Science.gov

Sample records for acquiring high quality

  1. Acquire High Quality Meshes of Scale Models for AN Automatic Modelling Process

    NASA Astrophysics Data System (ADS)

    Giraud, F.; Jacquot, K.; Chevrier, C.; Halin, G.

    2013-07-01

    Urban scale models depicting whole towns such as the hundred-scale model collection known as plans-reliefs are a valuable source of information of cities and their surroundings. These physical representations of French strongholds from the 17th through the 19th century suffer from many problems that are, among other things, wear and tear or the lack of visibility and accessibility. A virtual collection would allow remote accessibility for visitors as well as history researchers. Moreover, it may also be linked to other digital collections and therefore, promote the collection to make people come to the museums to see the physical scale models. We also work on other physical town scale models like Epinal for which the scale is a bit higher. In a first part, we define a protocol for acquiring 3D meshes of town scale models from both photogrammetric and scanning methods. Then we compare the results of both methods The photogrammetric protocol has been elaborated by choosing the most accurate software, 123DCatch, which asks for about 60 pictures, and defining the settings needed to obtain exploitable photographs. In the same way, we defined the devices and settings needed for the laser scan acquisition method. In a second part, we segment the 3D meshes in planes by using Geomagic, which has been chosen between several programs, for its accurate resulting geometry.

  2. Requirements for acquiring a high-quality house dust mite extract for allergen immunotherapy

    PubMed Central

    Frati, Franco; Incorvaia, Cristoforo; David, Marie; Scurati, Silvia; Seta, Simona; Padua, Guglielmo; Cattaneo, Eleonora; Cavaliere, Carlo; Di Rienzo, Alessia; Dell’Albani, Ilaria; Puccinelli, Paola

    2012-01-01

    The house dust mite is a major cause of respiratory allergy worldwide. The management of mite allergy is based on avoidance measures, drug treatment, and allergen immunotherapy, but only allergen immunotherapy is able to modify the natural history of the disease. Injectable subcutaneous immunotherapy was introduced a century ago, while sublingual immunotherapy was proposed in the 1980s and emerged in the ensuing years as an effective and safe option to subcutaneous immunotherapy. However, the quality of the extracts to be used in allergen immunotherapy is crucial for the success of treatment. The mite extract for sublingual immunotherapy known as Staloral 300 was developed to offer optimal characteristics concerning the mite culture medium, standardization, and allergen dose. Double-blind, placebo-controlled trials with Staloral 300 have provided a substantial part of the clinical evidence analyzed in a meta-analysis of the efficacy of allergen immunotherapy in mite-induced rhinitis and asthma. Safety and tolerability are very good, mild local reactions in the mouth being the most common side effect. This makes it feasible to carry out sublingual immunotherapy for the 3–5-year duration needed to achieve long-lasting tolerance to the specific allergen. The performance of Staloral 300 may provide optimal conditions for an effective and safe sublingual immunotherapy in patients with mite-induced respiratory allergy. PMID:22654506

  3. Automated quality assessment of autonomously acquired microscopic images of fluorescently stained bacteria.

    PubMed

    Zeder, M; Kohler, E; Pernthaler, J

    2010-01-01

    Quality assessment of autonomously acquired microscopic images is an important issue in high-throughput imaging systems. For example, the presence of low quality images (>or=10%) in a dataset significantly influences the counting precision of fluorescently stained bacterial cells. We present an approach based on an artificial neural network (ANN) to assess the quality of such images. Spatially invariant estimators were extracted as ANN input data from subdivided images by low level image processing. Different ANN designs were compared and >400 ANNs were trained and tested on a set of 25,000 manually classified images. The optimal ANN featured a correct identification rate of 94% (3% false positives, 3% false negatives) and could process about 10 images per second. We compared its performance with the image quality assessment by different humans and discuss the difficulties in assigning images to the correct quality class. The computer program and the documented source code (VB.NET) are provided under General Public Licence.

  4. LEDs as light source: examining quality of acquired images

    NASA Astrophysics Data System (ADS)

    Bachnak, Rafic; Funtanilla, Jeng; Hernandez, Jose

    2004-05-01

    Recent advances in technology have made light emitting diodes (LEDs) viable in a number of applications, including vehicle stoplights, traffic lights, machine-vision-inspection, illumination, and street signs. This paper presents the results of comparing images taken by a videoscope using two different light sources. One of the sources is the internal metal halide lamp and the other is a LED placed at the tip of the insertion tube. Images acquired using these two light sources were quantitatively compared using their histogram, intensity profile along a line segment, and edge detection. Also, images were qualitatively compared using image registration and transformation. The gray-level histogram, edge detection, image profile and image registration do not offer conclusive results. The LED light source, however, produces good images for visual inspection by an operator. The paper will present the results and discuss the usefulness and shortcomings of various comparison methods.

  5. CMS Nonpayment Policy, Quality Improvement, and Hospital-Acquired Conditions: An Integrative Review.

    PubMed

    Bae, Sung-Heui

    This integrative review synthesized evidence on the consequences of the Centers for Medicare & Medicaid Services (CMS) nonpayment policy on quality improvement initiatives and hospital-acquired conditions. Fourteen articles were included. This review presents strong evidence that the CMS policy has spurred quality improvement initiatives; however, the relationships between the CMS policy and hospital-acquired conditions are inconclusive. In future research, a comprehensive model of implementation of the CMS nonpayment policy would help us understand the effectiveness of this policy.

  6. Small UAV-Acquired, High-resolution, Georeferenced Still Imagery

    SciTech Connect

    Ryan Hruska

    2005-09-01

    Currently, small Unmanned Aerial Vehicles (UAVs) are primarily used for capturing and down-linking real-time video. To date, their role as a low-cost airborne platform for capturing high-resolution, georeferenced still imagery has not been fully utilized. On-going work within the Unmanned Vehicle Systems Program at the Idaho National Laboratory (INL) is attempting to exploit this small UAV-acquired, still imagery potential. Initially, a UAV-based still imagery work flow model was developed that includes initial UAV mission planning, sensor selection, UAV/sensor integration, and imagery collection, processing, and analysis. Components to support each stage of the work flow are also being developed. Critical to use of acquired still imagery is the ability to detect changes between images of the same area over time. To enhance the analysts’ change detection ability, a UAV-specific, GIS-based change detection system called SADI or System for Analyzing Differences in Imagery is under development. This paper will discuss the associated challenges and approaches to collecting still imagery with small UAVs. Additionally, specific components of the developed work flow system will be described and graphically illustrated using varied examples of small UAV-acquired still imagery.

  7. Evaluating the image quality of cone beam CT acquired during rotational delivery

    PubMed Central

    Maria Das, K J; Maria Midunvaleja, K; Gowtham Raj, D; Agarwal, Arpita; Velmurugan, J; Kumar, Shaleen

    2015-01-01

    Objective: The aim of this work was to evaluate the quality of kilovoltage (kV) cone beam CT (CBCT) images acquired during arc delivery. Methods: Arc plans were delivered on a Catphan® 600 phantom (The Phantom Laboratory Inc., Salem, NY), and kV CBCT images were acquired during the treatment. The megavoltage (MV) scatter effect on kV CBCT image quality was evaluated using parameters such as Hounsfield unit (HU) accuracy, spatial resolution, contrast-to-noise ratio (CNR) and spatial non-uniformity (SNU). These CBCT images were compared with reference scans acquired with the same acquisition parameters without MV “beam on”. This evaluation was carried out for different photon beams (6 and 15 MV), arc types (half vs full arc), static field sizes (10 × 10 and 25 × 25 cm2) and source-to-imager distances (SID) (150 and 170 cm). Results and Conclusion: HU accuracy, CNR and SNU were considerably affected by MV scatter, and this effect was increased with increasing field size and decreasing photon energy, whereas the spatial resolution was almost unchanged. The MV scatter effect was observed to be more for full-rotation arc delivery than for half-arc delivery. In addition, increasing the SID resulted in decreased MV scatter effect and improved the image quality. Advances in knowledge: Nowadays, volumetric modulated arc therapy (VMAT) is increasingly used in clinics, and this arc therapy enables us to acquire CBCT imaging simultaneously. But, the main issue of concurrent imaging is the “MV scatter” effect on CBCT imaging. This study aims to experimentally quantify the effect of MV scatter on CBCT image quality. PMID:26226396

  8. Reducing iatrogenic risks: ICU-acquired delirium and weakness--crossing the quality chasm.

    PubMed

    Vasilevskis, Eduard E; Ely, E Wesley; Speroff, Theodore; Pun, Brenda T; Boehm, Leanne; Dittus, Robert S

    2010-11-01

    ICUs are experiencing an epidemic of patients with acute brain dysfunction (delirium) and weakness, both associated with increased mortality and long-term disability. These conditions are commonly acquired in the ICU and are often initiated or exacerbated by sedation and ventilation decisions and management. Despite > 10 years of evidence revealing the hazards of delirium, the quality chasm between current and ideal processes of care continues to exist. Monitoring of delirium and sedation levels remains inconsistent. In addition, sedation, ventilation, and physical therapy practices proven successful at reducing the frequency and severity of adverse outcomes are not routinely practiced. In this article, we advocate for the adoption and implementation of a standard bundle of ICU measures with great potential to reduce the burden of ICU-acquired delirium and weakness. Individual components of this bundle are evidence based and can help standardize communication, improve interdisciplinary care, reduce mortality, and improve cognitive and functional outcomes. We refer to this as the "ABCDE bundle," for awakening and breathing coordination, delirium monitoring, and exercise/early mobility. This evidence-based bundle of practices will build a bridge across the current quality chasm from the "front end" to the "back end" of critical care and toward improved cognitive and functional outcomes for ICU survivors.

  9. Multispectral photometric stereo for acquiring high-fidelity surface normals.

    PubMed

    Nam, Giljoo; Kim, Min H

    2014-01-01

    Multispectral imaging and photometric stereo are common in 3D imaging but rarely have been combined. Reconstructing a 3D object's shape using photometric stereo is challenging owing to indirect illumination, specular reflection, and self-shadows, and removing interreflection in photometric stereo is problematic. A new multispectral photometric-stereo method removes interreflection on diffuse materials using multispectral-reflectance information and reconstructs 3D shapes with high accuracy. You can integrate this method into photometric-stereo systems by simply substituting the original camera with a multispectral camera.

  10. Lift outs: how to acquire a high-functioning team.

    PubMed

    Groysberg, Boris; Abrahams, Robin

    2006-12-01

    More and more, expanding companies are hiring high-functioning groups of people who have been working together effectively within one company and can rapidly come up to speed in a new environment. These lifted-out teams don't need to get acquainted with one another or to establish shared values, mutual accountability, or group norms; their long-standing relationships and trust help them make an impact very quickly. Of course, the process is not without risks: A failed lift out can lead to loss of money, opportunity, credibility, and even native talent. Boris Groysberg and Robin Abrahams studied more than 40 high-profile moves and interviewed team leaders in multiple industries and countries to examine the risks and opportunities that lift outs present. They concluded that, regardless of industry, nationality, or size of the team, a successful lift out unfolds over four consecutive, interdependent stages that must be meticulously managed. In the courtship stage, the hiring company and the leader of the targeted team determine whether the proposed move is, in fact, a good idea, and then define their business goals and discuss strategies. At the same time, the team leader discusses the potential move with the other members of his or her group to assess their level of interest and prepare them for the change. The second stage involves the integration of the team leader with the new company's top leadership. This part of the process ensures the team's access to senior executives-the most important factor in a lift out's success. Operational integration is the focus of the third stage. Ideally, teams will start out working with the same or similar clients, vendors, and industry standards. The fourth stage entails full cultural integration. To succeed, the lifted-out team members must be willing to re-earn credibility by proving their value and winning their new colleagues' trust.

  11. The impact of acquired brain damage in terms of epidemiology, economics and loss in quality of life

    PubMed Central

    2011-01-01

    Background Patients with acquired brain damage (ABD) have suffered a brain lesion that interrupts vital development in the physical, psychological and social spheres. Stroke and traumatic brain injury (TBI) are the two main causes. The objectives of this study were to estimate the incidence and prevalence of ABD in the population of the Basque Country and Navarre in 2008, to calculate the associated cost of the care required and finally to assess the loss in health-related quality of life. Methods On the one hand, a cross-sectional survey was carried out, in order to estimate the incidence of ABD and its consequences in terms of costs and loss in quality of life from the evolution of a sample of patients diagnosed with stroke and TBI. On the other hand, a discrete event simulation model was built that enabled the prevalence of ABD to be estimated. Finally, a calculation was made of the formal and informal costs of ABD in the population of the Basque Country and Navarre (2,750,000 people). Results The cross-sectional study showed that the incidences of ABD caused by stroke and TBI were 61.8 and 12.5 cases per 100,000 per year respectively, while the overall prevalence was 657 cases per 100,000 people. The SF-36 physical and mental component scores were 28.9 and 44.5 respectively. The total economic burden was calculated to be 382.14 million euro per year, distributed between 215.27 and 166.87 of formal and informal burden respectively. The average cost per individual was 21,040 € per year. Conclusions The main conclusion of this study is that ABD has a high impact in both epidemiological and economic terms as well as loss in quality of life. The overall prevalence obtained is equivalent to 0.7% of the total population. The substantial economic burden is distributed nearly evenly between formal and informal costs. Specifically, it was found that the physical dimensions of quality of life are the most severely affected. The prevalence-based approach showed adequate

  12. Influence of Mobile Phones on the Quality of ECG Signal Acquired by Medical Devices

    NASA Astrophysics Data System (ADS)

    Buczkowski, T.; Janusek, D.; Zavala-Fernandez, H.; Skrok, M.; Kania, M.; Liebert, A.

    2013-10-01

    Health aspects of the use of radiating devices, like mobile phones, are still a public concern. Stand-alone electrocardiographic systems and those built-in, more sophisticated, medical devices have become a standard tool used in everyday medical practice. GSM mobile phones might be a potential source of electromagnetic interference (EMI) which may affect reliability of medical appliances. Risk of such event is particularly high in places remote from GSM base stations in which the signal received by GSM mobile phone is weak. In such locations an increase in power of transmitted radio signal is necessary to enhance quality of the communication. In consequence, the risk of interference of electronic devices increases because of the high level of EMI. In the present paper the spatial, temporal, and spectral characteristics of the interference have been examined. The influence of GSM mobile phone on multilead ECG recordings was studied. It was observed that the electrocardiographic system was vulnerable to the interference generated by the GSM mobile phone working with maximum transmit power and in DTX mode when the device was placed in a distance shorter than 7.5 cm from the ECG electrode located on the surface of the chest. Negligible EMI was encountered at any longer distance.

  13. AIDS. Acquired Immune Deficiency Syndrome Curriculum Planning Guidelines: Elementary, Junior High, High School.

    ERIC Educational Resources Information Center

    Montana State Dept. of Public Instruction, Helena.

    The support materials in this guide provide background and content materials for school personnel and others to modify and use in their education programming on Acquired Immune Deficiency Syndrome (AIDS) for K-12 students. The following support materials are included: (1) the U.S. Surgeon General's report on AIDS; (2) digest and reference guide to…

  14. Improving the quality of radiographic images acquired with conical radiation beams through divergence correction and filtering

    NASA Astrophysics Data System (ADS)

    Silvani, M. I.; Almeida, G. L.; Latini, R. M.; Bellido, A. V. B.; Souza, E. S.; Lopes, R. T.

    2015-07-01

    Earlier works have shown the feasibility to correct the deformation of the attenuation map in radiographs acquired with conical radiation beams provided that the inspected object could be expressed into analytical geometry terms. This correction reduces the contribution of the main object in the radiograph, allowing thus the visualization of its otherwise concealed heterogeneities. However, the non-punctual character of the source demanded a cumbersome trial-and-error approach in order to determine the proper correction parameters for the algorithm. Within this frame, this work addresses the improvement of radiographs of specially tailored test-objects acquired with a conical beam through correction of its divergence by using the information contained in the image itself. The corrected images have afterwards undergone a filtration in the frequency domain aiming at the reduction of statistical fluctuation and noise by using a 2D Fourier transform. All radiographs have been acquired using 165Dy and 198Au gamma-ray sources produced at the Argonauta research reactor in Institutode Engenharia Nuclear - CNEN, and an X-ray sensitive imaging plate as detector. The processed images exhibit features otherwise invisible in the original ones. Their processing by conventional histogram equalization carried out for comparison purposes did not succeed to detect those features.

  15. Safeguarding quality: building the business case to prevent nursing-sensitive hospital-acquired conditions.

    PubMed

    Virkstis, Katherine L; Westheim, Jared; Boston-Fleischhauer, Carol; Matsui, Paul N; Jaggi, Tonushree

    2009-01-01

    In the wake of recent changes by the Centers for Medicare and Medicaid Services to the Inpatient Prospective Payment System and a profoundly weakening economic climate, concern about preventable, hospital-acquired conditions (HACs) has captured the attention of healthcare executives nationwide. Despite the rapidly growing concern about reimbursement at risk, however, data suggest that the greatest financial opportunity for all HACs is to prevent them from happening in the first place. Based on analysis conducted by the Nursing Executive Center's Data and Analytics Group, the authors quantify reimbursement at risk due to HACs and calculate the cost-savings opportunity, building the business case for investment to prevent nursing-sensitive HACs.

  16. High power, high beam quality regenerative amplifier

    DOEpatents

    Hackel, Lloyd A.; Dane, Clifford B.

    1993-01-01

    A regenerative laser amplifier system generates high peak power and high energy per pulse output beams enabling generation of X-rays used in X-ray lithography for manufacturing integrated circuits. The laser amplifier includes a ring shaped optical path with a limited number of components including a polarizer, a passive 90 degree phase rotator, a plurality of mirrors, a relay telescope, and a gain medium, the components being placed close to the image plane of the relay telescope to reduce diffraction or phase perturbations in order to limit high peak intensity spiking. In the ring, the beam makes two passes through the gain medium for each transit of the optical path to increase the amplifier gain to loss ratio. A beam input into the ring makes two passes around the ring, is diverted into an SBS phase conjugator and proceeds out of the SBS phase conjugator back through the ring in an equal but opposite direction for two passes, further reducing phase perturbations. A master oscillator inputs the beam through an isolation cell (Faraday or Pockels) which transmits the beam into the ring without polarization rotation. The isolation cell rotates polarization only in beams proceeding out of the ring to direct the beams out of the amplifier. The diffraction limited quality of the input beam is preserved in the amplifier so that a high power output beam having nearly the same diffraction limited quality is produced.

  17. High power, high beam quality regenerative amplifier

    DOEpatents

    Hackel, L.A.; Dane, C.B.

    1993-08-24

    A regenerative laser amplifier system generates high peak power and high energy per pulse output beams enabling generation of X-rays used in X-ray lithography for manufacturing integrated circuits. The laser amplifier includes a ring shaped optical path with a limited number of components including a polarizer, a passive 90 degree phase rotator, a plurality of mirrors, a relay telescope, and a gain medium, the components being placed close to the image plane of the relay telescope to reduce diffraction or phase perturbations in order to limit high peak intensity spiking. In the ring, the beam makes two passes through the gain medium for each transit of the optical path to increase the amplifier gain to loss ratio. A beam input into the ring makes two passes around the ring, is diverted into an SBS phase conjugator and proceeds out of the SBS phase conjugator back through the ring in an equal but opposite direction for two passes, further reducing phase perturbations. A master oscillator inputs the beam through an isolation cell (Faraday or Pockels) which transmits the beam into the ring without polarization rotation. The isolation cell rotates polarization only in beams proceeding out of the ring to direct the beams out of the amplifier. The diffraction limited quality of the input beam is preserved in the amplifier so that a high power output beam having nearly the same diffraction limited quality is produced.

  18. Ultra-high resolution color images of the surface of comet 67P acquired by ROLIS

    NASA Astrophysics Data System (ADS)

    Schröder, Stefan; Mottola, Stefano; Arnold, Gabriele; Grothues, Hans-Georg; Hamm, Maximilian; Jaumann, Ralf; Michaelis, Harald; Pelivan, Ivanka; Proffe, Gerrit; Bibring, Jean-Pierre

    2015-04-01

    On Nov 12, 2014, the Rosetta Philae lander descended towards comet 67P/Churyumov-Gerasimenko. The onboard ROLIS camera successfully acquired high resolution images of the surface looking down from its vantage point on the instrument platform. ROLIS is a compact CCD imager with a 1024×1024 pixel sensor and a 57° field of view (Mottola et al., 2007, SSR 128, 241). It is equipped with an infinity lens (IFL), without which the camera focus is 30 cm. At Philae's final landing site, ROLIS removed the IFL and initiated an imaging sequence that shows the surface at the highest resolution ever obtained for a cometary surface (~0.5 mm per pixel). Illumination of the scene was provided by an onboard array of LEDs in four different colors: red, green, blue, and near-IR. ROLIS acquired one image for each color and a single dark exposure. The images show a unique, almost fractal morphology for the surface below the landing site that defies easy interpretation. However, there are similarities with some structures seen by the CIVA camera. Color and albedo variations over the surface are minor, and individual grains cannot be distinguished. The images are out-of-focus, indicating the surface was further away than the nominal 30 cm. The location of the illumination spot and the change of focus over the image are consistent with an inclined surface, indicating that Philae's final resting position is strongly tilted. In fact, it was inclined so much that we see the local horizon, even though ROLIS is downward-looking. Remarkably, the scene beyond the horizon is illuminated by the Sun, and out-of-focus particles can be seen to travel in the sky. The images suggest the environment of the lander is laden with fine dust, but a final assessment requires careful consideration of possible sources of stray light. Just before Philae went to sleep, ROLIS acquired an additional exposure with the IFL and the red LED. The resulting image is fully in focus. Because Philae had rotated and lifted

  19. Oral candidiasis in high-risk patients as the initial manifestation of the acquired immunodeficiency syndrome.

    PubMed

    Klein, R S; Harris, C A; Small, C B; Moll, B; Lesser, M; Friedland, G H

    1984-08-09

    We studied the frequency with which unexplained oral candidiasis led to unequivocal acquired immunodeficiency syndrome (AIDS) in patients at risk. Twenty-two previously healthy adults with unexplained oral candidiasis, of whom the 19 tested had a reversed T4/T8 ratio and 20 had generalized lymphadenopathy, were compared with 20 similar patients with a reversed T4/T8 ratio and generalized lymphadenopathy who did not have oral candidiasis. All were intravenous-drug abusers, homosexual or bisexual men, or both. Thirteen of the 22 patients with oral candidiasis (59 per cent) acquired a major opportunistic infection or Kaposi's sarcoma at a median of three months (range, 1 to 23) as compared with none of 20 patients with generalized lymphadenopathy and immunodeficiency but without candidiasis who were followed for a median of 12 months (range, 5 to 21) (P less than 0.001). AIDS developed in 12 of 15 patients with candidiasis and T4/T8 ratios less than or equal to 0.51, as compared with none of four with ratios equal to or greater than 0.60 (P less than 0.01). We conclude that in patients at high risk for AIDS, the presence of unexplained oral candidiasis predicts the development of serious opportunistic infections more than 50 per cent of the time. Whether the remainder will have AIDS is not yet known.

  20. Vibrational spectroscopic studies to acquire a quality control method of Eucalyptus essential oils.

    PubMed

    Baranska, M; Schulz, H; Reitzenstein, S; Uhlemann, U; Strehle, M A; Krüger, H; Quilitzsch, R; Foley, W; Popp, J

    2005-08-05

    This article presents a novel and original approach to analyze in situ the main components of Eucalyptus oil by means of Raman spectroscopy. The obtained two-dimensional Raman maps demonstrate a unique possibility to study the essential oil distribution in the intact plant tissue. Additionally, Fourier Transform (FT)-Raman and attenuated total reflection (ATR)-IR spectra of essential oils isolated from several Eucalyptus species by hydrodistillation are presented. Density Functional Theory (DFT) calculations were performed in order to interpret the spectra of the essential oils of the Eucalyptus species. It is shown that the main components of the essential oils can be recognized by both vibrational spectroscopic techniques using the spectral information of the pure terpenoids. Spectroscopic analysis is based on the key bands of the individual volatile substances and therefore allows one to discriminate different essential oil profiles of several Eucalyptus species. It has been found that the presented spectroscopic data correlate very well with those obtained by gas chromatography (GC) analysis. All these investigations are helpful tools to generate a fast and easy method to control the quality of the essential oils with vibrational spectroscopic techniques in combination with DFT calculations.

  1. A procedure for high resolution satellite imagery quality assessment.

    PubMed

    Crespi, Mattia; De Vendictis, Laura

    2009-01-01

    Data products generated from High Resolution Satellite Imagery (HRSI) are routinely evaluated during the so-called in-orbit test period, in order to verify if their quality fits the desired features and, if necessary, to obtain the image correction parameters to be used at the ground processing center. Nevertheless, it is often useful to have tools to evaluate image quality also at the final user level. Image quality is defined by some parameters, such as the radiometric resolution and its accuracy, represented by the noise level, and the geometric resolution and sharpness, described by the Modulation Transfer Function (MTF). This paper proposes a procedure to evaluate these image quality parameters; the procedure was implemented in a suitable software and tested on high resolution imagery acquired by the QuickBird, WorldView-1 and Cartosat-1 satellites.

  2. A Procedure for High Resolution Satellite Imagery Quality Assessment

    PubMed Central

    Crespi, Mattia; De Vendictis, Laura

    2009-01-01

    Data products generated from High Resolution Satellite Imagery (HRSI) are routinely evaluated during the so-called in-orbit test period, in order to verify if their quality fits the desired features and, if necessary, to obtain the image correction parameters to be used at the ground processing center. Nevertheless, it is often useful to have tools to evaluate image quality also at the final user level. Image quality is defined by some parameters, such as the radiometric resolution and its accuracy, represented by the noise level, and the geometric resolution and sharpness, described by the Modulation Transfer Function (MTF). This paper proposes a procedure to evaluate these image quality parameters; the procedure was implemented in a suitable software and tested on high resolution imagery acquired by the QuickBird, WorldView-1 and Cartosat-1 satellites. PMID:22412312

  3. Blood donors at high risk of transmitting the acquired immune deficiency syndrome.

    PubMed

    Contreras, M; Hewitt, P E; Barbara, J A; Mochnaty, P Z

    1985-03-09

    The acquired immune deficiency syndrome (AIDS) occurs most commonly in homosexual men. This group carries the greatest risk of transmitting AIDS by blood transfusion. Both promiscuous and nonpromiscuous male homosexuals should refrain from giving blood. A leaflet stating this advice was prepared by the Department of Health and Social Security, United Kingdom. In July 1984 a questionnaire was given to all donors attending a blood donor clinic in the west end of London, England. 53% were male. Donors were given a leaflet on AIDS and a questionnaire to complete in private. Those who considered themselves to be in a high risk group were asked to designate their blood for research purposes only. Serum samples from donors who confirmed that they were in the high risk category were tested for antihepatitis B core antigen and anti-human T lymphotropic virus type III (anti-HTLV-III) in addition to the routine screening of donors for hepatitis B surface antigen and syphilis. All high risk donors were men. Homosexuality was the only high risk factor. Of 5000 questionnaires administered between July and October, 614 were not completed or had ambiguous answers. 38 donors who completed the questionnaire beonged to a high risk group. Of these, 7 were positive for antihepatitis B core antigen; none were positive for anti-HTLV-III, T pallidum hemagglatination, or hepatits B surface antigen. Although the homosexual donors had a much lower incidence of sexually transmitted disease than those attending special clinics, this should not encourage complacency. All possible measures must be taken to prevent homosexuals from donating blood.

  4. Acquired immunodeficiency syndrome-related malignancies in the era of highly active antiretroviral therapy.

    PubMed

    Bernstein, Wendy B; Little, Richard F; Wilson, Wyndham H; Yarchoan, Robert

    2006-07-01

    Since the beginning of the acquired immunodeficiency syndrome (AIDS) epidemic, malignancies have been an important feature of this disease. Several cancers, including Kaposi sarcoma (KS), certain aggressive B-cell lymphomas, and cervical cancer, are considered AIDS-defining when they occur in patients infected with human immunodeficiency virus. Most AIDS-defining tumors are associated with one of 3 DNA viruses: KS-associated herpesvirus, Epstein-Barr virus, or human papillomavirus. With the introduction of highly active antiretroviral therapy (HAART), the incidence of KS and certain lymphomas has decreased, whereas that of other tumors, such as cervical cancer, has undergone little change. Several new drugs and therapies have been developed for KS and AIDS-related lymphomas, and these treatments, plus the development of HAART, have contributed to improvements in morbidity and mortality. At the same time, the improved overall survival of patients with HAART has contributed to an increase in the number of patients living with AIDS in developed countries such as the United States. With the development of HAART and improved prevention and treatment of opportunistic infections, an increasing percentage of the deaths in AIDS patients have been from malignancies. Strategies for prevention, screening, and therapy remain important areas of research in this developing field.

  5. Excellence through High-Quality Individualization.

    ERIC Educational Resources Information Center

    Burns, Richard W.; Klingstedt, Joe Lars

    1988-01-01

    Proposes a strategy employing challenge, functionalism, high-order learning, and originality to achieve high-quality individualization in course work. Asserts that individualized instruction better prepares students to solve problems, make decisions, and produce original ideas. (MM)

  6. An evaluation of SEBAL algorithm using high resolution aircraft data acquired during BEAREX07

    NASA Astrophysics Data System (ADS)

    Paul, G.; Gowda, P. H.; Prasad, V. P.; Howell, T. A.; Staggenborg, S.

    2010-12-01

    Surface Energy Balance Algorithm for Land (SEBAL) computes spatially distributed surface energy fluxes and evapotranspiration (ET) rates using a combination of empirical and deterministic equations executed in a strictly hierarchical sequence. Over the past decade SEBAL has been tested over various regions and has found its application in solving water resources and irrigation problems. This research combines high resolution remote sensing data and field measurements of the surface radiation and agro-meteorological variables to review various SEBAL steps for mapping ET in the Texas High Plains (THP). High resolution aircraft images (0.5-1.8 m) acquired during the Bushland Evapotranspiration and Agricultural Remote Sensing Experiment 2007 (BEAREX07) conducted at the USDA-ARS Conservation and Production Research Laboratory in Bushland, Texas, was utilized to evaluate the SEBAL. Accuracy of individual relationships and predicted ET were investigated using observed hourly ET rates from 4 large weighing lysimeters, each located at the center of 4.7 ha field. The uniqueness and the strength of this study come from the fact that it evaluates the SEBAL for irrigated and dryland conditions simultaneously with each lysimeter field planted to irrigated forage sorghum, irrigated forage corn, dryland clumped grain sorghum, and dryland row sorghum. Improved coefficients for the local conditions were developed for the computation of roughness length for momentum transport. The decision involved in selection of dry and wet pixels, which essentially determines the partitioning of the available energy between sensible (H) and latent (LE) heat fluxes has been discussed. The difference in roughness length referred to as the kB-1 parameter was modified in the current study. Performance of the SEBAL was evaluated using mean bias error (MBE) and root mean square error (RMSE). An RMSE of ±37.68 W m-2 and ±0.11 mm h-1 was observed for the net radiation and hourly actual ET, respectively

  7. Assuring quality in high-consequence engineering

    SciTech Connect

    Hoover, Marcey L.; Kolb, Rachel R.

    2014-03-01

    In high-consequence engineering organizations, such as Sandia, quality assurance may be heavily dependent on staff competency. Competency-dependent quality assurance models are at risk when the environment changes, as it has with increasing attrition rates, budget and schedule cuts, and competing program priorities. Risks in Sandia's competency-dependent culture can be mitigated through changes to hiring, training, and customer engagement approaches to manage people, partners, and products. Sandia's technical quality engineering organization has been able to mitigate corporate-level risks by driving changes that benefit all departments, and in doing so has assured Sandia's commitment to excellence in high-consequence engineering and national service.

  8. Selecting, Acquiring, and Using Small Molecule Libraries for High-Throughput Screening.

    PubMed

    Dandapani, Sivaraman; Rosse, Gerard; Southall, Noel; Salvino, Joseph M; Thomas, Craig J

    The selection, acquisition and use of high quality small molecule libraries for screening is an essential aspect of drug discovery and chemical biology programs. Screening libraries continue to evolve as researchers gain a greater appreciation of the suitability of small molecules for specific biological targets, processes and environments. The decisions surrounding the make-up of any given small molecule library is informed by a multitude of variables and opinions vary on best-practices. The fitness of any collection relies upon upfront filtering to avoiding problematic compounds, assess appropriate physicochemical properties, install the ideal level of structural uniqueness and determine the desired extent of molecular complexity. These criteria are under constant evaluation and revision as academic and industrial organizations seek out collections that yield ever improving results from their screening portfolios. Practical questions including cost, compound management, screening sophistication and assay objective also play a significant role in the choice of library composition. This overview attempts to offer advice to all organizations engaged in small molecule screening based upon current best practices and theoretical considerations in library selection and acquisition.

  9. Making Hospitals Safer for Older Adults: Updating Quality Metrics by Understanding Hospital-Acquired Delirium and Its Link to Falls

    PubMed Central

    Lee, Eric A; Gibbs, Nancy E; Fahey, Linda; Whiffen, Teri L

    2013-01-01

    The medical care of hospitalized geriatric patients must differ from the care of younger adults. Because of reduced “reserve capacity,” hospitalized older adults are at high risk of development of geriatric syndromes such as delirium and falls. Geriatric syndromes often lead to functional decline and dependence. Patients who experience geriatric syndromes in the hospital are more likely to have a longer length of stay, higher risk of readmissions, and worse medical outcomes. Incident delirium in hospitalized geriatric patients has been shown to be preventable by intervening in established risk factors. Prevention of hospital-related falls has not been consistently demonstrated. Analysis from Kaiser Permanente data demonstrated a correlation with delirium and hospital-related falls. We propose that age-specific quality metrics should be made to reduce the risk of the development of geriatric syndromes in hospitalized older adults. By preventing delirium, we believe that health care practitioners can reduce hospital-related falls in geriatric patients and improve the quality of care delivered to hospitalized older adults. An illustrative fictional case study is presented. PMID:24361018

  10. Analysis of the quality of image data acquired by the LANDSAT-4 thematic mapper and multispectral scanners. [Plumas County, California

    NASA Technical Reports Server (NTRS)

    Colwell, R. N. (Principal Investigator)

    1984-01-01

    A seven step procedure developed for evaluating the geometric properties of MSS and TM film produces is being implemented. Some 476 control points were selected of which 238 are being tested and edited for digitization and scaling errors. Tables show statistics established for assessing the spectral characteristics and variability, as well as the spatial resolution and radiometric sensitivity of TM data for a forest environment in an effort to determine the extent to which major forest cover type can be detected and identified on TM digital and image products. Results thus far show that the high quality obtained are more than sufficient for meeting most of the inventory objectives of the renewable resource specialist. The TM data should be extremely valuable for: (1) estimating forest cover types; (2) updating land use survey maps; and (3) determining the size and shape and location of individual forest clearings and water resources.

  11. A Prospective, Descriptive, Quality Improvement Study to Decrease Incontinence-Associated Dermatitis and Hospital-Acquired Pressure Ulcers.

    PubMed

    Hall, Kimberly D; Clark, Rebecca C

    2015-07-01

    Incontinence is a common problem among hospitalized patients and has been associated with multiple health complications, including incontinence-associated dermatitis (IAD) and hospital-acquired pressure ulcers (HAPUs). A prospective, descriptive study was conducted in 2 acute care neurology units to 1) assess the prevalence of incontinence and incidence of IAD and HAPUs among incontinent patients, and 2) evaluate the effect of caregiver education and use of a 1-step cleanser, moisturizer, barrier product on the development of IAD and HAPUs among patients with incontinence. During a period of 1 month, the incontinence status of admitted patients was recorded and skin was assessed for the presence/absence of IAD and HAPUs twice per day. After the 1-month data collection, all clinicians on the study units completed a facility-based online education program about IAD, HAPUs, and skin care followed by the implementation of a 1-step cleanser/barrier product for skin care of all patients with incontinence. Data collection procedures remained the same. Data were collected using a paper/pencil instrument and entered into a spreadsheet for analysis. Descriptive statistics were calculated and prevalence and incidence rates were compared between the pre-intervention and post-intervention phase using Fisher's exact analysis. During the first phase of the study, 17 of 40 admitted patients (42.5%) were incontinent. Of those, 5 (29.4%) developed IAD and all of these patients developed HAPUs (5 of 40 admitted, 29.4%) during an average length of stay of 7.3 (range: 2-14) days. In the intervention phase of the study, 25 of 46 (54.3%) patients were incontinent and none developed IAD or a HAPU during an average length of stay of 7.4 (range: 2-14) days. The average Braden scale score was 14.14 in the pre-intervention group of patients with incontinence and 12.74 in the intervention group. The prevalence of incontinence among patients admitted to acute care neurology units and the rate

  12. Analysis of the quality of image data acquired by the LANDSAT-4 thematic mapper and multispectral scanners

    NASA Technical Reports Server (NTRS)

    Colwell, R. N. (Principal Investigator)

    1983-01-01

    The geometric quality of the TM and MSS film products were evaluated by making selective photo measurements such as scale, linear and area determinations; and by measuring the coordinates of known features on both the film products and map products and then relating these paired observations using a standard linear least squares regression approach. Quantitative interpretation tests are described which evaluate the quality and utility of the TM film products and various band combinations for detecting and identifying important forest and agricultural features.

  13. [Fatal lactic acidosis in a patient with acquired immunodeficiency syndrome treated with highly active antiretroviral therapy. Report of a case].

    PubMed

    Lasso, M; Pérez, J; Noriega, L M; Northland, R

    2000-10-01

    Type B lactic acidosis occurs without any evidence of cellular hypoxia and is associated with the use of drugs or toxins. We report a 36 years old woman with acquired immunodeficiency syndrome that was admitted to the hospital with a severe lactic acidosis. She had been treated with didanosine, stavudine and efavirenz for four months prior to admission. Despite the use of high bicarbonate doses and vasoactive drugs, the patient had a catastrophic evolution and died in shock and multiple organ failure, 68 hours after admission. (Rev Méd Chile 2000; 128: 1139-43).

  14. Decreased sleep quality in high myopia children

    PubMed Central

    Ayaki, Masahiko; Torii, Hidemasa; Tsubota, Kazuo; Negishi, Kazuno

    2016-01-01

    The aim of the present study was to evaluate sleep quality in myopic children and adults. This cross sectional study surveyed 486 participants aged from 10 to 59 years with refractive errors using a questionnaire containing the Pittsburgh Sleep Quality Index (PSQI) and Hospital Anxiety and Depression Scale (HADS). Children (< 20 years) in the high myopia group exhibited the poorest PSQI scores (P < 0.01), while the adults showed no such correlations. Subscales of PSQI and HADS in children disclosed that the high myopia groups had the shortest sleep duration (P < 0.01), worst subjective sleep scores (P < 0.001), and latest bedtime (P < 0.05). Regression analyses in children significantly correlated myopic errors with PSQI (P < 0.05), sleep duration (P < 0.01), and bedtime (P < 0.01). Sleep efficacy (P < 0.05) and daytime dysfunction (P < 0.05) were significantly better in contact-lens users compared to the respective non-user groups across all participants. In conclusion, sleep quality in children was significantly correlated with myopic error, with the high myopia group worst affected. PMID:27650408

  15. Acquired hyperpigmentations*

    PubMed Central

    Cestari, Tania Ferreira; Dantas, Lia Pinheiro; Boza, Juliana Catucci

    2014-01-01

    Cutaneous hyperpigmentations are frequent complaints, motivating around 8.5% of all dermatological consultations in our country. They can be congenital, with different patterns of inheritance, or acquired in consequence of skin problems, systemic diseases or secondary to environmental factors. The vast majority of them are linked to alterations on the pigment melanin, induced by different mechanisms. This review will focus on the major acquired hyperpigmentations associated with increased melanin, reviewing their mechanisms of action and possible preventive measures. Particularly prominent aspects of diagnosis and therapy will be emphasized, with focus on melasma, post-inflammatory hyperpigmentation, periorbital pigmentation, dermatosis papulosa nigra, phytophotodermatoses, flagellate dermatosis, erythema dyschromicum perstans, cervical poikiloderma (Poikiloderma of Civatte), acanthosis nigricans, cutaneous amyloidosis and reticulated confluent dermatitis PMID:24626644

  16. High quality factor indium oxide mechanical microresonators

    SciTech Connect

    Bartolomé, Javier Cremades, Ana; Piqueras, Javier

    2015-11-09

    The mechanical resonance behavior of as-grown In{sub 2}O{sub 3} microrods has been studied in this work by in-situ scanning electron microscopy (SEM) electrically induced mechanical oscillations. Indium oxide microrods grown by a vapor–solid method are naturally clamped to an aluminum oxide ceramic substrate, showing a high quality factor due to reduced energy losses during mechanical vibrations. Quality factors of more than 10{sup 5} and minimum detectable forces of the order of 10{sup −16} N/Hz{sup 1/2} demonstrate their potential as mechanical microresonators for real applications. Measurements at low-vacuum using the SEM environmental operation mode were performed to study the effect of extrinsic damping on the resonators behavior. The damping coefficient has been determined as a function of pressure.

  17. Genetic Predisposition To Acquire a Polybasic Cleavage Site for Highly Pathogenic Avian Influenza Virus Hemagglutinin.

    PubMed

    Nao, Naganori; Yamagishi, Junya; Miyamoto, Hiroko; Igarashi, Manabu; Manzoor, Rashid; Ohnuma, Aiko; Tsuda, Yoshimi; Furuyama, Wakako; Shigeno, Asako; Kajihara, Masahiro; Kishida, Noriko; Yoshida, Reiko; Takada, Ayato

    2017-02-14

    Highly pathogenic avian influenza viruses with H5 and H7 hemagglutinin (HA) subtypes evolve from low-pathogenic precursors through the acquisition of multiple basic amino acid residues at the HA cleavage site. Although this mechanism has been observed to occur naturally only in these HA subtypes, little is known about the genetic basis for the acquisition of the polybasic HA cleavage site. Here we show that consecutive adenine residues and a stem-loop structure, which are frequently found in the viral RNA region encoding amino acids around the cleavage site of low-pathogenic H5 and H7 viruses isolated from waterfowl reservoirs, are important for nucleotide insertions into this RNA region. A reporter assay to detect nontemplated nucleotide insertions and deep-sequencing analysis of viral RNAs revealed that an increased number of adenine residues and enlarged stem-loop structure in the RNA region accelerated the multiple adenine and/or guanine insertions required to create codons for basic amino acids. Interestingly, nucleotide insertions associated with the HA cleavage site motif were not observed principally in the viral RNA of other subtypes tested (H1, H2, H3, and H4). Our findings suggest that the RNA editing-like activity is the key mechanism for nucleotide insertions, providing a clue as to why the acquisition of the polybasic HA cleavage site is restricted to the particular HA subtypes.IMPORTANCE Influenza A viruses are divided into subtypes based on the antigenicity of the viral surface glycoproteins hemagglutinin (HA) and neuraminidase. Of the 16 HA subtypes (H1 to -16) maintained in waterfowl reservoirs of influenza A viruses, H5 and H7 viruses often become highly pathogenic through the acquisition of multiple basic amino acid residues at the HA cleavage site. Although this mechanism has been known since the 1980s, the genetic basis for nucleotide insertions has remained unclear. This study shows the potential role of the viral RNA secondary structure for

  18. Rats acquire stronger preference for flavors consumed towards the end of a high-fat meal.

    PubMed

    Myers, Kevin P

    2013-02-17

    Rats learn to prefer flavors associated with postingestive effects of nutrients. The physiological signals underlying this postingestive reward are unknown. We have previously shown that rats readily learn to prefer a flavor that was consumed early in a multi-flavored meal when glucose is infused intragastrically (IG), suggesting rapid postingestive reward onset. The present experiments investigate the timing of postingestive fat reward, by providing distinctive flavors in the first and second halves of meals accompanied by IG fat infusion. Learning stronger preference for the earlier or later flavor would indicate when the rewarding postingestive effects are sensed. Rats consumed sweetened, calorically-dilute flavored solutions accompanied by IG high-fat infusion (+ sessions) or water (- sessions). Each session included an "Early" flavor for 8min followed by a "Late" flavor for 8min. Learned preferences were then assessed in two-bottle tests (no IG infusion) between Early(+) vs. Early(-), Late(+) vs. Late(-), Early(+) vs. Late(+), and Early(-) vs. Late(-). Rats only preferred Late(+), not Early(+), relative to their respective (-) flavors. In a second experiment rats trained with a higher fat concentration learned to prefer Early(+) but more strongly preferred Late(+). Learned preferences were evident when rats were tested deprived or recently satiated. Unlike with glucose, ingested fat appears to produce a slower-onset rewarding signal, detected later in a meal or after its termination, becoming more strongly associated with flavors towards the end of the meal. This potentially contributes to enhanced liking for dessert foods, which persists even when satiated.

  19. Genetic Predisposition To Acquire a Polybasic Cleavage Site for Highly Pathogenic Avian Influenza Virus Hemagglutinin

    PubMed Central

    Nao, Naganori; Yamagishi, Junya; Miyamoto, Hiroko; Igarashi, Manabu; Manzoor, Rashid; Ohnuma, Aiko; Tsuda, Yoshimi; Furuyama, Wakako; Shigeno, Asako; Kajihara, Masahiro; Kishida, Noriko; Yoshida, Reiko

    2017-01-01

    ABSTRACT Highly pathogenic avian influenza viruses with H5 and H7 hemagglutinin (HA) subtypes evolve from low-pathogenic precursors through the acquisition of multiple basic amino acid residues at the HA cleavage site. Although this mechanism has been observed to occur naturally only in these HA subtypes, little is known about the genetic basis for the acquisition of the polybasic HA cleavage site. Here we show that consecutive adenine residues and a stem-loop structure, which are frequently found in the viral RNA region encoding amino acids around the cleavage site of low-pathogenic H5 and H7 viruses isolated from waterfowl reservoirs, are important for nucleotide insertions into this RNA region. A reporter assay to detect nontemplated nucleotide insertions and deep-sequencing analysis of viral RNAs revealed that an increased number of adenine residues and enlarged stem-loop structure in the RNA region accelerated the multiple adenine and/or guanine insertions required to create codons for basic amino acids. Interestingly, nucleotide insertions associated with the HA cleavage site motif were not observed principally in the viral RNA of other subtypes tested (H1, H2, H3, and H4). Our findings suggest that the RNA editing-like activity is the key mechanism for nucleotide insertions, providing a clue as to why the acquisition of the polybasic HA cleavage site is restricted to the particular HA subtypes. PMID:28196963

  20. Analysis of the quality of image data acquired by the LANDSAT-4 thematic mapper and multispectral scanners. [Central Valley, California

    NASA Technical Reports Server (NTRS)

    Colwell, R. N. (Principal Investigator)

    1983-01-01

    Image products and numeric data were extracted from both TM and MSS data in an effort to evaluate the quality of these data for interpreting major agricultural resources and conditions in California's Central Valley. The utility of TM data appears excellent for meeting most of the inventory objectives of the agricultural resource specialist. These data should be extremely valuable for crop type and area proportion estimation, for updating agricultural land use survey maps at 1:24,000-scale and smaller, for field boundary definition, and for determining the size and location of individual farmsteads.

  1. Salvage therapy with high dose Intravenous Immunoglobulins in acquired Von Willebrand Syndrome and unresponsive severe intestinal bleeding

    PubMed Central

    2014-01-01

    A 91-year-old woman affected with acquired Von Willebrand (VW) syndrome and intestinal angiodysplasias presented with severe gastrointestinal bleeding (hemoglobin 5 g/dl). Despite replacement therapy with VW factor/factor VIII concentrate qid, bleeding did not stop (eleven packed red blood cell units were transfused over three days). High circulating levels of anti-VW factor immunoglobulin M were documented immunoenzimatically. Heart ultrasound showed abnormalities of the mitral and aortic valves with severe flow alterations. When intravenous immunoglobulins were added to therapy, prompt clinical and laboratory responses occurred: complete cessation of bleeding, raise in hemoglobin, VW factor antigen, VW ristocetin cofactor and factor VIII levels as well as progressive reduction of the anti-VWF autoantibody levels. PMID:24926417

  2. Analysis of the quality of image data acquired by the LANDSAT-4 Thematic Mapper and Multispectral Scanners

    NASA Technical Reports Server (NTRS)

    Colwell, R. N. (Principal Investigator)

    1984-01-01

    The geometric quality of TM film and digital products is evaluated by making selective photomeasurements and by measuring the coordinates of known features on both the TM products and map products. These paired observations are related using a standard linear least squares regression approach. Using regression equations and coefficients developed from 225 (TM film product) and 20 (TM digital product) control points, map coordinates of test points are predicted. The residual error vectors and analysis of variance (ANOVA) were performed on the east and north residual using nine image segments (blocks) as treatments. Based on the root mean square error of the 223 (TM film product) and 22 (TM digital product) test points, users of TM data expect the planimetric accuracy of mapped points to be within 91 meters and within 117 meters for the film products, and to be within 12 meters and within 14 meters for the digital products.

  3. [Investigation of nasal carriage of community-acquired methicillin resistant Staphylococcus aureus in primary and high school students].

    PubMed

    Ozgüven, Atalay; Tünger, Ozlem; Cetin, Ciğdem Banu; Dinç, Gönül

    2008-10-01

    The aim of this study was to evaluate the carriage rate and risk factors of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) among the students in Manisa, Turkey. A total of 2015 students (1012 from the last phase of high schools and 1003 from the first phase of primary schools) were included in the study. None of the students had nasal MRSA carriage. Methicillin-sensitive S. aureus (MSSA) colonization rate was 14.7% (296/2015). Nasal carriage of MSSA was significantly higher in the primary school students (17.8%) than the high school students (11.6%) (p < 0.001). MSSA carriage was also higher in students of higher socioeconomical status than the students of lower status (p < 0.05). A statistically significant relationship was not determined between the nasal carriage and the risk factors (history of hospitalisation or surgical operation in the previous one year, use of antibiotics or history of skin/soft tissue infection in the last 6 months, presence of children < 15-years-old in the family, presence of healthcare workers in the same house, living in a crowded house). Penicillin and erythromycin resistance was found in 93.6% and 14.2% of MSSA strains, respectively. No resistance was detected against ciprofloxacin, co-trimoxazole, linezolid and vancomycin. There was a statistically significant difference between erythromycin resistance and antibiotic use within the last six months and the number of family members (p < 0.05). In conclusion, current treatment regimens still seem to be affective and safe for the empirical treatment of community-acquired S. aureus infections. Although CA-MRSA infections seem not to be a serious threat in our region yet, it is essential to carry out prevalence studies in the different populations of the community.

  4. [Quality management is associated with high quality services in health care].

    PubMed

    Nielsen, Tenna Hassert; Riis, Allan; Mainz, Jan; Jensen, Anne-Louise Degn

    2013-12-09

    In these years, quality management has been the focus in order to meet high quality services for the patients in Danish health care. This article provides information on quality management and quality improvement and it evaluates its effectiveness in achieving better organizational structures, processes and results in Danish health-care organizations. Our findings generally support that quality management is associated with high quality services in health care.

  5. High-resolution chirp seismic reflection data acquired from the Cap de Creus shelf and canyon area, Gulf of Lions, Spain in 2004

    USGS Publications Warehouse

    Grossman, Eric E.; Hart, Patrick E.; Field, Michael E.; Triezenberg, Peter

    2006-01-01

    Seismic reflection data were collected from the Cap de Creus shelf and canyon in the southwest portion of the Gulf of Lions in October 2004. The data were acquired using the U.S. Geological Survey`s (USGS) high-resolution Edgetech CHIRP 512i seismic reflection system aboard the R/V Oceanus. Data from the shipboard 3.5 kHz echosounder were also collected but are not presented here. The seismic reflection data were collected as part of EuroSTRATAFORM funded by the Office of Naval Research. In October 2004, more than 200 km of high resolution seismic reflection data were collected in water depths ranging 30 m - 600 m. All data were recorded with a Delph Seismic PC-based digital recording system and processed with Delph Seismic software. Processed sections were georeferenced into tiff images for digital archive, processing and display. Penetration ranged 20-80 m. The data feature high quality vertical cross-section imagery of numerous sequences of Quaternary seismic stratigraphy. The report includes trackline maps showing the location of the data, as well as both digital data files (SEG-Y) and images of all of the profiles. The data are of high quality and provide new information on the location and thickness of sediment deposits overlying a major erosion surface on the Cap de Creus shelf; they also provide new insight into sediment processes on the walls and in the channel of Cap de Creus Canyon. These data are under study by researchers at the US Geological Survey, the University of Barcelona, and Texas A and M University. Copies of the data are available to all researchers.

  6. Swell effect correction for the high-resolution marine seismic data acquired using an airgun and an 8-channel streamer cable

    NASA Astrophysics Data System (ADS)

    Lee, Ho-Young; Koo, Nam-Hyung; Kim, Wonsik; Kim, Byoung-yeop; Cheong, Snons; Kim, Young-Jun

    2015-04-01

    High-resolution marine seismic surveys are used for the imaging of the detailed subsurface geological structure in engineering and marine geological survey. When the sea state gets worse, the quality of the seismic data become worse due to the sea swell. We corrected the swell effect to enhance the quality of seismic data. To remove the swell effect, we picked the sea bottom location automatically, averaged the picked sea bottom times of the adjacent traces and corrected the differences between the calculated and averaged sea bottom location. To make high quality seismic section, we used high-resolution marine 8-channel airgun seismic data acquired off Yeosu, Korea. The energy source was a 30 in3 airgun and the receiver was a 40 m long 8 channel streamer cable with a group interval of 5 m. The offset distance between the source and the first channel was 20 m. The shot interval was 2 seconds corresponding to ~5 m in distance, assuming ship's speed 5 knots. The data were digitally recorded with a sample interval of 0.1 ms and a record length of 1 s. The processing sequence includes basic processing procedures such as gain recovery, deconvolution, frequency filtering, CMP sorting, NMO correction, swell effect correction and stacking. To select sea bottom location for the swell effect correction, we pick maximum amplitude within the expected range including sea bottom location and find the first location at which the amplitude is larger than the threshold that is 40% of the maximum amplitude. We averaged these two-way travel times of sea bottom and corrected the differences. The range of the swell effect correction was -0.5 ~ 0.4 ms. After correction the continuity of reflectors were improved and high quality of the seismic data was produced. This study is a part of a Basic Research Project of the Korea Institute of Geoscience and Mineral Resources (KIGAM), a National Research Laboratory (NRL) project supported by the Ministry of Science and Technology (MOST), and

  7. Planetary Boundary Layer (PBL) Heights Derived From NASA Langley Airborne High Spectral Resolution Lidar (HSRL) Data Acquired During TexAQS/GoMACCS, CHAPS, and MILAGRO

    NASA Astrophysics Data System (ADS)

    Burton, S. P.; Ferrare, R. A.; Hostetler, C. A.; Hair, J. W.; Cook, A.; Harper, D.; Obland, M. D.; Rogers, R. R.

    2007-12-01

    The NASA Langley Research Center airborne High Spectral Resolution Lidar (HSRL) was deployed on the NASA Langley B-200 King Air aircraft in the Mexico City metropolitan area during the Mega-city Initiative: Local and Global Research Observations (MILAGRO) campaign in March 2006; in the Houston metropolitan area during the Texas Air Quality Study (TexAQS)/Gulf of Mexico Atmospheric Composition and Climate Study (GoMACCS) in August and September 2006; and in the Oklahoma City area during Cumulus Humilis Aerosol Processing Study (CHAPS) in June 2007. The HSRL instrument measures profiles of aerosol extinction, backscatter and depolarization. The height of the Planetary Boundary Layer was derived by identifying sharp gradients in the HSRL 532-nm aerosol backscatter signal profiles using an automated technique based on Brooks (2003) [I.M. Brooks, Finding Boundary Layer Top: Application of Wavelet Covariance Transform to Lidar Backscatter Profiles. Journal of Atmospheric and Oceanic Technology 20, 1092-1105, 2003]. The technique uses a Haar wavelet covariance transform with multiple wavelet dilation values to adapt to non-ideal conditions where there can be gradients in the background signals and the boundary layer can be ill defined. The technique also identifies the top and bottom of the transition (i.e. entrainment) zone. We have further modified the algorithm to find PBL heights using HSRL backscatter data acquired during GoMACCS and MILAGRO, where complex terrain and overlying aerosol layers further complicate identifying the boundary layer. In addition, PBL heights are derived from HSRL backscatter data acquired during the CHAPS campaign, in another urban environment where the terrain is not as complex. We will describe the algorithm modifications we have made and show boundary layer heights and transition zone thicknesses for HSRL measurements over the Oklahoma City, Houston, and Mexico City areas during CHAPS, TexAQS/GoMACCS, and MILAGRO.

  8. Method for synthesis of high quality graphene

    DOEpatents

    Lanzara, Alessandra [Piedmont, CA; Schmid, Andreas K [Berkeley, CA; Yu, Xiaozhu [Berkeley, CA; Hwang, Choonkyu [Albany, CA; Kohl, Annemarie [Beneditkbeuern, DE; Jozwiak, Chris M [Oakland, CA

    2012-03-27

    A method is described herein for the providing of high quality graphene layers on silicon carbide wafers in a thermal process. With two wafers facing each other in close proximity, in a first vacuum heating stage, while maintained at a vacuum of around 10.sup.-6 Torr, the wafer temperature is raised to about 1500.degree. C., whereby silicon evaporates from the wafer leaving a carbon rich surface, the evaporated silicon trapped in the gap between the wafers, such that the higher vapor pressure of silicon above each of the wafers suppresses further silicon evaporation. As the temperature of the wafers is raised to about 1530.degree. C. or more, the carbon atoms self assemble themselves into graphene.

  9. Schistosoma mansoni: is acquired immunity induced by highly x-irradiated cercariae dependent on the size of the challenging dose

    SciTech Connect

    Hsue, S.Y.; Hsue, H.F.; Osborne, J.W.; Johnson, S.C.

    1982-04-01

    A high degree of immunity, as shown by a 91% reduction of the number of worms recovered was found in five groups of mice that were immunized five times with highly X-irradiated cercariae and then challenged with 10, 20, 50, 100, or 500 normal Schistosoma mansoni cercariae. The results indicated that there were no significant differences in worm reduction in immunized mice challenged with different numbers of cercariae; consequently the immunity induced by this immunization method did not appear to be challenge-dose-dependent. However, the results also showed that when immunized mice were challenged with 500, 100, 50, 20, and 10 cercariae, 0, 13, 26, 56, and 68%, respectively, of the experimental animals were free of worms. Thus, the percentage of worm-negative cases increased as the number of challenge cercariae decreased. When viewed in this manner, the acquired immunity may be considered challenge-dose-dependent as well. If this method of vaccination is used for schistosomiasis control, we may anticipate that in both hypo- and hyperendemic areas, the intensity of infection and the severity of the disease will be reduced owing to a reduction in worms burdens, and in hypoendemic areas, there will be a number of worm-free cases.

  10. External scintigraphy in monitoring the behavior of pharmaceutical formulations in vivo I: technique for acquiring high-resolution images of tablets

    SciTech Connect

    Theodorakis, M.C.; Simpson, D.R.; Leung, D.M.; Devous, M. Sr.

    1983-02-01

    A new method for monitoring tablet disintegration in vivo was developed. In this method, the tablets were labeled with a short-lived radionuclide, technetium 99m, and monitored by a gamma camera. Several innovations were introduced with this method. First, computer reconstruction algorithms were used to enhance the scintigraphic images of the disintegrating tablet in vivo. Second, the use of a four-pinhole collimator to acquire multiple views of the tablet resulted in high count rates and reduced acquisition times of the scintigraphic images. Third, the magnification of the scintigraphic images achieved by pinhole collimation led to significant improvement in resolution. Fourth, the radioinuclide was incorporated into the granulation so that the whole mass of the tablet was uniformly labeled with high levels of activity. This technique allowed the continuous monitoring of the disintegration process of tablets in vivo in experimental animals. Multiple pinhole collimation and the labeling process permitted the acquisition of quality scintigraphic images of the labeled tablet every 30 sec. The resolution of the method was tested in vitro and in vivo.

  11. Peer-to-peer nursing rounds and hospital-acquired pressure ulcer prevalence in a surgical intensive care unit: a quality improvement project.

    PubMed

    Kelleher, Alyson Dare; Moorer, Amanda; Makic, MaryBeth Flynn

    2012-01-01

    We conducted a quality improvement project in order to evaluate the effect of nurse-to-nurse bedside "rounding" as a strategy to decrease hospital-acquired pressure ulcers (HAPU) in a surgical intensive care unit. We instituted weekly peer-to-peer bedside skin rounds in a 17-bed surgical intensive care unit. Two nurses were identified as skin champions and trained by the hospital's certified WOC nurse to conduct skin rounds. The skin champion nurses conducted weekly peer-to-peer rounds that included discussions about key elements of our patients' skin status including current Braden Scale for Pressure Sore Risk score, and implementation of specific interventions related to subscale risk assessment. If a pressure ulcer was present, the current action plan was reevaluated for effectiveness. Quarterly HAPU prevalence studies were conducted from January 2008 to December 2010. Nineteen patients experienced a HAPU: 17 were located on the coccyx and 2 on the heel. Ten ulcers were classified as stage II, 3 PU were stage IV, 5 were deemed unstageable, and 1 was classified as a deep tissue injury. The frequency of preventive interventions rose during our quality improvement project. Specifically, the use of prevention surfaces increased 92%, repositioning increased 30%, nutrition interventions increased 77%, and moisture management increased 100%. Prior to focused nursing rounds, the highest HAPU prevalence rate was 27%. After implementing focused nursing rounds, HAPU rates trended down and were 0% for 3 consecutive quarters.

  12. Brush and spray: a high-throughput systemic acquired resistance assay suitable for large-scale genetic screening.

    PubMed

    Jing, Beibei; Xu, Shaohua; Xu, Mo; Li, Yan; Li, Shuxin; Ding, Jinmei; Zhang, Yuelin

    2011-11-01

    Systemic acquired resistance (SAR) is a defense mechanism induced in the distal parts of plants after primary infection. It confers long-lasting protection against a broad spectrum of microbial pathogens. Lack of high-throughput assays has hampered the forward genetic analysis of SAR. Here, we report the development of an easy and efficient assay for SAR and its application in a forward genetic screen for SAR-deficient mutants in Arabidopsis (Arabidopsis thaliana). Using the new assay for SAR, we identified six flavin-dependent monooxygenase1, four AGD2-like defense response protein1, three salicylic acid induction-deficient2, one phytoalexin deficient4, and one avrPphB-susceptible3 alleles as well as a gain-of-function mutant of CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR3 designated camta3-3D. Like transgenic plants overexpressing CAMTA3, camta3-3D mutant plants exhibit compromised SAR and enhanced susceptibility to virulent pathogens, suggesting that CAMTA3 is a critical regulator of both basal resistance and SAR.

  13. High rate of mutation K103N causing resistance to nevirapine in Indian children with acquired immunodeficiency syndrome.

    PubMed

    Sehgal, S; Pasricha, N; Singh, S

    2008-01-01

    In north India the number of paediatric cases with acquired immunodeficiency syndrome (AIDS) is on the rise. Most drug combinations used for treatment of AIDS incorporate nevirapine, resistance to which develops very fast if given singly or because of unplanned interruptions. This paper investigates presence of mutations at codon 103 and codon 215 of the HIV pol gene causing resistance to nevirapine and zidovudine (AZT) respectively in 25 children with AIDS. Mutations T215Y and K103N were detected by a nested cum amplification refractory mutation system polymerase chain reaction (ARMS PCR) and the results were confirmed by direct sequencing in five randomly selected cases. Nineteen patients had received nevirapine containing regimen and six were drug naive. Mutation K103N was observed in 56% (14/25) of the children while mutation T215Y was found in none. Two of the six drug naïve children also showed K103N mutation. Thus, Indian children drug naïve or treated with nevirapine containing regimens show a high rate of mutation conferring resistance to nevirapine which calls for a judicious use of nevirapine both in antenatal and postnatal setting.

  14. Use and Storage of Test and Operations Data from the High Temperature Test Reactor Acquired by the US Government from the Japan Atomic Energy Agency

    SciTech Connect

    Hans Gougar

    2010-02-01

    This document describes the use and storage of data from the High Temperature Test Reactor (HTTR) acquired from the Japan Atomic Energy Agency (JAEA) by the U.S. Government for high temperature reactor research under the Next Generation Nuclear Plant (NGNP) Project.

