Sample records for act mtca potential

  1. Timing module for MTCA MCH

    NASA Astrophysics Data System (ADS)

    Gumiński, M.; Kasprowicz, G.

    2016-09-01

    White Rabbit is an extension of Precise Time Protocol for synchronous Ethernet networks. Network created with dedicated WR switches enable synchronisation of WR capable devices with 1 ns precision. MicroTCA on the other hand is open standard defining cost efficient shelves capable of housing AMC modules used for data processing. Presented article give further introduction to WR and MTCA standard. The most important aspects of MTCA system are described, with focus on shelf controller and its functionality. Following part describes timing difficulties in MTCA systems and possible solutions. Main section describes extension module for MCH, capable of implementing White Rabbit node and distributing acquired timing to all modules connected to MTCA. Conclusions are given at the end of the article.

  2. The endoscopic endonasal approach is not superior to the microscopic transcranial approach for anterior skull base meningiomas-a meta-analysis.

    PubMed

    Muskens, Ivo S; Briceno, Vanessa; Ouwehand, Tom L; Castlen, Joseph P; Gormley, William B; Aglio, Linda S; Zamanipoor Najafabadi, Amir H; van Furth, Wouter R; Smith, Timothy R; Mekary, Rania A; Broekman, Marike L D

    2018-01-01

    In the past decade, the endonasal transsphenoidal approach (eTSA) has become an alternative to the microsurgical transcranial approach (mTCA) for tuberculum sellae meningiomas (TSMs) and olfactory groove meningiomas (OGMs). The aim of this meta-analysis was to evaluate which approach offered the best surgical outcomes. A systematic review of the literature from 2004 and meta-analysis were conducted in accordance with the PRISMA guidelines. Pooled incidence was calculated for gross total resection (GTR), visual improvement, cerebrospinal fluid (CSF) leak, intraoperative arterial injury, and mortality, comparing eTSA and mTCA, with p-interaction values. Of 1684 studies, 64 case series were included in the meta-analysis. Using the fixed-effects model, the GTR rate was significantly higher among mTCA patients for OGM (eTSA: 70.9% vs. mTCA: 88.5%, p-interaction < 0.01), but not significantly higher for TSM (eTSA: 83.0% vs. mTCA: 85.8%, p-interaction = 0.34). Despite considerable heterogeneity, visual improvement was higher for eTSA than mTCA for TSM (p-interaction < 0.01), but not for OGM (p-interaction = 0.33). CSF leak was significantly higher among eTSA patients for both OGM (eTSA: 25.1% vs. mTCA: 10.5%, p-interaction < 0.01) and TSM (eTSA: 19.3%, vs. mTCA: 5.81%, p-interaction < 0.01). Intraoperative arterial injury was higher among eTSA (4.89%) than mTCA patients (1.86%) for TSM (p-interaction = 0.03), but not for OGM resection (p-interaction = 0.10). Mortality was not significantly different between eTSA and mTCA patients for both TSM (p-interaction = 0.14) and OGM resection (p-interaction = 0.88). Random-effect models yielded similar results. In this meta-analysis, eTSA was not shown to be superior to mTCA for resection of both OGMs and TSMs.

  3. 75 FR 26275 - Notice of Lodging of Proposed Consent Decree

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-11

    ... Oceanic and Atmospheric Administration and the Department of the Interior; the State of Washington; the.... 9607(a); section 311 of the Clean Water Act (CWA), 33 U.S.C. 1321; section 1002(b) of the Oil Pollution Act (OPA), 33 U.S.C. 2702(b); and the Model Toxics Control Act (MTCA), RCW 70.105D. Under the proposed...

  4. Standardized Solution for Management Controller for MTCA.4

    NASA Astrophysics Data System (ADS)

    Makowski, D.; Fenner, M.; Ludwig, F.; Mavrič, U.; Mielczarek, A.; Napieralski, A.; Perek, P.; Schlarb, H.

    2015-06-01

    The Micro Telecommunications Computing Architecture (MTCA) standard is a modern platform that is gaining popularity in the area of High Energy Physics (HEP) experiments. The standard provides extensive management, monitoring and diagnostics functionalities. The hardware control and monitoring is based on the Intelligent Platform Management Interface (IPMI), that was initially developed for supervision of complex computers operation. The original IPMI specification was extended to support functions required by the MTCA specification. The Module Management Controller (MMC) is required on each Advanced Mezzanine Card (AMC) installed in MTCA chassis. The Rear Transition Modules (RTMs) have to be equipped with RTM Management Controllers (RMCs) which is required by the MTCA.4 subsidiary specification. The commercially available implementations of MMC and RMC are expensive and do not provide the complete functionality that is required by specific HEP applications. Therefore, many research centers and commercial companies work on their own implementation of AMC and RTM controllers. The available implementations suffer because of lack of common approach and interoperability problems. Since both Lodz University of Technology (TUL) and Deutsches Elektronen-Synchrotron (DESY) have long-term experience in developing ATCA and MTCA hardware, the authors decided to develop a unified solution of management controller fully compliant with AMC and MTCA.4 standards. The MMC v1.00 solution is dedicated for management of AMC and RTM modules. The MMC v1.00 is based on Atmel ATxmega MCUs and can be fully customized by the user or used as a drop-in-module without any modifications. The paper discusses the functionality of the MMC v1.00 solution. The implementation was verified with developed evaluation kits for AMC and RTM cards.

  5. The Methyltetrahydro-β-Carbolines in Maca (Lepidium meyenii)

    PubMed Central

    Gonzales-Castañeda, Cynthia

    2009-01-01

    Maca, a plant native to the Peruvian highlands, contains (1R,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (MTCA). The family of the tetrahydro-β-carbolines has been associated with both biologically helpful and harmful compounds. We present evidence that MTCA is a natural constituent of Maca, and on consumption no toxicity is found. This suggests that, when consumed as multi-component, MTCA may loose its adversity as drug action. PMID:18955346

  6. Permeability and toxicity characteristics of L-cysteine and 2-methyl-thiazolidine-4-carboxylic acid in Caco-2 cells.

    PubMed

    Kartal-Hodzic, Alma; Marvola, Tuuli; Schmitt, Mechthild; Harju, Kirsi; Peltoniemi, Marikki; Sivén, Mia

    2013-01-01

    Acetaldehyde is a known mutagenic substance and has been classified as a group-one carcinogen by the WHO. It is possible to bind acetaldehyde locally in the gastrointestinal (GI) tract with the semi-essential amino acid l-cysteine, which reacts covalently with acetaldehyde and forms compound 2-methyl-thiozolidine-4-carboxylic acid (MTCA). The Caco-2 cell line was used to determine the permeation of l-cysteine and MTCA, as well as the possible cell toxicity of both substances. Neither of the substances permeated through the Caco-2 cells at the concentrations used in this study, and only the highest concentration of MTCA affected the viability of the cells in the MTT (3-[4,5-dimethylthiazol-2yl]-2,5-diphenyltetrazolium bromide) test. These results showed that when l-cysteine is administered in formulations releasing it locally in the lower parts of GI tract, it is not absorbed but can react with acetaldehyde, and that neither l-cysteine nor MTCA is harmful to the cells when present locally in the upper parts of GI tract. This study also shows that MTCA is sensitive at a lower pH of 5.5. Since stable MTCA is desired in different parts of the GI tract, this observation raises concern over the influence of lower pH on l-cysteine-containing product ability to bind and eliminate carcinogenic acetaldehyde.

  7. Slow-release L-cysteine capsule prevents gastric mucosa exposure to carcinogenic acetaldehyde: results of a randomised single-blinded, cross-over study of Helicobacter-associated atrophic gastritis.

    PubMed

    Hellström, Per M; Hendolin, Panu; Kaihovaara, Pertti; Kronberg, Leif; Meierjohann, Axel; Millerhovf, Anders; Paloheimo, Lea; Sundelin, Heidi; Syrjänen, Kari; Webb, Dominic-Luc; Salaspuro, Mikko

    2017-02-01

    Helicobacter-induced atrophic gastritis with a hypochlorhydric milieu is a risk factor for gastric cancer. Microbes colonising acid-free stomach oxidise ethanol to acetaldehyde, a recognised group 1 carcinogen. To assess gastric production of acetaldehyde and its inert condensation product, non-toxic 2-methyl-1,3-thiazolidine-4-carboxylic acid (MTCA), after alcohol intake under treatment with slow-release L-cysteine or placebo. Seven patients with biopsy-confirmed atrophic gastritis, low serum pepsinogen and high gastrin-17 were studied in a cross-over single-blinded design. On separate days, patients randomly received 200 mg slow-release L-cysteine or placebo with intragastric instillation of 15% (0.3 g/kg) ethanol. After intake, gastric concentrations of ethanol, acetaldehyde, L-cysteine and MTCA were analysed. Administration of L-cysteine increased MTCA (p < .0004) and decreased gastric acetaldehyde concentrations by 68% (p < .0001). The peak L-cysteine level was 7552 ± 2687 μmol/L at 40 min and peak MTCA level 196 ± 98 μmol/L at 80 min after intake. Gastric L-cysteine and MTCA concentrations were maintained for 3 h. The AUC for MTCA was 11-fold higher than acetaldehyde, indicating gastric first-pass metabolism of ethanol. With placebo, acetaldehyde remained elevated also at low ethanol concentrations representing 'non-alcoholic' beverages and food items. After gastric ethanol instillation, slow-release L-cysteine eliminates acetaldehyde to form inactive MTCA, which remains in gastric juice for up to 3 h. High acetaldehyde levels indicate a marked gastric first-pass metabolism of ethanol resulting in gastric accumulation of carcinogenic acetaldehyde. Local exposure of the gastric mucosa to acetaldehyde can be mitigated by slow-release L-cysteine capsules.

  8. IEEE 1588 Time Synchronization Board in MTCA.4 Form Factor

    NASA Astrophysics Data System (ADS)

    Jabłoński, G.; Makowski, D.; Mielczarek, A.; Orlikowski, M.; Perek, P.; Napieralski, A.; Makijarvi, P.; Simrock, S.

    2015-06-01

    Distributed data acquisition and control systems in large-scale scientific experiments, like e.g. ITER, require time synchronization with nanosecond precision. A protocol commonly used for that purpose is the Precise Timing Protocol (PTP), also known as IEEE 1588 standard. It uses the standard Ethernet signalling and protocols and allows obtaining timing accuracy of the order of tens of nanoseconds. The MTCA.4 is gradually becoming the platform of choice for building such systems. Currently there is no commercially available implementation of the PTP receiver on that platform. In this paper, we present a module in the MTCA.4 form factor supporting this standard. The module may be used as a timing receiver providing reference clocks in an MTCA.4 chassis, generating a Pulse Per Second (PPS) signal and allowing generation of triggers and timestamping of events on 8 configurable backplane lines and two front panel connectors. The module is based on the Xilinx Spartan 6 FPGA and thermally stabilized Voltage Controlled Oscillator controlled by the digital-to-analog converter. The board supports standalone operation, without the support from the host operating system, as the entire control algorithm is run on a Microblaze CPU implemented in the FPGA. The software support for the card includes the low-level API in the form of Linux driver, user-mode library, high-level API: ITER Nominal Device Support and EPICS IOC. The device has been tested in the ITER timing distribution network (TCN) with three cascaded PTP-enabled Hirschmann switches and a GPS reference clock source. An RMS synchronization accuracy, measured by direct comparison of the PPS signals, better than 20 ns has been obtained.

  9. Facile preparation of Ni nanowire embedded nitrogen and sulfur dual-doped carbon nanofibers and its superior catalytic activity toward urea oxidation.

    PubMed

    Liu, Dong; Li, Wenjia; Li, Libo; Ling, Hao; You, Tianyan

    2018-06-08

    A novel hairy-shaped Ni nanowire embedded nitrogen and sulfur dual-doped carbon nanofibers (Ni/N,S-CNFs) with superior electrocatalytic properties for urea oxidation reaction (UOR) was reported. The Ni/N,S-CNFs was prepared by electrospinning and carbonization process, using melamine-trithiocyanuric acid (MTCA) aggregates as both the N and S element sources. Noteworthy, MTCA also favored the formation of Ni nanowire via vapor liquid-solid mechanism, while Ni nanoparticles loaded CNFs (Ni/CNFs) was obtained without MTCA. For UOR tests, a high peak current intensity of 37.0 mA mg -1 was obtained on Ni/N,S-CNFs at 0.42 V (vs. SCE), 2-times higher of that on Ni/CNFs. Besides, the catalytic stability of Ni/N,S-CNFs was also improved. The enhanced catalytic properties of Ni/N,S-CNFs for UOR were ascribed to its unique Ni nanowires structure as well as the N, S dual-doping. Our work reveals that the property improvement of metal-based catalysts could be achieved by the heteroatom doping to fine the metal nanostructure. Copyright © 2018. Published by Elsevier Inc.

  10. A versatile small form factor twisted-pair TFC FMC for MTCA AMCs

    NASA Astrophysics Data System (ADS)

    Meder, L.; Lebedev, J.; Becker, J.

    2017-03-01

    In continuous readout systems of particle physics experiments, the provision of a common clock and time reference and the distribution of critical low latency messages to the processing and fronted layers of the readout are crucial tasks. In the context of the Compressed Baryonic Matter (CBM) experiment, a versatile small form factor Timing and Fast-Control (TFC) interfacing FPGA Mezzanine Card (FMC) was developed, offering bidirectional twisted-pair (TP) links for the communication between TFC nodes. Also a versatile clocking including voltage controlled oscillators and a connection to the telecommunication clock lines of mTCA crates are available. Being designed for both TFC Master and Slaves, the card allows rapid system developments without additional Slave hardware circuits. Measurements show that it is possible to transmit over cable lengths of 25 m at a rate of 240 Mbit/s for all data channels simultaneously. A TFC Master-Slave system using two of these cards can be synchronized with a precision of ±10 ps to an user-defined phase setpoint.

  11. Smart BIT/TSMD Integration

    DTIC Science & Technology

    1991-12-01

    user using the ’: knn ’ option in the do-scenario command line). An instance of the K-Nearest Neighbor object is first created and initialized before...Navigation Computer HF High Frequency ILS Instrument Landing System KNN K - Nearest Neighbor LRU Line Replaceable Unit MC Mission Computer MTCA...approaches have been investigated here, K-nearest Neighbors ( KNN ) and neural networks (NN). Both approaches require that previously classified examples of

  12. A Timing Synchronizer System for Beam Test Setups Requiring Galvanic Isolation

    NASA Astrophysics Data System (ADS)

    Meder, Lukas Dominik; Emschermann, David; Frühauf, Jochen; Müller, Walter F. J.; Becker, Jürgen

    2017-07-01

    In beam test setups detector elements together with a readout composed of frontend electronics (FEE) and usually a layer of field-programmable gate arrays (FPGAs) are being analyzed. The FEE is in this scenario often directly connected to both the detector and the FPGA layer what in many cases requires sharing the ground potentials of these layers. This setup can become problematic if parts of the detector need to be operated at different high-voltage potentials, since all of the FPGA boards need to receive a common clock and timing reference for getting the readout synchronized. Thus, for the context of the compressed baryonic matter experiment a versatile timing synchronizer (TS) system was designed providing galvanically isolated timing distribution links over twisted-pair cables. As an electrical interface the so-called timing data processing board FPGA mezzanine card was created for being mounted onto FPGA-based advanced mezzanine cards for mTCA.4 crates. The FPGA logic of the TS system connects to this card and can be monitored and controlled through IPBus slow-control links. Evaluations show that the system is capable of stably synchronizing the FPGA boards of a beam test setup being integrated into a hierarchical TS network.

  13. Rapid-X - An FPGA Development Toolset Using a Custom Simulink Library for MTCA.4 Modules

    NASA Astrophysics Data System (ADS)

    Prędki, Paweł; Heuer, Michael; Butkowski, Łukasz; Przygoda, Konrad; Schlarb, Holger; Napieralski, Andrzej

    2015-06-01

    The recent introduction of advanced hardware architectures such as the Micro Telecommunications Computing Architecture (MTCA) caused a change in the approach to implementation of control schemes in many fields. The development has been moving away from traditional programming languages ( C/C++), to hardware description languages (VHDL, Verilog), which are used in FPGA development. With MATLAB/Simulink it is possible to describe complex systems with block diagrams and simulate their behavior. Those diagrams are then used by the HDL experts to implement exactly the required functionality in hardware. Both the porting of existing applications and adaptation of new ones require a lot of development time from them. To solve this, Xilinx System Generator, a toolbox for MATLAB/Simulink, allows rapid prototyping of those block diagrams using hardware modelling. It is still up to the firmware developer to merge this structure with the hardware-dependent HDL project. This prevents the application engineer from quickly verifying the proposed schemes in real hardware. The framework described in this article overcomes these challenges, offering a hardware-independent library of components that can be used in Simulink/System Generator models. The components are subsequently translated into VHDL entities and integrated with a pre-prepared VHDL project template. Furthermore, the entire implementation process is run in the background, giving the user an almost one-click path from control scheme modelling and simulation to bit-file generation. This approach allows the application engineers to quickly develop new schemes and test them in real hardware environment. The applications may range from simple data logging or signal generation ones to very advanced controllers. Taking advantage of the Simulink simulation capabilities and user-friendly hardware implementation routines, the framework significantly decreases the development time of FPGA-based applications.

  14. The Common Data Acquisition Platform in the Helmholtz Association

    NASA Astrophysics Data System (ADS)

    Kaever, P.; Balzer, M.; Kopmann, A.; Zimmer, M.; Rongen, H.

    2017-04-01

    Various centres of the German Helmholtz Association (HGF) started in 2012 to develop a modular data acquisition (DAQ) platform, covering the entire range from detector readout to data transfer into parallel computing environments. This platform integrates generic hardware components like the multi-purpose HGF-Advanced Mezzanine Card or a smart scientific camera framework, adding user value with Linux drivers and board support packages. Technically the scope comprises the DAQ-chain from FPGA-modules to computing servers, notably frontend-electronics-interfaces, microcontrollers and GPUs with their software plus high-performance data transmission links. The core idea is a generic and component-based approach, enabling the implementation of specific experiment requirements with low effort. This so called DTS-platform will support standards like MTCA.4 in hard- and software to ensure compatibility with commercial components. Its capability to deploy on other crate standards or FPGA-boards with PCI express or Ethernet interfaces remains an essential feature. Competences of the participating centres are coordinated in order to provide a solid technological basis for both research topics in the Helmholtz Programme ``Matter and Technology'': ``Detector Technology and Systems'' and ``Accelerator Research and Development''. The DTS-platform aims at reducing costs and development time and will ensure access to latest technologies for the collaboration. Due to its flexible approach, it has the potential to be applied in other scientific programs.

  15. Depth of the biologically active zone in upland habitats at the Hanford Site, Washington: Implications for remediation and ecological risk management.

    PubMed

    Sample, Bradley E; Lowe, John; Seeley, Paul; Markin, Melanie; McCarthy, Chris; Hansen, Jim; Aly, Alaa H

    2015-01-01

    Soil invertebrates, mammals, and plants penetrate and exploit the surface soil layer (i.e., the biologically active zone) to varying depths. As the US Department of Energy remediates radioactive and hazardous wastes in soil at the Hanford Site, a site-specific definition of the biologically active zone is needed to identify the depth to which remedial actions should be taken to protect the environment and avoid excessive cleanup expenditures. This definition may then be considered in developing a point of compliance for remediation in accordance with existing regulations. Under the State of Washington Model Toxic Control Act (MTCA), the standard point of compliance for soil cleanup levels with unrestricted land use is 457 cm (15 ft) below ground surface. When institutional controls are required to control excavations to protect people, MTCA allows a conditional point of compliance to protect biological resources based on the depth of the biologically active zone. This study was undertaken to identify and bound the biologically active zone based on ecological resources present at the Hanford Site. Primary data were identified describing the depths to which ants, mammals, and plants may exploit the surface soil column at the Hanford Site and other comparable locations. The maximum depth observed for harvester ants (Pogonomyrmex spp.) was 270 cm (8.9 ft), with only trivial excavation below 244 cm (8 ft). Badgers (Taxidea taxus) are the deepest burrowing mammal at the Hanford Site, with maximum burrow depths of 230 cm (7.6 ft); all other mammals did not burrow below 122 cm (4 ft). Shrubs are the deepest rooting plants with rooting depths to 300 cm (9.8 ft) for antelope bitterbrush (Purshia tridentata). The 2 most abundant shrub species did not have roots deeper than 250 cm (8.2 ft). The deepest rooted forb had a maximum root depth of 240 cm (7.9 ft). All other forbs and grasses had rooting depths of 200 cm (6.6 ft) or less. These data indicate that the biologically active soil zone in the Hanford Central Plateau does not exceed 300 cm (9.8 ft), the maximum rooting depth for the deepest rooting plant. The maximum depth at which most other plant and animal species occur is substantially shallower. Spatial distribution and density of burrows and roots over depths were also evaluated. Although maximum excavation by harvester ants is 270 cm (8.9 ft), trivial volume of soil is excavated below 150 cm (∼5 ft). Maximum rooting depths for all grasses, forbs, and the most abundant and deepest rooting shrubs are 300 cm (9.8 ft) or less. Most root biomass (>50-80%) is concentrated in the top 100 cm (3.3 ft), whereas at the maximum depth (9.8 ft), only trace root biomass is present. Available data suggest a limited likelihood for significant transport of contaminants to the surface by plants at or below 244 cm (8 ft), and suggest that virtually all plants or animal species occurring on the Central Plateau have a negligible likelihood for transporting soil contaminants to the surface from depths at or below 305 cm (10 ft). © 2014 SETAC.

  16. Docking based design of diastereoisomeric MTCA as GPIIb/IIIa receptor inhibitor.

    PubMed

    Wang, Xiaozhen; Wang, Yuji; Wu, Jianhui; Gui, Lin; Zhang, Xiaoyi; Zheng, Meiqing; Wang, Yaonan; Zhao, Shurui; Li, Ze; Zhao, Ming; Peng, Shiqi

    2017-12-01

    In GPIIb/IIIa mediated arterial thrombosis platelet activation plays a central role. To discover platelet activation inhibitor the pharmacophores of GPIIb/IIIa receptor inhibitors and anti-thrombotic agents were analyzed. This led to the design of (1R,3S)- and (1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acids as GPIIb/IIIa inhibitors. Comparing to (1S,3S)-isomer (1R,3S)-isomer had lower cdocker interaction energy. AFM image showed that the minimal effective concentration of (1S,3S)-isomer and (1R,3S)-isomer inhibiting platelet activation were 10 -5  M and 10 -6  M, respectively. In vivo 1 μmol/kg of oral (1S,3S)-isomer effectively inhibited the rats to form arterial thrombus and down regulated GPIIb/IIIa expression, but the activities were significantly lower than those of 1 μmol/kg of oral (1R,3S)-isomer. Both (1S,3S)-isomer and (1R,3S)-isomer can be safely used for structural modifications, but (1R,3S)-isomer should be superior to (1S,3S)-isomer. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. Femoral Component Varus Malposition is Associated with Tibial Aseptic Loosening After TKA.

    PubMed

    Lee, Bum-Sik; Cho, Hyun-Ik; Bin, Seong-Il; Kim, Jong-Min; Jo, Byeong-Kyu

    2018-02-01

    The notion that neutral alignment is mandatory to assure long-term durability after TKA has been based mostly on short-film studies. However, this is challenged by recent long-film studies. We conducted this long-film study to know (1) whether the risk of aseptic revision for nontraumatic reasons was greater among knees with greater than 3° varus or valgus (defined as "outliers") than those that were aligned within 3° of neutral on long-standing mechanical axis (hip to knee) radiographs; and (2) what the failure mechanisms were and whether the malalignment was femoral or tibial in origin, or both, among those in the outlier group. Between November 1998 and January 2009 we performed 1299 cemented, posterior cruciate ligament-substituting TKAs in 867 patients for primary osteoarthritis. We had inadequate long-standing radiographs to analyze postoperative alignment for 124 of those knees, and an additional 24 were excluded for prespecified reasons. Consequently, 1151 knees were enrolled in our study. Of these, 982 (85%) in 661 patients (620 women and 41 men) who had followup greater than 24 months were analyzed. The knees were divided according to whether the postoperative mechanical axis was neutral (0° ± 3°), varus (> 3°), or valgus (< -3°) alignment on long-standing radiographs. The survivorships free from aseptic revision for nontraumatic reasons were compared among groups. The mechanical femoral and the tibial component alignment (MFCA and MTCA, respectively) were investigated to know the origin of overall mechanical malalignment of the outlier knees. The mean duration of followup was 8 ± 4 years (range, 2-17 years). Thirty-five knees (4%) showed aseptic loosening at 7 ± 4 years (range, 0.1-14 years) and five (1%) showed polyethylene wear at 12 ± 1 years (range, 10-13 years). Tibial loosening (73%) was the most common reason for aseptic revision followed by femoral loosening (30%). Of this cohort, 687 (70%), 250 (25%), and 45 (5%) knees had overall mechanical neutral, varus, and valgus alignment, respectively. Factors associated with the risk of aseptic revision were identified by Cox regression. The varus outliers (but not the valgus outliers) failed more often than the neutral knees (10% [25 of 250] versus 2% [13 of 687]; odds ratio [OR], 5.8, 95% CI, 2.9-11.5; p < 0.001). Ten-year survivorship free from aseptic revision was lower among varus outliers than among knees with neutral alignment (87% [95% CI, 80%-93%] versus 98% [95% CI, 97%-99%]; p = 0.001). Femoral component varus malpositioning was the main origin of the varus outliers (MFCA = 4.2° ± 2.0°; MTCA = 0.9° ± 1.7°) and was a risk factor for aseptic revision compared with neutral femoral positioning (OR, 14.0; 95% CI, 1.9-105.6; p < 0.001). This long-film study corresponds to previous short-film studies for the notion that varus malalignment is associated with inferior long-term implant survivorship. Although aseptic loosening occurred most commonly on the tibial side, the primary origin of the overall varus malalignment was femoral component varus malpositioning. Aiming for neutral alignment in TKA still seems to be a reasonable strategy in clinical practice. Level III, therapeutic study.

  18. A Model-Based Fast Protection System for High-Power RF Tube Amplifiers Used at the European XFEL Accelerator

    NASA Astrophysics Data System (ADS)

    Butkowski, Łukasz; Vogel, Vladimir; Schlarb, Holger; Szabatin, Jerzy

    2017-06-01

    The driving engine of the superconducting accelerator of the European X-ray free electron laser (XFEL) is a set of 27 radio frequency (RF) stations. Each of the underground RF stations consists of a multibeam horizontal klystron that can provide up to 10 MW of power at 1.3 GHz. Klystrons are sensitive devices with a limited lifetime and a high mean time between failures. In real operation, the lifetime of the tube can be significantly reduced because of failures. The special fast protection klystron lifetime management (KLM) system has been developed to minimize the influence of service conditions on the lifetime of klystrons. The main task of this system is to detect all events which can destroy the tube as quickly as possible, and switch off the driving RF signal or the high voltage. Detection of events is based on a comparison of the value of the real signal obtained at the system output with the value estimated on the basis of a high-power RF amplifier model and input signals. The KLM system has been realized in field-programmable gate array (FPGA) and implemented in XFEL. Implementation is based on the standard low-level RF micro telecommunications computing architecture (MTCA.4 or xTCA). The main part of the paper focuses on an estimation of the klystron model and the implementation of KLM in FPGA. The results of the performance of the KLM system will also be presented.

  19. Potential communicative acts in children with autism spectrum disorders.

    PubMed

    Braddock, Barbara A; Pickett, Colleen; Ezzelgot, Jamie; Sheth, Shivani; Korte-Stroff, Emily; Loncke, Filip; Bock, Lynn

    2015-01-01

    To describe potential communicative acts in a sample of 17 children with autism spectrum disorders who produced few to no intelligible words (mean age = 32.82 months). Parents reported on children's potential communicative acts for 10 different communicative functions. A potential communicative act was defined as any behavior produced by an individual that may be interpreted by others to serve a communicative purpose. Significant associations were found between higher number of gesture types and increased scores on language comprehension, language expression, and non-verbal thinking measures. Relative to other types of potential communicative acts, parents reported that children used higher proportions of body movement. Number of body movement types was not related to child ability, while number of gesture types was related to receptive and expressive language. Findings underscore the link between language and gesture, and offer support for an ecological systems perspective of language learning.

  20. Photonics applications and web engineering: WILGA Winter 2016

    NASA Astrophysics Data System (ADS)

    Romaniuk, Ryszard S.

    2016-09-01

    Since twenty years, young researchers form the Institute of Electronic Systems, Warsaw University of Technology, organize two times a year, under only a marginal supervision of the senior faculty members, under the patronage of WEiTI PW, KEiT PAN, SPIE, IEEE, PKOpto SEP and PSF, the WILGA Symposium on advanced, integrated functional electronic, photonic and mechatronic systems [1-5]. All aspects are considered like: research and development, theory and design, technology - material and construction, software and hardware, commissioning and tests, as well as pilot and practical applications. The applications concern mostly, which turned after several years to be a proud specialization of the WILGA Symposium, Internet engineering, high energy physics experiments, new power industry including fusion, nuclear industry, space and satellite technologies, telecommunications, smart municipal environment, as well as biology and medicine [6-8]. XXXVIIth WILGA Symposium was held on 29-31 January 2016 and gathered a few tens of young researchers active in the mentioned research areas. There were presented a few tens of technical papers which will be published in Proc.SPIE together with the accepted articles from the Summer Edition of the WILGA Symposium scheduled for 29.05-06.06.2016. This article is a digest of chosen presentations from WILGA Symposium 2016 Winter Edition. The survey is narrowed to a few chosen and main topical tracks, like electronics and photonics design using industrial standards like ATCA/MTCA, also particular designs of functional systems using this series of industrial standards. The paper, summarizing traditionally since many years the accomplished WILGA Symposium organized by young researchers from Warsaw University of Technology, is also the following part of a cycle of papers concerning their participation in design of new generations of electronic systems used in discovery experiments in Poland and in leading research laboratories of the world.

  1. Adoptive T cell therapy: An overview of obstacles and opportunities.

    PubMed

    Baruch, Erez Nissim; Berg, Amy Lauren; Besser, Michal Judith; Schachter, Jacob; Markel, Gal

    2017-06-01

    The therapeutic potential of adoptive cell therapy (ACT) in cancer patients was first acknowledged 3 decades ago, but it was an esoteric approach at the time. In recent years, technological advancements have transformed ACT into a viable therapeutic option that can be curative in some patients. In fact, current ACT response rates are 80% to 90% for hematological malignancies and 30% for metastatic melanoma refractory to multiple lines of therapy. Although these results are encouraging, there is still much to be done to fulfill ACT's potential, specifically with regard to improving clinical efficacy, expanding clinical indications, reducing toxicity, and increasing production and cost-effectiveness. This review addresses the current major obstacles to ACT and presents potential solutions. Cancer 2017;123:2154-62. © 2017 American Cancer Society. © 2017 American Cancer Society.

  2. 77 FR 44562 - Public Meeting: Potential Regulatory Implications of the Reduction of Lead in Drinking Water Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-30

    ... Regulatory Implications of the Reduction of Lead in Drinking Water Act of 2011 AGENCY: Environmental... public meeting on August 16, 2012, to discuss and solicit input from States, manufacturers, drinking... Drinking Water Act of 2011 (``the Act''). The Act was signed on January 4, 2011, and will be effective on...

  3. 77 FR 12297 - Petition To Demonstrate Paperwork Reduction Act Compliance of the Endocrine Disruptor Screening...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-29

    ... Paperwork Reduction Act Compliance of the Endocrine Disruptor Screening Program; Notice of Availability... chemicals to receive orders under the Endocrine Disruptor Screening Program by demonstrating the information... potential endocrine effects. Potentially affected entities identified by the North American Industrial...

  4. Extended-release hydrocodone – gift or curse?

    PubMed Central

    Krashin, Daniel; Murinova, Natalia; Trescot, Andrea M

    2013-01-01

    Hydrocodone is a semisynthetic opioid, which has been used for decades as a short-acting analgesic combined with acetaminophen (or less commonly ibuprofen). Several long-acting, non-acetaminophen-containing hydrocodone formulations are undergoing trials in the US under the auspices of the US Food and Drug Administration, and may be available shortly. This article reviews some of the advantages (including drug familiarity and lack of acetaminophen toxicity) and potential disadvantages (including altered use patterns and high morphine equivalent dosing) of such a medication formulation. We also discuss the abuse potential of long-acting versus short-acting opioids in general and hydrocodone specifically, as well as the metabolism of hydrocodone. PMID:23358452

  5. Acceptance and Commitment Therapy (ACT) as a Career Counselling Strategy

    ERIC Educational Resources Information Center

    Hoare, P. Nancey; McIlveen, Peter; Hamilton, Nadine

    2012-01-01

    Acceptance and commitment therapy (ACT) has potential to contribute to career counselling. In this paper, the theoretical tenets of ACT and a selection of its counselling techniques are overviewed along with a descriptive case vignette. There is limited empirical research into ACT's application in career counselling. Accordingly, a research agenda…

  6. Geothermal Induced Seismicity National Environmental Policy Act Review

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Levine, Aaron L; Cook, Jeffrey J; Beckers, Koenraad J

    This presentation reviews four National Environmental Policy Act of 1969 (NEPA) documents to understand how Federal agencies, including the U.S. Bureau of Land Management and Department of Energy, review and analyze the potential impacts to the human environment when funding or approving permits for enhanced geothermal system with the potential for induced seismicity.

  7. Rigid Response in an Age of Accountability: The Potential of Leadership and Trust

    ERIC Educational Resources Information Center

    Daly, Alan J.

