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Sample records for act caa requires

  1. Many new CAA requirements, deadlines scheduled during next five years

    SciTech Connect

    Iwanchuk, R. )

    1993-06-01

    Since the CAA Amendments were signed into law, EPA's rulemaking process has been underway, delineating specific compliance regulations. Many of the legislation's requirements and deadlines will be finalized over the next five years. The following list summarizes upcoming regulations and anticipated compliance deadlines. Title I applies to VOC and NOx controls in ozone non-attainment areas. Title III contains the Hazardous Organic National Emission Standard for Hazardous Air Pollutants. Title V consists of the operating permit rule. Title VII applies to the enhanced monitoring rule. The rule will require major sources to enhance monitoring systems to determine whether compliance is continuous or intermittent.

  2. A historical overview of the development of manganese (Mn) pharmacokinetic data under Section 211(b) of the Clean Air Act (CAA)

    EPA Science Inventory

    Abstract for Manganese 2016A historical overview of the development of manganese (Mn) pharmacokinetic data under Section 211(b) of the Clean Air Act (CAA)William K BoyesBackground. In the 1990’s, the use of methylcyclopentadienyl manganese tricarbonyl (MMT) as an octane-enh...

  3. 2 CFR 1532.1120 - What is the purpose of CAA or CWA disqualification?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... and Reinstatement Under the Clean Air Act and Clean Water Act § 1532.1120 What is the purpose of CAA or CWA disqualification? As provided for in Executive Order 11738 (3 CFR, 1973 Comp., p. 799),...

  4. 2 CFR 1532.1120 - What is the purpose of CAA or CWA disqualification?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... and Reinstatement Under the Clean Air Act and Clean Water Act § 1532.1120 What is the purpose of CAA or CWA disqualification? As provided for in Executive Order 11738 (3 CFR, 1973 Comp., p. 799),...

  5. 2 CFR 1532.1120 - What is the purpose of CAA or CWA disqualification?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... and Reinstatement Under the Clean Air Act and Clean Water Act § 1532.1120 What is the purpose of CAA or CWA disqualification? As provided for in Executive Order 11738 (3 CFR, 1973 Comp., p. 799),...

  6. 2 CFR 1532.1120 - What is the purpose of CAA or CWA disqualification?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... and Reinstatement Under the Clean Air Act and Clean Water Act § 1532.1120 What is the purpose of CAA or CWA disqualification? As provided for in Executive Order 11738 (3 CFR, 1973 Comp., p. 799),...

  7. Beta test results for the CAA mini-SAM system

    SciTech Connect

    Johnson, R.C.; Monagle, M.

    1997-04-01

    The mission of the Chemical Analysis Automation (CAA) Program is to automate methods for chemical analysis of environmental samples. To accomplish this mission, the CAA team has developed automated laboratory systems based on a plug-and-work strategy for integrating components. Realizing that standardization is the key to implementing this strategy, CAA has developed, demonstrated, and encouraged commercialization of standards for laboratory automation. While the CAA mission is driven by the analyses in support of the extensive remediation programs of the Departments of Energy and Defense, it also impacts any industry that depends upon high volumes of repetitive chemical analysis. A Standard Analysis Method (SAM) is any collection of hardware and software used to automate part or all of a method. The method automated for the Mini-SAM testing is EPA Method 3550, which outlines semivolatiles extraction by sonication. The list of semivolatiles includes the polychlorinated biphenyl (PCB) analytes of interest. The basic building block of a SAM is the Standard Laboratory Module (SLM). For the Mini-SAM test an automated sonication SLM and an automated concentration SLM were configured to perform the extraction and concentration processes. The Mini-SAM differs from the Full-SAM in that a fully automated delivery of materials, samples, and extracts is not required. The intent of the Beta Test of the Mini-SAM was threefold. Firstly, the Mini-SAM Beta Test met a milestone mandated by the Department of Energy in the course of the program effort. Secondly, the CAA Program secured an independent assessment of the equipment and its capabilities from Assagai Analytical Laboratory. Lastly, the Program captured real-world sample data. The independent assessment, coupled with CAA observation of equipment performance, was used to determine strengths and weaknesses of the Mini-SAM and to compile possible modifications for CAA engineers to address.

  8. CAA for Jet Noise Physics

    NASA Technical Reports Server (NTRS)

    Mankbadi, Reda

    2001-01-01

    Dr. Mankbadi summarized recent CAA results. Examples of the effect of various boundary condition schemes on the computed acoustic field, for a point source in a uniform flow, were shown. Solutions showing the impact of inflow excitations on the result were also shown. Results from a large eddy simulation, using a fourth-order MacCormack scheme with a Smagorinsky sub-grid turbulence model, were shown for a Mach 2.1 unheated jet. The results showed that the results were free from spurious modes. Results were shown for a Mach 1.4 jet using LES in the near field and the Kirchhoff method for the far field. Predicted flow field characteristics were shown to be in good agreement with data and predicted far field directivities were shown to be in qualitative agree with experimental measurements.

  9. Preparing the CAA Title V operating permit application

    SciTech Connect

    Wyles, T.R. )

    1994-01-01

    The CAA amendments contain 11 new and amended titles, including enhanced non-attainment area provisions, additional conditions for controlling hazardous air pollutants, expanded monitoring and record keeping requirements, and increased enforcement authority. The cornerstone of the regulation is the operating permits program (Title V). In the past, permits have been issued to construct or modify sources, and some sources have been permitted in states with operating permit programs. Such programs will remain in effect. However, under the new CAA, most emissions sources will be required to have an operating permit. Title V's permit provision initially affects about 34,000 major facilities and may affect another 350,000 smaller sources in the future. The amendments also increase the number of regulated pollutants from 21 to about 200. Operating permits limit emissions from manufacturing operations, and place further restrictions on raw materials and products.

  10. Cluster CAA Module for PaPCo

    NASA Astrophysics Data System (ADS)

    Faden, J.; Åsnes, A.; Friedel, R.; Taylor, M.; McCaffrey, S.; Perry, C.; Goldstein, M. L.

    A PaPCo module for visualization of data from the CAA has been developed. This module retrieves data from the CAA web interface, and allows for discovery and plotting of new datasets. PaPCo is modular, open source IDL software that uses plug-in modules to bring new datasets on to a stack of time series plots (www.papco.org). PaPCo includes modules for plotting data from Cluster/PEACE and Cluster/RAPID, CDA Web data which includes Cluster Prime Parameters, and various modules from CRRES, POLAR, GPS, and many other spacecraft. The Cluster CAA module is presented, as well as a brief description of PaPCo's use and installation procedure.

  11. 76 FR 22095 - Clean Air Act: Opportunity To Comment, Activities Required by Federal Facilities Compliance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-20

    ... companion Consent Agreement and Final Order (CAFO), Docket No. CAA-04-2010-1528(b), that TVA failed to... perform substantially the same relief as required by the Compliance Agreement. Neither the CAFO nor the... emissions of various air pollutants from units at the plants identified above. The CAFO assesses a...

  12. Long-acting methods require special care.

    PubMed

    Blaney, C L

    1994-08-01

    Long-acting contraceptive methods including IUDs, implants, and sterilization are among the most effective and convenient contraceptive methods, requiring little or no effort on the part of the user once provided by a trained healthcare provider. Some women, however, oppose the development and use of provider-dependent contraceptive methods due to the potential for method misuse. These methods, for example, could be provided without women's fully informed choice, access to removal could be blocked, or the method could be provided to an inappropriate client. Making a contraceptive method unavailable because of potential abuse instead restricts women's reproductive choices. After all, abuse generally comes from the legal or delivery system, not from the method itself. Efforts should be made to satisfy users with standard norms for performance and without targets for specific methods. Good service delivery along with revised approaches to contraceptive introduction and program evaluation can help prevent inappropriate method use and ensure that women receive adequate information and counseling to help them make reproductive choices without undue influence. The author discusses Norplant delivery, providing IUDs, offering sterilization, and improving access.

  13. 49 CFR 1105.9 - Coastal Zone Management Act requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Coastal Zone Management Act requirements. 1105.9... ENVIRONMENTAL LAWS § 1105.9 Coastal Zone Management Act requirements. (a) If the proposed action affects land or water uses within a State coastal zone designated pursuant to the Coastal Zone Management Act (16...

  14. Plainer Legal Language: Definitions and Requirements in Acts.

    ERIC Educational Resources Information Center

    Jordan, Michael P.

    1994-01-01

    Explores some of the stylistic complexities of definitions and requirements in a Canadian provincial act. Generates and justifies 15 recommendations for creating a plainer legal language in acts. (SR)

  15. 7 CFR 1948.65 - Relocation Act requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 13 2011-01-01 2009-01-01 true Relocation Act requirements. 1948.65 Section 1948.65...) PROGRAM REGULATIONS (CONTINUED) RURAL DEVELOPMENT Section 601 Energy Impacted Area Development Assistance Program § 1948.65 Relocation Act requirements. The policies and regulations contained in title 7,...

  16. 7 CFR 1948.65 - Relocation Act requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 13 2014-01-01 2013-01-01 true Relocation Act requirements. 1948.65 Section 1948.65...) PROGRAM REGULATIONS (CONTINUED) RURAL DEVELOPMENT Section 601 Energy Impacted Area Development Assistance Program § 1948.65 Relocation Act requirements. The policies and regulations contained in title 7,...

  17. 3 CFR - Combating Noncompliance With Recovery Act Reporting Requirements

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 3 The President 1 2011-01-01 2011-01-01 false Combating Noncompliance With Recovery Act Reporting Requirements Presidential Documents Other Presidential Documents Memorandum of April 6, 2010 Combating Noncompliance With Recovery Act Reporting Requirements Memorandum for the Heads of Executive Departments and Agencies My Administration...

  18. Streamlining CAA compliance plans yields added benefits

    SciTech Connect

    Miller, D.A. )

    1993-02-01

    A common approach to compliance with air emissions standards at some facilities consists of correcting deficiencies noted by regulators during their annual or semi-annual visits without developing long-term compliance plans. Many times, plant officials do not know which regulations apply to their sources. Industry no longer can afford to depend on such hit-or-miss compliance strategies. Under the CAA Amendments, EPA is empowerd to issue field citations of $5,000 per day for each violation, and monetary penalties can reach millions of dollars and be accompanied by prison sentences up to 15 years. Developing a plant-wide emissions compliance plan is one of the best ways to minimize future compliance liabilities. Data collected for such plans typically are stored in a computerized database, which also can be used in other compliance activities.

  19. 25 CFR 273.54 - Privacy Act requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... system of records without prior approval of the Department of Interior and the Office of Management and... Privacy Act requirements. (a) When a contractor operates a system of records to accomplish a Bureau function, the contractor shall comply with subpart D of 43 CFR part 2 which implements the Privacy Act (5...

  20. 25 CFR 273.54 - Privacy Act requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... system of records without prior approval of the Department of Interior and the Office of Management and... Privacy Act requirements. (a) When a contractor operates a system of records to accomplish a Bureau function, the contractor shall comply with subpart D of 43 CFR part 2 which implements the Privacy Act (5...

  1. 25 CFR 273.54 - Privacy Act requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... system of records without prior approval of the Department of Interior and the Office of Management and... Privacy Act requirements. (a) When a contractor operates a system of records to accomplish a Bureau function, the contractor shall comply with subpart D of 43 CFR part 2 which implements the Privacy Act (5...

  2. 25 CFR 273.54 - Privacy Act requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... system of records without prior approval of the Department of Interior and the Office of Management and... Privacy Act requirements. (a) When a contractor operates a system of records to accomplish a Bureau function, the contractor shall comply with subpart D of 43 CFR part 2 which implements the Privacy Act (5...

  3. 25 CFR 273.54 - Privacy Act requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... function, the contractor shall comply with subpart D of 43 CFR part 2 which implements the Privacy Act (5 U.... 43 CFR 2.56 lists exceptions to this procedure. (4) To establish a procedure to account for access... 25 Indians 1 2010-04-01 2010-04-01 false Privacy Act requirements. 273.54 Section 273.54...

  4. 2 CFR 1532.1110 - How will a CAA or CWA conviction affect my eligibility to participate in Federal contracts...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the Clean Air Act and Clean Water Act § 1532.1110 How will a CAA or CWA conviction affect my... debarment and suspension system (i.e. covered transactions under subpart A through I of 2 CFR part 180, or prohibited awards under 48 CFR part 9, subpart 9.4), if you: (a) Will perform any part of the transaction...

  5. 2 CFR 1532.1110 - How will a CAA or CWA conviction affect my eligibility to participate in Federal contracts...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the Clean Air Act and Clean Water Act § 1532.1110 How will a CAA or CWA conviction affect my... debarment and suspension system (i.e. covered transactions under subpart A through I of 2 CFR part 180, or prohibited awards under 48 CFR part 9, subpart 9.4), if you: (a) Will perform any part of the transaction...

  6. 2 CFR 1532.1110 - How will a CAA or CWA conviction affect my eligibility to participate in Federal contracts...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... the Clean Air Act and Clean Water Act § 1532.1110 How will a CAA or CWA conviction affect my... debarment and suspension system (i.e. covered transactions under subpart A through I of 2 CFR part 180, or prohibited awards under 48 CFR part 9, subpart 9.4), if you: (a) Will perform any part of the transaction...

  7. 2 CFR 1532.1130 - How does disqualification under the CAA or CWA differ from a Federal discretionary suspension or...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Clean Air Act and Clean Water Act § 1532.1130 How does disqualification under the CAA or CWA differ from... 2 CFR part 180 or under 48 CFR part 9, subpart 9.4, are exclusions imposed at the discretion of... I of 2 CFR part 180, or under 48 CFR part 9, subpart 9.4....

  8. 2 CFR 1532.1130 - How does disqualification under the CAA or CWA differ from a Federal discretionary suspension or...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Clean Air Act and Clean Water Act § 1532.1130 How does disqualification under the CAA or CWA differ from... 2 CFR part 180 or under 48 CFR part 9, subpart 9.4, are exclusions imposed at the discretion of... I of 2 CFR part 180, or under 48 CFR part 9, subpart 9.4....

  9. 2 CFR 1532.1110 - How will a CAA or CWA conviction affect my eligibility to participate in Federal contracts...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... the Clean Air Act and Clean Water Act § 1532.1110 How will a CAA or CWA conviction affect my... debarment and suspension system (i.e. covered transactions under subpart A through I of 2 CFR part 180, or prohibited awards under 48 CFR part 9, subpart 9.4), if you: (a) Will perform any part of the transaction...

  10. 2 CFR 1532.1130 - How does disqualification under the CAA or CWA differ from a Federal discretionary suspension or...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Clean Air Act and Clean Water Act § 1532.1130 How does disqualification under the CAA or CWA differ from... 2 CFR part 180 or under 48 CFR part 9, subpart 9.4, are exclusions imposed at the discretion of... I of 2 CFR part 180, or under 48 CFR part 9, subpart 9.4....

  11. 2 CFR 1532.1130 - How does disqualification under the CAA or CWA differ from a Federal discretionary suspension or...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Clean Air Act and Clean Water Act § 1532.1130 How does disqualification under the CAA or CWA differ from... 2 CFR part 180 or under 48 CFR part 9, subpart 9.4, are exclusions imposed at the discretion of... I of 2 CFR part 180, or under 48 CFR part 9, subpart 9.4....

  12. 40 CFR 51.126 - Determination of widespread use of ORVR and waiver of CAA section 182(b)(3) Stage II gasoline...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... and waiver of CAA section 182(b)(3) Stage II gasoline vapor recovery requirements. 51.126 Section 51... FOR PREPARATION, ADOPTION, AND SUBMITTAL OF IMPLEMENTATION PLANS Control Strategy § 51.126 Determination of widespread use of ORVR and waiver of CAA section 182(b)(3) Stage II gasoline vapor...

  13. 40 CFR 51.126 - Determination of widespread use of ORVR and waiver of CAA section 182(b)(3) Stage II gasoline...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 2 2012-07-01 2012-07-01 false Determination of widespread use of ORVR and waiver of CAA section 182(b)(3) Stage II gasoline vapor recovery requirements. 51.126 Section 51... Determination of widespread use of ORVR and waiver of CAA section 182(b)(3) Stage II gasoline vapor...

  14. Second Computational Aeroacoustics (CAA) Workshop on Benchmark Problems

    NASA Technical Reports Server (NTRS)

    Tam, C. K. W. (Editor); Hardin, J. C. (Editor)

    1997-01-01

    The proceedings of the Second Computational Aeroacoustics (CAA) Workshop on Benchmark Problems held at Florida State University are the subject of this report. For this workshop, problems arising in typical industrial applications of CAA were chosen. Comparisons between numerical solutions and exact solutions are presented where possible.

  15. Quick Win or Slow Burn: Modelling UK HE CAA Uptake

    ERIC Educational Resources Information Center

    Warburton, Bill

    2009-01-01

    The uptake of CAA in UK higher education (HE) on a large scale lags behind the expectations of CAA specialists. A research project was undertaken with the aim of discovering and addressing the underlying reasons for this. The research was conducted according to Strauss and Corbin's (1998) prescription for grounded theory (GT) research. During…

  16. Compliance with the Clean Air Act Title VI Stratospheric Ozone Protection Program requirements at U.S. DOE Oak Ridge Reservation Facilities

    SciTech Connect

    Humphreys, M.P.; Atkins, E.M.

    1999-07-01

    The Title VI Stratospheric Ozone Protection Program of the Clean Air Act (CAA) requires promulgation of regulations to reduce and prevent damage to the earth's protective ozone layer. Regulations pursuant to Title VI of the CAA are promulgated in the Code of Federal Regulations (CFR) at Title 40 CFR, Part 822. The regulations include ambitious production phaseout schedules for ozone depleting substances (ODS) including chlorofluorocarbons (CFCs), hydrochlorofluorocarbons (HCFCs), halons, carbon tetrachloride, and methyl chloroform under 40 CFR 82, Subpart A. The regulations also include requirements for recycling and emissions reduction during the servicing of refrigeration equipment and technician certification requirements under Subpart F; provisions for servicing of motor vehicle air conditioners under Subpart B; a ban on nonessential products containing Class 1 ODS under Subpart C; restrictions on Federal procurement of ODS under Subpart D; labeling of products using ODS under Subpart E; and the Significant New Alternatives Policy Program under Subpart G. This paper will provide details of initiatives undertaken at US Department of Energy (DOE) Oak Ridge Reservation (ORR) Facilities for implementation of requirements under the Title VI Stratospheric Ozone Protection Program. The Stratospheric Ozone Protection Plans include internal DOE requirements for: (1) maintenance of ODS inventories; (2) ODS procurement practices; (3) servicing of refrigeration and air conditioning equipment; (4) required equipment modifications or replacement; (5) technician certification training; (6) labeling of products containing ODS; (7) substitution of chlorinated solvents; and (8) replacement of halon fire protection systems. The plans also require establishment of administrative control systems which assure that compliance is achieved and maintained as the regulations continue to develop and become effective.

  17. 30 CFR 552.6 - Freedom of Information Act requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) and 30 CFR part 551 (Geological and Geophysical Explorations of the Outer Continental Shelf). (b... Section 552.6 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE... contained in 43 CFR part 2 (Records and Testimony), the requirements of the Act, and the...

  18. 30 CFR 552.6 - Freedom of Information Act requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) and 30 CFR part 551 (Geological and Geophysical Explorations of the Outer Continental Shelf). (b... Section 552.6 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE... contained in 43 CFR part 2 (Records and Testimony), the requirements of the Act, and the...

  19. 30 CFR 552.6 - Freedom of Information Act requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) and 30 CFR part 551 (Geological and Geophysical Explorations of the Outer Continental Shelf). (b... Section 552.6 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE... contained in 43 CFR part 2 (Records and Testimony), the requirements of the Act, and the...

  20. 30 CFR 252.6 - Freedom of Information Act requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Section 252.6 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR... contained in 43 CFR part 2 (Records and Testimony), the requirements of the Act, and the regulations contained in 30 CFR parts 250 and 550 (Oil and Gas and Sulphur Operations in the Outer Continental...

  1. 30 CFR 252.6 - Freedom of Information Act requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Section 252.6 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR... contained in 43 CFR part 2 (Records and Testimony), the requirements of the Act, and the regulations contained in 30 CFR parts 250 and 550 (Oil and Gas and Sulphur Operations in the Outer Continental...

  2. 30 CFR 252.6 - Freedom of Information Act requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Section 252.6 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR... contained in 43 CFR part 2 (Records and Testimony), the requirements of the Act, and the regulations contained in 30 CFR parts 250 and 550 (Oil and Gas and Sulphur Operations in the Outer Continental...

  3. Implementation of the Clean Air Act, Title III, Section 112(r) Prevention of Accidental Release Rule requirements at U.S. DOE Oak Ridge Reservation facilities

    SciTech Connect

    Humphreys, M.P.; Fellers, H.L.

    1997-12-31

    Title III, Section 112(r) of the Clean Air Act (CAA) Amendments of 1990 requires the Environmental Protection Agency (EPA) to promulgate regulations to prevent accidental releases of regulated substances and to reduce the severity of those releases that do occur. The final EPA rule for Risk Management Programs under Section 112(r)(7) of the CAA, promulgated June 20, 1996, applies to all stationary sources with processes that contain more than a threshold quantity of any of 139 regulated substances listed under 40 CFR 68.130. All affected sources will be required to prepare a risk management plan which must be submitted to EPA and be made available to state and local governments and to the public. This paper will provide details of initiatives underway at US Department of Energy (DOE) Oak Ridge Reservation (ORR) Facilities for implementation of the Prevention of Accidental Release Rule. The ORR encompasses three DOE Facilities: the Y-12 Plant, Oak Ridge National Laboratory (ORNL), and the K-25 Site. The Y-12 Plant manufactures component parts for the national nuclear weapons program; the ORNL is responsible for research and development activities including nuclear engineering, engineering technologies, and the environmental sciences; and the K-25 Site conducts a variety of research and development activities and is the home of a mixed waste incinerator. ORR activities underway and soon to be undertaken toward implementation of the Prevention of Accidental Release Rule include: compilation of inventories of regulated substances at all processes at each of the three ORR Facilities for determination of affected processes and facilities; plans for inventory reduction to levels below threshold quantities, where necessary and feasible; determination of the overlap of processes subject to the OSHA PSM Standard and determination of parallel requirements; preparation of Risk Management Plans and Programs for affected processes and facilities including detailed requirements

  4. Implementation of the Clean Air Act, Title V operating permit program requirements for the U.S. DOE Oak Ridge Reservation facilities

    SciTech Connect

    Humphreys, M.P.

    1998-12-31

    Title V of the Clean Air Act (CAA) establishes a new permit program requiring major sources and sources subject to Title III (Hazardous Air Pollutants) to obtain a state operating permit. Historically, most states have issued operating permits for individual emission units. Under the Title V permit program, a single permit will be issued for all of the emission units at the facility much like the current National Pollutant Discharge Elimination System (NPDES) permit program. The permit will specify all reporting, monitoring, and record-keeping requirements for the facility. Sources required to obtain permits include (a) major sources that emit 100 tons per year or more of any criteria air contaminant, (b) any source subject to the HAP provisions of Title III, (c) any source subject to the acid rain provisions of Title IV, (d) any source subject to New Source Performance Standards, and (e) any source subject to new source review under the nonattainment or Prevention of Significant Deterioration provisions. The State of Tennessee Title V Operating Permit Program was approved by EPA on August 28, 1996. This paper will provide details of initiatives underway at US Department of Energy (DOE) Oak Ridge Reservation (ORR) Facilities for implementation of requirements under the Title V Operating Permit Program. The ORR encompasses three DOE Facilities: the Y-12 Plant, Oak Ridge National Laboratory (ORNL), and the East Tennessee Technology Park (ETTP). The Y-12 Plant manufactures component parts for the national nuclear weapons program; the ORNL is responsible for research and development activities including nuclear engineering, engineering technologies, and the environmental sciences; and the ETTP conducts a variety of research and development activities and is the home of a mixed waste incinerator. Each of the three DOE Facilities is considered a major source under Title V of the CAA.

  5. Benchmark Solutions for Computational Aeroacoustics (CAA) Code Validation

    NASA Technical Reports Server (NTRS)

    Scott, James R.

    2004-01-01

    NASA has conducted a series of Computational Aeroacoustics (CAA) Workshops on Benchmark Problems to develop a set of realistic CAA problems that can be used for code validation. In the Third (1999) and Fourth (2003) Workshops, the single airfoil gust response problem, with real geometry effects, was included as one of the benchmark problems. Respondents were asked to calculate the airfoil RMS pressure and far-field acoustic intensity for different airfoil geometries and a wide range of gust frequencies. This paper presents the validated that have been obtained to the benchmark problem, and in addition, compares them with classical flat plate results. It is seen that airfoil geometry has a strong effect on the airfoil unsteady pressure, and a significant effect on the far-field acoustic intensity. Those parts of the benchmark problem that have not yet been adequately solved are identified and presented as a challenge to the CAA research community.

  6. 78 FR 29306 - Approval and Promulgation of Implementation Plans; Florida; Infrastructure Requirements for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-20

    ... infrastructure requirements of the Clean Air Act (CAA or Act) for the 2008 8-hour ozone national ambient air... entitled, ``Scope of Infrastructure SIPs.'' See 77 FR 66927. IV. What is EPA's analysis of how Florida..., 2012. See 77 FR 35862. Thus, EPA has preliminarily determined that the infrastructure SIP submission...

  7. Fourth Computational Aeroacoustics (CAA) Workshop on Benchmark Problems

    NASA Technical Reports Server (NTRS)

    Dahl, Milo D. (Editor)

    2004-01-01

    This publication contains the proceedings of the Fourth Computational Aeroacoustics (CAA) Workshop on Benchmark Problems. In this workshop, as in previous workshops, the problems were devised to gauge the technological advancement of computational techniques to calculate all aspects of sound generation and propagation in air directly from the fundamental governing equations. A variety of benchmark problems have been previously solved ranging from simple geometries with idealized acoustic conditions to test the accuracy and effectiveness of computational algorithms and numerical boundary conditions; to sound radiation from a duct; to gust interaction with a cascade of airfoils; to the sound generated by a separating, turbulent viscous flow. By solving these and similar problems, workshop participants have shown the technical progress from the basic challenges to accurate CAA calculations to the solution of CAA problems of increasing complexity and difficulty. The fourth CAA workshop emphasized the application of CAA methods to the solution of realistic problems. The workshop was held at the Ohio Aerospace Institute in Cleveland, Ohio, on October 20 to 22, 2003. At that time, workshop participants presented their solutions to problems in one or more of five categories. Their solutions are presented in this proceedings along with the comparisons of their solutions to the benchmark solutions or experimental data. The five categories for the benchmark problems were as follows: Category 1:Basic Methods. The numerical computation of sound is affected by, among other issues, the choice of grid used and by the boundary conditions. Category 2:Complex Geometry. The ability to compute the sound in the presence of complex geometric surfaces is important in practical applications of CAA. Category 3:Sound Generation by Interacting With a Gust. The practical application of CAA for computing noise generated by turbomachinery involves the modeling of the noise source mechanism as a

  8. 78 FR 58186 - Approval and Promulgation of State Implementation Plan Revisions; Infrastructure Requirements for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-23

    ... for infrastructure purposes, we will then evaluate Colorado's infrastructure submission for the 2012... Implementation Plan Revisions; Infrastructure Requirements for the 1997 and 2006 PM 2.5 National Ambient Air... to demonstrate that the SIP meets the infrastructure requirements of the Clean Air Act (CAA) for...

  9. 77 FR 64425 - Approval and Promulgation of Implementation Plans; Alaska: Infrastructure Requirements for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ... from 0.12 parts per million (ppm) to 0.08 ppm (62 FR 38856). The CAA requires SIPs meeting the... State of Alaska to act on the State's infrastructure SIP for the 1997 8-hour ozone NAAQS (77 FR 16785... requirements. EPA provided a 30-day review and comment period on the NPR published March 22, 2012 (77 FR...

  10. 76 FR 55905 - Agency Information Collection Activities; Proposed Collection; Comment Request; Requirements for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-09

    ... particular, EPA is requesting comments from very small businesses (those that employ less than 25) or.... 1658.04 expires on January 31, 2010. An Agency may not conduct or sponsor, and a person is not required.... Abstract: Section 112(g)(2)(B) of the Clean Air Act as amended in 1990 (CAA) requires that...

  11. 7 CFR 3575.40 - Equal opportunity and Fair Housing Act requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Federal Reserve Board Regulation, 12 CFR part 202.) (b) Fair Housing Act. Certain housing-related projects... 7 Agriculture 15 2011-01-01 2011-01-01 false Equal opportunity and Fair Housing Act requirements... opportunity and Fair Housing Act requirements. (a) Equal Credit Opportunity Act. The lender will comply...

  12. Third Computational Aeroacoustics (CAA) Workshop on Benchmark Problems

    NASA Technical Reports Server (NTRS)

    Dahl, Milo D. (Editor)

    2000-01-01

    The proceedings of the Third Computational Aeroacoustics (CAA) Workshop on Benchmark Problems cosponsored by the Ohio Aerospace Institute and the NASA Glenn Research Center are the subject of this report. Fan noise was the chosen theme for this workshop with representative problems encompassing four of the six benchmark problem categories. The other two categories were related to jet noise and cavity noise. For the first time in this series of workshops, the computational results for the cavity noise problem were compared to experimental data. All the other problems had exact solutions, which are included in this report. The Workshop included a panel discussion by representatives of industry. The participants gave their views on the status of applying computational aeroacoustics to solve practical industry related problems and what issues need to be addressed to make CAA a robust design tool.

  13. Hybrid CFD/CAA Modeling for Liftoff Acoustic Predictions

    NASA Technical Reports Server (NTRS)

    Strutzenberg, Louise L.; Liever, Peter A.

    2011-01-01

    This paper presents development efforts at the NASA Marshall Space flight Center to establish a hybrid Computational Fluid Dynamics and Computational Aero-Acoustics (CFD/CAA) simulation system for launch vehicle liftoff acoustics environment analysis. Acoustic prediction engineering tools based on empirical jet acoustic strength and directivity models or scaled historical measurements are of limited value in efforts to proactively design and optimize launch vehicles and launch facility configurations for liftoff acoustics. CFD based modeling approaches are now able to capture the important details of vehicle specific plume flow environment, identifY the noise generation sources, and allow assessment of the influence of launch pad geometric details and sound mitigation measures such as water injection. However, CFD methodologies are numerically too dissipative to accurately capture the propagation of the acoustic waves in the large CFD models. The hybrid CFD/CAA approach combines the high-fidelity CFD analysis capable of identifYing the acoustic sources with a fast and efficient Boundary Element Method (BEM) that accurately propagates the acoustic field from the source locations. The BEM approach was chosen for its ability to properly account for reflections and scattering of acoustic waves from launch pad structures. The paper will present an overview of the technology components of the CFD/CAA framework and discuss plans for demonstration and validation against test data.

  14. NASA's Principal Center for Review of Clean Air Act Regulations

    NASA Technical Reports Server (NTRS)

    Clark-Ingram, Marceia

    2003-01-01

    Marshall Space Flight Center (MSFC) was selected as the Principal Center for review of Clean Air Act (CAA) regulations. The CAA Principal Center is tasked to: 1) Provide centralized support to NASA/HDQ Code JE for the management and leadership of NASA's CAA regulation review process; 2) Identify potential impact from proposed CAA regulations to NASA program hardware and supporting facilities. The Shuttle Environmental Assurance Initiative, one of the responsibilities of the NASA CAA Working Group (WG), is described in part of this viewgraph presentation.

  15. The Americans with Disabilities Act and Family and Medical Leave Act: Legal Requirements, Negotiations and Policy Considerations.

    ERIC Educational Resources Information Center

    Juengart, Laurie S.

    The Americans with Disabilities Act (ADA) and Family and Medical Leave Act (FMLA) are two major pieces of social legislation that impact private and public employers, including school districts. Public school employers must have thorough awareness of the legal requirements of both laws and must analyze the ways in which those requirements…

  16. Cluster Ion Spectrometry (CIS) Data Archiving in the CAA

    NASA Astrophysics Data System (ADS)

    Dandouras, I. S.; Barthe, A.; Penou, E.; Brunato, S.; Reme, H.; Kistler, L. M.; Blagau, A.; Facsko, G.; Kronberg, E.; Laakso, H. E.

    2009-12-01

    The Cluster Active Archive (CAA) aims at preserving the four Cluster spacecraft data, so that they are usable in the long-term by the scientific community as well as by the instrument team PIs and Co-Is. This implies that the data are filed together with the descriptive and documentary elements making it possible to select and interpret them. The CIS (Cluster Ion Spectrometry) experiment is a comprehensive ionic plasma spectrometry package onboard the four Cluster spacecraft, capable of obtaining full three-dimensional ion distributions (about 0 to 40 keV/e) with a time resolution of one spacecraft spin (4 sec) and with mass-per-charge composition determination. The CIS package consists of two different instruments, a Hot Ion Analyser (HIA) and a time-of-flight ion Composition Distribution Function (CODIF) analyser. For the archival of the CIS data a multi-level approach has been adopted. The CAA archival includes processed raw data (Level 1 data), moments of the ion distribution functions (Level 2 data), and calibrated high-resolution data in a variety of physical units (Level 3 data). The latter are 3-D ion distribution functions and 2-D pitch-angle distributions. In addition, a software package has been developed to allow the CAA user to interactively calculate partial or total moments of the ion distributions. Instrument cross-calibration has been an important activity in preparing the data for archival. The CIS data archive includes also experiment documentation, graphical products for browsing through the data, and data caveats. In addition, data quality indexes are under preparation, to help the user. Given the complexity of an ion spectrometer, and the variety of its operational modes, each one being optimised for a different magnetospheric region or measurement objective, consultation of the data caveats by the end user will always be a necessary step in the data analysis.

  17. 40 CFR 52.1586 - Section 110(a)(2) infrastructure requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) New Jersey § 52.1586... certified that the State has satisfied the Clean Air Act (CAA) infrastructure requirements of section 110(a... addressed by 40 CFR 52.1603 which has been delegated to New Jersey to implement. (3) Conditional...

  18. 40 CFR 52.1586 - Section 110(a)(2) infrastructure requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) New Jersey § 52.1586... certified that the State has satisfied the Clean Air Act (CAA) infrastructure requirements of section 110(a... addressed by 40 CFR 52.1603 which has been delegated to New Jersey to implement. (3) Conditional...

  19. NASA Principal Center for Review of Clean Air Act Regulations

    NASA Technical Reports Server (NTRS)

    Clark-Ingram, Marceia; Munafo, Paul M. (Technical Monitor)

    2002-01-01

    The Clean Air Act (CAA) regulations have greatly impacted materials and processes utilized in the manufacture of aerospace hardware. Code JE/ NASA's Environmental Management Division at NASA Headquarters recognized the need for a formal, Agency-wide review process of CAA regulations. Marshall Space Flight Center (MSFC) was selected as the 'Principal Center for Review of Clean Air Act Regulations'. This presentation describes the centralized support provided by MSFC for the management and leadership of NASA's CAA regulation review process.

  20. CAA amendments` Title III could mean `future shock` to U.S. industry competitiveness

    SciTech Connect

    Rocco, V.A.

    1995-06-01

    While the regulated community awaits congressional action that could alter the government`s role in environmental protection and enforcement, the stipulations of existing regulations continue to unfold. Attention is focused on upcoming permitting deadlines imposed by the Clean Air Act Amendments of 1990, due by November for most facilities, and on products and strategies for air pollution control. Unless Congress adopts the unlikely strategy of rolling back all environmental regulations, the obligations on industry imposed by the CAA Amendments will continue to set forth a formidable compliance task. The Amendments ``created a complex maze of new and dramatically altered regulatory programs that will influence how US industry must operate well into the next century.`` This article provides an overview and guidelines for complying with the new rules.