  15. Integrating Quality into the Textile and Apparel High School Curriculum.

    ERIC Educational Resources Information Center

    Meyer, Deborah J. C.; Kadolph, Sara J.; Cosbey, Sarah; Hillery, Julie; Haar, Sherry; Day, Marla; Keiser, Sandra; Brandes, Kendra

    2001-01-01

    Explains the importance of quality assurance in high school textiles and apparel instruction. Describes educational activities that integrate quality assurance concepts (teamwork, continuous improvement, customer focus, and empowerment). (Contains 23 references.) (SK)

  16. Evidence of Frontal Rupturing in the Mentawai Gap, SW Sumatra, Newly Acquired High-Resolution Seismic Reflection and Bathymetry Data

    NASA Astrophysics Data System (ADS)

    Hananto, N.; Singh, S. C.; Tapponnier, P.; Sieh, K.; Carton, H. D.; Leclerc, F.; Carson, S.; Wei, S.; Nugroho, A. B.; Avianto, P.; Gemilang, W. A.; Duperray, R.; Permana, H.

    2015-12-01

    We present here the first results of the Mentawai Gap Tsunami Earthquake Research Assessment (MEGATERA) survey, conducted onboard R/V Falkor of the Schmidt Ocean Institute from 23 May-29 July 2015. The Mentawai Gap, located along the Sunda subduction zone offshore SW Sumatra, has been inferred to have the potential to produce a devastating great earthquake in the near future. Along this segment of the megathrust, only limited/small patches ruptured on 12 September 2007, during a twin earthquake of Mw = 8.5 and 7.9, and on October 25th, 2010, during the Mw=7.8 shallow earthquake that generated a large tsunami with run-up of up to ~8 m on Pagai islands. To better understand the mechanism of tsunamigenesis in general and better assess this hazard in the Mentawai locked zone in particular, we acquired a total of 1725 km high-resolution seismic reflection data across the subduction front along with more than 10000 km2 of multibeam bathymetry data. Along the Mentawai trench, we imaged the 2010 tsunami earthquake rupture zone, the Mentawai locked zone, the region impinged by the Investigator Fracture zone as well as the bending-related normal faults dissecting the incoming plate. We find that the morphology of the frontal accretionary wedge section within both the region ruptured in 2010 and the locked segment consists of multiple folds bounded by double-vergent active faults, which when activated during a megathrust event could generate a large tsunami. We also find evidence of mass wasting along thrust escarpments, which could be erosional features or more likely landslides scars triggered by earthquake shaking. The density and distribution of these geologic features along strike could give clues on the seismic history of the segments. These new data will allow us to elucidate the tsunamigenic potential of the Mentawai locked zone.

  17. Uncoupling High Light Responses from Singlet Oxygen Retrograde Signaling and Spatial-Temporal Systemic Acquired Acclimation1[OPEN

    PubMed Central

    Gordon, Matthew; Havaux, Michel; Albrecht-Borth, Verónica

    2016-01-01

    Distinct ROS signaling pathways initiated by singlet oxygen (1O2) or superoxide and hydrogen peroxide have been attributed to either cell death or acclimation, respectively. Recent studies have revealed that more complex antagonistic and synergistic relationships exist within and between these pathways. As specific chloroplastic ROS signals are difficult to study, rapid systemic signaling experiments using localized high light (HL) stress or ROS treatments were used in this study to uncouple signals required for direct HL and ROS perception and distal systemic acquired acclimation (SAA). A qPCR approach was chosen to determine local perception and distal signal reception. Analysis of a thylakoidal ascorbate peroxidase mutant (tapx), the 1O2-retrograde signaling double mutant (ex1/ex2), and an apoplastic signaling double mutant (rbohD/F) revealed that tAPX and EXECUTER 1 are required for both HL and systemic acclimation stress perception. Apoplastic membrane-localized RBOHs were required for systemic spread of the signal but not for local signal induction in directly stressed tissues. Endogenous ROS treatments revealed a very strong systemic response induced by a localized 1 h induction of 1O2 using the conditional flu mutant. A qPCR time course of 1O2 induced systemic marker genes in directly and indirectly connected leaves revealed a direct vascular connection component of both immediate and longer term SAA signaling responses. These results reveal the importance of an EXECUTER-dependent 1O2 retrograde signal for both local and long distance RBOH-dependent acclimation signaling that is distinct from other HL signaling pathways, and that direct vascular connections have a role in spatial-temporal SAA induction. PMID:27288360

  18. High prevalence of hospital-acquired infections caused by gram-negative carbapenem resistant strains in Vietnamese pediatric ICUs

    PubMed Central

    Le, Ngai Kien; HF, Wertheim; Vu, Phu Dinh; Khu, Dung Thi Khanh; Le, Hai Thanh; Hoang, Bich Thi Ngoc; Vo, Vu Thanh; Lam, Yen Minh; Vu, Dung Tien Viet; Nguyen, Thu Hoai; Thai, Tung Quang; Nilsson, Lennart E.; Rydell, Ulf; Nguyen, Kinh Van; Nadjm, Behzad; Clarkson, Louise; Hanberger, Håkan; Larsson, Mattias

    2016-01-01

    Abstract There is scarce information regarding hospital-acquired infections (HAIs) among children in resource-constrained settings. This study aims to measure prevalence of HAIs in Vietnamese pediatric hospitals. Monthly point prevalence surveys (PPSs) in 6 pediatric intensive care units (ICUs) in 3 referral hospitals during 1 year. A total of 1363 cases (1143 children) were surveyed, 59.9% male, average age 11 months. Admission sources were: other hospital 49.3%, current hospital 36.5%, and community 15.3%. Reasons for admission were: infectious disease (66%), noninfectious (20.8%), and surgery/trauma (11.3%). Intubation rate was 47.8%, central venous catheter 29.4%, peripheral venous catheter 86.2%, urinary catheter 14.6%, and hemodialysis/filtration 1.7%. HAI was diagnosed in 33.1% of the cases: pneumonia (52.2%), septicemia (26.4%), surgical site infection (2%), and necrotizing enterocolitis (2%). Significant risk factors for HAI included age under 7 months, intubation and infection at admission. Microbiological findings were reported in 212 cases (43%) with 276 isolates: 50 Klebsiella pneumoniae, 46 Pseudomonas aeruginosa, and 39 Acinetobacter baumannii, with carbapenem resistance detected in 55%, 71%, and 65%, respectively. Staphylococcus aureus was cultured in 18 cases, with 81% methicillin-resistant Staphylococcus aureus. Most children (87.6%) received antibiotics, with an average of 1.6 antibiotics per case. Colistin was administered to 96 patients, 93% with HAI and 49% with culture confirmed carbapenem resistance. The high prevalence of HAI with carbapenem resistant gram-negative strains and common treatment with broad-spectrum antibiotics and colistin suggests that interventions are needed to prevent HAI and to optimize antibiotic use. PMID:27399106

  19. Drone-acquired structure-from-motion photogrammetry for high-precision measurements of biomass in semi-arid rangelands

    NASA Astrophysics Data System (ADS)

    Cunliffe, Andrew; Brazier, Richard; Anderson, Karen

    2016-04-01

    Covering 40% of the terrestrial surface, dryland ecosystems have a distinct vegetation structure that is strongly linked to their function. Recent global modelling studies have indicated interannual variations in semiarid ecosystem biomass accounts for ca. 40%-60% of interannual variations in atmospheric carbon dioxide concentrations. Empirical evidence is needed to validate these model predictions; however, existing survey approaches cannot provide sufficiently precise data at landscape-scale extents to quantify this structure appropriately. Using a small unpiloted aerial system (UAS) to acquire aerial photographs and processing using structure-from-motion (SfM) photogrammetry, three dimensional models were produced quantifying the vegetation structure of semi-arid ecosystems at seven areas of interest (AOI). This approach yielded ultrafine (<1 cm2) spatial resolution canopy height models over landscape-scales (10 ha), which resolved individual grass tussocks just a few cm3 in volume. Canopy height cumulative distributions for each AOI illustrated ecologically-significant differences in ecosystem structure over a grass- to shrub-dominated vegetation transition. Strong coefficients of determination (r2 >0.64) supported prediction of aboveground biomass from canopy volume. Canopy volumes, modelled biomass and carbon stocks were sensitive to spatial changes in vegetation community structure. We demonstrate the use of an inexpensive UAS and SfM photogrammetry to produce ultrafine-scale biophysical data products. The high-precision of this approach affords sensitivity to subtle differences in the biotic structure (and therefore function) of heterogeneous ecosystems subject to rapid environmental change, and has exciting potential to revolutionise the study of spatial ecology in ecosystems with either spatially or temporally discontinuous canopy cover.

  20. Do-Not-Resuscitate Orders and/or Hospice Care, Psychological Health, and Quality of Life among Children/Adolescents with Acquired Immune Deficiency Syndrome

    PubMed Central

    Lyon, Maureen E.; Williams, Paige L.; Woods, Elizabeth R.; Hutton, Nancy; Butler, Anne M.; Sibinga, Erica; Brady, Michael T.; Oleske, James M.

    2009-01-01

    Objective The frequency of do-not-resuscitate (DNR) orders and hospice enrollment in children/adolescents living with acquired immune deficiency syndrome (AIDS) and followed in Pediatric AIDS Clinical Trials Group (PACTG) Study 219C was examined, and evaluated for any association with racial disparities or enhanced quality of life (QOL), particularly psychological adjustment. Methods A cross-sectional analysis of children with AIDS enrolled in this prospective multicenter observational study between 2000 and 2005 was conducted to evaluate the incidence of DNR/hospice overall and by calendar time. Linear regression models were used to compare caregivers' reported QOL scores within 6 domains between those with and without DNR/hospice care, adjusting for confounders. Results Seven hundred twenty-six (726) children with AIDS had a mean age of 12.9 years (standard deviation [SD] = 4.5), 51% were male, 60% black, 25% Hispanic. Twenty-one (2.9%) had either a DNR order (n = 16), hospice enrollment (n = 7), or both (n = 2). Of 41 children who died, 80% had no DNR/hospice care. Increased odds of DNR/hospice were observed for those with CD4% less than 15%, no current antiretroviral use, and prior hospitalization. No differences by race were detected. Adjusted mean QOL scores were significantly lower for those with DNR/hospice enrollment than those without across all domains except for psychological status and health care utilization. Poorer psychological status correlated with higher symptom distress, but not with DNR/hospice enrollment after adjusting for symptoms. Conclusions Children who died of AIDS rarely had DNR/hospice enrollment. National guidelines recommend that quality palliative care be integrated routinely with HIV care. Further research is needed to explore the barriers to palliative care and advance care planning in this population. PMID:18363489

  1. Developing high quality low cost healthcare goods.

    PubMed

    Fox, Stephen

    2002-06-01

    The quality and cost of healthcare is a major concern in both Britain and America. Yet, despite much debate and many initiatives, the provision of healthcare is often unreliable and expensive (Goldsmith, 2001). In this article by Dr Stephen Fox, it is proposed that wider application of design methodologies during the development of healthcare goods could make a significant contribution to increasing quality and reducing costs.

  2. High Efficiency, Illumination Quality OLEDs for Lighting

    SciTech Connect

    Joseph Shiang; James Cella; Kelly Chichak; Anil Duggal; Kevin Janora; Chris Heller; Gautam Parthasarathy; Jeffery Youmans; Joseph Shiang

    2008-03-31

    The goal of the program was to demonstrate a 45 lumen per watt white light device based upon the use of multiple emission colors through the use of solution processing. This performance level is a dramatic extension of the team's previous 15 LPW large area illumination device. The fundamental material system was based upon commercial polymer materials. The team was largely able to achieve these goals, and was able to deliver to DOE a 90 lumen illumination source that had an average performance of 34 LPW a 1000 cd/m{sup 2} with peak performances near 40LPW. The average color temperature is 3200K and the calculated CRI 85. The device operated at a brightness of approximately 1000cd/m{sup 2}. The use of multiple emission colors particularly red and blue, provided additional degrees of design flexibility in achieving white light, but also required the use of a multilayered structure to separate the different recombination zones and prevent interconversion of blue emission to red emission. The use of commercial materials had the advantage that improvements by the chemical manufacturers in charge transport efficiency, operating life and material purity could be rapidly incorporated without the expenditure of additional effort. The program was designed to take maximum advantage of the known characteristics of these material and proceeded in seven steps. (1) Identify the most promising materials, (2) assemble them into multi-layer structures to control excitation and transport within the OLED, (3) identify materials development needs that would optimize performance within multilayer structures, (4) build a prototype that demonstrates the potential entitlement of the novel multilayer OLED architecture (5) integrate all of the developments to find the single best materials set to implement the novel multilayer architecture, (6) further optimize the best materials set, (7) make a large area high illumination quality white OLED. A photo of the final deliverable is shown. In

  3. Investigation and identification of etiologies involved in the development of acquired hydronephrosis in aged laboratory mice with the use of high-frequency ultrasound imaging

    PubMed Central

    Springer, Danielle A.; Allen, Michele; Hoffman, Victoria; Brinster, Lauren; Starost, Matthew F.; Bryant, Mark; Eckhaus, Michael

    2014-01-01

    Laboratory mice develop naturally occurring lesions that affect biomedical research. Hydronephrosis is a recognized pathologic abnormality of the mouse kidney. Acquired hydronephrosis can affect any mouse, as it is caused by any naturally occurring disease that impairs free urine flow. Many etiologies leading to this condition are of particular significance to aging mice. Non-invasive ultrasound imaging detects renal pelvic dilation, renal enlargement, and parenchymal loss for pre-mortem identification of this condition. High-frequency ultrasound transducers produce high-resolution images of small structures, ideal for detecting organ pathology in mice. Using a 40 MHz linear array transducer, we obtained high-resolution images of a diversity of pathologic lesions occurring within the abdomen of seven geriatric mice with acquired hydronephrosis that enabled a determination of the underlying etiology. Etiologies diagnosed from the imaging results include pyelonephritis, neoplasia, urolithiasis, mouse urologic syndrome, and spontaneous hydronephrosis, and were confirmed at necropsy. A retrospective review of abdominal scans from an additional 149 aging mice shows that the most common etiologies associated with acquired hydronephrosis are mouse urologic syndrome and abdominal neoplasia. This report highlights the utility of high-frequency ultrasound for surveying research mice for age-related pathology, and is the first comprehensive report of multiple cases of acquired hydronephrosis in mice. PMID:25143818

  4. 36 CFR 910.31 - High architectural quality.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... architectural quality. Development must maintain a uniformly high standard of architecture, representative of... architectural treatment of new buildings, particularly in terms of massing, facade design (including...

  5. 36 CFR 910.31 - High architectural quality.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... architectural quality. Development must maintain a uniformly high standard of architecture, representative of... architectural treatment of new buildings, particularly in terms of massing, facade design (including...

  6. Extraction of high-quality RNA from human articular cartilage.

    PubMed

    Le Bleu, Heather K; Kamal, Fadia A; Kelly, Meghan; Ketz, John P; Zuscik, Michael J; Elbarbary, Reyad A

    2017-02-01

    Extracting high-quality RNA from articular cartilage is challenging due to low cellularity and high proteoglycan content. This problem hinders efficient application of RNA sequencing (RNA-seq) analysis in studying cartilage homeostasis. Here we developed a method that purifies high-quality RNA directly from cartilage. Our method optimized the collection and homogenization steps so as to minimize RNA degradation, and modified the conventional TRIzol protocol to enhance RNA purity. Cartilage RNA purified using our method has appropriate quality for RNA-seq experiments including an RNA integrity number of ∼8. Our method also proved efficient in extracting high-quality RNA from subchondral bone.

  7. Motivating medical employees toward high quality work.

    PubMed

    Zinober, J W

    1992-01-01

    In her continuing series on human relation, Joan Wagner Zinober, Ph.D., M.B.A., discusses the intricacies of motivating medical staff. This article looks at the principles of motivation and provides ideas for improving the quality and quantity of employee work.

  8. 36 CFR 910.31 - High architectural quality.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false High architectural quality. 910.31 Section 910.31 Parks, Forests, and Public Property PENNSYLVANIA AVENUE DEVELOPMENT CORPORATION... architectural quality. Development must maintain a uniformly high standard of architecture, representative...

  9. 36 CFR 910.31 - High architectural quality.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false High architectural quality. 910.31 Section 910.31 Parks, Forests, and Public Property PENNSYLVANIA AVENUE DEVELOPMENT CORPORATION... architectural quality. Development must maintain a uniformly high standard of architecture, representative...

  10. Quality Assurance Strategy for Existing Homes. Final Quality Management Primer for High Performing Homes

    SciTech Connect

    Del Bianco, M.; Taggart, J.; Sikora, J.; Wood, A.

    2012-12-01

    This guide is designed to help Building America (BA) teams understand quality management and its role in transitioning from conventional to high performance home building and remodeling. It explains what quality means, the value of quality management systems, the unique need for QMS when building high performing homes, and the first steps to a implementing a comprehensive QMS. This document provides a framework and context for BA teams when they encounter builders and remodelers.

  11. Quality Assurance Strategy for Existing Homes: Final Quality Management Primer for High Performing Homes

    SciTech Connect

    Del Bianco, M.; Taggart, J.; Sikora, J.; Wood, A.

    2012-12-01

    This guide is designed to help Building America (BA) Teams understand quality management and its role in transitioning from conventional to high performance home building and remodeling. It explains what quality means, the value of quality management systems, the unique need for QMS when building high performing homes, and the first steps to a implementing a comprehensive QMS. This document provides a framework and context for BA teams when they encounter builders and remodelers.

  12. Indoor Air Quality in High Performance Schools

    EPA Pesticide Factsheets

    High performance schools are facilities that improve the learning environment while saving energy, resources, and money. The key is understanding the lifetime value of high performance schools and effectively managing priorities, time, and budget.

  13. Inequality in Preschool Quality? Community-Level Disparities in Access to High-Quality Learning Environments

    ERIC Educational Resources Information Center

    Bassok, Daphna; Galdo, Eva

    2016-01-01

    In recent years, unequal access to high-quality preschool has emerged as a growing public policy concern. Because of data limitations, it is notoriously difficult to measure disparities in access to early learning opportunities across communities and particularly challenging to quantify gaps in access to "high-quality" programs. Research…

  14. Pneumococcal Conjugated Vaccine Reduces the High Mortality for Community-Acquired Pneumonia in the Elderly: an Italian Regional Experience

    PubMed Central

    Gallo, Tolinda; Furlan, Patrizia; Romor, Pierantonio; Bertoncello, Chiara; Buja, Alessandra; Baldovin, Tatjana

    2016-01-01

    Background Community-acquired pneumonia (CAP) is an important cause of illness and death worldwide, particularly among the elderly. Previous studies on the factors associated with mortality in patients hospitalized for CAP revealed a direct association between the type of microorganism involved, the characteristics of the patient and mortality. Vaccination status against pneumococcal disease was not considered. We conducted a retrospective analysis on the mortality rates after a first hospitalization for CAP in north-east Italy with a view to examining especially the role of anti-pneumococcal vaccination as a factor associated with pneumonia-related mortality at one year. Method Between 2012–2013, patients aged 65+ hospitalized with a primary diagnosis of CAP, identified based on International Classification of Diseases, Ninth Revision, Clinical Modification codes 481–486, were enrolled in the study only once. Patients were divided into three groups by pneumococcal vaccination status: 1) 13-valent pneumococcal conjugate vaccine (PCV13) prior to their hospitalization; 2) 23-valent pneumococcal polysaccharide vaccine (PPV23) within 5 years before hospitalization and 3) unvaccinated or PPV23 more than 5 years prior to admission. Gender, age, length of hospital stay and influenza vaccination were considered. Comorbidities were ascertained by means of a properly coded diagnosis. Every patient was followed up for 1 year and the outcome investigated was mortality for any cause and for pneumonia. Results A total of 4,030 patient were included in the study; mean age at the time of admission to hospital was 84.3±7.7; 50.9% were female. 74.2% of subjects had at least one comorbidity; 73.7% has been vaccinated against influenza. Regard to pneumococcal vaccine, 80.4% of patients were not vaccinated, 14.5% vaccinated with PPV23 and 5.1% with PCV13. The 1-year survival rates after hospitalization for pneumonia were 83.6%, 85.9% and 89.3% in the unvaccinated, PPV23 and PCV13

  15. Acquired Cystic Kidney Disease

    MedlinePlus

    ... They Work Kidney Disease A-Z Acquired Cystic Kidney Disease What is acquired cystic kidney disease? Acquired cystic kidney disease happens when a ... cysts. What are the differences between acquired cystic kidney disease and polycystic kidney disease? Acquired cystic kidney ...

  16. High-quality continuous random networks

    NASA Astrophysics Data System (ADS)

    Barkema, G. T.; Mousseau, Normand

    2000-08-01

    The continuous random network (CRN) model is an idealized model for perfectly coordinated amorphous semiconductors. The quality of a CRN can be assessed in terms of topological and configurational properties, including coordination, bond-angle distributions, and deformation energy. Using a variation on the sillium approach proposed 14 years ago by Wooten, Winer, and Weaire, we present 1000-atom and 4096-atom configurations with a degree of strain significantly less than the best CRN available at the moment and comparable to experimental results. The low strain is also reflected in the electronic properties. The electronic density of state obtained from ab initio calculation shows a perfect band gap, without any defect, in agreement with experimental data.

  17. Boiler for generating high quality vapor

    NASA Technical Reports Server (NTRS)

    Gray, V. H.; Marto, P. J.; Joslyn, A. W.

    1972-01-01

    Boiler supplies vapor for use in turbines by imparting a high angular velocity to the liquid annulus in heated rotating drum. Drum boiler provides a sharp interface between boiling liquid and vapor, thereby, inhibiting the formation of unwanted liquid droplets.

  18. The High Flying Leadership Qualities: What Matters the Most

    DTIC Science & Technology

    2016-04-01

    IATIO N THE HIGH FLYING Leadership Qualities: What Matters the Most? Col Robert L. Tremaine, USAF (Ret.) Like many U.S. companies, the Department...level leaders (SLLs), or equivalent offer a gateway to learn more about what leadership qualities matter to them. At the Defense Acquisition University...level managers (SLMs) have to say about the leadership qualities that matter most during their own continuing professional development journey

  19. High quality tunable Brillouin optoelectronic oscillator

    NASA Astrophysics Data System (ADS)

    Mousa, Mohamed; Ahmed, Mahmoud H.; Hassan, Kamel M. M.; Abouelatta, Mohamed; Afifi, Abdelrahman E.

    2016-09-01

    An optical scheme to improve the quality of an RF signal is proposed. The 6 dB linewidth is reduced to sub hertz and the low frequency noise below 1 KHz is reduced about 10 dB. The scheme utilizes a Brillouin-semiconductor optical amplifier (SOA) ring laser fitted with an RF intensity modulator and an APD detector. The experimental results show cavity modes with FSR of 30.57 KHz due to Brillouin fiber length of 6.6 km and 6 dB bandwidth of 780 mHz typical of Brillouin lasers. The gain of the SOA balances out most of the losses in the ring mainly that due to the RF modulator. The modulated optical signal beats at the APD. The optical loop acts as a cavity filter to the RF signal. A jitter in the cavity resonances due to temperature variations is completely eliminated from the output beat signal. There is a 10 dB increase in the phase noise at the FSR frequency and its harmonics. The setup is tested with signals generated by different sources and to frequencies up to 10 GHz, the limit of the APD. Sources with RF linewidth less than the optical FSR produces one output mode with sub-hertz line width. For larger line width signals more than one RF frequency is produced, separated by the FSR, each showing the Brillouin linewidth.

  20. Highly Integrated Quality Assurance – An Empirical Case

    SciTech Connect

    Drake Kirkham; Amy Powell; Lucas Rich

    2011-02-01

    Highly Integrated Quality Assurance – An Empirical Case Drake Kirkham1, Amy Powell2, Lucas Rich3 1Quality Manager, Radioisotope Power Systems (RPS) Program, Idaho National Laboratory, P.O. Box 1625 M/S 6122, Idaho Falls, ID 83415-6122 2Quality Engineer, RPS Program, Idaho National Laboratory 3Quality Engineer, RPS Program, Idaho National Laboratory Contact: Voice: (208) 533-7550 Email: Drake.Kirkham@inl.gov Abstract. The Radioisotope Power Systems Program of the Idaho National Laboratory makes an empirical case for a highly integrated Quality Assurance function pertaining to the preparation, assembly, testing, storage and transportation of 238Pu fueled radioisotope thermoelectric generators. Case data represents multiple campaigns including the Pluto/New Horizons mission, the Mars Science Laboratory mission in progress, and other related projects. Traditional Quality Assurance models would attempt to reduce cost by minimizing the role of dedicated Quality Assurance personnel in favor of either functional tasking or peer-based implementations. Highly integrated Quality Assurance adds value by placing trained quality inspectors on the production floor side-by-side with nuclear facility operators to enhance team dynamics, reduce inspection wait time, and provide for immediate, independent feedback. Value is also added by maintaining dedicated Quality Engineers to provide for rapid identification and resolution of corrective action, enhanced and expedited supply chain interfaces, improved bonded storage capabilities, and technical resources for requirements management including data package development and Certificates of Inspection. A broad examination of cost-benefit indicates highly integrated Quality Assurance can reduce cost through the mitigation of risk and reducing administrative burden thereby allowing engineers to be engineers, nuclear operators to be nuclear operators, and the cross-functional team to operate more efficiently. Applicability of this case

  1. Human immunodeficiency virus (HIV) is highly associated with giant idiopathic esophageal ulcers in acquired immunodeficiency syndrome (AIDS) patients

    PubMed Central

    Lv, Bei; Cheng, Xin; Gao, Jackson; Zhao, Hong; Chen, Liping; Wang, Liwei; Huang, Shaoping; Fan, Zhenyu; Zhang, Renfang; Shen, Yinzhong; Li, Lei; Liu, Baochi; Qi, Tangkai; Wang, Jing; Cheng, Jilin

    2016-01-01

    Objective: This study aimed to determine whether the human immunodeficiency virus (HIV) exists in giant idiopathic esophageal ulcers in the patients with acquired immune deficiency syndrome (AIDS). Methods: 16 AIDS patients with a primary complaint of epigastric discomfort were examined by gastroscopy. Multiple and giant esophageal ulcers were biopsied and analyzed with pathology staining and reverse transcription-polymerase chain reaction (RT-PCR) to determine the potential pathogenic microorganisms, including HIV, cytomegalovirus (CMV) and herpes simplex viruses (HSV). Results: HIV was detected in ulcer samples from 12 out of these 16 patients. Ulcers in 2 patients were infected with CMV and ulcers in another 2 patients were found HSV positive. No obvious cancerous pathological changes were found in these multiple giant esophageal ulcer specimens. Conclusion: HIV may be one of the major causative agents of multiple benign giant esophageal ulcers in AIDS patients. PMID:27830031

  2. Developing High-Quality Teachers: Teacher Evaluation for Improvement

    ERIC Educational Resources Information Center

    Looney, Janet

    2011-01-01

    As countries aim to ensure high achievement for all students, improving and sustaining the quality of the teacher workforce is a vital policy priority. Several studies have found that well-designed teacher evaluation systems, aligned with professional learning and development, can contribute to improvements in the quality of teaching and raise…

  3. The Equitable Distribution of High-Quality Teachers

    ERIC Educational Resources Information Center

    Bumgardner, Stan

    2010-01-01

    A new report by the National Comprehensive Center for Teacher Quality (TQ Center) highlights efforts across the nation to address a key point in the No Child Left Behind law and the American Recovery and Reinvestment Act (ARRA)--the equitable distribution of high-quality teachers across all schools. Research consistently has pointed to effective…

  4. Comparative performance of wavelets and JPEG coders at high quality

    NASA Astrophysics Data System (ADS)

    Algazi, V. Ralph; Estes, Robert R., Jr.

    1997-04-01

    In recent work, we have examined the performance of wavelet coders using a perceptually relevant image quality metric, the picture quality scale (PQS). In that study, we considered some of the design options available with respect to choice of wavelet basis, quantizer, and method for error- free encoding of the quantized coefficients, including the EZW methodology. A specific combination of these design options provides the best trade off between performance and PQS quality. Here, we extend this comparison by evaluating the performance of JPEG and the previously chosen optimal wavelet scheme, focusing principally on the high quality range.

  5. High quality transparent conducting oxide thin films

    DOEpatents

    Gessert, Timothy A.; Duenow, Joel N.; Barnes, Teresa; Coutts, Timothy J.

    2012-08-28

    A transparent conducting oxide (TCO) film comprising: a TCO layer, and dopants selected from the elements consisting of Vanadium, Molybdenum, Tantalum, Niobium, Antimony, Titanium, Zirconium, and Hafnium, wherein the elements are n-type dopants; and wherein the transparent conducting oxide is characterized by an improved electron mobility of about 42 cm.sup.2/V-sec while simultaneously maintaining a high carrier density of .about.4.4e.times.10.sup.20 cm.sup.-3.

  6. Promoting High-Quality Family Child Care: A Policy Perspective for Quality 2000.

    ERIC Educational Resources Information Center

    Modigliani, Kathy

    Although family child care has the potential to offer young children individual attention and customized, educational programs to help them thrive, the quality of these programs is dependent upon a workforce that is at the bottom of the occupational status and pay hierarchy. This report examines ways to promote high quality in family child care…

  7. Emblems of Quality in Higher Education. Developing and Sustaining High-Quality Programs.

    ERIC Educational Resources Information Center

    Haworth, Jennifer Grant; Conrad, Clifton F.

    This book proposes an "engagement" theory of program quality to evaluate and improve higher education programs at all degree levels. Based on interviews with 781 participants in a national study of Masters degree programs, it focuses on the interactive roles of students, faculty, and administrators in developing high-quality programs…

  8. Satellite transitions acquired in real time by magic angle spinning (STARTMAS): ``Ultrafast'' high-resolution MAS NMR spectroscopy of spin I =3/2 nuclei

    NASA Astrophysics Data System (ADS)

    Thrippleton, Michael J.; Ball, Thomas J.; Wimperis, Stephen

    2008-01-01

    The satellite transitions acquired in real time by magic angle spinning (STARTMAS) NMR experiment combines a train of pulses with sample rotation at the magic angle to refocus the first- and second-order quadrupolar broadening of spin I =3/2 nuclei in a series of echoes, while allowing the isotropic chemical and quadrupolar shifts to evolve. The result is real-time isotropic NMR spectra at high spinning rates using conventional MAS equipment. In this paper we describe in detail how STARTMAS data can be acquired and processed with ease on commercial equipment. We also discuss the advantages and limitations of the approach and illustrate the discussion with numerical simulations and experimental data from four different powdered solids.

  9. Management of data quality of high level waste characterization

    SciTech Connect

    Winters, W.I., Westinghouse Hanford

    1996-06-12

    Over the past 10 years, the Hanford Site has been transitioning from nuclear materials production to Site cleanup operations. High-level waste characterization at the Hanford Site provides data to support present waste processing operations, tank safety programs, and future waste disposal programs. Quality elements in the high-level waste characterization program will be presented by following a sample through the data quality objective, sampling, laboratory analysis and data review process. Transition from production to cleanup has resulted in changes in quality systems and program; the changes, as well as other issues in these quality programs, will be described. Laboratory assessment through quality control and performance evaluation programs will be described, and data assessments in the laboratory and final reporting in the tank characterization reports will be discussed.

  10. Delivering High-Quality Cancer Care: The Critical Role of Quality Measurement

    PubMed Central

    Spinks, Tracy; Ganz, Patricia A.; Sledge, George W.; Levit, Laura; Hayman, James A.; Eberlein, Timothy J.; Feeley, Thomas W.

    2014-01-01

    In 1999, the Institute of Medicine (IOM) published Ensuring Quality Cancer Care, an influential report that described an ideal cancer care system and issued ten recommendations to address pervasive gaps in the understanding and delivery of quality cancer care. Despite generating much fervor, the report’s recommendations—including two recommendations related to quality measurement—remain largely unfulfilled. Amidst continuing concerns regarding increasing costs and questionable quality of care, the IOM charged a new committee with revisiting the 1999 report and with reassessing national cancer care, with a focus on the aging US population. The committee identified high-quality patient-clinician relationships and interactions as central drivers of quality and attributed existing quality gaps, in part, to the nation’s inability to measure and improve cancer care delivery in a systematic way. In 2013, the committee published its findings in Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis, which included two recommendations that emphasize coordinated, patient-centered quality measurement and information technology enhancements: Develop a national quality reporting program for cancer care as part of a learning health care system; and,Develop an ethically sound learning health care information technology system for cancer that enables real-time analysis of data from cancer patients in a variety of care settings. These recommendations underscore the need for independent national oversight, public-private collaboration, and substantial funding to create robust, patient-centered quality measurement and learning enterprises to improve the quality, accessibility, and affordability of cancer care in America. PMID:24839592

  11. Delivering High-Quality Cancer Care: The Critical Role of Quality Measurement.

    PubMed

    Spinks, Tracy; Ganz, Patricia A; Sledge, George W; Levit, Laura; Hayman, James A; Eberlein, Timothy J; Feeley, Thomas W

    2014-03-01

    In 1999, the Institute of Medicine (IOM) published Ensuring Quality Cancer Care, an influential report that described an ideal cancer care system and issued ten recommendations to address pervasive gaps in the understanding and delivery of quality cancer care. Despite generating much fervor, the report's recommendations-including two recommendations related to quality measurement-remain largely unfulfilled. Amidst continuing concerns regarding increasing costs and questionable quality of care, the IOM charged a new committee with revisiting the 1999 report and with reassessing national cancer care, with a focus on the aging US population. The committee identified high-quality patient-clinician relationships and interactions as central drivers of quality and attributed existing quality gaps, in part, to the nation's inability to measure and improve cancer care delivery in a systematic way. In 2013, the committee published its findings in Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis, which included two recommendations that emphasize coordinated, patient-centered quality measurement and information technology enhancements: Develop a national quality reporting program for cancer care as part of a learning health care system; and,Develop an ethically sound learning health care information technology system for cancer that enables real-time analysis of data from cancer patients in a variety of care settings. These recommendations underscore the need for independent national oversight, public-private collaboration, and substantial funding to create robust, patient-centered quality measurement and learning enterprises to improve the quality, accessibility, and affordability of cancer care in America.

  12. Memory CD8+ T cells from naturally-acquired primary dengue virus infection are highly cross-reactive

    PubMed Central

    Friberg, Heather; Burns, Lynne; Woda, Marcia; Kalayanarooj, Siripen; Endy, Timothy P.; Stephens, Henry A.F.; Green, Sharone; Rothman, Alan L.; Mathew, Anuja

    2010-01-01

    Cross-reactive memory T cells induced by primary infection with one of the four serotypes of dengue virus (DENV) are hypothesized to play an immunopathological role in secondary heterologous DENV infection. To define the T cell response to heterologous serotypes, we isolated HLA-A*1101-restricted epitope-specific CD8+ T cell lines from primary DENV-immune donors. Cell lines exhibited marked cross-reactivity towards peptide variants representing the four DENV serotypes in tetramer binding and functional assays. Many clones responded similarly to homologous and heterologous serotypes with striking cross-reactivity between the DENV-1 and DENV-3 epitope variants. In vitro-stimulated T cell lines consistently revealed a hierarchical induction of MIP-1β > degranulation > TNFα > IFNγ, which depended on the concentration of agonistic peptide. Phosphoflow assays demonstrated peptide dose-dependent phosphorylation of ERK1/2, which correlated with cytolysis, degranulation, and induction of TNFα and IFNγ but not MIP-1β production. This is the first study to demonstrate significant DENV serotype-cross-reactivity of CD8+ T cells after naturally-acquired primary infection. We also demonstrate qualitatively different T cell receptor signaling after stimulation with homologous and heterologous peptides. Our data support a model whereby the order of sequential DENV infections influences the immune response to secondary heterologous DENV infection, contributing to varying disease outcomes. PMID:20421879

  13. Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8+ Memory Stem Cells in Acquired Aplastic Anemia.

    PubMed

    Hosokawa, Kohei; Muranski, Pawel; Feng, Xingmin; Townsley, Danielle M; Liu, Baoying; Knickelbein, Jared; Keyvanfar, Keyvan; Dumitriu, Bogdan; Ito, Sawa; Kajigaya, Sachiko; Taylor, James G; Kaplan, Mariana J; Nussenblatt, Robert B; Barrett, A John; O'Shea, John; Young, Neal S

    2016-02-15

    Memory stem T cells (TSCMs) constitute a long-lived, self-renewing lymphocyte population essential for the maintenance of functional immunity. Hallmarks of autoimmune disease pathogenesis are abnormal CD4(+) and CD8(+) T cell activation. We investigated the TSCM subset in 55, 34, 43, and 5 patients with acquired aplastic anemia (AA), autoimmune uveitis, systemic lupus erythematosus, and sickle cell disease, respectively, as well as in 41 age-matched healthy controls. CD8(+) TSCM frequency was significantly increased in AA compared with healthy controls. An increased CD8(+) TSCM frequency at diagnosis was associated with responsiveness to immunosuppressive therapy, and an elevated CD8(+) TSCM population after immunosuppressive therapy correlated with treatment failure or relapse in AA patients. IFN-γ and IL-2 production was significantly increased in various CD8(+) and CD4(+) T cell subsets in AA patients, including CD8(+) and CD4(+) TSCMs. CD8(+) TSCM frequency was also increased in patients with autoimmune uveitis or sickle cell disease. A positive correlation between CD4(+) and CD8(+) TSCM frequencies was found in AA, autoimmune uveitis, and systemic lupus erythematosus. Evaluation of PD-1, CD160, and CD244 expression revealed that TSCMs were less exhausted compared with other types of memory T cells. Our results suggest that the CD8(+) TSCM subset is a novel biomarker and a potential therapeutic target for AA.

  14. Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8+ Memory Stem Cells in Acquired Aplastic Anemia

    PubMed Central

    Hosokawa, Kohei; Muranski, Pawel; Feng, Xingmin; Townsley, Danielle M.; Liu, Baoying; Knickelbein, Jared; Keyvanfar, Keyvan; Dumitriu, Bogdan; Ito, Sawa; Kajigaya, Sachiko; Taylor, James G.; Kaplan, Mariana J.; Nussenblatt, Robert B.; Barrett, A. John; O’Shea, John; Young, Neal S.

    2015-01-01

    Memory stem T cells (TSCMs) constitute a long-lived, self-renewing lymphocyte population essential for the maintenance of functional immunity. Hallmarks of autoimmune disease pathogenesis are abnormal CD4+ and CD8+ T cell activation. We investigated the TSCM subset in 55, 34, 43, and 5 patients with acquired aplastic anemia (AA), autoimmune uveitis, systemic lupus erythematosus, and sickle cell disease, respectively, as well as in 41 age-matched healthy controls. CD8+ TSCM frequency was significantly increased in AA compared with healthy controls. An increased CD8+ TSCM frequency at diagnosis was associated with responsiveness to immunosuppressive therapy, and an elevated CD8+ TSCM population after immunosuppressive therapy correlated with treatment failure or relapse in AA patients. IFN-γ and IL-2 production was significantly increased in various CD8+ and CD4+ T cell subsets in AA patients, including CD8+ and CD4+ TSCMs. CD8+ TSCM frequency was also increased in patients with autoimmune uveitis or sickle cell disease. A positive correlation between CD4+ and CD8+ TSCM frequencies was found in AA, autoimmune uveitis, and systemic lupus erythematosus. Evaluation of PD-1, CD160, and CD244 expression revealed that TSCMs were less exhausted compared with other types of memory T cells. Our results suggest that the CD8+ TSCM subset is a novel biomarker and a potential therapeutic target for AA. PMID:26764034

  15. Memory CD8+ T cells from naturally acquired primary dengue virus infection are highly cross-reactive.

    PubMed

    Friberg, Heather; Burns, Lynne; Woda, Marcia; Kalayanarooj, Siripen; Endy, Timothy P; Stephens, Henry A F; Green, Sharone; Rothman, Alan L; Mathew, Anuja

    2011-01-01

    Cross-reactive memory T cells induced by primary infection with one of the four serotypes of dengue virus (DENV) are hypothesized to have an immunopathological function in secondary heterologous DENV infection. To define the T-cell response to heterologous serotypes, we isolated HLA-A(*)1101-restricted epitope-specific CD8(+) T-cell lines from primary DENV-immune donors. Cell lines exhibited marked cross-reactivity toward peptide variants representing the four DENV serotypes in tetramer binding and functional assays. Many clones responded similarly to homologous and heterologous serotypes with striking cross-reactivity between the DENV-1 and DENV-3 epitope variants. In vitro-stimulated T-cell lines consistently revealed a hierarchical induction of MIP-1β>degranulation>tumor necrosis factor α (TNFα)>interferon-γ (IFNγ), which depended on the concentration of agonistic peptide. Phosphoflow assays showed peptide dose-dependent phosphorylation of ERK1/2, which correlated with cytolysis, degranulation, and induction of TNFα and IFNγ, but not MIP-1β production. This is the first study to show significant DENV serotype-cross-reactivity of CD8(+) T cells after naturally acquired primary infection. We also show qualitatively different T-cell receptor signaling after stimulation with homologous and heterologous peptides. Our data support a model whereby the order of sequential DENV infections influences the immune response to secondary heterologous DENV infection, contributing to varying disease outcomes.

  16. High quality x-ray absorption spectroscopy measurements with long energy range at high pressure using diamond anvil cell

    SciTech Connect

    Hong, X.; Newville, M.; Prakapenka, V.B.; Rivers, M.L.; Sutton, S.R.

    2009-07-31

    We describe an approach for acquiring high quality x-ray absorption fine structure (XAFS) spectroscopy spectra with wide energy range at high pressure using diamond anvil cell (DAC). Overcoming the serious interference of diamond Bragg peaks is essential for combining XAFS and DAC techniques in high pressure research, yet an effective method to obtain accurate XAFS spectrum free from DAC induced glitches has been lacking. It was found that these glitches, whose energy positions are very sensitive to the relative orientation between DAC and incident x-ray beam, can be effectively eliminated using an iterative algorithm based on repeated measurements over a small angular range of DAC orientation, e.g., within {+-}3{sup o} relative to the x-ray beam direction. Demonstration XAFS spectra are reported for rutile-type GeO{sub 2} recorded by traditional ambient pressure and high pressure DAC methods, showing similar quality at 440 eV above the absorption edge. Accurate XAFS spectra of GeO{sub 2} glass were obtained at high pressure up to 53 GPa, providing important insight into the structural polymorphism of GeO{sub 2} glass at high pressure. This method is expected be applicable for in situ XAFS measurements using a diamond anvil cell up to ultrahigh pressures.

  17. Concrete Waste Recycling Process for High Quality Aggregate

    SciTech Connect

    Ishikura, Takeshi; Fujii, Shin-ichi

    2008-01-15

    Large amount of concrete waste generates during nuclear power plant (NPP) dismantling. Non-contaminated concrete waste is assumed to be disposed in a landfill site, but that will not be the solution especially in the future, because of decreasing tendency of the site availability and natural resources. Concerning concrete recycling, demand for roadbeds and backfill tends to be less than the amount of dismantled concrete generated in a single rural site, and conventional recycled aggregate is limited of its use to non-structural concrete, because of its inferior quality to ordinary natural aggregate. Therefore, it is vital to develop high quality recycled aggregate for general uses of dismantled concrete. If recycled aggregate is available for high structural concrete, the dismantling concrete is recyclable as aggregate for industry including nuclear field. Authors developed techniques on high quality aggregate reclamation for large amount of concrete generated during NPP decommissioning. Concrete of NPP buildings has good features for recycling aggregate; large quantity of high quality aggregate from same origin, record keeping of the aggregate origin, and little impurities in dismantled concrete such as wood and plastics. The target of recycled aggregate in this development is to meet the quality criteria for NPP concrete as prescribed in JASS 5N 'Specification for Nuclear Power Facility Reinforced Concrete' and JASS 5 'Specification for Reinforced Concrete Work'. The target of recycled aggregate concrete is to be comparable performance with ordinary aggregate concrete. The high quality recycled aggregate production techniques are assumed to apply for recycling for large amount of non-contaminated concrete. These techniques can also be applied for slightly contaminated concrete dismantled from radiological control area (RCA), together with free release survey. In conclusion: a technology on dismantled concrete recycling for high quality aggregate was developed

  18. Broken symmetry dielectric resonators for high quality factor Fano metasurfaces

    SciTech Connect

    Campione, Salvatore; Liu, Sheng; Basilio, Lorena I.; Warne, Larry K.; Langston, William L.; Luk, Ting S.; Wendt, Joel R.; Reno, John L.; Keeler, Gordon A.; Brener, Igal; Sinclair, Michael B.

    2016-10-25

    We present a new approach to dielectric metasurface design that relies on a single resonator per unit cell and produces robust, high quality factor Fano resonances. Our approach utilizes symmetry breaking of highly symmetric resonator geometries, such as cubes, to induce couplings between the otherwise orthogonal resonator modes. In particular, we design perturbations that couple “bright” dipole modes to “dark” dipole modes whose radiative decay is suppressed by local field effects in the array. Our approach is widely scalable from the near-infrared to radio frequencies. We first unravel the Fano resonance behavior through numerical simulations of a germanium resonator-based metasurface that achieves a quality factor of ~1300 at ~10.8 μm. Then, we present two experimental demonstrations operating in the near-infrared (~1 μm): a silicon-based implementation that achieves a quality factor of ~350; and a gallium arsenide-based structure that achieves a quality factor of ~600, the highest near-infrared quality factor experimentally demonstrated to date with this kind of metasurface. Importantly, large electromagnetic field enhancements appear within the resonators at the Fano resonant frequencies. Here, we envision that combining high quality factor, high field enhancement resonances with nonlinear and active/gain materials such as gallium arsenide will lead to new classes of active optical devices.

  19. Broken symmetry dielectric resonators for high quality factor Fano metasurfaces

    DOE PAGES

    Campione, Salvatore; Liu, Sheng; Basilio, Lorena I.; ...

    2016-10-25

    We present a new approach to dielectric metasurface design that relies on a single resonator per unit cell and produces robust, high quality factor Fano resonances. Our approach utilizes symmetry breaking of highly symmetric resonator geometries, such as cubes, to induce couplings between the otherwise orthogonal resonator modes. In particular, we design perturbations that couple “bright” dipole modes to “dark” dipole modes whose radiative decay is suppressed by local field effects in the array. Our approach is widely scalable from the near-infrared to radio frequencies. We first unravel the Fano resonance behavior through numerical simulations of a germanium resonator-based metasurfacemore » that achieves a quality factor of ~1300 at ~10.8 μm. Then, we present two experimental demonstrations operating in the near-infrared (~1 μm): a silicon-based implementation that achieves a quality factor of ~350; and a gallium arsenide-based structure that achieves a quality factor of ~600, the highest near-infrared quality factor experimentally demonstrated to date with this kind of metasurface. Importantly, large electromagnetic field enhancements appear within the resonators at the Fano resonant frequencies. Here, we envision that combining high quality factor, high field enhancement resonances with nonlinear and active/gain materials such as gallium arsenide will lead to new classes of active optical devices.« less

  20. Realization of high quality production schedules: Structuring quality factors via iteration of user specification processes

    NASA Technical Reports Server (NTRS)

    Hamazaki, Takashi

    1992-01-01

    This paper describes an architecture for realizing high quality production schedules. Although quality is one of the most important aspects of production scheduling, it is difficult, even for a user, to specify precisely. However, it is also true that the decision as to whether a scheduler is good or bad can only be made by the user. This paper proposes the following: (1) the quality of a schedule can be represented in the form of quality factors, i.e. constraints and objectives of the domain, and their structure; (2) quality factors and their structure can be used for decision making at local decision points during the scheduling process; and (3) that they can be defined via iteration of user specification processes.

  1. Developing Visions of High-Quality Mathematics Instruction

    ERIC Educational Resources Information Center

    Munter, Charles

    2014-01-01

    This article introduces an interview-based instrument that was created for the purposes of characterizing the visions of high-quality mathematics instruction of teachers, principals, mathematics coaches, and district leaders and tracking changes in those visions over time. The instrument models trajectories of perceptions of high-quality…

  2. Quality Assurance and Statistics. High-Technology Training Module.

    ERIC Educational Resources Information Center

    Wirsbinski, William

    This high technology quality assurance and statistics training module is a part of the statistics unit for an algebra I or algebra II course. This module fits into high school math classes in which students compute and display measures of central tendency and variability. The module contains a description, objectives, and content outline--phase I…

  3. Process to Continuously Melt, Refine and Cast High Quality Steel

    SciTech Connect

    2005-09-01

    The purpose of this project is to conduct research and development targeted at designing a revolutionary steelmaking process. This process will deliver high quality steel from scrap to the casting mold in one continuous process and will be safer, more productive, and less capital intensive to build and operate than conventional steelmaking. The new process will produce higher quality steel faster than traditional batch processes while consuming less energy and other resources.

  4. The efficacy of high-dose penicillin for community-acquired pneumonia diagnosed by pneumococcal urine antigen test.

    PubMed

    Oka, Hideaki; Ueda, Atsuhisa; Watanuki, Yuji; Tsukiji, Jun; Kuroda, Hideyo; Akashi, Syunsuke; Hirai, Yoshihiro; Fuyuki, Toshiharu; Kaneko, Takeshi; Ishigatsubo, Yoshiaki

    2009-04-01

    We analyzed the efficacy of both the Streptococcus pneumoniae urine antigen test as a quick diagnostic tool and the administration of high-dose penicillin in response to a positive S. pneumoniae urine antigen test. We conducted a retrospective analysis of 48 cases of pneumococcal pneumonia, in which the patients were treated with high-dose penicillin. All the cases were diagnosed by a positive urine antigen test. Treatment with high-dose penicillin was effective in 43 of the 48 patients. This treatment was also effective in 12 of 16 culture-confirmed cases with low susceptibility to penicillin. Eleven patients who were positive for the S. pneumoniae urine antigen test but culture-negative showed clinical improvement with high-dose penicillin. Pneumonia caused by S. pneumoniae appeared to be treated safely and effectively with high-dose penicillin based on positive results of the urine antigen test, as penicillin resistance was unlikely to be a problem.

  5. Quality of service on high-speed data networks

    NASA Astrophysics Data System (ADS)

    Barbero, Ezio; Antonelli, Ferruccio

    1995-02-01

    Since the beginning of this century the issue of `quality' has been gaining increasing importance in a number of fields of human activities. For telecommunication services, too, the quality perceived by customers has been taken into account early on as an issue of strategic importance. Whilst for telephony the Quality of Service (QoS) has been already investigated and identified in terms of parameters and related test methodology, the situation for high speed data services (i.e. CBDS/SMDS, Frame Relay, etc.), provided by means of high speed network based on Asynchronous Transfer Moe (ATM) or Metropolitan Area Network technologies, can still be considered `under study'. There is a death of experience not only in terms of measurement instruments and procedures, but also in terms of knowledge of the relationship between the QoS provided at a network level and the quality perceived by the user on his or her terminal. The complexity of the equipment involved in setting up an end-to-end solution based on high speed data communications makes the problems of knowledge and supply of quality very hard to solve. Starting from the experience gained in carrying out high- speed network field trials based on Metropolitan Area Networks and, more recently, on ATM technology, the paper mainly deals with the problem of defining, measuring and then offering a specific QoS. First, the issue of what the user expects from the `high-speed network' is addressed. This analysis is carried out trying to gather what is peculiar to high-speed data communications from the user standpoint. Next, the focus is on how to cope with the requirements due to users' expectations, while carefully considering the basic principles of quality. Finally, a solution is proposed, starting from the experience gained from high speed networks installed in Italy.

  6. Physician incentives to improve quality and the delivery of high quality ambulatory medical care

    PubMed Central

    Bishop, Tara F.; Federman, Alex D.; Ross, Joseph S.

    2012-01-01

    Objective To determine the prevalence of physician incentives for quality and to test the hypothesis that quality of ambulatory medical care is better by physicians with these incentives. Study Design Cross-sectional study using data from the National Ambulatory Medical Care Survey Method We examined the association between physician compensation based on quality, physician compensation based on satisfaction, and public reporting of practice measures and twelve measures of high quality ambulatory care. Results Overall, 20.8% of visits were to physicians whose compensation was partially based on quality, 17.7% of visits were to physicians whose compensation was partially based on patient satisfaction, and 10.0% of visits were to physicians who publicly reported performance measures. Quality of ambulatory care varied: weight reduction counseling occurred in 12.0% of preventative care visits by obese patients whereas urinalysis was not performed in 93.0% of preventative care visits. In multivariable analyses, there were no statistically significant associations between compensation for quality and delivery of any of the 12 measures, nor between compensation for satisfaction and 11 of the 12 measures; the exception was BMI screening in preventative visits (47.8% vs. 56.2%, adjusted p=0.004). There was also no statistically significant association between public reporting and delivery of 11 of 12 measures; the exception was weight reduction counseling for overweight patients (10.0% vs. 25.5%, adjusted p=0.01). Conclusions We found no consistent association between incentives for quality and 12 measures of high quality ambulatory care. PMID:22554038

  7. Questa Baseline and Pre-Mining Ground-Water Quality Investigation. 1. Depth to Bedrock Determinations Using Shallow Seismic Data Acquired in the Straight Creek Drainage Near Red River, New Mexico

    USGS Publications Warehouse

    Powers, Michael H.; Burton, Bethany L.

    2004-01-01

    In late May and early June of 2002, the U.S. Geological Survey (USGS) acquired four P-wave seismic profiles across the Straight Creek drainage near Red River, New Mexico. The data were acquired to support a larger effort to investigate baseline and pre-mining ground-water quality in the Red River basin (Nordstrom and others, 2002). For ground-water flow modeling, knowledge of the thickness of the valley fill material above the bedrock is required. When curved-ray refraction tomography was used with the seismic first arrival times, the resulting images of interval velocity versus depth clearly show a sharp velocity contrast where the bedrock interface is expected. The images show that the interpreted buried bedrock surface is neither smooth nor sharp, but it is clearly defined across the valley along the seismic line profiles. The bedrock models defined by the seismic refraction images are consistent with the well data.

  8. High quality factor etchless silicon photonic ring resonators.

    PubMed

    Luo, Lian-Wee; Wiederhecker, Gustavo S; Cardenas, Jaime; Poitras, Carl; Lipson, Michal

    2011-03-28

    We demonstrate high quality factor etchless silicon photonic ring resonators fabricated by selective thermal oxidation of silicon without the silicon layer being exposed to any plasma etching throughout the fabrication process. We achieve a high intrinsic quality factor of 510,000 in 50 µm-radius ring resonators, corresponding to a ring loss of 0.8 dB/cm. The device has a total chip insertion loss of 2.5 dB, achieved by designing etchless silicon inverse nanotapers at both the input and output of the chip.

  9. Can patients reliably identify safe, high quality care?

    PubMed Central

    Tevis, Sarah E.; Schmocker, Ryan K.; Kennedy, Gregory D.

    2015-01-01

    The Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey is a publicly reported tool that measures patient satisfaction. As both patients and Centers for Medicare & Medicaid Services (CMS) reimbursement rely on survey results as a metric of quality of care, we reviewed the current literature to determine if patient satisfaction correlates with quality, safety, or patient outcomes. We found varying associations between safety culture, process of care measure compliance, and patient outcomes with patient satisfaction on the HCAHPS survey. Some studies found inverse relationships between quality and safety metrics and patient satisfaction. The measure that most reliably correlated with high patient satisfaction was low readmission rate. Future studies using patient specific data are needed to better identify which factors most influence patient satisfaction and to determine if patient satisfaction is a marker of safer and better quality care. Furthermore, the HCAHPS survey should continue to undergo evaluations to assure it generates predictable results. PMID:26413179

  10. High Polyhydroxybutyrate Production in Pseudomonas extremaustralis Is Associated with Differential Expression of Horizontally Acquired and Core Genome Polyhydroxyalkanoate Synthase Genes

    PubMed Central

    Catone, Mariela V.; Ruiz, Jimena A.; Castellanos, Mildred; Segura, Daniel; Espin, Guadalupe; López, Nancy I.

    2014-01-01

    Pseudomonas extremaustralis produces mainly polyhydroxybutyrate (PHB), a short chain length polyhydroxyalkanoate (sclPHA) infrequently found in Pseudomonas species. Previous studies with this strain demonstrated that PHB genes are located in a genomic island. In this work, the analysis of the genome of P. extremaustralis revealed the presence of another PHB cluster phbFPX, with high similarity to genes belonging to Burkholderiales, and also a cluster, phaC1ZC2D, coding for medium chain length PHA production (mclPHA). All mclPHA genes showed high similarity to genes from Pseudomonas species and interestingly, this cluster also showed a natural insertion of seven ORFs not related to mclPHA metabolism. Besides PHB, P. extremaustralis is able to produce mclPHA although in minor amounts. Complementation analysis demonstrated that both mclPHA synthases, PhaC1 and PhaC2, were functional. RT-qPCR analysis showed different levels of expression for the PHB synthase, phbC, and the mclPHA synthases. The expression level of phbC, was significantly higher than the obtained for phaC1 and phaC2, in late exponential phase cultures. The analysis of the proteins bound to the PHA granules showed the presence of PhbC and PhaC1, whilst PhaC2 could not be detected. In addition, two phasin like proteins (PhbP and PhaI) associated with the production of scl and mcl PHAs, respectively, were detected. The results of this work show the high efficiency of a foreign gene (phbC) in comparison with the mclPHA core genome genes (phaC1 and phaC2) indicating that the ability of P. extremaustralis to produce high amounts of PHB could be explained by the different expression levels of the genes encoding the scl and mcl PHA synthases. PMID:24887088

  11. Providing high-quality care in primary care settings

    PubMed Central

    Beaulieu, Marie-Dominique; Geneau, Robert; Grande, Claudio Del; Denis, Jean-Louis; Hudon, Éveline; Haggerty, Jeannie L.; Bonin, Lucie; Duplain, Réjean; Goudreau, Johanne; Hogg, William

    2014-01-01

    Abstract Objective To gain a deeper understanding of how primary care (PC) practices belonging to different models manage resources to provide high-quality care. Design Multiple-case study embedded in a cross-sectional study of a random sample of 37 practices. Setting Three regions of Quebec. Participants Health care professionals and staff of 5 PC practices. Methods Five cases showing above-average results on quality-of-care indicators were purposefully selected to contrast on region, practice size, and PC model. Data were collected using an organizational questionnaire; the Team Climate Inventory, which was completed by health care professionals and staff; and 33 individual interviews. Detailed case histories were written and thematic analysis was performed. Main findings The core common feature of these practices was their ongoing effort to make trade-offs to deliver services that met their vision of high-quality care. These compromises involved the same 3 areas, but to varying degrees depending on clinic characteristics: developing a shared vision of high-quality care; aligning resource use with that vision; and balancing professional aspirations and population needs. The leadership of the physician lead was crucial. The external environment was perceived as a source of pressure and dilemmas rather than as a source of support in these matters. Conclusion Irrespective of their models, PC practices’ pursuit of high-quality care is based on a vision in which accessibility is a key component, balanced by appropriate management of available resources and of external environment expectations. Current PC reforms often create tensions rather than support PC practices in their pursuit of high-quality care. PMID:24829023

  12. A Sounding Rocket Mission Concept to Acquire High-Resolution Radiometric Spectra Spanning the 9 nm - 31 nm Wavelength Range

    NASA Technical Reports Server (NTRS)

    Krause, L. Habash; Cirtain, Jonathan; McGuirck, Michael; Pavelitz, Steven; Weber, Ed.; Winebarger, Amy

    2012-01-01

    When studying Solar Extreme Ultraviolet (EUV) emissions, both single-wavelength, two- dimensional (2D) spectroheliograms and multi-wavelength, one-dimensional (1D) line spectra are important, especially for a thorough understanding of the complex processes in the solar magnetized plasma from the base of the chromosphere through the corona. 2D image data are required for a detailed study of spatial structures, whereas radiometric (i.e., spectral) data provide information on relevant atomic excitation/ionization state densities (and thus temperature). Using both imaging and radiometric techniques, several satellite missions presently study solar dynamics in the EUV, including the Solar Dynamics Observatory (SDO), Hinode, and the Solar-Terrestrial Relations Observatory (STEREO). The EUV wavelengths of interest typically span 9 nm to 31 nm, with the shorter wavelengths being associated with the hottest features (e.g., intense flares and bright points) and the longer wavelengths associated with cooler features (e.g., coronal holes and filaments). Because the optical components of satellite instruments degrade over time, it is not uncommon to conduct sounding rocket underflights for calibration purposes. The authors have designed a radiometric sounding rocket payload that could serve as both a calibration underflight for and a complementary scientific mission to the upcoming Solar Ultraviolet Imager (SUVI) mission aboard the GOES-R satellite (scheduled for a 2015 launch). The challenge to provide quality radiometric line spectra over the 9-31 nm range covered by SUVI was driven by the multilayer coatings required to make the optical components, including mirrors and gratings, reflective over the entire range. Typically, these multilayers provide useful EUV reflectances over bandwidths of a few nm. Our solution to this problem was to employ a three-telescope system in which the optical components were coated with multilayers that spanned three wavelength ranges to cover

  13. Large-volume reconstruction of brain tissue from high-resolution serial section images acquired by SEM-based scanning transmission electron microscopy.

    PubMed

    Kuwajima, Masaaki; Mendenhall, John M; Harris, Kristen M

    2013-01-01

    With recent improvements in instrumentation and computational tools, serial section electron microscopy has become increasingly straightforward. A new method for imaging ultrathin serial sections is developed based on a field emission scanning electron microscope fitted with a transmitted electron detector. This method is capable of automatically acquiring high-resolution serial images with a large field size and very little optical and physical distortions. In this chapter, we describe the procedures leading to the generation and analyses of a large-volume stack of high-resolution images (64 μm × 64 μm × 10 μm, or larger, at 2 nm pixel size), including how to obtain large-area serial sections of uniform thickness from well-preserved brain tissue that is rapidly perfusion-fixed with mixed aldehydes, processed with a microwave-enhanced method, and embedded into epoxy resin.

  14. Monitoring reservoir water quality with Formosat-2 high spatiotemporal imagery.

    PubMed

    Chang, Chih-Hua; Liu, Cheng-Chien; Wen, Ching-Gung; Cheng, I-Fan; Tam, Chi-Kin; Huang, Ching-Shiang

    2009-11-01

    Water reservoirs are the primary source of freshwater for most cities around the world. To monitor the dynamic changes in reservoir water quality, however, we need an innovative platform that is able to observe the entire reservoir with both high-spatial- and high-temporal-resolution. Formosat-2 is the first commercial satellite dedicated to site surveillance with a high-spatial-resolution sensor placed in a daily revisit orbit (2 m in panchromatic and 8 m in multispectral). In this research, we developed two empirical algorithms to map the water contents of Chlorophyll-a (Chl-a) and suspended solids (SS) from Formosat-2 multispectral imagery. These algorithms are derived from a total of 53 pairs of water-quality and surface-reflectance data collected during 14 field campaigns at Tsengwen Reservoir from 2005 to 2006. A total of 15 Formosat-2 images were selected from all available images of Tsengwen Reservoir taken in 2006 to generate water quality maps of Chl-a and SS using our new algorithms. Results from this study indicate that the Chl-a and SS concentrations can be retrieved from Formosat-2 imagery with deviations of 56% and 43%, respectively. This is the first time that the reservoir water quality can be mapped from a high-spatial-resolution satellite image at such a high-temporal-resolution. To facilitate the administration of water resources, this research encourages the application of Formosat-2 high spatiotemporal imagery in identifying areas of poor water quality and monitoring the dispersal pattern of pollutant plumes.

  15. Improved electrode gives high-quality biological recordings

    NASA Technical Reports Server (NTRS)

    Day, J. L.; Lippitt, M. W.

    1964-01-01

    To obtain high quality waveforms from a subject engaged in physical activity, an improved electrode assembly has been devised. This consists of a cup containing an electrically conductive paste and a silver electrode. The paste maintains contact between the skin and the plate.

  16. High-quality Health Information Provision for Stroke Patients

    PubMed Central

    Du, Hong-Sheng; Ma, Jing-Jian; Li, Mu

    2016-01-01

    Objective: High-quality information provision can allow stroke patients to effectively participate in healthcare decision-making, better manage the stroke, and make a good recovery. In this study, we reviewed information needs of stroke patients, methods for providing information to patients, and considerations needed by the information providers. Data Sources: The literature concerning or including information provision for patients with stroke in English was collected from PubMed published from 1990 to 2015. Study Selection: We included all the relevant articles on information provision for stroke patients in English, with no limitation of study design. Results: Stroke is a major public health concern worldwide. High-quality and effective health information provision plays an essential role in helping patients to actively take part in decision-making and healthcare, and empowering them to effectively self-manage their long-standing chronic conditions. Different methods for providing information to patients have their relative merits and suitability, and as a result, the effective strategies taken by health professionals may include providing high-quality information, meeting patients’ individual needs, using suitable methods in providing information, and maintaining active involvement of patients. Conclusions: It is suggested that to enable stroke patients to access high-quality health information, greater efforts need to be made to ensure patients to receive accurate and current evidence-based information which meets their individual needs. Health professionals should use suitable information delivery methods, and actively involve stroke patients in information provision. PMID:27569241

  17. Cultivating High-Quality Teaching through Induction and Mentoring

    ERIC Educational Resources Information Center

    Bartell, Carol A.