    2009-01-01

    Purpose: The No Child Left Behind Act laudably brings social justice and equity issues to the forefront; however, the act's threat- and sanction-driven methods are not only increasing stress levels but potentially causing a rigid response, especially in the growing population of schools labeled "program improvement" (PI). Specifically,…

  8. The 2008 Amendments to the Americans with Disabilities Act: Implications for Student Affairs Practitioners

    ERIC Educational Resources Information Center

    Burke, Lisa A.; Friedl, John; Rigler, Michelle

    2010-01-01

    The Americans with Disabilities Act Amendments Act (ADAAA), which became effective at the beginning of 2009, is poised to have potentially wide-reaching implications for higher education. The article reviews the recent amendments to the original Americans with Disabilities Act (ADA) (1990), summarizes the relevant Supreme Court cases that have…

  9. Talkin' 'Bout Meta-Generation: ACT UP History and Queer Futurity

    ERIC Educational Resources Information Center

    Emmer, Pascal

    2012-01-01

    The transmission of ACT UP's movement histories is indispensable to the potential for what Jose Esteban Munoz calls "queer futurity," or "a temporal arrangement in which the past is a field of possibility in which subjects can act in the present in the service of a new futurity." Roger Hallas argues that ACT UP's material and visual archive alone…

  10. 78 FR 20291 - Fisheries of the United States; Billfish Conservation Act of 2012 Implementing Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-04

    .... 121227743-3275-01] RIN 0648-BC86 Fisheries of the United States; Billfish Conservation Act of 2012... request public comment on potential issues related to the implementation of the Billfish Conservation Act... Conservation Act of 2012 (BCA), Public Law 112-183, 16 U.S.C. 1827a, was signed into law on October 5, 2012...

  11. Would introverts be better off if they acted more like extraverts? Exploring emotional and cognitive consequences of counterdispositional behavior.

    PubMed

    Zelenski, John M; Santoro, Maya S; Whelan, Deanna C

    2012-04-01

    People enjoy acting extraverted, and this seems to apply equally across the dispositional introversion-extraversion dimension (Fleeson, Malanos, & Achille, 2002). It follows that dispositional introverts might improve their happiness by acting more extraverted, yet little research has examined potential costs of this strategy. In two studies, we assessed dispositions, randomly assigned participants to act introverted or extraverted, and examined costs-both emotional (concurrent negative affect) and cognitive (Stroop performance). Results replicated and extended past findings suggesting that acting extraverted produces hedonic benefits regardless of disposition. Positive affect increased and negative affect did not, even for participants acting out of character. In contrast, we found evidence that acting counterdispositionally could produce poor Stroop performance, but this effect was limited to dispositional extraverts who were assigned to act introverted. We suggest that the positive affect produced by introverts' extraverted behavior may buffer the potentially depleting effects of counterdispositional behavior, and we consider alternative explanations. We conclude that dispositional introverts may indeed benefit from acting extraverted more often and caution that dispositional extraverts may want to adopt introverted behavior strategically, as it could induce cognitive costs or self-regulatory depletion more generally. (PsycINFO Database Record (c) 2012 APA, all rights reserved).

  12. Reported communication ability of persons with trisomy 18 and trisomy 13.

    PubMed

    Liang, Cheryl A; Braddock, Barbara A; Heithaus, Jennifer L; Christensen, Katherine M; Braddock, Stephen R; Carey, John C

    2015-01-01

    The aim of this study was to describe the communication ability of individuals with trisomy 18 and trisomy 13 syndromes. Parents reported on children's potential communication acts, words, spontaneous gesture, and augmentative and alternative communication (AAC) using a parent report inventory (n = 32; age range 3-35 years). Potential communicative acts are defined as behaviors produced by an individual that may be interpreted by others to serve communicative functions. Potential communicative acts categorized as body movement displayed the highest median rank for reported occurrence followed by vocalization and facial expression. Although symbolic forms were ranked lower, more than half of the parents (66%) reported that their children produced at least one word, gesture or AAC form. Challenging behaviors or stereotypic movement displayed lowest median ranks. Results are discussed in terms of communication potential and the need to address AAC in trisomy 18 and 13.

  13. Tobacco packaging and labeling policies under the U.S. Tobacco Control Act: research needs and priorities.

    PubMed

    Hammond, David

    2012-01-01

    The Family Smoking Prevention and Tobacco Control Act (the "Act"), enacted in June 2009, gave the U.S. Food and Drug Administration authority to regulate tobacco products. The current paper reviews the provisions for packaging and labeling, including the existing evidence and research priorities. Narrative review using electronic literature search of published and unpublished sources in 3 primary areas: health warnings, constituent labeling, and prohibitions on the promotional elements of packaging. The Act requires 9 pictorial health warnings covering half of cigarette packages and 4 text warnings covering 30% of smokeless tobacco packages. The Act also prohibits potentially misleading information on packaging, including the terms "light" and "mild," and provides a mandate to require disclosure of chemical constituents on packages. Many of the specific regulatory provisions are based on the extent to which they promote "greater public understanding of the risks of tobacco." As a result, research on consumer perceptions has the potential to shape the design and renewal of health warnings and to determine what, if any, information on product constituents should appear on packages. Research on consumer perceptions of existing and novel tobacco products will also be critical to help identify potentially misleading information that should be restricted under the Act. Packaging and labeling regulations required under the Act will bring the United States in line with international standards. There is an immediate need for research to evaluate these measures to guide future regulatory action.

  14. An Event-Related Potential Study of Adolescents' and Young Adults' Judgments of Moral and Social Conventional Violations

    ERIC Educational Resources Information Center

    Lahat, Ayelet; Helwig, Charles C.; Zelazo, Philip David

    2013-01-01

    The neurocognitive development of moral and conventional judgments was examined. Event-related potentials were recorded while 24 adolescents (13 years) and 30 young adults (20 years) read scenarios with 1 of 3 endings: moral violations, conventional violations, or neutral acts. Participants judged whether the act was acceptable or unacceptable…

  15. 75 FR 39273 - Energy Independence and Security Act (Pub. L. 110-140)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-08

    ... DEPARTMENT OF THE INTERIOR U.S. Geological Survey Energy Independence and Security Act (Pub. L... Resource Assessment Methodology. SUMMARY: In 2007, the Energy Independence and Security Act (Pub. L. 110... provide important information to evaluate the potential for CO 2 storage as a mitigation option for global...

  16. A Motive of Rhetorics: Invention and Speech Acts.

    ERIC Educational Resources Information Center

    Schneider, Michael J.

    While rhetorical theory has long been concerned with the epistemological foundations of rhetorical abilities, the full potential of the structuralist perspective is far from realized. The study of speech acts and inventive processes discloses the underlying logic of linguistic performance. A speech act is conceptualized in terms of the…

  17. Developmental exposure to perchlorate alters synaptic transmission in hippocampus of the adult rat.

    EPA Science Inventory

    The Food Quality Protection Act and Safe Drinking Water Act mandate the EPA to identify potential health risks associated with chemicals that act on the endocrine system. Perchlorate, a contaminant found in food and water supplies throughout the USA, blocks iodine uptake into the...

  18. Post-transcriptional regulation of α-1-antichymotrypsin by microRNA-137 in chronic heart failure and mechanical support.

    PubMed

    Lok, Sjoukje I; van Mil, Alain; Bovenschen, Niels; van der Weide, Petra; van Kuik, Joyce; van Wichen, Dick; Peeters, Ton; Siera, Erica; Winkens, Bjorn; Sluijter, Joost P G; Doevendans, Pieter A; da Costa Martins, Paula A; de Jonge, Nicolaas; de Weger, Roel A

    2013-07-01

    Better understanding of the molecular mechanisms of remodeling has become a major objective of heart failure (HF) research to stop or reverse its progression. Left ventricular assist devices (LVADs) are being used in patients with HF, leading to partial reverse remodeling. In the present study, proteomics identified significant changes in α-1-antichymotrypsin (ACT) levels during LVAD support. Moreover, the potential role of ACT in reverse remodeling was studied in detail. Expression of ACT mRNA (quantitative-polymerase chain reaction) decreased significantly in post-LVAD myocardial tissue compared with pre-LVAD tissue (n=15; P<0.01). Immunohistochemistry revealed that ACT expression and localization changed during LVAD support. Circulating ACT levels were elevated in HF patients (n=18) as compared with healthy controls (n=6; P=0.001) and normalized by 6 months of LVAD support. Because increasing evidence implicates that microRNAs (miRs) are involved in myocardial disease processes, we also investigated whether ACT is post-transcriptionally regulated by miRs. Bioinformatics analysis pointed miR-137 as a potential regulator of ACT. The miR-137 expression is inversely correlated with ACT mRNA in myocardial tissue. Luciferase activity assays confirmed ACT as a direct target for miR-137, and in situ hybridization indicated that ACT and miR-137 were mainly localized in cardiomyocytes and stromal cells. High ACT plasma levels in HF normalized during LVAD support, which coincides with decreased ACT mRNA in heart tissue, whereas miR-137 levels increased. MiR-137 directly targeted ACT, thereby indicating that ACT and miR-137 play a role in the pathophysiology of HF and reverse remodeling during mechanical support.

  19. Moving receptor redirected adoptive cell therapy toward fine tuning of antitumor responses.

    PubMed

    Chicaybam, Leonardo; Bonamino, Martin Hernan

    2014-10-01

    Adoptive cell transfer (ACT) is emerging as a powerful modality of cancer treatment. While ACT has proved able to induce massive clinical responses, genetic modification of T lymphocytes further improved clinical responses obtained. One of the major current limitations of ACT is the inability to discern healthy from malignant cells, leading to on target/off tumor responses that can limit its application. We here discuss some of the approaches currently under development and potential solutions to circumvent these limitations and extend this potentially curative therapy to different tumors by targeting a variety of antigens.

  20. The 21st Century Cures Act Implications for the Reduction of Racial Health Disparities in the US Criminal Justice System: a Public Health Approach.

    PubMed

    Cole, Donna M; Thomas, Dawna Marie; Field, Kelsi; Wool, Amelia; Lipiner, Taryn; Massenberg, Natalie; Guthrie, Barbara J

    2017-11-09

    Past drug epidemics have disproportionately criminalized drug addiction among African Americans, leading to disparate health outcomes, increased rates of HIV/AIDS, and mass incarceration. Conversely, the current opioid addiction crisis in the USA focuses primarily on white communities and is being addressed as a public health problem. The 21st Century Cures Act has the potential to reduce racial health disparities in the criminal justice system through the Act's public health approach to addiction and mental health issues. The 21st Century Cures Act is a progressive step in the right direction; however, given the historical context of segregation and the criminalization of drug addiction among African Americans, the goals of health equity are at risk of being compromised. This paper discusses the implications of this landmark legislation and its potential to decrease racial health disparities, highlighting the importance of ensuring that access to treatment and alternatives to incarceration must include communities of color. In this paper, the authors explain the key components of the 21st Century Cures Act that are specific to criminal justice reform, including a key objective, which is treatment over incarceration. We suggest that without proper attention to how, and where, funding mechanisms are distributed, the 21st Century Cures Act has the potential to increase racial health disparities rather than alleviate them.

  1. The Export Trading Company Act of 1982 and the photovoltaics industry: An assessment

    NASA Technical Reports Server (NTRS)

    Enfield, S.; Laporta, C.

    1983-01-01

    The potential advantages of recent export promotion legislation for the U.S. photovoltaics industry were assessed. The provisions of the Export Trading Company Act of 1982 were reviewed and the export trade sector was surveyed to determine what impact the Act is haviang on export company activity. The photovoltaics industry was then studied to determine whether the Act offers particular advantages for promoting its product overseas.

  2. Potential impact of HITECH security regulations on medical imaging.

    PubMed

    Prior, Fred; Ingeholm, Mary Lou; Levine, Betty A; Tarbox, Lawrence

    2009-01-01

    Title XIII of Division A and Title IV of Division B of the American Recovery and Reinvestment Act (ARRA) of 2009 [1] include a provision commonly referred to as the "Health Information Technology for Economic and Clinical Health Act" or "HITECH Act" that is intended to promote the electronic exchange of health information to improve the quality of health care. Subtitle D of the HITECH Act includes key amendments to strengthen the privacy and security regulations issued under the Health Insurance Portability and Accountability Act (HIPAA). The HITECH act also states that "the National Coordinator" must consult with the National Institute of Standards and Technology (NIST) in determining what standards are to be applied and enforced for compliance with HIPAA. This has led to speculation that NIST will recommend that the government impose the Federal Information Security Management Act (FISMA) [2], which was created by NIST for application within the federal government, as requirements to the public Electronic Health Records (EHR) community in the USA. In this paper we will describe potential impacts of FISMA on medical image sharing strategies such as teleradiology and outline how a strict application of FISMA or FISMA-based regulations could have significant negative impacts on information sharing between care providers.

  3. The Eilberg Act, New Seed Immigration, and Professional Labor Markets.

    ERIC Educational Resources Information Center

    Agarwal, Vinod B.; Yochum, Gilbert R.

    1987-01-01

    Foreign born professionals, especially those educated in the U.S., have become increasingly important to U.S. labor markets. This paper assesses the general effect of the Eilberg Act (1976) and subsequent U.S. Department of Labor implementations on new seed professionals' potential immigration patterns. The act could diminish opportunities for…

  4. 48 CFR 926.7003 - Review of the procurement request.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Implementation of Section 3021 of the Energy Policy Act of 1992 926.7003 Review of the procurement request. Any Energy Policy Act procurement, including basic... potential for making Energy Policy Act awards. [60 FR 22300, May 5, 1995, as amended at 61 FR 21977, May 13...

  5. 48 CFR 926.7003 - Review of the procurement request.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Implementation of Section 3021 of the Energy Policy Act of 1992 926.7003 Review of the procurement request. Any Energy Policy Act procurement, including basic... potential for making Energy Policy Act awards. [60 FR 22300, May 5, 1995, as amended at 61 FR 21977, May 13...

  6. 48 CFR 926.7003 - Review of the procurement request.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Implementation of Section 3021 of the Energy Policy Act of 1992 926.7003 Review of the procurement request. Any Energy Policy Act procurement, including basic... potential for making Energy Policy Act awards. [60 FR 22300, May 5, 1995, as amended at 61 FR 21977, May 13...

  7. 48 CFR 926.7003 - Review of the procurement request.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Implementation of Section 3021 of the Energy Policy Act of 1992 926.7003 Review of the procurement request. Any Energy Policy Act procurement, including basic... potential for making Energy Policy Act awards. [60 FR 22300, May 5, 1995, as amended at 61 FR 21977, May 13...

  8. 48 CFR 926.7003 - Review of the procurement request.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Implementation of Section 3021 of the Energy Policy Act of 1992 926.7003 Review of the procurement request. Any Energy Policy Act procurement, including basic... potential for making Energy Policy Act awards. [60 FR 22300, May 5, 1995, as amended at 61 FR 21977, May 13...

  9. Stumpage price projections for selected Western species.

    Treesearch

    Richard W. Haynes; Kent P. Connaughton; Darius M. Adams

    1980-01-01

    The 1980 Resources Planning Act Timber Assessment and Program prepared in response to provisions of the Forest and Rangeland Renewable Resources Planning Act of 1974 (as amended by the National Forest Management Act of 1976) contains regional projections of average stumpage prices that are potentially useful in national forest planning. Their usefulness can be improved...

  10. Bright New Era in Education.

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC.

    During 1993-94, the U.S. Congress passed several initiatives that offer great potential for facilitating progress in education. These include: (1) The Goals 2000: Educate America Act; (2) Individual Education Accounts; (3) the Family Involvement Initiative; (4) the Safe Schools Act (as part of Goals 2000); (5) the School-to-Work Opportunities Act;…

  11. Indirect Relations Between Transgressive Acts and General Combat Exposure and Moral Injury.

    PubMed

    Frankfurt, Sheila B; Frazier, Patricia; Engdahl, Brian

    2017-11-01

    Moral injury describes the deleterious effects of acts of commission (e.g., killing noncombatants), omission (e.g., failing to prevent a massacre), or betrayal (i.e., by a trusted authority figure) during military service that transgress accepted behavioral boundaries and norms. Transgressive acts are proposed to lead to a guilt- and shame-based syndrome consisting of post-traumatic stress disorder (PTSD) symptoms, demoralization, self-handicapping, and self-injury. In this study, we tested a frequently cited model of moral injury and assessed the associations between potentially transgressive acts, moral injury outcomes, and guilt and fear. Additionally, we sought to clarify the relative contribution of transgressive and nontransgressive/general combat exposure to moral injury. On the basis of previous research and theory, we anticipated that the transgressive acts would be related to outcomes through guilt and that nontransgressive combat exposure would be related to outcomes through fear. Secondary analysis was conducted on data from a sample of combat-exposed male veterans at a Midwestern Veterans Affairs (VA) medical center (N = 190) who participated in a larger parent study on postdeployment readjustment. Structural equation modeling was used to test the pathways from transgressive and nontransgressive combat exposure to PTSD symptoms and suicidality through combat-related guilt and combat-related fear. The institutional review boards of the Midwestern VA medical center and the university of the affiliated researchers approved the study. In total, 38% (n = 72) of the sample reported a potentially transgressive act as one of their three worst traumatic events. The most common potentially transgressive act was killing an enemy combatant (17%; n = 32). In structural equation modeling analyses. potentially transgressive acts were indirectly related to both suicidality (β = 0.09, p < 0.01) and PTSD symptoms (β = 0.06, p < 0.05) through guilt. General combat exposure was indirectly related to PTSD through fear, β = 0.19, p < 0.01. Combat exposure was not directly or indirectly related to suicidality. Overall, these findings suggest that veterans with a history of potentially transgressive acts may present to the VA with a constellation of symptoms that are associated with combat-related guilt. Transgressive acts were identified using a qualitative approach, allowing a broader sampling of this domain. Results were limited by the use of self-report data and by gathering data from participants who were Veterans seeking compensation and pension evaluations for PTSD. The clinical implications suggest that focusing on fear-related outcomes and ignoring guilt- and shame-based reactions may lead to an incomplete case conceptualization. Clinicians working with veterans with moral injury are encouraged to prepare themselves for the discomfiting therapeutic experiences of bearing witness to and empathizing with clients' memories of their actions, which may include atrocities. Effective and empathic treatments that address the guilt and shame associated with transgressive acts are needed to adequately care for returning veterans. Reprint & Copyright © 2017 Association of Military Surgeons of the U.S.

  12. Effect of attractive interactions between polymers on the effective force acting between colloids immersed in a polymer system: Analytic liquid-state theory.

    PubMed

    Chervanyov, A I

    2016-12-28

    By making use of the polymer reference interaction site model, we analytically study the effect of attractive interactions between polymers on the effective forces acting between colloids immersed in a polymer system. The performed theoretical analysis has no restrictions with respect to the polymer density and relative sizes of the colloids and polymers. The polymer mediated (PM) potential acting between colloids is shown to significantly depend on the strength and range of the polymer-polymer interactions. In the nano-particle limit, where the colloid radius is much smaller than the polymer gyration radius, the presence of attractive polymer-polymer interactions causes only quantitative changes to the PM potential. In the opposite limit of relatively large colloids, the polymer-polymer interactions revert the sign of the total effective force acting between colloids so that this force becomes attractive at sufficiently large polymer densities. With the objective to study an intricate interplay between the attractive PM forces and steric repulsion in different polymer density regimes, we calculate the second virial coefficient B of the total effective potential acting between colloids. The dependence of B on the polymer density is discussed in detail, revealing several novel features of the PM interactions caused by the presence of attractive polymer-polymer interactions.

  13. Lithium acts as a potentiator of AMPAR currents in hippocampal CA1 cells by selectively increasing channel open probability

    PubMed Central

    Gebhardt, Christine; Cull-Candy, Stuart G

    2010-01-01

    Recent evidence suggests that lithium, which is used in the treatment of bipolar disorders, may act by influencing AMPAR properties at central glutamatergic synapses. While it is clear that lithium potentiates recombinant AMPAR responses in a subunit specific way, the origin of this potentiation is not known. We examined the effects of lithium on native AMPAR channels in CA1 pyramidal cells in hippocampal slices where AMPARs are expected to be associated with auxiliary subunits. We found that lithium produced a selective increase in single-channel open probability (Popen), with little effect on single-channel conductance or burst length. From the present and previous finding it is likely that lithium causes a reduction in the time to recovery from desensitization, resulting in the observed increase in Popen. This would be consistent with the view that lithium acts like certain other allosteric AMPAR modulators to reduce the time spent in the desensitized state, but differs from those that act by slowing dissociation of glutamate. PMID:20807790

  14. Allogeneic chimeric antigen receptor-modified cells for adoptive cell therapy of cancer.

    PubMed

    Marcus, Assaf; Eshhar, Zelig

    2014-07-01

    Chimeric antigen (or antibody) receptors (CAR) are fusion proteins typically combining an antibody-derived targeting fragment with signaling domains capable of activating immune cells. Recent clinical trials have shown the tremendous potential of adoptive cell transfer (ACT) of autologous T cells engineered to express a CD19-specific CAR targeting B-cell malignancies. Building on this approach, ACT therapies employing allogeneic CAR-expressing cytotoxic cells are now being explored. The basic principles of CAR-ACT are introduced. The potential benefits as well as problems of using allogeneic CAR-modified cells against tumor antigens are discussed. Various approaches to allogeneic CAR therapy are presented, including donor leukocyte infusion, CAR-redirected γδ T cells and natural killer cells, strategies to avoid graft-versus-host disease, modulation of lymphocyte migration, and exploitation of graft-versus-host reactivity. CAR-modified allogeneic cells have the potential to act as universal effector cells, which can be administered to any patient regardless of MHC type. Such universal effector cells could be used as an 'off-the-shelf' cell-mediated treatment for cancer.

  15. MOSFET Electric-Charge Sensor

    NASA Technical Reports Server (NTRS)

    Robinson, Paul A., Jr.

    1988-01-01

    Charged-particle probe compact and consumes little power. Proposed modification enables metal oxide/semiconductor field-effect transistor (MOSFET) to act as detector of static electric charges or energetic charged particles. Thickened gate insulation acts as control structure. During measurements metal gate allowed to "float" to potential of charge accumulated in insulation. Stack of modified MOSFET'S constitutes detector of energetic charged particles. Each gate "floats" to potential induced by charged-particle beam penetrating its layer.

  16. Learn about the EPA's Federal Technology Transfer Act Program

    EPA Pesticide Factsheets

    This act allows sharing Agency knowledge and expertise with outside partners through collaborative agreements and licensing. Potential partners can take advantage of opportunities to create or further develop solutions to environmental problems.

  17. 77 FR 15352 - Endangered and Threatened Wildlife and Plants; Expanding Incentives for Voluntary Conservation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-15

    ...; Expanding Incentives for Voluntary Conservation Actions Under the Endangered Species Act AGENCY: Fish and... Endangered Species Act. By this notice, we are inviting public comment to help us identify potential changes... notice is published under the authority of the Endangered Species Act of 1973, as amended (16 U.S.C. 1531...

  18. Potential implications of climate change on the proposed 'Waters of the United States' rule

    USDA-ARS?s Scientific Manuscript database

    Within the Clean Water Act of 1972, several terms were used to describe what waters would be legally protected under the act, including “waters of the United States.” However, these terms were not specifically defined within the act, and the U.S. Environmental Protection Agency (EPA) and U.S. Army ...

  19. Affective and Neuroendocrine Effects of Withdrawal from Chronic, Long-Acting Opiate Administration

    PubMed Central

    Hamilton, Kathryn L.; Harris, Andrew C.; Gewirtz, Jonathan C.

    2013-01-01

    Although the long-acting opiate methadone is commonly used to treat drug addiction, relatively little is known about effects of withdrawal from this drug in preclinical models. The current study examined affective, neuroendocrine, and somatic signs of withdrawal from the longer-acting methadone derivative l-alpha-acetylmethydol (LAAM) in rats. Anxiety-like behavior during both spontaneous and antagonist-precipitated withdrawal was measured by potentiation of the startle reflex. Withdrawal elevated corticosterone and somatic signs and blunted circadian variations in baseline startle responding. In addition, fear to an explicit, Pavlovian conditioned stimulus (fear-potentiated startle) was enhanced. These data suggest that anxiety-like behavior as measured using potentiated startle responding does not emerge spontaneously during withdrawal from chronic opiate exposure – in contrast to withdrawal from acute drug exposure – but rather is manifested as exaggerated fear in response to explicit threat cues. PMID:24076207

  20. 76 FR 39807 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Lepidium...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... Endangered Species Act of 1973 (Act) (16 U.S.C. 1531 et seq.), as amended, we listed Lepidium papilliferum as... authority for this action is the Endangered Species Act of 1973, as amended (16 U.S.C. 1531 et seq.). Dated... papilliferum may require, including managing for the potential effects of climate change. (3) Land use...

  1. 12 CFR 563.180 - Suspicious Activity Reports and other reports and statements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... transaction related to a money laundering activity or a violation of the Bank Secrecy Act. (2) Definitions... more that involve potential money laundering or violations of the Bank Secrecy Act. Any transaction...

  2. Aligning Existing USG RDD&D Funding Objectives with those of an Emerging Marine Based CCUS Industrial Sector...or...Vice Versa

    NASA Astrophysics Data System (ADS)

    Hayes, M.

    2016-12-01

    This article surveys USG laws, and other RDD&D funding mandate frameworks, which are related to biotic and/or abiotic Carbon Capture, Utilization, and Sequestration (CCUS) RDD&D. Prominent among the laws and other frameworks reviewed are: The Integrated Coastal and Ocean Observation Systems (ICOOS) Act of 2009, Federal Ocean Acidification Research and Monitoring (FOARAM) Act of 2009, Section 7406 of the Food, Conservation, and Energy (FCEA) Act of 2008 The National Oceanographic Partnership Act of 1997, and The National Ocean Plan This paper further explores the potential to significantly expand the USGs' related CCUS RDD&D funding potential through expanding the scope of the core CCUS technologies and/or markets definition(s) to include non-CCUS yet highly supportive marine based technologies and/or markets such as marine hyperloops and 'Blue' biochar/fertilizer respectively.

  3. Tobacco Packaging and Labeling Policies Under the U.S. Tobacco Control Act: Research Needs and Priorities

    PubMed Central

    2012-01-01

    Introduction: The Family Smoking Prevention and Tobacco Control Act (the “Act”), enacted in June 2009, gave the U.S. Food and Drug Administration authority to regulate tobacco products. The current paper reviews the provisions for packaging and labeling, including the existing evidence and research priorities. Methods: Narrative review using electronic literature search of published and unpublished sources in 3 primary areas: health warnings, constituent labeling, and prohibitions on the promotional elements of packaging. Results: The Act requires 9 pictorial health warnings covering half of cigarette packages and 4 text warnings covering 30% of smokeless tobacco packages. The Act also prohibits potentially misleading information on packaging, including the terms “light” and “mild,” and provides a mandate to require disclosure of chemical constituents on packages. Many of the specific regulatory provisions are based on the extent to which they promote “greater public understanding of the risks of tobacco.” As a result, research on consumer perceptions has the potential to shape the design and renewal of health warnings and to determine what, if any, information on product constituents should appear on packages. Research on consumer perceptions of existing and novel tobacco products will also be critical to help identify potentially misleading information that should be restricted under the Act. Conclusion: Packaging and labeling regulations required under the Act will bring the United States in line with international standards. There is an immediate need for research to evaluate these measures to guide future regulatory action. PMID:22039072

  4. Research and the Freedom of Information Act.

    ERIC Educational Resources Information Center

    Morris, Roberta A.; And Others

    1981-01-01

    Addresses the research issues raised in several Federal cases involving the Freedom of Information Act. Outlines implications for the possible abrogation of researchers' property rights to their data and the potential breach of the confidential researcher-subject relationship. (Author/APM)

  5. The Occupational Disease Prevention and Control Act of the People's Republic of China: an awareness assessment among workers at foreign-invested enterprises.

    PubMed

    Yongming, Shou; Rongzhu, Lu; Jie, Lin; Yan, Xu; Zhu, Yiliang; Schweigert, Michael

    2011-01-01

    The Occupational Disease Prevention and Control Act (ODPC-Act) of the People's Republic of China came into effect on May 1, 2002. Given the scope of foreign-invested enterprises (FIEs) in China and an unabated increasing trend of foreign investment, compliance with the ODPC-Act among FIEs is of particular interest, yet little is known. The extent to which an employer educates its workforce to understand the ODPC-Act may be a measure of an employer's compliance. Based on a 25-item questionnaire survey, we found that among 166 workers from three FIEs in Wuxi, Jiangsu Province, the majority had little knowledge regarding the ODPC-Act; many were unaware of their rights granted under the ODPC-Act. They were also unable to recognize employers' potential violations of the ODPC-Act. Improving FIE workers' awareness of the ODPC-Act is desirable.

  6. The Family and Medical Leave Act and the Public School Teacher.

    ERIC Educational Resources Information Center

    Marczely, Bernadette

    1994-01-01

    Discusses the 1993 Family and Medical Leave Act as it affects public school teachers. Discusses basic provisions, covered employers and eligible employees, employee rights under the law, employee responsibilities, and the potential effect on the teaching workforce. (SR)

  7. 29 CFR 1990.105 - Advisory committees.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CONTINUED) IDENTIFICATION, CLASSIFICATION, AND REGULATION OF POTENTIAL OCCUPATIONAL CARCINOGENS General...) and 7 of the Act, and 29 CFR part 1912, concerning any potential occupational carcinogen. The...

  8. 29 CFR 1990.105 - Advisory committees.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) IDENTIFICATION, CLASSIFICATION, AND REGULATION OF POTENTIAL OCCUPATIONAL CARCINOGENS General...) and 7 of the Act, and 29 CFR part 1912, concerning any potential occupational carcinogen. The...

  9. 29 CFR 1990.105 - Advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) IDENTIFICATION, CLASSIFICATION, AND REGULATION OF POTENTIAL OCCUPATIONAL CARCINOGENS General...) and 7 of the Act, and 29 CFR part 1912, concerning any potential occupational carcinogen. The...

  10. 29 CFR 1990.105 - Advisory committees.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) IDENTIFICATION, CLASSIFICATION, AND REGULATION OF POTENTIAL OCCUPATIONAL CARCINOGENS General...) and 7 of the Act, and 29 CFR part 1912, concerning any potential occupational carcinogen. The...

  11. 29 CFR 1990.105 - Advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) IDENTIFICATION, CLASSIFICATION, AND REGULATION OF POTENTIAL OCCUPATIONAL CARCINOGENS General...) and 7 of the Act, and 29 CFR part 1912, concerning any potential occupational carcinogen. The...

  12. Map showing mineral resource potential of the Sierra Ancha Wilderness and Salome Study Area, Gila County, Arizona

    USGS Publications Warehouse

    Otton, James K.; Light, Thomas D.; Shride, Andrew F.; Bergquist, Joel R.; Wrucke, Chester T.; Theobald, Paul K.; Duval, Joseph S.; Wilson, Dolores M.

    1981-01-01

    The Wilderness Act (Public Law 88-577, Sept. 3, 1964) and certain related Acts require the Geological Survey and the Bureau of Mines to survey certain areas on Federal lands to determine their mineral-resource potential. Results must be made available to the public and be submitted to the Administration and the Congress. These maps and reports present the results of a geologic and mineral survey of the Sierra Ancha Wilderness and Salome Study Area, Gila County, Arizona.

  13. GAO audit not apt to find pervasive fraud in CARE Act.

    PubMed

    1999-12-24

    After hearing a series of news reports suggesting financial improprieties in programs run by Ryan White CARE Act recipients, a General Accounting Office (GAO) review of the program was made. A preliminary GAO report found only a few cases of fraud in the administration of funding stemming from the CARE Act, but that the potential for fraud is very real because of the lack of safeguards. These findings are considered important since the House Commerce Committee is expected to conduct oversight hearings into further authorization of the CARE Act early in 2000.

  14. Streptomyces pactum assisted phytoremediation in Zn/Pb smelter contaminated soil of Feng County and its impact on enzymatic activities

    PubMed Central

    Ali, Amjad; Guo, Di; Mahar, Amanullah; Ma, Fang; Li, Ronghua; Shen, Feng; Wang, Ping; Zhang, Zengqiang

    2017-01-01

    Anthropogenic activities, such as industrial expansion, smelting, mining and agricultural practices, have intensified the discharge of potentially toxic trace elements (PTEs) into the environment, threatening human health and other organisms. To assist phytoremediation by sorghum in soil contaminated by smelters/mines in Feng County (FC), a pot experiment was performed to examine the phytoremediation potential of Streptomyces pactum (Act12) + biochar. The results showed that root uptake of Zn and Cd was reduced by 45 and 22%, respectively, while the uptake of Pb and Cu increased by 17 and 47%, respectively. The shoot and root dry weight and chlorophyll content improved after Act12 inoculation. β-glucosidase, alkaline phosphatase and urease activities in soil improved and antioxidant activities (POD, PAL, PPO) decreased after application of Act12 + biochar due to a reduction in stress from PTEs. BCF, TF and MEA confirmed the role of Act12 in the amelioration and translocation of PTEs. PCA analysis showed a correlation between different factors that affect the translocation of PTEs. Overall, Act12 promoted the phytoremediation of PTEs. Field experiments on Act12 + biochar may provide new insights into the rehabilitation and restoration of soils contaminated by mines. PMID:28387235

  15. Streptomyces pactum assisted phytoremediation in Zn/Pb smelter contaminated soil of Feng County and its impact on enzymatic activities

    NASA Astrophysics Data System (ADS)

    Ali, Amjad; Guo, Di; Mahar, Amanullah; Ma, Fang; Li, Ronghua; Shen, Feng; Wang, Ping; Zhang, Zengqiang

    2017-04-01

    Anthropogenic activities, such as industrial expansion, smelting, mining and agricultural practices, have intensified the discharge of potentially toxic trace elements (PTEs) into the environment, threatening human health and other organisms. To assist phytoremediation by sorghum in soil contaminated by smelters/mines in Feng County (FC), a pot experiment was performed to examine the phytoremediation potential of Streptomyces pactum (Act12) + biochar. The results showed that root uptake of Zn and Cd was reduced by 45 and 22%, respectively, while the uptake of Pb and Cu increased by 17 and 47%, respectively. The shoot and root dry weight and chlorophyll content improved after Act12 inoculation. β-glucosidase, alkaline phosphatase and urease activities in soil improved and antioxidant activities (POD, PAL, PPO) decreased after application of Act12 + biochar due to a reduction in stress from PTEs. BCF, TF and MEA confirmed the role of Act12 in the amelioration and translocation of PTEs. PCA analysis showed a correlation between different factors that affect the translocation of PTEs. Overall, Act12 promoted the phytoremediation of PTEs. Field experiments on Act12 + biochar may provide new insights into the rehabilitation and restoration of soils contaminated by mines.

