixed coordinate system to contain all of the information currently available about the physical properties of neuroanatomies. This information is obtained via sensor probes such as magnetic resonance, as well as computed axial and emission tomography, along with symbolic information such as white- and gray-matter tracts, nuclei, etc. Human variability associated with individuals is accommodated by defining probabilistic transformations on the textbook coordinate system, the transformations forming mathematical translation groups of high dimension. The ideal is applied to the individual patient by finding the transformation which is consistent with physical properties of deformable elastic solids and which brings the coordinate system of the textbook to that of the patient. Registration, segmentation, and fusion all result automatically because the textbook carries symbolic values as well as multisensor features.

  3. Mathematical textbook of deformable neuroanatomies.

    PubMed Central

    Miller, M I; Christensen, G E; Amit, Y; Grenander, U

    1993-01-01

    Mathematical techniques are presented for the transformation of digital anatomical textbooks from the ideal to the individual, allowing for the representation of the variabilities manifest in normal human anatomies. The ideal textbook is constructed on a fixed coordinate system to contain all of the information currently available about the physical properties of neuroanatomies. This information is obtained via sensor probes such as magnetic resonance, as well as computed axial and emission tomography, along with symbolic information such as white- and gray-matter tracts, nuclei, etc. Human variability associated with individuals is accommodated by defining probabilistic transformations on the textbook coordinate system, the transformations forming mathematical translation groups of high dimension. The ideal is applied to the individual patient by finding the transformation which is consistent with physical properties of deformable elastic solids and which brings the coordinate system of the textbook to that of the patient. Registration, segmentation, and fusion all result automatically because the textbook carries symbolic values as well as multisensor features. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 Fig. 7 PMID:8265653

  4. Crustal deformation: Earth vs Venus

    NASA Technical Reports Server (NTRS)

    Turcotte, D. L.

    1989-01-01

    It is timely to consider the possible tectonic regimes on Venus both in terms of what is known about Venus and in terms of deformation mechanisms operative on the earth. Plate tectonic phenomena dominate tectonics on the earth. Horizontal displacements are associated with the creation of new crust at ridges and destruction of crust at trenches. The presence of plate tectonics on Venus is debated, but there is certainly no evidence for the trenches associated with subduction on the earth. An essential question is what kind of tectonics can be expected if there is no plate tectonics on Venus. Mars and the Moon are reference examples. Volcanic constructs appear to play a dominant role on Mars but their role on Venus is not clear. On single plate planets and satellites, tectonic structures are often associated with thermal stresses. Cooling of a planet leads to thermal contraction and surface compressive features. Delamination has been propsed for Venus by several authors. Delamination is associated with the subduction of the mantle lithosphere and possibly the lower crust but not the upper crust. The surface manifestations of delamination are unclear. There is some evidence that delamination is occurring beneath the Transverse Ranges in California. Delamination will certainly lead to lithospheric thinning and is likely to lead to uplift and crustal thinning.

  5. Allopurinol in the treatment of acquired reactive perforating collagenosis*

    PubMed Central

    Tilz, Hemma; Becker, Jürgen Christian; Legat, Franz; Schettini, Antonio Pedro Mendes; Inzinger, Martin; Massone, Cesare

    2013-01-01

    Acquired reactive perforating collagenosis is a perforating dermatosis usually associated with different systemic diseases, mainly diabetes mellitus and/or chronic renal insufficiency. Different therapies have been tried but treatment is not standardized yet and remains a challenge. In the last few years, allopurinol has been reported as a good therapeutic option for acquired reactive perforating collagenosis. We describe the case of a 73-year-old man affected by acquired reactive perforating collagenosis associated with diabetes type 1 and chronic renal failure with secondary hyperparathyroidism. The patient was successfully treated with allopurinol 100mg once/day p.o.. PMID:23539010

  6. Acquired epidermodysplasia verruciformis in an HIV-positive patient.

    PubMed

    Lau, Carmen; Acharya, Sashi; Arumainayagam, Joseph T; Kasparis, Christos; Dhesi, I

    2016-10-01

    Epidermodysplasia verruciformis (EV) is a rare dermatological manifestation of the human papillomavirus (HPV) infection, which causes distinctive skin lesions in sun-exposed areas. Both inherited and acquired forms exist. Immunocompromised individuals, such as HIV patients, are at risk of acquired EV. EV poses challenges in its management and variable responses are seen in different individuals. In addition, EV carries a significant risk of skin malignancy with certain HPV types that require skin surveillance. A case of acquired EV in a HIV-positive patient is presented in this report.

  7. Successful steroid treatment of acquired idiopathic partial hypohidrosis.

    PubMed

    Yoritaka, Asako; Hishima, Tsunekazu; Akagi, Kumiko; Kishida, Shuji

    2006-04-01

    The pathogenesis of idiopathic-acquired hypohidrosis remains unknown, and no specific causes have yet been established. We report a 34-year-old man with acquired idiopathic hypohidrosis successfully treated with prednisolone. The patient noticed heat intolerance and hypohidrosis of the pectoral and back during the summer. No systemic disease or neurological findings were identified. Eccrine sweat glands displayed infiltration by inflammatory cells, with immunoglobulin G and C3 deposition in the basement membrane. Steroid therapy improved the hypohidrosis. An immunological pathogenesis could be a major factor in idiopathic-acquired hypohidrosis.

  8. The electrodiagnostic distinctions between chronic familial and acquired demyelinative neuropathies.

    PubMed

    Lewis, R A; Sumner, A J

    1982-06-01

    We compared the electrodiagnostic studies of 40 patients with chronic acquired demyelinative neuropathy and 18 patients with familial demyelinative neuropathy. Patients with acquired neuropathy had differential slowing of conduction velocity when distal latencies were compared with more proximal conduction velocities in the same nerve, when equivalent segments of different nerves were compared, and when dispersion of compound motor action potentials was examined. Conduction block was noted in some patients. Patients with familial disease had uniform conduction slowly of all nerve segments, and conduction block was not seen. Chronic acquired demyelinative neuropathy is characterized by multifocal slowing of nerve conduction, whereas familial demyelinative neuropathy is characterized by uniform conduction slowing.

  9. Motion of deformable ring made of IPMC

    NASA Astrophysics Data System (ADS)

    Firouzeh, Amir; Alasty, Aria; Ozmaeian, Masoumeh

    2012-04-01

    In this paper application of Ionic Polymer Metal Composite (IPMC) as actuator in a deformable ring capable of locomotion is studied. Such a deformable ring moves as a result of gravitational force acting on its body when its shape changes. It can be used in exploration, search and rescue missions in future, where using conventional robots with rigid bodies and actuators is impossible. Large deformation induced by small stimulating voltage, low stiffness the sensing characteristics that in future work can be used in feedback control make IPMC a good choice for such an application. In this work first a model for IPMC is introduce that can be used in simulating deformation of IPMC in different arrangements of actuators. Since in this research we used our own fabricated IPMC, next we present characterization tests and identification results for model's parameters. Then using this model in simulation possibility of generating locomotion using body deformation in a ring made of IPMC is confirmed. Finally result of experiment on deformable ring is presented and possibility of implementation of the proposed design is confirmed. Based on this work, more accurate models can be developed to get better compatibility between experiment and simulation results. Also by modifying fabrication techniques, a deformable ring with faster and steadier movement can be made in future.

  10. Motion of deformable ring made of IPMC

    NASA Astrophysics Data System (ADS)

    Firouzeh, Amir; Alasty, Aria; Ozmaeian, Masoumeh

    2011-11-01

    In this paper application of Ionic Polymer Metal Composite (IPMC) as actuator in a deformable ring capable of locomotion is studied. Such a deformable ring moves as a result of gravitational force acting on its body when its shape changes. It can be used in exploration, search and rescue missions in future, where using conventional robots with rigid bodies and actuators is impossible. Large deformation induced by small stimulating voltage, low stiffness the sensing characteristics that in future work can be used in feedback control make IPMC a good choice for such an application. In this work first a model for IPMC is introduce that can be used in simulating deformation of IPMC in different arrangements of actuators. Since in this research we used our own fabricated IPMC, next we present characterization tests and identification results for model's parameters. Then using this model in simulation possibility of generating locomotion using body deformation in a ring made of IPMC is confirmed. Finally result of experiment on deformable ring is presented and possibility of implementation of the proposed design is confirmed. Based on this work, more accurate models can be developed to get better compatibility between experiment and simulation results. Also by modifying fabrication techniques, a deformable ring with faster and steadier movement can be made in future.

  11. Craniofacial neurofibromatosis: treatment of the midface deformity.

    PubMed

    Singhal, Dhruv; Chen, Yi-Chieh; Tsai, Yueh-Ju; Yu, Chung-Chih; Chen, Hung Chang; Chen, Yu-Ray; Chen, Philip Kuo-Ting

    2014-07-01

    Craniofacial Neurofibromatosis is a benign but devastating disease. While the most common location of facial involvement is the orbito-temporal region, patients often present with significant mid-face deformities. We reviewed our experience with Craniofacial Neurofibromatosis from June 1981 to June 2011 and included patients with midface soft tissue deformities defined as gross alteration of nasal or upper lip symmetry. Data reviewed included the medical records and photobank. Over 30 years, 52 patients presented to and underwent surgical management for Craniofacial Neurofibromatosis at the Chang Gung Craniofacial Center. 23 patients (43%) demonstrated gross mid-facial deformities at initial evaluation. 55% of patients with lip deformities and 28% of patients with nasal deformities demonstrated no direct tumour involvement. The respective deformity was solely due to secondary gravitational effects from neurofibromas of the cheek subunit. Primary tumour infiltration of the nasal and/or labial subunits was treated with excision followed by various methods of reconstruction including lower lateral cartilage repositioning, forehead flaps, free flaps, and/or oral commissure suspension. Soft tissue deformities of the midface are very common in patients with Craniofacial Neurofibromatosis and profoundly affect overall aesthetic outcomes. Distinguishing primary from secondary involvement of the midface assists in surgical decision making.

  12. State-variable theories for nonelastic deformation

    SciTech Connect

    Li, C.Y.