    2004-01-01

    The first few years of teaching are the most challenging. During these years, teachers are most likely to become discouraged and disillusioned. Yet these early years are also the time when teachers establish practices that last throughout their careers. This book focuses on new teachers' needs while emphasizing high-quality teaching through the…

  18. Measuring the Impact of High Quality Instant Feedback on Learning

    ERIC Educational Resources Information Center

    Nutbrown, Stephen; Higgins, Colin; Beesley, Su

    2016-01-01

    This paper examines the impact of a novel assessment technique that has been used to improve the feedback given to second year Computer Science students at the University of Nottingham. Criteria for effective, high quality feedback are discussed. An automated marking system (The Marker's Apprentice--TMA) produces instant feedback in synergy with…

  19. Total Quality Management (TQM): High School/College Course Material.

    ERIC Educational Resources Information Center

    Leigh, David

    This Total Quality Management (TQM) course was designed to introduce students to the principles and tools of TQM in a full-semester course in high schools or community colleges. The course includes all the competencies found in TQM and is intended to be taught with an interactive method in which students are involved in the learning process. This…

  20. The impact of high speed roller ginning on yarn quality

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Recent advance in cotton ginning technology have resulted in increases in the speed, throughput, and overall economics of roller ginning to make it competitive with conventional saw ginning. The present study was aimed at determining if the improvements in fiber quality, i.e. longer fibers with high...

  1. Attracting and Retaining High-Quality Professionals in Science Education.

    ERIC Educational Resources Information Center

    Weld, Jeffrey

    1998-01-01

    To attract and retain high-quality teachers, the education system must address science teachers' sense of professional isolation, administrators' lack of receptivity to thoughtful teachers' ideas, egalitarian salary compensation schemes, and lack of professional recognition. An outstanding chemistry teacher-turned-pharmaceutical saleswoman is…

  2. Extraction of high-quality RNA from rubber tree leaves.

    PubMed

    Deng, Liu-Hong; Luo, Ming-Wu; Zhang, Chun-Fa; Zeng, Hui-Cai

    2012-01-01

    A specific technique capable of producing high-quality RNA for rapid amplification of cDNA ends (RACE) was established for challenging tissues: leaves of the rubber tree. Total RNA was extracted by cetyltrimethylammonium bromide (CTAB)-LiCl combined with TRIzol reagent. The isolated RNA was highly intact. With RNA as template, full-length cDNA was obtained (NCBI, AY461413) by RACE.

  3. Method for producing high quality thin layer films on substrates

    DOEpatents

    Strongin, M.; Ruckman, M.; Strongin, D.

    1994-04-26

    A method for producing high quality, thin layer films of inorganic compounds upon the surface of a substrate is disclosed. The method involves condensing a mixture of preselected molecular precursors on the surface of a substrate and subsequently inducing the formation of reactive species using high energy photon or charged particle irradiation. The reactive species react with one another to produce a film of the desired compound upon the surface of the substrate. 4 figures.

  4. Method for producing high quality thin layer films on substrates

    DOEpatents

    Strongin, Myron; Ruckman, Mark; Strongin, Daniel

    1994-01-01

    A method for producing high quality, thin layer films of inorganic compounds upon the surface of a substrate is disclosed. The method involves condensing a mixture of preselected molecular precursors on the surface of a substrate and subsequently inducing the formation of reactive species using high energy photon or charged particle irradiation. The reactive species react with one another to produce a film of the desired compound upon the surface of the substrate.

  5. Highly qualified does not equal high quality: A study of urban stakeholders' perceptions of quality in science teaching

    NASA Astrophysics Data System (ADS)

    Miranda, Rommel Joseph

    By employing qualitative methods, this study sought to determine the perceptions that urban stakeholders hold about what characteristics should distinguish a high school science teacher whom they would consider to demonstrate high quality in science teaching. A maximum variation sample of six science teachers, three school administrators, six parents and six students from a large urban public school district were interviewed using semi-structured, in-depth interview techniques. From these data, a list of observable characteristics which urban stakeholders hold as evidence of high quality in science teaching was generated. Observational techniques were utilized to determine the extent to which six urban high school science teachers, who meet the NCLB Act criteria for being "highly qualified", actually possessed the characteristics which these stakeholders hold as evidence of high quality in science teaching. Constant comparative analysis was used to analyze the data set. The findings suggest that urban stakeholders perceive that a high school science teacher who demonstrates high quality in science teaching should be knowledgeable about their subject matter, their student population, and should be resourceful; should possess an academic background in science and professional experience in science teaching; should exhibit professionalism, a passion for science and teaching, and a dedication to teaching and student learning; should be skillful in planning and preparing science lessons and in organizing the classroom, in presenting the subject matter to students, in conducting a variety of hands-on activities, and in managing a classroom; and should assess whether students complete class goals and objectives, and provide feedback about grades for students promptly. The findings further reveal that some of the urban high school science teachers who were deemed to be "highly qualified", as defined by the NCLB Act, engaged in practices that threatened quality in science

  6. Vegetation Fraction Mapping with Artificial Neural Network and High Resolution Multispectral Aerial Imagery Acquired During BEAREX07

    NASA Astrophysics Data System (ADS)

    Kersh, K. L.; Gowda, P. H.; Basu, S.; Howell, T. A.; O'Shaughnessy, S.; Rajan, N.; Akasheh, O. Z.

    2009-12-01

    Land surface models use vegetation fraction to more accurately partition latent, sensible and soil heat fluxes for a partial vegetated surface as it affects energy and moisture exchanges between the earth’s surface and atmosphere. In recent years, there is interest to integrate vegetation fraction data into intelligent irrigation scheduling systems to avoid false positive signals to irrigate. Remote sensing can facilitate the rapid collection of vegetation fraction information on individual fields over large areas in a timely and cost-effective manner. In this study, we developed a set of vegetation fraction models using least square regression and artificial neural network (ANN) techniques and evaluated using the data collected during Bushland Evapotranspiration and Agricultural Remote sensing Experiment 2007 (BEAREX07). During the BEAREX07, six aircraft campaigns were made covering bare soil to full crop cover conditions. High resolution multispectral data include 0.5-m visible (green and red) and near infrared images and 1.8-m thermal infrared images over the USDA-ARS-Conservation and Production Research Laboratory in Bushland, Texas [350 11' N, 1020 06' W; 1,170 m elevation MSL]. Atmospheric corrections were applied on these images before extracting spectral signatures for 40 ground truth locations. Field data collection in ground truth locations during the aircraft campaigns included digital pictures of crop cover using a Red/Infrared camera. Vegetation fraction information was derived from digital photos using a supervised classification. Comparison of performance statistics indicate that ANN performed slightly better than least square regression models. Newly developed fraction vegetation models will be used in the evaluation of land surface energy balance based evapotranspiration models.

  7. Detection of High Quality Rainfall Data to Improve Flood Resilience

    NASA Astrophysics Data System (ADS)

    Hoang, T. C.; Tchiguirinskaia, I.; Schertzer, D. J.; Lovejoy, S.

    2012-12-01

    European flood management systems require reliable rainfall statistics, e.g. the Intensity-duration-Frequency curves for shorter and shorter durations and for a larger and larger range of return periods. Preliminary studies showed that the number of floods depends on the quality of available data, e.g. the time resolution quality. These facts suggest that a particular attention should be paid to the rainfall data quality in order to adequately investigate flood risk aiming to achieve flood resilience. The potential consequences of changes in measuring and recording techniques have been somewhat discussed in the literature with respect to a possible introduction of artificial inhomogeneities in time series. In this direction, we developed a first version of a SERQUAL procedure to automatically detect the effective time resolution of highly mixed data. We show that most of the rainfall time series have a lower recording frequency than that is assumed. This question is particularly important for operational hydrology, because an error on the effective recording high frequency introduces biases in the corresponding statistics. It is therefore essential to quantify the quality of the rainfall time series before their use. Due to the fact that the multiple scales and possible scaling behaviour of hydrological data are particularly important for many applications, including flood resilience research, this paper first investigates the sensitivity of the scaling estimates and methods to the deficit of short duration rainfall data, and consequently propose a few simple criteria for a reliable evaluation of the data quality. The SERQUAL procedure enable us to extract high quality sub-series from longer time series that will be much more reliable to calibrate and/or validate short duration quantiles and hydrological models.

  8. High-Quality T2-Weighted 4-Dimensional Magnetic Resonance Imaging for Radiation Therapy Applications

    SciTech Connect

    Du, Dongsu; Caruthers, Shelton D.; Glide-Hurst, Carri; Low, Daniel A.; Li, H. Harold; Mutic, Sasa; Hu, Yanle

    2015-06-01

    Purpose: The purpose of this study was to improve triggering efficiency of the prospective respiratory amplitude-triggered 4-dimensional magnetic resonance imaging (4DMRI) method and to develop a 4DMRI imaging protocol that could offer T2 weighting for better tumor visualization, good spatial coverage and spatial resolution, and respiratory motion sampling within a reasonable amount of time for radiation therapy applications. Methods and Materials: The respiratory state splitting (RSS) and multi-shot acquisition (MSA) methods were analytically compared and validated in a simulation study by using the respiratory signals from 10 healthy human subjects. The RSS method was more effective in improving triggering efficiency. It was implemented in prospective respiratory amplitude-triggered 4DMRI. 4DMRI image datasets were acquired from 5 healthy human subjects. Liver motion was estimated using the acquired 4DMRI image datasets. Results: The simulation study showed the RSS method was more effective for improving triggering efficiency than the MSA method. The average reductions in 4DMRI acquisition times were 36% and 10% for the RSS and MSA methods, respectively. The human subject study showed that T2-weighted 4DMRI with 10 respiratory states, 60 slices at a spatial resolution of 1.5 × 1.5 × 3.0 mm{sup 3} could be acquired in 9 to 18 minutes, depending on the individual's breath pattern. Based on the acquired 4DMRI image datasets, the ranges of peak-to-peak liver displacements among 5 human subjects were 9.0 to 12.9 mm, 2.5 to 3.9 mm, and 0.5 to 2.3 mm in superior-inferior, anterior-posterior, and left-right directions, respectively. Conclusions: We demonstrated that with the RSS method, it was feasible to acquire high-quality T2-weighted 4DMRI within a reasonable amount of time for radiation therapy applications.

  9. High Quality Factor Mechanical Resonators Based on WSe2 Monolayers

    PubMed Central

    2016-01-01

    Suspended monolayer transition metal dichalcogenides (TMD) are membranes that combine ultralow mass and exceptional optical properties, making them intriguing materials for opto-mechanical applications. However, the low measured quality factor of TMD resonators has been a roadblock so far. Here, we report an ultrasensitive optical readout of monolayer TMD resonators that allows us to reveal their mechanical properties at cryogenic temperatures. We find that the quality factor of monolayer WSe2 resonators greatly increases below room temperature, reaching values as high as 1.6 × 104 at liquid nitrogen temperature and 4.7 × 104 at liquid helium temperature. This surpasses the quality factor of monolayer graphene resonators with similar surface areas. Upon cooling the resonator, the resonant frequency increases significantly due to the thermal contraction of the WSe2 lattice. These measurements allow us to experimentally study the thermal expansion coefficient of WSe2 monolayers for the first time. High Q-factors are also found in resonators based on MoS2 and MoSe2 monolayers. The high quality-factor found in this work opens new possibilities for coupling mechanical vibrational states to two-dimensional excitons, valley pseudospins, and single quantum emitters and for quantum opto-mechanical experiments based on the Casimir interaction. PMID:27459399

  10. Local motion-compensated method for high-quality 3D coronary artery reconstruction

    PubMed Central

    Liu, Bo; Bai, Xiangzhi; Zhou, Fugen

    2016-01-01

    The 3D reconstruction of coronary artery from X-ray angiograms rotationally acquired on C-arm has great clinical value. While cardiac-gated reconstruction has shown promising results, it suffers from the problem of residual motion. This work proposed a new local motion-compensated reconstruction method to handle this issue. An initial image was firstly reconstructed using a regularized iterative reconstruction method. Then a 3D/2D registration method was proposed to estimate the residual vessel motion. Finally, the residual motion was compensated in the final reconstruction using the extended iterative reconstruction method. Through quantitative evaluation, it was found that high-quality 3D reconstruction could be obtained and the result was comparable to state-of-the-art method. PMID:28018741

  11. Local motion-compensated method for high-quality 3D coronary artery reconstruction.

    PubMed

    Liu, Bo; Bai, Xiangzhi; Zhou, Fugen

    2016-12-01

    The 3D reconstruction of coronary artery from X-ray angiograms rotationally acquired on C-arm has great clinical value. While cardiac-gated reconstruction has shown promising results, it suffers from the problem of residual motion. This work proposed a new local motion-compensated reconstruction method to handle this issue. An initial image was firstly reconstructed using a regularized iterative reconstruction method. Then a 3D/2D registration method was proposed to estimate the residual vessel motion. Finally, the residual motion was compensated in the final reconstruction using the extended iterative reconstruction method. Through quantitative evaluation, it was found that high-quality 3D reconstruction could be obtained and the result was comparable to state-of-the-art method.

  12. Highly Superior Autobiographical Memory: Quality and Quantity of Retention Over Time

    PubMed Central

    LePort, Aurora K. R.; Stark, Shauna M.; McGaugh, James L.; Stark, Craig E. L.

    2016-01-01

    Individuals who have Highly Superior Autobiographical Memory (HSAM) are able to recall, with considerable accuracy, details of daily experiences that occurred over many previous decades. The present study parametrically investigates the quantity and quality of details of autobiographical memories acquired 1-week, 1-month, 1-year, and 10-years prior in HSAMs and controls. In addition, we tested the consistency of details provided at the 1-week delay by testing the subjects 1 month later with a surprise assessment. At the 1-week delay, HSAMs and controls recalled an equivalent number of events. In contrast, HSAM recall performance was superior at more remote delays, with remarkable consistency following a 1-month delay. Further, we revealed a relationship between the consistency of recall and HSAMs’ obsessive–compulsive tendencies. These data suggest that HSAMs experience normal encoding, yet enhanced consolidation and later recall of autobiographical events. PMID:26834661

  13. High quality videoconferencing system for wide area IP networks

    NASA Astrophysics Data System (ADS)

    Qiu, Ruibiao; Kuhns, Fred; Cox, Jerome R., Jr.; Horn, Craig

    2002-12-01

    High quality video conferencing is an efficient tool for interactive scientific collaboration in the research community, especially for researchers separated by substantial distance. With the wide deployment of broadband wide area IP networks such as the Internet2, there is an increasing demand for improved remote collaboration with these networks. In order to make the high quality video-conferencing toolkits for local high-speed networks available over wide area IP networks, issues that are usually insignificant on local area networks must be considered. To this end, we have developed called Adaptation Layer Translator (ALX) in order to address these issues and solve the problems associated with real-time video and audio transmission over wide area IP networks. A conference control protocol is developed to coordinate the participants in an ALX-based conference. The ALX is also designed to be able to adapt to heterogeneous network environments at different deployment sites.

  14. Two-Phase Flow Pressure Drop of High Quality Steam

    SciTech Connect

    Curtis, J. M.; Coffield, R. D.

    2001-10-01

    Two-phase pressure drop across a straight test pipe was experimentally determined for high Reynolds (Re) number steam flow for a flow quality range of 0.995 to 1.0. The testing described has been performed in order to reduce uncertainties associated with the effects of two-phase flow on pressure drop. Two-phase flow develops in steam piping because a small fraction of the steam flow condenses due to heat loss to the surroundings. There has been very limited two-phase pressure drop data in open literature for the tested flow quality range. The two-phase pressure drop data obtained in this test has enabled development of a correlation between friction factor, Reynolds number, and flow quality.

  15. Optimum conditions for high-quality 3D reconstruction in confocal scanning microscopy

    NASA Astrophysics Data System (ADS)

    Kim, Taehoon; Kim, Taejoong; Lee, SeungWoo; Gweon, Dae-Gab; Seo, Jungwoo

    2006-02-01

    Confocal Scanning Microscopy (CSM) is very useful to reconstruct 3D image of Bio-cells and the objects that have specification shape in higher axial and lateral resolution and widely used as measurement instrument. A 3D reconstruction is used to visualize confocal images and consists of following processes. The First process is to get 3D data by collecting a series of images at regular focus intervals (Optical Sectioning). The Second process is to fit a curve to a series of 3D data points each pixel. The Third process is to search height information that has maximum value from curve-fitting. However, because of various systematic errors (NOISE) occurred when collecting the information of images through Optical Sectioning and large peak deviation occurred from curve-fitting error, high quality 3D reconstruction is not expected. Also, it takes much time to 3d Reconstruction by using many 3D data in order to acquire high quality and much cost to improve signal-to-noise (SNR) using a higher power laser. So, we are going to define SNR, peak deviation and the order of curve-fitting as important factors and simulate the relation between the factors in order to find a optimum condition for high quality 3D reconstruction in Confoal Scanning Microscopy. If we use optimum condition obtained by this simulation, using a suitable SNR and the suitable number of data and the suitable n-th order curve-fitting, small peak deviation is expected and then, 3D reconstruction of little better quality is expected. Also, it is expected to save.

  16. Development of plasma assisted thermal vapor deposition technique for high-quality thin film

    NASA Astrophysics Data System (ADS)

    Lee, Kang-Il; Choi, Yong Sup; Park, Hyun Jae

    2016-12-01

    The novel technique of Plasma-Assisted Vapor Deposition (PAVD) is developed as a new deposition method for thin metal films. The PAVD technique yields a high-quality thin film without any heating of the substrate because evaporated particles acquire energy from plasma that is confined to the inside of the evaporation source. Experiments of silver thin film deposition have been carried out in conditions of pressure lower than 10-3 Pa. Pure silver plasma generation is verified by the measurement of the Ag-I peak using optical emission spectroscopy. A four point probe and a UV-VIS spectrophotometer are used to measure the electrical and optical properties of the silver film that is deposited by PAVD. For an ultra-thin silver film with a thickness of 6.5 nm, we obtain the result of high-performance silver film properties, including a sheet resistance <20 Ω sq-1 and a visible-range transmittance >75%. The PAVD-film properties show a low sheet resistance of 30% and the same transmittance with conventional thermal evaporation film. In the PAVD source, highly energetic particles and UV from plasma do not reach the substrate because the plasma is completely shielded by the optimized nozzle of the crucible. This new PAVD technique could be a realistic solution to improve the qualities of transparent electrodes for organic light emission device fabrication without causing damage to the organic layers.

  17. Development of plasma assisted thermal vapor deposition technique for high-quality thin film.

    PubMed

    Lee, Kang-Il; Choi, Yong Sup; Park, Hyun Jae

    2016-12-01

    The novel technique of Plasma-Assisted Vapor Deposition (PAVD) is developed as a new deposition method for thin metal films. The PAVD technique yields a high-quality thin film without any heating of the substrate because evaporated particles acquire energy from plasma that is confined to the inside of the evaporation source. Experiments of silver thin film deposition have been carried out in conditions of pressure lower than 10(-3) Pa. Pure silver plasma generation is verified by the measurement of the Ag-I peak using optical emission spectroscopy. A four point probe and a UV-VIS spectrophotometer are used to measure the electrical and optical properties of the silver film that is deposited by PAVD. For an ultra-thin silver film with a thickness of 6.5 nm, we obtain the result of high-performance silver film properties, including a sheet resistance <20 Ω sq(-1) and a visible-range transmittance >75%. The PAVD-film properties show a low sheet resistance of 30% and the same transmittance with conventional thermal evaporation film. In the PAVD source, highly energetic particles and UV from plasma do not reach the substrate because the plasma is completely shielded by the optimized nozzle of the crucible. This new PAVD technique could be a realistic solution to improve the qualities of transparent electrodes for organic light emission device fabrication without causing damage to the organic layers.

  18. High-quality observation of surface imperviousness for urban runoff modelling using UAV imagery

    NASA Astrophysics Data System (ADS)

    Tokarczyk, P.; Leitao, J. P.; Rieckermann, J.; Schindler, K.; Blumensaat, F.

    2015-01-01

    Modelling rainfall-runoff in urban areas is increasingly applied to support flood risk assessment particularly against the background of a changing climate and an increasing urbanization. These models typically rely on high-quality data for rainfall and surface characteristics of the area. While recent research in urban drainage has been focusing on providing spatially detailed rainfall data, the technological advances in remote sensing that ease the acquisition of detailed land-use information are less prominently discussed within the community. The relevance of such methods increase as in many parts of the globe, accurate land-use information is generally lacking, because detailed image data is unavailable. Modern unmanned air vehicles (UAVs) allow acquiring high-resolution images on a local level at comparably lower cost, performing on-demand repetitive measurements, and obtaining a degree of detail tailored for the purpose of the study. In this study, we investigate for the first time the possibility to derive high-resolution imperviousness maps for urban areas from UAV imagery and to use this information as input for urban drainage models. To do so, an automatic processing pipeline with a modern classification method is tested and applied in a state-of-the-art urban drainage modelling exercise. In a real-life case study in the area of Lucerne, Switzerland, we compare imperviousness maps generated from a consumer micro-UAV and standard large-format aerial images acquired by the Swiss national mapping agency (swisstopo). After assessing their correctness, we perform an end-to-end comparison, in which they are used as an input for an urban drainage model. Then, we evaluate the influence which different image data sources and their processing methods have on hydrological and hydraulic model performance. We analyze the surface runoff of the 307 individual subcatchments regarding relevant attributes, such as peak runoff and volume. Finally, we evaluate the model

  19. Enabling high-quality observations of surface imperviousness for water runoff modelling from unmanned aerial vehicles

    NASA Astrophysics Data System (ADS)

    Tokarczyk, Piotr; Leitao, Joao Paulo; Rieckermann, Jörg; Schindler, Konrad; Blumensaat, Frank

    2015-04-01

    Modelling rainfall-runoff in urban areas is increasingly applied to support flood risk assessment particularly against the background of a changing climate and an increasing urbanization. These models typically rely on high-quality data for rainfall and surface characteristics of the area. While recent research in urban drainage has been focusing on providing spatially detailed rainfall data, the technological advances in remote sensing that ease the acquisition of detailed land-use information are less prominently discussed within the community. The relevance of such methods increase as in many parts of the globe, accurate land-use information is generally lacking, because detailed image data is unavailable. Modern unmanned air vehicles (UAVs) allow acquiring high-resolution images on a local level at comparably lower cost, performing on-demand repetitive measurements, and obtaining a degree of detail tailored for the purpose of the study. In this study, we investigate for the first time the possibility to derive high-resolution imperviousness maps for urban areas from UAV imagery and to use this information as input for urban drainage models. To do so, an automatic processing pipeline with a modern classification method is tested and applied in a state-of-the-art urban drainage modelling exercise. In a real-life case study in the area of Lucerne, Switzerland, we compare imperviousness maps generated from a consumer micro-UAV and standard large-format aerial images acquired by the Swiss national mapping agency (swisstopo). After assessing their correctness, we perform an end-to-end comparison, in which they are used as an input for an urban drainage model. Then, we evaluate the influence which different image data sources and their processing methods have on hydrological and hydraulic model performance. We analyze the surface runoff of the 307 individual sub-catchments regarding relevant attributes, such as peak runoff and volume. Finally, we evaluate the model

  20. Radar Backscatter and Coherence Information Supporting High Quality Urban Mapping

    NASA Astrophysics Data System (ADS)

    Fischer, P.; Perski, Z.; Wannemacher, S.

    2004-06-01

    The potential of a synergetic use of different data sources for a high quality mapping of urban features is described in this paper. In the urban application domain, beside the different EO-sensors and products there are a lot of high resolution and high quality GIS- and digital map databases available (e.g. ATKIS in Germany), provided by public authorities but also by private industry. Fusing this ground-based data with remotely sensed information is resulting in high quality thematic datasets. Using ATKIS Geodata, IKONOS multispectral- and ERS-SAR / ENVISAT-ASAR data as input, in the research described we implemented a GIS-based expert system to derive in a first step the degree of sealing in the regions of interest (ROI). Joining the reclassified ATKIS-data with a vegetation index, the backscatter- and the coherence information, the output of the processing chain is a vector data layer dividing the ROI in different classes of sealing. Adding the SAR-/ASAR derived backscatter and coherence data into the spatial analysis results in a partial improvement of the classification process, especially in rural areas.

  1. Mapping of invasive Acacia species in Brazilian Mussununga ecosystems using high- resolution IR remote sensing data acquired with an autonomous Unmanned Aerial System (UAS)

    NASA Astrophysics Data System (ADS)

    Lehmann, Jan Rudolf Karl; Zvara, Ondrej; Prinz, Torsten

    2015-04-01

    The biological invasion of Australian Acacia species in natural ecosystems outside Australia has often a negative impact on native and endemic plant species and the related biodiversity. In Brazil, the Atlantic rainforest of Bahia and Espirito Santo forms an associated type of ecosystem, the Mussununga. In our days this biologically diverse ecosystem is negatively affected by the invasion of Acacia mangium and Acacia auriculiformis, both introduced to Brazil by the agroforestry to increase the production of pulp and high grade woods. In order to detect the distribution of Acacia species and to monitor the expansion of this invasion the use of high-resolution imagery data acquired with an autonomous Unmanned Aerial System (UAS) proved to be a very promising approach. In this study, two types of datasets - CIR and RGB - were collected since both types provide different information. In case of CIR imagery attention was paid on spectral signatures related to plants, whereas in case of RGB imagery the focus was on surface characteristics. Orthophoto-mosaics and DSM/DTM for both dataset were extracted. RGB/IHS transformations of the imagery's colour space were utilized, as well as NDVIblue index in case of CIR imagery to discriminate plant associations. Next, two test areas were defined in order validate OBIA rule sets using eCognition software. In case of RGB dataset, a rule set based on elevation distinction between high vegetation (including Acacia) and low vegetation (including soils) was developed. High vegetation was classified using Nearest Neighbour algorithm while working with the CIR dataset. The IHS information was used to mask shadows, soils and low vegetation. Further Nearest Neighbour classification was used for distinction between Acacia and other high vegetation types. Finally an accuracy assessment was performed using a confusion matrix. One can state that the IHS information appeared to be helpful in Acacia detection while the surface elevation

  2. Towards high-quality optical ceramic YAG fibers for high-energy laser (HEL) applications

    NASA Astrophysics Data System (ADS)

    Lee, HeeDong; Keller, Kristin; Sirn, Brian

    2012-06-01

    There is a critical demand for high quality, transparent ceramic YAG fibers for high powered fiber lasers. The production of laser quality ceramic fibers hinges on advanced ceramic processing technology, along with the availability of highly sinterable powder with high phase and chemical purity. These two fundamental technologies have been successfully developed at UES. Nd (1.1 a/o) and Yb (1.0 a/o)-doped yttrium aluminum garnet (YAG) fibers with high optical quality were produced by combining UES's tailored powders with advanced consolidation processes including fiber extrusion and vacuum sintering. The as-sintered and as-annealed fibers, approximately 30 microns in diameter, appeared transparent and successfully transmitted laser beams; further development will allow for the production of doped ceramic YAG fiber lasers for advanced high power and high energy fiber laser systems.

  3. A high-throughput, high-quality plant genomic DNA extraction protocol.

    PubMed

    Li, H; Li, J; Cong, X H; Duan, Y B; Li, L; Wei, P C; Lu, X Z; Yang, J B

    2013-10-15

    The isolation of high-quality genomic DNA (gDNA) is a crucial technique in plant molecular biology. The quality of gDNA determines the reliability of real-time polymerase chain reaction (PCR) analysis. In this paper, we reported a high-quality gDNA extraction protocol optimized for real-time PCR in a variety of plant species. Performed in a 96-well block, our protocol provides high throughput. Without the need for phenol-chloroform and liquid nitrogen or dry ice, our protocol is safer and more cost-efficient than traditional DNA extraction methods. The method takes 10 mg leaf tissue to yield 5-10 µg high-quality gDNA. Spectral measurement and electrophoresis were used to demonstrate gDNA purity. The extracted DNA was qualified in a restriction enzyme digestion assay and conventional PCR. The real-time PCR amplification was sufficiently sensitive to detect gDNA at very low concentrations (3 pg/µL). The standard curve of gDNA dilutions from our phenol-chloroform-free protocol showed better linearity (R(2) = 0.9967) than the phenol-chloroform protocol (R(2) = 0.9876). The results indicate that the gDNA was of high quality and fit for real-time PCR. This safe, high-throughput plant gDNA extraction protocol could be used to isolate high-quality gDNA for real-time PCR and other downstream molecular applications.

  4. Auto Spell Suggestion for High Quality Speech Synthesis in Hindi

    NASA Astrophysics Data System (ADS)

    Kabra, Shikha; Agarwal, Ritika

    2014-02-01

    The goal of Text-to-Speech (TTS) synthesis in a particular language is to convert arbitrary input text to intelligible and natural sounding speech. However, for a particular language like Hindi, which is a highly confusing language (due to very close spellings), it is not an easy task to identify errors/mistakes in input text and an incorrect text degrade the quality of output speech hence this paper is a contribution to the development of high quality speech synthesis with the involvement of Spellchecker which generates spell suggestions for misspelled words automatically. Involvement of spellchecker would increase the efficiency of speech synthesis by providing spell suggestions for incorrect input text. Furthermore, we have provided the comparative study for evaluating the resultant effect on to phonetic text by adding spellchecker on to input text.

  5. High-quality microcutting in silicon by advanced laser technology

    NASA Astrophysics Data System (ADS)

    Gallus, E.; Castelli, Paolo

    2003-11-01

    This paper reports on the potentialities of innovative lasers in microcutting of silicon, one of the most important materials in the field of microelectronics. In recent years, novel laser based micromachining methods have played an increasingly important role in the ongoing miniaturization of consumer electronics. Here, high-quality microcutting in silicon using a "green" laser, whose wavelength is readily absorbed by silicon, is presented.

  6. Acquired Idiopathic Generalized Anhidrosis.

    PubMed

    Gangadharan, Geethu; Criton, Sebastian; Surendran, Divya

    2015-01-01

    Acquired idiopathic generalized anhidrosis is a rare condition, where the exact pathomechanism is unknown. We report a case of acquired idiopathic generalized anhidrosis in a patient who later developed lichen planus. Here an autoimmune-mediated destruction of sweat glands may be the probable pathomechanism.

  7. LABORATORY-ACQUIRED MYCOSES

    DTIC Science & Technology

    laboratory- acquired mycoses . Insofar as possible, the etiological fungus, type of laboratory, classification of personnel, type of work conducted, and other...pertinent data have been listed in this study. More than 288 laboratory- acquired mycoses are described here, including 108 cases of

  8. Enhancing the quality of radiographic images acquired with point-like gamma-ray sources through correction of the beam divergence and attenuation

    NASA Astrophysics Data System (ADS)

    Silvani, M. I.; Almeida, G. L.; Lopes, R. T.

    2014-11-01

    Radiographic images acquired with point-like gamma-ray sources exhibit a desirable low penumbra effects specially when positioned far away from the set object-detector. Such an arrangement frequently is not affordable due to the limited flux provided by a distant source. A closer source, however, has two main drawbacks, namely the degradation of the spatial resolution - as actual sources are only approximately punctual - and the non-homogeneity of the beam hitting the detector, which creates a false attenuation map of the object being inspected. This non-homogeneity is caused by the beam divergence itself and by the different thicknesses traversed the beam even if the object were an homogeneous flat plate. In this work, radiographic images of objects with different geometries, such as flat plates and pipes have undergone a correction of beam divergence and attenuation addressing the experimental verification of the capability and soundness of an algorithm formerly developed to generate and process synthetic images. The impact of other parameters, including source-detector gap, attenuation coefficient, ratio defective-to-main hull thickness and counting statistics have been assessed for specifically tailored test-objects aiming at the evaluation of the ability of the proposed method to deal with different boundary conditions. All experiments have been carried out with an X-ray sensitive Imaging Plate and reactor-produced 198Au and 165Dy sources. The results have been compared with other technique showing a better capability to correct the attenuation map of inspected objects unveiling their inner structure otherwise concealed by the poor contrast caused by the beam divergence and attenuation, in particular for those regions far apart from the vertical of the source.

  9. Enhancing the quality of radiographic images acquired with point-like gamma-ray sources through correction of the beam divergence and attenuation

    SciTech Connect

    Silvani, M. I.; Almeida, G. L.; Lopes, R. T.

    2014-11-11

    Radiographic images acquired with point-like gamma-ray sources exhibit a desirable low penumbra effects specially when positioned far away from the set object-detector. Such an arrangement frequently is not affordable due to the limited flux provided by a distant source. A closer source, however, has two main drawbacks, namely the degradation of the spatial resolution - as actual sources are only approximately punctual - and the non-homogeneity of the beam hitting the detector, which creates a false attenuation map of the object being inspected. This non-homogeneity is caused by the beam divergence itself and by the different thicknesses traversed the beam even if the object were an homogeneous flat plate. In this work, radiographic images of objects with different geometries, such as flat plates and pipes have undergone a correction of beam divergence and attenuation addressing the experimental verification of the capability and soundness of an algorithm formerly developed to generate and process synthetic images. The impact of other parameters, including source-detector gap, attenuation coefficient, ratio defective-to-main hull thickness and counting statistics have been assessed for specifically tailored test-objects aiming at the evaluation of the ability of the proposed method to deal with different boundary conditions. All experiments have been carried out with an X-ray sensitive Imaging Plate and reactor-produced {sup 198}Au and {sup 165}Dy sources. The results have been compared with other technique showing a better capability to correct the attenuation map of inspected objects unveiling their inner structure otherwise concealed by the poor contrast caused by the beam divergence and attenuation, in particular for those regions far apart from the vertical of the source.

  10. High quality fuel gas from biomass pyrolysis with calcium oxide.

    PubMed

    Zhao, Baofeng; Zhang, Xiaodong; Chen, Lei; Sun, Laizhi; Si, Hongyu; Chen, Guanyi

    2014-03-01

    The removal of CO2 and tar in fuel gas produced by biomass thermal conversion has aroused more attention due to their adverse effects on the subsequent fuel gas application. High quality fuel gas production from sawdust pyrolysis with CaO was studied in this paper. The results of pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) experiments indicate that the mass ratio of CaO to sawdust (Ca/S) remarkably affects the behavior of sawdust pyrolysis. On the basis of Py-GC/MS results, one system of a moving bed pyrolyzer coupled with a fluid bed combustor has been developed to produce high quality fuel gas. The lower heating value (LHV) of the fuel gas was above 16MJ/Nm(3) and the content of tar was under 50mg/Nm(3), which is suitable for gas turbine application to generate electricity and heat. Therefore, this technology may be a promising route to achieve high quality fuel gas for biomass utilization.

  11. Short-term follow-up of exercise training program and beta-blocker treatment on quality of life in dogs with naturally acquired chronic mitral valve disease

    PubMed Central

    Marcondes-Santos, M.; Mansur, A.P.; Fragata, F.S.; Strunz, C.M.C.

    2015-01-01

    This study aimed to evaluate the effects of carvedilol treatment and a regimen of supervised aerobic exercise training on quality of life and other clinical, echocardiographic, and biochemical variables in a group of client-owned dogs with chronic mitral valve disease (CMVD). Ten healthy dogs (control) and 36 CMVD dogs were studied, with the latter group divided into 3 subgroups. In addition to conventional treatment (benazepril, 0.3-0.5 mg/kg once a day, and digoxin, 0.0055 mg/kg twice daily), 13 dogs received exercise training (subgroup I; 10.3±2.1 years), 10 dogs received carvedilol (0.3 mg/kg twice daily) and exercise training (subgroup II; 10.8±1.7 years), and 13 dogs received only carvedilol (subgroup III; 10.9±2.1 years). All drugs were administered orally. Clinical, laboratory, and Doppler echocardiographic variables were evaluated at baseline and after 3 and 6 months. Exercise training was conducted from months 3-6. The mean speed rate during training increased for both subgroups I and II (ANOVA, P>0.001), indicating improvement in physical conditioning at the end of the exercise period. Quality of life and functional class was improved for all subgroups at the end of the study. The N-terminal pro-brain natriuretic peptide (NT-proBNP) level increased in subgroup I from baseline to 3 months, but remained stable after training introduction (from 3 to 6 months). For subgroups II and III, NT-proBNP levels remained stable during the entire study. No difference was observed for the other variables between the three evaluation periods. The combination of carvedilol or exercise training with conventional treatment in CMVD dogs led to improvements in quality of life and functional class. Therefore, light walking in CMVD dogs must be encouraged. PMID:26445331

  12. Low-risk and high-risk histologic features in conjunctival primary acquired melanosis with atypia: Clinicopathologic analysis of 29 cases.

    PubMed

    Sugiura, Mitsuhiro; Colby, Kathryn A; Mihm, Martin C; Zembowicz, Artur

    2007-02-01

    The current World Health Organization classification of conjunctival melanocytic proliferations divides them into conjunctival nevi and invasive melanoma but, in contrast to other anatomic sites, does not recognize melanoma in situ. All atypical intraepithelial conjunctival proliferations are included in a heterogeneous category designated as primary acquired melanosis (PAM) with atypia. We performed clinicopathologic analysis of 29 cases of PAM with atypia. On the basis of histologic features and frequency of association with invasive melanoma and metastases, we were able to divide our cases into 2 histologic groups. The low-risk group (13 cases) included lesions composed of small to medium size melanocytes with high nuclear to cytoplasmic ratio and small to medium size hyperchromatic nuclei devoid of nucleoli showing predominantly single cell lentiginous growth pattern. Invasive melanoma occurred in only 2 cases from this group. None of these lesions metastasized. The second, high-risk group (16 cases), showed increased frequency of association with invasive melanoma (15/16 cases, 94%) and metastases (4/16 cases, 25%). These lesions were more heterogeneous architecturally but were all composed of melanocytes showing various degrees of epithelioid features such as abundant cytoplasm, vesicular nuclei, or prominent nucleoli. In 4 cases discrete areas showing high-risk and low-risk features were identified. All 4 lesions were associated with invasion. Our findings offer a practical approach for prognostically useful subclassification of PAM with atypia, which emphasizes cytologic features of intraepithelial conjunctival melanocytic proliferation.

  13. High quality mask storage in an advanced Logic-Fab

    NASA Astrophysics Data System (ADS)

    Jähnert, Carmen; Fritsche, Silvio

    2012-02-01

    High efficient mask logistics as well as safe and high quality mask storage are essential requirements within an advanced lithography area of a modern logic waferfab. Fast operational availability of the required masks at the exposure tool with excellent mask condition requires a safe mask handling, safeguarding of high mask quality over the whole mask usage time without any quality degradation and an intelligent mask logistics. One big challenge is the prevention of haze on high advanced phase shift masks used in a high volume production line for some thousands of 248nm or 193nm exposures. In 2008 Infineon Dresden qualified a customer specific developed semi-bare mask storage system from DMSDynamic Micro Systems in combination with a high advanced mask handling and an interconnected complex logistic system. This high-capacity mask storage system DMS M1900.22 for more than 3000 masks with fully automated mask and box handling as well as full-blown XCDA purge has been developed and adapted to the Infineon Lithotoollandscape using Nikon and SMIF reticle cases. Advanced features for ESD safety and mask security, mask tracking via RFID and interactions with the exposure tools were developed and implemented. The stocker is remote controlled by the iCADA-RSM system, ordering of the requested mask directly from the affected exposure tool allows fast access. This paper discusses the advantages and challenges for this approach as well as the practical experience gained during the implementation of the new system which improves the fab performance with respect to mask quality, security and throughput. Especially the realization of an extremely low and stable humidity level in addition with a well controlled air flow at each mask surface, preventing masks from haze degradation and particle contamination, turns out to be a notable technical achievement. The longterm stability of haze critical masks has been improved significantly. Relevant environmental parameters like

  14. Sleep quality among elderly high-altitude dwellers in Ladakh.

    PubMed

    Sakamoto, Ryota; Okumiya, Kiyohito; Norboo, Tsering; Tsering, Norboo; Yamaguchi, Takayoshi; Nose, Mitsuhiro; Takeda, Shinya; Tsukihara, Toshihiro; Ishikawa, Motonao; Nakajima, Shun; Wada, Taizo; Fujisawa, Michiko; Imai, Hissei; Ishimoto, Yasuko; Kimura, Yumi; Fukutomi, Eriko; Chen, Wenling; Otsuka, Kuniaki; Matsubayashi, Kozo

    2017-03-01

    It has been already known that people who temporarily stay at high altitude may develop insomnia as a symptom of acute mountain sickness. However, much less is known about people living at high altitude. The aim of this study was to determine the effect of high altitude environment on sleep quality for the elderly who have been living at high altitude for their whole lives. A cross-sectional study was conducted in Domkhar valley at altitudes of 2800-4200m, Ladakh. Sleep quality was assessed using Insomnia Severity Index (ISI). Measurement items include body mass index, blood pressure, blood sugar, hemoglobin, timed Up and Go test, oxygen saturation during wakefulness, respiratory function test, Oxford Knee Score (OKS), and Geriatric Depression Scale (GDS), and so on. The participants were Ladakhi older adults aged 60 years or over (n=112) in Domkhar valley. The participation rate was 65.1% (male: female=47:65, mean age: 71.3 years and 67.9 years, respectively). The prevalence of the high score of ISI (8 or more) was 15.2% (17 out of 112). Altitude of residence was significantly correlated with ISI. Stepwise multiple regression analysis showed that OKS and altitude of residence were significantly related with ISI.

  15. High-throughput Protein Purification and Quality Assessment for Crystallization

    PubMed Central

    Kim, Youngchang; Babnigg, Gyorgy; Jedrzejczak, Robert; Eschenfeldt, William H.; Li, Hui; Maltseva, Natalia; Hatzos-Skintges, Catherine; Gu, Minyi; Makowska-Grzyska, Magdalena; Wu, Ruiying; An, Hao; Chhor, Gekleng; Joachimiak, Andrzej

    2012-01-01

    The ultimate goal of structural biology is to understand the structural basis of proteins in cellular processes. In structural biology, the most critical issue is the availability of high-quality samples. “Structural biology-grade” proteins must be generated in the quantity and quality suitable for structure determination using X-ray crystallography or nuclear magnetic resonance (NMR) spectroscopy. The purification procedures must reproducibly yield homogeneous proteins or their derivatives containing marker atom(s) in milligram quantities. The choice of protein purification and handling procedures plays a critical role in obtaining high-quality protein samples. With structural genomics emphasizing a genome-based approach in understanding protein structure and function, a number of unique structures covering most of the protein folding space have been determined and new technologies with high efficiency have been developed. At the Midwest Center for Structural Genomics (MCSG), we have developed semi-automated protocols for high-throughput parallel protein expression and purification. A protein, expressed as a fusion with a cleavable affinity tag, is purified in two consecutive immobilized metal affinity chromatography (IMAC) steps: (i) the first step is an IMAC coupled with buffer-exchange, or size exclusion chromatography (IMAC-I), followed by the cleavage of the affinity tag using the highly specific Tobacco Etch Virus (TEV) protease; [1] the second step is IMAC and buffer exchange (IMAC-II) to remove the cleaved tag and tagged TEV protease. These protocols have been implemented on multidimensional chromatography workstations and, as we have shown, many proteins can be successfully produced in large-scale. All methods and protocols used for purification, some developed by MCSG, others adopted and integrated into the MCSG purification pipeline and more recently the Center for Structural Genomics of Infectious Diseases (CSGID) purification pipeline, are

  16. High quality (In)GaN films on homoepitaxial substrates

    NASA Astrophysics Data System (ADS)

    Liu, Li; Zhang, Yong; Yin, Yian

    2017-02-01

    High quality GaN and InGaN epitaxial thin films were deposited by metal organic chemical vapor deposition (MOCVD). Two sets of thin film samples were prepared by varying the substrates and temperatures under a proper condition for achieving better optical properties. The morphological, crystalline quality and optical property of epitaxial layers were characterized by atomic force microscope (AFM), X-ray diffraction (XRD), photoluminescence (PL) and Raman spectra, respectively. It was found that the epitaxial layers grown on GaN homoepitaxial substrate have higher quality than those grown on sapphire substrate. The root mean square (RMS) of GaN film and InGaN film in AFM morphological were 0.5 nm, 2.7 nm respectively. The full width at half maximum (FWHM) of (102) in GaN film on GaN substrate was 33arcsec and the FWHM of (002) in InGaN film on GaN substrate was 50.58arcsec by XRD. The PL peaks of GaN film and InGaN film were 361 nm, 458 nm respectively. The E2 (high) of GaN film and InGaN film in Raman were both 567.08 cm-1.

  17. High quality factor resonance at room temperature with nanostrings under high tensile stress

    NASA Astrophysics Data System (ADS)

    Verbridge, Scott S.; Parpia, Jeevak M.; Reichenbach, Robert B.; Bellan, Leon M.; Craighead, H. G.

    2006-06-01

    Quality factors as high as 207 000 are demonstrated at room temperature for radio-frequency silicon nitride string resonators with cross sectional dimensions on the scale of 100 nm, made with a nonlithographic technique. A product of quality factor and surface to volume ratio greater than 6000 nm-1 is presented, the highest yet reported. Doubly clamped nanostring resonators are fabricated in high tensile-stress silicon nitride using a nonlithographic electrospinning process. We fabricate devices with an electron beam process, and demonstrate frequency and quality factor results identical to those obtained with the nonlithographic technique. We also compare high tensile-stress doubly clamped beams with doubly clamped and cantilever resonators made of a lower stress material, as well as cantilever beams made of the high stress material. In all cases, the doubly clamped high stress beams have the highest quality factors. We therefore attribute the high quality factors to high tensile stress. Potential dominant loss mechanisms are discussed, including surface and clamping losses, and thermoelastic dissipation. Some practical advantages offered by these nanostrings for mass sensing are discussed.

  18. High-Quality Broadband BVRI Photometry of Benchmark Open Clusters

    NASA Astrophysics Data System (ADS)

    Joner, Michael D.

    Photometric techniques are often used to observe stars and it can be demonstrated that fundamental stellar properties can be observationally determined using calibrated sets of photometric data. Many of the most powerful techniques utilized to calibrate stellar photometry employ the use of stars in clusters since the individual stars are believed to have many common properties such as age, composition, and approximate distance. Broadband photometric Johnson/Cousins BVRI observations are presented for several nearby open clusters. The new photometry has been tested for consistency relative to archival work and shown to be both accurate and precise. The careful use of a regular routine when making photometric observations, along with the monitoring of instrumental systems and the use of various quality control techniques when making observations or performing data reductions, will enhance an observer's ability to produce high-quality photometric measurements. This work contains a condensed review of the history of photometry, along with a brief description of several popular photometric systems that are often utilized in the field of stellar astrophysics. Publications written by Taylor or produced during the early Taylor and Joner collaboration are deemed especially relevant to the current work. A synopsis of seven archival publications is offered, along with a review of notable reports of VRI photometric observations for the nearby Hyades open star cluster. The body of this present work consists of four publications that appeared between the years 2005 and 2008, along with a soon to be submitted manuscript for a fifth publication. Each of these papers deals specifically with high-quality broadband photometry of open clusters with new data being presented for the Hyades, Coma, NGC 752, Praesepe, and M67. It is concluded that the VRI photometry produced during the Taylor and Joner collaborative investigations forms a high-quality data set that has been: (1) stable for

  19. 2020 vision for a high-quality, high-value maternity care system.

    PubMed

    Carter, Martha Cook; Corry, Maureen; Delbanco, Suzanne; Foster, Tina Clark-Samazan; Friedland, Robert; Gabel, Robyn; Gipson, Teresa; Jolivet, R Rima; Main, Elliott; Sakala, Carol; Simkin, Penny; Simpson, Kathleen Rice

    2010-01-01

    A concrete and useful way to create an action plan for improving the quality of maternity care in the United States is to start with a view of the desired result, a common definition and a shared vision for a high-quality, high-value maternity care system. In this paper, we present a long-term vision for the future of maternity care in the United States. We present overarching values and principles and specific attributes of a high-performing maternity care system. We put forth the "2020 Vision for a High-Quality, High-Value Maternity Care System" to serve as a positive starting place for a fruitful collaborative process to develop specific action steps for broad-based maternity care system improvement.

  20. The synthesis of high-quality diamond in combustion flames

    NASA Astrophysics Data System (ADS)

    Hirose, Yoichi; Amanuma, Shuji; Komaki, Kunio

    1990-12-01

    High-quality diamond with good crystallinity has been successfully synthesized on a substrate using an oxy-acetylene combustion flame in the atmosphere. The crystal grains under some conditions have good optical transparency. The deposition rate of transparent diamond depended strongly on substrate temperatures and the O2/C2H2 ratio and averaged ˜30 μm/h. The substrate temperature for the growth of optically transparent crystals was 500-750 °C, which is relatively low compared with other chemical vapor deposition methods. The optical transparency is attributed to the low defect densities in the crystals, as determined by transmission electron microscope, which results from the low substrate temperatures and moderate growth rates. Raman spectroscopy and x-ray diffraction data on the synthesized crystals were comparable with that of natural diamond. The synthesis conditions and corresponding diamond quality as well as emission spectrum analysis of the combustion flame during diamond synthesis are described.

  1. Low prevalence of fluoroquinolone resistant strains and resistance precursor strains in Streptococcus pneumoniae from patients with community-acquired pneumonia despite high fluoroquinolone usage.

    PubMed

    Pletz, Mathias W; van der Linden, Mark; von Baum, Heike; Duesberg, Christoph B; Klugman, Keith P; Welte, Tobias

    2011-01-01

    We investigated the usage of fluoroquinolones and the prevalence of fluoroquinolone resistant pneumococci and their precursors (first step mutants and efflux expressing isolates) in patients with community-acquired pneumonia, who were enroled into the German CAPNETZ surveillance study from 2002 to 2006 before the introduction of the pneumococcal conjugate vaccine (n=5780). Thirty-eight percent of all outpatients received fluoroquinolones. Moxifloxacin accounted for 70%, levofloxacin for 19% and ciprofloxacin for 9% of all fluoroquinolone prescriptions. One hundred and sixty-three pneumococcal isolates from 556 patients with pneumococcal pneumonia were analyzed for fluoroquinolone resistance, efflux phenotype, prevalence of mutations within the quinolone-resistance determining regions and clonality. None of the isolates exhibited fluoroquinolone resistance, 1.2% of the isolates contained a first step mutation and 6.7% exhibited an efflux phenotype. There was no clonal relationship among these strains at increased risk for fluoroquinolone resistance. The absence of fluoroquinolone resistance in the context of high fluoroquinolone usage might be explained by the high proportion of third-generation fluoroquinolones with enhanced activity against pneumococci.

  2. Acquired inflammatory demyelinating neuropathies.

    PubMed

    Ensrud, E R; Krivickas, L S

    2001-05-01

    The acquired demyelinating neuropathies can be divided into those with an acute onset and course and those with a more chronic course. The acute neuropathies present as Guillain-Barré syndrome and include acute inflammatory demyelinating polyradiculoneuropathy (AIDP), Miller Fisher syndrome, acute motor axonal neuropathy (AMAN), acute motor and sensory axonal neuropathy (AMSAN), and acute pandysautonomia. The chronic neuropathies are collectively known as chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and include MADSAM (multifocal acquired demyelinating sensory and motor neuropathy, also know as Lewis-Sumner syndrome) and DADS (distal acquired demyelinating symmetric neuropathy) as variants. The clinical features, pathology, pathogenesis, diagnosis, treatment, rehabilitation, and prognosis of these neuropathies are discussed.

  3. Acquired color vision deficiency.

    PubMed

    Simunovic, Matthew P

    2016-01-01

    Acquired color vision deficiency occurs as the result of ocular, neurologic, or systemic disease. A wide array of conditions may affect color vision, ranging from diseases of the ocular media through to pathology of the visual cortex. Traditionally, acquired color vision deficiency is considered a separate entity from congenital color vision deficiency, although emerging clinical and molecular genetic data would suggest a degree of overlap. We review the pathophysiology of acquired color vision deficiency, the data on its prevalence, theories for the preponderance of acquired S-mechanism (or tritan) deficiency, and discuss tests of color vision. We also briefly review the types of color vision deficiencies encountered in ocular disease, with an emphasis placed on larger or more detailed clinical investigations.

  4. High Quality Down Lighting Luminaire with 73% Overall System Efficiency

    SciTech Connect

    Robert Harrison; Steven C. Allen; Joseph Bernier; Robert Harrison

    2010-08-31

    This report summarizes work to develop a high flux, high efficiency LED-based downlight at OSRAM SYLVANIA under US Department of Energy contract DE-FC26-08NT01582. A new high power LED and electronic driver were developed for these downlights. The LED achieved 100 lumens per watt efficacy and 1700 lumen flux output at a correlated color temperature of 3500K. The driver had 90% electrical conversion efficiency while maintaining excellent power quality with power factor >0.99, and total harmonic distortion <10%. Two styles of downlights using the LED and driver were shown to exceed the project targets for steady-state luminous efficacy and flux of 70 lumens per watt and 1300 lumens, respectively. Compared to similar existing downlights using compact fluorescent or LED sources, these downlights had much higher efficacy at nearly the same luminous flux.

  5. Designing High Quality Evaluation Systems for High School Teachers: Challenges and Potential Solutions

    ERIC Educational Resources Information Center

    Tyler, John H.

    2011-01-01

    A central part of education reform today is the wide-ranging and unprecedented effort to either revamp existing teacher evaluation systems or develop and implement entirely new systems. High-quality teacher evaluation systems are seen as one lever for improving the teacher workforce and hence the outcomes of students, including high school…

  6. Teacher Resilience in High-Poverty Schools: How Do High-Quality Teachers Become Resilient?

    ERIC Educational Resources Information Center

    Merrill, Kate Mansi

    2013-01-01

    The primary purpose of this study was to understand how high-quality teachers who began their career through Teach For America (TFA) became resilient while teaching in challenging, high-poverty schools. A secondary purpose of this study was to ascertain how, if at all, the teaching experiences of TFA teachers who stayed in the profession differed…

  7. Fat Quality Influences the Obesogenic Effect of High Fat Diets

    PubMed Central

    Crescenzo, Raffaella; Bianco, Francesca; Mazzoli, Arianna; Giacco, Antonia; Cancelliere, Rosa; di Fabio, Giovanni; Zarrelli, Armando; Liverini, Giovanna; Iossa, Susanna

    2015-01-01

    High fat and/or carbohydrate intake are associated with an elevated risk for obesity and chronic diseases such as diabetes and cardiovascular diseases. The harmful effects of a high fat diet could be different, depending on dietary fat quality. In fact, high fat diets rich in unsaturated fatty acids are considered less deleterious for human health than those rich in saturated fat. In our previous studies, we have shown that rats fed a high fat diet developed obesity and exhibited a decrease in oxidative capacity and an increase in oxidative stress in liver mitochondria. To investigate whether polyunsaturated fats could attenuate the above deleterious effects of high fat diets, energy balance and body composition were assessed after two weeks in rats fed isocaloric amounts of a high-fat diet (58.2% by energy) rich either in lard or safflower/linseed oil. Hepatic functionality, plasma parameters, and oxidative status were also measured. The results show that feeding on safflower/linseed oil diet attenuates the obesogenic effect of high fat diets and ameliorates the blood lipid profile. Conversely, hepatic steatosis and mitochondrial oxidative stress appear to be negatively affected by a diet rich in unsaturated fatty acids. PMID:26580650

  8. Video Snapshots: Creating High-Quality Images from Video Clips.

    PubMed

    Sunkavalli, Kalyan; Joshi, Neel; Kang, Sing Bing; Cohen, Michael F; Pfister, Hanspeter

    2012-11-01

    We describe a unified framework for generating a single high-quality still image ("snapshot") from a short video clip. Our system allows the user to specify the desired operations for creating the output image, such as super resolution, noise and blur reduction, and selection of best focus. It also provides a visual summary of activity in the video by incorporating saliency-based objectives in the snapshot formation process. We show examples on a number of different video clips to illustrate the utility and flexibility of our system.

  9. A comparison of spectral quality in magnetic resonance spectroscopy data acquired with and without a novel EPI-navigated PRESS sequence in school-aged children with fetal alcohol spectrum disorders.

    PubMed

    Hess, Aaron T; Jacobson, Sandra W; Jacobson, Joseph L; Molteno, Christopher D; van der Kouwe, André J W; Meintjes, Ernesta M

    2014-06-01

    Single voxel spectroscopy (SVS) can generate useful information regarding metabolite concentrations provided that the MR signal can be averaged over several minutes during which the subject remains stationary. This requirement can be particularly challenging for children who cannot otherwise be scanned without sedation. To address this problem we developed an EPI volume navigated (vNav) SVS PRESS sequence, which applies real-time head pose (location and orientation), frequency, and first-order B0 shim adjustments. A water-independent preprocessing algorithm removes residual frequency and phase shifts resulting from within-TR movements. We compare results and performance of the standard and vNav PRESS sequences in a sample of 9- to 10-year-olds from a South African cohort of children with fetal alcohol spectrum disorders (FASD) and healthy controls. Magnetic resonance spectroscopy (MRS) data in the deep cerebellar nuclei were initially acquired with the standard PRESS sequence. The children were re-scanned 1 year later with the vNav PRESS sequence. Good quality data were acquired in 73% using the vNav PRESS sequence, compared to only 50% for the standard PRESS sequence. Additionally, tighter linewidths and smaller variances in the measured concentrations were observed. These findings confirm previous reports demonstrating the efficacy of our innovative vNav sequence with healthy volunteers and young children with HIV and expand its application to a school-aged population with FASD-disorders often associated with attention problems and hyperactivity. This study provides the most direct evidence to date regarding degree to which these new methods can improve data quality in research studies employing MRS.

  10. High prevalence of multidrug-resistant Pneumococcal molecular epidemiology network clones among Streptococcus pneumoniae isolates from adult patients with community-acquired pneumonia in Japan.

    PubMed

    Imai, S; Ito, Y; Ishida, T; Hirai, T; Ito, I; Maekawa, K; Takakura, S; Iinuma, Y; Ichiyama, S; Mishima, M

    2009-11-01

    A total of 141 Streptococcus pneumoniae isolates from patients with community-acquired pneumonia were collected from May 2003 through October 2004. The strains were tested for antimicrobial agent susceptibility, serotype and genotype by multilocus sequence typing (MLST) and the presence of the pilus rlrA islet. MLST analysis identified 49 sequence types (STs), of which 19 were novel. eBURST analysis using the MLST database (3773 STs) grouped the isolates into 27 clonal complexes and three singletons. A total of 92 (65.2%) isolates were related to ten of the 43 international Pneumococcal Molecular Epidemiology Network (PMEN) clones; major clones found were multidrug-resistant Netherlands(3)-31 [clonal complex (CC) 180], Taiwan(19F)-14 (CC271), Taiwan(23F)-15 (CC242), and Colombia(23F)-26 (CC138) (the latter new to Asia). We adopted univariate and multiple logistic regression models to identify factors associated with PMEN CCs. Multivariate analysis showed that multidrug resistance (OR 6.3; 95% CI 2.0-22.9), carriage serogroups (OR 7.2; 95% CI 2.5-23.7), prevalence of rlrA (OR 12.6; 95% CI 3.6-59.7) and central nervous system-related disorders (OR 7.7; 95% CI 1.8-48.4) were independently associated with PMEN CCs. Our data indicate that multidrug-resistant PMEN clones are highly prevalent, contributing to the high frequency of resistance to antimicrobial agents in Japan, and suggest that certain predisposing factors in patients contribute to the high frequency of these clones.

  11. Evaluation of Patients with Community-Acquired Pneumonia Caused by Zoonotic Pathogens in an Area with a High Density of Animal Farms.

    PubMed

    Huijskens, E G W; Smit, L A M; Rossen, J W A; Heederik, D; Koopmans, M

    2016-03-01

    Intensive animal farming could potentially lead to outbreaks of infectious diseases. Clinicians are at the forefront of detecting unusual diseases, but the lack of specificity of zoonotic disease symptoms makes this a challenging task. We evaluated patients with community-acquired pneumonia (CAP) with known and unknown aetiology in an area with a high livestock density and a potential association with animal farms in the proximity. Between 2008 and 2009, a period coinciding with a large Q fever outbreak in the Netherlands, patients with CAP were tested for the presence of possible respiratory pathogens. The presence and number of farm animals within 1 km of the patients' home address were assessed using geographic information system (GIS) and were compared between cases and age-matched control subjects. Of 408 patients with CAP, pathogens were detected in 275 (67.4%) patients. The presence of sheep and the number of goats were associated with CAP caused by Coxiella burnetii in a multiple logistic regression model (P < 0.05). CAP with unknown aetiology was not associated with the presence of animal farms (P > 0.10). The use of GIS in combination with aetiology of CAP could be potentially used to target diagnostics and to identify outbreaks of rare zoonotic disease.

  12. Edge electrospinning for high throughput production of quality nanofibers

    NASA Astrophysics Data System (ADS)

    Thoppey, N. M.; Bochinski, J. R.; Clarke, L. I.; Gorga, R. E.

    2011-08-01

    A novel, simple geometry for high throughput electrospinning from a bowl edge is presented that utilizes a vessel filled with a polymer solution and a concentric cylindrical collector. Successful fiber formation is presented for two different polymer systems with differing solution viscosity and solvent volatility. The process of jet initiation, resultant fiber morphology and fiber production rate are discussed for this unconfined feed approach. Under high voltage initiation, the jets spontaneously form directly on the fluid surface and rearrange along the circumference of the bowl to provide approximately equal spacing between spinning sites. Nanofibers currently produced from bowl electrospinning are identical in quality to those fabricated by traditional needle electrospinning (TNE) with a demonstrated ~ 40 times increase in the production rate for a single batch of solution due primarily to the presence of many simultaneous jets. In the bowl electrospinning geometry, the electric field pattern and subsequent effective feed rate are very similar to those parameters found under optimized TNE experiments. Consequently, the electrospinning process per jet is directly analogous to that in TNE and thereby results in the same quality of nanofibers.

  13. Drug discovery from Nature: automated high-quality sample preparation

    PubMed Central

    Thiericke, Ralf

    2000-01-01

    Secondary metabolites from plants, animals and microorganisms have been proven to be an outstanding source for new and innovative drugs and show a striking structural diversity that supplements chemically synthesized compounds or libraries in drug discovery programs. Unfortunately, extracts from natural sources are usually complex mixtures of compounds:: often generated in time consuming and for the most part manual processes. As quality and quantity of the provided samples play a pivotal role in the success of high-throughput screening programs this poses serious problems. In order to make samples of natural origin competitive with synthetic compound libraries, we devised a novel, automated sample preparation procedure based on solid-phase extraction (SPE). By making use of a modified Zymark RapidTrace® SPE workstation an easy-to-handle and effective fractionation method has been developed which allows the generation of highquality samples from natural origin, fulfilling the requirements of an integration into high-throughput screening programs. PMID:18924703

  14. Blueprint for action: steps toward a high-quality, high-value maternity care system.

    PubMed

    Angood, Peter B; Armstrong, Elizabeth Mitchell; Ashton, Diane; Burstin, Helen; Corry, Maureen P; Delbanco, Suzanne F; Fildes, Barbara; Fox, Daniel M; Gluck, Paul A; Gullo, Sue Leavitt; Howes, Joanne; Jolivet, R Rima; Laube, Douglas W; Lynne, Donna; Main, Elliott; Markus, Anne Rossier; Mayberry, Linda; Mitchell, Lynn V; Ness, Debra L; Nuzum, Rachel; Quinlan, Jeffrey D; Sakala, Carol; Salganicoff, Alina

    2010-01-01

    Childbirth Connection hosted a 90th Anniversary national policy symposium, Transforming Maternity Care: A High Value Proposition, on April 3, 2009, in Washington, DC. Over 100 leaders from across the range of stakeholder perspectives were actively engaged in the symposium work to improve the quality and value of U.S. maternity care through broad system improvement. A multi-disciplinary symposium steering committee guided the strategy from its inception and contributed to every phase of the project. The "Blueprint for Action: Steps Toward a High Quality, High Value Maternity Care System", issued by the Transforming Maternity Care Symposium Steering Committee, answers the fundamental question, "Who needs to do what, to, for, and with whom to improve the quality of maternity care over the next five years?" Five stakeholder workgroups collaborated to propose actionable strategies in 11 critical focus areas for moving expeditiously toward the realization of the long term "2020 Vision for a High Quality, High Value Maternity Care System", also published in this issue. Following the symposium these workgroup reports and recommendations were synthesized into the current blueprint. For each critical focus area, the "Blueprint for Action" presents a brief problem statement, a set of system goals for improvement in that area, and major recommendations with proposed action steps to achieve them. This process created a clear sightline to action that if enacted could improve the structure, process, experiences of care, and outcomes of the maternity care system in ways that when anchored in the culture can indeed transform maternity care.