  16. Transportation impact analysis gets a failing grade when it comes to climate change and smart growth

    DOT National Transportation Integrated Search

    2008-12-01

    Transportation impact analysis performed to comply with environmental impact laws (i.e., the : California Environmental Quality Act or the National Environmental Policy Act) often focuses : on only one perspective about potential impacts. That perspe...

  17. 76 FR 71033 - Federal Advisory Committee Act; Technological Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-16

    ... FEDERAL COMMUNICATIONS COMMISSION Federal Advisory Committee Act; Technological Advisory Council... Communications Commission's (FCC) Technological Advisory Council will hold a meeting on Tuesday, December 20... in progress and discuss potential agendas for the coming year. The FCC will attempt to accommodate as...

  18. Letters initiating Clean Water Act 404(c) review of mining at Pebble deposit

    EPA Pesticide Factsheets

    Correspondence between EPA and the Pebble Limited Partnership and the State of Alaska initiating review under section 404(c) of the Clean Water Act of potential adverse environmental effects associated with mining the Pebble deposit in southwest Alaska.

  19. Depletion interaction between colloids mediated by an athermal polymer blend

    NASA Astrophysics Data System (ADS)

    Chervanyov, A. I.

    2018-03-01

    We calculate the immersion energy of a colloid and the potential of the depletion interaction (DI) acting between colloids immersed in an athermal polymer blend. The developed theory has no limitations with respect to the polymer-to-colloid size ratios and polymer densities, covering, in particular, dense polymer blends. We demonstrate that in addition to the standard compressibility-induced mechanism of the DI there exists the mechanism relying on the correlations between compositional fluctuations specific to polymer blends. We quantitatively investigate this "compositional" mechanism of the DI and demonstrate that it causes significant contributions to the effective force acting between colloids. Further we show that relative significance of the contributions to the colloid immersion energy and the depletion potential caused by the above compositional mechanism strongly depends on the mass fractions of the polymer species and their size ratio. We find out that these contributions strongly affect the range of the DI, thus causing a significant increase in the absolute value of the second virial coefficient of the effective potential acting between colloids.

  20. ACTS Experiments Program

    NASA Technical Reports Server (NTRS)

    Schertler, R. J.

    1986-01-01

    An overview of the ACTS Experiments Program is presented. ACTS is being developed and will flight test the advanced technologies associated with: a Ka-band multibeam antenna, onboard signal processing and switching as well as laser communications. A nominal 3 yr experiments program is planned. Through the experiments program, the capabilities of the ACTS system will be made available to U.S. industry, university and government experimenters to test, prove the feasibility and evaluate the key ACTS system technologies. Communication modes of operation using the baseband processor and microwave switch matrix are presented, along with the antenna coverage pattern. Potential experiment categories are also presented and briefly discussed. An overall schedule of activities associated with the experiments program is outlined. Results of the ACTS Experiments Program will provide information vital to successful industry implementation of ACTS technology in a future operational system.

  1. New entity for conducting group practice offers new potential.

    PubMed

    Rich, H I

    1994-01-01

    A new form of entity, the limited liability company (LLC), may be used by physicians to conduct group practices with the tax advantages of a partnership and insulation from liability for copractitioner's acts. The author reviews the New Jersey Limited Liability Company Act.

  2. THE EPA NATIONAL EXPOSURE RESEARCH LABORATORY CHILDREN'S PESTICIDE EXPOSURE MEASUREMENT PROGRAM

    EPA Science Inventory

    The U.S. Environmental Protection Agency (EPA) National Exposure Research Laboratory (NERL) is performing research in support of the Food Quality Protection Act (FQPA) of 1996. This act requires that pesticide exposure assessments to be conducted for all potential sources, rou...

  3. 76 FR 55644 - Plumas County Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-08

    ... Community Self-Determination Act (Pub. L 110-343) (the Act) and operates in compliance with the Federal... provide advice and recommendations to the Forest Service concerning projects and funding consistent with... Cycle 2 project applications for potential funding recommendations to National Forest Supervisors. DATES...

  4. [Preventing dangerous psychotic acting out].

    PubMed

    Bouchard, Jean-Pierre

    2015-01-01

    Delusions of having been wronged, of persecution, of having a mission or order to execute, are frequently the causes of dangerous psychotic acting out. The regular clinical assessment of these patients and their treatment is essential for preventing this acting out, which can have dramatic consequences on the potential victims. If there is a treatment indication but refusal on the part of the patient to cooperate, it is necessary to resort to treatment without the patient's consent.

  5. A review of 'The Health Security Act of 1993'.

    PubMed

    Peterson, D M; Brownawell, H J

    1994-01-01

    The Health Security Act of 1993, which is now before Congress, holds the potential to effect major changes in the way health care is delivered in this country and in how that delivery is financed. This article reviews the principal provisions proposed to be contained in the act (as presented in the preliminary summary released in September 1993) and offers suggestions regarding the issues that hospital financial managers should begin addressing now.

  6. Detection of aneugenic and clastogenic potential of X-rays, directly and indirectly acting chemicals in human hepatoma (Hep G2) and peripheral blood lymphocytes, using the micronucleus assay and fluorescent in situ hybridization with a DNA centromeric probe.

    PubMed

    Darroudi, F; Meijers, C M; Hadjidekova, V; Natarajan, A T

    1996-09-01

    In human hepatoma (Hep G2) cells and peripheral blood lymphocytes (HPBL) the cytokinesis-blocked micronuclei (MN) and fluorescent in situ hybridization (FISH) assays were applied to study aneugenic and clastogenic potentials of X-rays, directly and indirectly acting chemicals. Induction of MN was studied in vitro following treatment with X-rays, directly acting chemicals, such as methylmeth-anesulphonate (MMS), colchicine (COL), vincristine sulphate (VCS) and vinblastine sulphate (VBS), and indirectly acting agents, such as cyclophosphamide (CP), hexamethylphosphoramide (HMPA), 2-acetylaminofluorene (2-AAF) and 4-acetylaminofluorene (4-AAF). Depending on the presence of the fluorescent signal in the MN following FISH with a human DNA centromeric probe, MN in the binucleated Hep G2 cells and lymphocytes were scored as centromere-positive or centromere-negative, representing an aneugenic and clastogenic event respectively. In the controls approximately 50% of spontaneously occurring MN were centromere-positive. Treatment of human hepatoma cells and HPBL (in vitro) with potent aneugens such as COL, VCS and VBS increased the number of MN in a dose-dependent manner; of these 75-93% were centromere-positive. X-irradiation induced MN in a dose-related manner in binucleated Hep G2 cells and HPBL, of which 33-40% were centromere-positive, which demonstrates the significant aneugenic potentials of X-rays. Strong clastogenic activity was observed with MMS and frequency of centromere-positive MN was low: approximately 20 and 30% for HPBL and Hep G2 cells respectively. In Hep G2 cells significant aneugenic activity was found with indirectly acting promutagens/procarcinogens such as HMPA and 2-AAF, in contrast to CP, which came out as a potent clastogen. The non-carcinogen 4-AAF was not able to induce an increase in the frequency of MN in Hep G2 cells. All indirectly acting chemicals tested came out negative when HPBL were used as targets for DNA damage. The results presented correlate positively with data from in vivo assays and indicate that the Hep G2 cell system is a suitable bioactivation system (in vitro) for evaluating the clastogenic and aneugenic potentials of chemicals which require exogenous metabolic activations in order to exert their mutagenic potential.

  7. 75 FR 80506 - Agency Forms Undergoing Paperwork Reduction Act Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-22

    .... Proposed Project Persistence of Viable Influenza Virus in Aerosols--New--National Institute for... Safety and Health Act. Influenza continues to be a major public health concern because of the substantial health burden from seasonal influenza and the potential for a severe pandemic. Although influenza is...

  8. Life in a Regulated Environment: Do You Comply with Environmental Laws?

    ERIC Educational Resources Information Center

    McKeague, Kevin J.

    1994-01-01

    Discusses the following issues: (1) implications of the Americans with Disabilities Act; (2) Asbestos Hazard Emergency Response Act regulations; (3) new lead guidelines; (4) requirements regarding underground storage tanks; (5) potential indoor air quality requirements; and (6) Occupational Safety and Health Administration guidelines. (MLF)

  9. 77 FR 45688 - Electronic Prescriptions for Controlled Substances Notice of Approved Certification Process

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-01

    ... Comprehensive Drug Abuse Prevention and Control Act of 1970, often referred to as the Controlled Substances Act... substances, particularly Schedule II controlled substances, which have a significant potential for abuse... Prescriptions for Controlled Substances Notice of Approved Certification Process AGENCY: Drug Enforcement...

  10. 77 FR 35323 - National Environmental Policy Act: Categorical Exclusions for Soil and Water Restoration Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-13

    ... Policy Act: Categorical Exclusions for Soil and Water Restoration Activities AGENCY: Forest Service, USDA... document the potential environmental effects of soil and water restoration projects that are intended to... adding three new categorical exclusions for activities that achieve soil and water restoration objectives...

  11. 78 FR 56153 - National Environmental Policy Act: Categorical Exclusions for Soil and Water Restoration Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-12

    ... Policy Act: Categorical Exclusions for Soil and Water Restoration Activities AGENCY: Forest Service, USDA... more efficiently analyze and document the potential environmental effects of soil and water restoration... achieve soil and water restoration objectives. Category 18 allows the restoration of wetlands, streams...

  12. 76 FR 13797 - Rural Broadband Access Loans and Loan Guarantees Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-14

    ... being issued prior to passage of a final appropriations act to allow potential applicants time to submit... a subsequent notice identifying the amount received in the final appropriations act, if any. At this... appropriations; however, Congress is presently reviewing budget authority across the Federal government in an...

  13. 38 CFR 200.4 - Implementation of NEPA and related authorities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... action reveals that air emissions exceed de minimis levels or otherwise that a formal Clean Air Act... RETIREMENT HOME COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 200.4 Implementation of NEPA and... aquifers (potential sources of drinking water); National Wildlife Refuges; National Parks; areas of...

  14. Individuals with Disabilities Education Act: Reauthorization Overview. CRS Report for Congress.

    ERIC Educational Resources Information Center

    Aleman, Steven R.

    This report provides an overview of programs authorized under the Individuals with Disabilities Education Act (IDEA) and discusses potential reauthorization issues. Programs include the Grants to States program, preschool program, infants and toddlers program, and discretionary grant programs. For each program, information includes fiscal year…

  15. PHYSIOLOGICALLY-BASED PHARMACOKINETICS/PHARMACODYNAMIC MODELING AND CUMULATIVE RISK ASSESSMENT: CASE STUDY FOR THE N-METHYL CARBMATE PESTICIDES

    EPA Science Inventory

    The Food Quality Protection Act of 1996 [PL 104-170: 110 STAT. 1513] requires EPA to consider potential cumulative human health risks resulting from aggregate exposure to pesticide chemicals acting through a common mechanism of toxicity. This includes all anticipated dietary e...

  16. Transportation's role in reducing U.S. greenhouse gas emissions, volume 2 : report to Congress, U.S. Department of Transportation

    DOT National Transportation Integrated Search

    2010-04-01

    This study evaluates potentially viable strategies to reduce transportation greenhouse gas (GHG) emissions. The study was mandated by the Energy Independence and Security Act (P.L. 110-140, December 2007). The Act directed the U.S. Department of Tran...

  17. 76 FR 27342 - Central Utah Project Completion Act; Notice of Intent To Accept Proposals, Select a Potential...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... DEPARTMENT OF THE INTERIOR Central Utah Project Completion Act; Notice of Intent To Accept... Interior. ACTION: Notice. SUMMARY: Current Federal policy encourages non-Federal development of... Interior (Interior), in consultation with the Department of Energy, Western Area Power Administration...

  18. Molecular Basis of Paralytic Neurotoxin Action on Voltage-Sensitive Sodium Channels

    DTIC Science & Technology

    1989-10-20

    acting at neurotoxin receptor site 2, and markedly potentiated and prolonged by polypeptide a-scorpion toxins and sea anemone toxins acting at neurotoxin...to block the actions of scorpion toxins and sea anemone toxins on the sodium channel. Transmembrane organization of amino acid sequences between

  19. Consent Agreement and Final Order Against Xutapa Properties, LLC for Safe Drinking Water Act Violations

    EPA Pesticide Factsheets

    Under Section 1423 (c) of the Safe Drinking Water Act, 42 U.S.C. § 300h-2, the EPA is assessing a civil penalty to Xutapa Properties, LLC for maintaining seven injection wells with the potential to contaminate groundwater resources.

  20. Sexual Orientation Discrimination: Teachers as Positive Role Models for Tolerance.

    ERIC Educational Resources Information Center

    Eisenmenger, Michelle

    2002-01-01

    Discusses Title VII of the Civil Rights Act of 1964 and the proposed Employment Non-Discrimination Act in terms of their potential legal remedies for victims of sexual-orientation discrimination. Examines several relevant federal appellate and Supreme Court decisions and the role of homosexual teachers. (PKP)

  1. Transportation's role in reducing U.S. greenhouse gas emissions, volume 1 : report to Congress, U.S. Department of Transportation

    DOT National Transportation Integrated Search

    2010-04-01

    This study evaluates potentially viable strategies to reduce transportation : greenhouse gas (GHG) emissions. The study was mandated by the Energy : Independence and Security Act (P.L. 110-140, December 2007). The Act directed : the U.S. Department o...

  2. Improvisational Acting Exercises and Their Potential Use in Family Counseling

    ERIC Educational Resources Information Center

    Ruby, James R.; Ruby, Nanci Carol

    2009-01-01

    Expressive therapy interventions are a useful resource for counselors working with a wide range of presenting issues. This article illustrates a series of improvisational acting exercises that can be used within a family counseling context. Clear directions for specific exercises are provided, along with illustrative case examples.

  3. Novel collection method for volatile organic compounds (VOCs) from dogs

    USDA-ARS?s Scientific Manuscript database

    Host derived chemical cues are an important aspect of arthropod attraction to potential hosts. Host cues that act over longer distances include CO2, heat, and water vapor, while cues such as volatile organic compounds (VOCs) act over closer distances. Domestic dogs are important hosts for disease cy...

  4. Notes and comments "High and dry?" The Public Readiness and Emergency Preparedness Act and liability protection for pharmaceutical manufacturers.

    PubMed

    Copper, B Kurt

    2007-01-01

    In an era filled with fears of bioterrorism, Congress approved the Public Readiness and Emergency Preparedness Act (PREPA) to encourage development of vaccines and other countermeasures. By providing pharmaceutical manufacturers with protection from liability for potential side effects, Congress has attempted to motivate manufacturers to produce a national stockpile of countermeasures. As part of PREPA, the government established a compensatory system intended to provide compensation to persons injured by countermeasures used during a public health emergency. Although the Act provides for a compensation fund, it fails to allocate monies for that fund. Thus, in the absence of further congressional action, PREPA will not provide compensation to those injured by countermeasures. Failing to assure the American public of a compensation program constitutes bad public policy and risks inspiring potential vaccinees to refuse necessary drugs. Additionally, arguments as to the constitutionality of the Act exist should Congress fail to adequately fund the program, and the existence of those arguments undermines the purpose of the Act--namely to assure pharmaceutical manufacturers that they will not be sued into oblivion should they attempt to aid national pandemic protection. In addition to detailing both the Act and the statutory precedent for congressional attempts to spur biodefense, this Article addresses important issues of healthcare, tort, and constitutional law that will continue to manifest themselves in this new era of bioterrorism.

  5. 12 CFR 7.1002 - National bank acting as finder.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... sellers, and conducting market research to identify potential new customers for retailers; (5) Conveying... and terms to potential markets for these products and services; (2) Communicating to the seller an...

  6. 12 CFR 7.1002 - National bank acting as finder.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... sellers, and conducting market research to identify potential new customers for retailers; (5) Conveying... and terms to potential markets for these products and services; (2) Communicating to the seller an...

  7. Liability of professional and volunteer mental health practitioners in the wake of disasters: a framework for further considerations.

    PubMed

    Abdel-Monem, Tarik; Bulling, Denise

    2005-01-01

    Qualified immunity from civil liability exists for acts of disaster mental health (DMH) practitioners responding to disasters or acts of terrorism. This article reviews current legal regimens dictating civil liability for potentially wrongful acts of DMH professionals and volunteers responding to disasters. Criteria are proposed to inform determinations of civil liability for DMH workers in disaster response, given current legal parameters and established tort law in relevant areas. Specific considerations are examined that potentially implicate direct liability of DMH professionals and volunteers, and vicarious liability of DMH supervisors for actions of volunteer subordinates. The relevance of pre-event DMH planning and operationalization of the plan post-event is linked to considerations of liability. This article concludes with recommendations to minimize liability exposure for DMH workers in response efforts.

  8. Nutritive evaluation and effect of Moringa oleifera pod on clastogenic potential in the mouse.

    PubMed

    Promkum, Chadamas; Kupradinun, Piengchai; Tuntipopipat, Siriporn; Butryee, Chaniphun

    2010-01-01

    Moringa oleifera Lam (horseradish tree; tender pod or fruits) has been consumed as a vegetable and utilized as a major ingredient of healthy Thai cuisine. Previous studies have shown that M. oleifera pod extracts act as bifunctional inducers along with displaying antioxidant properties and also inhibiting skin papillomagenesis in mice. This study was aimed to determine the nutritive value, and clastogenic and anticlastogenic potentials of M. oleifera pod. The nutritive value was determined according to AOAC methods. The clastogenic and anticlastogenic potentials were determined using the in vivo erythrocyte micronucleus assay in the mouse. Eighty male mice were fed semi-purified diets containing 1.5%, 3.0% and 6.0% of ground freeze-dried boiled M. oleifera pod (bMO) for 2 weeks prior to administration of both direct-acting (mitomycin C, MMC) and indirect-acting (7, 12-dimethylbenz(a)anthracene, DMBA), clastogens. Blood samples were collected at 0, 24, 48 and 72 h, dropped on acridine orange-coated slides, and then counted for reticulocytes both with and without micronuclei by fluorescence microscopy. The nutritive value of 100 g bMO consisted of: moisture content, 8.2 g; protein, 19.2 g; fat, 3.9 g; carbohydrate (dietary fiber included), 60.5 g; dietary fiber, 37.5 g; ash, 8.1 g and energy, 354 kcal. Freeze-dried boiled M. oleifera had no clastogenic activity in the mouse while it possessed anticlastogenic activity against both direct and indirect-acting clastogens. Freeze-dried boiled M. oleifera pod at 1.5%, 3.0% and 6.0% in the diets decreased the number of micronucleated peripheral reticulocytes (MNRETs) induced by both MMC and DMBA. However, the effect was statistically significant in the dose dependent manner only in the MMC-treated group. In conclusion, the present study demonstrated that bMO has no clastogenicity and possesses anticlastogenic potential against clastogens, and particularly a direct-acting clastogen in the mouse.

  9. Experiments for Ka-band mobile applications: The ACTS mobile terminal

    NASA Technical Reports Server (NTRS)

    Estabrook, Polly; Dessouky, Khaled; Jedrey, Thomas

    1990-01-01

    To explore the potential of Ka-band to support mobile satellite services, the Jet Propulsion Laboratory (JPL) has initiated the design and development of a Ka-band land-mobile terminal to be used with the Advanced Communications Technology Satellite (ACTS). The planned experimental setup with ACTS is described. Brief functional descriptions of the mobile and fixed terminals are provided. The inputs required from the propagation community to support the design activities and the planned experiments are also discussed.

  10. Mechanism of action and interactions between xanthine oxidase inhibitors derived from natural sources of chlorogenic and ferulic acids.

    PubMed

    Gawlik-Dziki, Urszula; Dziki, Dariusz; Świeca, Michał; Nowak, Renata

    2017-06-15

    The aim of this study was to estimate the phenolic composition and xanthine oxidase (XO) inhibitory activity of green coffee beans (GCB) and wholemeal wheat flour (WF). Additionally, the type and strength of interaction (expressed as the combination index, CI) and mode of XO inhibition were analyzed. The major phenolic in GCB was 5-caffeoylquinic acid (39.92mg/g dw). The main phenolic acids in WF were trans- and cis-ferulic acids (257 and 165.57mg/100g dw, respectively). Both ferulic and chlorogenic acids individually inhibited XO, and for their combination moderate synergism was found. Buffer extractable compounds from GCB and WF demonstrated slight synergism (CI=0.92), while potentially bioaccessible and bioavailable compounds acted synergistically (CI=0.43 and 0.54, respectively). Buffer-extractable and potentially bioavailable phytochemicals from GCB acted uncompetitively, whereas potentially bioaccessible compounds acted as noncompetitive XO inhibitors. The addition of 3-5% of GCB to wheat bread significantly increased XO-inhibitory activity. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. NREL Reveals Potential for Capturing Waste Heat via Nanotubes | News | NREL

    Science.gov Websites

    Reveals Potential for Capturing Waste Heat via Nanotubes News Release: NREL Reveals Potential for Capturing Waste Heat via Nanotubes April 4, 2016 A finely tuned carbon nanotube thin film has the potential to act as a thermoelectric power generator that captures and uses waste heat, according to

  12. Aryl Trifluoromethyl Iximes: potential new mosquito insecticides

    USDA-ARS?s Scientific Manuscript database

    Fluorinated methylketones have been identified as potential mosquitocides, suspected of acting as reaction coordinate analogues that inhibit acetylcholinesterase (AChE) thereby leading to paralysis and eventual death. Previous work has explored trifluoro-, difluoro-, and fluoromethylketone analogues...

  13. Adoptive cell therapy: past, present and future.

    PubMed

    Cohen, Jonathan E; Merims, Sharon; Frank, Stephen; Engelstein, Roni; Peretz, Tamar; Lotem, Michal

    2017-01-01

    The immune system is a potent inhibitor of tumor growth with curative potential, constituting in many eyes the future of antineoplastic therapy. Adoptive cell therapy (ACT) is a form of immunotherapy in which autologous cancer-cognate lymphocytes are expanded and modified ex vivo and re-infused to combat the tumor. This review follows the evolvement of ACT and treatment protocols, focusing on unresolved dilemmas regarding this treatment while providing evidence for its effectiveness in refractory patients. Future directions of ACT are discussed, in particular with regard to genetic engineering of autologous cells, and the role of ACT in the era of checkpoint inhibitors is addressed.

  14. Employment discrimination implications of genetic screening in the workplace under Title VII and the Rehabilitation Act.

    PubMed

    Canter, E F

    1984-01-01

    The emergence of genetic screening techniques will permit employers to exclude hypersusceptible individuals from potentially hazardous workplace environments. The denial of employment opportunities to these individuals, however, may constitute discrimination. This Note analyzes genetic screening cases with respect to currently available remedies contained in Title VII of the Civil Rights Act of 1964 and the Rehabilitation Act of 1973. The Note concludes that Title VII claims may succeed but only in limited circumstances and that Rehabilitation Act claims will encounter numerous obstacles to relief. Additionally, the Note discusses some of the implications of the use of genetic screening in the workplace.

  15. RECOVERY POTENTIAL AS A MEANS OF PRIORITIZING RESTORATION OF WATERS IDENTIFIED AS IMPAIRED UNDER THE CLEAN WATER ACT

    EPA Science Inventory

    The sheer number of waterbodies identified as impaired under Section 303(d) of the Clean Water Act presents states with challenging decisions on which sites to address, in what order, and with what fraction of limited restoration resources. Our goal was to demonstrate a systemat...

  16. Child Care under the Family Support Act: Early Lessons from the States.

    ERIC Educational Resources Information Center

    Children's Defense Fund, Washington, DC.

    A Children's Defense Fund (CDF) survey indicates that many AFDC families are being forced to place their children in low-quality and potentially dangerous child care. Family Support Act (FSA) childcare typically lacks basic health and safety and precautions, fails to provide sufficient assistance to support quality childcare and preschool…

  17. Individuals with Disabilities Education Act: Reauthorization Overview. CRS Report for Congress.

    ERIC Educational Resources Information Center

    Aleman, Steven R.

    This report provides a review of programs authorized under the Individuals with Disabilities Education Act (IDEA) and an overview of potential reauthorization issues, as the second session of the 103rd Congress considers revisions to these programs. The Infants and Toddlers Program (Part H of IDEA) provides formula grants to participating States…

  18. 77 FR 36581 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-19

    ... Conservation Act of 1978 AGENCY: National Science Foundation. ACTION: Notice of Permit Applications Received.... The presence of these animals pose operation safety concerns as well as potential harm to the animals... for capturing Antarctic fishes to study their physiology and biochemistry. Benthic Otter trawling is...

  19. Transportation's role in reducing U.S. greenhouse gas emissions, volume 1 and volume 2 : report to Congress, U.S. Department of Transportation

    DOT National Transportation Integrated Search

    2010-04-01

    This study evaluates potentially viable strategies to reduce transportation : greenhouse gas (GHG) emissions. The study was mandated by the Energy : Independence and Security Act (P.L. 110-140, December 2007). The Act directed : the U.S. Department o...

  20. Wage Discrimination and Comparable Worth: A Legal Perspective.

    ERIC Educational Resources Information Center

    Pinzler, Isabelle Katz; Ellis, Deborah

    1989-01-01

    Discusses ways to close the gap between the courts' approach to applying Federal law to sex-based and race-based wage discrimination and the law's potential to change wage inequities. Discusses the Equal Pay Act and Title VII of the Civil Rights Act of 1964. Explores ways the court applies these laws. (JS)

  1. 75 FR 52294 - Effective Date of Requirement for Premarket Approval for Four Class III Preamendments Devices

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-25

    ... Federal Food, Drug, and Cosmetic Act (the act), as amended by the Medical Device Amendments of 1976 (the... could lead to potentially debilitating or fatal thromboembolism. b. Excessive hemolysis--poor design of the hemodynamic characteristics of the device can lead to excess hemolysis. c. Inability to support...

  2. Workforce Development Policy: Unrealized Potential for Americans with Disabilities

    ERIC Educational Resources Information Center

    Golden, Thomas P.; Bruyere, Susanne M.; Karpur, Arun; Nazarov, Zafar; VanLooy, Sara; Reiter, Beth

    2012-01-01

    Individuals with disabilities have lower rates of workforce participation and lower earnings than their nondisabled peers. This article traces the history of the U.S. workforce development policy framework, including the Workforce Investment Act of 1998; the Rehabilitation Act of 1973, as amended; and the impact of the Ticket to Work and Work…

  3. Storytelling and Story-Acting: Co-Construction in Action

    ERIC Educational Resources Information Center

    Cremin, Teresa; Flewitt, Rosie; Swann, Joan; Faulkner, Dorothy; Kucirkova, Natalia

    2018-01-01

    In the light of sustained interest in the potential value of young children's narrative play, this article examines Vivian Gussin Paley's approach to storytelling and story-acting, in this case with 3- to 5-year-olds. It scrutinises how children's narratives are co-constructed during adult-child and peer interactions through spoken and embodied…

  4. A Monitoring and Assessment Plan for the Youth Employment and Demonstration Projects Act of 1977.

    ERIC Educational Resources Information Center

    Employment and Training Administration (DOL), Washington, DC.

    Intended as a general blueprint for monitoring and assessing activities under the Youth Employment and Demonstration Projects Act of 1977, this document discusses the expected constraints, evaluation and assessment tools, the analytic framework, and monitoring and review schedule. Five problem areas are recognized as potential constraints in…

  5. Potential Impact of Clean Air Act Regulations on Nitrogen Fate and Transport in the Neuse River Basin: a Modeling Investigation Using CMAQ and SWAT

    EPA Science Inventory

    There has been extensive analysis of Clean Air Act Amendment (CAAA) regulation impacts to changes in atmospheric nitrogen deposition; however, few studies have focused on watershed nitrogen transfer particularly regarding long-term predictions. In this study, we investigated impa...

  6. Worsening of myasthenia gravis after administration of injectable long-acting risperidone for treatment of schizophrenia; first case report and a call for caution.

    PubMed

    Al-Hashel, Jasem Y; Ismail, Ismail Ibrahim; John, John K; Ibrahim, Mohammed; Ali, Mahmoud

    2016-01-01

    Myasthenia gravis is an autoimmune disease characterized by muscle weakness due to autoantibodies affecting the neuromuscular junction. Co-occurrence of myasthenia gravis and schizophrenia is very rare and raises a challenge in management of both diseases. Antipsychotic drugs exhibit anticholinergic side effects and have the potentials of worsening myasthenia. Long-acting risperidone is an injectable atypical antipsychotic drug that has not been previously reported to worsen myasthenia gravis in literature. We report the first case report of worsening of myasthenia after receiving long-acting risperidone injection for schizophrenia in a 29-year-old female with both diseases. She started to have worsening 2 weeks following the first injection and her symptoms persisted despite receiving plasma exchange. This could be explained by the pharmacokinetics of the drug. We recommend that long-acting risperidone should be used with caution in patients with myasthenia gravis, and clinicians must be aware of the potential risks of this therapy. Copyright © 2016 Elsevier B.V. All rights reserved.

  7. Saltcedar and Russian Olive Control Demonstration Act Science Assessment

    USGS Publications Warehouse

    Shafroth, Patrick B.; Brown, Curtis A.; Merritt, David M.

    2010-01-01

    The primary intent of this document is to provide the science assessment called for under The Saltcedar and Russian Olive Control Demonstration Act of 2006 (Public Law 109-320; the Act). A secondary purpose is to provide a common background for applicants for prospective demonstration projects, should funds be appropriated for this second phase of the Act. This document synthesizes the state-of-the-science on the following topics: the distribution and abundance (extent) of saltcedar (Tamarix spp.) and Russian olive (Elaeagnus angustifolia) in the Western United States, potential for water savings associated with controlling saltcedar and Russian olive and the associated restoration of occupied sites, considerations related to wildlife use of saltcedar and Russian olive habitat or restored habitats, methods to control saltcedar and Russian olive, possible utilization of dead biomass following removal of saltcedar and Russian olive, and approaches and challenges associated with revegetation or restoration following control efforts. A concluding chapter discusses possible long-term management strategies, needs for additional study, potentially useful field demonstration projects, and a planning process for on-the-ground projects involving removal of saltcedar and Russian olive.

  8. Methodolgy for determining differential tanker rates for SPR oil movement in an energy emergency: Final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1988-09-01

    Jones Act ships must be used to move crude and petroleum products between US ports. However, if no suitable Jones Act tankers or barges are available, shippers may apply, on a case-by-case basis, for a wavier to use substantially cheaper foreign capacity instead. Case-by-case determination of these waivers creates a potential problem for an emergency drawdown of the Strategic Petroleum Reserve (SPR): potential buyers of crude would have to submit bids while facing considerable uncertainty about their ultimate costs of transporting the SPR oil. This report examines an alternative to the case-by-case waiver process, which we call a ''composite waivermore » procedure.'' The composite waiver procedure has two elements: a general waiver of the Jones Act requirement for moving SPR crude; and a rebate, equal to the price differential between foreign ships and Jones Act ships, to be paid to any buyer of SPR crude who uses US bottoms for transport. The composite waiver is designed to reduce the uncertainty surrounding transportation costs in the crude bidding process, and to keep Jones Act tankers price competitive so these vessels are not eliminated from use during an SPR emergency drawdown. 17 figs.« less

  9. 78 FR 4411 - Agency Forms Undergoing Paperwork Reduction Act Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ... potential study population is unique in that their children experienced newborn CMV screening as part of a previous research study. Universal CMV screening has not been recommended by medical associations or state.... Newborn CMV screening offers some clear potential benefits, but few studies have assessed the potential...

  10. Guidelines for determining probability of causation under the Energy Employees Occupational Illness Compensation Program Act of 2000; revision of guidelines on non-radiogenic cancers. Final rule.

    PubMed

    2012-02-06

    In a notice of proposed rulemaking published in the Federal Register on March 21, 2011, the Department of Health and Human Services (HHS) proposed to treat chronic lymphocytic leukemia (CLL) as a radiogenic cancer under the Energy Employees Occupational Illness Compensation Program Act of 2000 (EEOICPA) (76 FR 15268). Under this final rule, CLL will be treated as being potentially caused by radiation and hence as potentially compensable under EEOICPA. HHS reverses its decision to exclude CLL from such treatment.

  11. Evaluation of Inhaled Procaterol for Potential Assist Use in Patients with Stable Chronic Obstructive Pulmonary Disease.

    PubMed

    Kodaka, Norio; Yamagishi, Toru; Watanabe, Kayo; Kishimoto, Kumiko; Nakano, Chihiro; Oshio, Takeshi; Niitsuma, Kumiko; Shimada, Nagashige; Matsuse, Hiroto

    2018-05-17

    International guidelines recommend the use of long-acting bronchodilators for the treatment of chronic obstructive pulmonary disease (COPD), but the usefulness of short-acting bronchodilator assist use for stable COPD remains uncertain. The purpose of the present study was to objectively demonstrate the effects of assist use of procaterol, a short-acting -agonist, on the respiratory mechanics of stable COPD patients treated with a long-acting bronchodilator using forced oscillation technique (FOT) and conventional spirometry. We also confirmed the length of time for which procaterol assist could significantly improve pulmonary function. We enrolled 28 outpatients with mild to severe COPD (GOLD stages I-III), who had used the same long-acting bronchodilator for longer than 3 months and who were in stable condition. All measures were performed using both FOT and spirometry sequentially from 15 min to 2 h after inhalation. Compared to baseline, inhaled procaterol assist use modestly but significantly improved spirometric and FOT measurements within 2 h after inhalation. These significant effects continued for at least 2 h. Significant correlations were found between parameters measured by spirometry and those measured by FOT. Procaterol assist use modestly but significantly improved pulmonary function determined by spirometry and respiratory mechanics in patients with stable COPD treated with long-acting bronchodilators. Thus, inhaled procaterol has potential for assist use for COPD. ©2018The Author(s). Published by S. Karger AG, Basel.