    1981-01-01

    The various concepts of mechanical equation of state for nonelastic deformation in crystalline solids, originally proposed for plastic deformation, have been recently extended to describe additional phenomena such as anelastic and microplastic deformation including the Bauschinger effect. It has been demonstrated that it is possible to predict, based on current state variables in a unified way, the mechanical response of a material under an arbitrary loading. Thus, if the evolution laws of the state variables are known, one can describe the behavior of a material for a thermal-mechanical path of interest, for example, during constant load (or stress) creep without relying on specialized theories. Some of the existing theories of mechanical equation of state for nonelastic deformation are reviewed. The establishment of useful forms of mechanical equation of state has to depend on extensive experimentation in the same way as that involved in the development, for example, the ideal gas law. Recent experimental efforts are also reviewed. It has been possible to develop state-variable deformation models based on experimental findings and apply them to creep, cyclic deformation, and other time-dependent deformation. Attempts are being made to correlate the material parameters of the state-variable models with the microstructure of a material. 24 figures.

  13. Simple shear deformation of partially molten aplite

    NASA Astrophysics Data System (ADS)

    Stipp, Michael; Tullis, Jan; Berger, Alfons

    2013-04-01

    The tectonic processes which are important for melt distribution and transport in the intermediate and lower crust and which can result in crustal weakening are not yet well understood. Natural migmatites are usually overprinted by annealing and retrogression during uplift and exhumation, largely obliterating the deformation structures and microstructures of their partially molten history. Deformation experiments on partially molten crustal rocks have so far been conducted in pure shear geometry and mostly under low confining pressures in the brittle deformation field, both of which are not representative of nature. We carried out deformation experiments in simple shear that predominates in the crust and especially crustal shear zones. Undrained experiments were carried out on Enfield aplite at ~1.5 GPa, 900° -1000° C, and ˜ 5*10-6 s-1, conditions which favor crystal plastic deformation of quartz and feldspar (Dell'Angelo and Tullis, 1988). Sample slices 1.0-1.5 mm thick were placed between the shear pistons with the shear plane at a 45° -angle to the compression direction. Maximum shear strain in the experiments is ? ?2.8. Despite difficulties in controlling the melt content by varying the amount of added water, we were able to achieve the full range of brittle to crystal plastic deformation mechanisms. With decreasing melt content Enfield aplite displays a transition from discrete fracturing at a high angle (~70-90° ) to the shear plane (>20 vol.% melt), to cataclastic shearing (10-20 vol.% melt) and to crystal plastic deformation (

  14. Ultrasound evaluation of foot deformities in infants.

    PubMed

    Miron, Marie-Claude; Grimard, Guy

    2016-02-01

    Foot deformity in infants is the most common congenital musculoskeletal condition. A precise diagnosis can sometimes be impossible to establish clinically. Radiologic imaging plays a major role in the evaluation of musculoskeletal abnormalities. However conventional imaging techniques, such as plain radiographs of the foot, are of very little help in this age group because of the lack of ossification of the tarsal bones. US presents a significant advantage because it permits the visualization of cartilaginous structures. This leads to the detailed assessment of foot deformities in infants. Furthermore, US can also be used as a dynamic imaging modality. Different scanning views are beneficial to evaluate the complete anatomy of the foot; depending on the suspected clinical diagnosis, some planes are more informative to display the pathological features of a specific deformity. We describe the US findings of five of the most common foot deformities referred to our pediatric orthopedic clinic (clubfoot, simple metatarsus adductus, skewfoot, and oblique and vertical talus). For each deformity we propose a specific imaging protocol based on US to provide an accurate diagnosis. US is a complementary tool to the clinical examination for determining the diagnosis and the severity of the deformity and also for monitoring the efficacy of treatment. Radiologists investigating foot deformities in infants should consider using US for the detailed assessment of the foot in this age group.

  15. Volume and tissue composition preserving deformation of breast CT images to simulate breast compression in mammographic imaging

    NASA Astrophysics Data System (ADS)

    Han, Tao; Chen, Lingyun; Lai, Chao-Jen; Liu, Xinming; Shen, Youtao; Zhong, Yuncheng; Ge, Shuaiping; Yi, Ying; Wang, Tianpeng; Shaw, Chris C.

    2009-02-01

    Images of mastectomy breast specimens have been acquired with a bench top experimental Cone beam CT (CBCT) system. The resulting images have been segmented to model an uncompressed breast for simulation of various CBCT techniques. To further simulate conventional or tomosynthesis mammographic imaging for comparison with the CBCT technique, a deformation technique was developed to convert the CT data for an uncompressed breast to a compressed breast without altering the breast volume or regional breast density. With this technique, 3D breast deformation is separated into two 2D deformations in coronal and axial views. To preserve the total breast volume and regional tissue composition, each 2D deformation step was achieved by altering the square pixels into rectangular ones with the pixel areas unchanged and resampling with the original square pixels using bilinear interpolation. The compression was modeled by first stretching the breast in the superior-inferior direction in the coronal view. The image data were first deformed by distorting the voxels with a uniform distortion ratio. These deformed data were then deformed again using distortion ratios varying with the breast thickness and re-sampled. The deformation procedures were applied in the axial view to stretch the breast in the chest wall to nipple direction while shrinking it in the mediolateral to lateral direction re-sampled and converted into data for uniform cubic voxels. Threshold segmentation was applied to the final deformed image data to obtain the 3D compressed breast model. Our results show that the original segmented CBCT image data were successfully converted into those for a compressed breast with the same volume and regional density preserved. Using this compressed breast model, conventional and tomosynthesis mammograms were simulated for comparison with CBCT.

  16. Development of Multiorgan Finite Element-Based Prostate Deformation Model Enabling Registration of Endorectal Coil Magnetic Resonance Imaging for Radiotherapy Planning

    SciTech Connect

    Hensel, Jennifer M.; Menard, Cynthia; Chung, Peter W.M.; Milosevic, Michael F.; Kirilova, Anna; Moseley, Joanne L.; Haider, Masoom A.; Brock, Kristy K. . E-mail: kristy.brock@rmp.uhn.on.ca

    2007-08-01

    Purpose: Endorectal coil (ERC) magnetic resonance imaging (MRI) provides superior visualization of the prostate compared with computed tomography at the expense of deformation. This study aimed to develop a multiorgan finite element deformable method, Morfeus, to accurately co-register these images for radiotherapy planning. Methods: Patients with prostate cancer underwent fiducial marker implantation and computed tomography simulation for radiotherapy planning. A series of axial MRI scans were acquired with and without an ERC. The prostate, bladder, rectum, and pubic bones were manually segmented and assigned linear elastic material properties. Morfeus mapped the surface of the bladder and rectum between two imaged states, calculating the deformation of the prostate through biomechanical properties. The accuracy of deformation was measured as fiducial marker error and residual surface deformation between the inferred and actual prostate. The deformation map was inverted to deform from 100 cm{sup 3} to no coil. Results: The data from 19 patients were analyzed. Significant prostate deformation occurred with the ERC (mean intrapatient range, 0.88 {+-} 0.25 cm). The mean vector error in fiducial marker position (n = 57) was 0.22 {+-} 0.09 cm, and the mean vector residual surface deformation (n = 19) was 0.15 {+-} 0.06 cm for deformation from no coil to 100-cm{sup 3} ERC, with an image vector resolution of 0.22 cm. Accurately deformed MRI scans improved soft-tissue resolution of the anatomy for radiotherapy planning. Conclusions: This method of multiorgan deformable registration enabled accurate co-registration of ERC-MRI scans with computed tomography treatment planning images. Superior structural detail was visible on ERC-MRI, which has potential for improving target delineation.

  17. Isothermal deformation of gamma titanium aluminide

    SciTech Connect

    Srinivasan, R.; Singh, J.P.; Tuval, E.; Weiss, I.

    1996-04-15

    Gamma titanium aluminide has received considerable attention in recent years from the automotive industry as a potential material for making rotating and reciprocating components to produce a quieter and more efficient engine. The objectives of this study were to identify processing routes for the manufacture of automobile valves from gamma titanium aluminide. The issues considered were microstructure and composition of the material, and processing parameters such as deformation rates, temperatures, and total deformation. This paper examines isothermal deformation of gamma titanium aluminide in order to develop a processing window for this type of material.

  18. Cubic Wavefunction Deformation of Compressed Atoms

    NASA Astrophysics Data System (ADS)

    Portela, Pedro Calvo; Llanes-Estrada, Felipe J.

    2015-05-01

    We hypothesize that in a non-metallic crystalline structure under extreme pressures, atomic wavefunctions deform to adopt a reduced rotational symmetry consistent with minimizing interstitial space in the crystal. We exemplify with a simple numeric variational calculation that yields the energy cost of this deformation for Helium to 25 %. Balancing this with the free energy gained by tighter packing we obtain the pressures required to effect such deformation. The consequent modification of the structure suggests a decrease in the resistance to tangential stress, and an associated decrease of the crystal's shear modulus. The atomic form factor is also modified. We also compare with neutron matter in the interior of compact stars.

  19. Mounting with compliant cylinders for deformable mirrors.

    PubMed

    Reinlein, Claudia; Goy, Matthias; Lange, Nicolas; Appelfelder, Michael

    2015-04-01

    A method is presented to mount large aperture unimorph deformable mirrors by compliant cylinders (CC). The CCs are manufactured from a soft silicone, and shear testing is performed in order to evaluate the Young's modulus. A scale mirror model is assembled to evaluate mount-induced change of piezoelectric deformation, and its applicability for tightly focusing mirrors. Experiments do not show any decrease of piezoelectric stroke. Further it is shown that the changes of surface fidelity by the attachment of the deformable mirror to its mount are neglectable.

  20. Liquid Droplets on a Highly Deformable Membrane

    NASA Astrophysics Data System (ADS)

    Schulman, Rafael; Dalnoki-Veress, Kari

    2015-11-01

    We present measurements of the deformation produced by micro-droplets atop thin elastomeric and glassy free-standing films. Due to the Laplace pressure, the droplets deform the elastic membrane thereby forming a bulge. Thus, there are two angles that define the droplet/membrane geometry: the angle the liquid surface makes with the film and the angle the deformed bulge makes with the film. The contact line geometry is well captured by a Neumann construction which includes contributions from interfacial and mechanical tensions. Finally, we show that a droplet atop a film with biaxial tension assumes an equilibrium shape which is elongated along the axis of high tension.

  1. Dynamic grain growth during superplastic deformation

    SciTech Connect

    Rabinovich, M.Kh.; Trifonov, V.G.

    1996-05-01

    Superplastic deformation (SPD) causes the accelerated anisotropic grain growth. This process results in the formation of structure which is quasistable during superplastic deformation and unstable after deformation. The degree of instability is determined by the size of grains, their shape coefficient which depends on the nature of an alloy and is equal to 1.1--1.5 after SPD, and by the unbalance of triple junctions at boundaries. Alloying of metals can affect the thermodynamic force and mechanism of dynamic anisotropic grain growth and correspondingly influence the parameters of superplasticity in alloys.