  1. Antioxidant activity of puha (Sonchus oleraceus L.) as assessed by the cellular antioxidant activity (CAA) assay.

    PubMed

    McDowell, Arlene; Thompson, Scott; Stark, Mirjam; Ou, Zong-Quan; Gould, Kevin S

    2011-12-01

    There is considerable interest in antioxidant dietary components that can be protective against degenerative diseases in humans. Puha (Sonchus oleraceus L.) is a rich source of polyphenols, and exhibits strong antioxidant activity as measured by the 2,2-diphenylpicrylhydrazyl (DPPH) assay. However, the potential of puha to protect against degenerative diseases requires that low molecular weight antioxidants (LMWA) are absorbed by, and active in, human cells. The cellular antioxidant activity (CAA) assay was used to investigate the antioxidant activity of puha leaf extracts. Preparation methods of freezing and freeze-drying reduced the total polyphenolic content compared with fresh puha, but did not affect the LMWA potential as determined by the DPPH assay. The IC(50) values were 0.012 ± 0.003 mg/mL and 0.010 ± 0.005 mg/mL for freeze-dried and fresh puha leaves, respectively. Using the CAA assay, it was shown that LMWAs from foliar extracts of puha were effectively absorbed into HepG2 cells, and exerted antioxidant activity at levels comparable to those of extracts from blueberry fruits, the much-touted antioxidant superfood. Methylene blue staining of HepG2 cells indicated that puha extracts were not cytotoxic at concentrations below 100 mg DW/mL. The data indicate the potential of puha as a nutraceutical supplement for human health.

  2. 47 CFR 80.163 - Operator requirements of the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Operator requirements of the Bridge-to-Bridge... Requirements § 80.163 Operator requirements of the Bridge-to-Bridge Act. Each ship subject to the Bridge-to-Bridge Act must have on board a radio operator who holds a restricted radiotelephone operator permit...

  3. 47 CFR 80.163 - Operator requirements of the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Operator requirements of the Bridge-to-Bridge... Requirements § 80.163 Operator requirements of the Bridge-to-Bridge Act. Each ship subject to the Bridge-to-Bridge Act must have on board a radio operator who holds a restricted radiotelephone operator permit...

  4. 47 CFR 80.163 - Operator requirements of the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Operator requirements of the Bridge-to-Bridge... Requirements § 80.163 Operator requirements of the Bridge-to-Bridge Act. Each ship subject to the Bridge-to-Bridge Act must have on board a radio operator who holds a restricted radiotelephone operator permit...

  5. 47 CFR 80.163 - Operator requirements of the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Operator requirements of the Bridge-to-Bridge... Requirements § 80.163 Operator requirements of the Bridge-to-Bridge Act. Each ship subject to the Bridge-to-Bridge Act must have on board a radio operator who holds a restricted radiotelephone operator permit...

  6. 47 CFR 80.163 - Operator requirements of the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Operator requirements of the Bridge-to-Bridge... Requirements § 80.163 Operator requirements of the Bridge-to-Bridge Act. Each ship subject to the Bridge-to-Bridge Act must have on board a radio operator who holds a restricted radiotelephone operator permit...

  7. 47 CFR 80.305 - Watch requirements of the Communications Act and the Safety Convention.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Watch requirements of the Communications Act... (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Safety Watch Requirements and Procedures Ship Station Safety Watches § 80.305 Watch requirements of the Communications Act and the...

  8. 47 CFR 80.305 - Watch requirements of the Communications Act and the Safety Convention.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Watch requirements of the Communications Act... (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Safety Watch Requirements and Procedures Ship Station Safety Watches § 80.305 Watch requirements of the Communications Act and the...

  9. 47 CFR 80.305 - Watch requirements of the Communications Act and the Safety Convention.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Watch requirements of the Communications Act... (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Safety Watch Requirements and Procedures Ship Station Safety Watches § 80.305 Watch requirements of the Communications Act and the...

  10. 47 CFR 80.305 - Watch requirements of the Communications Act and the Safety Convention.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Watch requirements of the Communications Act... (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Safety Watch Requirements and Procedures Ship Station Safety Watches § 80.305 Watch requirements of the Communications Act and the...

  11. 47 CFR 80.309 - Watch required by the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Watch required by the Bridge-to-Bridge Act. 80... Safety Watches § 80.309 Watch required by the Bridge-to-Bridge Act. In addition to the watch requirement contained in § 80.148, all vessels subject to the Bridge-to-Bridge Act must keep a watch on the...

  12. 47 CFR 80.309 - Watch required by the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Watch required by the Bridge-to-Bridge Act. 80... Safety Watches § 80.309 Watch required by the Bridge-to-Bridge Act. In addition to the watch requirement contained in § 80.148, all vessels subject to the Bridge-to-Bridge Act must keep a watch on the...

  13. 47 CFR 80.309 - Watch required by the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Watch required by the Bridge-to-Bridge Act. 80... Safety Watches § 80.309 Watch required by the Bridge-to-Bridge Act. In addition to the watch requirement contained in § 80.148, all vessels subject to the Bridge-to-Bridge Act must keep a watch on the...

  14. 47 CFR 80.309 - Watch required by the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Watch required by the Bridge-to-Bridge Act. 80... Safety Watches § 80.309 Watch required by the Bridge-to-Bridge Act. In addition to the watch requirement contained in § 80.148, all vessels subject to the Bridge-to-Bridge Act must keep a watch on the...

  15. 47 CFR 80.309 - Watch required by the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Watch required by the Bridge-to-Bridge Act. 80... Safety Watches § 80.309 Watch required by the Bridge-to-Bridge Act. In addition to the watch requirement contained in § 80.148, all vessels subject to the Bridge-to-Bridge Act must keep a watch on the...

  16. A shunt pathway limits the CaaX processing of Hsp40 Ydj1p and regulates Ydj1p-dependent phenotypes

    PubMed Central

    Hildebrandt, Emily R; Cheng, Michael; Zhao, Peng; Kim, June H; Wells, Lance; Schmidt, Walter K

    2016-01-01

    The modifications occurring to CaaX proteins have largely been established using few reporter molecules (e.g. Ras, yeast a-factor mating pheromone). These proteins undergo three coordinated COOH-terminal events: isoprenylation of the cysteine, proteolytic removal of aaX, and COOH-terminal methylation. Here, we investigated the coupling of these modifications in the context of the yeast Ydj1p chaperone. We provide genetic, biochemical, and biophysical evidence that the Ydj1p CaaX motif is isoprenylated but not cleaved and carboxylmethylated. Moreover, we demonstrate that Ydj1p-dependent thermotolerance and Ydj1p localization are perturbed when alternative CaaX motifs are transplanted onto Ydj1p. The abnormal phenotypes revert to normal when post-isoprenylation events are genetically interrupted. Our findings indicate that proper Ydj1p function requires an isoprenylatable CaaX motif that is resistant to post-isoprenylation events. These results expand on the complexity of protein isoprenylation and highlight the impact of post-isoprenylation events in regulating the function of Ydj1p and perhaps other CaaX proteins. DOI: http://dx.doi.org/10.7554/eLife.15899.001 PMID:27525482

  17. 47 CFR 1.990 - Citizenship and filing requirements under the Communications Act of 1934.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., as amended, 15 U.S.C. 78a et seq. (Exchange Act), and corresponding Exchange Act Rule 13d-1, 17 CFR... corresponding Exchange Act Rule 13d-1, 17 CFR 240.13d-1, or a substantially comparable foreign law or regulation... 47 Telecommunication 1 2013-10-01 2013-10-01 false Citizenship and filing requirements under...

  18. 47 CFR 1.990 - Citizenship and filing requirements under the Communications Act of 1934.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., as amended, 15 U.S.C. 78a et seq. (Exchange Act), and corresponding Exchange Act Rule 13d-1, 17 CFR... corresponding Exchange Act Rule 13d-1, 17 CFR 240.13d-1, or a substantially comparable foreign law or regulation... 47 Telecommunication 1 2014-10-01 2014-10-01 false Citizenship and filing requirements under...

  19. Federal Interagency Day Care Requirements, Pursuant to Sec. 522 (D) of the Economic Opportunity Act.

    ERIC Educational Resources Information Center

    Department of Health, Education, and Welfare, Washington, DC.

    This document defines federal interagency requirements which day care programs must meet if they are receiving funds under any of the following programs: Title IV (parts A and B) of the Social Security Act; Title I, Title II, Title III (Part B), and Title V (Part B) of the Economic Opportunity Act; the Manpower Development and Training Act; and…

  20. 75 FR 75692 - Manufactured Home Construction and Safety Standards Act Reporting Requirements; Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-06

    ... URBAN DEVELOPMENT Manufactured Home Construction and Safety Standards Act Reporting Requirements; Notice.... This Notice also lists the following information: Title of Proposal: Manufactured Home Construction and Safety Standards Reporting Requirements. OMB Control Number, if applicable: 2502-0253. Description of...

  1. CAA for Jet Noise Physics: Issues and Recent Progress

    NASA Technical Reports Server (NTRS)

    Mankbadi, Reda

    2001-01-01

    Dr. Mankbadi summarized recent CAA results. Examples of the effect of various boundary condition schemes on the computed acoustic field, for a point source in a uniform flow, were shown. Solutions showing the impact of inflow excitations on the result were also shown. Results from a large eddy simulation, using a fourth-order MacCormack scheme with a Smagorinsky sub-grid turbulence model, were shown for a Mach 2.1 unheated jet. The results showed that the results were free from spurious modes. Results were shown for a Mach 1.4 jet using LES in the near field and the Kirchhoff method for the far field. Predicted flow field characteristics were shown to be in good agreement with data and predicted far field directivities were shown to be in qualitative agree with experimental measurements.

  2. 45 CFR 73.735-901 - Reporting requirement of the Ethics in Government Act of 1978.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Reporting requirement of the Ethics in Government... requirement of the Ethics in Government Act of 1978. (a) Applicability. The following employees and special... Title II of the Ethics in Government Act of 1978, Pub. L. 95-521, as amended: (1) Officers and...

  3. 45 CFR 73.735-901 - Reporting requirement of the Ethics in Government Act of 1978.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Reporting requirement of the Ethics in Government... requirement of the Ethics in Government Act of 1978. (a) Applicability. The following employees and special... Title II of the Ethics in Government Act of 1978, Pub. L. 95-521, as amended: (1) Officers and...

  4. 77 FR 13617 - Agency Information Collection Activities: Customs Modernization Act Recordkeeping Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-07

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Customs Modernization Act Recordkeeping Requirements AGENCY: U.S. Customs and Border Protection (CBP), Department of... concerning the Customs Modernization Act Recordkeeping Requirements. This request for comment is being...

  5. 45 CFR 73.735-901 - Reporting requirement of the Ethics in Government Act of 1978.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Reporting requirement of the Ethics in Government... requirement of the Ethics in Government Act of 1978. (a) Applicability. The following employees and special... Title II of the Ethics in Government Act of 1978, Pub. L. 95-521, as amended: (1) Officers and...

  6. 45 CFR 73.735-901 - Reporting requirement of the Ethics in Government Act of 1978.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Reporting requirement of the Ethics in Government... requirement of the Ethics in Government Act of 1978. (a) Applicability. The following employees and special... Title II of the Ethics in Government Act of 1978, Pub. L. 95-521, as amended: (1) Officers and...

  7. 5 CFR 1830.2 - Requirements for making Privacy Act requests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Requirements for making Privacy Act requests. 1830.2 Section 1830.2 Administrative Personnel OFFICE OF SPECIAL COUNSEL PRIVACY § 1830.2 Requirements for making Privacy Act requests. (a) How made and addressed. A request for OSC records under...

  8. 28 CFR 55.22 - Requirements of section 5 of the Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Requirements of section 5 of the Act. 55.22 Section 55.22 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) IMPLEMENTATION OF THE PROVISIONS OF THE VOTING RIGHTS ACT REGARDING LANGUAGE MINORITY GROUPS Preclearance § 55.22 Requirements...

  9. 28 CFR 55.22 - Requirements of section 5 of the Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Requirements of section 5 of the Act. 55.22 Section 55.22 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) IMPLEMENTATION OF THE PROVISIONS OF THE VOTING RIGHTS ACT REGARDING LANGUAGE MINORITY GROUPS Preclearance § 55.22 Requirements...

  10. 21 CFR 16.24 - Regulatory hearing required by the act or a regulation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... regulation. 16.24 Section 16.24 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN....24 Regulatory hearing required by the act or a regulation. (a) A regulatory hearing required by the act or a regulation under § 16.1(b) will be initiated in the same manner as other regulatory...

  11. 21 CFR 16.24 - Regulatory hearing required by the act or a regulation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... regulation. 16.24 Section 16.24 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN....24 Regulatory hearing required by the act or a regulation. (a) A regulatory hearing required by the act or a regulation under § 16.1(b) will be initiated in the same manner as other regulatory...

  12. 45 CFR 73.735-901 - Reporting requirement of the Ethics in Government Act of 1978.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Reporting requirement of the Ethics in Government Act of 1978. 73.735-901 Section 73.735-901 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... requirement of the Ethics in Government Act of 1978. (a) Applicability. The following employees and...

  13. 30 CFR 252.6 - Freedom of Information Act requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Continental Shelf) and 30 CFR part 251 (Geological and Geophysical Explorations of the Outer Continental Shelf... Section 252.6 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT.... 552), the regulations contained in 43 CFR part 2 (Records and Testimony), the requirements of the...

  14. 78 FR 54252 - Information Collection; American Recovery and Reinvestment Act-Reporting Requirements-One Time...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-03

    ... FR 58389, for the number of respondents required to comply with the requirements of FAR subpart 4.15... Register on September 24, 2010, at 75 FR 58389. No public comments were received in prior years that have...; American Recovery and Reinvestment Act-- Reporting Requirements--One Time Reporting Requirements for...

  15. Using Focus Groups to Investigate the Presence of Formative Feedback in CAA

    ERIC Educational Resources Information Center

    Broughton, Stephen; Hernandez-Martinez, Paul; Robinson, Carol L.

    2012-01-01

    The aim of this project was to examine the effectiveness of feedback offered by computer-aided assessment (CAA). CAA provides practice tests for undergraduates, and feedback to help them improve their scores and mathematical understanding. However, there is a lack of evidence-based literature on the effect of formative feedback in mathematics…

  16. Title III List of Lists: Consolidated list of chemicals subject to the Emergency Planning and Community Right-to-Know Act (EPCRA) and Section 112(r) of the Clean Air Act, as amended. Title III of the Superfund Amendments and Reauthorization Act of 1986, and Title III of the Clean Air Act Amendments of 1990

    SciTech Connect

    1996-12-01

    This consolidated chemical list includes chemicals subject to reporting requirements under Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA), also known as the Emergency Planning and Community Right-to-Know Act (EPCRA) and chemicals listed under Section 112(r) of Title III of the Clean Air Act (CAA) Amendments of 1990. This consolidated list has been prepared to help firms handling chemicals determine whether they need to submit reports under sections 302, 304, or 314 or SARA Title III (EPCRA) and, for a specific chemical, what reports may need to be submitted. It also will also help firms determine whether they will be subject to accident prevention regulations under CAA section 112(r).

  17. The enforcement provisions of the Clean Air Act - not the same old Section 113

    SciTech Connect

    Benthul, H.R.

    1996-08-01

    The Clean Air Act ({open_quotes}CAA{close_quotes}) of 1990 was in many respects a major overhaul of the previous versions of the Clean Air Act although it retained most of the preexisting major programs such as the basic National Ambient Air Quality Standards ({open_quotes}NAAQS{close_quotes}) scheme, PSD, new source performance standards, regulation of toxic air pollutants, and the like. The 1990 Act strengthened the enforcement provisions of the Act by enhancing the enforcement powers of the Environmental Protection Agency ({open_quotes}EPA{close_quotes}) of {section}113. For example, the criminal enforcement provisions of {section}113 are expanded both in the range of punishment and in the kinds of activities which are subject to criminal enforcement. Moreover, the Act now contains a number of additional enforcement provisions in addition to those found in {section}113. The purpose of this paper is to discuss both the {section}113 provision and as well, identify those enforcement provisions found outside {section}113. The latter provisions will be taken up first and addressed by Titles of the Act. The discussion of specific sections and subsections of the CAA are necessarily brief and in the nature of highlighting of particular features; like the rest of the CAA, careful reading and analysis is a requirement for full understanding.

  18. The Clean Air Act`s enforcement ace: An overview of EPA`s credible evidence rule

    SciTech Connect

    Paul, P.J.

    1997-12-31

    The 1990 Clean Air Act ({open_quotes}CAA{close_quotes}) amendments included numerous provisions directing EPA to require owners or operators to conduct enhanced monitoring and to make compliance certifications. These provisions contained in both those Title V (Operating Permits) and Title VII (Enforcement) of those amendments. Section 503(b)(2) of the amended CAA requires at least annual certifications of compliance with permit requirements and prompt reporting of any deviations from such requirements. Section 114(a)(3) of the CAA requires EPA to promulgate rules on enhanced monitoring and compliance certifications. On October 23, 1993, EPA proposed its {open_quotes}enhanced monitoring{close_quotes} rule. The enhanced monitoring proposal also included the Conceptual approach of using {open_quotes}presumptively credible evidence{close_quotes} in enforcement actions. Further, this proposal also would have allowed the use of {open_quotes}credible evidence,{close_quotes} other than reference or compliance test data to establish noncompliance in an enforcement action. In approximately three weeks, EPA is scheduled to republish as a final rule, the credible evidence provisions of the original enhanced monitoring rule with apparently minor revisions. This paper briefly summarizes the history, status, and likely impact EPA`s {open_quotes}any credible evidence{close_quotes} ({open_quotes}ACE{close_quotes}) rule.

  19. 75 FR 5177 - Pipeline Posting Requirements under Section 23 of the Natural Gas Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-01

    ... clarification of Order No. 720. \\1\\ Pipeline Posting Requirements under section 23 of the Natural Gas Act, 73 FR... Natural Gas Act, 73 FR 1116 (Jan. 7, 2008), FERC Stats. & Regs., Proposed Regulations 2004-2007 ] 32,626.... 670, 71 FR 4244 (Jan. 26, 2006), FERC Stats. & Regs. ] 31,202 (2006). \\44\\ TPA Request for...

  20. 48 CFR 352.237-72 - Crime Control Act-requirement for background checks.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Crime Control Act... and Clauses 352.237-72 Crime Control Act—requirement for background checks. As prescribed in 337.103-70(c), the Contracting Officer shall insert the following clause: Crime Control Act of...

  1. 48 CFR 352.237-72 - Crime Control Act-requirement for background checks.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Crime Control Act... and Clauses 352.237-72 Crime Control Act—requirement for background checks. As prescribed in 337.103-70(c), the Contracting Officer shall insert the following clause: Crime Control Act of...

  2. 48 CFR 352.237-72 - Crime Control Act-requirement for background checks.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Crime Control Act... and Clauses 352.237-72 Crime Control Act—requirement for background checks. As prescribed in 337.103-70(c), the Contracting Officer shall insert the following clause: Crime Control Act of...

  3. 48 CFR 352.237-72 - Crime Control Act-requirement for background checks.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Crime Control Act... and Clauses 352.237-72 Crime Control Act—requirement for background checks. As prescribed in 337.103-70(c), the Contracting Officer shall insert the following clause: Crime Control Act of...

  4. 48 CFR 352.237-72 - Crime Control Act-requirement for background checks.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Crime Control Act... and Clauses 352.237-72 Crime Control Act—requirement for background checks. As prescribed in 337.103-70(c), the Contracting Officer shall insert the following clause: Crime Control Act of...

  5. 32 CFR 505.14 - Recordkeeping requirements under the Privacy Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... under the Privacy Act. (a) AR 25-400-2, The Army Records Information Management System (ARIMS). To maintain privacy records are required by the Army Records Information Management System (ARIMS) to...

  6. 32 CFR 505.14 - Recordkeeping requirements under the Privacy Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... under the Privacy Act. (a) AR 25-400-2, The Army Records Information Management System (ARIMS). To maintain privacy records are required by the Army Records Information Management System (ARIMS) to...

  7. 32 CFR 505.14 - Recordkeeping requirements under the Privacy Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... under the Privacy Act. (a) AR 25-400-2, The Army Records Information Management System (ARIMS). To maintain privacy records are required by the Army Records Information Management System (ARIMS) to...

  8. 32 CFR 505.14 - Recordkeeping requirements under the Privacy Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... under the Privacy Act. (a) AR 25-400-2, The Army Records Information Management System (ARIMS). To maintain privacy records are required by the Army Records Information Management System (ARIMS) to...

  9. CaaX-prenyltransferases are essential for expression of genes involvedin the early stages of monoterpenoid biosynthetic pathway in Catharanthus roseus cells.

    PubMed

    Courdavault, Vincent; Thiersault, Martine; Courtois, Martine; Gantet, Pascal; Oudin, Audrey; Doireau, Pierre; St-Pierre, Benoit; Giglioli-Guivarc'h, Nathalie

    2005-04-01

    CaaX-prenyltransferases (CaaX-PTases) catalyse the covalent attachment of isoprenyl groups to conserved cysteine residues located at the C-terminal CaaX motif of a protein substrate. This post-translational modification is required for the function and/or subcellular localization of some transcription factors and components of signal transduction and membrane trafficking machinery. CaaX-PTases, including protein farnesyltransferase (PFT) and type-I protein geranylgeranyltransferase (PGGT-I), are heterodimeric enzymes composed of a common alpha subunit and a specific beta subunit. We have established RNA interference cell lines targeting the beta subunits of PFT and PGGT-I, respectively, in the Catharanthus roseus C20D cell line, which synthesizes monoterpenoid indole alkaloids in response to auxin depletion from the culture medium. In both types of RNAi cell lines, expression of a subset of genes involved in the early stage of monoterpenoid biosynthetic pathway (ESMB genes), including the MEP pathway, is strongly decreased. The role of CaaX-PTases in ESMB gene regulation was confirmed by using the general prenyltransferase inhibitor s-perillyl alcohol (SP) and the specific PFT inhibitor Manumycin A on the wild type line. Furthermore, supplementation of SP inhibited cells with monoterpenoid intermediates downstream of the steps encoded by the ESMB genes restores monoterpenoid indole alkaloids biosynthesis. We conclude that protein targets for both PFT and PGGT-I are required for the expression of ESMB genes and monoterpenoid biosynthesis in C. roseus, this represents a non previously described role for protein prenyltransferase in plants.

  10. Title III (SARA and Clean Air Act Amendments) Emergency Planning and Community Right-to-Know Act and accidental release prevention consolidated chemical list (for microcomputers). Data file

    SciTech Connect

    1995-04-01

    This consolidated chemical list includes chemicals subject to reporting requirements under Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA), also known as the Emergency Planning and Community Right-to-Know Act (EPCRA), and chemicals listed under section 112(r) of Title III of the Clean Air Act (CAA) Amendments of 1990. This consolidated list has been prepared to help firms handling chemicals determine whether they need to submit reports under sections 302, 304, or 313 of SARA Title III (EPCRA) and, for a specific chemical, what reports may need to be submitted. It will also help firms determine wether they will be subject to accident prevention regulations under CAA section 112(r). Separate lists are also provided of Resource Conservation and Recovery Act (RCRA) waste streams and unlisted hazardous wastes, and of radionuclides reportable under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). These lists should be used as a reference tool, not as a definitive source of compliance information. Compliance information for EPCRA is published in the Code of Federal Regulations (CFR), 40 CFR Parts 302, 355, and 372. Compliance information for CAA section 112(r) will be published in 40 CFR Part 68. This revision reflects regulatory changes through December 1994. The chemicals on the consolidated list are ordered by Chemical Abstract Service (CAS) registry number. Categories of chemicals, which do not have CAS registry numbers, but which are cited under CERCLA, EPCRA section 313, and the CAA, are placed at the end of the list. For reference purposes, the chemicals (with their CAS numbers) are ordered alphabetically following the CAS-order list. Long chemical names may have been truncated to facilitate printing of this list. The list includes chemicals referenced under five federal statutory provisions.

  11. 21 CFR 21.71 - Disclosure of records in Privacy Act Record Systems; accounting required.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Systems; accounting required. 21.71 Section 21.71 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT... Record Systems; accounting required. (a) Except as provided in § 21.70, a record about an individual that... of the disclosure. The accounting shall not be considered a Privacy Act Record System. (2) Retain...

  12. 24 CFR 5.212 - Compliance with the Privacy Act and other requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Compliance with the Privacy Act and other requirements. 5.212 Section 5.212 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development GENERAL HUD PROGRAM REQUIREMENTS; WAIVERS Disclosure...

  13. 76 FR 25688 - Proposed Settlement Agreement, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-05

    ... AGENCY Proposed Settlement Agreement, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency... accordance with section 113(g) of the Clean Air Act, as amended (``CAA''), 42 U.S.C. 7413(g), notice is... to a CAA Title V operating permit issued by the Southwest Clean Air Agency to Transalta...

  14. Citizen suit Clean Air Act enforcement: An update

    SciTech Connect

    Wright, W.G. Jr.

    1999-07-01

    Almost every federal environmental statute has a provision that allows citizens to sue violators in lieu of governmental enforcement authorities under certain circumstances. Generally, if the relevant governmental enforcement authority was not deemed to be diligently prosecuting enforcement action against an alleged violator and certain procedural requirements were met a citizens suit could be filed in federal court. If a violation was proved penalties could be assessed against the violator and the plaintiff citizen could receive reimbursement of both his or her attorney's fees and other expenses. Historically, however, the only federal statute that has been the subject of significant citizens suit activity has been the federal Clean Water Act (CWA). This paper will explore a variety of events that are expected to significantly increase the number of citizen suits CAA permitted facilities will face over the next ten years. The paper will briefly address the role the Title V operating permit will play. It will also include a discussion of how this permit will now encompass specific emission limitations along with a mandate to report exceedances. Further, and equally important, will be the role of the 1997 federal Environmental Protection Agency any credible evidence rule which potentially broadens the type, amount, and accessibility available to a CAA citizen suit plaintiff. This rule along with the additional monitoring data that will be generated by the Title V periodic and compliance assurance monitoring requirements will be an issue. Two important CAA citizen suits will be discussed which illustrate the potential role of credible evidence. Also, recent citizen suit decisions involving other federal environmental statutes with implications for the CAA will be examined. Further, the paper will provide some thoughts on how facilities can protect themselves to the extent possible against citizen suits.

  15. 20 CFR 670.420 - Are there any special requirements for enrollment related to the Military Selective Service Act?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... enrollment related to the Military Selective Service Act? 670.420 Section 670.420 Employees' Benefits... there any special requirements for enrollment related to the Military Selective Service Act? (a) Yes... of the Military Selective Service Act (50 U.S.C. App. 451 et seq.) if required; and (b) When a...

  16. 20 CFR 670.420 - Are there any special requirements for enrollment related to the Military Selective Service Act?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... enrollment related to the Military Selective Service Act? 670.420 Section 670.420 Employees' Benefits....420 Are there any special requirements for enrollment related to the Military Selective Service Act... section 3 of the Military Selective Service Act (50 U.S.C. App. 451 et seq.) if required; and (b) When...

  17. 20 CFR 670.420 - Are there any special requirements for enrollment related to the Military Selective Service Act?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... enrollment related to the Military Selective Service Act? 670.420 Section 670.420 Employees' Benefits... there any special requirements for enrollment related to the Military Selective Service Act? (a) Yes... of the Military Selective Service Act (50 U.S.C. App. 451 et seq.) if required; and (b) When a...

  18. 20 CFR 670.420 - Are there any special requirements for enrollment related to the Military Selective Service Act?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... enrollment related to the Military Selective Service Act? 670.420 Section 670.420 Employees' Benefits....420 Are there any special requirements for enrollment related to the Military Selective Service Act... section 3 of the Military Selective Service Act (50 U.S.C. App. 451 et seq.) if required; and (b) When...

  19. 20 CFR 670.420 - Are there any special requirements for enrollment related to the Military Selective Service Act?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... enrollment related to the Military Selective Service Act? 670.420 Section 670.420 Employees' Benefits....420 Are there any special requirements for enrollment related to the Military Selective Service Act... section 3 of the Military Selective Service Act (50 U.S.C. App. 451 et seq.) if required; and (b) When...

  20. 18 CFR Appendix A to Part 380 - Minimum Filing Requirements for Environmental Reports Under the Natural Gas Act

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Requirements for Environmental Reports Under the Natural Gas Act A Appendix A to Part 380 Conservation of Power... Filing Requirements for Environmental Reports Under the Natural Gas Act Environmental Reports Under the Natural Gas Act. Resource Report 1—General Project Description 1. Provide a detailed description...

  1. 18 CFR Appendix A to Part 380 - Minimum Filing Requirements for Environmental Reports Under the Natural Gas Act

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Requirements for Environmental Reports Under the Natural Gas Act A Appendix A to Part 380 Conservation of Power... Filing Requirements for Environmental Reports Under the Natural Gas Act Environmental Reports Under the Natural Gas Act. Resource Report 1—General Project Description 1. Provide a detailed description...

  2. 2 CFR 176.50 - Award term-Reporting and registration requirements under section 1512 of the Recovery Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... Agencies are responsible for ensuring that their recipients report information required under the Recovery... Act) and to report on use of Recovery Act funds provided through this award. Information from these... requirements under section 1512 of the Recovery Act. 176.50 Section 176.50 Grants and Agreements OFFICE...

  3. 2 CFR 176.50 - Award term-Reporting and registration requirements under section 1512 of the Recovery Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... requirements under section 1512 of the Recovery Act. 176.50 Section 176.50 Grants and Agreements Office of... AMERICAN RECOVERY AND REINVESTMENT ACT OF 2009, PUBLIC LAW 111-5 Reporting and Registration Requirements Under Section 1512 of the American Recovery and Reinvestment Act of 2009 § 176.50 Award...

  4. 2 CFR 176.50 - Award term-Reporting and registration requirements under section 1512 of the Recovery Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... requirements under section 1512 of the Recovery Act. 176.50 Section 176.50 Grants and Agreements Office of... THE AMERICAN RECOVERY AND REINVESTMENT ACT OF 2009, PUBLIC LAW 111-5 Reporting and Registration Requirements Under Section 1512 of the American Recovery and Reinvestment Act of 2009 § 176.50 Award...

  5. 7 CFR 27.3 - Requirements of subsection 15b(f) of the Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Requirements of subsection 15b(f) of the Act. 27.3 Section 27.3 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND...

  6. EVALUATION OF A PROTOCOL FOR DRINKING WATER TREATMENT DATA REQUIRED BY THE FOOD QUALITY PROTECTION ACT

    EPA Science Inventory

    Under the Food Quality Protection Act (FQPA), the USEPA Office of Pesticide Programs (OPP) considers drinking water as a route for pesticide exposure in its human health risk assessments, and may require data on the fate of a pesticide in drinking water be supplied to OPP by the ...

  7. 77 FR 27787 - Agency Information Collection Activities: Customs Modernization Act Recordkeeping Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-11

    ... collection was previously published in the Federal Register (77 FR 13617) on March 7, 2012, allowing for a 60... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Customs Modernization Act Recordkeeping Requirements AGENCY: U.S. Customs and Border Protection, Department of...

  8. 29 CFR 1977.3 - General requirements of section 11(c) of the Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false General requirements of section 11(c) of the Act. 1977.3 Section 1977.3 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) DISCRIMINATION AGAINST EMPLOYEES EXERCISING RIGHTS UNDER...

  9. 29 CFR 1977.3 - General requirements of section 11(c) of the Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 9 2011-07-01 2011-07-01 false General requirements of section 11(c) of the Act. 1977.3 Section 1977.3 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) DISCRIMINATION AGAINST EMPLOYEES EXERCISING RIGHTS UNDER...

  10. 29 CFR 1977.3 - General requirements of section 11(c) of the Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false General requirements of section 11(c) of the Act. 1977.3 Section 1977.3 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) DISCRIMINATION AGAINST EMPLOYEES EXERCISING RIGHTS UNDER...

  11. 29 CFR 1977.3 - General requirements of section 11(c) of the Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 9 2013-07-01 2013-07-01 false General requirements of section 11(c) of the Act. 1977.3 Section 1977.3 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) DISCRIMINATION AGAINST EMPLOYEES EXERCISING RIGHTS UNDER...

  12. 29 CFR 1977.3 - General requirements of section 11(c) of the Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 9 2012-07-01 2012-07-01 false General requirements of section 11(c) of the Act. 1977.3 Section 1977.3 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) DISCRIMINATION AGAINST EMPLOYEES EXERCISING RIGHTS UNDER...

  13. 47 CFR 20.15 - Requirements under Title II of the Communications Act.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CARRIER SERVICES COMMERCIAL MOBILE RADIO SERVICES § 20.15 Requirements under Title II of the Communications Act. (a) Commercial mobile radio services providers, to the extent applicable, must comply with... CFR part 68; and §§ 1.701-1.748, and 1.815 of this chapter, 47 CFR 1.701-1.748, 1.815. (b)...

  14. 47 CFR 20.15 - Requirements under Title II of the Communications Act.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... CARRIER SERVICES COMMERCIAL MOBILE SERVICES § 20.15 Requirements under Title II of the Communications Act. (a) Commercial mobile radio services providers, to the extent applicable, must comply with sections....C. 201, 202, 206, 207, 208, 209, 216, 217, 223, 225, 226, 227, 228; part 68 of this chapter, 47...

  15. 27 CFR 26.202 - Requirements of the Federal Alcohol Administration Act.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Requirements of the Federal Alcohol Administration Act. 26.202 Section 26.202 Alcohol, Tobacco Products and Firearms ALCOHOL... RICO AND THE VIRGIN ISLANDS Products Coming Into the United States From the Virgin Islands §...

  16. 32 CFR 635.3 - Special requirements of the Privacy Act of 1974.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... used. (c) Army law enforcement personnel performing official duties often require an individual's SSN... contained thereon (for example, the sponsor's SSN) may be used to verify and complete applicable sections of... advised of the provisions of the Privacy Act Statement when requested to disclose their SSN. (d)...

  17. 32 CFR 635.3 - Special requirements of the Privacy Act of 1974.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... used. (c) Army law enforcement personnel performing official duties often require an individual's SSN... contained thereon (for example, the sponsor's SSN) may be used to verify and complete applicable sections of... advised of the provisions of the Privacy Act Statement when requested to disclose their SSN. (d)...

  18. 32 CFR 635.3 - Special requirements of the Privacy Act of 1974.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... used. (c) Army law enforcement personnel performing official duties often require an individual's SSN... contained thereon (for example, the sponsor's SSN) may be used to verify and complete applicable sections of... advised of the provisions of the Privacy Act Statement when requested to disclose their SSN. (d)...

  19. 32 CFR 635.3 - Special requirements of the Privacy Act of 1974.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... used. (c) Army law enforcement personnel performing official duties often require an individual's SSN... contained thereon (for example, the sponsor's SSN) may be used to verify and complete applicable sections of... advised of the provisions of the Privacy Act Statement when requested to disclose their SSN. (d)...

  20. 32 CFR 635.3 - Special requirements of the Privacy Act of 1974.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... used. (c) Army law enforcement personnel performing official duties often require an individual's SSN... contained thereon (for example, the sponsor's SSN) may be used to verify and complete applicable sections of... advised of the provisions of the Privacy Act Statement when requested to disclose their SSN. (d)...

  1. 76 FR 33413 - Proposed Renewal Without Change; Comment Request; Nine Bank Secrecy Act Recordkeeping Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-08

    ... Financial Crimes Enforcement Network Proposed Renewal Without Change; Comment Request; Nine Bank Secrecy Act... be submitted to: Financial Crimes Enforcement Network, P.O. Box 39, Vienna, VA 22183, Attention: BSA... Requirements Comments.'' FOR FURTHER INFORMATION CONTACT: Financial Crimes Enforcement Network,...

  2. 48 CFR 52.204-11 - American Recovery and Reinvestment Act-Reporting Requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Contractor shall report the following information, using the online reporting tool available at http://www... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false American Recovery and Reinvestment Act-Reporting Requirements. 52.204-11 Section 52.204-11 Federal Acquisition Regulations...

  3. 48 CFR 52.204-11 - American Recovery and Reinvestment Act-Reporting Requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Contractor shall report the following information, using the online reporting tool available at http://www... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false American Recovery and Reinvestment Act-Reporting Requirements. 52.204-11 Section 52.204-11 Federal Acquisition Regulations...