  15. Automated Theorem Proving in High-Quality Software Design

    NASA Technical Reports Server (NTRS)

    Schumann, Johann; Swanson, Keith (Technical Monitor)

    2001-01-01

    The amount and complexity of software developed during the last few years has increased tremendously. In particular, programs are being used more and more in embedded systems (from car-brakes to plant-control). Many of these applications are safety-relevant, i.e. a malfunction of hardware or software can cause severe damage or loss. Tremendous risks are typically present in the area of aviation, (nuclear) power plants or (chemical) plant control. Here, even small problems can lead to thousands of casualties and huge financial losses. Large financial risks also exist when computer systems are used in the area of telecommunication (telephone, electronic commerce) or space exploration. Computer applications in this area are not only subject to safety considerations, but also security issues are important. All these systems must be designed and developed to guarantee high quality with respect to safety and security. Even in an industrial setting which is (or at least should be) aware of the high requirements in Software Engineering, many incidents occur. For example, the Warshaw Airbus crash, was caused by an incomplete requirements specification. Uncontrolled reuse of an Ariane 4 software module was the reason for the Ariane 5 disaster. Some recent incidents in the telecommunication area, like illegal "cloning" of smart-cards of D2GSM handies, or the extraction of (secret) passwords from German T-online users show that also in this area serious flaws can happen. Due to the inherent complexity of computer systems, most authors claim that only a rigorous application of formal methods in all stages of the software life cycle can ensure high quality of the software and lead to real safe and secure systems. In this paper, we will have a look, in how far automated theorem proving can contribute to a more widespread application of formal methods and their tools, and what automated theorem provers (ATPs) must provide in order to be useful.

  16. Improved Detection of Respiratory Pathogens by Use of High-Quality Sputum with TaqMan Array Card Technology.

    PubMed

    Wolff, Bernard J; Bramley, Anna M; Thurman, Kathleen A; Whitney, Cynthia G; Whitaker, Brett; Self, Wesley H; Arnold, Sandra R; Trabue, Christopher; Wunderink, Richard G; McCullers, Jon; Edwards, Kathryn M; Jain, Seema; Winchell, Jonas M

    2017-01-01

    New diagnostic platforms often use nasopharyngeal or oropharyngeal (NP/OP) swabs for pathogen detection for patients hospitalized with community-acquired pneumonia (CAP). We applied multipathogen testing to high-quality sputum specimens to determine if more pathogens can be identified relative to NP/OP swabs. Children (<18 years old) and adults hospitalized with CAP were enrolled over 2.5 years through the Etiology of Pneumonia in the Community (EPIC) study. NP/OP specimens with matching high-quality sputum (defined as ≤10 epithelial cells/low-power field [lpf] and ≥25 white blood cells/lpf or a quality score [q-score] definition of 2+) were tested by TaqMan array card (TAC), a multipathogen real-time PCR detection platform. Among 236 patients with matched specimens, a higher proportion of sputum specimens had ≥1 pathogen detected compared with NP/OP specimens in children (93% versus 68%; P < 0.0001) and adults (88% versus 61%; P < 0.0001); for each pathogen targeted, crossing threshold (CT) values were earlier in sputum. Both bacterial (361 versus 294) and viral detections (245 versus 140) were more common in sputum versus NP/OP specimens, respectively, in both children and adults. When available, high-quality sputum may be useful for testing in hospitalized CAP patients.

  17. Acquired hypofibrinogenemia: current perspectives

    PubMed Central

    Besser, Martin W; MacDonald, Stephen G

    2016-01-01

    Acquired hypofibrinogenemia is most frequently caused by hemodilution and consumption of clotting factors. The aggressive replacement of fibrinogen has become one of the core principles of modern management of massive hemorrhage. The best method for determining the patient’s fibrinogen level remains controversial, and particularly in acquired dysfibrinogenemia, could have major therapeutic implications depending on which quantification method is chosen. This review introduces the available laboratory and point-of-care methods and discusses the relative advantages and limitations. It also discusses current strategies for the correction of hypofibrinogenemia. PMID:27713652

  18. Community-acquired pneumonia.

    PubMed

    Falguera, M; Ramírez, M F

    2015-11-01

    This article not only reviews the essential aspects of community-acquired pneumonia for daily clinical practice, but also highlights the controversial issues and provides the newest available information. Community-acquired pneumonia is considered in a broad sense, without excluding certain variants that, in recent years, a number of authors have managed to delineate, such as healthcare-associated pneumonia. The latter form is nothing more than the same disease that affects more frail patients, with a greater number of risk factors, both sharing an overall common approach.

  19. Generation of High-Quality SWATH(®) Acquisition Data for Label-free Quantitative Proteomics Studies Using TripleTOF(®) Mass Spectrometers.

    PubMed

    Schilling, Birgit; Gibson, Bradford W; Hunter, Christie L

    2017-01-01

    Data-independent acquisition is a powerful mass spectrometry technique that enables comprehensive MS and MS/MS analysis of all detectable species, providing an information rich data file that can be mined deeply. Here, we describe how to acquire high-quality SWATH(®) Acquisition data to be used for large quantitative proteomic studies. We specifically focus on using variable sized Q1 windows for acquisition of MS/MS data for generating higher specificity quantitative data.

  20. Environmental Quality Assessment of Built Areas with High Vacancy

    NASA Astrophysics Data System (ADS)

    Jiang, Y.; Yuan, Y.; Neale, A. C.

    2015-12-01

    Around the world, many urban areas are challenged by vacant and abandoned residential and business property. High vacancy areas have often been associated with increasing public safety problems and declining property values and subsequent tax base. High vacancy can lead to visible signs of city decline and significant barriers to the revitalization of cities. Addressing the problem of vacancy requires knowledge of vacancy patterns and their possible contributing factors. In this study, we evaluated the ten year (2005-2015) urban environmental changes for some high vacancy areas. Social and economic variables derived from U.S. census data such as non-white population, employment rate, housing price, and environmental variables derived from National Land Cover Data such as land cover and impervious area, were used as the basis for analysis. Correlation analysis and principle components analysis were performed at the Census Block Group level. Three components were identified and interpreted as economic status, urbanness, and greenness. A synthetic Urban Environmental Quality (UEQ) index was developed by integrating the three principle components according to their weights. Comparisons of the UEQ indices between the 2005 and 2015 in the increasingly high vacancy area provided useful information for investigating the possible associations between social, economic, and environmental factors, and the vacancy status. This study could provide useful information for understanding the complex issues leading to vacancy and facilitating future rehabilitation of vacant urban area.

  1. Unusually high soil nitrogen oxide emissions influence air quality in a high-temperature agricultural region

    PubMed Central

    Oikawa, P. Y.; Ge, C.; Wang, J.; Eberwein, J. R.; Liang, L. L.; Allsman, L. A.; Grantz, D. A.; Jenerette, G. D.

    2015-01-01

    Fertilized soils have large potential for production of soil nitrogen oxide (NOx=NO+NO2), however these emissions are difficult to predict in high-temperature environments. Understanding these emissions may improve air quality modelling as NOx contributes to formation of tropospheric ozone (O3), a powerful air pollutant. Here we identify the environmental and management factors that regulate soil NOx emissions in a high-temperature agricultural region of California. We also investigate whether soil NOx emissions are capable of influencing regional air quality. We report some of the highest soil NOx emissions ever observed. Emissions vary nonlinearly with fertilization, temperature and soil moisture. We find that a regional air chemistry model often underestimates soil NOx emissions and NOx at the surface and in the troposphere. Adjusting the model to match NOx observations leads to elevated tropospheric O3. Our results suggest management can greatly reduce soil NOx emissions, thereby improving air quality. PMID:26556236

  2. Unusually high soil nitrogen oxide emissions influence air quality in a high-temperature agricultural region.

    PubMed

    Oikawa, P Y; Ge, C; Wang, J; Eberwein, J R; Liang, L L; Allsman, L A; Grantz, D A; Jenerette, G D

    2015-11-10

    Fertilized soils have large potential for production of soil nitrogen oxide (NOx=NO+NO2), however these emissions are difficult to predict in high-temperature environments. Understanding these emissions may improve air quality modelling as NOx contributes to formation of tropospheric ozone (O3), a powerful air pollutant. Here we identify the environmental and management factors that regulate soil NOx emissions in a high-temperature agricultural region of California. We also investigate whether soil NOx emissions are capable of influencing regional air quality. We report some of the highest soil NOx emissions ever observed. Emissions vary nonlinearly with fertilization, temperature and soil moisture. We find that a regional air chemistry model often underestimates soil NOx emissions and NOx at the surface and in the troposphere. Adjusting the model to match NOx observations leads to elevated tropospheric O3. Our results suggest management can greatly reduce soil NOx emissions, thereby improving air quality.

  3. Wind resource quality affected by high levels of renewables

    DOE PAGES

    Diakov, Victor

    2015-06-17

    For solar photovoltaic (PV) and wind resources, the capacity factor is an important parameter describing the quality of the resource. As the share of variable renewable resources (such as PV and wind) on the electric system is increasing, so does curtailment (and the fraction of time when it cannot be avoided). At high levels of renewable generation, curtailments effectively change the practical measure of resource quality from capacity factor to the incremental capacity factor. The latter accounts only for generation during hours of no curtailment and is directly connected with the marginal capital cost of renewable generators for a givenmore » level of renewable generation during the year. The Western U.S. wind generation is analyzed hourly for a system with 75% of annual generation from wind, and it is found that the value for the system of resources with equal capacity factors can vary by a factor of 2, which highlights the importance of using the incremental capacity factor instead. Finally, the effect is expected to be more pronounced in smaller geographic areas (or when transmission limitations imposed) and less pronounced at lower levels of renewable energy in the system with less curtailment.« less

  4. Wind resource quality affected by high levels of renewables

    SciTech Connect

    Diakov, Victor

    2015-06-17

    For solar photovoltaic (PV) and wind resources, the capacity factor is an important parameter describing the quality of the resource. As the share of variable renewable resources (such as PV and wind) on the electric system is increasing, so does curtailment (and the fraction of time when it cannot be avoided). At high levels of renewable generation, curtailments effectively change the practical measure of resource quality from capacity factor to the incremental capacity factor. The latter accounts only for generation during hours of no curtailment and is directly connected with the marginal capital cost of renewable generators for a given level of renewable generation during the year. The Western U.S. wind generation is analyzed hourly for a system with 75% of annual generation from wind, and it is found that the value for the system of resources with equal capacity factors can vary by a factor of 2, which highlights the importance of using the incremental capacity factor instead. Finally, the effect is expected to be more pronounced in smaller geographic areas (or when transmission limitations imposed) and less pronounced at lower levels of renewable energy in the system with less curtailment.

  5. Low-pathogenicity Mycoplasma spp. alter human monocyte and macrophage function and are highly prevalent among patients with ventilator-acquired pneumonia

    PubMed Central

    Nolan, T J; Gadsby, N J; Templeton, K E; McMullan, R; McKenna, J P; Rennie, J; Robb, C T; Walsh, T S; Rossi, A G; Conway Morris, A; Simpson, A J

    2016-01-01

    Background Ventilator-acquired pneumonia (VAP) remains a significant problem within intensive care units (ICUs). There is a growing recognition of the impact of critical-illness-induced immunoparesis on the pathogenesis of VAP, but the mechanisms remain incompletely understood. We hypothesised that, because of limitations in their routine detection, Mycoplasmataceae are more prevalent among patients with VAP than previously recognised, and that these organisms potentially impair immune cell function. Methods and setting 159 patients were recruited from 12 UK ICUs. All patients had suspected VAP and underwent bronchoscopy and bronchoalveolar lavage (BAL). VAP was defined as growth of organisms at >104 colony forming units per ml of BAL fluid on conventional culture. Samples were tested for Mycoplasmataceae (Mycoplasma and Ureaplasma spp.) by PCR, and positive samples underwent sequencing for speciation. 36 healthy donors underwent BAL for comparison. Additionally, healthy donor monocytes and macrophages were exposed to Mycoplasma salivarium and their ability to respond to lipopolysaccharide and undertake phagocytosis was assessed. Results Mycoplasmataceae were found in 49% (95% CI 33% to 65%) of patients with VAP, compared with 14% (95% CI 9% to 25%) of patients without VAP. Patients with sterile BAL fluid had a similar prevalence to healthy donor BAL fluid (10% (95% CI 4% to 20%) vs 8% (95% CI 2% to 22%)). The most common organism identified was M. salivarium. Blood monocytes from healthy volunteers incubated with M. salivarium displayed an impaired TNF-α response to lipopolysaccharide (p=0.0003), as did monocyte-derived macrophages (MDMs) (p=0.024). MDM exposed to M. salivarium demonstrated impaired phagocytosis (p=0.005). Discussion and conclusions This study demonstrates a high prevalence of Mycoplasmataceae among patients with VAP, with a markedly lower prevalence among patients with suspected VAP in whom subsequent cultures refuted the diagnosis. The most

  6. Recruiting and retaining high-quality teachers in rural areas.

    PubMed

    Monk, David H

    2007-01-01

    In examining recruitment and retention of teachers in rural areas, David Monk begins by noting the numerous possible characteristics of rural communities--small size, sparse settlement, distance from population concentrations, and an economic reliance on agricultural industries that are increasingly using seasonal and immigrant workers to minimize labor costs. Many, though not all, rural areas, he says, are seriously impoverished. Classes in rural schools are relatively small, and teachers tend to report satisfaction with their work environments and relatively few problems with discipline. But teacher turnover is often high, and hiring can be difficult. Monk observes that rural schools have a below-average share of highly trained teachers. Compensation in rural schools tends to be low, perhaps because of a lower fiscal capacity in rural areas, thus complicating efforts to attract and retain teachers. Several student characteristics, including relatively large shares of students with special needs and with limited English skills and lower shares of students attending college, can also make it difficult to recruit and retain high-quality teachers. Other challenges include meeting the needs of highly mobile children of low-income migrant farm workers. With respect to public policy, Monk asserts a need to focus on a subcategory of what might be called hard-to-staff rural schools rather than to develop a blanket set of policies for all rural schools. In particular, he recommends a focus on such indicators as low teacher qualifications, teaching in fields far removed from the area of training, difficulty in hiring, high turnover, a lack of diversity among teachers in the school, and the presence of migrant farm workers' children. Successful efforts to stimulate economic growth in these areas would be highly beneficial. He also calls attention to the potential for modern telecommunication and computing technologies to offset some of the drawbacks associated with teaching

  7. A high throughput DNA extraction method with high yield and quality

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Background: Preparation of large quantity and high quality genomic DNA from a large number of plant samples is a major bottleneck for most genetic and genomic analyses, such as, genetic mapping, TILLING (Targeting Induced Local Lesion IN Genome), and next-generation sequencing directly from sheared ...

  8. High-frequency and high-quality silicon carbide optomechanical microresonators

    PubMed Central

    Lu, Xiyuan; Lee, Jonathan Y.; Lin, Qiang

    2015-01-01

    Silicon carbide (SiC) exhibits excellent material properties attractive for broad applications. We demonstrate the first SiC optomechanical microresonators that integrate high mechanical frequency, high mechanical quality, and high optical quality into a single device. The radial-breathing mechanical mode has a mechanical frequency up to 1.69 GHz with a mechanical Q around 5500 in atmosphere, which corresponds to a fm · Qm product as high as 9.47 × 1012 Hz. The strong optomechanical coupling allows us to efficiently excite and probe the coherent mechanical oscillation by optical waves. The demonstrated devices, in combination with the superior thermal property, chemical inertness, and defect characteristics of SiC, show great potential for applications in metrology, sensing, and quantum photonics, particularly in harsh environments that are challenging for other device platforms. PMID:26585637

  9. (Collection of high quality acoustical records for honeybees)

    SciTech Connect

    Kerr, H.T.; Buchanan, M.E.

    1987-02-19

    High quality acoustical data records were collected for both European and Africanized honeybees under various field conditions. This data base was needed for more rigorous evaluation of a honeybee identification technique previously developed by the travelers from preliminary data sets. Laboratory-grade recording equipment was used to record sounds made by honeybees in and near their nests and during foraging flights. Recordings were obtained from European and Africanized honeybees in the same general environment. Preliminary analyses of the acoustical data base clearly support the general identification algorithm: Africanized honeybee noise has significantly higher frequency content than does European honeybee noise. As this algorithm is refined, it may result in the development of a simple field-portable device for identifying subspecies of honeybees. Further, the honeybee's acoustical signals appear to be correlated with specific colony conditions. Understanding these variations may have enormous benefit for entomologists and for the beekeeping industry.

  10. High quality optically polished aluminum mirror and process for producing

    NASA Technical Reports Server (NTRS)

    Lyons, III, James J. (Inventor); Zaniewski, John J. (Inventor)

    2005-01-01

    A new technical advancement in the field of precision aluminum optics permits high quality optical polishing of aluminum monolith, which, in the field of optics, offers numerous benefits because of its machinability, lightweight, and low cost. This invention combines diamond turning and conventional polishing along with india ink, a newly adopted material, for the polishing to accomplish a significant improvement in surface precision of aluminum monolith for optical purposes. This invention guarantees the precise optical polishing of typical bare aluminum monolith to surface roughness of less than about 30 angstroms rms and preferably about 5 angstroms rms while maintaining a surface figure accuracy in terms of surface figure error of not more than one-fifteenth of wave peak-to-valley.

  11. High quality optically polished aluminum mirror and process for producing

    NASA Technical Reports Server (NTRS)

    Lyons, III, James J. (Inventor); Zaniewski, John J. (Inventor)

    2002-01-01

    A new technical advancement in the field of precision aluminum optics permits high quality optical polishing of aluminum monolith, which, in the field of optics, offers numerous benefits because of its machinability, lightweight, and low cost. This invention combines diamond turning and conventional polishing along with india ink, a newly adopted material, for the polishing to accomplish a significant improvement in surface precision of aluminum monolith for optical purposes. This invention guarantees the precise optical polishing of typical bare aluminum monolith to surface roughness of less than about 30 angstroms rms and preferably about 5 angstroms rms while maintaining a surface figure accuracy in terms of surface figure error of not more than one-fifteenth of wave peak-to-valley.

  12. Sequential interactive evolution for finding high-quality topologies

    NASA Astrophysics Data System (ADS)

    Avigad, Gideon; Salomon, Shaul; Knopf, George

    2015-10-01

    Finding a diverse set of high-quality (HQ) topologies for a single-objective optimization problem using an evolutionary computation algorithm can be difficult without a reliable measure that adequately describes the dissimilarity between competing topologies. In this article, a new approach for enhancing diversity among HQ topologies for engineering design applications is proposed. The technique initially selects one HQ solution and then searches for alternative HQ solutions by performing an optimization of the original objective and its dissimilarity with respect to the previously found solution. The proposed multi-objective optimization approach interactively amalgamates user articulated preferences with an evolutionary search so as sequentially to produce a set of diverse HQ solutions to a single-objective problem. For enhancing diversity, a new measure is suggested and an approach to reducing its computational time is studied and implemented. To illustrate the technique, a series of studies involving different topologies represented as bitmaps is presented.

  13. High Resolution Projection of Future Air Quality in South Asia

    NASA Astrophysics Data System (ADS)

    Kumar, R.; Barth, M. C.; Pfister, G.; Lamarque, J. F.; Walters, S.; Naja, M. K.; Ghude, S. D.

    2015-12-01

    About one seventh of the world's population living in South Asia faces the risk of severe air pollution due to high anthropogenic emissions of air pollutants. Recent studies have shown that exposure to present day air pollution in South Asia is sufficient enough to reduce the lifespan of about 660 million people by about 3 years, destroy food that can feed about 94 million poor people and cause economic loss of several billion dollars. This problem may worsen in the future as anthropogenic emissions are expected to increase due to rapid economic growth in South Asia, and climate change is expected to lead to atmospheric conditions conducive for the production and accumulation of air pollutants. In order to predict how air quality will change in South Asia in future (2050), we are conducting high resolution air quality simulations for the present day (2005-2014) and future (2046-2055) time periods using the Nested Regional Climate Model coupled with Chemistry (NRCM-Chem). The model domain covers entire South Asia at a horizontal grid spacing of 60 km with a nested domain over the densely populated and polluted Indo-Gangetic Plain region at a horizontal grid spacing of 12 km. The model results are being evaluated with available in situ and satellite based observations and the evaluation results show that NRCM-Chem model is able to capture several important features of the observed spatial and temporal distribution of key meteorological parameters and air pollutants. Initial model results show that annual average surface ozone and PM2.5 concentrations may increase by up to 15 ppbv and 25 μg m-3, respectively with highest increase in the Indo-Gangetic Plain.

  14. Acquired Brain Injury Program.

    ERIC Educational Resources Information Center

    Schwartz, Stacey Hunter

    This paper reviews the Acquired Brain Injury (ABI) Program at Coastline Community College (California). The ABI Program is a two-year, for-credit educational curriculum designed to provide structured cognitive retraining for adults who have sustained an ABI due to traumatic (such as motor vehicle accident or fall) or non-traumatic(such as…

  15. High power, high beam quality solid state lasers for materials processing applications

    SciTech Connect

    Hackel, L.A.; Dane, C.B.; Hermann, M.R.

    1994-08-01

    The Laser Science and Technology Department at Lawrence Livermore National Laboratory is developing solid state lasers with high average power and high beam quality. Specific systems include a laser to generate 10 to 14 {angstrom} x-rays for proximity print lithography, a 400 mJ, 500 Hz laser for 130 {angstrom} projection lithography and unique systems for speckle imaging, laser radars and medical treatments.

  16. Criteria for High Quality Biology Teaching: An Analysis

    ERIC Educational Resources Information Center

    Tasci, Guntay

    2015-01-01

    This study aims to analyze the process under which biology lessons are taught in terms of teaching quality criteria (TQC). Teaching quality is defined as the properties of efficient teaching and is considered to be the criteria used to measure teaching quality both in general and specific to a field. The data were collected through classroom…

  17. Total Quality Management: A Management Philosophy for Providing High Quality Construction

    DTIC Science & Technology

    1992-01-01

    of products and service during the construction process. Under the philosophy of TQM, we build quality into the finished product....TQM method to ensure top quality production. It will be shown why I believe TQM or a variation thereof is the best method for controlling the quality

  18. Low-quality birds do not display high-quality signals: The cysteine-pheomelanin mechanism of honesty

    PubMed Central

    Galván, Ismael; Wakamatsu, Kazumasa; Camarero, Pablo R; Mateo, Rafael; Alonso-Alvarez, Carlos

    2015-01-01

    The mechanisms that make that the costs of producing high-quality signals are unaffordable to low-quality signalers are a current issue in animal communication. The size of the melanin-based bib of male house sparrows Passer domesticus honestly signals quality. We induced the development of new bibs while treating males with buthionine-sulfoximine (BSO), a substance that depletes the levels of the antioxidant glutathione (GSH) and the amino acid cysteine, two elements that switch melanogenesis from eumelanin to pheomelanin. Final bib size is negatively related to pheomelanin levels in the bib feathers. BSO reduced cysteine and GSH levels in all birds, but improved phenotypes (bibs larger than controls) were only expressed by high-quality birds (BSO birds with largest bibs initially). Negative associations between final bib size and cysteine levels in erythrocytes, and between pheomelanin and cysteine levels, were observed in high-quality birds only. These findings suggest that a mechanism uncoupling pheomelanin and cysteine levels may have evolved in low-quality birds to avoid producing bibs of size not corresponding to their quality and greater relative costs. Indeed, greater oxidative stress in cells was not observed in low-quality birds. This may represent the first mechanism maintaining signal honesty without producing greater relative costs on low-quality signalers. PMID:25330349

  19. Effect of high pressure-high temperature process on meat product quality

    NASA Astrophysics Data System (ADS)

    Duranton, Frédérique; Marée, Elvire; Simonin, Hélène; Chéret, Romuald; de Lamballerie, Marie

    2011-03-01

    High pressure/high temperature (HPHT) processing is an innovative way to sterilize food and has been proposed as an alternative to conventional retorting. By using elevated temperatures and adiabatic compression, it allows the inactivation of vegetative microorganisms and pathogen spores. Even though the microbial inactivation has been widely studied, the effect of such process on sensorial attributes of food products, especially meat products, remains rare. The aim of this study was to investigate the potential of using HPHT process (500 MPa/115 °C) instead of conventional retorting to stabilize Toulouse sausages while retaining high organoleptic quality. The measurements of texture, color, water-holding capacity and microbial stability were investigated. It was possible to manufacture stable products at 500 MPa/115 °C/30 min. However, in these conditions, no improvement of the quality was found compared with conventional retorting.

  20. High-quality frame-synchronization for satellite video signal transmission

    NASA Astrophysics Data System (ADS)

    Kubota, Shuji; Morikura, Masahiro; Kato, Shuzo

    1995-01-01

    A high-quality frame-synchronizer for video signal switching and freezing is proposed. In order to realize high-quality frame-synchronization, a novel high-speed and high-definition 11 bit analog-to-digital (A/D) converter which achieves the quite high unweighted S/N ratio performance of 63 dB is developed. It provides synchronized video signal switching by field freezing for high-quality video signal transmission.

  1. Nursing home-acquired pneumonia.

    PubMed

    El Solh, Ali A

    2009-02-01

    Nursing home-acquired pneumonia (NHAP) was first described in 1978. Since then there has been much written regarding NHAP and its management despite the lack of well-designed studies in this patient population. The most characteristic features of patients with NHAP are the atypical presentation, which may lead to delay in diagnosis and therapy. The microbial etiology of pneumonia encompasses a wide spectrum that spans microbes recovered from patients with community-acquired pneumonia to organisms considered specific only to nosocomial settings. Decision to transfer a nursing home patient to an acute care facility depends on a host of factors, which include the level of staffing available at the nursing home, patients' advance directives, and complexity of treatment. The presence of risk factors for multidrug-resistant pathogens dictates approach to therapy. Prevention remains the cornerstone of reducing the incidence of disease. Despite the advance in medical services, mortality from NHAP remains high.

  2. High-quality observation of surface imperviousness for urban runoff modelling using UAV imagery

    NASA Astrophysics Data System (ADS)

    Tokarczyk, P.; Leitao, J. P.; Rieckermann, J.; Schindler, K.; Blumensaat, F.

    2015-10-01

    Modelling rainfall-runoff in urban areas is increasingly applied to support flood risk assessment, particularly against the background of a changing climate and an increasing urbanization. These models typically rely on high-quality data for rainfall and surface characteristics of the catchment area as model input. While recent research in urban drainage has been focusing on providing spatially detailed rainfall data, the technological advances in remote sensing that ease the acquisition of detailed land-use information are less prominently discussed within the community. The relevance of such methods increases as in many parts of the globe, accurate land-use information is generally lacking, because detailed image data are often unavailable. Modern unmanned aerial vehicles (UAVs) allow one to acquire high-resolution images on a local level at comparably lower cost, performing on-demand repetitive measurements and obtaining a degree of detail tailored for the purpose of the study. In this study, we investigate for the first time the possibility of deriving high-resolution imperviousness maps for urban areas from UAV imagery and of using this information as input for urban drainage models. To do so, an automatic processing pipeline with a modern classification method is proposed and evaluated in a state-of-the-art urban drainage modelling exercise. In a real-life case study (Lucerne, Switzerland), we compare imperviousness maps generated using a fixed-wing consumer micro-UAV and standard large-format aerial images acquired by the Swiss national mapping agency (swisstopo). After assessing their overall accuracy, we perform an end-to-end comparison, in which they are used as an input for an urban drainage model. Then, we evaluate the influence which different image data sources and their processing methods have on hydrological and hydraulic model performance. We analyse the surface runoff of the 307 individual subcatchments regarding relevant attributes, such as peak

  3. Image quality and high contrast improvements on VLT/NACO

    NASA Astrophysics Data System (ADS)

    Girard, Julien H. V.; O'Neal, Jared; Mawet, Dimitri; Kasper, Markus; Zins, Gérard; Neichel, Benoît; Kolb, Johann; Christiaens, Valentin; Tourneboeuf, Martin

    2012-07-01

    NACO is the famous and versatile diffraction limited NIR imager and spectrograph at the VLT with which ESO celebrated 10 years of Adaptive Optics. Since two years a substantial effort has been put in understanding and fixing issues that directly affect the image quality and the high contrast performances of the instrument. Experiments to compensate the non-common-path aberrations and recover the highest possible Strehl ratios have been carried out successfully and a plan is hereafter described to perform such measurements regularly. The drift associated to pupil tracking since 2007 was fixed in october 2011. NACO is therefore even more suited for high contrast imaging and can be used with coronagraphic masks in the image plane. Some contrast measurements are shown and discussed. The work accomplished on NACO will serve as reference for the next generation instruments on the VLT, especially the ones working at the diffraction limit and making use of angular differential imaging (i.e. SPHERE, VISIR, and possibly ERIS).

  4. Plasmonic CROWs for Tunable Dispersion and High Quality Cavity Modes

    NASA Astrophysics Data System (ADS)

    Wood, John J.; Lafone, Lucas; Hamm, Joachim M.; Hess, Ortwin; Oulton, Rupert F.

    2015-12-01

    Coupled resonator optical waveguides (CROWs) have the potential to revolutionise integrated optics, to slow-light and enhance linear and non-linear optical phenomena. Here we exploit the broad resonances and subwavelength nature of localized surface plasmons in a compact CROW design where plasmonic nanoparticles are side coupled to a dielectric waveguide. The plasmonic CROW features a low loss central mode with a highly tunable dispersion, that avoids coupling to the plasmonic nanoparticles close to the band-edge. We show that this low loss character is preserved in finite plasmonic CROWs giving rise to Fabry-Perot type resonances that have high quality factors of many thousands, limited only by the CROW length. Furthermore we demonstrate that the proposed CROW design is surprisingly robust to disorder. By varying the geometric parameters one can not only reduce the losses into dissipative or radiative channels but also control the outcoupling of energy to the waveguide. The ability to minimise loss in plasmonic CROWs while maintaining dispersion provides an effective cavity design for chip-integrated laser devices and applications in linear and non-linear nano-photonics.

  5. High-Quality Seismic Observations of Sonic Booms

    NASA Technical Reports Server (NTRS)

    Wurman, Gilead; Haering, Edward A., Jr.; Price, Michael J.

    2011-01-01

    The SonicBREWS project (Sonic Boom Resistant Earthquake Warning Systems) is a collaborative effort between Seismic Warning Systems, Inc. and NASA Dryden Flight Research Center. This project aims to evaluate the effects of sonic booms on Earthquake Warning Systems in order to prevent such systems from experiencing false alarms due to sonic booms. The airspace above the Antelope Valley, California includes the High Altitude Supersonic Corridor and the Black Mountain Supersonic Corridor. These corridors are among the few places in the US where supersonic flight is permitted, and sonic booms are commonplace in the Antelope Valley. One result of this project is a rich dataset of high-quality accelerometer records of sonic booms which can shed light on the interaction between these atmospheric phenomena and the solid earth. Nearly 100 sonic booms were recorded with low-noise triaxial MEMS accelerometers recording 1000 samples per second. The sonic booms had peak overpressures ranging up to approximately 10 psf and were recorded in three flight series in 2010 and 2011. Each boom was recorded with up to four accelerometers in various array configurations up to 100 meter baseline lengths, both in the built environment and the free field. All sonic booms were also recorded by nearby microphones. We present the results of the project in terms of the potential for sonic-boom-induced false alarms in Earthquake Warning Systems, and highlight some of the interesting features of the dataset.

  6. Plasmonic CROWs for Tunable Dispersion and High Quality Cavity Modes

    PubMed Central

    Wood, John J.; Lafone, Lucas; Hamm, Joachim M.; Hess, Ortwin; Oulton, Rupert F.

    2015-01-01

    Coupled resonator optical waveguides (CROWs) have the potential to revolutionise integrated optics, to slow-light and enhance linear and non-linear optical phenomena. Here we exploit the broad resonances and subwavelength nature of localized surface plasmons in a compact CROW design where plasmonic nanoparticles are side coupled to a dielectric waveguide. The plasmonic CROW features a low loss central mode with a highly tunable dispersion, that avoids coupling to the plasmonic nanoparticles close to the band-edge. We show that this low loss character is preserved in finite plasmonic CROWs giving rise to Fabry-Perot type resonances that have high quality factors of many thousands, limited only by the CROW length. Furthermore we demonstrate that the proposed CROW design is surprisingly robust to disorder. By varying the geometric parameters one can not only reduce the losses into dissipative or radiative channels but also control the outcoupling of energy to the waveguide. The ability to minimise loss in plasmonic CROWs while maintaining dispersion provides an effective cavity design for chip-integrated laser devices and applications in linear and non-linear nano-photonics. PMID:26631579

  7. A Novel Process to Synthesize High-Quality Ferrovanadium Nitride

    NASA Astrophysics Data System (ADS)

    Wu, Yue-Dong; Zhang, Guo-Hua; Chou, Kuo-Chih

    2016-12-01

    In the present work, high-quality ferrovanadium nitride, which has a relative high nitrogen content and a low carbon content, has been prepared by roasting the mixture of vanadium pentoxide, carbon, and ferric oxide under N2 atmosphere in the temperature range from 1673 K to 1873 K (1400 °C to 1600 °C). The effects of carbon addition, reaction temperature, and heat treatment process were discussed. It was found that the carbon addition had a great effect on the nitrogen content and residual carbon, and the optimum carbon content was established to obtain the maximum nitrogen content and low carbon content. The reaction temperature in the range from 1673 K to 1873 K (1400 °C to 1600 °C) has a smaller effect on the final nitrogen content, and it also affects the degree of agglomeration of particles, which were observed by scanning electron microscope. From the results of thermodynamic calculation, energy-dispersive spectroscopy (EDS), and X-ray diffraction (XRD), it was deduced that the reaction sequence of V2O5 with N2 from 1673 K to 1873 K (1400 °C to 1600 °C) was V2O5 → VO2 → V2O3 → V(N, C, O) → V(N, C). There is a little solid solubility of carbon in the final product VN.

  8. Effects of harvesting methods on foreign matter content, fiber quality, and yarn quality from irrigated cotton on the high plains.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Harvest treatments were compared for a variety of cotton commonly grown on the High Plains of Texas. Foreign matter, fiber quality, and yarn quality were compared for cotton harvested using a spindle picker, a brush-roll stripper with a field cleaner, and the same stripper harvester without a field ...

  9. Hospital-acquired thrombocytopenia.

    PubMed

    McMahon, Christine M; Cuker, Adam

    2014-10-01

    The development of thrombocytopenia is common in hospitalized patients and is associated with increased mortality. Frequent and important causes of thrombocytopenia in hospitalized patients include etiologies related to the underlying illness for which the patient is admitted, such as infection and disseminated intravascular coagulation, and iatrogenic etiologies such as drug-induced immune thrombocytopenia, heparin-induced thrombocytopenia, posttransfusion purpura, hemodilution, major surgery, and extracorporeal circuitry. This review presents a brief discussion of the pathophysiology, distinguishing clinical features, and management of these etiologies, and provides a diagnostic approach to hospital-acquired thrombocytopenia that considers the timing and severity of the platelet count fall, the presence of hemorrhage or thrombosis, the clinical context, and the peripheral blood smear. This approach may offer guidance to clinicians in distinguishing among the various causes of hospital-acquired thrombocytopenia and providing management appropriate to the etiology.

  10. Desmosomes in acquired disease

    PubMed Central

    Stahley, Sara N.; Kowalczyk, Andrew P.

    2015-01-01

    Desmosomes are cell-cell junctions that mediate adhesion and couple the intermediate filament cytoskeleton to sites of cell-cell contact. This architectural arrangement functions to integrate adhesion and cytoskeletal elements of adjacent cells. The importance of this robust adhesion system is evident in numerous human diseases, both inherited and acquired, that occur when desmosome function is compromised. This review focuses on autoimmune and infectious diseases that impair desmosome function. In addition, we discuss emerging evidence that desmosomal genes are often misregulated in cancer. The emphasis of our discussion is placed on how human diseases inform our understanding of basic desmosome biology, and in turn, how fundamental advances in the cell biology of desmosomes may lead to new treatments for acquired diseases of the desmosome. PMID:25795143

  11. Desmosomes in acquired disease.

    PubMed

    Stahley, Sara N; Kowalczyk, Andrew P

    2015-06-01

    Desmosomes are cell-cell junctions that mediate adhesion and couple the intermediate filament cytoskeleton to sites of cell-cell contact. This architectural arrangement integrates adhesion and cytoskeletal elements of adjacent cells. The importance of this robust adhesion system is evident in numerous human diseases, both inherited and acquired, which occur when desmosome function is compromised. This review focuses on autoimmune and infectious diseases that impair desmosome function. In addition, we discuss emerging evidence that desmosomal genes are often misregulated in cancer. The emphasis of our discussion is placed on the way in which human diseases can inform our understanding of basic desmosome biology and in turn, the means by which fundamental advances in the cell biology of desmosomes might lead to new treatments for acquired diseases of the desmosome.

  12. Imported acquired immunodeficiency syndrome-related histoplasmosis in metropolitan France: a comparison of pre-highly active anti-retroviral therapy and highly active anti-retroviral therapy eras.

    PubMed

    Peigne, Vincent; Dromer, Françoise; Elie, Caroline; Lidove, Olivier; Lortholary, Olivier

    2011-11-01

    Histoplasma capsulatum var. capsulatum infection is rare outside disease-endemic areas. Clinical presentation and outcome of acquired immunodeficiency syndrome-related histoplasmosis are unknown in non-endemic areas with wide access to highly active anti-retroviral therapy (HAART). Retrospective analysis of cases recorded at the French National Reference Center for Mycoses and Antifungals during two decades: pre-HAART (1985-1994) and HAART (1997-2006). Clinical features and outcome of all adults with proven acquired immunodeficiency syndrome-related histoplasmosis were compared between the two periods. One hundred four patients were included (40 during the pre-HAART era and 64 during the HAART era). Diagnosis was established a mean of 62 days after onset of symptoms. One-year overall mortality rates decreased from 53% (pre-HAART era) to 22% (HAART era). Diagnosis during the pre-HAART era and an older age were the only independent factors associated with death. Histoplasmosis is a rare invasive fungal infection outside disease-endemic areas. Its prognosis improved significantly during the HAART era.

  13. Reducing the cycle time of cementing processes for high quality doublets

    NASA Astrophysics Data System (ADS)

    Wilde, C.; Hahne, F.; Langehanenberg, P.; Heinisch, J.

    2015-09-01

    For the manufacturing of high performance optical systems, centered alignment of the optical surfaces within the assembly is becoming increasingly important. In this contribution, we will present a system for the automated alignment of optical surfaces for the high-throughput manufacturing of cemented doublets (and triplets) with optimized imaging performance. First of all, different concepts for the alignment of doublets etc. are discussed. Standard methods for cementing evaluate mechanical features, such as the outer barrel of one element as reference axis. Using this procedure the optical performance of the assembly that can be achieved is limited by imperfections in the collinearity of the element's barrel axis and its optical axis. Instead, using the optical axis of the bottom element as target axis opens up perspectives for the production of multiplets with perfect symmetric imaging performance. For this concept, all three center of curvature positions of the optical surfaces are measured. Then, the top surface is aligned to the bottom element's optical axis using high-precision actuators. In order to increase the throughput of this procedure, the system is equipped with a novel measurement head that acquires autocollimation images of all three surfaces of a doublet at the same time. Thus, the positions of all surfaces are measured simultaneously during just a single rotation, avoiding both additional rotations and focus movements. Using this approach, cycle times can significantly be reduced from an average of 1 min to less than 10 seconds (w/o curing time). The system is reconfigurable in order to support a wide range of sample designs and enables cementing of high quality optics with centering errors below 2 μm.

  14. Systems and processes that ensure high quality care.

    PubMed

    Bassett, Sally; Westmore, Kathryn

    2012-10-01

    This is the second in a series of articles examining the components of good corporate governance. It considers how the structures and processes for quality governance can affect an organisation's ability to be assured about the quality of care. Complex information systems and procedures can lead to poor quality care, but sound structures and processes alone are insufficient to ensure good governance, and behavioural factors play a significant part in making sure that staff are enabled to provide good quality care. The next article in this series looks at how the information reporting of an organisation can affect its governance.

  15. Expressive Electronic Journal Writing: Freedom of Communication for Survivors of Acquired Brain Injury

    ERIC Educational Resources Information Center

    Fraas, Michael; Balz, Magdalen A.

    2008-01-01

    In addition to the impaired ability to effectively communicate, adults with acquired brain injury (ABI) also experience high incidences of depression, social isolation, and decreased quality of life. Expressive writing programs have been shown to be effective in alleviating these concomitant impairments in other populations including incarcerated…

  16. High-power 83 W holmium-doped silica fiber laser operating with high beam quality.

    PubMed

    Jackson, Stuart D; Sabella, Alex; Hemming, Alex; Bennetts, Shayne; Lancaster, David G

    2007-02-01

    A high-power 83 W cladding-pumped Tm3+-Ho3+-doped silica fiber laser is reported. Using bidirectional 793 nm diode pumping, a maximum slope efficiency of 42% was produced after a threshold launched pump power of 12 W was exceeded. The laser operated at wavelengths near 2105 nm with moderate beam quality, i.e., M2 approximately 1.5. Further power scaling of the fiber laser was limited by thermal failure of the fiber ends.

  17. High-power 83 W holmium-doped silica fiber laser operating with high beam quality

    NASA Astrophysics Data System (ADS)

    Jackson, Stuart D.; Sabella, Alex; Hemming, Alex; Bennetts, Shayne; Lancaster, David G.

    2007-02-01

    A high-power 83W cladding-pumped Tm3+-Ho3+-doped silica fiber laser is reported. Using bidirectional 793nm diode pumping, a maximum slope efficiency of 42% was produced after a threshold launched pump power of 12W was exceeded. The laser operated at wavelengths near 2105nm with moderate beam quality, i.e., M2˜1.5. Further power scaling of the fiber laser was limited by thermal failure of the fiber ends.

  18. Characterization of non equilibrium effects on high quality critical flows

    SciTech Connect

    Camelo, E.; Lemonnier, H.; Ochterbeck, J.

    1995-09-01

    The appropriate design of various pieces of safety equipment such as relief systems, relies on the accurate description of critical flow phenomena. Most of the systems of industrial interest are willing to be described by one-dimensional area-averaged models and a large fraction of them involves multi-component high gas quality flows. Within these circumstances, the flow is very likely to be of an annular dispersed nature and its description by two-fluid models requires various closure relations. Among the most sensitive closures, there is the interfacial area and the liquid entrained fraction. The critical flowrate depends tremendously on the accurate description of the non equilibrium which results from the correctness of the closure equations. In this study, two-component flows are emphasized and non equilibrium results mainly form the differences in the phase velocities. It is therefore of the utmost importance to have reliable data to characterize non equilibrium phenomena and to assess the validity of the closure models. A comprehensive description of air-water nozzle flows, with emphasis on the effect of the nozzle geometry, has been undertaken and some of the results are presented here which helps understanding the overall flow dynamics. Besides the critical flowrate, the presented material includes pressure profiles, droplet size and velocity, liquid film flowrate and liquid film thickness.

  19. High gain pre-amplifier laser beam quality evaluating system

    NASA Astrophysics Data System (ADS)

    Liu, Yang; Yu, Jin; Zhao, Tianzhuo; Zhang, Xue; Fan, Zhongwei

    2011-06-01

    Designed a system for the high gain laser pre-amplifier to evaluate the image quality. The system uses 4f imaging principle and Kepler type telescope was choiced, it has two advantages: avert optical distortion and eliminate aberration in the measurement system. Combined with the location of the lens inside of pre-amplifier such as the spatial filter , the near field imaging structure was designed. The structure can be reduced to 11.9 times the beam image, and clearly passed the image to the CCD target surface. The location of first positive lens focus is the location of far field image. In this article, one laser pre-amplifier was measured. The average measured near field modulation M=1.34, the average measured far field diffraction limit is 2.94. Experiments show that the stability of measuring system is less than+/-5%, it can meet the measurement requirements of ICF laser pre-amplifier parameters. Use this system we can discover the problem during the design and installation. There is great meaning for develop of laser pre-amplifier in ICF for further.

  20. High quality factor platinum silicide microwave kinetic inductance detectors

    NASA Astrophysics Data System (ADS)

    Szypryt, P.; Mazin, B. A.; Ulbricht, G.; Bumble, B.; Meeker, S. R.; Bockstiegel, C.; Walter, A. B.

    2016-10-01

    We report on the development of microwave kinetic inductance detectors (MKIDs) using platinum silicide as the sensor material. MKIDs are an emerging superconducting detector technology, capable of measuring the arrival times of single photons to better than two microseconds and their energies to around ten percent. Previously, MKIDs have been fabricated using either sub-stoichiometric titanium nitride or aluminum, but TiN suffers from the spatial inhomogeneities in the superconducting critical temperature and Al has a low kinetic inductance fraction, causing low detector sensitivity. To address these issues, we have instead fabricated the PtSi microresonators with the superconducting critical temperatures of 944 ± 12 mK and high internal quality factors ( Q i ≳ 10 6 ). These devices show typical quasiparticle lifetimes of τ q p ≈ 30 - 40 μ s and spectral resolution, R = λ / Δ λ , of 8 at 406.6 nm. We compare PtSi MKIDs to those fabricated with TiN and detail the substantial advantages that PtSi MKIDs have to offer.

  1. Tunable high quality factor in two multimode plasmonic stubs waveguide

    PubMed Central

    Chen, Zhiquan; Li, Hongjian; Zhan, Shiping; Li, Boxun; He, Zhihui; Xu, Hui; Zheng, Mingfei

    2016-01-01

    We numerically investigate the optical characteristics of a metal-dielectric-metal (MDM) waveguide side-coupled with two identical multimode stub resonators. Double plasmon-induced transparency (PIT) peaks with narrow full width at half maximum (FWHM) and high quality factor (Q-factor) can be observed in this structure. The Q-factors of PIT peaks in two stub resonators system are larger than those in single stub resonator system. A multimode coupled-radiation oscillator theory (MC-ROT), which is derived from ROT, is proposed to analyze the spectral response in the multimode system for the first time. The analytical results are confirmed by the finite-difference time-domain (FDTD) simulation results. We can also find that the Q-factors of the two PIT peaks have an opposite evolution tendency with the change of the stubs parameters and the maximum can reach to 427. These results may provide some applications for ultrasensitive sensors, switches and efficient filters. PMID:27075935

  2. Defining High Quality ECED Provision. A Note and an Exercise.

    ERIC Educational Resources Information Center

    Williams, Sian

    This paper examines quality in providing early childhood education and development (ECED) services and presents an exercise to guide critical reflection on quality in ECED provision. It maintains that there has been a shift away from the study of children as solitary learners to the study of children learning in a social context. This research…

  3. Quality Assurance Roadmap for High Performance Residential Buildings

    SciTech Connect

    2008-10-05

    This report outlines the approach to quality assurance in the construction process for new residential construction, including seven process steps from the assessment of current construction practice, through design and documentation changes, to training and quality control for on-site personnel.

  4. Impact of highly active antiretroviral therapy on oral manifestations of patients with human immunodeficiency virus/acquired immuno deficiency syndrome in South India

    PubMed Central

    Rao, K. V. S. Eswara; Chitturi, Ravi Teja; Kattappagari, Kiran Kumar; Kantheti, Lalith Prakash Chandra; Poosarla, Chandrasekhar; Baddam, Venkat Ramana Reddy

    2015-01-01

    Background: Human immunodeficiency virus (HIV) infection remains a global health problem, although the development of highly active antiretroviral therapy (HAART) has significantly modified the course of HIV disease into a manageable disease with improved quality-of-life mainly in the developed countries. Very few studies are available regarding effect of HAART on oral lesions in developing countries like India. Aims and Objectives: The aim was to document and compare oral lesions in HIV-seropositive patients before and after HAART. Materials and Methods: Oral manifestations were recorded in 320 HIV seropositive patients attending to the Voluntary Counseling and Confidential Testing Centre at the Government General Hospital, Guntur, before and after treating with HAART and the results were statistically analyzed using Student's t-test and Chi-square test. Results: Oral Candidiasis was significantly reduced in patients under HAART after 3 months. Furthermore, there was decreased incidence of periodontal diseases, but increased hyperpigmentation in patients undergoing HAART. Conclusion: The oral manifestations of HIV infection have changed due to the advent of HAART. Many opportunistic infections have resolved as a result of an improved immune system. Though the risk of hyperpigmentation in those with HAART has increased the prevalence of oral candidiasis and periodontal diseases were less in patients who had access to HAART. PMID:26392652

  5. Acquired Factor V Inhibitor

    PubMed Central

    Hirai, Daisuke; Yamashita, Yugo; Masunaga, Nobutoyo; Katsura, Toshiaki; Akao, Masaharu; Okuno, Yoshiaki; Koyama, Hiroshi

    2016-01-01

    Inhibitors directed against factor V rarely occur, and the clinical symptoms vary. We herein report the case of a patient who presented with a decreased factor V activity that had decreased to <3 %. We administered vitamin K and 6 units of fresh frozen plasma, but she thereafter developed an intracerebral hemorrhage. It is unclear whether surgery >10 years earlier might have caused the development of a factor V inhibitor. The treatment of acquired factor V inhibitors is mainly the transfusion of platelet concentrates and corticosteroids. Both early detection and the early initiation of the treatment of factor V inhibitor are thus considered to be important. PMID:27746446

  6. Use of high-resolution imagery acquired from an unmanned aircraft system for fluvial mapping and estimating water-surface velocity in rivers

    NASA Astrophysics Data System (ADS)

    Kinzel, P. J.; Bauer, M.; Feller, M.; Holmquist-Johnson, C.; Preston, T.

    2013-12-01

    The use of unmanned aircraft systems (UAS) for environmental monitoring in the United States is anticipated to increase in the coming years as the Federal Aviation Administration (FAA) further develops guidelines to permit their integration into the National Airspace System. The U.S. Geological Survey's (USGS) National Unmanned Aircraft Systems Project Office routinely obtains Certificates of Authorization from the FAA for utilizing UAS technology for a variety of natural resource applications for the U.S. Department of the Interior (DOI). We evaluated the use of a small UAS along two reaches of the Platte River near Overton Nebraska, USA, to determine the accuracy of the system for mapping the extent and elevation of emergent sandbars and to test the ability of a hovering UAS to identify and track tracers to estimate water-surface velocity. The UAS used in our study is the Honeywell Tarantula Hawk RQ16 (T-Hawk), developed for the U.S. Army as a reconnaissance and surveillance platform. The T-Hawk has been recently modified by USGS, and certified for airworthiness by the DOI - Office of Aviation Services, to accommodate a higher-resolution imaging payload than was originally deployed with the system. The T-Hawk is currently outfitted with a Canon PowerShot SX230 HS with a 12.1 megapixel resolution and intervalometer to record images at a user defined time step. To increase the accuracy of photogrammetric products, orthoimagery and DEMs using structure-from-motion (SFM) software, we utilized ground control points in the study reaches and acquired imagery using flight lines at various altitudes (200-400 feet above ground level) and oriented both parallel and perpendicular to the river. Our results show that the mean error in the elevations derived from SFM in the upstream reach was 17 centimeters and horizontal accuracy was 6 centimeters when compared to 4 randomly distributed targets surveyed on emergent sandbars. In addition to the targets, multiple transects were

  7. Reducing hospital acquired pressure ulcers in intensive care

    PubMed Central

    Cullen Gill, Emma

    2015-01-01

    Pressure ulcers are a definite problem in our health care system and are growing in numbers. Unfortunately, it is usually the most weak and vulnerable of our culture that faces these complications, causing the patient and their families discomfort, anguish, and economic hardship due to their expensive treatment. Data collected by the tissue viability department showed high incidence of hospital acquire pressure ulcers in the intensive care unit in March 2013. An action plan was initiated and implemented by the tissue viability team, senior nursing management, pressure ulcer prevention (PUP) team and respiratory therapists (RT's) within the ICU. Our objective was to reduce hospital acquired pressure ulcers in the intensive care unit using the plan, do, check, act quality improvement process. PMID:26734370

  8. [Acquired coagulant factor inhibitors].

    PubMed

    Nogami, Keiji

    2015-02-01

    Acquired coagulation factor inhibitors are an autoimmune disease causing bleeding symptoms due to decreases in the corresponding factor (s) which result from the appearance of autoantibodies against coagulation factors (inhibitor). This disease is quite different from congenital coagulation factor deficiencies based on genetic abnormalities. In recent years, cases with this disease have been increasing, and most have anti-factor VIII autoantibodies. The breakdown of the immune control mechanism is speculated to cause this disease since it is common in the elderly, but the pathology and pathogenesis are presently unclear. We herein describe the pathology and pathogenesis of factor VIII and factor V inhibitors. Characterization of these inhibitors leads to further analysis of the coagulation process and the activation mechanisms of clotting factors. In the future, with the development of new clotting examination method (s), we anticipate that further novel findings will be obtained in this field through inhibitor analysis. In addition, detailed elucidation of the coagulation inhibitory mechanism possibly leading to hemostatic treatment strategies for acquired coagulation factor disorders will be developed.

  9. High power far-infrared optical parametric oscillator with high beam quality

    NASA Astrophysics Data System (ADS)

    Qian, Chuan-Peng; Shen, Ying-Jie; Dai, Tong-Yu; Duan, Xiao-Ming; Yao, Bao-Quan

    2016-11-01

    A high power ZnGeP2 (ZGP) optical parametric oscillator (OPO) with good beam quality pumped by a Q-switched Ho:YAG laser was demonstrated. The maximum output power of the ZGP OPO with a four-mirror ring cavity was about 5.04 W around 8.1 μm with 83.9 W Ho incident pump power, corresponding to a slope efficiency of 9.2 %. The ZGP OPO produced 36.0 ns far-IR pulse laser in the 8.0-8.3 μm spectral regions. The beam quality was measured to be M2 1.6 at the highest output power.

  10. Quality improvement in healthcare in New Zealand. Part 1: what would a high-quality healthcare system look like?

    PubMed

    Seddon, Mary

    2006-07-07

    This Special Series attempts to define what a high-quality healthcare system would look like for New Zealand. The Series focuses on the dimensions of a quality service - safety, access, equity, effectiveness, efficiency, and patient centeredness - not only elucidating in plain language what these dimensions are, but how they might be measured and improved. The central premise is that clinicians need to become involved in measuring and improving the quality of healthcare provided. To assist clinicians, the Series will cover ways to measure the effectiveness of care they provide with articles on clinical audit and clinical indicators, and also to examine the pros and cons of the measures of efficiency used by the funders - organisational performance indicators, and benchmarking. The Series will wrap up with a vision of how we might continue to improve quality through embedding clinical governance into District Health Boards, so that their performance is measured in both quality and fiscal terms.

  11. Three-dimensional rendering of computer-generated holograms acquired from point-clouds on light field displays

    NASA Astrophysics Data System (ADS)

    Symeonidou, Athanasia; Blinder, David; Ceulemans, Beerend; Munteanu, Adrian; Schelkens, Peter

    2016-09-01

    Holograms, either optically acquired or simulated numerically from 3D datasets, such as point clouds, have special rendering requirements for display. Evaluating the quality of hologram generation techniques is not straightforward, since high-quality holographic display technologies are still immature, In this paper we present a framework for three-dimensional rendering of colour computer-generated holograms (CGHs) acquired from point-clouds, on high-end light field displays. This allows for the rendering of holographic content with horizontal parallax and wide viewing angle. We deploy prior work, namely a fast CGH method that inherently handles occlusion problems to acquire high quality colour holograms from point clouds. Our experiments showed that rendering holograms with the proposed framework provides 3D effect with depth disparity and horizontal-only with wide viewing angle. Therefore, it allows for the evaluation of CGH techniques regarding functional properties such as depth cues and efficient occlusion handling.

  12. Consumers' expected quality and intention to purchase high quality pork meat.

    PubMed

    Papanagiotou, P; Tzimitra-Kalogianni, I; Melfou, K

    2013-03-01

    Expected quality is believed to be one of the most important factors that influence consumers' intention to purchase food. The present study seeks to explore the concept of pork meat expected quality and compare it with self-stated consumer intention to purchase pork meat. The aim is attempted by means of a field research conducted in Greece, following a conjoint analytic procedure. Results show that quality expectations comply with intention to buy pork, in many aspects. However, several differences have been identified. More specifically, country of origin and marbling appear to be more important for respondents' purchase decisions than they are for their quality evaluations, while the opposite appears to be true for price. Finally, socio-demographic factors such as gender, level of education, place of purchase and consumption habits seem to influence perceptions.

  13. Best current practice for obtaining high quality EEG data during simultaneous FMRI.

    PubMed

    Mullinger, Karen J; Castellone, Pierluigi; Bowtell, Richard

    2013-06-03

    Simultaneous EEG-fMRI allows the excellent temporal resolution of EEG to be combined with the high spatial accuracy of fMRI. The data from these two modalities can be combined in a number of ways, but all rely on the acquisition of high quality EEG and fMRI data. EEG data acquired during simultaneous fMRI are affected by several artifacts, including the gradient artefact (due to the changing magnetic field gradients required for fMRI), the pulse artefact (linked to the cardiac cycle) and movement artifacts (resulting from movements in the strong magnetic field of the scanner, and muscle activity). Post-processing methods for successfully correcting the gradient and pulse artifacts require a number of criteria to be satisfied during data acquisition. Minimizing head motion during EEG-fMRI is also imperative for limiting the generation of artifacts. Interactions between the radio frequency (RF) pulses required for MRI and the EEG hardware may occur and can cause heating. This is only a significant risk if safety guidelines are not satisfied. Hardware design and set-up, as well as careful selection of which MR sequences are run with the EEG hardware present must therefore be considered. The above issues highlight the importance of the choice of the experimental protocol employed when performing a simultaneous EEG-fMRI experiment. Based on previous research we describe an optimal experimental set-up. This provides high quality EEG data during simultaneous fMRI when using commercial EEG and fMRI systems, with safety risks to the subject minimized. We demonstrate this set-up in an EEG-fMRI experiment using a simple visual stimulus. However, much more complex stimuli can be used. Here we show the EEG-fMRI set-up using a Brain Products GmbH (Gilching, Germany) MRplus, 32 channel EEG system in conjunction with a Philips Achieva (Best, Netherlands) 3T MR scanner, although many of the techniques are transferable to other systems.

  14. Avian influenza: potential impact on sub-Saharan military populations with high rates of human immunodeficiency virus/acquired immunodeficiency syndrome.

    PubMed

    Feldman, Robert L; Nickell, Kent

    2007-07-01

    Several sub-Saharan militaries have large percentages of troops with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome. With the arrival of avian influenza in Africa, the potential exists that some of those soldiers might also become infected with H5N1, the virus responsible for the disease. Two possible scenarios have been postulated regarding how such a coinfection of HIV and H5N1 might present. (1) Soldiers already weakened by HIV/acquired immunodeficiency syndrome rapidly succumb to H5N1. The cause of death is a "cytokine storm," essentially a runaway inflammatory response. (2) The weakened immune system prevents the cytokine storm from occurring; however, H5N1 is still present, replicating, and being shed, leading to the infection of others. A cytokine storm is particularly dangerous for individuals of military age, as evidenced by the large number of soldiers who died during the 1918 influenza epidemic. If large numbers of sub-Saharan soldiers suffer a similar fate from avian influenza, then military and political instability could develop.

  15. Acquired epidermodysplasia verruciformis.

    PubMed

    Rogers, Heather D; Macgregor, Jennifer L; Nord, Kristin M; Tyring, Stephen; Rady, Peter; Engler, Danielle E; Grossman, Marc E

    2009-02-01

    Epidermodysplasia verruciformis (EV) is a rare autosomal recessive genodermatosis with an increased susceptibility to specific human papillomavirus (HPV) genotypes. Classically, this viral infection leads to the development of tinea versicolor-like macules on the trunk, neck, arms, and face during childhood, and over time, these lesions can progress to squamous cell carcinoma. More recently, an EV-like syndrome has been described in patients with impaired cell-mediated immunity. We describe two cases of EV-like syndrome in HIV-positive patients, review all previously reported cases of EV in patients with impaired cell-mediated immunity, introduce the term "acquired epidermodysplasia verruciformis" to describe EV developing in the immunocompromised host and examine the limited treatment options for these patients.

  16. AIDS: acquired immunodeficiency syndrome.

    PubMed Central

    Gilmore, N. J.; Beaulieu, R.; Steben, M.; Laverdière, M.

    1983-01-01

    Acquired immunodeficiency syndrome, or AIDS, is a new illness that occurs in previously healthy individuals. It is characterized by immunodeficiency, opportunistic infections and unusual malignant diseases. Life-threatening single or multiple infections with viruses, mycobacteria, fungi or protozoa are common. A rare neoplasm, Kaposi's sarcoma, has developed in approximately one third of patients with AIDS. More than 800 cases of AIDS have been reported in North America, over 24 of them in Canada. The majority of patients are male homosexuals, although AIDS has also developed in abusers of intravenously administered drugs, Haitian immigrants, individuals with hemophilia, recipients of blood transfusions, prostitutes, and infants, spouses and partners of patients with AIDS. The cause of AIDS is unknown, but the features are consistent with an infectious process. Early diagnosis can be difficult owing to the nonspecific symptoms and signs of the infections and malignant diseases. Therefore, vigilance by physicians is of utmost importance. PMID:6342737

  17. AIDS: acquired immunodeficiency syndrome *

    PubMed Central

    Gilmore, N.J.; Beaulieu, R.; Steben, M.; Laverdière, M.

    1992-01-01

    Acquired immunodeficiency syndrome, or AIDS, is a new illness that occurs in previously healthy individuals. It is characterized by immunodeficiency, opportunistic infections and unusual malignant diseases. Life-threatening single or multiple infections with viruses, mycobacteria, fungi or protozoa are common. A rare neoplasm, Kaposi's sarcoma, has developed in approximately one third of patients with AIDS. More than 800 cases of AIDS have been reported in North America, over 24 of them in Canada. The majority of patients are male homosexuals, although AIDS has also developed in abusers of intravenously administered drugs, Haitian immigrants, individuals with hemophilia, recipients of blood transfusions, prostitutes, and infants, spouses and partners of patients with AIDS. The cause of AIDS is unknown, but the features are consistent with an infectious process. Early diagnosis can be difficult owing to the nonspecific symptoms and signs of the infections and malignant diseases. Therefore, vigilance by physicians is of the utmost importance. PMID:1544049

  18. Sub-micron resolution high-speed spectral domain optical coherence tomography in quality inspection for printed electronics

    NASA Astrophysics Data System (ADS)

    Czajkowski, J.; Lauri, J.; Sliz, R.; Fält, P.; Fabritius, T.; Myllylä, R.; Cense, B.

    2012-04-01

    We present the use of sub-micron resolution optical coherence tomography (OCT) in quality inspection for printed electronics. The device used in the study is based on a supercontinuum light source, Michelson interferometer and high-speed spectrometer. The spectrometer in the presented spectral-domain optical coherence tomography setup (SD-OCT) is centered at 600 nm and covers a 400 nm wide spectral region ranging from 400 nm to 800 nm. Spectra were acquired at a continuous rate of 140,000 per second. The full width at half maximum of the point spread function obtained from a Parylene C sample was 0:98 m. In addition to Parylene C layers, the applicability of sub-micron SD-OCT in printed electronics was studied using PET and epoxy covered solar cell, a printed RFID antenna and a screen-printed battery electrode. A commercial SD-OCT system was used for reference measurements.

  19. High throughput electrospinning of high-quality nanofibers via an aluminum disk spinneret

    NASA Astrophysics Data System (ADS)

    Zheng, Guokuo

    In this work, a simple and efficient needleless high throughput electrospinning process using an aluminum disk spinneret with 24 holes is described. Electrospun mats produced by this setup consisted of fine fibers (nano-sized) of the highest quality while the productivity (yield) was many times that obtained from conventional single-needle electrospinning. The goal was to produce scaled-up amounts of the same or better quality nanofibers under variable concentration, voltage, and the working distance than those produced with the single needle lab setting. The fiber mats produced were either polymer or ceramic (such as molybdenum trioxide nanofibers). Through experimentation the optimum process conditions were defined to be: 24 kilovolt, a distance to collector of 15cm. More diluted solutions resulted in smaller diameter fibers. Comparing the morphologies of the nanofibers of MoO3 produced by both the traditional and the high throughput set up it was found that they were very similar. Moreover, the nanofibers production rate is nearly 10 times than that of traditional needle electrospinning. Thus, the high throughput process has the potential to become an industrial nanomanufacturing process and the materials processed by it may be used as filtration devices, in tissue engineering, and as sensors.