  12. Warding off the evil eye: when the fear of being envied increases prosocial behavior.

    PubMed

    van de Ven, Niels; Zeelenberg, Marcel; Pieters, Rik

    2010-11-01

    The fear of being envied makes people act prosocially, in an attempt to ward off the potentially destructive effects of envy. In three experiments, people who were in a superior position and could be envied were more likely than control participants to give time-consuming advice to a potentially envious person or to help a potentially envious person pick up erasers she had accidentally scattered. However, helping behavior increased only if envy was likely to be malicious rather than benign. People who were better off did not increase their helping behavior toward people in general, but increased their helping only toward the potentially envious. This finding is consistent with the idea that the better off act more prosocially as an appeasement strategy. The fear of being envied serves useful group functions, because it triggers prosocial behavior that is likely to dampen the potentially destructive effects of envy and simultaneously helps to improve the situation of people who are worse off.

  13. Sensing and Tactile Artificial Muscles from Reactive Materials

    PubMed Central

    Conzuelo, Laura Valero; Arias-Pardilla, Joaquín; Cauich-Rodríguez, Juan V.; Smit, Mascha Afra; Otero, Toribio Fernández

    2010-01-01

    Films of conducting polymers can be oxidized and reduced in a reversible way. Any intermediate oxidation state determines an electrochemical equilibrium. Chemical or physical variables acting on the film may modify the equilibrium potential, so that the film acts as a sensor of the variable. The working potential of polypyrrole/DBSA (Dodecylbenzenesulfonic acid) films, oxidized or reduced under constant currents, changes as a function of the working conditions: electrolyte concentration, temperature or mechanical stress. During oxidation, the reactive material is a sensor of the ambient, the consumed electrical energy being the sensing magnitude. Devices based on any of the electrochemical properties of conducting polymers must act simultaneously as sensors of the working conditions. Artificial muscles, as electrochemical actuators constituted by reactive materials, respond to the ambient conditions during actuation. In this way, they can be used as actuators, sensing the surrounding conditions during actuation. Actuating and sensing signals are simultaneously included by the same two connecting wires. PMID:22319265

  14. Review of the 2015 Drug Supply Chain Security Act

    PubMed Central

    Brechtelsbauer, Erich D.; Pennell, Benjamin; Durham, Mary; Hertig, John B.; Weber, Robert J.

    2016-01-01

    The integrity of the pharmaceutical supply chain is threatened by medication counterfeiting, importation of unapproved and substandard drugs, and grey markets – all of which have the potential to distribute drug products with the potential for serious harm. On November 27, 2013, President Obama signed into law Title II of the Drug Quality and Security Act, now known as the Drug Supply Chain Security Act (DSCSA). Over the next 10 years, the DSCSA will require the pharmaceutical supply chain to implement medication tracking and tracing; serialization, verification, and detection of suspicious products; and strict guidelines for wholesaler licensing and reporting. This article reviews the important aspects of the DSCSA and outlines the role of health-system pharmacy leaders in ensuring compliance to the DSCSA. By verifying that medication supplies are free from adulteration and tampering, the DSCSA serves as a foundational law to ensure quality in providing patient-centered pharmacy services. PMID:27354753

  15. Affordable Care Act and Diabetes Mellitus.

    PubMed

    Shi, Qian; Nellans, Frank P; Shi, Lizheng

    2015-12-01

    The Affordable Care Act (ACA) has the potential for great impact on U.S. health care, especially for chronic disease patients requiring long-term care and management. The act was designed to improve insurance coverage, health care access, and quality of care for all Americans, which will assist patients with diabetes mellitus in acquiring routine monitoring and diabetes-related complication screening for better health management and outcomes. There is great potential for patients with diabetes to benefit from the new policy mandating health insurance coverage and plan improvement, Medicaid expansion, minimum coverage guarantees, and free preventative care. However, policy variability among states and ACA implementation present challenges to people with diabetes in understanding and optimizing ACA impact. This paper aims to select the most influential components of the ACA as relates to people with diabetes and discuss how the ACA may improve health care for this vulnerable population.

  16. The Analgesic Potential of Cannabinoids

    PubMed Central

    Elikottil, Jaseena; Gupta, Pankaj; Gupta, Kalpna

    2013-01-01

    Historically and anecdotally cannabinoids have been used as analgesic agents. In recent years, there has been an escalating interest in developing cannabis-derived medications to treat severe pain. This review provides an overview of the history of cannabis use in medicine, cannabinoid signaling pathways, and current data from preclinical as well as clinical studies on using cannabinoids as potential analgesic agents. Clinical and experimental studies show that cannabis-derived compounds act as anti-emetic, appetite modulating and analgesic agents. However, the efficacy of individual products is variable and dependent upon the route of administration. Since opioids are the only therapy for severe pain, analgesic ability of cannabinoids may provide a much-needed alternative to opioids. Moreover, cannabinoids act synergistically with opioids and act as opioid sparing agents, allowing lower doses and fewer side effects from chronic opioid therapy. Thus, rational use of cannabis based medications deserves serious consideration to alleviate the suffering of patients due to severe pain. PMID:20073408

  17. 78 FR 30839 - Endangered and Threatened Wildlife and Plants; Threatened Status and Designation of Critical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-23

    ... douglasii subsp. tuplashensis (White Bluffs bladderpod) under the Endangered Species Act of 1973, as amended... Federal Register. Authority The authority for this action is the Endangered Species Act of 1973, as... for the potential effects of climate change; and (d) What areas not occupied at the time of listing...

  18. Research and Legal Perspectives on the Implications of the Family Privacy Protection Act for Research and Evaluation Involving Minors.

    ERIC Educational Resources Information Center

    Renger, Ralph; Gotkin, Vicki; Crago, Marjorie; Shisslak, Catherine

    1998-01-01

    Reviews the Family Privacy Protection Act of 1995 and its potential impact on research and evaluation involving minors. Although this legislation was not passed, the issues related to both active and passive parental consent for the participation of minors in research are very much alive. (SLD)

  19. 76 FR 20721 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ... Conservation Act of 1978 (Pub. L. 95-541) AGENCY: National Science Foundation. ACTION: Notice of permit... physiology of penguins in at least two ways. First, the respiratory oxygen store is estimated to comprise one... volume is a potential mechanism for prevention of pulmonary barotrauma (``lung squeeze''). Yet the...

  20. 76 FR 20721 - Notice of Permit Applications Received Under the Antarctic Conservation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ... Conservation Act AGENCY: National Science Foundation. ACTION: Notice of permit applications received under the... Diego. The volume of the air sacs and lungs are critical to the diving physiology of penguins in at... total body O 2 stores in various species. And second, the ratio of air sac to lung volume is a potential...

  1. Toward an Objectivistic Theory of Probability

    DTIC Science & Technology

    1956-01-01

    OBJECTIVISTIC PROBABILITY THEORY 2 7 three potential acts: the individual may choose an apple, an orange or a banana . Each of these acts corresponds to a point...its veneer having begun to peel at one corner, etc., etc. Its future there-ness lies in that it may have its legs gnawed at by the new puppy in the

  2. Childhood "contagion" through media: where is the epidemiologic evidence?

    PubMed

    Van den Bulck, Jan

    2008-03-01

    There are recurring stories about children dying by accident after imitating an act or behavior they saw in the media. Reliable data to ascertain whether and to what extent this is a serious problem are largely absent. The potential for media to act as a vector for risky behaviors is a topic subject to epidemiologic inquiry.

  3. 7 CFR Exhibit E to Subpart G of... - Implementation Procedures for the Wild and Scenic Rivers Act

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 13 2012-01-01 2012-01-01 false Implementation Procedures for the Wild and Scenic... for the Wild and Scenic Rivers Act 1. Each application for financial assistance or subdivision... included in the National Wild and Scenic Rivers System, designated for potential addition to the system, or...

  4. 7 CFR Exhibit E to Subpart G of... - Implementation Procedures for the Wild and Scenic Rivers Act

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 13 2011-01-01 2009-01-01 true Implementation Procedures for the Wild and Scenic... for the Wild and Scenic Rivers Act 1. Each application for financial assistance or subdivision... included in the National Wild and Scenic Rivers System, designated for potential addition to the system, or...

  5. 7 CFR Exhibit E to Subpart G of... - Implementation Procedures for the Wild and Scenic Rivers Act

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 13 2013-01-01 2013-01-01 false Implementation Procedures for the Wild and Scenic... for the Wild and Scenic Rivers Act 1. Each application for financial assistance or subdivision... included in the National Wild and Scenic Rivers System, designated for potential addition to the system, or...

  6. 7 CFR Exhibit E to Subpart G of... - Implementation Procedures for the Wild and Scenic Rivers Act

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 13 2014-01-01 2013-01-01 true Implementation Procedures for the Wild and Scenic... for the Wild and Scenic Rivers Act 1. Each application for financial assistance or subdivision... included in the National Wild and Scenic Rivers System, designated for potential addition to the system, or...

  7. 75 FR 18877 - Notice of Invitation to Participate; Exploration for Coal in Utah License Application UTU-87041

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... the Mineral Leasing Act of 1920, as amended by section 4 of the Federal Coal Leasing Amendments Act of... reserves contained in a potential lease. The Federal coal resources are located in Emery and Sevier...] Notice of Invitation to Participate; Exploration for Coal in Utah License Application UTU-87041 AGENCY...

  8. The Job Training Partnership Act and Computer-Assisted Instruction. Research Report 88-13.

    ERIC Educational Resources Information Center

    Education Turnkey Systems, Inc., Falls Church, VA.

    A study sought to (1) determine the current and potential instructional application of computers in Job Training Partnership Act (JTPA) Titles II, III, and IV programs; and (2) present policy options that would increase the effective use of this technology in employment and training programs. Research methodology involved conducting an assessment…

  9. 77 FR 49089 - High-Cost Mortgage and Homeownership Counseling Amendments to the Truth in Lending Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-15

    ... a detailed discussion of the likely impact of the Dodd- Frank Act's amendments on HOEPA lending. \\10.... Those impacts are analyzed in the 2012 TILA-RESPA Proposal, but the Bureau believes that it is also helpful to analyze potential impacts and modifications to particular regulatory triggers on a rule- by...

  10. 77 FR 15087 - Intent To Prepare a Draft Environmental Impact Statement (DEIS) for the Installation of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-14

    ... to Section 404 of the Clean Water Act and Section 10 of the Rivers and Harbor Act, from the Village.../Projects/index.html , under the Village of Bald Head Island Terminal Groin Project. SUPPLEMENTARY... DEIS with the North Carolina Division of Water Quality (NCDWQ) to assess the potential water quality...

  11. 78 FR 32256 - Privacy Act of 1974; Report of an Altered CMS System of Records Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-29

    ... tax payers or tax filers, and spouses and parents of applicants. Due to the potential impact of the... Privacy Officer, Division of Privacy Policy, Privacy Policy and Compliance Group, Office of E-Health... Health Care and Education Reconciliation Act of 2010 (Pub. L. 111-152) (collectively referred to as the...

  12. On the (Im)potentiality of an African Philosophy of Education to Disrupt Inhumanity

    ERIC Educational Resources Information Center

    Waghid, Yusef

    2015-01-01

    Despite the advances made in the liberal Western philosophical and educational tradition to counteract unethical, immoral and inhumane acts committed by the human species, these acts of inhumanity persist. It would be inapt to apportion blame only to Western thinking, which has its roots in Greek antiquity, as Plato and Aristotle, for instance,…

  13. 76 FR 77914 - Agricultural Bioterrorism Protection Act of 2002; Biennial Review and Republication of the Select...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-15

    ... Bioterrorism Protection Act of 2002; Biennial Review and Republication of the Select Agent and Toxin List; Amendments to the Select Agent and Toxin Regulations AGENCY: Animal and Plant Health Inspection Service, USDA... proposed rule that would amend and republish the list of select agents and toxins that have the potential...

  14. Observational learning without a model is influenced by the observer's possibility to act: evidence from the Simon task.

    PubMed

    Iani, Cristina; Rubichi, Sandro; Ferraro, Luca; Nicoletti, Roberto; Gallese, Vittorio

    2013-07-01

    We assessed whether observational learning in perceptual-motor tasks is affected by the visibility of an action producing perceived environmental effects and by the observer's possibility to act during observation. To this end, we conducted three experiments in which participants were required to observe a spatial compatibility task in which only the effects of computer-generated responses were visible before executing a Simon task. In Experiment 1, we compared the effects of a passively observed practice with either a spatially compatible or incompatible stimulus-response (S-R) association. In Experiment 2, during the observed spatially incompatible practice participants were prevented from potentially acting, either because a plexiglas barrier separated the participant from the response device rendering it out of reach; or because the participant's hands were tied; or the device affording a response was absent. In Experiment 3, the plexiglas presented an opening that could allow the participant to potentially reach and interact with it. As when the practice is physically performed, we found an elimination of the Simon effect following a spatially incompatible observed practice, suggesting that participants learned an incompatible S-R association by observing and transferred this knowledge to the subsequent Simon task. No evidence of transfer of learning was found when, during passive observation, the participant's hands were tied, or a barrier prevented him/her from potentially interacting with the device, or no response device was present. Differently, a transfer-of-learning effect was observed when the barrier presented an opening. These results suggest that learning can derive from the mere observation of action effects, even when an action is not visible, as long as the observer has the potential to act. Copyright © 2013 Elsevier B.V. All rights reserved.

  15. Plant Operations. OSHA on Campus: Campus Safety Officers Discuss Problems and Potentials

    ERIC Educational Resources Information Center

    Kuchta, Joseph F.; And Others

    1973-01-01

    The Occupation Safety and Health Act (OSHA) has presented campus safety officers with new problems, but it is also offering them new potentials, which were explored at the recent national conference on Campus Security. (Editor)

  16. 77 FR 56859 - Federal Register Notification of Redesignation of Potential Wilderness as Wilderness, Ross Lake...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... Register Notification of Redesignation of Potential Wilderness as Wilderness, Ross Lake National Recreation.... ACTION: Notice of Redesignation of Potential Wilderness as Wilderness. SUMMARY: The 1988 Washington Parks Wilderness Act (Pub. L. 100-668, November 16, 1988) designated 634,614 acres of North Cascades National Park...

  17. 78 FR 44583 - Implementation of the Privacy Act of 1974, as Amended; Action To Modify and Terminate an Existing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-24

    ... the marketing of housing assets, to identify qualified potential purchasers, and to solicit bids for... based on their determination of potential returns following acquisition. In order to maximize recovery... reviewed by bidders to evaluate investment potential. The availability of this due diligence information...

  18. Recommendations for genetic testing to reduce the incidence of anthracycline-induced cardiotoxicity.

    PubMed

    Aminkeng, Folefac; Ross, Colin J D; Rassekh, Shahrad R; Hwang, Soomi; Rieder, Michael J; Bhavsar, Amit P; Smith, Anne; Sanatani, Shubhayan; Gelmon, Karen A; Bernstein, Daniel; Hayden, Michael R; Amstutz, Ursula; Carleton, Bruce C

    2016-09-01

    Anthracycline-induced cardiotoxicity (ACT) occurs in 57% of treated patients and remains an important limitation of anthracycline-based chemotherapy. In various genetic association studies, potential genetic risk markers for ACT have been identified. Therefore, we developed evidence-based clinical practice recommendations for pharmacogenomic testing to further individualize therapy based on ACT risk. We followed a standard guideline development process, including a systematic literature search, evidence synthesis and critical appraisal, and the development of clinical practice recommendations with an international expert group. RARG rs2229774, SLC28A3 rs7853758 and UGT1A6 rs17863783 variants currently have the strongest and the most consistent evidence for association with ACT. Genetic variants in ABCC1, ABCC2, ABCC5, ABCB1, ABCB4, CBR3, RAC2, NCF4, CYBA, GSTP1, CAT, SULT2B1, POR, HAS3, SLC22A7, SCL22A17, HFE and NOS3 have also been associated with ACT, but require additional validation. We recommend pharmacogenomic testing for the RARG rs2229774 (S427L), SLC28A3 rs7853758 (L461L) and UGT1A6*4 rs17863783 (V209V) variants in childhood cancer patients with an indication for doxorubicin or daunorubicin therapy (Level B - moderate). Based on an overall risk stratification, taking into account genetic and clinical risk factors, we recommend a number of management options including increased frequency of echocardiogram monitoring, follow-up, as well as therapeutic options within the current standard of clinical practice. Existing evidence demonstrates that genetic factors have the potential to improve the discrimination between individuals at higher and lower risk of ACT. Genetic testing may therefore support both patient care decisions and evidence development for an improved prevention of ACT. © 2016 The British Pharmacological Society.

  19. Recommendations for genetic testing to reduce the incidence of anthracycline‐induced cardiotoxicity

    PubMed Central

    Aminkeng, Folefac; Ross, Colin J. D.; Rassekh, Shahrad R.; Hwang, Soomi; Rieder, Michael J.; Bhavsar, Amit P.; Smith, Anne; Sanatani, Shubhayan; Gelmon, Karen A.; Bernstein, Daniel; Hayden, Michael R.; Amstutz, Ursula

    2016-01-01

    Aims Anthracycline‐induced cardiotoxicity (ACT) occurs in 57% of treated patients and remains an important limitation of anthracycline‐based chemotherapy. In various genetic association studies, potential genetic risk markers for ACT have been identified. Therefore, we developed evidence‐based clinical practice recommendations for pharmacogenomic testing to further individualize therapy based on ACT risk. Methods We followed a standard guideline development process, including a systematic literature search, evidence synthesis and critical appraisal, and the development of clinical practice recommendations with an international expert group. Results RARG rs2229774, SLC28A3 rs7853758 and UGT1A6 rs17863783 variants currently have the strongest and the most consistent evidence for association with ACT. Genetic variants in ABCC1, ABCC2, ABCC5, ABCB1, ABCB4, CBR3, RAC2, NCF4, CYBA, GSTP1, CAT, SULT2B1, POR, HAS3, SLC22A7, SCL22A17, HFE and NOS3 have also been associated with ACT, but require additional validation. We recommend pharmacogenomic testing for the RARG rs2229774 (S427L), SLC28A3 rs7853758 (L461L) and UGT1A6*4 rs17863783 (V209V) variants in childhood cancer patients with an indication for doxorubicin or daunorubicin therapy (Level B – moderate). Based on an overall risk stratification, taking into account genetic and clinical risk factors, we recommend a number of management options including increased frequency of echocardiogram monitoring, follow‐up, as well as therapeutic options within the current standard of clinical practice. Conclusions Existing evidence demonstrates that genetic factors have the potential to improve the discrimination between individuals at higher and lower risk of ACT. Genetic testing may therefore support both patient care decisions and evidence development for an improved prevention of ACT. PMID:27197003

  20. Remote observatory access via the Advanced Communications Technology Satellite

    NASA Technical Reports Server (NTRS)

    Horan, Stephen; Anderson, Kurt; Georghiou, Georghios

    1992-01-01

    An investigation of the potential for using the ACTS to provide the data distribution network for a distributed set of users of an astronomical observatory has been conducted. The investigation consisted of gathering the data and interface standards for the ACTS network and the observatory instrumentation and telecommunications devices. A simulation based on COMNET was then developed to test data transport configurations for real-time suitability. The investigation showed that the ACTS network should support the real-time requirements and allow for growth in the observatory needs for data transport.

  1. Disclosure of information to organ procurement organizations. Interim final rule.

    PubMed

    2007-08-23

    This document amends the Department of Veterans Affairs (VA) regulations to implement section 204 of the Veterans Benefits, Health Care, and Information Technology Act of 2006. This regulatory change will provide authority for VA to provide individually-identifiable VA medical records of veterans or dependents of veterans who are deceased or whose death is imminent to representatives of organ procurement organizations (OPOs) as defined in section 371(b) of the Public Health Service Act (PHS Act), eye banks, and tissue banks to determine whether the patients are suitable potential donors.

  2. The Advanced Communications Technology Satellite (ACTS) capabilities for serving science

    NASA Technical Reports Server (NTRS)

    Meyer, Thomas R.

    1990-01-01

    Results of research on potential science applications of the NASA Advanced Communications Technology Satellite (ACTS) are presented. Discussed here are: (1) general research on communications related issues; (2) a survey of science-related activities and programs in the local area; (3) interviews of selected scientists and associated telecommunications support personnel whose projects have communications requirements; (4) analysis of linkages between ACTS functionality and science user communications activities and modes of operation; and (5) an analysis of survey results and the projection of conclusions to a national scale.

  3. Update on ropivacaine.

    PubMed

    Wang, R D; Dangler, L A; Greengrass, R A

    2001-12-01

    Long-acting local anaesthetics are primarily used in the practice of anaesthesia, particularly in regional anaesthesia and analgesia. Ropivacaine is a new long-acting local anaesthetic that has been the focus of interest because of its increased cardiovascular safety compared with bupivacaine. Other advantages of ropivacaine over bupivacaine include a greater sensorimotor differential block and shorter elimination half-life (t(1/2)), with a lower potential for accumulation. The most important attribute of ropivacaine, however, is its increased margin of safety compared with bupivacaine when given in equal doses. Many post-marketing studies have focused on the comparisons of efficacy in blocks and toxicity profiles of bupivacaine versus ropivacaine. Recent animal toxicity studies confirm the results of original studies showing that ropivacaine has less cardiovascular toxicity than bupivacaine with respect to direct myocardial depression, success of resuscitation and arrhythmogenic potential when given in equal doses. Reduced cardiotoxicity may be a distinct characteristic of ropivacaine. A review of current literature suggests that, at clinically relevant doses, ropivacaine provides the lowest potential risk of cardiotoxicity for inadvertent intravascular injection. Studies are currently under way comparing ropivacaine with levobupivacaine, the latest addition to the group of long-acting local anaesthetics.

  4. Potential enterotoxicity and antimicrobial resistance pattern of Aeromonas species isolated from pet turtles and their environment.

    PubMed

    Wimalasena, S H M P; Shin, Gee-Wook; Hossain, Sabrina; Heo, Gang-Joon

    2017-05-23

    To investigate the potential enterotoxicity and antimicrobial resistance of aeromonads from pet turtles as a risk for human infection, one hundred and two Aeromonas spp. were isolated from the feces, skin and rearing environments of pet turtles and identified by biochemical and gyrB sequence analyses. Aeromonas enteropelogenes was the predominant species among the isolates (52.9%) followed by A. hydrophila (32.4%), A. dharkensis (5.9%), A. veronii (4.9%) and A. caviae (3.9%). Their potential enterotoxicities were evaluated by PCR assays for detecting genes encoding cytotoxic enterotoxin (act) and two cytotonic enterotoxins (alt and ast). 75.8% of A. hydrophila isolates exhibited the act + /alt + /ast + genotype, whereas 94.4% of A. enteropelogenes isolates were determined to be act - /alt - /ast - . In an antimicrobial susceptibility test, most isolates were susceptible to all tested antibiotics except amoxicillin, ampicillin, cephalothin, chloramphenicol and tetracycline. Non-susceptible isolates to penicillins (ampicillin and amoxicillin) and fluoroquinolones (ciprofloxacin and norfloxacin) were frequently observed among the A. enteropelogenes isolates. Few isolates were resistant to imipenem, amikacin, ceftriaxone and cefotaxime. Collectively, these results suggest that pet turtles may pose a public health risk of infection by enterotoxigenic and antimicrobial resistant Aeromonas strains.

  5. Data bank has operational impact. Proper peer review can protect hospitals from antitrust and defamation suits.

    PubMed

    Purtell, D L

    1990-11-01

    The Health Care Quality Improvement Act of 1986 can help protect medical professionals and healthcare facilities from antitrust and defamation claims and other forms of litigation arising from the peer review process. Some hospitals may need to make major changes in their peer review activity as a result of the act. The healthcare entity, not the physicians involved in peer review, has the burden of complying with the provisions of the act. Failure to comply with the act can lead to loss of immunity from damages, fines, and potential exclusion from the Medicare program. The potential for liability has sparked a need for hospitals to reexamine and possibly reorganize medical staff and update procedures and related governing documents. Healthcare entities may consider changes such as implementing a director of medical affairs function, choosing medical staff for multiple-year terms, and centralizing physician review files. In the 1980s many hospitals created quality assurance and risk management programs. Risk managers need to share data with quality assurance personnel, who must in turn share the information with medical staff involved with credentialing, peer review, and medical affairs management. Legal counsel will need to be familiar with the legalities of the act, as well as the hospital's peer review procedures and operations. General legal counsel should oversee coordination of hospital proceedings and assist in educating staff on the legalities of peer review.

  6. Uses of Video in Understanding and Improving Mathematical Thinking and Teaching

    ERIC Educational Resources Information Center

    Schoenfeld, Alan H.

    2017-01-01

    This article characterizes my use of video as a tool for research, design and development. I argue that videos, while a potentially overwhelming source of data, provide the kind of large bandwidth that enables one to capture phenomena that one might otherwise miss; and that although the act of taping is in itself an act of selection, there is…

  7. Forest resources of the United States, 2002: mapping the renewable resource planning act data

    Treesearch

    Cassandra M. Kurtz; Daniel J. Kaisershot; Dale D. Gormanson; Jeffery S. Wazenegger

    2009-01-01

    Forest Inventory and Analysis (FIA), a national program of the Forest Service, U.S. Department of Agriculture conducts and maintains comprehensive inventories of the forest resources in the United States. The Forest and Rangeland Renewable Resources Planning Act (RPA) of 1974 mandates a comprehensive assessment of past trends, current status, and the future potential...

  8. Vermont's Act 60: Comprehensive School Finance Reform--Effects in the First Year of Full Implementation.

    ERIC Educational Resources Information Center

    Mathis, William J.; Fleming, Brenda L.

    Vermont's Act 60 received national attention not only because of the controversy surrounding the sharing pool (or recapture provision) but also because of its "potential for being the most equitable system in the country." For fiscal years 1998 to 2001, tax rates have become more equitable, and a direct relationship has appeared between…

  9. Linking global scenarios to national assessments: Experiences from the Resources Planning Act (RPA) Assessment

    Treesearch

    Linda L. Langner; Peter J. Ince

    2012-01-01

    The Resources Planning Act (RPA) Assessment provides a nationally consistent analysis of the status and trends of the Nation's renewable forest resources. A global scenario approach was taken for the 2010 RPA Assessment to provide a shared world view of potential futures. The RPA Assessment scenarios were linked to the global scenarios and climate projections used...

  10. Tropical forestry research at the USDA Forest Service's Institute of Pacific Island Forestry

    Treesearch

    C. Eugene Conrad; Jerry A. Sesco

    1992-01-01

    Deforestation during the last decade has grown at an alarming rate, giving rise to concern for its potential adverse effects on global climate. The impetus for focusing greater emphasis on tropical forestry management and research was provided by the International Forestry Cooperation Act enacted into law in 1990. The Act enables the Forest Service to intensify its...

  11. A Way Forward: A Progressive Vision for Reauthorizing the Elementary and Secondary Education Act

    ERIC Educational Resources Information Center

    Ayers, Jeremy; Brown, Cynthia

    2011-01-01

    Congress has the opportunity to move forward on education reform by reauthorizing the Elementary and Secondary Education Act, or ESEA, to ensure all children achieve their greatest potential. Unfortunately, it has yet to find the will to do so, to the detriment of American students and schools. ESEA is the largest and most significant federal…

  12. Determining "What Works": An Interview with Dr. Grover "Russ" Whitehurst

    ERIC Educational Resources Information Center

    Mageau, Therese

    2004-01-01

    Much of the discussion in the news, schools and statehouses about the NO Child Left Behind Act has focused on testing and accountability, and whether there is enough money to fund the act sufficiently. However, bubbling underneath this publicity is a term that has the potential to cause a minor ripple on the surface or to erupt like ah underwater…

  13. Industrial Arts in Vocational Legislation: An Analysis of the Carl D. Perkins Vocational Education Act of 1984.

    ERIC Educational Resources Information Center

    Dyrenfurth, Michael J.

    The Vocational Education Act of 1984 offers considerable opportunity for industrial arts. Because modern industrial arts (and agricultural arts) are listed as being eligible for funding from the Basic State Grant, Part B, most attention will be focused on this goal. Other Part B uses of funds with potential for industrial arts involvement include…

  14. Language Problems and the Final Act. Esperanto Documents, New Series No. 11A.

    ERIC Educational Resources Information Center

    Universal Esperanto Association, Rotterdam (Netherlands).

    The Final Act of the Conference on Security and Co-operation in Europe, linguistic problems in the way of cooperation, language differences and the potential for discriminatory practice, and the need for a new linguistic order are discussed. It is suggested that misunderstandings arising from differences of language reduce the ability of the 35…

  15. Assessing Teacher Effectiveness through Dual-Rater Classroom Observations: Researchers and District Staff Partnering to Create Calibrated Performance Evaluations

    ERIC Educational Resources Information Center

    Manzeske, David P.; Eno, Jared P.; Stonehill, Robert M.; Cumming, John M.; MacGillivary, Heather L.

    2014-01-01

    Federal policies (e.g., 2002 reauthorization of the Elementary and Secondary Education Act [ESEA] and the American Recovery and Reinvestment Act) posit that teacher quality is a potential leverage point for improving student achievement (U.S. Department of Education, 2010). Moreover, in the Race to the Top competition, teacher effectiveness must…

  16. The Development of a Teacher Salary Parcel Tax: The Quality Teacher and Education Act in San Francisco

    ERIC Educational Resources Information Center

    Hough, Heather J.; Loeb, Susanna

    2009-01-01

    This case study will serve primarily as an historical account detailing the development of Quality Teacher and Education Act (QTEA). QTEA and the most salient details that led to its eventual passage, serving as an information source for San Francisco Unified School District (SFUSD) and other districts when they take on potentially controversial…

  17. Analysis of Oblique Wave Interaction with a Comb-Type Caisson Breakwater

    NASA Astrophysics Data System (ADS)

    Wang, Xinyu; Liu, Yong; Liang, Bingchen

    2018-04-01

    This study develops an analytical solution for oblique wave interaction with a comb-type caisson breakwater based on linear potential theory. The fluid domain is divided into inner and outer regions according to the geometrical shape of breakwater. By using periodic boundary condition and separation of variables, series solutions of velocity potentials in inner and outer regions are developed. Unknown expansion coefficients in series solutions are determined by matching velocity and pressure of continuous conditions on the interface between two regions. Then, hydrodynamic quantities involving reflection coefficients and wave forces acting on breakwater are estimated. Analytical solution is validated by a multi-domain boundary element method solution for the present problem. Diffusion reflection due to periodic variations in breakwater shape and corresponding surface elevations around the breakwater are analyzed. Numerical examples are also presented to examine effects of caisson parameters on total wave forces acting on caissons and total wave forces acting on side plates. Compared with a traditional vertical wall breakwater, the wave force acting on a suitably designed comb-type caisson breakwater can be significantly reduced. This study can give a better understanding of the hydrodynamic performance of comb-type caisson breakwaters.

  18. Targeting GPR120 and other fatty acid sensing GPCRs ameliorates insulin resistance and inflammatory diseases

    PubMed Central

    Talukdar, Saswata; Olefsky, Jerrold M; Osborn, Olivia

    2011-01-01

    The last decade has seen great progress in the understanding of the molecular pharmacology, physiological function and therapeutic potential of the G protein-coupled receptors. Free Fatty acids (FFAs) have been demonstrated to act as ligands of several GPCRs including GPR40, GPR43, GPR84, GPR119 and GPR120. We have recently shown that GPR120 acts as a physiological receptor of ω3 fatty acids in macrophages and adipocytes, which mediate potent anti-inflammatory and insulin sensitizing effects. The important role GPR120 plays in the control of inflammation raises the possibility that targeting this receptor could have therapeutic potential in many inflammatory diseases including obesity and type 2 diabetes. In this review, we discuss lipid-sensing GPCRs and highlight potential outcomes of targeting such receptors in ameliorating disease. PMID:21663979

  19. Leadership styles, emotion regulation, and burnout.

    PubMed

    Arnold, Kara A; Connelly, Catherine E; Walsh, Megan M; Martin Ginis, Kathleen A

    2015-10-01

    This study investigated the potential impact of leadership style on leaders' emotional regulation strategies and burnout. Drawing on the full-range model of leadership and Conservation of Resources (COR) theory, we tested whether transformational, contingent reward, management by exception-active and -passive, or laissez-faire leadership exert direct effects on leaders' reported use of surface acting, deep acting, and genuine emotion. In turn, we hypothesized and tested the indirect effect of leadership on burnout through surface acting. Three waves of data from 205 leaders were analyzed using OLS regression. Transformational leadership predicted deep acting and genuine emotion. Contingent reward predicted both surface and deep acting. Management by exception-active and -passive predicted surface acting, and laissez faire predicted genuine emotion. The indirect effects of management by exception-active and -passive on burnout through surface acting were not significant. Indirect effects of transformational leadership and laissez-faire on burnout through genuine emotion, however, were significant. This study provides empirical evidence for the hypothesized relationships between leadership style, emotion regulation, and burnout, and provides the basis for future research and theory building on this topic. (c) 2015 APA, all rights reserved).

  20. Broncho-Vaxom and spontaneous allergic autocytotoxicity (spACT) in bronchial asthma associated with food hypersensitivity.

    PubMed

    Podleski, W K

    1986-01-01

    Spontaneous allergic autocytotoxicity (spACT) of white blood cells (WBC) was assessed in six bronchial asthma patients and eighteen normal control individuals. The observed alterations of non-primed WBC membrane were revealed as an increased uptake of trypan blue exclusion dye, an indicator of death cells. The phenomenon of spACT might be associated with a lack of T suppressor cell intervention, increased refractoriness of WBC membrane leading to its increased permeability and enhanced releasability of chemical mediators of anaphylaxis, which probably bypasses IgE events. In six bronchial asthma patients, three were sensitive toward wheat, two had cow milk sensitivity, and one had corn sensitivity. When WBC of these patients were studied in the direct ACT assay, an additional augmentation of spACT effect by specific food antigens was observed. Surprisingly, Broncho-Vaxom (BX) did not inhibit or enhance spACT. However, BX has antagonistic activity toward direct ACT response in the dose-dependent concentration as previously reported. Our preliminary clinical experience leads us to believe that the spACT assay can serve as a useful clinical discriminator of potential responders versus non-responders to therapy with new agents, when WBC disintegration by autoinduction is involved.