  2. Atomistic deformation mechanisms in twinned copper nanospheres.

    PubMed

    Bian, Jianjun; Niu, Xinrui; Zhang, Hao; Wang, Gangfeng

    2014-01-01

    In the present study, we perform molecular dynamic simulations to investigate the compression response and atomistic deformation mechanisms of twinned nanospheres. The relationship between load and compression depth is calculated for various twin spacing and loading directions. Then, the overall elastic properties and the underlying plastic deformation mechanisms are illuminated. Twin boundaries (TBs) act as obstacles to dislocation motion and lead to strengthening. As the loading direction varies, the plastic deformation transfers from dislocations intersecting with TBs, slipping parallel to TBs, and then to being restrained by TBs. The strengthening of TBs depends strongly on the twin spacing.

  3. Deformation mechanisms of plasticized starch materials.

    PubMed

    Mikus, P-Y; Alix, S; Soulestin, J; Lacrampe, M F; Krawczak, P; Coqueret, X; Dole, P

    2014-12-19

    The aim of this paper is to understand the influence of plasticizer and plasticizer amount on the mechanical and deformation behaviors of plasticized starch. Glycerol, sorbitol and mannitol have been used as plasticizers. After extrusion of the various samples, dynamic mechanical analyses and video-controlled tensile tests have been performed. It was found that the nature of plasticizer, its amount as well as the aging of the material has an impact on the involved deformation mechanism. The variations of volume deformation could be explained by an antiplasticization effect (low plasticizer amount), a phase-separation phenomenon (excess of plasticizer) and/or by the retrogradation of starch.

  4. Chiari type 1 malformation in an infant with type 2 Pfeiffer syndrome: further evidence of acquired pathogenesis.

    PubMed

    Ranger, Adrianna; Al-Hayek, Ali; Matic, Damir

    2010-03-01

    There seems to be an association between type 1 Chiari malformation (CM) and some congenital craniosynostosis syndromes. Type 2 Pfeiffer syndrome is a condition associated with premature fusion of multiple cranial sutures, cloverleaf skull (kleeblatschädel deformity), prominent ptosis, thumb and first toe abnormalities, variable syndactyly, and mutated genes for type 1 or 2 fibroblast growth factor receptor. These children generally do poorly because of significant often severe neurologic and cognitive defects, and many die very young. Roughly half of all patients with Pfeiffer syndrome, and virtually all with type 2 disease, also have type 1 CM. Chiari malformation may not be congenital but acquired as a consequence of the skull deformities and other associated intracranial factors in patients with craniosynostosis. We report a term male infant with type 2 Pfeiffer syndrome, who was not noted to have any CM on initial brain imaging done at 2 months but in whom repeated imaging demonstrated clear evidence of CM by 4 months, despite reconstructive craniotomies and unilateral ventriculoperitoneal shunt insertion. Posterior fossa decompression yielded a good result. This patient provides further evidence to support the concept of acquired tonsillar herniation in patients with craniosynostosis syndromes. The etiology seems multifactorial and related to (1) the disproportionately slow growth of the skull relative to the brain, particularly in the posterior fossa, secondary to early fusion of skull sutures, in turn secondary to congenital deficiencies in fibroblast growth factor receptors; (2) impaired venous sinus drainage; (3) hydrocephalus; and (4) resultant elevations in intracranial pressure.

  5. A Comparison of Deformed Wing Virus in Deformed and Asymptomatic Honey Bees

    PubMed Central

    Brettell, Laura E.; Mordecai, Gideon J.; Schroeder, Declan C.; Jones, Ian M.; da Silva, Jessica R.; Vicente-Rubiano, Marina; Martin, Stephen J.

    2017-01-01

    Deformed wing virus (DWV) in association with Varroa destructor is currently attributed to being responsible for colony collapse in the western honey bee (Apis mellifera). The appearance of deformed individuals within an infested colony has long been associated with colony losses. However, it is unknown why only a fraction of DWV positive bees develop deformed wings. This study concerns two small studies comparing deformed and non-deformed bees. In Brazil, asymptomatic bees (no wing deformity) that had been parasitised by Varroa as pupae had higher DWV loads than non-parasitised bees. However, we found no greater bilateral asymmetry in wing morphology due to DWV titres or parasitisation. As expected, using RT-qPCR, deformed bees were found to contain the highest viral loads. In a separate study, next generation sequencing (NGS) was applied to compare the entire DWV genomes from paired symptomatic and asymptomatic bees from three colonies on two different Hawaiian islands. This revealed no consistent differences between DWV genomes from deformed or asymptomatic bees, with the greatest variation seen between locations, not phenotypes. All samples, except one, were dominated by DWV type A. This small-scale study suggests that there is no unique genetic variant associated with wing deformity; but that many DWV variants have the potential to cause deformity. PMID:28272333

  6. A Comparison of Deformed Wing Virus in Deformed and Asymptomatic Honey Bees.

    PubMed

    Brettell, Laura E; Mordecai, Gideon J; Schroeder, Declan C; Jones, Ian M; da Silva, Jessica R; Vicente-Rubiano, Marina; Martin, Stephen J

    2017-03-07

    Deformed wing virus (DWV) in association with Varroa destructor is currently attributed to being responsible for colony collapse in the western honey bee (Apis mellifera). The appearance of deformed individuals within an infested colony has long been associated with colony losses. However, it is unknown why only a fraction of DWV positive bees develop deformed wings. This study concerns two small studies comparing deformed and non-deformed bees. In Brazil, asymptomatic bees (no wing deformity) that had been parasitised by Varroa as pupae had higher DWV loads than non-parasitised bees. However, we found no greater bilateral asymmetry in wing morphology due to DWV titres or parasitisation. As expected, using RT-qPCR, deformed bees were found to contain the highest viral loads. In a separate study, next generation sequencing (NGS) was applied to compare the entire DWV genomes from paired symptomatic and asymptomatic bees from three colonies on two different Hawaiian islands. This revealed no consistent differences between DWV genomes from deformed or asymptomatic bees, with the greatest variation seen between locations, not phenotypes. All samples, except one, were dominated by DWV type A. This small-scale study suggests that there is no unique genetic variant associated with wing deformity; but that many DWV variants have the potential to cause deformity.

  7. Management of bleeding in acquired hemophilia A: results from the European Acquired Haemophilia (EACH2) Registry.

    PubMed

    Baudo, Francesco; Collins, Peter; Huth-Kühne, Angela; Lévesque, Hervé; Marco, Pascual; Nemes, László; Pellegrini, Fabio; Tengborn, Lilian; Knoebl, Paul

    2012-07-05

    Acquired hemophilia A is a rare bleeding disorder caused by autoantibodies to coagulation FVIII. Bleeding episodes at presentation are spontaneous and severe in most cases. Optimal hemostatic therapy is controversial, and available data are from observational and retrospective studies only. The EACH2 registry, a multicenter, pan-European, Web-based database, reports current patient management. The aim was to assess the control of first bleeding episodes treated with a bypassing agent (rFVIIa or aPCC), FVIII, or DDAVP among 501 registered patients. Of 482 patients with one or more bleeding episodes, 144 (30%) received no treatment for bleeding; 31 were treated with symptomatic therapy only. Among 307 patients treated with a first-line hemostatic agent, 174 (56.7%) received rFVIIa, 63 (20.5%) aPCC, 56 (18.2%) FVIII, and 14 (4.6%) DDAVP. Bleeding was controlled in 269 of 338 (79.6%) patients treated with a first-line hemostatic agent or ancillary therapy alone. Propensity score matching was applied to allow unbiased comparison between treatment groups. Bleeding control was significantly higher in patients treated with bypassing agents versus FVIII/DDAVP (93.3% vs 68.3%; P = .003). Bleeding control was similar between rFVIIa and aPCC (93.0%; P = 1). Thrombotic events were reported in 3.6% of treated patients with a similar incidence between rFVIIa (2.9%) and aPCC (4.8%).

  8. Immunosuppression for acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2).

    PubMed

    Collins, Peter; Baudo, Francesco; Knoebl, Paul; Lévesque, Hervé; Nemes, László; Pellegrini, Fabio; Marco, Pascual; Tengborn, Lilian; Huth-Kühne, Angela

    2012-07-05

    Acquired hemophilia A (AHA) is an autoimmune disease caused by an autoantibody to factor VIII. Patients are at risk of severe and fatal hemorrhage until the inhibitor is eradicated, and guidelines recommend immunosuppression as soon as the diagnosis has been made. The optimal immunosuppressive regimen is unclear; therefore, data from 331 patients entered into the prospective EACH2 registry were analyzed. Steroids combined with cyclophosphamide resulted in more stable complete remission (70%), defined as inhibitor undetectable, factor VIII more than 70 IU/dL and immunosuppression stopped, than steroids alone (48%) or rituximab-based regimens (59%). Propensity score-matched analysis controlling for age, sex, factor VIII level, inhibitor titer, and underlying etiology confirmed that stable remission was more likely with steroids and cyclophosphamide than steroids alone (odds ratio = 3.25; 95% CI, 1.51-6.96; P < .003). The median time to complete remission was approximately 5 weeks for steroids with or without cyclophosphamide; rituximab-based regimens required approximately twice as long. Immunoglobulin administration did not improve outcome. Second-line therapy was successful in approximately 60% of cases that failed first-line therapy. Outcome was not affected by the choice of first-line therapy. The likelihood of achieving stable remission was not affected by underlying etiology but was influenced by the presenting inhibitor titer and FVIII level.

  9. Surgical salvage of acquired lung lesions in extremely premature infants.

    PubMed

    Sacks, Greg D; Chung, Katherine; Jamil, Kevin; Garg, Meena; Dunn, James C Y; DeUgarte, Daniel A

    2014-05-01

    Acquired neonatal lung lesions including pneumatoceles, cystic bronchopulmonary dysplasia, and pulmonary interstitial emphysema can cause extrinsic mediastinal compression, which may impair pulmonary and cardiac function. Acquired lung lesions are typically managed medically. Here we report a case series of three extremely premature infants with acquired lung lesions. All three patients underwent aggressive medical management and ultimately required tube thoracostomies. These interventions were unsuccessful and emergency thoracotomies were performed in each case. Two infants with acquired pneumatoceles underwent unroofing of the cystic structure and primary repair of a bronchial defect. The third infant with pulmonary interstitial emphysema, arising from cystic bronchopulmonary dysplasia, required a middle lobectomy for severe and diffuse cystic disease. When medical management fails, tube thoracostomy can be attempted, leaving surgical intervention for refractory cases. Surgical options include oversewing a bronchial defect in the setting of a bronchopleural fistula or lung resection in cases of an isolated expanding lobe.