  20. Creating High Quality DEMs of Large Scale Fluvial Environments Using Structure-from-Motion

    NASA Astrophysics Data System (ADS)

    Javernick, L. A.; Brasington, J.; Caruso, B. S.; Hicks, M.; Davies, T. R.

    2012-12-01

    During the past decade, advances in survey and sensor technology have generated new opportunities to investigate the structure and dynamics of fluvial systems. Key geomatic technologies include the Global Positioning System (GPS), digital photogrammetry, LiDAR, and terrestrial laser scanning (TLS). The application of such has resulted in a profound increase in the dimensionality of topographic surveys - from cross-sections to distributed 3d point clouds and digital elevation models (DEMs). Each of these technologies have been used successfully to derive high quality DEMs of fluvial environments; however, they often require specialized and expensive equipment, such as a TLS or large format camera, bespoke platforms such as survey aircraft, and consequently make data acquisition prohibitively expensive or highly labour intensive, thus restricting the extent and frequency of surveys. Recently, advances in computer vision and image analysis have led to development of a novel photogrammetric approach that is fully automated and suitable for use with simple compact (non-metric) cameras. In this paper, we evaluate a new photogrammetric method, Structure-from-Motion (SfM), and demonstrate how this can be used to generate DEMs of comparable quality to airborne LiDAR, using consumer grade cameras at low costs. Using the SfM software PhotoScan (version 0.8.5), high quality DEMs were produced for a 1.6 km reach and a 3.3 km reach of the braided Ahuriri River, New Zealand. Photographs used for DEM creation were acquired from a helicopter flying at 600 m and 800 m above ground level using a consumer grade 10.1mega-pixel, non-metric digital camera, resulting in object space resolution imagery of 0.12 m and 0.16 m respectively. Point clouds for the two study reaches were generated using 147 and 224 photographs respectively, and were extracted automatically in an arbitrary coordinate system; RTK-GPS located ground control points (GCPs) were used to define a 3d non

  1. Building High-Performing and Improving Education Systems: Quality Assurance and Accountability. Review

    ERIC Educational Resources Information Center

    Slater, Liz

    2013-01-01

    Monitoring, evaluation, and quality assurance in their various forms are seen as being one of the foundation stones of high-quality education systems. De Grauwe, writing about "school supervision" in four African countries in 2001, linked the decline in the quality of basic education to the cut in resources for supervision and support.…

  2. Effect of high molecular weight glutenin subunit allelic composition on wheat flour tortilla quality

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Wheat cultivars possessing quality attributes needed to produce optimum quality tortillas have not been identified. This study investigated the effect of variations in high molecular weight glutenin subunits encoded at the Glu-1 loci (Glu-A1, Glu-B1, Glu-D1) on dough properties and tortilla quality....

  3. Does High School Facility Quality Affect Student Achievement? A Two-Level Hierarchical Linear Model

    ERIC Educational Resources Information Center

    Bowers, Alex J.; Urick, Angela

    2011-01-01

    The purpose of this study is to isolate the independent effects of high school facility quality on student achievement using a large, nationally representative U.S. database of student achievement and school facility quality. Prior research on linking school facility quality to student achievement has been mixed. Studies that relate overall…

  4. High Yield Chemical Vapor Deposition Growth of High Quality Large-Area AB Stacked Bilayer Graphene

    PubMed Central

    Liu, Lixin; Zhou, Hailong; Cheng, Rui; Yu, Woo Jong; Liu, Yuan; Chen, Yu; Shaw, Jonathan; Zhong, Xing; Huang, Yu; Duan, Xiangfeng

    2012-01-01

    Bernal stacked (AB stacked) bilayer graphene is of significant interest for functional electronic and photonic devices due to the feasibility to continuously tune its band gap with a vertical electrical field. Mechanical exfoliation can be used to produce AB stacked bilayer graphene flakes but typically with the sizes limited to a few micrometers. Chemical vapor deposition (CVD) has been recently explored for the synthesis of bilayer graphene but usually with limited coverage and a mixture of AB and randomly stacked structures. Herein we report a rational approach to produce large-area high quality AB stacked bilayer graphene. We show that the self-limiting effect of graphene growth on Cu foil can be broken by using a high H2/CH4 ratio in a low pressure CVD process to enable the continued growth of bilayer graphene. A high temperature and low pressure nucleation step is found to be critical for the formation of bilayer graphene nuclei with high AB stacking ratio. A rational design of a two-step CVD process is developed for the growth of bilayer graphene with high AB stacking ratio (up to 90 %) and high coverage (up to 99 %). The electrical transport studies demonstrated that devices made of the as-grown bilayer graphene exhibit typical characteristics of AB stacked bilayer graphene with the highest carrier mobility exceeding 4,000 cm2/V·s at room temperature, comparable to that of the exfoliated bilayer graphene. PMID:22906199

  5. Quality Alternative Certification Programs in Special Education Ensure High Retention

    ERIC Educational Resources Information Center

    Karge, Belinda D.; McCabe, Marjorie

    2014-01-01

    Market driven alternative routes to teaching have evolved into a quality program option and not just an answer to the teacher shortage. Alternative certification is a viable means of recruiting, training, and certifying those who have a bachelor's degree and a strong desire to enter the field of teaching. California has been a leader in the…

  6. Innovation in Business Education: Developing a High Quality Online MBA

    ERIC Educational Resources Information Center

    Roe, C. William; Toma, Alfred G.; Yallapragada, RamMohan R.

    2015-01-01

    Online degree programs were probably pioneered by for-profit universities such as University of Phoenix. Many online degree programs were initially considered low quality academic programs compared to traditional programs. Therefore, many public and private universities were slow to adopt the online programs. However, gradually more and more…

  7. High-Impact Afterschool for All: A Statewide Quality Framework

    ERIC Educational Resources Information Center

    Siaca, Jennifer L.

    2010-01-01

    The need for afterschool programs is clear: Research and practice demonstrate that quality afterschool programs keep youth safe; support working families; and provide critical learning, personal development, arts, and recreational opportunities. New York State alone uses nearly $300 million in local, state, and federal funds for afterschool…

  8. Are We Doing Enough to Stem the Tide of Acquired MDR-TB in Countries with High TB Burden? Results of a Mixed Method Study in Chongqing, China

    PubMed Central

    Li, Ying; Ehiri, John; Oren, Eyal; Hu, Daiyu; Luo, Xingneng; Liu, Ying; Li, Daikun; Wang, Qingya

    2014-01-01

    Multi-drug resistant tuberculosis (MDR-TB) represents a threat to health and development in countries with high TB burden. China’s MDR-TB prevalence rate of 6.8% is the highest in the world. Interventions to remove barriers against effective TB control, and prevention of MDR-TB are urgently needed in the country. This paper reports a cross-sectional questionnaire survey of 513 pulmonary TB (PTB) patients, and qualitative interviews of 10 healthcare workers (HCWs), and 15 PTB patients. The objective was to assess barriers against effective control of PTB and prevention of MDR-TB by elucidating the perspectives of patients and healthcare providers. Results showed that more than half of the patients experienced patient delay of over 12.5 days. A similar proportion also experienced detection delay of over 30 days, and delay in initiating treatment of over 31 days. Consulting a non-TB health facility ≥3 times before seeking care at TB dispensary was a risk factor for both detection delay [AOR (95% CI): 1.89(1.07, 3.34) and delay in initiating treatment[AOR (95% CI): 1.88 (1.06, 3.36). Results revealed poor implementation of Directly Observed Therapy (DOT), whereby treatment of 34.3% patients was never monitored by HCWs. Only 31.8% patients had ever accessed TB health education before their TB diagnosis. Qualitative data consistently disclosed long patient delay, and indicated that patient’s poor TB knowledge and socioeconomic barriers were primary reasons for patient delay. Seeking care and being treated at a non-TB hospital was an important reason for detection delay. Patient’s long work hours and low income increased risk for treatment non-adherence. Evidence-based measures to improve TB health seeking behavior, reduce patient and detection delays, improve the quality of DOT, address financial and system barriers, and increase access to TB health promotion are urgently needed to address the burgeoning prevalence of MDR-TB in China. PMID:24505476

  9. Are we doing enough to stem the tide of acquired MDR-TB in countries with high TB burden? Results of a mixed method study in Chongqing, China.

    PubMed

    Li, Ying; Ehiri, John; Oren, Eyal; Hu, Daiyu; Luo, Xingneng; Liu, Ying; Li, Daikun; Wang, Qingya

    2014-01-01

    Multi-drug resistant tuberculosis (MDR-TB) represents a threat to health and development in countries with high TB burden. China's MDR-TB prevalence rate of 6.8% is the highest in the world. Interventions to remove barriers against effective TB control, and prevention of MDR-TB are urgently needed in the country. This paper reports a cross-sectional questionnaire survey of 513 pulmonary TB (PTB) patients, and qualitative interviews of 10 healthcare workers (HCWs), and 15 PTB patients. The objective was to assess barriers against effective control of PTB and prevention of MDR-TB by elucidating the perspectives of patients and healthcare providers. Results showed that more than half of the patients experienced patient delay of over 12.5 days. A similar proportion also experienced detection delay of over 30 days, and delay in initiating treatment of over 31 days. Consulting a non-TB health facility ≥3 times before seeking care at TB dispensary was a risk factor for both detection delay [AOR (95% CI): 1.89(1.07, 3.34) and delay in initiating treatment[AOR (95% CI): 1.88 (1.06, 3.36). Results revealed poor implementation of Directly Observed Therapy (DOT), whereby treatment of 34.3% patients was never monitored by HCWs. Only 31.8% patients had ever accessed TB health education before their TB diagnosis. Qualitative data consistently disclosed long patient delay, and indicated that patient's poor TB knowledge and socioeconomic barriers were primary reasons for patient delay. Seeking care and being treated at a non-TB hospital was an important reason for detection delay. Patient's long work hours and low income increased risk for treatment non-adherence. Evidence-based measures to improve TB health seeking behavior, reduce patient and detection delays, improve the quality of DOT, address financial and system barriers, and increase access to TB health promotion are urgently needed to address the burgeoning prevalence of MDR-TB in China.

  10. Water Quality: A Field-Based Quality Testing Program for Middle Schools and High Schools.

    ERIC Educational Resources Information Center

    Massachusetts State Water Resources Authority, Boston.

    This manual contains background information, lesson ideas, procedures, data collection and reporting forms, suggestions for interpreting results, and extension activities to complement a water quality field testing program. Information on testing water temperature, water pH, dissolved oxygen content, biochemical oxygen demand, nitrates, total…

  11. Manufacturing High-Quality Carbon Nanotubes at Lower Cost

    NASA Technical Reports Server (NTRS)

    Benavides, Jeanette M.; Lidecker, Henning

    2004-01-01

    A modified electric-arc welding process has been developed for manufacturing high-quality batches of carbon nanotubes at relatively low cost. Unlike in some other processes for making carbon nanotubes, metal catalysts are not used and, consequently, it is not necessary to perform extensive cleaning and purification. Also, unlike some other processes, this process is carried out at atmospheric pressure under a hood instead of in a closed, pressurized chamber; as a result, the present process can be implemented more easily. Although the present welding-based process includes an electric arc, it differs from a prior electric-arc nanotube-production process. The welding equipment used in this process includes an AC/DC welding power source with an integral helium-gas delivery system and circulating water for cooling an assembly that holds one of the welding electrodes (in this case, the anode). The cathode is a hollow carbon (optionally, graphite) rod having an outside diameter of 2 in. (approximately equal to 5.1 cm) and an inside diameter of 5/8 in. (approximately equal to 1.6 cm). The cathode is partly immersed in a water bath, such that it protrudes about 2 in. (about 5.1 cm) above the surface of the water. The bottom end of the cathode is held underwater by a clamp, to which is connected the grounding cable of the welding power source. The anode is a carbon rod 1/8 in. (approximately equal to 0.3 cm) in diameter. The assembly that holds the anode includes a thumbknob- driven mechanism for controlling the height of the anode. A small hood is placed over the anode to direct a flow of helium downward from the anode to the cathode during the welding process. A bell-shaped exhaust hood collects the helium and other gases from the process. During the process, as the anode is consumed, the height of the anode is adjusted to maintain an anode-to-cathode gap of 1 mm. The arc-welding process is continued until the upper end of the anode has been lowered to a specified height

  12. Acquired aplastic anemia.

    PubMed

    Keohane, Elaine M

    2004-01-01

    Acquired aplastic anemia (AA) is a disorder characterized by a profound deficit of hematopoietic stem and progenitor cells, bone marrow hypocellularity, and peripheral blood pancytopenia. It primarily affects children, young adults, and those over 60 years of age. The majority of cases are idiopathic; however, idiosyncratic reactions to some drugs, chemicals, and viruses have been implicated in its etiology. An autoimmune T-cell reaction likely causes the stem cell depletion, but the precise mechanism, as well as the eliciting and target antigens, is unknown. Symptoms vary from severe life-threatening cytopenias to moderate or non-severe disease that does not require transfusion support. The peripheral blood typically exhibits pancytopenia, reticulocytopenia, and normocytic or macrocytic erythrocytes. The bone marrow is hypocellular and may exhibit dysplasia of the erythrocyte precursors. First line treatment for severe AA consists of hematopoietic stem cell transplantation in young patients with HLA identical siblings, while immunosuppression therapy is used for older patients and for those of any age who lack a HLA matched donor. Patients with AA have an increased risk of developing paroxysmal nocturnal hemoglobinuria (PNH), myelodysplastic syndrome (MDS), or acute leukemia. Further elucidation of the pathophysiology of this disease will result in a better understanding of the interrelationship among AA, PNH, and MDS, and may lead to novel targeted therapies.

  13. Acquired spatial dyslexia.

    PubMed

    Siéroff, E

    2015-08-10

    Acquired spatial dyslexia is a reading disorder frequently occurring after left or right posterior brain lesions. This article describes several types of spatial dyslexia with an attentional approach. After right posterior lesions, patients show left neglect dyslexia with errors on the left side of text, words, and non-words. The deficit is frequently associated with left unilateral spatial neglect. Severe left neglect dyslexia can be detected with unlimited exposure duration of words or non-words. Minor neglect dyslexia is detected with brief presentation of bilateral words, one in the left and one in the right visual field (phenomenon of contralesional extinction). Neglect dyslexia can be explained as a difficulty in orienting attention to the left side of verbal stimuli. With left posterior lesions, spatial dyslexia is also frequent but multiform. Right neglect dyslexia is frequent, but right unilateral spatial neglect is rare. Attentional dyslexia represents difficulty in selecting a stimulus, letter or word among other similar stimuli; it is a deficit of attentional selection, and the left hemisphere plays a crucial role in selection. Two other types of spatial dyslexia can be found after left posterior lesions: paradoxical ipsilesional extinction and stimulus-centred neglect dyslexia. Disconnections between left or right parietal attentional areas and the left temporal visual word form area could explain these deficits. Overall, a model of attention dissociating modulation, selection control, and selection positioning can help in understanding these reading disorders.

  14. Health-Related Quality of Life in Children with High-Functioning Autism

    ERIC Educational Resources Information Center

    Potvin, Marie-Christine; Snider, Laurie; Prelock, Patricia A.; Wood-Dauphinee, Sharon; Kehayia, Eva

    2015-01-01

    The health-related quality of life of school-aged children with high-functioning autism is poorly understood. The objectives of this study were to compare the health-related quality of life of children with high-functioning autism to that of typically developing peers and to compare child-self and parent-proxy reports of health-related quality of…

  15. High quality Imaging for space VLBI observations with ultra high angular resolution

    NASA Astrophysics Data System (ADS)

    Likhachev, S.

    2001-01-01

    The focus of this presentation will be the problems associated with obtaining high quality images from a high orbiting space VLBI (SVLBI) mission. SVLBI intensifies and magnifies all imaging problems, making these problems clearer to understand, though much harder to solve. It is necessary to notice that as an astronomical instrument SVLBI possesses one explicit advantage: it is an extremely high angular resolution. Currently it could be up to microarcseconds and unlimited potentially in prospect. At the same time we have to "pay" for this advantage by a few disadvantages making high orbiting SVLBI mission hard to implement. These disadvantages are the following: phase instability, poor (u,v)-coverage, low sensitivity. Possible ways of the solution the problems above were considered. These ways could be the following: usage of Multi-Frequency Synthesis (MFS) enable us to improve poor (u,v)-coverage, dynamic range, and phase instability; usage of sensitive radio telescopes or compact arrays as ground support of the SVLBI mission enable us to improve a sensitivity of the SVLBI mission; usage of two or more space-borne radio telescopes enable us to improve poor (u,v)-coverage and sensitivity; developing a modern imaging technology.

  16. Watt-class high-power, high-beam-quality photonic-crystal lasers

    NASA Astrophysics Data System (ADS)

    Hirose, Kazuyoshi; Liang, Yong; Kurosaka, Yoshitaka; Watanabe, Akiyoshi; Sugiyama, Takahiro; Noda, Susumu

    2014-05-01

    The applications of surface-emitting lasers, in particular vertical-cavity surface-emitting lasers (VCSELs), are currently being extended to various low-power fields including communications and interconnections. However, the fundamental difficulties in increasing their output power by more than several milliwatts while maintaining single-mode operation prevent their application in high-power fields such as material processing, laser medicine and nonlinear optics, despite their advantageous properties of circular beams, the absence of catastrophic optical damage, and their suitability for two-dimensional integration. Here, we demonstrate watt-class high-power, single-mode operation by a two-dimensional photonic-crystal surface-emitting laser under room-temperature, continuous-wave conditions. The two-dimensional band-edge resonant effect of a photonic crystal formed by metal-organic chemical vapour deposition enables a 1,000 times broader coherent-oscillation area, which results in a high beam quality of M2 <= 1.1, narrowing the focus spot by two orders of magnitude compared to VCSELs. Our demonstration promises to realize innovative high-power applications for surface-emitting lasers.

  17. High-resolution multigrating spectrometer for high-quality deep-UV light source production

    NASA Astrophysics Data System (ADS)

    Suzuki, Toru; Kubo, Hirokazu; Suganuma, Takashi; Yamashita, Toshio; Wakabayashi, Osamu; Mizoguchi, Hakaru

    2001-09-01

    Deep UV lithography using ArF excimer laser requires very narrower spectral properties. However, spectrometers that have sufficient resolution to evaluate the ArF excimer laser are commercially not available. High-resolution multi-grating spectrometers for measuring spectral bandwidth at full width at half maximum (FWHM) and spectral purity of ArF excimer lasers are introduced. To achieve high resolution, a special grating arrangement called HEXA (Holographic and Echelle Gratings Expander Arrangement) is designed. A holographic grating and an echelle grating are used so that the input light is expanded and diffracted several times. The resolution of the HEXA spectrometer is more than two million. To evaluate the resolution and the stability of the spectrometer, we measured the instrument function by a coherent light source whose wavelength is same as ArF excimer laser. The experimentally obtained resolution of the spectrometer is 0.09pm or 0.05pm that is selectable. The measured dispersion has a good agreement with the theoretical value. To evaluate the spectral properties of excimer lasers, the instrument function must be very stable. This high-resolution spectrometer enables high quality control of line-narrowed ArF excimer laser mass production.

  18. Implementing 15 Essential Elements for High Quality: A State and Local Policy Scan

    ERIC Educational Resources Information Center

    Barnett, W. Steven; Weisenfeld, G. G.; Brown, Kirsty; Squires, Jim; Horowitz, Michelle

    2016-01-01

    This report explores the extent to which states (and several large cities) are positioned to provide high quality preschool education on a large scale. States and cities that are already doing so or that could do so with modest improvements offer opportunities for advocacy to advance access to high quality early education as well as for rigorous…

  19. Roadmap for High School Feedback Reports: Key Focus Areas to Ensure Quality Implementation. Data for Action

    ERIC Educational Resources Information Center

    Data Quality Campaign, 2014

    2014-01-01

    High school feedback reports let school and district leaders know where their students go after graduation and how well they are prepared for college and beyond. This roadmap discusses the seven key focus areas the Data Quality Campaign (DQC) recommends states work on to ensure quality implementation of high school feedback reports.

  20. Child Care and Mothers' Mental Health: Is High-Quality Care Associated with Fewer Depressive Symptoms?

    ERIC Educational Resources Information Center

    Gordon, Rachel A.; Usdansky, Margaret L.; Wang, Xue; Gluzman, Anna

    2011-01-01

    Finding high-quality child care may pose financial and logistical challenges and create ongoing emotional strains for some mothers. We use the Study of Early Child Care and Youth Development to ask (a) are child-care settings that mothers select on the basis of their own perceptions of quality rated more highly by independent observers (and more…

  1. Select Novice Elementary Teachers' Perceived Knowledge and Implementation of High-Quality Reading Instruction

    ERIC Educational Resources Information Center

    Bumstead, Stacey

    2012-01-01

    The purpose of this mixed methods study was to examine select novice teachers' perceived knowledge of high-quality reading instruction, explore the extent that select novice teachers implemented high-quality reading instruction into their own classrooms, and to investigate any factors that explain the similarities and differences between…

  2. Creating High-Quality Preschool: Ideas for Supporting Early Learning Programs. [Videotape].

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC.

    Recognizing that a quality preschool program is key to children's high achievement, this videotape presents a U.S. Department of Education teleconference on creating high quality preschool programs and federal funding available for such programs. Panelists from the Department include the director of the Early Childhood Institute in the Office of…

  3. Acquired reactive perforating collagenosis

    PubMed Central

    Fei, Chengwen; Wang, Yao; Gong, Yu; Xu, Hui; Yu, Qian; Shi, Yuling

    2016-01-01

    Abstract Background: Reactive perforating collagenosis (RPC) is a rare form of transepithelial elimination, in which altered collagen is extruded through the epidermis. There are 2 types of RPC, acquired RPC (ARPC) and inherited RPC, while the latter is extremely rare. Here we report on 1 case of ARPC. Methods: A 73-year-old female was presented with strongly itchy papules over her back and lower limbs for 3 months. She denied the history of oozing or vesiculation. A cutaneous examination showed diffusely distributed multiple well-defined keratotic papules, 4 to 10 mm in diameter, on the bilateral lower limbs and back as well as a few papules on her chest and forearm. Scratching scars were over the resolved lesions while Koebner phenomenon was negative. The patient had a history of type 2 diabetes for 15 years. Laboratory examinations showed elevated blood glucose level. Skin lesion biopsy showed a well-circumscribed area of necrosis filled with a keratotic plug. Parakeratotic cells and lymphocytic infiltration could be seen in the necrosed area. In dermis, sparse fiber bundles were seen perforating the epidermis. These degenerated fiber bundles were notarized as collagen fiber by elastic fiber stain, suggesting a diagnosis of RPC. Results: Then a diagnosis of ARPC was made according to the onset age and the history of diabetes mellitus. She was treated with topical application of corticosteroids twice a day and oral antihistamine once a day along with compound glycyrrhizin tablets 3 times a day. And the blood glucose was controlled in a satisfying range. Two months later, a significant improvement was seen in this patient. Conclusion: Since there is no efficient therapy to RPC, moreover, ARPC is considered to be associated with some systemic diseases, the management of the coexisting disease is quite crucial. The patient in this case received a substantial improvement due to the control of blood glucose and application of compound glycyrrhizin tablets. PMID

  4. Measurement system with high accuracy for laser beam quality.

    PubMed

    Ke, Yi; Zeng, Ciling; Xie, Peiyuan; Jiang, Qingshan; Liang, Ke; Yang, Zhenyu; Zhao, Ming

    2015-05-20

    Presently, most of the laser beam quality measurement system collimates the optical path manually with low efficiency and low repeatability. To solve these problems, this paper proposed a new collimated method to improve the reliability and accuracy of the measurement results. The system accuracy controlled the position of the mirror to change laser beam propagation direction, which can realize the beam perpendicularly incident to the photosurface of camera. The experiment results show that the proposed system has good repeatability and the measuring deviation of M2 factor is less than 0.6%.

  5. Local extinction of dragonfly and damselfly populations in low- and high-quality habitat patches.

    PubMed

    Suhonen, Jukka; Hilli-Lukkarinen, Milla; Korkeamäki, Esa; Kuitunen, Markku; Kullas, Johanna; Penttinen, Jouni; Salmela, Jukka

    2010-08-01

    Understanding the risk of extinction of a single population is an important problem in both theoretical and applied ecology. Local extinction risk depends on several factors, including population size, demographic or environmental stochasticity, natural catastrophe, or the loss of genetic diversity. The probability of local extinction may also be higher in low-quality sink habitats than in high-quality source habitats. We tested this hypothesis by comparing local extinction rates of 15 species of Odonata (dragonflies and damselflies) between 1930-1975 and 1995-2003 in central Finland. Local extinction rates were higher in low-quality than in high-quality habitats. Nevertheless, for the three most common species there were no differences in extinction rates between low- and high-quality habitats. Our results suggest that a good understanding of habitat quality is crucial for the conservation of species in heterogeneous landscapes.

  6. An assessment of the behavioral toxicity of high-energy iron particles compared to other qualities of radiation

    SciTech Connect

    Rabin, B.M.; Hunt, W.A.; Joseph, J.A. )

    1989-07-01

    Conditioned taste aversion was used to evaluate the behavioral toxicity of exposure to high-energy iron particles ({sup 56}Fe, 600 MeV/amu) in comparison to that of gamma photons ({sup 60}Co), high-energy electrons, or fission neutrons. Exposure to high-energy iron particles (5-500 cGy) produced a dose-dependent taste aversion with a maximal effect achieved with a dose of 30 cGy. Gamma photons and electrons were the least effective stimuli for producing a conditioned taste aversion, with a maximal aversion obtained only after exposure to 500 cGy, while the effectiveness of fission neutrons was intermediate to that of photons and iron particles, and a maximal aversion was obtained with a dose of 100 cGy. In the second experiment, rats with lesions of the area postrema were exposed to iron particles (30 cGy), but failed to acquire a taste aversion. The results indicate that (1) high-energy iron particles are more toxic than other qualities of radiation and (2) similar mechanisms mediate the behavioral toxicity of gamma photons and high-energy iron particles.

  7. Assessment of the behavioral toxicity of high-energy iron particles compared to other qualities of radiation

    SciTech Connect

    Rabin, B.M.; Hunt, W.A.; Joseph, J.A.

    1989-01-01

    Conditioned taste aversion was used to evaluate the behavioral toxicity of exposure to high-energy iron particles (56Fe, 600 MeV/amu) in comparison to that of gamma photons (60 Co), high-energy electrons, or fission neutrons. Exposure to high-energy iron particles (5-500 cGy) produced a dose-dependent taste aversion with a maximal effect achieved with a dose of 30 cGy. Gamma photons and electrons were the least-effective stimuli for producing a conditioned taste aversion, with a maximal aversion obtained only after exposure to 500 cGy, while the effectiveness of fission neutrons was intermediate to that of photons and iron particles, and a maximal aversion was obtained with a dose of 100 CGy. In the second experiment, rats with lesions of the area postrema were exposed to iron particles (3- cGY), but failed to acquire a taste aversion. The results indicate that (1) high-energy iron particles are more toxic than other qualities of radiation and (2) similar mechanisms mediate the behavioral toxicity of gamma photons and high-energy iron particles.

  8. Publishing high-quality climate data on the semantic web

    NASA Astrophysics Data System (ADS)

    Woolf, Andrew; Haller, Armin; Lefort, Laurent; Taylor, Kerry

    2013-04-01

    The effort over more than a decade to establish the semantic web [Berners-Lee et. al., 2001] has received a major boost in recent years through the Open Government movement. Governments around the world are seeking technical solutions to enable more open and transparent access to Public Sector Information (PSI) they hold. Existing technical protocols and data standards tend to be domain specific, and so limit the ability to publish and integrate data across domains (health, environment, statistics, education, etc.). The web provides a domain-neutral platform for information publishing, and has proven itself beyond expectations for publishing and linking human-readable electronic documents. Extending the web pattern to data (often called Web 3.0) offers enormous potential. The semantic web applies the basic web principles to data [Berners-Lee, 2006]: using URIs as identifiers (for data objects and real-world 'things', instead of documents) making the URIs actionable by providing useful information via HTTP using a common exchange standard (serialised RDF for data instead of HTML for documents) establishing typed links between information objects to enable linking and integration Leading examples of 'linked data' for publishing PSI may be found in both the UK (http://data.gov.uk/linked-data) and US (http://www.data.gov/page/semantic-web). The Bureau of Meteorology (BoM) is Australia's national meteorological agency, and has a new mandate to establish a national environmental information infrastructure (under the National Plan for Environmental Information, NPEI [BoM, 2012a]). While the initial approach is based on the existing best practice Spatial Data Infrastructure (SDI) architecture, linked-data is being explored as a technological alternative that shows great promise for the future. We report here the first trial of government linked-data in Australia under data.gov.au. In this initial pilot study, we have taken BoM's new high-quality reference surface

  9. Toward of a highly integrated probe for improving wireless network quality

    NASA Astrophysics Data System (ADS)

    Ding, Fei; Song, Aiguo; Wu, Zhenyang; Pan, Zhiwen; You, Xiaohu

    2016-10-01

    Quality of service and customer perception is the focus of the telecommunications industry. This paper proposes a low-cost approach to the acquisition of terminal data, collected from LTE networks with the application of a soft probe, based on the Java language. The soft probe includes support for fast call in the form of a referenced library, and can be integrated into various Android-based applications to automatically monitor any exception event in the network. Soft probe-based acquisition of terminal data has the advantages of low cost and can be applied on large scale. Experiment shows that a soft probe can efficiently obtain terminal network data. With this method, the quality of service of LTE networks can be determined from acquired wireless data. This work contributes to efficient network optimization, and the analysis of abnormal network events.

  10. High performance photodetectors based on high quality InP nanowires

    NASA Astrophysics Data System (ADS)

    Yang, Yan-Kun; Yang, Tie-Feng; Li, Hong-Lai; Qi, Zhao-Yang; Chen, Xin-Liang; Wu, Wen-Qiang; Hu, Xue-Lu; He, Peng-Bin; Jiang, Ying; Hu, Wei; Zhang, Qing-Lin; Zhuang, Xiu-Juan; Zhu, Xiao-Li; Pan, An-Lian

    2016-11-01

    In this paper, small diameter InP nanowires with high crystal quality were synthesized through a chemical vapor deposition method. Benefitting from the high crystallinity and large specific surface area of InP nanowires, the simply constructed photodetector demonstrates a high responsivity of up to 1170 A·W-1 and an external quantum efficiency of 2.8×105% with a fast rise time of 110 ms and a fall time of 130 ms, even at low bias of 0.1 V. The effect of back-gate voltage on photoresponse of the device was systematically investigated, confirming that the photocurrent dominates over thermionic and tunneling currents in the whole operation. A mechanism based on energy band theory at the junction between metal and semiconductor was proposed to explain the back-gate voltage dependent performance of the photodetectors. These convincing results indicate that fine InP nanowires will have a brilliant future in smart optoelectronics. Project supported by the National Natural Science Foundation of China (Grant Nos. 51525202, 61574054, 61505051, and 61474040), the Science and Technology Plan of Hunan Province, China (Grant Nos. 2014FJ2001 and 2014TT1004), and the Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province, China.

  11. High Rate Deposition of High Quality ZnO:Al by Filtered Cathodic Arc

    SciTech Connect

    Mendelsberg, Rueben J.; Lim, S.H.N.; Milliron, D.J.; Anders, Andre

    2010-11-18

    High quality ZnO:Al (AZO) thin films were prepared on glass substrates by direct current filtered cathodic arc deposition. Substrate temperature was varied from room temperature to 425oC, and samples were grown with and without the assistance of low power oxygen plasma (75W). For each growth condition, at least 3 samples were grown to give a statistical look at the effect of the growth environment on the film properties and to explore the reproducibility of the technique. Growth rate was in the 100-400 nm/min range but was apparently random and could not be easily traced to the growth conditions explored. For optimized growth conditions, 300-600 nm AZO films had resistivities of 3-6 x 10-4 ?Omega cm, carrier concentrations in the range of 2-4 x 1020 cm3, Hall mobility as high as 55 cm2/Vs, and optical transmittance greater than 90percent. These films are also highly oriented with the c-axis perpendicular to the substrate and a surface roughness of 2-4 nm.

  12. The high cost of low quality in R D (research and development)

    SciTech Connect

    Wells, C.V.

    1990-10-01

    The principles of quality assurance and quality control yield high payoffs when applied to research activities. Researchers are usually highly motivated individuals who earnestly desire to produce excellent results. The nature of research and the temperament of researchers are such that considerable freedom and latitude are usually required so that the creative processes are not impeded. These are approaches that can be used in applying quality assurance and control that researchers will accept and use when they see the payoff. Some examples are given, with particular emphasis on quality cost systems applied to measurement processes in R D. 14 refs.

  13. Diode Pumped Alkali Vapor Lasers - A New Pathway to High Beam Quality at High Average Power

    SciTech Connect

    Page, R H; Boley, C D; Rubenchik, A M; Beach, R J

    2005-05-06

    Resonance-transition alkali-vapor lasers have only recently been demonstrated [1] but are already attracting considerable attention. Alkali-atom-vapor gain media are among the simplest possible systems known, so there is much laboratory data upon which to base performance predictions. Therefore, accurate modeling is possible, as shown by the zero- free-parameter fits [2] to experimental data on alkali-vapor lasers pumped with Ti:sapphire lasers. The practical advantages of two of the alkali systems--Rb and Cs--are enormous, since they are amenable to diode-pumping [3,4]. Even without circulating the gas mixture, these lasers can have adequate cooling built-in owing to the presence of He in their vapor cells. The high predicted (up to 70%) optical-to-optical efficiency of the alkali laser, the superb (potentially 70% or better) wall-plug efficiency of the diode pumps, and the ability to exhaust heat at high temperature (100 C) combine to give a power-scalable architecture that is lightweight. A recent design exercise [5] at LLNL estimated that the system ''weight-to-power ratio'' figure of merit could be on the order of 7 kg/kW, an unprecedented value for a laser of the 100 kW class. Beam quality is expected to be excellent, owing to the small dn/dT value of the gain medium. There is obviously a long way to go, to get from a small laser pumped with a Ti:sapphire or injection-seeded diode system (of near-perfect beam quality, and narrow linewidth) [1, 4] to a large system pumped with broadband, multimode diode- laser arrays. We have a vision for this technology-development program, and have already built diode-array-pumped Rb lasers at the 1 Watt level. A setup for demonstrating Diode-array-Pumped Alkali vapor Lasers (DPALs) is shown in Figure 1. In general, use of a highly-multimode, broadband pump source renders diode-array-based experiments much more difficult than the previous ones done with Ti:sapphire pumping. High-NA optics, short focal distances, and short

  14. Surface structures of high-quality diamond crystals synthesized by the oxy-acetylene flame method

    NASA Astrophysics Data System (ADS)

    Hirabayashi, Keiji; Amanuma, Shuji; Hirose, Yoichi

    1992-02-01

    The microstructures of the {111} surfaces of high-quality diamond crystals deposited by the oxy-acetylene flame method have been studied using a high-resolution scanning electron microscope to clear the mechanism of the crystal growth. On the {111} surfaces of the high-quality diamond crystals, the two-dimensional nucleation rate is suppressed and the two-dimensional crystal growth rate is promoted. The suppression of the two-dimensional nucleation rate and the promotion of the two-dimensional crystal growth rate reduce the number of faults, dislocations, and defects and result in the formation of high-quality diamond crystals.

  15. What Does Quality Programming Mean for High Achieving Students?

    ERIC Educational Resources Information Center

    Samudzi, Cleo

    2008-01-01

    The Missouri Academy of Science, Mathematics and Computing (Missouri Academy) is a two-year accelerated, early-entrance-to-college, residential school that matches the level, complexity and pace of the curriculum with the readiness and motivation of high achieving high school students. The school is a part of Northwest Missouri State University…

  16. High-Quality Preschool Programs Found to Improve Adult Status.

    ERIC Educational Resources Information Center

    Weikart, David

    1996-01-01

    The longitudinal High Scope/Perry Preschool Study of 123 African Americans in poverty and at high risk of school failure interviewed 95% of participants at age 27. Profiles indicate that participants had fewer criminal arrests, higher earnings and property wealth, and greater commitment to marriage than nonparticipants, suggesting significant…

  17. High quality Gaussian basis sets for fourth-row atoms

    NASA Technical Reports Server (NTRS)

    Partridge, Harry; Faegri, Knut, Jr.

    1992-01-01

    Energy optimized Gaussian basis sets of triple-zeta quality for the atoms Rb-Xe have been derived. Two series of basis sets are developed: (24s 16p 10d) and (26s 16p 10d) sets which were expanded to 13d and 19p functions as the 4d and 5p shells become occupied. For the atoms lighter than Cd, the (24s 16p 10d) sets with triple-zeta valence distributions are higher in energy than the corresponding double-zeta distribution. To ensure a triple-zeta distribution and a global energy minimum, the (26s 16p 10d) sets were derived. Total atomic energies from the largest basis sets are between 198 and 284 (mu)E(sub H) above the numerical Hartree-Fock energies.

  18. A Perfect Electromagnetic Cavity: High Quality Factor in Subwavelength Dimensions

    NASA Astrophysics Data System (ADS)

    Ginis, Vincent; Tassin, Philippe; Soukoulis, Costas M.; Veretennicoff, Irina

    2010-03-01

    Transformation optics has recently provided a new way to look at the interaction between light and matter. It uses the analogy between the macroscopic Maxwell's equations in complex dielectrics and the free-space Maxwell's equations on the background of an arbitrary metric to exploit the full potential of metamaterials, of which the most exciting examples are invisibility cloaks. In this contribution, we want to show how transformation optics can be applied to design a cavity with extraordinary properties. We have demonstrated theoretically the existence of eigenmodes whose wavelength is much larger than the characteristic dimensions of the cavity. Furthermore, our design avoids the bending losses observed in traditional microcavities, so that the quality factor is only limited by intrinsic absorption of the materials. Such a ``perfect cavity'' may be interesting for applications involving optical data storage or quantum optics, where it can be used to control the rate of spontaneous emission through the Purcell effect.

  19. Anomalous Behavior of High Quality Factor Planar Superconducting Resonators

    NASA Astrophysics Data System (ADS)

    Megrant, Anthony; Chen, Zijun; Chiaro, Ben; Dunsworth, Andrew; Quintana, Chris; Campbell, Brooks; Kelly, Julian; Barends, Rami; Chen, Yu; Jeffrey, Evan; Mutus, Josh; Neill, Charles; O'Malley, Peter; Sank, Daniel; Vainsencher, Amit; Wenner, Jim; White, Ted; Bochmann, Jorg; Hoi, Iochun; Palmstrom, Christopher; Martinis, John; Cleland, Andrew

    2014-03-01

    Superconducting coplanar waveguide resonators have proven to be invaluable tools in studying some of the decoherence mechanisms found in superconducting qubits. Surface two-level states tend to dominate decoherence at temperatures below Tc/10 and at very low microwave powers, assuming loss through other channels (e.g. quasiparticles, vortices, and radiation loss) has been mitigated through proper shielding and design. I will present recent measurements of resonators whose behavior diverges significantly from the standard two-level state model at low temperatures and low excitation energies, resulting in startling behavior of the internal quality factor. This research was funded by the Office of the Director of National Intelligence (ODNI), Intelligence Advanced Research Projects Activity (IARPA), through the Army Research Office grant W911NF-09-1-0375.

  20. High cortisol levels are associated with low quality food choice in type 2 diabetes.

    PubMed

    Duong, Michelle; Cohen, Jessica I; Convit, Antonio

    2012-02-01

    Hypothalamic-pituitary-adrenal (HPA) axis control may be impaired in type 2 diabetes (T2DM). Glucocorticoids increase consumption of low quality foods high in calories, sugar, and fat. We explored the relationship between cortisol levels, poor blood glucose control, and food quality choice in T2DM. Twenty-seven healthy controls were age-, gender- and education-matched to 27 T2DM participants. Standard clinical blood tests and cortisol values were measured from fasting blood samples. Participants recorded all consumed food and drink items in a consecutive 3-day food diary. Diaries were analyzed for "high quality" and "low quality" foods using a standardized method with high reliability (0.97 and 0.86, respectively). Controlling for education, body mass index (BMI) and hemoglobin A1C (HbA1C), log-transformed cortisol (LogC) predicted the percent of low quality foods (R (2) = 0.092, β = 0.360, P < 0.05), but not the percent of high quality foods chosen. Controlling for education, BMI, and LogC, HbA1C significantly predicted both the percent of low quality foods (ΔR (2) = 0.079, β = 0.348, P = 0.024) and high quality foods chosen (ΔR (2) = 0.085, β = -0.362, P = 0.022). The relationship between HbA1C and low quality food choice may be mediated by cortisol, controlling for BMI and education (P < 0.01). HbA1C displayed both an indirect (cortisol-mediated) effect (P < 0.05) and direct effect on low quality food choice (P < 0.05). The relationship between HbA1C and low quality food choice may be partially mediated by cortisol. Poor blood glucose control may cause HPA axis disruption, increased consumption of low quality foods.

  1. 16 CFR 801.2 - Acquiring and acquired persons.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Acquiring and acquired persons. 801.2 Section 801.2 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 COVERAGE RULES § 801.2...

  2. 16 CFR 801.2 - Acquiring and acquired persons.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Acquiring and acquired persons. 801.2 Section 801.2 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 COVERAGE RULES § 801.2...

  3. 16 CFR 801.2 - Acquiring and acquired persons.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Acquiring and acquired persons. 801.2 Section 801.2 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 COVERAGE RULES § 801.2...

  4. 16 CFR 801.2 - Acquiring and acquired persons.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Acquiring and acquired persons. 801.2 Section 801.2 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 COVERAGE RULES § 801.2...

  5. 16 CFR 801.2 - Acquiring and acquired persons.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Acquiring and acquired persons. 801.2 Section 801.2 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 COVERAGE RULES § 801.2...

  6. Quality control for bone quality parameters affected by subject motion in high-resolution peripheral quantitative computed tomography.

    PubMed

    Pauchard, Yves; Liphardt, Anna-Maria; Macdonald, Heather M; Hanley, David A; Boyd, Steven K

    2012-06-01

    Subject motion during high-resolution peripheral quantitative computed tomography (HR-pQCT) causes image artifacts that affect morphological analysis of bone quality. The aim of our study was to determine effectiveness of techniques for quality control in the presence of motion in vivo including automated and manual approaches. First, repeatability of manual grading was determined within and between laboratories. Given proper training using a standardized scale and training images (provided by the manufacturer), we found that manual grading is suitable for repeatable image quality grading within and across sites (ICC>0.7). Both a new automated technique providing motion measures based on projection moments, and traditional manual grading (1=best, 5=worst) were subsequently used to assess subject data for motion in N=137 image pairs (scan/re-scan) from the Canadian Multicentre Osteoporosis Study (CaMos) Calgary cohort. High quality image pairs were selected and measurement precision was estimated by calculating the coefficient of variation (CV). Consistent with previous data, density parameters (e.g. total bone mineral density) are more robust than structural (e.g. trabecular number) or finite element parameters (e.g. failure load). To obtain acceptable measurement precision, images should not exceed a manual grading of 3 (on a scale from 1 to 5) or an automatic (ε(T)) grading of 1.2. Automatic and manual grading provide comparable quality control, but the advantage of the automated technique is its ability to provide a motion value at scan time (providing a basis for real time decision regarding re-scan requirements), and the assessment is objective. Notably, automatic motion measurement can be performed retrospectively based on original scan data, and is therefore well suited for multi-center studies as well as any research where objective quality control is paramount.

  7. Modulation of high quality factors in rolled-up microcavities

    NASA Astrophysics Data System (ADS)

    Fang, Yangfu; Li, Shilong; Mei, Yongfeng

    2016-09-01

    We systematically investigate the evolution of resonant modes in a rolled-up microcavity as the overlap length between structural notches increases, which presents a modulation behavior for high Q factors. The resonant modes in the rolled-up microcavity display a deterministic mode chirality, which is well correlated to the Q factor. We derive a two-mode non-Hermitian Hamiltonian to clarify these unusual findings. It reveals that strong resonant interactions of scattered waves between the structural notches are responsible for the high mode chirality (thus high Q factor) and its modulation behavior in rolled-up microcavities.

  8. Transient cavitation in high-quality-factor resonators at high static pressures.

    PubMed

    Gaitan, D Felipe; Tessien, Ross A; Hiller, Robert A; Gutierrez, Joel; Scott, Corey; Tardif, Henry; Callahan, Brant; Matula, Thomas J; Crum, Lawrence A; Holt, R Glynn; Church, Charles C; Raymond, Jason L

    2010-06-01

    It is well known that cavitation collapse can generate intense concentrations of mechanical energy, sufficient to erode even the hardest metals and to generate light emissions visible to the naked eye [sonoluminescence (SL)]. Considerable attention has been devoted to the phenomenon of "single bubble sonoluminescence" (SBSL) in which a single stable cavitation bubble radiates light flashes each and every acoustic cycle. Most of these studies involve acoustic resonators in which the ambient pressure is near 0.1 MPa (1 bar), and with acoustic driving pressures on the order of 0.1 MPa. This study describes a high-quality factor, spherical resonator capable of achieving acoustic cavitation at ambient pressures in excess of 30 MPa (300 bars). This system generates bursts of violent inertial cavitation events lasting only a few milliseconds (hundreds of acoustic cycles), in contrast with the repetitive cavitation events (lasting several minutes) observed in SBSL; accordingly, these events are described as "inertial transient cavitation." Cavitation observed in this high pressure resonator is characterized by flashes of light with intensities up to 1000 times brighter than SBSL flashes, as well as spherical shock waves with amplitudes exceeding 30 MPa at the resonator wall. Both SL and shock amplitudes increase with static pressure.

  9. Cost-effective multi-camera array for high quality video with very high dynamic range

    NASA Astrophysics Data System (ADS)

    Keinert, Joachim; Wetzel, Marcus; Schöberl, Michael; Schäfer, Peter; Zilly, Frederik; Bätz, Michel; Fößel, Siegfried; Kaup, André

    2014-03-01

    Temporal bracketing can create images with higher dynamic range than the underlying sensor. Unfortunately, moving objects cause disturbing artifacts. Moreover, the combination with high frame rates is almost unachiev­ able since a single video frame requires multiple sensor readouts. The combination of multiple synchronized side-by-side cameras equipped with different attenuation filters promises a remedy, since all exposures can be performed at the same time with the same duration using the playout video frame rate. However, a disparity correction is needed to compensate the spatial displacement of the cameras. Unfortunately, the requirements for a high quality disparity correction contradict the goal to increase dynamic range. When using two cameras, disparity correction needs objects to be properly exposed in both cameras. In contrast, a dynamic range in­crease needs the cameras to capture different luminance ranges. As this contradiction has not been addressed in literature so far, this paper proposes a novel solution based on a three camera setup. It enables accurate de­ termination of the disparities and an increase of the dynamic range by nearly a factor of two while still limiting costs. Compared to a two camera solution, the mean opinion score (MOS) is improved by 13.47 units in average for the Middleburry images.

  10. Clitoria ternatea L. as a Potential High Quality Forage Legume

    PubMed Central

    Abreu, Matheus Lima Corrêa; Vieira, Ricardo Augusto Mendonça; Rocha, Norberto Silva; Araujo, Raphael Pavesi; Glória, Leonardo Siqueira; Fernandes, Alberto Magno; de Lacerda, Paulo Drude; Júnior, Antonio Gesualdi

    2014-01-01

    Samples of Clitoria ternatea L. (Cunhã) were harvested at 35, 50, 70, and 90 d after a uniformity harvest in a field study designed as a completely randomized design with a total of 18 experimental plots. The dry matter yield of the whole plant was separated quantitatively into leaves, stems, and pods at each harvesting age. Chemical analyses and in vitro gas production kinetics were performed to assess the quality of the plant parts. Yields, chemical composition, and estimates of gas production parameters were analyzed by fitting a mixed statistical model with two types of covariance structures as follows: variance components and an unrestricted structure with heterogeneous variances. Fast and slow gas yielding pools were detected for both leaves and stems, but only a single pool was detected for pods. The homoscedasticity assumption was more likely for all variables, except for some parameters of the gas production kinetics of leaves and stems. There was no presence of typical pods at 35 and 50 d. In the leaves, the fibrous fractions were affected, whereas the non-fibrous fractions were unaffected by the harvesting age. The harvesting age affected the majority of the chemical constituents and gas kinetic parameters related to the stems. The leaves of this legume were the least affected part by the aging process. PMID:25049940

  11. Clitoria ternatea L. as a Potential High Quality Forage Legume.

    PubMed

    Abreu, Matheus Lima Corrêa; Vieira, Ricardo Augusto Mendonça; Rocha, Norberto Silva; Araujo, Raphael Pavesi; Glória, Leonardo Siqueira; Fernandes, Alberto Magno; de Lacerda, Paulo Drude; Júnior, Antonio Gesualdi

    2014-02-01

    Samples of Clitoria ternatea L. (Cunhã) were harvested at 35, 50, 70, and 90 d after a uniformity harvest in a field study designed as a completely randomized design with a total of 18 experimental plots. The dry matter yield of the whole plant was separated quantitatively into leaves, stems, and pods at each harvesting age. Chemical analyses and in vitro gas production kinetics were performed to assess the quality of the plant parts. Yields, chemical composition, and estimates of gas production parameters were analyzed by fitting a mixed statistical model with two types of covariance structures as follows: variance components and an unrestricted structure with heterogeneous variances. Fast and slow gas yielding pools were detected for both leaves and stems, but only a single pool was detected for pods. The homoscedasticity assumption was more likely for all variables, except for some parameters of the gas production kinetics of leaves and stems. There was no presence of typical pods at 35 and 50 d. In the leaves, the fibrous fractions were affected, whereas the non-fibrous fractions were unaffected by the harvesting age. The harvesting age affected the majority of the chemical constituents and gas kinetic parameters related to the stems. The leaves of this legume were the least affected part by the aging process.

  12. Large-scale high quality glass microlens arrays fabricated by laser enhanced wet etching.

    PubMed

    Tong, Siyu; Bian, Hao; Yang, Qing; Chen, Feng; Deng, Zefang; Si, Jinhai; Hou, Xun

    2014-11-17

    Large-scale high quality microlens arrays (MLAs) play an important role in enhancing the imaging quality of CCD and CMOS as well as the light extraction efficiency of LEDs and OLEDs. To meet the requirement in MLAs' wide application areas, a rapid fabrication method to fabricate large-scale MLAs with high quality, high fill factor and high uniformity is needed, especially on the glass substrate. In this paper, we present a simple and cost-efficient approach to the development of both concave and convex large-scale microlens arrays (MLAs) by using femtosecond laser wet etching method and replication technique. A large-scale high quality square-shaped microlens array with 512 × 512 units was fabricated.The unit size is 20 × 20 μm² on the whole scale of 1 × 1 cm². Its perfect uniformity and optical performance are demonstrated.

  13. Isolation of high quality RNA from Phyllanthus emblica and its evaluation by downstream applications.

    PubMed

    Kumar, Avneesh; Singh, Kashmir

    2012-11-01

    Next generation sequencing is a high-throughput technique widely used for transcriptome profiling. Isolation of high quality RNA is a prerequisite for such large scale transcriptome analysis. Phyllanthus emblica is an important medicinal plant having high amount of metabolites like vitamin C, flavonoids, polyphenolic compounds, tannins, which are responsible for its wondered medicinal properties. High concentration of secondary metabolites like polysaccharides and polyphenols proved to be an obstacle in isolating RNA of good quality. Any compromise with quality of RNA affects the downstream applications and requires extra cleaning steps that further reduce RNA quantity. We have developed a protocol for isolation of high quality RNA from P. embilca. RNA was successfully assessed for downstream applications like reverse transcription polymerase chain reaction, rapid amplification of cDNA ends, mRNA library preparation, and sequencing using HiSeq(™) 2000 sequencing technology. The protocol is simple and can be completed in 4-5 h.

  14. Health-related quality of life in children with high-functioning autism.

    PubMed

    Potvin, Marie-Christine; Snider, Laurie; Prelock, Patricia A; Wood-Dauphinee, Sharon; Kehayia, Eva

    2015-01-01

    The health-related quality of life of school-aged children with high-functioning autism is poorly understood. The objectives of this study were to compare the health-related quality of life of children with high-functioning autism to that of typically developing peers and to compare child-self and parent-proxy reports of health-related quality of life of children. A cross-sectional study of children with high-functioning autism (n = 30) and peers (n = 31) was conducted using the Pediatric Quality of Life Inventory 4.0 Generic Core Scales. Children with high-functioning autism had significantly poorer health-related quality of life than peers whether reported by themselves (p < .001) or their parents (p < .001), although disagreement (intra-class coefficient = -.075) between children and parental scores suggested variance in points of view. This study specifically investigated health-related quality of life in children with high-functioning autism as compared to a sample of peers, from the child's perspective. It strengthens earlier findings that children with high-functioning autism experience poorer health-related quality of life than those without this disorder and points to the importance of clinicians working with families to identify areas in a child's life that promote or hinder their sense of well-being.

  15. A Prospective, Descriptive, Quality Improvement Study to Investigate the Impact of a Turn-and-Position Device on the Incidence of Hospital-acquired Sacral Pressure Ulcers and Nursing Staff Time Needed for Repositioning Patients.

    PubMed

    Hall, Kimberly D; Clark, Rebecca C

    2016-11-01

    Patients in critical care areas are at risk for developing hospital-acquired pressure ulcers (HAPUs) due to their physical conditions and limited ability to reposition themselves. A prospective, 2-phase quality improvement study was conducted from September to November 2011 and from February to April 2012 in 1 medical and 1 surgical ICU to investigate the impact of a turn-and-assist device on the incidence of HAPUs and the time and personnel required to reposition patients reported as person/minutes (staff x minutes). A consecutive, convenience sample of patients was selected from newly admitted ICU patients who were at least 18 years old, nonambulatory, and required 2 or more people to assist with turning and repositioning. Sociodemographic data (patient age, gender, height, weight, body mass index, incontinence status); total Braden score and subscores for Activity, Mobility, and Moisture on admission; length of ICU stay and ventilator days; and sacral pressure ulcer incidence and stage and turn-and-assist data were collected. Fifty (50) patients participated in each phase. In phase 1, standard care for positioning included pillows, underpads, standard low-air-loss beds and additional staff as required for turning. In phase 2, the study product replaced standard care repositioning products including pillows; and a larger disposable moisture-wicking underpad (included as part of the turn study project kit) was substituted for the smaller, standard moisture-wicking disposable underpad. Turning procedures were timed with a stopwatch. Data were collected for a total of 32 hours during the observation periods; all patients were followed from admission until discharge from the ICU for a maximum of 14 days. T-tests were used to compare patient characteristics and person-minutes needed for repositioning differences, and Fisher's exact test was used to compare the incidence of sacral HAPUs during phase 1 and phase 2 of the study. No statistically significant

  16. Bust economics: foragers choose high quality habitats in lean times

    PubMed Central

    Dickman, Christopher R.

    2016-01-01

    In environments where food resources are spatially variable and temporarily impoverished, consumers that encounter habitat patches with different food density should focus their foraging initially where food density is highest before they move to patches where food density is lower. Increasing missed opportunity costs should drive individuals progressively to patches with lower food density as resources in the initially high food density patches deplete. To test these expectations, we assessed the foraging decisions of two species of dasyurid marsupials (dunnarts: Sminthopsis hirtipes and S. youngsoni) during a deep drought, or bust period, in the Simpson Desert of central Australia. Dunnarts were allowed access to three patches containing different food densities using an interview chamber experiment. Both species exhibited clear preference for the high density over the lower food density patches as measured in total harvested resources. Similarly, when measuring the proportion of resources harvested within the patches, we observed a marginal preference for patches with initially high densities. Models analyzing behavioral choices at the population level found no differences in behavior between the two species, but models analyzing choices at the individual level uncovered some variation. We conclude that dunnarts can distinguish between habitat patches with different densities of food and preferentially exploit the most valuable. As our observations were made during bust conditions, experiments should be repeated during boom times to assess the foraging economics of dunnarts when environmental resources are high. PMID:26839751

  17. Hiring Highly Qualified Teachers Begins with Quality Interviews

    ERIC Educational Resources Information Center

    Clement, Mary C.

    2009-01-01

    School administrators have some tough hiring decisions to make, and an interview to select the most highly qualified applicants is critically important. Even before the mandates of No Child Left Behind, school administrators strove to hire the best new teachers. Competent, caring, qualified teachers are the keys to enhanced student achievement.…

  18. Bust economics: foragers choose high quality habitats in lean times.

    PubMed

    Bleicher, Sonny S; Dickman, Christopher R

    2016-01-01

    In environments where food resources are spatially variable and temporarily impoverished, consumers that encounter habitat patches with different food density should focus their foraging initially where food density is highest before they move to patches where food density is lower. Increasing missed opportunity costs should drive individuals progressively to patches with lower food density as resources in the initially high food density patches deplete. To test these expectations, we assessed the foraging decisions of two species of dasyurid marsupials (dunnarts: Sminthopsis hirtipes and S. youngsoni) during a deep drought, or bust period, in the Simpson Desert of central Australia. Dunnarts were allowed access to three patches containing different food densities using an interview chamber experiment. Both species exhibited clear preference for the high density over the lower food density patches as measured in total harvested resources. Similarly, when measuring the proportion of resources harvested within the patches, we observed a marginal preference for patches with initially high densities. Models analyzing behavioral choices at the population level found no differences in behavior between the two species, but models analyzing choices at the individual level uncovered some variation. We conclude that dunnarts can distinguish between habitat patches with different densities of food and preferentially exploit the most valuable. As our observations were made during bust conditions, experiments should be repeated during boom times to assess the foraging economics of dunnarts when environmental resources are high.

  19. Technology's Achilles Heel: Achieving High-Quality Implementation

    ERIC Educational Resources Information Center

    Hall, Gene E.

    2010-01-01

    An inherent characteristic of technology education is the continual development of new technologies and creating innovative applications of already existing technologies. As exciting as these innovations can be, technology educators and school staffs are frequently challenged to accomplish high levels of implementation. The metaphor of the…

  20. Methods for Acquiring Structural MRI Data in Very Young Children with Autism without the Use of Sedation

    ERIC Educational Resources Information Center

    Nordahl, Christine Wu; Simon, Tony J.; Zierhut, Cynthia; Solomon, Marjorie; Rogers, Sally J.; Amaral, David G.

    2008-01-01

    We describe a protocol with which we achieved a 93% success rate in acquiring high quality MRI scans without the use of sedation in 2.5-4.5 year old children with autism, developmental delays, and typical development. Our main strategy was to conduct MRIs during natural nocturnal sleep in the evenings after the child's normal bedtime.…

  1. Building a High-Quality Teaching Profession: Lessons from around the World

    ERIC Educational Resources Information Center

    OECD Publishing (NJ1), 2011

    2011-01-01

    The "International Summit on the Teaching Profession" brings together education ministers, union leaders and other teacher leaders from high-performing and rapidly improving education systems to review how best to improve teacher quality and the quality of teaching and learning. This background report, taking up the four themes of the summit in…

  2. Relationships of cotton fiber properties to ring-spun yarn quality on selected High Plains cottons

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The objective of this research was to evaluate the adequacy of High Volume Instruement (HVI) and Advanced Fiber Information System (AFIS) fiber quality parameters for predicting quality parameters of ring-spun yarns considering differences in harvest method. Fiber properties measured using the HVI (...

  3. Representations of a High-Quality System of Undergraduate Education in English Higher Education Policy Documents

    ERIC Educational Resources Information Center

    Ashwin, Paul; Abbas, Andrea; McLean, Monica

    2015-01-01

    This article examines the ways in which a high-quality system of undergraduate education is represented in recent policy documents from a range of actors interested in higher education. Drawing on Basil Bernstein's ideas, the authors conceptualise the policy documents as reflecting a struggle over competing views of quality that are expressed…

  4. The Role of Central Level Staff in Supporting High Quality Instruction

    ERIC Educational Resources Information Center

    Gamble, Matthew Tanner

    2013-01-01

    The central office manages and directs a school system. In the wake of district and school reforms, the impact of the central office on schools and quality instruction has not been fully dissected. This study explores the role of the central office in the support of high quality instruction. Further, it analyzes the perceptions of those central…

  5. High Performance Work Systems and Organizational Outcomes: The Mediating Role of Information Quality.

    ERIC Educational Resources Information Center

    Preuss, Gil A.

    2003-01-01

    A study of the effect of high-performance work systems on 935 nurses and 182 nurses aides indicated that quality of decision-making information depends on workers' interpretive skills and partially mediated effects of work design and total quality management on organizational performance. Providing relevant knowledge and opportunities to use…

  6. A Project to Enhance Superintendents' Knowledge and Application of Characteristics of High Quality Teachers

    ERIC Educational Resources Information Center

    Pummill, Bret L.; Edson, Jerry C.; Loftin, Michelle M.; Robinson, Matthew A.

    2011-01-01

    This report describes a problem based learning project focusing on superintendents' knowledge of the characteristics of high quality teachers. Current research findings offer evidence teacher quality is an important school variable related to student achievement. School district leaders are faced with the problem of identifying the characteristics…

  7. Tapping the Potential: Retaining and Developing High-Quality New Teachers

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    There is growing consensus that the single most important factor in determining student performance is the quality of the teacher. Therefore, if the national goal of providing an equitable education to children across this nation is to be met, it is critical that efforts be concentrated on developing and retaining high-quality teachers in every…

  8. Preparing and Licensing High Quality Teachers in Pacific Region Jurisdictions. Issues & Answers. REL 2007-No. 031

    ERIC Educational Resources Information Center

    Heine, Hilda C.; Emesiochl, Masa Akii

    2007-01-01

    The provisions of the No Child Left Behind Act (NCLB) of 2001 for teacher quality direct that all students in U.S. public schools be taught by highly qualified teachers. Although the Pacific Region entities are trying to meet this teacher-quality mandate, most are still far from fulfilling the minimum education requirements for their teachers. By…

  9. Recycle food wastes into high quality fish feeds for safe and quality fish production.

    PubMed

    Wong, Ming-Hung; Mo, Wing-Yin; Choi, Wai-Ming; Cheng, Zhang; Man, Yu-Bon

    2016-12-01

    The amount of food waste generated from modern societies is increasing, which has imposed a tremendous pressure on its treatment and disposal. Food waste should be treated as a valuable resource rather than waste, and turning it into fish feeds would be a viable alternative. This paper attempts to review the feasibility of using food waste to formulate feed pellets to culture a few freshwater fish species, such as grass carp, grey mullet, and tilapia, under polyculture mode (growing different species in the same pond). These species occupy different ecological niches, with different feeding modes (i.e., herbivorous, filter feeding, etc.), and therefore all the nutrients derived from the food waste could be efficiently recycled within the ecosystem. The problems facing environmental pollution and fish contamination; the past and present situation of inland fish culture (focusing on South China); upgrade of food waste based feed pellets by adding enzymes, vitamin-mineral premix, probiotics (yeast), prebiotics, and Chinese medicinal herbs into feeds; and potential health risks of fish cultivated by food waste based pellets are discussed, citing some local examples. It can be concluded that appropriate portions of different types of food waste could satisfy basic nutritional requirements of lower trophic level fish species such as grass carp and tilapia. Upgrading the fish pellets by adding different supplements mentioned above could further elevated the quality of feeds, leading to higher growth rates, and enhanced immunity of fish. Health risk assessments based on the major environmental contaminants (mercury, PAHs and DDTs) in fish flesh showed that fish fed food waste based pellets are safer for consumption, when compared with those fed commercial feed pellets.

