Science.gov

Sample records for acquisition protein hasa

  1. HASA: Hypersonic Aerospace Sizing Analysis for the Preliminary Design of Aerospace Vehicles

    NASA Technical Reports Server (NTRS)

    Harloff, Gary J.; Berkowitz, Brian M.

    1988-01-01

    A review of the hypersonic literature indicated that a general weight and sizing analysis was not available for hypersonic orbital, transport, and fighter vehicles. The objective here is to develop such a method for the preliminary design of aerospace vehicles. This report describes the developed methodology and provides examples to illustrate the model, entitled the Hypersonic Aerospace Sizing Analysis (HASA). It can be used to predict the size and weight of hypersonic single-stage and two-stage-to-orbit vehicles and transports, and is also relevant for supersonic transports. HASA is a sizing analysis that determines vehicle length and volume, consistent with body, fuel, structural, and payload weights. The vehicle component weights are obtained from statistical equations for the body, wing, tail, thermal protection system, landing gear, thrust structure, engine, fuel tank, hydraulic system, avionics, electral system, equipment payload, and propellant. Sample size and weight predictions are given for the Space Shuttle orbiter and other proposed vehicles, including four hypersonic transports, a Mach 6 fighter, a supersonic transport (SST), a single-stage-to-orbit (SSTO) vehicle, a two-stage Space Shuttle with a booster and an orbiter, and two methane-fueled vehicles.

  2. Real-Time Protein Crystallization Image Acquisition and Classification System.

    PubMed

    Sigdel, Madhav; Pusey, Marc L; Aygun, Ramazan S

    2013-07-03

    In this paper, we describe the design and implementation of a stand-alone real-time system for protein crystallization image acquisition and classification with a goal to assist crystallographers in scoring crystallization trials. In-house assembled fluorescence microscopy system is built for image acquisition. The images are classified into three categories as non-crystals, likely leads, and crystals. Image classification consists of two main steps - image feature extraction and application of classification based on multilayer perceptron (MLP) neural networks. Our feature extraction involves applying multiple thresholding techniques, identifying high intensity regions (blobs), and generating intensity and blob features to obtain a 45-dimensional feature vector per image. To reduce the risk of missing crystals, we introduce a max-class ensemble classifier which applies multiple classifiers and chooses the highest score (or class). We performed our experiments on 2250 images consisting 67% non-crystal, 18% likely leads, and 15% clear crystal images and tested our results using 10-fold cross validation. Our results demonstrate that the method is very efficient (< 3 seconds to process and classify an image) and has comparatively high accuracy. Our system only misses 1.2% of the crystals (classified as non-crystals) most likely due to low illumination or out of focus image capture and has an overall accuracy of 88%.

  3. Sequential protein NMR assignments in the liquid state via sequential data acquisition

    NASA Astrophysics Data System (ADS)

    Wiedemann, Christoph; Bellstedt, Peter; Kirschstein, Anika; Häfner, Sabine; Herbst, Christian; Görlach, Matthias; Ramachandran, Ramadurai

    2014-02-01

    Two different NMR pulse schemes involving sequential 1H data acquisition are presented for achieving protein backbone sequential resonance assignments: (i) acquisition of 3D {HCCNH and HNCACONH} and (ii) collection of 3D {HNCOCANH and HNCACONH} chemical shift correlation spectra using uniformly 13C,15N labelled proteins. The sequential acquisition of these spectra reduces the overall experimental time by a factor of ≈2 as compared to individual acquisitions. The suitability of this approach is experimentally demonstrated for the C-terminal winged helix (WH) domain of the minichromosome maintenance (MCM) complex of Sulfolobus solfataricus.

  4. 3D stratigraphic forward modelling of Shu'aiba Platform stratigraphy in the Bu Hasa Field, Abu Dhabi, United Arab Emirates.

    NASA Astrophysics Data System (ADS)

    Hu, J.; Lokier, S. W.

    2012-04-01

    This paper presents the results of three dimensional sequence stratigraphic forward modelling of the Aptian age Shu'aiba Formation from Abu Dhabi, United Arab Emirates (UAE). The Shu'aiba Formation lies within the uppermost part of the Lower Cretaceous Thamama Group and forms one of the most prolific hydrocarbon reservoir intervals of the Middle East with production dating back to the 1960's. The Shu'aiba Formation developed as a series of laterally-extensive shallow-water carbonate platforms in an epeiric sea that extended over the northern margin of the African-Arabian Plate. This shallow sea was bounded by the Arabian Shield to the west and the passive margin with the Neo-Tethys Ocean towards the north and east (Droste, 2010). The exposed Arabian Shield acted as a source of siliciclastic sediments to westernmost regions, however, more offshore areas were dominated by shallow-water carbonate deposition. Carbonate production was variously dominated by Lithocodium-Baccinella, orbitolinid foraminifera and rudist bivalves depending on local conditions. While there have been numerous studies of this important stratigraphic interval (for examples see van Buchem et al., 2010), there has been little attempt to simulate the sequence stratigraphic development of the formation. During the present study modelling was undertaken utilising the CARBONATE-3D stratigraphic forward modelling software (Warrlich et al., 2008; Warrlich et al., 2002)) thus allowing for the control of a diverse range of internal and external parameters on carbonate sequence development. This study focuses on platform development in the onshore Bu Hasa Field - the first giant oilfield to produce from the Shu'aiba Formation in Abu Dhabi. The carbonates of the Bu Hasa field were deposited on the southwest slope of the intra-shelf Bab Basin, siliciclastic content is minor. Initially these carbonates were algal dominated with rudist mounds becoming increasingly important over time (Alsharhan, 1987

  5. Flavivirus NS1 protein in infected host sera enhances viral acquisition by mosquitoes

    PubMed Central

    Liu, Jianying; Liu, Yang; Nie, Kaixiao; Du, Senyan; Qiu, Jingjun; Pang, Xiaojing; Wang, Penghua; Cheng, Gong

    2016-01-01

    Summary The arbovirus life cycle involves viral transfer between a vertebrate host and an arthropod vector, and acquisition of virus from an infected mammalian host by a vector is an essential step in this process. Here, we report that flavivirus nonstructural protein-1 (NS1), which is abundantly secreted into the serum of an infected host, plays a critical role in flavivirus acquisition by mosquitoes. The presence of dengue virus (DENV) and Japanese encephalitis virus (JEV) NS1s in the blood of infected interferon alpha and gamma receptor-deficient mice (AG6) facilitated virus acquisition by their native mosquito vectors because the protein enabled the virus to overcome the immune barrier of the mosquito midgut. Active immunization of AG6 mice with a modified DENV NS1 reduced DENV acquisition by mosquitoes and protected mice against a lethal DENV challenge, suggesting that immunization with NS1 could reduce the number of virus-carrying mosquitoes as well as the incidence of flaviviral diseases. Our study demonstrates that flaviviruses utilize NS1 proteins produced during their vertebrate phases to enhance their acquisition by vectors, which might be a result of flavivirus evolution to adapt to multiple host environments. PMID:27562253

  6. Influence of cobalamin scarcity on diatom molecular physiology and identification of a cobalamin acquisition protein.

    PubMed

    Bertrand, Erin M; Allen, Andrew E; Dupont, Christopher L; Norden-Krichmar, Trina M; Bai, Jing; Valas, Ruben E; Saito, Mak A

    2012-06-26

    Diatoms are responsible for ~40% of marine primary production and are key players in global carbon cycling. There is mounting evidence that diatom growth is influenced by cobalamin (vitamin B(12)) availability. This cobalt-containing micronutrient is only produced by some bacteria and archaea but is required by many diatoms and other eukaryotic phytoplankton. Despite its potential importance, little is known about mechanisms of cobalamin acquisition in diatoms or the impact of cobalamin scarcity on diatom molecular physiology. Proteomic profiling and RNA-sequencing transcriptomic analysis of the cultured diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana revealed three distinct strategies used by diatoms to cope with low cobalamin: increased cobalamin acquisition machinery, decreased cobalamin demand, and management of reduced methionine synthase activity through changes in folate and S-adenosyl methionine metabolism. One previously uncharacterized protein, cobalamin acquisition protein 1 (CBA1), was up to 160-fold more abundant under low cobalamin availability in both diatoms. Autologous overexpression of CBA1 revealed association with the outside of the cell and likely endoplasmic reticulum localization. Cobalamin uptake rates were elevated in strains overexpressing CBA1, directly linking this protein to cobalamin acquisition. CBA1 is unlike characterized cobalamin acquisition proteins and is the only currently identified algal protein known to be implicated in cobalamin uptake. The abundance and widespread distribution of transcripts encoding CBA1 in environmental samples suggests that cobalamin is an important nutritional factor for phytoplankton. Future study of CBA1 and other molecular signatures of cobalamin scarcity identified here will yield insight into the evolution of cobalamin utilization and facilitate monitoring of cobalamin starvation in oceanic diatom communities.

  7. Acquisition, conservation, and loss of dual-targeted proteins in land plants.

    PubMed

    Xu, Lin; Carrie, Chris; Law, Simon R; Murcha, Monika W; Whelan, James

    2013-02-01

    The dual-targeting ability of a variety of proteins from Physcomitrella patens, rice (Oryza sativa), and Arabidopsis (Arabidopsis thaliana) was tested to determine when dual targeting arose and to what extent it was conserved in land plants. Overall, the targeting ability of over 80 different proteins from rice and P. patens, representing 42 dual-targeted proteins in Arabidopsis, was tested. We found that dual targeting arose early in land plant evolution, as it was evident in many cases with P. patens proteins that were conserved in rice and Arabidopsis. Furthermore, we found that the acquisition of dual-targeting ability is still occurring, evident in P. patens as well as rice and Arabidopsis. The loss of dual-targeting ability appears to be rare, but does occur. Ascorbate peroxidase represents such an example. After gene duplication in rice, individual genes encode proteins that are targeted to a single organelle. Although we found that dual targeting was generally conserved, the ability to detect dual-targeted proteins differed depending on the cell types used. Furthermore, it appears that small changes in the targeting signal can result in a loss (or gain) of dual-targeting ability. Overall, examination of the targeting signals within this study did not reveal any clear patterns that would predict dual-targeting ability. The acquisition of dual-targeting ability also appears to be coordinated between proteins. Mitochondrial intermembrane space import and assembly protein40, a protein involved in oxidative folding in mitochondria and peroxisomes, provides an example where acquisition of dual targeting is accompanied by the dual targeting of substrate proteins.

  8. Direct CRISPR spacer acquisition from RNA by a natural reverse-transcriptase-Cas1 fusion protein

    PubMed Central

    Sidote, David J.; Markham, Laura M.; Sanchez-Amat, Antonio; Bhaya, Devaki; Lambowitz, Alan M.; Fire, Andrew Z.

    2016-01-01

    CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat) systems mediate adaptive immunity in diverse prokaryotes. CRISPR-associated Cas1 and Cas2 proteins have been shown to enable adaptation to new threats in Type I and II CRISPR systems by the acquisition of short segments of DNA (“spacers”) from invasive elements. In several Type III CRISPR systems, Cas1 is naturally fused to a reverse transcriptase (RT). In the marine bacterium Marinomonas mediterranea (MMB-1), we show that an RT-Cas1 fusion enables the acquisition of RNA spacers in vivo in an RT-dependent manner. In vitro, the MMB-1 RT-Cas1 and Cas2 proteins catalyze ligation of RNA segments into the CRISPR array, followed by reverse transcription. These observations outline a host-mediated mechanism for reverse information flow from RNA to DNA. PMID:26917774

  9. Evolution of Helicobacter: Acquisition by Gastric Species of Two Histidine-Rich Proteins Essential for Colonization

    PubMed Central

    Vorontsov, Egor; Gallaud, Julien; Malosse, Christian; Michel, Valérie; Cavazza, Christine; Robbe-Saule, Marie; Richaud, Pierre; Chamot-Rooke, Julia; Brochier-Armanet, Céline; De Reuse, Hilde

    2015-01-01

    Metal acquisition and intracellular trafficking are crucial for all cells and metal ions have been recognized as virulence determinants in bacterial pathogens. Virulence of the human gastric pathogen Helicobacter pylori is dependent on nickel, cofactor of two enzymes essential for in vivo colonization, urease and [NiFe] hydrogenase. We found that two small paralogous nickel-binding proteins with high content in Histidine (Hpn and Hpn-2) play a central role in maintaining non-toxic intracellular nickel content and in controlling its intracellular trafficking. Measurements of metal resistance, intracellular nickel contents, urease activities and interactomic analysis were performed. We observed that Hpn acts as a nickel-sequestration protein, while Hpn-2 is not. In vivo, Hpn and Hpn-2 form homo-multimers, interact with each other, Hpn interacts with the UreA urease subunit while Hpn and Hpn-2 interact with the HypAB hydrogenase maturation proteins. In addition, Hpn-2 is directly or indirectly restricting urease activity while Hpn is required for full urease activation. Based on these data, we present a model where Hpn and Hpn-2 participate in a common pathway of controlled nickel transfer to urease. Using bioinformatics and top-down proteomics to identify the predicted proteins, we established that Hpn-2 is only expressed by H. pylori and its closely related species Helicobacter acinonychis. Hpn was detected in every gastric Helicobacter species tested and is absent from the enterohepatic Helicobacter species. Our phylogenomic analysis revealed that Hpn acquisition was concomitant with the specialization of Helicobacter to colonization of the gastric environment and the duplication at the origin of hpn-2 occurred in the common ancestor of H. pylori and H. acinonychis. Finally, Hpn and Hpn-2 were found to be required for colonization of the mouse model by H. pylori. Our data show that during evolution of the Helicobacter genus, acquisition of Hpn and Hpn-2 by gastric

  10. Ablation of RNAi and retrotransposons accompany acquisition and evolution of transposases to heterochromatin protein CENPB.

    PubMed

    Upadhyay, Udita; Srivastava, Suchita; Khatri, Indu; Nanda, Jagpreet Singh; Subramanian, Srikrishna; Arora, Amit; Singh, Jagmohan

    2017-02-22

    Inactivation of retrotransposons is accompanied by the emergence of CENPB (centromere binding protein-B) in Schizosaccharomyces as well as in metazoans. The RNAi-induced Transcriptional Silencing (RITS) Complex, comprising Chp1 (chromodomain protein-1), Tas3 (protein with unknown function) and Ago1 (Argonaute), plays an important role in RNAi-mediated heterochromatinization. We find that while the Ago1 subunit of the RITS complex is highly conserved, Tas3 is lost and Chp1 is truncated in S. cryophilus and S. octosporus We show that truncated Chp1 has lost the property of heterochromatin localization and silencing when transformed in S. pombe Furthermore, multiple copies of CENPB, related to Tc1/mariner and Tc5 transposons, occur in all Schizosaccharomyces species as well as in humans, but with loss of transposase function (except S. japonicus). We propose that acquisition of Tc1/mariner and Tc5 elements by horizontal transfer in S. pombe (and humans), is accompanied by alteration of their function from a transposase/ endonuclease to a heterochromatin protein, designed to suppress transposon expression and recombination. The resulting redundancy of RITS may have eased the selection pressure resulting in progressive loss or truncation of tas3 and chp1 genes in S. octosporus and S. cryophilus and triggered similar evolutionary dynamics in the metazoan orthologs.

  11. Autopilot: an online data acquisition control system for the enhanced high-throughput characterization of intact proteins.

    PubMed

    Durbin, Kenneth R; Fellers, Ryan T; Ntai, Ioanna; Kelleher, Neil L; Compton, Philip D

    2014-02-04

    The ability to study organisms by direct analysis of their proteomes without digestion via mass spectrometry has benefited greatly from recent advances in separation techniques, instrumentation, and bioinformatics. However, improvements to data acquisition logic have lagged in comparison. Past workflows for Top Down Proteomics (TDPs) have focused on high throughput at the expense of maximal protein coverage and characterization. This mode of data acquisition has led to enormous overlap in the identification of highly abundant proteins in subsequent LC-MS injections. Furthermore, a wealth of data is left underutilized by analyzing each newly targeted species as unique, rather than as part of a collection of fragmentation events on a distinct proteoform. Here, we present a major advance in software for acquisition of TDP data that incorporates a fully automated workflow able to detect intact masses, guide fragmentation to achieve maximal identification and characterization of intact protein species, and perform database search online to yield real-time protein identifications. On Pseudomonas aeruginosa, the software combines fragmentation events of the same precursor with previously obtained fragments to achieve improved characterization of the target form by an average of 42 orders of magnitude in confidence. When HCD fragmentation optimization was applied to intact proteins ions, there was an 18.5 order of magnitude gain in confidence. These improved metrics set the stage for increased proteome coverage and characterization of higher order organisms in the future for sharply improved control over MS instruments in a project- and lab-wide context.

  12. Autopilot: An Online Data Acquisition Control System for the Enhanced High-Throughput Characterization of Intact Proteins

    PubMed Central

    2015-01-01

    The ability to study organisms by direct analysis of their proteomes without digestion via mass spectrometry has benefited greatly from recent advances in separation techniques, instrumentation, and bioinformatics. However, improvements to data acquisition logic have lagged in comparison. Past workflows for Top Down Proteomics (TDPs) have focused on high throughput at the expense of maximal protein coverage and characterization. This mode of data acquisition has led to enormous overlap in the identification of highly abundant proteins in subsequent LC-MS injections. Furthermore, a wealth of data is left underutilized by analyzing each newly targeted species as unique, rather than as part of a collection of fragmentation events on a distinct proteoform. Here, we present a major advance in software for acquisition of TDP data that incorporates a fully automated workflow able to detect intact masses, guide fragmentation to achieve maximal identification and characterization of intact protein species, and perform database search online to yield real-time protein identifications. On Pseudomonas aeruginosa, the software combines fragmentation events of the same precursor with previously obtained fragments to achieve improved characterization of the target form by an average of 42 orders of magnitude in confidence. When HCD fragmentation optimization was applied to intact proteins ions, there was an 18.5 order of magnitude gain in confidence. These improved metrics set the stage for increased proteome coverage and characterization of higher order organisms in the future for sharply improved control over MS instruments in a project- and lab-wide context. PMID:24400813

  13. Protein kinase D1 is essential for bone acquisition during pubertal growth.

    PubMed

    Ford, Jeffery J; Yeh, Lee-Chuan C; Schmidgal, Eric C; Thompson, Jason F; Adamo, Martin L; Lee, John C

    2013-11-01

    Bone formation and maintenance represents the summation of the balance of local and endocrine hormonal stimuli within a complex organ. Protein kinase D (PKD) is a member of the Ca(2+)/calmodulin-dependent kinase superfamily of serine/threonine kinases and has been described as the crossroads for the bone morphogenetic protein (BMP)-IGF-I signaling axis, which plays a major role in bone formation. The current study exploits the PKD1-deficient mouse model to examine the role of PKD in vivo in the skeleton. Dual-energy x-ray absorptiometry scan analysis of male and female pubescent mice demonstrated significantly decreased bone mineral density in the whole body and femoral bone compartments of PKD1 (+/-) mice, compared with their wild-type littermates. The body weight, nasal-anal length, and percentage body fat of the mice were not significantly different from their wild-type littermates. Cultured bone marrow stromal cells from PKD1 (+/-) mice demonstrated lower alkaline phosphatase activity in early differentiating osteoblasts and decreased mineralized nodule formation in mature osteoblasts. Quantitative RT-PCR analysis of osteoblast differentiation markers and osteoclast markers exhibited lower levels of expression in PKD1 (+/-) male mice than wild type. In female mice, however, only markers of osteoblast differentiation were reduced. PKD1 (+/-) mice also demonstrated a profound reduction in mRNA expression levels of BMP type II receptor and IGF-I receptor and in BMP-7 responsiveness in vitro. Together these data suggest that in mice, PKD1 action contributes to the regulation of osteoblastogenesis by altering gene expression with gender-specific effects on osteoclastogenesis, subsequently affecting skeletal matrix acquisition during puberty.

  14. Acquisition of new protein domains by coronaviruses: analysis of overlapping genes coding for proteins N and 9b in SARS coronavirus.

    PubMed

    Shukla, Aditi; Hilgenfeld, Rolf

    2015-02-01

    Acquisition of new proteins by viruses usually occurs through horizontal gene transfer or through gene duplication, but another, less common mechanism is the usage of completely or partially overlapping reading frames. A case of acquisition of a completely new protein through introduction of a start codon in an alternative reading frame is the protein encoded by open reading frame (orf) 9b of SARS coronavirus. This gene completely overlaps with the nucleocapsid (N) gene (orf9a). Our findings indicate that the orf9b gene features a discordant codon-usage pattern. We analyzed the evolution of orf9b in concert with orf9a using sequence data of betacoronavirus-lineage b and found that orf9b, which encodes the overprinting protein, evolved largely independent of the overprinted orf9a. We also examined the protein products of these genomic sequences for their structural flexibility and found that it is not necessary for a newly acquired, overlapping protein product to be intrinsically disordered, in contrast to earlier suggestions. Our findings contribute to characterizing sequence properties of newly acquired genes making use of overlapping reading frames.

  15. Quantification of Lysine Acetylation and Succinylation Stoichiometry in Proteins Using Mass Spectrometric Data-Independent Acquisitions (SWATH)

    NASA Astrophysics Data System (ADS)

    Meyer, Jesse G.; D'Souza, Alexandria K.; Sorensen, Dylan J.; Rardin, Matthew J.; Wolfe, Alan J.; Gibson, Bradford W.; Schilling, Birgit

    2016-11-01

    Post-translational modification of lysine residues by NƐ-acylation is an important regulator of protein function. Many large-scale protein acylation studies have assessed relative changes of lysine acylation sites after antibody enrichment using mass spectrometry-based proteomics. Although relative acylation fold-changes are important, this does not reveal site occupancy, or stoichiometry, of individual modification sites, which is critical to understand functional consequences. Recently, methods for determining lysine acetylation stoichiometry have been proposed based on ratiometric analysis of endogenous levels to those introduced after quantitative per-acetylation of proteins using stable isotope-labeled acetic anhydride. However, in our hands, we find that these methods can overestimate acetylation stoichiometries because of signal interferences when endogenous levels of acylation are very low, which is especially problematic when using MS1 scans for quantification. In this study, we sought to improve the accuracy of determining acylation stoichiometry using data-independent acquisition (DIA). Specifically, we use SWATH acquisition to comprehensively collect both precursor and fragment ion intensity data. The use of fragment ions for stoichiometry quantification not only reduces interferences but also allows for determination of site-level stoichiometry from peptides with multiple lysine residues. We also demonstrate the novel extension of this method to measurements of succinylation stoichiometry using deuterium-labeled succinic anhydride. Proof of principle SWATH acquisition studies were first performed using bovine serum albumin for both acetylation and succinylation occupancy measurements, followed by the analysis of more complex samples of E. coli cell lysates. Although overall site occupancy was low (<1%), some proteins contained lysines with relatively high acetylation occupancy.

  16. Quantification of Lysine Acetylation and Succinylation Stoichiometry in Proteins Using Mass Spectrometric Data-Independent Acquisitions (SWATH).

    PubMed

    Meyer, Jesse G; D'Souza, Alexandria K; Sorensen, Dylan J; Rardin, Matthew J; Wolfe, Alan J; Gibson, Bradford W; Schilling, Birgit

    2016-11-01

    Post-translational modification of lysine residues by NƐ-acylation is an important regulator of protein function. Many large-scale protein acylation studies have assessed relative changes of lysine acylation sites after antibody enrichment using mass spectrometry-based proteomics. Although relative acylation fold-changes are important, this does not reveal site occupancy, or stoichiometry, of individual modification sites, which is critical to understand functional consequences. Recently, methods for determining lysine acetylation stoichiometry have been proposed based on ratiometric analysis of endogenous levels to those introduced after quantitative per-acetylation of proteins using stable isotope-labeled acetic anhydride. However, in our hands, we find that these methods can overestimate acetylation stoichiometries because of signal interferences when endogenous levels of acylation are very low, which is especially problematic when using MS1 scans for quantification. In this study, we sought to improve the accuracy of determining acylation stoichiometry using data-independent acquisition (DIA). Specifically, we use SWATH acquisition to comprehensively collect both precursor and fragment ion intensity data. The use of fragment ions for stoichiometry quantification not only reduces interferences but also allows for determination of site-level stoichiometry from peptides with multiple lysine residues. We also demonstrate the novel extension of this method to measurements of succinylation stoichiometry using deuterium-labeled succinic anhydride. Proof of principle SWATH acquisition studies were first performed using bovine serum albumin for both acetylation and succinylation occupancy measurements, followed by the analysis of more complex samples of E. coli cell lysates. Although overall site occupancy was low (<1%), some proteins contained lysines with relatively high acetylation occupancy. Graphical Abstract ᅟ.

  17. Evolution of photorespiration from cyanobacteria to land plants, considering protein phylogenies and acquisition of carbon concentrating mechanisms.

    PubMed

    Hagemann, Martin; Kern, Ramona; Maurino, Veronica G; Hanson, David T; Weber, Andreas P M; Sage, Rowan F; Bauwe, Hermann

    2016-05-01

    Photorespiration and oxygenic photosynthesis are intimately linked processes. It has been shown that under the present day atmospheric conditions cyanobacteria and all eukaryotic phototrophs need functional photorespiration to grow autotrophically. The question arises as to when this essential partnership evolved, i.e. can we assume a coevolution of both processes from the beginning or did photorespiration evolve later to compensate for the generation of 2-phosphoglycolate (2PG) due to Rubisco's oxygenase reaction? This question is mainly discussed here using phylogenetic analysis of proteins involved in the 2PG metabolism and the acquisition of different carbon concentrating mechanisms (CCMs). The phylogenies revealed that the enzymes involved in the photorespiration of vascular plants have diverse origins, with some proteins acquired from cyanobacteria as ancestors of the chloroplasts and others from heterotrophic bacteria as ancestors of mitochondria in the plant cell. Only phosphoglycolate phosphatase was found to originate from Archaea. Notably glaucophyte algae, the earliest branching lineage of Archaeplastida, contain more photorespiratory enzymes of cyanobacterial origin than other algal lineages or land plants indicating a larger initial contribution of cyanobacterial-derived proteins to eukaryotic photorespiration. The acquisition of CCMs is discussed as a proxy for assessing the timing of periods when photorespiratory activity may have been enhanced. The existence of CCMs also had marked influence on the structure and function of photorespiration. Here, we discuss evidence for an early and continuous coevolution of photorespiration, CCMs and photosynthesis starting from cyanobacteria via algae, to land plants.

  18. IlsA, a unique surface protein of Bacillus cereus required for iron acquisition from heme, hemoglobin and ferritin.

    PubMed

    Daou, Nadine; Buisson, Christophe; Gohar, Michel; Vidic, Jasmina; Bierne, Hélène; Kallassy, Mireille; Lereclus, Didier; Nielsen-LeRoux, Christina

    2009-11-01

    The human opportunistic pathogen Bacillus cereus belongs to the B. cereus group that includes bacteria with a broad host spectrum. The ability of these bacteria to colonize diverse hosts is reliant on the presence of adaptation factors. Previously, an IVET strategy led to the identification of a novel B. cereus protein (IlsA, Iron-regulated leucine rich surface protein), which is specifically expressed in the insect host or under iron restrictive conditions in vitro. Here, we show that IlsA is localized on the surface of B. cereus and hence has the potential to interact with host proteins. We report that B. cereus uses hemoglobin, heme and ferritin, but not transferrin and lactoferrin. In addition, affinity tests revealed that IlsA interacts with both hemoglobin and ferritin. Furthermore, IlsA directly binds heme probably through the NEAT domain. Inactivation of ilsA drastically decreases the ability of B. cereus to grow in the presence of hemoglobin, heme and ferritin, indicating that IlsA is essential for iron acquisition from these iron sources. In addition, the ilsA mutant displays a reduction in growth and virulence in an insect model. Hence, our results indicate that IlsA is a key factor within a new iron acquisition system, playing an important role in the general virulence strategy adapted by B. cereus to colonize susceptible hosts.

  19. Protein synthesis is not required for acquisition, consolidation, and extinction of high foot-shock active avoidance training.

    PubMed

    González-Salinas, Sofía; Medina, Andrea C; Marín-Vignando, Vera; Ruiz-López, Clyo X; Quirarte, Gina L; Prado-Alcalá, Roberto A

    2015-01-01

    Long-term memory of active avoidance in mice is not disturbed by administration of protein synthesis inhibitors (PSIs) when relatively high levels of training are used, whereas a detrimental effect is produced with lower levels of training. PSIs also disrupt extinction of avoidance behaviors in rodents, but it is not clear whether PSIs also affect this form of learning when the behavior to be extinguished was produced by a high level of training. Experiment 1 demonstrated that rats treated with the PSI cycloheximide (CXM) 30 min before training developed normal acquisition after training with either high or low foot-shock stimulation, but that memory consolidation was hindered only after low foot-shock training. Experiment 2 demonstrated that CXM disrupted extinction when administered before the first of a series of extinction sessions when low foot-shock intensity was used during training; in contrast, after training with a higher foot-shock, the PSI treatment only interfered transiently with extinction. These results indicate that acquisition, consolidation, and extinction of active avoidance learning produced by high aversive stimulation are not dependent on protein synthesis and that these processes are governed by mechanisms different from those underlying moderate forms of learning.

  20. Simultaneous acquisition of 2D and 3D solid-state NMR experiments for sequential assignment of oriented membrane protein samples.

    PubMed

    Gopinath, T; Mote, Kaustubh R; Veglia, Gianluigi

    2015-05-01

    We present a new method called DAISY (Dual Acquisition orIented ssNMR spectroScopY) for the simultaneous acquisition of 2D and 3D oriented solid-state NMR experiments for membrane proteins reconstituted in mechanically or magnetically aligned lipid bilayers. DAISY utilizes dual acquisition of sine and cosine dipolar or chemical shift coherences and long living (15)N longitudinal polarization to obtain two multi-dimensional spectra, simultaneously. In these new experiments, the first acquisition gives the polarization inversion spin exchange at the magic angle (PISEMA) or heteronuclear correlation (HETCOR) spectra, the second acquisition gives PISEMA-mixing or HETCOR-mixing spectra, where the mixing element enables inter-residue correlations through (15)N-(15)N homonuclear polarization transfer. The analysis of the two 2D spectra (first and second acquisitions) enables one to distinguish (15)N-(15)N inter-residue correlations for sequential assignment of membrane proteins. DAISY can be implemented in 3D experiments that include the polarization inversion spin exchange at magic angle via I spin coherence (PISEMAI) sequence, as we show for the simultaneous acquisition of 3D PISEMAI-HETCOR and 3D PISEMAI-HETCOR-mixing experiments.

  1. Ready, Set, Fuse! The Coronavirus Spike Protein and Acquisition of Fusion Competence

    PubMed Central

    Heald-Sargent, Taylor; Gallagher, Tom

    2012-01-01

    Coronavirus-cell entry programs involve virus-cell membrane fusions mediated by viral spike (S) proteins. Coronavirus S proteins acquire membrane fusion competence by receptor interactions, proteolysis, and acidification in endosomes. This review describes our current understanding of the S proteins, their interactions with and their responses to these entry triggers. We focus on receptors and proteases in prompting entry and highlight the type II transmembrane serine proteases (TTSPs) known to activate several virus fusion proteins. These and other proteases are essential cofactors permitting coronavirus infection, conceivably being in proximity to cell-surface receptors and thus poised to split entering spike proteins into the fragments that refold to mediate membrane fusion. The review concludes by noting how understanding of coronavirus entry informs antiviral therapies. PMID:22590686

  2. Absolute quantification of proteins by LCMSE: a virtue of parallel MS acquisition.

    PubMed

    Silva, Jeffrey C; Gorenstein, Marc V; Li, Guo-Zhong; Vissers, Johannes P C; Geromanos, Scott J

    2006-01-01

    Relative quantification methods have dominated the quantitative proteomics field. There is a need, however, to conduct absolute quantification studies to accurately model and understand the complex molecular biology that results in proteome variability among biological samples. A new method of absolute quantification of proteins is described. This method is based on the discovery of an unexpected relationship between MS signal response and protein concentration: the average MS signal response for the three most intense tryptic peptides per mole of protein is constant within a coefficient of variation of less than +/-10%. Given an internal standard, this relationship is used to calculate a universal signal response factor. The universal signal response factor (counts/mol) was shown to be the same for all proteins tested in this study. A controlled set of six exogenous proteins of varying concentrations was studied in the absence and presence of human serum. The absolute quantity of the standard proteins was determined with a relative error of less than +/-15%. The average MS signal responses of the three most intense peptides from each protein were plotted against their calculated protein concentrations, and this plot resulted in a linear relationship with an R(2) value of 0.9939. The analyses were applied to determine the absolute concentration of 11 common serum proteins, and these concentrations were then compared with known values available in the literature. Additionally within an unfractionated Escherichia coli lysate, a subset of identified proteins known to exist as functional complexes was studied. The calculated absolute quantities were used to accurately determine their stoichiometry.

  3. Acquisition of an oncogenic fusion protein serves as an initial driving mutation by inducing aneuploidy and overriding proliferative defects

    PubMed Central

    Maggi, Elaine C.; Vijayaraghavan, Jyothi; Zabaleta, Jovanny; Taylor, Christopher M.; Tsien, Fern; Crabtree, Judy S.; Hollenbach, Andrew D.

    2016-01-01

    While many solid tumors are defined by the presence of a particular oncogene, the role that this oncogene plays in driving transformation through the acquisition of aneuploidy and overcoming growth arrest are often not known. Further, although aneuploidy is present in many solid tumors, it is not clear whether it is the cause or effect of malignant transformation. The childhood sarcoma, Alveolar Rhabdomyosarcoma (ARMS), is primarily defined by the t(2;13)(q35;q14) translocation, creating the PAX3-FOXO1 fusion protein. It is unclear what role PAX3-FOXO1 plays in the initial stages of tumor development through the acquisition and persistence of aneuploidy. In this study we demonstrate that PAX3-FOXO1 serves as a driver mutation to initiate a cascade of mRNA and miRNA changes that ultimately reprogram proliferating myoblasts to induce the formation of ARMS. We present evidence that cells containing PAX3-FOXO1 have changes in the expression of mRNA and miRNA essential for maintaining proper chromosome number and structure thereby promoting aneuploidy. Further, we demonstrate that the presence of PAX3-FOXO1 alters the expression of growth factor related mRNA and miRNA, thereby overriding aneuploid-dependent growth arrest. Finally, we present evidence that phosphorylation of PAX3-FOXO1 contributes to these changes. This is one of the first studies describing how an oncogene and post-translational modifications drive the development of a tumor through the acquisition and persistence of aneuploidy. This mechanism has implications for other solid tumors where large-scale genomics studies may elucidate how global alterations contribute to tumor phenotypes allowing the development of much needed multi-faceted tumor-specific therapeutic regimens. PMID:27588498

  4. Sequential depletion and acquisition of proteins during Golgi stack disassembly and reformation.

    PubMed

    Schoberer, Jennifer; Runions, John; Steinkellner, Herta; Strasser, Richard; Hawes, Chris; Osterrieder, Anne

    2010-11-01

    Herein, we report the stepwise transport of multiple plant Golgi membrane markers during disassembly of the Golgi apparatus in tobacco leaf epidermal cells in response to the induced expression of the GTP-locked Sar1p or Brefeldin A (BFA), and reassembly on BFA washout. The distribution of fluorescent Golgi-resident N-glycan processing enzymes and matrix proteins (golgins) with specific cis-trans-Golgi sub-locations was followed by confocal microscopy during disassembly and reassembly. The first event during Golgi disassembly was the loss of trans-Golgi enzymes and golgins from Golgi membranes, followed by a sequential redistribution of medial and cis-Golgi enzymes into the endoplasmic reticulum (ER), whilst golgins were relocated to the ER or cytoplasm. This event was confirmed by fractionation and immuno-blotting. The sequential redistribution of Golgi components in a trans-cis sequence may highlight a novel retrograde trafficking pathway between the trans-Golgi and the ER in plants. Release of Golgi markers from the ER upon BFA washout occurred in the opposite sequence, with cis-matrix proteins labelling Golgi-like structures before cis/medial enzymes. Trans-enzyme location was preceded by trans-matrix proteins being recruited back to Golgi membranes. Our results show that Golgi disassembly and reassembly occur in a highly ordered fashion in plants.