  1. 7 CFR 170.6 - How are potential market participants identified for the USDA Farmers Market?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) MISCELLANEOUS MARKETING PRACTICES UNDER THE AGRICULTURAL MARKETING ACT OF 1946 USDA...? Potential market participants are recruited by AMS market management through local farm organizations in the...

  2. DEVELOPMENTAL EVALUATION OF A POTENTIAL NON-STEROIDAL ESTROGEN: TRICLOSAN

    EPA Science Inventory

    Triclosan is an antibacterial agent commonly used in industry and often detected in wastewater effluent. The potential of triclosan to act as an endocrine disruptor was examined because its chemical structure closely resembles known non-steroidal estrogens (e.g. DES, bis-phenol A...

  3. Advances in evidence-based cancer adoptive cell therapy.

    PubMed

    Ge, Chunlei; Li, Ruilei; Song, Xin; Qin, Shukui

    2017-04-01

    Adoptive cell therapy (ACT) has been developed in cancer treatment by transferring/infusing immune cells into cancer patients, which are able to recognize, target, and destroy tumor cells. Recently, sipuleucel-T and genetically-modified T cells expressing chimeric antigen receptors (CAR) show a great potential to control metastatic castration-resistant prostate cancer and hematologic malignancies in clinic. This review summarized some of the major evidence-based ACT and the challenges to improve cell quality and reduce the side effects in the field. This review also provided future research directions to make sure ACT widely available in clinic.

  4. A guide to the EEOC's final regulations on the Americans with Disabilities Act.

    PubMed

    Shaller, E H; Rosen, D A

    The Equal Employment Opportunity Commission (EEOC) recently issued its final regulations on the Americans with Disabilities Act (ADA). Although the regulations offer some guidance for employers on how to comply with the Act, they fail to provide specific answers to the many complicated compliance questions that will surely arise. Further, the regulations are almost totally silent on certain critical issues related to insurance, workers' compensation, and potential conflicts between ADA obligations and terms of collective bargaining agreements. The EEOC has essentially left the resolution of many important ADA questions to case-by-case determination and the litigation process.

  5. Some green for some green in West Virginia: An overview of the West Virginia Conservation and Preservation Easements Act

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1997-11-01

    The West Virginia Conservation and Preservation Act is a land management device whose time has come in West Virginia. Wise use of this tool by lawyers, property owners and holding entities can help the state to achieve a balance between the wise use of its natural resources and the promotion of tourism. Although not appropriate in every situation where it could potentially be applied, the West Virginia Act is a device by which economic and environmental interests can converge for the benefit of both parties.

  6. The patient protection and affordable care act: what does it mean for mental health services for older adults?

    PubMed

    Sorrell, Jeanne M

    2012-11-01

    The U.S. Supreme Court recently upheld the constitutionality of the Patient Protection and Affordable Care Act (PPACA). It is important to think about how this act will affect mental health services for older adults. The act has the potential to improve health outcomes across all income and age groups. There are specific provisions that are expected to improve care for individuals with mental illness, but there is little information about how these provisions will affect older adults with mental illness. As we move toward implementation of the PPACA, psychiatric nurses need to be aware of myths surrounding the act and to think about changes in the health care system, such as collaborative models of care, that may help identify and overcome barriers to treatment of older adults with mental illness. Copyright 2012, SLACK Incorporated.

  7. The Family and Medical Leave Act--key provisions and potential problems.

    PubMed

    Shaller, E H; Qualiana, M K

    1993-01-01

    The recently enacted Family and Medical Leave Act requires larger employers to provide eligible employees with up to twelve weeks of unpaid leave for certain medical and family-related reasons. This article addresses who the law applies to; the circumstances when leave must be granted; how the leave period is supposed to be scheduled; various notice, scheduling, medical certification, and reporting requirements; reinstatement and continuation-of-benefits requirements; and other key provisions of the Act. The basic requirements of the Act are not complicated, but certain issues that are not addressed by the Act or its legislative history--such as what qualifies as a serious health condition justifying a leave, when an intermittent or reduced schedule leave may be taken and how such schedules are determined, and how differences with state family and medical leave laws are to be reconciled--will have to be resolved by administrative regulation or litigation.

  8. [Why is it necessary to review the December 15th 2003 circular relative to the transfusion act?].

    PubMed

    Lassale, B; Besse-Moreau, M; Aullen, J-P

    2014-11-01

    Blood transfusion is currently a delegated medical act in patient care services. Following severe adverse events, hemovigilance now disposes of a dense regulation. Data collection and analysis in the national hemovigilance "e-FIT" database allow detection of errors or malfunctions in the transfusion act. Blood transfusion safety depends on the strict respect of processes from the prescription of blood products and required patient immuno-hematology exams to the administration of blood products and follow-up of the patient. In the circular relative to the transfusion act, many steps of the transfusion process, less explicit, can be interpreted differently by health care professionals and thus lead to errors or severe adverse events. Standardization of procedures for the transfusion act and its surveillance would increase their safety and avoid potential risks for the patient. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  9. Liars and Ghosts in the House of Congress: Frank's "Ad Hominem" Arguments in the Case against the Defense of Marriage Act.

    ERIC Educational Resources Information Center

    Clarke, Lynn E.

    2000-01-01

    Offers a critical analysis of Rep. Barney Frank's speech delivered in the House of Representatives concerning the "Defense of Marriage Act." Argues that Frank attempts to persuade colleagues by advancing two "ad hominem" arguments, one of which could potentially shift the focus from the need to defend marriages from same-sex…

  10. Medicaid's Role in Financing Health Care for Children with Behavioral Health Care Needs in the Special Education System: Implications of the Deficit Reduction Act

    ERIC Educational Resources Information Center

    Mandell, David S.; Machefsky, Aliza; Rubin, David; Feudtner, Chris; Pita, Susmita; Rosenbaum, Sara

    2008-01-01

    Background: Recent changes to Medicaid policy may have unintended consequences in the education system. This study estimated the potential financial impact of the Deficit Reduction Act (DRA) on school districts by calculating Medicaid-reimbursed behavioral health care expenditures for school-aged children in general and children in special…

  11. Electronic Mail, Privacy, and the Electronic Communications Privacy Act of 1986: Technology in Search of Law.

    ERIC Educational Resources Information Center

    Samoriski, Jan H.; And Others

    1996-01-01

    Attempts to clarify the status of e-mail privacy under the Electronic Communications Privacy Act of 1986 (ECPA). Examines current law and the paucity of definitive case law. A review of cases and literature suggests there is a gap in the existing ECPA that allows for potentially abusive electronic monitoring and interception of e-mail,…

  12. Community Environmental Response Facilitation Act (CERFA) Report, Nike Battery Kansas City 30, Pleasant Hill, Missouri

    DTIC Science & Technology

    1994-04-01

    environment . * A number of environmentally significant operation identified through Enhanced PA investigations have the potential to affect human health...and environment and represent areas requiring environmental evaluation. Additional investigation, such as sampling of a variety of media including...Best Available. Copy AD-A281 929 IIIIIIIIII•. Community Environmental Response Facilitation Act (CERFA) Report Nike Battery Kansas City 30 Pleasant

  13. Privacy: The Small and Large of It

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NUSBAUM,ANNA W.

    1999-10-22

    The topic of Privacy is complex, multi-faceted, and often emotionally laden. This paper will cover the following topics, in an effort to further understanding of federal regulations and activities, the balancing act that necessarily occurs in business, and what role a records manager can play. The topics are: Definitions; The Privacy Act; ''Private'' companies; Potential areas of concern; Expectations; Corporate responsibilities; Case studies; and Records Manager's role.

  14. The Best Ways of Teaching English to Children: Using Children's Operas in Teaching to 5- to 6-Year-Old Children

    ERIC Educational Resources Information Center

    Achkasova, Natalya

    2013-01-01

    This article invites teachers to consider how to strengthen links between English, music, arts, and acting, maximizing the potential for children to become successful language learners at a young age. It will show how children's opera can act as a catalyst for learning and using the language. The findings demonstrate that teaching English with a…

  15. Cultural and Organizational Aspects of Application of the Americans with Disabilities Act to Persons with Psychiatric Disabilities

    PubMed Central

    Mechanic, David

    1998-01-01

    The Americans with Disabilities Act (ADA) requires employers to provide reasonable accommodation for persons with psychiatric disabilities. Most persons with a history of mental disorder work productively and do not require accommodation. Many persons with serious mental illness need accommodation but are conscientious and productive workers. Difficulties inherent in the Equal Employment Opportunity Commission (EEOC) guidelines are those of differentiating aspects of mental disorder from work-related conduct and the potential for manipulative persons to use the Act to excuse inappropriate behavior and ask for accommodation. A further problem is the potential for discouraging employers from hiring persons with mental illness because of the perceived difficulty of terminating them should their work prove unsatisfactory. If the ADA is to be effective, it must be seen as only one step in a larger process involving public education, effective mediation, meaningful assistance for employers, and wise implementation decisions that account appropriately for the social context. PMID:9510898

  16. Cultural and organizational aspects of application of the Americans with Disabilities Act to persons with psychiatric disabilities.

    PubMed

    Mechanic, D

    1998-01-01

    The Americans with Disabilities Act (ADA) requires employers to provide reasonable accommodation for persons with psychiatric disabilities. Most persons with a history of mental disorder work productively and do not require accommodation. Many persons with serious mental illness need accommodation but are conscientious and productive workers. Difficulties inherent in the Equal Employment Opportunity Commission (EEOC) guidelines are those of differentiating aspects of mental disorder from work-related conduct and the potential for manipulative persons to use the Act to excuse inappropriate behavior and ask for accommodation. A further problem is the potential for discouraging employers from hiring persons with mental illness because of the perceived difficulty of terminating them should their work prove unsatisfactory. If the ADA is to be effective, it must be seen as only one step in a larger process involving public education, effective mediation, meaningful assistance for employers, and wise implementation decisions that account appropriately for the social context.

  17. Reprogramming the tumor microenvironment to enhance adoptive cellular therapy.

    PubMed

    Beavis, Paul A; Slaney, Clare Y; Kershaw, Michael H; Gyorki, David; Neeson, Paul J; Darcy, Phillip K

    2016-02-01

    The frontiers of cancer immunotherapy are extending in terms of both the range of cancer types that can potentially be targeted and the types of therapeutics that are in clinical development. The use of adoptive cellular therapy (ACT) and its derivative, chimeric antigen receptor (CAR) T cells, is currently limited to hematological malignancies and immunogenic cancers such as melanoma and renal cell carcinoma. Although ACT utilizing ex vivo expanded tumor-infiltrating lymphocytes (TIL) or engineered CAR/TCR T cells have undergone clinical trials for other solid cancers, their efficacy to date has been limited. This may be due, in part, to the immunosuppressive nature of the tumor microenvironment. The development of novel combination approaches which target the immunosuppressive network engineered by tumors has raised the possibility of using ACT for a broader range of cancers. This review summarizes the potential of such strategies and outlines the clinical relevance of these observations. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. 20 CFR 10.739 - What kind of objective evidence of a potential Federal crime must exist for coverage to be extended?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...-Federal Law Enforcement Officers § 10.739 What kind of objective evidence of a potential Federal crime... potential Federal crime must exist for coverage to be extended? 10.739 Section 10.739 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL EMPLOYEES' COMPENSATION ACT CLAIMS...

  19. 25 CFR 224.137 - What must the Director do if a tribe's noncompliance has resulted in harm or the potential for...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... resulted in harm or the potential for harm to a physical trust asset? 224.137 Section 224.137 Indians... AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Periodic Reviews... potential for harm to a physical trust asset? If, because of the tribe's noncompliance with Federal law or...

  20. Ketamine and phencyclidine: the good, the bad and the unexpected

    PubMed Central

    Lodge, D; Mercier, M S

    2015-01-01

    The history of ketamine and phencyclidine from their development as potential clinical anaesthetics through drugs of abuse and animal models of schizophrenia to potential rapidly acting antidepressants is reviewed. The discovery in 1983 of the NMDA receptor antagonist property of ketamine and phencyclidine was a key step to understanding their pharmacology, including their psychotomimetic effects in man. This review describes the historical context and the course of that discovery and its expansion into other hallucinatory drugs. The relevance of these findings to modern hypotheses of schizophrenia and the implications for drug discovery are reviewed. The findings of the rapidly acting antidepressant effects of ketamine in man are discussed in relation to other glutamatergic mechanisms. PMID:26075331

  1. The relationship between deliberate self-harm behavior, body dissatisfaction, and suicide in adolescents: current concepts

    PubMed Central

    Greydanus, Donald E; Apple, Roger W

    2011-01-01

    Deliberate self-harm (DSH) is a common though often hidden condition in children and adolescents that may result in suicide. This discussion covers several aspects of DSH including its prevalence, etiology, and management. The relationships of DSH to body dissatisfaction and suicide are specifically considered. Even though most cases of DSH do not end in overt suicide, DSH reflects that potential underlying psychological pathophysiology, and likelihood of eventual death from self-murder, cannot always be predicted or prevented. It is important to take all acts of DSH as serious, and to offer comprehensive management to prevent future acts of DSH and potential suicide. PMID:21811385

  2. Migration and differentiation potential of stem cells in the cnidarian Hydractinia analysed in eGFP-transgenic animals and chimeras.

    PubMed

    Künzel, Timo; Heiermann, Reinhard; Frank, Uri; Müller, Werner; Tilmann, Wido; Bause, Markus; Nonn, Anja; Helling, Matthias; Schwarz, Ryan S; Plickert, Günter

    2010-12-01

    To analyse cell migration and the differentiation potential of migratory stem cells in Hydractinia, we generated animals with an eGFP reporter gene stably expressed and transmitted via the germline. The transgene was placed under the control of two different actin promoters and the promoter of elongation factor-1α. One actin promoter (Act-II) and the EF-1α promoter enabled expression of the transgene in all cells, the other actin promoter (Act-I) in epithelial and gametogenic cells, but not in the pluripotent migratory stem cells. We produced chimeric animals consisting of histocompatible wild type and transgenic parts. When the transgene was under the control of the epithelial cell specific actin-I promoter, non-fluorescent transgenic stem cells immigrated into wild type tissue, stopped migration and differentiated into epithelial cells which then commenced eGFP-expression. Migratory stem cells are therefore pluripotent and can give rise not only to germ cells, nematocytes and nerve cells, but also to epithelial cells. While in somatic cells expression of the act-I promoter was restricted to epithelial cells it became also active in gametogenesis. The act-I gene is expressed in spermatogonia, oogonia and oocytes. In males the expression pattern showed that migratory stem cells are the precursors of both the spermatogonia and their somatic envelopes. Comparative expression studies using the promoters of the actin-II gene and the elongation factor-1α gene revealed the potential of transgenic techniques to trace the development of the nervous system. Copyright © 2010 Elsevier Inc. All rights reserved.

  3. THIRD-GENERATION FOAM BLOWING AGENTS FOR FOAM INSULATION

    EPA Science Inventory

    The report gives results of a study of third-generation blowing agents for foam insulation. (NOTE: the search for third-generation foam blowing agents has led to the realization that, as the number of potential substitutes increases, new concerns, such as their potential to act a...

  4. DEVELOPMENTAL EVALUATION OF A POTENTIAL NON-STEROIDAL ESTROGEN: TRICLOSAN. (R827098)

    EPA Science Inventory

    Abstract

    Triclosan is an antibacterial agent commonly used in industry and often detected in wastewater effluent. The potential of triclosan to act as an endocrine disruptor was examined because its chemical structure closely resembles known non-steroidal estrogens (e....

  5. Expansion of tumor-infiltrating lymphocytes and their potential for application as adoptive cell transfer therapy in human breast cancer.

    PubMed

    Lee, Hee Jin; Kim, Young-Ae; Sim, Chan Kyu; Heo, Sun-Hee; Song, In Hye; Park, Hye Seon; Park, Suk Young; Bang, Won Seon; Park, In Ah; Lee, Miseon; Lee, Jung Hoon; Cho, Yeon Sook; Chang, Suhwan; Jung, Jaeyun; Kim, Jisun; Lee, Sae Byul; Kim, Sung Youl; Lee, Myeong Sup; Gong, Gyungyub

    2017-12-26

    Adoptive cell transfer (ACT) of ex vivo expanded tumor-infiltrating lymphocytes (TILs) has been successful in treating a considerable proportion of patients with metastatic melanoma. In addition, some patients with several other solid tumors were recently reported to have benefited clinically from such ACT. However, it remains unclear whether ACT using TILs is broadly applicable in breast cancer, the most common cancer in women. In this study, the utility of TILs as an ACT source in breast cancers was explored by deriving TILs from a large number of breast cancer samples and assessing their biological potentials. We successfully expanded TILs ex vivo under a standard TIL culture condition from over 100 breast cancer samples, including all breast cancer subtypes. We also found that the information about the percentage of TIL and presence of tertiary lymphoid structure in the tumor tissues could be useful for estimating the number of obtainable TILs after ex vivo culture. The ex vivo expanded TILs contained a considerable level of central memory phenotype T cells (about 20%), and a large proportion of TIL samples were reactive to autologous tumor cells in vitro . Furthermore, the in vitro tumor-reactive autologous TILs could also function in vivo in a xenograft mouse model implanted with the primary tumor tissue. Collectively, these results strongly indicate that ACT using ex vivo expanded autologous TILs is a feasible option in treating patients with breast cancer.

  6. Expansion of tumor-infiltrating lymphocytes and their potential for application as adoptive cell transfer therapy in human breast cancer

    PubMed Central

    Lee, Hee Jin; Kim, Young-Ae; Sim, Chan Kyu; Heo, Sun-Hee; Song, In Hye; Park, Hye Seon; Park, Suk Young; Bang, Won Seon; Park, In Ah; Lee, Miseon; Lee, Jung Hoon; Cho, Yeon Sook; Chang, Suhwan; Jung, Jaeyun; Kim, Jisun; Lee, Sae Byul; Kim, Sung Youl; Lee, Myeong Sup; Gong, Gyungyub

    2017-01-01

    Adoptive cell transfer (ACT) of ex vivo expanded tumor-infiltrating lymphocytes (TILs) has been successful in treating a considerable proportion of patients with metastatic melanoma. In addition, some patients with several other solid tumors were recently reported to have benefited clinically from such ACT. However, it remains unclear whether ACT using TILs is broadly applicable in breast cancer, the most common cancer in women. In this study, the utility of TILs as an ACT source in breast cancers was explored by deriving TILs from a large number of breast cancer samples and assessing their biological potentials. We successfully expanded TILs ex vivo under a standard TIL culture condition from over 100 breast cancer samples, including all breast cancer subtypes. We also found that the information about the percentage of TIL and presence of tertiary lymphoid structure in the tumor tissues could be useful for estimating the number of obtainable TILs after ex vivo culture. The ex vivo expanded TILs contained a considerable level of central memory phenotype T cells (about 20%), and a large proportion of TIL samples were reactive to autologous tumor cells in vitro. Furthermore, the in vitro tumor-reactive autologous TILs could also function in vivo in a xenograft mouse model implanted with the primary tumor tissue. Collectively, these results strongly indicate that ACT using ex vivo expanded autologous TILs is a feasible option in treating patients with breast cancer. PMID:29371915

  7. The Emerging Role of Chronic Low-Grade Inflammation in the Pathophysiology of Polycystic Ovary Syndrome.

    PubMed

    Shorakae, Soulmaz; Teede, Helena; de Courten, Barbora; Lambert, Gavin; Boyle, Jacqueline; Moran, Lisa J

    2015-07-01

    Polycystic ovary syndrome (PCOS) has become increasingly common over recent years and is associated with reproductive features as well as cardiometabolic risk factors, including visceral obesity, dyslipidemia and impaired glucose homeostasis, and potentially cardiovascular disease. Emerging evidence suggests that these long-term metabolic effects are linked to a low-grade chronic inflammatory state with the triad of hyperinsulinemia, hyperandrogenism, and low-grade inflammation acting together in a vicious cycle in the pathophysiology of PCOS. Dysregulation of the sympathetic nervous system may also act as an important component, potentially creating a tetrad in the pathophysiology of PCOS. The aim of this review is to examine the role of chronic inflammation and the sympathetic nervous system in the development of obesity and PCOS and review potential therapeutic options to alleviate low-grade inflammation in this setting. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  8. Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases.

    PubMed

    Talukdar, Saswata; Olefsky, Jerrold M; Osborn, Olivia

    2011-09-01

    The past decade has seen great progress in the understanding of the molecular pharmacology, physiological function and therapeutic potential of G-protein-coupled receptors (GPCRs). Free fatty acids (FFAs) have been demonstrated to act as ligands of several GPCRs including GPR40, GPR43, GPR84, GPR119 and GPR120. We have recently shown that GPR120 acts as a physiological receptor of ω3 fatty acids in macrophages and adipocytes, which mediate potent anti-inflammatory and insulin sensitizing effects. The important role GPR120 plays in the control of inflammation raises the possibility that targeting this receptor could have therapeutic potential in many inflammatory diseases including obesity and type 2 diabetes. In this review paper, we discuss lipid-sensing GPCRs and highlight potential outcomes of targeting such receptors in ameliorating disease. Copyright © 2011 Elsevier Ltd. All rights reserved.

  9. The Advanced Communications Technology Satellite - Performance, Reliability and Lessons Learned

    NASA Technical Reports Server (NTRS)

    Krawczyk, Richard J.; Ignaczak, Louis R.

    2000-01-01

    The Advanced Communications Satellite (ACTS) was conceived and developed in the mid- 1980s as an experimental satellite to demonstrate unproven Ka-band technology, and potential new commercial applications and services. Since launch into geostationary orbit in September 1993. ACTS has accumulated almost seven years of essentially trouble-free operation and met all program objectives. The unique technology, service experiments. and system level demonstrations accomplished by ACTS have been reported in many forums over the past several years. As ACTS completes its final experiments activity, this paper will relate the top-level program goals that have been achieved in the design, operation, and performance of the particular satellite subsystems. Pre-launch decisions to ensure satellite reliability and the subsequent operational experiences contribute to lessons learned that may be applicable to other comsat programs.

  10. Long-acting injectable hormonal dosage forms for contraception.

    PubMed

    Wu, Linfeng; Janagam, Dileep R; Mandrell, Timothy D; Johnson, James R; Lowe, Tao L

    2015-07-01

    Although great efforts have been made to develop long-acting injectable hormonal contraceptives for more than four decades, few long-acting injectable contraceptives have reached the pharmaceutical market or even entered clinical trials. On the other hand, in clinical practice there is an urgent need for injectable long-acting reversible contraceptives which can provide contraceptive protection for more than 3 months after one single injection. Availability of such products will offer great flexibility to women and resolve certain continuation issues currently occurring in clinics. Herein, we reviewed the strategies exploited in the past to develop injectable hormonal contraceptive dosages including drug microcrystal suspensions, drug-loaded microsphere suspensions and in situ forming depot systems for long-term contraception and discussed the potential solutions for remaining issues met in the previous development.

  11. Youth Councils and Comprehensive Youth Planning: A Report from Eight Communities. School-to-Work Intermediary Project. Issue Brief.

    ERIC Educational Resources Information Center

    Kazis, Richard

    This report focuses on the potential of Workforce Investment Act Youth Councils (YCs) to become proponents of and planners for coordinated youth services and to advocate for improved outcomes for in-school and out-of-school youth, whether a person qualifies for services under the act or not. The study reviews plans and strategies of YCs in these…

  12. A Profile of Women Potentially Eligible for the Displaced Homemaker Program under the Comprehensive Employment and Training Act of 1978.

    ERIC Educational Resources Information Center

    Shaw, Lois B.

    In recent years considerable concern has been expressed for the plight of the displaced homemaker, a women who, after spending many years working in the home, must reenter the labor market to provide the primary support for a family. In 1978 Congress added to Title 3 of the Comprehensive Employment and Training Act a special program to assist…

  13. The Children's Internet Protection Act and E-Rate Policies in Louisiana: A Comparison of Policy Interpretations in Region III and Their Impact on Learning Opportunities of Secondary Students

    ERIC Educational Resources Information Center

    Gautreaux, Madge L.

    2013-01-01

    In 2000, President Bill Clinton enacted the "Children's Internet Protection Act" (CIPA) which requires all K-12 schools and publicly funded libraries to use Internet filters to protect children from pornography and other obscene or potentially harmful online content as a stipulation for receiving E-Rate funding. The varying…

  14. Determining the Role of Language and Culture in First Nations Schools: A Comparison of the First Nations Education Act with the Policy of the Assembly of First Nations

    ERIC Educational Resources Information Center

    Morcom, Lindsay A.

    2014-01-01

    In this article, I explore the incongruence between the federal government's proposed First Nations Education Act and the approach of the Assembly of First Nations (AFN) regarding language and culture education. I also examine research concerning potential outcomes of their approaches to determine what would be most beneficial to learners.…

  15. Installation Restoration Program. Phase 1: Records Search, Sheppard AFB, Texas

    DTIC Science & Technology

    1984-02-01

    Environmental Response, Compensation, and Liability Act (CIERA) of 1980, by Executive Order 12316, and 40 Ci 300 Subpart F (National Contingency Plan). CCLA...hensive Environmental Response, Compensation, and Liability Act of 1980 (CURCLA). A potentially hazardous waste is one which is suspected of being...site for agricultural purposes to prevent food chain contamination. Silvicultural use Restrict the use of the site for silvi- cultural uses (root

  16. Validation of Passive Sampling Devices for Monitoring of Munitions Constituents in Underwater Environments

    DTIC Science & Technology

    2017-09-01

    Compensation, and Liability Act (CERCLA) and U.S. Environmental Policy Act (USEPA) requirements to protect both human health /safety and...former VNTR is based on potential risks to human health and the environment identified via the CERCLA process, together with applicable or relevant and...evaluation. National Oceanic and Atmospheric Administration Data. Isla de Vieques. U.S. Department of Health and Human Services, Agency for Toxic

  17. Open to the Public: How Communities, Parents, and Students Assess the Impact of the "No Child Left Behind Act," 2004-2007--"The Realities Left Behind"

    ERIC Educational Resources Information Center

    Stanik, Mary, Ed.

    2007-01-01

    Accountability for educating all children to their full potential is essential, but this particular goal of the No Child Left Behind (NCLB) Act cannot be achieved unless policymakers address fundamental issues of resources, capacities and will within the public education system. Over a three-year period, the Public Education Network (PEN), in…

  18. Taking 'control': Federal energy regulatory Commission policy on acquisitions of electric utility securities

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bloom, David I.; O'Brien, Angela D.

    2009-05-15

    Section 203 of the Federal Power Act remains subject to considerable uncertainty. Therefore, it is important to keep several rules in mind. Each potential acquisition must be separately analyzed under Section 203(a)(1) and 203(a)(2) of the Act. A proposed acquisition that is exempt or preapproved under one provision may still require prior FERC approval under the other one. (author)

  19. SCADA Application for ACTS Technology

    NASA Technical Reports Server (NTRS)

    Fairbanks, Barry

    1992-01-01

    The results of a system level study done by Hughes Network Systems for NASA are presented. For the supervisory control and data acquisition (SCADA) application, use of Ka-band spot beam satellite technology associated with NASA's Advanced Communication Technology Satellite (ACTS) offers a reduction in Earth station antenna size and transmitter power that may translate into lower system costs. The approaches taken to determine commercial potential of the system are described.

  20. GABAA receptor: Positive and negative allosteric modulators.

    PubMed

    Olsen, Richard W

    2018-01-31

    gamma-Aminobutyric acid (GABA)-mediated inhibitory neurotransmission and the gene products involved were discovered during the mid-twentieth century. Historically, myriad existing nervous system drugs act as positive and negative allosteric modulators of these proteins, making GABA a major component of modern neuropharmacology, and suggesting that many potential drugs will be found that share these targets. Although some of these drugs act on proteins involved in synthesis, degradation, and membrane transport of GABA, the GABA receptors Type A (GABA A R) and Type B (GABA B R) are the targets of the great majority of GABAergic drugs. This discovery is due in no small part to Professor Norman Bowery. Whereas the topic of GABA B R is appropriately emphasized in this special issue, Norman Bowery also made many insights into GABA A R pharmacology, the topic of this article. GABA A R are members of the ligand-gated ion channel receptor superfamily, a chloride channel family of a dozen or more heteropentameric subtypes containing 19 possible different subunits. These subtypes show different brain regional and subcellular localization, age-dependent expression, and potential for plastic changes with experience including drug exposure. Not only are GABA A R the targets of agonist depressants and antagonist convulsants, but most GABA A R drugs act at other (allosteric) binding sites on the GABA A R proteins. Some anxiolytic and sedative drugs, like benzodiazepine and related drugs, act on GABA A R subtype-dependent extracellular domain sites. General anesthetics including alcohols and neurosteroids act at GABA A R subunit-interface trans-membrane sites. Ethanol at high anesthetic doses acts on GABA A R subtype-dependent trans-membrane domain sites. Ethanol at low intoxicating doses acts at GABA A R subtype-dependent extracellular domain sites. Thus GABA A R subtypes possess pharmacologically specific receptor binding sites for a large group of different chemical classes of clinically important neuropharmacological agents. Copyright © 2018 Elsevier Ltd. All rights reserved.

  1. 75 FR 21258 - Privacy Act of 1974; System of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-23

    ..., and potential as a military career officer. Also used to document faculty contributions as part of the...(s) and address: Delete entry and replace with ``Chief, Software Engineering Branch, U.S. Military..., motivation, discipline, final standing and potential as a military career officer. Also used to document...

  2. 76 FR 76640 - Telecommunications Act Accessibility Guidelines; Electronic and Information Technology...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-08

    ... benefits and costs, and recommended alternatives. The Board also invites the public to identify any gaps in... guidelines, alternative policies to those presented, and information on benefits and costs. After reviewing... with considerable potential cost in relation to the benefit. Because this requirement potentially would...

  3. Potential for application of corneal retinal potential measurements to detect alcohol and drug use : a report to Congress

    DOT National Transportation Integrated Search

    1988-05-01

    This report was prepared by the Department of Transportation's National Highway Traffic Safety Administration (NHTSA) in response to Section 203 of the Highway Safety Act of 1987 (P.L. 100-17; April 1987). Congress authorized the Secretary of Transpo...

  4. Mitigating Litigation for Adventure Recreation Operators: The Ski Safety Act

    ERIC Educational Resources Information Center

    Brgoch, Shea; Lower, Leeann M.

    2017-01-01

    Adventure tourism is a rapidly growing segment of the tourism industry, which can be regarded as specific activities that are alluring for their uncertain and potentially dangerous outcomes. Risk-taking attitudes and behaviors may be common among adventure recreationists and increase the potential for litigation against recreation operators. In…

  5. 17 CFR 165.9 - Criteria for determining amount of award.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... the harm caused by the violations of the Commodity Exchange Act, including assisting the authorities... potential monetary sanctions were reduced or eliminated by the Commission because an entity self-reported a... amount of harm or potential harm caused by the underlying violations, the type of harm resulting from or...

  6. Outpatient Treatment of the Sexually Motivated Murderer and Potential Murderer.

    ERIC Educational Resources Information Center

    Schlesinger, Louis B.; Revitch, Eugene

    1990-01-01

    Introduces the psychopathology and psychodynamics of sex murderer (and potential sex murderer) with emphasis on treatment in outpatient setting. Reviews system of classification of murder based on motivational dynamics of the act itself. Presents three cases that demonstrate a treatment failure, successful treatment of a catathymic sex murderer,…

  7. Introducing the Action Potential to Psychology Students

    ERIC Educational Resources Information Center

    Simon-Dack, Stephanie L.

    2014-01-01

    For this simple active learning technique for teaching, students are assigned "roles" and act out the process of the action potential (AP), including the firing threshold, ion-specific channels for ions to enter and leave the cell, diffusion, and the refractory period. Pre-post test results indicated that students demonstrated increased…

  8. METHYLATED ARSENICIII SPECIES ARE POTENTIAL PROXIMATE OR ULTIMATE GENOTOXIC FORMS OF ARSENIC

    EPA Science Inventory

    METHYLATED ARSENIC(III) SPECIES ARE POTENTIAL PROXIMATE OR UL TIMA TE GENOTOXIC FORMS OF ARSENIC

    Inorganic arsenic (iAs, arsenite and arsenate) has been thought to act as a genotoxicant without reacting directly with DNA; neither iAs nor As(V) methylated metabolites are e...

  9. An Evaluation of the Human Carcinogenic Potential of Ethylene Glycol Butyl Ether (Egbe)

    EPA Science Inventory

    This position paper, An Evaluation of the Human Carcinogenic Potential of Ethylene Glycol Butyl Ether, was developed in support of the EPA's evaluation of a petition from the American Chemistry Council requesting to delist EGBE per the Clean Air Act Amendments (CAAA), Titl...

  10. The sunshine act and medical publications: Guidance from professional medical associations.

    PubMed

    Toroser, Dikran; DeTora, Lisa; Cairns, Angela; Juneja, Renu; Georgieva, Anna; Weigel, Al; Pepitone, Kim

    2015-01-01

    To review guidance from professional medical associations to physicians on the Sunshine Act, with a focus on industry support for medical publications. Using 'Sunshine Act' as a search term, we searched PubMed (dates February 2013 to November 2014) and the 'grey literature' using Google and Google Scholar. Online information was extracted from websites of pre-identified professional medical associations. Some professional medical associations have published peer-reviewed recommendations, position statements or general advice on their websites and in journals around the Sunshine Act. Associations also provided broad online educational resources for physicians. There was universal agreement between peer-reviewed publications, including guidelines, for the need for full transparency and disclosure of industry support. Surveys by some professional associations showed variance in opinion on the forecasted impact of the Sunshine Act on physician-industry relationships. There was scarce information specifically related to reporting requirements for industry-supported medical publications. There is a shortage of information for physicians from professional associations regarding the Sunshine Act and support for medical publications. Due to the lack of clear guidance regarding support for publications, there are presently varying interpretations of the Sunshine Act. The literature debates the potential impact of the Sunshine Act and expresses some concerns that physician-enabled innovation in drug development may be hindered.