  4. 48 CFR 52.204-11 - American Recovery and Reinvestment Act-Reporting Requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Contractor shall report the following information, using the online reporting tool available at http://www... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false American Recovery and Reinvestment Act-Reporting Requirements. 52.204-11 Section 52.204-11 Federal Acquisition Regulations...

  5. The Reasonable Accommodation Requirements of Section 504 of the Rehabilitation Act.

    ERIC Educational Resources Information Center

    Wenkart, Ronald D.

    1990-01-01

    The reasonable accommodation requirements of Section 504 of the Rehabilitation Act of 1973 have recently been applied to public schools. Among the rulings were the provision of a sign language interpreter to hearing-impaired parents and the allowance of a service dog onto a school campus. (MLF)

  6. 78 FR 27308 - Loan Originator Compensation Requirements Under the Truth In Lending Act (Regulation Z...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-10

    ... adopting Sec. 1026.36(i). \\1\\ 78 FR 11279 (Feb. 15, 2013). A. Title XIV Rulemaking Effective Dates In... become effective sooner than January 2014.\\5\\ \\5\\ 77 FR 55272 (Sept. 7, 2012). The Bureau received very... Requirements Under the Truth In Lending Act (Regulation Z); Prohibition on Financing Credit Insurance...

  7. 75 FR 55663 - Requirements for Federal Funding Accountability and Transparency Act Implementation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-14

    ... of State officials; 16 institutions of higher education and an association of research universities... required for Transparency Act reporting of subawards and executive compensation [75 FR 43165]. The Federal... institutions of higher education noted that the limitation in OMB Circular A-21 on recovery of indirect...

  8. 21 CFR 21.71 - Disclosure of records in Privacy Act Record Systems; accounting required.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Disclosure of records in Privacy Act Record Systems; accounting required. 21.71 Section 21.71 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT... Record Systems to Persons Other Than the Subject Individual § 21.71 Disclosure of records in Privacy...

  9. 21 CFR 21.71 - Disclosure of records in Privacy Act Record Systems; accounting required.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Disclosure of records in Privacy Act Record Systems; accounting required. 21.71 Section 21.71 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT... Record Systems to Persons Other Than the Subject Individual § 21.71 Disclosure of records in Privacy...

  10. 21 CFR 21.71 - Disclosure of records in Privacy Act Record Systems; accounting required.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Disclosure of records in Privacy Act Record Systems; accounting required. 21.71 Section 21.71 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT... Record Systems to Persons Other Than the Subject Individual § 21.71 Disclosure of records in Privacy...

  11. 21 CFR 21.71 - Disclosure of records in Privacy Act Record Systems; accounting required.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Disclosure of records in Privacy Act Record Systems; accounting required. 21.71 Section 21.71 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT... Record Systems to Persons Other Than the Subject Individual § 21.71 Disclosure of records in Privacy...

  12. 78 FR 27001 - Horse Protection Act; Requiring Horse Industry Organizations To Assess and Enforce Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-09

    ... published in the Federal Register on June 7, 2012 (77 FR 33607-33619, Docket No. APHIS-2011-0030), and... Inspection Service 9 CFR Part 11 RIN 0579-AD43 Horse Protection Act; Requiring Horse Industry Organizations... Federal Register on June 7, 2012, and effective on July 9, 2012, we amended the horse...

  13. 48 CFR 52.225-10 - Notice of Buy American Act Requirement-Construction Materials.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Requirement-Construction Materials. 52.225-10 Section 52.225-10 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.225-10 Notice of Buy American Act Requirement—Construction Materials. As prescribed... Materials (FEB 2009) (a) Definitions. “Commercially available off-the-shelf (COTS) item,”...

  14. 48 CFR 52.225-10 - Notice of Buy American Act Requirement-Construction Materials.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Requirement-Construction Materials. 52.225-10 Section 52.225-10 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.225-10 Notice of Buy American Act Requirement—Construction Materials. As prescribed... Materials (FEB 2009) (a) Definitions. “Commercially available off-the-shelf (COTS) item,”...

  15. 48 CFR 52.225-10 - Notice of Buy American Act Requirement-Construction Materials.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Requirement-Construction Materials. 52.225-10 Section 52.225-10 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.225-10 Notice of Buy American Act Requirement—Construction Materials. As prescribed... Materials (FEB 2009) (a) Definitions. “Commercially available off-the-shelf (COTS) item,”...

  16. 48 CFR 52.225-10 - Notice of Buy American Act Requirement-Construction Materials.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Requirement-Construction Materials. 52.225-10 Section 52.225-10 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.225-10 Notice of Buy American Act Requirement—Construction Materials. As prescribed... Materials (FEB 2009) (a) Definitions. “Commercially available off-the-shelf (COTS) item,”...

  17. MetaCAA: A clustering-aided methodology for efficient assembly of metagenomic datasets.

    PubMed

    Reddy, Rachamalla Maheedhar; Mohammed, Monzoorul Haque; Mande, Sharmila S

    2014-01-01

    A key challenge in analyzing metagenomics data pertains to assembly of sequenced DNA fragments (i.e. reads) originating from various microbes in a given environmental sample. Several existing methodologies can assemble reads originating from a single genome. However, these methodologies cannot be applied for efficient assembly of metagenomic sequence datasets. In this study, we present MetaCAA - a clustering-aided methodology which helps in improving the quality of metagenomic sequence assembly. MetaCAA initially groups sequences constituting a given metagenome into smaller clusters. Subsequently, sequences in each cluster are independently assembled using CAP3, an existing single genome assembly program. Contigs formed in each of the clusters along with the unassembled reads are then subjected to another round of assembly for generating the final set of contigs. Validation using simulated and real-world metagenomic datasets indicates that MetaCAA aids in improving the overall quality of assembly. A software implementation of MetaCAA is available at https://metagenomics.atc.tcs.com/MetaCAA.

  18. The actin gene ACT1 is required for phagocytosis, motility, and cell separation of Tetrahymena thermophila.

    PubMed

    Williams, Norman E; Tsao, Che-Chia; Bowen, Josephine; Hehman, Gery L; Williams, Ruth J; Frankel, Joseph

    2006-03-01

    A previously identified Tetrahymena thermophila actin gene (C. G. Cupples and R. E. Pearlman, Proc. Natl. Acad. Sci. USA 83:5160-5164, 1986), here called ACT1, was disrupted by insertion of a neo3 cassette. Cells in which all expressed copies of this gene were disrupted exhibited intermittent and extremely slow motility and severely curtailed phagocytic uptake. Transformation of these cells with inducible genetic constructs that contained a normal ACT1 gene restored motility. Use of an epitope-tagged construct permitted visualization of Act1p in the isolated axonemes of these rescued cells. In ACT1Delta mutant cells, ultrastructural abnormalities of outer doublet microtubules were present in some of the axonemes. Nonetheless, these cells were still able to assemble cilia after deciliation. The nearly paralyzed ACT1Delta cells completed cleavage furrowing normally, but the presumptive daughter cells often failed to separate from one another and later became reintegrated. Clonal analysis revealed that the cell cycle length of the ACT1Delta cells was approximately double that of wild-type controls. Clones could nonetheless be maintained for up to 15 successive fissions, suggesting that the ACT1 gene is not essential for cell viability or growth. Examination of the cell cortex with monoclonal antibodies revealed that whereas elongation of ciliary rows and formation of oral structures were normal, the ciliary rows of reintegrated daughter cells became laterally displaced and sometimes rejoined indiscriminately across the former division furrow. We conclude that Act1p is required in Tetrahymena thermophila primarily for normal ciliary motility and for phagocytosis and secondarily for the final separation of daughter cells.

  19. 78 FR 54828 - Promulgation of State Implementation Plan Revisions; Infrastructure Requirements for the 1997 and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-06

    ...EPA is proposing to partially approve and partially disapprove State Implementation Plan (SIP) submissions from the State of Wyoming to demonstrate that the SIP meets the infrastructure requirements of the Clean Air Act (CAA) for the National Ambient Air Quality Standards (NAAQS) promulgated for particulate matter less than or equal to 2.5 micrometers ([mu]m) in diameter (PM2.5) on......

  20. 78 FR 54484 - Notice of Lodging of Consent Decree Under the Clean Air Act (CAA)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-04

    ..., 2013, a proposed consent decree (``proposed Decree'') in United States and the People of the State of... Chi Zheng, C.A. No. 1:11-cv-08023 GHK was lodged with the United States District Court for the Central.... and Chi Zheng, individually, for alleged violations arising from Defendants' motor vehicle...

  1. 20 CFR 667.250 - What requirements relate to the enforcement of the Military Selective Service Act?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... of the Military Selective Service Act? 667.250 Section 667.250 Employees' Benefits EMPLOYMENT AND... enforcement of the Military Selective Service Act? The requirements relating to the enforcement of the Military Selective Service Act are found at WIA section 189(h)....

  2. 20 CFR 667.250 - What requirements relate to the enforcement of the Military Selective Service Act?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... of the Military Selective Service Act? 667.250 Section 667.250 Employees' Benefits EMPLOYMENT AND... the enforcement of the Military Selective Service Act? The requirements relating to the enforcement of the Military Selective Service Act are found at WIA section 189(h)....

  3. 20 CFR 667.250 - What requirements relate to the enforcement of the Military Selective Service Act?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... of the Military Selective Service Act? 667.250 Section 667.250 Employees' Benefits EMPLOYMENT AND... the enforcement of the Military Selective Service Act? The requirements relating to the enforcement of the Military Selective Service Act are found at WIA section 189(h)....

  4. 20 CFR 667.250 - What requirements relate to the enforcement of the Military Selective Service Act?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... of the Military Selective Service Act? 667.250 Section 667.250 Employees' Benefits EMPLOYMENT AND... the enforcement of the Military Selective Service Act? The requirements relating to the enforcement of the Military Selective Service Act are found at WIA section 189(h)....

  5. 20 CFR 667.250 - What requirements relate to the enforcement of the Military Selective Service Act?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... of the Military Selective Service Act? 667.250 Section 667.250 Employees' Benefits EMPLOYMENT AND... enforcement of the Military Selective Service Act? The requirements relating to the enforcement of the Military Selective Service Act are found at WIA section 189(h)....

  6. 2 CFR 176.50 - Award term-Reporting and registration requirements under section 1512 of the Recovery Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... responsible for ensuring that their recipients report information required under the Recovery Act in a timely... report on use of Recovery Act funds provided through this award. Information from these reports will be... awards funded with Recovery Act funds. A Dun and Bradstreet Data Universal Numbering System (DUNS)...

  7. 2 CFR 176.50 - Award term-Reporting and registration requirements under section 1512 of the Recovery Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... responsible for ensuring that their recipients report information required under the Recovery Act in a timely... report on use of Recovery Act funds provided through this award. Information from these reports will be... awards funded with Recovery Act funds. A Dun and Bradstreet Data Universal Numbering System (DUNS)...

  8. 2 CFR 176.190 - Award term-Wage rate requirements under Section 1606 of the Recovery Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... THAT INCLUDE FUNDS UNDER THE AMERICAN RECOVERY AND REINVESTMENT ACT OF 2009, PUBLIC LAW 111-5 Wage Rate... rate requirements under Section 1606 of the Recovery Act. When issuing announcements or requesting... Copeland Act, 40 U.S.C. 3145, the Department of Labor has issued regulations at 29 CFR parts 1, 3, and 5...

  9. CFD-CAA Coupled Calculations of a Tandem Cylinder Configuration to Assess Facility Installation Effects

    NASA Technical Reports Server (NTRS)

    Redonnet, Stephane; Lockard, David P.; Khorrami, Mehdi R.; Choudhari, Meelan M.

    2011-01-01

    This paper presents a numerical assessment of acoustic installation effects in the tandem cylinder (TC) experiments conducted in the NASA Langley Quiet Flow Facility (QFF), an open-jet, anechoic wind tunnel. Calculations that couple the Computational Fluid Dynamics (CFD) and Computational Aeroacoustics (CAA) of the TC configuration within the QFF are conducted using the CFD simulation results previously obtained at NASA LaRC. The coupled simulations enable the assessment of installation effects associated with several specific features in the QFF facility that may have impacted the measured acoustic signature during the experiment. The CFD-CAA coupling is based on CFD data along a suitably chosen surface, and employs a technique that was recently improved to account for installed configurations involving acoustic backscatter into the CFD domain. First, a CFD-CAA calculation is conducted for an isolated TC configuration to assess the coupling approach, as well as to generate a reference solution for subsequent assessments of QFF installation effects. Direct comparisons between the CFD-CAA calculations associated with the various installed configurations allow the assessment of the effects of each component (nozzle, collector, etc.) or feature (confined vs. free jet flow, etc.) characterizing the NASA LaRC QFF facility.

  10. 40 CFR 59.1 - Final determinations under Section 183(e)(3)(C) of the CAA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 5 2010-07-01 2010-07-01 false Final determinations under Section 183(e)(3)(C) of the CAA. 59.1 Section 59.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL VOLATILE ORGANIC COMPOUND EMISSION STANDARDS FOR CONSUMER...

  11. 40 CFR 59.1 - Final determinations under Section 183(e)(3)(C) of the CAA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 6 2013-07-01 2013-07-01 false Final determinations under Section 183(e)(3)(C) of the CAA. 59.1 Section 59.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL VOLATILE ORGANIC COMPOUND EMISSION STANDARDS FOR CONSUMER...

  12. Requirements and impacts of the Federal Facility Compliance Act on the Department of Energy

    SciTech Connect

    Chang, L.; Tripp, S.C.

    1993-03-01

    The Federal Facilities Compliance Act (FFCA, the Act) was signed into law on October 6, 1992, primarily as a means of waiving sovereign immunity for federal facilities with respect to requirements under the Resource Conservation and Recovery Act. DOE`s implementation of the FFCA will have significant effects on current and future DOE waste management operations. DOE will need to rethink its strategy in the area of future compliance agreements to ensure commitments and deliverables are made consistent throughout the different DOE facilities. Several types of agreements that address mixed waste land disposal restriction (LDR) compliance have already been signed by both DOE and the regulators. These agreements are in place at the Hanford Reservation, the Savannah River Site, the Oak Ridge Reservation (Oak Ridge National Laboratory, K-25, Y-12), and the Paducah Gaseous Diffusion Plant. The Rocky Flats Agreement is now being renegotiated. Los Alamos National Laboratory, Sandia/Albuquerque National Laboratory, Lawrence Livermore National Laboratory, and Idaho National Engineering Laboratory agreements are in progress. Major components of the FFCA include provisions on: sovereign immunity waiver; cost reimbursements; mixed waste requirements, including inventory reports on mixed waste and treatment capacity and technologies; and plans for the development of treatment capacities and technologies. Each of these components is discussed within this paper.

  13. Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates

    PubMed Central

    Krzysiak, Amanda J.; Aditya, Animesh V.; Hougland, James L.; Fierke, Carol A.; Gibbs, Richard A.

    2010-01-01

    Proteins bearing a CaaL sequence are typically geranylgeranylated to enable their proper localization and function. We found that many of the dansyl-GCaaL peptides representing mammalian CaaL proteins can be farnesylated by FTase. This result may have important implications for prenylated protein biology. PMID:20005705

  14. 29 CFR 785.5 - General requirements of sections 6 and 7 of the Fair Labor Standards Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the Fair Labor Standards Act. Section 6 requires the payment of a minimum wage by an employer to his... 29 Labor 3 2013-07-01 2013-07-01 false General requirements of sections 6 and 7 of the Fair Labor Standards Act. 785.5 Section 785.5 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR...

  15. 29 CFR 785.5 - General requirements of sections 6 and 7 of the Fair Labor Standards Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the Fair Labor Standards Act. Section 6 requires the payment of a minimum wage by an employer to his... 29 Labor 3 2012-07-01 2012-07-01 false General requirements of sections 6 and 7 of the Fair Labor Standards Act. 785.5 Section 785.5 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR...

  16. 29 CFR 785.5 - General requirements of sections 6 and 7 of the Fair Labor Standards Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the Fair Labor Standards Act. Section 6 requires the payment of a minimum wage by an employer to his... 29 Labor 3 2014-07-01 2014-07-01 false General requirements of sections 6 and 7 of the Fair Labor Standards Act. 785.5 Section 785.5 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR...

  17. 29 CFR 785.5 - General requirements of sections 6 and 7 of the Fair Labor Standards Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the Fair Labor Standards Act. Section 6 requires the payment of a minimum wage by an employer to his... 29 Labor 3 2010-07-01 2010-07-01 false General requirements of sections 6 and 7 of the Fair Labor Standards Act. 785.5 Section 785.5 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR...

  18. 29 CFR 785.5 - General requirements of sections 6 and 7 of the Fair Labor Standards Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the Fair Labor Standards Act. Section 6 requires the payment of a minimum wage by an employer to his... 29 Labor 3 2011-07-01 2011-07-01 false General requirements of sections 6 and 7 of the Fair Labor Standards Act. 785.5 Section 785.5 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR...

  19. 2 CFR 176.190 - Award term-Wage rate requirements under Section 1606 of the Recovery Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... RECOVERY AND REINVESTMENT ACT OF 2009, PUBLIC LAW 111-5 Wage Rate Requirements Under Section 1606 of the American Recovery and Reinvestment Act of 2009 § 176.190 Award term—Wage rate requirements under Section.... 3145, the Department of Labor has issued regulations at 29 CFR parts 1, 3, and 5 to implement the...

  20. Modeling Requirements for Simulating the Effects of Extreme Acts of Terrorism: A White Paper

    SciTech Connect

    Allen, M.; Hiebert-Dodd, K.; Marozas, D.; Paananen, O.; Pryor, R.J.; Reinert, R.K.

    1998-10-01

    This white paper presents the initial requirements for developing a new computer model for simulating the effects of extreme acts of terrorism in the United States. General characteristics of the model are proposed and the level of effort to prepare a complete written description of the model, prior to coding, is detailed. The model would simulate the decision processes and interactions of complex U. S. systems engaged in responding to and recovering from four types of terrorist incidents. The incident scenarios span the space of extreme acts of terrorism that have the potential to affect not only the impacted area, but also the entire nation. The model would be useful to decision-makers in assessing and analyzing the vulnerability of the nation's complex infrastructures, in prioritizing resources to reduce risk, and in planning strategies for immediate response and for subsequent recovery from terrorist incidents.

  1. Implementing the Affordable Care Act: Revisiting the ACA's Essential Health Benefits Requirements.

    PubMed

    Giovannelli, Justin; Lucia, Kevin W; Corlette, Sabrina

    2014-10-01

    The Affordable Care Act broadens and strengthens the health insurance benefits available to consumers by requiring insurers to provide coverage of a minimum set of medical services known as "essential health benefits." Federal officials implemented this reform using transitional policies that left many important decisions to the states, while pledging to reassess that approach in time for the 2016 coverage year. This issue brief examines how states have exercised their options under the initial federal essential health benefits framework. We find significant variation in how states have developed their essential health benefits packages, including their approaches to benefit substitution and coverage of habilitative services. Federal regulators should use insurance company data describing enrollees' experiences with their coverage--information called for under the law's delayed transparency requirements--to determine whether states' differing strategies are producing the coverage improvements promised by reform. PMID:26259257

  2. 47 CFR 54.520 - Children's Internet Protection Act certifications required from recipients of discounts under the...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 3 2011-10-01 2011-10-01 false Children's Internet Protection Act... Libraries § 54.520 Children's Internet Protection Act certifications required from recipients of discounts... “technology protection measure” as used in this section, are defined in the Children's Internet Protection...

  3. 47 CFR 54.520 - Children's Internet Protection Act certifications required from recipients of discounts under the...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Children's Internet Protection Act... Libraries § 54.520 Children's Internet Protection Act certifications required from recipients of discounts... “technology protection measure” as used in this section, are defined in the Children's Internet Protection...

  4. 47 CFR 54.520 - Children's Internet Protection Act certifications required from recipients of discounts under the...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 3 2014-10-01 2014-10-01 false Children's Internet Protection Act... Libraries § 54.520 Children's Internet Protection Act certifications required from recipients of discounts... technology that blocks or filters Internet access to the material covered by a certification under...

  5. 47 CFR 54.520 - Children's Internet Protection Act certifications required from recipients of discounts under the...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 3 2013-10-01 2013-10-01 false Children's Internet Protection Act... Libraries § 54.520 Children's Internet Protection Act certifications required from recipients of discounts... technology that blocks or filters Internet access to the material covered by a certification under...

  6. 47 CFR 54.520 - Children's Internet Protection Act certifications required from recipients of discounts under the...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 3 2012-10-01 2012-10-01 false Children's Internet Protection Act... Libraries § 54.520 Children's Internet Protection Act certifications required from recipients of discounts... technology that blocks or filters Internet access to the material covered by a certification under...

  7. 2 CFR 176.190 - Award term-Wage rate requirements under Section 1606 of the Recovery Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... FUNDS UNDER THE AMERICAN RECOVERY AND REINVESTMENT ACT OF 2009, PUBLIC LAW 111-5 Wage Rate Requirements Under Section 1606 of the American Recovery and Reinvestment Act of 2009 § 176.190 Award term—Wage rate....S.C. 3145, the Department of Labor has issued regulations at 29 CFR parts 1, 3, and 5 to...

  8. 2 CFR 176.190 - Award term-Wage rate requirements under Section 1606 of the Recovery Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... FUNDS UNDER THE AMERICAN RECOVERY AND REINVESTMENT ACT OF 2009, PUBLIC LAW 111-5 Wage Rate Requirements Under Section 1606 of the American Recovery and Reinvestment Act of 2009 § 176.190 Award term—Wage rate....S.C. 3145, the Department of Labor has issued regulations at 29 CFR parts 1, 3, and 5 to...

  9. The caa3 terminal oxidase of Bacillus stearothermophilus. Transient spectroscopy of electron transfer and ligand binding.

    PubMed

    Giuffrè, A; D'Itri, E; Giannini, S; Brunori, M; Ubbink-Kok, T; Konings, W N; Antonini, G

    1996-06-14

    The thermophilic bacterium Bacillus stearothermophilus possesses a caa3-type terminal oxidase, which was previously purified (De Vrij, W., Heyne, R. I. R., and Konings, W. N. (1989) Eur. J. Biochem. 178, 763-770). We have carried out extensive kinetic experiments on the purified enzyme by stopped-flow time-resolved optical spectroscopy combined with singular value decomposition analysis. The results indicate a striking similarity of behavior between this enzyme and the electrostatic complex between mammalian cytochrome c and cytochrome c oxidase. CO binding to fully reduced caa3 occurs with a second order rate constant (k = 7.8 x 10(4)M-1 s-1) and an activation energy (E* = 6.1 kcal mol-1) similar to those reported for beef heart cytochrome c oxidase. Dithionite reduces cytochrome a with bimolecular kinetics, while cytochrome a3 (and CuB) is reduced via intramolecular electron transfer. When the fully reduced enzyme is mixed with O2, cytochrome a3, and cytochrome c are rapidly oxidized, whereas cytochrome a remains largely reduced in the first few milliseconds. When cyanide-bound caa3 is mixed with ascorbate plus TMPD, cytochrome c and cytochrome a are synchronously reduced; the value of the second order rate constant (k = 3 x 10(5) M-1 s-1 at 30 degrees C) suggests that cytochrome c is the electron entry site. Steady-state experiments indicate that cytochrome a has a redox potential higher than cytochrome c. The data from the reaction with O2 reveal a remarkable similarity in the kinetic, equilibrium, and optical properties of caa3 and the electrostatic complex cytochrome c/cytochrome c oxidase. PMID:8662862

  10. Electron transfer kinetics of caa3 oxidase from Bacillus stearothermophilus: a hypothesis for thermophilicity.

    PubMed Central

    Giuffrè, A; Watmough, N J; Giannini, S; Brunori, M; Konings, W N; Greenwood, C

    1999-01-01

    The O2 reaction and the reverse electron transfer of the thermophilic caa3 terminal oxidase of Bacillus stearothermophilus have been studied by laser flash-photolysis. The results show that both reactions, although studied at a temperature of 20 degreesC, far from the optimal temperature of > 60 degreesC for caa3, follow a kinetic behavior essentially identical to that observed with the electrostatic complex between mammalian cyt c and cyt c oxidase. In the O2 reaction cyt a and cyt a3 are very quickly oxidized; cyt a is then re-reduced via CuA, whereas cyt c oxidation is apparently rate-limited by the oxidation of CuA. Upon photodissociation of the mixed valence-CO caa3, reverse electron transfer from the binuclear center to cyt a3+ (tau1 = 3 micros) and CuA2+ (tau2 = 64 micros) is observed, while cyt c is not reduced by any detectable level. These results seem to rule out accounting for enzymatic thermophilicity by altered kinetics of intramolecular electron transfer involving the cyt center in the reduced configuration, which is very fast. On the basis of these results and previous data, we propose that thermophilicity involves an increased activation barrier for the reduction of cyt a3-CuB in the configuration typical of the oxidized site. PMID:9876155

  11. Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases.

    PubMed

    Yang, Shao H; Chang, Sandy Y; Tu, Yiping; Lawson, Gregory W; Bergo, Martin O; Fong, Loren G; Young, Stephen G

    2012-01-01

    Protein farnesyltransferase (FTase) and protein geranylgeranyltransferase-I (GGTase-I) add 15- or 20-carbon lipids, respectively, to proteins that terminate with a CaaX motif. These posttranslational modifications of proteins with lipids promote protein interactions with membrane surfaces in cells, but the in vivo importance of the CaaX prenyltransferases and the protein lipidation reactions they catalyze remain incompletely defined. One study concluded that a deficiency of FTase was inconsequential in adult mice and led to little or no tissue pathology. To assess the physiologic importance of the CaaX prenyltransferases, we used conditional knockout alleles and an albumin-Cre transgene to produce mice lacking FTase, GGTase-I, or both enzymes in hepatocytes. The hepatocyte-specific FTase knockout mice survived but exhibited hepatocellular disease and elevated transaminases. Mice lacking GGTase-I not only had elevated transaminases but also had dilated bile cannaliculi, hyperbilirubinemia, hepatosplenomegaly, and reduced survival. Of note, GGTase-I-deficient hepatocytes had a rounded shape and markedly reduced numbers of actin stress fibers. Hepatocyte-specific FTase/GGTase-I double-knockout mice closely resembled mice lacking GGTase-I alone, but the disease was slightly more severe. Our studies refute the notion that FTase is dispensable and demonstrate that GGTase-I is crucial for the vitality of hepatocytes.

  12. Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases[S

    PubMed Central

    Yang, Shao H.; Chang, Sandy Y.; Tu, Yiping; Lawson, Gregory W.; Bergo, Martin O.; Fong, Loren G.; Young, Stephen G.

    2012-01-01

    Protein farnesyltransferase (FTase) and protein geranylgeranyltransferase-I (GGTase-I) add 15- or 20-carbon lipids, respectively, to proteins that terminate with a CaaX motif. These posttranslational modifications of proteins with lipids promote protein interactions with membrane surfaces in cells, but the in vivo importance of the CaaX prenyltransferases and the protein lipidation reactions they catalyze remain incompletely defined. One study concluded that a deficiency of FTase was inconsequential in adult mice and led to little or no tissue pathology. To assess the physiologic importance of the CaaX prenyltransferases, we used conditional knockout alleles and an albumin–Cre transgene to produce mice lacking FTase, GGTase-I, or both enzymes in hepatocytes. The hepatocyte-specific FTase knockout mice survived but exhibited hepatocellular disease and elevated transaminases. Mice lacking GGTase-I not only had elevated transaminases but also had dilated bile cannaliculi, hyperbilirubinemia, hepatosplenomegaly, and reduced survival. Of note, GGTase-I–deficient hepatocytes had a rounded shape and markedly reduced numbers of actin stress fibers. Hepatocyte-specific FTase/GGTase-I double-knockout mice closely resembled mice lacking GGTase-I alone, but the disease was slightly more severe. Our studies refute the notion that FTase is dispensable and demonstrate that GGTase-I is crucial for the vitality of hepatocytes. PMID:22039581

  13. Title III list of lists: Consolidated list of chemicals subject to the Emergency Planning and Community Right-to-Know Act (EPCRA) and section 112(r) of the Clean Air Act, as amended. Title III of the Superfund Amendments and Reauthorization Act of 1986, and Title III of the Clean Air Act Amendments of 1990

    SciTech Connect

    Not Available

    1994-06-01

    The consolidated chemical list includes chemicals subject to reporting requirements under Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA), also known as the Emergency Planning and Community Right-to-Know Act (EPCRA), and chemicals listed under section 112(r) of Title III the Clean Air Act (CAA) Amendments of 1990. This consolidated list has been prepared to help firms handling chemicals determine whether they need to submit reports under sections 302, 304, or 313 of SARA Title III (EPCRA) and, for a specific chemical, what reports may need to be submitted. Separate lists are also provided of Resource Conservation and Recovery Act (RCRA) waste streams and unlisted hazardous wastes, and of radionuclides reportable under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). These lists should be used as reference tool, not as a definitive source of compliance information. The chemicals on the consolidated list are ordered by Chemical Abstract Service (CAS) registry number. Categories of chemicals, which do not have CAS registry numbers, but which are cited under CERCLA, EPCRA section 313, and the CAA, are placed at the end of the list. More than one chemical name may be listed for one CAS number, because the same chemical may appear on different lists under different names.

  14. 2 CFR 1532.1200 - How will I know if I am disqualified under the CAA or CWA?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... disqualifies you. As a practical matter, you may learn about your disqualification from your defense counsel, a... disqualified under the CAA or CWA? There may be several ways that you learn about your disqualification....

  15. 40 CFR 51.1103 - Application of classification and attainment date provisions in CAA section 181 of subpart 2 to...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... attainment date provisions in CAA section 181 of subpart 2 to areas subject to § 51.1102(a). 51.1103 Section... attainment date provisions in CAA section 181 of subpart 2 to areas subject to § 51.1102(a). (a) In... Ozone NAAQS (0.075 ppm) for Areas Subject to Section 51.1102(a) Area class 8-hour design value(ppm...

  16. 40 CFR 51.1103 - Application of classification and attainment date provisions in CAA section 181 of subpart 2 to...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... attainment date provisions in CAA section 181 of subpart 2 to areas subject to § 51.1102(a). 51.1103 Section... attainment date provisions in CAA section 181 of subpart 2 to areas subject to § 51.1102(a). (a) In... Ozone NAAQS (0.075 ppm) for Areas Subject to Section 51.1102(a) Area class 8-hour design value(ppm...

  17. 40 CFR 51.1103 - Application of classification and attainment date provisions in CAA section 181 of subpart 2 to...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... attainment date provisions in CAA section 181 of subpart 2 to areas subject to § 51.1102(a). 51.1103 Section... attainment date provisions in CAA section 181 of subpart 2 to areas subject to § 51.1102(a). (a) In... Ozone NAAQS (0.075 ppm) for Areas Subject to Section 51.1102(a) Area class 8-hour design value(ppm...

  18. 20 CFR 652.211 - What are State planning requirements under the Act?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... of services provided under the Act in accordance with WIA regulations at 20 CFR 661.220. The State..., DEPARTMENT OF LABOR ESTABLISHMENT AND FUNCTIONING OF STATE EMPLOYMENT SERVICES Wagner-Peyser Act Services...

  19. 20 CFR 652.211 - What are State planning requirements under the Act?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... of services provided under the Act in accordance with WIA regulations at 20 CFR 661.220. The State..., DEPARTMENT OF LABOR ESTABLISHMENT AND FUNCTIONING OF STATE EMPLOYMENT SERVICES Wagner-Peyser Act Services...

  20. 78 FR 4725 - Escrow Requirements Under the Truth in Lending Act (Regulation Z)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ... persons excluded from coverage by section 1029 of the Dodd-Frank Act). See 76 FR 79768 (Dec. 22, 2011... granted to the Board by the Home Ownership and Equity Protection Act of 1994 (HOEPA). See 73 FR 44522... of sections 1461 and 1462 of the Dodd-Frank Act. 76 FR 11598 (Mar. 2, 2011) (the Board's 2011...

  1. Consequences of proposed changes to Clean Water Act thermal discharge requirements

    SciTech Connect

    Veil, J.A.; Moses, D.O.

    1995-12-31

    This paper summarizes three studies that examined the economic and environmental impact on the power industry of (1) limiting thermal mixing zones to 1,000 feet, and (2) eliminating the Clean Water Act (CWA) {section}316(1) variance. Both of these proposed changes were included in S. 1081, a 1991 Senate bill to reauthorize the CWA. The bill would not have provided for grandfathering plants already using the variance or mixing zones larger than 1000 feet. Each of the two changes to the existing thermal discharge requirements were independently evaluated. Power companies were asked what they would do if these two changes were imposed. Most plants affected by the proposed changes would retrofit cooling towers and some would retrofit diffusers. Assuming that all affected plants would proportionally follow the same options as the surveyed plants, the estimated capital cost of retrofitting cooling towers or diffusers at all affected plants ranges from $21.4 to 24.4 billion. Both cooling towers and diffusers exert a 1%-5.8% energy penalty on a plant`s output. Consequently, the power companies must generate additional power if they install those technologies. The estimated cost of the additional power ranges from $10 to 18.4 billion over 20 years. Generation of the extra power would emit over 8 million tons per year of additional carbon dioxide. Operation of the new cooling towers would cause more than 1.5 million gallons per minute of additional evaporation. Neither the restricted mixing zone size nor the elimination of the {section}316(1) variance was adopted into law. More recent proposed changes to the Clean Water Act have not included either of these provisions, but in the future, other Congresses might attempt to reintroduce these types of changes.

  2. 45 CFR 1356.40 - Adoption assistance program: Administrative requirements to implement section 473 of the Act.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SERVICES THE ADMINISTRATION ON CHILDREN, YOUTH AND FAMILIES, FOSTER CARE MAINTENANCE PAYMENTS, ADOPTION ASSISTANCE, AND CHILD AND FAMILY SERVICES REQUIREMENTS APPLICABLE TO TITLE IV-E § 1356.40 Adoption assistance... requirements of section 475(3) of the Act and must: (1) Be signed and in effect at the time of or prior to...

  3. 45 CFR 1356.40 - Adoption assistance program: Administrative requirements to implement section 473 of the Act.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... SERVICES THE ADMINISTRATION ON CHILDREN, YOUTH AND FAMILIES, FOSTER CARE MAINTENANCE PAYMENTS, ADOPTION ASSISTANCE, AND CHILD AND FAMILY SERVICES REQUIREMENTS APPLICABLE TO TITLE IV-E § 1356.40 Adoption assistance... requirements of section 475(3) of the Act and must: (1) Be signed and in effect at the time of or prior to...

  4. 45 CFR 1356.40 - Adoption assistance program: Administrative requirements to implement section 473 of the Act.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SERVICES THE ADMINISTRATION ON CHILDREN, YOUTH AND FAMILIES, FOSTER CARE MAINTENANCE PAYMENTS, ADOPTION ASSISTANCE, AND CHILD AND FAMILY SERVICES REQUIREMENTS APPLICABLE TO TITLE IV-E § 1356.40 Adoption assistance... requirements of section 475(3) of the Act and must: (1) Be signed and in effect at the time of or prior to...

  5. 77 FR 46759 - Proposed Consent Decree, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-06

    ... CAA SIPs for improving visibility in mandatory Federal Class I areas. 74 FR 2392. Plaintiffs filed a... in accordance with section 113(g) of the CAA. 76 FR 75544 (Dec. 2, 2011). Following its review of the... haze. 77 FR 31240 (May 25, 2012). The proposed consent decree requires EPA to sign for publication...

  6. Intergovernmental relations inherent in the Energy Management Partnership Act: a workshop on information requirements

    SciTech Connect

    Hoop, W.J.; Edelson, E.