  10. High quality epoxysilane substrate for clinical multiplex serodiagnostic proteomic microarrays

    NASA Astrophysics Data System (ADS)

    Ewart, Tom; Carmichael, Stuart; Lea, Peter

    2005-09-01

    Polylysine and aminopropylsilane treated glass comprised the majority of substrates employed in first generation genetic microarray substrates. Second generation single stranded long oligo libraries with amino termini provided for controlled terminal specific attachment, and rationally designed unique sequence libraries with normalized melting temperatures. These libraries benefit from active covalent coupling surfaces such as Epoxysilane. The latter's oxime ring shows versatile reactivity with amino-, thiol- and hydroxyl- groups thus encompassing small molecule, oligo and proteomic microarray applications. Batch-to-batch production uniformity supports entry of the Epoxysilane process into clinical diagnostics. We carried out multiple print runs of 21 clinically relevant bacterial and viral antigens at optimized concentrations, plus human IgG and IgM standards in triplicate on multiple batches of Epoxysilane substrates. A set of 45 patient sera were assayed in a 35 minute protocol using 10 microliters per array in a capillary-fill format (15 minute serum incubation, wash, 15 minute incubation with Cy3-labeled anti-hIgG plus Dy647-labeled anti-hIgM, final wash). The LOD (3 SD above background) was better than 1 microgram/ml for IgG, and standard curves were regular and monotonically increasing over the range 0 to 1000 micrograms/ml. Ninety-five percent of the CVs for the standards were under 10%, and 90% percent of CVs for antigen responses were under 10% across all batches of Epoxysilane and print runs. In addition, where SDs are larger than expected, microarray images may be readily reviewed for quality control purposes and pin misprints quickly identified. In order to determine the influence of stirring on sensitivity and speed of the microarray assay, we printed 10 common ToRCH antigens (H. pylori, T. gondii, Rubella, Rubeola, C. trachomatis, Herpes 1 and 2, CMV, C. jejuni, and EBV) in Epoxysilane-activated slide-wells. Anti-IgG-Cy3 direct binding to printed Ig

  11. Rapid extraction of three instantaneous attributes in the application of high-density on-site seismic acquisition data quality control

    NASA Astrophysics Data System (ADS)

    Zhang, Y.; Tong, S.; Wang, L.; Li, L.

    2015-12-01

    It is very important to evaluate the quality of the acquired high-density seismic data on-site acquisition. Fast、quantitative data analysis method can help on-site quality control personnel to monitor the quality of data conveniently. It can also estimate the distribution characteristics of abnormal data. We can adjust the construction parameters in time and guide the on-site acquisition work based on the results of the analysis.Mass data have been acquired by high-density seismic acquisition. Work-load of on-site data analysis and process is increasing because of mass data. We need to analyze the quality of the data quickly and improve the accuracy of the result. In normal seismic data on-site acquisition, on-site quality control personnel usually use qualitative method to analyze seismic data so the analyzing result is affected by the experience of quality control personnel. On-site seismic data analysis method gradually develops from qualitative to quantitative. Now we estimate the quality of seismic data by statistical characters instead of experience. The result of estimate is more reliable.On-site processing software has some analysis method like amplitude analysis, frequency analysis, autocorrelation analysis, F-K analysis and so on. We can estimate the quality of seismic data based on the quantitative process. We can also use a simple method to get the three instantaneous attributes if we transform seismic data to complex domain. On-site seismic data can be analyzed and estimated by applicable attributes (e.g. instantaneous amplitude can be used to find out abnormal trace; quality control personnel can analyze the propagation of the wave field by instantaneous phase because both strong and weak signal can be displayed on the instantaneous phase diagram; Instantaneous frequency could reflect the frequency values of every moment, it can estimate the distribution of on-site seismic data's frequency characteristics quantitative). Transforming seismic data to

  12. Space Acquired Photography

    USGS Publications Warehouse

    ,

    2008-01-01

    Interested in a photograph of the first space walk by an American astronaut, or the first photograph from space of a solar eclipse? Or maybe your interest is in a specific geologic, oceanic, or meteorological phenomenon? The U.S. Geological Survey (USGS) Earth Resources Observation and Science (EROS) Center is making photographs of the Earth taken from space available for search, download, and ordering. These photographs were taken by Gemini mission astronauts with handheld cameras or by the Large Format Camera that flew on space shuttle Challenger in October 1984. Space photographs are distributed by EROS only as high-resolution scanned or medium-resolution digital products.

  13. Space acquired photography

    USGS Publications Warehouse

    ,

    2008-01-01

    Interested in a photograph of the first space walk by an American astronaut, or the first photograph from space of a solar eclipse? Or maybe your interest is in a specific geologic, oceanic, or meteorological phenomenon? The U.S. Geological Survey (USGS) Earth Resources Observation and Science (EROS) Center is making photographs of the Earth taken from space available for search, download, and ordering. These photographs were taken by Gemini mission astronauts with handheld cameras or by the Large Format Camera that flew on space shuttle Challenger in October 1984. Space photographs are distributed by EROS only as high-resolution scanned or medium-resolution digital products.

  14. The use of ion beam cleaning to obtain high quality cold welds with minimal deformation

    NASA Technical Reports Server (NTRS)

    Sater, B. L.; Moore, T. J.

    1978-01-01

    A variation of cold welding is described which utilizes an ion beam to clean mating surfaces prior to joining in a vacuum environment. High quality solid state welds were produced with minimal deformation.

  15. High quality entanglement on a chip-based frequency comb.

    PubMed

    Mazeas, F; Traetta, M; Bentivegna, M; Kaiser, F; Aktas, D; Zhang, W; Ramos, C A; Ngah, L A; Lunghi, T; Picholle, É; Belabas-Plougonven, N; Le Roux, X; Cassan, É; Marris-Morini, D; Vivien, L; Sauder, G; Labonté, L; Tanzilli, S

    2016-12-12

    We report an efficient energy-time entangled photon-pair source based on four-wave mixing in a CMOS-compatible silicon photonics ring resonator. Thanks to suitable optimization, the source shows a large spectral brightness of 400 pairs of entangled photons /s/MHz for 500 μW pump power, compatible with standard telecom dense wavelength division multiplexers. We demonstrate high-purity energy-time entanglement, i.e., free of photonic noise, with near perfect raw visibilities (> 98%) between various channel pairs in the telecom C-band. Such a compact source stands as a path towards more complex quantum photonic circuits dedicated to quantum communication systems.

  16. Intense high-quality medical proton beams via laser fields.

    PubMed

    Galow, Benjamin J; Harman, Zoltán; Keitel, Christoph H

    2010-12-06

    Simulations based on the coupled relativistic equations of motion show that protons stemming from laser-plasma processes can be efficiently post-accelerated employing single and crossed pulsed laser beams focused to spot radii on the order of the laser wavelength. We demonstrate that the crossed beams produce quasi-monoenergetic accelerated protons with kinetic energies exceeding 200 MeV, small energy spreads of about 1% and high densities as required for hadron cancer therapy. To our knowledge, this is the first scheme allowing for this important application based on an all-optical set-up.

  17. Probing high quality pentacene monolayers by optical methods

    NASA Astrophysics Data System (ADS)

    He, Rui; Tassi, Nancy G.; Blanchet, Graciela B.; Pinczuk, Aron

    2006-05-01

    We report optical studies of pentacene monolayers grown on poly-alpha-methyl-styrene (PAMS) substrates of high uniformity that reaches into the micron length-scale in the lateral dimension. Raman scattering intensities from a two-monolayer pentacene film exhibit large resonance enhancements when incoming and outgoing photon energies overlap the free exciton measured in optical emission. The incoming and outgoing resonance enhancements are of about the same strength. The free exciton optical emission band is sharp and intense, and it blue-shifts by about 85 meV from that of the pentacene single crystal.

  18. Crystal quality and inhibitor binding by aspartic proteinases; preparation of high quality crystals of mouse renin

    NASA Astrophysics Data System (ADS)

    Badasso, M.; Sibanda, B. L.; Cooper, J. B.; Dealwis, C. G.; Wood, S. P.

    1992-08-01

    Renin from mouse submandibular glands has been highly purified and co-crystallized with a synthetic nonapeptide fragment of rat angiotensionogen in which the scissile Leu-Leu bond has been modified as a hydroxyethylene mimic of the transition state. The strong diffraction from these crystals compared to the native form is discussed in relation to the behaviour of other members of the aspartic proteinase family in crystallisation.

  19. [Hospital-acquired urinary tract infections].

    PubMed

    Adukauskiene, Dalia; Cicinskaite, Ilona; Vitkauskiene, Astra; Macas, Andrius; Tamosiūnas, Ramūnas; Kinderyte, Aida

    2006-01-01

    Urinary tract infections are responsible for 40-60% of all hospital-acquired infections. Increased age of patients and comorbid diseases render hospitalized patients more susceptible to infection. Almost 80% of hospital-acquired urinary tract infections are associated with urinary catheters, and only 5-10% of urinary infections are caused by invasive manipulations in the urogenital tract. Pathogens of hospital-acquired urinary tract infections are frequently multi-resistant, and antibiotic therapy can only be successful when the complicating factors are eliminated or urodynamic function is restored. For treatment of complicated hospital-acquired urinary tract infections, the antibiotics must exhibit adequate pharmacodynamic and pharmacokinetic properties: high renal clearance of unmetabolized form with good antimicrobial activity in both acidic and alkaline urine. For selection of empirical treatment of hospital-acquired urinary tract infections, it is necessary to evaluate localization of infection, its severity, possible isolates, and the most frequent pathogens in the department where patient is treated. The best choice for the starting the antimicrobial therapy is the cheapest narrow-spectrum effective antibiotic in the treatment of urinary tract infection until microbiological evaluation of pathogens will be received. Adequate management of urinary tract infections lowers the rate of complications, requirements for antibacterial treatment, selection of multi-resistant isolates and is cost effective.

  20. A New Framework for Quality Assessment of High-Resolution Fingerprint Images.

    PubMed

    Teixeira, Raoni; Leite, Neucimar

    2016-11-22

    The quality assessment of sets of features extracted from patterns of epidermal ridges on our fingers is a biometric challenge problem with implications on questions concerning security, privacy and identity fraud. In this work, we introduced a new methodology to analyze the quality of high-resolution fingerprint images containing sets of fingerprint pores. Our approach takes into account the spatial interrelationship between the considered features and some basic transformations involving point process and anisotropic analysis. We proposed two new quality index algorithms following spatial and structural classes of analysis. These algorithms have proved to be effective as a performance predictor and as a filter excluding low-quality features in a recognition process. The experiments using error reject curves show that the proposed approaches outperform the state-of-the-art quality assessment algorithm for high-resolution fingerprint recognition, besides defining a new method for reconstructing their friction ridge phases in a very consistent way.

  1. Maternally acquired runt disease.

    PubMed

    Beer, A E; Billingham, R E

    1973-01-19

    Without altering the structural integrity of the placenta by irradiation or drugs, we have shown that it is possible to immunize females both adoptively and actively against the paternally inherited transplantation antigens of their fetuses. Such immunization causes a high incidence of runt disease among the litters. Although the putative chimeric status of the affected offspring has yet to be confirmed, the results of our experiments support the thesis that runt disease is caused by the activities of "unwanted" immigrant lymphocytes from the maternal circulation. Our results suggest that immunologically activated cells are more likely to cross the placenta than normal cells and that this greater mobility may not be related to the immunologic specificity of the activated cells. Two factors may have contributed to the apparent failure of numerous previous attempts to demonstrate the capacity of transplantation immunity to affect the well-being of a fetus or, more correctly, its placenta, in the way that might be expected of a homograft. (i) Investigators were preoccupied with obtaining a classic type of rejection, in utero, analogous to the rejection of an orthotopic skin homograft. The birth of consistently healthy-looking litters, interpreted as a failure of the experiment, convinced the investigators of the efficacy of nature's solution of the homograft problem and there was no reason for them to suspect its possible limitations. Observation of the litters for several weeks might have uncovered the phenomenon of maternally induced runt disease. (ii) Most investigators resorted to hyperimmunization of the mothers. This would have facilitated the synthesis of protective isoantibodies capable of interfering with the expression of the potentially harmful cellular immune response (6). Ever since the abnormalities of runt disease were first described they have repeatedly been compared to those observed in patients with certain lymphomas (17). Various theories have been

  2. Clinical laboratory data: acquire, analyze, communicate, liberate.

    PubMed

    Azzazy, Hassan M E; Elbehery, Ali H A

    2015-01-01

    The availability of portable healthcare devices, which can acquire and transmit medical data to remote experts would dramatically affect healthcare in areas with poor infrastructure. Smartphones, which feature touchscreen computer capabilities and sophisticated cameras, have become widely available with over billion units shipped in 2013. In the clinical laboratory, smartphones have recently brought the capabilities of key instruments such as spectrophotometers, fluorescence analyzers and microscopes into the palm of the hand. Several research groups have developed sensitive and low-cost smartphone-based diagnostic assay prototypes for testing cholesterol, albumin, vitamin D, tumor markers, and the detection of infectious agents. This review covers the use of smartphones to acquire, analyze, communicate, and liberate clinical laboratory data. Smartphones promise to dramatically improve the quality and quantity of healthcare offered in resource-limited areas.

  3. High pulse energy, high beam quality microsecond-pulse Ti:sapphire laser at 819.7 nm

    NASA Astrophysics Data System (ADS)

    Xu, Chang; Guo, Chuan; Yu, Hai-Bo; Wang, Zhi-Min; Zuo, Jun-Wei; Xia, Yuan-Qin; Bian, Qi; Bo, Yong; Gao, Hong-Wei; Guo, Ya-Ding; Zhang, Sheng; Cui, Da-Fu; Peng, Qin-Jun; Xu, Zu-Yan

    2017-03-01

    In this letter, a high pulse energy and high beam quality 819.7 nm Ti:sapphire laser pumped by a frequency-doubled Nd:YAG laser is demonstrated. At incident pump energy of 774 mJ, the maximum output energy of 89 mJ at 819.7 nm with a pulse width of 100 μs is achieved at a repetition rate of 5 Hz. To the best of our knowledge, this is the highest pulse energy at 819.7 nm with pulse width of hundred microseconds for a Ti:sapphire laser. The beam quality factor M 2 is measured to be 1.18. This specific wavelength with the high pulse energy and high beam quality at 819.7 nm is a promising light source to create a polychromatic laser guide star together with a home-made 589 nm laser via exciting the sodium atoms in the mesospheric atmosphere.

  4. High quality reprocessed GPS Zenith Total Delay dataset over Europe

    NASA Astrophysics Data System (ADS)

    Pacione, Rosa; Pace, Brigida; Bianco, Giuseppe

    2015-04-01

    The present availability of 18 years of GPS data belonging to the European Permanent Network (EPN, http://www.epncb.oma.be/) is a valuable database for the development of a climate data record of GPS tropospheric products. We homogeneously reprocessed the whole EPN network for the period 1996-2013 in a consistent way using GIPSY-OASIS II software and applying the state-of-the-art models. This ongoing reprocessing effort, part of the EPN Repro2 initiative, will provide a GPS climate data record over Europe with high potential for monitoring trend and variability in atmospheric water vapour thus improving the knowledge of climatic trends of atmospheric water vapour, being useful for global and regional NWP reanalyses and climate model simulations. These reprocessed ZTD time series will be evaluated against radiosonde data as well as independently reprocessed GPS ZTD time-series.

  5. Access High Quality Imagery from the NOAA View Portal

    NASA Astrophysics Data System (ADS)

    Pisut, D.; Powell, A. M.; Loomis, T.; Goel, V.; Mills, B.; Cowan, D.

    2013-12-01

    NOAA curates a vast treasure trove of environmental data, but one that is sometimes not easily accessed, especially for education, outreach, and media purposes. Traditional data portals in NOAA require extensive knowledge of the specific names of observation platforms, models, and analyses, along with nomenclature for variable outputs. A new website and web mapping service (WMS) from NOAA attempts to remedy such issues. The NOAA View data imagery portal provides a seamless entry point into data from across the agency: satellite, models, in-situ analysis, etc. The system provides the user with ability to browse, animate, and download high resolution (e.g., 4,000 x 2,000 pixel) imagery, Google Earth, and even proxy data files. The WMS architecture also allows the resources to be ingested into other software systems or applications.

  6. Extraction of high-quality RNA from germinating barley (Hordeum vulgare L.) seeds containing high levels of starch.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Comparative evaluation of gene expression levels can lead to improved understanding of the gene networks underlying traits of economic importance. Extraction of high-quality RNA from germinating barley seeds that contain high levels of starch is of vital importance for analysing the expression of ca...

  7. Ray tracing analysis of the image quality of a high collection efficiency mirror system.

    PubMed

    Seitzinger, N K; Martin, J C; Keller, R A

    1990-10-01

    Recently, a high collection efficiency mirror system was developed by Watson [Cytometry 10, 681-688 (1989)] to increase the sensitivity of low level fluorescence detection. The mirror system consists of an ellipsoidal imaging mirror and spherical backreflecting mirror. The fluorescing sample is located at one focus of the ellipsoid, and its image is formed at the other focus. In this paper we evaluate the image quality of this geometry using a PC-based ray tracing program. The analysis demonstrates high collection efficiency but poor image quality. The effect of poor image quality on single molecule detection is discussed.

  8. Ray tracing analysis of the image quality of a high collection efficiency mirror system

    SciTech Connect

    Seitzinger, N.K.; Martin, J.C.; Keller, R.A. )

    1990-10-01

    Recently, a high collection efficiency mirror system was developed by Watson (Cytometry, {bold 10}, 681--688 (1989)) to increase the sensitivity of low level fluorescence detection. The mirror system consists of an ellipsoidal imaging mirror and spherical backreflecting mirror. The fluorescing sample is located at one focus of the ellipsoid, and its image is formed at the other focus. In this paper we evaluate the image quality of this geometry using a PC-based ray tracing program. The analysis demonstrates high collection efficiency but poor image quality. The effect of poor image quality on single molecule detection is discussed. Keywords: Fluorescence, ellipsoidal mirror, spherical mirror, single molecule detection, flow cytometry.

  9. Natural Fatigue Crack Initiation and Detection in High Quality Spur Gears

    DTIC Science & Technology

    2012-06-01

    Natural Fatigue Crack Initiation and Detection in High Quality Spur Gears by David “Blake” Stringer, Ph.D., Kelsen E. LaBerge, Ph.D., Cory...0383 June 2012 Natural Fatigue Crack Initiation and Detection in High Quality Spur Gears David “Blake” Stringer and Ph.D., Kelsen E. LaBerge...Quality Spur Gears 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) David “Blake” Stringer, Ph.D., Kelsen E

  10. Explaining women's high satisfaction with objectively poor quality childbirth services: Armenia as a case study.

    PubMed

    Grigoryan, Ruzanna; Thompson, Michael E; Crape, Byron; Hekimian, Kim

    2015-01-01

    Despite documented low-quality care in Armenia, surveys document high ratings of patient satisfaction with health care services. We explored reasons for high satisfaction in Armenia despite poor quality. Twenty-five women who recently delivered participated in this qualitative study through in-depth interviews. Patients avoided critiquing health care services because of personal relationships with and respect for providers and fear of losing services. Although they shared an understanding of what quality care should be, many were satisfied because their low expectations were met. Further mixed methods research may explain this dissonance. Until then, patient satisfaction measures need careful, contextual interpretations.

  11. Impact of high pressure processing on the quality traits of starter-free Queso Fresco

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Queso Fresco (QF), a popular high-moisture, high-pH Hispanic cheese sold in the U.S., underwent high- pressure processing (HPP) to determine if this process, which has the potential to improve the safety of cheese, would alter its quality traits. Starter-free rennet-set QF (manufactured from pasteur...

  12. JAXA protein crystallization in space: ongoing improvements for growing high-quality crystals.

    PubMed

    Takahashi, Sachiko; Ohta, Kazunori; Furubayashi, Naoki; Yan, Bin; Koga, Misako; Wada, Yoshio; Yamada, Mitsugu; Inaka, Koji; Tanaka, Hiroaki; Miyoshi, Hiroshi; Kobayashi, Tomoyuki; Kamigaichi, Shigeki

    2013-11-01

    The Japan Aerospace Exploration Agency (JAXA) started a high-quality protein crystal growth project, now called JAXA PCG, on the International Space Station (ISS) in 2002. Using the counter-diffusion technique, 14 sessions of experiments have been performed as of 2012 with 580 proteins crystallized in total. Over the course of these experiments, a user-friendly interface framework for high accessibility has been constructed and crystallization techniques improved; devices to maximize the use of the microgravity environment have been designed, resulting in some high-resolution crystal growth. If crystallization conditions were carefully fixed in ground-based experiments, high-quality protein crystals grew in microgravity in many experiments on the ISS, especially when a highly homogeneous protein sample and a viscous crystallization solution were employed. In this article, the current status of JAXA PCG is discussed, and a rational approach to high-quality protein crystal growth in microgravity based on numerical analyses is explained.

  13. Restraint of range walk error in a Geiger-mode avalanche photodiode lidar to acquire high-precision depth and intensity information.

    PubMed

    Xu, Lu; Zhang, Yu; Zhang, Yong; Yang, Chenghua; Yang, Xu; Zhao, Yuan

    2016-03-01

    There exists a range walk error in a Geiger-mode avalanche photodiode (Gm-APD) lidar because of the fluctuation in the number of signal photoelectrons. To restrain this range walk error, we propose a new returning-wave signal processing technique based on the Poisson probability response model and the Gaussian functions fitting method. High-precision depth and intensity information of the target at the distance of 5 m is obtained by a Gm-APD lidar using a 6 ns wide pulsed laser. The experiment results show that the range and intensity precisions are 1.2 cm and 0.015 photoelectrons, respectively.

  14. Summary of results and conclusions based on analysis of volume imaging and high spectral resolution lidar data acquired during FIRE phase 1, part 1

    NASA Technical Reports Server (NTRS)

    Grund, Christian J.; Eloranta, E. W.

    1990-01-01

    The collection of long term global statistics on cloud cover may be most easily accomplished with satellite based observations; however, measurements derived from passive satellite retrieval methods must be calibrated and verified by in situ or ground based remote sensor observations. Verification is not straight forward, however, because the highly variable nature of cloud altitude, morphology, and optical characteristics complicates the scaling of point measurements to satellite footprint sized areas. This is particularly evident for cirrus clouds which may be organized on horizontal scales of 10's of meters to 8 km or more, and have optical depths ranging from less than .003 to greater than 3. Cirrus clouds can strongly influence earths' radiative balance, but, because they are often transmissive, cirrus clouds are difficult to detect and characterize from satellite measurements. Because of its precise ranging capabilities, spatial resolution and sensitivity, lidar observations have played an important role in the detection, depiction, and characterization of cirrus clouds. Some of the characteristics of cirrus clouds are summarized which observed the High Spectral Resolution and Volume Imaging Lidars during the phase 1 IFO and ETO periods.

  15. An approach to high speed ship ride quality simulation

    NASA Technical Reports Server (NTRS)

    Malone, W. L.; Vickery, J. M.

    1975-01-01

    The high speeds attained by certain advanced surface ships result in a spectrum of motion which is higher in frequency than that of conventional ships. This fact along with the inclusion of advanced ride control features in the design of these ships resulted in an increased awareness of the need for ride criteria. Such criteria can be developed using data from actual ship operations in varied sea states or from clinical laboratory experiments. A third approach is to simulate ship conditions using measured or calculated ship motion data. Recent simulations have used data derived from a math model of Surface Effect Ship (SES) motion. The model in turn is based on equations of motion which have been refined with data from scale models and SES of up to 101 600-kg (100-ton) displacement. Employment of broad band motion emphasizes the use of the simulators as a design tool to evaluate a given ship configuration in several operational situations and also serves to provide data as to the overall effect of a given motion on crew performance and physiological status.

  16. High quality absolute paleointensity data from Santa Fe, New Mexico

    NASA Astrophysics Data System (ADS)

    Jones, S. A.; Tauxe, L.; Blinman, E.; Genevey, A.

    2015-12-01

    Preliminary paleointensity experiments were conducted using the IZZI protocol on one hundred and fourteen specimens from fifty-seven baked pottery fragments collected from nine archaeological sites near Santa Fe, New Mexico. Twenty of these fragments passed our weakest selection criteria. Seven additional specimens were made from each passing fragment for further paleointensity experiments. The results of these second experiments indicate that the samples are mildly anisotropic, so anisotropy experiments were conducted to correct for this behavior. Experiments to determine the cooling rate correction will be completed to ensure the robustness of the dataset. Stylistic evidence, historical documentation, dendrochronology, and 14C analyses provide age constraints with up to decade resolution for the VADM results. The twenty pottery fragments analyzed span five distinct time periods between 1300 and 1900 AD. Our new results for each fragment differ slightly from those predicted by the cals3k.4b and arch3k models, suggesting the models require refinement. This is expected because there are few archaeomagnetic constraints on the models from this region. Future pottery fragments and burned adobe fragments from the New Mexico area will be analyzed for paleointensity and combined with our pottery fragment data set to create a high-resolution paleointensity curve for the recent archaeological time in the American Southwest.

  17. High-Alpha Handling Qualities Flight Research on the NASA F/A-18 High Alpha Research Vehicle

    NASA Technical Reports Server (NTRS)

    Wichman, Keith D.; Pahle, Joseph W.; Bahm, Catherine; Davidson, John B.; Bacon, Barton J.; Murphy, Patrick C.; Ostroff, Aaron J.; Hoffler, Keith D.

    1996-01-01

    A flight research study of high-angle-of-attack handling qualities has been conducted at the NASA Dryden Flight Research Center using the F/A-18 High Alpha Research Vehicle (HARV). The objectives were to create a high-angle-of-attack handling qualities flight database, develop appropriate research evaluation maneuvers, and evaluate high-angle-of-attack handling qualities guidelines and criteria. Using linear and nonlinear simulations and flight research data, the predictions from each criterion were compared with the pilot ratings and comments. Proposed high-angle-of-attack nonlinear design guidelines and proposed handling qualities criteria and guidelines developed using piloted simulation were considered. Recently formulated time-domain Neal-Smith guidelines were also considered for application to high-angle-of-attack maneuvering. Conventional envelope criteria were evaluated for possible extension to the high-angle-of-attack regime. Additionally, the maneuvers were studied as potential evaluation techniques, including a limited validation of the proposed standard evaluation maneuver set. This paper gives an overview of these research objectives through examples and summarizes result highlights. The maneuver development is described briefly, the criteria evaluation is emphasized with example results given, and a brief discussion of the database form and content is presented.

  18. The physical activity levels among people living with human immunodeficiency virus/acquired immunodeficiency syndrome receiving high active antiretroviral therapy in Rwanda.

    PubMed

    Frantz, J M; Murenzi, A

    2013-01-01

    The accessibility of high active antiretroviral therapy (HAART) for local human immunodeficiency virus (HIV) patients is improving in Rwanda. It is well known that this therapy is associated with serious adverse effects, such as metabolic and morphologic changes. One of the recommended preventive modalities for these complications is participation in physical activity. The current study aims to determine the anthropometric profile and physical activity levels among people living with HIV and receiving HAART in Kigali, Rwanda. The study was a cross-sectional, descriptive quantitative survey. The participant's levels of physical activity participation and their association with anthropometric profiles were measured, using a structured self-administered questionnaire for 407 clients passing through the clinics. Of the participants, approximately 70% were inactive and in addition, 40% were obese and 43% overweight. Obesity was found to be strongly associated with inactivity. Lack of motivation, and time as well as fear of worsening the disease were found to be barriers to participation in physical activity.

  19. Successful high-dose dexamethasone treatment of acquired pure red cell aplasia following ABO major mismatched allogeneic hematopoietic stem cell transplantation.

    PubMed

    Hiroshima, Yuki; Shiono, Yousuke; Suzuki, Ikuko; Yamamoto, Masakazu; Kato, Yuichi; Tajima, Katsushi; Kato, Takeo

    2016-06-01

    A 46-year-old man was diagnosed with acute myelomonocytic leukemia involving inv(16)(p13.1q22) in August 2007. He received a human leukocyte antigen-identical, ABO major-mismatched (donor: A, recipient: O) bone marrow transplantation from an unrelated donor in June 2009. Cyclosporin A (CsA) and short-course methotrexate were used for graft versus host disease prophylaxis. Although granulocyte and platelet engraftment were achieved, the patient exhibited persistent anemia and was dependent on red blood cell (RBC) transfusions. Bone marrow aspiration on day 63 revealed the near absence of erythroid precursors, a finding consistent with pure red cell aplasia. No CBFβ-MYH11 transcripts were detected. The recipient's anti-A IgM antibody titer was 1:64, and his anti-A IgG antibody titer was 1:1024. The discontinuation of CsA, and the initiation of rituximab and donor lymphocyte infusions were all ineffective against his anemia. He was treated with high-dose dexamethasone (DEXA) (40 mg/day DEXA, days 657-660, days 757-760; 20 mg/day DEXA, days 764-767, days 772-775) in April 2010. A follow-up examination performed at 7 months after the high-dose DEXA treatment showed the patient's anti-A antibody titer to have dropped to an undetectable level. His hemoglobin levels also returned to normal (Hb: 13.4 g/dl), and he no longer required RBC transfusions.

  20. Text categorization models for retrieval of high quality articles in internal medicine.

    PubMed

    Aphinyanaphongs, Y; Aliferis, C F

    2003-01-01

    The discipline of Evidence Based Medicine (EBM) studies formal and quasi-formal methods for identifying high quality medical information and abstracting it in useful forms so that patients receive the best customized care possible [1]. Current computer-based methods for finding high quality information in PubMed and similar bibliographic resources utilize search tools that employ preconstructed Boolean queries. These clinical queries are derived from a combined application of (a) user interviews, (b) ad-hoc manual document quality review, and (c) search over a constrained space of disjunctive Boolean queries. The present research explores the use of powerful text categorization (machine learning) methods to identify content-specific and high-quality PubMed articles. Our results show that models built with the proposed approach outperform the Boolean based PubMed clinical query filters in discriminatory power.

  1. Synthesizing High-Quality Graphene Membranes for Engineering Diffusion Barriers

    NASA Astrophysics Data System (ADS)

    Singha Roy, Susmit

    We demonstrate significant advances in the fundamental understanding and engineering of scalable graphene diffusion barriers. Experimental studies have established that defect-free non-scalable graphene is an excellent barrier material, however its scalable counterparts are still well behind in terms of performance. The latter's ability to perform as a barrier membrane is compromised primarily by the presence of three major problems - high density of defects, self-degradation in ambient environment and induced electrochemical oxidation of the underlying material. First, we develop an in-depth understanding of how diffusion occurs through monolayer graphene grown via chemical vapor deposition. It is shown that the atomic membrane is impenetrable in the pristine regions, however it is easily penetrated by oxygen and water at grain boundaries and intrinsic pinholes. Second, we study in detail the self-deterioration of graphene in ambient and quantify the evolution, kinetics, and energetics of the degradation process both in the pristine and intrinsically defective regions of graphene. It is also found that the degradation process is accelerated in the presence of water vapor. Third, we find that the overall defect density of a graphene membrane is primarily determined by the density of its intrinsic pinholes and grain boundaries. We demonstrate that the density on intrinsic pinholes can be significantly reduced by reducing the surface roughness of the growth substrate which is achieved by regulating the pre-growth annealing time and temperature. The density of the grain boundaries can be altered by varying the internucleation distance during the growth of the membrane. Fourth, when graphene is used as a corrosion barrier for metals, we establish that the electrochemical corrosion of the metal can be drastically reduced by adding an ultra-thin electrically insulating layer between the graphene and the metal. In addition, the barrier performance is enhanced greatly by

  2. The physical activity levels among people living with human immunodeficiency virus/acquired immunodeficiency syndrome receiving high active antiretroviral therapy in Rwanda

    PubMed Central

    Frantz, J.M.; Murenzi, A.

    2014-01-01

    The accessibility of high active antiretroviral therapy (HAART) for local human immunodeficiency virus (HIV) patients is improving in Rwanda. It is well known that this therapy is associated with serious adverse effects, such as metabolic and morphologic changes. One of the recommended preventive modalities for these complications is participation in physical activity. The current study aims to determine the anthropometric profile and physical activity levels among people living with HIV and receiving HAART in Kigali, Rwanda. The study was a cross-sectional, descriptive quantitative survey. The participant's levels of physical activity participation and their association with anthropometric profiles were measured, using a structured self-administered questionnaire for 407 clients passing through the clinics. Of the participants, approximately 70% were inactive and in addition, 40% were obese and 43% overweight. Obesity was found to be strongly associated with inactivity. Lack of motivation, and time as well as fear of worsening the disease were found to be barriers to participation in physical activity. PMID:24521093

  3. Foil-hole and data image quality assessment in 3DEM: Towards high-throughput image acquisition in the electron microscope.

    PubMed

    Vargas, J; Franken, E; Sorzano, C O S; Gomez-Blanco, J; Schoenmakers, R; Koster, A J; Carazo, J M

    2016-12-01

    Automatic or semiautomatic data collection approaches on a transmission electron microscope (TEM) for Single Particle Analysis, capable of acquiring large datasets composed of only high quality images, are of great importance to obtain 3D density maps with the highest resolution possible. Typically, this task is performed by an experienced microscopist, who manually decides to keep or discard images according to subjective criteria. Therefore, this methodology is slow, intensive in human work and subjective. In this work, we propose a method to automatically or semiautomatically perform this image selection task. The approach is based on some simple, fast and effective image quality descriptors, which can be computed during acquisition, to characterize foil-hole and data images. The proposed approach has been used to evaluate the quality of different datasets consisting of foil-hole and data images obtained with a FEI Titan Krios electron microscope. The results show that the proposed method is very effective evaluating the quality of foil-hole and data images, as well as predicting the quality of the data images from the foil-hole images.

  4. Bullying as a Risk for Poor Sleep Quality among High School Students in China

    PubMed Central

    Lu, Ci-yong; Deng, Jian-xiong; Huang, Jing-hui; Huang, Guo-liang; Deng, Xue-qing; Gao, Xue

    2015-01-01

    Objective To determine whether involvement in bullying as a bully, victim, or bully-victim was associated with a higher risk of poor sleep quality among high school students in China. Methods A cross-sectional study was conducted. A total of 23,877 high school students were surveyed in six cities in Guangdong Province. All students were asked to complete the adolescent health status questionnaire, which included the Chinese version of the Pittsburgh Sleep Quality Index (PSQI) and bullying involvement. Descriptive statistics were used to evaluate sleep quality and the prevalence of school bullying. Multi-level logistic regression analyses were conducted to examine the association between being victimized and bullying others with sleep quality. Results Among the 23,877 students, 6,127 (25.66%) reported having poor sleep quality, and 10.89% reported being involved in bullying behaviors. Of the respondents, 1,410 (5.91%) were pure victims of bullying, 401 (1.68%) were bullies and 784 (3.28%) were bully-victims. Frequently being involved in bullying behaviors (being bullied or bullying others) was related to increased risks of poor sleep quality compared with adolescents who were not involved in bullying behaviors. After adjusting for age, sex, and other confounding factors, the students who were being bullied (OR=2.05, 95%CI=1.81-2.32), bullied others (OR=2.30, 95%CI=1.85-2.86) or both (OR=2.58, 95%CI=2.20-3.03) were at a higher risk for poor sleep quality. Conclusions Poor sleep quality among high school students is highly prevalent, and school bullying is prevalent among adolescents in China. The present results suggested that being involved in school bullying might be a risk factor for poor sleep quality among adolescents. PMID:25811479

  5. Development of a high-precision image-processing automatic measurement system for MRI visceral fat images acquired using a binomial RF-excitation pulse.

    PubMed

    Nakai, Ryusuke; Azuma, Takashi; Kishimoto, Taizou; Hirata, Tazuko; Takizawa, Osamu; Hyon, Suong-Hyu; Tsutsumi, Sadami

    2010-05-01

    Development of a rapid and accurate method for visceral fat measurement is an important task, given the recent increase in the number of patients with metabolic syndrome. In this study, we optimized the Fast Low Angle Shot (FLASH) sequence using a binominal radiofrequency excitation pulse, in which the acquisition time is short, and measured changes in the amount of visceral fat in subjects after a period of wearing clothes with a fat-reducing effect during walking. We solved the reproducibility problem associated with the number of slices, and developed automatic measurement software for high-precision separation and extraction of abdominal visceral fat images. This software was developed using intensity correction with the coil position, derivation of a threshold by histogram analysis and fat separation by template matching for abdominal images. The cross-sectional area of a single slice varies for every acquisition due to visceral organ movement, but the relative error largely converged for seven slices. The measured amount of abdominal fat tended to be consistent with changes in the body fat and waist circumference of the subjects. The correlation coefficients between automatic extraction using the measurement software and manual extraction were 0.9978 for subcutaneous fat and 0.9972 for visceral fat, showing very strong positive correlations. The consistency rates were 0.9502+/-0.0167 for subcutaneous fat and 0.9395+/-0.0147 for visceral fat, and the shapes of the regions were also extracted very accurately. These results show that the magnetic resonance imaging acquisition method and image processing system developed in this study are beneficial for measurement of abdominal visceral fat. Therefore, this method may have a major role in future diagnosis of metabolic syndrome.

  6. High aspect ratio, high-quality microholes in PMMA: a comparison between femtosecond laser drilling in air and in vacuum

    NASA Astrophysics Data System (ADS)

    Xia, Bo; Jiang, Lan; Li, Xiaowei; Yan, Xueliang; Zhao, Weiwei; Lu, Yongfeng

    2015-04-01

    Microholes, especially high aspect ratio, high-quality microholes with small diameters (<100 μm), have broad applications. However, it is very difficult for traditional drilling methods to obtain deep microholes, especially with aspect ratios of over 50:1. Femtosecond lasers provide a promising solution for efficient drilling of deep microholes with high-precision material removal, reduced recast/microcracks, minimized heat-affected zones, and the absence of plasma-shielding effects. In this work, a comparison study of high aspect ratio, high-quality microholes fabricated in a poly(methyl methacrylate) (PMMA) bulk substrate with the ambient pressure adjusted from 105 Pa (air) down to 1 Pa (vacuum) is presented. High aspect ratio (over 100:1) microholes were obtained in a vacuum environment. The contrast between microhole evolution in air and in vacuum was investigated. The results indicate that efficient energy propagation and easy ejection of ablated material/plasma are probably the most important benefits of drilling microholes in vacuum. The dependence of microhole shapes on different fabrication parameters, including pulse energy and ambient pressure, was investigated to quantitatively reveal the underlying mechanisms. The enhanced drilling effect in vacuum was only found in a high pulse energy region ( E p > 20 μJ), and it becomes saturated when the ambient pressure was reduced to ~102 Pa at a pulse energy of 50 μJ. Drilling microholes in a vacuum provides a simple and effective way of rapidly fabricating high aspect ratio, high-quality microholes.

  7. Association between RR interval and high-frequency heart rate variability acquired during short-term, resting recordings with free and paced breathing.

    PubMed

    Sandercock, Gavin; Gladwell, Valerie; Dawson, Samantha; Nunan, David; Brodie, David; Beneke, Ralph

    2008-07-01

    High-frequency (HF) oscillations in RR interval from 0.15-0.40 Hz are widely accepted as a measure of cardiac vagal outflow but the HF/RR relationship appears complex, particularly with longer RR intervals. The aim of this study was to evaluate the HF/RR interval relationship during free and paced breathing. HF power and mean RR interval length were recorded in 150 men and 120 women (mean age 34.5 +/- 11.4) during 5 min of supine rest with either free or paced (12 cycles min(-1)) breathing. Linear and quadratic models were used to assess the relationship between RR interval and the natural logarithm of HF power (lnHF). The RR interval length at which there was no further increase in lnHF was determined as the deflection point. ANCOVA was used to determine differences in the linear regression slopes for lnHF/RR with paced or free breathing. With free breathing (n = 131), the adjusted R(2) was similar between linear (15.3%) and quadratic (17.5%) fits and saturation of lnHF occurred within the recorded RR interval range (1326 ms). With paced breathing (n = 139), adjusted R(2) values were again similar between linear (22.4%) and quadratic (23.2%) fits. The deflection point was outside the range of recorded RR intervals at 1458 ms. ANCOVA showed a significant difference in the slope of the lnHF/RR regression lines between free and paced breathing. The lnHF/RR relationship is weaker when derived from between-subject recordings than from repeated within-subject samples. lnHF/RR showed evidence of saturation at approximately 45 bpm with free breathing. With paced breathing, a deflection in lnHF was found outside the recorded RR interval range ( approximately 41 bpm). Paced breathing creates a stronger lnHF/RR relationship. The slope of the lnHF/RR regression line with paced breathing is significantly different from that observed with free breathing. It appears that lnHF is a valid index of vagal outflow, except in subjects with very low heart rates. Paced breathing data

  8. Certifying leaders? high-quality management practices and healthy organisations: an ISO-9000 based standardisation approach.

    PubMed

    Montano, Diego

    2016-08-05

    The present study proposes a set of quality requirements to management practices by taking into account the empirical evidence on their potential effects on health, the systemic nature of social organisations, and the current conceptualisations of management functions within the framework of comprehensive quality management systems. Systematic reviews and meta-analyses focusing on the associations between leadership and/or supervision and health in occupational settings are evaluated, and the core elements of an ISO 9001 standardisation approach are presented. Six major occupational health requirements to high-quality management practices are identified pertaining to communication processes, organisational justice, role clarity, decision making, social influence processes and management support. It is concluded that the quality of management practices may be improved by developing a quality management system of management practices that ensures not only conformity to product but also to occupational safety and health requirements. Further research may evaluate the practicability of the proposed approach.

  9. Certifying leaders? high-quality management practices and healthy organisations: an ISO-9000 based standardisation approach

    PubMed Central

    MONTANO, Diego

    2016-01-01

    The present study proposes a set of quality requirements to management practices by taking into account the empirical evidence on their potential effects on health, the systemic nature of social organisations, and the current conceptualisations of management functions within the framework of comprehensive quality management systems. Systematic reviews and meta-analyses focusing on the associations between leadership and/or supervision and health in occupational settings are evaluated, and the core elements of an ISO 9001 standardisation approach are presented. Six major occupational health requirements to high-quality management practices are identified pertaining to communication processes, organisational justice, role clarity, decision making, social influence processes and management support. It is concluded that the quality of management practices may be improved by developing a quality management system of management practices that ensures not only conformity to product but also to occupational safety and health requirements. Further research may evaluate the practicability of the proposed approach. PMID:26860787

  10. Monitoring underground water quality based on high-density resistivity method

    NASA Astrophysics Data System (ADS)

    Xu, Yanyan

    2015-12-01

    Underground water is different from surface water. Once contaminated, underground water is difficult to recover, so it is necessary to give priority to the prevention of the quality of underground water. High-density resistivity method is very important in the environmental engineering geophysical prospecting and it is widely used in mineral resources as well as monitoring the underground-water quality. In the experiment, multi-tools joint inversion is applied to build the model in order to increase the accuracy. In contrast with the pollution-free water model which is owned by the RES2DMOD, the inversion result of underground water quality with the high density resistivity method is useful to monitor the underground water quality, showing that different degree of water pollution depends on the position of abnormal and there is a more significant abnormal value in the vertical direction of the deep abnormal than that of the shallow abnormal, and high and low resistance pollution depends on the different value and forms of abnormal resistance. In conclusion, monitoring the underground water quality by the high density resistivity method is efficient. In the future research, it is necessary to accomplish more precise inversion models combining with field measurements to find out the optimal solution to monitor underwater quality.

  11. Isolation of high quality RNA from pistachio (Pistacia vera L.) and other woody plants high in secondary metabolites.

    PubMed

    Moazzam Jazi, Maryam; Rajaei, Saideh; Seyedi, Seyed Mahdi

    2015-10-01

    The quality and quantity of RNA are critical for successful downstream transcriptome-based studies such as microarrays and RNA sequencing (RNA-Seq). RNA isolation from woody plants, such as Pistacia vera, with very high amounts of polyphenols and polysaccharides is an enormous challenge. Here, we describe a highly efficient protocol that overcomes the limitations posed by poor quality and low yield of isolated RNA from pistachio and various recalcitrant woody plants. The key factors that resulted in a yield of 150 μg of high quality RNA per 200 mg of plant tissue include the elimination of phenol from the extraction buffer, raising the concentration of β-mercaptoethanol, long time incubation at 65 °C, and nucleic acid precipitation with optimized volume of NaCl and isopropyl alcohol. Also, the A260/A280 and A260/A230 of extracted RNA were about 1.9-2.1and 2.2-2.3, respectively, revealing the high purity. Since the isolated RNA passed highly stringent quality control standards for sensitive reactions, including RNA sequencing and real-time PCR, it can be considered as a reliable and cost-effective method for RNA extraction from woody plants.

  12. Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

    PubMed Central

    Sievers, Fabian; Wilm, Andreas; Dineen, David; Gibson, Toby J; Karplus, Kevin; Li, Weizhong; Lopez, Rodrigo; McWilliam, Hamish; Remmert, Michael; Söding, Johannes; Thompson, Julie D; Higgins, Desmond G

    2011-01-01

    Multiple sequence alignments are fundamental to many sequence analysis methods. Most alignments are computed using the progressive alignment heuristic. These methods are starting to become a bottleneck in some analysis pipelines when faced with data sets of the size of many thousands of sequences. Some methods allow computation of larger data sets while sacrificing quality, and others produce high-quality alignments, but scale badly with the number of sequences. In this paper, we describe a new program called Clustal Omega, which can align virtually any number of protein sequences quickly and that delivers accurate alignments. The accuracy of the package on smaller test cases is similar to that of the high-quality aligners. On larger data sets, Clustal Omega outperforms other packages in terms of execution time and quality. Clustal Omega also has powerful features for adding sequences to and exploiting information in existing alignments, making use of the vast amount of precomputed information in public databases like Pfam. PMID:21988835

  13. Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega.

    PubMed

    Sievers, Fabian; Wilm, Andreas; Dineen, David; Gibson, Toby J; Karplus, Kevin; Li, Weizhong; Lopez, Rodrigo; McWilliam, Hamish; Remmert, Michael; Söding, Johannes; Thompson, Julie D; Higgins, Desmond G

    2011-10-11

    Multiple sequence alignments are fundamental to many sequence analysis methods. Most alignments are computed using the progressive alignment heuristic. These methods are starting to become a bottleneck in some analysis pipelines when faced with data sets of the size of many thousands of sequences. Some methods allow computation of larger data sets while sacrificing quality, and others produce high-quality alignments, but scale badly with the number of sequences. In this paper, we describe a new program called Clustal Omega, which can align virtually any number of protein sequences quickly and that delivers accurate alignments. The accuracy of the package on smaller test cases is similar to that of the high-quality aligners. On larger data sets, Clustal Omega outperforms other packages in terms of execution time and quality. Clustal Omega also has powerful features for adding sequences to and exploiting information in existing alignments, making use of the vast amount of precomputed information in public databases like Pfam.

  14. High-quality colloidal photonic crystals obtained by optimizing growth parameters in a vertical deposition technique

    NASA Astrophysics Data System (ADS)

    Kuai, Su-Lan; Hu, Xing-Fang; Haché, Alain; Truong, Vo-Van

    2004-06-01

    High-quality polystyrene colloidal crystals were fabricated from aqueous solutions with a vertical deposition technique. The role of sphere size, volume fraction, relative humidity (RH), evaporation temperature and the final drying conditions on the film quality were investigated. We found that all those parameters must be taken into account in order to achieve highest quality for a given particle size. With particles of 300 nm in diameter, the optimal conditions were found to be a 0.1-0.2% volume fraction, an RH between 80% and 90%, an evaporation temperature near 60°C and a quasi-equilibrium drying process.

  15. Perioperative morbidity and mortality after noncardiac surgery in young adults with congenital or early acquired heart disease: a retrospective cohort analysis of the National Surgical Quality Improvement Program database.

    PubMed

    Maxwell, Bryan G; Wong, Jim K; Lobato, Robert L

    2014-04-01

    An increasing number of patients with congenital heart disease survive to adulthood. Expert opinion suggests that noncardiac surgery is a high-risk event, but few data describe perioperative outcomes in this population. Using the National Surgical Quality Improvement Program database, we identified a cohort of patients aged 18 to 39 years with prior heart surgery who underwent noncardiac surgery between 2005 and 2010. A comparison cohort with no prior cardiovascular surgery was matched on age, sex, race/ethnicity, operation year, American Society of Anesthesiologists physical status, and Current Procedural Terminology code. A study cohort consisting of 1191 patients was compared with a cohort of 5127 patients. Baseline dyspnea, inpatient status at the time of surgery, and a prior operation within 30 days were more common in the study cohort. Postoperative outcomes were less favorable in the study cohort. Observed rates of death, perioperative cardiac arrest, myocardial infarction, stroke, respiratory complications, renal failure, sepsis, venous thromboembolism, perioperative transfusion, and reoperation were significantly higher in the study cohort (P < 0.01 for all). Mean postoperative length of stay was greater in the study cohort (5.8 vs 3.6 days, P < 0.01). Compared with a matched control cohort, young adult patients with a history of prior cardiac surgery experienced significantly greater perioperative morbidity and mortality after noncardiac surgery. A history of prior cardiac surgery represents a marker of substantial perioperative risk in this young population that is not accounted for by the matched variables. These results suggest that adult patients with congenital heart disease are at risk for adverse outcomes and support the need for further registry-based investigations.

  16. Framework for High-Quality English Language Proficiency Standards and Assessments

    ERIC Educational Resources Information Center

    Assessment and Accountability Comprehensive Center, 2009

    2009-01-01

    The "Framework for High-Quality English Language Proficiency Standards and Assessments" (Framework) was conceived as a critical tool in states' efforts to ensure that their English learner (EL) students achieve English language proficiency (ELP) and, also, achieve at high levels academically. Building on the best knowledge from relevant research…

  17. Effects of High School Students' Perceptions of School Life Quality on Their Academic Motivation Levels

    ERIC Educational Resources Information Center

    Akin Kösterelioglu, Meltem; Kösterelioglu, Ilker

    2015-01-01

    This study aims to identify the effects of high school students' perceptions of school life quality on their academic motivation levels. The study was conducted on a sample of high school students (n = 2371) in Amasya Province in the fall semester of 2013-2014 academic year. Study sample was selected with the help of cluster sampling method. Data…

  18. High-Quality Draft Genome Sequence of Candida apicola NRRL Y-50540.

    PubMed

    Vega-Alvarado, Leticia; Gómez-Angulo, Jorge; Escalante-García, Zazil; Grande, Ricardo; Gschaedler-Mathis, Anne; Amaya-Delgado, Lorena; Sanchez-Flores, Alejandro; Arrizon, Javier

    2015-06-11

    Candida apicola, a highly osmotolerant ascomycetes yeast, produces sophorolipids (biosurfactants), membrane fatty acids, and enzymes of biotechnological interest. The genome obtained has a high-quality draft for this species and can be used as a reference to perform further analyses, such as differential gene expression in yeast from Candida genera.

  19. High-Quality Draft Genome Sequence of Candida apicola NRRL Y-50540

    PubMed Central

    Vega-Alvarado, Leticia; Gómez-Angulo, Jorge; Escalante-García, Zazil; Grande, Ricardo; Gschaedler-Mathis, Anne; Amaya-Delgado, Lorena

    2015-01-01

    Candida apicola, a highly osmotolerant ascomycetes yeast, produces sophorolipids (biosurfactants), membrane fatty acids, and enzymes of biotechnological interest. The genome obtained has a high-quality draft for this species and can be used as a reference to perform further analyses, such as differential gene expression in yeast from Candida genera. PMID:26067948

  20. Students' College Preparation Level Based on Quality Factors of the High School Attended

    ERIC Educational Resources Information Center

    Richmond, Lori M.

    2011-01-01

    The present qualitative study examined the views and perspectives of five Executive Directors of Admissions of Midwestern colleges and universities to seek data on high school students' college preparation level based on the quality factors of the high school they attended. Interviews were conducted using multiple open-ended questions on various…

  1. Teaching Surgical Procedures with Movies: Tips for High-quality Video Clips

    PubMed Central

    Jacquemart, Mathieu; Bouletreau, Pierre; Breton, Pierre; Mojallal, Ali

    2016-01-01

    Summary: Video must now be considered as a precious tool for learning surgery. However, the medium does present production challenges, and currently, quality movies are not always accessible. We developed a series of 7 surgical videos and made them available on a publicly accessible internet website. Our videos have been viewed by thousands of people worldwide. High-quality educational movies must respect strategic and technical points to be reliable. PMID:27757342

  2. Modern methods for the quality management of high-rate melt solidification

    NASA Astrophysics Data System (ADS)

    Vasiliev, V. A.; Odinokov, S. A.; Serov, M. M.

    2016-12-01

    The quality management of high-rate melt solidification needs combined solution obtained by methods and approaches adapted to a certain situation. Technological audit is recommended to estimate the possibilities of the process. Statistical methods are proposed with the choice of key parameters. Numerical methods, which can be used to perform simulation under multifactor technological conditions, and an increase in the quality of decisions are of particular importance.

  3. High-resolution remote sensing of water quality in the San Francisco Bay-Delta Estuary

    USGS Publications Warehouse

    Fichot, Cédric G.; Downing, Bryan D.; Bergamaschi, Brian; Windham-Myers, Lisamarie; Marvin-DiPasquale, Mark C.; Thompson, David R.; Gierach, Michelle M.

    2015-01-01

    The San Francisco Bay–Delta Estuary watershed is a major source of freshwater for California and a profoundly human-impacted environment. The water quality monitoring that is critical to the management of this important water resource and ecosystem relies primarily on a system of fixed water-quality monitoring stations, but the limited spatial coverage often hinders understanding. Here, we show how the latest technology in visible/near-infrared imaging spectroscopy can facilitate water quality monitoring in this highly dynamic and heterogeneous system by enabling simultaneous depictions of several water quality indicators at very high spatial resolution. The airborne portable remote imaging spectrometer (PRISM) was used to derive high-spatial-resolution (2.6 × 2.6 m) distributions of turbidity, and dissolved organic carbon (DOC) and chlorophyll-a concentrations in a wetland-influenced region of this estuary. A filter-passing methylmercury vs DOC relationship was also developed using in situ samples and enabled the high-spatial-resolution depiction of surface methylmercury concentrations in this area. The results illustrate how high-resolution imaging spectroscopy can inform management and policy development in important inland and estuarine water bodies by facilitating the detection of point- and nonpoint-source pollution, and by providing data to help assess the complex impacts of wetland restoration and climate change on water quality and ecosystem productivity.

  4. Performance analysis of high quality parallel preconditioners applied to 3D finite element structural analysis

    SciTech Connect

    Kolotilina, L.; Nikishin, A.; Yeremin, A.

    1994-12-31

    The solution of large systems of linear equations is a crucial bottleneck when performing 3D finite element analysis of structures. Also, in many cases the reliability and robustness of iterative solution strategies, and their efficiency when exploiting hardware resources, fully determine the scope of industrial applications which can be solved on a particular computer platform. This is especially true for modern vector/parallel supercomputers with large vector length and for modern massively parallel supercomputers. Preconditioned iterative methods have been successfully applied to industrial class finite element analysis of structures. The construction and application of high quality preconditioners constitutes a high percentage of the total solution time. Parallel implementation of high quality preconditioners on such architectures is a formidable challenge. Two common types of existing preconditioners are the implicit preconditioners and the explicit preconditioners. The implicit preconditioners (e.g. incomplete factorizations of several types) are generally high quality but require solution of lower and upper triangular systems of equations per iteration which are difficult to parallelize without deteriorating the convergence rate. The explicit type of preconditionings (e.g. polynomial preconditioners or Jacobi-like preconditioners) require sparse matrix-vector multiplications and can be parallelized but their preconditioning qualities are less than desirable. The authors present results of numerical experiments with Factorized Sparse Approximate Inverses (FSAI) for symmetric positive definite linear systems. These are high quality preconditioners that possess a large resource of parallelism by construction without increasing the serial complexity.

  5. Evaluation of High-Speed Civil Transport Handling Qualities Criteria with Supersonic Flight Data

    NASA Technical Reports Server (NTRS)

    Cox, Timothy H.; Jackson, Dante W.

    1997-01-01

    Most flying qualities criteria have been developed from data in the subsonic flight regime. Unique characteristics of supersonic flight raise questions about whether these criteria successfully extend into the supersonic flight regime. Approximately 25 years ago NASA Dryden Flight Research Center addressed this issue with handling qualities evaluations of the XB-70 and YF-12. Good correlations between some of the classical handling qualities parameters, such as the control anticipation parameter as a function of damping, were discovered. More criteria have been developed since these studies. Some of these more recent criteria are being used in designing the High-Speed Civil Transport (HSCT). A second research study recently addressed this issue through flying qualities evaluations of the SR-71 at Mach 3. The research goal was to extend the high-speed flying qualities experience of large airplanes and to evaluate more recent MIL-STD-1797 criteria against pilot comments and ratings. Emphasis was placed on evaluating the criteria used for designing the HSCT. XB-70 and YF-12 data from the previous research supplemented the SR-71 data. The results indicate that the criteria used in the HSCT design are conservative and should provide good flying qualities for typical high-speed maneuvering. Additional results show correlation between the ratings and comments and criteria for gradual maneuvering with precision control. Correlation is shown between ratings and comments and an extension of the Neal/Smith criterion using normal acceleration instead of pitch rate.

  6. Isolation of high-quality total RNA from leaves of Myrciaria dubia "CAMU CAMU".

    PubMed

    Gómez, Juan Carlos Castro; Reátegui, Alina Del Carmen Egoavil; Flores, Julián Torres; Saavedra, Roberson Ramírez; Ruiz, Marianela Cobos; Correa, Sixto Alfredo Imán

    2013-01-01

    Myrciaria dubia is a main source of vitamin C for people in the Amazon region. Molecular studies of M. dubia require high-quality total RNA from different tissues. So far, no protocols have been reported for total RNA isolation from leaves of this species. The objective of this research was to develop protocols for extracting high-quality total RNA from leaves of M. dubia. Total RNA was purified following two modified protocols developed for leaves of other species (by Zeng and Yang, and by Reid et al.) and one modified protocol developed for fruits of the studied species (by Silva). Quantity and quality of purified total RNA were assessed by spectrophotometric and electrophoretic analysis. Additionally, quality of total RNA was evaluated with reverse-transcription polymerase chain reaction (RT-PCR). With these three modified protocols we were able to isolate high-quality RNA (A260nm/A280nm >1.9 and A260nm/A230nm >2.0). Highest yield was produced with the Zeng and Yang modified protocol (384±46µg ARN/g fresh weight). Furthermore, electrophoretic analysis showed the integrity of isolated RNA and the absence of DNA. Another proof of the high quality of our purified RNA was the successful cDNA synthesis and amplification of a segment of the M. dubia actin 1 gene. We report three modified protocols for isolation total RNA from leaves of M. dubia. The modified protocols are easy, rapid, low in cost, and effective for high-quality and quantity total RNA isolation suitable for cDNA synthesis and polymerase chain reaction.

  7. Examining Relational Engagement across the Transition to High Schools in Three US High Schools Reformed to Improve Relationship Quality

    ERIC Educational Resources Information Center

    Davis, Heather A.; Chang, Mei-Lin; Andrzejewski, Carey E.; Poirier, Ryan R.

    2014-01-01

    The purpose of this study was to examine changes in students' relational engagement across the transition to high school in three schools reformed to improve the quality of student-teacher relationships. In order to analyze this data we employed latent growth curve (LGC) modeling techniques (n = 637). We ran three LGC models on three…

  8. Combined microfluidization and ultrasonication: a synergistic protocol for high-efficient processing of SWCNT dispersions with high quality

    NASA Astrophysics Data System (ADS)

    Luo, Sida; Liu, Tao; Wang, Yong; Li, Liuhe; Wang, Guantao; Luo, Yun

    2016-08-01

    High-efficient and large-scale production of high-quality CNT dispersions is necessary for meeting the future needs to develop various CNT-based electronic devices. Herein, we have designed novel processing protocols by combining conventional ultrasonication process with a new microfluidization technique to produce high-quality SWCNT dispersions with improved processing efficiency. To judge the quality of SWCNT dispersions, one critical factor is the degree of exfoliation, which could be quantified by both geometrical dimension of the exfoliated nanotubes and percentage of individual tubes in a given dispersion. In this paper, the synergistic effect of the combined protocols was systematically investigated through evaluating SWCNT dispersions with newly developed characterization techniques, namely preparative ultracentrifuge method (PUM) and simultaneous Raman scattering and photoluminescence spectroscopy (SRSPL). The results of both techniques draw similar conclusions that as compared with either of the processes operated separately, a low-pass microfluidization followed by a reasonable duration of ultrasonication could substantially improve the processing efficiency to produce high-quality SWCNT dispersions with averaged particle length and diameter as small as 600 and 2 nm, respectively.

  9. A novel MOCVD reactor for growth of high-quality GaN-related LED layers

    NASA Astrophysics Data System (ADS)

    Hu, Shaolin; Liu, Sheng; Zhang, Zhi; Yan, Han; Gan, Zhiyin; Fang, Haisheng

    2015-04-01

    Gallium nitride (GaN), a direct bandgap semiconductor widely used in bright light-emitting diodes (LEDs), is mostly grown by metal-organic chemical vapor deposition (MOCVD) method. A good reactor design is critical for the production of high-quality GaN thin films. In this paper, we presented a novel buffered distributed spray (BDS) MOCVD reactor with vertical gas sprayers and horizontal gas inlets. Experiments based on a 36×2″ BDS reactor were conducted to examine influence of the process parameters, such as the operating pressure and the gas flow rate, on the growth efficiency and on the layer thickness uniformity. Transmission electron microscopy (TEM) and photoluminescence (PL) are further conducted to evaluate quality of the epitaxial layers and to check performance of the reactor. Results show that the proposed novel reactor is of high performance in growing high-quality thin films, including InGaN/GaN multiquantum wells (MQWs) structures.

  10. Universal and rapid salt-extraction of high quality genomic DNA for PCR-based techniques.

    PubMed

    Aljanabi, S M; Martinez, I

    1997-11-15

    A very simple, fast, universally applicable and reproducible method to extract high quality megabase genomic DNA from different organisms is described. We applied the same method to extract high quality complex genomic DNA from different tissues (wheat, barley, potato, beans, pear and almond leaves as well as fungi, insects and shrimps' fresh tissue) without any modification. The method does not require expensive and environmentally hazardous reagents and equipment. It can be performed even in low technology laboratories. The amount of tissue required by this method is approximately 50-100 mg. The quantity and the quality of the DNA extracted by this method is high enough to perform hundreds of PCR-based reactions and also to be used in other DNA manipulation techniques such as restriction digestion, Southern blot and cloning.

  11. Quality Evaluation of Potentilla fruticosa L. by High Performance Liquid Chromatography Fingerprinting Associated with Chemometric Methods

    PubMed Central

    Liu, Wei; Wang, Dongmei; Liu, Jianjun; Li, Dengwu; Yin, Dongxue

    2016-01-01

    The present study was performed to assess the quality of Potentilla fruticosa L. sampled from distinct regions of China using high performance liquid chromatography (HPLC) fingerprinting coupled with a suite of chemometric methods. For this quantitative analysis, the main active phytochemical compositions and the antioxidant activity in P. fruticosa were also investigated. Considering the high percentages and antioxidant activities of phytochemicals, P. fruticosa samples from Kangding, Sichuan were selected as the most valuable raw materials. Similarity analysis (SA) of HPLC fingerprints, hierarchical cluster analysis (HCA), principle component analysis (PCA), and discriminant analysis (DA) were further employed to provide accurate classification and quality estimates of P. fruticosa. Two principal components (PCs) were collected by PCA. PC1 separated samples from Kangding, Sichuan, capturing 57.64% of the variance, whereas PC2 contributed to further separation, capturing 18.97% of the variance. Two kinds of discriminant functions with a 100% discrimination ratio were constructed. The results strongly supported the conclusion that the eight samples from different regions were clustered into three major groups, corresponding with their morphological classification, for which HPLC analysis confirmed the considerable variation in phytochemical compositions and that P. fruticosa samples from Kangding, Sichuan were of high quality. The results of SA, HCA, PCA, and DA were in agreement and performed well for the quality assessment of P. fruticosa. Consequently, HPLC fingerprinting coupled with chemometric techniques provides a highly flexible and reliable method for the quality evaluation of traditional Chinese medicines. PMID:26890416

  12. Quality Evaluation of Potentilla fruticosa L. by High Performance Liquid Chromatography Fingerprinting Associated with Chemometric Methods.

    PubMed

    Liu, Wei; Wang, Dongmei; Liu, Jianjun; Li, Dengwu; Yin, Dongxue

    2016-01-01

    The present study was performed to assess the quality of Potentilla fruticosa L. sampled from distinct regions of China using high performance liquid chromatography (HPLC) fingerprinting coupled with a suite of chemometric methods. For this quantitative analysis, the main active phytochemical compositions and the antioxidant activity in P. fruticosa were also investigated. Considering the high percentages and antioxidant activities of phytochemicals, P. fruticosa samples from Kangding, Sichuan were selected as the most valuable raw materials. Similarity analysis (SA) of HPLC fingerprints, hierarchical cluster analysis (HCA), principle component analysis (PCA), and discriminant analysis (DA) were further employed to provide accurate classification and quality estimates of P. fruticosa. Two principal components (PCs) were collected by PCA. PC1 separated samples from Kangding, Sichuan, capturing 57.64% of the variance, whereas PC2 contributed to further separation, capturing 18.97% of the variance. Two kinds of discriminant functions with a 100% discrimination ratio were constructed. The results strongly supported the conclusion that the eight samples from different regions were clustered into three major groups, corresponding with their morphological classification, for which HPLC analysis confirmed the considerable variation in phytochemical compositions and that P. fruticosa samples from Kangding, Sichuan were of high quality. The results of SA, HCA, PCA, and DA were in agreement and performed well for the quality assessment of P. fruticosa. Consequently, HPLC fingerprinting coupled with chemometric techniques provides a highly flexible and reliable method for the quality evaluation of traditional Chinese medicines.