  10. Acquired pericentric inversion of chromosome 9 in acute myeloid leukemia.

    PubMed

    Udayakumar, A M; Pathare, A V; Dennison, D; Raeburn, J A

    2009-01-01

    Pericentric inversion of chromosome 9 involving the qh region is relatively common as a constitutional genetic aberration without any apparent phenotypic consequences. However, it has not been established as an acquired abnormality in cancer. Among the three patients reported so far in the literature with acquired inv(9), only one had acute myeloid leukemia (AML). Here we describe an unique case where both chromosomes 9 presented with an acquired pericentric inversion with breakpoints at 9p13 and 9q12 respectively, in a AML patient with aberrant CD7 and CD9 positivity. Additionally, one der(9) also showed short arm deletion at 9p21 to the centromeric region and including the p16 gene. The constitutional karyotype was normal. This is probably the first report describing an acquired inv(9) involving both chromosomes 9 in AML. The possible significance of this inversion is discussed.

  11. Acquired localised hypertrichosis in a Chinese child after cast immobilisation.

    PubMed

    Yuen, M W; Lai, Loretta K P; Chan, P F; Chao, David V K

    2015-08-01

    Hypertrichosis refers to excessive hair growth that is independent of any androgen effect. Hypertrichosis could be congenital or acquired, localised or generalised. The phenomenon of acquired localised hypertrichosis following cast application for a fracture is well known to orthopaedic surgeons, but is rarely encountered by primary care physicians. We describe a 28-month-old Chinese boy who had fracture of right leg as a result of an injury. He had a cast applied by an orthopaedic surgeon as treatment. On removal of the cast 6 weeks later, he was noticed to have significant hair growth on his right leg compared with the left leg. The patient was reassessed 3 months after removal of the cast. The hypertrichosis resolved completely with time. This patient was one of the youngest among the reported cases of acquired localised hypertrichosis after cast application. We illustrate the significance of management of post-cast-acquired localised hypertrichosis in the primary care setting.

  12. Metastatic thymoma and acquired generalized myasthenia gravis in a beagle.

    PubMed

    Moffet, Adrienne C

    2007-01-01

    A 16-year-old, spayed female beagle was diagnosed with metastatic thymoma causing a probable paraneoplastic syndrome of generalized acquired myasthenia gravis. Anticholinesterase treatment was initiated; however, 5 days later the dog died.

  13. Deformation Behavior of Nanoporous Metals

    SciTech Connect

    Biener, J; Hodge, A M; Hamza, A V

    2007-11-28

    of free surfaces can no longer be neglected. As the material becomes more and more constraint by the presence of free surfaces, length scale effects on plasticity become more and more important and bulk properties can no longer be used to describe the material properties. Even the elastic properties may be affected as the reduced coordination of surface atoms and the concomitant redistribution of electrons may soften or stiffen the material. If, and to what extend, such length scale effects control the mechanical behavior of nanoporous materials depends strongly on the material and the characteristic length scale associated with its plastic deformation. For example, ductile materials such as metals which deform via dislocation-mediated processes can be expected to exhibit pronounced length scale effects in the sub-micron regime where free surfaces start to constrain efficient dislocation multiplication. In this chapter we will limit our discussion to our own area of expertise which is the mechanical behavior of nanoporous open-cell gold foams as a typical example of nanoporous metal foams. Throughout this chapter we will review our current understanding of the mechanical properties of nanoporous open-cell foams including both experimental and theoretical studies.

  14. Deformable Mirror Materials Issue Assessment

    SciTech Connect

    Rudd, R E

    2008-05-27

    It was a pleasure to speak with you and Dr. Olivier Guyon about your project to develop a coronagraph and in particular about materials science considerations in the development of the deformable mirror (DM) for the coronagraph. The coronagraph application will demand more of a DM than previous applications with regard to precision, and since the characterization and modeling tools are currently under development, you asked me to comment on materials issues that might impact the DM design and testing. I have not conducted research on this question, and my own research on modeling MEMS has not included DM systems. I am only in a position to discuss some general considerations that may help in developing a research plan for the DM system. As I understand it, the relevant points about the DM system are as follows. The DM surface needs to be positioned to less than 1 {angstrom} RMS of the desired shape, and be stable to 0.3 {angstrom} RMS for an hour. In the ultimate application in space the stability requirements may be greater. For example, the DM shape can be set using a bright star and then allow the coronagraph to be turned to a dim star to collect data for several hours, counting on the mirror shape to be stable. The DM is made of a polysilicon membrane coated with one or more metal layers for the reflective surface and actuated by 32x32 or 64x64 electrostatic actuators on the back side. The uncertainty in the position of any one actuator should be at the few-picometer level or less averaged over the 300-{micro}m region of the actuator. Currently, experiments are conducted that can characterize the surface shape to the 1 nm level, and it is anticipated that the experiments will be able to characterize the shape at the sub-Angstrom level but not in the immediate future. Regarding stability, under relatively large deformations (10's of nm), the DM mirror surface shows no hysteresis at the measurable nm level. Let me begin by saying that I am not aware of any

  15. Rocky Mountain spotted fever acquired in Florida, 1973-83.

    PubMed

    Sacks, J J; Janowski, H T

    1985-12-01

    From 1973 to 1983, 49 Florida residents were reported with confirmed Rocky Mountain spotted fever (RMSF), 25 of whom were considered to have had Florida-acquired disease. Although there was no history of tick exposure for six of these 25 persons, all had contact with dogs or outdoor activities during the incubation period. The tick vectors of RMSF are widely distributed throughout Florida. We conclude that RMSF, although rare in Florida, can be acquired in the state.

  16. Orthostatic intolerance in multifocal acquired demyelinating sensory and motor neuropathy.

    PubMed

    Tramontozzi, Louis A; Russell, James A

    2012-09-01

    We report a patient with orthostatic intolerance and syncope as a major clinical manifestation of an acquired multifocal neuropathy with the clinical, electrodiagnostic, and cerebrospinal fluid features of multifocal acquired demyelinating sensory and motor neuropathy or the Lewis-Sumner syndrome. Immunomodulatory therapy led to clinical remission of both somatic and autonomic signs and symptoms. We are unaware of a previous description of symptomatic dysautonomia in this disorder.

  17. Postseismic Deformation from the 1995 Kobe Earthquake Detected with InSAR

    NASA Astrophysics Data System (ADS)

    Hashimoto, M.; Ozawa, T.

    2014-12-01

    About 20 years have passed since the 1995 earthquake of Mw 6.9 hit the Kobe and Awaji areas in Japan. This earthquake was a right lateral faulting on the nearly vertical Rokko fault trending in the NE-SW direction. Coseismic deformations were studied using campaign GPS, leveling and InSAR, but postseismic deformations have not been well investigated. Nakano and Hirahara (1997) and Kato et al. (1997) reported postseismic deformation detected by GPS up to 1996, while Ozawa et al. (2004) presented the results of the analysis of JERS-1 SAR images acquired during 1995 - 1998. We reexamined postseismic deformation from the 1995 Kobe, Japan, earthquake using ERS/Envisat and JERS-1 SAR data. 14 ERS-1/2, 22 Envisat and 7 JERS-1 images acquired during 1992 to 2007 that cover the Kobe and northern Osaka areas were collected and analyzed. We applied 2-pass interferometry. We divided whole period into 5 intervals, preseismic, coseismic and 1995 - 2004 for ERS-1/2, 2003 - 2004 and 2004 - 2007 for Envisat, and stacked interferograms during each period. We found that rapid subsidence in a wedge shaped region near the northeastern tip of the source fault. This wedge shaped area is bounded by two active faults; the Arima-Takatsuki fault on the north side, and the Rokko fault on the other side. This deformation is already pointed out by Ozawa et al. (2004). It is noteworthy that this subsidence is not clear in the preseismic interferogram, which implies the Kobe earthquake may have triggered this subsidence. Considering the shape of subsided region, the configuration of basement structure is closely related to the deformation, while it is difficult to explain any model of simple afterslip or viscoelastic relaxation with the assumption of homogeneous structure. This subsidence decayed slowly and became less clear after 2007 according our previous study using ALOS/PALSAR. Furthermore there are two spots of further rapid subsidence of > 10 mm/yr in this region. These two spots are

  18. Intensive care unit-acquired weakness in the burn population.

    PubMed

    Cubitt, Jonathan J; Davies, Menna; Lye, George; Evans, Janine; Combellack, Tom; Dickson, William; Nguyen, Dai Q

    2016-05-01

    Intensive care unit-acquired weakness is an evolving problem in the burn population. As patients are surviving injuries that previously would have been fatal, the focus of treatment is shifting from survival to long-term outcome. The rehabilitation of burn patients can be challenging; however, a certain subgroup of patients have worse outcomes than others. These patients may suffer from intensive care unit-acquired weakness, and their treatment, physiotherapy and expectations need to be adjusted accordingly. This study investigates the condition of intensive care unit-acquired weakness in our burn centre. We conducted a retrospective analysis of all the admissions to our burn centre between 2008 and 2012 and identified 22 patients who suffered from intensive care unit-acquired weakness. These patients were significantly younger with significantly larger burns than those without intensive care unit-acquired weakness. The known risk factors for intensive care unit-acquired weakness are commonplace in the burn population. The recovery of these patients is significantly affected by their weakness.

  19. Evaluation of model-based deformation correction in image-guided liver surgery via tracked intraoperative ultrasound

    PubMed Central

    Clements, Logan W.; Collins, Jarrod A.; Weis, Jared A.; Simpson, Amber L.; Adams, Lauryn B.; Jarnagin, William R.; Miga, Michael I.

    2016-01-01

    Abstract. Soft-tissue deformation represents a significant error source in current surgical navigation systems used for open hepatic procedures. While numerous algorithms have been proposed to rectify the tissue deformation that is encountered during open liver surgery, clinical validation of the proposed methods has been limited to surface-based metrics, and subsurface validation has largely been performed via phantom experiments. The proposed method involves the analysis of two deformation-correction algorithms for open hepatic image-guided surgery systems via subsurface targets digitized with tracked intraoperative ultrasound (iUS). Intraoperative surface digitizations were acquired via a laser range scanner and an optically tracked stylus for the purposes of computing the physical-to-image space registration and for use in retrospective deformation-correction algorithms. Upon completion of surface digitization, the organ was interrogated with a tracked iUS transducer where the iUS images and corresponding tracked locations were recorded. Mean closest-point distances between the feature contours delineated in the iUS images and corresponding three-dimensional anatomical model generated from preoperative tomograms were computed to quantify the extent to which the deformation-correction algorithms improved registration accuracy. The results for six patients, including eight anatomical targets, indicate that deformation correction can facilitate reduction in target error of ∼52%. PMID:27081664

  20. Measuring Crustal Deformation Caused by the Nepal (Gorkha) Earthquake Using ALOS-2 SAR Interferometry

    NASA Astrophysics Data System (ADS)

    Morishita, Y.; Kobayashi, T.; Yarai, H.