    1980-02-01

    This paper summarizes the results of the first of three workshops that were planned to assess the information needed by the Office of Conservation and Solar Energy (CS) to effectively evaluate the pending Energy Management Partnership Act (EMPA); the workshop concentrated on issues of the EMPA hierarchical partnership. The approach utilized offers two major benefits to CS. First, by considering the problem of program evaluation while EMPA is still in the planning stage, this study identifies any baseline information that should be collected prior to implementation of EMPA, and also provides CS with the opportunity to include evaluation considerations in the operating guidelines for the program. Second, by identifying the potential problems and benefits inherent in EMPA and then identifying the information necessary to evaluate these problems and benefits, information requirements tied to the reasons for needing that information are generated, rather than a long unrelated laundry list of information requirements. Drafting of EMPA is not yet complete. When the term EMPA is used here, it refers to a set of bills that are presently being melded together. The original EMPA bill, which originated in DOE, was designed to expand the role of state and local governments in achieving national energy goals. Specifically, EMPA would provide a total of $110 million annually to state and local governments over a five year period to (1) develop an overall state energy plan, (2) consolidate three existing federal energy grant programs, (3) allow the secretary to fund directly innovative projects at the local level, and (4) provide additional assistance to states to cover the administrative costs of existing energy programs. Other bills, which may be passed in conjuncttion with EMPA or incorporated into EMPA, place additional emphasis on the local level by allocating as much as $400 million annually to local governments.

  7. Integrating NEPA (National Environmental Policy Act) and CERCLA (Comprehensive Environmental Response, Compensation, and Liability Act) requirements during remedial responses at DOE facilities

    SciTech Connect

    Levine, M.B.; Smith, E.D.; Sharples, F.E.; Eddlemon, G.K.

    1990-07-01

    US Department of Energy (DOE) Order 5400.4, issued October 6, 1989, calls for integrating the requirements of the National Environmental Policy Act (NEPA) with those of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) for DOE remedial actions under CERCLA. CERCLA requires that decisions on site remediation be made through a formal process called a Remedial Investigation/Feasibility Study (RI/FS). According to the DOE order, integration is to be accomplished by conducting the NEPA and CERCLA environmental planning and review procedures concurrently. The primary instrument for integrating the processes is to be the RI/FS process, which will be supplemented as needed to meet the procedural and documentational requirements of NEPA. The final product of the integrated process will be a single, integrated set of documents; namely, an RI report and an FS-EIS that satisfy the requirements of both NEPA and CERCLA. The contents of the report include (1) an overview and comparison of the requirements of the two processes; (2) descriptions of the major tasks included in the integrated RI/FS-EIS process; (3) recommended contents for integrated RI/FS-EIS documents; and (4)a discussion of some potential problems in integrating NEPA and CERCLA that fall outisde the scope of the RI/FS-EIS process, with suggestions for resolving some of these problems. 15 refs.

  8. MEETING THE REQUIREMENTS OF THE U.S. SAFE DRINKING WATER ACT: THE ROLE OF TECHNOLOGY

    EPA Science Inventory

    The passage of the U.S. Safe Drinking Water Act (SDWA) in 1974 has had a major impact on the way water is treated and delivered in the United States. The Act established national drinking water regulations for more than 170,000 public drinking water systems serving over 250 mill...

  9. Relationship of cytochrome caa sub 3 from Thermus thermophilus to other heme- and copper-containing terminal oxidases

    SciTech Connect

    Mather, M.W.; Springer, P.; Fee, J.A.

    1990-01-01

    Cytochrome oxidases are a key component of the energy metabolism of most aerobic organisms from mammals to bacteria. They are the final enzyme of the membrane associated respiratory chain responsible for converting the chemical energy of reduced substrates to a transmembrane electrochemical potential, which issused by the cell for a wide variety of energy-requiring processes. The most widely studied oxidase is the cytochrome c oxidase of the mammalian mitochondrion. This complex, integral membrane protein contains 13 subunits and four canonical metal centers: heme center a and a{sub 3}; copper centers CU{sub A} and CU{sub B}. It is responsible for electron transfer from reduced chytochrome c to dioxygen with the concomitant reduction of dioxygen to water and the coupled vectorial transfer of protons across the mitochondrial membrane. In this communication we will describe preliminary results of DNA sequencing experiments with the cytochrome caa{sub 3} oxidase, initially undertaken to determine the nature of the subunits of this oxidase and shed light on the distribution of the metal centers. We will speculate on oxidase gene and protein structures and evolutionary relationships in the light of these results and recent sequencing results from other groups. 47 refs., 4 figs., 1 tab.

  10. Least-Squares Spectral Element Solutions to the CAA Workshop Benchmark Problems

    NASA Technical Reports Server (NTRS)

    Lin, Wen H.; Chan, Daniel C.

    1997-01-01

    This paper presents computed results for some of the CAA benchmark problems via the acoustic solver developed at Rocketdyne CFD Technology Center under the corporate agreement between Boeing North American, Inc. and NASA for the Aerospace Industry Technology Program. The calculations are considered as benchmark testing of the functionality, accuracy, and performance of the solver. Results of these computations demonstrate that the solver is capable of solving the propagation of aeroacoustic signals. Testing of sound generation and on more realistic problems is now pursued for the industrial applications of this solver. Numerical calculations were performed for the second problem of Category 1 of the current workshop problems for an acoustic pulse scattered from a rigid circular cylinder, and for two of the first CAA workshop problems, i. e., the first problem of Category 1 for the propagation of a linear wave and the first problem of Category 4 for an acoustic pulse reflected from a rigid wall in a uniform flow of Mach 0.5. The aim for including the last two problems in this workshop is to test the effectiveness of some boundary conditions set up in the solver. Numerical results of the last two benchmark problems have been compared with their corresponding exact solutions and the comparisons are excellent. This demonstrates the high fidelity of the solver in handling wave propagation problems. This feature lends the method quite attractive in developing a computational acoustic solver for calculating the aero/hydrodynamic noise in a violent flow environment.

  11. Maintaining Student Records and Meeting Confidentiality Requirements under the Family Education Rights and Privacy Act (FERPA), Individuals with Disability Education Act (IDEA), Section 504 of the Rehabilitation Act (504). A Primer for Educators

    ERIC Educational Resources Information Center

    Copenhaver, John

    2006-01-01

    An important federal statute impacting student records is the Family Educational Rights and Privacy Act (FERPA), enacted to ensure student/parent access to education records and to limit disclosures to others for unauthorized purposes. FERPA Regulations set forth the basic federal records retention and destruction requirements. The records of…

  12. 12 CFR 335.601 - Requirements of section 16 of the Securities Exchange Act of 1934.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... regulations issued under section 16 of the Exchange Act (17 CFR part 240), except that the forms described in... FDICconnect at https://www2.fdicconnect.gov/index.asp. Copies of FDIC Forms 3, 4, and 5 and the...

  13. 12 CFR 335.601 - Requirements of section 16 of the Securities Exchange Act of 1934.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... regulations issued under section 16 of the Exchange Act (17 CFR part 240), except that the forms described in... FDICconnect at https://www2.fdicconnect.gov/index.asp. Copies of FDIC Forms 3, 4, and 5 and the...

  14. 12 CFR 335.601 - Requirements of section 16 of the Securities Exchange Act of 1934.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... regulations issued under section 16 of the Exchange Act (17 CFR part 240), except that the forms described in... FDICconnect at https://www2.fdicconnect.gov/index.asp. Copies of FDIC Forms 3, 4, and 5 and the...

  15. 12 CFR 335.601 - Requirements of section 16 of the Securities Exchange Act of 1934.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... regulations issued under section 16 of the Exchange Act (17 CFR part 240), except that the forms described in... FDICconnect at https://www2.fdicconnect.gov/index.asp. Copies of FDIC Forms 3, 4, and 5 and the...

  16. 16 CFR 500.3 - Prohibited acts, coverage, general labeling requirements, exemption procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... the Act, shall bear a label specifying the identity of the commodity; the name and place of business... initiative or pursuant to petition filed with the Secretary by any interested person or group...

  17. 16 CFR 500.3 - Prohibited acts, coverage, general labeling requirements, exemption procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... the Act, shall bear a label specifying the identity of the commodity; the name and place of business... initiative or pursuant to petition filed with the Secretary by any interested person or group...

  18. 16 CFR 500.3 - Prohibited acts, coverage, general labeling requirements, exemption procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... the Act, shall bear a label specifying the identity of the commodity; the name and place of business... initiative or pursuant to petition filed with the Secretary by any interested person or group...

  19. Clean Air Act: Senate mulls revision bill

    SciTech Connect

    Fairley, P.

    1995-12-13

    Senator Lauch Faircloth (R., NC) has circulated a draft summary of possible revisions of the Clean Air Act (CAA). Chemical industry sources say the proposal would provide some regulatory relief but fear that supporting Faircloth could jeopardize their relationship with EPA. Faircloth`s proposal addresses various controversial aspect of CAA`s Title V permit program including the monitoring and permit modification provisions. The proposal would also define a facility`s {open_quotes}potential to emit,{close_quotes} upon which Title V permits are based. In the past year EPA has substantially revised its Title V program to address complaints from industry, the states, and Congress that the monitoring and modification provisions were too burdensome.

  20. 21 CFR 21.70 - Disclosure and intra-agency use of records in Privacy Act Record Systems; no accounting required.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Privacy Act Record Systems; no accounting required. 21.70 Section 21.70 Food and Drugs FOOD AND DRUG... Privacy Act Record Systems to Persons Other Than the Subject Individual § 21.70 Disclosure and intra-agency use of records in Privacy Act Record Systems; no accounting required. (a) A record about...

  1. 77 FR 33635 - Amendment to the Bank Secrecy Act Regulations-Requirement That Clerks of Court Report Certain...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-07

    ...\\ 66 FR 67680 (December 31, 2001), codified at 31 CFR 1010.330. \\7\\ 26 CFR 1.6050I-1. As amended... Financial Crimes Enforcement Network 31 CFR Part 1010 RIN 1506-AB17 Amendment to the Bank Secrecy Act Regulations--Requirement That Clerks of Court Report Certain Currency Transactions AGENCY: Financial...

  2. Free Appropriate Public Education for Students with Disabilities: Requirements under Section 504 of the "Rehabilitation Act of 1973." Revised

    ERIC Educational Resources Information Center

    US Department of Education, 2007

    2007-01-01

    Section 504 of the "Rehabilitation Act of 1973" protects the rights of individuals with disabilities in programs and activities that receive federal funds. The Section 504 regulation requires a school district to provide a "free appropriate public education" (FAPE) to each qualified person with a disability who is in the school district's…

  3. 48 CFR 52.225-12 - Notice of Buy American Act Requirement-Construction Materials Under Trade Agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Requirement-Construction Materials Under Trade Agreements. 52.225-12 Section 52.225-12 Federal Acquisition...—Construction Materials Under Trade Agreements. As prescribed in 25.1102(d)(1), insert the following provision: Notice of Buy American Act Requirement—Construction Materials Under Trade Agreements (FEB 2009)...

  4. 48 CFR 52.225-12 - Notice of Buy American Act Requirement-Construction Materials Under Trade Agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Requirement-Construction Materials Under Trade Agreements. 52.225-12 Section 52.225-12 Federal Acquisition...—Construction Materials Under Trade Agreements. As prescribed in 25.1102(d)(1), insert the following provision: Notice of Buy American Act Requirement—Construction Materials Under Trade Agreements (FEB 2009)...

  5. 48 CFR 52.225-12 - Notice of Buy American Act Requirement-Construction Materials Under Trade Agreements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Requirement-Construction Materials Under Trade Agreements. 52.225-12 Section 52.225-12 Federal Acquisition...—Construction Materials Under Trade Agreements. As prescribed in 25.1102(d)(1), insert the following provision: Notice of Buy American Act Requirement—Construction Materials Under Trade Agreements (FEB 2009)...

  6. 48 CFR 52.225-12 - Notice of Buy American Act Requirement-Construction Materials Under Trade Agreements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Requirement-Construction Materials Under Trade Agreements. 52.225-12 Section 52.225-12 Federal Acquisition...—Construction Materials Under Trade Agreements. As prescribed in 25.1102(d)(1), insert the following provision: Notice of Buy American Act Requirement—Construction Materials Under Trade Agreements (FEB 2009)...

  7. 2 CFR 176.190 - Award term-Wage rate requirements under Section 1606 of the Recovery Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Award term-Wage rate requirements under Section 1606 of the Recovery Act. 176.190 Section 176.190 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved AWARD TERMS...

  8. 40 CFR 51.903 - How do the classification and attainment date provisions in section 181 of subpart 2 of the CAA...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... attainment date provisions in section 181 of subpart 2 of the CAA apply to areas subject to § 51.902(a)? 51... date provisions in section 181 of subpart 2 of the CAA apply to areas subject to § 51.902(a)? (a) In accordance with section 181(a)(1) of the CAA, each area subject to § 51.902(a) shall be classified...

  9. 40 CFR 51.903 - How do the classification and attainment date provisions in section 181 of subpart 2 of the CAA...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... attainment date provisions in section 181 of subpart 2 of the CAA apply to areas subject to § 51.902(a)? 51... date provisions in section 181 of subpart 2 of the CAA apply to areas subject to § 51.902(a)? (a) In accordance with section 181(a)(1) of the CAA, each area subject to § 51.902(a) shall be classified...

  10. 40 CFR 51.903 - How do the classification and attainment date provisions in section 181 of subpart 2 of the CAA...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... attainment date provisions in section 181 of subpart 2 of the CAA apply to areas subject to § 51.902(a)? 51... date provisions in section 181 of subpart 2 of the CAA apply to areas subject to § 51.902(a)? (a) In accordance with section 181(a)(1) of the CAA, each area subject to § 51.902(a) shall be classified...

  11. 40 CFR 51.903 - How do the classification and attainment date provisions in section 181 of subpart 2 of the CAA...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... attainment date provisions in section 181 of subpart 2 of the CAA apply to areas subject to § 51.902(a)? 51... date provisions in section 181 of subpart 2 of the CAA apply to areas subject to § 51.902(a)? (a) In accordance with section 181(a)(1) of the CAA, each area subject to § 51.902(a) shall be classified...

  12. 40 CFR 51.903 - How do the classification and attainment date provisions in section 181 of subpart 2 of the CAA...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... attainment date provisions in section 181 of subpart 2 of the CAA apply to areas subject to § 51.902(a)? 51... date provisions in section 181 of subpart 2 of the CAA apply to areas subject to § 51.902(a)? (a) In accordance with section 181(a)(1) of the CAA, each area subject to § 51.902(a) shall be classified...

  13. 75 FR 16461 - Proposed Settlement Agreement, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... AGENCY Proposed Settlement Agreement, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency... accordance with section 113(g) of the Clean Air Act, as amended (``CAA'' or ``Act''), 42 U.S.C. 7413(g... title V of the Act, 42 U.S.C. 7661 et seq., to RRI Energy Mid-Atlantic's Portland Generating Station...

  14. Implementation of the Methamphetamine Anti-Proliferation Act; thresholds for retailers and for distributors required to submit mail order reports; changes to mail order reporting requirements. Final rule.

    PubMed

    2003-10-01

    This regulation implements the new threshold requirements and mail order reporting requirements of the Methamphetamine Anti-Proliferation Act of 2000 (MAPA), which was enacted on October 17, 2000. DEA is amending its regulations to reduce the thresholds for pseudoephedrine and phenylpropanolamine for retail distributors and for distributors required to submit mail order reports. Also, DEA is amending its regulations to require mail order reports for certain export transactions. DEA is codifying exemptions from the mail order reporting requirements for certain distributions to nonregulated persons and certain export transactions. This rule is consistent with the intent of MAPA to prevent the diversion of drug products to the clandestine manufacture of methamphetamine and amphetamine, and simultaneously reduce the industry reporting burden. PMID:14535265

  15. Child Labor Requirements in Agriculture under the Fair Labor Standards Act. Child Labor Bulletin No. 102.

    ERIC Educational Resources Information Center

    Employment Standards Administration (DOL), Washington, DC. Wage and Hour Div.

    This booklet is a guide to the provisions of the Fair Labor Standards Act (also known as the Wage-Hour Law) which apply to minors employed in agriculture. The content is as follows: coverage of the child labor provisions regarding agricultural employment, minimum age standards for employment in agriculture, school hours and employment in…

  16. 77 FR 28790 - Medical Loss Ratio Requirements Under the Patient Protection and Affordable Care Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-16

    ... Patient Protection and Affordable Care Act (75 FR 34538) published on June 17, 2010, it was estimated that... on May 5, 2010 (75 FR 24470) relating to the Federal health care reform insurance Web Portal... Federal Register on April 14, 2010 (75 FR 19297). On December 1, 2010, the Department of Health and...

  17. 17 CFR 23.440 - Requirements for swap dealers acting as advisors to Special Entities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... the swap dealer recommends a swap or trading strategy involving a swap that is tailored to the particular needs or characteristics of the Special Entity. (b) Safe harbors. A swap dealer will not “act as... evaluated by a fiduciary before the transaction occurs; or (B) That any recommendation the Special...

  18. 78 FR 6056 - Designation of Payor as Agent To Perform Acts Required of an Employer

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ... Federal Unemployment Tax Act (FUTA) taxes under section 3301. Instead of FICA taxes, railroad employers... employer pays that are subject to FUTA tax are reported annually on Form 940, Employer's Annual Federal Unemployment Tax (FUTA) Return. Employers that pay compensation subject to the RRTA file Form CT-1,...

  19. 7 CFR 3575.40 - Equal opportunity and Fair Housing Act requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Marketing Plan and compliance with the Housing and Urban Development accessibility guidelines except for... Federal Reserve Board Regulation, 12 CFR part 202.) (b) Fair Housing Act. Certain housing-related projects... seq.). The lender will determine that the borrower has a valid plan in effect at all times....

  20. 76 FR 76573 - Medical Loss Ratio Requirements Under the Patient Protection and Affordable Care Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-07

    ... group markets. DATES: Effective date. This rule is effective on January 3, 2012. Comment date. We will... individual markets. A request for information relating to the medical loss ratio (MLR) provisions of PHS Act section 2718 was published in the Federal Register on April 14, 2010 (75 FR 19297). On December 1,...

  1. Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.

    PubMed

    Reid, T Scott; Terry, Kimberly L; Casey, Patrick J; Beese, Lorena S

    2004-10-15

    Post-translational modifications are essential for the proper function of many proteins in the cell. The attachment of an isoprenoid lipid (a process termed prenylation) by protein farnesyltransferase (FTase) or geranylgeranyltransferase type I (GGTase-I) is essential for the function of many signal transduction proteins involved in growth, differentiation, and oncogenesis. FTase and GGTase-I (also called the CaaX prenyltransferases) recognize protein substrates with a C-terminal tetrapeptide recognition motif called the Ca1a2X box. These enzymes possess distinct but overlapping protein substrate specificity that is determined primarily by the sequence identity of the Ca1a2X motif. To determine how the identity of the Ca1a2X motif residues and sequence upstream of this motif affect substrate binding, we have solved crystal structures of FTase and GGTase-I complexed with a total of eight cognate and cross-reactive substrate peptides, including those derived from the C termini of the oncoproteins K-Ras4B, H-Ras and TC21. These structures suggest that all peptide substrates adopt a common binding mode in the FTase and GGTase-I active site. Unexpectedly, while the X residue of the Ca1a2X motif binds in the same location for all GGTase-I substrates, the X residue of FTase substrates can bind in one of two different sites. Together, these structures outline a series of rules that govern substrate peptide selectivity; these rules were utilized to classify known protein substrates of CaaX prenyltransferases and to generate a list of hypothetical substrates within the human genome.

  2. Rocky Flats CAAS System Recalibrated, Retested, and Analyzed to Install in the Criticality Experiments Facility at the Nevada Test Site

    SciTech Connect

    Kim, S; Heinrichs, D; Biswas, D; Huang, S; Dulik, G; Scorby, J; Boussoufi, M; Liu, B; Wilson, R

    2009-05-27

    Neutron detectors and control panels transferred from the Rocky Flats Plant (RFP) were recalibrated and retested for redeployment to the CEF. Testing and calibration were successful with no failure to any equipment. Detector sensitivity was tested at a TRIGA reactor, and the response to thermal neutron flux was satisfactory. MCNP calculated minimum fission yield ({approx} 2 x 10{sup 15} fissions) was applied to determine the thermal flux at selected detector positions at the CEF. Thermal flux levels were greater than 6.39 x 10{sup 6} (n/cm{sup 2}-sec), which was about four orders of magnitude greater than the minimum alarm flux. Calculations of detector survivable distances indicate that, to be out of lethal area, a detector needs to be placed greater than 15 ft away from a maximum credible source. MCNP calculated flux/dose results were independently verified by COG. CAAS calibration and the testing confirmed that the RFP CAAS system is performing its functions as expected. New criteria for the CAAS detector placement and 12-rad zone boundaries at the CEF are established. All of the CAAS related documents and hardware have been transferred from LLNL to NSTec for installation at the CEF high bay areas.

  3. 40 CFR 51.902 - Which classification and nonattainment area planning provisions of the CAA shall apply to areas...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... area planning provisions of the CAA shall apply to areas designated nonattainment for the 1997 8-hour NAAQS? 51.902 Section 51.902 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Implementation of 8-hour Ozone National Ambient Air Quality Standard § 51.902 Which classification...

  4. 40 CFR 51.902 - Which classification and nonattainment area planning provisions of the CAA shall apply to areas...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... area planning provisions of the CAA shall apply to areas designated nonattainment for the 1997 8-hour NAAQS? 51.902 Section 51.902 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Implementation of 8-hour Ozone National Ambient Air Quality Standard § 51.902 Which classification...

  5. 40 CFR 51.902 - Which classification and nonattainment area planning provisions of the CAA shall apply to areas...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Implementation of 8-hour Ozone National Ambient Air Quality Standard § 51.902 Which classification and... with a 1-hour ozone design value equal to or greater than 0.121 ppm at the time the Administrator signs...) Covered under subpart 1 (CAA). An area designated nonattainment for the 8-hour ozone NAAQS with a...

  6. 40 CFR 51.902 - Which classification and nonattainment area planning provisions of the CAA shall apply to areas...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Implementation of 8-hour Ozone National Ambient Air Quality Standard § 51.902 Which classification and... with a 1-hour ozone design value equal to or greater than 0.121 ppm at the time the Administrator signs...) Covered under subpart 1 (CAA). An area designated nonattainment for the 8-hour ozone NAAQS with a...

  7. 40 CFR 62.14480 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act and...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... an operating permit under title V of the Clean Air Act and implementing regulations? 62.14480 Section... the Clean Air Act and implementing regulations? This subpart requires you to obtain an operating permit under title V of the Clean Air Act and implementing regulations (“title V permit”) unless you...

  8. 40 CFR 62.14480 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act and...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... an operating permit under title V of the Clean Air Act and implementing regulations? 62.14480 Section... the Clean Air Act and implementing regulations? This subpart requires you to obtain an operating permit under title V of the Clean Air Act and implementing regulations (“title V permit”) unless you...

  9. 36 CFR 801.6 - Coordination with requirements under the National Environmental Policy Act (42 U.S.C. 4321 et seq.).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... underway and the final EIS should reflect the results of this process. Applicants are directed to 36 CFR... requirements under the National Environmental Policy Act (42 U.S.C. 4321 et seq.). 801.6 Section 801.6 Parks... National Environmental Policy Act (42 U.S.C. 4321 et seq.). The National Historic Preservation Act and...

  10. 36 CFR 801.6 - Coordination with requirements under the National Environmental Policy Act (42 U.S.C. 4321 et seq.).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... underway and the final EIS should reflect the results of this process. Applicants are directed to 36 CFR... requirements under the National Environmental Policy Act (42 U.S.C. 4321 et seq.). 801.6 Section 801.6 Parks... National Environmental Policy Act (42 U.S.C. 4321 et seq.). The National Historic Preservation Act and...

  11. 36 CFR 801.6 - Coordination with requirements under the National Environmental Policy Act (42 U.S.C. 4321 et seq.).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... underway and the final EIS should reflect the results of this process. Applicants are directed to 36 CFR... requirements under the National Environmental Policy Act (42 U.S.C. 4321 et seq.). 801.6 Section 801.6 Parks... National Environmental Policy Act (42 U.S.C. 4321 et seq.). The National Historic Preservation Act and...

  12. 36 CFR 801.6 - Coordination with requirements under the National Environmental Policy Act (42 U.S.C. 4321 et seq.).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... underway and the final EIS should reflect the results of this process. Applicants are directed to 36 CFR... requirements under the National Environmental Policy Act (42 U.S.C. 4321 et seq.). 801.6 Section 801.6 Parks... National Environmental Policy Act (42 U.S.C. 4321 et seq.). The National Historic Preservation Act and...

  13. 78 FR 48161 - Proposed Consent Decree, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-07

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed Consent Decree, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency (EPA... section 113(g) of the Clean Air Act, as amended (CAA or the Act), notice is hereby given of a...

  14. 76 FR 45793 - Proposed Settlement Agreement, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-01

    ... From the Federal Register Online via the Government Publishing Office ] ENVIRONMENTAL PROTECTION AGENCY Proposed Settlement Agreement, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency... accordance with section 113(g) of the Clean Air Act, as amended (``CAA'' or the ``Act''), 42 U.S.C....

  15. 75 FR 67719 - Proposed Consent Decree, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-03

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed Consent Decree, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency... section 113(g) of the Clean Air Act, as amended (CAA or the Act), 42 U.S.C. 7413(g), notice is...

  16. 76 FR 51030 - Proposed Consent Decree, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed Consent Decree, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency (EPA... section 113(g) of the Clean Air Act, as amended (``CAA'' or the ``Act''), 42 U.S.C. 7413(g), notice...

  17. 76 FR 81930 - Proposed Settlement Agreement, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-29

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed Settlement Agreement, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency... accordance with section 113(g) of the Clean Air Act, as amended (``CAA'' or the ``Act''), notice is...

  18. 78 FR 40140 - Proposed Consent Decree, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed Consent Decree, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency (EPA... section 113(g) of the Clean Air Act, as amended (``CAA'' or the ``Act''), notice is hereby given of...

  19. 75 FR 22786 - Proposed Consent Decree, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed Consent Decree, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency (EPA... section 113(g) of the Clean Air Act, as amended (``CAA'' or the ``Act''), 42 U.S.C. 7413(g), notice...

  20. 78 FR 43200 - Proposed Settlement Agreement, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-19

    ... 1997 8-hour ozone national ambient air quality standard in the South Coast. 77 FR 12674 (March 1, 2012... AGENCY Proposed Settlement Agreement, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency... accordance with section 113(g) of the Clean Air Act, as amended (``CAA'' or the ``Act''), notice is...

  1. 76 FR 75544 - Proposed Consent Decree, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-02

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed Consent Decree, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency (EPA... section 113(g) of the Clean Air Act, as amended (``CAA'' or the ``Act''), 42 U.S.C. 7413(g), notice...

  2. 76 FR 75545 - Proposed Consent Decree, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-02

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed Consent Decree, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency (EPA... section 113(g) of the Clean Air Act, as amended (``CAA'' or the ``Act''), 42 U.S.C. 7413(g), notice...

  3. 78 FR 53143 - Proposed Consent Decree, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-28

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed Consent Decree, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency (EPA... section 113(g) of the Clean Air Act, as amended (``CAA'' or the ``Act''), notice is hereby given of...

  4. 77 FR 56840 - Proposed Consent Decree, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed Consent Decree, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency (EPA... section 113(g) of the Clean Air Act, as amended (``CAA'' or the ``Act''), 42 U.S.C. 7413(g), notice...

  5. 77 FR 67814 - Proposed Settlement Agreement, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-14

    ... Pollution Affecting Visibility and Best Available Retrofit Technology Determinations,'' 76 FR 81,728 (Dec... AGENCY Proposed Settlement Agreement, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency... accordance with section 113(g) of the Clean Air Act, as amended (``CAA'' or the ``Act''), notice is...

  6. 41 CFR 301-10.137 - What exceptions to the Fly America Act requirements apply when I travel solely outside the United...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 4 2011-07-01 2011-07-01 false What exceptions to the Fly America Act requirements apply when I travel solely outside the United States, and a U.S. flag air... Air Carriers § 301-10.137 What exceptions to the Fly America Act requirements apply when I...

  7. 41 CFR 301-10.137 - What exceptions to the Fly America Act requirements apply when I travel solely outside the United...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What exceptions to the Fly America Act requirements apply when I travel solely outside the United States, and a U.S. flag air... Air Carriers § 301-10.137 What exceptions to the Fly America Act requirements apply when I...

  8. 48 CFR 52.225-24 - Notice of Required Use of American Iron, Steel, and Manufactured Goods-Buy American Act...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... American Iron, Steel, and Manufactured Goods-Buy American Act-Construction Materials Under Trade Agreements....225-24 Notice of Required Use of American Iron, Steel, and Manufactured Goods—Buy American Act...: Notice of Required Use of American Iron, Steel, and Manufactured Goods—Buy American...

  9. 48 CFR 52.225-24 - Notice of Required Use of American Iron, Steel, and Manufactured Goods-Buy American Act...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... American Iron, Steel, and Manufactured Goods-Buy American Act-Construction Materials Under Trade Agreements....225-24 Notice of Required Use of American Iron, Steel, and Manufactured Goods—Buy American Act...: Notice of Required Use of American Iron, Steel, and Manufactured Goods—Buy American...

  10. 40 CFR 62.15395 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 9 2014-07-01 2014-07-01 false Does this subpart require me to obtain an operating permit under title V of the Clean Air Act? 62.15395 Section 62.15395 Protection of... require me to obtain an operating permit under title V of the Clean Air Act? Yes. If you are subject...

  11. 40 CFR 62.15395 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 9 2013-07-01 2013-07-01 false Does this subpart require me to obtain an operating permit under title V of the Clean Air Act? 62.15395 Section 62.15395 Protection of... require me to obtain an operating permit under title V of the Clean Air Act? Yes. If you are subject...

  12. 40 CFR 62.15395 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 9 2012-07-01 2012-07-01 false Does this subpart require me to obtain an operating permit under title V of the Clean Air Act? 62.15395 Section 62.15395 Protection of... require me to obtain an operating permit under title V of the Clean Air Act? Yes. If you are subject...

  13. 40 CFR 62.15395 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 8 2011-07-01 2011-07-01 false Does this subpart require me to obtain an operating permit under title V of the Clean Air Act? 62.15395 Section 62.15395 Protection of... require me to obtain an operating permit under title V of the Clean Air Act? Yes. If you are subject...

  14. 41 CFR 301-10.137 - What exceptions to the Fly America Act requirements apply when I travel solely outside the United...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 4 2014-07-01 2014-07-01 false What exceptions to the Fly America Act requirements apply when I travel solely outside the United States, and a U.S. flag air... Air Carriers § 301-10.137 What exceptions to the Fly America Act requirements apply when I...

  15. 48 CFR 52.225-24 - Notice of Required Use of American Iron, Steel, and Manufactured Goods-Buy American Act...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... American Iron, Steel, and Manufactured Goods-Buy American Act-Construction Materials Under Trade Agreements....225-24 Notice of Required Use of American Iron, Steel, and Manufactured Goods—Buy American Act...: Notice of Required Use of American Iron, Steel, and Manufactured Goods—Buy American...

  16. 48 CFR 52.225-24 - Notice of Required Use of American Iron, Steel, and Manufactured Goods-Buy American Act...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... American Iron, Steel, and Manufactured Goods-Buy American Act-Construction Materials Under Trade Agreements....225-24 Notice of Required Use of American Iron, Steel, and Manufactured Goods—Buy American Act...: Notice of Required Use of American Iron, Steel, and Manufactured Goods—Buy American...

  17. 40 CFR 62.15395 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 8 2010-07-01 2010-07-01 false Does this subpart require me to obtain an operating permit under title V of the Clean Air Act? 62.15395 Section 62.15395 Protection of... require me to obtain an operating permit under title V of the Clean Air Act? Yes. If you are subject...

  18. 25 CFR 30.102 - Does the Act require the Secretary of the Interior to develop a definition of AYP for Bureau...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... develop a definition of AYP for Bureau-funded schools? 30.102 Section 30.102 Indians BUREAU OF INDIAN... § 30.102 Does the Act require the Secretary of the Interior to develop a definition of AYP for Bureau-funded schools? Yes, the Act requires the Secretary to develop a definition of AYP through...

  19. 48 CFR 52.204-11 - American Recovery and Reinvestment Act-Reporting Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Text of Provisions and Clauses 52.204-11 American Recovery and Reinvestment Act—Reporting Requirements... Contractor's existing practice for describing jobs as long as the terms used are widely understood and... terms used are widely understood and describe the general nature of the work; and (B) An estimate of...

  20. 48 CFR 952.226-72 - Energy Policy Act subcontracting goals and reporting requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) An institution of higher education that meets the requirements of 34 CFR 600.4(a), and has a student... of Education pursuant to 34 CFR 608.2; and (3) Small business concerns, as defined under section 3 of... Americans, i.e., American Indians, Eskimos, Aleuts, and Native Hawaiians, or any combination thereof;...

  1. 48 CFR 952.226-72 - Energy Policy Act subcontracting goals and reporting requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) An institution of higher education that meets the requirements of 34 CFR 600.4(a), and has a student... of Education pursuant to 34 CFR 608.2; and (3) Small business concerns, as defined under section 3 of... Americans, i.e., American Indians, Eskimos, Aleuts, and Native Hawaiians, or any combination thereof;...

  2. 48 CFR 952.226-72 - Energy Policy Act subcontracting goals and reporting requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) An institution of higher education that meets the requirements of 34 CFR 600.4(a), and has a student... of Education pursuant to 34 CFR 608.2; and (3) Small business concerns, as defined under section 3 of... Americans, i.e., American Indians, Eskimos, Aleuts, and Native Hawaiians, or any combination thereof;...

  3. 48 CFR 952.226-72 - Energy Policy Act subcontracting goals and reporting requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) An institution of higher education that meets the requirements of 34 CFR 600.4(a), and has a student... of Education pursuant to 34 CFR 608.2; and (3) Small business concerns, as defined under section 3 of... Americans, i.e., American Indians, Eskimos, Aleuts, and Native Hawaiians, or any combination thereof;...

  4. Nurse Supply, Distribution and Requirements. 3rd Report to the Congress. Nurse Training Act of 1975.

    ERIC Educational Resources Information Center

    Health Resources Administration (DHHS/PHS), Hyattsville, MD. Div. of Nursing.

    This report focuses on the supply, distribution of, and requirements for nursing. The first chapter describes the supply of registered and licensed practical nurses. Characteristics of the overall nursing supply are discussed in terms of marital status, age, and employment patterns. Data are also provided on nurses newly licensed to practice,…

  5. 48 CFR 952.226-72 - Energy Policy Act subcontracting goals and reporting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) An institution of higher education that meets the requirements of 34 CFR 600.4(a), and has a student... of Education pursuant to 34 CFR 608.2; and (3) Small business concerns, as defined under section 3 of... Mexico, Puerto Rico, Cuba, or Central or South America, or any combination thereof, or (ii)...

  6. A novel cis-acting element required for DNA damage-inducible expression of yeast DIN7

    SciTech Connect

    Yoshitani, Ayako; Yoshida, Minoru; Ling Feng

    2008-01-04

    Din7 is a DNA damage-inducible mitochondrial nuclease that modulates the stability of mitochondrial DNA (mtDNA) in Saccharomyces cerevisiae. How DIN7 gene expression is regulated, however, has remained largely unclear. Using promoter sequence alignment, we found a highly conserved 19-bp sequence in the promoter regions of DIN7 and NTG1, which encodes an oxidative stress-inducible base-excision-repair enzyme. Deletion of the 19-bp sequence markedly reduced the hydroxyurea (HU)-enhanced DIN7 promoter activity. In addition, nuclear fractions prepared from HU-treated cells were used in in vitro band shift assays to reveal the presence of currently unidentified trans-acting factor(s) that preferentially bound to the 19-bp region. These results suggest that the 19-bp sequence is a novel cis-acting element that is required for the regulation of DIN7 expression in response to HU-induced DNA damage.