  13. Classroom risks and resources: Teacher burnout, classroom quality and children's adjustment in high needs elementary schools.

    PubMed

    Hoglund, Wendy L G; Klingle, Kirsten E; Hosan, Naheed E

    2015-10-01

    The current paper presents two related sets of findings on the classroom context in high needs elementary schools. First, we investigated change over one school term in teacher burnout (emotional exhaustion, depersonalization, personal accomplishment) and classroom quality (emotional and instructional support, organization) and assessed the degree to which burnout and classroom quality co-varied over the term with each other and with aggregate externalizing behaviors (average child externalizing behaviors in the classroom). These analyses describe the classroom context in which the children are nested. Second, we examined change over one school term in children's social adjustment (relationship quality with teachers and friends) and academic adjustment (school engagement, literacy skills) and assessed how adjustment co-varied over time with child externalizing behaviors and was predicted by teacher burnout, classroom quality and aggregate externalizing behaviors. These models were tested with a sample of low-income, ethnically diverse children in kindergarten to grade 3 and their teachers. The children and teachers were assessed three times over one school term. Personal accomplishment co-varied positively with overall classroom quality. Reciprocally, classroom organization co-varied positively with overall teacher burnout. Aggregate externalizing behaviors co-varied positively with depersonalization and negatively with personal accomplishment and overall classroom quality, including emotional support and organization. In turn, teacher burnout interacted with aggregate externalizing behaviors to predict change in child social and academic adjustment. Alternatively, classroom quality interacted with aggregate and child externalizing behaviors to predict change in child social and academic adjustment.

  14. High Quality Binary Protein Interaction Map of the Yeast Interactome Network

    PubMed Central

    Yu, Haiyuan; Braun, Pascal; Yildirim, Muhammed A.; Lemmens, Irma; Venkatesan, Kavitha; Sahalie, Julie; Hirozane-Kishikawa, Tomoko; Gebreab, Fana; Li, Na; Simonis, Nicolas; Hao, Tong; Rual, Jean-Franćois; Dricot, Amélie; Vazquez, Alexei; Murray, Ryan R.; Simon, Christophe; Tardivo, Leah; Tam, Stanley; Svrzikapa, Nenad; Fan, Changyu; de Smet, Anne-Sophie; Motyl, Adriana; Hudson, Michael E.; Park, Juyong; Xin, Xiaofeng; Cusick, Michael E.; Moore, Troy; Boone, Charlie; Snyder, Michael; Roth, Frederick P.; Barabási, Albert-László; Tavernier, Jan; Hill, David E.; Vidal, Marc

    2009-01-01

    Current yeast interactome network maps contain several hundred molecular complexes with limited and somewhat controversial representation of direct binary interactions. We carried out a comparative quality assessment of current yeast interactome datasets, demonstrating that high-throughput yeast two-hybrid (Y2H) provides high-quality binary interaction information. As a large fraction of the yeast binary interactome remains to be mapped, we developed an empirically-controlled mapping framework to produce a “second-generation” high-quality high-throughput Y2H dataset covering ~20% of all yeast binary interactions. Both Y2H and affinity-purification followed by mass spectrometry (AP/MS) data are of equally high quality but of a fundamentally different and complementary nature resulting in networks with different topological and biological properties. Compared to co-complex interactome models, this binary map is enriched for transient signaling interactions and inter-complex connections with a highly significant clustering between essential proteins. Rather than correlating with essentiality, protein connectivity correlates with genetic pleiotropy. PMID:18719252

  15. Different Polar Metabolites and Protein Profiles between High- and Low-Quality Japanese Ginjo Sake

    PubMed Central

    Takahashi, Kei; Kohno, Hiromi

    2016-01-01

    Japanese ginjo sake is a premium refined sake characterized by a pleasant fruity apple-like flavor and a sophisticated taste. Because of technical difficulties inherent in brewing ginjo sake, off-flavors sometimes occur. However, the metabolites responsible for off-flavors as well as those present or absent in higher quality ginjo sake remain uncertain. Here, the relationship between 202 polar chemical compounds in sake identified using capillary electrophoresis coupled with time-of-flight mass spectrometry and its organoleptic properties, such as quality and off-flavor, was examined. First, we found that some off-flavored sakes contained higher total amounts of metabolites than other sake samples. The results also identified that levels of 2-oxoglutaric acid and fumaric acid, metabolites in the tricarboxylic acid cycle, were highly but oppositely correlated with ginjo sake quality. Similarly, pyridoxine and pyridoxamine, co-enzymes for amino transferase, were also highly but oppositely correlated with ginjo sake quality. Additionally, pyruvic acid levels were associated with good quality as well. Compounds involved in the methionine salvage cycle, oxidative glutathione derivatives, and amino acid catabolites were correlated with low quality. Among off-flavors, an inharmonious bitter taste appeared attributable to polyamines. Furthermore, protein analysis displayed that a diversity of protein components and yeast protein (triosephosphate isomerase, TPI) leakage was linked to the overall metabolite intensity in ginjo sake. This research provides insight into the relationship between sake components and organoleptic properties. PMID:26939054

  16. Comparison of High and Low Density Airborne LIDAR Data for Forest Road Quality Assessment

    NASA Astrophysics Data System (ADS)

    Kiss, K.; Malinen, J.; Tokola, T.

    2016-06-01

    Good quality forest roads are important for forest management. Airborne laser scanning data can help create automatized road quality detection, thus avoiding field visits. Two different pulse density datasets have been used to assess road quality: high-density airborne laser scanning data from Kiihtelysvaara and low-density data from Tuusniemi, Finland. The field inventory mainly focused on the surface wear condition, structural condition, flatness, road side vegetation and drying of the road. Observations were divided into poor, satisfactory and good categories based on the current Finnish quality standards used for forest roads. Digital Elevation Models were derived from the laser point cloud, and indices were calculated to determine road quality. The calculated indices assessed the topographic differences on the road surface and road sides. The topographic position index works well in flat terrain only, while the standardized elevation index described the road surface better if the differences are bigger. Both indices require at least a 1 metre resolution. High-density data is necessary for analysis of the road surface, and the indices relate mostly to the surface wear and flatness. The classification was more precise (31-92%) than on low-density data (25-40%). However, ditch detection and classification can be carried out using the sparse dataset as well (with a success rate of 69%). The use of airborne laser scanning data can provide quality information on forest roads.

  17. Acquired ciliary circumscribed grey hair (ACCG).

    PubMed

    Romero, A G; Calatayud, J C

    2001-12-01

    Grey-haired areas usually occur due to aging or inheritance. A case is described of abrupt occurrence of a focal circumscribed grey-hair in the eyebrow region (a single hair) in a 27-year-old woman. The phenomenon was named acquired ciliary circumscribed grey-hair (ACCG). Qualitative and semiquantitative findings were obtained by microanalytical studies. In addition to morphological differences from control hair, the ACCG hair showed a high percentage of sulfur (99.8%) and absence of oligoelements.

  18. Optimization of femtosecond Yb-doped fiber amplifiers for high-quality pulse compression.

    PubMed

    Chen, Hung-Wen; Lim, JinKang; Huang, Shu-Wei; Schimpf, Damian N; Kärtner, Franz X; Chang, Guoqing

    2012-12-17

    We both theoretically and experimentally investigate the optimization of femtosecond Yb-doped fiber amplifiers (YDFAs) to achieve high-quality, high-power, compressed pulses. Ultrashort pulses amplified inside YDFAs are modeled by the generalized nonlinear Schrödinger equation coupled to the steady-state propagation-rate equations. We use this model to study the dependence of compressed-pulse quality on the YDFA parameters, such as the gain fiber's doping concentration and length, and input pulse pre-chirp, duration, and power. The modeling results confirmed by experiments show that an optimum negative pre-chirp for the input pulse exists to achieve the best compression.

  19. Dynamic stability and handling qualities tests on a highly augmented, statically unstable airplane

    NASA Technical Reports Server (NTRS)

    Gera, Joseph; Bosworth, John T.

    1987-01-01

    Novel flight test and analysis techniques in the flight dynamics and handling qualities area are described. These techniques were utilized at NASA Ames-Dryden during the initial flight envelope clearance of the X-29A aircraft. It is shown that the open-loop frequency response of an aircraft with highly relaxed static stability can be successfully computed on the ground from telemetry data. Postflight closed-loop frequency response data were obtained from pilot-generated frequency sweeps and it is found that the current handling quality requirements for high-maneuverability aircraft are generally applicable to the X-29A.

  20. [Important problems of high quality drinking water supply, and the ways of their solution].

    PubMed

    Rakhmanin, Iu A; Mikhaĭlova, R I; Kir'ianova, L F; Sevost'ianova, E M; Ryzhova, I N; Skovronskiĭ, A Iu

    2006-01-01

    The article covers the results of experimental and natural studies concerning important directions in the field of drinking water supply, including such aspects as: research into and classification of the barrier role of conventional and prospective technologies of water preparation in terms of chemical and biological pollution; revision of the standards of drinking water quality control in accordance with international documents; the main aspects of revision of the general conception of high quality water supply, within which hygienic requirements concerning the quality of prepackaged waters and the ranking of different techniques of water preparation used in water purification units, have been developed for the first time. The authors present the results of experimental studies on the patterns of disinfection, purification, and conditioning of drinking water quality using energetic- and-information technologies of water preparation.

  1. High-quality, affordable healthcare in the United States--an achievable goal.

    PubMed

    Barton, Glen A

    2004-01-01

    We have evidence that quality and efficiency work together for better healthcare processes for patients while providing cost savings for employers. The complex processes and frequent disconnects among providers who care for the same patients are obviously an area of opportunity for improvement. By standardizing processes for care, we can begin to effectively measure quality and efficiency throughout the value chain. When we work as a team, focusing on quality and measurement, we can look to a future when the best possible care is efficiently and effectively delivered to patients. The future will also be brighter for employers dedicated to providing high-quality, competitive benefits for their valued employees and retirees while maintaining profitability.

  2. Exploiting crowdsourced observations: High-resolution mapping of real-time urban air quality throughout Europe

    NASA Astrophysics Data System (ADS)

    Schneider, Philipp; Castell, Nuria; Vallejo, Islen; van den Bossche, Joris; Lahoz, William; Bartonova, Alena

    2016-04-01

    With the technology of air quality sensors improving rapidly in recent years and with an increasing number of initiatives for collecting air quality information being established worldwide, there is a rapidly increasing amount of information on air quality. Such datasets can provide unprecedented spatial detail and thus exhibit a significant potential for allowing to create observation-based high-resolution maps of air quality in the urban environment. However, most datasets of observations made within a citizen science or crowdsourcing framework tend to have highly variable characteristics in terms of quantity, accuracy, measured parameters, and representativeness, and many more. It is therefore currently unknown how to best exploit this information for mapping purposes. In order to address this challenge we present a novel approach for combining crowdsourced observations of urban air quality with model information, allowing us to produce near-real-time, high-resolution maps of air quality in the urban environment. The approach is based on data fusion techniques, which allow for combining observations with model data in a mathematically objective way and therefore provide a means of adding value to both the observations and the model. The observations are improved by filling spatio-temporal gaps in the data and the model is improved by constraining it with observations. The model further provides detailed spatial patterns in areas where no observations are available. As such, data fusion of observations from high-density low-cost sensor networks together with air quality models can contribute to significantly improving urban-scale air quality mapping. The system has been implemented to run in an automated fashion in near real-time (once every hour) for several cities in Europe. Evaluation of the methodology is being carried out using the leave-one-out cross validation technique and simulated datasets. We present case studies demonstrating the methodology for

  3. 160 W high-power, high-efficiency, near-diffraction-limited beam quality all-fiber picosecond pulse laser

    NASA Astrophysics Data System (ADS)

    Sun, Chang; Ge, Tingwu; An, Na; Cao, Kang; Wang, Zhiyong

    2016-10-01

    We experimentally demonstrate a high-power, high-efficiency, near-diffraction-limited beam quality all-fiber picosecond pulse laser, which consists of a passively mode-locked seed laser and three-stage master power amplifiers. A repetition frequency multiplier and a high Yb-doped gain fiber with shorter length are utilized in the laser system to suppress the nonlinear effects and reduce the pulse broadening caused by dispersion. Moreover, the homemade light mode controllers based on a coiling and tapering fiber technique and the active fiber of the amplifier with a relatively small mode area are adopted to improve the beam quality. In addition, by experimentally adjusting the active fiber length, the optical conversion efficiency of the overall laser system can be optimized. Eventually, a 160 W high-power, high-efficiency, near-diffraction-limited picosecond pulse fiber laser is obtained, with the beam quality factor M2 at 1.12 and an optical conversion efficiency of the system of 75%.

  4. Oral manifestations of human immunodeficiency virus/acquired immunodeficiency syndrome and their correlation to cluster of differentiation lymphocyte count in population of North-East India in highly active antiretroviral therapy era

    PubMed Central

    Nayak, Sarat Kumar; Das, Bijay Kumar; Das, Surya Narayan; Mohapatra, Namita; Nayak, Suryakanti; Bhuyan, Lipsa

    2016-01-01

    Background: The human immunodeficiency virus (HIV) infection which manifests as acquired immunodeficiency syndrome (AIDS) is a disease involving the defects of the T-lymphocyte arm of the immune system. Certain laboratory parameters such as the cluster of differentiation (CD4) count and clinical parameters have long been used as markers of disease progression. In industrialized countries, many studies show a highly correlation between the incidence of oral lesions and immunosuppression and hence, can be used as a marker of immunosuppression. This might not be applicable to a developing country like India. In this study, efforts have been made to supplement the present knowledge on various aspects of oral manifestations in HIV patients in the Indian subcontinent. Aims: To correlate the oral manifestations in HIV/AIDS patients to the level of circulating CD4+ T-lymphocyte count and their effect in anti-retroviral therapy (ART). Subjects and Methods: A total of 104 HIV positive patients were examined for oral lesions. The CD4 count estimated on the same day by fluorescent activated cell sort count machine was then correlated with various oral lesions. Results: Oral manifestations appeared when CD4 count decreased below 500 cells/mm3. Moreover, oral lesions found at different stages showed very strong correlation to their respective CD4 count. Furthermore, there was considerable decline in the incidence of oral manifestations in patients undergoing highly active ART. Conclusions: Oral manifestations are highly predictive markers of severe immune deterioration and disease progression in HIV patients. PMID:27994425

  5. Musicality: instinct or acquired skill?

    PubMed

    Marcus, Gary F

    2012-10-01

    Is the human tendency toward musicality better thought of as the product of a specific, evolved instinct or an acquired skill? Developmental and evolutionary arguments are considered, along with issues of domain-specificity. The article also considers the question of why humans might be consistently and intensely drawn to music if musicality is not in fact the product of a specifically evolved instinct.

  6. Duplicated Information Acquired by Libraries.

    ERIC Educational Resources Information Center

    White, Carl M.

    The object of this study is to make a start toward determining the extent of duplicated information that is being acquired in spite of customary precautions to avoid it. Referring to a specific case, the percentages in Table II show the frequency of appearance in five other works of 19 items in Mitchell's "Encyclopedia of American Politics." While…

  7. Acquired aplastic anemia in children.

    PubMed

    Hartung, Helge D; Olson, Timothy S; Bessler, Monica

    2013-12-01

    This article provides a practice-based and concise review of the etiology, diagnosis, and management of acquired aplastic anemia in children. Bone marrow transplantation, immunosuppressive therapy, and supportive care are discussed in detail. The aim is to provide the clinician with a better understanding of the disease and to offer guidelines for the management of children with this uncommon yet serious disorder.

  8. Microstructural and Material Quality Effects on Rolling Contact Fatigue of Highly Elastic Intermetallic Ball Bearings

    NASA Technical Reports Server (NTRS)

    DellaCorte, Christopher; Howard, S. Adam; Thomas, Fransua; Stanford, Malcolm K.

    2016-01-01

    Rolling element bearings made from highly-elastic intermetallic materials (HIM)s, such as 60NiTi, are under development for applications that require superior corrosion and shock resistance. Compared to steel, intermetallics have been shown to have much lower rolling contact fatigue (RCF) stress capability in simplified 3-ball on rod (ASTM STP 771) fatigue tests. In the 3-ball tests, poor material quality and microstructural flaws negatively affect fatigue life but such relationships have not been established for full-scale 60NiTi bearings. In this paper, 3-ball-on-rod fatigue behavior of two quality grades of 60NiTi are compared to the fatigue life of full-scale 50mm bore ball bearings made from the same materials. 60NiTi RCF rods with material or microstructural flaws suffered from infant mortality failures at all tested stress levels while high quality 60NiTi rods exhibited no failures at lower stress levels. Similarly, tests of full-scale bearings made from flawed materials exhibited early surface fatigue and through crack type failures while bearings made from high quality material did not fail even in long-term tests. Though the full-scale bearing test data is yet preliminary, the results suggest that the simplified RCF test is a good qualitative predictor of bearing performance. These results provide guidance for materials development and to establish minimum quality levels required for successful bearing operation and life.

  9. Water-quality response to a high-elevation wildfire in the Colorado Front Range

    USGS Publications Warehouse

    Mast, M. Alisa; Murphy, Sheila F.; Clow, David W.; Penn, Colin A.; Sexstone, Graham A.

    2016-01-01

    Water quality of the Big Thompson River in the Front Range of Colorado was studied for 2 years following a high-elevation wildfire that started in October 2012 and burned 15% of the watershed. A combination of fixed-interval sampling and continuous water-quality monitors was used to examine the timing and magnitude of water-quality changes caused by the wildfire. Prefire water quality was well characterized because the site has been monitored at least monthly since the early 2000s. Major ions and nitrate showed the largest changes in concentrations; major ion increases were greatest in the first postfire snowmelt period, but nitrate increases were greatest in the second snowmelt period. The delay in nitrate release until the second snowmelt season likely reflected a combination of factors including fire timing, hydrologic regime, and rates of nitrogen transformations. Despite the small size of the fire, annual yields of dissolved constituents from the watershed increased 20–52% in the first 2 years following the fire. Turbidity data from the continuous sensor indicated high-intensity summer rain storms had a much greater effect on sediment transport compared to snowmelt. High-frequency sensor data also revealed that weekly sampling missed the concentration peak during snowmelt and short-duration spikes during rain events, underscoring the challenge of characterizing postfire water-quality response with fixed-interval sampling.

  10. Efficient isolation of high-quality RNA from lotus Nelumbo nucifera ssp nucifera tissues.

    PubMed

    Zhang, Y J; Hao, X Y; Liang, Z S; Ke, W D; Guo, H B

    2013-01-24

    Nelumbo nucifera is widely used as food, as an ornamental, in medicine, and as packing material; it is also reported to have anti-HIV effects and antioxidant capacity. We sought an improved method for extracting high-quality total RNA from different tissues of N. nucifera. Four methods for RNA extraction were assessed for their ability to recover high-quality RNA applicable for evaluation of polyphenol oxidase (PPO) gene expression profiles. The recovery and quality of the RNA obtained from five different tissues by the best CTAB-LiCl method were evaluated through UV light absorbance. Both A(260)/A(280) and A(260)/A(230) absorbance ratios were more than 2.0; the yield ranged from 59.87 to 163.75 μg/g fresh weight. The brightness of the 28S band was approximately twice that of 18S; the latter was also considered as high-quality RNA. The PPO gene fragment (606 bp) was successfully amplified by RT-PCR, demonstrating the integrity of the isolated RNA. The relative expression levels of the PPO gene based on RT-PCR in five tissues of lotus were: rhizome buds (2.66), young leaves (2.42), fresh cut rhizome (2.02), petals (1.80), and petiole (1.65), using housekeeping gene β-actin as an internal control. We concluded that the total RNA isolated by this protocol is of sufficient quality for molecular applications.

  11. Differences in Bone Quality between High versus Low Turnover Renal Osteodystrophy

    SciTech Connect

    Porter, Daniel S.; Pienkowski, David; Faugere, Marie-Claude; Malluche, Hartmut H.

    2012-01-01

    Abnormal bone turnover is common in chronic kidney disease (CKD), but its effects on bone quality remain unclear. This study sought to quantify the relationship between abnormal bone turnover and bone quality. Iliac crest bone biopsies were obtained from CKD-5 patients on dialysis with low (n=18) or high (n=17) turnover, and from volunteers (n=12) with normal turnover and normal kidney function. Histomorphometric methods were used to quantify the microstructural parameters; Fourier transform infrared spectroscopy and nanoindentation were used to quantify the material and mechanical properties in bone. Reduced mineral-to-matrix ratio, mineral crystal size, stiffness and hardness were observed in bone with high turnover compared to bone with normal or low turnover. Decreased cancellous bone volume and trabecular thickness were seen in bone with low turnover compared to bone with normal or high turnover. Bone quality, as defined by its microstructural, material, and mechanical properties, is related to bone turnover. These data suggest that turnover related alterations in bone quality may contribute to the known diminished mechanical competence of bone in CKD patients, albeit from different mechanisms for bone with high (material abnormality) vs. low (microstructural alteration) turnover. The present findings suggest that improved treatments for renal osteodystrophy should seek to avoid low or high bone turnover and aim for turnover rates as close to normal as possible.

  12. High-speed image acquisition technology in quality detection of workpiece surface

    NASA Astrophysics Data System (ADS)

    Wu, Kaihua; Jin, Zexuan; Wang, Wenjie; Chen, Nian

    2016-11-01

    High-speed image acquisition technology has a great significance to improve the effciency of the workpiece surface quality detection, image quality directly affects the final test results. Aiming at the high-speed image acquisition of workpiece surface quality online detection, a workpiece image high-speed online acquisition method was produced. A high-speed online image acquisition sequence was designed. The quantitative relationship between the positioning accuracy in the high speed online image acquisition, motion blur, exposure time and the speed of workpiece was analyzed. The effect between the vibration between transfer mechanism and workpiece was analyzed. Fast trigger was implemented by photoelectric sensor. The accurate positioning was implemented by using the high accuracy time delay module. The motion blur was controlled by reducing the exposure time. A high-speed image acquisition system was designed based on the high-speed image acquisition method. The positioning accuracy was less than 0.1 mm, and the motion blur was less than one pixel.

  13. Waves, Instabilities, and Rivulets in High Quality Microgap Two-Phase Flow

    NASA Astrophysics Data System (ADS)

    Bar-Cohen, A.; Holloway, C.

    2016-09-01

    Two-phase flow in sub-millimeter microgap channels offers highly potent thermal management capability and is the foundation for the emerging "embedded cooling" paradigm of electronic cooling. While the thermofluid characteristics and operational limits of such microcoolers are intimately tied to distinct forms of vapor-liquid aggregation in the microgap channel, insufficient attention has been paid to the formation of distinct wave patterns and instabilities on the thin liquid films associated with high-quality microgap channel flow. This paper focuses on the results of visualization and heat transfer studies of such two-phase flows, under both adiabatic and diabatic conditions, for FC-72 flowing in a 184 micron microgap channel at a mass flux of 230 kg/(m2.s). The study has revealed the existence of a post-annular, high-quality Rivulet flow regime, in which the liquid film breakdown and local wall dryout drives large surface anisothermalities and limits the heat transfer rate from the wall. As predicted by the prevailing flow regime models, annular flow is found to be the dominant flow regime for this microgap configuration.. For the adiabatic conditions, flow qualities ranged between 27% and 81%, and widely spaced, 3D waves, with a wavelength that decreases with increasing flow quality, were observed on the liquid-vapor interface. For the diabatic condition, the inlet flow quality was maintained at 36% and the exit flow quality varied between 47% and 97%. For exit qualities greater than 61%, the liquid film would periodically rupture into rivulet of varying width and length. The spacing, length, and width of the rivulets varied considerably, and can easily stretch well into dryout region. The axial variation of the wall heat transfer coefficient was found to reflect and confirm the expected axial propagation of the two- phase flow regimes and the onset of local dryout associated with the newly-defined Rivulet regime.

  14. Simulation of the wavefront distortion and beam quality for a high-power zigzag slab laser

    NASA Astrophysics Data System (ADS)

    Shin, Jae Sung; Cha, Yong-Ho; Cha, Byung Heon; Lee, Hyeon Cheor; Kim, Hyun Tae; Lee, Jung Hwan

    2016-12-01

    A simulation method of the beam quality for a high-power zigzag slab laser has been developed. This method can predict the wavefront distortion and beam quality for various optical arrangements and optimize the design effectively. A Nd:YAG zigzag slab laser amplifier was designed as an application. The optimized design shows a beam quality of 1.20 corresponding to the minimized wavefront distortion with a peak-to-valley of 0.568 μm and root mean square of 0.115 μm even under high-power operation with a total pump power of 14 kW. Although there are some effects other than the optical design error that incur wavefront distortions, this method can help to determine the first optical design of the zigzag slab laser without the need for many experimental studies.

  15. Three-dimensional dictionary-based deblocking for high-quality stereoscopic view generation

    NASA Astrophysics Data System (ADS)

    Jung, Cheolkon; Qi, Hongtao; Sun, Zengzeng; Jiao, Licheng

    2013-10-01

    Image quality and depth perception rates in three-dimensional television (3-D TV) are undesirably decreased by coding due to the loss of high-frequency components caused by a block-based discrete cosine transform transform. Representative coding artifacts are blocking artifacts that seriously degrade the picture quality and depth perception rates. We propose a new blocking artifact reduction method in 3-D TV using an overcomplete 3-D dictionary. We first generate the overcomplete 3-D dictionary from natural and depth images using the k-singular value decomposition algorithm. Then, we perform deblocking using the 3-D dictionary after estimating an error threshold of the objective function by the third-order polynomial fitting. Experimental results demonstrate that the proposed method can effectively reduce annoying blocking artifacts in compressed 3-D images, i.e., video-plus-depth, and generate high-quality 3-D stereoscopic views.

  16. Air Quality Standards for Particulate Matter (PM) at high altitude cities.

    PubMed

    Bravo Alvarez, H; Sosa Echeverria, R; Sanchez Alvarez, P; Krupa, S

    2013-02-01

    The Air Quality Standards for Particulate Matter (PM) at high altitude urban areas in different countries, must consider the pressure and temperature due to the effect that these parameters have on the breath volume. This paper shows the importance to correct Air Quality Standards for PM considering pressure and temperature at different altitudes. Specific factors were suggested to convert the information concerning PM, from local to standard conditions, and adjust the Air Quality Standards for different high altitudes cities. The correction factors ranged from: 1.03 for Santiago de Chile to 1.47 for El Alto Bolivia. Other cities in this study include: Mexico City, México; La Paz, Bolivia; Bogota, Cali and Medellin, Colombia; Quito, Ecuador and Cuzco, Peru. If these corrections are not considered, the atmospheric concentrations will be underestimated.

  17. Economic Evaluation of Interventions for Prevention of Hospital Acquired Infections: A Systematic Review

    PubMed Central

    Kwetkat, Anja

    2016-01-01

    Objective This systematic review sought to assess the costs and benefits of interventions preventing hospital-acquired infections and to evaluate methodological and reporting quality. Methods We systematically searched Medline via PubMed and the National Health Service Economic Evaluation Database from 2009 to 2014. We included quasi-experimental and randomized trails published in English or German evaluating the economic impact of interventions preventing the four most frequent hospital-acquired infections (urinary tract infections, surgical wound infections, pneumonia, and primary bloodstream infections). Characteristics and results of the included articles were extracted using a standardized data collection form. Study and reporting quality were evaluated using SIGN and CHEERS checklists. All costs were adjusted to 2013 US$. Savings-to-cost ratios and difference values with interquartile ranges (IQRs) per month were calculated, and the effects of study characteristics on the cost-benefit results were analyzed. Results Our search returned 2067 articles, of which 27 met the inclusion criteria. The median savings-to-cost ratio across all studies reporting both costs and savings values was US $7.0 (IQR 4.2–30.9), and the median net global saving was US $13,179 (IQR 5,106–65,850) per month. The studies’ reporting quality was low. Only 14 articles reported more than half of CHEERS items appropriately. Similarly, an assessment of methodological quality found that only four studies (14.8%) were considered high quality. Conclusions Prevention programs for hospital acquired infections have very positive cost-benefit ratios. Improved reporting quality in health economics publications is required. PMID:26731736

  18. History and challenges of national examination as a quality measurement for high school students in Indonesia

    NASA Astrophysics Data System (ADS)

    Rozamuri, Arif Murti; Suradi, Nur Riza Mohd

    2015-02-01

    Education in Indonesia has been established before the Indonesian state. Therefore, the history of Education in Indonesia is quite long. Education that has existed since ancient times, and then forwarded to the days of the Hindu and Buddhist religious influence, then the influence of Islamic religious era, the education in the colonial era until education in independence era. At Indonesia for senior high school students, the quality measured by national exam. The national examination has a long history and full of pros and cons in determining the quality of students. With different level social economic status, and teacher quality in each schools, the student quality would be assessed within a period of three years. The interesting part is whether the national examination, able to measure the quality of students?. Is the quality of students can only be measured through the national exam?. Then various fraud taint the education particularly in the implementation of national examination. This research would explain long history of national examination and various problems that occur in national examination.

  19. Taking a Measure of Impact: 2 Colorado Districts Calibrate the Effects of High Quality Professional Learning

    ERIC Educational Resources Information Center

    Jacobson, Linda

    2016-01-01

    Snapshots of two Colorado districts in the Redesign PD Community of Practice: Denver Public Schools' professional learning partners help subject-matter experts and others provide educators with a high-quality learning experience. In Jefferson County, Learning Forward's Standards for Professional Learning guide educators to make teacher…

  20. Conflicting Expertise and Uncertainty: Quality Assurance in High-Level Radioactive Waste Management.

    ERIC Educational Resources Information Center

    Fitzgerald, Michael R.; McCabe, Amy Snyder

    1991-01-01

    Dynamics of a large, expensive, and controversial surface and underground evaluation of a radioactive waste management program at the Yucca Mountain power plant are reviewed. The use of private contractors in the quality assurance study complicates the evaluation. This case study illustrates high stakes evaluation problems. (SLD)

  1. Infantile nystagmus syndrome: Broadening the high-foveation-quality field with contact lenses

    PubMed Central

    Taibbi, Giovanni; Wang, Zhong I; Dell’Osso, Louis F

    2008-01-01

    We investigated the effects of contact lenses in broadening and improving the high-foveation-quality field in a subject with infantile nystagmus syndrome (INS). A high-speed, digitized video system was used for the eye-movement recording. The subject was asked to fixate a far target at different horizontal gaze angles with contact lenses inserted. Data from the subject while fixating at far without refractive correction and at near (at a convergence angle of 60 PD), were used for comparison. The eXpanded Nystagmus Acuity Function (NAFX) was used to evaluate the foveation quality at each gaze angle. Contact lenses broadened the high-foveation-quality range of gaze angles in this subject. The broadening was comparable to that achieved during 60 PD of convergence although the NAFX values were lower. Contact lenses allowed the subject to see “more” (he had a wider range of high-foveation-quality gaze angles) and “better” (he had improved foveation at each gaze angle). Instead of being contraindicated by INS, contact lenses emerge as a potentially important therapeutic option. Contact lenses employ afferent feedback via the ophthalmic division of the V cranial nerve to damp INS slow phases over a broadened range of gaze angles. This supports the proprioceptive hypothesis of INS improvement. PMID:19668758

  2. Guiding Principles for Providing High-Quality Education in Juvenile Justice Secure Care Settings

    ERIC Educational Resources Information Center

    US Department of Education, 2014

    2014-01-01

    Providing high-quality education in juvenile justice secure care settings presents unique challenges for the administrators, teachers, and staff who are responsible for the education, rehabilitation, and welfare of youths committed to their care. The United States departments of Education (ED) and Justice (DOJ) recognize that while these…

  3. A Model for Developing High-Quality Online Courses: Integrating a Systems Approach with Learning Theory

    ERIC Educational Resources Information Center

    Puzziferro, Maria; Shelton, Kaye

    2008-01-01

    As the demand for online education continues to increase, institutions are faced with developing process models for efficient, high-quality online course development. This paper describes a systems, team-based, approach that centers on an online instructional design theory ("Active Mastery Learning") implemented at Colorado State…

  4. Effect of high hydrostatic pressure processing on the background microbial loads and quality of cantaloupe puree

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The objective of this study was to investigate and evaluate the effects of high hydrostatic pressure (HHP) applied to cantaloupe puree (CP) on microbial loads and product quality during storage for 10 days at 4 degrees C. Freshly prepared, double sealed and double bagged CP (ca. 5 g) was pressure tr...

  5. High angle of attack flying qualities criteria for longitudinal rate command systems

    NASA Technical Reports Server (NTRS)

    Wilson, David J.; Citurs, Kevin D.; Davidson, John B.

    1994-01-01

    This study was designed to investigate flying qualities requirements of alternate pitch command systems for fighter aircraft at high angle of attack. Flying qualities design guidelines have already been developed for angle of attack command systems at 30, 45, and 60 degrees angle of attack, so this research fills a similar need for rate command systems. Flying qualities tasks that require post-stall maneuvering were tested during piloted simulations in the McDonnell Douglas Aerospace Manned Air Combat Simulation facility. A generic fighter aircraft model was used to test angle of attack rate and pitch rate command systems for longitudinal gross acquisition and tracking tasks at high angle of attack. A wide range of longitudinal dynamic variations were tested at 30, 45, and 60 degrees angle of attack. Pilot comments, Cooper-Harper ratings, and pilot induced oscillation ratings were taken from five pilots from NASA, USN, CAF, and McDonnell Douglas Aerospace. This data was used to form longitudinal design guidelines for rate command systems at high angle of attack. These criteria provide control law design guidance for fighter aircraft at high angle of attack, low speed flight conditions. Additional time history analyses were conducted using the longitudinal gross acquisition data to look at potential agility measures of merit and correlate agility usage to flying qualities boundaries. This paper presents an overview of this research.

  6. Requirements of High-Quality Kindergarten Programs According to Jordanian Parents: An Exploratory Study

    ERIC Educational Resources Information Center

    Abu Taleb, Tagreed Fathi

    2013-01-01

    The main purpose of this study was to explore what Jordanian parents of children attending "traditional" kindergartens recognize as high-quality education programs. The sample consisted of 509 families ("N"?=?509) of kindergarten-age children. Data were collected using a three-part questionnaire: curriculum domains, teacher…

  7. Advancing High-Quality Preschool Inclusion: A Discussion and Recommendations for the Field

    ERIC Educational Resources Information Center

    Barton, Erin E.; Smith, Barbara J.

    2015-01-01

    Although considerable progress has been achieved regarding the research and laws supporting preschool inclusion, access to inclusive preschool environments remains intangible for many children with disabilities in the United States. The purpose of this article is to discuss current challenges and solutions to high-quality preschool inclusion. We…

  8. Access, Participation, and Supports: The Defining Features of High-Quality Inclusion

    ERIC Educational Resources Information Center

    Buysse, Virginia

    2011-01-01

    This article describes current knowledge about early childhood inclusion, summarizing research and the DEC/NAEYC joint position statement on inclusion. The article also describes effective or promising educational practices that promote access, participation, and supports--the defining features of high-quality inclusion. Future efforts to improve…

  9. Timing of High-Quality Child Care and Cognitive, Language, and Preacademic Development

    ERIC Educational Resources Information Center

    Li, Weilin; Farkas, George; Duncan, Greg J.; Burchinal, Margaret R.; Vandell, Deborah Lowe

    2013-01-01

    The effects of high- versus low-quality child care during 2 developmental periods (infant-toddlerhood and preschool) were examined using data from the National Institute of Child Health and Human Development Study of Early Child Care. Propensity score matching was used to account for differences in families who used different combinations of child…

  10. Emotional Experience, Expression, and Regulation of High-Quality Japanese Elementary School Teachers

    ERIC Educational Resources Information Center

    Hosotani, Rika; Imai-Matsumura, Kyoko

    2011-01-01

    The present study investigates the emotional experience, expression, and regulation processes of high-quality Japanese elementary school teachers while they interact with children, in terms of teachers' emotional competence. Qualitative analysis of interview data demonstrated that teachers had various emotional experiences including self-elicited…

  11. How Quality of Writing Instruction Impacts High-Risk Fourth Graders' Writing

    ERIC Educational Resources Information Center

    Moats, Louisa; Foorman, Barbara; Taylor, Patrick

    2006-01-01

    From a larger longitudinal study of 610 fourth graders in 17 inner city schools, 40 students were randomly selected from 10 classrooms rated high (i.e., top quartile) or low (i.e., bottom quartile) in quality of writing instruction in grades 3 and 4. The written compositions of these students were scored in three ways: (1) according to a rating…

  12. Soaring Systems: High Flyers All Have Equitable Funding, Shared Curriculum, and Quality Teaching

    ERIC Educational Resources Information Center

    Darling-Hammond, Linda

    2011-01-01

    Now more than ever, high-quality education for all is a public good that is essential for the good of the public. As the fate of individuals and nations is increasingly interdependent, the quest for access to an equitable, empowering education for all people has become a critical issue for the American nation as a whole. No society can thrive in a…

  13. Vendors Future: Northern Light--Delivering High-Quality Content to a Large Internet Audience.

    ERIC Educational Resources Information Center

    Wiggins, Richard

    1997-01-01

    Describes a Web-based information service, Northern Light, which demonstrates a new paradigm for serving large populations of users and delivering high-quality content on topics both general and narrow. Discusses performance of the search engine, search syntax, Northern Light's special collection, and pricing. (AEF)

  14. Publishing in High Quality Journals: Perspectives from Overworked and Unpaid Reviewers

    ERIC Educational Resources Information Center

    Bol, Linda; Hacker, Douglas J.

    2014-01-01

    Our purpose for this article is to provide suggestions on how to get your high quality research published from the perspectives of reviewers. First, good writing is good thinking, and you are much more likely to succeed when you combine good writing with sound research. We then offer an eight-step method of reviewing that may help the author…

  15. School District Wellness Policy Quality and Weight-Related Outcomes among High School Students in Minnesota

    ERIC Educational Resources Information Center

    Hoffman, Pamela K.; Davey, Cynthia S.; Larson, Nicole; Grannon, Katherine Y.; Hanson, Carlie; Nanney, Marilyn S.

    2016-01-01

    Weight-related outcomes were examined among high school students in Minnesota public school districts according to the quality of district wellness policies. Wellness policy strength and comprehensiveness were scored using the Wellness School Assessment Tool (WellSAT) for 325 Minnesota public school districts in 2013. The associations between…

  16. Baishideng’s century goal: Editing and publishing high-quality articles

    PubMed Central

    Ma, Lian-Sheng

    2009-01-01

    Baishideng’s goal over the next few years is to edit and publish high-quality articles through the open-access model, to maximize the benefits to members of the editorial board, authors and readers, as well as achieving social and economic benefits. PMID:19701962

  17. Creating and Sustaining High-Quality Charter School Governing Boards. A Guide for State Policymakers

    ERIC Educational Resources Information Center

    Butler, Elizabeth A.

    2008-01-01

    This guide for state policymakers examines the laws, policies, and programs that states are using to create and sustain high-quality charter school governing boards. In particular, the guide focuses on the two aspects of governing boards that interviews with state administrators revealed are most critical for a board's success: board composition…

  18. Forming a Team to Ensure High-Quality Measurement in Education Studies. REL 2014-052

    ERIC Educational Resources Information Center

    Kisker, Ellen Eliason; Boller, Kimberly

    2014-01-01

    This brief provides tips for forming a team of staff and consultants with the needed expertise to make key measurement decisions that will ensure high-quality data for answering the study's research questions. The brief outlines the main responsibilities of measurement team members. It also describes typical measurement tasks and discusses…

  19. Does Access to High Quality Early Education Vary by State Policy Context?

    ERIC Educational Resources Information Center

    Connors, Maia C.; Morris, Pamela A.; Friedman-Krauss, Allison H.

    2015-01-01

    Research suggests that attending high quality, formal early childhood education (ECE) is associated with stronger cognitive and social-emotional skills, especially for low-income children. Yet at current funding levels, federally-funded programs like Head Start cannot serve all eligible children. Thus, state-level policies governing the…

  20. Rocking curve imaging of high quality sapphire crystals in backscattering geometry

    DOE PAGES

    Jafari, A.; European Synchrotron Radiation Facility; Univ. of Liege,; ...

    2017-01-23

    Here, we report on the characterization of high quality sapphire single crystals suitable for high-resolution X-ray optics at high energy. Investigations using rocking curve imaging reveal the crystals to be of uniformly good quality at the level of ~10-4 in lattice parameter variations, deltad/d. But, investigations using backscattering rocking curve imaging with lattice spacing resolution of deltad/d ~ 5.10-8 shows very diverse quality maps for all crystals. Our results highlight nearly ideal areas with edge length of 0.2-0.5 mm in most crystals, but a comparison of the back re ection peak positions shows that even neighboring ideal areas exhibit amore » relative difference in the lattice parameters on the order of deltad/d = 10-20.10-8; this is several times larger than the rocking curve width. Furthermore, the stress-strain analysis suggests that an extremely stringent limit on the strain at a level of ~100 kPa in the growth process is required in order to produce crystals with large areas of the quality required for X-ray optics at high energy.« less

  1. High-Quality College and Career Ready Assessments. re:VISION

    ERIC Educational Resources Information Center

    Martin, Michael

    2015-01-01

    Assessments matter in education. Testing is nothing new; tests have been around as long as school itself. However, over the last 15 years, state assessments have grown to be an increasingly central, and often controversial, part of schooling. As states raise their standards, it is more important than ever to ask: What is a high-quality assessment?…

  2. High-Quality Professional Development in Physical Education: The Role of a Subject Association

    ERIC Educational Resources Information Center

    Keay, Jeanne; Lloyd, Christine

    2009-01-01

    In this article, we report on a longitudinal action research project undertaken to explore the role that a subject association in the United Kingdom has chosen to play in ensuring that continuing professional development (CPD) provided for its members is of high quality. The Professional Development Board for Physical Education, which functions…

  3. Benefits of High Quality Childcare for Low-Income Mothers: The Abecedarian Study.

    ERIC Educational Resources Information Center

    Pungello, Elizabeth; Campbell, Frances A.; Miller-Johnson, Shari

    This follow-up study examined the long-term effects of providing 5 years of high-quality childcare for low-income mothers participating in the Abecedarian study, a randomized trial of early childhood educational intervention for children from low-income families. Participating in the age-21 follow-up were 100 of the original 109 biological…

  4. What Constitutes High-Quality Discussion in Science? Research from the Perspectives on Science Course

    ERIC Educational Resources Information Center

    Levinson, Ralph; Hand, Michael; Amos, Ruth

    2012-01-01

    Perspectives on Science (POS) is a unique research-based post-16 course that addresses the history, philosophy and ethical aspects of science. Our central research question was to what extent is POS successful in promoting high-quality discussion in class and what factors influence this. Through questionnaires, interviews and observations of…

  5. Animated Cell Biology: A Quick and Easy Method for Making Effective, High-Quality Teaching Animations

    ERIC Educational Resources Information Center

    O'Day, Danton H.

    2006-01-01

    There is accumulating evidence that animations aid learning of dynamic concepts in cell biology. However, existing animation packages are expensive and difficult to learn, and the subsequent production of even short animations can take weeks to months. Here I outline the principles and sequence of steps for producing high-quality PowerPoint…

  6. Rocking curve imaging of high quality sapphire crystals in backscattering geometry

    NASA Astrophysics Data System (ADS)

    Jafari, A.; Sergueev, I.; Bessas, D.; Klobes, B.; Roschin, B. S.; Asadchikov, V. E.; Alexeev, P.; Härtwig, J.; Chumakov, A. I.; Wille, H.-C.; Hermann, R. P.

    2017-01-01

    We report on the characterization of high quality sapphire single crystals suitable for high-resolution X-ray optics at high energy. Investigations using rocking curve imaging reveal the crystals to be of uniformly good quality at the level of ˜10-4 in lattice parameter variations, δd /d . However, investigations using backscattering rocking curve imaging with a lattice spacing resolution of δd /d ˜5 ×10-8 show very diverse quality maps for all crystals. Our results highlight nearly ideal areas with an edge length of 0.2-0.5 mm in most crystals, but a comparison of the back reflection peak positions shows that even neighboring ideal areas exhibit a relative difference in the lattice parameters on the order of δd /d =10 - 20 ×10-8 ; this is several times larger than the rocking curve width. Stress-strain analysis suggests that an extremely stringent limit on the strain at a level of ˜100 kPa in the growth process is required in order to produce crystals with large areas of the quality required for X-ray optics at high energy.

  7. Study on the Introduction of High-Quality Educational Resources for Sino-Foreign Cooperative Education

    ERIC Educational Resources Information Center

    Jinhui, Lin

    2016-01-01

    In Sino-foreign cooperative education, high-quality introduced educational resources must benefit the growth and development of students, facilitate the school's capacity building and the improvement of overall educational standards, and promote national socioeconomic development. It is necessary to establish and perfect the various working…

  8. 200 Hz repetition frequency joule-level high beam quality Nd:YAG nanosecond laser

    NASA Astrophysics Data System (ADS)

    Qiu, Jisi; Tang, Xiongxin; Fan, Zhongwei; Wang, Haocheng

    2016-06-01

    A joule-level Nd:YAG nanosecond laser of high repetition frequency and high beam quality is developed out. The laser is designed as a MOPA system mainly including single longitudinal mode seed, pre-amplifier unit an d power amplifier unit. In order to obtain the high-quality laser beam output, phase conjugation is adopted to compensate the laser beam distortion. Under the condition of 200 Hz high repetition frequency and 8.19 μJ single pulse energy injected by the single longitudinal mode seed, 1.53 J output energy is gained. The output laser beam is of 9 mm diameter, 7.41 ns pulse width, the far field beam spot 1.32 times the value of the diffraction limit, 1.2% energy stability (RMS) and less than 13 μrad far field beam spot angle shift.

  9. Mapping bare soil in South West Wales, UK, using high resolution colour infra-red aerial photography for water quality and flood risk management applications

    NASA Astrophysics Data System (ADS)

    Sykes, Helena; Neale, Simon; Coe, Sarah

    2016-04-01

    Natural Resources Wales is a UK government body responsible for environmental regulation, among other areas. River walks in Water Framework Directive (WFD) priority catchments in South West Wales, UK, identified soil entering water courses due to poaching and bank erosion, leading to deterioration in the water quality and jeopardising the water quality meeting legal minimum standards. Bare soil has also been shown to cause quicker and higher hydrograph peaks in rural catchments than if those areas were vegetated, which can lead to flooding of domestic properties during peak storm flows. The aim was to target farm visits by operational staff to advise on practices likely to improve water quality and to identify areas where soft engineering solutions such as revegetation could alleviate flood risk in rural areas. High resolution colour-infrared aerial photography, 25cm in the three colour bands and 50cm in the near infrared band, was used to map bare soil in seven catchments using supervised classification of a five band stack including the Normalised Difference Vegetation Index (NDVI). Mapping was combined with agricultural land use and field boundary data to filter out arable fields, which are supposed to bare soil for part of their cycle, and was very successful when compared to ground truthing, with the exception of silage fields which contained sparse, no or unproductive vegetation at the time the imagery was acquired leading to spectral similarity to bare soil. A raindrop trace model was used to show the path sediment from bare soil areas would take when moving through the catchment to a watercourse, with hedgerows inserted as barriers following our observations from ground truthing. The findings have been used to help farmers gain funding for improvements such as fencing to keep animals away from vulnerable river banks. These efficient and automated methods can be rolled out to more catchments in Wales and updated using aerial imagery acquired more recently to

  10. Lateral-Directional Eigenvector Flying Qualities Guidelines for High Performance Aircraft

    NASA Technical Reports Server (NTRS)

    Davidson, John B.; Andrisani, Dominick, II

    1996-01-01

    This report presents the development of lateral-directional flying qualities guidelines with application to eigenspace (eigenstructure) assignment methods. These guidelines will assist designers in choosing eigenvectors to achieve desired closed-loop flying qualities or performing trade-offs between flying qualities and other important design requirements, such as achieving realizable gain magnitudes or desired system robustness. This has been accomplished by developing relationships between the system's eigenvectors and the roll rate and sideslip transfer functions. Using these relationships, along with constraints imposed by system dynamics, key eigenvector elements are identified and guidelines for choosing values of these elements to yield desirable flying qualities have been developed. Two guidelines are developed - one for low roll-to-sideslip ratio and one for moderate-to-high roll-to-sideslip ratio. These flying qualities guidelines are based upon the Military Standard lateral-directional coupling criteria for high performance aircraft - the roll rate oscillation criteria and the sideslip excursion criteria. Example guidelines are generated for a moderate-to-large, an intermediate, and low value of roll-to-sideslip ratio.

  11. High cardiac vagal control is related to better subjective and objective sleep quality

    PubMed Central

    Werner, Gabriela G.; Ford, Brett Q.; Mauss, Iris B.; Schabus, Manuel; Blechert, Jens; Wilhelm, Frank H.

    2015-01-01

    Cardiac vagal control (CVC) has been linked to both physical and mental health. One critical aspect of health, that has not received much attention, is sleep. We hypothesized that adults with higher CVC – operationalized by high-frequency heart rate variability (HF-HRV) – will exhibit better sleep quality assessed both subjectively (i.e., with Pittsburgh Sleep Quality Index) and objectively (i.e., with polysomnography). HF-HRV was measured in 29 healthy young women during an extended neutral film clip. Participants then underwent full polysomnography to obtain objective measures of sleep quality and HF-HRV during a night of sleep. As expected, higher resting HF-HRV was associated with higher subjective and objective sleep quality (i.e., shorter sleep latency and fewer arousals). HF-HRV during sleep (overall or separated by sleep phases) showed less consistent relationships with sleep quality. These findings indicate that high waking CVC may be a key predictor of healthy sleep. PMID:25709072

  12. Molecular Beam Epitaxy Growth of High Crystalline Quality LiNbO3

    NASA Astrophysics Data System (ADS)

    Tellekamp, M. Brooks; Shank, Joshua C.; Goorsky, Mark S.; Doolittle, W. Alan

    2016-12-01

    Lithium niobate is a multi-functional material with wide reaching applications in acoustics, optics, and electronics. Commercial applications for lithium niobate require high crystalline quality currently limited to bulk and ion sliced material. Thin film lithium niobate is an attractive option for a variety of integrated devices, but the research effort has been stagnant due to poor material quality. Both lattice matched and mismatched lithium niobate are grown by molecular beam epitaxy and studied to understand the role of substrate and temperature on nucleation conditions and material quality. Growth on sapphire produces partially coalesced columnar grains with atomically flat plateaus and no twin planes. A symmetric rocking curve shows a narrow linewidth with a full width at half-maximum (FWHM) of 8.6 arcsec (0.0024°), which is comparable to the 5.8 arcsec rocking curve FWHM of the substrate, while the film asymmetric rocking curve is 510 arcsec FWHM. These values indicate that the individual grains are relatively free of long-range disorder detectable by x-ray diffraction with minimal measurable tilt and twist and represents the highest structural quality epitaxial material grown on lattice mismatched sapphire without twin planes. Lithium niobate is also grown on lithium tantalate producing high quality coalesced material without twin planes and with a symmetric rocking curve of 193 arcsec, which is nearly equal to the substrate rocking curve of 194 arcsec. The surface morphology of lithium niobate on lithium tantalate is shown to be atomically flat by atomic force microscopy.

  13. A quality assurance initiative for commercial-scale production in high-throughput cryopreservation of blue catfish sperm.

    PubMed

    Hu, E; Liao, T W; Tiersch, T R

    2013-10-01

    Cryopreservation of fish sperm has been studied for decades at a laboratory (research) scale. However, high-throughput cryopreservation of fish sperm has recently been developed to enable industrial-scale production. This study treated blue catfish (Ictalurus furcatus) sperm high-throughput cryopreservation as a manufacturing production line and initiated quality assurance plan development. The main objectives were to identify: (1) the main production quality characteristics; (2) the process features for quality assurance; (3) the internal quality characteristics and their specification designs; (4) the quality control and process capability evaluation methods, and (5) the directions for further improvements and applications. The essential product quality characteristics were identified as fertility-related characteristics. Specification design which established the tolerance levels according to demand and process constraints was performed based on these quality characteristics. Meanwhile, to ensure integrity throughout the process, internal quality characteristics (characteristics at each quality control point within process) that could affect fertility-related quality characteristics were defined with specifications. Due to the process feature of 100% inspection (quality inspection of every fish), a specific calculation method, use of cumulative sum (CUSUM) control charts, was applied to monitor each quality characteristic. An index of overall process evaluation, process capacity, was analyzed based on in-control process and the designed specifications, which further integrates the quality assurance plan. With the established quality assurance plan, the process could operate stably and quality of products would be reliable.

  14. Indoor Air Quality in 24 California Residences Designed as High-Performance Homes

    SciTech Connect

    Less, Brennan; Mullen, Nasim; Singer, Brett; Walker, Iain

    2015-07-01

    Today’s high performance green homes are reaching previously unheard of levels of airtightness and are using new materials, technologies and strategies, whose impacts on Indoor Air Quality (IAQ) cannot be fully anticipated from prior studies. This research study used pollutant measurements, home inspections, diagnostic testing and occupant surveys to assess IAQ in 24 new or deeply retrofitted homes designed to be high performance green buildings in California.

  15. Fabrication of precision high quality facets on molecular beam epitaxy material

    DOEpatents

    Petersen, Holly E.; Goward, William D.; Dijaili, Sol P.

    2001-01-01

    Fabricating mirrored vertical surfaces on semiconductor layered material grown by molecular beam epitaxy (MBE). Low energy chemically assisted ion beam etching (CAIBE) is employed to prepare mirrored vertical surfaces on MBE-grown III-V materials under unusually low concentrations of oxygen in evacuated etching atmospheres of chlorine and xenon ion beams. UV-stabilized smooth-surfaced photoresist materials contribute to highly vertical, high quality mirrored surfaces during the etching.

  16. Longitudinal Splitting of Boron Nitride Nanotubes for the Facile Synthesis of High Quality Boron Nitride Nanoribbons

    DTIC Science & Technology

    2011-05-24

    Boron Nitride Nanotubes for the Facile Synthesis of High Quality Boron Nitride Nanoribbons Kris J. Erickson,†,‡,§ Ashley...We report the synthesis of BNNRs through the potassium-intercalation-induced longitudinal splitting of boron nitride nanotubes (BNNTs). This facile...COVERED 00-00-2011 to 00-00-2011 4. TITLE AND SUBTITLE Longitudinal Splitting of Boron Nitride Nanotubes for the Facile Synthesis of High

  17. New CVD-based method for the growth of high-quality crystalline zinc oxide layers

    NASA Astrophysics Data System (ADS)

    Huber, Florian; Madel, Manfred; Reiser, Anton; Bauer, Sebastian; Thonke, Klaus

    2016-07-01

    High-quality zinc oxide (ZnO) layers were grown using a new chemical vapour deposition (CVD)-based low-cost growth method. The process is characterized by total simplicity, high growth rates, and cheap, less hazardous precursors. To produce elementary zinc vapour, methane (CH4) is used to reduce a ZnO powder. By re-oxidizing the zinc with pure oxygen, highly crystalline ZnO layers were grown on gallium nitride (GaN) layers and on sapphire substrates with an aluminum nitride (AlN) nucleation layer. Using simple CH4 as precursor has the big advantage of good controllability and the avoidance of highly toxic gases like nitrogen oxides. In photoluminescence (PL) measurements the samples show a strong near-band-edge emission and a sharp line width at 5 K. The good crystal quality has been confirmed in high resolution X-ray diffraction (HRXRD) measurements. This new growth method has great potential for industrial large-scale production of high-quality single crystal ZnO layers.

  18. Does a "Level I Evidence" rating imply high quality of reporting in orthopaedic randomised controlled trials?

    PubMed Central

    Poolman, Rudolf W; Struijs, Peter AA; Krips, Rover; Sierevelt, Inger N; Lutz, Kristina H; Bhandari, Mohit

    2006-01-01

    of Evidence Rating System criteria assessors achieved substantial agreement (ICC = 0.80, 95%CI:0.60 to 0.90). Conclusion Our findings suggest that readers should not assume that 1) studies labelled as Level I have high reporting quality and 2) Level I studies have better reporting quality than Level II studies. One should address methodological safeguards individually. PMID:16965628

  19. Growth of high quality germanium films on patterned silicon substrates and applications

    NASA Astrophysics Data System (ADS)

    Vanamu, Ganesh

    The principal objective of this work is to determine optimal pattern structures for highest quality (defect free) heteroepitaxial growth. High quality films of Ge on Si are of significant importance and can be used in high electron mobility devices, photodetectors for optical communications (1.3mum or 1.55mum) and integrating III-V optoelectronic devices. However, a 4% lattice mismatch and ˜ 50% thermal expansion mismatch between Ge and Si create three major challenges in growing high quality Ge films on Si, (a) high surface roughness due to a pronounced <110> crosshatch pattern, (b) high dislocation densities in Ge films and (c) high density of microcracks and wafer bending. A common way of reducing lattice and thermal expansion mismatch is to form a "virtual substrate (VS)" by growing a graded composition followed by a uniform layer of the desired epitaxial film on a defect-free Si substrate. Virtual graded layers could not decrease the dislocation densities to the numbers acceptable for most of the devices. Mathews et al. first proposed that limiting the lateral dimensions of the sample prior to growth could reduce the dislocation density. Later On Fitzgerald proposed that patterning decreases the dislocation density in the films. In this work we show high quality crosshatch-free Ge films with dislocation density ˜ 105 cm-2 on the nano-patterned Si and also high quality GaAs films on the Ge/Si virtual substrate. The first step in this research was to perform a systematic study to identify the role of pattern width on the quality of Ge growth. We investigated micrometer and submicrometer scale patterns. We demonstrated that the quality of the heteroepitaxial layers improves as the pattern width decreases. Then we have decreased the pattern width to nanometer-scale dimensions. Significant improvement of the Ge film quality was observed. We used novel interferometric lithography techniques combined with reactive ion and wet chemical etching to fabricate Si

  20. Occupationally Acquired American Cutaneous Leishmaniasis

    PubMed Central

    Felinto de Brito, Maria Edileuza; Andrade, Maria Sandra; de Almeida, Éricka Lima; Medeiros, Ângela Cristina Rapela; Werkhäuser, Roberto Pereira; de Araújo, Ana Isabele Freitas; Brandão-Filho, Sinval Pinto; Paiva de Almeida, Alzira Maria; Gomes Rodrigues, Eduardo Henrique

    2012-01-01

    We report two occupationally acquired cases of American cutaneous leishmaniasis (ACL): one accidental laboratory autoinoculation by contaminated needlestick while handling an ACL lesion sample, and one acquired during field studies on bird biology. Polymerase chain reaction (PCR) assays of patient lesions were positive for Leishmania, subgenus Viannia. One isolate was obtained by culture (from patient 2 biopsy samples) and characterized as Leishmania (Viannia) naiffi through an indirect immunofluorescence assay (IFA) with species-specific monoclonal antibodies (mAbs) and by multilocus enzyme electrophoresis (MLEE). Patients were successfully treated with N-methyl-glucamine. These two cases highlight the potential risks of laboratory and field work and the need to comply with strict biosafety procedures in daily routines. The swab collection method, coupled with PCR detection, has greatly improved ACL laboratory diagnosis. PMID:23227369

  1. TH-E-17A-09: High Quality and Artifact-Free 4D Cone Beam CT and Its Application in Adaptive Treatment Planning

    SciTech Connect

    Niu, K; Li, K; Smilowitz, J; Chen, G

    2014-06-15

    Purpose: To develop a high quality 4D cone beam CT (4DCBCT) method that is immune to patient/couch truncations and to investigate its application in adaptive replanning of lung XRT. Methods: In this study, IRB-approved human subject CBCT data was acquired using a Varian on-board imager with 1 minute rotation time. The acquired projection data was retrospectively sorted into 20 respiratory phase bins, from which 4DCBCT images with high SNR and high temporal resolution were generated using Prior Image Constrained Compressed Sensing (PICCS). Couch and patient truncations generate strong data inconsistency in the projection data and artifacts in the 4DCBCT image. They were addressed using an adaptive PICCS method. The artifact-free PICCS-4DCBCT images were used to generate adaptive treatment plans for the same patient at the 10th (day 21) and 30th (day 47) fractions. Dosimetric impacts with and without PICCS- 4DCBCT were evaluated by isodose distributions, DVHs, and other dosimetric factors. Results: The adaptive PICCS-4DCBCT method improves image quality by removing residue truncation artifacts; measured universal image quality increased 37%. The isodose lines and DVHs with PICCS-4DCBCT-based adaptive replanning were significantly more conformal to PTV than without replanning due to changes in patient anatomy caused by progress of the treatment. The mean dose to PTV at the 10th fraction was 63.1Gy with replanning and 64.2Gy without replanning, where the prescribed dose was 60Gy, in 2Gy × 30 fractions. The mean dose to PTV at the 30th fraction was 61.6Gy with replanning and 64.9Gy without replanning. Lung V20 was 37.1%, 41.9% and 43.3% for original plan, 10th fraction plan and 30th fraction plan; with re-planning, Lung V20 was 37.1%, 32%, 27.8%. Conclusion: 4DCBCT imaging using adaptive PICCS is able to generate high quality, artifact-free images that potentially can be used to create replanning for improving radiotherapy of the lung. K Niu, K Li, J Smilowitz: Nothing

  2. [Acquired disorders of color vision].

    PubMed

    Lascu, Lidia; Balaş, Mihaela

    2002-01-01

    This article is a general view of acquired disorders of color vision. The revision of the best known methods and of the etiopathogenic classification is not very important in ophthalmology but on the other hand, the detection of the blue defect advertise and associated ocular pathology. There is a major interest in serious diseases as multiple sclerosis, AIDS, diabetes melitus, when the first ocular sign can be a defect in the color vision.

  3. High-Density, High-Resolution, Low-Cost Air Quality Sensor Networks for Urban Air Monitoring

    NASA Astrophysics Data System (ADS)

    Mead, M. I.; Popoola, O. A.; Stewart, G.; Bright, V.; Kaye, P.; Saffell, J.

    2012-12-01

    Monitoring air quality in highly granular environments such as urban areas which are spatially heterogeneous with variable emission sources, measurements need to be made at appropriate spatial and temporal scales. Current routine air quality monitoring networks generally are either composed of sparse expensive installations (incorporating e.g. chemiluminescence instruments) or higher density low time resolution systems (e.g. NO2 diffusion tubes). Either approach may not accurately capture important effects such as pollutant "hot spots" or adequately capture spatial (or temporal) variability. As a result, analysis based on data from traditional low spatial resolution networks, such as personal exposure, may be inaccurate. In this paper we present details of a sophisticated, low-cost, multi species (gas phase, speciated PM, meteorology) air quality measurement network methodology incorporating GPS and GPRS which has been developed for high resolution air quality measurements in urban areas. Sensor networks developed in the Centre for Atmospheric Science (University of Cambridge) incorporated electrochemical gas sensors configured for use in urban air quality studies operating at parts-per-billion (ppb) levels. It has been demonstrated that these sensors can be used to measure key air quality gases such as CO, NO and NO2 at the low ppb mixing ratios present in the urban environment (estimated detection limits <4ppb for CO and NO and <1ppb for NO2. Mead et al (submitted Aug., 2012)). Based on this work, a state of the art multi species instrument package for deployment in scalable sensor networks has been developed which has general applicability. This is currently being employed as part of a major 3 year UK program at London Heathrow airport (the Sensor Networks for Air Quality (SNAQ) Heathrow project). The main project outcome is the creation of a calibrated, high spatial and temporal resolution data set for O3, NO, NO2, SO2, CO, CO2, VOCstotal, size-speciated PM

  4. High-quality image magnification applying Gerchberg-Papoulis iterative algorithm with discrete cosine transform

    NASA Astrophysics Data System (ADS)

    Shinbori, Eiji; Takagi, Mikio

    1992-11-01

    A new image magnification method, called 'IM-GPDCT' (image magnification applying the Gerchberg-Papoulis (GP) iterative algorithm with discrete cosine transform (DCT)), is described and its performance evaluated. This method markedly improves image quality of a magnified image using a concept which restores the spatial high frequencies which are conventionally lost due to use of a low pass filter. These frequencies are restored using two known constraints applied during iterative DCT: (1) correct information in a passband is known and (2) the spatial extent of an image is finite. Simulation results show that the IM- GPDCT outperforms three conventional interpolation methods from both a restoration error and image quality standpoint.