  5. A peptidoglycan recognition protein acts in whitefly (Bemisia tabaci) immunity and involves in Begomovirus acquisition

    PubMed Central

    Wang, Zhi-Zhi; Shi, Min; Huang, Yi-Cun; Wang, Xiao-Wei; Stanley, David; Chen, Xue-Xin

    2016-01-01

    Peptidoglycan recognition proteins (PGRPs) are multifunctional pattern recognition proteins. Here, we report that a PGRP gene, BtPGRP, encodes a PGRP from the whitefly Bemisia tabaci (MEAM1) that binds and kills bacteria in vitro. We analyzed BtPGRP transcriptional profiling, and the distribution of the cognate protein within the midgut. Fungal infection and wasp parasitization induced expression of BtPGRP. Silencing BtPGRP with artificial media amended with dsRNA led to reduced expression of a gene encoding an antimicrobial peptide, B. tabaci c-type lysozyme. Begomovirus infection also led to increased expression of BtPGRP. We propose that BtPGRP has a potential Tomato yellow leaf curl virus (TYLCV) binding site because we detected in vitro interaction between BtPGRP and TYLCV by immunocapture PCR, and recorded the co-localization of TYLCV and BtPGRP in midguts. This work addresses a visible gap in understanding whitefly immunity and provides insight into how the whitefly immunity acts in complex mechanisms of Begomovirus transmission among plants. PMID:27892529

  6. Multiple acquisition of magic angle spinning solid-state NMR experiments using one receiver: Application to microcrystalline and membrane protein preparations

    NASA Astrophysics Data System (ADS)

    Gopinath, T.; Veglia, Gianluigi

    2015-04-01

    Solid-state NMR spectroscopy of proteins is a notoriously low-throughput technique. Relatively low-sensitivity and poor resolution of protein samples require long acquisition times for multidimensional NMR experiments. To speed up data acquisition, we developed a family of experiments called Polarization Optimized Experiments (POE), in which we utilized the orphan spin operators that are discarded in classical multidimensional NMR experiments, recovering them to allow simultaneous acquisition of multiple 2D and 3D experiments, all while using conventional probes with spectrometers equipped with one receiver. POE allow the concatenation of multiple 2D or 3D pulse sequences into a single experiment, thus potentially combining all of the aforementioned advances, boosting the capability of ssNMR spectrometers at least two-fold without the addition of any hardware. In this perspective, we describe the first generation of POE, such as dual acquisition MAS (or DUMAS) methods, and then illustrate the evolution of these experiments into MEIOSIS, a method that enables the simultaneous acquisition of multiple 2D and 3D spectra. Using these new pulse schemes for the solid-state NMR investigation of biopolymers makes it possible to obtain sequential resonance assignments, as well as distance restraints, in about half the experimental time. While designed for acquisition of heteronuclei, these new experiments can be easily implemented for proton detection and coupled with other recent advancements, such as dynamic nuclear polarization (DNP), to improve signal to noise. Finally, we illustrate the application of these methods to microcrystalline protein preparations as well as single and multi-span membrane proteins reconstituted in lipid membranes.

  7. Multiple acquisition of magic angle spinning solid-state NMR experiments using one receiver: application to microcrystalline and membrane protein preparations.

    PubMed

    Gopinath, T; Veglia, Gianluigi

    2015-04-01

    Solid-state NMR spectroscopy of proteins is a notoriously low-throughput technique. Relatively low-sensitivity and poor resolution of protein samples require long acquisition times for multidimensional NMR experiments. To speed up data acquisition, we developed a family of experiments called Polarization Optimized Experiments (POE), in which we utilized the orphan spin operators that are discarded in classical multidimensional NMR experiments, recovering them to allow simultaneous acquisition of multiple 2D and 3D experiments, all while using conventional probes with spectrometers equipped with one receiver. POE allow the concatenation of multiple 2D or 3D pulse sequences into a single experiment, thus potentially combining all of the aforementioned advances, boosting the capability of ssNMR spectrometers at least two-fold without the addition of any hardware. In this perspective, we describe the first generation of POE, such as dual acquisition MAS (or DUMAS) methods, and then illustrate the evolution of these experiments into MEIOSIS, a method that enables the simultaneous acquisition of multiple 2D and 3D spectra. Using these new pulse schemes for the solid-state NMR investigation of biopolymers makes it possible to obtain sequential resonance assignments, as well as distance restraints, in about half the experimental time. While designed for acquisition of heteronuclei, these new experiments can be easily implemented for proton detection and coupled with other recent advancements, such as dynamic nuclear polarization (DNP), to improve signal to noise. Finally, we illustrate the application of these methods to microcrystalline protein preparations as well as single and multi-span membrane proteins reconstituted in lipid membranes.

  8. Efficient acquisition of high-resolution 4-D diagonal-suppressed methyl-methyl NOESY for large proteins

    NASA Astrophysics Data System (ADS)

    Wen, Jie; Zhou, Pei; Wu, Jihui

    2012-05-01

    The methyl-methyl NOESY experiment plays an important role in determining the global folds of large proteins. Despite the high sensitivity of this experiment, the analysis of methyl-methyl NOEs is frequently hindered by the limited chemical shift dispersion of methyl groups, particularly methyl protons. This makes it difficult to unambiguously assign all of the methyl-methyl NOE crosspeaks using 3-D spectroscopy. The recent development of sparse sampling methods enables highly efficient acquisition of high-resolution 4-D spectra, which provides an excellent solution to resolving the degeneracy of methyl signals. However, many reconstruction algorithms for processing sparsely-sampled NMR data do not provide adequate suppression of aliasing artifacts in the presence of strong NOE diagonal signals. In order to overcome this limitation, we present a 4-D diagonal-suppressed methyl-methyl NOESY experiment specifically optimized for ultrasparse sampling and evaluate it using a deuterated, ILV methyl-protonated sample of the 42 kDa Escherichia coli maltose binding protein (MBP). Suppression of diagonal signals removes the dynamic range barrier of the methyl-methyl NOESY experiment such that residual aliasing artifacts in the CLEAN-reconstructed high-resolution 4-D spectrum can be further reduced. At an ultrasparse sampling rate of less than 1%, we were able to identify and unambiguously assign the vast majority of expected NOE crosspeaks between methyl groups separated by less than 5 Å and to detect very weak NOE crosspeaks from methyl groups that are over 7 Å apart.

  9. Application of wide selected-ion monitoring data-independent acquisition to identify tomato fruit proteins regulated by the CUTIN DEFICIENT2 transcription factor

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We describe here the use of label-free wide selected-ion monitoring data-independent acquisition (WiSIM-DIA) to identify proteins that are involved in the formation of tomato (Solanum lycopersicum) fruit cuticles and that are regulated by the transcription factor CUTIN DEFICIENT2 (CD2). A spectral l...

  10. Cryptococcus neoformans requires the ESCRT protein Vps23 for iron acquisition from heme, for capsule formation, and for virulence.

    PubMed

    Hu, Guanggan; Caza, Mélissa; Cadieux, Brigitte; Chan, Vivienne; Liu, Victor; Kronstad, James

    2013-01-01

    Iron availability is a key regulator of virulence factor elaboration in Cryptococcus neoformans, the causative agent of fungal meningoencephalitis in HIV/AIDS patients. In addition, iron is an essential nutrient for pathogen proliferation in mammalian hosts but little is known about the mechanisms of iron sensing and uptake in fungal pathogens that attack humans. In this study, we mutagenized C. neoformans by Agrobacterium-mediated T-DNA insertion and screened for mutants with reduced growth on heme as the sole iron source. Among 34 mutants, we identified a subset with insertions in the gene for the ESCRT-I (endosomal sorting complex required for transport) protein Vps23 that resulted in a growth defect on heme, presumably due to a defect in uptake via endocytosis or misregulation of iron acquisition from heme. Remarkably, vps23 mutants were also defective in the elaboration of the cell-associated capsular polysaccharide that is a major virulence factor, while overexpression of Vps23 resulted in cells with a slightly enlarged capsule. These phenotypes were mirrored by a virulence defect in the vps23 mutant in a mouse model of cryptococcosis and by hypervirulence of the overexpression strain. Overall, these results reveal an important role for trafficking via ESCRT functions in both heme uptake and capsule formation, and they further reinforce the connection between iron and virulence factor deployment in C. neoformans.

  11. Shu1 Is a Cell-surface Protein Involved in Iron Acquisition from Heme in Schizosaccharomyces pombe*

    PubMed Central

    Mourer, Thierry; Jacques, Jean-François; Brault, Ariane; Bisaillon, Martin; Labbé, Simon

    2015-01-01

    Iron is an essential metal cofactor that is required for many biological processes. Eukaryotic cells have consequently developed different strategies for its acquisition. Until now, Schizosaccharomyces pombe was known to use reductive iron uptake and siderophore-bound iron transport to scavenge iron from the environment. Here, we report the identification of a gene designated shu1+ that encodes a protein that enables S. pombe to take up extracellular heme for cell growth. When iron levels are low, the transcription of shu1+ is induced, although its expression is repressed when iron levels rise. The iron-dependent down-regulation of shu1+ requires the GATA-type transcriptional repressor Fep1, which strongly associates with a proximal promoter region of shu1+ in vivo in response to iron repletion. HA4-tagged Shu1 localizes to the plasma membrane in cells expressing a functional shu1+-HA4 allele. When heme biosynthesis is selectively blocked in mutated S. pombe cells, their ability to acquire exogenous hemin or the fluorescent heme analog zinc mesoporphyrin IX is dependent on the expression of Shu1. Further analysis by absorbance spectroscopy and hemin-agarose pulldown assays showed that Shu1 interacts with hemin, with a KD of ∼2.2 μm. Taken together, results reported here revealed that S. pombe possesses an unexpected pathway for heme assimilation, which may also serve as a source of iron for cell growth. PMID:25733668

  12. Application of wide selected-ion monitoring data-independent acquisition to identify tomato fruit proteins regulated by the CUTIN DEFICIENT2 transcription factor.

    PubMed

    Martin, Laetitia B B; Sherwood, Robert W; Nicklay, Joshua J; Yang, Yong; Muratore-Schroeder, Tara L; Anderson, Elizabeth T; Thannhauser, Theodore W; Rose, Jocelyn K C; Zhang, Sheng

    2016-08-01

    We describe here the use of label-free wide selected-ion monitoring data-independent acquisition (WiSIM-DIA) to identify proteins that are involved in the formation of tomato (Solanum lycopersicum) fruit cuticles and that are regulated by the transcription factor CUTIN DEFICIENT2 (CD2). A spectral library consisting of 11 753 unique peptides, corresponding to 2338 tomato protein groups, was used and the DIA analysis was performed at the MS1 level utilizing narrow mass windows for extraction with Skyline 2.6 software. We identified a total of 1140 proteins, 67 of which had expression levels that differed significantly between the cd2 tomato mutant and the wild-type cultivar M82. Differentially expressed proteins including a key protein involved in cutin biosynthesis, were selected for validation by target SRM/MRM and by Western blot analysis. In addition to confirming a role for CD2 in regulating cuticle formation, the results also revealed that CD2 influences pathways associated with cell wall biology, anthocyanin biosynthesis, plant development, and responses to stress, which complements findings of earlier RNA-Seq experiments. Our results provide new insights into molecular processes and aspects of fruit biology associated with CD2 function, and demonstrate that the WiSIM-DIA is an effective quantitative approach for global protein identifications.

  13. Acquisition of complement inhibitor serine protease factor I and its cofactors C4b-binding protein and factor H by Prevotella intermedia.

    PubMed

    Malm, Sven; Jusko, Monika; Eick, Sigrun; Potempa, Jan; Riesbeck, Kristian; Blom, Anna M

    2012-01-01

    Infection with the Gram-negative pathogen Prevotella intermedia gives rise to periodontitis and a growing number of studies implies an association of P. intermedia with rheumatoid arthritis. The serine protease Factor I (FI) is the central inhibitor of complement degrading complement components C3b and C4b in the presence of cofactors such as C4b-binding protein (C4BP) and Factor H (FH). Yet, the significance of complement inhibitor acquisition in P. intermedia infection and FI binding by Gram-negative pathogens has not been addressed. Here we show that P. intermedia isolates bound purified FI as well as FI directly from heat-inactivated human serum. FI bound to bacteria retained its serine protease activity as shown in degradation experiments with (125)I-labeled C4b. Since FI requires cofactors for its activity we also investigated the binding of purified cofactors C4BP and FH and found acquisition of both proteins, which retained their activity in FI mediated degradation of C3b and C4b. We propose that FI binding by P. intermedia represents a new mechanism contributing to complement evasion by a Gram-negative bacterial pathogen associated with chronic diseases.

  14. The Secreted Proteins of Achlya hypogyna and Thraustotheca clavata Identify the Ancestral Oomycete Secretome and Reveal Gene Acquisitions by Horizontal Gene Transfer

    PubMed Central

    Misner, Ian; Blouin, Nic; Leonard, Guy; Richards, Thomas A.; Lane, Christopher E.

    2015-01-01

    Saprotrophic and parasitic microorganisms secrete proteins into the environment to breakdown macromolecules and obtain nutrients. The molecules secreted are collectively termed the “secretome” and the composition and function of this set of proteins varies depending on the ecology, life cycle, and environment of an organism. Beyond the function of nutrient acquisition, parasitic lineages must also secrete molecules to manipulate their host. Here, we use a combination of de novo genome and transcriptome sequencing and bioinformatic identification of signal peptides to identify the putative secreted proteome of two oomycetes, the facultative parasite Achlya hypogyna and free-living Thraustotheca clavata. By comparing the secretomes of these saprolegnialean oomycetes with that of eight other oomycetes, we were able to characterize the evolution of this protein set across the oomycete clade. These species span the last common ancestor of the two major oomycete families allowing us to identify the ancestral secretome. This putative ancestral secretome consists of at least 84 gene families. Only 11 of these gene families are conserved across all 10 secretomes analyzed and the two major branches in the oomycete radiation. Notably, we have identified expressed elicitin-like effector genes in the saprotrophic decomposer, T. clavata. Phylogenetic analyses show six novel horizontal gene transfers to the oomycete secretome from bacterial and fungal donor lineages, four of which are specific to the Saprolegnialeans. Comparisons between free-living and pathogenic taxa highlight the functional changes of oomycete secretomes associated with shifts in lifestyle. PMID:25527045

  15. Analysis of iron acquisition and storage-related genes in clinical and non-clinical strains of Yersinia enterocolitica biovar 1A.

    PubMed

    Kanaujia, Pawan Kumar; Bajaj, Priyanka; Virdi, Jugsharan Singh

    2015-10-01

    Possession of mechanisms for iron acquisition and its storage enhances the ability of the bacteria to survive in the iron-limiting environment of the host. In this study, 81 strains of Yersinia enterocolitica biovar 1A isolated from various clinical (n = 51) and non-clinical (n = 30) sources were investigated for the presence of the genes related to iron acquisition and storage. Important genes which were present in more than 85% of the strains included hasA, foxA, bfr, bfd, ftnA, and hmsT as well as the fhuCDB, fepBDGCfesfepA, feoAB, yfuABCD, hemPRSTUV, and hmsHFRS gene clusters. Majority of these genes is being reported for the first time in biovar 1A strains and showed significant homology with genes present in the known pathogenic biovars of Y. enterocolitica. However, no significant difference was observed in the distribution of iron acquisition and storage-related genes among clinical and non-clinical biovar 1A strains. Thus, it may be suggested that the presence of iron acquisition and storage-related genes per se might not be responsible for the supposedly better ability of clinical biovar 1A strains to cause infections in humans. However, in the backdrop of this data, the need to undertake functional studies are highly recommended.

  16. The structure of lactoferrin-binding protein B from Neisseria meningitidis suggests roles in iron acquisition and neutralization of host defences

    PubMed Central

    Brooks, Cory L.; Arutyunova, Elena; Lemieux, M. Joanne

    2014-01-01

    Pathogens have evolved a range of mechanisms to acquire iron from the host during infection. Several Gram-negative pathogens including members of the genera Neisseria and Moraxella have evolved two-component systems that can extract iron from the host glycoproteins lactoferrin and transferrin. The homologous iron-transport systems consist of a membrane-bound transporter and an accessory lipoprotein. While the mechanism behind iron acquisition from transferrin is well understood, relatively little is known regarding how iron is extracted from lactoferrin. Here, the crystal structure of the N-terminal domain (N-lobe) of the accessory lipoprotein lactoferrin-binding protein B (LbpB) from the pathogen Neisseria meningitidis is reported. The structure is highly homologous to the previously determined structures of the accessory lipoprotein transferrin-binding protein B (TbpB) and LbpB from the bovine pathogen Moraxella bovis. Docking the LbpB structure with lactoferrin reveals extensive binding interactions with the N1 subdomain of lactoferrin. The nature of the interaction precludes apolactoferrin from binding LbpB, ensuring the specificity of iron-loaded lactoferrin. The specificity of LbpB safeguards proper delivery of iron-bound lactoferrin to the transporter lactoferrin-binding protein A (LbpA). The structure also reveals a possible secondary role for LbpB in protecting the bacteria from host defences. Following proteolytic digestion of lactoferrin, a cationic peptide derived from the N-terminus is released. This peptide, called lactoferricin, exhibits potent antimicrobial effects. The docked model of LbpB with lactoferrin reveals that LbpB interacts extensively with the N-terminal lactoferricin region. This may provide a venue for preventing the production of the peptide by proteolysis, or directly sequestering the peptide, protecting the bacteria from the toxic effects of lactoferricin. PMID:25286931

  17. Mergers + acquisitions.

    PubMed

    Hoppszallern, Suzanna

    2002-05-01

    The hospital sector in 2001 led the health care field in mergers and acquisitions. Most deals involved a network augmenting its presence within a specific region or in a market adjacent to its primary service area. Analysts expect M&A activity to increase in 2002.

  18. Acquisition strategies

    SciTech Connect

    Zimmer, M.J.; Lynch, P.W. )

    1993-11-01

    Acquiring projects takes careful planning, research and consideration. Picking the right opportunities and avoiding the pitfalls will lead to a more valuable portfolio. This article describes the steps to take in evaluating an acquisition and what items need to be considered in an evaluation.

  19. Proteolytic processing of a protein involved in sperm-egg fusion correlates with acquisition of fertilization competence

    PubMed Central

    1990-01-01

    A protein located on the surface of guinea pig sperm (PH-30) has been implicated in the process of sperm-egg fusion (Primakoff, P., H. Hyatt, and J. Tredick-Kline. 1987. J. Cell Biol. 104:141-149). In this paper we have assessed basic biochemical properties of PH-30 and have analyzed the molecular forms of PH-30 present at different stages of sperm maturation. We show the following: (a) PH-30 is an integral membrane glycoprotein; (b) it is composed of two tightly associated and immunologically distinct subunits; (c) both subunits are made as larger precursors; (d) processing of the two subunits occurs at different developmental stages; (e) the final processing step occurs in the region of the epididymis where sperm become fertilization competent; (f) processing can be mimicked in vitro; (g) processing exposes at least two new epitopes on PH-30-one of the newly exposed epitopes is recognized by a fusion-inhibitory monoclonal antibody. These results are discussed in terms of the possible role of PH-30 in mediating fusion with the egg plasma membrane. PMID:2114412

  20. Tandem mass spectrometry acquisition approaches to enhance identification of protein-protein interactions using low-energy collision-induced dissociative chemical crosslinking reagents.

    PubMed

    Soderblom, Erik J; Bobay, Benjamin G; Cavanagh, John; Goshe, Michael B

    2007-01-01

    Chemical crosslinking combined with mass spectrometry is a useful tool for studying the topological organization of multiprotein interactions, but it is technically challenging to identify peptides involved in a crosslink using tandem mass spectrometry (MS/MS) due to the presence of product ions originating from both peptides within the same crosslink. We have previously developed a novel set of collision-induced dissociative chemical crosslinking reagents (CID-CXL reagents) that incorporate a labile bond within the linker which readily dissociates at a single site under low-energy collision-induced dissociation (CID) to enable independent isolation and sequencing of the crosslinked peptides by traditional MS/MS and database searching. Alternative low-energy CID events were developed within the in-source region by increasing the multipole DC offset voltage (ISCID) or within the ion trap by increasing the collisional excitation (ITCID). Both dissociation events, each having their unique advantages, occur without significant backbone fragmentation to the peptides, thus permitting subsequent CID to be applied to these distinct peptide ions for generation of suitable product ion spectra for database searching. Each approach was developed and applied to a chemical crosslinking study involving the N-terminal DNA-binding domain of AbrB (AbrBN), a transition-state regulator in Bacillus subtilis. A total of thirteen unique crosslinks were identified using the ITCID approach which represented a significant improvement over the eight unique crosslinks identified using the ISCID approach. The ability to segregate intrapeptide and interpeptide crosslinks using ITCID represents the first step towards high-throughput analysis of protein-protein crosslinks using our CID-CXL reagents.

  1. Boosting of ALVAC-SIV Vaccine-Primed Macaques with the CD4-SIVgp120 Fusion Protein Elicits Antibodies to V2 Associated with a Decreased Risk of SIVmac251 Acquisition

    PubMed Central

    Gordon, Shari N.; Liyanage, Namal P. M.; Doster, Melvin N.; Vaccari, Monica; Vargas-Inchaustegui, Diego A.; Pegu, Poonam; Schifanella, Luca; Shen, Xiaoying; Tomaras, Georgia D.; Rao, Mangala; Billings, Erik A.; Schwartz, Jennifer; Prado, Ilia; Bobb, Kathryn; Zhang, Wenlei; Montefiori, David C.; Foulds, Kathryn E.; Ferrari, Guido; Robert-Guroff, Marjorie; Roederer, Mario; Phan, Tran B.; Forthal, Donald N.; Stablein, Donald M.; Phogat, Sanjay; Venzon, David J.; Fouts, Timothy

    2016-01-01

    The recombinant ALVAC vaccine coupled with the monomeric gp120/alum protein have decreased the risk of HIV and SIV acquisition. Ab responses to the V1/V2 regions have correlated with a decreased risk of virus acquisition in both humans and macaques. We hypothesized that the breadth and functional profile of Abs induced by an ALVAC/envelope protein regimen could be improved by substituting the monomeric gp120 boost, with the full-length single-chain (FLSC) protein. FLSC is a CD4-gp120 fusion immunogen that exposes cryptic gp120 epitopes to the immune system. We compared the immunogenicity and relative efficiency of an ALVAC-SIV vaccine boosted either with bivalent FLSC proteins or with monomeric gp120 in alum. FLSC was superior to monomeric gp120 in directing Abs to the C3 α2 helix, the V5 loop, and the V3 region that contains the putative CCR5 binding site. In addition, FLSC boosting elicited significantly higher binding Abs to V2 and increased both the Ab-dependent cellular cytotoxicity activity and the breadth of neutralizing Abs. However, the FLSC vaccine regimen demonstrated only a trend in vaccine efficacy, whereas the monomeric gp120 regimen significantly decreased the risk of SIVmac251 acquisition. In both vaccine regimens, anti-V2 Abs correlated with a decreased risk of virus acquisition but differed with regard to systemic or mucosal origin. In the FLSC regimen, serum Abs to V2 correlated, whereas in the monomeric gp120 regimen, V2 Abs in rectal secretions, the site of viral challenge, were associated with efficacy. PMID:27591322

  2. The pathway by which the yeast protein kinase Snf1p controls acquisition of sodium tolerance is different from that mediating glucose regulation.

    PubMed

    Ye, Tian; Elbing, Karin; Hohmann, Stefan

    2008-09-01

    It recently became apparent that the highly conserved Snf1p protein kinase plays roles in controlling different cellular processes in the yeast Saccharomyces cerevisiae, in addition to its well-known function in glucose repression/derepression. We have previously reported that Snf1p together with Gis4p controls ion homeostasis by regulating expression of ENA1, which encodes the Ena1p Na(+) extrusion system. In this study we found that Snf1p is rapidly phosphorylated when cells are exposed to NaCl and this phosphorylation is required for the role of Snf1p in Na(+) tolerance. In contrast to activation by low glucose levels, the salt-induced phosphorylation of Snf1p promoted neither phosphorylation nor nuclear export of the Mig1p repressor. The mechanism that prevents Mig1p phosphorylation by active Snf1p under salt stress does not involve either hexokinase PII or the Gis4p regulator. Instead, Snf1p may mediate upregulation of ENA1 expression via the repressor Nrg1p. Activation of Snf1p in response to glucose depletion requires any of the three upstream protein kinases Sak1p, Tos3p and Elm1p, with Sak1p playing the most prominent role. The same upstream kinases were required for salt-induced Snf1p phosphorylation, and also under these conditions Sak1p played the most prominent role. Unexpectedly, however, it appears that Elm1p plays a dual role in acquisition of salt tolerance by activating Snf1p and in a presently unknown parallel pathway. Together, these results indicate that under salt stress Snf1p takes part in a different pathway from that during glucose depletion and this role is performed together as well as in parallel with its upstream kinase Elm1p. Snf1p appears to be part of a wider functional network than previously anticipated and the full complexity of this network remains to be elucidated.

  3. Multidimensional Separation Using HILIC and SCX Pre-fractionation for RP LC-MS/MS Platform with Automated Exclusion List-based MS Data Acquisition with Increased Protein Quantification

    PubMed Central

    Zhou, Yu; Meng, Zhen; Edman-Woolcott, Maria; Hamm-Alvarez, Sarah F; Zandi, Ebrahim

    2015-01-01

    Liquid chromatography–mass spectrometry (LC-MS) based proteomics is one of the most widely used analytical platforms for global protein discovery and quantification. One of the challenges is the difficulty of identifying low abundance biomarker proteins from limited biological samples. Extensive fractionation could expand proteomics dynamic range, however, at the cost of high sample and time consumption. Extensive fractionation would increase the sample need and the labeling cost. Also quantitative proteomics depending on high resolution MS have the limitation of spectral acquisition speed. Those practical problems hinder the in-depth quantitative proteomics analysis such as tandem mass tag (TMT) experiments. We found the joint use of hydrophilic interaction liquid chromatography (HILIC) and strong cation exchange Chromatography (SCX) prefractionation at medium level could improve MS/MS efficiency, increase proteome coverage, shorten analysis time and save valuable samples. In addition, we scripted a program, Exclusion List Convertor (ELC), which automates and streamlines data acquisition workflow using the precursor ion exclusion (PIE) method. PIE reduces redundancy of high abundance MS/MS analyses by running replicates of the sample. The precursor ions detected in the initial run(s) are excluded for MS/MS in the subsequent run. We compared PIE methods with standard data dependent acquisition (DDA) methods running replicates without PIE for their effectiveness in quantifying TMT-tagged peptides and proteins in mouse tears. We quantified a total of 845 proteins and 1401 peptides using the PIE workflow, while the DDA method only resulted in 347 proteins and 731 peptides. This represents a 144% increase of protein identifications as a result of PIE analysis. PMID:26807013

  4. Late Mitochondrial Acquisition, Really?

    PubMed Central

    Degli Esposti, Mauro

    2016-01-01

    This article provides a timely critique of a recent Nature paper by Pittis and Gabaldón that has suggested a late origin of mitochondria in eukaryote evolution. It shows that the inferred ancestry of many mitochondrial proteins has been incorrectly assigned by Pittis and Gabaldón to bacteria other than the aerobic proteobacteria from which the ancestor of mitochondria originates, thereby questioning the validity of their suggestion that mitochondrial acquisition may be a late event in eukaryote evolution. The analysis and approach presented here may guide future studies to resolve the true ancestry of mitochondria. PMID:27289097

  5. An Acquisition Guide for Executives

    EPA Pesticide Factsheets

    This guide covers the following subjects; What is Acquisition?, Purpose and Primary Functions of the Agency’s Acquisition System, Key Organizations in Acquisitions, Legal Framework, Key Players in Acquisitions, Acquisition Process, Acquisition Thresholds

  6. Syntax acquisition.

    PubMed

    Crain, Stephen; Thornton, Rosalind

    2012-03-01

    Every normal child acquires a language in just a few years. By 3- or 4-years-old, children have effectively become adults in their abilities to produce and understand endlessly many sentences in a variety of conversational contexts. There are two alternative accounts of the course of children's language development. These different perspectives can be traced back to the nature versus nurture debate about how knowledge is acquired in any cognitive domain. One perspective dates back to Plato's dialog 'The Meno'. In this dialog, the protagonist, Socrates, demonstrates to Meno, an aristocrat in Ancient Greece, that a young slave knows more about geometry than he could have learned from experience. By extension, Plato's Problem refers to any gap between experience and knowledge. How children fill in the gap in the case of language continues to be the subject of much controversy in cognitive science. Any model of language acquisition must address three factors, inter alia: 1. The knowledge children accrue; 2. The input children receive (often called the primary linguistic data); 3. The nonlinguistic capacities of children to form and test generalizations based on the input. According to the famous linguist Noam Chomsky, the main task of linguistics is to explain how children bridge the gap-Chomsky calls it a 'chasm'-between what they come to know about language, and what they could have learned from experience, even given optimistic assumptions about their cognitive abilities. Proponents of the alternative 'nurture' approach accuse nativists like Chomsky of overestimating the complexity of what children learn, underestimating the data children have to work with, and manifesting undue pessimism about children's abilities to extract information based on the input. The modern 'nurture' approach is often referred to as the usage-based account. We discuss the usage-based account first, and then the nativist account. After that, we report and discuss the findings of several

  7. Defense Acquisition Workforce Modernization

    DTIC Science & Technology

    2010-07-01

    Acquisition , Technology & Logistics, 2000). PBSA “involves acquisition strategies, methods, and techniques that describe and communicate measurable ... Acquisition Workforce Distribution of DoD Workforce and Attrition Rates Seperation Rates Distribution of Workforce by Years of Service 38 A final issue... measurement . 14 Provisions within the IMPROVE Act demand greater accountability from the acquisition workforce, improve financial management, expand

  8. Investigating Second Language Acquisition.

    ERIC Educational Resources Information Center

    Jordens, Peter, Ed.; Lalleman, Josine, Ed.

    Essays in second language acquisition include: "The State of the Art in Second Language Acquisition Research" (Josine Lalleman); "Crosslinguistic Influence with Special Reference to the Acquisition of Grammar" (Michael Sharwood Smith); "Second Language Acquisition by Adult Immigrants: A Multiple Case Study of Turkish and…

  9. Language Acquisition without an Acquisition Device

    ERIC Educational Resources Information Center

    O'Grady, William

    2012-01-01

    Most explanatory work on first and second language learning assumes the primacy of the acquisition phenomenon itself, and a good deal of work has been devoted to the search for an "acquisition device" that is specific to humans, and perhaps even to language. I will consider the possibility that this strategy is misguided and that language…

  10. EARLY SYNTACTIC ACQUISITION.

    ERIC Educational Resources Information Center

    KELLEY, K.L.

    THIS PAPER IS A STUDY OF A CHILD'S EARLIEST PRETRANSFORMATIONAL LANGUAGE ACQUISITION PROCESSES. A MODEL IS CONSTRUCTED BASED ON THE ASSUMPTIONS (1) THAT SYNTACTIC ACQUISITION OCCURS THROUGH THE TESTING OF HYPOTHESES REFLECTING THE INITIAL STRUCTURE OF THE ACQUISITION MECHANISM AND THE LANGUAGE DATA TO WHICH THE CHILD IS EXPOSED, AND (2) THAT…

  11. Role of the Carboxy Terminus of SecA in Iron Acquisition, Protein Translocation, and Virulence of the Bacterial Pathogen Acinetobacter baumannii

    PubMed Central

    Fiester, Steven E.; Nwugo, Chika C.; Penwell, William F.; Neary, John M.; Beckett, Amber C.; Arivett, Brock A.; Schmidt, Robert E.; Geiger, Sarah C.; Connerly, Pamela L.; Menke, Sharon M.; Tomaras, Andrew P.

    2015-01-01

    Acinetobacter baumannii is a Gram-negative opportunistic nosocomial pathogen that causes pneumonia and soft tissue and systemic infections. Screening of a transposon insertion library of A. baumannii ATCC 19606T resulted in the identification of the 2010 derivative, which, although capable of growing well in iron-rich media, failed to prosper under iron chelation. Genetic, molecular, and functional assays showed that 2010's iron utilization-deficient phenotype is due to an insertion within the 3′ end of secA, which results in the production of a C-terminally truncated derivative of SecA. SecA plays a critical role in protein translocation through the SecYEG membrane channel. Accordingly, the secA mutation resulted in undetectable amounts of the ferric acinetobactin outer membrane receptor protein BauA while not affecting the production of other acinetobactin membrane protein transport components, such as BauB and BauE, or the secretion of acinetobactin by 2010 cells cultured in the presence of subinhibitory concentrations of the synthetic iron chelator 2,2′-dipyridyl. Outer membrane proteins involved in nutrient transport, adherence, and biofilm formation were also reduced in 2010. The SecA truncation also increased production of 30 different proteins, including proteins involved in adaptation/tolerance responses. Although some of these protein changes could negatively affect the pathobiology of the 2010 derivative, its virulence defect is mainly due to its inability to acquire iron via the acinetobactin-mediated system. These results together indicate that although the C terminus of the A. baumannii ATCC 19606T SecA is not essential for viability, it plays a critical role in the production and translocation of different proteins and virulence. PMID:25605767

  12. Excessive acquisition in hoarding.

    PubMed

    Frost, Randy O; Tolin, David F; Steketee, Gail; Fitch, Kristin E; Selbo-Bruns, Alexandra

    2009-06-01

    Compulsive hoarding (the acquisition of and failure to discard large numbers of possessions) is associated with substantial health risk, impairment, and economic burden. However, little research has examined separate components of this definition, particularly excessive acquisition. The present study examined acquisition in hoarding. Participants, 878 self-identified with hoarding and 665 family informants (not matched to hoarding participants), completed an Internet survey. Among hoarding participants who met criteria for clinically significant hoarding, 61% met criteria for a diagnosis of compulsive buying and approximately 85% reported excessive acquisition. Family informants indicated that nearly 95% exhibited excessive acquisition. Those who acquired excessively had more severe hoarding; their hoarding had an earlier onset and resulted in more psychiatric work impairment days; and they experienced more symptoms of obsessive-compulsive disorder, depression, and anxiety. Two forms of excessive acquisition (buying and free things) each contributed independent variance in the prediction of hoarding severity and related symptoms.

  13. Software Acquisition Program Dynamics

    DTIC Science & Technology

    2011-10-24

    acquisition and development of software-reliant systems . Novak has more than 25 years of experience with real-time embedded software product development...Problem Poor acquisition program performance inhibits military performance by depriving the warfighter of critical systems to achieve mission...objectives • Delayed systems withhold needed capabilities • Wasted resources drain funding needed for new systems Acquisitions fail for both technical

  14. FTMP data acquisition environment

    NASA Technical Reports Server (NTRS)

    Padilla, Peter A.

    1988-01-01

    The Fault-Tolerant Multi-Processing (FTMP) test-bed data acquisition environment is described. The performance of two data acquisition devices available in the test environment are estimated and compared. These estimated data rates are used as measures of the devices' capabilities. A new data acquisition device was developed and added to the FTMP environment. This path increases the data rate available by approximately a factor of 8, to 379 KW/S, while simplifying the experiment development process.

  15. Streamlined acquisition handbook

    NASA Technical Reports Server (NTRS)

    1990-01-01

    NASA has always placed great emphasis on the acquisition process, recognizing it as among its most important activities. This handbook is intended to facilitate the application of streamlined acquisition procedures. The development of these procedures reflects the efforts of an action group composed of NASA Headquarters and center acquisition professionals. It is the intent to accomplish the real change in the acquisition process as a result of this effort. An important part of streamlining the acquisition process is a commitment by the people involved in the process to accomplishing acquisition activities quickly and with high quality. Too often we continue to accomplish work in 'the same old way' without considering available alternatives which would require no changes to regulations, approvals from Headquarters, or waivers of required practice. Similarly, we must be sensitive to schedule opportunities throughout the acquisition cycle, not just once the purchase request arrives at the procurement office. Techniques that have been identified as ways of reducing acquisition lead time while maintaining high quality in our acquisition process are presented.

  16. Coring Sample Acquisition Tool

    NASA Technical Reports Server (NTRS)

    Haddad, Nicolas E.; Murray, Saben D.; Walkemeyer, Phillip E.; Badescu, Mircea; Sherrit, Stewart; Bao, Xiaoqi; Kriechbaum, Kristopher L.; Richardson, Megan; Klein, Kerry J.

    2012-01-01

    A sample acquisition tool (SAT) has been developed that can be used autonomously to sample drill and capture rock cores. The tool is designed to accommodate core transfer using a sample tube to the IMSAH (integrated Mars sample acquisition and handling) SHEC (sample handling, encapsulation, and containerization) without ever touching the pristine core sample in the transfer process.

  17. Proteins.

    ERIC Educational Resources Information Center

    Doolittle, Russell F.

    1985-01-01

    Examines proteins which give rise to structure and, by virtue of selective binding to other molecules, make genes. Binding sites, amino acids, protein evolution, and molecular paleontology are discussed. Work with encoding segments of deoxyribonucleic acid (exons) and noncoding stretches (introns) provides new information for hypotheses. (DH)

  18. Protein

    MedlinePlus

    ... Search for: Harvard T.H. Chan School of Public Health Email People Departments Calendar Careers Give my.harvard ... Nutrition Source Harvard T.H. Chan School of Public Health > The Nutrition Source > What Should I Eat? > Protein ...

  19. Protein

    MedlinePlus

    ... Go lean with protein. • Choose lean meats and poultry. Lean beef cuts include round steaks (top loin, ... main dishes. • Use nuts to replace meat or poultry, not in addition to meat or poultry (i. ...

  20. The Biologist's Toolbox: Microcomputers in Biology: Data Acquisition.

    ERIC Educational Resources Information Center

    BioScience, 1985

    1985-01-01

    Discusses data acquisition systems for biologists, considering: (1) input; (2) output; (3) controllers; (4) software for data acquisition; and (5) programing languages. Also discusses several biochemical databases, including those storing data on protein sequences and on chemical structures in two-dimensional form (together with biological testing…

  1. Human target acquisition performance

    NASA Astrophysics Data System (ADS)

    Teaney, Brian P.; Du Bosq, Todd W.; Reynolds, Joseph P.; Thompson, Roger; Aghera, Sameer; Moyer, Steven K.; Flug, Eric; Espinola, Richard; Hixson, Jonathan

    2012-06-01

    The battlefield has shifted from armored vehicles to armed insurgents. Target acquisition (identification, recognition, and detection) range performance involving humans as targets is vital for modern warfare. The acquisition and neutralization of armed insurgents while at the same time minimizing fratricide and civilian casualties is a mounting concern. U.S. Army RDECOM CERDEC NVESD has conducted many experiments involving human targets for infrared and reflective band sensors. The target sets include human activities, hand-held objects, uniforms & armament, and other tactically relevant targets. This paper will define a set of standard task difficulty values for identification and recognition associated with human target acquisition performance.