  7. Structural insights into electron transfer in caa3-type cytochrome oxidase.

    PubMed

    Lyons, Joseph A; Aragão, David; Slattery, Orla; Pisliakov, Andrei V; Soulimane, Tewfik; Caffrey, Martin

    2012-07-26

    Cytochrome c oxidase is a member of the haem copper oxidase superfamily (HCO). HCOs function as the terminal enzymes in the respiratory chain of mitochondria and aerobic prokaryotes, coupling molecular oxygen reduction to transmembrane proton pumping. Integral to the enzyme's function is the transfer of electrons from cytochrome c to the oxidase via a transient association of the two proteins. Electron entry and exit are proposed to occur from the same site on cytochrome c. Here we report the crystal structure of the caa3-type cytochrome oxidase from Thermus thermophilus, which has a covalently tethered cytochrome c domain. Crystals were grown in a bicontinuous mesophase using a synthetic short-chain monoacylglycerol as the hosting lipid. From the electron density map, at 2.36 Å resolution, a novel integral membrane subunit and a native glycoglycerophospholipid embedded in the complex were identified. Contrary to previous electron transfer mechanisms observed for soluble cytochrome c, the structure reveals the architecture of the electron transfer complex for the fused cupredoxin/cytochrome c domain, which implicates different sites on cytochrome c for electron entry and exit. Support for an alternative to the classical proton gate characteristic of this HCO class is presented.

  8. Impacts & Compliance Implementation Plans & Required Deviations for Toxic Substance Control Act (TSCA) Regulation of Double Shell Tanks (DST)

    SciTech Connect

    MULKEY, C.H.

    2000-08-22

    In May 2000, the U.S. Department of Energy, Office of River Protection (DOE-ORP) and the U.S. Environmental Protection Agency (EPA) held meetings regarding the management of polychlorinated biphenyls (PCBs) in the Hanford tank waste. It was decided that the radioactive waste currently stored in the double-shell tanks (DSTs) contain waste which will become subject to the Toxic Substance Control Act (TSCA) (40 CFR 761). As a result, DOE-ORP directed the River Protection Project tank farm contractor (TFC) to prepare plans for managing the PCB inventory in the DSTs. Two components of the PCB management plans are this assessment of the operational impacts of TSCA regulation and the identifications of deviations from TSCA that are required to accommodate tank farm unique limitations. This plan provides ORP and CH2M HILL Hanford Group, Inc. (CHG) with an outline of TSCA PCB requirements and their applicability to tank farm activities, and recommends a compliance/implementation approach. Where strict compliance is not possible, the need for deviations from TSCA PCB requirements is identified. The purpose of assembling this information is to enhance the understanding of PCB management requirements, identify operational impacts and select impact mitigation strategies. This information should be useful in developing formal agreements with EPA where required.

  9. Interactions between late acting proteins required for peptidoglycan synthesis during sporulation

    PubMed Central

    Fay, Allison; Meyer, Pablo; Dworkin, Jonathan

    2010-01-01

    The requirement of peptidoglycan synthesis for growth complicates the analysis of interactions between proteins involved in this pathway. In particular, the later steps that involve membrane-linked substrates have proven largely recalcitrant to in vivo analysis. Here we have taken advantage of the peptidoglycan synthesis that occurs during sporulation in Bacillus subtilis to examine the interactions between SpoVE, a non-essential, sporulation-specific homolog of the well-conserved and essential SEDS proteins, and SpoVD, a non-essential class B penicillin binding protein (PBP). We found that localization of SpoVD is dependent on SpoVE and that SpoVD protects SpoVE from in vivo proteolysis. Co-immunoprecipitations and Fluorescence Resonance Energy Transfer experiments indicated that SpoVE and SpoVD interact and co-affinity purification in E. coli demonstrated that this interaction is direct. Finally, we generated a functional protein consisting of a SpoVE-SpoVD fusion and found that a loss-of-function point mutation in either part of the fusion resulted in a loss of function of the entire fusion that was not complemented by a wild type protein. Thus, SpoVE has a direct and functional interaction with SpoVD and this conclusion will facilitate understanding the essential function SpoVE and related SEDS proteins such as FtsW and RodA play in bacterial growth and division. PMID:20417640

  10. Examination of the Data Requirements of the Workforce Investment Act and the Perkins Act of 1998. Report of the National Postsecondary Education Cooperative Working Group on Workforce Development.

    ERIC Educational Resources Information Center

    Brustein, Michael

    This paper focuses on the data ramification of the Workforce Investment Act (WIA) and the Carl D. Perkins Vocational and Technical Education Act of 1998. Section 1 provides an outline of the role of these postsecondary institutions under WIA: members of the State and local boards; one-stop operators; one-stop partners; and eligible service…

  11. Delineation of Cis-Acting Sequences Required for Expression of Drosophila Mojavensis Adh-1

    PubMed Central

    Bayer, C. A.; Curtiss, S. W.; Weaver, J. A.; Sullivan, D. T.

    1992-01-01

    The control of expression of the Adh-1 gene of Drosophila mojavensis has been analyzed by transforming ADH null Drosophila melanogaster hosts with P element constructs which contain D. mojavensis Adh-1 having deletions of different extent in the 5' and 3' ends. Adh-1 expression in the D. melanogaster hosts is qualitatively similar to expression in D. mojavensis, although expression is quantitatively lower in transformants. Deletions of the 5' end indicate that information required for normal temporal and tissue expression in larvae is contained within 70 bp of the transcription start site. However, deletion constructs to -70 are deficient in ovarian nurse cell expression, whereas the additional upstream sequences present in constructs containing deletions to -257 do support expression in the ovary. Comparison of the nucleotide sequence in the -257 to -70 region of Adh-1 of four species: D. mojavensis and Drosophila arizona, which express Adh-1 in the ovary, and Drosophila mulleri and Drosophila navojoa, which do not, has led to the identification of regions of sequence similarity that correlate with ovary expression. One of these bears a striking similarity to a conserved sequence located upstream of the three heat shock genes that have constitutive ovarian expression and may be an ovarian control element. We have identified an aberrant aspect of Adh-1 expression. In transformants which carry an Adh-1 gene without a functional upstream Adh-2 gene Adh-1 expression continues into the adult stage instead of ceasing at the onset of metamorphosis. In transformants with a functional Adh-2 gene, Adh-1 expression ceases in the third larval instar stage and aberrant expression in the adult stage does not occur. PMID:1317314

  12. 75 FR 17906 - Privacy Act of 1974; Systems of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-08

    ..., 2004; 69 FR 67112). Changes: System identifier: Delete ``CAAS'' from entry. * * * * * System location... of the Secretary Privacy Act of 1974; Systems of Records AGENCY: Defense Logistics Agency, DoD. ACTION: Notice to amend a system of records. SUMMARY: The Defense Logistics Agency proposes to amend...

  13. Ninety-day waiting period limitation and technical amendments to certain health coverage requirements under the Affordable Care Act. Final rule.

    PubMed

    2014-02-24

    These final regulations implement the 90-day waiting period limitation under section 2708 of the Public Health Service Act, as added by the Patient Protection and Affordable Care Act (Affordable Care Act), as amended, and incorporated into the Employee Retirement Income Security Act of 1974 and the Internal Revenue Code. These regulations also finalize amendments to existing regulations to conform to Affordable Care Act provisions. Specifically, these rules amend regulations implementing existing provisions such as some of the portability provisions added by the Health Insurance Portability and Accountability Act of 1996 (HIPAA) because those provisions of the HIPAA regulations have become superseded or require amendment as a result of the market reform protections added by the Affordable Care Act.

  14. 45 CFR 73.735-902 - Reporting requirements for certain employees not covered by the Ethics in Government Act of 1978.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... covered by the Ethics in Government Act of 1978. 73.735-902 Section 73.735-902 Public Welfare Department... Interests § 73.735-902 Reporting requirements for certain employees not covered by the Ethics in Government... Ethics in Government Act except: (i) Doctors, dentists and allied medical specialists performing...

  15. 45 CFR 73.735-902 - Reporting requirements for certain employees not covered by the Ethics in Government Act of 1978.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... covered by the Ethics in Government Act of 1978. 73.735-902 Section 73.735-902 Public Welfare DEPARTMENT... Interests § 73.735-902 Reporting requirements for certain employees not covered by the Ethics in Government... Ethics in Government Act except: (i) Doctors, dentists and allied medical specialists performing...

  16. 45 CFR 73.735-902 - Reporting requirements for certain employees not covered by the Ethics in Government Act of 1978.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... covered by the Ethics in Government Act of 1978. 73.735-902 Section 73.735-902 Public Welfare DEPARTMENT... Interests § 73.735-902 Reporting requirements for certain employees not covered by the Ethics in Government... Ethics in Government Act except: (i) Doctors, dentists and allied medical specialists performing...

  17. 24 CFR 1000.42 - Are the requirements of section 3 of the Housing and Urban Development Act of 1968 applicable?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Development Act of 1968 (12 U.S.C. 1701u) and HUD's implementing regulations in 24 CFR part 135, to the... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Are the requirements of section 3 of the Housing and Urban Development Act of 1968 applicable? 1000.42 Section 1000.42 Housing...

  18. 24 CFR 1000.42 - Are the requirements of section 3 of the Housing and Urban Development Act of 1968 applicable?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Development Act of 1968 (12 U.S.C. 1701u) and HUD's implementing regulations in 24 CFR part 135, to the... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Are the requirements of section 3 of the Housing and Urban Development Act of 1968 applicable? 1000.42 Section 1000.42 Housing...

  19. The Education Requirement of the U.S. Immigration Reform and Control Act of 1986: A Case Study of Ineffective Language Planning.

    ERIC Educational Resources Information Center

    Huss, Susan

    An analysis of the Immigration Reform and Control Act of 1986 (IRCA), which requires basic English language proficiency and knowledge of United States history and civics of illegal aliens seeking permanent residency status, suggests that the Act is an example of poor language planning. The analysis has three components. First, the legalization…

  20. 45 CFR 73.735-902 - Reporting requirements for certain employees not covered by the Ethics in Government Act of 1978.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... covered by the Ethics in Government Act of 1978. 73.735-902 Section 73.735-902 Public Welfare DEPARTMENT... Interests § 73.735-902 Reporting requirements for certain employees not covered by the Ethics in Government Act of 1978. (a) Applicability. The following employees and special Government employees shall...

  1. 21 CFR 21.70 - Disclosure and intra-agency use of records in Privacy Act Record Systems; no accounting required.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Disclosure and intra-agency use of records in Privacy Act Record Systems; no accounting required. 21.70 Section 21.70 Food and Drugs FOOD AND DRUG... Privacy Act Record Systems to Persons Other Than the Subject Individual § 21.70 Disclosure and...

  2. 21 CFR 21.70 - Disclosure and intra-agency use of records in Privacy Act Record Systems; no accounting required.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Disclosure and intra-agency use of records in Privacy Act Record Systems; no accounting required. 21.70 Section 21.70 Food and Drugs FOOD AND DRUG... Privacy Act Record Systems to Persons Other Than the Subject Individual § 21.70 Disclosure and...

  3. 76 FR 43684 - Clean Air Act Operating Permit Program; Petition for Objection to State Operating Permit for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-21

    ... Energy (Xcel)--Pawnee Power Station. Pursuant to section 505(b)(2) of the Clean Air Act (Act or CAA... AGENCY Clean Air Act Operating Permit Program; Petition for Objection to State Operating Permit for Public Service Company of Colorado dba Xcel Energy--Pawnee Power Station AGENCY: Environmental...

  4. The Clean Air Act Amendments of 1990: Hazardous Air Pollutant Requirements and the DOE Clean Coal Technology Program

    SciTech Connect

    Moskowitz, P.D.; DePhillips, M.; Fthenakis, V.M.; Hemenway, A.

    1991-12-31

    The purpose of the US Department of Energy -- Office of Fossil Energy (DOE FE) Clean Coal Technology Program (CCTP) is to provide the US energy marketplace with advanced, efficient, and environmentally sound coal-based technologies. The design, construction, and operation of Clean Coal Technology Demonstration Projects (CCTDP) will generate data needed to make informed, confident decisions on the commercial readiness of these technologies. These data also will provide information needed to ensure a proactive response by DOE and its industrial partners to the establishment of new regulations or a reactive response to existing regulations promulgated by the US Environmental Protection Agency (EPA). The objectives of this paper are to: (1) Present a preliminary examination of the potential implications of the Clean Air Act Amendments (CAAA) -- Title 3 Hazardous Air Pollutant requirements to the commercialization of CCTDP; and (2) help define options available to DOE and its industrial partners to respond to this newly enacted Legislation.

  5. The Clean Air Act Amendments of 1990: Hazardous Air Pollutant Requirements and the DOE Clean Coal Technology Program

    SciTech Connect

    Moskowitz, P.D.; DePhillips, M.; Fthenakis, V.M. ); Hemenway, A. )

    1991-01-01

    The purpose of the US Department of Energy -- Office of Fossil Energy (DOE FE) Clean Coal Technology Program (CCTP) is to provide the US energy marketplace with advanced, efficient, and environmentally sound coal-based technologies. The design, construction, and operation of Clean Coal Technology Demonstration Projects (CCTDP) will generate data needed to make informed, confident decisions on the commercial readiness of these technologies. These data also will provide information needed to ensure a proactive response by DOE and its industrial partners to the establishment of new regulations or a reactive response to existing regulations promulgated by the US Environmental Protection Agency (EPA). The objectives of this paper are to: (1) Present a preliminary examination of the potential implications of the Clean Air Act Amendments (CAAA) -- Title 3 Hazardous Air Pollutant requirements to the commercialization of CCTDP; and (2) help define options available to DOE and its industrial partners to respond to this newly enacted Legislation.

  6. 78 FR 42942 - Clean Water Act Class II: Proposed Administrative Settlement, Penalty Assessment and Opportunity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-18

    ... Emergency Planning and Community Right-to-Know Act (EPCRA), the Clean Air Act (CAA), the Resource... publicly available, e.g., CBI or other information whose disclosure is restricted by statute. Certain other..., Correction and Prevention of Violations (Audit Policy), 65 FR 19618 (Apr. 11, 2000), regarding 88...

  7. 75 FR 74048 - Proposed Consent Decree, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-30

    ... section 113(g) of the Clean Air Act, as amended (``CAA'' or the ``Act''), 42 U.S.C. 7413(g), notice is..., 42 U.S.C. 7410(k)(2), to take action on certain State Implementation Plan (``SIP'') submittals by...

  8. 76 FR 56757 - Proposed Consent Decree, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed Consent Decree, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency (EPA... section 113(g) of the Clean Air Act, as amended (``CAA''), 42 U.S.C. 7413(g), notice is hereby given of...

  9. 78 FR 21419 - Notice of Proposed Consent Decree Under the Clean Air Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Notice of Proposed Consent Decree Under the Clean Air Act On April 4, 2013, the Department of Justice lodged... Processed Meats, Inc. The United States filed this lawsuit under the Clean Air Act (CAA), 42 U.S.C....

  10. 77 FR 39493 - Proposed Consent Decree, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ... AGENCY Proposed Consent Decree, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency (EPA... section 113(g) of the Clean Air Act, as amended (``CAA''), notice is hereby given of a proposed consent... Amended Complaint alleging that EPA failed to perform nondiscretionary duties under the Clean Air...

  11. 75 FR 24946 - Proposed Consent Decree, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-06

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed Consent Decree, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency (EPA... section 113(g) of the Clean Air Act, as amended (``CAA''), 42 U.S.C. 7413(g), notice is hereby given of...

  12. 75 FR 38520 - Proposed Consent Decree, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-02

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed Consent Decree, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency (EPA... section 113(g) of the Clean Air Act, as amended (CAA), 42 U.S.C. 7413(g), notice is hereby given of...

  13. 75 FR 9208 - Proposed Consent Decree, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-01

    ... AGENCY Proposed Consent Decree, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency (EPA... section 113(g) of the Clean Air Act, as amended (``CAA''), 42 U.S.C. 7413(g), notice is hereby given of a... Waterkeeper, Inc., Clean Water Action, and Chesapeake Climate Action Network (collectively ``Plaintiffs'')...

  14. 77 FR 65684 - Proposed Consent Decree, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-30

    ... AGENCY Proposed Consent Decree, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency (EPA... section 113(g) of the Clean Air Act, as amended (``CAA''), notice is hereby given of a proposed consent... Amended Complaint alleging that EPA failed to perform nondiscretionary duties under the Clean Air...

  15. 77 FR 46757 - Proposed Consent Decree, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-06

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed Consent Decree, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency (EPA... section 113(g) of the Clean Air Act, as amended (``CAA''), notice is hereby given of a proposed...

  16. 77 FR 66978 - Proposed Consent Decree, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-08

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed Consent Decree, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency (EPA... section 113(g) of the Clean Air Act, as amended (``CAA''), notice is hereby given of a proposed...

  17. 75 FR 38519 - Proposed Consent Decree, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-02

    ... From the Federal Register Online via the Government Publishing Office ] ENVIRONMENTAL PROTECTION AGENCY Proposed Consent Decree, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency (EPA... section 113(g) of the Clean Air Act, as amended (CAA), 42 U.S.C. 7413(g), notice is hereby given of...

  18. 76 FR 58808 - Proposed Consent Decree, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-22

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed Consent Decree, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency (EPA... section 113(g) of the Clean Air Act, as amended (``CAA''), 42 U.S.C. 7413(g), notice is hereby given of...

  19. 49 CFR Appendix A to Part 228 - Requirements of the Hours of Service Act: Statement of Agency Policy and Interpretation

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... event than an “unavoidable accident or Act of God” under section 5(d) of the Act. Example: The crew of a... wreck crew re-rails or clears the last car and the maintenance of way department releases the track to... of his duties as a trainman. Casualties, Unavoidable Accidents, Acts of God. Section 5(d) of the...

  20. 40 CFR 62.14480 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act and...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Permitting Obligation § 62.14480 Does this subpart require me to obtain an operating permit under title V of... 40 Protection of Environment 9 2013-07-01 2013-07-01 false Does this subpart require me to obtain an operating permit under title V of the Clean Air Act and implementing regulations? 62.14480...

  1. 40 CFR 62.14480 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act and...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Permitting Obligation § 62.14480 Does this subpart require me to obtain an operating permit under title V of... 40 Protection of Environment 9 2014-07-01 2014-07-01 false Does this subpart require me to obtain an operating permit under title V of the Clean Air Act and implementing regulations? 62.14480...

  2. 40 CFR 62.14480 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act and...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Permitting Obligation § 62.14480 Does this subpart require me to obtain an operating permit under title V of... 40 Protection of Environment 9 2012-07-01 2012-07-01 false Does this subpart require me to obtain an operating permit under title V of the Clean Air Act and implementing regulations? 62.14480...

  3. 48 CFR 52.225-22 - Notice of Required Use of American Iron, Steel, and Manufactured Goods-Buy American Act...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... American Iron, Steel, and Manufactured Goods-Buy American Act-Construction Materials. 52.225-22 Section 52... Required Use of American Iron, Steel, and Manufactured Goods—Buy American Act—Construction Materials. As prescribed in 25.1102(e), insert the following provision: Notice of Required Use of American Iron, Steel,...

  4. 48 CFR 52.225-22 - Notice of Required Use of American Iron, Steel, and Manufactured Goods-Buy American Act...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... American Iron, Steel, and Manufactured Goods-Buy American Act-Construction Materials. 52.225-22 Section 52... Required Use of American Iron, Steel, and Manufactured Goods—Buy American Act—Construction Materials. As prescribed in 25.1102(e), insert the following provision: Notice of Required Use of American Iron, Steel,...

  5. 41 CFR 301-10.137 - What exceptions to the Fly America Act requirements apply when I travel solely outside the United...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... or more; or (b) Extend your travel time by 6 hours or more; or (c) Require a connecting time of 4... Fly America Act requirements apply when I travel solely outside the United States, and a U.S. flag air... Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL...

  6. 41 CFR 301-10.136 - What exceptions to the Fly America Act requirements apply when I travel between the United States...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... destination, you must use the U.S. flag air carrier service unless such use would extend your travel time... the U.S. by 2 or more; or (2) Extend your travel time by at least 6 hours or more; or (3) Require a... Fly America Act requirements apply when I travel between the United States and another country?...

  7. 40 CFR 62.14830 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... operating permit unless you meet the relevant requirements specified in 40 CFR 62.14525(a) through (h) and (j) through (o) and all of the requirements specified in 40 CFR 62.14531. ... an operating permit under title V of the Clean Air Act? 62.14830 Section 62.14830 Protection...

  8. 40 CFR 62.14830 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... operating permit unless you meet the relevant requirements specified in 40 CFR 62.14525(a) through (h) and (j) through (o) and all of the requirements specified in 40 CFR 62.14531. ... an operating permit under title V of the Clean Air Act? 62.14830 Section 62.14830 Protection...

  9. 40 CFR 62.14830 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... operating permit unless you meet the relevant requirements specified in 40 CFR 62.14525(a) through (h) and (j) through (o) and all of the requirements specified in 40 CFR 62.14531. ... an operating permit under title V of the Clean Air Act? 62.14830 Section 62.14830 Protection...

  10. 40 CFR 62.14830 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... operating permit unless you meet the relevant requirements specified in 40 CFR 62.14525(a) through (h) and (j) through (o) and all of the requirements specified in 40 CFR 62.14531. ... an operating permit under title V of the Clean Air Act? 62.14830 Section 62.14830 Protection...

  11. 48 CFR 52.225-22 - Notice of Required Use of American Iron, Steel, and Manufactured Goods-Buy American Act...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... American Iron, Steel, and Manufactured Goods-Buy American Act-Construction Materials. 52.225-22 Section 52... Required Use of American Iron, Steel, and Manufactured Goods—Buy American Act—Construction Materials. As prescribed in 25.1102(e), insert the following provision: Notice of Required Use of American Iron, Steel,...

  12. 48 CFR 52.225-22 - Notice of Required Use of American Iron, Steel, and Manufactured Goods-Buy American Act...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... American Iron, Steel, and Manufactured Goods-Buy American Act-Construction Materials. 52.225-22 Section 52... Required Use of American Iron, Steel, and Manufactured Goods—Buy American Act—Construction Materials. As prescribed in 25.1102(e), insert the following provision: Notice of Required Use of American Iron, Steel,...

  13. 40 CFR 62.14830 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... operating permit unless you meet the relevant requirements specified in 40 CFR 62.14525(a) through (h) and (j) through (o) and all of the requirements specified in 40 CFR 62.14531. ... an operating permit under title V of the Clean Air Act? 62.14830 Section 62.14830 Protection...

  14. 41 CFR 301-10.136 - What exceptions to the Fly America Act requirements apply when I travel between the United States...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... destination, you must use the U.S. flag air carrier service unless such use would extend your travel time... the U.S. by 2 or more; or (2) Extend your travel time by at least 6 hours or more; or (3) Require a... Fly America Act requirements apply when I travel between the United States and another country?...

  15. 41 CFR 301-10.137 - What exceptions to the Fly America Act requirements apply when I travel solely outside the United...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... or more; or (b) Extend your travel time by 6 hours or more; or (c) Require a connecting time of 4... Fly America Act requirements apply when I travel solely outside the United States, and a U.S. flag air... Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL...

  16. BACT analysis under the Clean Air Act's PCD program

    SciTech Connect

    Simms, P.; Walke, J.

    2006-11-15

    Before a company may build a new major industrial source of air pollution, or make modifications to an existing major source in the USA it must apply for and receive a Clean Air Act (CAA) Prevention of Significant Deterioration (PSD) permit. State environmental agencies typically issue such permits, either under state law or by exercising delegated authority to implement the federal PSD program. To fully comply with the CAA, the emissions limits identified as BACT must incorporate consideration of more than just add-on emissions control technology, they must also reflect appropriate considerations of fuel quality (e.g. low-sulfur coal) and process changes (e.g. advanced combustion techniques) as a means of controlling emissions, and must consider the other environmental and public welfare benefits of the identified emissions control options. Several states including New Mexico and Illinois have already determined that innovated technologies, such as Integrated Gasification Combined Cycle (IGCC), must be considered in connection with the BACT analysis for new coal-fired power plants. Even the notion that BACT is categorically limited in scope to the general type of facility proposed is contrary to EPA precedent. For example, the Environmental Appeals Board (EAB) has explained that permitting authorities retain the discretion under the definition of BACT to require dramatically different facility designs (e.g. a natural gas plant instead of a coal-fired power plant). The best advice for any permit applicant is to include in the BACT analysis a careful and honest examination of better performing alternative processes and/or innovative combustion techniques and to aggressively pursue such options wherever feasible. 17 refs.

  17. A Standard Analysis Method (SAM) for the automated analysis of polychlorinated biphenyls (PCBs) in soils using the chemical analysis automation (CAA) paradigm: Validation and performance

    SciTech Connect

    Rzeszutko, C.; Johnson, C.R.; Monagle, M.; Klatt, L.N.

    1997-11-01

    The Chemical Analysis Automation (CAA) program is developing a standardized modular automation strategy for chemical analysis. In this automation concept, analytical chemistry is performed with modular building blocks that correspond to individual elements of the steps in the analytical process. With a standardized set of behaviors and interactions, these blocks can be assembled in a plug-and-play manner into a complete analysis system. These building blocks, which are referred to as Standard laboratory Modules (SLM), interface to a host control system that orchestrates the entire analytical process, from sample preparation through data interpretation. The integrated system is called a Standard Analysis Method (SAM). A SAM for the automated determination of polychlorinated biphenyls (PCBs) in soils, assembled in a mobile laboratory, is undergoing extensive testing and validation. The SAM consists of the following SLMs: a four-channel Soxhlet extractor, a high-volume concentration, a column clean-up, a gas chromatography, a PCB data-interpretation module, a robot, and a human-computer interface. The SAM is configured to meet the requirements specified in the US Environmental Protection Agency`s (EPA) SW-846 methods 3541/3620A/8082 for the analysis of PCBs in soils. The PCB SAM will be described along with the developmental test plan. Performance data obtained during developmental testing will also be discussed.

  18. A standard analysis method (SAM) for the automated analysis of polychlorinated biphenyls (PCBs) in soils using the chemical analysis automation (CAA) paradigm: validation and performance

    SciTech Connect

    Rzeszutko, C.; Johnson, C.R.; Monagle, M.; Klatt, L.N.

    1997-10-01

    The Chemical Analysis Automation (CAA) program is developing a standardized modular automation strategy for chemical analysis. In this automation concept, analytical chemistry is performed with modular building blocks that correspond to individual elements of the steps in the analytical process. With a standardized set of behaviors and interactions, these blocks can be assembled in a `plug and play` manner into a complete analysis system. These building blocks, which are referred to as Standard Laboratory Modules (SLM), interface to a host control system that orchestrates the entire analytical process, from sample preparation through data interpretation. The integrated system is called a Standard Analysis Method (SAME). A SAME for the automated determination of Polychlorinated Biphenyls (PCB) in soils, assembled in a mobile laboratory, is undergoing extensive testing and validation. The SAME consists of the following SLMs: a four channel Soxhlet extractor, a High Volume Concentrator, column clean up, a gas chromatograph, a PCB data interpretation module, a robot, and a human- computer interface. The SAME is configured to meet the requirements specified in U.S. Environmental Protection Agency`s (EPA) SW-846 Methods 3541/3620A/8082 for the analysis of pcbs in soils. The PCB SAME will be described along with the developmental test plan. Performance data obtained during developmental testing will also be discussed.

  19. A Safety and Health Guide for Vocational Educators. Incorporating Requirements of the Occupational Safety and Health Act of 1970, Relevant Pennsylvania Requirements with Particular Emphasis for Those Concerned with Cooperative Education and Work Study Programs. Volume 15. Number 1.

    ERIC Educational Resources Information Center

    Wahl, Ray

    Intended as a guide for vocational educators to incorporate the requirements of the Occupational Safety and Health Act (1970) and the requirements of various Pennsylvania safety and health regulations with their cooperative vocational programs, the first chapter of this document presents the legal implications of these safety and health…

  20. DEVELOPMENT OF WATER SUPPLY TECHNOLOGY TO MEET THE REQUIREMENTS OF THE SAFE DRINKING WATER ACT OF 1996: TRENDS AND PROSPECTS.

    EPA Science Inventory

    The passage of the U.S. Safe Drinking Water Act (SDWA) in 1974 has had a major impact on the way water is treated and delivered in the U.S. The Act established national drinking water regulations for more than 170,000 public drinking water systems serving over 250 million people ...

  1. Evaluation of a Structured Assessment Framework to Enable Adherence to the Requirements of Mental Capacity Act 2005

    ERIC Educational Resources Information Center

    Ramasubramanian, Lakshmiprabha; Ranasinghe, Newton; Ellison, Joseph

    2011-01-01

    The Mental Capacity Act 2005 for England and Wales received Royal assent in April 2005 and came into force in 2007 (Department of Constitutional Affairs, 2007). The Mental Capacity Act 2005 provides a statutory framework to empower and protect vulnerable people who are not able to make their own decisions. The adherence to it is a statutory…

  2. 76 FR 26787 - Short Sale Reporting Study Required by Dodd-Frank Act Section 417(a)(2)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-09

    ...(b)(8). \\4\\ See 17 CFR 242.200(a). \\5\\ See Exchange Act Release No. 50103 (July 28, 2004), 69 FR...., Exchange Act Release No. 58775 (Oct. 14, 2008), 73 FR 61690 (Oct. 17, 2008). \\13\\ In adopting Regulation.... 50103, 69 FR 48008, 48015 (Aug. 6, 2004) (citations omitted). Q3. The Commission requests comment on...

  3. 77 FR 59186 - Clean Air Act Operating Permit Program; Petition for Objection to State Operating Permit for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-26

    ..., 2011, and submitted by the Environmental Integrity Project and the Southern Alliance for Clean Energy... AGENCY Clean Air Act Operating Permit Program; Petition for Objection to State Operating Permit for...: Pursuant to Clean Air Act (CAA) Section 505(b)(2), the EPA Administrator signed an Order, dated August...

  4. 76 FR 53452 - Clean Air Act Operating Permit Program; Response to Petition To Reopen the 2001 Title V Permit...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-26

    ... AGENCY Clean Air Act Operating Permit Program; Response to Petition To Reopen the 2001 Title V Permit for.... ] SUMMARY: Pursuant to the Clean Air Act (CAA), the Director of the EPA Region III Air Protection Division... Reliant Energy Mid-Atlantic Power Holdings, LLC, for its Portland Generating Station in Northampton...

  5. 16 CFR 803.30 - Formal and informal interpretations of requirements under the Act and the rules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS... of the act are or may be applicable and (3) the question(s) that the applicant wishes resolved....

  6. 16 CFR 803.30 - Formal and informal interpretations of requirements under the Act and the rules.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS... of the act are or may be applicable and (3) the question(s) that the applicant wishes resolved....

  7. 42 CFR 136.404 - What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and Indian Tribes or Tribal organizations receiving funds under... Protection and Family Violence Prevention § 136.404 What does the Indian Child Protection and Family...

  8. 42 CFR 136.404 - What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and Indian Tribes or Tribal organizations receiving funds under... Protection and Family Violence Prevention § 136.404 What does the Indian Child Protection and Family...

  9. 42 CFR 136.404 - What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and Indian Tribes or Tribal organizations receiving funds under... Protection and Family Violence Prevention § 136.404 What does the Indian Child Protection and Family...

  10. 42 CFR 136.404 - What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and Indian Tribes or Tribal organizations receiving funds under... Protection and Family Violence Prevention § 136.404 What does the Indian Child Protection and Family...

  11. 42 CFR 136.404 - What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and Indian Tribes or Tribal organizations receiving funds under... Protection and Family Violence Prevention § 136.404 What does the Indian Child Protection and Family...

  12. 41 CFR 301-10.136 - What exceptions to the Fly America Act requirements apply when I travel between the United States...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 4 2011-07-01 2011-07-01 false What exceptions to the Fly America Act requirements apply when I travel between the United States and another country? 301-10... Transportation Use of United States Flag Air Carriers § 301-10.136 What exceptions to the Fly America...

  13. 41 CFR 301-10.136 - What exceptions to the Fly America Act requirements apply when I travel between the United States...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What exceptions to the Fly America Act requirements apply when I travel between the United States and another country? 301-10... Transportation Use of United States Flag Air Carriers § 301-10.136 What exceptions to the Fly America...

  14. Standard Compliance: Guidelines to Help State and Alternative Fuel Provider Fleets Meet Their Energy Policy Act Requirements, 10 CFR Part 490 (Book)

    SciTech Connect

    Not Available

    2014-03-01

    This guidebook addresses the primary requirements of the Alternative Fuel Transportation Program to help state and alternative fuel provider fleets comply with the Energy Policy Act via the Standard Compliance option. It also addresses the topics that covered fleets ask about most frequently.

  15. Standard Compliance: Guidelines to Help State and Alternative Fuel Provider Fleets Meet Their Energy Policy Act Requirements, 10 CFR Part 490 (Book)

    SciTech Connect

    Not Available

    2012-04-01

    This guidebook addresses the primary requirements of the Alternative Fuel Transportation Program to help state and alternative fuel provider fleets comply with the Energy Policy Act via the Standard Compliance option. It also addresses the topics that covered fleets ask about most frequently.

  16. 48 CFR 52.225-21 - Required Use of American Iron, Steel, and Manufactured Goods-Buy American Act-Construction...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Iron, Steel, and Manufactured Goods-Buy American Act-Construction Materials. 52.225-21 Section 52.225... of American Iron, Steel, and Manufactured Goods—Buy American Act—Construction Materials. As prescribed in 25.1102(e), insert the following clause: Required Use of American Iron, Steel, and...

  17. 48 CFR 52.225-21 - Required Use of American Iron, Steel, and Manufactured Goods-Buy American Act-Construction...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Iron, Steel, and Manufactured Goods-Buy American Act-Construction Materials. 52.225-21 Section 52.225... of American Iron, Steel, and Manufactured Goods—Buy American Act—Construction Materials. As prescribed in 25.1102(e), insert the following clause: Required Use of American Iron, Steel, and...

  18. The Impact of the Adequate Yearly Progress Requirement of the Federal "No Child Left Behind" Act on Schools in the Great Lakes Region. Executive Summary

    ERIC Educational Resources Information Center

    Wiley, Edward W.; Mathis, William J.; Garcia, David R.

    2005-01-01

    This executive summary describes a study that finds nearly every school in the Great Lakes states is threatened to fail the Adequate Yearly Progress (AYP) requirements mandated by the federal "No Child Left Behind" (NCLB) Act. NCLB holds schools and districts accountable for student achievement on state standardized tests and schools that do not…

  19. The Impact of the Adequate Yearly Progress Requirement of the Federal "No Child Left Behind" Act on Schools in the Great Lakes Region

    ERIC Educational Resources Information Center

    Wiley, Edward W.; Mathis, William J.; Garcia, David R.

    2005-01-01

    This study finds that nearly every school in the Great Lakes states is threatened to fail the Adequate Yearly Progress (AYP) requirements mandated by the federal "No Child Left Behind" (NCLB) Act. NCLB holds schools and districts accountable for student achievement on state standardized tests and schools that do not make AYP face sanctions. A…

  20. 15 CFR 781.4 - U.S. Government requests for information needed to satisfy the requirements of the APR or the Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false U.S. Government requests for information needed to satisfy the requirements of the APR or the Act. 781.4 Section 781.4 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND...

  1. 21 CFR 21.70 - Disclosure and intra-agency use of records in Privacy Act Record Systems; no accounting required.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... and local government employees for use only in their work with the Food and Drug Administration, and... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Disclosure and intra-agency use of records in Privacy Act Record Systems; no accounting required. 21.70 Section 21.70 Food and Drugs FOOD AND...

  2. 21 CFR 21.70 - Disclosure and intra-agency use of records in Privacy Act Record Systems; no accounting required.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... and local government employees for use only in their work with the Food and Drug Administration, and... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Disclosure and intra-agency use of records in Privacy Act Record Systems; no accounting required. 21.70 Section 21.70 Food and Drugs FOOD AND...

  3. 17 CFR 270.18f-1 - Exemption from certain requirements of section 18(f)(1) (of the Act) for registered open-end...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... requirements of section 18(f)(1) (of the Act) for registered open-end investment companies which have the right... which have the right to redeem in kind. (a) A registered open-end investment company which has the right... to pay in cash all requests for redemption by any shareholder of record, limited in amount...

  4. Primer for Maintaining Accurate Special Education Records and Meeting Confidentiality Requirements When Serving Children with Disabilities--Family Educational Rights and Privacy Act (FERPA).