  11. Maps showing mines, quarries, prospects, and exposures in the Otter Creek Wilderness, Randolph and Tucker counties, West Virginia

    USGS Publications Warehouse

    Behum, Paul T.; Mory, Peter C.

    1981-01-01

    The Wilderness Act (Public Law 88-577, September 3, 1964) and related acts require the U.S. Geological Survey and the U.S. Bureau of Mines to survey certain areas on Federal lands to determine their mineral resource potential. The act also directs that results of such surveys be made available to the public and be submitted to the Administration and the Congress. This report presents a part of the results of a mineral survey of the Otter Creek Wilderness, Randolph and Tucker counties, West Virginia, which was established as a wilderness by Public Law 93-622, January 3, 1975.

  12. A meta-analysis of dropout rates in acceptance and commitment therapy.

    PubMed

    Ong, Clarissa W; Lee, Eric B; Twohig, Michael P

    2018-05-01

    Many psychotherapies, including cognitive behavioral therapy and acceptance and commitment therapy (ACT), have been found to be effective interventions for a range of psychological and behavioral health concerns. Another aspect of treatment utility to consider is dropout, as interventions only work if clients are engaged in them. To date, no research has used meta-analytic methods to examine dropout in ACT. Thus, the objectives of the present meta-analysis were to (1) determine the aggregate dropout rate for ACT in randomized controlled trials, (2) compare dropout rates in ACT to those in other psychotherapies, and (3) identify potential moderators of dropout in ACT. Our literature search yielded 68 studies, representing 4,729 participants. The weighted mean dropout rates in ACT exclusive conditions and ACT inclusive conditions (i.e., those that included an ACT intervention) were 15.8% (95% CI: 11.9%, 20.1%) and 16.0% (95% CI: 12.5%, 19.8%), respectively. ACT dropout rates were not significantly different from those of established psychological treatments. In addition, dropout rates did not vary by client characteristics or study methodological quality. However, master's-level clinicians/therapists (weighted mean = 29.9%, CI: 17.6%, 43.8%) were associated with higher dropout than psychologists (weighted mean = 12.4%, 95% CI: 6.7%, 19.4%). More research on manipulable, process variables that influence dropout is needed. Copyright © 2018 Elsevier Ltd. All rights reserved.

  13. The endangered species act: science, policy, and politics.

    PubMed

    Bean, Michael J

    2009-04-01

    The Endangered Species Act of 1973 is one of the nation's most significant and most controversial environmental laws. Over three-and-a-half decades, it has profoundly influenced both private and federal agency behavior. As the scope of that influence has come to be recognized, a law that is ostensibly to be guided by science has inevitably become entangled in politics. The generality of many of the law's key provisions has produced continuing uncertainty and conflict over some basic issues. Among these are what species or other taxa are potentially subject to the Act's protections, what the extent of those protections is, and whether the Act's ultimate goal of recovery is one that is being effectively achieved. New challenges face the administrators of this law, including that of incorporating climate change considerations into the decisions made under the Act, and responding to the information made available by recent advances in genetics. This paper provides a brief overview of the Endangered Species Act's history and its key provisions, and a more in-depth look at some of the current and recurrent controversies that have attended its implementation.

  14. The Job Training Partnership Act. Potential for Program Improvements but National Job Training Strategy Needed. Testimony before the Subcommittee on Employment, Housing, and Aviation, Committee on Government Operations, House of Representatives.

    ERIC Educational Resources Information Center

    Crawford, Clarence C.

    This report records the testimony presented by Clarence C. Crawford, Associate Director, Education and Employment Issues, Human Resources, of the General Accounting Office, on the effectiveness of Title IIA of the Job Training Partnership Act (JTPA) in meeting the employment and training needs of economically disadvantaged adults and youth. His…

  15. A smart "sense-act-treat" system: combining a ratiometric pH sensor with a near infrared therapeutic gold nanocage.

    PubMed

    Shi, Peng; Liu, Zhen; Dong, Kai; Ju, Enguo; Ren, Jinsong; Du, Yingda; Li, Zhengqiang; Qu, Xiaogang

    2014-10-01

    Herein, we design a "sense-act-treat" system via the combination of a ratiometric pH sensor with a therapeutic gold nanocage. Our design could "sense" the tumor through two-state switching of fluorescence and further provide chemotherapy and hyperthermia for "treating" the tumor, showing the potential for future biomedical applications. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Installation Restoration Program. Phase 1 - Records Search, Robins AFB, Georgia.

    DTIC Science & Technology

    1982-04-01

    Installations U under the provisions of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) of 1980. PURPOSE AND SCOPE OF THE... Liability Act of 1980 (CERCLA). A potentially hazardous waste is one which is suspected of being hazardous although insufficient data are available to...comprised of a concrete vault buried approximately six feet below the ground surface. 4 A locked chain -linked fence with two barbed wire strands surrounds

  17. Environmental Symposium Held in Crystal City, Virginia on May 5-6, 1992

    DTIC Science & Technology

    1992-05-01

    addition, the Act creat a new program designed to prevent sudden, accidental releases of extremely hazardo substances . Generally, the Act sets forth a... prevent of sudden, The owner or operator of any facility handling an extremely hazardous substance will also be required to prepare and implement a risk...management plan to detect and prevent or minimize the potential for an accidental release of extremely hazardous substances . EPA may require that such

  18. Elementary and Secondary Education Act: Potential Effects of Changing Comparability Requirements. Report to the Chairman, Committee on Health, Education, Labor, and Pensions, U.S. Senate. GAO-11-258

    ERIC Educational Resources Information Center

    Scott, George A.

    2011-01-01

    For fiscal year 2010, Congress appropriated $14.5 billion for Title I, Part A of the Elementary and Secondary Education Act of 1965 (ESEA), which funds services to students in schools with high concentrations of students from low-income families. Title I, Part A includes several fiscal requirements, which are designed to prevent local school…

  19. The Essential Process for a Successful Rural Strategy. A Policy Statement Following a National Evaluation of Title V of the Rural Development Act of 1972.

    ERIC Educational Resources Information Center

    Cornman, John M.; Madden, J. Patrick

    During its three-year pilot period, Title V of the Rural Development Act of 1972 demonstrated its potential as part of a broad national rural strategy and should be carefully expanded with special attention to funding, organization, and evaluation policies. Initial funding at $20 million yearly would provide each state with $100,000 (an amount…

  20. The munitions provisions of the Federal Facility Compliance Act

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kimmell, T.A.; Green, D.R.; Queen, R.

    1994-03-01

    The Federal Facility Compliance Act (FFCA) was signed by President Bush on October 6, 1992. This Act amends the Resource Conservation and Recovery Act (RCRA), the primary law governing hazardous waste management in the US The most significant provision of the FFCA was the waiver of sovereign immunity. This waiver subjects Federal facilities to the same ``incentives`` as the private sector for compliance. While the waiver has broad implications for all Federal facilities, other provisions of the FFCA impact specific sectors of the Federal complex. The focus of this paper is the FFCA Munitions Provisions, which have the potential tomore » change some aspects of the structure of munitions management within the military. The Munitions Provisions, contained in Section 107 of the FFCA, modifies Section 3004 of RCRA by adding a new subsection (y) on Munitions. Section 107 requires the Environmental Protection Agency (EPA) to develop, after consultation with the Department of Defense (DOD) and appropriate State officials, regulations identifying when military munitions (including conventional and chemical munitions) become hazardous waste, and to provide for the safe transportation and storage of such waste. The FFCA requires EPA to promulgate the final ``Munitions Rule`` by October 6, 1994. These are the only provisions of the FFCA that require a new rulemaking. It is clear that the Munitions Rule could have a significant effect on the way in which DOD manages munitions. Demilitarization, range management, training activities, and emergency response actions may be affected. It is important for DOD, the Services, and individual installations, to be aware of potential impacts of the FFCA on munitions management operations. The purpose of this paper is to review several important munitions Rule issues, and to discuss potential impacts of these issues.« less

  1. Class Acts: How Teachers Awaken Potential = Docentes al habla: Revelar a los alumnos el tesoro de su potencial = Performances d'enseignants: Comment eveiller un potential qui dort.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France).

    This publication presents portraits of nine teachers from Argentina, Brazil, Canada, France, Jordan, Myanmar, New Zealand, Senegal, and Trinidad and Tobago who are opening up young minds and nurturing their potential. The portraits describe how these teachers created an educational situation in which students could thrive and grow. Some of the…

  2. An expert panel approach to assessing potential effects of bull trout reintroduction on federally listed salmonids in the Clackamas River, Oregon

    Treesearch

    Bruce G. Marcot; Chris S. Allen; Steve Morey; Dan Shively; Rollie White

    2012-01-01

    The bull trout Salvelinus confluentus is an apex predator in native fish communities in the western USA and is listed as threatened under the U.S. Endangered Species Act (ESA). Restoration of this species has raised concerns over its potential predatory impacts on native fish fauna. We held a five-person expert panel to help determine potential...

  3. Dedicated clock/timing-circuit theories of time perception and timed performance.

    PubMed

    van Rijn, Hedderik; Gu, Bon-Mi; Meck, Warren H

    2014-01-01

    Scalar Timing Theory (an information-processing version of Scalar Expectancy Theory) and its evolution into the neurobiologically plausible Striatal Beat-Frequency (SBF) theory of interval timing are reviewed. These pacemaker/accumulator or oscillation/coincidence detection models are then integrated with the Adaptive Control of Thought-Rational (ACT-R) cognitive architecture as dedicated timing modules that are able to make use of the memory and decision-making mechanisms contained in ACT-R. The different predictions made by the incorporation of these timing modules into ACT-R are discussed as well as the potential limitations. Novel implementations of the original SBF model that allow it to be incorporated into ACT-R in a more fundamental fashion than the earlier simulations of Scalar Timing Theory are also considered in conjunction with the proposed properties and neural correlates of the "internal clock".

  4. 77 FR 16501 - Certain Preventive Services Under the Affordable Care Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-21

    ...This advance notice of proposed rulemaking announces the intention of the Departments of Health and Human Services, Labor, and the Treasury to propose amendments to regulations regarding certain preventive health services under provisions of the Patient Protection and Affordable Care Act (Affordable Care Act). The proposed amendments would establish alternative ways to fulfill the requirements of section 2713 of the Public Health Service Act and companion provisions under the Employee Retirement Income Security Act and the Internal Revenue Code when health coverage is sponsored or arranged by a religious organization that objects to the coverage of contraceptive services for religious reasons and that is not exempt under the final regulations published February 15, 2012. This document serves as a request for comments in advance of proposed rulemaking on the potential means of accommodating such organizations while ensuring contraceptive coverage for plan participants and beneficiaries covered under their plans (or, in the case of student health insurance plans, student enrollees and their dependents) without cost sharing.

  5. Childhood Bestiality: A Potential Precursor to Adult Interpersonal Violence

    ERIC Educational Resources Information Center

    Hensley, Christopher; Tallichet, Suzanne E.; Dutkiewicz, Erik L.

    2010-01-01

    Although bestiality is an infrequent form of animal cruelty, the possibility of identifying a potential link between these acts and later interpersonal violence is an area of research that deserves further exploration. In a replication of the Hensley, Tallichet, and Singer study and based on survey data from male inmates at a medium- and…

  6. Human Pluripotent Stem Cell-Based Assay Predicts Developmental Toxicity Potential of ToxCast Chemicals (ACT meeting)

    EPA Science Inventory

    Worldwide initiatives to screen for toxicity potential among the thousands of chemicals currently in use require inexpensive and high-throughput in vitro models to meet their goals. The devTOX quickPredict platform is an in vitro human pluripotent stem cell-based assay used to as...

  7. Attitudes of School Foodservice Directors about the Potential Benefits of School Wellness Policies

    ERIC Educational Resources Information Center

    Longley, Carol; Sneed, Jeannie

    2009-01-01

    Purpose/Objectives: The Reauthorization Act of 2004 requires schools participating in the National School Lunch and School Breakfast Programs to establish a wellness policy. The purpose of this study was to examine school foodservice directors' attitudes about the potential benefits of the wellness policy. Methods: A survey research design was…

  8. The Practice of Mentoring: Reflecting on the Critical Aspects for Leadership Development

    ERIC Educational Resources Information Center

    Hicks, Deborah

    2011-01-01

    Mentorship is often considered one of the best ways to develop leadership potential in new library and information professionals. Mentors act as teacher, role model, and cheerleader, but there are potentially serious aspects to mentorships that will negatively impact the protege. Such negatives include mentors sabotaging or taking credit for a…

  9. INHIBITION OF BRAIN CHOLINESTERASE AND THE PHOTIC AFTER DISCHARGE OF FLASH EVOKED POTENTIALS PRODUCED BY CARBARYL IN LONG EVANS RATS.

    EPA Science Inventory

    Carbaryl is a widely used N-methyl carbamate pesticide that acts by inhibiting cholinesterases (ChE), which may lead to cholinergic toxicity. Flash evoked potentials (FEPs) are a neurophysiological response often used to detect central nervous system (CNS) changes following expos...

  10. BRAIN CHOLINESTERASE INHIBITION PRODUCED BY PROPOXUR AND DEPRESSION OF THE PHOTIC AFTER DISCHARGE OF FLASH EVOKED POTENTIALS IN LONG EVANS RATS.

    EPA Science Inventory

    Propoxur is a widely used N-methyl carbamate pesticide that acts by inhibiting cholinesterases (ChE), which may lead to cholinergic toxicity. Flash evoked potentials (FEPs) are a neurophysiological response following stimulation of the visual system with flashes of light. They ar...

  11. 7 CFR 170.6 - How are potential market participants identified for the USDA Farmers Market?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... the USDA Farmers Market? 170.6 Section 170.6 Agriculture Regulations of the Department of Agriculture... AGRICULTURE (CONTINUED) MISCELLANEOUS MARKETING PRACTICES UNDER THE AGRICULTURAL MARKETING ACT OF 1946 USDA FARMERS MARKET § 170.6 How are potential market participants identified for the USDA Farmers Market...

  12. 7 CFR 170.6 - How are potential market participants identified for the USDA Farmers Market?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the USDA Farmers Market? 170.6 Section 170.6 Agriculture Regulations of the Department of Agriculture... AGRICULTURE (CONTINUED) MISCELLANEOUS MARKETING PRACTICES UNDER THE AGRICULTURAL MARKETING ACT OF 1946 USDA FARMERS MARKET § 170.6 How are potential market participants identified for the USDA Farmers Market...

  13. 7 CFR 170.6 - How are potential market participants identified for the USDA Farmers Market?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... the USDA Farmers Market? 170.6 Section 170.6 Agriculture Regulations of the Department of Agriculture... AGRICULTURE (CONTINUED) MISCELLANEOUS MARKETING PRACTICES UNDER THE AGRICULTURAL MARKETING ACT OF 1946 USDA FARMERS MARKET § 170.6 How are potential market participants identified for the USDA Farmers Market...

  14. 7 CFR 170.6 - How are potential market participants identified for the USDA Farmers Market?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... the USDA Farmers Market? 170.6 Section 170.6 Agriculture Regulations of the Department of Agriculture... AGRICULTURE (CONTINUED) MISCELLANEOUS MARKETING PRACTICES UNDER THE AGRICULTURAL MARKETING ACT OF 1946 USDA FARMERS MARKET § 170.6 How are potential market participants identified for the USDA Farmers Market...

  15. Flexible Asymmetric Supercapacitor Based on Functionalized Reduced Graphene Oxide Aerogels with Wide Working Potential Window.

    PubMed

    Bora, Anindita; Mohan, Kiranjyoti; Doley, Simanta; Dolui, Swapan Kumar

    2018-03-07

    Flexible energy storage devices are in great demand since the advent of flexible electronics. Until now, flexible supercapacitors based on graphene analogues usually have had low operating potential windows. To this end, two dissimilar electrode materials with complementary potential ranges are employed to obtain an optimum cell voltage of 1.8 V. A low-temperature organic sol-gel method is used to prepare two different types of functionalized reduced graphene oxide aerogels (rGOA) where Ag nanorod functionalized rGOA acts as a negative electrode while polyaniline nanotube functionalized rGOA acts as a positive electrode. Both materials comprehensively exploit their unique properties to produce a device that has high energy and power densities. An assembled all-solid-state asymmetric supercapacitor gives a high energy density of 52.85 W h kg -1 and power density of 31.5 kW kg -1 with excellent cycling and temperature stability. The device also performs extraordinarily well under different bending conditions, suggesting its potential to meet the requirements for flexible electronics.

  16. 76 FR 63333 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ... and settlement process, potential regulatory changes impacting the Over-The-Counter markets, and Anti-Money laundering concerns specific to microcap issuers. For further information, please contact the...

  17. Improving AIDS Care After Trauma (ImpACT): Pilot Outcomes of a Coping intervention Among HIV-Infected Women with Sexual Trauma in South Africa.

    PubMed

    Sikkema, Kathleen J; Mulawa, Marta I; Robertson, Corne; Watt, Melissa H; Ciya, Nonceba; Stein, Dan J; Cherenack, Emily M; Choi, Karmel W; Kombora, Matapelo; Joska, John A

    2018-03-01

    Improving AIDS Care after Trauma (ImpACT), a coping intervention for HIV-infected women with sexual abuse histories, was evaluated for feasibility and potential efficacy in a public clinic in Cape Town, South Africa. Sixty-four participants were enrolled prior to starting antiretroviral therapy (ART). After completing baseline assessments, participants were randomly assigned to standard of care (SoC: three adherence counseling sessions) or ImpACT (SoC plus four individual and three group sessions). Participants completed assessments at 3 months (after individual sessions) and 6 months post-baseline. In exploratory analysis of primary outcomes, ImpACT participants, compared to SoC, reported greater reductions in avoidance and arousal symptoms of PTSD and greater increases in ART adherence motivation at 3 months. Clinically significant decreases in overall PTSD symptoms were also demonstrated at 3 months. These effects continued as trends at the 6-month assessment, in addition to increases in social/spiritual coping. In analysis of secondary outcomes, high levels of non-adherence to ART and poor care engagement were evident at 6 months, with no differences between study arms. A trauma-focused, culturally-adapted individual intervention delivered by a non-specialist in the HIV care setting is feasible and acceptable. Preliminary findings suggest ImpACT has potential to reduce PTSD symptoms and increase ART adherence motivation, but a more intensive intervention may be needed to improve and maintain care engagement among this population. ClinicalTrials.gov NCT02223390.

  18. Health Care Reform: Understanding Individuals' Attitudes and Information Sources

    PubMed Central

    Shue, Carolyn K.; McGeary, Kerry Anne; Reid, Ian; Fan, Maoyong

    2014-01-01

    Since passage of the Affordable Care Act (ACA) was signed into law by President Barrack Obama, little is known about state-level perceptions of residents on the ACA. Perceptions about the act could potentially affect implementation of the law to the fullest extent. This 3-year survey study explored attitudes about the ACA, the types of information sources that individuals rely on when creating those attitudes, and the predictors of these attitudes among state of Indiana residents. The respondents were split between favorable and unfavorable views of the ACA, yet the majority of respondents strongly supported individual components of the act. National TV news, websites, family members, and individuals' own reading of the ACA legislation were identified as the most influential information sources. After controlling for potential confounders, the respondent's political affiliation, age, sex, and obtaining ACA information from watching national television news were the most important predictors of attitudes about the ACA and its components. These results mirror national-level findings. Implications for implementing health care reform at the state-level are discussed. PMID:25045705

  19. Anaesthetic Tricaine Acts Preferentially on Neural Voltage-Gated Sodium Channels and Fails to Block Directly Evoked Muscle Contraction

    PubMed Central

    Attili, Seetharamaiah; Hughes, Simon M.

    2014-01-01

    Movements in animals arise through concerted action of neurons and skeletal muscle. General anaesthetics prevent movement and cause loss of consciousness by blocking neural function. Anaesthetics of the amino amide-class are thought to act by blockade of voltage-gated sodium channels. In fish, the commonly used anaesthetic tricaine methanesulphonate, also known as 3-aminobenzoic acid ethyl ester, metacaine or MS-222, causes loss of consciousness. However, its role in blocking action potentials in distinct excitable cells is unclear, raising the possibility that tricaine could act as a neuromuscular blocking agent directly causing paralysis. Here we use evoked electrical stimulation to show that tricaine efficiently blocks neural action potentials, but does not prevent directly evoked muscle contraction. Nifedipine-sensitive L-type Cav channels affecting movement are also primarily neural, suggesting that muscle Nav channels are relatively insensitive to tricaine. These findings show that tricaine used at standard concentrations in zebrafish larvae does not paralyse muscle, thereby diminishing concern that a direct action on muscle could mask a lack of general anaesthesia. PMID:25090007

  20. Gender asymmetry

    NASA Astrophysics Data System (ADS)

    2016-05-01

    Investigations of sexual harassment are difficult and potentially destructive to all involved. It is imperative that they are carried out quickly, with high priority and acted upon decisively where misconduct is identified.

  1. Interactions of short-acting, intermediate-acting and pre-mixed human insulins with free radicals--Comparative EPR examination.

    PubMed

    Olczyk, Paweł; Komosinska-Vassev, Katarzyna; Ramos, Paweł; Mencner, Łukasz; Olczyk, Krystyna; Pilawa, Barbara

    2015-07-25

    Electron paramagnetic resonance (EPR) spectroscopy was used to examine insulins interactions with free radicals. Human recombinant DNA insulins of three groups were studied: short-acting insulin (Insuman Rapid); intermediate-acting insulins (Humulin N, Insuman Basal), and pre-mixed insulins (Humulin M3, Gensulin M50, Gensulin M40, Gensulin M30). The aim of an X-band (9.3GHz) study was comparative analysis of antioxidative properties of the three groups of human insulins. DPPH was used as a stable free radical model. Amplitudes of EPR lines of DPPH as the paramagnetic free radical reference, and DPPH interacting with the individual tested insulins were compared. For all the examined insulins kinetics of their interactions with free radicals up to 60 min were obtained. The strongest interactions with free radicals were observed for the short-acting insulin - Insuman Rapid. The lowest interactions with free radicals were characteristic for intermediate-acting insulin - Insuman Basal. The pre-mixed insulins i.e. Humulin M3 and Gensulin M50 revealed the fastest interactions with free radicals. The short acting, intermediate acting and premixed insulins have been found to be effective agents in reducing free radical formation in vitro and should be further considered as potential useful tools in attenuation of oxidative stress in diabetic patients. Copyright © 2015 Elsevier B.V. All rights reserved.

  2. [Acceptance and Commitment Therapy in the Treatment of Chronic Disease].

    PubMed

    Kuba, Katharina; Weißflog, Gregor

    2017-12-01

    Acceptance and Commitment Therapy (ACT) is an intervention representing a transdiagnostic and contextual approach that assumes that psychological suffering is caused by experiential avoidance. The primary intention of ACT is not to eliminate symptoms and to treat mental disorders. Instead, ACT aims to increase psychological flexibility, i. e. to broaden the repertoire of cognitions and behaviors when facing inner and outer aversive events or experiences. Psychological flexibility can be enhanced by working with the 6 core components of the ACT model. Experience-focused methods like metaphors and exercises for acceptance play a crucial role in the therapeutic work. In short, with ACT patients can learn: ▪ that rigid and inflexible attempts to fight aversive experience are problematic ▪ a mindful experience of inner and outer experience ▪ to differentiate between unchangeable and changeable events (acceptance) ▪ to identify values or respectively life goals and to behave in a way that is consistent with them (commitment)The therapeutic focus of ACT is to create a balance between acceptance and behavioral change consistent with chosen values. Chronic diseases are often associated with aversive inner and outer experiences. A growing number of studies support the efficacy of ACT. There is evidence that ACT can increase psychological flexibility and potentially also lead to better self-management within the context of chronic somatic diseases. © Georg Thieme Verlag KG Stuttgart · New York.

  3. Positive pressure--analysing the effect of the addition of non-invasive ventilation (NIV) to home airway clearance techniques (ACT) in adult cystic fibrosis (CF) patients.

    PubMed

    Stanford, Gemma; Parrott, Helen; Bilton, Diana; Agent, Penny

    2015-05-01

    There is no published literature on the frequency of use of non-invasive ventilation (NIV) with airway clearance techniques (ACT) throughout the cystic fibrosis (CF) population; 3.9% (191 people of 5062 registered) of the United Kingdom CF population older than 16 years are reported to use NIV in registry data; however, it is not specified if this is for ACT or respiratory failure. Using NIV with ACT decreases work of breathing and fatigue during in-patient admissions for CF patients. We hypothesised these effects could be replicated at home, potentially reducing hospital admissions. Fourteen adult patients with CF scored ease of clearance and breathlessness with ACT before and after addition of NIV to normal ACT routine using a visual analog scale. Patient views on NIV with ACT were collected via a structured interview. Number of home intravenous (IV) antibiotic courses and days in hospital was collected for one year pre- and post-NIV provision. Patients reported statistically significant improvements in ease of clearance (p = 0.011) and reduced breathlessness during ACT using NIV (p = 0.011). Structured interview results indicated patient reports of sputum clearance improved. In-patient days were lower, while home IV days were higher after NIV was set up, although not statistically significant. This study is limited by small numbers; however, trends towards less hospital admissions and greater patient ease while using NIV with ACT warrant further investigation.

  4. Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine

    PubMed Central

    Yu, Qian-sheng; Holloway, Harold W.; Luo, Weiming; Lahiri, Debomoy K.; Brossi, Arnold; Greig, Nigel H.

    2010-01-01

    The N-monophenylcarbamate analogues of neostigmine methyl sulfate (6) and pyridostigmine bromide (8) together with their precursors (5), (7), and the N(1)-methylammonium analogues of (−)-phenserine (12), (−)-tolserine (14), (−)-cymserine (16) and (−)-phenethylcymserine (18) were synthesized to produce long-acting peripheral inhibitors of acetylcholinesterase or butyrylcholinesterase. Evaluation of their cholinesterase inhibition against human enzyme ex vivo demonstrated that, whereas compounds 5–8 possessed only marginal activity, 12, 14, 16 and 18 proved to be potent anticholinesterases. An extended duration of cholinesterase inhibition was determined in rodent, making them of potential interest as long-acting agents for myasthenia gravis. PMID:20627738

  5. Aripiprazole Long-Acting Injectable for Maintenance Treatment of Bipolar I Disorder in Adults.

    PubMed

    Aggarwal, Arpit; Schrimpf, Lindsey; Lauriello, John

    2018-01-01

    Bipolar I disorder is a serious and disabling psychiatric illness. It is associated with a significant reduction in quality of life and an increased risk for suicide. Pharmacotherapy is essential for both the acute and maintenance treatment of bi-polar I disorder. While multiple oral medications are recommended for the maintenance treatment, there are not many long-acting injectable medications approved for this indication. New treatments that would improve patient adherence have the potential for decreasing relapses and improving patients' ability to remain functional members of society. In this paper we discuss the available data for safety and efficacy of aripiprazole long-acting injectable in bipolar disorder.

  6. Avoiding Title V permitting pitfalls

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Laswell, D.L.

    1993-04-01

    Title V of the 1990 Clean Air Act Amendments requires states to implement new air operating permit programs. States have a great deal of flexibility in developing their permit programs. Industry should work now to ensure that state programs contain the favorable aspects of the federal regulations and do not contain more stringent requirements that are not required under the Clean Air Act. This article outlines areas of the permit program that have the potential to handicap industry`s ability to expand.

  7. Navy-New Hampshire Wind Energy Program.

    DTIC Science & Technology

    1979-11-01

    Hampshire 156 3.2.2.6.4 Legal/Institutional Barriers 157 3.2.2.6.4.1 Public Utilities Regulatory Policy Act ( PURPA ) 157 3.2.2.6.4.2 State of New...Regulatory Policy Act ( PURPA ) The greatest potential barrier to the introduction of wind turbine machines for the generation of electronic power is the...from qualified cogenerators at just and reasonable rates. Two of the provisions of PURPA are especially relc ant to the introduction of wind turbine

  8. Higher Education and Disability: Education Needs a Coordinated Approach to Improve Its Assistance to Schools in Supporting Students. Report to the Chairman, Committee on Education and Labor, House of Representatives. GAO-10-33

    ERIC Educational Resources Information Center

    US Government Accountability Office, 2009

    2009-01-01

    Research suggests that more students with disabilities are pursuing higher education than in years past, and recent legislative changes, such as those in the Higher Education Opportunity Act and Post-9/11 Veterans Educational Assistance Act of 2008, have the potential to increase the number and diversity of this population. GAO was asked to…

  9. PORTNUS Project

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Loyal, Rebecca E.

    The objective of the Portunus Project is to create large, automated offshore ports that will the pace and scale of international trade. Additionally, these ports would increase the number of U.S. domestic trade vessels needed, as the imported goods would need to be transported from these offshore platforms to land-based ports such as Boston, Los Angeles, and Newark. Currently, domestic trade in the United States can only be conducted by vessels that abide by the Merchant Marine Act of 1920 – also referred to as the Jones Act. The Jones Act stipulates that vessels involved in domestic trade must bemore » U.S. owned, U.S. built, and manned by a crew made up of U.S. citizens. The Portunus Project would increase the number of Jones Act vessels needed, which raises an interesting economic concern. Are Jones Act ships more expensive to operate than foreign vessels? Would it be more economically efficient to modify the Jones Act and allow vessels manned by foreign crews to engage in U.S. domestic trade? While opposition to altering the Jones Act is strong, it is important to consider the possibility that ship-owners who employ foreign crews will lobby for the chance to enter a growing domestic trade market. Their success would mean potential job loss for thousands of Americans currently employed in maritime trade.« less

  10. 78 FR 2077 - Implementation of the Local Community Radio Act of 2010; Revision of Service and Eligibility...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-09

    ... strictly defined circumstances.'' In contrast, Prometheus and others argue that ``[b]eyond a showing of non... the potential benefit of promoting a locally-based non-commercial radio service in potentially... stations as operating with non-directional antennas at their authorized power. 13. We turn now to what...

  11. Caregiver Mental Health and Potentially Harmful Caregiving Behavior: The Central Role of Caregiver Anger

    ERIC Educational Resources Information Center

    MacNeil, Gordon; Kosberg, Jordan I.; Durkin, Daniel W.; Dooley, W. Keith; DeCoster, Jamie; Williamson, Gail M.

    2010-01-01

    Purpose: Caregivers feeling stress and experiencing mental health problems can be at risk for engaging in abusive acts against elderly care recipients. Potentially harmful behavior (PHB) was used as a measure of caregivers' engagement in, or fear of engagement in, behavior that places dependent care recipients at risk of physical and/or…

  12. Viewing Objects and Planning Actions: On the Potentiation of Grasping Behaviours by Visual Objects

    ERIC Educational Resources Information Center

    Makris, Stergios; Hadar, Aviad A.; Yarrow, Kielan

    2011-01-01

    How do humans interact with tools? Gibson (1979) suggested that humans perceive directly what tools afford in terms of meaningful actions. This "affordances" hypothesis implies that visual objects can potentiate motor responses even in the absence of an intention to act. Here we explore the temporal evolution of motor plans afforded by common…

  13. 75 FR 32952 - Draft Guidance for Industry and Food and Drug Administration Staff; “‘Harmful and Potentially...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-10

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2010-D-0281] Draft Guidance for Industry and Food and Drug Administration Staff; ```Harmful and Potentially Harmful... Food, Drug, and Cosmetic Act.'' This draft guidance provides written guidance to industry and FDA staff...

  14. The cost effectiveness of long-acting/extended-release antipsychotics for the treatment of schizophrenia: a systematic review of economic evaluations.

    PubMed

    Achilla, Evanthia; McCrone, Paul

    2013-04-01

    Antipsychotic medication is the mainstay of treatment in schizophrenia. Long-acting medication has potential advantages over daily medication in improving compliance and thus reducing hospitalization and relapse rates. The high acquisition and administration costs of such formulations raise the need for pharmacoeconomic evaluation. The aim of this article is to provide a comprehensive review of the available evidence on the cost effectiveness of long-acting/extended-release antipsychotic medication and critically appraise the strength of evidence reported in the studies from a methodological viewpoint. Relevant studies were identified by searching five electronic databases: PsycINFO, MEDLINE, EMBASE, the NHS Economic Evaluation Database and the Health Technology Assessment database (HTA). Search terms included, but were not limited to, 'long-acting injection', 'economic evaluation', 'cost-effectiveness' and 'cost-utility'. No limits were applied for publication dates and language. Full economic evaluations on long-acting/extended-release antipsychotics were eligible for inclusion. Observational studies and clinical trials were also checked for cost-effectiveness information. Conference abstracts and poster presentations on the cost effectiveness of long-acting antipsychotics were excluded. Thirty-two percent of identified studies met the selection criteria. Pertinent abstracts were reviewed independently by two reviewers. Relevant studies underwent data extraction by one reviewer and were checked by a second, with any discrepancies being clarified during consensus meetings. Eligible studies were assessed for methodological quality using the quality checklist for economic studies recommended by the NICE guideline on interventions in the treatment and management of schizophrenia. After applying the selection criteria, the final sample consisted of 28 studies. The majority of studies demonstrated that risperidone long-acting injection, relative to oral or other long-acting injectable drugs, was associated with cost savings and additional clinical benefits and was the dominant strategy in terms of cost effectiveness. However, olanzapine in either oral or long-acting injectable formulation dominated risperidone long-acting injection in a Slovenian and a US study. Furthermore, in two UK studies, the use of long-acting risperidone increased the hospitalization days and overall healthcare costs, relative to other atypical or typical long-acting antipsychotics. Finally, paliperidone extended-release was the most cost-effective treatment compared with atypical oral or typical long-acting formulations. From a methodological viewpoint, most studies employed decision analytic models, presented results using average cost-effectiveness ratios and conducted comprehensive sensitivity analyses to test the robustness of the results. Variations in study methodologies restrict consistent and direct comparisons across countries. The exclusion of a large body of potentially relevant conference abstracts as well as some papers being unobtainable may have increased the likelihood of misrepresenting the overall cost effectiveness of long-acting antipsychotics. Finally, the review process was restricted to qualitative assessment rather than a quantitative synthesis of results, which could provide more robust conclusions. Atypical long-acting (especially risperidone)/extended-release antipsychotic medication is likely to be a cost-effective, first-line strategy for managing schizophrenia, compared with long-acting haloperidol and other oral or depot formulations, irrespective of country-specific differences. However, inconsistencies in study methodologies and in the reporting of study findings suggest caution needs to be applied in interpreting these findings.