  2. Interactive knowledge acquisition tools

    NASA Technical Reports Server (NTRS)

    Dudziak, Martin J.; Feinstein, Jerald L.

    1987-01-01

    The problems of designing practical tools to aid the knowledge engineer and general applications used in performing knowledge acquisition tasks are discussed. A particular approach was developed for the class of knowledge acquisition problem characterized by situations where acquisition and transformation of domain expertise are often bottlenecks in systems development. An explanation is given on how the tool and underlying software engineering principles can be extended to provide a flexible set of tools that allow the application specialist to build highly customized knowledge-based applications.

  3. Acquisitions for Area Programs

    ERIC Educational Resources Information Center

    Stevens, Robert D.

    1970-01-01

    Common policies, practices, and trends in acquisitions in the complex field of area studies, including the weak structure of the book trade, the lack of bibliographic control, and current cooperative efforts. (JS)

  4. Data acquisition system

    DOEpatents

    Shapiro, Stephen L.; Mani, Sudhindra; Atlas, Eugene L.; Cords, Dieter H. W.; Holbrook, Britt

    1997-01-01

    A data acquisition circuit for a particle detection system that allows for time tagging of particles detected by the system. The particle detection system screens out background noise and discriminate between hits from scattered and unscattered particles. The detection system can also be adapted to detect a wide variety of particle types. The detection system utilizes a particle detection pixel array, each pixel containing a back-biased PIN diode, and a data acquisition pixel array. Each pixel in the particle detection pixel array is in electrical contact with a pixel in the data acquisition pixel array. In response to a particle hit, the affected PIN diodes generate a current, which is detected by the corresponding data acquisition pixels. This current is integrated to produce a voltage across a capacitor, the voltage being related to the amount of energy deposited in the pixel by the particle. The current is also used to trigger a read of the pixel hit by the particle.

  5. Documentation and knowledge acquisition

    NASA Technical Reports Server (NTRS)

    Rochowiak, Daniel; Moseley, Warren

    1990-01-01

    Traditional approaches to knowledge acquisition have focused on interviews. An alternative focuses on the documentation associated with a domain. Adopting a documentation approach provides some advantages during familiarization. A knowledge management tool was constructed to gain these advantages.

  6. Army Acquisition Lessons Learned

    DTIC Science & Technology

    2014-10-01

    analysis on the lessons learned. Acquisition Lessons Learned Portal (ALLP) and Lessons Learned Collection CAALL has established the ALLP as the...PEOs) and their project offices, as well as the broader acquisition community. The primary function of the portal is to allow easy input and retrieval...download- able form that can be completed offline and then uploaded to the portal . This allows the form to be filled out and distrib- uted through

  7. Acquisition Support Program Overview

    DTIC Science & Technology

    2016-06-30

    Feedback from direct support and community learning improves ASP practices & SEI technologies © 2006 by Carnegie Mellon University page 6 ASP...the acquisition infrastructure throughout the DoD, Federal Agency and other acquirer communities . © 2006 by Carnegie Mellon University page 3...Seminars • Tailored learning via Acquisition Communities of Practice • Army, Navy, Air Force, Defense and Intel Agencies • Software Collaborator’s Network

  8. 75 FR 14057 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-40; Introduction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    ... Federal Acquisition Regulation; Federal Acquisition Circular 2005-40: Introduction, Small Entity... Acquisition Regulation; Federal Acquisition Circular 2005-40; Introduction AGENCIES: Department of Defense...

  9. Coordinating Council. Seventh Meeting: Acquisitions

    NASA Technical Reports Server (NTRS)

    1992-01-01

    The theme for this NASA Scientific and Technical Information Program Coordinating Council meeting was Acquisitions. In addition to NASA and the NASA Center for AeroSpace Information (CASI) presentations, the report contains fairly lengthy visuals about acquisitions at the Defense Technical Information Center. CASI's acquisitions program and CASI's proactive acquisitions activity were described. There was a presentation on the document evaluation process at CASI. A talk about open literature scope and coverage at the American Institute of Aeronautics and Astronautics was also given. An overview of the STI Program's Acquisitions Experts Committee was given next. Finally acquisitions initiatives of the NASA STI program were presented.

  10. Data Acquisition Backend

    SciTech Connect

    Britton Jr., Charles L.; Ezell, N. Dianne Bull; Roberts, Michael

    2013-10-01

    This document is intended to summarize the development and testing of the data acquisition module portion of the Johnson Noise Thermometry (JNT) system developed at ORNL. The proposed system has been presented in an earlier report [1]. A more extensive project background including the project rationale is available in the initial project report [2].

  11. Surviving mergers & acquisitions.

    PubMed

    Dixon, Diane L

    2002-01-01

    Mergers and acquisitions are never easy to implement. The health care landscape is a minefield of failed mergers and uneasy alliances generating great turmoil and pain. But some mergers have been successful, creating health systems that benefit the communities they serve. Five prominent leaders offer their advice on minimizing the difficulties of M&As.

  12. Autonomous Robot Skill Acquisition

    DTIC Science & Technology

    2011-05-01

    Research. ix ABSTRACT AUTONOMOUS ROBOT SKILL ACQUISITION MAY 2011 GEORGE DIMITRI KONIDARIS B.Sc., UNIVERSITY OF THE WITWATERSRAND B.Sc. Hons., UNIVERSITY...OF THE WITWATERSRAND M.Sc., UNIVERSITY OF EDINBURGH Ph.D., UNIVERSITY OF MASSACHUSETTS AMHERST Directed by: Professor Andrew G. Barto Among the most

  13. Acquisitions List No. 43.

    ERIC Educational Resources Information Center

    Planned Parenthood--World Population, New York, NY. Katherine Dexter McCormick Library.

    The "Acquisitions List" of demographic books and articles is issued every two months by the Katharine Dexter McCormick Library. Divided into two parts, the first contains a list of books most recently acquired by the Library, each one annotated and also marked with the Library call number. The second part consists of a list of annotated articles,…

  14. Acquisitions List No. 42.

    ERIC Educational Resources Information Center

    Planned Parenthood--World Population, New York, NY. Katherine Dexter McCormick Library.

    The "Acquisitions List" of demographic books and articles is issued every two months by the Katharine Dexter McCormick Library. Divided into two parts, the first contains a list of books most recently acquired by the Library, each one annotated and also marked with the Library call number. The second part consists of a list of annotated articles,…

  15. Telecommunications and data acquisition

    NASA Technical Reports Server (NTRS)

    Renzetti, N. A. (Editor)

    1981-01-01

    Deep Space Network progress in flight project support, tracking and data acquisition research and technology, network engineering, hardware and software implementation, and operations is reported. In addition, developments in Earth based radio technology as applied to geodynamics, astrophysics, and the radio search for extraterrestrial intelligence are reported.

  16. Acquisition of Comparison Constructions

    ERIC Educational Resources Information Center

    Hohaus, Vera; Tiemann, Sonja; Beck, Sigrid

    2014-01-01

    This article presents a study on the time course of the acquisition of comparison constructions. The order in which comparison constructions (comparatives, measure phrases, superlatives, degree questions, etc.) show up in English- and German-learning children's spontaneous speech is quite fixed. It is shown to be insufficiently determined by…

  17. Image Acquisition Context

    PubMed Central

    Bidgood, W. Dean; Bray, Bruce; Brown, Nicolas; Mori, Angelo Rossi; Spackman, Kent A.; Golichowski, Alan; Jones, Robert H.; Korman, Louis; Dove, Brent; Hildebrand, Lloyd; Berg, Michael

    1999-01-01

    Objective: To support clinically relevant indexing of biomedical images and image-related information based on the attributes of image acquisition procedures and the judgments (observations) expressed by observers in the process of image interpretation. Design: The authors introduce the notion of “image acquisition context,” the set of attributes that describe image acquisition procedures, and present a standards-based strategy for utilizing the attributes of image acquisition context as indexing and retrieval keys for digital image libraries. Methods: The authors' indexing strategy is based on an interdependent message/terminology architecture that combines the Digital Imaging and Communication in Medicine (DICOM) standard, the SNOMED (Systematized Nomenclature of Human and Veterinary Medicine) vocabulary, and the SNOMED DICOM microglossary. The SNOMED DICOM microglossary provides context-dependent mapping of terminology to DICOM data elements. Results: The capability of embedding standard coded descriptors in DICOM image headers and image-interpretation reports improves the potential for selective retrieval of image-related information. This favorably affects information management in digital libraries. PMID:9925229

  18. 78 FR 37164 - Land Acquisitions: Appeals of Land Acquisition Decisions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-20

    ...; Docket ID: BIA-2013-0005] RIN 1076-AF15 Land Acquisitions: Appeals of Land Acquisition Decisions AGENCY... applications to acquire land in trust under 25 CFR part 151. This document makes corrections to the...

  19. 48 CFR 7.401 - Acquisition considerations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Acquisition considerations. 7.401 Section 7.401 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING ACQUISITION PLANNING Equipment Lease or Purchase 7.401 Acquisition considerations....

  20. 33. Perimeter acquisition radar building room #320, perimeter acquisition radar ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    33. Perimeter acquisition radar building room #320, perimeter acquisition radar operations center (PAROC), contains the tactical command and control group equipment required to control the par site. Showing spacetrack monitor console - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

  1. The Acquisition of Serial Publications

    ERIC Educational Resources Information Center

    Huff, William H.

    1970-01-01

    Results of a questionnaire survey of large research libraries on procedures and special problems in serials acquisitions. Cooperative programs are discussed, including the Latin American Cooperative Acquisitions Program and the National Serials Data Program. (JS)

  2. 48 CFR 7.401 - Acquisition considerations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ACQUISITION PLANNING ACQUISITION PLANNING Equipment Lease or Purchase 7.401 Acquisition considerations. (a...) Financial and operating advantages of alternative types and makes of equipment. (3) Cumulative...

  3. Managing Radical Change in Acquisition

    DTIC Science & Technology

    1998-01-01

    some process innovation, acquisition continues to plague the Defense System and constrain battlefield mobility, information, and speed. Following the... System & Acquisition Management,Monterey,CA,93943 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES...Mark Nissen is Assistant Professor of Information Systems and Acquisition Management at the Naval Postgraduate School (NPS) in Monterey, CA. He

  4. Locative Terms and Warlpiri Acquisition.

    ERIC Educational Resources Information Center

    Bavin, Edith L.

    1990-01-01

    Focuses on the influence of language specific properties in the acquisition of locative expressions. Some of the claims from literature on the acquisition of locative expressions are discussed and data from the acquisition of Warlpiri are presented and discussed in terms of these claims. (Author/CB)

  5. Automatic carrier acquisition system

    NASA Technical Reports Server (NTRS)

    Bunce, R. C. (Inventor)

    1973-01-01

    An automatic carrier acquisition system for a phase locked loop (PLL) receiver is disclosed. It includes a local oscillator, which sweeps the receiver to tune across the carrier frequency uncertainty range until the carrier crosses the receiver IF reference. Such crossing is detected by an automatic acquisition detector. It receives the IF signal from the receiver as well as the IF reference. It includes a pair of multipliers which multiply the IF signal with the IF reference in phase and in quadrature. The outputs of the multipliers are filtered through bandpass filters and power detected. The output of the power detector has a signal dc component which is optimized with respect to the noise dc level by the selection of the time constants of the filters as a function of the sweep rate of the local oscillator.

  6. Data acquisition instruments: Psychopharmacology

    SciTech Connect

    Hartley, D.S. III

    1998-01-01

    This report contains the results of a Direct Assistance Project performed by Lockheed Martin Energy Systems, Inc., for Dr. K. O. Jobson. The purpose of the project was to perform preliminary analysis of the data acquisition instruments used in the field of psychiatry, with the goal of identifying commonalities of data and strategies for handling and using the data in the most advantageous fashion. Data acquisition instruments from 12 sources were provided by Dr. Jobson. Several commonalities were identified and a potentially useful data strategy is reported here. Analysis of the information collected for utility in performing diagnoses is recommended. In addition, further work is recommended to refine the commonalities into a directly useful computer systems structure.

  7. Materiel Acquisition Handbook. Revision

    DTIC Science & Technology

    1987-03-26

    Development Center director appoints the IPR chairman. The TPR chairman assenibles the IPR agenda pacl.age, staffs it within AMC, dIevelops the AL.C postion...to execute MADP agenda package recommendations. PPBES reviews must ensure recent materiel acquisition decisions are reflected and * supported. CHANGES... agenda packages must contain a notice that the package includes proposed changes to the requirements document, with supporting rationale as appropriate

  8. Getting Defense Acquisition Right

    DTIC Science & Technology

    2017-01-01

    Buying Power 1.0 Figure 2. Better Buying Power 2.0 Figure 3. Better Buying Power 3.0 179 Figure 4. Contract Cost Growth on Highest Risk (Major...Crossing Critical Congressional Cost- Growth Thresholds iv Getting Defense Acquisition Right 67 96 97 184 Table 1. Root...Causes for Major Programs Crossing Critical Con­ gressional Cost- Growth Thresholds or Other Major Problems 185 Figure 8. Planned Length of Active

  9. Advanced Data Acquisition Systems

    NASA Technical Reports Server (NTRS)

    Perotti, J.

    2003-01-01

    Current and future requirements of the aerospace sensors and transducers field make it necessary for the design and development of new data acquisition devices and instrumentation systems. New designs are sought to incorporate self-health, self-calibrating, self-repair capabilities, allowing greater measurement reliability and extended calibration cycles. With the addition of power management schemes, state-of-the-art data acquisition systems allow data to be processed and presented to the users with increased efficiency and accuracy. The design architecture presented in this paper displays an innovative approach to data acquisition systems. The design incorporates: electronic health self-check, device/system self-calibration, electronics and function self-repair, failure detection and prediction, and power management (reduced power consumption). These requirements are driven by the aerospace industry need to reduce operations and maintenance costs, to accelerate processing time and to provide reliable hardware with minimum costs. The project's design architecture incorporates some commercially available components identified during the market research investigation like: Field Programmable Gate Arrays (FPGA) Programmable Analog Integrated Circuits (PAC IC) and Field Programmable Analog Arrays (FPAA); Digital Signal Processing (DSP) electronic/system control and investigation of specific characteristics found in technologies like: Electronic Component Mean Time Between Failure (MTBF); and Radiation Hardened Component Availability. There are three main sections discussed in the design architecture presented in this document. They are the following: (a) Analog Signal Module Section, (b) Digital Signal/Control Module Section and (c) Power Management Module Section. These sections are discussed in detail in the following pages. This approach to data acquisition systems has resulted in the assignment of patent rights to Kennedy Space Center under U.S. patent # 6

  10. Data Acquisition Systems

    NASA Technical Reports Server (NTRS)

    1989-01-01

    Technology developed during a joint research program with Langley and Kinetic Systems Corporation led to Kinetic Systems' production of a high speed Computer Automated Measurement and Control (CAMAC) data acquisition system. The study, which involved the use of CAMAC equipment applied to flight simulation, significantly improved the company's technical capability and produced new applications. With Digital Equipment Corporation, Kinetic Systems is marketing the system to government and private companies for flight simulation, fusion research, turbine testing, steelmaking, etc.

  11. Defense ADP Acquisition Study.

    DTIC Science & Technology

    1981-11-30

    management issues. It also provides broad insight into the nature and causes of problems in the ADP acquisition process and offers several strategies ... strategy planning fails to provide the appropriate mission perspective. Curfent top-down strategic planning does not pro- vide the necessary guidance for the...recommendations presented here are more appropriately labeled strategies for change, rather than specific actions for improvement. (1) There Must Be a

  12. Second language acquisition.

    PubMed

    Juffs, Alan

    2011-05-01

    Second language acquisition (SLA) is a field that investigates child and adult SLA from a variety of theoretical perspectives. This article provides a survey of some key areas of concern including formal generative theory and emergentist theory in the areas of morpho-syntax and phonology. The review details the theoretical stance of the two different approaches to the nature of language: generative linguistics and general cognitive approaches. Some results of key acquisition studies from the two theoretical frameworks are discussed. From a generative perspective, constraints on wh-movement, feature geometry and syllable structure, and morphological development are highlighted. From a general cognitive point of view, the emergence of tense and aspect marking from a prototype account of inherent lexical aspect is reviewed. Reference is made to general cognitive learning theories and to sociocultural theory. The article also reviews individual differences research, specifically debate on the critical period in adult language acquisition, motivation, and memory. Finally, the article discusses the relationship between SLA research and second language pedagogy. Suggestions for further reading from recent handbooks on SLA are provided. WIREs Cogni Sci 2011 2 277-286 DOI: 10.1002/wcs.106 For further resources related to this article, please visit the WIREs website.

  13. Data acquisition with Masscomp

    SciTech Connect

    Collins, A.J.

    1988-12-31

    Applications and products for data acquisition and control are abundant. Systems and boards for Apple or IBM products collect, store, and manipulate data up to rates in the 10`s of thousands. These systems may suit your application; if so, it would be good for you to obtain one of these systems. However, if you need speed in the hundreds of thousands of samples per second and you want to store, process, and display data in real time, data acquisition becomes much more complex. Operating system code has to be sufficient to handle the load. A company known as Massachusetts Computer Corporation has modified UNIX operating system code to allow real time data acquisition and control. They call this operating system Real Time Unix, or RTU. They have built a family of computer systems around this operating system with specialized hardware to handle multiple processes and quick communications, which a real time operating system needs to function. This paper covers the basics of an application using a Masscomp 5520 computer. The application is for the KYLE Project Cold Tests in SRL. KYLE is a classified weapons program. The data flow from source to Masscomp, the generic features of Masscomp systems, and the specifics of the Masscomp computer related to this application will be presented.

  14. Complexity in language acquisition.

    PubMed

    Clark, Alexander; Lappin, Shalom

    2013-01-01

    Learning theory has frequently been applied to language acquisition, but discussion has largely focused on information theoretic problems-in particular on the absence of direct negative evidence. Such arguments typically neglect the probabilistic nature of cognition and learning in general. We argue first that these arguments, and analyses based on them, suffer from a major flaw: they systematically conflate the hypothesis class and the learnable concept class. As a result, they do not allow one to draw significant conclusions about the learner. Second, we claim that the real problem for language learning is the computational complexity of constructing a hypothesis from input data. Studying this problem allows for a more direct approach to the object of study--the language acquisition device-rather than the learnable class of languages, which is epiphenomenal and possibly hard to characterize. The learnability results informed by complexity studies are much more insightful. They strongly suggest that target grammars need to be objective, in the sense that the primitive elements of these grammars are based on objectively definable properties of the language itself. These considerations support the view that language acquisition proceeds primarily through data-driven learning of some form.

  15. Assessment of language acquisition.

    PubMed

    de Villiers, Peter A; de Villiers, Jill G

    2010-03-01

    This review addresses questions of what should be assessed in language acquisition, and how to do it. The design of a language assessment is crucially connected to its purpose, whether for diagnosis, development of an intervention plan, or for research. Precise profiles of language strengths and weaknesses are required for clear definitions of the phenotypes of particular language and neurodevelopmental disorders. The benefits and costs of formal tests versus language sampling assessments are reviewed. Content validity, theoretically and empirically grounded in child language acquisition, is claimed to be centrally important for appropriate assessment. Without this grounding, links between phenomena can be missed, and interpretations of underlying difficulties can be compromised. Sensitivity and specificity of assessment instruments are often assessed using a gold standard of existing tests and diagnostic practices, but problems arise if that standard is biased against particular groups or dialects. The paper addresses the issues raised by the goal of unbiased assessment of children from diverse linguistic and cultural backgrounds, especially speakers of non-mainstream dialects or bilingual children. A variety of new approaches are discussed for language assessment, including dynamic assessment, experimental tools such as intermodal preferential looking, and training studies that assess generalization. Stress is placed on the need for measures of the process of acquisition rather than just levels of achievement. Copyright © 2010 John Wiley & Sons, Ltd. For further resources related to this article, please visit the WIREs website.

  16. Development of the Health Literacy Assessment Scale for Adolescents (HAS-A)

    PubMed Central

    Manganello, Jennifer A.; DeVellis, Robert F.; Davis, Terry C.; Schottler-Thal, Carrin

    2016-01-01

    Background Health literacy has been found to be a crucial component of successful communication and navigation in health care. Various tools have been developed to measure health literacy skills, but few have been developed specifically for adolescents, and most require in-person administration. This study sought to develop a self-report health literacy scale for adolescents to assess four key health literacy domains: the ability to obtain, communicate, understand, and process health information. Methods We collected data from 272 youth aged 12–19 recruited from a pediatrics clinic (37%) and the community (63%). We administered the Rapid Estimate of Adolescent Literacy in Medicine-Teen, Newest Vital Sign, and three surveys, and used factor analysis to identify scale items. Results Using multiple health literacy assessments, it was clear that many teens struggle with low health literacy skills. When identifying items that can be used as self-report items in future research, factor analysis identified three subscales; a 5-item communication scale (alpha = 0.77), a 4-item confusion scale (alpha = 0.73), and a 6-item functional health literacy scale (alpha = 0.76). The scales performed reasonably well when compared with validation items. Conclusions Self-report items can be used to assess health literacy skills for adolescents when in-person administration is not possible or feasible. Such items will allow for greater study of how health literacy impacts communication in not only health care settings, but for all levels of health communication. The tool will also allow researchers to better understand how adolescent health literacy is related to a variety of health outcomes. Further testing of these scales with different populations is warranted. PMID:27656257

  17. 48 CFR 18.113 - Interagency acquisitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Interagency acquisitions. 18.113 Section 18.113 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Available Acquisition Flexibilities...

  18. 48 CFR 18.113 - Interagency acquisitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Interagency acquisitions. 18.113 Section 18.113 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Available Acquisition Flexibilities...

  19. 48 CFR 18.113 - Interagency acquisitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Interagency acquisitions. 18.113 Section 18.113 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Available Acquisition Flexibilities...

  20. 48 CFR 18.113 - Interagency acquisitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Interagency acquisitions. 18.113 Section 18.113 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Available Acquisition Flexibilities...

  1. Data acquisition system

    DOEpatents

    Phillips, David T.

    1979-01-01

    A data acquisition system capable of resolving transient pulses in the subnanosecond range. A pulse in an information carrying medium such as light is transmitted through means which disperse the pulse, such as a fiber optic light guide which time-stretches optical pulses by chromatic dispersion. This time-stretched pulse is used as a sampling pulse and is modulated by the signal to be recorded. The modulated pulse may be further time-stretched prior to being recorded. The recorded modulated pulse is unfolded to derive the transient signal by utilizing the relationship of the time-stretching that occurred in the original pulse.

  2. Acquisition-Management Program

    NASA Technical Reports Server (NTRS)

    Avery, Don E.; Vann, A. Vernon; Jones, Richard H.; Rew, William E.

    1987-01-01

    NASA Acquisition Management Subsystem (AMS) program integrated NASA-wide standard automated-procurement-system program developed in 1985. Designed to provide each NASA installation with procurement data-base concept with on-line terminals for managing, tracking, reporting, and controlling contractual actions and associated procurement data. Subsystem provides control, status, and reporting for various procurement areas. Purpose of standardization is to decrease costs of procurement and operation of automatic data processing; increases procurement productivity; furnishes accurate, on-line management information and improves customer support. Written in the ADABAS NATURAL.

  3. Data Acquisition Systems

    NASA Technical Reports Server (NTRS)

    1994-01-01

    In the mid-1980s, Kinetic Systems and Langley Research Center determined that high speed CAMAC (Computer Automated Measurement and Control) data acquisition systems could significantly improve Langley's ARTS (Advanced Real Time Simulation) system. The ARTS system supports flight simulation R&D, and the CAMAC equipment allowed 32 high performance simulators to be controlled by centrally located host computers. This technology broadened Kinetic Systems' capabilities and led to several commercial applications. One of them is General Atomics' fusion research program. Kinetic Systems equipment allows tokamak data to be acquired four to 15 times more rapidly. Ford Motor company uses the same technology to control and monitor transmission testing facilities.

  4. HYPERCP data acquisition system

    SciTech Connect

    Kaplan, D.M.; Luebke, W.R.; Chakravorty, A.

    1997-12-31

    For the HyperCP experiment at Fermilab, we have assembled a data acquisition system that records on up to 45 Exabyte 8505 tape drives in parallel at up to 17 MB/s. During the beam spill, data axe acquired from the front-end digitization systems at {approx} 60 MB/s via five parallel data paths. The front-end systems achieve typical readout deadtime of {approx} 1 {mu}s per event, allowing operation at 75-kHz trigger rate with {approx_lt}30% deadtime. Event building and tapewriting are handled by 15 Motorola MVME167 processors in 5 VME crates.

  5. Data-acquisition systems

    SciTech Connect

    Cyborski, D.R.; Teh, K.M.

    1995-08-01

    Up to now, DAPHNE, the data-acquisition system developed for ATLAS, was used routinely for experiments at ATLAS and the Dynamitron. More recently, the Division implemented 2 MSU/DAPHNE systems. The MSU/DAPHNE system is a hybrid data-acquisition system which combines the front-end of the Michigan State University (MSU) DA system with the traditional DAPHNE back-end. The MSU front-end is based on commercially available modules. This alleviates the problems encountered with the DAPHNE front-end which is based on custom designed electronics. The first MSU system was obtained for the APEX experiment and was used there successfully. A second MSU front-end, purchased as a backup for the APEX experiment, was installed as a fully-independent second MSU/DAPHNE system with the procurement of a DEC 3000 Alpha host computer, and was used successfully for data-taking in an experiment at ATLAS. Additional hardware for a third system was bought and will be installed. With the availability of 2 MSU/DAPHNE systems in addition to the existing APEX setup, it is planned that the existing DAPHNE front-end will be decommissioned.

  6. Unsupervised Language Acquisition

    NASA Astrophysics Data System (ADS)

    de Marcken, Carl

    1996-11-01

    This thesis presents a computational theory of unsupervised language acquisition, precisely defining procedures for learning language from ordinary spoken or written utterances, with no explicit help from a teacher. The theory is based heavily on concepts borrowed from machine learning and statistical estimation. In particular, learning takes place by fitting a stochastic, generative model of language to the evidence. Much of the thesis is devoted to explaining conditions that must hold for this general learning strategy to arrive at linguistically desirable grammars. The thesis introduces a variety of technical innovations, among them a common representation for evidence and grammars, and a learning strategy that separates the ``content'' of linguistic parameters from their representation. Algorithms based on it suffer from few of the search problems that have plagued other computational approaches to language acquisition. The theory has been tested on problems of learning vocabularies and grammars from unsegmented text and continuous speech, and mappings between sound and representations of meaning. It performs extremely well on various objective criteria, acquiring knowledge that causes it to assign almost exactly the same structure to utterances as humans do. This work has application to data compression, language modeling, speech recognition, machine translation, information retrieval, and other tasks that rely on either structural or stochastic descriptions of language.

  7. Manganese acquisition by Lactobacillus plantarum

    SciTech Connect

    Archibald, F.S.; Duong, M.N.

    1984-04-01

    Lactobacillus plantarum has an unusually high Mn(II) requirement for growth and accumulated over 30 mM intracellular Mn(II). The acquisition of Mn(II) by L. plantarum occurred via a specific active transport system powered by the transmembrane proton gradient. The Mn(II) uptake system has a K/sub m/ of 0.2 ..mu..M and a V/sub max/ of 24 nmol mg/sup -1/ of protein min/sup -1/. Above a medium Mn(II) concentration of 200 ..mu..M, the intracellular Mn(II) level was independent of the medium Mn(II) and unresponsive to oxygen stresses but was reduced by phosphate limitation. At a pH of 5.5, citrate, isocitrate, and cis-aconitate effectively promoted MN(II) uptake, although measurable levels of 1,5-(/sup 14/C)citrate were not accumulated. When cells were presented with equimolar Mn(II) and Cd(II), Cd(II) was preferentially taken up by the Mn(II) transport system. Both Mn(II) and Cd(II) uptake were greatly increased by Mn(II) starvation. Mn(II) uptake by Mn(II)-starved cells was subject to a negative feedback regulatory mechanism functioning less than 1 min after exposure of the cells to Mn(II) and independent of protein synthesis. When presented with a relatively large amount of exogenous Mn(II), Mn(II)-starved cells exhibited a measurable efflux of their internal Mn(II), but the rate was only a small fraction of the maximal Mn(II) uptake rate.

  8. 78 FR 32214 - Land Acquisitions: Appeals of Land Acquisition Decisions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-29

    ...; Docket ID: BIA-2013-0005] RIN 1076-AF15 Land Acquisitions: Appeals of Land Acquisition Decisions AGENCY... of regulations governing decisions by the Secretary to approve or deny applications to acquire land...'s decision to take the land into trust. The Supreme Court has since held that the Quiet Title...

  9. 78 FR 49990 - Land Acquisitions: Appeals of Land Acquisition Decisions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ...; Docket ID: BIA-2013-0005] RIN 1076-AF15 Land Acquisitions: Appeals of Land Acquisition Decisions AGENCY... governing decisions by the Secretary to approve or deny applications to acquire land in trust. The public... articulating the process for issuing decisions to acquire land in trust under 25 CFR part 151. The...

  10. Plasmid acquisition in microgravity

    NASA Technical Reports Server (NTRS)

    Juergensmeyer, Margaret A.; Juergensmeyer, Elizabeth A.; Guikema, James A.

    1995-01-01

    In microgravity, bacteria often show an increased resistance to antibiotics. Bacteria can develop resistance to an antibiotic after transformation, the acquisition of DNA, usually in the form of a plasmid containing a gene for resistance to one or more antibiotics. In order to study the capacity of bacteria to become resistant to antibiotics in microgravity, we have modified the standard protocol for transformation of Escherichia coli for use in the NASA-flight-certified hardware package, The Fluid Processing Apparatus (FPA). Here we report on the ability of E. coli to remain competent for long periods of time at temperatures that are readily available on the Space Shuttle, and present some preliminary flight results.

  11. Silicon tracker data acquisition

    SciTech Connect

    Haynes, W.J.

    1997-12-31

    Large particle physics experiments are making increasing technological demands on the design and implementation of real-time data acquisition systems. The LHC will have bunch crossing intervals of 25 nanoseconds and detectors, such as CMS, will contain over 10 million electronic channels. Readout systems will need to cope with 100 kHz rates of 1 MByte-sized events. Over 70% of this voluminous flow will stem from silicon tracker and MSGC devices. This paper describes the techniques currently being harnessed from ASIC devices through to modular microprocessor-based architectures around standards such as VMEbus and PCI. In particular, the experiences gained at the HERA H1 experiment are highlighted where many of the key technological concepts have already been im implemented.

  12. DSPS in data acquisition

    SciTech Connect

    Kirsch, M.; Haeupke, T.; Oelschlaeger, R.; Struck, B.

    1997-12-31

    Off-the-shelf and customized DSP boards in different bus architectures are perfectly suited to act as building blocks for flexible and high performance data acquisition systems. Due to their architecture they can be used to enhance the performance of existing equipment as add ons, as state-of-the-art readout controllers, event builders, on-the-fly data formatters and higher level trigger processors. Applications covering the above mentioned fields with Motorolas 96002 HARC DSP in the DESY HERMES and H1 experiments, at the focal plane polarimeter at KVI and the NIST high flux neutron backscattering spectrometer will be presented. Future possibilities with VME, PCI and PMC boards based on Analog Devices SHARC DSP will be discussed. Systems on the base of Texas Instruments TMS320C6X promise to provide unprecedented performance.

  13. Deepwater seismic acquisition technology

    SciTech Connect

    Caldwell, J.

    1996-09-01

    Although truly new technology is not required for successful acquisition of seismic data in deep Gulf of Mexico waters, it is helpful to review some basic aspects of these seismic surveys. Additionally, such surveys are likely to see early use of some emerging new technology which can improve data quality. Because such items as depth imaging, borehole seismic, 4-D and marine 3-component recording were mentioned in the May 1996 issue of World Oil, they are not discussed again here. However, these technologies will also play some role in the deepwater seismic activities. What is covered in this paper are some new considerations for: (1) longer data records needed in deeper water, (2) some pros and cons of very long steamer use, and (3) two new commercial systems for quantifying data quality.

  14. Universals of Second Language Acquisition.

    ERIC Educational Resources Information Center

    Eckman, Fred R., Ed.; And Others

    Works on second language acquisition theories, affective variables and communicative competence, and interlanguage were compiled as a result of a symposium on universals of second language acquisition at the University of Wisconsin, Milwaukee. The papers include: "On the Variability of Interlangauge Systems" (Elaine Tarone); "Memory, Learning, and…

  15. Microform Developments Related to Acquisitions.

    ERIC Educational Resources Information Center

    Sullivan, Robert C.

    1985-01-01

    Focuses on significant developments of the recent past in acquisition and control of library microforms. Highlights include reference works essential to acquisition of microforms and microform equipment, microform utilization in libraries, bibliographic control, computer output microfilm (COM) and the Copyright Law, technological developments,…

  16. Markedness and Second Language Acquisition.

    ERIC Educational Resources Information Center

    Gil-Byeon, Ja

    1999-01-01

    Discusses whether markedness is at work in second-language acquisition in the same way it is in first-language acquisition when Korean speakers learn English as a second language and English speakers learn Korean as a second language. Results are discussed in terms of no access to universal grammar, partial access to universal grammar, and access…

  17. Knowledge Acquisition in Observational Astronomy.

    ERIC Educational Resources Information Center

    Vosniadou, Stella

    This paper presents findings from research on knowledge acquisition in observational astronomy to demonstrate the kinds of intuitive models children form and to show how these models influence the acquisition of science knowledge. Sixty children of approximate ages 6, 9, and 12 were given a questionnaire to investigate their knowledge of the size,…

  18. Acquisition Policies. SPEC Kit 12.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This collection of acquisition materials from member libraries of the Association of Research Libraries (ARL) contains: (1) acquisition policies from Brigham Young University, Iowa State University, and the University of Cincinnati; (2) book selection policies from the University of Nebraska Undergraduate Library and Georgetown University; (3) an…

  19. Investment and Second Language Acquisition

    ERIC Educational Resources Information Center

    Pittaway, Daniel S.

    2004-01-01

    The article argues that Norton Peirce's (1995) concept of a language learner's investment should figure centrally in how instructors address the needs of adult learners in ESL classrooms. Investment is discussed in relation to second language acquisition research that addresses the role of social factors in second language acquisition. The article…

  20. STIS CCD Target Acquisition Workout

    NASA Astrophysics Data System (ADS)

    Downes, Ron

    1997-07-01

    Following update of STIS flight acquisitions and acq/peak software, redemonstrate the capability to perform point source and peakup acquisitions of a bright target. Then demonstrate ability of the STIS FSW to locate targets more typical of those in the science program.

  1. 48 CFR 207.401 - Acquisition considerations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Acquisition considerations. 207.401 Section 207.401 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... Acquisition considerations. If the equipment will be leased for more than 60 days, the requiring activity...

  2. 48 CFR 34.004 - Acquisition strategy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Acquisition strategy. 34... CATEGORIES OF CONTRACTING MAJOR SYSTEM ACQUISITION General 34.004 Acquisition strategy. The program manager, as specified in agency procedures, shall develop an acquisition strategy tailored to the...

  3. 48 CFR 3034.004 - Acquisition strategy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Acquisition strategy. 3034.004 Section 3034.004 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND... Acquisition strategy. See (HSAR) 48 CFR 3009.570 for policy applicable to acquisition strategies that...

  4. 48 CFR 873.105 - Acquisition planning.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Acquisition planning. 873.105 Section 873.105 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS DEPARTMENT... planning. (a) Acquisition planning is an indispensable component of the total acquisition process. (b)...

  5. 48 CFR 873.105 - Acquisition planning.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SUPPLEMENTARY REGULATIONS SIMPLIFIED ACQUISITION PROCEDURES FOR HEALTH-CARE RESOURCES 873.105 Acquisition... the acquisition of health-care resources consisting of commercial services or the use of medical equipment or space, where the acquisition is expected to exceed the simplified acquisition threshold...

  6. 48 CFR 234.004 - Acquisition strategy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Acquisition strategy. 234..., DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING MAJOR SYSTEM ACQUISITION 234.004 Acquisition strategy. (1) See 209.570 for policy applicable to acquisition strategies that consider the use of lead...

  7. Ocean Data Acquisition System

    NASA Technical Reports Server (NTRS)

    Johnson, B.; Cavanaugh, J.; Smith, J.; Esaias, W.