    ERIC Educational Resources Information Center

    Copenhaver, John

    This manual is intended to provide schools with guidance in complying with federal laws and regulations regarding record keeping and confidentiality in their services to students with disabilities. Part 1 focuses on requirements of the Family Education Rights and Privacy Act (FERPA), which ensures student/parent access to education records and…

  5. 41 CFR 301-10.136 - What exceptions to the Fly America Act requirements apply when I travel between the United States...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 4 2014-07-01 2014-07-01 false What exceptions to the Fly America Act requirements apply when I travel between the United States and another country? 301-10... Transportation Use of United States Flag Air Carriers § 301-10.136 What exceptions to the Fly America...

  6. 48 CFR 52.225-21 - Required Use of American Iron, Steel, and Manufactured Goods-Buy American Act-Construction...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Iron, Steel, and Manufactured Goods-Buy American Act-Construction Materials. 52.225-21 Section 52.225... of American Iron, Steel, and Manufactured Goods—Buy American Act—Construction Materials. As prescribed in 25.1102(e), insert the following clause: Required Use of American Iron, Steel, and...

  7. 48 CFR 52.225-21 - Required Use of American Iron, Steel, and Manufactured Goods-Buy American Act-Construction...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Iron, Steel, and Manufactured Goods-Buy American Act-Construction Materials. 52.225-21 Section 52.225... of American Iron, Steel, and Manufactured Goods—Buy American Act—Construction Materials. As prescribed in 25.1102(e), insert the following clause: Required Use of American Iron, Steel, and...

  8. Early detection of circulating anodic antigen (CAA) in a case of acute schistosomiasis mansoni with Katayama fever.

    PubMed

    Gundersen, S G; Ravn, J; Haagensen, I

    1992-01-01

    A 34-year-old male developed acute Katayama fever with fever, diarrhoea, joint pains, headache, urticarial rash and eosinophilia 18 days after falling into and spending 15 min in the water during water-skiing in the outlet of the Volta river. Low anti-schistosomal antibody titres were found by the immunofluorescence assay after 4 weeks, and the first Schistosoma mansoni eggs were found in faeces after 6 weeks. Both symptoms and eosinophilia increased the first days after treatment with oxamniquine, after which he improved gradually. Examination of frozen sera by the newly developed Magnetic Beads Antigen Capture-EIA (MBAC-EIA) later demonstrated a peak in schistosomal circulating anodic antigen (CAA) levels of diagnostic significance already 4 weeks after he was infected. PMID:1411323

  9. Early detection of circulating anodic antigen (CAA) in a case of acute schistosomiasis mansoni with Katayama fever.

    PubMed

    Gundersen, S G; Ravn, J; Haagensen, I

    1992-01-01

    A 34-year-old male developed acute Katayama fever with fever, diarrhoea, joint pains, headache, urticarial rash and eosinophilia 18 days after falling into and spending 15 min in the water during water-skiing in the outlet of the Volta river. Low anti-schistosomal antibody titres were found by the immunofluorescence assay after 4 weeks, and the first Schistosoma mansoni eggs were found in faeces after 6 weeks. Both symptoms and eosinophilia increased the first days after treatment with oxamniquine, after which he improved gradually. Examination of frozen sera by the newly developed Magnetic Beads Antigen Capture-EIA (MBAC-EIA) later demonstrated a peak in schistosomal circulating anodic antigen (CAA) levels of diagnostic significance already 4 weeks after he was infected.

  10. 75 FR 27580 - Notice of Lodging of Consent Decree Under the Clean Air Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-17

    ... proposed Consent Decree (``Decree'') in United States v. The Pep Boys--Manny, Moe & Jack, and Baja, Inc.... EPA''), sought penalties and injunctive relief under the Clean Air Act (``CAA'') against The Pep Boys... of Justice, Washington, DC 20044-7611, and should refer to United States v. The Pep Boys--Manny,...

  11. 76 FR 76762 - Notice of Lodging of Consent Decree Under the Clean Air Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-08

    ... Clean Air Act (``CAA''), 42 U.S.C. 7413(b) and 7477. Defendant produces nitric acid, which is used in the production of ammonium nitrate and other fertilizers and explosives. The nitric acid process results in the emissions of regulated air pollutants, including nitrogen oxides (``NO X ''). The...

  12. 76 FR 22918 - Notice of Lodging of Consent Decree Pursuant to the Clean Air Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-25

    ..., 2011, a proposed Consent Decree in United States et al. v. Terra Industries Inc. et al., Civ. A. No. 5... and injunctive relief for violations of the Clean Air Act (``CAA'') by Terra Industries Inc. (``Terra Industries''), Terra International (Oklahoma) Inc. (``Terra Oklahoma''), Terra Nitrogen, Limited...

  13. 75 FR 32210 - Notice of Lodging of Consent Decree Under the Clean Air Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-07

    ... proposed Consent Decree (``Decree'') in United States v. The Scrap Yard, LLC, d/b/a/ Cleveland Scrap, Civil.... EPA''), sought penalties and injunctive relief under the Clean Air Act (``CAA'') against The Scrap Yard, LLC, d/b/a/Cleveland Scrap (``Defendant'') relating to Defendant's Cleveland, Ohio...

  14. 15 CFR 744.11 - License requirements that apply to entities acting contrary to the national security or foreign...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... entities acting contrary to the national security or foreign policy interests of the United States. 744.11...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY... national security or foreign policy interests of the United States. BIS may impose foreign policy...

  15. Child Labor Requirements in Nonagricultural Occupations under the Fair Labor Standards Act. Child Labor Bulletin No. 101.

    ERIC Educational Resources Information Center

    Employment Standards Administration (DOL), Washington, DC. Wage and Hour Div.

    This booklet is a guide to the provisions of the Fair Labor Standards Act (also known as the Wage-Hour Law) which apply to minors employed in nonagricultural occupations. The content is as follows: coverage of the child labor provisions (covers employees in commerce, the production of goods for commerce, an enterprise engaged in commerce, and an…

  16. 15 CFR 744.11 - License requirements that apply to entities acting contrary to the national security or foreign...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... entities acting contrary to the national security or foreign policy interests of the United States. 744.11...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY... national security or foreign policy interests of the United States. BIS may impose foreign policy...

  17. 15 CFR 744.11 - License requirements that apply to entities acting contrary to the national security or foreign...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... entities acting contrary to the national security or foreign policy interests of the United States. 744.11...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY... national security or foreign policy interests of the United States. BIS may impose foreign policy...

  18. 75 FR 44163 - Implementation of Regulations Required Under Title XI of the Food, Conservation and Energy Act of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-28

    ... Administration (GIPSA) published a proposed rule in the Federal Register on June 22, 2010 (75 FR 35338) proposing...; ] DEPARTMENT OF AGRICULTURE Grain Inspection, Packers and Stockyards Administration 9 CFR Part 201 RIN 0580... 2008; Conduct in Violation of the Act AGENCY: Grain Inspection, Packers and Stockyards...

  19. 49 CFR Appendix A to Part 228 - Requirements of the Hours of Service Act: Statement of Agency Policy and Interpretation

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... for one employee including one hour lunch period) Do. 7 a.m. to 3 p.m. 7 a.m. to 3 p.m. (Two employees... time if it provides a meaningful period of relaxation and if the employee is free of all... Act which do not afford such persons an opportunity for rest, free from interruptions caused by...

  20. 49 CFR Appendix A to Part 228 - Requirements of the Hours of Service Act: Statement of Agency Policy and Interpretation

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... for one employee including one hour lunch period) Do. 7 a.m. to 3 p.m. 7 a.m. to 3 p.m. (Two employees... time if it provides a meaningful period of relaxation and if the employee is free of all... Act which do not afford such persons an opportunity for rest, free from interruptions caused by...

  1. Do Stricter High School Graduation Requirements Improve College Readiness? ACT Working Paper Series. WP-2014-1

    ERIC Educational Resources Information Center

    Buddin, Richard; Croft, Michelle

    2014-01-01

    In recent years, state policymakers have increased high school course requirements--particularly in mathematics and science. This research examines whether stricter requirements have been effective at improving student outcomes. Student-level evidence from a state's recent reform suggests that higher requirements had little effect on trends in…

  2. Cross-talk between Aβ and endothelial SSAO/VAP-1 accelerates vascular damage and Aβ aggregation related to CAA-AD.

    PubMed

    Solé, Montse; Miñano-Molina, Alfredo J; Unzeta, Mercedes

    2015-02-01

    An association between semicarbazide-sensitive amine oxidase (SSAO) and cerebral amyloid angiopathy (CAA) related to Alzheimer's disease (AD) has been largely postulated. Increased SSAO activity and expression have been detected in cerebrovascular tissue and plasma of AD patients, colocalizing with cerebrovascular amyloid-beta (Aβ) deposits. As an enzyme, SSAO metabolizes primary amines generating hydrogen peroxide, ammonia, and aldehydes. The ability of these products to generate oxidative stress, to enhance the advanced glycation end-product generation, to promote the Aβ aggregation in vitro, and to induce apoptosis supports its role in CAA-related vascular pathology. However, whether the SSAO increase constitutes a cause or it is a consequence of the pathologic process has not been elucidated so far. To set up the nature of this relationship, vascular cell models expressing SSAO were treated with different Aβ forms, simulating the CAA conditions in vitro. It was found that the presence of the vasculotropic Dutch-mutated Aβ1-40 increases (Aβ1-40 D) the SSAO-dependent toxicity, which is accompanied by an increase of SSAO protein availability in endothelial cell membranes. In addition, SSAO enhances Aβ1-40 D and Aβ1-42 deposition on vascular cells by both activity-dependent and -independent mechanisms. Thus, we provide evidences indicating that Aβ itself could be one of the factors inducing SSAO increase in AD, enhancing its toxic effect, and inducing the vascular dysfunction and, in turn, that SSAO stimulates Aβ deposition on the vascular walls, thereby contributing to the CAA-AD progression. Therefore, molecules inhibiting SSAO could provide an alternative treatment for preventing/delaying the progress of CAA-AD-associated vasculopathy.

  3. 49 CFR Appendix A to Part 228 - Requirements of the Hours of Service Act: Statement of Agency Policy and Interpretation

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... including one hour lunch period) Do. 7 a.m. to 3 p.m. 7 a.m. to 3 p.m. (Two employees scheduled) Do. 7 a.m... time if it provides a meaningful period of relaxation and if the employee is free of all... Act which do not afford such persons an opportunity for rest, free from interruptions caused by...

  4. 49 CFR Appendix A to Part 228 - Requirements of the Hours of Service Act: Statement of Agency Policy and Interpretation

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... including one hour lunch period) Do. 7 a.m. to 3 p.m. 7 a.m. to 3 p.m. (Two employees scheduled) Do. 7 a.m... time if it provides a meaningful period of relaxation and if the employee is free of all... Act which do not afford such persons an opportunity for rest, free from interruptions caused by...

  5. The clinical profile of children with ADHD that require OROS-methylphenidate combined with shorter-acting formulations.

    PubMed

    Zelnik, Nathanel; Terkel-Dawer, Ruth

    2015-12-01

    Long-acting methylphenidate (MPH) formulations, including OROS-MPH, were found to be effective in alleviating ADHD symptoms throughout the day. However, sustained stimulant activity may lead to prolonged suppression of appetite and insomnia. In this study, we characterized the clinical profile of children and adolescents for whom a once-daily lower dose of OROS-MPH combined with a shorter-acting agent was more tolerable than single higher OROS-MPH dose. In our cohort of 128 children treated with OROS-MPH, 47 (36.7 %) better tolerated a lower dose of OROS-MPH combined with short-acting MPH formulations (Group I). Nevertheless, for the majority (81 patients-63.3 %), a standard single moderate dose of OROS-MPH was sufficient (Group II). The mean daily doses of MPH were: 0.83 ± 0.21 mg/kg for Group I and 1.06 ± 0.29 mg/kg for Group II. There were no significant differences in the prevalence of learning disorders, tic disorders, epilepsy and conduct disorders between these two groups. However, anxiety and marginally depression were more prevalent in Group I (46.8 and 9.7 %) than in Group II (27.2 and 1.2 %). Patients in Group I were also more tending to receive psychotherapy than patients in Group II.

  6. 17 CFR 240.19b-5 - Temporary exemption from the filing requirements of Section 19(b) of the Act.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... requirements: (1) Form PILOT. The self-regulatory organization: (i) Files Part I of Form PILOT, 17 CFR 249.821... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Temporary exemption from the... of Exchange Members § 240.19b-5 Temporary exemption from the filing requirements of Section 19(b)...

  7. 15 CFR Supplement No. 1 to Part 730 - Information Collection Requirements Under the Paperwork Reduction Act: OMB Control Numbers

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Information Collection Requirements... requirements for the Bureau of Industry and Security by the Office of Management and Budget (OMB), pursuant...

  8. 15 CFR Supplement No. 1 to Part 730 - Information Collection Requirements Under the Paperwork Reduction Act: OMB Control Numbers

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Information Collection Requirements... requirements for the Bureau of Industry and Security by the Office of Management and Budget (OMB), pursuant...

  9. 15 CFR Supplement No. 1 to Part 730 - Information Collection Requirements Under the Paperwork Reduction Act: OMB Control Numbers

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Information Collection Requirements... requirements for the Bureau of Industry and Security by the Office of Management and Budget (OMB), pursuant...

  10. ICASE/LaRC Workshop on Benchmark Problems in Computational Aeroacoustics (CAA)

    NASA Technical Reports Server (NTRS)

    Hardin, Jay C. (Editor); Ristorcelli, J. Ray (Editor); Tam, Christopher K. W. (Editor)

    1995-01-01

    The proceedings of the Benchmark Problems in Computational Aeroacoustics Workshop held at NASA Langley Research Center are the subject of this report. The purpose of the Workshop was to assess the utility of a number of numerical schemes in the context of the unusual requirements of aeroacoustical calculations. The schemes were assessed from the viewpoint of dispersion and dissipation -- issues important to long time integration and long distance propagation in aeroacoustics. Also investigated were the effect of implementation of different boundary conditions. The Workshop included a forum in which practical engineering problems related to computational aeroacoustics were discussed. This discussion took the form of a dialogue between an industrial panel and the workshop participants and was an effort to suggest the direction of evolution of this field in the context of current engineering needs.

  11. Enlarged meristems and delayed growth in plp mutants result from lack of CaaX prenyltransferases.

    PubMed

    Running, Mark P; Lavy, Meirav; Sternberg, Hasana; Galichet, Arnaud; Gruissem, Wilhelm; Hake, Sarah; Ori, Naomi; Yalovsky, Shaul

    2004-05-18

    Meristems require a myriad of intercellular signaling pathways for coordination of cell division within and between functional zones and clonal cell layers. This control of cell division ensures a constant availability of stem cells throughout the life span of the meristem while limiting overproliferation of meristematic cells and maintaining the meristem structure. We have undertaken a genetic screen to identify additional components of meristem signaling pathways. We identified pluripetala (plp) mutants based on their dramatically larger meristems and increased floral organ number. PLURIPETALA encodes the alpha-subunit shared between protein farnesyltransferase and protein geranylgeranyltransferase-I. plp mutants also have altered abscisic acid responses and overall much slower growth rate. plp is epistatic to mutations in the beta-subunit of farnesyltransferase and shows a synergistic interaction with clavata3 mutants. plp mutants lead to insights into the mechanism of meristem homeostasis and provide a unique in vivo system for studying the functional role of prenylation in eukaryotes.

  12. Enlarged meristems and delayed growth in plp mutants result from lack of CaaX prenyltransferases

    PubMed Central

    Running, Mark P.; Lavy, Meirav; Sternberg, Hasana; Galichet, Arnaud; Gruissem, Wilhelm; Hake, Sarah; Ori, Naomi; Yalovsky, Shaul

    2004-01-01

    Meristems require a myriad of intercellular signaling pathways for coordination of cell division within and between functional zones and clonal cell layers. This control of cell division ensures a constant availability of stem cells throughout the life span of the meristem while limiting overproliferation of meristematic cells and maintaining the meristem structure. We have undertaken a genetic screen to identify additional components of meristem signaling pathways. We identified pluripetala (plp) mutants based on their dramatically larger meristems and increased floral organ number. PLURIPETALA encodes the α-subunit shared between protein farnesyltransferase and protein geranylgeranyltransferase-I. plp mutants also have altered abscisic acid responses and overall much slower growth rate. plp is epistatic to mutations in the β-subunit of farnesyltransferase and shows a synergistic interaction with clavata3 mutants. plp mutants lead to insights into the mechanism of meristem homeostasis and provide a unique in vivo system for studying the functional role of prenylation in eukaryotes. PMID:15128936

  13. 45 CFR 1356.40 - Adoption assistance program: Administrative requirements to implement section 473 of the Act.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... participation in adoption assistance payments under this part, the State must meet the requirements of this... moves from one State to another State, the family may apply for social services on behalf of...

  14. 15 CFR 744.11 - License requirements that apply to entities acting contrary to the national security or foreign...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., repair, development, or production by supplying parts, components, technology, or financing for such... party to be listed and the failure to produce a complete, accurate and useful check is required,...

  15. 12 CFR 208.36 - Reporting requirements for State member banks subject to the Securities Exchange Act of 1934.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... recent fiscal year, and no foreign offices, may elect to substitute for the financial statements required... 10 of the Commission's Regulation S-X (17 CFR 210.10-01), in the Management's Discussion and Analysis... document filed with the Board. Each copy of the confidential portion shall contain the complete text of...

  16. 12 CFR 208.36 - Reporting requirements for State member banks subject to the Securities Exchange Act of 1934.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... recent fiscal year, and no foreign offices, may elect to substitute for the financial statements required... 10 of the Commission's Regulation S-X (17 CFR 210.10-01), in the Management's Discussion and Analysis... document filed with the Board. Each copy of the confidential portion shall contain the complete text of...

  17. 12 CFR 208.36 - Reporting requirements for State member banks subject to the Securities Exchange Act of 1934.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... recent fiscal year, and no foreign offices, may elect to substitute for the financial statements required... 10 of the Commission's Regulation S-X (17 CFR 210.10-01), in the Management's Discussion and Analysis... document filed with the Board. Each copy of the confidential portion shall contain the complete text of...

  18. 15 CFR Supplement No. 1 to Part 730 - Information Collection Requirements Under the Paperwork Reduction Act: OMB Control Numbers

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS GENERAL INFORMATION Pt. 730, Supp. 1... requirements for the Bureau of Industry and Security by the Office of Management and Budget (OMB), pursuant to...-Disclosure of Antiboycott Violations § 764.8. 0694-0133 Thermal Imaging Camera Reporting § 743.3...

  19. 15 CFR Supplement No. 1 to Part 730 - Information Collection Requirements Under the Paperwork Reduction Act: OMB Control Numbers

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS GENERAL INFORMATION Pt. 730, Supp. 1... requirements for the Bureau of Industry and Security by the Office of Management and Budget (OMB), pursuant to... Antiboycott Violations § 764.8. 0694-0133 Thermal Imaging Camera Reporting § 743.3 0694-0134 Procedure...

  20. 45 CFR 1356.40 - Adoption assistance program: Administrative requirements to implement section 473 of the Act.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN... ASSISTANCE, AND CHILD AND FAMILY SERVICES REQUIREMENTS APPLICABLE TO TITLE IV-E § 1356.40 Adoption assistance... assistance program provisions of the title IV-E State plan and to be eligible for Federal...

  1. 75 FR 35338 - Implementation of Regulations Required Under Title XI of the Food, Conservation and Energy Act of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-22

    ...; ] DEPARTMENT OF AGRICULTURE Grain Inspection, Packers and Stockyards Administration 9 CFR Part 201 RIN 0580..., USDA. ACTION: Proposed rule. SUMMARY: The Department of Agriculture (USDA), Grain Inspection, Packers... in the livestock and poultry industries and required the Secretary of Agriculture (Secretary)...

  2. 75 FR 31334 - Real Estate Settlement Procedures Act (RESPA): Strengthening and Clarifying RESPA's “Required Use...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-03

    ..., 2009 (74 FR 22822). When HUD withdrew the revised definition, it left in place the existing definition..., without sufficient time to research their contracts or to comparison shop. The purpose of this ANPR is to... definition of the ``required use'' of affiliated settlement service providers in residential...

  3. 76 FR 76874 - Implementation of Regulations Required Under Title XI of the Food, Conservation and Energy Act of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-09

    ... on these comments. Section V provides the revised impact analyses including those required by..., (75 FR 35338) provided a 60-day comment period to end on August 23, 2010. In response to requests for... November 22, 2010 (75 FR 44163). GIPSA considered all comments postmarked or electronically submitted...

  4. 15 CFR 744.11 - License requirements that apply to entities acting contrary to the national security or foreign...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... section by adding an entity to the Entity List (Supp. No. 4 to this part) with a reference to this section and by stating on the Entity List the license requirements and license application review policy that apply to that entity. BIS may remove an entity from the Entity List if it is no longer engaged in...

  5. National School Lunch Program and School Breakfast Program: Eliminating Applications Through Community Eligibility as Required by the Healthy, Hunger-Free Kids Act of 2010. Final rule.

    PubMed

    2016-07-29

    This final rule establishes requirements for State agencies, local educational agencies, and schools operating the Community Eligibility Provision, a reimbursement option that allows the service of school meals to all children at no-cost in high poverty schools without collecting household applications. By eliminating the household application process and streamlining meal counting and claiming procedures through the Community Eligibility Provision, local educational agencies may substantially reduce administrative burden related to operating the National School Lunch and School Breakfast Programs. This rule codifies many requirements that were implemented through policy guidance following enactment of the Healthy, Hunger-Free Kids Act of 2010, as well as provisions of the proposed rule. These requirements will result in consistent, national implementation of the Community Eligibility Provision.

  6. National School Lunch Program and School Breakfast Program: Eliminating Applications Through Community Eligibility as Required by the Healthy, Hunger-Free Kids Act of 2010. Final rule.

    PubMed

    2016-07-29

    This final rule establishes requirements for State agencies, local educational agencies, and schools operating the Community Eligibility Provision, a reimbursement option that allows the service of school meals to all children at no-cost in high poverty schools without collecting household applications. By eliminating the household application process and streamlining meal counting and claiming procedures through the Community Eligibility Provision, local educational agencies may substantially reduce administrative burden related to operating the National School Lunch and School Breakfast Programs. This rule codifies many requirements that were implemented through policy guidance following enactment of the Healthy, Hunger-Free Kids Act of 2010, as well as provisions of the proposed rule. These requirements will result in consistent, national implementation of the Community Eligibility Provision. PMID:27476197

  7. 76 FR 30545 - Approval of the Clean Air Act, Section 112(l), Authority for Hazardous Air Pollutants...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-26

    ...Pursuant to section 112(l) of the Clean Air Act (``CAA'') and Federal regulations promulgated thereunder, the Maine Department of Environmental Protection (``ME DEP'') submitted a request for approval to implement and enforce the amended ``Chapter 125: Perchloroethylene Dry Cleaner Regulation'' (Maine Dry Cleaner Rule) as a partial substitution for the amended National Emissions Standards for......

  8. 76 FR 54465 - Proposed Settlement Agreement, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-01

    ...In accordance with section 113(g) of the Clean Air Act, as amended (``CAA'' or the ``Act''), notice is hereby given of a proposed settlement agreement to address a lawsuit filed by Sierra Club and WildEarth Guardians in the United States District Court for the Northern District of California: Sierra Club et al. v. Jackson, No. 3:10-cv-04060-CRB (N.D. Cal.). On August 10, 2011, Plaintiffs filed......

  9. ERA, a novel cis-acting element required for autoregulation and ethanol repression of PDC1 transcription in Saccharomyces cerevisiae.

    PubMed

    Liesen, T; Hollenberg, C P; Heinisch, J J

    1996-08-01

    Yeast pyruvate decarboxylase (Pdc) catalyses the reaction at the branch-point of fermentation and respiration. In this work we have investigated the mechanisms of its transcriptional regulation in response to glucose and the non-fermentable carbon source ethanol. For this purpose we studied the function of different promoter fragments of PDC1, encoding the major pyruvate decarboxylase enzyme in wild-type cells, in the basal CYC1 promoter context. Thus, we identified a sequence mediating the response to ethanol and provide evidence showing that transcription of PDC1 is controlled by ethanol repression rather than by glucose induction. Furthermore, we showed that the same sequence is responsible for an autoregulatory process, leading to increased transcription from both the PDC1 and the PDC5 promoters, in strains in which the genomic copy of PDC1 is deleted. In addition, we have confirmed the role of Rap1 binding and have demonstrated that the Gcr1 protein also acts in transcriptional activation. DNA-protein interactions at the consensus Rap1-binding site and the newly identified ethanol-repression sequence (5'-AAATGCATA-3', termed 'ERA') were investigated by gel-shift and footprint analyses. Both DNA-binding activities were found in extracts from cells grown in media containing glucose or ethanol as the carbon source, indicating that the capacity to bind is not altered by the carbon source used.

  10. Phenothiazine-based CaaX competitive inhibitors of human farnesyltransferase bearing a cysteine, methionine, serine or valine moiety as a new family of antitumoral compounds.

    PubMed

    Dumitriu, Gina-Mirabela; Bîcu, Elena; Belei, Dalila; Rigo, Benoît; Dubois, Joëlle; Farce, Amaury; Ghinet, Alina

    2015-10-15

    A new family of CaaX competitive inhibitors of human farnesyltransferase based on phenothiazine and carbazole skeleton bearing a l-cysteine, l-methionine, l-serine or l-valine moiety was designed, synthesized and biologically evaluated. Phenothiazine derivatives proved to be more active than carbazole-based compounds. Phenothiazine 1b with cysteine residue was the most promising inhibitor of human farnesyltransferase in the current study.

  11. Combined effect of loss of the caa3 oxidase and Crp regulation drives Shewanella to thrive in redox-stratified environments.

    PubMed

    Zhou, Guangqi; Yin, Jianhua; Chen, Haijiang; Hua, Yijie; Sun, Linlin; Gao, Haichun

    2013-09-01

    Shewanella species are a group of facultative Gram-negative microorganisms with remarkable respiration abilities that allow the use of a diverse array of terminal electron acceptors (EA). Like most bacteria, S. oneidensis possesses multiple terminal oxidases, including two heme-copper oxidases (caa3- and cbb3-type) and a bd-type quinol oxidase. As aerobic respiration is energetically favored, mechanisms underlying the fact that these microorganisms thrive in redox-stratified environments remain vastly unexplored. In this work, we discovered that the cbb3-type oxidase is the predominant system for respiration of oxygen (O2), especially when O2 is abundant. Under microaerobic conditions, the bd-type quinol oxidase has a significant role in addition to the cbb3-type oxidase. In contrast, multiple lines of evidence suggest that under test conditions the caa3-type oxidase, an analog to the mitochondrial enzyme, has no physiological significance, likely because of its extremely low expression. In addition, expression of both cbb3- and bd-type oxidases is under direct control of Crp (cAMP receptor protein) but not the well-established redox regulator Fnr (fumarate nitrate regulator) of canonical systems typified in Escherichia coli. These data, collectively, suggest that adaptation of S. oneidensis to redox-stratified environments is likely due to functional loss of the caa3-type oxidase and switch of the regulatory system for respiration.

  12. Raffinose Family Oligosaccharides Act As Galactose Stores in Seeds and Are Required for Rapid Germination of Arabidopsis in the Dark.

    PubMed

    Gangl, Roman; Tenhaken, Raimund

    2016-01-01

    Raffinose synthase 5 (AtRS5, At5g40390) was characterized from Arabidopsis as a recombinant enzyme. It has a far higher affinity for the substrates galactinol and sucrose than any other raffinose synthase previously reported. In addition raffinose synthase 5 is also working as a galactosylhydrolase, degrading galactinol, and raffinose under certain conditions. Together with raffinose synthase 4, which is predominantly a stachyose synthase, both enzymes contribute to the raffinose family oligosaccharide (RFO) accumulation in seeds. A double knockout in raffinose synthase 4 and raffinose synthase 5 (ΔAtRS4,5) was generated, which is devoid of RFOs in seeds. Unstressed leaves of 4 week old ΔAtRS4,5 plants showed drastically 23.8-fold increased concentrations of galactinol. Unexpectedly, raffinose appeared again in drought stressed ΔAtRS4,5 plants, but not under other abiotic stress conditions. Drought stress leads to novel transcripts of raffinose synthase 6 suggesting that this isoform is a further stress inducible raffinose synthase in Arabidopsis. ΔAtRS4,5 seeds showed a 5 days delayed germination phenotype in darkness and an elevated expression of the transcription factor phytochrome interacting factor 1 (AtPIF1) target gene AtPIF6, being a repressor of germination. This prolonged dormancy is not seen during germination in the light. Exogenous galactose partially promotes germination of ΔAtRS4,5 seeds in the dark suggesting that RFOs act as a galactose store and repress AtPIF6 transcripts. PMID:27507985

  13. Raffinose Family Oligosaccharides Act As Galactose Stores in Seeds and Are Required for Rapid Germination of Arabidopsis in the Dark

    PubMed Central

    Gangl, Roman; Tenhaken, Raimund

    2016-01-01

    Raffinose synthase 5 (AtRS5, At5g40390) was characterized from Arabidopsis as a recombinant enzyme. It has a far higher affinity for the substrates galactinol and sucrose than any other raffinose synthase previously reported. In addition raffinose synthase 5 is also working as a galactosylhydrolase, degrading galactinol, and raffinose under certain conditions. Together with raffinose synthase 4, which is predominantly a stachyose synthase, both enzymes contribute to the raffinose family oligosaccharide (RFO) accumulation in seeds. A double knockout in raffinose synthase 4 and raffinose synthase 5 (ΔAtRS4,5) was generated, which is devoid of RFOs in seeds. Unstressed leaves of 4 week old ΔAtRS4,5 plants showed drastically 23.8-fold increased concentrations of galactinol. Unexpectedly, raffinose appeared again in drought stressed ΔAtRS4,5 plants, but not under other abiotic stress conditions. Drought stress leads to novel transcripts of raffinose synthase 6 suggesting that this isoform is a further stress inducible raffinose synthase in Arabidopsis. ΔAtRS4,5 seeds showed a 5 days delayed germination phenotype in darkness and an elevated expression of the transcription factor phytochrome interacting factor 1 (AtPIF1) target gene AtPIF6, being a repressor of germination. This prolonged dormancy is not seen during germination in the light. Exogenous galactose partially promotes germination of ΔAtRS4,5 seeds in the dark suggesting that RFOs act as a galactose store and repress AtPIF6 transcripts. PMID:27507985

  14. Prescription Drug Marketing Act of 1987; Prescription Drug Amendments of 1992; policies, requirements, and administrative procedures; delay of effective date. Final rule; delay of effective date.

    PubMed

    2004-02-23

    The Food and Drug Administration (FDA) is further delaying, until December 1, 2006, the effective date of certain requirements of a final rule published in the Federal Register of December 3, 1999 (64 FR 67720). In the Federal Register of May 3, 2000 (65 FR 25639), the agency delayed until October 1, 2001, the effective date of certain requirements in the final rule relating to wholesale distribution of prescription drugs by distributors that are not authorized distributors of record, and distribution of blood derivatives by entities that meet the definition of a "health care entity" in the final rule. The agency further delayed the effective date of these requirements in three subsequent Federal Register notices. Most recently, in the Federal Register of January 31, 2003 (68 FR 4912), FDA delayed the effective date until April 1, 2004. This action further delays the effective date of these requirements until December 1, 2006. The final rule implements the Prescription Drug Marketing Act of 1987 (PDMA), as modified by the Prescription Drug Amendments of 1992 (PDA), and the Food and Drug Administration Modernization Act of 1997 (the Modernization Act). The agency is taking this action to address concerns about the requirements in the final rule raised by affected parties. As explained in the SUPPLEMENTARY INFORMATION section, FDA is working with stakeholders through its counterfeit drug initiative to facilitate widespread, voluntary adoption of track and trace technologies that will generate a de facto electronic pedigree, including prior transaction history back to the original manufacturer, as a routine course of business. If this technology is widely adopted, it is expected to help fulfill the pedigree requirements of the PDMA and obviate or resolve many of the concerns that have been raised with respect to the final rule by ensuring that an electronic pedigree travels with a drug product at all times. Therefore, it is necessary to delay the effective date of Sec

  15. Prescription Drug Marketing Act of 1987; Prescription Drug Amendments of 1992; policies, requirements, and administrative procedures; delay of effective date. Final rule; delay of effective date.

    PubMed

    2004-02-23

    The Food and Drug Administration (FDA) is further delaying, until December 1, 2006, the effective date of certain requirements of a final rule published in the Federal Register of December 3, 1999 (64 FR 67720). In the Federal Register of May 3, 2000 (65 FR 25639), the agency delayed until October 1, 2001, the effective date of certain requirements in the final rule relating to wholesale distribution of prescription drugs by distributors that are not authorized distributors of record, and distribution of blood derivatives by entities that meet the definition of a "health care entity" in the final rule. The agency further delayed the effective date of these requirements in three subsequent Federal Register notices. Most recently, in the Federal Register of January 31, 2003 (68 FR 4912), FDA delayed the effective date until April 1, 2004. This action further delays the effective date of these requirements until December 1, 2006. The final rule implements the Prescription Drug Marketing Act of 1987 (PDMA), as modified by the Prescription Drug Amendments of 1992 (PDA), and the Food and Drug Administration Modernization Act of 1997 (the Modernization Act). The agency is taking this action to address concerns about the requirements in the final rule raised by affected parties. As explained in the SUPPLEMENTARY INFORMATION section, FDA is working with stakeholders through its counterfeit drug initiative to facilitate widespread, voluntary adoption of track and trace technologies that will generate a de facto electronic pedigree, including prior transaction history back to the original manufacturer, as a routine course of business. If this technology is widely adopted, it is expected to help fulfill the pedigree requirements of the PDMA and obviate or resolve many of the concerns that have been raised with respect to the final rule by ensuring that an electronic pedigree travels with a drug product at all times. Therefore, it is necessary to delay the effective date of Sec

  16. 2 CFR 1532.1115 - Can the EPA extend a CAA or CWA disqualification to other facilities?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Statutory Disqualification and Reinstatement Under the Clean Air Act and Clean Water Act § 1532.1115 Can the... person. The EPA also has authority under subparts A through I of 2 CFR part 180, or under 48 CFR part...

  17. 2 CFR 1532.1115 - Can the EPA extend a CAA or CWA disqualification to other facilities?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Statutory Disqualification and Reinstatement Under the Clean Air Act and Clean Water Act § 1532.1115 Can the... person. The EPA also has authority under subparts A through I of 2 CFR part 180, or under 48 CFR part...

  18. 2 CFR 1532.1115 - Can the EPA extend a CAA or CWA disqualification to other facilities?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Statutory Disqualification and Reinstatement Under the Clean Air Act and Clean Water Act § 1532.1115 Can the... person. The EPA also has authority under subparts A through I of 2 CFR part 180, or under 48 CFR part...

  19. cis-Acting sequences in addition to donor and acceptor sites are required for template switching during synthesis of plus-strand DNA for duck hepatitis B virus.

    PubMed Central

    Havert, M B; Loeb, D D

    1997-01-01

    A characteristic of all hepadnaviruses is the relaxed-circular conformation of the DNA genome within an infectious virion. Synthesis of the relaxed-circular genome by reverse transcription requires three template switches. These template switches, as for the template switches or strand transfers of other reverse-transcribing genetic elements, require repeated sequences (the donor and acceptor sites) between which a complementary strand of nucleic acid is transferred. The mechanism for each of the template switches in hepadnaviruses is poorly understood. To determine whether sequences other than the donor and acceptor sites are involved in the template switches of duck hepatitis B virus (DHBV), a series of molecular clones which express viral genomes bearing deletion mutations were analyzed. We found that three regions of the DHBV genome, which are distinct from the donor and acceptor sites, are required for the synthesis of relaxed-circular DNA. One region, located near the 3' end of the minus-strand template, is required for the template switch that circularizes the genome. The other two regions, located in the middle of the genome and near DR2, appear to be required for plus-strand primer translocation. We speculate that these cis-acting sequences may play a role in the organization of the minus-strand DNA template within the capsid particle so that it supports efficient template switching during plus-strand DNA synthesis. PMID:9188603

  20. Clean Air Act Title III accidental emission release risk management program, and how it applies to landfills

    SciTech Connect

    Hibbard, C.S.