  15. 7 CFR 3565.255 - Environmental requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... requirements. Under the National Environmental Policy Act, the Agency is required to assess the potential impact of the proposed actions on protected environmental resources. Measures to avoid or at least...

  16. Synthesis and pharmacological characterization of novel inverse agonists acting on the viral-encoded chemokine receptor US28.

    PubMed

    Hulshof, Janneke W; Vischer, Henry F; Verheij, Mark H P; Fratantoni, Silvina A; Smit, Martine J; de Esch, Iwan J P; Leurs, Rob

    2006-11-01

    G-protein coupled receptors encoded by viruses represent an unexplored class of potential drug targets. In this study, we describe the synthesis and pharmacological characterization of the first class of inverse agonists acting on the HCMV-encoded receptor US28. It is shown that replacement of the 4-hydroxy group of lead compound 1 with a methylamine group results in a significant 6-fold increase in affinity. Interestingly, increasing the rigidity of the spacer by the introduction of a double bond also leads to a significant increase in binding affinity compared to 1. These novel inverse agonists serve as valuable tools to elucidate the role of constitutive signaling in the pathogenesis of viral infection and may have therapeutic potential as leads for new antiviral drugs.

  17. Developing a Legal Framework for Advance Healthcare Planning: Comparing England & Wales and Ireland.

    PubMed

    Donnelly, Mary

    2017-03-01

    This article examines the legislative frameworks for advance healthcare planning in England & Wales (the Mental Capacity Act 2005) and in Ireland (the Assisted Decision-Making (Capacity) Act 2015), undertaking a comparative analysis of each measure, with particular focus on the detail of the approaches taken. It is only through this kind of detailed focus that the normative choices made by legislation can fully be understood and evaluated. The article argues that, in several respects, possibly because the drafters were able to reflect lessons learned from other jurisdictions, the Assisted Decision-Making (Capacity) Act 2015 provides a more rounded and complete form of advance healthcare planning than that provided by the Mental Capacity Act. This is on the basis that it provides more protection for patient choice; better potential for delivery on the choices made; and a more appropriate balance between formalities and enforceability.

  18. Soluble activin receptor type IIB decoy receptor differentially impacts murine osteogenesis imperfecta muscle function.

    PubMed

    Jeong, Youngjae; Daghlas, Salah A; Kahveci, Alp S; Salamango, Daniel; Gentry, Bettina A; Brown, Marybeth; Rector, R Scott; Pearsall, R Scott; Phillips, Charlotte L

    2018-02-01

    Osteogenesis imperfecta (OI) is characterized by skeletal fragility and muscle weakness. In this study we investigated the effects of soluble activin type IIB receptor (sActRIIB-mFc) on muscle mass and function in 2 distinct mouse models of OI: osteogenesis imperfecta murine (oim) and +/G610C. Wild-type (WT), +/G610C, and oim/oim mice were treated from 2 to 4 months of age with Tris-buffered saline (vehicle) or sActRIIB-mFc and their hindlimb muscles evaluated for mass, morphology, and contractile function. sActRIIB-mFc-treated WT, +/G610C, and oim/oim mice had increased hindlimb muscle weights and myofiber cross-sectional area compared with vehicle-treated counterparts. sActRIIB-mFc-treated oim/oim mice also exhibited increased contractile function relative to vehicle-treated counterparts. Blocking endogenous ActRIIB was effective at increasing muscle size in mouse models of OI, and increasing contractile function in oim/oim mice. ActRIIB inhibitors may provide a potential mutation-specific therapeutic option for compromised muscle function in OI. Muscle Nerve 57: 294-304, 2018. © 2017 Wiley Periodicals, Inc.

  19. Where there is a goal, there is a way: what, why and how the parieto-frontal mirror network can mediate imitative behaviours.

    PubMed

    Casartelli, Luca; Molteni, Massimo

    2014-11-01

    The relationships between mirror neurons (MNs) and motor imitation, and its clinical implications in autism spectrum disorder (ASD) have been widely investigated; however, the literature remains—at least partially—controversial. In this review we support a multi-level action understanding model focusing on the mirror-based understanding. We review the functional role of the parieto-frontal MNs (PFMN) network claiming that PFMNs function cannot be limited to imitation nor can imitation be explained solely by the activity of PFMNs. The distinction between movement, motor act and motor action is useful to characterize deeply both act(ion) understanding and imitation of act(ion). A more abstract representation of act(ion) may be crucial for clarifying what, why and how an imitator is imitating. What counts in social interactions is achieving goals: it does not matter which effector or string of motor acts you eventually use for achieving (proximal and distal) goals. Similarly, what counts is the ability to recognize/imitate the style of act(ion) regardless of the way in which it is expressed. We address this crucial point referring to its potential implications in ASD. Copyright © 2014 Elsevier Ltd. All rights reserved.

  20. Water Infrastructure Finance and Innovation Act

    EPA Pesticide Factsheets

    How WIFIA works, program implementation, program guidance, how potential recipients can obtain funding, and project eligibility. WIFIA works with State Revolving Funds to provide subsidized financing for large dollar-value projects.

  1. Family Maltreatment, Substance Problems, and Suicidality: Prevalence Surveillance and Ecological Risk/Protective Factor Models

    DTIC Science & Technology

    2011-04-01

    participating parents were offered the opportunity to report reason(s) for their behavior. That is, for each potential act (e.g., “I spanked the child on...whether (and why) they had engaged in each of seven relatively mild discipline behaviors (e.g., spanked child on the bottom with a bare hand...Most parents with low non-zero variety scores reported engaging in only mild acts like spanking and slapping, whereas parents who reported relatively

  2. Hearing on the Reauthorization of the Higher Education Act of 1965; Sallie Mae--Safety and Soundness. Hearing before the Subcommittee on Postsecondary Education of the Committee on Education and Labor. House of Representatives, One Hundred Second Congress, First Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Subcommittee on Postsecondary Education.

    As part of a series of hearings on the reauthorization of the Higher Education Act of 1965, testimony was heard on the safety and soundness of the Student Loan Marketing Association (Sallie Mae). Witnesses discussed many issues surrounding financial oversight of federal agencies and financial risk to the taxpayer through the potential failure of…

  3. A Psychodynamic Systems Perspective on Command Relationship during Combat Operations

    DTIC Science & Technology

    2017-06-09

    that theirs is a high likelihood of conflicts when leaders fail to act as a boundary regulator. Failing to act as a boundary regulator, affects the...healthy command climate based on mission command.2 However, leaders do not always succeed in this task, and when they fail it, can have severe... when a leader fails to fulfill his role as a boundary regulator, there is a marked potential for conflict, as was highlighted with the case where the

  4. Job Corps Amendments of 1984. Hearing before the Committee on Labor and Human Resources, United States Senate, Ninety-Eighth Congress, Second Session on S. 2111, to Amend Part B of Title IV of the Job Training Partnership Act, to Strengthen the Job Corps Program.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Committee on Labor and Human Resources.

    This Congressional report contains testimony pertaining to amending the Job Training Partnership Act (JTPA) to strengthen the Job Corps Program. The primary focus of the hearing was on the current adequacy and future potential of the Job Corps' vocational and basic education programs, facilities and equipment, residential living and enrichment…

  5. NASA's Principal Center for Review of Clean Air Act Regulations

    NASA Technical Reports Server (NTRS)

    Clark-Ingram, Marceia

    2003-01-01

    Marshall Space Flight Center (MSFC) was selected as the Principal Center for review of Clean Air Act (CAA) regulations. The CAA Principal Center is tasked to: 1) Provide centralized support to NASA/HDQ Code JE for the management and leadership of NASA's CAA regulation review process; 2) Identify potential impact from proposed CAA regulations to NASA program hardware and supporting facilities. The Shuttle Environmental Assurance Initiative, one of the responsibilities of the NASA CAA Working Group (WG), is described in part of this viewgraph presentation.

  6. Molecular Detection, Quantification, and Toxigenicity Profiling of Aeromonas spp. in Source- and Drinking-Water

    PubMed Central

    Robertson, Boakai K; Harden, Carol; Selvaraju, Suresh B; Pradhan, Suman; Yadav, Jagjit S

    2014-01-01

    Aeromonas is ubiquitous in aquatic environments and has been associated with a number of extra-gastrointestinal and gastrointestinal illnesses. This warrants monitoring of raw and processed water sources for pathogenic and toxigenic species of this human pathogen. In this study, a total of 17 different water samples [9 raw and 8 treated samples including 4 basin water (partial sand filtration) and 4 finished water samples] were screened for Aeromonas using selective culturing and a genus-specific real-time quantitative PCR assay. The selective culturing yielded Aeromonas counts ranging 0 – 2 x 103CFU/ml and 15 Aeromonas isolates from both raw and treated water samples. The qPCR analysis indicated presence of a considerable nonculturable population (3.4 x 101 – 2.4 x 104 cells/ml) of Aeromonas in drinking water samples. Virulence potential of the Aeromonas isolates was assessed by multiplex/singleplex PCR-based profiling of the hemolysin and enterotoxin genes viz cytotoxic heat-labile enterotoxin (act), heat-labile cytotonic enterotoxin (alt), heat-stable cytotonic enterotoxin (ast), and aerolysin (aerA) genes. The water isolates yielded five distinct toxigenicity profiles, viz. act, alt, act+alt, aerA+alt, and aerA+alt+act. The alt gene showed the highest frequency of occurrence (40%), followed by the aerA (20%), act (13%), and ast (0%) genes. Taken together, the study demonstrated the occurrence of a considerable population of nonculturable Aeromonads in water and prevalence of toxigenic Aeromonas spp. potentially pathogenic to humans. This emphasizes the importance of routine monitoring of both source and drinking water for this human pathogen and role of the developed molecular approaches in improving the Aeromonas monitoring scheme for water. PMID:24949108

  7. Development and assessment of the Alberta Context Tool.

    PubMed

    Estabrooks, Carole A; Squires, Janet E; Cummings, Greta G; Birdsell, Judy M; Norton, Peter G

    2009-12-15

    The context of healthcare organizations such as hospitals is increasingly accepted as having the potential to influence the use of new knowledge. However, the mechanisms by which the organizational context influences evidence-based practices are not well understood. Current measures of organizational context lack a theory-informed approach, lack construct clarity and generally have modest psychometric properties. This paper presents the development and initial psychometric validation of the Alberta Context Tool (ACT), an eight dimension measure of organizational context for healthcare settings. Three principles guided the development of the ACT: substantive theory, brevity, and modifiability. The Promoting Action on Research Implementation in Health Services (PARiHS) framework and related literature were used to guide selection of items in the ACT. The ACT was required to be brief enough to be tolerated in busy and resource stretched work settings and to assess concepts of organizational context that were potentially modifiable. The English version of the ACT was completed by 764 nurses (752 valid responses) working in seven Canadian pediatric care hospitals as part of its initial validation. Cronbach's alpha, exploratory factor analysis, analysis of variance, and tests of association were used to assess instrument reliability and validity. Factor analysis indicated a 13-factor solution (accounting for 59.26% of the variance in 'organizational context'). The composition of the factors was similar to those originally conceptualized. Cronbach's alpha for the 13 factors ranged from .54 to .91 with 4 factors performing below the commonly accepted alpha cut off of .70. Bivariate associations between instrumental research utilization levels (which the ACT was developed to predict) and the ACT's 13 factors were statistically significant at the 5% level for 12 of the 13 factors. Each factor also showed a trend of increasing mean score ranging from the lowest level to the highest level of instrumental research use, indicating construct validity. To date, no completely satisfactory measures of organizational context are available for use in healthcare. The ACT assesses several core domains to provide a comprehensive account of organizational context in healthcare settings. The tool's strengths are its brevity (allowing it to be completed in busy healthcare settings) and its focus on dimensions of organizational context that are modifiable. Refinements of the instrument for acute, long term care, and home care settings are ongoing.

  8. Development and assessment of the Alberta Context Tool

    PubMed Central

    2009-01-01

    Background The context of healthcare organizations such as hospitals is increasingly accepted as having the potential to influence the use of new knowledge. However, the mechanisms by which the organizational context influences evidence-based practices are not well understood. Current measures of organizational context lack a theory-informed approach, lack construct clarity and generally have modest psychometric properties. This paper presents the development and initial psychometric validation of the Alberta Context Tool (ACT), an eight dimension measure of organizational context for healthcare settings. Methods Three principles guided the development of the ACT: substantive theory, brevity, and modifiability. The Promoting Action on Research Implementation in Health Services (PARiHS) framework and related literature were used to guide selection of items in the ACT. The ACT was required to be brief enough to be tolerated in busy and resource stretched work settings and to assess concepts of organizational context that were potentially modifiable. The English version of the ACT was completed by 764 nurses (752 valid responses) working in seven Canadian pediatric care hospitals as part of its initial validation. Cronbach's alpha, exploratory factor analysis, analysis of variance, and tests of association were used to assess instrument reliability and validity. Results Factor analysis indicated a 13-factor solution (accounting for 59.26% of the variance in 'organizational context'). The composition of the factors was similar to those originally conceptualized. Cronbach's alpha for the 13 factors ranged from .54 to .91 with 4 factors performing below the commonly accepted alpha cut off of .70. Bivariate associations between instrumental research utilization levels (which the ACT was developed to predict) and the ACT's 13 factors were statistically significant at the 5% level for 12 of the 13 factors. Each factor also showed a trend of increasing mean score ranging from the lowest level to the highest level of instrumental research use, indicating construct validity. Conclusions To date, no completely satisfactory measures of organizational context are available for use in healthcare. The ACT assesses several core domains to provide a comprehensive account of organizational context in healthcare settings. The tool's strengths are its brevity (allowing it to be completed in busy healthcare settings) and its focus on dimensions of organizational context that are modifiable. Refinements of the instrument for acute, long term care, and home care settings are ongoing. PMID:20003531

  9. On the v-representability of ensemble densities of electron systems

    NASA Astrophysics Data System (ADS)

    Gonis, A.; Däne, M.

    2018-05-01

    Analogously to the case at zero temperature, where the density of the ground state of an interacting many-particle system determines uniquely (within an arbitrary additive constant) the external potential acting on the system, the thermal average of the density over an ensemble defined by the Boltzmann distribution at the minimum of the thermodynamic potential, or the free energy, determines the external potential uniquely (and not just modulo a constant) acting on a system described by this thermodynamic potential or free energy. The paper describes a formal procedure that generates the domain of a constrained search over general ensembles (at zero or elevated temperatures) that lead to a given density, including as a special case a density thermally averaged at a given temperature, and in the case of a v-representable density determines the external potential leading to the ensemble density. As an immediate consequence of the general formalism, the concept of v-representability is extended beyond the hitherto discussed case of ground state densities to encompass excited states as well. Specific application to thermally averaged densities solves the v-representability problem in connection with the Mermin functional in a manner analogous to that in which this problem was recently settled with respect to the Hohenberg and Kohn functional. The main formalism is illustrated with numerical results for ensembles of one-dimensional, non-interacting systems of particles under a harmonic potential.

  10. On the v-representability of ensemble densities of electron systems

    DOE PAGES

    Gonis, A.; Dane, M.

    2017-12-30

    Analogously to the case at zero temperature, where the density of the ground state of an interacting many-particle system determines uniquely (within an arbitrary additive constant) the external potential acting on the system, the thermal average of the density over an ensemble defined by the Boltzmann distribution at the minimum of the thermodynamic potential, or the free energy, determines the external potential uniquely (and not just modulo a constant) acting on a system described by this thermodynamic potential or free energy. The study describes a formal procedure that generates the domain of a constrained search over general ensembles (at zeromore » or elevated temperatures) that lead to a given density, including as a special case a density thermally averaged at a given temperature, and in the case of a v-representable density determines the external potential leading to the ensemble density. As an immediate consequence of the general formalism, the concept of v-representability is extended beyond the hitherto discussed case of ground state densities to encompass excited states as well. Specific application to thermally averaged densities solves the v-representability problem in connection with the Mermin functional in a manner analogous to that in which this problem was recently settled with respect to the Hohenberg and Kohn functional. Finally, the main formalism is illustrated with numerical results for ensembles of one-dimensional, non-interacting systems of particles under a harmonic potential.« less

  11. Climate Change Workgroup Reports and Presentations

    EPA Pesticide Factsheets

    Climate Change Workgroup reports and presentations to discuss and identify the major issues and potential barriers to implementing the Prevention of Significant Deterioration program under the Clean Air Act for greenhouse gases.

  12. 17 CFR 39.2 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... provision of clearing and settlement services, risk management, or oversight of compliance with the Act and... planning or program execution. Stress test means a test that compares the impact of potential extreme price...

  13. 17 CFR 39.2 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... provision of clearing and settlement services, risk management, or oversight of compliance with the Act and... planning or program execution. Stress test means a test that compares the impact of potential extreme price...

  14. Trial Watch

    PubMed Central

    Aranda, Fernando; Vacchelli, Erika; Obrist, Florine; Eggermont, Alexander; Galon, Jérôme; Hervé Fridman, Wolf; Cremer, Isabelle; Tartour, Eric; Zitvogel, Laurence; Kroemer, Guido; Galluzzi, Lorenzo

    2014-01-01

    The expression “adoptive cell transfer” (ACT) is commonly employed to indicate an immunotherapeutic regimen involving the isolation of autologous blood-borne or tumor-infiltrating lymphocytes, their selection/expansion/activation ex vivo, and their reinfusion into the patient, most often in the context of lymphodepleting pre-conditioning and in combination with immunostimulatory treatments. Optionally, the cellular material for ACT is genetically manipulated before expansion to (1) target specific tumor-associated antigens; (2) endogenously express immunostimulatory molecules; and/or (3) persist for long periods upon reinfusion. Consistent efforts have been dedicated at the amelioration of this immunotherapeutic regimen throughout the past decade, resulting in the establishment of ever more efficient and safer ACT protocols. Accordingly, the number of clinical trials testing ACT in oncological indications does not cease to increase. In this Trial Watch, we summarize recent developments in this exciting area of research, covering both high-impact studies that have been published during the last 12 months and clinical trials that have been launched in the same period to evaluate the safety and therapeutic potential of ACT in cancer patients. PMID:25050207

  15. Trial Watch: Adoptive cell transfer for oncological indications

    PubMed Central

    Aranda, Fernando; Buqué, Aitziber; Bloy, Norma; Castoldi, Francesca; Eggermont, Alexander; Cremer, Isabelle; Fridman, Wolf Hervé; Fucikova, Jitka; Galon, Jérôme; Spisek, Radek; Tartour, Eric; Zitvogel, Laurence; Kroemer, Guido; Galluzzi, Lorenzo

    2015-01-01

    One particular paradigm of anticancer immunotherapy relies on the administration of (potentially) tumor-reactive immune effector cells. Generally, these cells are obtained from autologous peripheral blood lymphocytes (PBLs) ex vivo (in the context of appropriate expansion, activation and targeting protocols), and re-infused into lymphodepleted patients along with immunostimulatory agents. In spite of the consistent progress achieved throughout the past two decades in this field, no adoptive cell transfer (ACT)-based immunotherapeutic regimen is currently approved by regulatory agencies for use in cancer patients. Nonetheless, the interest of oncologists in ACT-based immunotherapy continues to increase. Accumulating clinical evidence indicates indeed that specific paradigms of ACT, such as the infusion of chimeric antigen receptor (CAR)-expressing autologous T cells, are associated with elevated rates of durable responses in patients affected by various neoplasms. In line with this notion, clinical trials investigating the safety and therapeutic activity of ACT in cancer patients are being initiated at an ever increasing pace. Here, we review recent preclinical and clinical advances in the development of ACT-based immunotherapy for oncological indications. PMID:26451319

  16. Trial Watch: Adoptive cell transfer for oncological indications.

    PubMed

    Aranda, Fernando; Buqué, Aitziber; Bloy, Norma; Castoldi, Francesca; Eggermont, Alexander; Cremer, Isabelle; Fridman, Wolf Hervé; Fucikova, Jitka; Galon, Jérôme; Spisek, Radek; Tartour, Eric; Zitvogel, Laurence; Kroemer, Guido; Galluzzi, Lorenzo

    2015-11-01

    One particular paradigm of anticancer immunotherapy relies on the administration of (potentially) tumor-reactive immune effector cells. Generally, these cells are obtained from autologous peripheral blood lymphocytes (PBLs) ex vivo (in the context of appropriate expansion, activation and targeting protocols), and re-infused into lymphodepleted patients along with immunostimulatory agents. In spite of the consistent progress achieved throughout the past two decades in this field, no adoptive cell transfer (ACT)-based immunotherapeutic regimen is currently approved by regulatory agencies for use in cancer patients. Nonetheless, the interest of oncologists in ACT-based immunotherapy continues to increase. Accumulating clinical evidence indicates indeed that specific paradigms of ACT, such as the infusion of chimeric antigen receptor (CAR)-expressing autologous T cells, are associated with elevated rates of durable responses in patients affected by various neoplasms. In line with this notion, clinical trials investigating the safety and therapeutic activity of ACT in cancer patients are being initiated at an ever increasing pace. Here, we review recent preclinical and clinical advances in the development of ACT-based immunotherapy for oncological indications.

  17. Trial Watch: Adoptive cell transfer for anticancer immunotherapy.

    PubMed

    Aranda, Fernando; Vacchelli, Erika; Obrist, Florine; Eggermont, Alexander; Galon, Jérôme; Hervé Fridman, Wolf; Cremer, Isabelle; Tartour, Eric; Zitvogel, Laurence; Kroemer, Guido; Galluzzi, Lorenzo

    2014-01-01

    The expression "adoptive cell transfer" (ACT) is commonly employed to indicate an immunotherapeutic regimen involving the isolation of autologous blood-borne or tumor-infiltrating lymphocytes, their selection/expansion/activation ex vivo, and their reinfusion into the patient, most often in the context of lymphodepleting pre-conditioning and in combination with immunostimulatory treatments. Optionally, the cellular material for ACT is genetically manipulated before expansion to (1) target specific tumor-associated antigens; (2) endogenously express immunostimulatory molecules; and/or (3) persist for long periods upon reinfusion. Consistent efforts have been dedicated at the amelioration of this immunotherapeutic regimen throughout the past decade, resulting in the establishment of ever more efficient and safer ACT protocols. Accordingly, the number of clinical trials testing ACT in oncological indications does not cease to increase. In this Trial Watch, we summarize recent developments in this exciting area of research, covering both high-impact studies that have been published during the last 12 months and clinical trials that have been launched in the same period to evaluate the safety and therapeutic potential of ACT in cancer patients.

  18. The unsteady state and inertia of chemical regulation under the US Toxic Substances Control Act.

    PubMed

    Krimsky, Sheldon

    2017-12-01

    After 40 years, the 1976 US Toxic Substances Control Act (TSCA) was revised under the Frank R. Lautenberg Chemical Safety for the 21st Century Act. Its original goals of protecting the public from hazardous chemicals were hindered by complex and cumbersome administrative burdens, data limitations, vulnerabilities in risk assessments, and recurring corporate lawsuits. As a result, countless chemicals were entered into commercial use without toxicological information. Few chemicals of the many identified as potential public health threats were regulated or banned. This paper explores the factors that have worked against a comprehensive and rational policy for regulating toxic chemicals and discusses whether the TSCA revisions offer greater public protection against existing and new chemicals.

  19. The unsteady state and inertia of chemical regulation under the US Toxic Substances Control Act

    PubMed Central

    2017-01-01

    After 40 years, the 1976 US Toxic Substances Control Act (TSCA) was revised under the Frank R. Lautenberg Chemical Safety for the 21st Century Act. Its original goals of protecting the public from hazardous chemicals were hindered by complex and cumbersome administrative burdens, data limitations, vulnerabilities in risk assessments, and recurring corporate lawsuits. As a result, countless chemicals were entered into commercial use without toxicological information. Few chemicals of the many identified as potential public health threats were regulated or banned. This paper explores the factors that have worked against a comprehensive and rational policy for regulating toxic chemicals and discusses whether the TSCA revisions offer greater public protection against existing and new chemicals. PMID:29252997

  20. Genetic discrimination and the employment provisions of the Americans with Disabilities Act: emerging legal, empirical, and policy implications.

    PubMed

    Blanck, P D; Marti, M W

    1996-01-01

    The Americans with Disabilities Act of 1990 (ADA) is the most comprehensive federal civil rights law addressing employment discrimination against potentially millions of Americans. The Human Genome Project (HGP) is a federally funded research effort that seeks to map and sequence every human gene. This article is meant to contribute to the emerging dialogue on the interplay between the HGP and the employment provisions of the ADA, set forth in the Title I of the act. The relevance of the HGP to emerging legal questions, including those arising under Title I and recent EEOC guidelines, is described. Thereafter, empirical issues are discussed, and directions for future investigation of genetic discrimination under the ADA are explored.

  1. Broadcast Satellites; Their Potential Use for Educational Purposes, and Their Relationship to International Understanding and Cooperation. Occasional Paper Number Three.

    ERIC Educational Resources Information Center

    Hanessian, John, Jr.; Margolin, Joseph B.

    Although the United Nations, through its Working Group on Direct Broadcast Satellites, and the United States, through its Communications Satellite Act of 1962, have directed attention to satellite communication systems, a gulf exists between the available technology and the educational planners concerned with the potential use of such systems.…

  2. Draft environmental assessment: Lavender Canyon site, Utah. Nuclear Waste Policy Act (Section 112). [Contains glossary

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1984-12-01

    In February 1983, the US Department of Energy (DOE) identified the Lavender Canyon site in Utah, as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Lavender Canyon site and the eight other potentially acceptable sites h

  3. Confirmation of Echinococcus canadensis G8 and G10 in Idaho Gray Wolves ( Canis lupus) and Cervids.

    PubMed

    Cerda, Jacey Roche; Ballweber, Lora Rickard

    2018-04-01

    We confirm the presence of Echinococcus canadensis genotypes G8 and G10 in gray wolves ( Canis lupus) and cervids in Idaho, US. Our results demonstrated that cystic echinococcosis remains a potential public health issue, indicating the need for regular deworming of domestic dogs, who often act as potential bridge hosts.

  4. TERRORIST PROTECTION PLANNING USING A RELATIVE RISK REDUCTION APPROACH, SESSION VIII: TECHNOLOGY FORUM FOCUS GROUPS.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    INDUSI,J.P.

    2003-06-16

    Since the events of 9/11, there have been considerable concerns and associated efforts to prevent or respond to acts of terrorism. Very often we hear calls to reduce the threat from or correct vulnerabilities to various terrorist acts. Others fall victim to anxiety over potential scenarios with the gravest of consequences involving hundreds of thousands of casualties. The problem is complicated by the fact that planners have limited, albeit in some cases significant, resources and less than perfect intelligence on potential terrorist plans. However, valuable resources must be used prudently to reduce the overall risk to the nation. A systematicmore » approach to this process of asset allocation is to reduce the overall risk and not just an individual element of risk such as vulnerabilities. Hence, we define risk as a function of three variables: the threat (the likelihood and scenario of the terrorist act), the vulnerability (the vulnerability of potential targets to the threat), and the consequences (health and safety, economic, etc.) resulting from a successful terrorist scenario. Both the vulnerability and consequences from a postulated adversary scenario can be reasonably well estimated. However, the threat likelihood and scenarios are much more difficult to estimate. A possible path forward is to develop scenarios for each potential target in question using experts from many disciplines. This should yield a finite but large number of target-scenario pairs. The vulnerabilities and consequences for each are estimated and then ranked relative to one another. The resulting relative risk ranking will have targets near the top of the ranking for which the threat is estimated to be more likely, the vulnerability greatest, and the consequences the most grave. In the absence of perfect intelligence, this may be the best we can do.« less

  5. Ostracod Geochemistry as a Proxy for Paleoenvironmental Change

    NASA Astrophysics Data System (ADS)

    Carrier, A.; Herrmann, A. D.

    2016-02-01

    Recent studies in the field of paleoceanography suggest that the geochemistry of ostracods, through their uptake of elements from their environment, has the potential to act as proxies for paleoenvironmental change. For example, pH-sensitive elements such as Boron and Uranium potentially record changes in the environment's pH, while temperature sensitive elements Magnesium and Strontium record temperature changes. If this is the case, a random sample of ostracods taken from the same environment should have very little variation in their elemental concentration. This hypothesis was tested using a group of ostracods of the genus Cyprideis taken from a horizon in a hypersaline lake in the southwest of Big Darby Island, Bahamas. Laser-ablation inductively coupled plasma mass spectrometer (LA-ICP-MS) was used in order to measure the elemental concentrations from each ostracod carapace. Despite differences in size and species, the ostracods showed very little variations in Boron and Uranium concentrations. However, Magnesium and Strontium showed more elemental variation in each ostracod. This data suggests that ostracod carapaces do have the potential to act as proxies for environmental pH change; however, their potential to record temperature changes is inconclusive based on these results.

  6. 76 FR 16726 - Eleven Point Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-25

    ... Act. The purpose of the meeting is to review proposed forest management projects so that... meeting will focus on reviewing potential projects that the RAC may recommend for funding. Persons who...

  7. 76 FR 1402 - Eleven Point Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-10

    ... Act. The purpose of the meeting is to review proposed forest management projects so that... meeting will focus on reviewing potential projects that the RAC may recommend for funding. Persons who...

  8. 75 FR 71068 - Eleven Point Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-22

    ... Act. The purpose of the meeting is to review proposed forest management projects so that... conducted: The meeting will focus on reviewing potential projects that the RAC may recommend for funding...

  9. 50 CFR 82.6 - Submission of proposals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... (MARINE MAMMAL PROTECTION ACT OF 1972) Application for Grants § 82.6 Submission of proposals. (a) Preapplication forms may be submitted by any potential grantee in order to (1) establish communication between...

  10. Idraparinux sodium. Sanofi-Aventis.

    PubMed

    Ma, Qing; Fareed, Jawed

    2004-11-01

    Idraparinux sodium, a long-acting anti-Factor Xa synthetic pentasaccharide, is under development by Sanofi-Aventis for the potential prevention and treatment of venous thromboembolic events in patients with deep vein thrombosis or pulmonary embolism.

  11. 32 CFR 842.147 - When authorized.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... where all of the following exist: (a) The potential claimant could file a valid claim for property damage or personal injury under the Military Claims, Foreign Claims, or National Guard Claims Acts. (b...

  12. Exact solution of a ratchet with switching sawtooth potential

    NASA Astrophysics Data System (ADS)

    Saakian, David B.; Klümper, Andreas

    2018-01-01

    We consider the flashing potential ratchet model with general asymmetric potential. Using Bloch functions, we derive equations which allow for the calculation of both the ratchet's flux and higher moments of distribution for rather general potentials. We indicate how to derive the optimal transition rates for maximal velocity of the ratchet. We calculate explicitly the exact velocity of a ratchet with simple sawtooth potential from the solution of a system of 8 linear algebraic equations. Using Bloch functions, we derive the equations for the ratchet with potentials changing periodically with time. We also consider the case of the ratchet with evolution with two different potentials acting for some random periods of time.

  13. In Vitro Activities of Primaquine-Schizonticide Combinations on Asexual Blood Stages and Gametocytes of Plasmodium falciparum

    PubMed Central

    Cabrera, Mynthia

    2015-01-01

    Currently, the World Health Organization recommends addition of a 0.25-mg base/kg single dose of primaquine (PQ) to artemisinin combination therapies (ACTs) for Plasmodium falciparum malaria as a gametocytocidal agent for reducing transmission. Here, we investigated the potential interactions of PQ with the long-lasting components of the ACT drugs for eliminating the asexual blood stages and gametocytes of in vitro-cultured P. falciparum strains. Using the SYBR green I assay for asexual parasites and a flow cytometry-based assay for gametocytes, we determined the interactions of PQ with the schizonticides chloroquine, mefloquine, piperaquine, lumefantrine, and naphthoquine. With the sums of fractional inhibitory concentrations and isobolograms, we were able to determine mostly synergistic interactions for the various PQ and schizonticide combinations on the blood stages of P. falciparum laboratory strains. The synergism in inhibiting asexual stages and gametocytes was highly evident with PQ-naphthoquine, whereas synergism was moderate for the PQ-piperaquine, PQ-chloroquine, and PQ-mefloquine combinations. We have detected potentially antagonistic interactions between PQ and lumefantrine under certain drug combination ratios, suggesting that precautions might be needed when PQ is added as the gametocytocide to the artemether-lumefantrine ACT (Coartem). PMID:26416869

  14. The clinical impact of artemisinin resistance in Southeast Asia and the potential for future spread

    PubMed Central

    Woodrow, Charles J.; White, Nicholas J.