  5. Growth of high quality bulk size single crystals of inverted solubility lithium sulphate monohydrate

    SciTech Connect

    Silambarasan, A.; Rajesh, P. Ramasamy, P.

    2015-06-24

    The paper summarizes the processes of growing large lithium sulfate monohydrate (LSMH) single crystals. We have established a procedure to grow high quality bulk size single crystals of inverted solubility LSMH by a newly developed unidirectional crystallization technique called the Sankeranarayenan - Ramasamy (SR) method. The convective flow of crystal growth processes from solution and the conditions of growing crystals of various aspects were discussed. Good quality LSMH single crystal is grown of the size 20 mmX80 mm without cracks, localized-defects and inclusions. The as-grown crystals are suitable for piezoelectric and nonlinear optical applications.

  6. a Distributed Control and Data Base System for the Production of High Quality Crystals

    NASA Astrophysics Data System (ADS)

    Vialle, Jean-Pierre

    The construction of the high precision crystal electromagnetic calorimeter of the CMS experiment at LHC will require about 3 production factories and 4 assembly sites spread over the world, and will last 5 to 6 years. A quality control scheme will have to be setup to achieve the required performances. It will imposes methods like the ISO 9000 quality insurance scheme, and the use of object-oriented database for storing the information, with a query and control system based on W3 to make the analysis accessible to any member of the world-wide collaboration.

  7. High-quality, highly concentrated semiconducting single-wall carbon nanotubes for use in field effect transistors and biosensors.

    PubMed

    Li, Wen-Shan; Hou, Peng-Xiang; Liu, Chang; Sun, Dong-Ming; Yuan, Jiangtan; Zhao, Shi-Yong; Yin, Li-Chang; Cong, Hongtao; Cheng, Hui-Ming

    2013-08-27

    We developed a simple and scalable selective synthesis method of high-quality, highly concentrated semiconducting single-wall carbon nanotubes (s-SWCNTs) by in situ hydrogen etching. Samples containing ~93% s-SWCNTs were obtained in bulk. These s-SWCNTs with good structural integrity showed a high oxidation resistance temperature of ~800 °C. Thin-film transistors based on the s-SWCNTs demonstrated a high carrier mobility of 21.1 cm(2) V(-1) s(-1) at an on/off ratio of 1.1 × 10(4) and a high on/off ratio of 4.0 × 10(5) with a carrier mobility of 7.0 cm(2) V(-1) s(-1). A biosensor fabricated using the s-SWCNTs had a very low dopamine detection limit of 10(-18) mol/L at room temperature.

  8. Edge Polynomial Fractal Compression Algorithm for High Quality Video Transmission. Final report

    SciTech Connect

    Lin, Freddie

    1999-06-01

    In this final report, Physical Optics Corporation (POC) provides a review of its Edge Polynomial Autonomous Compression (EPAC) technology. This project was undertaken to meet the need for low bandwidth transmission of full-motion video images. In addition, this report offers a synopsis of the logical data representation study that was performed to compress still images and video. The mapping singularities and polynomial representation of 3-D surfaces were found to be ideal for very high image compression. Our efforts were then directed to extending the EPAC algorithm for the motion of singularities by tracking the 3-D coordinates of characteristic points and the development of system components. Finally, we describe the integration of the software with the hardware components. This process consists of acquiring and processing each separate camera view, combining the information from different cameras to calculate the location of an object in three dimensions, and tracking the information history and the behavior of the objects.

  9. Designing a Broadband Pump for High-Quality Micro-Lasers via Modified Net Radiation Method

    NASA Astrophysics Data System (ADS)

    Nechayev, Sergey; Reusswig, Philip D.; Baldo, Marc A.; Rotschild, Carmel

    2016-12-01

    High-quality micro-lasers are key ingredients in non-linear optics, communication, sensing and low-threshold solar-pumped lasers. However, such micro-lasers exhibit negligible absorption of free-space broadband pump light. Recently, this limitation was lifted by cascade energy transfer, in which the absorption and quality factor are modulated with wavelength, enabling non-resonant pumping of high-quality micro-lasers and solar-pumped laser to operate at record low solar concentration. Here, we present a generic theoretical framework for modeling the absorption, emission and energy transfer of incoherent radiation between cascade sensitizer and laser gain media. Our model is based on linear equations of the modified net radiation method and is therefore robust, fast converging and has low complexity. We apply this formalism to compute the optimal parameters of low-threshold solar-pumped lasers. It is revealed that the interplay between the absorption and self-absorption of such lasers defines the optimal pump absorption below the maximal value, which is in contrast to conventional lasers for which full pump absorption is desired. Numerical results are compared to experimental data on a sensitized Nd3+:YAG cavity, and quantitative agreement with theoretical models is found. Our work modularizes the gain and sensitizing components and paves the way for the optimal design of broadband-pumped high-quality micro-lasers and efficient solar-pumped lasers.

  10. Designing a Broadband Pump for High-Quality Micro-Lasers via Modified Net Radiation Method.

    PubMed

    Nechayev, Sergey; Reusswig, Philip D; Baldo, Marc A; Rotschild, Carmel

    2016-12-07

    High-quality micro-lasers are key ingredients in non-linear optics, communication, sensing and low-threshold solar-pumped lasers. However, such micro-lasers exhibit negligible absorption of free-space broadband pump light. Recently, this limitation was lifted by cascade energy transfer, in which the absorption and quality factor are modulated with wavelength, enabling non-resonant pumping of high-quality micro-lasers and solar-pumped laser to operate at record low solar concentration. Here, we present a generic theoretical framework for modeling the absorption, emission and energy transfer of incoherent radiation between cascade sensitizer and laser gain media. Our model is based on linear equations of the modified net radiation method and is therefore robust, fast converging and has low complexity. We apply this formalism to compute the optimal parameters of low-threshold solar-pumped lasers. It is revealed that the interplay between the absorption and self-absorption of such lasers defines the optimal pump absorption below the maximal value, which is in contrast to conventional lasers for which full pump absorption is desired. Numerical results are compared to experimental data on a sensitized Nd(3+):YAG cavity, and quantitative agreement with theoretical models is found. Our work modularizes the gain and sensitizing components and paves the way for the optimal design of broadband-pumped high-quality micro-lasers and efficient solar-pumped lasers.

  11. High-quality construction of analysis-suitable trivariate NURBS solids by reparameterization methods

    NASA Astrophysics Data System (ADS)

    Xu, Gang; Mourrain, Bernard; Galligo, André; Rabczuk, Timon

    2014-11-01

    High-quality volumetric parameterization of computational domain plays an important role in three-dimensional isogeometric analysis. Reparameterization technique can improve the distribution of isoparametric curves/surfaces without changing the geometry. In this paper, using the reparameterization method, we investigate the high-quality construction of analysis-suitable NURBS volumetric parameterization. Firstly, we introduce the concept of volumetric reparameterization, and propose an optimal Möbius transformation to improve the quality of the isoparametric structure based on a new uniformity metric. Secondly, from given boundary NURBS surfaces, we present a two-stage scheme to construct the analysis-suitable volumetric parameterization: in the first step, uniformity-improved reparameterization is performed on the boundary surfaces to achieve high-quality isoparametric structure without changing the shape; in the second step, from a new variational harmonic metric and the reparameterized boundary surfaces, we construct the optimal inner control points and weights to achieve an analysis-suitable NURBS solid. Several examples with complicated geometry are presented to illustrate the effectiveness of proposed methods.

  12. An improved multi-exposure approach for high quality holographic femtosecond laser patterning

    SciTech Connect

    Zhang, Chenchu; Hu, Yanlei E-mail: jwl@ustc.edu.cn; Li, Jiawen E-mail: jwl@ustc.edu.cn; Lao, Zhaoxin; Ni, Jincheng; Chu, Jiaru; Huang, Wenhao; Wu, Dong

    2014-12-01

    High efficiency two photon polymerization through single exposure via spatial light modulator (SLM) has been used to decrease the fabrication time and rapidly realize various micro/nanostructures, but the surface quality remains a big problem due to the speckle noise of optical intensity distribution at the defocused plane. Here, a multi-exposure approach which used tens of computer generate holograms successively loaded on SLM is presented to significantly improve the optical uniformity without losing efficiency. By applying multi-exposure, we found that the uniformity at the defocused plane was increased from ∼0.02 to ∼0.6 according to our simulation. The fabricated two series of letters “HELLO” and “USTC” under single-and multi-exposure in our experiment also verified that the surface quality was greatly improved. Moreover, by this method, several kinds of beam splitters with high quality, e.g., 2 × 2, 5 × 5 Daman, and complex nonseperate 5 × 5, gratings were fabricated with both of high quality and short time (<1 min, 95% time-saving). This multi-exposure SLM-two-photon polymerization method showed the promising prospect in rapidly fabricating and integrating various binary optical devices and their systems.

  13. An improved multi-exposure approach for high quality holographic femtosecond laser patterning

    NASA Astrophysics Data System (ADS)

    Zhang, Chenchu; Hu, Yanlei; Li, Jiawen; Lao, Zhaoxin; Ni, Jincheng; Chu, Jiaru; Huang, Wenhao; Wu, Dong

    2014-12-01

    High efficiency two photon polymerization through single exposure via spatial light modulator (SLM) has been used to decrease the fabrication time and rapidly realize various micro/nanostructures, but the surface quality remains a big problem due to the speckle noise of optical intensity distribution at the defocused plane. Here, a multi-exposure approach which used tens of computer generate holograms successively loaded on SLM is presented to significantly improve the optical uniformity without losing efficiency. By applying multi-exposure, we found that the uniformity at the defocused plane was increased from ˜0.02 to ˜0.6 according to our simulation. The fabricated two series of letters "HELLO" and "USTC" under single-and multi-exposure in our experiment also verified that the surface quality was greatly improved. Moreover, by this method, several kinds of beam splitters with high quality, e.g., 2 × 2, 5 × 5 Daman, and complex nonseperate 5 × 5, gratings were fabricated with both of high quality and short time (<1 min, 95% time-saving). This multi-exposure SLM-two-photon polymerization method showed the promising prospect in rapidly fabricating and integrating various binary optical devices and their systems.

  14. Designing a Broadband Pump for High-Quality Micro-Lasers via Modified Net Radiation Method

    PubMed Central

    Nechayev, Sergey; Reusswig, Philip D.; Baldo, Marc A.; Rotschild, Carmel

    2016-01-01

    High-quality micro-lasers are key ingredients in non-linear optics, communication, sensing and low-threshold solar-pumped lasers. However, such micro-lasers exhibit negligible absorption of free-space broadband pump light. Recently, this limitation was lifted by cascade energy transfer, in which the absorption and quality factor are modulated with wavelength, enabling non-resonant pumping of high-quality micro-lasers and solar-pumped laser to operate at record low solar concentration. Here, we present a generic theoretical framework for modeling the absorption, emission and energy transfer of incoherent radiation between cascade sensitizer and laser gain media. Our model is based on linear equations of the modified net radiation method and is therefore robust, fast converging and has low complexity. We apply this formalism to compute the optimal parameters of low-threshold solar-pumped lasers. It is revealed that the interplay between the absorption and self-absorption of such lasers defines the optimal pump absorption below the maximal value, which is in contrast to conventional lasers for which full pump absorption is desired. Numerical results are compared to experimental data on a sensitized Nd3+:YAG cavity, and quantitative agreement with theoretical models is found. Our work modularizes the gain and sensitizing components and paves the way for the optimal design of broadband-pumped high-quality micro-lasers and efficient solar-pumped lasers. PMID:27924844

  15. Design and evaluation of area-efficient and wide-range impedance analysis circuit for multichannel high-quality brain signal recording system

    NASA Astrophysics Data System (ADS)

    Iwagami, Takuma; Tani, Takaharu; Ito, Keita; Nishino, Satoru; Harashima, Takuya; Kino, Hisashi; Kiyoyama, Koji; Tanaka, Tetsu

    2016-04-01

    To enable chronic and stable neural recording, we have been developing an implantable multichannel neural recording system with impedance analysis functions. One of the important things for high-quality neural signal recording is to maintain well interfaces between recording electrodes and tissues. We have proposed an impedance analysis circuit with a very small circuit area, which is implemented in a multichannel neural recording and stimulating system. In this paper, we focused on the design of an impedance analysis circuit configuration and the evaluation of a minimal voltage measurement unit. The proposed circuit has a very small circuit area of 0.23 mm2 designed with 0.18 µm CMOS technology and can measure interface impedances between recording electrodes and tissues in ultrawide ranges from 100 Ω to 10 MΩ. In addition, we also successfully acquired interface impedances using the proposed circuit in agarose gel experiments.

  16. Short time synthesis of high quality carbon nanotubes with high rates by CVD of methane on continuously emerged iron nanoparticles

    NASA Astrophysics Data System (ADS)

    Bahrami, Behnam; Khodadadi, Abasali; Mortazavi, Yadollah; Esmaieli, Mohamad

    2011-09-01

    We report the variation of yield and quality of carbon nanotubes (CNTs) grown by chemical vapor deposition (CVD) of methane on iron oxide-MgO at 900-1000 °C for 1-60 min. The catalyst was prepared by impregnation of MgO powder with iron nitrate, dried, and calcined at 300 °C. As calcined and unreduced catalyst in quartz reactor was brought to the synthesis temperature in helium flow in a few minutes, and then the flow was switched to methane. The iron oxide was reduced to iron nanoparticles in methane, while the CNTs were growing. TEM micrographs, in accordance with Raman RBM peaks, indicate the formation of mostly single wall carbon nanotubes of about 1.0 nm size. High quality CNTs with IG/ID Raman peak ratio of 14.5 are formed in the first minute of CNTs synthesis with the highest rate. Both the rate and quality of CNTs degrades with increasing CNTs synthesis time. Also CNTs quality sharply declines with temperature in the range of 900-1000 °C, while the CNTs yield passes through a maximum at 950 °C. About the same CNTs lengths are formed for the whole range of the synthesis times. A model of continuous emergence of iron nanoparticle seeds for CNTs synthesis may explain the data. The data can also provide information for continuous production of CNTs in a fluidized bed reactor.

  17. High quality thin films of thermoelectric misfit cobalt oxides prepared by a chemical solution method

    NASA Astrophysics Data System (ADS)

    Rivas-Murias, Beatriz; Manuel Vila-Fungueiriño, José; Rivadulla, Francisco

    2015-07-01

    Misfit cobaltates ([Bi/Ba/Sr/Ca/CoO]nRS[CoO2]q) constitute the most promising family of thermoelectric oxides for high temperature energy harvesting. However, their complex structure and chemical composition makes extremely challenging their deposition by high-vacuum physical techniques. Therefore, many of them have not been prepared as thin films until now. Here we report the synthesis of high-quality epitaxial thin films of the most representative members of this family of compounds by a water-based chemical solution deposition method. The films show an exceptional crystalline quality, with an electrical conductivity and thermopower comparable to single crystals. These properties are linked to the epitaxial matching of the rock-salt layers of the structure to the substrate, producing clean interfaces free of amorphous phases. This is an important step forward for the integration of these materials with complementary n-type thermoelectric oxides in multilayer nanostructures.

  18. Large, high quality single-crystals of the new Topological Kondo Insulator, SmB6

    PubMed Central

    Hatnean, M. Ciomaga; Lees, M. R.; Paul, D. M. K.; Balakrishnan, G.

    2013-01-01

    SmB6 has recently been predicted to be a Topological Kondo Insulator, the first strongly correlated heavy fermion material to exhibit topological surface states. High quality crystals are necessary to investigate the topological properties of this material. Single crystal growth of the rare earth hexaboride, SmB6, has been carried out by the floating zone technique using a high power xenon arc lamp image furnace. Large, high quality single-crystals are obtained by this technique. The crystals produced by the floating zone technique are free of contamination from flux materials and have been characterised by resistivity and magnetisation measurements. These crystals are ideally suited for the investigation of both the surface and bulk properties of SmB6. PMID:24166216

  19. High quality thin films of thermoelectric misfit cobalt oxides prepared by a chemical solution method

    PubMed Central

    Rivas-Murias, Beatriz; Manuel Vila-Fungueiriño, José; Rivadulla, Francisco

    2015-01-01

    Misfit cobaltates ([Bi/Ba/Sr/Ca/CoO]nRS[CoO2]q) constitute the most promising family of thermoelectric oxides for high temperature energy harvesting. However, their complex structure and chemical composition makes extremely challenging their deposition by high-vacuum physical techniques. Therefore, many of them have not been prepared as thin films until now. Here we report the synthesis of high-quality epitaxial thin films of the most representative members of this family of compounds by a water-based chemical solution deposition method. The films show an exceptional crystalline quality, with an electrical conductivity and thermopower comparable to single crystals. These properties are linked to the epitaxial matching of the rock-salt layers of the structure to the substrate, producing clean interfaces free of amorphous phases. This is an important step forward for the integration of these materials with complementary n-type thermoelectric oxides in multilayer nanostructures. PMID:26153533

  20. (-201) β-Gallium oxide substrate for high quality GaN materials

    NASA Astrophysics Data System (ADS)

    Roqan, I. S.; Muhammed, M. M.

    2014-03-01

    (-201) oriented β-Ga2O3 has the potential to be used as a transparent and conductive substrate for GaN-growth. The key advantages of Ga2O3 are its small lattice mismatches (4.7%), appropriate structural, thermal and electrical properties and a competitive price compared to other substrates. Optical characterization show that GaN layers grown on (-201) oriented β-Ga2O3 are dominated by intense bandedge emission with a high luminescence efficiency. Atomic force microscopy studies show a modest threading dislocation density of ~108 cm-2, while complementary Raman spectroscopy indicates that the GaN epilayer is of high quality with slight compressive strain. Room temperature time-findings suggest that the limitation of the photoluminescence lifetime (~500 ps) is due to nonradiative recombination arising from threading dislocation. Therefore, by optimizing the growth conditions, high quality material with significant optical efficiency can be obtained.

  1. High quality factor trapezoidal subwavelength grating waveguide micro-ring resonator

    NASA Astrophysics Data System (ADS)

    Wang, Zheng; Xu, Xiaochuan; Fan, D. L.; Wang, Yaguo; Chen, Ray T.

    2016-03-01

    In recent decades, silicon photonics has attracted intensive research interest in optical communications due to its advantageous compact dimensions and high-volume manufacturability. Particularly, micro-ring resonators on silicon-oninsulator (SOI) platform have been widely exploited as a basic building block for a vast range of applications such as switches, modulators, and sensors. A majority of these applications involve light-matter interaction, which can be substantially enhanced by the high quality factor micro-ring resonators. However, conventional strip waveguide based micro-ring resonators suffer from the intrinsic dilemma in achieving high light confinement and strong light-matter interaction simultaneously. Subwavelength grating (SWG) waveguides, comprised of periodically interleaved high and low refractive index materials with a pitch less than one wavelength, have been demonstrated as a promising alternative. For SWG waveguides built on SOI wafers, the ratio of silicon and cladding materials can be engineered microscopically to achieve desired macroscopic properties. The control of these properties could potentially lead to significant performance improvements compared with conventional micro-ring resonators based photonic devices, such as filters and sensors. However, SWG waveguide based micro-ring resonators (SWGMRs) that have been demonstrated so far can only provide a moderate quality factor (~5600) with a large radius (e.g. 15 μm), which greatly jeopardize the wide spread research efforts in this area. In this paper, we propose to use trapezoidal silicon pillars to reduce the bend loss of SWGMRs to improve the quality factor. For the first time, we experimentally demonstrate the smallest SWGMR (the micro-ring radius equals to 5 μm) with an applicable quality factor as high as 11,500. This approach also can be applied to SWGMRs with larger radii for higher quality factors. We also experimentally demonstrated a 10 μm radius SWGMR that can provide

  2. Fabrication of high-quality single-crystal Cu thin films using radio-frequency sputtering

    PubMed Central

    Lee, Seunghun; Kim, Ji Young; Lee, Tae-Woo; Kim, Won-Kyung; Kim, Bum-Su; Park, Ji Hun; Bae, Jong-Seong; Cho, Yong Chan; Kim, Jungdae; Oh, Min-Wook; Hwang, Cheol Seong; Jeong, Se-Young

    2014-01-01

    Copper (Cu) thin films have been widely used as electrodes and interconnection wires in integrated electronic circuits, and more recently as substrates for the synthesis of graphene. However, the ultra-high vacuum processes required for high-quality Cu film fabrication, such as molecular beam epitaxy (MBE), restricts mass production with low cost. In this work, we demonstrated high-quality Cu thin films using a single-crystal Cu target and radio-frequency (RF) sputtering technique; the resulting film quality was comparable to that produced using MBE, even under unfavorable conditions for pure Cu film growth. The Cu thin film was epitaxially grown on an Al2O3 (sapphire) (0001) substrate, and had high crystalline orientation along the (111) direction. Despite the 10−3 Pa vacuum conditions, the resulting thin film was oxygen free due to the high chemical stability of the sputtered specimen from a single-crystal target; moreover, the deposited film had >5× higher adhesion force than that produced using a polycrystalline target. This fabrication method enabled Cu films to be obtained using a simple, manufacturing-friendly process on a large-area substrate, making our findings relevant for industrial applications. PMID:25169804

  3. Cognitive strategies and quality of life of patients with high-grade glioma.

    PubMed

    Lucchiari, C; Botturi, A; Silvani, A; Lamperti, E; Gaviani, P; Innocenti, A; Finocchiaro, C Y; Masiero, M; Pravettoni, G

    2015-12-01

    The purpose of this study was to analyze the psychological well-being, quality of life, and cognitive strategies activated by patients with high-grade glioma. We hypothesized that the self-perceived quality of life is modulated by physical and psychological factors and that in order to understand this modulation more psychometric approaches are necessary. Data were collected from a sample of 73 consecutive patients with a histological diagnosis of primary malignant brain cancer (grade IV glioblastoma and grade III anaplastic astrocytoma) hospitalized in a specialized Italian center. The Functional Assessment of Cancer Therapy (FACT) scale and the Schedule of Evaluation of Individual Quality of Life-Direct Weighting (SEIQoL-DW) scale were used to assess quality of life. The mean FACT-Brain (Br) score was 122.37. Similarly, the median SEIQoL-DW score was 72.9 out of a maximum value of 100. No gender effect was found in relation to overall quality of life. Patients with high depression and/or anxiety scores reported lower quality of life (QoL) scores in all the instruments considered. We did not find any gender effect concerning depression and anxiety levels. However, we found that men and women, though having similar physical and functional well-being, reported different QoL determinants, since men seem to rely more on physical adjustment, while women activate more introspective strategies. Positive actions, family issues, negative thoughts, health, and positive thoughts were found to be the most reported themes. In conclusion, the present study strongly suggests that a positive psychological adjustment is possible also in the event of a severe diagnosis and during aggressive treatments, but QoL determinants might be considered too in order to help health professionals to understand patients' experience and to meet their needs.

  4. High performance catalytic distillation using CNTs-based holistic catalyst for production of high quality biodiesel

    NASA Astrophysics Data System (ADS)

    Zhang, Dongdong; Wei, Dali; Li, Qi; Ge, Xin; Guo, Xuefeng; Xie, Zaiku; Ding, Weiping

    2014-02-01

    For production of biodiesel from bio oils by heterogeneous catalysis, high performance catalysts of transesterification and the further utilization of glycerol have been the two points of research. The process seemed easy, however, has never been well established. Here we report a novel design of catalytic distillation using hierachically integrated CNTs-based holistic catalyst to figure out the two points in one process, which shows high performance both for the conversion of bio oils to biodiesel and, unexpectedly, for the conversion of glycerol to more valuable chemicals at the same time. The method, with integration of nano, meso to macro reactor, has overwhelming advantages over common technologies using liquid acids or bases to catalyze the reactions, which suffer from the high cost of separation and unsolved utilization of glycerol.

  5. High performance catalytic distillation using CNTs-based holistic catalyst for production of high quality biodiesel

    PubMed Central

    Zhang, Dongdong; Wei, Dali; Li, Qi; Ge, Xin; Guo, Xuefeng; Xie, Zaiku; Ding, Weiping

    2014-01-01

    For production of biodiesel from bio oils by heterogeneous catalysis, high performance catalysts of transesterification and the further utilization of glycerol have been the two points of research. The process seemed easy, however, has never been well established. Here we report a novel design of catalytic distillation using hierachically integrated CNTs-based holistic catalyst to figure out the two points in one process, which shows high performance both for the conversion of bio oils to biodiesel and, unexpectedly, for the conversion of glycerol to more valuable chemicals at the same time. The method, with integration of nano, meso to macro reactor, has overwhelming advantages over common technologies using liquid acids or bases to catalyze the reactions, which suffer from the high cost of separation and unsolved utilization of glycerol. PMID:24503897

  6. Commentary: what if high-quality care drove medical education? A multiattribute approach.

    PubMed

    Sklar, David P; Lee, Robert

    2010-09-01

    The current medical education model is based on the assumption that students progress from a mastery of basic mechanisms of human structure and function to an understanding of a variety of pathologies and treatments using sound scientific principles. In this commentary, the authors suggest another approach to developing medical school curricula. Starting with the major desired outcome of medical education, which they suggest should be high-quality medical care, educators can work backward using the attributes of quality as the basis for developing new medical curricula. The authors present, as an example, the Institute of Medicine definition of quality care--care that is safe, timely, effective, efficient, equitable, and patient-centered. These objectives and their attributes then can be useful for mapping current and future curricula in medical education and identifying deficits or possible excesses. A result of this approach might be the inclusion of such topics as epidemiology, process engineering, or aspects of the humanities or social sciences that build skills and knowledge in patient-centered care or safety while maintaining a balance with the need to preserve biomedical topics. Use of quality objectives and attributes to drive medical education should lead to improved alignment of the clinical and educational missions of academic medical centers, which, in turn, should lead to safer and higher quality care for patients.

  7. Intensive care unit-acquired weakness.

    PubMed

    Horn, J; Hermans, G

    2017-01-01

    When critically ill, a severe weakness of the limbs and respiratory muscles often develops with a prolonged stay in the intensive care unit (ICU), a condition vaguely termed intensive care unit-acquired weakness (ICUAW). Many of these patients have serious nerve and muscle injury. This syndrome is most often seen in surviving critically ill patients with sepsis or extensive inflammatory response which results in increased duration of mechanical ventilation and hospital length of stay. Patients with ICUAW often do not fully recover and the disability will seriously impact on their quality of life. In this chapter we discuss the current knowledge on the pathophysiology and risk factors of ICUAW. Tools to diagnose ICUAW, how to separate ICUAW from other disorders, and which possible treatment strategies can be employed are also described. ICUAW is finally receiving the attention it deserves and the expectation is that it can be better understood and prevented.

  8. A Modified Protocol for High-Quality RNA Extraction from Oleoresin-Producing Adult Pines.

    PubMed

    de Lima, Júlio César; Füller, Thanise Nogueira; de Costa, Fernanda; Rodrigues-Corrêa, Kelly C S; Fett-Neto, Arthur G

    2016-01-01

    RNA extraction resulting in good yields and quality is a fundamental step for the analyses of transcriptomes through high-throughput sequencing technologies, microarray, and also northern blots, RT-PCR, and RTqPCR. Even though many specific protocols designed for plants with high content of secondary metabolites have been developed, these are often expensive, time consuming, and not suitable for a wide range of tissues. Here we present a modification of the method previously described using the commercially available Concert™ Plant RNA Reagent (Invitrogen) buffer for field-grown adult pine trees with high oleoresin content.

  9. High quality factor silica microspheres functionalized with self-assembled nanomaterials.

    PubMed

    Kandas, Ishac; Zhang, Baigang; Daengngam, Chalongrat; Ashry, Islam; Jao, Chih-Yu; Peng, Bo; Ozdemir, Sahin K; Robinson, Hans D; Heflin, James R; Yang, Lan; Xu, Yong

    2013-09-09

    With extremely low material absorption and exceptional surface smoothness, silica-based optical resonators can achieve extremely high cavity quality (Q) factors. However, the intrinsic material limitations of silica (e.g., lack of second order nonlinearity) may limit the potential applications of silica-based high Q resonators. Here we report some results in utilizing layer-by-layer self-assembly to functionalize silica microspheres with nonlinear and plasmonic nanomaterials while maintaining Q factors as high as 10(7). We compare experimentally measured Q factors with theoretical estimates, and find good agreement.

  10. A high quality liquid-type quantum dot white light-emitting diode.

    PubMed

    Sher, Chin-Wei; Lin, Chin-Hao; Lin, Huang-Yu; Lin, Chien-Chung; Huang, Che-Hsuan; Chen, Kuo-Ju; Li, Jie-Ru; Wang, Kuan-Yu; Tu, Hsien-Hao; Fu, Chien-Chung; Kuo, Hao-Chung

    2016-01-14

    This study demonstrates a novel package design to store colloidal quantum dots in liquid format and integrate them with a standard LED. The high efficiency and high quality color performance at a neutral white correlated color temperature is demonstrated. The experimental results indicate that the liquid-type quantum dot white light-emitting diode (LQD WLED) is highly efficient and reliable. The luminous efficiency and color rendering index (CRI) of the LQD WLED can reach 271 lm Wop(-1) and 95, respectively. Moreover, a glass box is employed to prevent humidity and oxygen erosion. With this encapsulation design, our quantum dot box can survive over 1000 hours of storage time.

  11. High-Quality High Schools. "Preparing All Students for Success in Postsecondary Education, Careers and Citizenship"

    ERIC Educational Resources Information Center

    Ohio Department of Education, 2004

    2004-01-01

    For too many Ohio Students, high school does not work. The Task Force's vision for solving this problem is clear. The journey to make this vision a reality-- to ensure that every student graduates with the knowledge and skills he or she needs to succeed in college and the workplace and to be a good and productive citizen --will not be easy. But it…

  12. High Content Screening as High Quality Assay for Biological Evaluation of Photosensitizers In Vitro

    PubMed Central

    Vaz, Gisela M. F.; Paszko, Edyta; Davies, Anthony M.; Senge, Mathias O.

    2013-01-01

    A novel single step assay approach to screen a library of photdynamic therapy (PDT) compounds was developed. Utilizing high content analysis (HCA) technologies several robust cellular parameters were identified, which can be used to determine the phototoxic effects of porphyrin compounds which have been developed as potential anticancer agents directed against esophageal carcinoma. To demonstrate the proof of principle of this approach a small detailed study on five porphyrin based compounds was performed utilizing two relevant esophageal cancer cell lines (OE21 and SKGT-4). The measurable outputs from these early studies were then evaluated by performing a pilot screen using a set of 22 compounds. These data were evaluated and validated by performing comparative studies using a traditional colorimetric assay (MTT). The studies demonstrated that the HCS assay offers significant advantages over and above the currently used methods (directly related to the intracellular presence of the compounds by analysis of their integrated intensity and area within the cells). A high correlation was found between the high content screening (HCS) and MTT data. However, the HCS approach provides additional information that allows a better understanding of the behavior of these compounds when interacting at the cellular level. This is the first step towards an automated high-throughput screening of photosensitizer drug candidates and the beginnings of an integrated and comprehensive quantitative structure action relationship (QSAR) study for photosensitizer libraries. PMID:23923014

  13. Evaluation of methods for the isolation of high quality RNA from bovine and cervine hide biopsies.

    PubMed

    Brannan, Jaime L; Holman, Patricia J; Olafson, Pia U; Pruett, John H; Riggs, Penny K

    2013-02-01

    Molecular investigations of the ruminant response to ectoparasites at the parasite-host interface are critically dependent upon the quality of RNA. The complexity of ruminant skin decreases the capacity to obtain high quality RNA from biopsy samples, which directly affects the reliability of data produced by gene expression experiments. Two methods for isolating total RNA from skin were compared and the use of 4M guanidinium isothiocyanate (GITC) during frozen storage of the specimens was evaluated. In addition, the best procedure for RNA isolation from bovine skin punch biopsies was also tested on white-tailed deer skin biopsies. Skin biopsy punches were collected and frozen prior to pulverization for RNA isolation. Total RNA quantity and integrity were determined by spectrophotometry and capillary electrophoresis technology, respectively. Significantly increased total RNA yield (P < 0.05) and higher integrity (P < 0.05) were obtained with a TRI Reagent® isolation method. Freezing and subsequent storage of bovine skin punch biopsies in 4 M GITC did not affect the amount or integrity of total RNA recovered by either RNA isolation method. However, quantity and integrity of total RNA extracted with the TRI Reagent method were again significantly higher than with the alternate technique, confirming it as the superior method. The TRI Reagent isolation method also yielded high quality total RNA from white-tailed deer skin punch biopsies, suggesting the usefulness of this method for obtaining RNA of a quality suitable for gene expression studies in other ruminant species.

  14. mQC: A Heuristic Quality-Control Metric for High-Throughput Drug Combination Screening

    PubMed Central

    Chen, Lu; Wilson, Kelli; Goldlust, Ian; Mott, Bryan T.; Eastman, Richard; Davis, Mindy I.; Zhang, Xiaohu; McKnight, Crystal; Klumpp-Thomas, Carleen; Shinn, Paul; Simmons, John; Gormally, Mike; Michael, Sam; Thomas, Craig J.; Ferrer, Marc; Guha, Rajarshi

    2016-01-01

    Quality control (QC) metrics are critical in high throughput screening (HTS) platforms to ensure reliability and confidence in assay data and downstream analyses. Most reported HTS QC metrics are designed for plate level or single well level analysis. With the advent of high throughput combination screening there is a need for QC metrics that quantify the quality of combination response matrices. We introduce a predictive, interpretable, matrix-level QC metric, mQC, based on a mix of data-derived and heuristic features. mQC accurately reproduces the expert assessment of combination response quality and correctly identifies unreliable response matrices that can lead to erroneous or misleading characterization of synergy. When combined with the plate-level QC metric, Z’, mQC provides a more appropriate determination of the quality of a drug combination screen. Retrospective analysis on a number of completed combination screens further shows that mQC is able to identify problematic screens whereas plate-level QC was not able to. In conclusion, our data indicates that mQC is a reliable QC filter that can be used to identify problematic drug combinations matrices and prevent further analysis on erroneously active combinations as well as for troubleshooting failed screens. The R source code of mQC is available at http://matrix.ncats.nih.gov/mQC. PMID:27883049

  15. High Adherence Is Necessary to Realize Health Gains from Water Quality Interventions

    PubMed Central

    Brown, Joe; Clasen, Thomas

    2012-01-01

    Background Safe drinking water is critical for health. Household water treatment (HWT) has been recommended for improving access to potable water where existing sources are unsafe. Reports of low adherence to HWT may limit the usefulness of this approach, however. Methods and Findings We constructed a quantitative microbial risk model to predict gains in health attributable to water quality interventions based on a range of assumptions about pre-treatment water quality; treatment effectiveness in reducing bacteria, viruses, and protozoan parasites; adherence to treatment interventions; volume of water consumed per person per day; and other variables. According to mean estimates, greater than 500 DALYs may be averted per 100,000 person-years with increased access to safe water, assuming moderately poor pre-treatment water quality that is a source of risk and high treatment adherence (>90% of water consumed is treated). A decline in adherence from 100% to 90% reduces predicted health gains by up to 96%, with sharpest declines when pre-treatment water quality is of higher risk. Conclusions Results suggest that high adherence is essential in order to realize potential health gains from HWT. PMID:22586491

  16. Ultrafast formation of air-processable and high-quality polymer films on an aqueous substrate

    NASA Astrophysics Data System (ADS)

    Noh, Jonghyeon; Jeong, Seonju; Lee, Jung-Yong

    2016-08-01

    Polymer solar cells are attracting attention as next-generation energy sources. Scalable deposition techniques of high-quality organic films should be guaranteed to realize highly efficient polymer solar cells in large areas for commercial viability. Herein, we introduce an ultrafast, scalable, and versatile process for forming high-quality organic films on an aqueous substrate by utilizing the spontaneous spreading phenomenon. This approach provides easy control over the thickness of the films by tuning the spreading conditions, and the films can be transferred to a variety of secondary substrates. Moreover, the controlled Marangoni flow and ultrafast removal of solvent during the process cause the films to have a uniform, high-quality nanomorphology with finely separated phase domains. Polymer solar cells were fabricated from a mixture of polymer and fullerene derivatives on an aqueous substrate by using the proposed technique, and the device exhibited an excellent power conversion efficiency of 8.44 %. Furthermore, a roll-to-roll production system was proposed as an air-processable and scalable commercial process for fabricating organic devices.

  17. Personality and relationship quality during the transition from high school to early adulthood.

    PubMed

    Parker, Philip D; Lüdtke, Oliver; Trautwein, Ulrich; Roberts, Brent W

    2012-08-01

    The post-high school transition period is believed to be associated with considerable changes in social networks, yet longitudinal studies documenting these changes are scarce. To address this gap, the current research explored 3 relevant issues. First, changes in participants' relationship characteristics during the transition from high school were examined. Second, the roles of personality traits as antecedents of these changes were studied. Third, the association between change in relationship characteristics and personality during the transition was explored. A sample of over 2,000 German emerging adults, surveyed before leaving school and then 2 years after the transition from high school, was assessed on personality traits and a multidimensional assessment of the quality of their relationships. Findings indicated that participants experienced mostly positive changes in relationship quality during the transition from high school and that antecedent personality at school was an important predictor of the nature of this change. Finally, change in relationship quality was found to be associated with personality change during the post-school transition. Findings indicated that personality traits may influence transition success and that change in relationships during this transition may influence personality development. The implications of the research for post-school transition success are discussed.

  18. Ultrafast formation of air-processable and high-quality polymer films on an aqueous substrate

    PubMed Central

    Noh, Jonghyeon; Jeong, Seonju; Lee, Jung-Yong

    2016-01-01

    Polymer solar cells are attracting attention as next-generation energy sources. Scalable deposition techniques of high-quality organic films should be guaranteed to realize highly efficient polymer solar cells in large areas for commercial viability. Herein, we introduce an ultrafast, scalable, and versatile process for forming high-quality organic films on an aqueous substrate by utilizing the spontaneous spreading phenomenon. This approach provides easy control over the thickness of the films by tuning the spreading conditions, and the films can be transferred to a variety of secondary substrates. Moreover, the controlled Marangoni flow and ultrafast removal of solvent during the process cause the films to have a uniform, high-quality nanomorphology with finely separated phase domains. Polymer solar cells were fabricated from a mixture of polymer and fullerene derivatives on an aqueous substrate by using the proposed technique, and the device exhibited an excellent power conversion efficiency of 8.44 %. Furthermore, a roll-to-roll production system was proposed as an air-processable and scalable commercial process for fabricating organic devices. PMID:27507624

  19. Personality and Relationship Quality During the Transition From High School to Early Adulthood

    PubMed Central

    Parker, Philip D.; Lüdtke, Oliver; Trautwein, Ulrich; Roberts, Brent W.

    2013-01-01

    The post–high school transition period is believed to be associated with considerable changes in social networks, yet longitudinal studies documenting these changes are scarce. To address this gap, the current research explored 3 relevant issues. First, changes in participants’ relationship characteristics during the transition from high school were examined. Second, the roles of personality traits as antecedents of these changes were studied. Third, the association between change in relationship characteristics and personality during the transition was explored. A sample of over 2,000 German emerging adults, surveyed before leaving school and then 2 years after the transition from high school, was assessed on personality traits and a multidimensional assessment of the quality of their relationships. Findings indicated that participants experienced mostly positive changes in relationship quality during the transition from high school and that antecedent personality at school was an important predictor of the nature of this change. Finally, change in relationship quality was found to be associated with personality change during the post-school transition. Findings indicated that personality traits may influence transition success and that change in relationships during this transition may influence personality development. The implications of the research for post-school transition success are discussed. PMID:22224909

  20. Fabrication of high quality copper indium disulphide absorbers by bell-like wave modulated electrodeposition

    SciTech Connect

    Cheng, Ke; Wang, Xiaoyun; Liu, Jingjing; Huang, Yuqian; Xue, Ming; Kuang, Zhongcheng; Wan, Shaoming; Du, Zuliang

    2016-04-15

    Highlights: • Cu/In bilayer was fabricated by BMSMW deposition technique. • High quality CIS film was successfully fabricated. • A preferable ratio of Cu:In:S close to 1:1:2 was approached. • The SPV response as high as 6 mV was achieved. - Abstract: High-quality CuInS{sub 2} (CIS) thin films have been fabricated by sulfurization of electrodeposited copper–indium bilayer. A novel bell-like wave modulated square wave (BWMSW) electrodeposition technique is employed for the deposition of copper thin film. Three independent parameters (current or potential, frequency, duty cycle) are available for the BWMSW electrodeposition, which is different from the traditional electrodeposition technique with only one adjustable parameter (current or potential). The influences of deposition parameters such as frequency, duty cycle and the concentration of complexing agent are investigated. Benefited from the high quality copper film obtained by the BWMSW technique, the indium film is electrodeposited successfully on the copper layer to form a compact copper–indium alloy bilayer. After sulfurized at 600 °C for 60 min, the phase pure CIS film is obtained with better crystallinity. The structures, morphologies and optoelectronic properties of the CIS film are also characterized.

  1. High-quality embryos retain their implantation capability in overweight women.

    PubMed

    Farhi, Jacob; Ben-Haroush, Avi; Sapir, Onit; Fisch, Benjamin; Ashkenazi, Jacob

    2010-11-01

    To assess the effect of obesity on implantation rate, pregnancy rate and course of pregnancy in young women undergoing IVF in whom only high-quality embryos were transferred, a cohort study included women attending the IVF unit in 2006-2007 with favourable parameters to achieve pregnancy (<38years, fewer than three IVF cycles, transfer of two high-quality embryos), grouped by body mass index (BMI). Of 230 women, 160 had a BMI ⩽25kg/m(2) (mean 21.6±2.2) and 73 had BMI >25kg/m(2) (mean 29.5±3.7). The overweight group had a higher consumption of gonadotrophins during stimulation. There were no between-group differences in treatment protocols, duration of gonadotrophin stimulation, maximal oestradiol concentrations, endometrial thickness and number of oocytes retrieved/fertilized, or in rates of pregnancy (51.3%, 52.1%), implantation (34.5%, 37.5%), multiple pregnancy, and abortion. Rate of gestational diabetes or pregnancy-induced hypertension was higher in the overweight group (23.3%, 8.2%; P=0.045). Within the overweight group, those with multiple pregnancies were at highest risk (31.3%, 6.9%; P=0.031). In conclusion, implantation and pregnancy rates are not compromised in overweight women when high-quality embryos are transferred. However, in overweight women, pregnancy complications remain high, mainly in those with multiple pregnancies.

  2. Electrical behavior of atomic layer deposited high quality SiO{sub 2} gate dielectric

    SciTech Connect

    Pradhan, Sangram K.; Tanyi, Ekembu K.; Skuza, Jonathan R.; Xiao, Bo; Pradhan, Aswini K.

    2015-01-01

    Comprehensive and systematic electrical studies were performed on fabrication of high quality SiO{sub 2} thin films MOS capacitor using the robust, novel, and simple atomic layer deposition (ALD) technique using highly reactive ozone and tris (dimethylamino) silane (TDMAS) precursors. Ideal capacitance–voltage curve exhibits a very small frequency dispersion and hysteresis behavior of the SiO{sub 2} MOS capacitor grown at 1 s TDMAS pulse, suggesting excellent interfacial quality and purity of the film as probed using x-ray photoelectron studies. The flat-band voltage of the device shifted from negative toward positive voltage axis with increase of TDMAS pulses from 0.2 to 2 s. Based on an equivalent oxide thickness point of view, all SiO{sub 2} films have gate leakage current density of (5.18 × 10{sup −8} A/cm{sup 2}) as well as high dielectric break down fields of more than (∼10 MV/cm), which is better and comparable to that of thermally grown SiO{sub 2} at temperatures above 800 °C. These appealing electrical properties of ALD grown SiO{sub 2} thin films enable its potential applications such as high-quality gate insulators for thin film MOS transistors, as well as insulators for sensor and nanostructures on nonsilicon substrates.

  3. Effect of high hydrostatic pressure on overall quality parameters of watermelon juice.

    PubMed

    Liu, Y; Zhao, X Y; Zou, L; Hu, X S

    2013-06-01

    High hydrostatic pressure as a kind of non-thermal processing might maintain the quality of thermo-sensitive watermelon juice. So, the effect of high hydrostatic pressure treatment on enzymes and quality of watermelon juice was investigated. After high hydrostatic pressure treatment, the activities of polyphenol oxidase, peroxidase, and pectin methylesterase of juice decreased significantly with the pressure (P < 0.05). Inactivation of polyphenol oxidase and peroxidase could be fitted by two-fraction model and that of pectin methylesterase could be described by first-order reaction model. Titratable acidity, pH, and total soluble solid of juice did not change significantly (P > 0.05). No significant difference was observed in lycopene and total phenolics after high hydrostatic pressure treatment when compared to the control (P > 0.05). Cloudiness and viscosity increased with pressure (P < 0.05) but did not change significantly with treatment time (P > 0.05). a*- and b*-value both unchanged after high hydrostatic pressure treatment (P > 0.05) while L*-value increased but the values had no significant difference among treated juices. Browning degree after high hydrostatic pressure treatment decreased with increase in pressure and treatment time (P < 0.05). Through the comparison of total color difference values, high hydrostatic pressure had little effect on color of juice. The results of this study demonstrated the efficacy of high hydrostatic pressure in inactivating enzymes and maintaining the quality of watermelon juice.

  4. Fundamental properties of high-quality carbon nanofoam: from low to high density

    PubMed Central

    Frese, Natalie; Taylor Mitchell, Shelby; Neumann, Christof; Bowers, Amanda; Gölzhäuser, Armin

    2016-01-01

    Highly uniform samples of carbon nanofoam from hydrothermal sucrose carbonization were studied by helium ion microscopy (HIM), X-ray photoelectron spectroscopy (XPS), and Raman spectroscopy. Foams with different densities were produced by changing the process temperature in the autoclave reactor. This work illustrates how the geometrical structure, electron core levels, and the vibrational signatures change when the density of the foams is varied. We find that the low-density foams have very uniform structure consisting of micropearls with ≈2–3 μm average diameter. Higher density foams contain larger-sized micropearls (≈6–9 μm diameter) which often coalesced to form nonspherical μm-sized units. Both, low- and high-density foams are comprised of predominantly sp2-type carbon. The higher density foams, however, show an advanced graphitization degree and a stronger sp3-type electronic contribution, related to the inclusion of sp3 connections in their surface network. PMID:28144554

  5. Fundamental properties of high-quality carbon nanofoam: from low to high density.

    PubMed

    Frese, Natalie; Taylor Mitchell, Shelby; Neumann, Christof; Bowers, Amanda; Gölzhäuser, Armin; Sattler, Klaus

    2016-01-01

    Highly uniform samples of carbon nanofoam from hydrothermal sucrose carbonization were studied by helium ion microscopy (HIM), X-ray photoelectron spectroscopy (XPS), and Raman spectroscopy. Foams with different densities were produced by changing the process temperature in the autoclave reactor. This work illustrates how the geometrical structure, electron core levels, and the vibrational signatures change when the density of the foams is varied. We find that the low-density foams have very uniform structure consisting of micropearls with ≈2-3 μm average diameter. Higher density foams contain larger-sized micropearls (≈6-9 μm diameter) which often coalesced to form nonspherical μm-sized units. Both, low- and high-density foams are comprised of predominantly sp(2)-type carbon. The higher density foams, however, show an advanced graphitization degree and a stronger sp(3)-type electronic contribution, related to the inclusion of sp(3) connections in their surface network.

  6. Genetic variation for agronomic and fiber quality traits in a population derived from high-quality cotton germplasm

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Genetic improvement of fiber quality is necessary to meet the requirements of processors and users of cotton fiber. To foster genetic improvement of cotton fiber quality, adequate genetic variation for the quantitatively inherited physical properties of cotton is required. Additionally, knowledge of...

  7. Acquired Upper Extremity Growth Arrest.

    PubMed

    Gauger, Erich M; Casnovsky, Lauren L; Gauger, Erica J; Bohn, Deborah C; Van Heest, Ann E

    2016-09-29

    This study reviewed the clinical history and management of acquired growth arrest in the upper extremity in pediatric patients. The records of all patients presenting from 1996 to 2012 with radiographically proven acquired growth arrest were reviewed. Records were examined to determine the etiology and site of growth arrest, management, and complications. Patients with tumors or hereditary etiology were excluded. A total of 44 patients (24 boys and 20 girls) with 51 physeal arrests who presented at a mean age of 10.6 years (range, 0.8-18.2 years) were included in the study. The distal radius was the most common site (n=24), followed by the distal humerus (n=8), metacarpal (n=6), distal ulna (n=5), proximal humerus (n=4), radial head (n=3), and olecranon (n=1). Growth arrest was secondary to trauma (n=22), infection (n=11), idiopathy (n=6), inflammation (n=2), compartment syndrome (n=2), and avascular necrosis (n=1). Twenty-six patients (59%) underwent surgical intervention to address deformity caused by the physeal arrest. Operative procedures included ipsilateral unaffected bone epiphysiodesis (n=21), shortening osteotomy (n=10), lengthening osteotomy (n=8), excision of physeal bar or bone fragment (n=2), angular correction osteotomy (n=1), and creation of single bone forearm (n=1). Four complications occurred; 3 of these required additional procedures. Acquired upper extremity growth arrest usually is caused by trauma or infection, and the most frequent site is the distal radius. Growth disturbances due to premature arrest can be treated effectively with epiphysiodesis or osteotomy. In this series, the specific site of anatomic growth arrest was the primary factor in determining treatment. [Orthopedics. 201x; xx(x):xx-xx.].

  8. The inhibition of acquired fear.

    PubMed

    Izquierdo, Iván; Cammarota, Martín; Vianna, Mónica M R; Bevilaqua, Lía R M

    2004-01-01

    A conditioned stimulus (CS) associated with a fearsome unconditioned stimulus (US) generates learned fear. Acquired fear is at the root of a variety of mental disorders, among which phobias, generalized anxiety, the posttraumatic stress disorder (PTSD) and some forms of depression. The simplest way to inhibit learned fear is to extinguish it, which is usually done by repeatedly presenting the CS alone, so that a new association, CS-"no US", will eventually overcome the previously acquired CS-US association. Extinction was first described by Pavlov as a form of "internal inhibition" and was recommended by Freud and Ferenczi in the 1920s (who called it "habituation") as the treatment of choice for phobic disorders. It is used with success till this day, often in association with anxiolytic drugs. Extinction has since then been applied, also successfully and also often in association with anxiolytics, to the treatment of panic, generalized anxiety disorders and, more recently, PTSD. Extinction of learned fear involves gene expression, protein synthesis, N-methyl-D-aspartate (NMDA) receptors and signaling pathways in the hippocampus and the amygdala at the time of the first CS-no US association. It can be enhanced by increasing the exposure to the "no US" component at the time of behavioral testing, to the point of causing the complete uninstallment of the original fear response. Some theorists have recently proposed that reiteration of the CS alone may induce a reconsolidation of the learned behavior instead of its extinction. Reconsolidation would preserve the original memory from the labilization induced by its retrieval. If true, this would of course be disastrous for the psychotherapy of fear-motivated disorders. Here we show that neither the CS nor retrieval cause anything remotely like reconsolidation, but just extinction. In fact, our findings indicate that the reconsolidation hypothesis is essentially incorrect, at least for the form of contextual fear most

  9. Aerodynamic and engineering design of a 1.5 s high quality microgravity drop tower facility

    NASA Astrophysics Data System (ADS)

    Belser, Valentin; Breuninger, Jakob; Reilly, Matthew; Laufer, René; Dropmann, Michael; Herdrich, Georg; Hyde, Truell; Röser, Hans-Peter; Fasoulas, Stefanos

    2016-12-01

    Microgravity experiments are essential for research in space science, biology, fluid mechanics, combustion, and material sciences. One way to conduct microgravity experiments on Earth is by using drop tower facilities. These facilities combine a high quality of microgravity, adequate payload masses and have the advantage of virtually unlimited repeatability under same experimental conditions, at a low cost. In a collaboration between the Institute of Space Systems (IRS) at the University of Stuttgart and Baylor University (BU) in Waco, Texas, a new drop tower is currently under development at the Center for Astrophysics, Space Physics and Engineering Research (CASPER). The design parameters of the drop tower ask for at least 1.5 s in free fall duration while providing a quality of at least 10-5 g. Previously, this quality has only been achieved in vacuum drop tower facilities where the capsule experiences virtually zero aerodynamic drag during its free fall. Since this design comes at high costs, a different drop tower design concept, which does not require an evacuated drop shaft, was chosen. It features a dual-capsule system in which the experiment capsule is shielded from aerodynamic forces by surrounding it with a drag shield during the drop. As no other dual-capsule drop tower has been able to achieve a quality as good as or better than 10-5 g previous work optimized the design with an aerodynamic perspective by using computational fluid dynamics (CFD) simulations to determine the ideal shape and size of the outer capsule and to specify the aerodynamically crucial dimensions for the overall system. Experiments later demonstrated that the required quality of microgravity can be met with the proposed design. The main focus of this paper is the mechanical realization of the capsule as well as the development and layout of the surrounding components, such as the release mechanism, the deceleration device and the drop shaft. Because the drop tower facility is a

  10. A Portable Low-Cost High Density Sensor Network for Air Quality at London Heathrow Airport

    NASA Astrophysics Data System (ADS)

    Popoola, Olalekan; Mead, Iq; Bright, Vivien; Baron, Ronan; Saffell, John; Stewart, Gregor; Kaye, Paul; Jones, Roderic

    2013-04-01

    Outdoor air quality and its impact on human health and the environment have been well studied and it has been projected that poor air quality will surpass poor sanitation as the major course of environmental premature mortality by 2050 (IGAC / IGBP, release statement, 2012). Transport-related pollution has been regulated at various levels by enactment of legislations at local, national, regional and global stages. As part of the mitigation measures, routine measurements of atmospheric pollutants such as carbon monoxide (CO), nitric oxide (NO) and nitrogen dioxide (NO2) have to be established in areas where air quality problems are identified. In addition, emission inventories are also generated for different atmospheric environments including urban areas and airport environments required for air quality models. Whilst recognising that most of the existing sparse monitoring networks provide high temporal measurements, spatial data of these highly variable pollutants are not captured, making it difficult to adequately characterise the highly heterogeneous air quality. Spatial information is often obtained from model data which can only be constrained using measurements from the sparse monitoring networks. The work presented here shows the application of low-cost sensor networks aimed at addressing this missing spatial information. We have shown in previous studies the application of low-cost electrochemical sensor network instruments in monitoring road transport pollutants including CO, NO and NO2 in an urban environment (Mead et. al. 2012, accepted Atmospheric Environment). Modified versions of these instruments which include additional species such as O3, SO2, VOCs and CO2 are currently deployed at London Heathrow Airport (LHR) as part of the Sensor Network for Air Quality (SNAQ) project. Meteorology data such as temperature, relative humidity, wind speed and direction are also measured as well as size-speciated particulates (0.38 to 17.4 µm). A network of 50

  11. Quality considerations with high pressure processing of fresh and value added meat products.

    PubMed

    Bajovic, Bajo; Bolumar, Tomas; Heinz, Volker

    2012-11-01

    Pressure can be applied by high hydrostatic pressure, better known as high pressure processing (HPP), or by hydrodynamic pressure (HDP) in the form of shockwaves to alter quality parameters, such as shelf-life and texture of meat and meat products. The aim of this review is to give an overview of the use of pressure in the meat industry and to highlight its usage as a method to inactivate microorganisms but also a novel strategy to alter the structure and the quality parameters of meat and meat products. Benefits and possibilities of the technologies are presented, as well as how to overcome undesired product changes caused by HPP. The use of hydrodynamic shockwaves is briefly described and a promising newly developed industrial prototype for the generation of shockwaves by underwater explosion is presented.

  12. Sequencing strategy for the whole mitochondrial genome resulting in high quality sequences

    PubMed Central

    Fendt, Liane; Zimmermann, Bettina; Daniaux, Martin; Parson, Walther

    2009-01-01

    Background It has been demonstrated that a reliable and fail-safe sequencing strategy is mandatory for high-quality analysis of mitochondrial (mt) DNA, as the sequencing and base-calling process is prone to error. Here, we present a high quality, reliable and easy handling manual procedure for the sequencing of full mt genomes that is also appropriate for laboratories where fully automated processes are not available. Results We amplified whole mitochondrial genomes as two overlapping PCR-fragments comprising each about 8500 bases in length. We developed a set of 96 primers that can be applied to a (manual) 96 well-based technology, which resulted in at least double strand sequence coverage of the entire coding region (codR). Conclusion This elaborated sequencing strategy is straightforward and allows for an unambiguous sequence analysis and interpretation including sometimes challenging phenomena such as point and length heteroplasmy that are relevant for the investigation of forensic and clinical samples. PMID:19331681

  13. Extraction of high-quality genomic DNA from latex-containing plants.

    PubMed

    Michiels, An; Van den Ende, Wim; Tucker, Mark; Van Riet, Liesbet; Van Laere, André

    2003-04-01

    The isolation of intact, high-molecular-mass genomic DNA is essential for many molecular biology applications including long PCR, endonuclease restriction digestion, Southern blot analysis, and genomic library construction. Many protocols are available for the extraction of DNA from plant material. However, for latex-containing Asteraceae (Cichorioideae) species, standard protocols and commercially available kits do not produce efficient yields of high-quality amplifiable DNA. A cetyltrimethylammonium bromide protocol has been optimized for isolation of genomic DNA from latex-containing plants. Key steps in the modified protocol are the use of etiolated leaf tissue for extraction and an overnight 25 degrees C isopropanol precipitation step. The purified DNA has excellent spectral qualities, is efficiently digested by restriction endonucleases, and is suitable for long-fragment PCR amplification.

  14. A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project

    PubMed Central

    Carithers, Latarsha J.; Ardlie, Kristin; Barcus, Mary; Branton, Philip A.; Britton, Angela; Buia, Stephen A.; Compton, Carolyn C.; DeLuca, David S.; Peter-Demchok, Joanne; Gelfand, Ellen T.; Guan, Ping; Korzeniewski, Greg E.; Lockhart, Nicole C.; Rabiner, Chana A.; Rao, Abhi K.; Robinson, Karna L.; Roche, Nancy V.; Sawyer, Sherilyn J.; Segrè, Ayellet V.; Shive, Charles E.; Smith, Anna M.; Sobin, Leslie H.; Undale, Anita H.; Valentino, Kimberly M.; Vaught, Jim; Young, Taylor R.

    2015-01-01

    The Genotype-Tissue Expression (GTEx) project, sponsored by the NIH Common Fund, was established to study the correlation between human genetic variation and tissue-specific gene expression in non-diseased individuals. A significant challenge was the collection of high-quality biospecimens for extensive genomic analyses. Here we describe how a successful infrastructure for biospecimen procurement was developed and implemented by multiple research partners to support the prospective collection, annotation, and distribution of blood, tissues, and cell lines for the GTEx project. Other research projects can follow this model and form beneficial partnerships with rapid autopsy and organ procurement organizations to collect high quality biospecimens and associated clinical data for genomic studies. Biospecimens, clinical and genomic data, and Standard Operating Procedures guiding biospecimen collection for the GTEx project are available to the research community. PMID:26484571

  15. Effect of extremely low frequency electromagnetic field exposure on sleep quality in high voltage substations

    PubMed Central

    2012-01-01

    This study aims to investigate the effect of extremely low frequency electromagnetic fields exposure on sleep quality in high voltage substations (132, 230 and 400 KV) in Kerman city and the suburbs. For this purpose, the electric field intensity and magnetic flux density were measured in different parts of substations, and then the occupational exposure was estimated by averaging electric field intensity and magnetic flux density in a shift work. The cases comprised 67 workers who had been exposed to electromagnetic fields in age range of 24–57 and the controls were 110 persons the age ranged 24–50 years. Sleep quality of both groups was evaluated by the Pittsburgh Sleep Quality Index questionnaire (PSQI). Finally, these data were subjected to statistical analysis. The results indicated that 90.5% of cases and 85.3% of controls had the poor quality sleep according to PSQI (P-value=0.615). Total sleep quality score mean for the case and control groups were 10.22 ± 3.4 and 9.74 ± 3.62 (P-value=0.415) ,respectively. Meantime to fall asleep for cases(35.68 ± 26.25 min) was significantly higher than for controls (28.89 ± 20.18 min) (P-value=0.002). Cases had average sleep duration of 5.49 ± 1.31 hours, which was lower ascompared with control subjects (5.90 ± 1.67hours). Although there was a higher percentage for the case group with poor sleep quality than the control group, but no statistically significant difference was observed. PMID:23369281

  16. High quality planar silicon nitride microdisk resonators for integrated photonics in the visible wavelength range.

    PubMed

    Hosseini, Ehsan Shah; Yegnanarayanan, Siva; Atabaki, Amir Hossein; Soltani, Mohammad; Adibi, Ali

    2009-08-17

    High quality factor (Q approximately 3.4 x 10(6)) microdisk resonators are demonstrated in a Si(3)N(4) on SiO(2) platform at 652-660 nm with integrated in-plane coupling waveguides. Critical coupling to several radial modes is demonstrated using a rib-like structure with a thin Si(3)N(4) layer at the air-substrate interface to improve the coupling.

  17. High-Quality TiS2 For Li/TiS2 Cells

    NASA Technical Reports Server (NTRS)

    Huang, Chen-Kuo; Surampudi, Subbarao; Shen, David H.; Delgiannis, Fotios; Halpert, Gerald

    1992-01-01

    Modified process for synthesis of battery-grade titanium sulfide (TiS2) yields substantially improved material for Li/TiS2 electrochemical cells. Includes all-vapor-phase reaction between sulfur and titanium. Product less dense and more homogeneous, consists of smaller particles of higher crystalline quality, and purer. Cells have high cathode utilization and long cycle life performance. Expected to find applications in rechargeable lithium batteries for spacecraft, military equipment, telecommunication systems, automobiles, and consumer products.

  18. Neglecting rice milling yield and quality underestimates economic losses from high-temperature stress.

    PubMed

    Lyman, Nathaniel B; Jagadish, Krishna S V; Nalley, L Lanier; Dixon, Bruce L; Siebenmorgen, Terry

    2013-01-01

    Future increases in global surface temperature threaten those worldwide who depend on rice production for their livelihoods and food security. Past analyses of high-temperature stress on rice production have focused on paddy yield and have failed to account for the detrimental impact of high temperatures on milling quality outcomes, which ultimately determine edible (marketable) rice yield and market value. Using genotype specific rice yield and milling quality data on six common rice varieties from Arkansas, USA, combined with on-site, half-hourly and daily temperature observations, we show a nonlinear effect of high-temperature stress exposure on yield and milling quality. A 1 °C increase in average growing season temperature reduces paddy yield by 6.2%, total milled rice yield by 7.1% to 8.0%, head rice yield by 9.0% to 13.8%, and total milling revenue by 8.1% to 11.0%, across genotypes. Our results indicate that failure to account for changes in milling quality leads to understatement of the impacts of high temperatures on rice production outcomes. These dramatic losses result from reduced paddy yield and increased percentages of chalky and broken kernels, which together decrease the quantity and market value of milled rice. Recently published estimates show paddy yield reductions of up to 10% across the major rice-producing regions of South and Southeast Asia due to rising temperatures. The results of our study suggest that the often-cited 10% figure underestimates the economic implications of climate change for rice producers, thus potentially threatening future food security for global rice producers and consumers.

  19. How to conduct clinical research studies using high quality-clinical databases in the critical care.

    PubMed

    Francais, Adrien; Vesin, Aurélien; Timsit, Jean-François

    2008-09-01

    The sources of intensive care-related information and the means of communication increase rapidly. We presented here an overview of what should be done to collect high quality database. In a second part, the principle of the choice of the research question, the outcome, the explanatory variables and the statistical methods to address the question are overviewed, emphasizing major and frequent pitfalls which should be avoided.

  20. ISHTAR: an architecture for a high-quality electronic catalog on the Internet

    NASA Astrophysics Data System (ADS)

    De Sabbata, Piero; Zuffi, Silvia; Correia, Ana Isabel; Benatti, Gianpaolo; Fantin, Sergio

    1999-12-01

    This paper present the results of the activities concerning the architecture of a high quality catalogue for made-to- measure garments undertaken in the ISHTAR project. The syste is based upon servers and standard Internet browsers. The main issues faced in this paper are the definition of an architecture to obtain the best trade off between performance and representation of apparel/textile goods and the introduction of a color management system that can benefit also generic internet users.