    1988-01-01

    The Ocean Data Acquisition System (ODAS) is a low cost instrument with potential commercial application. It is easily mounted on a small aircraft and flown over the coastal zone ocean to remotely measure sea surface temperature and three channels of ocean color information. From this data, chlorophyll levels can be derived for use by ocean scientists, fisheries, and environmental offices. Data can be transmitted to shipboard for real-time use with sea truth measurements, ocean productivity estimates and fishing fleet direction. The aircraft portion of the system has two primary instruments: an IR radiometer to measure sea surface temperature and a three channel visible spectro-radiometer for 460, 490, and 520 nm wavelength measurements from which chlorophyll concentration can be derived. The aircraft package contains a LORAN-C unit for aircraft location information, clock, on-board data processor and formatter, digital data storage, packet radio terminal controller, and radio transceiver for data transmission to a ship. The shipboard package contains a transceiver, packet terminal controller, data processing and storage capability, and printer. Both raw data and chlorophyll concentrations are available for real-time analysis.

  8. Processes Asunder: Acquisition & Planning Misfits

    DTIC Science & Technology

    2009-03-26

    St ra te gy Re se ar ch Pr oj ec t PROCESSES ASUNDER: ACQUISITION & PLANNING MISFITS BY CHÉRIE A. SMITH Department of Army Civilian DISTRIBUTION...Asunder: Acquisition & Planning Misfits 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Chérie A. Smith 5d. PROJECT NUMBER 5e...include area code) Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std. Z39.18 USAWC STRATEGY RESEARCH PROJECT PROCESSES ASUNDER: ACQUISITION & PLANNING

  9. Space storable propellant acquisition system

    NASA Technical Reports Server (NTRS)

    Tegart, J. R.; Uney, P. E.; Anderson, J. E.; Fester, D. A.

    1972-01-01

    Surface tension propellant acquisition concepts for an advanced spacecraft propulsion system having a 10-year mission capability were investigated. Surface tension systems were specified because they were shown to be the best propellant acquisition technique for various interplanetery spacecraft in a prior study. A variety of surface tension concepts for accomplishing propellant acquisition were formulated for the baseline space storable propulsion module and Jupiter Orbiter mission. Analyses and evaluations were then conducted on each candidate concept to assess fabricability, performance capability, and spacecraft compatibility. A comparative evaluation of the results showed the Fruhof-class of low-g surface tension systems to be preferred for these interplanetary applications.

  10. Automated ship image acquisition

    NASA Astrophysics Data System (ADS)

    Hammond, T. R.

    2008-04-01

    The experimental Automated Ship Image Acquisition System (ASIA) collects high-resolution ship photographs at a shore-based laboratory, with minimal human intervention. The system uses Automatic Identification System (AIS) data to direct a high-resolution SLR digital camera to ship targets and to identify the ships in the resulting photographs. The photo database is then searchable using the rich data fields from AIS, which include the name, type, call sign and various vessel identification numbers. The high-resolution images from ASIA are intended to provide information that can corroborate AIS reports (e.g., extract identification from the name on the hull) or provide information that has been omitted from the AIS reports (e.g., missing or incorrect hull dimensions, cargo, etc). Once assembled into a searchable image database, the images can be used for a wide variety of marine safety and security applications. This paper documents the author's experience with the practicality of composing photographs based on AIS reports alone, describing a number of ways in which this can go wrong, from errors in the AIS reports, to fixed and mobile obstructions and multiple ships in the shot. The frequency with which various errors occurred in automatically-composed photographs collected in Halifax harbour in winter time were determined by manual examination of the images. 45% of the images examined were considered of a quality sufficient to read identification markings, numbers and text off the entire ship. One of the main technical challenges for ASIA lies in automatically differentiating good and bad photographs, so that few bad ones would be shown to human users. Initial attempts at automatic photo rating showed 75% agreement with manual assessments.

  11. The acquisition of syntactic knowledge

    SciTech Connect

    Berwick, R.

    1985-01-01

    This work in computational linguistics describes a break-through in the design of expert systems because it suggests how extensive knowledge might be acquired automatically, without outside intervention. Computationally, the author looks at the developmental problem of the interaction between innate genetic endowment and environmental input, using computational methods to uncover the constraints on the acquisition of syntactic knowledge. Learning and syntax problems are also explored: how lexical categories, phonological rule systems, and phrase structure rules are learned; the role of semantic-syntactic interaction in language acquisition; how a ''parameter setting'' model may be formalized as a learning procedure; how multiple constraints interact to aid acquisition; how transformational-type rules may be learned; and the role of lexical ambiguity in language acquisition.

  12. Acquisition of Books and Pamphlets

    ERIC Educational Resources Information Center

    Thompson, Lawrence S.

    1970-01-01

    Acquisitions of current printed works in the research library is a complex process because of the proliferation of publishers and publications in all subject areas. Cooperation among the librarian, subject specialist, and dealers is necessary. (JS)

  13. Acquisition Activities in Intensive Reading.

    ERIC Educational Resources Information Center

    Zhenghua, Xu

    1998-01-01

    Discusses four possible ways to conduct language-acquisition activities in the foreign-language classroom: (1) vivid linking; (2) story retelling; (3) self-directed statement; and (4) role playing. (Author/VWL)

  14. Schizophrenia and second language acquisition.

    PubMed

    Bersudsky, Yuly; Fine, Jonathan; Gorjaltsan, Igor; Chen, Osnat; Walters, Joel

    2005-05-01

    Language acquisition involves brain processes that can be affected by lesions or dysfunctions in several brain systems and second language acquisition may depend on different brain substrates than first language acquisition in childhood. A total of 16 Russian immigrants to Israel, 8 diagnosed schizophrenics and 8 healthy immigrants, were compared. The primary data for this study were collected via sociolinguistic interviews. The two groups use language and learn language in very much the same way. Only exophoric reference and blocking revealed meaningful differences between the schizophrenics and healthy counterparts. This does not mean of course that schizophrenia does not induce language abnormalities. Our study focuses on those aspects of language that are typically difficult to acquire in second language acquisition. Despite the cognitive compromises in schizophrenia and the manifest atypicalities in language of speakers with schizophrenia, the process of acquiring a second language seems relatively unaffected by schizophrenia.

  15. STIS Target Acquisitions During SMOV

    NASA Astrophysics Data System (ADS)

    Katsanis, Rocio M.; Downes, Ron; Hartig, George; Kraemer, Steve

    1997-07-01

    We summarize the first results on the analysis of in-flight STIS target acquisition (ACQ and ACQ/PEAK). These results show that the STIS target acquisition (ACQ) is working very accurately for point sources (within 0.5 pixels = 0.025 arcseconds), about 4 times better than specified in the Instrument Handbook. As a result of the accuracy of the ACQ algorithm, we are no longer recommending to perform ACQ/PEAKs for the 0.2 arcsecond wide slits. For diffuse acquisitions the accuracy varies with target size. Although analysis of ACQ/PEAK data is hampered by a flight software problem, we anticipate that peakups will be accurate to roughly ±5% of the slit width (instead of the ±15% pr eviously advertised). We are implementing several enhancements to the flight software that will take effect by mid- August to improve the quality of the acquisitions.

  16. An Analysis of Army Rapid Acquisition

    DTIC Science & Technology

    2015-09-01

    Strategy ........54 6. Value Center Six: Life Cycle Costs ............................................54 7. Value Center Seven: Lessons Learned...information assurance strategy ANPP Apple new product process AOA analysis of alternatives APB acquisition program baseline APC acquisition program...candidate APO Army Project Office APUC average procurement unit cost AS acquisition strategy ASOM acquisition system operating model BBP better

  17. 48 CFR 1318.270 - Emergency acquisition flexibilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... flexibilities. 1318.270 Section 1318.270 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Emergency Acquisition Flexibilities 1318.270 Emergency acquisition flexibilities. (a) Authorizing emergency acquisition flexibilities. The process...

  18. 48 CFR 1318.270 - Emergency acquisition flexibilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... flexibilities. 1318.270 Section 1318.270 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Emergency Acquisition Flexibilities 1318.270 Emergency acquisition flexibilities. (a) Authorizing emergency acquisition flexibilities. The process...

  19. 48 CFR 1318.270 - Emergency acquisition flexibilities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... flexibilities. 1318.270 Section 1318.270 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Emergency Acquisition Flexibilities 1318.270 Emergency acquisition flexibilities. (a) Authorizing emergency acquisition flexibilities. The process...

  20. 48 CFR 1318.270 - Emergency acquisition flexibilities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... flexibilities. 1318.270 Section 1318.270 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Emergency Acquisition Flexibilities 1318.270 Emergency acquisition flexibilities. (a) Authorizing emergency acquisition flexibilities. The process...

  1. 48 CFR 1318.270 - Emergency acquisition flexibilities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... flexibilities. 1318.270 Section 1318.270 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Emergency Acquisition Flexibilities 1318.270 Emergency acquisition flexibilities. (a) Authorizing emergency acquisition flexibilities. The process...

  2. 48 CFR Appendix - Federal Acquisition Regulation (FAR) Index

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Federal Acquisition Regulation (FAR) Index Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT... (IFMS) Contract clause. FAR Index Federal Acquisition Regulation (FAR) Index Editorial Note:...

  3. 48 CFR Appendix - Federal Acquisition Regulation (FAR) Index

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Federal Acquisition Regulation (FAR) Index Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT... (IFMS) Contract clause. FAR Index Federal Acquisition Regulation (FAR) Index Editorial Note:...

  4. Iron acquisition by Cryptococcus neoformans.

    PubMed

    Vartivarian, S E; Cowart, R E; Anaissie, E J; Tashiro, T; Sprigg, H A

    1995-01-01

    Iron is an essential element for the growth and metabolism of microbial cells. Most pathogenic microbes elaborate powerful iron chelating agents (siderophores) to mobilize iron from ferric ligands. The pathogenic yeast, Cryptococcus neoformans has not been found to produce siderophores and its mechanism of iron acquisition is unknown. This investigation explored an alternative pathway for iron acquisition by examining the interactions of iron with the cell surface. Iron uptake experiments were conducted utilizing radiolabelled ferrous iron and ferric iron chelates, with evidence for the presence of iron(II) receptors and the generation of ferrous iron by surface reduction. Hyperbolic kinetics were found when 59FeII was presented to the organism and uptake was blocked with bathophenanthroline sulphonate, an Fe2+ chelator. The yeast also acquired iron as [59Fe3+]-citrate and [59Fe3+]-pyrophosphate while bathophenanthroline sulphonate reduced the acquisition of these ferric ligands by 48% and 52% respectively. Pre-incubation with either ferric ligand also reduced iron acquisition by 50%. KCN inhibited uptake of iron(II) by 90% and uptake of [59Fe3+]-pyrophosphate and [59Fe3+]-citrate by 46% and 56% respectively; dinitrophenol had no effect on these processes. The data suggest that C. neoformans can (i) generate ferrous iron at the cell surface via a reduction of ferric chelates, with the subsequent acquisition of the ferrous iron, and (ii) acquire iron through the interaction of ferric chelates with a surface component.

  5. Space Acquisitions: Challenges Facing DOD as it Changes Approaches to Space Acquisitions

    DTIC Science & Technology

    2016-03-09

    SPACE ACQUISITIONS Challenges Facing DOD as it Changes Approaches to Space Acquisitions Statement of Cristina T. Chaplain...2016 SPACE ACQUISITIONS Challenges Facing DOD as it Changes Approaches to Space Acquisitions Why GAO Did This Study DOD is shifting its traditional...approach to space acquisitions, bolstering its protection of space systems, and engaging with more commercial providers. Given the time and

  6. Computational models of syntactic acquisition.

    PubMed

    Yang, Charles

    2012-03-01

    The computational approach to syntactic acquisition can be fruitfully pursued by integrating results and perspectives from computer science, linguistics, and developmental psychology. In this article, we first review some key results in computational learning theory and their implications for language acquisition. We then turn to examine specific learning models, some of which exploit distributional information in the input while others rely on a constrained space of hypotheses, yet both approaches share a common set of characteristics to overcome the learning problem. We conclude with a discussion of how computational models connects with the empirical study of child grammar, making the case for computationally tractable, psychologically plausible and developmentally realistic models of acquisition. WIREs Cogn Sci 2012, 3:205-213. doi: 10.1002/wcs.1154 For further resources related to this article, please visit the WIREs website.

  7. Acquisition Reform: Three Big Ideas

    DTIC Science & Technology

    2015-05-19

    Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Three Acq Reform Big Ideas 5 /19/2015 2 (1) Competing Capability Needs Among Services...to sponsor and users • Not required to be an acquisition expert • Tenure not as important Summary: 3 Big Ideas 5 /19/2015 19 (1) Competing...Acquisition Reform Three Big Ideas The provocative views expressed here are not those of the Department of Defense, DAU, or perhaps even the

  8. Stochastic reinforcement benefits skill acquisition.

    PubMed

    Dayan, Eran; Averbeck, Bruno B; Richmond, Barry J; Cohen, Leonardo G

    2014-02-14

    Learning complex skills is driven by reinforcement, which facilitates both online within-session gains and retention of the acquired skills. Yet, in ecologically relevant situations, skills are often acquired when mapping between actions and rewarding outcomes is unknown to the learning agent, resulting in reinforcement schedules of a stochastic nature. Here we trained subjects on a visuomotor learning task, comparing reinforcement schedules with higher, lower, or no stochasticity. Training under higher levels of stochastic reinforcement benefited skill acquisition, enhancing both online gains and long-term retention. These findings indicate that the enhancing effects of reinforcement on skill acquisition depend on reinforcement schedules.

  9. CRISPR adaptation biases explain preference for acquisition of foreign DNA.

    PubMed

    Levy, Asaf; Goren, Moran G; Yosef, Ido; Auster, Oren; Manor, Miriam; Amitai, Gil; Edgar, Rotem; Qimron, Udi; Sorek, Rotem

    2015-04-23

    CRISPR-Cas (clustered, regularly interspaced short palindromic repeats coupled with CRISPR-associated proteins) is a bacterial immunity system that protects against invading phages or plasmids. In the process of CRISPR adaptation, short pieces of DNA ('spacers') are acquired from foreign elements and integrated into the CRISPR array. So far, it has remained a mystery how spacers are preferentially acquired from the foreign DNA while the self chromosome is avoided. Here we show that spacer acquisition is replication-dependent, and that DNA breaks formed at stalled replication forks promote spacer acquisition. Chromosomal hotspots of spacer acquisition were confined by Chi sites, which are sequence octamers highly enriched on the bacterial chromosome, suggesting that these sites limit spacer acquisition from self DNA. We further show that the avoidance of self is mediated by the RecBCD double-stranded DNA break repair complex. Our results suggest that, in Escherichia coli, acquisition of new spacers largely depends on RecBCD-mediated processing of double-stranded DNA breaks occurring primarily at replication forks, and that the preference for foreign DNA is achieved through the higher density of Chi sites on the self chromosome, in combination with the higher number of forks on the foreign DNA. This model explains the strong preference to acquire spacers both from high copy plasmids and from phages.

  10. 75 FR 1567 - Defense Federal Acquisition Regulation Supplement; Foreign Participation in Acquisitions in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 225 and 252 Defense Federal Acquisition Regulation Supplement; Foreign Participation in Acquisitions in Support of Operations in Afghanistan AGENCY:...

  11. 75 FR 19167 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-41; Introduction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... Federal Acquisition Regulations; Federal Acquisition Circular 2005-41; Introduction; FAR Case 2009-005... Acquisition Circular 2005-41; Introduction AGENCIES: Department of Defense (DoD), General...

  12. 76 FR 30362 - Federal Acquisition Regulation; Submission for OMB Review; Acquisition of Helium

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ...; Submission for OMB Review; Acquisition of Helium AGENCY: Department of Defense (DOD), General Services... approved information collection requirement concerning acquisition of helium. Public comments are... Collection 9000- 0113, Acquisition of Helium, by any of the following methods: Regulations.gov :...

  13. Data Acquisition for Modular Biometric Monitoring System

    NASA Technical Reports Server (NTRS)

    Chmiel, Alan J. (Inventor); Humphreys, Bradley T. (Inventor); Grodsinsky, Carlos M. (Inventor)

    2014-01-01

    A modular system for acquiring biometric data includes a plurality of data acquisition modules configured to sample biometric data from at least one respective input channel at a data acquisition rate. A representation of the sampled biometric data is stored in memory of each of the plurality of data acquisition modules. A central control system is in communication with each of the plurality of data acquisition modules through a bus. The central control system is configured to collect data asynchronously, via the bus, from the memory of the plurality of data acquisition modules according to a relative fullness of the memory of the plurality of data acquisition modules.

  14. 76 FR 10476 - (General Provisions) Contract Appeals and the Acquisition Regulation: General, Acquisition...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-25

    ... 1991-AB81 (General Provisions) Contract Appeals and the Acquisition Regulation: General, Acquisition Planning, and Contracting Methods and Contract Types Correction In rule document 2011-1320 appearing...

  15. Language Acquisition and Language Revitalization

    ERIC Educational Resources Information Center

    O'Grady, William; Hattori, Ryoko

    2016-01-01

    Intergenerational transmission, the ultimate goal of language revitalization efforts, can only be achieved by (re)establishing the conditions under which an imperiled language can be acquired by the community's children. This paper presents a tutorial survey of several key points relating to language acquisition and maintenance in children,…

  16. Analog Input Data Acquisition Software

    NASA Technical Reports Server (NTRS)

    Arens, Ellen

    2009-01-01

    DAQ Master Software allows users to easily set up a system to monitor up to five analog input channels and save the data after acquisition. This program was written in LabVIEW 8.0, and requires the LabVIEW runtime engine 8.0 to run the executable.

  17. Lexical Constraints on Syntactic Acquisition.

    ERIC Educational Resources Information Center

    Ard, Josh; Gass, Susan M.

    1987-01-01

    Data from responses to a grammaticality judgement test by 26 learners of English as a second language at two proficiency levels were used to investigate syntactic acquisition. Four syntactic structures were examined. Results suggest that less proficient subjects use syntactic strategies, while more proficient learners use semantic-based…

  18. Soviet Weapon-System Acquisition

    DTIC Science & Technology

    1991-09-01

    available in theIWest, provides the central coordination and policy guidance for Soviet weapons acquisition and oversees all military-related research...Machine Building Nuclear weapons and high- (MISREDMASH), (MSM) energy lasers i Ministry of Ship Building Naval vessels and naval (MINSUDPROM), (MSP) weapons...MINRADPROM), (MRP) equipment, guidance -and- control systems, navigation 3 equipment, and military computers Ministry of Communications

  19. Acquisition streamlining: A cultural change

    NASA Technical Reports Server (NTRS)

    Stewart, Jesse

    1992-01-01

    The topics are presented in viewgraph form and include the following: the defense systems management college, educational philosophy, the defense acquisition environment, streamlining initiatives, organizational streamlining types, defense law review, law review purpose, law review objectives, the Public Law Pilot Program, and cultural change.

  20. Bilingualism and Third Language Acquisition.

    ERIC Educational Resources Information Center

    Garate, Jose Valencia; Iragui, Jasone Cenoz

    A study investigated the role of bilingualism (Basque/Spanish) and motivation in third (English) language acquisition in Spain's Basque country. Subjects were 321 secondary school students in two programs, one with instruction primarily in Spanish and one with instruction primarily in Basque. The following independent variables were analyzed in…

  1. Soviet Studies in Language Acquisition

    ERIC Educational Resources Information Center

    Smith, Paul R., Jr.

    1973-01-01

    Article surveys the special theories and empirical studies of language acquisition carried out by Soviet psychologists, especially in the period since 1950. The basic principles of materialism, historicism and social reference characteristic of Soviet Marxist psychology are placed in contrast to certain current tendencies in American linguistics.…

  2. Defense Acquisition Performance Assessment Report

    DTIC Science & Technology

    2006-01-01

    DAPA Project Officer” BeCKeR, gRACe CHuNg , Associate Deputy General Counsel, Office of the Secretary of Defense – “Legal view of the Processes...FiguRes Jordan, Dr. Leland G. “Systemic Fiscal Optimism in Defense Planning.” Acquisition Review Quarterly Winter 2000: 47-62. Joyce, Michael and Bettina

  3. Bootstrapping Lexical and Syntactic Acquisition

    ERIC Educational Resources Information Center

    Christophe, Anne; Millotte, Severine; Bernal, Savita; Lidz, Jeffrey

    2008-01-01

    This paper focuses on how phrasal prosody and function words may interact during early language acquisition. Experimental results show that infants have access to intermediate prosodic phrases (phonological phrases) during the first year of life, and use these to constrain lexical segmentation. These same intermediate prosodic phrases are used by…

  4. Buffer Gas Acquisition and Storage

    NASA Technical Reports Server (NTRS)

    Parrish, Clyde F.; Lueck, Dale E.; Jennings, Paul A.; Callahan, Richard A.; Delgado, H. (Technical Monitor)

    2001-01-01

    The acquisition and storage of buffer gases (primarily argon and nitrogen) from the Mars atmosphere provides a valuable resource for blanketing and pressurizing fuel tanks and as a buffer gas for breathing air for manned missions. During the acquisition of carbon dioxide (CO2), whether by sorption bed or cryo-freezer, the accompanying buffer gases build up in the carbon dioxide acquisition system, reduce the flow of CO2 to the bed, and lower system efficiency. It is this build up of buffer gases that provide a convenient source, which must be removed, for efficient capture Of CO2 Removal of this buffer gas barrier greatly improves the charging rate of the CO2 acquisition bed and, thereby, maintains the fuel production rates required for a successful mission. Consequently, the acquisition, purification, and storage of these buffer gases are important goals of ISRU plans. Purity of the buffer gases is a concern e.g., if the CO, freezer operates at 140 K, the composition of the inert gas would be approximately 21 percent CO2, 50 percent nitrogen, and 29 percent argon. Although there are several approaches that could be used, this effort focused on a hollow-fiber membrane (HFM) separation method. This study measured the permeation rates of CO2, nitrogen (ND, and argon (Ar) through a multiple-membrane system and the individual membranes from room temperature to 193K and 10 kpa to 300 kPa. Concentrations were measured with a gas chromatograph that used a thermoconductivity (TCD) detector with helium (He) as the carrier gas. The general trend as the temperature was lowered was for the membranes to become more selective, In addition, the relative permeation rates between the three gases changed with temperature. The end result was to provide design parameters that could be used to separate CO2 from N2 and Ar.

  5. Buffer gas acquisition and storage

    NASA Astrophysics Data System (ADS)

    Parrish, Clyde F.; Lueck, Dale E.; Jennings, Paul A.

    2001-02-01

    The acquisition and storage of buffer gases (primarily argon and nitrogen) from the Mars atmosphere provides a valuable resource for blanketing and pressurizing fuel tanks and as a buffer gas for breathing air for manned missions. During the acquisition of carbon dioxide (CO2), whether by sorption bed or cryo-freezer, the accompanying buffer gases build up in the carbon dioxide acquisition system, reduce the flow of CO2 to the bed, and lower system efficiency. It is this build up of buffer gases that provide a convenient source, which must be removed, for efficient capture of CO2. Removal of this buffer gas barrier greatly improves the charging rate of the CO2 acquisition bed and, thereby, maintains the fuel production rates required for a successful mission. Consequently, the acquisition, purification, and storage of these buffer gases are important goals of ISRU plans. Purity of the buffer gases is a concern e.g., if the CO2 freezer operates at 140 K, the composition of the inert gas would be approximately 21 percent CO2, 50 percent nitrogen, and 29 percent argon. Although there are several approaches that could be used, this effort focused on a hollow-fiber membrane (HFM) separation method. This study measured the permeation rates of CO2, nitrogen (N2), and argon (Ar) through a multiple-membrane system and the individual membranes from room temperature to 193 K and 10 kPa to 300 kPa. Concentrations were measured with a gas chromatograph. The end result was data necessary to design a system that could separate CO2, N2, and Ar. .

  6. 48 CFR 307.104-70 - Acquisition strategy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Acquisition strategy. 307... AND ACQUISITION PLANNING ACQUISITION PLANNING Acquisition Planning 307.104-70 Acquisition strategy... designated by the HHS CIO, DASFMP, the CAO, or the cognizant HCA) shall prepare an acquisition strategy...

  7. 48 CFR 218.170 - Additional acquisition flexibilities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Additional acquisition flexibilities. 218.170 Section 218.170 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... Acquisition Flexibilities 218.170 Additional acquisition flexibilities. Additional acquisition...

  8. 48 CFR 218.170 - Additional acquisition flexibilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Additional acquisition flexibilities. 218.170 Section 218.170 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... Acquisition Flexibilities 218.170 Additional acquisition flexibilities. Additional acquisition...

  9. 48 CFR 218.170 - Additional acquisition flexibilities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Additional acquisition flexibilities. 218.170 Section 218.170 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... Acquisition Flexibilities 218.170 Additional acquisition flexibilities. Additional acquisition...

  10. 48 CFR 218.170 - Additional acquisition flexibilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Additional acquisition flexibilities. 218.170 Section 218.170 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... Acquisition Flexibilities 218.170 Additional acquisition flexibilities. Additional acquisition...

  11. 48 CFR 218.170 - Additional acquisition flexibilities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Additional acquisition flexibilities. 218.170 Section 218.170 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... Acquisition Flexibilities 218.170 Additional acquisition flexibilities. Additional acquisition...

  12. 48 CFR 434.004 - Acquisition strategy.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... manager will develop, in coordination with the Acquisition Executive or Major Information Technology... approval of the Acquisition Executive or Major Information Technology Systems Executive, a project control... Executive or Major Information Technology Systems Executive. (d) Specific procedures and requirements...

  13. 48 CFR 434.004 - Acquisition strategy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... manager will develop, in coordination with the Acquisition Executive or Major Information Technology... approval of the Acquisition Executive or Major Information Technology Systems Executive, a project control... Executive or Major Information Technology Systems Executive. (d) Specific procedures and requirements...

  14. 32 CFR 644.7 - Acquisition lines.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... HANDBOOK Project Planning Civil Works § 644.7 Acquisition lines. (a) Tentative acquisition lines. As... submission may be for an entire project or by segments or units. However, if the final map is submitted on...

  15. 2 CFR 200.2 - Acquisition cost.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Acquisition cost. 200.2 Section 200.2 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT... REQUIREMENTS FOR FEDERAL AWARDS Acronyms and Definitions Acronyms § 200.2 Acquisition cost. Acquisition...

  16. Studies in Filipino Second Language Acquisition.

    ERIC Educational Resources Information Center

    Ramos, Teresita V.

    Very little research has been done on first or second language acquisition in the Philippines. Most second language learning studies cited in the literature concern acquisition of English in English-speaking communities, and most American studies of Filipino language acquisition are superficial, consisting primarily of morpheme analysis. The…

  17. 75 FR 19827 - Acquisition Regulation Rewrite

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-15

    ... Acquisition Managers' Partnership (AMP) is a forum for DOI's senior acquisition management community to work... Acquisition and Property Management, Office of the Secretary, telephone (202) 513-0747, fax (202) 219-4244, or... the Office of Management and Budget under Executive Order 12866. (1) This rule will not have an...

  18. Undergraduate Laboratory Data Acquisition With a Microcomputer.

    ERIC Educational Resources Information Center

    Weston, Kenneth C.

    1981-01-01

    Describes a flexible, multichannel, highly accurate, digital data acquisition system for use with a microcomputer. Includes a description of instrumentation for computer data acquisition, data acquisition systems, software, uses in the curriculum, library interaction and action, and use in a mechanical engineering laboratory. (DS)

  19. Defense Acquisition Structures and Capabilities Review

    DTIC Science & Technology

    2007-06-01

    requirements, budget, industry, and organizations. See Defense Acquisition Transformation Report to Congress, John Warner National Defense Authorization Act...Shortage of Skills and Talent. 3 Defense Acquisition Transformation Report to Congress, John Warner National Defense Authorization Act, Fiscal Year...Capabilities, Final Report, January 2004. 28 Secretary of Defense, Defense Acquisition Transformation Report to Congress, John War- ner National Defense

  20. Interkinesics and Interprosodics in Second Language Acquisition.

    ERIC Educational Resources Information Center

    Gassin, June

    1992-01-01

    Assumes unified language behavior including verbal, kinesic, and prosodic forms. Proposes that interlanguage theory should be expanded to include kinesic and prosodic modes of behavior. Suggests that acquisition of second-language kinesic and prosodic forms takes place similarly to acquisition of verbal forms and that acquisition is developmental,…

  1. Pidginization and Creolization as Language Acquisition.

    ERIC Educational Resources Information Center

    Andersen, Roger W., Ed.

    Pidginization and creolization are addressed from a language acquisition perspective. The 18 collected papers are organized around four areas of inquiry: (1) simplification in input to pidginization and second language acquisition, (2) simplification in interlanguage, (3) creolization and language acquisition, and (4) decreolization and language…

  2. Neurobiological Mechanisms of Language Acquisition. Review Article.

    ERIC Educational Resources Information Center

    Pulvermuller, Friedemann; Schumann, John H.

    1994-01-01

    Specifies language acquisition processes in terms of brain mechanisms to explain the variable success achieved by early and late learners and proposes a brain-based model for language acquisition on the basis of the literature. Two conditions for full acquisition of a language are motivation and grammatical ability. The neural underpinnings for…

  3. 14 CFR 151.73 - Land acquisition.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Land acquisition. 151.73 Section 151.73... FEDERAL AID TO AIRPORTS Project Programming Standards § 151.73 Land acquisition. (a) The acquisition of land or any interest therein, or of any easement or other interest in airspace, is eligible...

  4. 14 CFR 151.73 - Land acquisition.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Land acquisition. 151.73 Section 151.73... FEDERAL AID TO AIRPORTS Project Programming Standards § 151.73 Land acquisition. (a) The acquisition of land or any interest therein, or of any easement or other interest in airspace, is eligible...

  5. 14 CFR 151.73 - Land acquisition.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Land acquisition. 151.73 Section 151.73... FEDERAL AID TO AIRPORTS Project Programming Standards § 151.73 Land acquisition. (a) The acquisition of land or any interest therein, or of any easement or other interest in airspace, is eligible...

  6. 14 CFR 151.73 - Land acquisition.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Land acquisition. 151.73 Section 151.73... FEDERAL AID TO AIRPORTS Project Programming Standards § 151.73 Land acquisition. (a) The acquisition of land or any interest therein, or of any easement or other interest in airspace, is eligible...

  7. 14 CFR 151.73 - Land acquisition.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Land acquisition. 151.73 Section 151.73... FEDERAL AID TO AIRPORTS Project Programming Standards § 151.73 Land acquisition. (a) The acquisition of land or any interest therein, or of any easement or other interest in airspace, is eligible...

  8. Photovoltaic module parameters acquisition model

    NASA Astrophysics Data System (ADS)

    Cibira, Gabriel; Koščová, Marcela

    2014-09-01

    This paper presents basic procedures for photovoltaic (PV) module parameters acquisition using MATLAB and Simulink modelling. In first step, MATLAB and Simulink theoretical model are set to calculate I-V and P-V characteristics for PV module based on equivalent electrical circuit. Then, limited I-V data string is obtained from examined PV module using standard measurement equipment at standard irradiation and temperature conditions and stated into MATLAB data matrix as a reference model. Next, the theoretical model is optimized to keep-up with the reference model and to learn its basic parameters relations, over sparse data matrix. Finally, PV module parameters are deliverable for acquisition at different realistic irradiation, temperature conditions as well as series resistance. Besides of output power characteristics and efficiency calculation for PV module or system, proposed model validates computing statistical deviation compared to reference model.

  9. GRAVITY acquisition camera: characterization results

    NASA Astrophysics Data System (ADS)

    Anugu, Narsireddy; Garcia, Paulo; Amorim, Antonio; Wiezorrek, Erich; Wieprecht, Ekkehard; Eisenhauer, Frank; Ott, Thomas; Pfuhl, Oliver; Gordo, Paulo; Perrin, Guy; Brandner, Wolfgang; Straubmeier, Christian; Perraut, Karine

    2016-08-01

    GRAVITY acquisition camera implements four optical functions to track multiple beams of Very Large Telescope Interferometer (VLTI): a) pupil tracker: a 2×2 lenslet images four pupil reference lasers mounted on the spiders of telescope secondary mirror; b) field tracker: images science object; c) pupil imager: reimages telescope pupil; d) aberration tracker: images a Shack-Hartmann. The estimation of beam stabilization parameters from the acquisition camera detector image is carried out, for every 0.7 s, with a dedicated data reduction software. The measured parameters are used in: a) alignment of GRAVITY with the VLTI; b) active pupil and field stabilization; c) defocus correction and engineering purposes. The instrument is now successfully operational on-sky in closed loop. The relevant data reduction and on-sky characterization results are reported.

  10. Music and early language acquisition.

    PubMed

    Brandt, Anthony; Gebrian, Molly; Slevc, L Robert

    2012-01-01

    Language is typically viewed as fundamental to human intelligence. Music, while recognized as a human universal, is often treated as an ancillary ability - one dependent on or derivative of language. In contrast, we argue that it is more productive from a developmental perspective to describe spoken language as a special type of music. A review of existing studies presents a compelling case that musical hearing and ability is essential to language acquisition. In addition, we challenge the prevailing view that music cognition matures more slowly than language and is more difficult; instead, we argue that music learning matches the speed and effort of language acquisition. We conclude that music merits a central place in our understanding of human development.

  11. Centaur propellant acquisition system study

    NASA Technical Reports Server (NTRS)

    Blatt, M. H.; Walter, M. D.

    1975-01-01

    A study was performed to determine the desirability of replacing the hydrogen peroxide settling system on the Centaur D-1S with a capillary acquisition system. A comprehensive screening was performed to select the most promising capillary device fluid acquisition, thermal conditioning, and fabrication techniques. Refillable start baskets and bypass feed start tanks were selected for detailed design. Critical analysis areas were settling and refilling, start sequence development with an initially dry boost pump, and cooling the fluid delivered to the boost pump in order to provide necessary net position suction head (NPSH). Design drawings were prepared for the start basket and start tank concepts for both LO2 and LH2 tanks. System comparisons indicated that the start baskets using wicking for thermal conditioning, and thermal subcooling for boost pump NPSH, are the most desirable systems for future development.

  12. Music and Early Language Acquisition

    PubMed Central

    Brandt, Anthony; Gebrian, Molly; Slevc, L. Robert

    2012-01-01

    Language is typically viewed as fundamental to human intelligence. Music, while recognized as a human universal, is often treated as an ancillary ability – one dependent on or derivative of language. In contrast, we argue that it is more productive from a developmental perspective to describe spoken language as a special type of music. A review of existing studies presents a compelling case that musical hearing and ability is essential to language acquisition. In addition, we challenge the prevailing view that music cognition matures more slowly than language and is more difficult; instead, we argue that music learning matches the speed and effort of language acquisition. We conclude that music merits a central place in our understanding of human development. PMID:22973254

  13. 75 FR 8272 - Defense Federal Acquisition Regulation Supplement; Acquisition Strategies To Ensure Competition...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... Defense Federal Acquisition Regulation Supplement (DFARS) to implement the Weapon Systems Acquisition..., 2009, The Weapon Systems Acquisition Reform Act (Pub. L. 111-23) was enacted to improve the organization and procedures of DoD for the acquisition of major weapon systems. This law establishes...

  14. 75 FR 45072 - Defense Federal Acquisition Regulation Supplement; Inflation Adjustment of Acquisition-Related...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-02

    ...; Inflation Adjustment of Acquisition-Related Thresholds (DFARS Case 2009-D003) AGENCY: Defense Acquisition... the adjustment of acquisition-related thresholds for inflation just maintains the status quo. No... thresholds for inflation: 0704-0229--Defense Federal Acquisition Regulation Supplement Part 225,...

  15. The Cybersecurity Challenge in Acquisition

    DTIC Science & Technology

    2016-04-30

    physicians and medical staff were paralyzed, and they suddenly had to rely on paper records to keep operations running. The hospital chose to pay hackers a...record systems. Since the cyber threats keep changing and evolving, how is a manager trained in acquisition supposed to keep track? Target Levels...U.S. Central Command get plenty of attention . Cyber-attacks involving internal resources (i.e., business partners and direct employees) do not get the

  16. WRATS Integrated Data Acquisition System

    NASA Technical Reports Server (NTRS)

    Piatak, David J.

    2008-01-01

    The Wing and Rotor Aeroelastic Test System (WRATS) data acquisition system (DAS) is a 64-channel data acquisition display and analysis system specifically designed for use with the WRATS 1/5-scale V-22 tiltrotor model of the Bell Osprey. It is the primary data acquisition system for experimental aeroelastic testing of the WRATS model for the purpose of characterizing the aeromechanical and aeroelastic stability of prototype tiltrotor configurations. The WRATS DAS was also used during aeroelastic testing of Bell Helicopter Textron s Quad-Tiltrotor (QTR) design concept, a test which received international attention. The LabVIEW-based design is portable and capable of powering and conditioning over 64 channels of dynamic data at sampling rates up to 1,000 Hz. The system includes a 60-second circular data archive, an integrated model swashplate excitation system, a moving block damping application for calculation of whirl flutter mode subcritical damping, a loads and safety monitor, a pilot-control console display, data analysis capabilities, and instrumentation calibration functions. Three networked computers running custom-designed LabVIEW software acquire data through National Instruments data acquisition hardware. The aeroelastic model (see figure) was tested with the DAS at two facilities at NASA Langley, the Transonic Dynamics Tunnel (TDT) and the Rotorcraft Hover Test Facility (RHTF). Because of the need for seamless transition between testing at these facilities, DAS is portable. The software is capable of harmonic analysis of periodic time history data, Fast Fourier Transform calculations, power spectral density calculations, and on-line calibration of test instrumentation. DAS has a circular buffer archive to ensure critical data is not lost in event of model failure/incident, as well as a sample-and-hold capability for phase-correct time history data.