    2015-12-01

    A huge earthquake (Mw 7.8, USGS) occurred on 25 April, 2015 in Nepal, followed by the largest aftershock (Mw 7.3, USGS) on 12 May. We applied an InSAR technique to detect crustal deformation caused by the earthquakes using L-band SAR data acquired by ALOS-2. One of the advantages of ALOS-2 over ALOS is ScanSAR interferometry. Beam synchronization, which is a critical factor for ScanSAR interferometry, is always tuned among ALOS-2 observations. While a width of 350 km is covered by a ScanSAR acquisition, the provided data is divided into five swaths with each width of 70 km. Adjacent swaths have an overlapping area with a width of several kilometers, where interferometric phases for two swaths are basically comparable. We processed each swath independently. Preliminary interferograms are contaminated by noises with long wavelength, which makes it difficult to measure the amount of the crustal deformation accurately. We reduce the noises by following steps. First, pseudo reference points with no displacement are put at intervals of 40-100 km outside of the possible deforming area. The differential phase at the points are assumed to be due to the noises. The curved surface of the noises is estimated by smoothly interpolating the differential phase at the points. Note that the pseudo reference points should be located in a high coherence area where the phases can be unwrapped. Furthermore the points in the overlapping area between adjacent swaths allow to preserve consistency of the phases between adjacent swaths. The interferograms show the clear and detailed crustal deformation (published on http://www.gsi.go.jp/cais/topic150429-index-e.html). The maximum of a quasi up-down component of the deformation estimated from the interferograms with different beam directions reaches over 1.4 m uplift at 20 km northeast from Kathmandu and 0.6 m subsidence at a northern part of the deforming area.

  1. Coseismic Deformation Field and Fault Slip Distribution of the 2015 Chile Mw8.3 Earthquake

    NASA Astrophysics Data System (ADS)

    Qu, Chunyan; Zuo, Ronghu; Shan, Xin Jian; Zhang, Guohong; Zhang, Yingfeng; Song, Xiaogang

    2016-06-01

    On September 16, 2015, a magnitude 8.3 earthquake struck west of Illapel, Chile. We analyzed Sentinel-1A/IW InSAR data on the descending track acquired before and after the Chile Mw8.3 earthquake of 16 September 2015. We found that the coseismic deformation field of this event consists of many semi circular fringes protruding to east in an approximately 300km long and 190km wide region. The maximum coseismic displacement is about 1.33m in LOS direction corresponding to subsidence or westward shift of the ground. We inverted the coseismic fault slip based on a small-dip single plane fault model in a homogeneous elastic half space. The inverted coseismic slip mainly concentrates at shallow depth above the hypocenter with a symmetry shape. The rupture length along strike is about 340 km with maximum slip of about 8.16m near the trench. The estimated moment is 3.126×1021 N.m (Mw8.27) the maximum depth of coseismic slip near zero appears to 50km. We also analyzed the postseismic deformation fields using four interferograms with different time intervals. The results show that postseismic deformation occurred in a narrow area of approximately 65km wide with maximum slip 11cm, and its predominant motion changes from uplift to subsidence with time. that is to say, at first, the postseismic deformation direction is opposite to that of coseismic deformation, then it tends to be consistent with coseismic deformation.It maybe indicates the differences and changes in the velocity between the Nazca oceanic plate and the South American continental plate.

  2. A comparative study of photoinduced deformation in azobenzene containing polymer films.

    PubMed

    Yadavalli, Nataraja Sekhar; Loebner, Sarah; Papke, Thomas; Sava, Elena; Hurduc, Nicolae; Santer, Svetlana

    2016-03-07

    In this paper two groups supporting different views on the mechanism of light induced polymer deformation argue about the respective underlying theoretical conceptions, in order to bring this interesting debate to the attention of the scientific community. The group of Prof. Nicolae Hurduc supports the model claiming that the cyclic isomerization of azobenzenes may cause an athermal transition of the glassy azobenzene containing polymer into a fluid state, the so-called photo-fluidization concept. This concept is quite convenient for an intuitive understanding of the deformation process as an anisotropic flow of the polymer material. The group of Prof. Svetlana Santer supports the re-orientational model where the mass-transport of the polymer material accomplished during polymer deformation is stated to be generated by the light-induced re-orientation of the azobenzene side chains and as a consequence of the polymer backbone that in turn results in local mechanical stress, which is enough to irreversibly deform an azobenzene containing material even in the glassy state. For the debate we chose three polymers differing in the glass transition temperature, 32 °C, 87 °C and 95 °C, representing extreme cases of flexible and rigid materials. Polymer film deformation occurring during irradiation with different interference patterns is recorded using a homemade set-up combining an optical part for the generation of interference patterns and an atomic force microscope for acquiring the kinetics of film deformation. We also demonstrated the unique behaviour of azobenzene containing polymeric films to switch the topography in situ and reversibly by changing the irradiation conditions. We discuss the results of reversible deformation of three polymers induced by irradiation with intensity (IIP) and polarization (PIP) interference patterns, and the light of homogeneous intensity in terms of two approaches: the re-orientational and the photo-fluidization concepts. Both agree

  3. 7 CFR 51.319 - Seriously deformed.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., CERTIFICATION, AND STANDARDS) United States Standards for Grades of Apples Definitions § 51.319 Seriously deformed. “Seriously deformed” means that the apple is so badly misshapen that its appearance is...

  4. 7 CFR 51.319 - Seriously deformed.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., CERTIFICATION, AND STANDARDS) United States Standards for Grades of Apples Definitions § 51.319 Seriously deformed. “Seriously deformed” means that the apple is so badly misshapen that its appearance is...

  5. GEOPHYSICS. Layered deformation in the Taiwan orogen.

    PubMed

    Huang, T-Y; Gung, Y; Kuo, B-Y; Chiao, L-Y; Chen, Y-N

    2015-08-14

    The underthrusting of continental crust during mountain building is an issue of debate for orogens at convergent continental margins. We report three-dimensional seismic anisotropic tomography of Taiwan that shows a nearly 90° rotation of anisotropic fabrics across a 10- to 20-kilometer depth, consistent with the presence of two layers of deformation. The upper crust is dominated by collision-related compressional deformation, whereas the lower crust of Taiwan, mostly the crust of the subducted Eurasian plate, is dominated by convergence-parallel shear deformation. We interpret this lower crustal shearing as driven by the continuous sinking of the Eurasian mantle lithosphere when the surface of the subducted plate is coupled with the orogen. The two-layer deformation clearly defines the role of subduction in the formation of the Taiwan mountain belt.

  6. Probing deformed commutators with macroscopic harmonic oscillators

    PubMed Central

    Bawaj, Mateusz; Biancofiore, Ciro; Bonaldi, Michele; Bonfigli, Federica; Borrielli, Antonio; Di Giuseppe, Giovanni; Marconi, Lorenzo; Marino, Francesco; Natali, Riccardo; Pontin, Antonio; Prodi, Giovanni A.; Serra, Enrico; Vitali, David; Marin, Francesco

    2015-01-01

    A minimal observable length is a common feature of theories that aim to merge quantum physics and gravity. Quantum mechanically, this concept is associated with a nonzero minimal uncertainty in position measurements, which is encoded in deformed commutation relations. In spite of increasing theoretical interest, the subject suffers from the complete lack of dedicated experiments and bounds to the deformation parameters have just been extrapolated from indirect measurements. As recently proposed, low-energy mechanical oscillators could allow to reveal the effect of a modified commutator. Here we analyze the free evolution of high-quality factor micro- and nano-oscillators, spanning a wide range of masses around the Planck mass mP (≈22 μg). The direct check against a model of deformed dynamics substantially lowers the previous limits on the parameters quantifying the commutator deformation. PMID:26088965

  7. Deformation stages of technical aluminum at reverse

    NASA Astrophysics Data System (ADS)

    Vaulina, O. Yu; Durnovtseva, A. N.; Shvagrukova, E. V.

    2016-02-01

    Durability and reliability of machines and mechanisms are determined, mainly, by their fatigue resistance as far as, in the most cases, variable load impacts on machine components. Accordingly, the problem of fatigue failure is extremely topical, still. Its complexity is connected with a wide range of factors. First of all, at cyclic load the compatibility relations of a material surface layer, which is loaded over the yield point and the elastic-loaded substrate layer, play a very important role. This fact determines involvement into plastic flow and failure of all the scale hierarchy of deformation structural levels. Reverse loading under the condition of the elastic-loaded substrate layer causes strong localization of plastic deformation in the surface layers. In the deformation localization areas the material reaches its limit state, when fatigue cracks arise and expand. The paper presents the mechanisms of fatigue deformation for technical aluminum at various fatigue stages.

  8. On Isospectral Deformations of an Inhomogeneous String

    NASA Astrophysics Data System (ADS)

    Colville, Kale; Gomez, Daniel; Szmigielski, Jacek

    2016-12-01

    In this paper we consider a class of isospectral deformations of the inhomogeneous string boundary value problem. The deformations considered are generalizations of the isospectral deformation that has arisen in connection with the Camassa-Holm equation for the shallow water waves. It is proved that these new isospectral deformations result in evolution equations on the mass density whose form depends on how the string is tied at the endpoints. Moreover, it is shown that the evolution equations in this class linearize on the spectral side and hence can be solved by the inverse spectral method. In particular, the problem involving a mass density given by a discrete finite measure and arbitrary boundary conditions is shown to be solvable by Stieltjes' continued fractions.

  9. Nuclear Deformation Effects in the Cluster Radioactivity

    NASA Astrophysics Data System (ADS)

    Misicu, Serban; Protopopescu, Dan

    1999-01-01

    We investigate the influence of the nuclear deformation on the decay rates of some cluster emission processes. The interaction between the daughter and the cluster is given by a double folding potential including quadrupole and hexadecupole deformed densities of both fragments. The nuclear part of the nucleus--nucleus interaction is density dependent and at small distances a repulsive core in the potential will occur. In the frame of the WKB-approximation the assault frequency of the cluster will depend on the geometric properties of the potential pocket whereas the penetrability will be sensitive to changes in the barrier location. The results obtained in this paper point out that various combinations of cluster and daughter deformations may account for the measured values of the decay rate. The decay rates are however more sensitive to the changes in the daughter deformation due to the large mass asymmetry of the process.