    1999-07-01

    On June 20, 1996, EPA promulgated regulations pursuant to Title III of the Clean Air Act (CAA) Amendments of 1990 (Section 112(r)(7) of the CAA). The rule, contained in 40 CFR Part 68, is called Accidental Release Prevention Requirements: Risk Management Programs, and is intended to improve accident prevention and emergency response practices at facilities that store and/or use hazardous substances. Methane is a designated highly hazardous chemical (HHC) under the rule. The rule applies to facilities that have 10,000 pounds of methane or more in any process, roughly equivalent to about 244,000 cubic feet of methane. The US EPA has interpreted this threshold quantity as applying to landfill gas within landfills. This paper presents an overview of the Accidental Release Prevention regulations, and how landfills are affected by the requirements. This paper describes methodologies for calculating the threshold quantity of landfill gas in a landfill. Methane is in landfill gas as a mixture. Because landfill gas can burn readily, down to concentrations of about five percent methane, the entire landfill gas mixture must be treated as the regulated substance, and counts toward the 10,000-pound threshold. It is reasonable to assume that the entire landfill gas collection system, active or passive, is filled with landfill gas, and that a calculation of the volume of the system would be a calculation of the landfill gas present in the process on the site. However, the US EPA has indicated that there are some instances in which pore space gas should be included in this calculation. This paper presents methods available to calculate the amount of pore space gas in a landfill, and how to determine how much of that gas might be available for an explosion. The paper goes through how to conduct the release assessment to determine the worst-case hazard zone around the landfill.

  1. The Implications of ACTS Technology on the Requirements of Rain Attenuation Modeling for Communication System Specification and Analysis at 30/20 GHz and Beyond

    NASA Technical Reports Server (NTRS)

    Manning, Robert M.

    1996-01-01

    The advent of the use of the Ka-Band for space communications, coupled with the introduction of digital modulation techniques as well as multiple-beam methodology for satellites, has deemed it necessary to reassess the plethora of rain attenuation prediction models in use. The Advanced Communication Technology Satellite (ACTS) Project, undertaken by the National Aeronautics and Space Administration in 1983, offered such challenges to rain attenuation prediction modeling. Up to 1983, no such single modeling formalism existed that could fill such requirements. Not even the work done by the NASA Propagation Experimenters (NAPEX) Group had envisioned such requirements, so no dynamic Ka-Band data existed from which one could draw conclusions. In this paper, the basic rudiments of what has become to be known as the 'ACTS Rain Attenuation Prediction Model' will be presented. The concept of rain fade mitigation control availability will be introduced. A new evaluation is then presented for the performance of satellite communication systems, in particular, those to be operating within the Ka-Band and above, that will necessarily employ some type of dynamic rain fade mitigation procedure.

  2. 75 FR 75672 - Proposed Settlement Agreement, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-06

    ... related to the attainment of National Ambient Air Quality Standards (NAAQS) for ozone in the Baton Rouge... regulations for the Baton Rouge area necessary to implement CAA requirements for ozone nonattainment areas... implementation plan addressing certain elements of a severe area 1-hour ozone SIP for Baton Rouge. In 2003,...

  3. Superfund guide: Clean Air Act hazardous air pollutants added to the list of CERCLA hazardous substances. Fact sheet

    SciTech Connect

    Not Available

    1993-09-01

    The fact sheet identifies the 52 CAA hazardous air pollutants that have been added to the list of CERCLA hazardous substances and that are now subject to CERCLA requirements; describes the reporting requirements and exemptions under CERCLA; and examines reporting exemptions in relation to releases of ethylene glycol.

  4. Final Requirements--School Improvement Grants--Title I of the Elementary and Secondary Education Act of 1965. Final Rule. Federal Register, Part IV, Department of Education, 34 CFR Chapter II

    ERIC Educational Resources Information Center

    National Archives and Records Administration, 2015

    2015-01-01

    The Assistant Secretary for Elementary and Secondary Education adopts final requirements for the School Improvement Grants (SIG) program, authorized under section 1003(g) of title I of the Elementary and Secondary Education Act of 1965, as amended (ESEA). These final requirements make changes to the current SIG program requirements and implement…

  5. 2 CFR 1532.1115 - Can the EPA extend a CAA or CWA disqualification to other facilities?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Statutory Disqualification and Reinstatement Under the Clean Air Act and Clean Water Act § 1532.1115 Can the... person. The EPA also has authority under subparts A through I of 2 CFR part 180, or under 48 CFR part...

  6. Meeting the Tobacco Cessation Coverage Requirement of the Patient Protection and Affordable Care Act: State Smoking Cessation Quitlines and Cost Sharing

    PubMed Central

    Bailey, Linda; Leischow, Scott J.

    2015-01-01

    Objectives. We explored whether various key stakeholders considered cost sharing with state telephone-based tobacco cessation quitlines, because including tobacco cessation services as part of the required essential health benefits is a new requirement of the Patient Protection and Affordable Care Act (ACA). Methods. We analyzed qualitative data collected from interviews conducted in April and May of 2014 with representatives of state health departments, quitline service providers, health plans, and insurance brokers in 4 US states. Results. State health departments varied in the strategies they considered the role their state quitline would play in meeting the ACA requirements. Health plans and insurance brokers referred to state quitlines because they were perceived as effective and free, but in 3 of the 4 states, the private stakeholder groups did not consider cost sharing. Conclusions. If state health departments are going to initiate cost-sharing agreements with private insurance providers, then they will need to engage a broad array of stakeholders and will need to overcome the perception that state quitline services are free. PMID:26447918

  7. The Slicer Activity of ARGONAUTE1 Is Required Specifically for the Phasing, Not Production, of Trans-Acting Short Interfering RNAs in Arabidopsis[OPEN

    PubMed Central

    Marchais, Antonin; Poulsen, Christian; Hauptmann, Judith; Meister, Gunter

    2016-01-01

    ARGONAUTE1 (AGO1) mediates posttranscriptional silencing by microRNAs (miRNAs) and short interfering RNAS (siRNAs). AGO1-catalyzed RNA cleavage (slicing) represses miRNA targets, but current models also highlight the roles of slicing in formation of siRNAs and siRNA-AGO1 complexes. miRNA-guided slicing is required for biogenesis of phased, trans-acting siRNAs (tasiRNAs), whose cleaved precursor fragments are converted to double-stranded RNA by RNA-dependent RNA polymerase 6 (RDR6). In addition, unwinding of duplex siRNA bound to AGO1 requires passenger strand cleavage in vitro. In this study, we analyze how mutation of four metal ion-coordinating residues of Arabidopsis thaliana AGO1 affects slicer activity in vitro and siRNA function in vivo. We show that while all four residues are required for slicer activity, they do not contribute equally to catalysis. Moreover, passenger strand cleavage is required for assembly of active AGO1-siRNA complexes in vivo, and many AGO1-bound siRNAs are trimmed in the absence of slicer activity. Remarkably, seedlings defective in AGO1 slicer activity produce abundant siRNAs from tasiRNA loci in vivo. These siRNAs depend on RDR6 and SUPPRESSOR OF GENE SILENCING3, but unlike wild-type tasiRNAs, they are unphased. These results demonstrate that slicing is solely required for phase definition of tasiRNAs, and they strongly support recruitment of RDR6 by AGO1 rather than by cleavage fragments. PMID:27354557

  8. Response of the US EPA (Environmental Protection Agency) region 5 states to the nonpoint source reporting requirements of the 1987 Clean Water Act amendments. Technical report

    SciTech Connect

    Hautman, N.

    1988-01-01

    This report attempts to determine the extent of nonpoint source pollution in Region V. The report analyzes and summarizes the nonpoint source and clean lakes reports required under the Clean Water Act amendments of 1987. The reports share common elements such as a focus on agricultural sources and the use of hard data as well as professional judgment. However, they differ in overall design, definitions of key elements, level of analysis, thoroughness, and effectiveness. The summary considers the reports from two aspects: structure and the extent to which they comply with Sec. 319 and U.S. EPA reports as they are constructed. Information in the 305 (b) reports adds to the scope of each state's nonpoint source program and is referred to here. Following the summary is a discussion, accompanied by appropriate tables, of the nonpoint source pollution extent.

  9. Tanker navigation safety standards: Tanker navigation safety research baseline: A study required by section 4111(b)(9) of the Oil Pollution Act of 1990. Final report

    SciTech Connect

    1996-12-31

    The Oil Pollution Act of 1990 directed the Secretary of Transportation to review and incorporate the results of past studies, including studies by the Coast Guard and Office of Technology Assessment (OTA). This literature search and review focuses on materials pertinent to determining or evaluating current and/or `best` practices, and not on the adequacy of current statutes or regulations. In addition, it is not the intention of the report to assess best practices (e.g., suggest the appropriate crew sizes or what navigation equipment should be required on tankers), but to establish the baseline for future study of best practices. The report does not provide answers to new analytical quations, but presents the status of research so that questions addressed previoulsy will not be duplicated by future studies.

  10. cis-Acting sequences required for expression of the divergently transcribed Drosophila melanogaster Sgs-7 and Sgs-8 glue protein genes

    SciTech Connect

    Hofmann, A.; Garfinkel, M.D.; Meyerowitz, E.M. )

    1991-06-01

    The Sgs-7 and Sgs-8 glue genes at 68C are divergently transcribed and are separated by 475 bp. Fusion genes with Adh or lacZ coding sequences were constructed, and the expression of these genes, with different amounts of upstream sequences present, was tested by a transient expression procedure and by germ line transformation. A cis-acting element for both genes is located asymmetrically in the intergenic region between {minus}211 and {minus}43 bp relative to Sgs-7. It is required for correct expression of both genes. This element can confer the stage- and tissue-specific expression pattern of glue genes on a heterologous promoter. An 86-bp portion of the element, from {minus}133 to {minus}48 bp relative to Sgs-7, is shown to be capable of enhancing the expression of a truncated and therefore weakly expressed Sgs-3 fusion gene. Recently described common sequence motifs of glue gene regulatory elements.

  11. Requiring E-VERIFI Act

    THOMAS, 113th Congress

    Sen. Coburn, Tom [R-OK

    2013-08-01

    08/01/2013 Read twice and referred to the Committee on Finance. (All Actions) Notes: For further action, see H.R.2775, which became Public Law 113-46 on 10/17/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  12. Guidance for federal facilities on release notification requirements under CERCLA and SARA Title 3

    SciTech Connect

    Not Available

    1990-11-01

    The Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA or Superfund''), as amended, creates a framework for Federal involvement in response to and cleanup of hazardous substance releases. Although many of its provisions deal with cleanup, liability, and compensation associated with inactive or abandoned hazardous waste sites, equally important parts of CERCLA address the reporting of and response to releases of hazardous substances as they occur. The statute establishes a list of hazardous substances,'' of which there are currently 727. The CERCLA list contains hazardous substances identified under other statutes, including the Clean Water Act (CWS), the Clean Air Act (CAA), and the Resource Conservation and Recovery Act (RCRA). CERCLA also contains a provision authorizing the Administrator of the US Environmental Protection Agency (EPA) to add substances to the list that when released into the environment may present substantial danger to the public health or welfare or the environment...'' EPA is providing this guidance document so that Federal facilities may better understand the CERCLA and SARA Title 3 release notification requirements. The information is presented in a variety of formats, including questions and answers, fact sheets, scenarios, and a flowchart. A glossary of key terms also has been included in this document. 5 figs.

  13. State of competition in gasoline marketing. The effects of refiner operation at retail (a study required by Title III of the Petroleum Marketing Practices Act)

    SciTech Connect

    Delaney, J.B.; Fenili, R.N.

    1980-05-01

    Title III of the Petroleum Marketing Practices Act requires the Secretary of Energy to report to the Congress on the extent to which producers, refiners, and other suppliers of motor fuel subsidize the sale of such fuel at retail or wholesale with profits obtained from other operations. This is Part I of the report required under that Title. It addresses a number of questions relating to the central issue - the state of competition in the gasoline marketing industry. Part II of the report, to be issued this fall, will discuss the subpoenaed documents of nine integrated companies, and will contain recommendations for action, if deemed necessary. The basic thrust of Part I is an examination of three issues: (1) Are integrated refiners subsidizing their company operated gasoline retail outlets; (2) Are integrated refiners moving gasoline away from their branded dealer network into their own retail outlets; and (3) Are integrated refiners manipulating the allocation system in favor of their own retail outlets to the detriment of other gasoline marketers. At a series of regional hearings, independent marketers charged that integrated refiners were engaging in each of these practices. In essence, integrated refiners were portrayed as using unfair or illegal competitive practices which would ultimately lead to their domination of retail gasoline markets. This report addresses each allegation, after providing a historical and theoretical framework for today's debate.

  14. 36 CFR 801.6 - Coordination with requirements under the National Environmental Policy Act (42 U.S.C. 4321 et seq.).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... final EIS should reflect the results of this process. Applicants are directed to 36 CFR 800.9, which... under the National Environmental Policy Act (42 U.S.C. 4321 et seq.). 801.6 Section 801.6 Parks, Forests... Environmental Policy Act (42 U.S.C. 4321 et seq.). The National Historic Preservation Act and the...

  15. Requirement of multiple cis-acting elements in the human cytomegalovirus major immediate-early distal enhancer for viral gene expression and replication.

    PubMed

    Meier, Jeffery L; Keller, Michael J; McCoy, James J

    2002-01-01

    We have shown previously that the human cytomegalovirus (HCMV) major immediate-early (MIE) distal enhancer is needed for MIE promoter-dependent transcription and viral replication at low multiplicities of infection (MOI). To understand how this region works, we constructed and analyzed a series of HCMVs with various distal enhancer mutations. We show that the distal enhancer is composed of at least two parts that function independently to coordinately activate MIE promoter-dependent transcription and viral replication. One such part is contained in a 47-bp segment that has consensus binding sites for CREB/ATF, SP1, and YY1. At low MOI, these working parts likely function in cis to directly activate MIE gene expression, thus allowing viral replication to ensue. Three findings support the view that these working parts are likely cis-acting elements. (i) Deletion of either part of a bisegmented distal enhancer only slightly alters MIE gene transcription and viral replication. (ii) Reversing the distal enhancer's orientation largely preserves MIE gene transcription and viral replication. (iii) Placement of stop codons at -300 or -345 in all reading frames does not impair MIE gene transcription and viral replication. Lastly, we show that these working parts are dispensable at high MOI, partly because of compensatory stimulation of MIE promoter activity and viral replication that is induced by a virion-associated component(s) present at a high viral particle/cell ratio. We conclude that the distal enhancer is a complex multicomponent cis-acting region that is required to augment both MIE promoter-dependent transcription and HCMV replication.

  16. 77 FR 16785 - Approval and Promulgation of Implementation Plans; Alaska: Infrastructure Requirements for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-22

    ..., which includes requirements for PSD programs to treat nitrogen oxides as a precursor to ozone (72 FR... previously approved by EPA on October 15, 2008 (73 FR 60955). EPA is proposing to concurrently approve a....12 parts per million (ppm) to 0.08 ppm (62 FR 38856). The CAA requires SIPs meeting the...

  17. 77 FR 6044 - Approval and Promulgation of Implementation Plans; Oregon: Infrastructure Requirements for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ... on June 9, 2011 (76 FR 33650), July 5, 2011 (76 FR 38997), and November 9, 2011 (76 FR 80747). II...) to 0.08 ppm (62 FR 38856). The CAA requires SIPs meeting the requirements of sections 110(a)(1) and... these NAAQS by any other state (prong 2) (76 FR 33650). Subsequently, on July 5, 2011, EPA...

  18. Deeming Tobacco Products To Be Subject to the Federal Food, Drug, and Cosmetic Act, as Amended by the Family Smoking Prevention and Tobacco Control Act; Restrictions on the Sale and Distribution of Tobacco Products and Required Warning Statements for Tobacco Products. Final rule.

    PubMed

    2016-05-10

    The Food and Drug Administration (FDA) is issuing this final rule to deem products meeting the statutory definition of "tobacco product,'' except accessories of the newly deemed tobacco products, to be subject to the Federal Food, Drug, and Cosmetic Act (the FD&C Act), as amended by the Family Smoking Prevention and Tobacco Control Act (Tobacco Control Act). The Tobacco Control Act provides FDA authority to regulate cigarettes, cigarette tobacco, roll-your-own tobacco, smokeless tobacco, and any other tobacco products that the Agency by regulation deems to be subject to the law. With this final rule, FDA is extending the Agency's "tobacco product'' authorities in the FD&C Act to all other categories of products that meet the statutory definition of "tobacco product" in the FD&C Act, except accessories of such newly deemed tobacco products. This final rule also prohibits the sale of "covered tobacco products" to individuals under the age of 18 and requires the display of health warnings on cigarette tobacco, roll-your own tobacco, and covered tobacco product packages and in advertisements. FDA is taking this action to reduce the death and disease from tobacco products. In accordance with the Tobacco Control Act, we consider and intend the extension of our authorities over tobacco products and the various requirements and prohibitions established by this rule to be severable. PMID:27192730

  19. Deeming Tobacco Products To Be Subject to the Federal Food, Drug, and Cosmetic Act, as Amended by the Family Smoking Prevention and Tobacco Control Act; Restrictions on the Sale and Distribution of Tobacco Products and Required Warning Statements for Tobacco Products. Final rule.

    PubMed

    2016-05-10

    The Food and Drug Administration (FDA) is issuing this final rule to deem products meeting the statutory definition of "tobacco product,'' except accessories of the newly deemed tobacco products, to be subject to the Federal Food, Drug, and Cosmetic Act (the FD&C Act), as amended by the Family Smoking Prevention and Tobacco Control Act (Tobacco Control Act). The Tobacco Control Act provides FDA authority to regulate cigarettes, cigarette tobacco, roll-your-own tobacco, smokeless tobacco, and any other tobacco products that the Agency by regulation deems to be subject to the law. With this final rule, FDA is extending the Agency's "tobacco product'' authorities in the FD&C Act to all other categories of products that meet the statutory definition of "tobacco product" in the FD&C Act, except accessories of such newly deemed tobacco products. This final rule also prohibits the sale of "covered tobacco products" to individuals under the age of 18 and requires the display of health warnings on cigarette tobacco, roll-your own tobacco, and covered tobacco product packages and in advertisements. FDA is taking this action to reduce the death and disease from tobacco products. In accordance with the Tobacco Control Act, we consider and intend the extension of our authorities over tobacco products and the various requirements and prohibitions established by this rule to be severable.

  20. RIG-I is required for VSV-induced cytokine production by murine glia and acts in combination with DAI to initiate responses to HSV-1.

    PubMed

    Crill, Emma K; Furr-Rogers, Samantha R; Marriott, Ian

    2015-12-01

    A defining feature of viral central nervous system (CNS) infection is the rapid onset of severe neuroinflammation. However, the mechanisms underlying glial responses to replicative neurotropic viruses are only now becoming apparent with the discovery of a number of cytosolic sensors for viral nucleic acids. We have described the expression by murine and human glial cells of two disparate pattern recognition receptors, retinoic acid inducible gene-I (RIG-I) and DNA-dependent activator of interferon regulatory factors (DAI), receptors for viral RNA and DNA moieties, respectively. In the present study, we demonstrate the functional significance of RIG-I expression in primary murine microglia and astrocytes. Our data indicate that murine glial immune responses to a model neurotropic RNA virus, vesicular stomatitis virus, are RIG-I dependent and independent of levels of DAI expression or RNA polymerase III activity. In contrast, maximal glial inflammatory and antiviral responses to the DNA virus herpes simplex virus-1 (HSV-1) are dependent on the expression of both RIG-I and DAI, and require RNA polymerase III activity. These findings indicate that the RNA sensor, RIG-I, acts in parallel with DAI in an RNA polymerase III-dependent manner to initiate glial responses to HSV-1. We therefore suggest that RIG-I plays a significant role in the detection of both RNA and DNA pathogens by microglia and astrocytes.

  1. ACT and College Success

    ERIC Educational Resources Information Center

    Bleyaert, Barbara

    2010-01-01

    What is the relationship between ACT scores and success in college? For decades, admissions policies in colleges and universities across the country have required applicants to submit scores from a college entrance exam, most typically the ACT (American College Testing) or SAT (Scholastic Aptitude Test). This requirement suggests that high school…

  2. 48 CFR 52.225-23 - Required Use of American Iron, Steel, and Manufactured Goods-Buy American Act-Construction...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Principe, Senegal, Sierra Leone, Solomon Islands, Somalia, Tanzania, Togo, Tuvalu, Uganda, Vanuatu, Yemen..., Tuvalu, Uganda, Vanuatu, Yemen, or Zambia). Recovery Act designated country construction material means...

  3. Determination of upstream boundary points on southeastern Washington streams and rivers under the requirements of the Shoreline Management Act of 1971

    USGS Publications Warehouse

    Higgins, Johnna L.

    2003-01-01

    Regulation of the shorelines of the State of Washington, as mandated by the Shoreline Management Act of 1971, requires knowledge of the locations on streams and river reaches where specific regulatory criteria are satisfied. The U.S. Geological Survey conducted a study in 1971 to determine the upstream boundary points of these reaches for many of the State's streams and rivers. Updated upstream boundary points were determined in the current study for all the streams and rivers in southeastern Washington that fall under the jurisdiction of the Shoreline Management Act of 1971. Upstream boundary point locations where the mean annual discharge equals 20 cubic feet per second were determined for 149 streams. In addition, upstream boundary point locations where the mean annual discharge equals 200 cubic feet per second or the drainage area equals 300 square miles were determined for 22 rivers. Boundary point locations were determined by application of multiple-linear-regression equations that relate mean annual discharge to drainage area and mean annual precipitation. Southeastern Washington was divided into five hydrologically distinct regions, and a separate regression equation was developed for each region. The regression equations are based on data for gaging stations with at least 10 years of record. The number of stations in the regression analysis for each of the five regions ranged from 5 to 33. The coefficient of determination, R2, of the regression equations ranged from 0.953 to 0.997. The equation for the Upper Yakima region had the lowest standard error, ranging from -7 to +9 percent for a regression estimate of 20 cubic feet per second. The equation for the Columbia Basin to Palouse region had the highest standard error, ranging from -36 to +55 percent for a regression estimate of 20 cubic feet per second. The approximate error in the location of an upstream boundary point can be calculated using the variables mean annual precipitation of the basin upstream

  4. Characterization of the complete mitochondrial genome of the Grey-backed Shrike, Lanius tephronotus (Aves: Passeriformes): the first representative of the family Laniidae with a novel CAA stop codon at the end of cox2 gene.

    PubMed

    Qian, Chaoju; Yan, Xia; Guo, Zhichun; Wang, Yuanxiu; Li, Xixi; Yang, Jianke; Kan, Xianzhao

    2013-08-01

    The complete Grey-backed Shrike mitochondrial genome has been sequenced to be 16,820 bp in length, consisting of 37 encode genes: 13 protein-coding genes, 2 ribosomal RNA genes, and 22 transfer RNA genes. In addition, a single control region was also observed. Compared with other reported Passeriformes mtgenome sequences, three bases CAA were detected at the end of Lanius tephronotus cox2 gene with the downstream adjacent base T. The first base of CAA probably occurred C to U transcript editing event resulting in a normal stop codon UAA.

  5. SCANS and the "Goals 2,000: Educate America Act"--External Validation for Expanding Communication Instruction Requirements across the Undergraduate Core Curriculum.

    ERIC Educational Resources Information Center

    Newburger, Craig

    In 1989, President George Bush met with the nation's governors and the foundation was laid for the "Goals 2000: Educate America Act" (signed into law March 1994). The act provides funds to underwrite states' development and implementation of content and performance standards and associated assessment methodologies directed toward helping students…

  6. Overcoming Geometry-Induced Stiffness with IMplicit-Explicit (IMEX) Runge-Kutta Algorithms on Unstructured Grids with Applications to CEM, CFD, and CAA

    NASA Technical Reports Server (NTRS)

    Kanevsky, Alex

    2004-01-01

    My goal is to develop and implement efficient, accurate, and robust Implicit-Explicit Runge-Kutta (IMEX RK) methods [9] for overcoming geometry-induced stiffness with applications to computational electromagnetics (CEM), computational fluid dynamics (CFD) and computational aeroacoustics (CAA). IMEX algorithms solve the non-stiff portions of the domain using explicit methods, and isolate and solve the more expensive stiff portions using implicit methods. Current algorithms in CEM can only simulate purely harmonic (up to lOGHz plane wave) EM scattering by fighter aircraft, which are assumed to be pure metallic shells, and cannot handle the inclusion of coatings, penetration into and radiation out of the aircraft. Efficient MEX RK methods could potentially increase current CEM capabilities by 1-2 orders of magnitude, allowing scientists and engineers to attack more challenging and realistic problems.

  7. Medicare Program; Temporary Exception for Certain Severe Wound Discharges From Certain Long-Term Care Hospitals Required by the Consolidated Appropriations Act, 2016; Modification of Limitations on Redesignation by the Medicare Geographic Classification Review Board. Interim final rule with comment period.

    PubMed

    2016-04-21

    This interim final rule with comment period (IFC) implements section 231 of the Consolidated Appropriations Act of 2016 (CAA), which provides for a temporary exception for certain wound care discharges from the application of the site neutral payment rate under the Long-Term Care Hospital (LTCH) Prospective Payment System (PPS) for certain long-term care hospitals. This IFC also amends our current regulations to allow hospitals nationwide to reclassify based on their acquired rural status, effective with reclassifications beginning with fiscal year (FY) 2018. Hospitals with an existing Medicare Geographic Classification Review Board (MGCRB) reclassification would also have the opportunity to seek rural reclassification for IPPS payment and other purposes and keep their existing MGCRB reclassification. We would also apply the policy in this IFC when deciding timely appeals before the Administrator under our regulations for FY 2017 that were denied by the MGCRB due to existing regulations, which do not permit simultaneous rural reclassification for IPPS payment and other purposes and MGCRB reclassification. These regulatory changes implement the decisions in Geisinger Community Medical Center v. Secretary, United States Department of Health and Human Services, 794 F.3d 383 (3d Cir. 2015) and Lawrence + Memorial Hospital v. Burwell, No. 15-164, 2016 WL 423702 (2d Cir. Feb. 4, 2015) in a nationally consistent manner.

  8. Medicare Program; Temporary Exception for Certain Severe Wound Discharges From Certain Long-Term Care Hospitals Required by the Consolidated Appropriations Act, 2016; Modification of Limitations on Redesignation by the Medicare Geographic Classification Review Board. Interim final rule with comment period.

    PubMed

    2016-04-21

    This interim final rule with comment period (IFC) implements section 231 of the Consolidated Appropriations Act of 2016 (CAA), which provides for a temporary exception for certain wound care discharges from the application of the site neutral payment rate under the Long-Term Care Hospital (LTCH) Prospective Payment System (PPS) for certain long-term care hospitals. This IFC also amends our current regulations to allow hospitals nationwide to reclassify based on their acquired rural status, effective with reclassifications beginning with fiscal year (FY) 2018. Hospitals with an existing Medicare Geographic Classification Review Board (MGCRB) reclassification would also have the opportunity to seek rural reclassification for IPPS payment and other purposes and keep their existing MGCRB reclassification. We would also apply the policy in this IFC when deciding timely appeals before the Administrator under our regulations for FY 2017 that were denied by the MGCRB due to existing regulations, which do not permit simultaneous rural reclassification for IPPS payment and other purposes and MGCRB reclassification. These regulatory changes implement the decisions in Geisinger Community Medical Center v. Secretary, United States Department of Health and Human Services, 794 F.3d 383 (3d Cir. 2015) and Lawrence + Memorial Hospital v. Burwell, No. 15-164, 2016 WL 423702 (2d Cir. Feb. 4, 2015) in a nationally consistent manner. PMID:27101642

  9. 75 FR 64773 - Study Required by Section 989G(b) of the Dodd-Frank Act Regarding Compliance With Section 404(b...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-20

    ... Exchange Act Rule 12b-2 . \\4\\ See, e.g., Release No. 33-9072 (Oct. 13, 2009) [74 FR 53628]; and Release 33... on risk and materiality, scalability, tailoring of testing to risk, and extent of permitted use...

  10. Elementary and Secondary Education Act: Potential Effects of Changing Comparability Requirements. Report to the Chairman, Committee on Health, Education, Labor, and Pensions, U.S. Senate. GAO-11-258

    ERIC Educational Resources Information Center

    Scott, George A.

    2011-01-01

    For fiscal year 2010, Congress appropriated $14.5 billion for Title I, Part A of the Elementary and Secondary Education Act of 1965 (ESEA), which funds services to students in schools with high concentrations of students from low-income families. Title I, Part A includes several fiscal requirements, which are designed to prevent local school…

  11. 78 FR 46549 - Approval and Promulgation of Implementation Plans; Idaho: State Board Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-01

    ... four (4) members of the board shall be from any one (1) political party. Two (2) members of the board... period, and the level of the NAAQS was changed from 0.12 parts per million (ppm) to 0.08 ppm (62 FR 38856... submittal to satisfy the requirements of CAA section 110(a)(2) for the 1997 ozone NAAQS (73 FR 16205)....

  12. 78 FR 46514 - Approval and Promulgation of Implementation Plans; Oregon: Infrastructure Requirements for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-01

    ... provisions of the Oregon SIP are adequate to satisfy the above-mentioned infrastructure elements required by..., 2008 (78 FR 17304). In our March 21, 2013, notice of proposed rulemaking (NPR), we proposed to approve... meet the following CAA section 110(a)(2) infrastructure elements for the 1997 PM 2.5 , 2006 PM...

  13. 78 FR 63394 - Approval and Promulgation of Implementation Plans; Idaho: State Board Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-24

    .... Statutory and Executive Order Reviews I. Background On July 16, 2013, the State of Idaho submitted a SIP... approval of the July 16, 2013, draft SIP revision (78 FR 46549). An explanation of the CAA requirements and... Executive Order 13132 (64 FR 43255, August 10, 1999); is not an economically significant regulatory...

  14. 78 FR 17304 - Approval and Promulgation of Implementation Plans; Oregon: Infrastructure Requirements for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-21

    ... and with any disk or CD-ROM you submit. If the EPA cannot read your ] comment due to technical... approved on May 21, 2012 (77 FR 29904). This action also does not address the requirements of CAA section... separate actions on June 9, 2011 (76 FR 33650), July 5, 2011 (76 FR 38997), and December 27, 2011 (76...

  15. Title III list of lists: Consolidated list of chemicals subject to the Emergency Planning and Community Right-to-Know Act (EPCRA) and section 112(r) of the Clean Air Act, as ammended. Title III of the Superfund Amendments and Reauthorization Act of 1986, and Title III of the Clean Air Act Amendments of 1990, April 1995

    SciTech Connect

    1995-04-01

    This consolidated list has been prepared to help firms handling chemicals determine whether they need to submit reports under sections 302, 304, or 313 of SARA Title III (EPCRA) and, for a specific chemical, what reports may need to be submitted. It will also help firms determine whether they will be subject to accident prevention regulations under CAA section 112(r). Separate lists are also provided of Resource Conservation and Recovery Act (RCRA) waste streams and unlisted hazardous wastes, and of radionuclides reportable under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). These lists should be used as a reference tool, not as a definitive source of compliance information.

  16. Americans with Disabilities Act.

    ERIC Educational Resources Information Center

    Updating School Board Policies, 1992

    1992-01-01

    Addressed to school board members, this article attempts to summarize requirements of the Americans with Disabilities Act (ADA) and its implications for school districts. It warns against hasty purchase of private compliance assistance; then provides an overview of each of the Act's five Titles which address employment practices, activities…

  17. DEVELOPMENT OF WATER SUPPLY TECHNOLOGY TO MEET THE REQUIREMENTS OF THE U.S. SAFE DRINKING WATER ACT: TRENDS AND PROSPECTS

    EPA Science Inventory

    the passage of the US SDWA in 1974 has had a major impact on the way water is treated and delivered in the US. The Act established national drinking water regulations for more than 170,000 public drinking water systems serving over 250 million people in the US. Under the SDWA pub...

  18. A Study of the Experiences of Alternatively Certified Special Education Teachers Related to the Requirements of the No Child Left Behind Act of 2001

    ERIC Educational Resources Information Center

    Veale, Natasha W.

    2010-01-01

    A No Child Left Behind Act of 2001 Title II audit found the state of North Carolina out of compliance with the definition of teacher quality for secondary special education teachers. The state specific Praxis exam and the Highly Objective, Uniform State Standard of Evaluation these teachers completed to earn certification to teach subject area…

  19. Sex Discrimination and Hair-Length Requirements Under Title VII of the Civil Rights Act of 1964 -- the Long and Short of It

    ERIC Educational Resources Information Center

    Golden, H. Bruce

    1974-01-01

    Since the passage of Title VII of the Civil Rights Act of 1964, an employer's rights to establish dress and appearance standards for employees has been challenged with increasing frequency as a discriminatory employment practice based upon sex. The majority of such cases have concerned the right of male employees to wear their hair as long as that…

  20. Who Benefits? The Impact of Alternative Eligibility Requirements for Training Stipends in the Reemployment Act of 1994. Research Report 94-01.

    ERIC Educational Resources Information Center

    National Commission for Employment Policy (DOL), Washington, DC.

    A study used a special supplement of the Current Population Survey to examine the age, race, gender, and income effects of the unemployment eligibility and job tenure provisions in the Reemployment Act of 1994 (REA). Findings indicated that, at most, 45 percent of all dislocated workers would be eligible for income support during training. Because…

  1. EIA's role in the analysis of the Clean Air Act Amendments of 1990 and the development of the National Allowance Database

    SciTech Connect

    Beamon, J.A.; Linders, M.J. )

    1993-01-01

    Throughout 1990 the Energy Information Administration (EIA) provided continuous data and analytic support to Congress during its deliberations on Title IV of the Clean Air Act Amendments of 1990 (CAA). Congress requested the Energy Information Administration (EIA) to review and analyze the sections that would affect electric utilities, specifically those relating to acid deposition (Title IV). By providing knowledgeable and impartial analysis, EIA clarified the likely effects of the various legislative proposals and helped Congress finalize the amendments. Even though the CAA is now law, EIA's efforts have not ended. During the analysis of the various proposals, EIA and EPA created a National Allowance Database (NAD). Now, under an agreement with the Environmental Protection Agency (EPA), a new version of the NAD is being developed to facilitate the implementation of the acid deposition provisions of the CAA. This article describes the analyses undertaken, points out where EIA's efforts led to improved understanding of the likely impacts of the CAA, and outlines EIA's continued efforts to assist EPA in the implementation of the amendments. 6 tabs.

  2. ACT: Acting Out Central Theme.

    ERIC Educational Resources Information Center

    Kise, Joan Duff

    1982-01-01

    The author describes ACT (Acting Out Central Theme), a method for dealing with psychomotor, cognitive, and affective domains in slow readers. The ACT approach involves three sessions which focus on discussion of a theme such as friendship, presentaton of the theme as a skit, and assignment of topics to individual students. (SW)

  3. Act resilient.

    PubMed

    Joseph, Genie; Bice-Stephens, Wynona

    2014-01-01

    Attendees have reported changing from being fearful to serene, from listless to energized, from disengaged to connected, and becoming markedly less anxious in a few weeks. Anecdotally, self-reported stress levels have been reduced by over 50% after just one class. Attendees learn not to be afraid of their feelings by working with emotions in a playful manner. When a person can act angry, but separate himself from his personal story, the emotional energy exists in a separate form that is not attached to specific events, and can be more easily dealt with and neutralized. Attendees are taught to "take out the emotional trash" through expressive comedy. They become less intimated by their own emotional intensity and triggers as they learn how even metaphorical buckets of anger, shame, guilt and hurt can be emotionally emptied. The added benefit is that this is accomplished without the disclosure of personal information of the requirement to reexperience past pain which can trigger its own cascade of stress. PMID:24706248

  4. Modulation of the Inhibitor Properties of Dipeptidyl (Acyloxy)methyl Ketones Toward the CaaX Proteases

    PubMed Central

    Dechert, Anne-Marie R.; MacNamara, James P.; Breevoort, Sarah R.; Hildebrandt, Emily R.; Hembree, Ned W.; Rea, Adam C.; McLain, Duncan E.; Porter, Stephen B.; Schmidt, Walter K.; Dore, Timothy M.