  17. Enhanced Data-Acquisition System

    NASA Technical Reports Server (NTRS)

    Mustain, Roy W.

    1990-01-01

    Time-consuming, costly digitization of analog signals on magnetic tape eliminated. Proposed data-acquisition system provides nearly immediate access to data in incoming signals by digitizing and recording them both on magnetic tape and on optical disk. Tape and/or disk later played back to reconstruct signals in analog or digital form for analysis. Of interest in industrial and scientific applications in which necessary to digitize, store, and/or process large quantities of experimental data.

  18. Peruvian Weapon System Acquisition Process

    DTIC Science & Technology

    1990-12-01

    process for a major program. The United States DOD Directive 5000.1 defines four distinct phases of the acquisition process: concept exploration , demon...Unified or Specified Command. 1. Concept Exploration Phase The first phase for a major system is the concept exploration phase. During this phase... exploration phase proreses. Premature introduction of operating and support details may have a negative effect by dosing out promising alternatives [Ref

  19. Data Acquisition and Mass Storage

    NASA Astrophysics Data System (ADS)

    Vande Vyvre, P.

    2004-08-01

    The experiments performed at supercolliders will constitute a new challenge in several disciplines of High Energy Physics and Information Technology. This will definitely be the case for data acquisition and mass storage. The microelectronics, communication, and computing industries are maintaining an exponential increase of the performance of their products. The market of commodity products remains the largest and the most competitive market of technology products. This constitutes a strong incentive to use these commodity products extensively as components to build the data acquisition and computing infrastructures of the future generation of experiments. The present generation of experiments in Europe and in the US already constitutes an important step in this direction. The experience acquired in the design and the construction of the present experiments has to be complemented by a large R&D effort executed with good awareness of industry developments. The future experiments will also be expected to follow major trends of our present world: deliver physics results faster and become more and more visible and accessible. The present evolution of the technologies and the burgeoning of GRID projects indicate that these trends will be made possible. This paper includes a brief overview of the technologies currently used for the different tasks of the experimental data chain: data acquisition, selection, storage, processing, and analysis. The major trends of the computing and networking technologies are then indicated with particular attention paid to their influence on the future experiments. Finally, the vision of future data acquisition and processing systems and their promise for future supercolliders is presented.

  20. Aerial robotic data acquisition system

    SciTech Connect

    Hofstetter, K.J.; Hayes, D.W.; Pendergast, M.M.; Corban, J.E.

    1993-12-31

    A small, unmanned aerial vehicle (UAV), equipped with sensors for physical and chemical measurements of remote environments, is described. A miniature helicopter airframe is used as a platform for sensor testing and development. The sensor output is integrated with the flight control system for real-time, interactive, data acquisition and analysis. Pre-programmed flight missions will be flown with several sensors to demonstrate the cost-effective surveillance capabilities of this new technology.

  1. Affordability of Defense Acquisition Programs

    DTIC Science & Technology

    2015-02-01

    the Office of Director, Cost Assessment and Program Evaluation (CAPE). The DPP is a particularly useful tool for assessing the affordability of DOD...within the Service programming communities. • The Defense Program Projection is a valuable tool for DOD’s use in assessing affordability; however, in... tool for assessing the affordability of future acquisition in the spirit of the Better Buying Power initiative. A. Ground Rules, Assumptions, and

  2. Acquisition, Image and Data Compression.

    DTIC Science & Technology

    1983-04-30

    In Block 20, If different from Report) 1. SUPPLEMENTARY NOTES Presentations made at MILCOM󈨖 Optical Society 󈨗 SPIE󈨗 Optical Computing...Conference󈨗. 19. KEY WORDS (Continue on reverse aide It necessary end identify by block number) Spread Spectrum, Optical Transforms, Acquisition, Simulation...Tracking, PN Direct Sequence Frequency Hopping 20. ABSTRACT (Continue on reer. aide it nece-iary end Identify hy block nomber) This report discusses

  3. Jefferson Lab's Distributed Data Acquisition

    SciTech Connect

    Trent Allison; Thomas Powers

    2006-05-01

    Jefferson Lab's Continuous Electron Beam Accelerator Facility (CEBAF) occasionally experiences fast intermittent beam instabilities that are difficult to isolate and result in downtime. The Distributed Data Acquisition (Dist DAQ) system is being developed to detect and quickly locate such instabilities. It will consist of multiple Ethernet based data acquisition chassis distributed throughout the seven-eights of a mile CEBAF site. Each chassis will monitor various control system signals that are only available locally and/or monitored by systems with small bandwidths that cannot identify fast transients. The chassis will collect data at rates up to 40 Msps in circular buffers that can be frozen and unrolled after an event trigger. These triggers will be derived from signals such as periodic timers or accelerator faults and be distributed via a custom fiber optic event trigger network. This triggering scheme will allow all the data acquisition chassis to be triggered simultaneously and provide a snapshot of relevant CEBAF control signals. The data will then be automatically analyzed for frequency content and transients to determine if and where instabilities exist.

  4. Confidence-Based Feature Acquisition

    NASA Technical Reports Server (NTRS)

    Wagstaff, Kiri L.; desJardins, Marie; MacGlashan, James

    2010-01-01

    Confidence-based Feature Acquisition (CFA) is a novel, supervised learning method for acquiring missing feature values when there is missing data at both training (learning) and test (deployment) time. To train a machine learning classifier, data is encoded with a series of input features describing each item. In some applications, the training data may have missing values for some of the features, which can be acquired at a given cost. A relevant JPL example is that of the Mars rover exploration in which the features are obtained from a variety of different instruments, with different power consumption and integration time costs. The challenge is to decide which features will lead to increased classification performance and are therefore worth acquiring (paying the cost). To solve this problem, CFA, which is made up of two algorithms (CFA-train and CFA-predict), has been designed to greedily minimize total acquisition cost (during training and testing) while aiming for a specific accuracy level (specified as a confidence threshold). With this method, it is assumed that there is a nonempty subset of features that are free; that is, every instance in the data set includes these features initially for zero cost. It is also assumed that the feature acquisition (FA) cost associated with each feature is known in advance, and that the FA cost for a given feature is the same for all instances. Finally, CFA requires that the base-level classifiers produce not only a classification, but also a confidence (or posterior probability).

  5. The Telecommunications and Data Acquisition

    NASA Technical Reports Server (NTRS)

    Posner, Edward C. (Editor)

    1992-01-01

    This quarterly publication provides archival reports on developments in programs managed by JPL's Office of Telecommunications and Data Acquisition (TDA). In space communications, radio navigation, radio science, and ground-based radio and radar astronomy, it reports on activities of the Deep Space Network (DSN) in planning, supporting research and technology, implementation, and operations. Also included are standards activity at JPL for space data and information systems and reimbursable DSN work performed for other space agencies through NASA. The preceding work is all performed for NASA's Office of Space Communications (OSC).

  6. System Safety in Aircraft Acquisition

    DTIC Science & Technology

    1984-01-01

    principal purpose is the prevention of accidents or deaths/ injuries related thereto. Until a recent meeting cosponsored by SOHP and OUSDRE, communication...results in preventing the loss of a single aircraft ML.214/9OV 83 ($15 million for the AH-64, $25 million for the F-18, $200 million for the B-1B). - An...acquisition program. There- fore, it is essential to have interest and support of system safety by "off-line" management at levels high enough to be effective

  7. DSP based data acquisition system

    NASA Astrophysics Data System (ADS)

    Prasad, Peeyush; Subrahmanya, C. R.

    A new DSP based data acquisition system based on commercial, off-the-shelf available hardware is presented. The board features friendly high speed input and output interfaces, a powerful DSP and hardware offloading of essing to an FPGA. For flexibility of development, a soft realtime linux based kernel popular among embedded developers (uClinux) has been ported on the board.The development environment is fully open source both for the target as well as for host software. The motivation behind creating the system, the development ess and the current status is described. Some results obtained with this system as used in typical applications are also presented.

  8. DEAP-3600 Data Acquisition System

    NASA Astrophysics Data System (ADS)

    Lindner, Thomas

    2015-12-01

    DEAP-3600 is a dark matter experiment using liquid argon to detect Weakly Interacting Massive Particles (WIMPs). The DEAP-3600 Data Acquisition (DAQ) has been built using a combination of commercial and custom electronics, organized using the MIDAS framework. The DAQ system needs to suppress a high rate of background events from 39Ar beta decays. This suppression is implemented using a combination of online firmware and software-based event filtering. We will report on progress commissioning the DAQ system, as well as the development of the web-based user interface.

  9. Inflation Adjustments for Defense Acquisition

    DTIC Science & Technology

    2014-10-01

    Harmon Daniel B. Levine Stanley A. Horowitz, Project Leader INSTITUTE FOR DEFENSE ANALYSES 4850 Mark Center Drive Alexandria, Virginia 22311-1882 Approved...T U T E F O R D E F E N S E A N A L Y S E S IDA Document D-5112 Inflation Adjustments for Defense Acquisition Bruce R. Harmon Daniel B. Levine...might do a better job? The focus of the study is on aircraft procurement. By way of terminology , “cost index,” “price index,” and “deflator” are used

  10. Sample acquisition and instrument deployment

    NASA Technical Reports Server (NTRS)

    Boyd, Robert C.

    1995-01-01

    Progress is reported in developing the Sample Acquisition and Instrument Deployment (SAID) system, a robotic system for deploying science instruments and acquiring samples for analysis. The system is a conventional four degree of freedom manipulator 2 meters in length. A baseline design has been achieved through analysis and trade studies. The design considers environmental operating conditions on the surface of Mars, as well as volume constraints on proposed Mars landers. Control issues have also been studied, and simulations of joint and tip movements have been performed. The systems have been fabricated and tested in environmental chambers, as well as soil testing and robotic control testing.

  11. On acquisition of programming knowledge

    NASA Technical Reports Server (NTRS)

    Amin, Ashok T.

    1987-01-01

    For the evolving discipline of programming, acquisition of programming knowledge is a difficult issue. Common knowledge results from the acceptance of proven techniques based on results of formal inquiries into the nature of the programming process. This is a rather slow process. In addition, the vast body of common knowledge needs to be explicated to a low enough level of details for it to be represented in the machine processable form. It is felt that this is an impediment to the progress of automatic programming. The importance of formal approaches cannot be overstated since their contributions lead to quantum leaps in the state of the art.

  12. Subsea control and data acquisition

    SciTech Connect

    Not Available

    1990-01-01

    This book contains papers presented at the conference on subsea control and data acquisition. The tasks performed by subsea control systems, although fairly straightforward, are dominated by an alien environment and the high costs associated with failure and repair. The evolution of systems design has resulted in a growing confidence in equipment reliability. In the future, however, more searching demands may include active regulation of valves and the use of data for reservoir management purposes. The emphasis of the papers is on technical depth and understanding, with particular attention being paid to the science control and data monitoring in relation to the task of hydrocarbon recovery.

  13. Symbiont acquisition as neoseme: origin of species and higher taxa

    NASA Technical Reports Server (NTRS)

    Bermudes, D.; Margulis, L.

    1987-01-01

    We examine the hypothesis that, in the origin of species and higher taxa of eukaryotes, symbiont acquisition followed by partner integration has been equivalent to neoseme appearance leading to speciation. The formation of stable symbiotic associations involves partner-surface recognition, behavioral and metabolic interaction, and, in some cases, gene product (RNA, protein) and genic (RNA, DNA) integration. This analysis is applied here to examples of neosemes that define specific taxa and to neosemes in plants, fungi, and animals that involve the appearance of new types of tissue. If this hypothesis is correct--if the origin of major genetic variation leading to speciation and even higher taxa may occur through symbiont acquisition and integration--then the analysis of "origins of species and higher taxa" becomes analogous to the study of microbial community ecology.

  14. Acquisition of English comparative adjectives.

    PubMed

    Graziano-King, Janine; Cairns, Helen Smith

    2005-05-01

    Two experiments investigated the acquisition of English comparative adjective forms, Adj + er and more Adj. In Experiment 1, 72 children, four- and seven-years-old, indicated their preferences for the synthetic or periphrastic comparative form for 16 adjectives in a forced-choice judgement task; their responses were compared to those of a group of adults (Graziano-King, 2003). In Experiment 2, a group of 29 children, ranging in age from 5;1 to 10;9, and a group of 11 adults performed a forced-choice judgement task, similar to that of Experiment 1, and an elicited production task, responding to the same 32 adjectives for both tasks. The two studies together support an acquisition trajectory of three stages. In the first stage, children show no preference for either form of the comparative; in the second, they adopt a suffixation rule; and in the third, they abandon the general rule and become conservative learners, eventually reaching the adult target.

  15. The NIFFTE Data Acquisition System

    NASA Astrophysics Data System (ADS)

    Qu, Hai; Niffte Collaboration

    2011-10-01

    The Neutron Induced Fission Fragment Tracking Experiment (NIFFTE) will employ a novel, high granularity, pressurized Time Projection Chamber to measure fission cross-sections of the major actinides to high precision over a wide incident neutron energy range. These results will improve nuclear data accuracy and benefit the fuel cycle in the future. The NIFFTE data acquisition system (DAQ) has been designed and implemented on the prototype TPC. Lessons learned from engineering runs have been incorporated into some design changes that are being implemented before the next run cycle. A fully instrumented sextant of EtherDAQ cards (16 sectors, 496 channels) will be used for the next run cycle. The Maximum Integrated Data Acquisition System (MIDAS) has been chosen and customized to configure and run the experiment. It also meets the requirement for remote control and monitoring of the system. The integration of the MIDAS online database with the persistent PostgreSQL database has been implemented for experiment usage. The detailed design and current status of the DAQ system will be presented.

  16. Rotary Percussive Sample Acquisition Tool

    NASA Technical Reports Server (NTRS)

    Klein, K.; Badescu, M.; Haddad, N.; Shiraishi, L.; Walkemeyer, P.

    2012-01-01

    As part of a potential Mars Sample Return campaign NASA is studying a sample caching mission to Mars, with a possible 2018 launch opportunity. As such, a Sample Acquisition Tool (SAT) has been developed in support of the Integrated Mars Sample Acquisition and Handling (IMSAH) architecture as it relates to the proposed Mars Sample Return (MSR) campaign. The tool allows for core generation and capture directly into a sample tube. In doing so, the sample tube becomes the fundamental handling element within the IMSAH sample chain reducing the risk associated with sample contamination as well as the need to handle a sample of unknown geometry. The tool's functionality was verified utilizing a proposed rock test suite that encompasses a series of rock types that have been utilized in the past to qualify Martian surface sampling hardware. The corresponding results have shown the tool can effectively generate, fracture, and capture rock cores while maintaining torque margins of no less than 50% with an average power consumption of no greater than 90W and a tool mass of less than 6kg.

  17. Acquisition Pros Keep the Gears Moving

    DTIC Science & Technology

    2015-06-01

    Defense AT&L: May–June 2015 42 Acquisition Pros Keep the Gears Moving Janice Laurenti Laurenti is a contract specialist at the Air Force Training ...The deci- sion to downsize later was found to have failed to increase efficiency. But there is light at the end of the tunnel. Today’s up -and...includes identifying additional DoD-wide areas of training for the acquisition workforce. Three Critical Components Acquisitions are as diverse

  18. Learning the manifold of quality ultrasound acquisition.

    PubMed

    El-Zehiry, Noha; Yan, Michelle; Good, Sara; Fang, Tong; Zhou, S Kevin; Grady, Leo

    2013-01-01

    Ultrasound acquisition is a challenging task that requires simultaneous adjustment of several acquisition parameters (the depth, the focus, the frequency and its operation mode). If the acquisition parameters are not properly chosen, the resulting image will have a poor quality and will degrade the patient diagnosis and treatment workflow. Several hardware-based systems for autotuning the acquisition parameters have been previously proposed, but these solutions were largely abandoned because they failed to properly account for tissue inhomogeneity and other patient-specific characteristics. Consequently, in routine practice the clinician either uses population-based parameter presets or manually adjusts the acquisition parameters for each patient during the scan. In this paper, we revisit the problem of autotuning the acquisition parameters by taking a completely novel approach and producing a solution based on image analytics. Our solution is inspired by the autofocus capability of conventional digital cameras, but is significantly more challenging because the number of acquisition parameters is large and the determination of "good quality" images is more difficult to assess. Surprisingly, we show that the set of acquisition parameters which produce images that are favored by clinicians comprise a 1D manifold, allowing for a real-time optimization to maximize image quality. We demonstrate our method for acquisition parameter autotuning on several live patients, showing that our system can start with a poor initial set of parameters and automatically optimize the parameters to produce high quality images.

  19. 78 FR 70482 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-71; Small Entity Compliance Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-25

    ... GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 48 CFR Chapter 1 Federal Acquisition Regulation; Federal Acquisition Circular 2005-71; Small Entity Compliance Guide AGENCY: Department of Defense (DoD), General Services Administration (GSA), and National Aeronautics and...

  20. 77 FR 13951 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-57; Introduction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-07

    ...; Introduction; United States-Korea Free Trade Agreement; Small Entity Compliance Guide; Final Rules #0;#0... Chapter 1 Federal Acquisition Regulation; Federal Acquisition Circular 2005-57; Introduction...

  1. Passive acquisition of CLIPS rules

    NASA Technical Reports Server (NTRS)

    Kovarik, Vincent J., Jr.

    1991-01-01

    The automated acquisition of knowledge by machine has not lived up to expectations, and knowledge engineering remains a human intensive task. Part of the reason for the lack of success is the difference in the cognitive focus of the expert. The expert must shift his or her focus from the subject domain to that of the representation environment. In doing so this cognitive shift introduces opportunity for errors and omissions. Presented here is work that observes the expert interact with a simulation of the domain. The system logs changes in the simulation objects and the expert's actions in response to those changes. This is followed by the application of inductive reasoning to move the domain specific rules observed to general domain rules.

  2. Surface acquisition through virtual milling

    NASA Technical Reports Server (NTRS)

    Merriam, Marshal L.

    1993-01-01

    Surface acquisition deals with the reconstruction of three dimensional objects from a set of data points. The most straightforward techniques require human intervention, a time consuming proposition. It is desirable to develop a fully automated alternative. Such a method is proposed in this paper. It makes use of surface measurements obtained from a 3-D laser digitizer - an instrument which provides the (x,y,z) coordinates of surface data points from various viewpoints. These points are assembled into several partial surfaces using a visibility constraint and a 2-D triangulation technique. Reconstruction of the final object requires merging these partial surfaces. This is accomplished through a procedure that emulates milling, a standard machining operation. From a geometrical standpoint the problem reduces to constructing the intersection of two or more non-convex polyhedra.

  3. Digital data acquisition and processing.

    PubMed

    Naivar, Mark A; Galbraith, David W

    2015-01-05

    A flow cytometer is made up of many different subsystems that work together to measure the optical properties of individual cells within a sample. The data acquisition system (also called the data system) is one of these subsystems, and it is responsible for converting the electrical signals from the optical detectors into list-mode data. This unit describes the inner workings of the data system, and provides insight into how the instrument functions as a whole. Some of the information provided in this unit is applicable to everyday use of these instruments, and, at minimum, should make it easier for the reader to assemble a specific data system. With the considerable advancement of electronics technology, it becomes possible to build an entirely functional data system using inexpensive hobbyist-level electronics. This unit covers both analog and digital data systems, but the primary focus is on the more prevalent digital data systems of modern flow cytometric instrumentation.

  4. Language acquisition is language change.

    PubMed

    Crain, Stephen; Goro, Takuya; Thornton, Rosalind

    2006-01-01

    According to the theory of Universal Grammar, the primary linguistic data guides children through an innately specified space of hypotheses. On this view, similarities between child-English and adult-German are as unsurprising as similarities between cousins who have never met. By contrast, experience-based approaches to language acquisition contend that child language matches the input, with nonadult forms being simply less articulated versions of the forms produced by adults. This paper reports several studies that provide support for the theory of Universal grammar, and resist explanation on experience-based accounts. Two studies investigate English-speaking children's productions, and a third examines the interpretation of sentences by Japanese speaking children. When considered against the input children are exposed to, the findings of these and other studies are consistent with the continuity hypothesis, which supposes that child language can differ from the language spoken by adults only in ways that adult languages can differ from each other.

  5. Expressing fear enhances sensory acquisition.

    PubMed

    Susskind, Joshua M; Lee, Daniel H; Cusi, Andrée; Feiman, Roman; Grabski, Wojtek; Anderson, Adam K

    2008-07-01

    It has been proposed that facial expression production originates in sensory regulation. Here we demonstrate that facial expressions of fear are configured to enhance sensory acquisition. A statistical model of expression appearance revealed that fear and disgust expressions have opposite shape and surface reflectance features. We hypothesized that this reflects a fundamental antagonism serving to augment versus diminish sensory exposure. In keeping with this hypothesis, when subjects posed expressions of fear, they had a subjectively larger visual field, faster eye movements during target localization and an increase in nasal volume and air velocity during inspiration. The opposite pattern was found for disgust. Fear may therefore work to enhance perception, whereas disgust dampens it. These convergent results provide support for the Darwinian hypothesis that facial expressions are not arbitrary configurations for social communication, but rather, expressions may have originated in altering the sensory interface with the physical world.

  6. Optimality theory in phonological acquisition.

    PubMed

    Barlow, J A; Gierut, J A

    1999-12-01

    This tutorial presents an introduction to the contemporary linguistic framework known as optimality theory (OT). The basic assumptions of this constraint-based theory as a general model of grammar are first outlined, with formal notation being defined and illustrated. Concepts unique to the theory, including "emergence of the unmarked," are also described. OT is then examined more specifically within the context of phonological acquisition. The theory is applied in descriptions of children's common error patterns, observed inter- and intrachild variation, and productive change over time. The particular error patterns of fronting, stopping, final-consonant deletion, and cluster simplification are considered from an OT perspective. The discussion concludes with potential clinical applications and extensions of the theory to the diagnosis and treatment of children with functional phonological disorders.

  7. 78 FR 73472 - Defense Federal Acquisition Regulation Supplement: Application of Certain Clauses to Acquisitions...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-06

    ... Acquisition Regulation Supplement: Application of Certain Clauses to Acquisitions of Commercial Items (DFARS... (DFARS) to clarify the applicability of two clauses to acquisitions of commercial items. DATES: Comment... of commercial items by adding them to the list at 212.301(f) and revising the clause prescriptions...

  8. Enseignement des langues et theories d'acquisition Sprachunterricht unde Spracherwerbstheorien. (Language Teaching and Acquisition Theories).

    ERIC Educational Resources Information Center

    Schwarz, Alexander, Ed.

    1996-01-01

    This collection of articles on language teaching and language acquisition theories includes: "Enseignement des langues et theories de l'acquisition. Introduction au colloque" ("Language Teaching and Theories of Acquisition. Introduction to the Colloquium") (Rene Richterich); "Apprendre une langue dans l'interaction verbale" ("Language Learning in…

  9. 75 FR 54524 - Defense Federal Acquisition Regulation Supplement; Acquisition Strategies To Ensure Competition...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-08

    ... Weapon Systems Acquisition Reform Act of 2009, to improve the organization and procedures of DoD for the acquisition of major weapon systems. DATES: Effective Date: September 8, 2010. FOR FURTHER INFORMATION CONTACT... Weapon Systems Acquisition Reform Act (Pub. L. 111-23) was enacted to improve the organization...

  10. 75 FR 3187 - Defense Federal Acquisition Regulation Supplement: Inflation Adjustment of Acquisition-Related...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ... adjustment every 5 years of statutory acquisition- related thresholds, except for Davis-Bacon Act, Service... acquisition-related thresholds, except for Davis-Bacon Act, Service Contract Act, and trade agreements... acquisition-related thresholds established by the Davis Bacon Act, the Service Contract Act, or...

  11. The Status of Functional Categories in Child Second Language Acquisition: Evidence from the Acquisition of CP.

    ERIC Educational Resources Information Center

    Haznedar, Belma

    2003-01-01

    Examines the status of the functional categories in child second language (L2) acquisition of English. Results from longitudinally-collected data are reported, presenting counterevidence for recent hypotheses on early L2 acquisition that assume the following: (1) structure building approach according to which the acquisition of functional…

  12. Iron acquisition in the cystic fibrosis lung and potential for novel therapeutic strategies

    PubMed Central

    Tyrrell, Jean

    2016-01-01

    Iron acquisition is vital to microbial survival and is implicated in the virulence of many of the pathogens that reside in the cystic fibrosis (CF) lung. The multifaceted nature of iron acquisition by both bacterial and fungal pathogens encompasses a range of conserved and species-specific mechanisms, including secretion of iron-binding siderophores, utilization of siderophores from other species, release of iron from host iron-binding proteins and haemoproteins, and ferrous iron uptake. Pathogens adapt and deploy specific systems depending on iron availability, bioavailability of the iron pool, stage of infection and presence of competing pathogens. Understanding the dynamics of pathogen iron acquisition has the potential to unveil new avenues for therapeutic intervention to treat both acute and chronic CF infections. Here, we examine the range of strategies utilized by the primary CF pathogens to acquire iron and discuss the different approaches to targeting iron acquisition systems as an antimicrobial strategy. PMID:26643057

  13. Webpage Segments Classification with Incremental Knowledge Acquisition

    NASA Astrophysics Data System (ADS)

    Guo, Wei; Kim, Yang Sok; Kang, Byeong Ho

    This paper suggests an incremental information extraction method for social network analysis of web publications. For this purpose, we employed an incremental knowledge acquisition method, called MCRDR (Multiple Classification Ripple-Down Rules), to classify web page segments. Our experimental results show that our MCRDR-based web page segments classification system successfully supports easy acquisition and maintenance of information extraction rules.

  14. 48 CFR 970.2301 - Sustainable acquisition.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    .... 970.2301 Section 970.2301 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Environment, Energy and Water Efficiency, Renewable Energy Technologies, Occupational Safety and Drug-Free Work Place 970.2301 Sustainable acquisition....

  15. Input and Intake in Language Acquisition

    ERIC Educational Resources Information Center

    Gagliardi, Ann C.

    2012-01-01

    This dissertation presents an approach for a productive way forward in the study of language acquisition, sealing the rift between claims of an innate linguistic hypothesis space and powerful domain general statistical inference. This approach breaks language acquisition into its component parts, distinguishing the input in the environment from…

  16. Managing Requirements for Acquisition Program Affordability

    DTIC Science & Technology

    2012-04-14

    to buy weapon systems at a lower cost and higher quality by leveraging commercial technology. He also directed program managers (PMs) and... Managing Requirements for Acquisition Program Affordability by Colonel James O. Winbush, Jr. United States Army...2011 to 11-04-2012 4. TITLE AND SUBTITLE Managing Requirements for Acquisition Program Affordability 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c

  17. 16 CFR 801.4 - Secondary acquisitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Secondary acquisitions. 801.4 Section 801.4 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 COVERAGE RULES § 801.4 Secondary acquisitions....

  18. 16 CFR 801.4 - Secondary acquisitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Secondary acquisitions. 801.4 Section 801.4 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 COVERAGE RULES § 801.4 Secondary acquisitions....

  19. 16 CFR 801.4 - Secondary acquisitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Secondary acquisitions. 801.4 Section 801.4 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 COVERAGE RULES § 801.4 Secondary acquisitions....

  20. 16 CFR 801.4 - Secondary acquisitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Secondary acquisitions. 801.4 Section 801.4 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 COVERAGE RULES § 801.4 Secondary acquisitions....

  1. 16 CFR 801.4 - Secondary acquisitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Secondary acquisitions. 801.4 Section 801.4 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 COVERAGE RULES § 801.4 Secondary acquisitions....

  2. Second Language Acquisition: Research and Applied Linguistics.

    ERIC Educational Resources Information Center

    Pica, Teresa

    2003-01-01

    This paper provides an overview of second language acquisition (SLA) research over the past several decades and highlights the ways in which it has retained its original applied and linguistic interests and enhanced them by addressing questions about acquisition processes. After discussing disciplinary contexts (SLA research and applied…

  3. How Long Does Intonation Acquisition Take?

    ERIC Educational Resources Information Center

    Cruttenden, Alan

    The evidence on the acquisition of intonation by children is reviewed. Reports on the early use of pitch contours fall into two categories, imitational and differential intonation. While imitational intonation is based on mimicry of adults, differential intonation involves the acquisition of two or three tunes that contrast in meaning from an…

  4. Defense Acquisition University Program Managers Tool Kit

    DTIC Science & Technology

    2011-01-01

    International Standards Organization ( ISO ) registration of a supplier’s quality system since there have been instances where ISO 9001 -registered supplier...58 Quality Management Systems (Defense Acquisition Guidebook...facilities and equipment. DAU PROGRAM MANAGERS TOOL KIT 59 Quality Management Systems (see Defense Acquisition Guidebook) • The PM should allow

  5. The Acquisition of English Pronunciation: Learners' Views.

    ERIC Educational Resources Information Center

    Cenoz, Jasone; Lecumberri, Ma Luisa Garcia

    1999-01-01

    Describes English learners' views on the acquisition of the phonetic component of English by focusing on (1) their awareness of the difficulty and importance of English pronunciation, and (2) their beliefs about influential factors in the acquisition of pronunciation and their attitudes towards English accents. Examines differences in phonetic…

  6. Programmatic Ahistoricity in Second Language Acquisition Theory.

    ERIC Educational Resources Information Center

    Thomas, Margaret

    1998-01-01

    Suggests that, despite some perceptions, second language acquisition theory has a history. Disputes arguments that might be formulated to support the notion that second language acquisition theory has no relevant earlier history, enumerates consequences of maintaining this belief, and speculates about benefits to the field that might accrue from…

  7. 77 FR 59339 - Acquisition of Commercial Items

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-27

    ... [Federal Register Volume 77, Number 188 (Thursday, September 27, 2012)] [Rules and Regulations] [Page 59339] [FR Doc No: 2012-23917] DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 212 Acquisition of Commercial Items CFR Correction 212.504 [Corrected] In Title 48 of the Code...

  8. Preliminary Study of Child's Second Language Acquisition.

    ERIC Educational Resources Information Center

    Yumoto, Kazuko

    1984-01-01

    A naturalistic study looked at the acquisition of English by two Japanese boys, aged 4 and 8 years, during a 2.5-year stay in the United States. Data were collected through observation and transcription of spontaneous speech in daily life. Analysis included a variety of features of language use and of the acquisition process, including attitudes…

  9. Multilingual Language Acquisition in Canada and Germany.

    ERIC Educational Resources Information Center

    Hufeisen, Britta

    1995-01-01

    Examines multilingual settings in Canada and Germany and explores the differentiation between second- and third-language acquisition as well as the differentiation between acquisition and learning. The article outlines priority areas for further research and presents the prospects for a greater recognition of multilingualism as a resource in…

  10. Acquisition Initiatives Review-Phase 2

    DTIC Science & Technology

    2006-02-01

    Actions to Strengthen the TRA Process................................. II-9 III. Improving Acountability in the Acquisition Workforce A. Clear Command...BETTER ACOUNTABILITY IN THE ACQUISITION WORKFORCE In its simplest terms, the Packard Commission recommended that DoD implement an industry model with...evaluation staff. II-10 This page is intentionally left blank. III-1 III. IMPROVING ACOUNTABILITY IN THE

  11. 75 FR 10567 - Commerce Acquisition Regulation (CAR)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-08

    ...We, the Department of Commerce, issue a final rule to bring the Commerce Acquisition Regulation in alignment with the Federal Acquisition Regulation (FAR) and to streamline DOC's internal policy and guidance. This final rule updates the entire CAR through FAC 2005-...

  12. EBT data acquisition and analysis system

    SciTech Connect

    Burris, R.D.; Greenwood, D.E.; Stanton, J.S.; Geoffroy, K.A.

    1980-10-01

    This document describes the design and implementation of a data acquisition and analysis system for the EBT fusion experiment. The system includes data acquisition on five computers, automatic transmission of that data to a large, central data base, and a powerful data retrieval system. The system is flexible and easy to use, and it provides a fully documented record of the experiments.

  13. 78 FR 35195 - Acquisition Regulations: Export Control

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-12

    ... Parts 925, 952, and 970 RIN 1991-AB99 Acquisition Regulations: Export Control AGENCY: Department of... amend the Department of Energy Acquisition Regulation (DEAR) to add export control requirements... ``DEAR: Export Control and RIN 1991-AB99,'' by any of the following methods: Federal eRulemaking...

  14. 78 FR 45168 - Acquisition Regulations: Export Control

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-26

    ... Parts 925, 952 and 970 RIN 1991-AB99 Acquisition Regulations: Export Control AGENCY: Department of... Department of Energy Acquisition Regulation (DEAR) to add export control requirements applicable to the... business August 23, 2013. ADDRESSES: You may submit comments, identified by ``DEAR: Export Control and...

  15. 48 CFR 970.2301 - Sustainable acquisition.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    .... 970.2301 Section 970.2301 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Environment, Energy and Water Efficiency, Renewable Energy Technologies, Occupational Safety and Drug-Free Work Place 970.2301 Sustainable acquisition....

  16. 48 CFR 970.2301 - Sustainable acquisition.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    .... 970.2301 Section 970.2301 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Environment, Energy and Water Efficiency, Renewable Energy Technologies, Occupational Safety and Drug-Free Work Place 970.2301 Sustainable acquisition....

  17. 48 CFR 970.2301 - Sustainable acquisition.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .... 970.2301 Section 970.2301 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Environment, Energy and Water Efficiency, Renewable Energy Technologies, Occupational Safety and Drug-Free Work Place 970.2301 Sustainable acquisition....

  18. You Can Accurately Predict Land Acquisition Costs.

    ERIC Educational Resources Information Center

    Garrigan, Richard

    1967-01-01

    Land acquisition costs were tested for predictability based upon the 1962 assessed valuations of privately held land acquired for campus expansion by the University of Wisconsin from 1963-1965. By correlating the land acquisition costs of 108 properties acquired during the 3 year period with--(1) the assessed value of the land, (2) the assessed…

  19. 40 CFR 35.2210 - Land acquisition.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Land acquisition. 35.2210 Section 35.2210 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works § 35.2210 Land acquisition....

  20. 40 CFR 35.2210 - Land acquisition.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Land acquisition. 35.2210 Section 35.2210 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works § 35.2210 Land acquisition....

  1. 40 CFR 35.2210 - Land acquisition.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Land acquisition. 35.2210 Section 35.2210 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works § 35.2210 Land acquisition....

  2. 40 CFR 35.2210 - Land acquisition.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Land acquisition. 35.2210 Section 35.2210 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works § 35.2210 Land acquisition....

  3. 40 CFR 35.2210 - Land acquisition.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Land acquisition. 35.2210 Section 35.2210 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works § 35.2210 Land acquisition....

  4. Kuwaiti Arabic: Acquisition of Singleton Consonants

    ERIC Educational Resources Information Center

    Ayyad, Hadeel Salama; Bernhardt, B. May; Stemberger, Joseph P.

    2016-01-01

    Background: Arabic, a Semitic language of the Afro-Asiatic variety, has a rich consonant inventory. Previous studies on Arabic phonological acquisition have focused primarily on dialects in Jordan and Egypt. Because Arabic varies considerably across regions, information is also needed for other dialects. Aims: To determine acquisition benchmarks…

  5. Risk Management Programs for Defense Acquisition Systems

    DTIC Science & Technology

    2007-11-02

    The audit objective was to evaluate the effectiveness of risk management programs for Defense acquisition systems. Specifically, we determined whether DoD risk management policies and procedures for Defense acquisition systems were effectively implemented and what impact risk management programs bad on reducing program risks and costs. We also reviewed management controls as they applied to the audit objectives.

  6. Child Language Acquisition: Contrasting Theoretical Approaches

    ERIC Educational Resources Information Center

    Ambridge, Ben; Lieven, Elena V. M.

    2011-01-01

    Is children's language acquisition based on innate linguistic structures or built from cognitive and communicative skills? This book summarises the major theoretical debates in all of the core domains of child language acquisition research (phonology, word-learning, inflectional morphology, syntax and binding) and includes a complete introduction…

  7. Second Language Acquisition and Language Teaching

    ERIC Educational Resources Information Center

    Tragant, Elsa; Muñoz, Carmen

    2004-01-01

    After discussing the ties between language teaching and second language acquisition research, the present paper reviews the role that second language acquisition research has played on two recent pedagogical proposals. First, communicative language teaching, advocated in the early eighties, in which focus on the code was excluded, and then the…

  8. Studies in First and Second Language Acquisition.

    ERIC Educational Resources Information Center

    Eckman, Fred R., Ed.; Hastings, Ashley J., Ed.

    Papers presented at a 1977 symposium on language acquisition held at the University of Wisconsin/Milwaukee are included. Contents are as follows: "Assumptions, Methods and Goals in Language Acquisition Research" (Sheldon); "The Mother as LAD: Interaction between Order and Frequency of Parental Input and Child Production"…

  9. New Dimensions in Second Language Acquisition Research.

    ERIC Educational Resources Information Center

    Andersen, Roger W., Ed.