  10. [Foetal akinesia-hypokinesia deformation sequence].

    PubMed

    Bayat, Allan; Petersen, Astrid; Møller, Margrethe; Andersen, Graziella; Ebbesen, Finn

    2010-05-10

    Foetal akinesia-hypokinesia deformation sequence (FADS) involves arthrogryposis, facial deformations, pulmonary hypoplasia, intrauterine growth retardation, polyhydramnios and short umbilical cord. FADS is caused by lack of foetal movements, most often due to neuromuscular diseases. FADS is associated with a high mortality rate, and the infants usually die due to pulmonary hypoplasia. Antenatal diagnosis by ultrasound is possible when the condition is pronounced, or by genetic investigation, on suspicion of a specific underlying disease with known genetics.

  11. Tidal deformability of compact boson stars

    NASA Astrophysics Data System (ADS)

    Sennett, Noah; Steinhoff, Jan; Hinderer, Tanja; Buonanno, Alessandra

    2017-01-01

    Gravitational waves can be used to probe the structure of compact objects in coalescing binary systems. This structure enters the pre-merger waveform through tidal interactions between the two bodies, characterized by each object's tidal deformability. We investigate whether these effects can differentiate binary black holes from systems containing compact boson stars. We compute the tidal deformability for various boson star models, including ultracompact non-topological solitonic solutions.

  12. Simplified solution for stresses and deformation

    NASA Technical Reports Server (NTRS)

    Hamrock, B. J.; Brewe, D. E.

    1981-01-01

    Conventional contact deformation analysis for ball bearings, gears, and cams involves tedious iterative procedures or the use of design charts. A simplified approach that makes the elastic deformation at the center of contact easy to calculate was previously reported. The range of validity in which these equations can be used is extended. A simplified approach to the calculation of the location and magnitude of subsurface stresses developed in machine element applications is included.

  13. Nanoscale Deformation and Toughening Mechanisms of Nacre

    DTIC Science & Technology

    2011-03-31

    graduating undergraduates who achieved a 3.5 GPA to 4.0 (4.0 max scale ): Number of graduating undergraduates funded by a DoD funded Center of Excellence grant...design principle down to atomic scale with a purpose to fight against foreign attacks, which has opened up a new opportunity to unravel the...deformation mechanism of unique mechanical performance at the atomic scale . Technology Transfer 1 Nanoscale Deformation and Toughening Mechanisms of Nacre

  14. Dislocations: 75 years of Deformation Mechanisms

    NASA Technical Reports Server (NTRS)

    Schneider, Judy

    2009-01-01

    The selection of papers presented in this section reflect on themes to be explored at the "Dislocations: 75 years of Deformation Mechanisms" Symposium to be held at the Annual 2009 TMS meeting. The symposium was sponsored by the Mechanical Behavior of Materials Committee to give tribute to the evolution of a concept that has formed the basis of our mechanistic understanding of how crystalline solids plastically deform and how they fail.

  15. Deformed proximity potential for heavy ion reactions

    SciTech Connect

    Baltz, A.J.

    1989-09-01

    The proximity potential is discussed for the inelastic scattering of a spherical nucleus on a deformed nucleus or the mutual interaction of two deformed nuclei. It is shown that the proximity potential is, in general, geometrically more correct than the usual centerline prescription used in inelastic scattering analyses. For the cases where the proximity potential is inadequate a folding model approach is advocated. Techniques to facilitate the coupled channels analysis are presented. 11 refs., 6 figs.

  16. Deformability curve for K18 steel

    SciTech Connect

    Pospiech, J.

    1999-12-01

    The problem of the best utilization of plasticity in plastic working processes of metals, at low resistance to deformation and maximum utilization of capacity of installations has gained great importance, especially in recent years. Determination of plasticity of materials by the method of Kolmogorow is described. Variation of the stress factor for several plastic working processes is also described. Tests to plot the deformability curve (also referred to as reserve of plasticity curve) were selected and proved.

  17. Deformable mirror for short wavelength applications

    DOEpatents

    Chapman, Henry N.; Sweeney, Donald W.

    1999-01-01

    A deformable mirror compatible with short wavelength (extreme ultraviolet) radiation that can be precisely controlled to nanometer and subnanometer accuracy is described. Actuators are coupled between a reaction plate and a face plate which has a reflective coating. A control system adjusts the voltage supplied to the actuators; by coordinating the voltages supplied to the actuators, the reflective surface of the mirror can be deformed to correct for dimensional errors in the mirror or to produce a desired contour.

  18. Noncommutative scalar fields from symplectic deformation

    SciTech Connect

    Daoud, M.; Hamama, A.

    2008-02-15

    This paper is concerned with the quantum theory of noncommutative scalar fields in two dimensional space-time. It is shown that the noncommutativity originates from the the deformation of symplectic structures. The quantization is performed and the modes expansions of the fields, in the presence of an electromagnetic background, are derived. The Hamiltonian of the theory is given and the degeneracies lifting, induced by the deformation, is also discussed.

  19. Thermal elastic deformations of the planet Mercury.

    NASA Technical Reports Server (NTRS)

    Liu, H.-S.

    1972-01-01

    The variation in solar heating due to the resonance rotation of Mercury produces periodic elastic deformations on the surface of the planet. The thermal stress and strain fields under Mercury's surface are calculated after certain simplifications. It is found that deformations penetrate to a greater depth than the variation of solar heating, and that the thermal strain on the surface of the planet pulsates with an amplitude of .004 and a period of 176 days.

  20. Thermal elastic deformations of the planet Mercury

    NASA Technical Reports Server (NTRS)

    Liu, H.

    1971-01-01

    The variation in solar heating due to the resonance rotation of Mercury produces periodic elastic deformations on the surface of the planet. The thermal stress and strain fields under Mercury's surface are calculated after certain simplifications. It is shown that deformations penetrate to a greater depth than the variation of solar heating, and that the thermal strain on the surface of the planet pulsates with an amplitude of 0.004 and a period of 176 days.

  1. Intraoperative measurement of indenter-induced brain deformation: a feasibility study

    NASA Astrophysics Data System (ADS)

    Ji, Songbai; Fan, Xiaoyao; Roberts, David W.; Paulsen, Keith D.

    2014-03-01

    Accurate measurement of soft tissue material properties is critical for characterizing its biomechanical behaviors but can be challenging especially for the human brain in vivo. In this study, we investigated the feasibility of inducing and detecting cortical surface deformation intraoperatively for patients undergoing open skull neurosurgeries. A custom diskshaped indenter made of high-density tungsten (diameter of 15 mm with a thickness of 6 mm) was used to induce deformation on the brain cortical surface immediately after dural opening. Before and after placing the indenter, sequences (typically 250 frames at 15 frames-per-second, or ~17 seconds) of high-resolution stereo image pairs were acquired to capture the harmonic motion of the exposed cortical surface as due to blood pressure pulsation and respiration. For each sequence with the first left image serving as a baseline, an optical-flow motion-tracking algorithm was used to detect in-sequence cortical surface deformation. The resulting displacements of the exposed features within the craniotomy were spatially averaged to identify the temporal frames corresponding to motion peak magnitudes. Corresponding image pairs were then selected to reconstruct full-field three-dimensional (3D) cortical surfaces before and after indentation, respectively, from which full 3D displacement fields were obtained by registering their projection images. With one clinical patient case, we illustrate the feasibility of the technique in detecting indenter-induced cortical surface deformation in order to allow subsequent processing to determine material properties of the brain in vivo.

  2. Deformation of the Augustine Volcano, Alaska, 1992-2005, measured by ERS and ENVISAT SAR interferometry

    USGS Publications Warehouse

    Lee, Chang-Wook; Lu, Zhong; Kwoun, Oh-Ig; Won, Joong-Sun

    2008-01-01

    The Augustine Volcano is a conical-shaped, active stratovolcano located on an island of the same name in Cook Inlet, about 290 km southwest of Anchorage, Alaska. Augustine has experienced seven significant explosive eruptions - in 1812, 1883, 1908, 1935, 1963, 1976, 1986, and in January 2006. To measure the ground surface deformation of the Augustine Volcano before the 2006 eruption, we applied satellite radar interferometry using Synthetic Aperture Radar (SAR) images from three descending and three ascending satellite tracks acquired by European Remote Sensing Satellite (ERS) 1 and 2 and the Environment Satellite (ENVISAT). Multiple interferograms were stacked to reduce artifacts caused by atmospheric conditions, and we used a singular value decomposition method to retrieve the temporal deformation history from several points on the island. Interferograms during 1992 and 2005 show a subsidence of about 1-3 cm/year, caused by the contraction of pyroclastic flow deposits from the 1986 eruption. Subsidence has decreased exponentially with time. Multiple interferograms between 1992 and 2005 show no significant inflation around the volcano before the 2006 eruption. The lack of a pre-eruption deformation signal suggests that the deformation signal from 1992 to August 2005 must have been very small and may have been obscured by atmospheric delay artifacts. 

  3. Advances and challenges in deformable image registration: From image fusion to complex motion modelling.

    PubMed

    Schnabel, Julia A; Heinrich, Mattias P; Papież, Bartłomiej W; Brady, Sir J Michael

    2016-10-01

    Over the past 20 years, the field of medical image registration has significantly advanced from multi-modal image fusion to highly non-linear, deformable image registration for a wide range of medical applications and imaging modalities, involving the compensation and analysis of physiological organ motion or of tissue changes due to growth or disease patterns. While the original focus of image registration has predominantly been on correcting for rigid-body motion of brain image volumes acquired at different scanning sessions, often with different modalities, the advent of dedicated longitudinal and cross-sectional brain studies soon necessitated the development of more sophisticated methods that are able to detect and measure local structural or functional changes, or group differences. Moving outside of the brain, cine imaging and dynamic imaging required the development of deformable image registration to directly measure or compensate for local tissue motion. Since then, deformable image registration has become a general enabling technology. In this work we will present our own contributions to the state-of-the-art in deformable multi-modal fusion and complex motion modelling, and then discuss remaining challenges and provide future perspectives to the field.

  4. Analysis of deformation patterns through advanced DINSAR techniques in Istanbul megacity

    NASA Astrophysics Data System (ADS)

    Balik Sanli, F.; Calò, F.; Abdikan, S.; Pepe, A.; Gorum, T.