    2010-01-01

    Dipeptidyl (acyloxy)methyl ketones (AOMKs) have been identified as mechanism-based inhibitors of certain cysteine proteases. These compounds are also inhibitors of the integral membrane proteins Rce1p and Ste24p, which are proteases that independently mediate a cleavage step associated with the maturation of certain isoprenylated proteins. The enzymatic mechanism of Rce1p is ill-defined, whereas Ste24p is a zinc metalloprotease. Rce1p is required for the proper processing of the oncoprotein Ras and is viewed as a potential target for cancer therapy. In this study, we synthesized a small library of dipeptidyl AOMKs to investigate the structural elements that contribute to the inhibitor properties of this class of molecules toward Rce1p and Ste24p. The compounds were evaluated using a fluorescence-based in vitro proteolysis assay. The most potent dipeptidyl AOMKs contained an arginine residue and the identity of the benzoate group strongly influenced potency. A “warhead” free AOMK inhibited Rce1p and Ste24p. The data suggest that the dipeptidyl AOMKs are not mechanism-based inhibitors of Rce1p and Ste24p and corroborate the hypothesis that Rce1p is not a cysteine protease. PMID:20696584

  5. The Clean Air Act Amendments of 1990 and industry; Title I non-attainment areas

    SciTech Connect

    Saunders, G.L. ); Laznow, J. )

    1991-10-01

    The signing into law of the CAA Amendments of 1990 will bring sweeping changes affecting significantly the way industry is regulated. This paper reports that the Amendments address a wide range of issues, including non- attainment areas, toxic air pollutants, acid rain, operating permits and fees, and regulatory enforcement. Regulations to be promulgated under the Amendments will stand in stark contrast to those promulgated after CAA was last amended in 1977. Many of the issues addressed by the 1990 Amendments have accumulated for years, waiting for legislation consideration. Title I of the Amendments sets National Ambient Air Quality Standards (NAAQS) for several criteria pollutants. The standard for ozone is of greatest general interest for stationary sources, along with requirements for control of nitrogen oxides (NO{sub x}) and VOCs.

  6. Hoxb-2 transcriptional activation in rhombomeres 3 and 5 requires an evolutionarily conserved cis-acting element in addition to the Krox-20 binding site.

    PubMed Central

    Vesque, C; Maconochie, M; Nonchev, S; Ariza-McNaughton, L; Kuroiwa, A; Charnay, P; Krumlauf, R

    1996-01-01

    Segmentation is a key feature of the development of the vertebrate hindbrain where it involves the generation of repetitive morphological units termed rhombomeres (r). Hox genes are likely to play an essential role in the specification of segmental identity and we have been investigating their regulation. We show here that the mouse and chicken Hoxb-2 genes are dependent for their expression in r3 and r5 on homologous enhancer elements and on binding to this enhancer of the r3/r5-specific transcriptional activator Krox-20. Among the three Krox-20 binding sites of the mouse Hoxb-2 enhancer, only the high-affinity site is absolutely necessary for activity. In contrast, we have identified an additional cis-acting element, Box1, essential for r3/r5 enhancer activity. It is conserved both in sequence and in position respective to the high-affinity Krox-20 binding site within the mouse and chicken enhancers. Furthermore, a short 44 bp sequence spanning the Box1 and Krox-20 sites can act as an r3/r5 enhancer when oligomerized. Box1 may therefore constitute a recognition sequence for another factor cooperating with Krox-20. Taken together, these data demonstrate the conservation of Hox gene regulation and of Krox-20 function during vertebrate evolution. Images PMID:8895582

  7. Juggling Act

    ERIC Educational Resources Information Center

    Rudalevige, Andrew

    2009-01-01

    Two education bills from George W. Bush's first term are long overdue for reauthorization. One, of course, is the No Child Left Behind Act (NCLB), passed in late 2001. The other is the Education Sciences Reform Act (ESRA), which in November 2002 replaced the Office of Educational Research and Improvement (OERI) with a new Institute of Education…

  8. Applying the Clean Air Act to municipal solid waste landfills

    SciTech Connect

    Heitz, D.R.; Romzick, P.G.

    1998-12-31

    On March 12, 1996, the EPA promulgated the new Source Performance Standards (NSPS) for Municipal Solid Waste (MSW) Landfills, the first federal air regulation specifically for MSW landfills. Landfills subject to this regulation which exceeded the threshold design capacity also became subject to the Title V operating permit program. This began the application of the Clean Air Act (CAA) to most of these nontraditional air sources. Unlike landfills, typical air sources have easily defined input capacities that correspond to potential emissions while the process creates a product or output. All these concepts are difficult and confusing to apply to MSW landfills. Applicability of the following CAA regulations are specifically addressed in this paper: NSPS for MSW landfills; new Source Review (NSR)/Prevention of Significant Deterioration (PSD); landfill Maximum Achievable Control Technologies (MACT); 112(g) Modification of Major Sources of Hazardous Air Pollutants (HAP); 112(r) Accidental Release Prevention; and Title V. Along with summarizing the potential applicability of each, the main issues are presented along with the current information on the regulations.

  9. 48 CFR 50.205-1 - SAFETY Act Considerations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Fostering Effective Technologies Act of 2002 50.205-1 SAFETY Act Considerations. (a) SAFETY Act applicability. Requiring activities should review requirements to identify potential technologies that prevent... acquisitions involving such technologies, the requiring activity should ascertain through discussions with...

  10. The Clean Water Act

    SciTech Connect

    Piatt, J.

    1995-12-31

    The Federal Water Pollution Control Act, commonly called the Clean Water Act (CWA), was adopted on 18 October 1972. Since then it has been amended 18 times, the last amendments were adopted on 4 February 1987. As established, its objective is: to restore and maintain the chemical, physical, and biological integrity of the Nation`s waters. And has, as an interim goal: water quality which provides for the protection and propagation of fish, shellfish, and wildlife and provides for recreation in and on the water. It should be noted that Congress established as the Act`s ultimate goal: the discharge of pollutants into the navigable waters be eliminated. The Act set out to meet this lofty objective and goal through the development and implementation of controls on the point source discharges and the nonpoint source release of pollutants. The regulation of point and nonpoint sources as well as future requirements are discussed.

  11. The Impact of the Adequate Yearly Progress Requirement of the Federal "No Child Left Behind" Act on Schools in the Great Lakes Region. Technical Appendix

    ERIC Educational Resources Information Center

    Wiley, Edward W.; Allen, Jessica

    2005-01-01

    This appendix describes the analytical procedures used to project the status of schools in the Great Lakes state toward meeting AYP (Adequate Yearly Progress) requirements from 2005 to 2014. To "make AYP," the school as a whole and each numerically significant subgroup must meet "Annual Measurable Objectives" (annual objectives). States set their…

  12. 20 CFR 652.210 - What are the Act's requirements for administration of the work test and assistance to UI claimants?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... establish the requirements under which UI claimants must register and search for work in order to fulfill... receive the necessary guidance and counseling to ensure they make a meaningful and realistic work search; and (3) UI program staff receive information about UI claimants' ability or availability for work,...

  13. 29 CFR 516.14 - Country elevator employees exempt from overtime pay requirements under section 13(b)(14) of the Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Country elevator employees exempt from overtime pay....14 Country elevator employees exempt from overtime pay requirements under section 13(b)(14) of the... names and occupations of all persons employed in the country elevator, whether or not covered by the...

  14. 29 CFR 516.14 - Country elevator employees exempt from overtime pay requirements under section 13(b)(14) of the Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Country elevator employees exempt from overtime pay....14 Country elevator employees exempt from overtime pay requirements under section 13(b)(14) of the... names and occupations of all persons employed in the country elevator, whether or not covered by the...

  15. ACT Test

    MedlinePlus

    ... this page helpful? Also known as: ACT; Activated Coagulation Time Formal name: Activated Clotting Time Related tests: ... in the blood called platelets and proteins called coagulation factors are activated in a sequence of steps ...

  16. Acting Atoms.

    ERIC Educational Resources Information Center

    Farin, Susan Archie

    1997-01-01

    Describes a fun game in which students act as electrons, protons, and neutrons. This activity is designed to help students develop a concrete understanding of the abstract concept of atomic structure. (DKM)

  17. The application of genetic information for regulatory standard setting under the clean air act: a decision-analytic approach.

    PubMed

    Cullen, Alison C; Corrales, Mark A; Kramer, C Bradley; Faustman, Elaine M

    2008-08-01

    In 2002, the U.S. Environmental Protection Agency (EPA) released an "Interim Policy on Genomics," stating a commitment to developing guidance on the inclusion of genetic information in regulatory decision making. This statement was followed in 2004 by a document exploring the potential implications. Genetic information can play a key role in understanding and quantifying human susceptibility, an essential step in many of the risk assessments used to shape policy. For example, the federal Clean Air Act (CAA) requires EPA to set National Ambient Air Quality Standards (NAAQS) for criteria pollutants at levels to protect even sensitive populations from adverse health effects with an adequate margin of safety. Asthmatics are generally regarded as a sensitive population, yet substantial research gaps in understanding genetic susceptibility and disease have hindered quantitative risk analysis. This case study assesses the potential role of genomic information regarding susceptible populations in the NAAQS process for fine particulate matter (PM(2.5)) under the CAA. In this initial assessment, we model the contribution of a single polymorphism to asthma risk and mortality risk; however, multiple polymorphisms and interactions (gene-gene and gene-environment) are known to play key roles in the disease process. We show that the impact of new information about susceptibility on estimates of population risk or average risk derived from large epidemiological studies depends on the circumstances. We also suggest that analysis of a single polymorphism, or other risk factor such as health status, may or may not change estimates of individual risk enough to alter a particular regulatory decision, but this depends on specific characteristics of the decision and risk information. We also show how new information about susceptibility in the context of the NAAQS for PM(2.5) could have a large impact on the estimated distribution of individual risk. This would occur if a group were

  18. Comparison between Long- and Short-Acting Erythropoiesis-Stimulating Agents in the Period Required for Haemoglobin Stabilisation in Treatment of Anaemia in Patients with Chronic Kidney Disease.

    PubMed

    Hayashi, Takahiro; Nagamatsu, Tadashi; Matsushita, Ayako; Mizuno, Tomohiro; Nishibe, Seira; Noguchi, Ayaka; Kato, Rina; Toda, Takahiro; Tanaka, Junko; Takahashi, Hiroshi; Hayashi, Hiroki; Yuzawa, Yukio; Yamada, Shigeki

    2015-01-01

    Comparative studies of the potency of long- and short-acting erythropoiesis-stimulating agents (L-ESAs and S-ESAs) on erythropoietic activity in patients with chronic kidney disease without dialysis have not been performed, although L-ESAs are used in many countries. We performed a retrospective analysis of non-dialysis (ND) patients who had received L-ESA or S-ESA. More days were needed for the S-ESA-treated group (368 d) to reach the haemoglobin (Hb) reference range than for the L-ESA-treated group (126 d). Therefore, we investigated risk factors that influence the period until the Hb level reaches the reference range. Patients were classified into two groups by the period until the Hb level was stabilised within the reference range: the short- and long-term group. Two risk factors for delayed Hb stabilisation were identified: age ≥60 years; and administration of an S-ESA for initial treatment. These findings suggest that the Hb level should be carefully monitored during ESA therapy in elderly ND patients, and that the ESA dose should be increased or L-ESA therapy should be utilised to treat renal anaemia.

  19. Trefoil factor 3 is required for differentiation of thyroid follicular cells and acts as a context-dependent tumor suppressor.

    PubMed

    Abols, A; Ducena, K; Andrejeva, D; Sadovska, L; Zandberga, E; Vilmanis, J; Narbuts, Z; Tars, J; Eglitis, J; Pirags, V; Line, A

    2015-01-01

    Trefoil factor 3 (TFF3) is overexpressed in a variety of solid epithelial cancers, where it has been shown to promote migration, invasion, proliferation, survival and angiogenesis. On the contrary, in the majority of thyroid tumors, it is downregulated, yet its role in the development of thyroid cancer remains unknown. Here we show that TFF3 exhibits strong cytoplasmic staining of normal thyroid follicular cells and colloid and the staining is increased in hyperfunctioning thyroid nodules, while it is decreased in all thyroid cancers of follicular cell origin. By meta-analysis of gene expression datasets, we found that in the thyroid cancer, conversely to the breast cancer, the expression of TFF3 mRNA was downregulated by estrogen signaling and confirmed this by treating thyroid cancer cells with estradiol. Forced expression of TFF3 in anaplastic thyroid cancer cells resulted in decreased cell proliferation, clonal spheroid formation and entry into the S phase. Furthermore, it induced acquisition of epithelial-like cell morphology and expression of the differentiation markers of thyroid follicular cells and transcription factors implicated in the thyroid morphogenesis and function. Taken together, this study provides the first evidence that TFF3 may act as a tumor suppressor or an oncogene depending on the cellular context.

  20. Functional dissection of the cis-acting sequences of the Arabidopsis transposable element Tag1 reveals dissimilar subterminal sequence and minimal spacing requirements for transposition.

    PubMed Central

    Liu, D; Mack, A; Wang, R; Galli, M; Belk, J; Ketpura, N I; Crawford, N M

    2001-01-01

    The Arabidopsis transposon Tag1 has an unusual subterminal structure containing four sets of dissimilar repeats: one set near the 5' end and three near the 3' end. To determine sequence requirements for efficient and regulated transposition, deletion derivatives of Tag1 were tested in Arabidopsis plants. These tests showed that a 98-bp 5' fragment containing the 22-bp inverted repeat and four copies of the AAACCX (X = C, A, G) 5' subterminal repeat is sufficient for transposition while a 52-bp 5' fragment containing only one copy of the subterminal repeat is not. At the 3' end, a 109-bp fragment containing four copies of the most 3' repeat TGACCC, but not a 55-bp fragment, which has no copies of the subterminal repeats, is sufficient for transposition. The 5' and 3' end fragments are not functionally interchangeable and require an internal spacer DNA of minimal length between 238 and 325 bp to be active. Elements with these minimal requirements show transposition rates and developmental control of excision that are comparable to the autonomous Tag1 element. Last, a DNA-binding activity that interacts with the 3' 109-bp fragment but not the 5' 98-bp fragment of Tag1 was found in nuclear extracts of Arabidopsis plants devoid of Tag1. PMID:11156999

  1. 77 FR 62452 - Approval and Promulgation of Implementation Plans; State of Arizona; Prevention of Air Pollution...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ... Air Pollution Emergency Episodes AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule... address the requirements regarding air pollution emergency episodes in Clean Air Act (CAA or Act). DATES... Arizona to address the requirements regarding air pollution emergency episodes in CAA section...

  2. Proactive industrial strategies for the Clean Air Act Amendments of 1990.

    PubMed

    Ruch, R B; Howell, J S

    1991-07-01

    The Clean Air Act (CAA) Amendments of 1990 was signed into law by President Bush on November 15, 1990. These amendments potentially will have a major impact on virtually every industrial and many commercial facilities throughout the country. The regulations developed to implement this legislation will encompass new approaches to nonattainment, air toxics, accidental releases, acid rain, permits and enforcement. Because of the impact of this legislation the regulations will be implemented over a ten-year period. This paper is an overview of the amendments and recommended proactive strategies for industry.

  3. cis-Acting Sequences Required for NtcB-Dependent, Nitrite-Responsive Positive Regulation of the Nitrate Assimilation Operon in the Cyanobacterium Synechococcus sp. Strain PCC 7942

    PubMed Central

    Maeda, Shin-Ichi; Kawaguchi, Yuriko; Ohe, Taka-Aki; Omata, Tatsuo

    1998-01-01

    There are three binding sites for NtcA (nirI, nirII, and nirIII), the global nitrogen regulator of cyanobacteria, in the DNA region between the two divergently transcribed operons (nirA and nirB operons) involved in nitrate assimilation in Synechococcus sp. strain PCC 7942. Using the luxAB reporter system, we showed that nirI and nirIII, which are located 23 bp upstream from the −10 promoter element of nirA and nirB, respectively, are required for induction by nitrogen depletion of the nirA and nirB operons, respectively. The induction of nirA operon transcription was a prerequisite for the nitrite-responsive positive regulation of the transcription by NtcB, a LysR-type protein. The NtcA-binding site nirII, located in the middle of the nirA-nirB intergenic region, and a potential binding site for a LysR-type protein (TGCAN5TGCA; designated L1), located between nirI and nirII, were required for the nitrite-responsive, NtcB-dependent enhancement of nirA operon transcription. Although the requirement for the L1 site was consistent with the involvement of the LysR family protein NtcB in transcriptional regulation, NtcB did not bind to the nirA regulatory region in vitro in the presence of nitrite and NtcA, suggesting the involvement of some additional factor(s) in the regulation. An L1-like inverted repeat with the consensus sequence TGCN7GCA was conserved in the nirA promoter region of cyanobacteria, being centered at position −23 with respect to the NtcA-binding site corresponding to nirI, which suggested the common occurrence of nitrite-responsive regulation of the nitrate assimilation operon among cyanobacteria. PMID:9696753

  4. SRC2-1 is required in PcINF1-induced pepper immunity by acting as an interacting partner of PcINF1.

    PubMed

    Liu, Zhi-qin; Qiu, Ai-lian; Shi, Lan-ping; Cai, Jin-sen; Huang, Xue-ying; Yang, Sheng; Wang, Bo; Shen, Lei; Huang, Mu-kun; Mou, Shao-liang; Ma, Xiao-Ling; Liu, Yan-yan; Lin, Lin; Wen, Jia-yu; Tang, Qian; Shi, Wei; Guan, De-yi; Lai, Yan; He, Shui-lin

    2015-07-01

    Elicitins are elicitors that can trigger hypersensitive cell death in most Nicotiana spp., but their underlying molecular mechanism is not well understood. The gene Phytophthora capsici INF1 (PcINF1) coding for an elicitin from P. capsici was characterized in this study. Transient overexpression of PcINF1 triggered cell death in pepper (Capsicum annuum L.) and was accompanied by upregulation of the hypersensitive response marker, Hypersensitive Induced Reaction gene 1 (HIR1), and the pathogenesis-related genes SAR82, DEF1, BPR1, and PO2. A putative PcINF1-interacting protein, SRC2-1, was isolated from a pepper cDNA library by yeast two-hybrid screening and was observed to target the plasma membrane. The interaction between PcINF1 and SRC2-1 was confirmed by bimolecular fluorescence complementation and co-immunoprecipitation. Simultaneous transient overexpression of SRC2-1 and PcINF1 in pepper plants triggered intensive cell death, whereas silencing of SRC2-1 by virus-induced gene silencing blocked the cell death induction of PcINF1 and increased the susceptibility of pepper plants to P. capsici infection. Additionally, membrane targeting of the PcINF1-SRC2-1 complex was required for cell death induction. The C2 domain of SRC2-1 was crucial for SRC2-1 plasma membrane targeting and the PcINF1-SRC2-1 interaction. These results suggest that SRC2-1 interacts with PcINF1 and is required in PcINF1-induced pepper immunity.

  5. National School Lunch Program and School Breakfast Program: Nutrition Standards for All Foods Sold in School as Required by the Healthy, Hunger-Free Kids Act of 2010. Final rule and interim final rule.

    PubMed

    2016-07-29

    This rule adopts as final, with some modifications, the National School Lunch Program and School Breakfast Program regulations set forth in the interim final rule published in the Federal Register on June 28, 2013. The requirements addressed in this rule conform to the provisions in the Healthy, Hunger-Free Kids Act of 2010 regarding nutrition standards for all foods sold in schools, other than food sold under the lunch and breakfast programs. Most provisions of this final rule were implemented on July 1, 2014, a full year subsequent to publication of the interim final rule. This was in compliance with section 208 of the Healthy, Hunger-Free Kids Act of 2010, which required that State and local educational agencies have at least one full school year from the date of publication of the interim final rule to implement the competitive food provisions. Based on comments received on the interim final rule and implementation experience, this final rule makes a few modifications to the nutrition standards for all foods sold in schools implemented on July 1, 2014. In addition, this final rule codifies specific policy guidance issued after publication of the interim rule. Finally, this rule retains the provision related to the standard for total fat as interim and requests further comment on this single standard.

  6. National School Lunch Program and School Breakfast Program: Nutrition Standards for All Foods Sold in School as Required by the Healthy, Hunger-Free Kids Act of 2010. Final rule and interim final rule.

    PubMed

    2016-07-29

    This rule adopts as final, with some modifications, the National School Lunch Program and School Breakfast Program regulations set forth in the interim final rule published in the Federal Register on June 28, 2013. The requirements addressed in this rule conform to the provisions in the Healthy, Hunger-Free Kids Act of 2010 regarding nutrition standards for all foods sold in schools, other than food sold under the lunch and breakfast programs. Most provisions of this final rule were implemented on July 1, 2014, a full year subsequent to publication of the interim final rule. This was in compliance with section 208 of the Healthy, Hunger-Free Kids Act of 2010, which required that State and local educational agencies have at least one full school year from the date of publication of the interim final rule to implement the competitive food provisions. Based on comments received on the interim final rule and implementation experience, this final rule makes a few modifications to the nutrition standards for all foods sold in schools implemented on July 1, 2014. In addition, this final rule codifies specific policy guidance issued after publication of the interim rule. Finally, this rule retains the provision related to the standard for total fat as interim and requests further comment on this single standard. PMID:27476195

  7. PUNCTATE VASCULAR EXPRESSION1 Is a Novel Maize Gene Required for Leaf Pattern Formation That Functions Downstream of the Trans-Acting Small Interfering RNA Pathway1[C][W][OA

    PubMed Central

    Zhang, Xiaolan; Douglas, Ryan N.; Strable, Josh; Lee, Michelle; Buckner, Brent; Janick-Buckner, Diane; Schnable, Patrick S.; Timmermans, Marja C.P.; Scanlon, Michael J.

    2012-01-01

    The maize (Zea mays) gene RAGGED SEEDLING2-R (RGD2-R) encodes an ARGONAUTE7-like protein required for the biogenesis of trans-acting small interfering RNA, which regulates the accumulation of AUXIN RESPONSE FACTOR3A transcripts in shoots. Although dorsiventral polarity is established in the narrow and cylindrical leaves of rgd2-R mutant plants, swapping of adaxial/abaxial epidermal identity occurs and suggests a model wherein RGD2 is required to coordinate dorsiventral and mediolateral patterning in maize leaves. Laser microdissection-microarray analyses of the rgd2-R mutant shoot apical meristem identified a novel gene, PUNCTATE VASCULAR EXPRESSION1 (PVE1), that is down-regulated in rgd2-R mutant apices. Transcripts of PVE1 provide an early molecular marker for vascular morphogenesis. Reverse genetic analyses suggest that PVE1 functions during vascular development and in mediolateral and dorsiventral patterning of maize leaves. Molecular genetic analyses of PVE1 and of rgd2-R;pve1-M2 double mutants suggest a model wherein PVE1 functions downstream of RGD2 in a pathway that intersects and interacts with the trans-acting small interfering RNA pathway. PMID:22669891

  8. Identification in pituitary tissue of a peptide alpha-amidation activity that acts on glycine-extended peptides and requires molecular oxygen, copper, and ascorbic acid.

    PubMed

    Eipper, B A; Mains, R E; Glembotski, C C

    1983-08-01

    An enzymatic activity capable of producing an alpha-amidated peptide product from its glycine-extended precursor has been identified in secretory granules of rat anterior, intermediate, and neural pituitary and bovine intermediate pituitary. High levels of endogenous inhibitors of this alpha-amidation activity have also been found in tissue homogenates. The alpha-amidation activity is totally inhibited by addition of divalent metal ion chelators such as diethyldithiocarbamate, o-phenanthroline, and EDTA; alpha-amidation activity is restored to above control levels upon addition of copper. The alpha-amidation reaction requires the presence of molecular oxygen. Of the various cofactors tested, ascorbic acid was the most potent stimulator of alpha-amidation. The alpha-amidation activity has a neutral pH optimum and is primarily soluble following several cycles of freezing and thawing. Kinetic studies with the bovine intermediate pituitary granule-associated activity demonstrated a linear Lineweaver-Burk plot when D-Tyr-Val-Gly was the varied substrate; the apparent Km and Vmax varied with the concentration of ascorbic acid. The substrate specificity of the alpha-amidation activity appears to be quite broad; the conversion of D-Tyr-Val-Gly into D-Tyr-Val-NH2 is inhibited by the addition of a variety of glycine-extended peptides.

  9. [Patients' Rights Act].

    PubMed

    Haier, A J

    2016-09-01

    The new Patients' Rights Act does not reflect rights of patients as professional obligations of physicians for the first time. It adopted common longtime jurisdiction, but in some respects it is going beyond. This law clearly extended the documentation requirements of physicians, especially concerning the extent of documentation. In surgical fields the requirements for enlightening physicians were more strongly worded than in previous jurisdiction. In medical facilities it is now mandatory to establish an internal quality management system. PMID:27626814

  10. The USA PATRIOT Act.

    ERIC Educational Resources Information Center

    Minow, Mary; Coyle, Karen; Kaufman, Paula

    2002-01-01

    Explains the USA PATRIOT (Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism) Act, passed after the September 11 terrorist attacks, and its implications for libraries and patron records. Considers past dealings with the FBI; court orders; search warrants; wiretaps; and subpoenas. Includes:…

  11. 76 FR 16358 - Approval and Promulgation of Air Quality Implementation Plans; Connecticut, Maine, New Hampshire...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-23

    ... 0.12 parts per million (ppm) to 0.08 ppm (see 62 FR 38856). The Clean Air Act (CAA or Act) requires... submittals were deemed complete, effective April 28, 2008. (See 73 FR 16205; March 27, 2008.) III. What is... that are contrary to the CAA and existing EPA guidance (52 FR 45109, November 24, 1987), and the...

  12. 2009 Strategic Plan for Autism Spectrum Disorder Research. NIH Publication No. 09-7465

    ERIC Educational Resources Information Center

    Interagency Autism Coordinating Committee, 2009

    2009-01-01

    In response to the heightened societal concern over autism spectrum disorder (ASD), Congress passed the Combating Autism Act (CAA) of 2006 (P.L. 109-416). Through this Act, Congress intended to rapidly increase, accelerate the pace and improve coordination of scientific discovery in ASD research. The CAA requires the Interagency Autism…

  13. The CEO's second act.

    PubMed

    Nadler, David A

    2007-01-01

    When a CEO leaves because of performance problems, the company typically recruits someone thought to be better equipped to fix what the departing executive couldn't--or wouldn't. The board places its confidence in the new person because of the present dilemma's similarity to some previous challenge that he or she dealt with successfully. But familiar problems are inevitably succeeded by less familiar ones, for which the specially selected CEO is not quite so qualified. More often than not, the experiences, skills, and temperament that yielded triumph in Act I turn out to be unequal to Act II's difficulties. In fact, the approaches that worked so brilliantly in Act I may be the very opposite of what is needed in Act II. The CEO has four choices: refuse to change, in which case he or she will be replaced; realize that the next act requires new skills and learn them; downsize or circumscribe his or her role to compensate for deficiencies; or line up a successor who is qualified to fill a role to which the incumbent's skills and interests are no longer suited. Hewlett-Packard's Carly Fiorina exemplifies the first alternative; Merrill Lynch's Stanley O'Neal the second; Google's Sergey Brin and Larry Page the third; and Quest Diagnostics' Ken Freeman the fourth. All but the first option are reasonable responses to the challenges presented in the second acts of most CEOs' tenures. And all but the first require a power of observation, a propensity for introspection, and a strain of humility that are rare in the ranks of the very people who need those qualities most. There are four essential steps executives can take to discern that they have entered new territory and to respond accordingly: recognition that their leadership style and approach are no longer working; acceptance of others' advice on why performance is faltering; analysis and understanding of the nature of the Act II shift; and, finally, decision and action.

  14. The CEO's second act.

    PubMed

    Nadler, David A

    2007-01-01

    When a CEO leaves because of performance problems, the company typically recruits someone thought to be better equipped to fix what the departing executive couldn't--or wouldn't. The board places its confidence in the new person because of the present dilemma's similarity to some previous challenge that he or she dealt with successfully. But familiar problems are inevitably succeeded by less familiar ones, for which the specially selected CEO is not quite so qualified. More often than not, the experiences, skills, and temperament that yielded triumph in Act I turn out to be unequal to Act II's difficulties. In fact, the approaches that worked so brilliantly in Act I may be the very opposite of what is needed in Act II. The CEO has four choices: refuse to change, in which case he or she will be replaced; realize that the next act requires new skills and learn them; downsize or circumscribe his or her role to compensate for deficiencies; or line up a successor who is qualified to fill a role to which the incumbent's skills and interests are no longer suited. Hewlett-Packard's Carly Fiorina exemplifies the first alternative; Merrill Lynch's Stanley O'Neal the second; Google's Sergey Brin and Larry Page the third; and Quest Diagnostics' Ken Freeman the fourth. All but the first option are reasonable responses to the challenges presented in the second acts of most CEOs' tenures. And all but the first require a power of observation, a propensity for introspection, and a strain of humility that are rare in the ranks of the very people who need those qualities most. There are four essential steps executives can take to discern that they have entered new territory and to respond accordingly: recognition that their leadership style and approach are no longer working; acceptance of others' advice on why performance is faltering; analysis and understanding of the nature of the Act II shift; and, finally, decision and action. PMID:17286076

  15. Medicaid and Children's Health Insurance Programs; Mental Health Parity and Addiction Equity Act of 2008; the Application of Mental Health Parity Requirements to Coverage Offered by Medicaid Managed Care Organizations, the Children's Health Insurance Program (CHIP), and Alternative Benefit Plans. Final rule.

    PubMed

    2016-03-30

    This final rule will address the application of certain requirements set forth in the Public Health Service Act, as amended by the Paul Wellstone and Pete Domenici Mental Health Parity and Addiction Equity Act of 2008, to coverage offered by Medicaid managed care organizations, Medicaid Alternative Benefit Plans, and Children’s Health Insurance Programs.

  16. ABCG2 is up-regulated in Alzheimer's brain with cerebral amyloid angiopathy and may act as a gatekeeper at the blood-brain barrier for Aβ1-40 peptides

    PubMed Central

    Xiong, Huaqi; Callaghan, Debbie; Jones, Aimee; Bai, Jianying; Rasquinha, Ingrid; Smith, Catherine; Pei, Ke; Walker, Douglas; Lue, Lih-Fen; Stanimirovic, Danica; Zhang, Wandong

    2009-01-01

    Alzheimer's disease (AD) is characterized by accumulation and deposition of Aβ peptides in the brain. Aβ deposition in cerebrovessels occurs in many AD patients and results in cerebral amyloid angiopathy (AD/CAA). Since Aβ can be transported across blood-brain barrier (BBB), aberrant Aβ trafficking across BBB may contribute to Aβ accumulation in the brain and CAA development. Expression analyses of 273 BBB-related genes performed in this study showed that the drug transporter, ABCG2, was significantly up-regulated in the brains of AD/CAA compared to age-matched controls. Increased ABCG2 expression was confirmed by Q-PCR, Western blot and immunohistochemistry. Abcg2 was also increased in mouse AD models, Tg-SwDI and 3XTg. Aβ alone or in combination with hypoxia/ischemia failed to stimulate ABCG2 expression in BBB endothelial cells; however, conditioned media from Aβ-activated microglia strongly induced ABCG2 expression. ABCG2 protein in AD/CAA brains interacted and co-immunoprecipitated with Aβ. Overexpression of hABCG2 reduced drug uptake in cells; however, interaction of Aβ1-40 with ABCG2 impaired ABCG2-mediated drug efflux. The role of Abcg2 in Aβ transport at the BBB was investigated in Abcg2-null and wild-type mice after intravenous injection of Cy5.5-labeled Aβ1-40 or scrambled Aβ40-1. Optical imaging analyses of live animals and their brains showed that Abcg2-null mice accumulated significantly more Aβ in their brains than wt mice. The finding was confirmed by immunohistochemistry. These results suggest that ABCG2 may act as a gatekeeper at the BBB to prevent blood Aβ from entering into brain. ABCG2 up-regulation may serve as a biomarker of CAA vascular pathology in AD patients. PMID:19403814

  17. [The scope of expert competence for the evaluation of non-compliance with the requirements of the departmental normative legal acts in the course of forensic medical panel examinations concerning "medical practice" in the criminal legal procedures].

    PubMed

    Kovalev, A V; Pletianova, I V; Fetisov, V A

    2014-01-01

    This article is devoted to the analysis of the problem of expert competence for the evaluation of non-compliance with the requirements of the departmental normative legal acts in the course of forensic medical panel examinations concerning "medical practice" in the criminal legal procedures. The approaches to the solution of his problem are exemplified by forensic medical expertise of selected cases from obstetric and gynecological practice. It is demonstrated that investigations into non-compliance events arising in the work of medical facilities must include the analysis of the departmental normative legal acts that govern the organizational and diagnostic processes. These documents should be regarded as pertaining to an additional direct object and considered to be one of the constituent elements of.the offence to be identified during forensic medical expertise. Such documents are very specific in terms of their content and can not be properly interpreted by independent specialists possessing juristic knowledge alone. Therefore, the expert judgments concerning these issues must include well-reasoned arguments and solidly established evidence of normative legal character.

  18. Arts Require Timely Service (ARTS) Act

    THOMAS, 111th Congress

    Rep. Berman, Howard L. [D-CA-28

    2009-03-30

    04/27/2009 Referred to the Subcommittee on Immigration, Citizenship, Refugees, Border Security, and International Law. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  19. ACTS broadband aeronautical terminal

    NASA Technical Reports Server (NTRS)

    Agan, M. J.; Densmore, A. C.

    1995-01-01

    This paper discusses the design of, and experiments with, the ACTS Broadband Aeronautical Terminal. As part of the ongoing effort to investigate commercial applications of ACTS technologies, NASA's Jet Propulsion Laboratory and various industry/government partners are developing a broadband mobile terminal for aeronautical applications. The ACTS Broadband Aeronautical Terminal is designed to explore the use of K/Ka-band for high data rate aeronautical satellite communications. Currently available commercial aeronautical satellite communications systems are only capable of achieving data rates on the order of tens of kilobits per second. The broadband terminal used in conjunction with the ACTS mechanically steerable antenna, can achieve data rates of 384 kilobits per second, while use of an ACTS spot beam antenna with this terminal will allow up to T1 data rates (1.544 megabits per second). The aeronautical terminal will be utilized to test a variety of applications that require a high data rate communications link. The use of the K/Ka-band for wideband aeronautical communications has the advantages of spectrum availability and smaller antennas, while eliminating the one major drawback of this frequency band, rain attenuation, by flying above the clouds the majority of the time.

  20. National School Lunch Program and School Breakfast Program: nutrition standards for all foods sold in school as required by the Healthy, Hunger-Free Kids Act of 2010. Interim final rule.

    PubMed

    2013-06-28

    This interim final rule amends the National School Lunch Program and School Breakfast Program regulations to establish nutrition standards for all foods sold in schools, other than food sold under the lunch and breakfast programs. Amendments made by Section 208 of the Healthy, Hunger-Free Kids Act of 2010 (HHFKA) require the Secretary to establish nutrition standards for such foods, consistent with the most recent Dietary Guidelines for Americans, and directs the Secretary to consider authoritative scientific recommendations for nutrition standards; existing school nutrition standards, including voluntary standards for beverages and snack foods; current State and local standards; the practical application of the nutrition standards; and special exemptions for infrequent school-sponsored fundraisers (other than fundraising through vending machines, school stores, snack bars, à la carte sales and any other exclusions determined by the Secretary). In addition, this interim final rule requires schools participating in the National School Lunch Program and School Breakfast Program to make potable water available to children at no charge in the place where lunches are served during the meal service, consistent with amendments made by section 203 of the HHFKA, and in the cafeteria during breakfast meal service. This interim final rule is expected to improve the health and well-being of the Nation's children, increase consumption of healthful foods during the school day, and create an environment that reinforces the development of healthy eating habits.