    The following papers are included: (1) "Some Common Goals for Second and First Language Acquisition Research" by Kenji Hakuta; (2) "Research on the Measurement of Affective Variables: Some Remaining Questions" by John W. Oller, Jr.; (3) "The Effects of Neurological Age on Nonprimary Language Acquisition" by Thomas…

  10. 48 CFR 1401.7001-4 - Acquisition performance measurement systems.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Acquisition performance measurement systems. 1401.7001-4 Section 1401.7001-4 Federal Acquisition Regulations System DEPARTMENT OF THE... Acquisition performance measurement systems. (a) The acquisition performance measurement system is a...

  11. 48 CFR 1401.7001-4 - Acquisition performance measurement systems.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Acquisition performance measurement systems. 1401.7001-4 Section 1401.7001-4 Federal Acquisition Regulations System DEPARTMENT OF THE... Acquisition performance measurement systems. (a) The acquisition performance measurement system is a...

  12. 48 CFR 1401.7001-4 - Acquisition performance measurement systems.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Acquisition performance measurement systems. 1401.7001-4 Section 1401.7001-4 Federal Acquisition Regulations System DEPARTMENT OF THE... Acquisition performance measurement systems. (a) The acquisition performance measurement system is a...

  13. 48 CFR 225.1101 - Acquisition of supplies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Acquisition of supplies. 225.1101 Section 225.1101 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... Contract Clauses 225.1101 Acquisition of supplies. (1) Use the provision at 252.225-7000, Buy American...

  14. 48 CFR 225.1101 - Acquisition of supplies.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Acquisition of supplies. 225.1101 Section 225.1101 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... Contract Clauses 225.1101 Acquisition of supplies. (1)(i) Use the provision at 252.225-7000, Buy...

  15. 48 CFR 27.406 - Acquisition of data.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Acquisition of data. 27.406 Section 27.406 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Data and Copyrights 27.406 Acquisition...

  16. 48 CFR 27.406-3 - Major system acquisition.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Major system acquisition. (a) The clause at 52.227-21, Technical Data Declaration, Revision, and... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Major system acquisition. 27.406-3 Section 27.406-3 Federal Acquisition Regulations System FEDERAL ACQUISITION...

  17. 48 CFR 27.406 - Acquisition of data.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Acquisition of data. 27.406 Section 27.406 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Data and Copyrights 27.406 Acquisition...

  18. 48 CFR 27.406-3 - Major system acquisition.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Major system acquisition. (a) The clause at 52.227-21, Technical Data Declaration, Revision, and... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Major system acquisition. 27.406-3 Section 27.406-3 Federal Acquisition Regulations System FEDERAL ACQUISITION...

  19. 48 CFR 27.406-3 - Major system acquisition.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Major system acquisition. (a) The clause at 52.227-21, Technical Data Declaration, Revision, and... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Major system acquisition. 27.406-3 Section 27.406-3 Federal Acquisition Regulations System FEDERAL ACQUISITION...

  20. 48 CFR 27.406 - Acquisition of data.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Acquisition of data. 27.406 Section 27.406 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Data and Copyrights 27.406 Acquisition...

  1. 48 CFR 1401.370 - Acquisition Managers' Partnership.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Acquisition Managers... Acquisition Managers' Partnership. (a) The Acquisition Managers' Partnership (AMP) is a forum for DOI's senior acquisition management community to work cooperatively and continuously to improve the management,...

  2. 48 CFR 19.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Setting aside acquisitions. 19.502 Section 19.502 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 19.502 Setting aside acquisitions....

  3. 48 CFR 1825.1101 - Acquisition of supplies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Acquisition of supplies. 1825.1101 Section 1825.1101 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Solicitation Provisions and Contract Clauses 1825.1101 Acquisition of supplies. (c)(1) NASA...

  4. 48 CFR 307.104-70 - Acquisition strategy.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... AND ACQUISITION PLANNING ACQUISITION PLANNING Acquisition Planning 307.104-70 Acquisition strategy. Program and Project Managers responsible for major IT capital investments (and for any other investments... ASFR/OGAPA/DA Internet Web site. Program and Project Managers must initiate the acquisition...

  5. 48 CFR 19.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Setting aside acquisitions. 19.502 Section 19.502 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 19.502 Setting aside acquisitions....

  6. 48 CFR 19.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Setting aside acquisitions. 19.502 Section 19.502 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 19.502 Setting aside acquisitions....

  7. 48 CFR 19.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Setting aside acquisitions. 19.502 Section 19.502 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 19.502 Setting aside acquisitions....

  8. 48 CFR 19.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Setting aside acquisitions. 19.502 Section 19.502 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 19.502 Setting aside acquisitions....

  9. 48 CFR 217.7503 - Spares acquisition integrated with production.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Spares acquisition integrated with production. 217.7503 Section 217.7503 Federal Acquisition Regulations System DEFENSE... CONTRACTING METHODS Acquisition of Replenishment Parts 217.7503 Spares acquisition integrated with...

  10. 48 CFR 217.7503 - Spares acquisition integrated with production.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Spares acquisition integrated with production. 217.7503 Section 217.7503 Federal Acquisition Regulations System DEFENSE... CONTRACTING METHODS Acquisition of Replenishment Parts 217.7503 Spares acquisition integrated with...

  11. 48 CFR 217.7503 - Spares acquisition integrated with production.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Spares acquisition integrated with production. 217.7503 Section 217.7503 Federal Acquisition Regulations System DEFENSE... CONTRACTING METHODS Acquisition of Replenishment Parts 217.7503 Spares acquisition integrated with...

  12. 48 CFR 217.7503 - Spares acquisition integrated with production.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Spares acquisition integrated with production. 217.7503 Section 217.7503 Federal Acquisition Regulations System DEFENSE... CONTRACTING METHODS Acquisition of Replenishment Parts 217.7503 Spares acquisition integrated with...

  13. Iron acquisition and regulation systems in Streptococcus species.

    PubMed

    Ge, Ruiguang; Sun, Xuesong

    2014-05-01

    Gram-positive Streptococcus species are responsible for millions of cases of meningitis, bacterial pneumonia, endocarditis, erysipelas and necrotizing fasciitis. Iron is essential for the growth and survival of Streptococcus in the host environment. Streptococcus species have developed various mechanisms to uptake iron from an environment with limited available iron. Streptococcus can directly extract iron from host iron-containing proteins such as ferritin, transferrin, lactoferrin and hemoproteins, or indirectly by relying on the employment of specialized secreted hemophores (heme chelators) and small siderophore molecules (high affinity ferric chelators). This review presents the most recent discoveries in the iron acquisition system of Streptococcus species - the transporters as well as the regulators.

  14. VLBI data, acquisition, environmental effects

    NASA Technical Reports Server (NTRS)

    Herring, Thomas A.

    1995-01-01

    During this quadrennium, very long baseline interferometry (VLBI) data acquisition and system development has focused on improving the accuracy of the system sufficiently to allow the determination of reliable estimates of height variations. Associated with this aim has been improvements in the determinations of horizontal velocity fields, monitoring water vapor delay using interferometric methods, and improvements to Earth rotation measurements. The primary aims of the improvements to height measurement accuracy have been to directly measure the contemporary magnitudes of post glacial rebound, and to determine a height reference system for measuring global sea level rise. High frequency Earth rotation studies have been carried out to better define the transformation parameters from an inertial coordinate system to an Earth fixed one, and to better understand the coupling between the components of the atmosphere-ocean-solid Earth system. Two major VLBI campaigns were carried out in support of these studies: (1) Epoch-92 in July 1992 and (2) Cont-94 in January 1994. Each of these campaigns lasted approximately two weeks and involved multiple VLBI networks operating simultaneously in addition to other space geodetic systems operating during these periods. Two major compilations of the VLBI results (and results from other space geodetic systems) have been published during this quadrennium.

  15. Multiple channel data acquisition system

    SciTech Connect

    Crawley, H. Bert; Rosenberg, Eli I.; Meyer, W. Thomas; Gorbics, Mark S.; Thomas, William D.; McKay, Roy L.; Homer, Jr., John F.

    1990-05-22

    A multiple channel data acquisition system for the transfer of large amounts of data from a multiplicity of data channels has a plurality of modules which operate in parallel to convert analog signals to digital data and transfer that data to a communications host via a FASTBUS. Each module has a plurality of submodules which include a front end buffer (FEB) connected to input circuitry having an analog to digital converter with cache memory for each of a plurality of channels. The submodules are interfaced with the FASTBUS via a FASTBUS coupler which controls a module bus and a module memory. The system is triggered to effect rapid parallel data samplings which are stored to the cache memories. The cache memories are uploaded to the FEBs during which zero suppression occurs. The data in the FEBs is reformatted and compressed by a local processor during transfer to the module memory. The FASTBUS coupler is used by the communications host to upload the compressed and formatted data from the module memory. The local processor executes programs which are downloaded to the module memory through the FASTBUS coupler.

  16. Multiple channel data acquisition system

    SciTech Connect

    Crawley, H.B.; Rosenberg, E.I.; Meyer, W.T.; Gorbics, M.S.; Thomas, W.D.; McKay, R.L.; Homer, J.F. Jr.

    1990-05-22

    A multiple channel data acquisition system for the transfer of large amounts of data from a multiplicity of data channels has a plurality of modules which operate in parallel to convert analog signals to digital data and transfer that data to a communications host via a FASTBUS. Each module has a plurality of submodules which include a front end buffer (FEB) connected to input circuitry having an analog to digital converter with cache memory for each of a plurality of channels. The submodules are interfaced with the FASTBUS via a FASTBUS coupler which controls a module bus and a module memory. The system is triggered to effect rapid parallel data samplings which are stored to the cache memories. The cache memories are uploaded to the FEBs during which zero suppression occurs. The data in the FEBs is reformatted and compressed by a local processor during transfer to the module memory. The FASTBUS coupler is used by the communications host to upload the compressed and formatted data from the module memory. The local processor executes programs which are downloaded to the module memory through the FASTBUS coupler. 25 figs.

  17. Locative terms and Warlpiri acquisition.

    PubMed

    Bavin, E L

    1990-02-01

    Cognitive complexity and complexity of linguistic structure have been found to influence the order of acquisition of locatives. In Warlpiri, locative terms are nominals and they are used in combination with a locative case marker on the reference object; directional affixes may be added to them. Data from a series of tests of Warlpiri children's comprehension and production of the Warlpiri expressions that may be translated as 'in', 'on', 'under', 'in front of', 'behind' and 'between' indicate that the locative case forms are used first without the more specific locative nominals; young children distinguish an 'up-down' dimension but not 'in', and the reference object influences how the locative term is interpreted; kamparru-pirdangirli ('front-behind') is not one dimension for children aged four to five years; kulkurru 'between' is understood before kamparru 'front' and pirdangirli 'behind'; the use of features on a reference object for orientation develops at around six, but the orientation of the reference object, as well as features on the placed object may affect interpretation.

  18. Psychological tools for knowledge acquisition

    NASA Technical Reports Server (NTRS)

    Rueter, Henry H.; Olson, Judith Reitman

    1988-01-01

    Knowledge acquisition is said to be the biggest bottleneck in the development of expert systems. The problem is getting the knowledge out of the expert's head and into a computer. In cognitive psychology, characterizing metal structures and why experts are good at what they do is an important research area. Is there some way that the tools that psychologists have developed to uncover mental structure can be used to benefit knowledge engineers? We think that the way to find out is to browse through the psychologist's toolbox to see what there is in it that might be of use to knowledge engineers. Expert system developers have relied on two standard methods for extracting knowledge from the expert: (1) the knowledge engineer engages in an intense bout of interviews with the expert or experts, or (2) the knowledge engineer becomes an expert himself, relying on introspection to uncover the basis of his own expertise. Unfortunately, these techniques have the difficulty that often the expert himself isn't consciously aware of the basis of his expertise. If the expert himself isn't conscious of how he solves problems, introspection is useless. Cognitive psychology has faced similar problems for many years and has developed exploratory methods that can be used to discover cognitive structure from simple data.

  19. Colony image acquisition and segmentation

    NASA Astrophysics Data System (ADS)

    Wang, W. X.

    2007-12-01

    For counting of both colonies and plaques, there is a large number of applications including food, dairy, beverages, hygiene, environmental monitoring, water, toxicology, sterility testing, AMES testing, pharmaceuticals, paints, sterile fluids and fungal contamination. Recently, many researchers and developers have made efforts for this kind of systems. By investigation, some existing systems have some problems. The main problems are image acquisition and image segmentation. In order to acquire colony images with good quality, an illumination box was constructed as: the box includes front lightning and back lightning, which can be selected by users based on properties of colony dishes. With the illumination box, lightning can be uniform; colony dish can be put in the same place every time, which make image processing easy. The developed colony image segmentation algorithm consists of the sub-algorithms: (1) image classification; (2) image processing; and (3) colony delineation. The colony delineation algorithm main contain: the procedures based on grey level similarity, on boundary tracing, on shape information and colony excluding. In addition, a number of algorithms are developed for colony analysis. The system has been tested and satisfactory.

  20. 77 FR 10976 - Defense Federal Acquisition Regulation Supplement; Technical Amendment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 252 Defense Federal Acquisition Regulation Supplement; Technical Amendment AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD)....

  1. 78 FR 30232 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 204 and 252 Defense Federal Acquisition Regulation Supplement; Technical Amendments AGENCY: Defense Acquisition Regulations System, Department of Defense...

  2. 78 FR 41331 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 225 Defense Federal Acquisition Regulation Supplement; Technical Amendments AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD)....

  3. 78 FR 73450 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 201, 204, 212, 216, 225, 227, and 252 Defense Federal Acquisition Regulation Supplement; Technical Amendments AGENCY: Defense Acquisition Regulations...

  4. 76 FR 13297 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 215 Defense Federal Acquisition Regulation Supplement; Technical Amendments AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD)....

  5. 48 CFR 219.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Setting aside acquisitions..., DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 219.502 Setting aside acquisitions....

  6. 48 CFR 219.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Setting aside acquisitions..., DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 219.502 Setting aside acquisitions....

  7. 48 CFR 219.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Setting aside acquisitions..., DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 219.502 Setting aside acquisitions....

  8. 48 CFR 219.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Setting aside acquisitions..., DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 219.502 Setting aside acquisitions....

  9. 48 CFR 219.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Setting aside acquisitions..., DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 219.502 Setting aside acquisitions....

  10. Iron acquisition functions expressed by the human pathogen Acinetobacter baumannii.

    PubMed

    Zimbler, Daniel L; Penwell, William F; Gaddy, Jennifer A; Menke, Sharon M; Tomaras, Andrew P; Connerly, Pamela L; Actis, Luis A

    2009-02-01

    significant differences in the iron uptake capacity between these two A. baumannii strains. Transposome mutagenesis of the strain 19606 resulted in the isolation of a derivative unable to grow under iron-chelated conditions. Gene mapping and protein analysis together with complementation assays showed that a protein related to SecA, which is a component of the Sec protein secretion system in a wide range of bacteria, is needed at least for the production of the BauA acinetobactin outer membrane receptor. Furthermore, this derivative was unable to use hemin as an iron source under limiting conditions. Taken together, these results indicate that A. baumannii expresses siderophore-mediated and hemin acquisition functions, although different isolates differ in their iron acquisition capacity. Unexpectedly, the ability of this pathogen to acquire iron depends on the expression of a SecA protein secretion function, which has not been associated with iron acquisition in bacteria.

  11. Targeted gene transfer into ependymal cells through intraventricular injection of AAV1 vector and long-term enzyme replacement via the CSF.

    PubMed

    Yamazaki, Yoshiyuki; Hirai, Yukihiko; Miyake, Koichi; Shimada, Takashi

    2014-07-01

    Enzyme replacement via the cerebrospinal fluid (CSF) has been shown to ameliorate neurological symptoms in model animals with neuropathic metabolic disorders. Gene therapy via the CSF offers a means to achieve a long-term sustainable supply of therapeutic proteins within the central nervous system (CNS) by setting up a continuous source of transgenic products. In the present study, a serotype 1 adeno-associated virus (AAV1) vector was injected into a lateral cerebral ventricle in adult mice to transduce the gene encoding human lysosomal enzyme arylsulfatase A (hASA) into the cells of the CNS. Widespread transduction and stable expression of hASA in the choroid plexus and ependymal cells was observed throughout the ventricles for more than 1 year after vector injection. Although humoral immunity to hASA developed after 6 weeks, which diminished the hASA levels detected in CSF from AAV1-injected mice, hASA levels in CSF were maintained for at least 12 weeks when the mice were tolerized to hASA prior of vector injection. Our results suggest that the cells lining the ventricles could potentially serve as a biological reservoir for long-term continuous secretion of lysosomal enzymes into the CSF following intracerebroventricular injection of an AAV1 vector.

  12. TFTR diagnostic control and data acquisition system

    SciTech Connect

    Sauthoff, N.R.; Daniels, R.E.; PPL Computer Division

    1985-05-01

    General computerized control and data-handling support for TFTR diagnostics is presented within the context of the Central Instrumentation, Control and Data Acquisition (CICADA) System. Procedures, hardware, the interactive man--machine interface, event-driven task scheduling, system-wide arming and data acquisition, and a hierarchical data base of raw data and results are described. Similarities in data structures involved in control, monitoring, and data acquisition afford a simplification of the system functions, based on ''groups'' of devices. Emphases and optimizations appropriate for fusion diagnostic system designs are provided. An off-line data reduction computer system is under development.

  13. TFTR diagnostic control and data acquisition system

    NASA Astrophysics Data System (ADS)

    Sauthoff, N. R.; Daniels, R. E.

    1985-05-01

    General computerized control and data-handling support for TFTR diagnostics is presented within the context of the Central Instrumentation, Control and Data Acquisition (CICADA) System. Procedures, hardware, the interactive man-machine interface, event-driven task scheduling, system-wide arming and data acquisition, and a hierarchical data base of raw data and results are described. Similarities in data structures involved in control, monitoring, and data acquisition afford a simplification of the system functions, based on ``groups'' of devices. Emphases and optimizations appropriate for fusion diagnostic system designs are provided. An off-line data reduction computer system is under development.

  14. A data acquisition architecture for the SSC

    SciTech Connect

    Partridge, R.

    1990-01-01

    An SSC data acquisition architecture applicable to high-p{sub T} detectors is described. The architecture is based upon a small set of design principles that were chosen to simplify communication between data acquisition elements while providing the required level of flexibility and performance. The architecture features an integrated system for data collection, event building, and communication with a large processing farm. The interface to the front end electronics system is also discussed. A set of design parameters is given for a data acquisition system that should meet the needs of high-p{sub T} detectors at the SSC.

  15. Multi-user data acquisition environment

    SciTech Connect

    Storch, N.A.

    1983-01-01

    The typical data acquisition environment involves data collection and monitoring by a single user. However, in order to support experiments on the Mars facility at Lawrence Livermore National Laboratory, we have had to create a multi-user data acquisition environment where any user can control the data acquisition and several users can monitor and analyze data being collected in real time. This paper describes how we accomplished this on an HP A600 computer. It focuses on the overall system description and user communication with the tasks within the system. Our current implementation is one phase of a long-term software development project.

  16. SSC/BCD data acquisition system proposal

    SciTech Connect

    Barsotti, E.; Bowden, M.; Swoboda, C.

    1989-04-01

    The proposed new data acquisition system architecture takes event fragments off a detector over fiber optics and to a parallel event building switch. The parallel event building switch concept, taken from the telephone communications industry, along with expected technology improvements in fiber-optic data transmission speeds over the next few years, should allow data acquisition system rates to increase dramatically and exceed those rates needed for the SSC. This report briefly describes the switch architecture and fiber optics for a SSC data acquisition system.

  17. Evaluation of Resource Acquisition Approaches : Final Report.

    SciTech Connect

    O`Neill, Maura L.; Mortimer, Tom; Palermini, Debbi; Nelson, Kari

    1991-09-12

    Over the last few years, Bonneville has been addressing this need and has developed numerous ways of acquiring resources. Four of these Approaches, the Competitive Acquisition, Billing Credits, and Targeted Acquisition Programs, and the Cowlitz Falls Hydroelectric Project, were the subject of this evaluation project. Each Approach is currently in different stages of a process, and Bonneville felt it was an appropriate time that an evaluation be conducted. The purpose of this evaluation is to analyze the various Approaches` processes, to learn what`s working and what`s not, and to offer recommendations as to how Bonneville might improve their resources acquisition efforts. The evaluation was conducted with no preconceived biases.

  18. 75 FR 51884 - Department of Education Acquisition Regulation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-23

    ...The Secretary proposes to reissue the Department of Education Acquisition Regulation (EDAR) in order to update it to accurately implement the current Federal Acquisition Regulation (FAR) and Department...

  19. Electronic Flash In Data Acquisition

    NASA Astrophysics Data System (ADS)

    Miller, C. E.

    1982-02-01

    Photographic acquisition of data often may be simplified, or the data quality improved upon by employing electronic flash sources with traditional equipment or techniques. The relatively short flash duration compared to movie camera shutters, or to the long integration time of video camera provides improved spatial resolution through blur reduction, particularly important as image movement becomes a significant fraction of film format dimension. Greater accuracy typically is achieved in velocity and acceleration determinations by using a stroboscopic light source rather than a movie camera frame-rate control as a time standard. Electrical efficiency often is an important advantage of electronic flash sources since almost any necessary light level for exposure may be produced, yet the source typically is "off" most of the time. Various synchronization techniques greatly expand the precise control of exposure. Biomechanical and sports equipment studies may involve velocities up to 200 feet-per-second, and often will have associated very rapid actions of interest. The need for brief exposures increases H.s one "ZOOMS in on the action." In golf, for example, the swing may be examined using 100 microsecond (Us) flashes at rates of 60 or 120 flashes-per-second (FPS). Accurate determination of linear and rotational velocity of the ball requires 10 Us flashes at 500-1,000 FPS, while sub-Us flashes at 20,000-50,000 FPS are required to resolve the interaction of the ball and the club, head. Some seldom. used techniques involving streak photography are described, with enhanced results obtained by combining strobe with the usual continuous light source. The combination of strobe and a fast electro-mechanical shutter is considered for Us photography under daylight conditions.

  20. Profile of altered brain iron acquisition in restless legs syndrome.

    PubMed

    Connor, James R; Ponnuru, Padmavathi; Wang, Xin-Sheng; Patton, Stephanie M; Allen, Richard P; Earley, Christopher J

    2011-04-01

    of restless legs syndrome brains. This study reveals that there are alterations in the iron management protein profile in restless legs syndrome compared with controls at the site of blood-brain interface suggesting fundamental differences in brain iron acquisition in individuals with restless legs syndrome. Furthermore, the decrease in transferrin receptor expression in the microvasculature in the presence of relative brain iron deficiency reported in restless legs syndrome brains may underlie the problems associated with brain iron acquisition in restless legs syndrome. The consistent finding of loss of iron regulatory protein activity in restless legs syndrome brain tissue further implicates this protein as a factor in the underlying cause of the iron deficiency in the restless legs syndrome brain. The data herein provide evidence for regulation of iron uptake and storage within brain microvessels that challenge the existing paradigm that the blood-brain barrier is merely a transport system.

  1. Foreign DNA acquisition by the I-F CRISPR–Cas system requires all components of the interference machinery

    PubMed Central

    Vorontsova, Daria; Datsenko, Kirill A.; Medvedeva, Sofia; Bondy-Denomy, Joseph; Savitskaya, Ekaterina E.; Pougach, Ksenia; Logacheva, Maria; Wiedenheft, Blake; Davidson, Alan R.; Severinov, Konstantin; Semenova, Ekaterina

    2015-01-01

    CRISPR immunity depends on acquisition of fragments of foreign DNA into CRISPR arrays. For type I-E CRISPR–Cas systems two modes of spacer acquisition, naïve and primed adaptation, were described. Naïve adaptation requires just two most conserved Cas1 and Cas2 proteins; it leads to spacer acquisition from both foreign and bacterial DNA and results in multiple spacers incapable of immune response. Primed adaptation requires all Cas proteins and a CRISPR RNA recognizing a partially matching target. It leads to selective acquisition of spacers from DNA molecules recognized by priming CRISPR RNA, with most spacers capable of protecting the host. Here, we studied spacer acquisition by a type I-F CRISPR–Cas system. We observe both naïve and primed adaptation. Both processes require not just Cas1 and Cas2, but also intact Csy complex and CRISPR RNA. Primed adaptation shows a gradient of acquisition efficiency as a function of distance from the priming site and a strand bias that is consistent with existence of single-stranded adaption intermediates. The results provide new insights into the mechanism of spacer acquisition and illustrate surprising mechanistic diversity of related CRISPR–Cas systems. PMID:26586803

  2. Foreign DNA acquisition by the I-F CRISPR-Cas system requires all components of the interference machinery.

    PubMed

    Vorontsova, Daria; Datsenko, Kirill A; Medvedeva, Sofia; Bondy-Denomy, Joseph; Savitskaya, Ekaterina E; Pougach, Ksenia; Logacheva, Maria; Wiedenheft, Blake; Davidson, Alan R; Severinov, Konstantin; Semenova, Ekaterina

    2015-12-15

    CRISPR immunity depends on acquisition of fragments of foreign DNA into CRISPR arrays. For type I-E CRISPR-Cas systems two modes of spacer acquisition, naïve and primed adaptation, were described. Naïve adaptation requires just two most conserved Cas1 and Cas2 proteins; it leads to spacer acquisition from both foreign and bacterial DNA and results in multiple spacers incapable of immune response. Primed adaptation requires all Cas proteins and a CRISPR RNA recognizing a partially matching target. It leads to selective acquisition of spacers from DNA molecules recognized by priming CRISPR RNA, with most spacers capable of protecting the host. Here, we studied spacer acquisition by a type I-F CRISPR-Cas system. We observe both naïve and primed adaptation. Both processes require not just Cas1 and Cas2, but also intact Csy complex and CRISPR RNA. Primed adaptation shows a gradient of acquisition efficiency as a function of distance from the priming site and a strand bias that is consistent with existence of single-stranded adaption intermediates. The results provide new insights into the mechanism of spacer acquisition and illustrate surprising mechanistic diversity of related CRISPR-Cas systems.

  3. MDS-Plus data acquisition engine

    SciTech Connect

    Flor, G. ); Cazzaro, F.; Fregonese, G.; Stangherlin, S. )

    1990-10-01

    MDS-Plus, a model driven data acquisition system being jointly developed at Istituto Gas Ionizzati, MIT Plasma Fusion Center, and Los Alamos National Laboratory, is based on the concept of an experiment model. The model contains descriptions of experiment data, devices, and actions to be performed. The data acquisition engine, i.e., the part of the system which actually executes the acquisition process, is driven by the contents of the model itself and implemented as a set of independent processes. A scheduler keeps the data acquisition engine in step with a state machine reflecting the operation of the actual experiment; a dispatcher takes care of the appropriate sequencing of the operations associated with each state of the experiment; various servers actually execute actions on behalf of the dispatcher.

  4. Mergers and acquisitions: a most strategic decision.

    PubMed

    Laine, Mike; Tyler, David

    2007-11-01

    Five steps are basic to successfully concluding (or deciding not to conclude) a merger or acquisition: Identify targets. Begin with the end in mind. Choose a transaction team. Perform due diligence. Commit to the deal--or to no deal.

  5. 48 CFR 1034.004 - Acquisition strategy.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... manager's acquisition strategy written at the system or investment level in accordance with FAR 7.103(e... team that includes a representative of the procurement organization designated in accordance...

  6. The Telecommunications and Data Acquisition Report

    NASA Technical Reports Server (NTRS)

    Posner, E. C. (Editor)

    1985-01-01

    Reports on developments in programs managed by JPL's Office of Telecommunications and Data Acquisition are presented. Emphasis is placed on activities of the Deep Space Network and its associated ground facilities.

  7. Acquisition of Crosswell Seismic Monitoring Data

    SciTech Connect

    Daley, T.M.; Niu, F.; Silver, P.G.; Majer, E.L.

    2008-02-15

    Crosswell seismic acquisition provides an ideal geometry for monitoring travel time changes in the subsurface. Analysis of delay time in terms of a characteristic frequency allows us to estimate optimal acquisition parameters (frequency and distance). We have deployed standard data acquisition equipment for continuous monitoring of crosswell travel time in two separate field experiments, with well spacing of 3 and 30 m. The acquisition hardware used for the field experiments is described, along with environmental effects (such as temperature) that influence the measurements. Two field experiments are described that correlate changes in travel time (and therefore velocity) with changes in barometric pressure. The results from the two field sites show a pressure sensitivity for velocity of 10{sup -6}/Pa to 10{sup -8}/Pa.

  8. Acoustic window planning for ultrasound acquisition.

    PubMed

    Göbl, Rüdiger; Virga, Salvatore; Rackerseder, Julia; Frisch, Benjamin; Navab, Nassir; Hennersperger, Christoph

    2017-03-11

    Autonomous robotic ultrasound has recently gained considerable interest, especially for collaborative applications. Existing methods for acquisition trajectory planning are solely based on geometrical considerations, such as the pose of the transducer with respect to the patient surface.

  9. Documents about Measurement Competency Under Acquisition Agreements

    EPA Pesticide Factsheets

    These document convey EPA policy requiring that organizations generating environmental data under Agency-funded acquisitions submit documentation of their competency, which may include participation in applicable certification and/or accreditation programs

  10. Tailoring Systems Engineering for Rapid Acquisition

    DTIC Science & Technology

    2014-03-27

    Questions With the inconsistent implementation of tailored acquisition and SE in mind , this thesis focuses on understanding which acquisition and SE...Now mind you, this might be [all during] day one. [Starting of the design process] might be day five, and we deliver at day 30. That’s how fast it...familiarity with interviewing allowed the respondents to wander off track from the questions and also to control the information flow. This limitation could

  11. Positron Emission Mammography with Multiple Angle Acquisition

    SciTech Connect

    Mark F. Smith; Stan Majewski; Raymond R. Raylman

    2002-11-01

    Positron emission mammography (PEM) of F-18 fluorodeoxyglucose (FDG) uptake in breast tumors with dedicated detectors typically has been accomplished with two planar detectors in a fixed position with the breast under compression. The potential use of PEM imaging at two detector positions to guide stereotactic breast biopsy has motivated us to use PEM coincidence data acquired at two or more detector positions together in a single image reconstruction. Multiple angle PEM acquisition and iterative image reconstruction were investigated using point source and compressed breast phantom acquisitions with 5, 9, 12 and 15 mm diameter spheres and a simulated tumor:background activity concentration ratio of 6:1. Image reconstruction was performed with an iterative MLEM algorithm that used coincidence events between any two detector pixels on opposed detector heads at each detector position. This present study compared two acquisition protocols: 2 angle acquisition with detector angular positions of -15 and +15 degrees and 11 angle acquisition with detector positions spaced at 3 degree increments over the range -15 to +15 degrees. Three- dimensional image resolution was assessed for the point source acquisitions, and contrast and signal-to-noise metrics were evaluated for the compressed breast phantom with different simulated tumor sizes. Radial and tangential resolutions were similar for the two protocols, while normal resolution was better for the 2 angle acquisition. Analysis is complicated by the asymmetric point spread functions. Signal- to-noise vs. contrast tradeoffs were better for 11 angle acquisition for the smallest visible 9 mm sphere, while tradeoff results were mixed for the larger and more easily visible 12 mm and 15 mm diameter spheres. Additional study is needed to better understand the performance of limited angle tomography for PEM. PEM tomography experiments with complete angular sampling are planned.

  12. Positron Emission Mammography with Multiple Angle Acquisition

    SciTech Connect

    Mark F. Smith; Stan Majewski; Raymond R. Raylman

    2002-11-01

    Positron emission mammography (PEM) of F-18 fluorodeoxyglucose (FbG) uptake in breast tumors with dedicated detectors typically has been accomplished with two planar detectors in a fixed position with the breast under compression. The potential use of PEM imaging at two detector positions to guide stereotactic breast biopsy has motivated us to use PEM coincidence data acquired at two or more detector positions together in a single image reconstruction. Multiple angle PEM acquisition and iterative image reconstruction were investigated using point source and compressed breast phantom acquisitions with 5, 9, 12 and 15 mm diameter spheres and a simulated tumor:background activity concentration ratio of 6:1. Image reconstruction was performed with an iterative MLEM algorithm that used coincidence events between any two detector pixels on opposed detector heads at each detector position. This present study compared two acquisition protocols: 2 angle acquisition with detector angular positions of -15 and +15 degrees and 11 angle acquisition with detector positions spaced at 3 degree increments over the range -15 to +15 degrees. Three-dimensional image resolution was assessed for the point source acquisitions, and contrast and signal-to-noise metrics were evaluated for the compressed breast phantom with different simulated tumor sizes. Radial and tangential resolutions were similar for the two protocols, while normal resolution was better for the 2 angle acquisition. Analysis is complicated by the asymmetric point spread functions. Signal- to-noise vs. contrast tradeoffs were better for 11 angle acquisition for the smallest visible 9 mm sphere, while tradeoff results were mixed for the larger and more easily visible 12 mm and 15 mm diameter spheres. Additional study is needed to better understand the performance of limited angle tomography for PEM. PEM tomography experiments with complete angular sampling are planned.

  13. Improving Acquisition Through Innovation in Workforce Incentives

    DTIC Science & Technology

    2015-04-30

    AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Defense Acquisition...University -Midwest,38219 Mound Road,Sterling Heights,MI,48310 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND... performance and schedule requirements. The acquisition system has delivered superior weapon systems with leading edge capabilities, providing a

  14. Rotor fatigue monitoring data acquisition system

    NASA Technical Reports Server (NTRS)

    Smith, Scott M.

    1993-01-01

    The 40 by 80 Foot Wind Tunnel of the National Full Scale Aerodynamics Complex (NFAC) had a requirement to monitor rotor fatigue during a test. This test subjected various rotor components to stress levels higher than their structural fatigue limits. A data acquisition system was developed to monitor the cumulative fatigue damage of rotor components using National Instruments hardware and LabVIEW software. A full description of the data acquisition system including its configuration and salient features, is presented in this paper.

  15. The Lick Observatory CCD data acquisition system

    NASA Technical Reports Server (NTRS)

    Robinson, L. B.; Stover, R. J.

    1987-01-01

    An evolving system for CCD data acquisition is described. The electronics are subdivided into those attached to the dewar, a 'smart' controller near the dewar, and a computer connected by serial link to the smart controller. Software for the smart controller is in assembler code, while the data acquisition and on-line analysis software is written in 'C' and uses the UNIX operating system.

  16. Thermal (Silicon Diode) Data Acquisition Systems

    NASA Technical Reports Server (NTRS)

    Wright, Ernest; Kegley, Jeff

    2008-01-01

    Marshall Space Flight Center s X-ray Cryogenic Facility (XRCF) has been performing cryogenic testing to 20 Kelvin since 1999. Two configurations for acquiring data from silicon diode temperature sensors have been implemented at the facility. The facility's environment is recorded via a data acquisition system capable of reading up to 60 silicon diodes. Test article temperature is recorded by a second data acquisition system capable of reading 150+ silicon diodes. The specifications and architecture of both systems will be presented.

  17. Thermal (Silicon Diode) Data Acquisition System

    NASA Technical Reports Server (NTRS)

    Kegley, Jeffrey

    2008-01-01

    Marshall Space Flight Center's X-ray Calibration Facility (XRCF) has been performing cryogenic testing to 20 Kelvin since 1999. Two configurations for acquiring data from silicon diode temperature sensors have been implemented at the facility. The facility's environment is recorded via a data acquisition system capable of reading up to 60 silicon diodes. Test article temperature is recorded by a second data acquisition system capable of reading 150+ silicon diodes. The specifications and architecture of both systems will be presented.

  18. Training Spatial Knowledge Acquisition Using Virtual Environments

    DTIC Science & Technology

    2008-02-22

    involves cognitive science, perceptual psychology, virtual- environment design, real-world training methods , etc.), it obviously requires close...97’... 4. TITLE AND SUBTITLE 5. FUNDING NUMBERS Training Spatial Knowledge Acquisition Using Virtual Environments N00014-96-1-0379 6. AUTHOR(S...KNOWLEDGE ACQUISITION USING VIRTUAL ENVIRONMENTS (1 FEBRUARY 1996 TO 31 JANUARY 1997) OF ¶ NATHANIEL I. DURLACH, ET AL., MASSACHUSETTS INSTITUTE OF

  19. Defense Acquisition Reform and Project Management

    DTIC Science & Technology

    2007-11-02

    ANSI / EIA 748 -98 Earned Value Management Systems – For now, DoD and industry EVMS criteria are equal – International discussions ongoing Canada, UK...Advantage Government Industry IBRs 32 EVMS Criteria Regulations Revised Advance Agreements IBRs ANSI - EIA 748 - Incorporate ANSI - EIA 748 in DoD...Rev. 8-98) Prescribed by ANSI Std Z39.18 DoD Acquisition Reform u The acquisition environment – Industrial base consolidation u Earned Value

  20. Department of Defense: Acquisition Rulemaking Practices

    DTIC Science & Technology

    2015-04-17

    Federal Acquisition Regulation Supplement (DFARS) rules; (2) to determine the frequency with which DOD issued final and interim rules without prior...including relevant provisions for notice and comment, for Defense Federal Acquisition Regulation Supplement (DFARS) rules; • determines the frequency ...guidance. To determine the frequency of final and interim DFARS rule issued without prior notice and comment between fiscal years 2010 and 2014, we

  1. Dynamic FLIR Target Acquisition. Phase I.

    DTIC Science & Technology

    1978-08-02

    conditions set up by the operational utilization of FLIR systems, will allow the data generated on perceptual processes to be directly applied to...variables affecting acquisition, and the definition of a study program on basic perceptual processes which have application to the operational world... processes under these conditions of image dynamics, it was decided to concentrate the research efforts on studying the observer’s target acquisition

  2. Target Acquisition and Positioning Study (TAPS)

    NASA Technical Reports Server (NTRS)

    1974-01-01

    The Scientific Instruments for the Large Space Telescope (LST) require a high degree of accuracy for positioning targets within their respective entrance apertures. The acquisition, verification of position, and guidance during an experiment must be accomplished with a minimum loss of observing time for the maximum effectiveness of the total mission. This study evaluates several viable concepts and modes of operation that are applicable for a Target Acquisition and Positioning System (TAPS) that is responsive to the LST instrument requirements.