    2014-09-01

    As result of the Turkey's economic growth and heavy migration processes from rural areas, Istanbul has experienced a high urbanization rate, with severe impacts on the environment in terms of natural resources pressure, land-cover changes and uncontrolled sprawl. As a consequence, the city became extremely vulnerable to natural and man-made hazards, inducing ground deformation phenomena that threaten buildings and infrastructures and often cause significant socio-economic losses. Therefore, the detection and monitoring of such deformation patterns is of primary importance for hazard and risk assessment as well as for the design and implementation of effective mitigation strategies. Aim of this work is to analyze the spatial distribution and temporal evolution of deformations affecting the Istanbul metropolitan area, by exploiting advanced Differential SAR Interferometry (DInSAR) techniques. In particular, we apply the Small BAseline Subset (SBAS) approach to a dataset of 43 TerraSAR-X images acquired, between November 2010 and June 2012, along descending orbits with an 11-day revisit time and a 3 m × 3 m spatial resolution. The SBAS processing allowed us to remotely detect and monitor subsidence patterns over all the urban area as well as to provide detailed information at the scale of the single building. Such SBAS measurements, effectively integrated with ground-based monitoring data and thematic maps, allows to explore the relationship between the detected deformation phenomena and urbanization, contributing to improve the urban planning and management.

  5. NANOSECOND INTERFEROMETRIC STUDIES OF SURFACE DEFORMATIONS OF DIELECTRICS INDUCED BY LASER IRRADIATION

    SciTech Connect

    S. GREENFIELD; ET AL

    2000-05-01

    Transient surface deformations in dielectric materials induced by laser irradiation were investigated with time-resolved interferometry. Deformation images were acquired at various delay times after exposure to single pulses (100 ps at 1.064 {micro}m) on fresh sample regions. Above the ablation threshold, we observe prompt ejection of material and the formation of a single unipolar compressional surface acoustic wave propagating away from the ablation crater. For calcite, no deformation--either transient or permanent--is discernable at laser fluences below the threshold for material ejection. Above and below-threshold behavior was investigated using a phosphate glass sample with substantial near infrared absorption (Schott filter KG3). Below threshold, KG3 exhibits the formation of a small bulge roughly the size of the laser spot that reaches its maximum amplitude by {approx}5 ns. By tens of nanoseconds, the deformations become quite complex and very sensitive to laser fluence. The above-threshold behavior of KG3 combines the ablation-induced surface acoustic wave seen in calcite with the bulge seen below threshold in KG3. A velocity of 2.97 {+-} 0.03 km/s is measured for the KG3 surface acoustic wave, very close to the Rayleigh wave velocity calculated from material elastic parameters. Details of the transient interferometry system will also be given.

  6. Quantum deformations of the flat space superstring

    NASA Astrophysics Data System (ADS)

    Pachoł, Anna; van Tongeren, Stijn J.

    2016-01-01

    We discuss a quantum deformation of the Green-Schwarz superstring on flat space, arising as a contraction limit of the corresponding deformation of AdS5×S5 . This contraction limit turns out to be equivalent to a previously studied limit that yields the so-called mirror model—the model obtained from the light cone gauge fixed AdS5×S5 string by a double Wick rotation. Reversing this logic, the AdS5×S5 superstring is the double Wick rotation of a quantum deformation of the flat space superstring. This quantum deformed flat space string realizes symmetries of the timelike κ -Poincaré type and is T dual to dS5×H5, indicating interesting relations between symmetry algebras under T duality. Our results directly extend to AdS2×S2×T6 and AdS3×S3×T4 and beyond string theory to many (semi)symmetric space coset sigma models, such as a deformation of the four-dimensional Minkowski sigma model with timelike κ -Poincaré symmetry. We also discuss possible null and spacelike deformations.

  7. Osteogenesis imperfecta: a case with hand deformities.

    PubMed

    Oz, Bengi; Olmez, Nese; Memis, Asuman

    2005-09-01

    In a 51-year-old woman with a history of fractures and dislocations after low intensity trauma in childhood, intensive blue sclera, short stature, and hearing loss, the diagnosis of osteogenesis imperfecta (OI) was suspected. She was referred to our clinic with hand deformities and left knee pain and stiffness. She had difficulty in walking and reported a history of immobilization for 6 months because of knee pain. She had bilateral flexion contracture of the elbows which occurred following dislocations of the elbows in childhood. She had Z deformity of the first phalanges, reducible swan-neck deformity of the third finger of the left and the second finger of the right hand, flexion contracture of the proximal interphalangeal joint of the fifth finger of the left hand, and syndactyly of the third and fourth fingers of the right hand. Flexion contractures of both knees were observed. Pes planus and short toes were the deformities of the feet. Acute phase reactants of the patient were normal. She had no history of arthritis or morning stiffness. Bone mineral density evaluated by dual-energy X-ray absorptiometry (DEXA) showed severe osteoporosis of the femur and lumbar vertebrae. She had radiographic evidence of healed fractures of the left fibula, the third metacarpal, and the fourth and fifth middle phalanges of the right hand. OI, affecting the type I collagen tissue of the sclera, skin, ligaments, and skeleton, presenting with ligament laxity resulting in subluxations and hand deformities may be misdiagnosed as hand deformities of rheumatoid arthritis.

  8. Bialgebra cohomology, deformations, and quantum groups.

    PubMed Central

    Gerstenhaber, M; Schack, S D

    1990-01-01

    We introduce cohomology and deformation theories for a bialgebra A (over a commutative unital ring k) such that the second cohomology group is the space of infinitesimal deformations. Our theory gives a natural identification between the underlying k-modules of the original and the deformed bialgebra. Certain explicit deformation formulas are given for the construction of quantum groups--i.e., Hopf algebras that are neither commutative nor cocommutative (whether or not they arise from quantum Yang-Baxter operators). These formulas yield, in particular, all GLq(n) and SLq(n) as deformations of GL(n) and SL(n). Using a Hodge decomposition of the underlying cochain complex, we compute our cohomology for GL(n). With this, we show that every deformation of GL(n) is equivalent to one in which the comultiplication is unchanged, not merely on elements of degree one but on all elements (settling in the strongest way a decade-old conjecture) and in which the quantum determinant, as an element of the underlying k-module, is identical with the usual one. PMID:11607053

  9. Probing Cell Deformability via Acoustically Actuated Bubbles

    PubMed Central

    Xie, Yuliang; Nama, Nitesh; Li, Peng; Mao, Zhangming; Huang, Po-Hsun; Zhao, Chenglong; Costanzo, Francesco; Huang, Tony Jun

    2016-01-01

    An acoustically actuated, bubble-based technique is developed to investigate the deformability of cells suspended in microfluidic devices. A microsized bubble is generated by an optothermal effect near the targeted cells, which are suspended in a microfluidic chamber. Subsequently, acoustic actuation is employed to create localized acoustic streaming. In turn, the streaming flow results in hydrodynamic forces that deform the cells in situ. The deformability of the cells is indicative of their mechanical properties. The method in this study measures mechanical biomarkers from multiple cells in a single experiment, and it can be conveniently integrated with other bioanalysis and drug-screening platforms. Using this technique, the mean deformability of tens of HeLa, HEK, and HUVEC cells is measured to distinguish their mechanical properties. HeLa cells are deformed upon treatment with Cytochalasin. The technique also reveals the deformability of each subpopulation in a mixed, heterogeneous cell sample by the use of both fluorescent markers and mechanical biomarkers. The technique in this study, apart from being relevant to cell biology, will also enable biophysical cellular diagnosis. PMID:26715211

  10. Rheumatoid Hand Deformities: Pathophysiology and Treatment

    PubMed Central

    Apfelberg, David B.; Maser, Morton R.; Lash, Harvey; Kaye, Ronald L.; Britton, Melvin C.; Bobrove, Arthur

    1978-01-01

    Rheumatoid disease, as it affects the hand, is a disease of the synovium lining the joints and sheaths of the tendon. The proliferating synovium destroys the articular surfaces of the joint, interferes with the gliding mechanism of the tendons and weakens the supporting ligaments of the joints. The degree and variety of deformities is multifold. Treatment of the rheumatoid hand is aimed at conservation and restoration of hand function, as well as prevention of future deformities. Rheumatologists, physical therapists and hand surgeons carry out important functions in the well-planned, integrated regimen. Surgical treatment of the rheumatoid hand deformity may alleviate pain, lessen deformity and improve function in selected cases. It should be integrated in the general medical management of a patient. Treatment of tendon ruptures includes tenorrhaphy, tendon grafting and arthrodesis in the case of mallet finger deformity. The wrist joint is improved by synovectomy and carpal tunnel release is accomplished by median nerve decompression. Metacarpal phalangeal joint deformities may be treated by synovectomy or silastic joint replacement when there is destruction of the articular joint surface, severe subluxation, or persistent painful motion. ImagesFigure 1.Figure 2.Figure 3.Figure 4.Figure 5. PMID:716388

  11. Sr and Nd isotope composition of deformed peridotite xenoliths from Udachnaya kimberlite pipe

    NASA Astrophysics Data System (ADS)

    Surgutanova, E. A.; Agashev, A. M.; Demonterova, E. I.; Golovin, A. V.; Pokhilenko, N. P.

    2016-11-01

    New results of Rb-Sr and Sm-Nd isotope analyses have been obtained on samples of deformed peridotite xenoliths collected from the Udachnaya kimberlite pipe (Yakutia). The data obtained imply two main stages of metasomatic alteration of the lithospheric mantle base matter in the central part of the Siberian Craton. Elevated ratios of Sr isotopes may be considered as evidence of an ancient stage of metasomatic enrichment by a carbonatite melt. The acquired Nd isotope composition together with the geochemistry of the deformed peridotite xenoliths suggests that the second stage of metasomatic alteration took place shortly before formation of the kimberlite melt. The metasomatic agent of this stage had a silicate character and arrived from an asthenosphere source, common for the normal OIB type (PREMA) and the Group-I kimberlite.

  12. Gaze-contingent soft tissue deformation tracking for minimally invasive robotic surgery.

    PubMed

    Mylonas, George P; Stoyanov, Danail; Deligianni, Fani; Darzi, Ara; Yang, Guang-Zhong

    2005-01-01

    The introduction of surgical robots in Minimally Invasive Surgery (MIS) has allowed enhanced manual dexterity through the use of microprocessor controlled mechanical wrists. Although fully autonomous robots are attractive, both ethical and legal barriers can prohibit their practical use in surgery. The purpose of this paper is to demonstrate that it is possible to use real-time binocular eye tracking for empowering robots with human vision by using knowledge acquired in situ. By utilizing the close relationship between the horizontal disparity and the depth perception varying with the viewing distance, it is possible to use ocular vergence for recovering 3D motion and deformation of the soft tissue during MIS procedures. Both phantom and in vivo experiments were carried out to assess the potential frequency limit of the system and its intrinsic depth recovery accuracy. The potential applications of the technique include motion stabilization and intra-operative planning in the presence of large tissue deformation.

  13. Deform PF-MT: Particle Filter With Mode Tracker for Tracking Nonaffine Contour Deformations

    PubMed Central

    Vaswani, Namrata; Rathi, Yogesh; Yezzi, Anthony; Tannenbaum, Allen

    2013-01-01

    We propose algorithms for tracking the boundary contour of a deforming object from an image sequence, when the nonaffine (local) deformation over consecutive frames is large and there is overlapping clutter, occlusions, low contrast, or outlier imagery. When the object is arbitrarily deforming, each, or at least most, contour points can move independently. Contour deformation then forms an infinite (in practice, very large), dimensional space. Direct application of particle filters (PF) for large dimensional problems is impractically expensive. However, in most real problems, at any given time, most of the contour deformation occurs in a small number of dimensions (“effective basis space”) while the residual deformation in the rest of the state space (“residual space”) is small. This property enables us to apply the particle filtering with mode tracking (PF-MT) idea that was proposed for such large dimensional problems in recent work. Since most contour deformation is low spatial frequency, we propose to use the space of deformation at a subsampled set of locations as the effective basis space. The resulting algorithm is called deform PF-MT. It requires significant modifications compared to the original PF-MT because the space of contours is a non-Euclidean infinite dimensional space. PMID:19933014

  14. Multidimensional Time Series Analysis Of Ground Deformation From Multiple InSAR Data Sets Applied To Virunga Volcanic Province

    NASA Astrophysics Data System (ADS)

    d'Oreye, N.; Samsonov, S. V.; Benoît, S.

    2012-12-01

    A novel, Multidimensional Small Baseline Subset (MSBAS), methodology is presented for integration of multiple InSAR data sets for computation of two or three dimensional time series of deformation (Samsonov and d'Oreye, Resubmitted). The approach allows combination of all possible air-borne and space-borne SAR data acquired with different acquisition parameters, temporal and spatial sampling and resolution, wave-band and polarization. The proposed method has four main advantages: 1) it achieves combined temporal coverage over an extended period of time when data from many different sensors with different temporal coverages are available; 2) temporal resolution of produced time series increases since it includes the combined sampling from all data sets, which helps to observe signal in more details and also to improve the quality of post-processing (i.e. filtering); 3) two or three components of ground deformation vector are computed, which helps in interpretation of observed ground deformation and further modeling and inversion; 4) various sources of noise (i.e. tropospheric, ionospheric, topographic, orbital, thermal, etc.) are averaged out during the processing improving a signal-to-noise ratio. We apply this technique to SAR data acquired by ERS-1/2, ENVISAT, Radarsat-2 and ALOS starting from March of 2003 until July 2010 over Virunga Volcanic Province (DR Congo) in order to produce time series of ground deformation. The horizontal and vertical time series of ground displacement clearly identify lava compaction areas, long-term deformation of Mt. Nyamulagira and deformations associated to 2004, 2006 and 2010 Nyamulagira eruptions. The method also reveals first unambiguous pre-eruptive deformations in the Virunga Volcanic Province. In particular, pre-eruptive signals are detected about 15 days prior the onset of Nyamulagira 2010 eruption by three successive satellite images acquired by three different sensors in different geometries while the seismic precursors

  15. GETTING LOST: TOPOGRAPHIC SKILLS IN ACQUIRED AND DEVELOPMENTAL PROSOPAGNOSIA

    PubMed Central

    Lee, Edison; Pancaroglu, Raika; Burles, Ford; Duchaine, Brad; Iaria, Giuseppe; Barton, Jason J S

    2016-01-01

    Previous studies report that acquired prosopagnosia is frequently associated with topographic disorientation. Whether this is associated with a specific anatomic subtype of prosopagnosia, how frequently it is seen with the developmental variant, and what specific topographic function is impaired to account for this problem are not known. We studied ten subjects with acquired prosopagnosia from either occipitotemporal or anterior temporal lesions and seven with developmental prosopagnosia. Subjects were given a battery of topographic tests, including house and scene recognition, the road map test, a test of cognitive map formation, and a standardized self-report questionnaire. House and/or scene recognition were frequently impaired after either occipitotemporal or anterior temporal lesions in acquired prosopagnosia. Subjects with occipitotemporal lesions were also impaired in cognitive map formation: an overlap analysis identified right fusiform and parahippocampal gyri as a likely correlate. Only one subject with acquired prosopagnosia had mild difficulty with directional orientation on the road map test. Only one subject with developmental prosopagnosia had difficulty with cognitive map formation, and none were impaired on the other tests. Scores for house and scene recognition correlated most strongly with the results of the questionnaire. We conclude that topographic disorientation in acquired prosopagnosia reflects impaired place recognition, with a contribution from poor cognitive map formation when there is occipitotemporal damage. Topographic impairments are less frequent in developmental prosopagnosia. PMID:26874939

  16. Connectionist neuropsychology: uncovering ultimate causes of acquired dyslexia

    PubMed Central

    Woollams, Anna M.

    2014-01-01

    Acquired dyslexia offers a unique window on to the nature of the cognitive and neural architecture supporting skilled reading. This paper provides an integrative overview of recent empirical and computational work on acquired dyslexia within the context of the primary systems framework as implemented in connectionist neuropsychological models. This view proposes that damage to general visual, phonological or semantic processing abilities are the root causes of different forms of acquired dyslexia. Recent case-series behavioural evidence concerning pure alexia, phonological dyslexia and surface dyslexia that supports this perspective is presented. Lesion simulations of these findings within connectionist models of reading demonstrate the viability of this approach. The commitment of such models to learnt representations allows them to capture key aspects of performance in each type of acquired dyslexia, particularly the associated non-reading deficits, the role of relearning and the influence of individual differences in the premorbid state of the reading system. Identification of these factors not only advances our understanding of acquired dyslexia and the mechanisms of normal reading but they are also relevant to the complex interactions underpinning developmental reading disorders. PMID:24324241

  17. Connectionist neuropsychology: uncovering ultimate causes of acquired dyslexia.

    PubMed

    Woollams, Anna M

    2014-01-01

    Acquired dyslexia offers a unique window on to the nature of the cognitive and neural architecture supporting skilled reading. This paper provides an integrative overview of recent empirical and computational work on acquired dyslexia within the context of the primary systems framework as implemented in connectionist neuropsychological models. This view proposes that damage to general visual, phonological or semantic processing abilities are the root causes of different forms of acquired dyslexia. Recent case-series behavioural evidence concerning pure alexia, phonological dyslexia and surface dyslexia that supports this perspective is presented. Lesion simulations of these findings within connectionist models of reading demonstrate the viability of this approach. The commitment of such models to learnt representations allows them to capture key aspects of performance in each type of acquired dyslexia, particularly the associated non-reading deficits, the role of relearning and the influence of individual differences in the premorbid state of the reading system. Identification of these factors not only advances our understanding of acquired dyslexia and the mechanisms of normal reading but they are also relevant to the complex interactions underpinning developmental reading disorders.

  18. Diminished acquired equivalence yet good discrimination performance in older participants.

    PubMed

    Robinson, Jasper; Owens, Emma

    2013-01-01

    We asked younger and older human participants to perform computer-based configural discriminations that were designed to detect acquired equivalence. Both groups solved the discriminations but only the younger participants demonstrated acquired equivalence. The discriminations involved learning the preferences ["like" (+) or "dislike" (-)] for sports [e.g., tennis (t) and hockey (h)] of four fictitious people [e.g., Alice (A), Beth (B), Charlotte (C), and Dorothy (D)]. In one experiment, the discrimination had the form: At+, Bt-, Ct+, Dt-, Ah-, Bh+, Ch-, Dh+. Notice that, e.g., Alice and Charlotte are "equivalent" in liking tennis but disliking hockey. Acquired equivalence was assessed in ancillary components of the discrimination (e.g., by looking at the subsequent rate of "whole" versus "partial" reversal learning). Acquired equivalence is anticipated by a network whose hidden units are shared when inputs (e.g., A and C) signal the same outcome (e.g., +) when accompanied by the same input (t). One interpretation of these results is that there are age-related differences in the mechanisms of configural acquired equivalence.

  19. Getting lost: Topographic skills in acquired and developmental prosopagnosia.

    PubMed

    Corrow, Jeffrey C; Corrow, Sherryse L; Lee, Edison; Pancaroglu, Raika; Burles, Ford; Duchaine, Brad; Iaria, Giuseppe; Barton, Jason J S

    2016-03-01

    Previous studies report that acquired prosopagnosia is frequently associated with topographic disorientation. Whether this is associated with a specific anatomic subtype of prosopagnosia, how frequently it is seen with the developmental variant, and what specific topographic function is impaired to account for this problem are not known. We studied ten subjects with acquired prosopagnosia from either occipitotemporal or anterior temporal (AT) lesions and seven with developmental prosopagnosia. Subjects were given a battery of topographic tests, including house and scene recognition, the road map test, a test of cognitive map formation, and a standardized self-report questionnaire. House and/or scene recognition were frequently impaired after either occipitotemporal or AT lesions in acquired prosopagnosia. Subjects with occipitotemporal lesions were also impaired in cognitive map formation: an overlap analysis identified right fusiform and parahippocampal gyri as a likely correlate. Only one subject with acquired prosopagnosia had mild difficulty with directional orientation on the road map test. Only one subject with developmental prosopagnosia had difficulty with cognitive map formation, and none were impaired on the other tests. Scores for house and scene recognition correlated most strongly with the results of the questionnaire. We conclude that topographic disorientation in acquired prosopagnosia reflects impaired place recognition, with a contribution from poor cognitive map formation when there is occipitotemporal damage. Topographic impairments are less frequent in developmental prosopagnosia.

  20. Elevated and Low Temperature Deformation of Cast Depleted Uranium

    SciTech Connect

    Vogel, Sven C.

    2015-02-20

    Goals: Understand crystal structure and micro-structure changes during high and low temperature deformation of uranium, in particular texture, and develop constitutive micro-structure based model for uranium deformation. Deliverables achieved: Completed texture measures for 11 pre- and post-dU compression samples, quantified texture pre- and post-deformation, and provided data to constrain deformation models.