  3. Measurement and Controls Data Acquisition System

    NASA Technical Reports Server (NTRS)

    Hall, Rick; Daniel, Alice; Batts, Frank E., Sr.

    2006-01-01

    Measurement and Controls Data Acquisition System (MCDAS) is an application program that integrates the functions of two stand-alone programs: one for acquisition of data, the other for controls. MCDAS facilitates and improves testing of complex engineering systems by helping to perform calibration and setup of test systems and acquisition, dissemination, and processing of data. Features of MCDAS include an intuitive, user-friendly graphical user interface, a capability for acquiring data at rates greater than previously possible, cooperation between the data-acquisition software subsystem and alarm-checking and analytical components of the control software subsystem, and a capability for dissemination of data through fiber optics and virtual and wide-area networks, including networks that contain hand-held display units. The integration of the data acquisition and control software offers a safety advantage by making alarm information available to the control software in a more timely manner. By enabling the use of hand-held devices, MCDAS reduces the time spent by technicians asking for screen updates to determine effects of setup actions. Previously recorded data can be processed without interruption to current acquisition of data. Analysts can continue to view test parameters while test-data files are being generated.

  4. Joystick acquisition in tufted capuchins (Cebus apella).

    PubMed

    Leighty, Katherine A; Fragaszy, Dorothy M

    2003-09-01

    A number of nonhuman primate species have demonstrated the ability to use a joystick to control a cursor on a computer screen, yet the acquisition of this skill has not been the focus of systematic inquiry. Here, we examined joystick acquisition in four tufted capuchins under two directional relationships of joystick movement and resultant cursor displacement, isomorphic and inverted. To document the natural history of the acquisition of this skill, we recorded the development of visual tracking of the cursor and body tilting. Rates of acquisition were comparable between the two conditions. After mastering the task in one condition, subjects remastered the task at an accelerated rate in the opposing condition. All subjects significantly increased or maintained high proportions of cursor tracking throughout acquisition. All subjects demonstrated a postural tilt while moving the cursor from the mid-phase of acquisition through task mastery. In the isomorphic condition, all subjects tilted significantly more often in the direction of goal location than in the opposite direction. In three of the four series of tilting that were scored for subjects in the inverted condition, tilting occurred significantly more often toward the direction of goal location than the direction of required hand movement. Together these findings suggest that body tilting participates in the organization of directional movement of the cursor rather than reflecting merely the motoric requirements of the task (to manipulate a joystick).

  5. Updated NGNP Fuel Acquisition Strategy

    SciTech Connect

    David Petti; Tim Abram; Richard Hobbins; Jim Kendall

    2010-12-01

    A Next Generation Nuclear Plant (NGNP) fuel acquisition strategy was first established in 2007. In that report, a detailed technical assessment of potential fuel vendors for the first core of NGNP was conducted by an independent group of international experts based on input from the three major reactor vendor teams. Part of the assessment included an evaluation of the credibility of each option, along with a cost and schedule to implement each strategy compared with the schedule and throughput needs of the NGNP project. While credible options were identified based on the conditions in place at the time, many changes in the assumptions underlying the strategy and in externalities that have occurred in the interim requiring that the options be re-evaluated. This document presents an update to that strategy based on current capabilities for fuel fabrication as well as fuel performance and qualification testing worldwide. In light of the recent Pebble Bed Modular Reactor (PBMR) project closure, the Advanced Gas Reactor (AGR) fuel development and qualification program needs to support both pebble and prismatic options under the NGNP project. A number of assumptions were established that formed a context for the evaluation. Of these, the most important are: • Based on logistics associated with the on-going engineering design activities, vendor teams would start preliminary design in October 2012 and complete in May 2014. A decision on reactor type will be made following preliminary design, with the decision process assumed to be completed in January 2015. Thus, no fuel decision (pebble or prismatic) will be made in the near term. • Activities necessary for both pebble and prismatic fuel qualification will be conducted in parallel until a fuel form selection is made. As such, process development, fuel fabrication, irradiation, and testing for pebble and prismatic options should not negatively influence each other during the period prior to a decision on reactor type

  6. 48 CFR 1825.1101 - Acquisition of supplies.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Acquisition of supplies. 1825.1101 Section 1825.1101 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Solicitation Provisions and Contract Clauses...

  7. A Research on Second Language Acquisition and College English Teaching

    ERIC Educational Resources Information Center

    Li, Changyu

    2009-01-01

    It was in the 1970s that American linguist S.D. Krashen created the theory of "language acquisition". The theories on second language acquisition were proposed based on the study on the second language acquisition process and its rules. Here, the second language acquisition process refers to the process in which a learner with the…

  8. 48 CFR 227.7103-2 - Acquisition of technical data.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Acquisition of technical data. 227.7103-2 Section 227.7103-2 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND...

  9. 48 CFR 227.7103-2 - Acquisition of technical data.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Acquisition of technical data. 227.7103-2 Section 227.7103-2 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND...

  10. 48 CFR 227.7103-2 - Acquisition of technical data.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Acquisition of technical data. 227.7103-2 Section 227.7103-2 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND...

  11. 48 CFR 227.7103-2 - Acquisition of technical data.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Acquisition of technical data. 227.7103-2 Section 227.7103-2 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND...

  12. 48 CFR 227.7103-2 - Acquisition of technical data.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Acquisition of technical data. 227.7103-2 Section 227.7103-2 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND...

  13. 48 CFR 1319.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Setting aside acquisitions. 1319.502 Section 1319.502 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 1319.502 Setting aside acquisitions....

  14. 48 CFR 819.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Setting aside acquisitions. 819.502 Section 819.502 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 819.502 Setting aside acquisitions....

  15. 48 CFR 25.1101 - Acquisition of supplies.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... such a determination, the contracting officer must follow agency procedures. (2) Insert the provision... SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Solicitation Provisions and Contract Clauses 25.1101 Acquisition of supplies. The following provisions and clauses apply to the acquisition of supplies and the acquisition...

  16. Analyzing the Structure of Air Force Space Acquisitions

    DTIC Science & Technology

    2006-12-01

    51 viii III. CASE STUDY APPLICATION ...............................................................................53 A. CHAPTER...discussed throughout this research paper . Acquisition Arm is defined as the entity in charge of the acquisition of space assets and systems. Air...phase Evolutionary Acquisition or Single Step to Full Capability FRP Decision Review FOC LRIP/ IOT &E Design Readiness Review Pre-Systems Acquisition

  17. 48 CFR 1319.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Setting aside acquisitions. 1319.502 Section 1319.502 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 1319.502 Setting aside acquisitions....

  18. 48 CFR 819.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Setting aside acquisitions. 819.502 Section 819.502 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 819.502 Setting aside acquisitions....

  19. 48 CFR 919.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Setting aside acquisitions. 919.502 Section 919.502 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 919.502 Setting aside acquisitions....

  20. 48 CFR 1319.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Setting aside acquisitions. 1319.502 Section 1319.502 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 1319.502 Setting aside acquisitions....

  1. 48 CFR 3419.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Setting aside acquisitions. 3419.502 Section 3419.502 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 3419.502...

  2. 48 CFR 3419.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 7 2014-10-01 2014-10-01 false Setting aside acquisitions. 3419.502 Section 3419.502 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 3419.502...

  3. 48 CFR 3419.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 7 2012-10-01 2012-10-01 false Setting aside acquisitions. 3419.502 Section 3419.502 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 3419.502...

  4. 48 CFR 919.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Setting aside acquisitions. 919.502 Section 919.502 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 919.502 Setting aside acquisitions....

  5. 48 CFR 819.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Setting aside acquisitions. 819.502 Section 819.502 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 819.502 Setting aside acquisitions....

  6. 48 CFR 3419.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 7 2011-10-01 2011-10-01 false Setting aside acquisitions. 3419.502 Section 3419.502 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 3419.502...

  7. 48 CFR 1319.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Setting aside acquisitions. 1319.502 Section 1319.502 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 1319.502 Setting aside acquisitions....

  8. 48 CFR 1319.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Setting aside acquisitions. 1319.502 Section 1319.502 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 1319.502 Setting aside acquisitions....

  9. 48 CFR 919.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Setting aside acquisitions. 919.502 Section 919.502 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 919.502 Setting aside acquisitions....

  10. 48 CFR 819.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Setting aside acquisitions. 819.502 Section 819.502 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 819.502 Setting aside acquisitions....

  11. 48 CFR 919.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Setting aside acquisitions. 919.502 Section 919.502 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 919.502 Setting aside acquisitions....

  12. 48 CFR 819.502 - Setting aside acquisitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Setting aside acquisitions. 819.502 Section 819.502 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 819.502 Setting aside acquisitions....

  13. 48 CFR 217.7503 - Spares acquisition integrated with production.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Spares acquisition integrated with production. 217.7503 Section 217.7503 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES...

  14. 10 CFR 626.5 - Acquisition procedures-general.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DEPARTMENT OF ENERGY (CONTINUED) SALES REGULATION PROCEDURES FOR ACQUISITION OF PETROLEUM FOR THE STRATEGIC PETROLEUM RESERVE § 626.5 Acquisition procedures—general. (a) Notice of acquisition. (1) Except when DOE has... acquire petroleum for the SPR. The notice of acquisition is usually in the form of a solicitation....

  15. 10 CFR 626.5 - Acquisition procedures-general.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DEPARTMENT OF ENERGY (CONTINUED) SALES REGULATION PROCEDURES FOR ACQUISITION OF PETROLEUM FOR THE STRATEGIC PETROLEUM RESERVE § 626.5 Acquisition procedures—general. (a) Notice of acquisition. (1) Except when DOE has... acquire petroleum for the SPR. The notice of acquisition is usually in the form of a solicitation....

  16. 10 CFR 626.4 - General acquisition strategy.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... DEPARTMENT OF ENERGY (CONTINUED) SALES REGULATION PROCEDURES FOR ACQUISITION OF PETROLEUM FOR THE STRATEGIC PETROLEUM RESERVE § 626.4 General acquisition strategy. (a) Criteria for commencing acquisition. To reduce... prior to commencing acquisition of petroleum for the SPR: (1) The current inventory of the SPR; (2)...

  17. 10 CFR 626.4 - General acquisition strategy.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... DEPARTMENT OF ENERGY (CONTINUED) SALES REGULATION PROCEDURES FOR ACQUISITION OF PETROLEUM FOR THE STRATEGIC PETROLEUM RESERVE § 626.4 General acquisition strategy. (a) Criteria for commencing acquisition. To reduce... prior to commencing acquisition of petroleum for the SPR: (1) The current inventory of the SPR; (2)...

  18. 10 CFR 626.5 - Acquisition procedures-general.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DEPARTMENT OF ENERGY (CONTINUED) SALES REGULATION PROCEDURES FOR ACQUISITION OF PETROLEUM FOR THE STRATEGIC PETROLEUM RESERVE § 626.5 Acquisition procedures—general. (a) Notice of acquisition. (1) Except when DOE has... acquire petroleum for the SPR. The notice of acquisition is usually in the form of a solicitation....

  19. 10 CFR 626.4 - General acquisition strategy.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DEPARTMENT OF ENERGY (CONTINUED) SALES REGULATION PROCEDURES FOR ACQUISITION OF PETROLEUM FOR THE STRATEGIC PETROLEUM RESERVE § 626.4 General acquisition strategy. (a) Criteria for commencing acquisition. To reduce... prior to commencing acquisition of petroleum for the SPR: (1) The current inventory of the SPR; (2)...

  20. 10 CFR 626.4 - General acquisition strategy.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DEPARTMENT OF ENERGY (CONTINUED) SALES REGULATION PROCEDURES FOR ACQUISITION OF PETROLEUM FOR THE STRATEGIC PETROLEUM RESERVE § 626.4 General acquisition strategy. (a) Criteria for commencing acquisition. To reduce... prior to commencing acquisition of petroleum for the SPR: (1) The current inventory of the SPR; (2)...

  1. 10 CFR 626.4 - General acquisition strategy.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DEPARTMENT OF ENERGY (CONTINUED) SALES REGULATION PROCEDURES FOR ACQUISITION OF PETROLEUM FOR THE STRATEGIC PETROLEUM RESERVE § 626.4 General acquisition strategy. (a) Criteria for commencing acquisition. To reduce... prior to commencing acquisition of petroleum for the SPR: (1) The current inventory of the SPR; (2)...

  2. 10 CFR 626.5 - Acquisition procedures-general.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... DEPARTMENT OF ENERGY (CONTINUED) SALES REGULATION PROCEDURES FOR ACQUISITION OF PETROLEUM FOR THE STRATEGIC PETROLEUM RESERVE § 626.5 Acquisition procedures—general. (a) Notice of acquisition. (1) Except when DOE has... acquire petroleum for the SPR. The notice of acquisition is usually in the form of a solicitation....

  3. 77 FR 10665 - General Services Administration Acquisition Regulation; Acquisition-Related Thresholds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-23

    ... Acquisition Regulation (GSAR) to update the acquisition- related thresholds in two GSAR clauses. DATES...-related thresholds, the GSAR clause at 552.219-71, Notice to Offerors of Subcontracting Plan Requirements...'' and ``$1,500,000'', respectively. The GSAR clause at 552.219-72, Preparation, Submission,...

  4. Acquisition Management for System of Systems: Requirement Evolution and Acquisition Strategy Planning

    DTIC Science & Technology

    2013-01-29

    inefficiencies and warranted the pursuit of better systems engineering practices to encompass SoS principles. The recognition of the need for improved...important for providing acquisition groups with the means of performing acquisition, integration, and development decision-making in the mist of evolving

  5. 77 FR 23371 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-58; Small Entity Compliance Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-18

    ... the rule appearing in Federal Acquisition Circular (FAC) 2005-58, which amends the Federal Acquisition... prepared. Interested parties may obtain further information regarding this rule by referring to FAC 2005-58..., contact the analyst whose name appears in the table below. Please cite FAC 2005-58 and the FAR case...

  6. 77 FR 69726 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-62; Small Entity Compliance Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-20

    ... the rule appearing in Federal Acquisition Circular (FAC) 2005-62, which amends the Federal Acquisition... prepared. Interested parties may obtain further information regarding this rule by referring to FAC 2005-62..., contact the analyst whose name appears in the table below. Please cite FAC 2005-62 and the FAR case...

  7. 76 FR 4187 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-49; Introduction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-24

    ... Acquisition Regulation (FAR) rules agreed to by DOD, GSA, and NASA in this Federal Acquisition Circular (FAC) 2005-49. A companion document, the Small Entity Compliance Guide (SECG), follows this FAC. The FAC... in the table below in relation to each FAR case. Please cite FAC 2005-49 and the specific FAR...

  8. 77 FR 23363 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-58; Introduction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-18

    ... Acquisition Regulations Council (Councils) in this Federal Acquisition Circular (FAC) 2005-58. A companion document, the Small Entity Compliance Guide (SECG), follows this FAC. The FAC, including the SECG, is... table below in relation to each FAR case. Please cite FAC 2005-58 and the specific FAR case numbers....

  9. 78 FR 13769 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-66; Small Entity Compliance Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ... the rule appearing in Federal Acquisition Circular (FAC) 2005-66, which amends the Federal Acquisition... prepared. Interested parties may obtain further information regarding this rule by referring to FAC 2005-66..., contact the analyst whose name appears in the table below. Please cite FAC 2005-66 and the FAR case...

  10. 77 FR 75780 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-64; Small Entity Compliance Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-21

    ... the rule appearing in Federal Acquisition Circular (FAC) 2005-64, which amends the Federal Acquisition... prepared. Interested parties may obtain further information regarding this rule by referring to FAC 2005-64... CONTACT: The analyst whose name appears in the table below in relation to the FAR case. Please cite...

  11. 78 FR 38533 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-68; Introduction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ... Defense Acquisition Regulations Council (Councils) in this Federal Acquisition Circular (FAC) 2005-68. A companion document, the Small Entity Compliance Guide (SECG), follows this FAC. The FAC, including the SECG... appears in the table below in relation to the FAR case. Please cite FAC 2005-68 and the specific FAR...

  12. 78 FR 6192 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-65; Small Entity Compliance Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ... the rule appearing in Federal Acquisition Circular (FAC) 2005-65, which amends the Federal Acquisition... prepared. Interested parties may obtain further information regarding this rule by referring to FAC 2005-65..., contact the analyst whose name appears in the table below. Please cite FAC 2005-65 and the FAR case...

  13. 78 FR 38537 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-68; Small Entity Compliance Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ... the rule appearing in Federal Acquisition Circular (FAC) 2005-68, which amends the Federal Acquisition... prepared. Interested parties may obtain further information regarding this rule by referring to FAC 2005-68... the analyst whose name appears in the table below. Please cite FAC 2005-68 and the FAR case...

  14. 77 FR 73515 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-63; Introduction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-10

    ... Acquisition Regulations Council (Councils) in this Federal Acquisition Circular (FAC) 2005-63. A companion document, the Small Entity Compliance Guide (SECG), follows this FAC. The FAC, including the SECG, is... table below. Please cite FAC 2005-63 and the specific FAR case number. For information pertaining...

  15. 76 FR 4191 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-49; Small Entity Compliance Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-24

    ... rules appearing in Federal Acquisition Circular (FAC) 2005-49, which amend the Federal Acquisition Regulation (FAR). Interested parties may obtain further information regarding these rules by referring to FAC... CONTACT: The analyst whose name appears in the table below. Please cite FAC 2005-49 and the specific...

  16. 78 FR 6183 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-65; Introduction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ... Defense Acquisition Regulations Council (Councils) in this Federal Acquisition Circular (FAC) 2005-65. A companion document, the Small Entity Compliance Guide (SECG), follows this FAC. The FAC, including the SECG... appears in the table below in relation to each FAR case. Please cite FAC 2005-65 and the specific FAR...

  17. 77 FR 73520 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-63; Small Entity Compliance Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-10

    ... the rule appearing in Federal Acquisition Circular (FAC) 2005-63, which amends the Federal Acquisition... prepared. Interested parties may obtain further information regarding this rule by referring to FAC 2005-63..., contact the analyst whose name appears in the table below. Please cite FAC 2005-63 and the FAR case...

  18. 77 FR 69713 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-62; Introduction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-20

    ... Acquisition Regulations Council (Councils) in this Federal Acquisition Circular (FAC) 2005-62. A companion document, the Small Entity Compliance Guide (SECG), follows this FAC. The FAC, including the SECG, is... table below in relation to each FAR case. Please cite FAC 2005-62 and the specific FAR case numbers....

  19. 78 FR 13763 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-66; Introduction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ... Defense Acquisition Regulations Council (Councils) in this Federal Acquisition Circular (FAC) 2005-66. A companion document, the Small Entity Compliance Guide (SECG), follows this FAC. The FAC, including the SECG... appears in the table below in relation to each FAR case. Please cite FAC 2005-66 and the specific FAR...

  20. 78 FR 37698 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-67; Small Entity Compliance Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-21

    ... the rule appearing in Federal Acquisition Circular (FAC) 2005-67, which amends the Federal Acquisition... prepared. Interested parties may obtain further information regarding this rule by referring to FAC 2005-67... the analyst whose name appears in the table below. Please cite FAC 2005-67 and the FAR case...

  1. 76 FR 18324 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-51; Small Entity Compliance Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-01

    ... rules appearing in Federal Acquisition Circular (FAC) 2005-51, which amend the Federal Acquisition... prepared. Interested parties may obtain further information regarding these rules by referring to FAC 2005... CONTACT: The analyst whose name appears in the table below. Please cite FAC 2005-51 and the specific...

  2. 78 FR 37684 - Federal Acquisition Regulation; Interagency Acquisitions: Compliance by Nondefense Agencies With...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-21

    ... (OFPP) and Federal Procurement Data System (FPDS) policy regarding the allocation of socio-economic... 9000-AM36 Federal Acquisition Regulation; Interagency Acquisitions: Compliance by Nondefense Agencies..., GSA, and NASA are adopting as final, with changes, an interim rule amending the Federal...

  3. 78 FR 38234 - Defense Federal Acquisition Regulation Supplement: Requirements for Acquisitions Pursuant to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ... convention. Delete 216.501-1. Only ``Multiple-award contract'' was defined and it was only used in 216.505-70... Acquisition Regulation Supplement: Requirements for Acquisitions Pursuant to Multiple Award Contracts (DFARS... pursuant to multiple award contracts. Increasing savings in expenditures through competition is...

  4. 77 FR 27551 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-59; Small Entity Compliance Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ...This document is issued under the joint authority of DOD, GSA, and NASA. This Small Entity Compliance Guide has been prepared in accordance with section 212 of the Small Business Regulatory Enforcement Fairness Act of 1996. It consists of a summary of the rule appearing in Federal Acquisition Circular (FAC) 2005-59, which amends the Federal Acquisition Regulation (FAR). Interested parties may......

  5. Grammatical Acquisition: Inductive Bias and Coevolution of Language and the Language Acquisition Device.

    ERIC Educational Resources Information Center

    Briscoe, Ted

    2000-01-01

    An account of grammatical acquisition is developed within the parameter setting framework applied to a generalized categorical grammar (GCG). Computational simulation shows that several resulting acquisition procedures are effective on a parameter set expressing major typological distinctions based on constituent order, and defining 70 distinct…

  6. 78 FR 13544 - Defense Federal Acquisition Regulation Supplement: Acquisition of Tents and Other Temporary...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ... Acquisition Regulation Supplement: Acquisition of Tents and Other Temporary Structures (DFARS Case 2012-D015... other temporary structures. DATES: Effective February 28, 2013. FOR FURTHER INFORMATION CONTACT: Fernell... contracts that provide the best value, when acquiring tents and other temporary structures, regardless...

  7. Societal Responses to Adult Difficulties in L2 Acquisition: Toward an Evolutionary Perspective on Language Acquisition

    ERIC Educational Resources Information Center

    Schumann, John H.

    2013-01-01

    It is generally accepted that second language (L2) acquisition becomes more difficult as one grows older and that success in adult L2 acquisition is highly variable. Nevertheless, humans in language contact situations have to cope with intergroup communication. This article examines the ways society has responded to this challenge. It describes…

  8. 48 CFR 246.404 - Government contract quality assurance for acquisitions at or below the simplified acquisition...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... quality assurance for acquisitions at or below the simplified acquisition threshold. 246.404 Section 246... DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.404 Government contract quality assurance for acquisitions at or below the simplified acquisition threshold. Do...

  9. 76 FR 58149 - Defense Federal Acquisition Regulation Supplement; Ships Bunkers Easy Acquisition (SEA) Card® and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... Regulation Supplement; Ships Bunkers Easy Acquisition (SEA) Card and Aircraft Ground Services (DFARS Case... to the simplified acquisition threshold using the Ships Bunkers Easy Acquisition (SEA) Card in lieu... fuel using the Ships' bunkers Easy Acquisition (SEA) Card in lieu of the SF44, Purchase...

  10. A Method for Aligning Acquisition Strategies and Software Architectures

    DTIC Science & Technology

    2014-09-01

    the rate of failure of “ big bang ” acquisitions, the size and expected cost led to the decision that there should be two separate acquisitions, one...Goal: wants the program to avoid a “ big bang ” acquisition since these have often led to fail- ing programs (related to acquisition quality attribute of...program survivability) Stimulus: the PEO is made aware of the rate of failure of “ big bang ” acquisitions Environment: before program inception

  11. Sequential acquisition of multi-dimensional heteronuclear chemical shift correlation spectra with 1H detection

    NASA Astrophysics Data System (ADS)

    Bellstedt, Peter; Ihle, Yvonne; Wiedemann, Christoph; Kirschstein, Anika; Herbst, Christian; Görlach, Matthias; Ramachandran, Ramadurai

    2014-03-01

    RF pulse schemes for the simultaneous acquisition of heteronuclear multi-dimensional chemical shift correlation spectra, such as {HA(CA)NH & HA(CACO)NH}, {HA(CA)NH & H(N)CAHA} and {H(N)CAHA & H(CC)NH}, that are commonly employed in the study of moderately-sized protein molecules, have been implemented using dual sequential 1H acquisitions in the direct dimension. Such an approach is not only beneficial in terms of the reduction of experimental time as compared to data collection via two separate experiments but also facilitates the unambiguous sequential linking of the backbone amino acid residues. The potential of sequential 1H data acquisition procedure in the study of RNA is also demonstrated here.

  12. Sequential acquisition of multi-dimensional heteronuclear chemical shift correlation spectra with 1H detection

    PubMed Central

    Bellstedt, Peter; Ihle, Yvonne; Wiedemann, Christoph; Kirschstein, Anika; Herbst, Christian; Görlach, Matthias; Ramachandran, Ramadurai

    2014-01-01

    RF pulse schemes for the simultaneous acquisition of heteronuclear multi-dimensional chemical shift correlation spectra, such as {HA(CA)NH & HA(CACO)NH}, {HA(CA)NH & H(N)CAHA} and {H(N)CAHA & H(CC)NH}, that are commonly employed in the study of moderately-sized protein molecules, have been implemented using dual sequential 1H acquisitions in the direct dimension. Such an approach is not only beneficial in terms of the reduction of experimental time as compared to data collection via two separate experiments but also facilitates the unambiguous sequential linking of the backbone amino acid residues. The potential of sequential 1H data acquisition procedure in the study of RNA is also demonstrated here. PMID:24671105

  13. DAQMAN - A flexible configurable data acquisition system

    SciTech Connect

    Sivertz, Michael; Larry Hoff, Seth Nemesure

    2012-08-01

    DAQMAN is a flexible configurable interface that allows the user to build and operate a VME-based data acquisition system on a Linux workstation. It consists of two parts: a Java-based Graphical User Interface to configure the system, and a C-based utility that reads out the data and creates the output ASCII data file, with two levels of diagnostic tools. The data acquisition system requires a CAEN CONET-VME Bridge to communicate between the hardware in the VME crate and the Linux workstation. Data acquisition modules, such as ADCs, TDC, Scalers, can be loaded into the system, or removed easily. The GUI allows users to activate modules, and channels within modules by clicking on icons. Running configurations are stored; data are collected and can be viewed either as raw numbers, or by charts and histograms that update as the data are accumulated. Data files are written to disk in ASCII format, with a date and time stamp.

  14. Magnetic Field Response Measurement Acquisition System

    NASA Technical Reports Server (NTRS)

    Woodard, Stanley E.; Taylor, Bryant D.; Shams, Qamar A.; Fox, Robert L.

    2005-01-01

    A measurement acquisition method that alleviates many shortcomings of traditional measurement systems is presented in this paper. The shortcomings are a finite number of measurement channels, weight penalty associated with measurements, electrical arcing, wire degradations due to wear or chemical decay and the logistics needed to add new sensors. The key to this method is the use of sensors designed as passive inductor-capacitor circuits that produce magnetic field responses. The response attributes correspond to states of physical properties for which the sensors measure. A radio frequency antenna produces a time-varying magnetic field used to power the sensor and receive the magnetic field response of the sensor. An interrogation system for discerning changes in the sensor response is presented herein. Multiple sensors can be interrogated using this method. The method eliminates the need for a data acquisition channel dedicated to each sensor. Methods of developing magnetic field response sensors and the influence of key parameters on measurement acquisition are discussed.

  15. Implicit learning and acquisition of music.

    PubMed

    Rohrmeier, Martin; Rebuschat, Patrick

    2012-10-01

    Implicit learning is a core process for the acquisition of a complex, rule-based environment from mere interaction, such as motor action, skill acquisition, or language. A body of evidence suggests that implicit knowledge governs music acquisition and perception in nonmusicians and musicians, and that both expert and nonexpert participants acquire complex melodic, harmonic, and other features from mere exposure. While current findings and computational modeling largely support the learning of chunks, some results indicate learning of more complex structures. Despite the body of evidence, more research is required to support the cross-cultural validity of implicit learning and to show that core and more complex music theoretical features are acquired implicitly.

  16. Hunger promotes acquisition of nonfood objects

    PubMed Central

    Xu, Alison Jing; Schwarz, Norbert; Wyer, Robert S.

    2015-01-01

    Hunger motivates people to consume food, for which finding and acquiring food is a prerequisite. We test whether the acquisition component spills over to nonfood objects: Are hungry people more likely to acquire objects that cannot satisfy their hunger? Five laboratory and field studies show that hunger increases the accessibility of acquisition-related concepts and the intention to acquire not only food but also nonfood objects. Moreover, people act on this intention and acquire more nonfood objects (e.g., binder clips) when they are hungry, both when these items are freely available and when they must be paid for. However, hunger does not influence how much they like nonfood objects. We conclude that a basic biologically based motivation can affect substantively unrelated behaviors that cannot satisfy the motivation. This presumably occurs because hunger renders acquisition-related concepts and behaviors more accessible, which influences decisions in situations to which they can be applied. PMID:25730858

  17. Optimisation of acquisition time in bioluminescence imaging

    NASA Astrophysics Data System (ADS)

    Taylor, Shelley L.; Mason, Suzannah K. G.; Glinton, Sophie; Cobbold, Mark; Styles, Iain B.; Dehghani, Hamid

    2015-03-01

    Decreasing the acquisition time in bioluminescence imaging (BLI) and bioluminescence tomography (BLT) will enable animals to be imaged within the window of stable emission of the bioluminescent source, a higher imaging throughput and minimisation of the time which an animal is anaesthetised. This work investigates, through simulation using a heterogeneous mouse model, two methods of decreasing acquisition time: 1. Imaging at fewer wavelengths (a reduction from five to three); and 2. Increasing the bandwidth of filters used for imaging. The results indicate that both methods are viable ways of decreasing the acquisition time without a loss in quantitative accuracy. Importantly, when choosing imaging wavelengths, the spectral attenuation of tissue and emission spectrum of the source must be considered, in order to choose wavelengths at which a high signal can be achieved. Additionally, when increasing the bandwidth of the filters used for imaging, the bandwidth must be accounted for in the reconstruction algorithm.

  18. Description of the ACCESS data acquisition system

    SciTech Connect

    Treichel, B.A.; Koehl, E.R.

    1983-09-01

    The ACCESS data acquisition system is designed to acquire, process, and store samples of analog data produced by the Reversing Flow Test Apparatus. Data acquisition requires minimal interaction with the user, being governed primarily by trigger pulses generated in a shaft encoder coupled to a camshaft in the apparatus. A complete scan of 32 input data channels is made 18 times per camshaft revolution at speeds up to 30 revolutions per second. At higher speeds, up to the maximum apparatus speed of 50 revolutions per second, data channels are scanned 9 times per revolution. The programs for this data acquisition system are written for the Hewlett-Packard MCU 2250 measurement and control processor, operating in conjunction with an HP-1000 system computer.

  19. Hunger promotes acquisition of nonfood objects.

    PubMed

    Xu, Alison Jing; Schwarz, Norbert; Wyer, Robert S

    2015-03-03

    Hunger motivates people to consume food, for which finding and acquiring food is a prerequisite. We test whether the acquisition component spills over to nonfood objects: Are hungry people more likely to acquire objects that cannot satisfy their hunger? Five laboratory and field studies show that hunger increases the accessibility of acquisition-related concepts and the intention to acquire not only food but also nonfood objects. Moreover, people act on this intention and acquire more nonfood objects (e.g., binder clips) when they are hungry, both when these items are freely available and when they must be paid for. However, hunger does not influence how much they like nonfood objects. We conclude that a basic biologically based motivation can affect substantively unrelated behaviors that cannot satisfy the motivation. This presumably occurs because hunger renders acquisition-related concepts and behaviors more accessible, which influences decisions in situations to which they can be applied.

  20. Minimum acquisition time detection. [of radar targets

    NASA Technical Reports Server (NTRS)

    Brock, H. I.; Hung, J. C.

    1975-01-01

    Two different methods of target detection when the return signal is contaminated with noise are discussed and compared. The first method uses Neyman-Pearson detection philosophy and selects the threshold level to give a desired false alarm probability. The maximum probability of false alarm is constrained by the target cross scan velocity component. The second method (minimum acquisition time detection), which is similar to the ideal observer, selects the threshold level to minimize the expected target acquisition time. The probabilities of false alarm and missed detection are selected so that the errors produced by these effects produce the minimum acquisition time. Three different scan techniques - linear, spiral and two-mode scan - are studied and compared.

  1. Sample Acquisition Techniques for Exobiology Flight Experiments

    NASA Technical Reports Server (NTRS)

    Kojiro, Daniel R.; Carle, Glenn C.; Stratton, David M.; Valentin, Jose R.; DeVincenzi, Donald (Technical Monitor)

    1999-01-01

    Exobiology Flight Experiments involve complex analyses conducted in environments far different than those encountered in terrestrial applications. A major part of the analytical challenge is often the selection, acquisition, delivery and, in some cases, processing of a sample suitable for the analytical requirements of the mission. The added complications of severely limited resources and sometimes rigid time constraints combine to make sample acquisition potentially a major obstacle for successful analyses. Potential samples come in a wide range including planetary atmospheric gas and aerosols (from a wide variety of pressures), planetary soil or rocks, dust and ice particles streaming off of a comet, and cemetery surface ice and rocks. Methods to collect and process sample are often mission specific, requiring continual development of innovative concepts and mechanisms. These methods must also maintain the integrity of the sample for the experimental results to be meaningful. We present here sample acquisition systems employed from past missions and proposed for future missions.

  2. Data Acquisition System for Instructional Spectroscopes

    NASA Astrophysics Data System (ADS)

    Almeida, C. B. S. B.; Hetem, A.

    2014-10-01

    This article aims to present the software for data acquisition developed in scientific initiation program - IC, for use in the design of a spectrometer built by students. The program was built in C++, a language in wide use today. The origin of spectra used is a simplified model of rustic spectroscope. This equipment basically consists of a box that does not allow light to enter, except through a slit made in the side of it, a diffraction media and a camera for data acquisition. After the image acquisition, one executes the data processing, followed by the usual steps of reduction and analysis of this type of tool. We have implemented a method for calibrating the spectroscope, through which one can compare the incidence of the photons with characteristic of each monochromatic wave. The final result is a one-dimensional spectrum that can be subsequently analyzed.

  3. Data acquisition at a residential photovoltaic system

    NASA Astrophysics Data System (ADS)

    McIntyre, J. M.; Miller, G. N.

    A description is presented of the techniques employed for data collection and analysis in the study of a small residential photovoltaic (PV) system. A model home of approximately 139 sq m incorporated a PV array on the south-facing roof. The PV system was designed to interface directly to the local utility system through an inverter which converted the direct current output of the array to 60 Hz alternating current. Electric power could flow either from the utility lines into the house or vice versa. The solar panel consisted of 120 modules installed in a 5 x 24 array. Attention is given to initial problems, the conduction of a systems analysis, the data collection method, the equipment used in the data acquisition system, aspects of data collection, the encountered problems, and the results of the data acquisition project. It was found that the data acquisition system employed was effective for computer-compatible data collection.

  4. Evolutionary analysis of iron (Fe) acquisition system in Marchantia polymorpha.

    PubMed

    Lo, Jing-Chi; Tsednee, Munkhtsetseg; Lo, Ying-Chu; Yang, Shun-Chung; Hu, Jer-Ming; Ishizaki, Kimitsune; Kohchi, Takayuki; Lee, Der-Chuen; Yeh, Kuo-Chen

    2016-07-01

    To acquire appropriate iron (Fe), vascular plants have developed two unique strategies, the reduction-based strategy I of nongraminaceous plants for Fe(2+) and the chelation-based strategy II of graminaceous plants for Fe(3+) . However, the mechanism of Fe uptake in bryophytes, the earliest diverging branch of land plants and dominant in gametophyte generation is less clear. Fe isotope fractionation analysis demonstrated that the liverwort Marchantia polymorpha uses reduction-based Fe acquisition. Enhanced activities of ferric chelate reductase and proton ATPase were detected under Fe-deficient conditions. However, M. polymorpha did not show mugineic acid family phytosiderophores, the key components of strategy II, or the precursor nicotianamine. Five ZIP (ZRT/IRT-like protein) homologs were identified and speculated to be involved in Fe uptake in M. polymorpha. MpZIP3 knockdown conferred reduced growth under Fe-deficient conditions, and MpZIP3 overexpression increased Fe content under excess Fe. Thus, a nonvascular liverwort, M. polymorpha, uses strategy I for Fe acquisition. This system may have been acquired in the common ancestor of land plants and coopted from the gametophyte to sporophyte generation in the evolution of land plants.

  5. Interactive specification acquisition via scenarios: A proposal

    NASA Technical Reports Server (NTRS)

    Hall, Robert J.

    1992-01-01

    Some reactive systems are most naturally specified by giving large collections of behavior scenarios. These collections not only specify the behavior of the system, but also provide good test suites for validating the implemented system. Due to the complexity of the systems and the number of scenarios, however, it appears that automated assistance is necessary to make this software development process workable. Interactive Specification Acquisition Tool (ISAT) is a proposed interactive system for supporting the acquisition and maintenance of a formal system specification from scenarios, as well as automatic synthesis of control code and automated test generation. This paper discusses the background, motivation, proposed functions, and implementation status of ISAT.

  6. Magic-angle turning with double acquisition

    NASA Astrophysics Data System (ADS)

    Matsunaga, Tatsuya; Takegoshi, K.

    2017-01-01

    The double-acquisition scheme for efficient data collection of hypercomplex data (the States method) of a two-dimensional experiment is adopted to magic-angle hopping (MAH) and magic-angle turning (MAT) experiments, which are powerful methods to measure the principal values of the chemical shift anisotropy (CSA) in a powder sample. It is shown that the double acquisition MAT (DAMAT) sequence realizes the S/N ratio comparable to or better than those of other variants of the MAH/MAT sequences. In addition, we show that DAMAT has preferable features that there are no spinning sidebands in the indirect dimension, and no spectral shearing is necessary.

  7. Linking Acquisition Decisionmaking With National Military Strategy

    DTIC Science & Technology

    1990-10-01

    ICopy .17 of 146 copie; !1 AD-A235 445 I IDA REPORT R-366 LINKING ACQUISITION DECISIONMAKING I WITH NATIONAL MILITARY STRATEGY David R. Graham...National Military Strategy C-MDA-903 89 C0003 TA-T-G6-678 6. AUTHOR(S) David R. Graham, Herschel E. Kanter, Martin J. Ralley, Barbara A. Blcksler...executing acquisition programs that are consistent with national military strategy and projected budgets. Next it reviews the long-standing concerns with

  8. CO2 Acquisition Membrane (CAM) Project

    NASA Technical Reports Server (NTRS)

    Mason, L. W.; Way, J. D.; Vlasse, M.

    2001-01-01

    The CO2 Acquisition Membrane (CAM) project will develop, test, and analyze membrane materials for separation and purification of carbon dioxide (CO2) from mixtures of gases, such as those found in the Martian atmosphere. The CAM technology will enable passive separation of these gases, allow energy efficient acquisition and purification of these important resources, and lay the foundation for future unmanned sample return and human space missions. The CAM membranes are targeted toward In Situ Resource Utilization (ISRU) applications, such as In Situ Propellant Production (ISPP) and In Situ Consumables Production (ISCP).

  9. The data acquisition system for SLD

    SciTech Connect

    Sherden, D.J.

    1986-10-01

    This paper describes the data acquisition system planned for the SLD detector, which is being constructed for use with the SLAC Linear Collider (SLC). Analog electronics, heavily incorporating hybrid and custom VLSI circuitry, is mounted on the detector itself. Extensive use is made of multiplexing through optical fibers to a FASTBUS readout system. The low repetition rate of the SLC allows a relatively simple software-based trigger. Hardware and software processors within the acquisition modules are used to reduce the large volume of data per event and to calibrate the electronics. A farm of microprocessors is used for full reconstruction of a sample of events prior to transmission to the host.

  10. Magic-angle turning with double acquisition.

    PubMed

    Matsunaga, Tatsuya; Takegoshi, K

    2017-01-01

    The double-acquisition scheme for efficient data collection of hypercomplex data (the States method) of a two-dimensional experiment is adopted to magic-angle hopping (MAH) and magic-angle turning (MAT) experiments, which are powerful methods to measure the principal values of the chemical shift anisotropy (CSA) in a powder sample. It is shown that the double acquisition MAT (DAMAT) sequence realizes the S/N ratio comparable to or better than those of other variants of the MAH/MAT sequences. In addition, we show that DAMAT has preferable features that there are no spinning sidebands in the indirect dimension, and no spectral shearing is necessary.

  11. Preschool foundations of early reading acquisition

    PubMed Central

    Rvachew, Susan; Savage, Robert

    2006-01-01

    The present paper describes research on the skills and processes associated with word and text reading acquisition in preschool children and during the first years of school. The aim is to provide an overview that gives a sense of the important milestones in language and literacy acquisition. A comparison of children’s performances against these milestones may thus guide effective intervention for health professionals, parents and other professionals. Also summarized and explored are the role of speech perception and production, grammatical and syntactic skills, and metacognitive skills, including phonological awareness. PMID:19030330

  12. Modulated Acquisition of Spatial Distortion Maps

    PubMed Central

    Volkov, Alexey; Gros, Jerneja Žganec; Žganec, Mario; Javornik, Tomaž; Švigelj, Aleš

    2013-01-01

    This work discusses a novel approach to image acquisition which improves the robustness of captured data required for 3D range measurements. By applying a pseudo-random code modulation to sequential acquisition of projected patterns the impact of environmental factors such as ambient light and mutual interference is significantly reduced. The proposed concept has been proven with an experimental range sensor based on the laser triangulation principle. The proposed design can potentially enhance the use of this principle to a variety of outdoor applications, such as autonomous vehicles, pedestrians' safety, collision avoidance, and many other tasks, where robust real-time distance detection in real world environment is crucial. PMID:23966196

  13. Draft Automatic Data Acquisition System Plan

    SciTech Connect

    Not Available

    1987-04-01

    This Automatic Data Acquisition System (ADAS) Plan has been prepared in support of the requirement for detailed site characterization of the Deaf Smith County candidate repository site in salt, and describes the data acquisition system which will be used for unattended data collection from the geotechnical instrumentation installed at the site. Section 1.1 discusses the programmatic background to the plan, Section 1.2 presents the scope and purpose of the plan, and the organization of the document is given in Section 1.3. 31 refs., 34 figs., 8 tabs.

  14. A Synopsis of Acquisition Related Topics.

    DTIC Science & Technology

    1983-03-01

    Direct labor N/A N/A 5-15 ver bead N/A N/A 4-6 Other Genral Management 6-8 6-8 -8 CONT.ACTCR RISK 0-8 0-7 0-4 FACILITIES INVESTMENT 16-20 N/I N/ SPECIAL...Acquisition Contracts Management *, Procurement Contracting Cost Accounting 2. ASTMACT (CAN@"*OMW - 040 itO. d a.u "Moo FWef 06- -> Managers and potential... managers in the acquisition field should find this thesis to be a useful tool. It initiates development of a single reference that will provide a synopsis

  15. Acquisition and Role of Molybdate in Pseudomonas aeruginosa

    PubMed Central

    Pederick, Victoria G.; Eijkelkamp, Bart A.; Ween, Miranda P.; Begg, Stephanie L.; Paton, James C.

    2014-01-01

    In microaerophilic or anaerobic environments, Pseudomonas aeruginosa utilizes nitrate reduction for energy production, a process dependent on the availability of the oxyanionic form of molybdenum, molybdate (MoO42−). Here, we show that molybdate acquisition in P. aeruginosa occurs via a high-affinity ATP-binding cassette permease (ModABC). ModA is a cluster D-III solute binding protein capable of interacting with molybdate or tungstate oxyanions. Deletion of the modA gene reduces cellular molybdate concentrations and results in inhibition of anaerobic growth and nitrate reduction. Further, we show that conditions that permit nitrate reduction also cause inhibition of biofilm formation and an alteration in fatty acid composition of P. aeruginosa. Collectively, these data highlight the importance of molybdate for anaerobic growth of P. aeruginosa and reveal novel consequences of nitrate reduction on biofilm formation and cell membrane composition. PMID:25172858

  16. Acquisition and role of molybdate in Pseudomonas aeruginosa.

    PubMed

    Pederick, Victoria G; Eijkelkamp, Bart A; Ween, Miranda P; Begg, Stephanie L; Paton, James C; McDevitt, Christopher A

    2014-11-01

    In microaerophilic or anaerobic environments, Pseudomonas aeruginosa utilizes nitrate reduction for energy production, a process dependent on the availability of the oxyanionic form of molybdenum, molybdate (MoO4 (2-)). Here, we show that molybdate acquisition in P. aeruginosa occurs via a high-affinity ATP-binding cassette permease (ModABC). ModA is a cluster D-III solute binding protein capable of interacting with molybdate or tungstate oxyanions. Deletion of the modA gene reduces cellular molybdate concentrations and results in inhibition of anaerobic growth and nitrate reduction. Further, we show that conditions that permit nitrate reduction also cause inhibition of biofilm formation and an alteration in fatty acid composition of P. aeruginosa. Collectively, these data highlight the importance of molybdate for anaerobic growth of P. aeruginosa and reveal novel consequences of nitrate reduction on biofilm formation and cell membrane composition.

  17. Mandatory Procedures for Major Defense Acquisition Programs (MDAPS) and Major Automated Information System (MAIS) Acquisition Programs

    DTIC Science & Technology

    2002-04-05

    ACQUISITION STRATEGY 32 C2.8. SUPPORT STRATEGY 34 DoD 5000.2-R, April 5, 2002 TABLE OF CONTENTS 5 C2.9. BUSINESS STRATEGY 40 C3. CHAPTER 3 TEST AND...AL1.1.110. PA&E Program Analysis and Evaluation AL1.1.111. PAUC Program Acquisition Unit Cost AL1.1.112. PBBE Performance-Based Business Environment...Simulation-Based Acquisition AL1.1.132. SBIR Small Business Innovation Research AL1.1.133. SEI Software Engineering Institute AL1.1.134. SSAA System

  18. Information Acquisition in Children Undergoing Medical Procedures.

    ERIC Educational Resources Information Center

    Melamed, Barbara G.; And Others

    In order to evaluate how individual characteristics of hospitalized children influence their acquisition of information presented in a film depicting preparation for surgery, 42 children between the ages of 4 to 17 were assigned to experimental and control groups that were matched for age, sex, race, type of surgery and previous hospital…

  19. The telecommunications and data acquisition report

    NASA Technical Reports Server (NTRS)

    Renzetti, N. A.

    1980-01-01

    Deep Space Network progress in flight project support, tracking and data acquisition research and technology, network engineering, hardware and software implemention, and operations is documented. In addition, developments in Earth based radio technology as applied to geodynamics, astrophysics, and the radio search for extraterrestrial intelligence are reported.

  20. 43 CFR 3837.20 - Acquisition.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Acquisition. 3837.20 Section 3837.20 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) ACQUIRING A DELINQUENT CO-CLAIMANT'S INTERESTS IN...

  1. 43 CFR 3837.20 - Acquisition.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Acquisition. 3837.20 Section 3837.20 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) ACQUIRING A DELINQUENT CO-CLAIMANT'S INTERESTS IN...

  2. 43 CFR 3837.20 - Acquisition.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Acquisition. 3837.20 Section 3837.20 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) ACQUIRING A DELINQUENT CO-CLAIMANT'S INTERESTS IN...

  3. 43 CFR 3837.20 - Acquisition.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Acquisition. 3837.20 Section 3837.20 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) ACQUIRING A DELINQUENT CO-CLAIMANT'S INTERESTS IN...

  4. Second Language Acquisition Theory and Pedagogy.

    ERIC Educational Resources Information Center

    Eckman, Fred R., Ed.; And Others

    Selected papers on second language acquisition and instruction from the University of Wisconsin at Madison symposium include the following: "Learning and Teaching: The Necessary Intersection" (Susan M. Gass); "Reenvisioning the Second Language Classroom: A Vygotskian Approach" (Linda Schinke-Llano); "The FOCAL SKILLS…

  5. Can Communicative Principles Enhance Classical Language Acquisition?

    ERIC Educational Resources Information Center

    Overland, Paul; Fields, Lee; Noonan, Jennifer

    2011-01-01

    Is it feasible for nonfluent instructors to teach Biblical Hebrew by communicative principles? If it is feasible, will communicative instruction enhance postsecondary learning of a classical language? To begin answering these questions, two consultants representing second language acquisition (SLA) and technology-assisted language learning led 8…

  6. Sociocultural Theory and Second Language Acquisition

    ERIC Educational Resources Information Center

    Lantolf, James P.; Beckett, Tracy G.

    2009-01-01

    Second language acquisition (SLA) research informed by sociocultural theory (henceforth, SCT) began in earnest with the publication of Frawley & Lantolf's (1985) article on L2 (second language) discourse (described in the timeline proper). Since then, well over 300 journal articles, book chapters and doctoral dissertations have appeared in the…

  7. Helicopter External Load Acquisition Technology Investigation.

    DTIC Science & Technology

    1980-12-01

    101st Airborne Division, Fort Campbell, Ky. Evergreen Helicopters, McMinnville , Oregon The Army Technical Representative for the program was Mr. Richard...commercial helicopter operator, Evergreen Helicopters, McMinnville , Oregon, to obtain additional data on commercial solutions to external load acquisition

  8. Facilitation and Practice in Verb Acquisition

    ERIC Educational Resources Information Center

    Keren-Portnoy, Tamar

    2006-01-01

    This paper presents a model of syntax acquisition, whose main points are as follows: Syntax is acquired in an item-based manner; early learning facilitates subsequent learning--as evidenced by the accelerating rate of new verbs entering a given structure; and mastery of syntactic knowledge is typically achieved through practice--as evidenced by…

  9. Electro-Optic Data Acquisition and Processing.

    DTIC Science & Technology

    Methods for the analysis of electro - optic relaxation data are discussed. Emphasis is on numerical methods using high speed computers. A data acquisition system using a minicomputer for data manipulation is described. Relationship of the results obtained here to other possible uses is given. (Author)

  10. 36 CFR 230.8 - Acquisition requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Acquisition requirements. 230.8 Section 230.8 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE STATE AND PRIVATE FORESTRY ASSISTANCE Community Forest and Open Space Conservation Program §...

  11. 36 CFR 230.8 - Acquisition requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Acquisition requirements. 230.8 Section 230.8 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE STATE AND PRIVATE FORESTRY ASSISTANCE Community Forest and Open Space Conservation Program §...

  12. 36 CFR 230.8 - Acquisition requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Acquisition requirements. 230.8 Section 230.8 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE STATE AND PRIVATE FORESTRY ASSISTANCE Community Forest and Open Space Conservation Program §...

  13. Mergers and acquisitions involving equine veterinary practices.

    PubMed

    Jackman, Brad R; McCafferty, Owen E

    2009-12-01

    This article discusses mergers and acquisitions involving equine veterinary practices. Combining practices can be professionally and economically advantageous but requires a great deal of thought, planning, and implementation. If due diligence is performed and true business teamwork is undertaken, the benefits can be enormous and rewarding.

  14. The Telecommunications and Data Acquisition Report

    NASA Technical Reports Server (NTRS)

    Posner, E. C. (Editor)

    1983-01-01

    Archival reports on developments in programs managed by JPL's office of Telecommunications and Data Acquisition (TDA) are presented. In space communications, radio navigation, radio science, and ground-based radio astronomy, it reports on activities of the Deep Space Network (DSN) and its associated Ground Communications Facility (GCF) in planning, in supporting research and technology, in implementation, and in operations.

  15. Communicative Tactics in Children's Second Language Acquisition.

    ERIC Educational Resources Information Center

    Saville-Troike, M.; And Others

    The development and use of verbal and nonverbal communication by children in the early stages of second language acquisition were investigated in a natural setting. Twenty young speakers of Japanese, Korean, Hebrew, Spanish, Icelandic, and Polish, enrolled in a multilingual program and ranging in age from 7 to 12 years, served as subjects. All of…

  16. Collection Development/Acquisitions: Collaboration or Conflict?

    ERIC Educational Resources Information Center

    Clement, Mercedes

    At the Daytona Beach Community College (DBCC) Library, collection development, selection, and acquisitions function as levels of a hierarchy. The highest level is collection development, which constitutes the planning function. Meetings are held annually to assess user needs, evaluate the present collection, discuss budget considerations, plan for…

  17. NASA Data Acquisitions System (NDAS) Software Architecture

    NASA Technical Reports Server (NTRS)

    Davis, Dawn; Duncan, Michael; Franzl, Richard; Holladay, Wendy; Marshall, Peggi; Morris, Jon; Turowski, Mark

    2012-01-01

    The NDAS Software Project is for the development of common low speed data acquisition system software to support NASA's rocket propulsion testing facilities at John C. Stennis Space Center (SSC), White Sands Test Facility (WSTF), Plum Brook Station (PBS), and Marshall Space Flight Center (MSFC).

  18. Foreign Language Acquisition and Melody Singing.

    ERIC Educational Resources Information Center

    Mora, Carmen Fonseca

    2000-01-01

    Considers the value of relating music and language in the English-as-Foreign-Language (EFL) classroom. This "melodic" approach is based on evidence that musicality of speech has an effect not only on the pronunciation skills of EFL students but also their entire acquisition process. (Author/VWL)

  19. 32 CFR 644.88 - Other acquisition.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... submission of declaration of taking assemblies in appropriate instances. (2) Acquisition of grazing rights. (i) Grazing rights in the public domain are granted pursuant to the provisions of a series of Congressional acts commonly referred to as the Taylor Grazing Act, 43 U.S.C. 315 et seq. Section 315q of...

  20. 32 CFR 644.88 - Other acquisition.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... (2) Acquisition of grazing rights. (i) Grazing rights in the public domain are granted pursuant to the provisions of a series of Congressional acts commonly referred to as the Taylor Grazing Act, 43 U... prevents its use for grazing, persons holding grazing permits or licenses and persons whose grazing...

  1. 32 CFR 644.88 - Other acquisition.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... submission of declaration of taking assemblies in appropriate instances. (2) Acquisition of grazing rights. (i) Grazing rights in the public domain are granted pursuant to the provisions of a series of Congressional acts commonly referred to as the Taylor Grazing Act, 43 U.S.C. 315 et seq. Section 315q of...

  2. 32 CFR 644.88 - Other acquisition.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... (2) Acquisition of grazing rights. (i) Grazing rights in the public domain are granted pursuant to the provisions of a series of Congressional acts commonly referred to as the Taylor Grazing Act, 43 U... prevents its use for grazing, persons holding grazing permits or licenses and persons whose grazing...

  3. 32 CFR 644.88 - Other acquisition.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... submission of declaration of taking assemblies in appropriate instances. (2) Acquisition of grazing rights. (i) Grazing rights in the public domain are granted pursuant to the provisions of a series of Congressional acts commonly referred to as the Taylor Grazing Act, 43 U.S.C. 315 et seq. Section 315q of...

  4. Grapheme-Phoneme Acquisition of Deaf Preschoolers

    ERIC Educational Resources Information Center

    Beal-Alvarez, Jennifer S.; Lederberg, Amy R.; Easterbrooks, Susan R.

    2012-01-01

    We examined acquisition of grapheme-phoneme correspondences by 4 deaf and hard-of-hearing preschoolers using instruction from a curriculum designed specifically for this population supplemented by Visual Phonics. Learning was documented through a multiple baseline across content design as well as descriptive analyses. Preschoolers who used sign…

  5. Incidental Foreign Language Acquisition from Media Exposure

    ERIC Educational Resources Information Center

    Kuppens, An H.

    2010-01-01

    A number of experimental studies have demonstrated the incidental acquisition of a foreign language by children and adolescents when watching foreign language television. While such experiments can only establish short-term effects, this article investigates the extent to which children's foreign language skills benefit from their long-term…

  6. Dual Learning Processes in Interactive Skill Acquisition

    ERIC Educational Resources Information Center

    Fu, Wai-Tat; Anderson, John R.

    2008-01-01

    Acquisition of interactive skills involves the use of internal and external cues. Experiment 1 showed that when actions were interdependent, learning was effective with and without external cues in the single-task condition but was effective only with the presence of external cues in the dual-task condition. In the dual-task condition, actions…

  7. The Telecommunications and Data Acquisition Report

    NASA Technical Reports Server (NTRS)

    Posner, E. C. (Editor)

    1986-01-01

    This publication, one of a series formerly titled The Deep Space Network (DSN) Progress Report, documents DSN progress in flight project support, tracking and data acquisition research and technology, network engineering, hardware and software implementation, and operations. In addition, developments in Earth-based radio technology as applied to geodynamics, astrophysics, and the radio search for extraterrestrial intelligence are reported.

  8. Hypertext Interface Design and Structural Knowledge Acquisition.

    ERIC Educational Resources Information Center

    Koneman, Philip A.; Jonassen, David H.

    Hypertext is well-suited for educational applications where open learning and knowledge exploration is desired. In such applications, principles of good hypertext interface design should be employed to avoid navigational problems so as to maximize learning. Interface design, however, may also directly enhance acquisition of a particular knowledge…

  9. Toward More Substantial Theories of Language Acquisition

    ERIC Educational Resources Information Center

    Jenson, Cinnamon Ann

    2015-01-01

    Cognitive linguists argue that certain sets of knowledge of language are innate. However, critics have argued that the theoretical concept of "innateness" should be eliminated since it is ambiguous and insubstantial. In response, I aim to strengthen theories of language acquisition and identify ways to make them more substantial. I…

  10. Data-Acquisition System For Rotor Vibrations

    NASA Technical Reports Server (NTRS)

    Posta, Stephen J.; Brown, Gerald V.

    1988-01-01

    New system trades hardware for software to reduce cost. Composite train of interspersed blade-detection pulses produced by gates at four probe ports on data-acquisition board. Pulses latch count from high-speed wraparound clock counter and initiate writing of count onto current address of memory. Result: time corresponding to each blade passage stamped into memory.

  11. Data Acquisition System(DAS) Sustaining Engineering

    NASA Technical Reports Server (NTRS)

    1998-01-01

    This paper presents general information describing the Data Acquisition System contract, a summary of objectives, tasks performed and completed. The hardware deliverables which are comprised of: 1) Two ground DAS units; 2) Two flight DAS units; 3) Logistic spares; and 4) Shipping containers are described. Also included are the data requirements and scope of the contract.

  12. 32 CFR 644.7 - Acquisition lines.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Acquisition lines. 644.7 Section 644.7 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE..., in accordance with sound real estate practices. Accordingly, fringe tracts will not be acquired...

  13. Magnetic Field Response Measurement Acquisition System

    NASA Technical Reports Server (NTRS)

    Woodard, Stanley E.; Taylor,Bryant D.; Shams, Qamar A.; Fox, Robert L.

    2007-01-01

    This paper presents a measurement acquisition method that alleviates many shortcomings of traditional measurement systems. The shortcomings are a finite number of measurement channels, weight penalty associated with measurements, electrical arcing, wire degradations due to wear or chemical decay and the logistics needed to add new sensors. Wire degradation has resulted in aircraft fatalities and critical space launches being delayed. The key to this method is the use of sensors designed as passive inductor-capacitor circuits that produce magnetic field responses. The response attributes correspond to states of physical properties for which the sensors measure. Power is wirelessly provided to the sensing element by using Faraday induction. A radio frequency antenna produces a time-varying magnetic field used to power the sensor and receive the magnetic field response of the sensor. An interrogation system for discerning changes in the sensor response frequency, resistance and amplitude has been developed and is presented herein. Multiple sensors can be interrogated using this method. The method eliminates the need for a data acquisition channel dedicated to each sensor. The method does not require the sensors to be near the acquisition hardware. Methods of developing magnetic field response sensors and the influence of key parameters on measurement acquisition are discussed. Examples of magnetic field response sensors and the respective measurement characterizations are presented. Implementation of this method on an aerospace system is discussed.

  14. Analysis of an antijam FH acquisition scheme

    NASA Astrophysics Data System (ADS)

    Miller, Leonard E.; Lee, Jhong S.; French, Robert H.; Torrieri, Don J.

    1992-01-01

    An easily implemented matched filter scheme for acquiring hopping code synchronization of incoming frequency-hopping (FH) signals is analyzed, and its performance is evaluated for two types of jamming: partial-band noise jamming and partial-band multitone jamming. The system is designed to reduce jammer-induced false alarms. The system's matched-filter output is compared to an adaptive threshold that is derived from a measurement of the number of acquisition channels being jammed. Example performance calculations are given for the frequency coverage of the jamming either fixed over the entire acquisition period or hopped, that is, changed for each acquisition pulse. It is shown that the jammer's optimum strategy (the worst case) is to maximize the false-alarm probability without regard for the effect on detection probability, for both partial-band noise and multi-tone jamming. It is also shown that a significantly lower probability of false acquisition results from using an adaptive matched-filter threshold, demonstrating that the strategy studied here is superior to conventional nonadaptive threshold schemes.

  15. The Telecommunications and Data Acquisition Report

    NASA Technical Reports Server (NTRS)

    Posner, E. C. (Editor)

    1985-01-01

    Deep Space Network (DSN) progress in flight project support, tracking and data acquisition research and technology, network engineering, hardware and software implementation, and operation is discussed. In addition, developments in Earth-based radio technology as applied to geodynamics, astrophysics and the radio search for extraterrestrial intelligence are reported.

  16. Acquisition in USTRANSCOM: An Organizational Assessment

    DTIC Science & Technology

    2009-12-01

    in the Harvard Business Review, a team’s success or failure at collaborating reflects the philosophy of top executives in the organization ( Gratton ...improvement act: Five years later. Acquisition Review Quarterly, summer, 1–21. Gratton , L., & Erickson, T.J. (2007). 8 ways to build collaborative teams

  17. Cultural Universals in the Acquisition of Language.

    ERIC Educational Resources Information Center

    Ochs, Elinor

    It is proposed that there are cultural universals in the use of language and that these universals have implications for language acquisition. The model rests on three hypotheses: (1) there are culturally universal tendencies in the linguistic marking of four dimensions of language (epistemic and affective stances, social acts, social activities,…

  18. 75 FR 43090 - Federal Acquisition Regulation; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-23

    ... Federal Acquisition Regulation; Correction AGENCY: Department of Defense (DoD), General Services... issuing a correction to FAR Case 2010-008, Recovery Act Subcontract Reporting Procedures (Item III), which.... Please cite FAC 2005-43; Correction. SUPPLEMENTARY INFORMATION: Background DoD, GSA and NASA published...

  19. 76 FR 76899 - Federal Acquisition Regulation; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-09

    ...; Correction; FAR Case 2011-014; Docket 2011-0014; Sequence 1] RIN 9000-AM11 Federal Acquisition Regulation; Correction AGENCIES: Department of Defense (DoD), General Services Administration (GSA), and National... corrections to the final rule which was published in the Federal Register of Wednesday, November 2, 2011...

  20. Acquisition Order of Coherence Relations in Turkish

    ERIC Educational Resources Information Center

    Demirgunes, Sercan

    2015-01-01

    Coherence as one of the criteria for textuality is the main element of a well-produced text. In the literature, there are many studies on the classification of coherence relations. Although there are different classifications on coherence relations, similar findings are reported regarding the acquisition order of coherence relations in different…

  1. Processes Involved in Acquisition of Cognitive Skills.

    ERIC Educational Resources Information Center

    Christensen, Carol A.; Bain, John

    Processes involved in the acquisition of cognitive skills were studied through an investigation of the efficacy of initially encoding knowledge of a cognitive skill in either declarative or procedural form. Subjects were 80 university students. The cognitive skill, learning the steps to program a simulated video cassette recorder (VCR), was taught…

  2. Resource-Bounded Information Acquisition and Learning

    DTIC Science & Technology

    2012-05-01

    45] apply the theory of value of information, but their method is mostly restricted to chain graphical models. Golovin et al. [33] tackle the problem...for information acquisition from large and redundant data. Tech. Rep. arXiv:1012.3502, Dec 2010. [33] Golovin , Daniel, Krause, Andreas, and Ray

  3. Problems in the Acquisition of Grammatical Tone.

    ERIC Educational Resources Information Center

    Demuth, Katherine

    An autosegmental account of the child's acquisition of grammatical tone in Sesotho, a southern Bantu language, is presented. The following theoretical questions are addressed: (1) When and how does the child figure out that Sesotho is a tonal rather than intonational, stress, or accentual language?; (2) How does the child acquire tonal rules?; and…

  4. Commercial Practices for Defense Acquisition Guidebook

    DTIC Science & Technology

    1992-01-01

    acquisitions through adoption of Navy. Shipbuilding and Logistics). The commercial practices. same is tnie of the " beso practices" 12 Chapter I...similarities between commercial Operated Civil Enit-ineer Supply Store supply and Government inventory management automotive and civil engineering paris

  5. Storytelling: Enhancing Language Acquisition in Young Children.

    ERIC Educational Resources Information Center

    Speaker, Kathryne McGrath; Taylor, Deborah; Kamen, Ruth

    2004-01-01

    We know that children are active participants in their acquisition of language. Their language patterns are learned in social contexts while they are interacting with other children and adults. Studies continue to confirm that the development of vocabulary and syntactic complexity in language are more advanced in children who are frequently…

  6. Virtue Acquisition: The Paradox of Striving

    ERIC Educational Resources Information Center

    Snow, Nancy

    2016-01-01

    Aristotelian-inspired accounts of virtue acquisition stress guided practice and habituated action to develop virtue. This emphasis on action can lead to the "paradox of striving". The paradox occurs when we try too hard to act well and thereby spoil our efforts. I identify four forms of striving--forcing, impulsivity, overthinking, and…

  7. Linguistic Perspectives from Spanish Second Language Acquisition.

    ERIC Educational Resources Information Center

    Carpenter, Mark, Ed.; Koike, Dale April, Ed.

    1998-01-01

    Papers reporting research on Spanish second language learning include: "Discourse Features of Spanish Oral Production at the Novice Level" (Rebecca Jo Bearden); "A Discourse Approach to the Assessment of Foreign Language Oral Proficiency" (Dale April Koike, Fanny Hinojosa); "Acquisition of Spanish Definite Articles by English-Speaking Learners of…

  8. Acquisition Strategies for Dealing with Uncertainty

    DTIC Science & Technology

    2009-04-22

    management (Loch, DeMeyer & Pich , 2006), product development (Smith, 2007) and venture capital (Gompers & Lerner, 2001: Stevens, King & Halley, 2008...2009). The weapons systems acquisition reform act of 2009 (S.454). Proposed legislation. Loch, C.H., De Meyer, A., & Pich , M. (2006). Managing the

  9. Dis-integrating Perspectives of Language Acquisition.

    ERIC Educational Resources Information Center

    Jacobs, Bob

    1995-01-01

    Responds to L. Eubank and K. R. Gregg article (this issue), suggesting they have misinterpreted and misrepresented claims made by B. Jacobs and J. Schumann. Claims discussed include the micro- and macro-organization of neurobiology and language, the Explananda, Jacobs and Schumann's acquisition mechanism, and reductionism. The single acquisition…

  10. Cerebral Dominance, Language Acquisition, and Foreign Accents.

    ERIC Educational Resources Information Center

    Scovel, Tom

    1969-01-01

    Implicit in the discussion of views taken by Wolfe, Geschwind, and Newmark is a claim that no learning theory based solely on "nurture" can account for the fact that language acquisition in childhood is a trait, in adulthood a skill. The child can master the language system completely, regardless of his intellectual capacity or his social…

  11. Second Language Acquisition and Applied Linguistics.

    ERIC Educational Resources Information Center

    Larsen-Freeman, Diane

    2000-01-01

    Discusses the second language acquisition (SLA) process and the differential success of second language learners. Examines the fundamental challenges that this characterization faces, and highlights the contributions SLA is capable of in the coming decade. Offers topics for a training and development of curriculum for future applied linguists from…

  12. Guidelines for dynamic data acquisition and analysis

    NASA Technical Reports Server (NTRS)

    Piersol, Allan G.

    1992-01-01

    The recommendations concerning pyroshock data presented in the final draft of a proposed military handbook on Guidelines for Dynamic Data Acquisition and Analysis are reviewed. The structural responses produced by pyroshocks are considered to be one of the most difficult types of dynamic data to accurately measure and analyze.

  13. Guidelines for dynamic data acquisition and analysis

    NASA Astrophysics Data System (ADS)

    Piersol, Allan G.

    1992-10-01

    The recommendations concerning pyroshock data presented in the final draft of a proposed military handbook on Guidelines for Dynamic Data Acquisition and Analysis are reviewed. The structural responses produced by pyroshocks are considered to be one of the most difficult types of dynamic data to accurately measure and analyze.

  14. Naturalistic acquisition in an early language classroom.

    PubMed

    Dahl, Anne; Vulchanova, Mila D

    2014-01-01

    This study investigated whether it is possible to provide naturalistic second language acquisition (SLA) of vocabulary for young learners in a classroom situation without resorting to a classical immersion approach. Participants were 60 first-grade pupils in two Norwegian elementary schools in their first year. The control group followed regular instruction as prescribed by the school curriculum, while the experimental group received increased naturalistic target language input. This entailed extensive use of English by the teacher during English classes, and also during morning meetings and for simple instructions and classroom management throughout the day. Our hypothesis was that it is possible to facilitate naturalistic acquisition through better quality target language exposure within a normal curriculum. The students' English vocabulary knowledge was measured using the Peabody Picture Vocabulary Test, version 4 (PPVT-IV, Dunn and Dunn, 2007a), at the beginning and the end of the first year of school. Findings are that (1) early-start second-language (L2) programs in school do not in themselves guarantee vocabulary development in the first year, (2) a focus on increased exposure to the L2 can lead to a significant increase in receptive vocabulary comprehension in the course of only 8 months, and (3) even with relatively modest input, learners in such an early-start L2 program can display vocabulary acquisition comparable in some respects to that of younger native children matched on vocabulary size. The overall conclusion is that naturalistic vocabulary acquisition is in fact possible in a classroom setting.

  15. Ultrasonic Scanner Control and Data Acquisition

    NASA Technical Reports Server (NTRS)

    Hemann, John

    2002-01-01

    The research accomplishments under this grant were very extensive in the areas of ULTRASONIC SCANNER CONTROL AND DATA ACQUISITION. Rather than try to summarize all this research I have enclosed research papers and reports which were completed with the hnding provided by the grant. These papers and reports are listed below:

  16. Adaptive line enhancers for fast acquisition

    NASA Technical Reports Server (NTRS)

    Yeh, H.-G.; Nguyen, T. M.

    1994-01-01

    Three adaptive line enhancer (ALE) algorithms and architectures - namely, conventional ALE, ALE with double filtering, and ALE with coherent accumulation - are investigated for fast carrier acquisition in the time domain. The advantages of these algorithms are their simplicity, flexibility, robustness, and applicability to general situations including the Earth-to-space uplink carrier acquisition and tracking of the spacecraft. In the acquisition mode, these algorithms act as bandpass filters; hence, the carrier-to-noise ratio (CNR) is improved for fast acquisition. In the tracking mode, these algorithms simply act as lowpass filters to improve signal-to-noise ratio; hence, better tracking performance is obtained. It is not necessary to have a priori knowledge of the received signal parameters, such as CNR, Doppler, and carrier sweeping rate. The implementation of these algorithms is in the time domain (as opposed to the frequency domain, such as the fast Fourier transform (FFT)). The carrier frequency estimation can be updated in real time at each time sample (as opposed to the batch processing of the FFT). The carrier frequency to be acquired can be time varying, and the noise can be non-Gaussian, nonstationary, and colored.

  17. Neuroimaging and Research into Second Language Acquisition

    ERIC Educational Resources Information Center

    Sabourin, Laura

    2009-01-01

    Neuroimaging techniques are becoming not only more and more sophisticated but are also coming to be increasingly accessible to researchers. One thing that one should take note of is the potential of neuroimaging research within second language acquisition (SLA) to contribute to issues pertaining to the plasticity of the adult brain and to general…

  18. Discourse and the acquisition of grammatical morphemes.

    PubMed

    Farrar, M J

    1990-10-01

    Adult recasts of child utterances have been shown to be related in a general way to the child's acquisition of syntactic structures. The current study had two aims. The first aim was to determine which feature(s) of recasts (i.e. reformulation, expansion, topic continuation, or reply) was responsible for facilitating language acquisition by comparing them to other maternal discourse models that were systematically defined by these properties. The second aim was to investigate this relation more specifically by relating adult discourse models of specific grammatical morphemes to the child's acquisition of those same morphemes. Again, recasts were of particular interest. Twelve mother-child dyads were videorecorded during one hour of naturalistic interaction when the children were 1; 10 and 2; 4. Results indicated that maternal recasts of specific morphemes were related to the acquisition of those same grammatical morphemes during certain developmental periods, whereas other grammatical morphemes were facilitated by expansions and topic continuations. These results are discussed in terms of the processes responsible for these effects.

  19. Motor Acquisition Rate in Brazilian Infants

    ERIC Educational Resources Information Center

    Lopes, Virlaine Bardella; de Lima, Carolina Daniel; Tudella, Eloisa

    2009-01-01

    This study used the Alberta Infant Motor Scale (AIMS) with the aim of characterizing motor acquisition rate in 70 healthy 0-6-month-old Brazilian infants, as well as comparing both emergence (initial age) and establishment (final age) of each skill between the study sample and the AIMS normative data. New motor skills were continuously acquired…

  20. Microprocessor aided data acquisition at VEDAS

    SciTech Connect

    Ziem, P.; Drescher, B.; Kapper, K.; Kowallik, R.

    1985-08-01

    Three microprocessor systems have been developed to support data acquisition in nuclear physics multiparameter experiments. A bit-slice processor accumulates up to 256 1-dim spectra and 16 2-dim spectra. A microprocessor, based on the AM 29116 ALU, performs a fast consistency check on the coincidence data. A VME-Bus double-processor displays a colored scatterplot.