    2017-01-01

    Abstract Artemisinins are the most rapidly acting of currently available antimalarial drugs. Artesunate has become the treatment of choice for severe malaria, and artemisinin-based combination therapies (ACTs) are the foundation of modern falciparum malaria treatment globally. Their safety and tolerability profile is excellent. Unfortunately, Plasmodium falciparum infections with mutations in the ‘K13’ gene, with reduced ring-stage susceptibility to artemisinins, and slow parasite clearance in patients treated with ACTs, are now widespread in Southeast Asia. We review clinical efficacy data from the region (2000–2015) that provides strong evidence that the loss of first-line ACTs in western Cambodia, first artesunate-mefloquine and then DHA-piperaquine, can be attributed primarily to K13 mutated parasites. The ring-stage activity of artemisinins is therefore critical for the sustained efficacy of ACTs; once it is lost, rapid selection of partner drug resistance and ACT failure are inevitable consequences. Consensus methods for monitoring artemisinin resistance are now available. Despite increased investment in regional control activities, ACTs are failing across an expanding area of the Greater Mekong subregion. Although multiple K13 mutations have arisen independently, successful multidrug-resistant parasite genotypes are taking over and threaten to spread to India and Africa. Stronger containment efforts and new approaches to sustaining long-term efficacy of antimalarial regimens are needed to prevent a global malaria emergency. PMID:27613271

  15. The balance between innovation and competition: the Hatch-Waxman Act, the 2003 Amendments, and beyond.

    PubMed

    Kelly, Colleen

    2011-01-01

    In 1984, Congress passed the Hatch-Waxman Act, a landmark statute designed both to encourage innovation by pioneer drug companies and to increase competition by generic drug companies. After its enactment, drug companies attempted to "ga the regulatory regime to their respective economic advantage. In 2003, in an effort to address these issues, FDA promulgated a final rule and Congress passed the Medicare Modernization Act, amending the Hatch-Waxman Act. This article provides a comprehensive look at the 2003 statutory and regulatory changes. First, the article analyzes the history and provisions of the original Hatch-Waxman Act and the issues that arose after its enactment. Second, the article discusses the passage of the 2003 FDA rule and the 2003 Medicare Modernization Act. Next, the article demonstrates that, although the 2003 amendments may have definitively resolved some issues, the amendments did not resolve all interpretive issues and have even led to unintended consequences. In particular, the article discusses several areas of current controversy, including the effect of patent delisting and patent expiration on 180-day exclusivity, the patent delisting counterclaim provision, the declaratory judgment action provision, patent settlement agreements, and authorized generics. Finally, the article assesses the potential for future reform of the Hatch-Waxman Act. The article concludes that maintaining the balance between innovation and competition will likely remain a daunting task for legislators and regulators in the future.

  16. 75 FR 20441 - Authorization of Emergency Use of Certain In Vitro Diagnostic Devices; Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-19

    ...The Food and Drug Administration (FDA) is announcing the issuance of 10 Emergency Use Authorizations (EUAs) (the Authorizations) several of which were amended after initial issuance, for certain in vitro diagnostic devices. FDA also is announcing an amendment to the EUA for the Centers for Disease Control and Prevention (CDC) Swine Influenza Virus Real-time RT-PCR Detection Panel authorized on April 27, 2009. FDA is issuing the Authorizations and amendments thereto under the Federal Food, Drug, and Cosmetic Act (the act). The Authorizations contain, among other things, conditions on the emergency use of the authorized in vitro diagnostics. The Authorizations follow the determination by the Acting Secretary of the U.S. Department of Health and Human Services, Charles E. Johnson (the Acting Secretary), that a public health emergency exists involving Swine Influenza A (now known as 2009 H1N1 Influenza A, or 2009 H1N1 flu) that affects, or has the significant potential to affect, national security. On the basis of such determination, the Acting Secretary declared an emergency justifying the authorization of the emergency use of certain in vitro diagnostics, accompanied by emergency use information subject to the terms of any authorization issued under the Federal Food, Drug, and Cosmetic Act (the act). The Authorizations, which include explanations of the reasons for their issuance or reissuance, are reprinted in this document.

  17. The antiviral activity of arctigenin in traditional Chinese medicine on porcine circovirus type 2.

    PubMed

    Chen, Jie; Li, Wentao; Jin, Erguang; He, Qigai; Yan, Weidong; Yang, Hanchun; Gong, Shiyu; Guo, Yi; Fu, Shulin; Chen, Xiabing; Ye, Shengqiang; Qian, Yunguo

    2016-06-01

    Arctigenin (ACT) is a phenylpropanoid dibenzylbutyrolactone lignan extracted from the traditional herb Arctium lappa L. (Compositae) with anti-viral and anti-inflammatory effects. Here, we investigated the antiviral activity of ACT found in traditional Chinese medicine on porcine circovirus type 2 (PCV2) in vitro and in vivo. Results showed that dosing of 15.6-62.5μg/mL ACT could significantly inhibit the PCV2 proliferation in PK-15 cells (P<0.01). Dosing of 62.5μg/mL ACT 0, 4 or 8h after challenge inoculation significantly inhibited the proliferation of 1MOI and 10MOI in PK-15 cells (P<0.01), and the inhibitory effect of ACT dosing 4h or 8h post-inoculation was greater than 0h after dosing (P<0.01). In vivo test with mice challenge against PCV2 infection demonstrated that intraperitoneal injection of 200μg/kg ACT significantly inhibited PCV2 proliferation in the lungs, spleens and inguinal lymph nodes, with an effect similar to ribavirin, demonstrating the effectiveness of ACT as an antiviral agent against PCV2 in vitro and in vivo. This compound, therefore, may have the potential to serve as a drug for protection of pigs against the infection of PCV2. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Ecological Risk Assessment Process under the Endangered Species Act

    EPA Pesticide Factsheets

    This document provides an overview of the Environmental Protection Agency’s (EPA) ecological risk assessment process for the evaluation of potential risk to endangered and threatened (listed) species from exposure to pesticides.

  19. 75 FR 28234 - Eleven Point Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-20

    ... Act. The purpose of the meeting is to initiate review of proposed forest management projects so that... adopt for conducting business will be on the agenda. Potential projects will also be discussed. Persons...

  20. Basic Information for the Review of New Chemicals

    EPA Pesticide Factsheets

    Mandated by section 5 of the Toxic Substances Control Act (TSCA), EPA's New Chemicals program helps manage the potential risk to human health and the environment from chemicals new to the marketplace.

  1. We Are Not Vidiots.

    ERIC Educational Resources Information Center

    Burns, Grant

    1990-01-01

    Presents arguments in support of public library acquisition of videos. Some potential benefits for children and adults of watching videos are cited, e.g., learning about good acting, screenwriting, cinematography, directing, music, and good literature. (MES)

  2. 76 FR 70728 - Agency Forms Undergoing Paperwork Reduction Act Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-15

    ... stock in the United States and potentially modifiable risk factors. The objectives for developing this... housing-related risk factors. Childhood lead poisoning is just one of many adverse health conditions that...

  3. Air Permitting Streamlining Techniques and Approaches for Greenhouse Gases, 2012

    EPA Pesticide Factsheets

    This report presents potential GHG permit streamlining options and observations developed by the Clean Air Act Advisory Committee (CAAAC): Permits, New Source Review and Toxics Subcommittee GHG Permit Streamlining Workgroup

  4. Ocean Disposal of Marine Mammal Carcasses

    EPA Pesticide Factsheets

    Ocean dumping of marine mammal carcasses is allowed with a permit issued by EPA under the Marine Protection, Research and Sanctuaries Act. Includes permit information, potential environmental impacts, and instructions for getting the general permit.

  5. 29 CFR 801.8 - Employment relationship.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... broadly defines “employer” to include “any person acting directly or indirectly in the interest of an... vocational trade schools with respect to persons who may be referred to potential employers. Such entities...

  6. 76 FR 51344 - Butte County Resource Advisory Committee (RAC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-18

    ... Cycle 2 project applications for potential funding recommendations to Lassen, Plumas or Mendocino... Schools and Community Self-Determination Act of 2000. This is the last cycle of funding under the current...

  7. 33 CFR 325.1 - Applications for permits.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... assure that the potential applicant is fully aware of the substance (both quantitative and qualitative... Protection, Research and Sanctuaries Act of 1972, as amended, and sections 9 and 10 of the Rivers and Harbors...

  8. 33 CFR 325.1 - Applications for permits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... assure that the potential applicant is fully aware of the substance (both quantitative and qualitative... Protection, Research and Sanctuaries Act of 1972, as amended, and sections 9 and 10 of the Rivers and Harbors...

  9. 33 CFR 325.1 - Applications for permits.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... assure that the potential applicant is fully aware of the substance (both quantitative and qualitative... Protection, Research and Sanctuaries Act of 1972, as amended, and sections 9 and 10 of the Rivers and Harbors...

  10. 33 CFR 325.1 - Applications for permits.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... assure that the potential applicant is fully aware of the substance (both quantitative and qualitative... Protection, Research and Sanctuaries Act of 1972, as amended, and sections 9 and 10 of the Rivers and Harbors...

  11. 33 CFR 325.1 - Applications for permits.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... assure that the potential applicant is fully aware of the substance (both quantitative and qualitative... Protection, Research and Sanctuaries Act of 1972, as amended, and sections 9 and 10 of the Rivers and Harbors...

  12. What Teachers Perceive--Children Receive?

    ERIC Educational Resources Information Center

    Algozzine, Robert

    1976-01-01

    Reports a study designed to ascertain the relationship between teacher perceived attractiveness and classroom interactions and suggests that "main effects" such as facial attractiveness of youngsters acts to determine individual potential for interactions with others. (MH)

  13. A behavioral perspective on fishing-induced evolution.

    PubMed

    Uusi-Heikkilä, Silva; Wolter, Christian; Klefoth, Thomas; Arlinghaus, Robert

    2008-08-01

    The potential for excessive and/or selective fishing to act as an evolutionary force has been emphasized recently. However, most studies have focused on evolution of life-history traits in response to size-selective harvesting. Here we draw attention to fishing-induced evolution of behavioral and underlying physiological traits. We contend that fishing-induced selection directly acting on behavioral rather than on life-history traits per se can be expected in all fisheries that operate with passive gears such as trapping, angling and gill-netting. Recent artificial selection experiments in the nest-guarding largemouth bass Micropterus salmoides suggest that fishing-induced evolution of behavioral traits that reduce exposure to fishing gear might be maladaptive, potentially reducing natural recruitment. To improve understanding and management of fisheries-induced evolution, we encourage greater application of methods from behavioral ecology, physiological ecology and behavioral genetics.

  14. Quantum chemical characterization of zwitterionic structures: Supramolecular complexes for modifying the wettability of oil-water-limestone system.

    PubMed

    Lopez-Chavez, Ernesto; Garcia-Quiroz, Alberto; Gonzalez-Garcia, Gerardo; Orozco-Duran, Gabriela E; Zamudio-Rivera, Luis S; Martinez-Magadan, José M; Buenrostro-Gonzalez, Eduardo; Hernandez-Altamirano, Raul

    2014-06-01

    In this work, we present a quantum chemical study pertaining to some supramolecular complexes acting as wettability modifiers of oil-water-limestone system. The complexes studied are derived from zwitterionic liquids of the types N'-alkyl-bis, N-alquenil, N-cycloalkyl, N-amyl-bis-beta amino acid or salts acting as sparkling agents. We studied two molecules of zwitterionic liquids (ZL10 and ZL13), HOMO and LUMO levels, and the energy gap between them, were calculated, as well as the electron affinity (EA) and ionization potential (IP), chemical potential, chemical hardness, chemical electrophilicity index and selectivity descriptors such Fukui indices. In this work, electrochemical comparison was realized with cocamidopropyl betaine (CPB), which is a structure zwitterionic liquid type, nowadays widely applied in enhanced recovery processes. Copyright © 2014 Elsevier Inc. All rights reserved.

  15. Reauthorization of Toxic Substances Control Act for fiscal year 1984. Hearing before the Subcommittee on Commerce, Transportation, and Tourism of the Committee on Energy and Commerce, House of Representatives, Ninety-Eighth Congress, First Session, April 21, 1983

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1983-01-01

    A hearing to reauthorize the Toxic Substances Control Act (TSCA) reviewed evidence that few new chemicals introduced into the consumer market are tested for toxicity and that no testing rules have been issued in the seven years of TSCA's existence in contrast to the testing record of some European countries. The 13 witnesses represented the Chamber of Commerce, conservation and environmental groups and agencies, and manufacturers of potentially toxic materials. The latter cited the economic burden on small businesses and the constraints on innovation that TSCA has had. Others stressed potential health hazards from untested materials and the poor recordmore » of TSCA implementation. (DCK)« less

  16. Work, Health, And Insurance: A Shifting Landscape For Employers And Workers Alike.

    PubMed

    Buchmueller, Thomas C; Valletta, Robert G

    2017-02-01

    We examined the complex relationship among work, health, and health insurance, which has been affected by changing demographics and employment conditions in the United States. Stagnation or deterioration in employment conditions and wages for much of the workforce has been accompanied by the erosion of health outcomes and employer-sponsored insurance coverage. In this article we present data and discuss the research that has established these links, and we assess the potential impact of policy responses to the evolving landscape of work and health. The expansion of insurance availability under the Affordable Care Act may have helped reduce the burden on employers to provide health insurance. However, the act's encouragement of wellness programs has uncertain potential to help contain the rising costs of employer-sponsored health benefits. Project HOPE—The People-to-People Health Foundation, Inc.

  17. Infidelity, trust, and condom use among Latino youth in dating relationships.

    PubMed

    Brady, Sonya S; Tschann, Jeanne M; Ellen, Jonathan M; Flores, Elena

    2009-04-01

    Latino youth in the United States are at greater risk for contracting sexually transmitted infections (STIs) in comparison with non-Hispanic white youth. Sexually active heterosexual Latino youth aged 16 to 22 years (N = 647) were recruited for interviews through a large health maintenance organization or community clinics. Adjusting for gender, age, ethnic heritage, and recruitment method, woman's consistent use of hormonal contraceptives, ambivalence about avoiding pregnancy, longer length of sexual relationship, and greater overall trust in main partner were independently associated with inconsistent condom use and engagement in a greater number of sexual intercourse acts that were unprotected by condom use. Perception that one's main partner had potentially been unfaithful, but not one's own sexual concurrency, was associated with consistent condom use and fewer acts of unprotected sexual intercourse. Sexually concurrent youth who engaged in inconsistent condom use with other partners were more likely to engage in inconsistent condom use and a greater number of unprotected sexual intercourse acts with main partners. Increasing attachment between youth may be a risk factor for the transmission of STIs via normative declines in condom use. Perception that one's partner has potentially been unfaithful may result in greater condom use. However, many Latino adolescents and young adults who engage in sexual concurrency may not take adequate steps to protect their partners from contracting STIs. Some youth may be more focused on the emotional and social repercussions of potentially revealing infidelity by advocating condom use than the physical repercussions of unsafe sex.

  18. Possible long-acting risperidone-induced hypothermia precipitating phenytoin toxicity in an elderly patient.

    PubMed

    Brandon Bookstaver, P; Miller, A D

    2011-06-01

    Thermodysregulation, including hypothermia, is recognized as a potential adverse effect secondary to atypical antipsychotics. We report the first known case of hypothermia possibly associated with long-acting risperidone depot injection, precipitating further adverse events secondary to supratherapeutic phenytoin concentrations. A 75-year-old African-American female presented as a transfer from an outpatient psychiatric center with hypothermia (35·1 °C), bradycardia, altered mental status and a series of witnessed tonic-clonic seizures. The patient was discovered to be profoundly neutropenic (absolute neutrophil count = 266 × 10(9) /L) and a corrected phenytoin concentration was 147·708 μm. During the 3 months preceding admission, phenytoin dosing was stable and consecutive therapeutic concentrations were documented. The only recent change in medication regimen was a switch from oral risperidone to the long-acting injectable formulation. Upon discontinuation of the risperidone and phenytoin, the patient's mental status and laboratory abnormalities returned to baseline. The patient did not experience additional seizure activity. This unintentional significant drop in core body temperature may have resulted in altered metabolism of phenytoin leading to supratherapeutic concentrations and subsequent tonic-clonic seizures, bradycardia and neutropenia. Low core body temperatures can alter the pharmacokinetic profiles of hepatically metabolized medications, prompting careful patient assessment especially in those receiving medications with a narrow-therapeutic index. Hypothermia should be recognized as a potential adverse event with the long-acting injectable formulation of risperidone. © 2010 The Authors. JCPT © 2010 Blackwell Publishing Ltd.

  19. Oregon's Toxic Household Products Law.

    PubMed

    Neumann, C M; Giffin, S; Hall, R; Henderson, M; Buhler, D R

    2000-01-01

    In 1991, Oregon became the first state in the U.S. to require the addition of an aversive agent to ethylene glycol-containing antifreeze and methanol-containing windshield wiper fluid. This new law, entitled "Toxic Household Products (THP) Act," was designed to reduce pediatric and animal poisonings from accidental ingestion of these two potentially lethal consumer automotive products. While not the stated intention of the law, addition of aversive agents to consumer automotive products could also reduce adult poisonings associated with intentional (suicides or alcoholics ingesting methanol-containing windshield wiper fluid) or accidental exposures. This law went into effect April 30, 1995, following settlement of a lawsuit brought by the Chemical Manufacturing Specialties Association (CSMA), a trade group representing the five largest manufacturers of ethylene glycol-based antifreeze in the U.S. This paper discusses the major policy issues that arose following the passage of Oregon's THP Act. Major provisions of the law are provided along with a discussion of CSMA's opposition to the Act's implementation. A description of the eventual settlement that was reached with CSMA as well as the major components of Oregon Health Division's (OHD) enforcement program are also highlighted. Data are presented for 1987 through 1998 on the number of exposures and severity of effects for pediatric cases (children < 6 years old) following exposure to both of these potentially lethal automotive products. However, because of the low incidence of exposures each year, these data are insufficient to draw any conclusions on the impact of the THP Act.

  20. Involvement of AMPA receptors in the antidepressant-like effects of dextromethorphan in mice.

    PubMed

    Nguyen, Linda; Matsumoto, Rae R

    2015-12-15

    Dextromethorphan (DM) is an antitussive with rapid acting antidepressant potential based on pharmacodynamic similarities to ketamine. Building upon our previous finding that DM produces antidepressant-like effects in the mouse forced swim test (FST), the present study aimed to establish the antidepressant-like actions of DM in the tail suspension test (TST), another well-established model predictive of antidepressant efficacy. Additionally, using the TST and FST, we investigated the role of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors in the antidepressant-like properties of DM because accumulating evidence suggests that AMPA receptors play an important role in the pathophysiology of depression and may contribute to the efficacy of antidepressant medications, including that of ketamine. We found that DM displays antidepressant-like effects in the TST similar to the conventional and fast acting antidepressants characterized by imipramine and ketamine, respectively. Moreover, decreasing the first-pass metabolism of DM by concomitant administration of quinidine (CYP2D6 inhibitor) potentiated antidepressant-like actions, implying DM itself has antidepressant efficacy. Finally, in both the TST and FST, pretreatment with the AMPA receptor antagonist NBQX (2,3-dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide) significantly attenuated the antidepressant-like behavior elicited by DM. Together, the data show that DM exerts antidepressant-like actions through AMPA receptors, further suggesting DM may act as a safe and effective fast acting antidepressant drug. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. Medicaid expansion under the Affordable Care Act. Implications for insurance-related disparities in pulmonary, critical care, and sleep.

    PubMed

    Lyon, Sarah M; Douglas, Ivor S; Cooke, Colin R

    2014-05-01

    The Affordable Care Act was intended to address systematic health inequalities for millions of Americans who lacked health insurance. Expansion of Medicaid was a key component of the legislation, as it was expected to provide coverage to low-income individuals, a population at greater risk for disparities in access to the health care system and in health outcomes. Several studies suggest that expansion of Medicaid can reduce insurance-related disparities, creating optimism surrounding the potential impact of the Affordable Care Act on the health of the poor. However, several impediments to the implementation of Medicaid's expansion and inadequacies within the Medicaid program itself will lessen its initial impact. In particular, the Supreme Court's decision to void the Affordable Care Act's mandate requiring all states to accept the Medicaid expansion allowed half of the states to forego coverage expansion, leaving millions of low-income individuals without insurance. Moreover, relative to many private plans, Medicaid is an imperfect program suffering from lower reimbursement rates, fewer covered services, and incomplete acceptance by preventive and specialty care providers. These constraints will reduce the potential impact of the expansion for patients with respiratory and sleep conditions or critical illness. Despite its imperfections, the more than 10 million low-income individuals who gain insurance as a result of Medicaid expansion will likely have increased access to health care, reduced out-of-pocket health care spending, and ultimately improvements in their overall health.

  2. The Impact on DoD of the Toxic Substances Control Act

    DTIC Science & Technology

    1980-06-01

    reconcile a limit of 10 ppm in the gasoline area where there is a potential for 400,000 exposures while in the rubber industry the potential is only 150,000...that the Ames test and other mutagenic tests are predictive of tumor producing potential. Many of us in toxi - cology are not impressed with this...also be completely different; so much for generic toxi - cology and for the possibility that short term testing for mutagenic effects is predictive of

  3. Contributions of the Transonic Dynamics Tunnel to the Testing of Active Control of Aeroelastic Response

    NASA Technical Reports Server (NTRS)

    Perry, Boyd, III; Noll, Thomas E.; Scott, Robert C.

    2000-01-01

    By the 1960s, researchers began to investigate the feasibility of using active controls technology (ACT) for increasing the capabilities of military and commercial aircraft. Since then many researchers, too numerous to mention, have investigated and demonstrated the usefulness of ACT for favorably modifying the aeroelastic response characteristics of flight vehicles. As a result, ACT entered the limelight as a viable tool for answering some very difficult design questions and had the potential for obtaining structural weight reductions optimizing maneuvering performance, and satisfying the multimission requirements being imposed on future military and commercial aircraft designs. Over the past 40 years, the NASA Langley Research Center (LaRC) has played a major role in developing ACT in part by its participation in many wind-tunnel programs conducted in the Transonic Dynamics Tunnel (TDT). These programs were conducted for the purposes of: (1) establishing concept feasibility; (2) demonstrating proof of concept; and (3) providing data for validating new modeling, analysis, and design methods. This paper provides an overview of the ACT investigations conducted in the TDT. For each program discussed herein, the objectives of the effort, the testing techniques, the test results, any, signIficant findings, and the lessons learned with respect to ACT testing are presented.

  4. A New Model for Allosteric Regulation of Phenylalanine Hydroxylase: Implications for Disease and Therapeutics

    PubMed Central

    Stith, Linda; Lawrence, Sarah H.; Andrake, Mark; Dunbrack, Roland L.

    2013-01-01

    The structural basis for allosteric regulation of phenylalanine hydroxylase (PAH), whose dysfunction causes phenylketonuria (PKU), is poorly understood. A new morpheein model for PAH allostery is proposed to consist of a dissociative equilibrium between two architecturally different tetramers whose interconversion requires a ~90° rotation between the PAH catalytic and regulatory domains, the latter of which contains an ACT domain. This unprecedented model is supported by in vitro data on purified full length rat and human PAH. The conformational change is both predicted to and shown to render the tetramers chromatographically separable using ion exchange methods. One novel aspect of the activated tetramer model is an allosteric phenylalanine binding site at the inter-subunit interface of ACT domains. Amino acid ligand-stabilized ACT domain dimerization follows the multimerization and ligand binding behavior of ACT domains present in other proteins in the PDB. Spectroscopic, chromatographic, and electrophoretic methods demonstrate a PAH equilibrium consisting of two architecturally distinct tetramers as well as dimers. We postulate that PKU-associated mutations may shift the PAH quaternary structure equilibrium in favor of the low activity assemblies. Pharmacological chaperones that stabilize the ACT:ACT interface can potentially provide PKU patients with a novel small molecule therapeutic. PMID:23296088

  5. A randomized noninferiority trial of standard versus enhanced risk reduction and adherence counseling for individuals receiving post-exposure prophylaxis following sexual exposures to HIV.

    PubMed

    Roland, Michelle E; Neilands, Torsten B; Krone, Melissa R; Coates, Thomas J; Franses, Karena; Chesney, Margaret A; Kahn, James S; Martin, Jeffrey N

    2011-07-01

    The National HIV/AIDS Strategy proposes to scale-up post-exposure prophylaxis (PEP). Intensive risk reduction and adherence counseling appear to be effective but are resource intensive. Identifying simpler interventions that maximize the HIV prevention potential of PEP is critical. A randomized noninferiority study comparing 2 (standard) or 5 (enhanced) risk reduction counseling sessions was performed. Adherence counseling was provided in the enhanced arm. We measured changes in unprotected sexual intercourse acts at 12 months, compared with baseline; HIV acquisition; and PEP adherence. Outcomes were stratified by degree of baseline risk. We enrolled 457 individuals reporting unprotected intercourse within 72 h with an HIV-infected or at-risk partner. Participants were 96% male and 71% white. There were 1.8 and 2.3 fewer unprotected sex acts in the standard and enhanced groups. The maximum potential risk difference, reflected by the upper bound of the 95% confidence interval, was 3.9 acts. The difference in the riskier subset may have been as many as 19.6 acts. The incidence of HIV seroconversion was 2.9% and 2.6% among persons randomized to standard and enhanced counseling, respectively, with a maximum potential difference of 3.4%. The absolute and maximal HIV seroconversion incidence was 9.9% and 20.4% greater in the riskier group randomized to standard, compared with enhanced, counseling. Adherence outcomes were similar, with noninferiority in the lower risk group and concerning differences among the higher-risk group. Risk assessment is critical at PEP initiation. Standard counseling is only noninferior for individuals with lower baseline risk; thus, enhanced counseling should be targeted to individuals at higher risk. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.

  6. LCK rank of locally conformally Kähler manifolds with potential

    NASA Astrophysics Data System (ADS)

    Ornea, Liviu; Verbitsky, Misha

    2016-09-01

    An LCK manifold with potential is a quotient of a Kähler manifold X equipped with a positive Kähler potential f, such that the monodromy group acts on X by holomorphic homotheties and multiplies f by a character. The LCK rank is the rank of the image of this character, considered as a function from the monodromy group to real numbers. We prove that an LCK manifold with potential can have any rank between 1 and b1(M) . Moreover, LCK manifolds with proper potential (ones with rank 1) are dense. Two errata to our previous work are given in the last section.

  7. Did the No Child Left Behind Act Miss the Mark? Assessing the Potential Benefits from an Accountability System for Early Childhood Education

    ERIC Educational Resources Information Center

    Miller, Lawrence J.; Smith, Stephanie C.

    2011-01-01

    With growing evidence that human capital investment is more efficiently spent on younger children coupled with wide variation in preschool access across states, this article uses a neoliberal approach to examine the potential social costs and benefits that could accrue should the United States decide to implement a centralized preschool…

  8. 25 CFR 224.137 - What must the Director do if a tribe's noncompliance has resulted in harm or the potential for...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... resulted in harm or the potential for harm to a physical trust asset? 224.137 Section 224.137 Indians... AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Periodic Reviews Noncompliance § 224.137 What must the Director do if a tribe's noncompliance has resulted in harm or the...

  9. 25 CFR 224.137 - What must the Director do if a tribe's noncompliance has resulted in harm or the potential for...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... resulted in harm or the potential for harm to a physical trust asset? 224.137 Section 224.137 Indians... AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Periodic Reviews Noncompliance § 224.137 What must the Director do if a tribe's noncompliance has resulted in harm or the...

  10. 25 CFR 224.137 - What must the Director do if a tribe's noncompliance has resulted in harm or the potential for...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... resulted in harm or the potential for harm to a physical trust asset? 224.137 Section 224.137 Indians... AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Periodic Reviews Noncompliance § 224.137 What must the Director do if a tribe's noncompliance has resulted in harm or the...

  11. 25 CFR 224.137 - What must the Director do if a tribe's noncompliance has resulted in harm or the potential for...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... resulted in harm or the potential for harm to a physical trust asset? 224.137 Section 224.137 Indians... AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Periodic Reviews Noncompliance § 224.137 What must the Director do if a tribe's noncompliance has resulted in harm or the...

  12. Rothe Development Corporation v. Department of Defense: The Constitutionality of Federal Contracting Programs for Minority-Owned and Other Small Businesses

    DTIC Science & Technology

    2009-04-14

    and analyzes Rothe’s potential effect on these programs, including the Business Development Program under Section 8(a) of the Small Business Act...13 Potential Vulnerability of Existing Programs... Newell , Decision in Defense Procurement Case Could Set Precedent, GovExec.com, Nov. 11, 2008, available at http://www.govexec.com/dailyfed/1108

  13. 76 FR 55393 - Agency Forms Undergoing Paperwork Reduction Act Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-07

    ... temporary housing units deployed in the Gulf Coast region following hurricanes Katrina and Rita. The title... housing units following hurricanes Katrina and Rita, and who were potentially exposed to higher levels of...

  14. 75 FR 27264 - Video Device Competition; Implementation of Section 304 of the Telecommunications Act of 1996...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-14

    ... and Consumer Electronics Equipment AGENCY: Federal Communications Commission. ACTION: Notice of... explore the potential for allowing any electronics manufacturer to offer smart video devices at retail...

  15. 76 FR 45163 - Anniversary of the Americans With Disabilities Act, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-28

    ... educational opportunities as their peers and are gaining the tools necessary to reach their greatest potential... Department of Justice continues to strengthen enforcement of the ADA by ensuring that persons with...

  16. 75 FR 38457 - Eleven Point Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-02

    ... Act. The purpose of the meeting is initiate review of proposed forest management projects so that... meeting will begin to focus on the potential projects that the RAC will be reviewing. Persons who wish to...

  17. 75 FR 47535 - Eleven Point Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-06

    ... Act. The purpose of the meeting is to initiate review of proposed forest management projects so that... conducted: The meeting will begin to focus on the potential projects that the RAC will be reviewing. Persons...

  18. 75 FR 59680 - Eleven Point Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-28

    ... Act. The purpose of the meeting is initiate review of proposed forest management projects so that... meeting will begin to focus on the potential projects that the RAC will be reviewing. Persons who wish to...

  19. PAST - THE POTENTIAL ARARS SELECTION TOOL

    EPA Science Inventory

    The 1986 Superfund Amendments and Reauthorization Act (SARA) specified that any remedial actions at Superfund sites must comply with applicable or relevant and appropriate regulations (ARARS), including Federal, state, and local environmental statutes. Identifying these legal req...

  20. 12 CFR Appendix B to Part 749 - Catastrophic Act Preparedness Guidelines

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... disaster. (1) A business impact analysis to evaluate potential threats; (2) A risk assessment to determine... the plan; ii. Preservation and ability to restore vital records; iii. A method for restoring vital...

  1. Scientific Advisory Panel to Meet on Cancer Potential of Glyphosate

    EPA Pesticide Factsheets

    The Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel (SAP) will meet October 18-21, 2016, to consider and review a set of scientific issues being evaluated by the regarding EPA's evaluation

  2. In Silico Studies of the Toxcast Chemicals Interacting with Biomolecular targets

    EPA Science Inventory

    Molecular docking, a structure-based in silico tool for chemical library pre-screening in drug discovery, can be used to explore the potential toxicity of environmental chemicals acting at specific biomelcular targets.

  3. Mobilizing a University at a Time of Crisis.

    ERIC Educational Resources Information Center

    Jackson, Michael L.

    2002-01-01

    Describes how the University of Southern California's varied human resources, from security staff to presidential leadership, were called upon to respond to potential threats to the university's core mission posed by recent terrorist acts. (EV)

  4. Direct-acting antiviral therapy decreases hepatocellular carcinoma recurrence rate in cirrhotic patients with chronic hepatitis C.

    PubMed

    Virlogeux, Victor; Pradat, Pierre; Hartig-Lavie, Kerstin; Bailly, François; Maynard, Marianne; Ouziel, Guillaume; Poinsot, Domitille; Lebossé, Fanny; Ecochard, Marie; Radenne, Sylvie; Benmakhlouf, Samir; Koffi, Joseph; Lack, Philippe; Scholtes, Caroline; Uhres, Anne-Claire; Ducerf, Christian; Mabrut, Jean-Yves; Rode, Agnès; Levrero, Massimo; Combet, Christophe; Merle, Philippe; Zoulim, Fabien

    2017-08-01

    Arrival of direct-acting antiviral agents against hepatitis C virus with high-sustained virological response rates and very few side effects has drastically changed the management of hepatitis C virus infection. The impact of direct-acting antiviral exposure on hepatocellular carcinoma recurrence after a first remission in patients with advanced fibrosis remains to be clarified. 68 consecutive hepatitis C virus patients with a first hepatocellular carcinoma diagnosis and under remission, subsequently treated or not with a direct-acting antiviral combination, were included. Clinical, biological and virological data were collected at first hepatocellular carcinoma diagnosis, at remission and during the surveillance period. All patients were cirrhotic. Median age was 62 years and 76% of patients were male. Twenty-three patients (34%) were treated with direct-acting antivirals and 96% of them achieved sustained virological response. Median time between hepatocellular carcinoma remission and direct-acting antivirals initiation was 7.2 months (IQR: 3.6-13.5; range: 0.3-71.4) and median time between direct-acting antivirals start and hepatocellular carcinoma recurrence was 13.0 months (IQR: 9.2-19.6; range: 3.0-24.7). Recurrence rate was 1.7/100 person-months among treated patients vs 4.2/100 person-months among untreated patients (P=.008). In multivariate survival analysis, the hazard ratio for hepatocellular carcinoma recurrence after direct-acting antivirals exposure was 0.24 (95% confidence interval: 0.10-0.55; P<.001). Hepatocellular carcinoma recurrence rate was significantly lower among patients treated with direct-acting antivirals compared with untreated patients. Given the potential impact of our observation, large-scale prospective cohort studies are needed to confirm these results. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  5. Administration of adjuvant chemotherapy for stage II-III colon cancer patients: An European population-based study.

    PubMed

    Babaei, Masoud; Balavarca, Yesilda; Jansen, Lina; Lemmens, Valery; van Erning, Felice N; van Eycken, Liesbet; Vaes, Evelien; Sjövall, Annika; Glimelius, Bengt; Ulrich, Cornelia M; Schrotz-King, Petra; Brenner, Hermann

    2018-04-01

    The advantage of adjuvant chemotherapy (ACT) for treating Stage III colon cancer patients is well established and widely accepted. However, many patients with Stage III colon cancer do not receive ACT. Moreover, there are controversies around the effectiveness of ACT for Stage II patients. We investigated the administration of ACT and its association with overall survival in resected Stage II (overall and stratified by low-/high-risk) and Stage III colon cancer patients in three European countries including The Netherlands (2009-2014), Belgium (2009-2013) and Sweden (2009-2014). Hazard ratios (HR) for death were obtained by Cox regression models adjusted for potential confounders. A total of 60244 resected colon cancer patients with pathological Stages II and III were analyzed. A small proportion (range 9-24%) of Stage II and over half (range 55-68%) of Stage III patients received ACT. Administration of ACT in Stages II and III tumors decreased with higher age of patients. Administration of ACT was significantly associated with higher overall survival in high-risk Stage II patients (in The Netherlands (HR; 95%CI = 0.82 (0.67-0.99), Belgium (0.73; 0.59-0.90) and Sweden (0.58; 0.44-0.75)), and in Stage III patients (in The Netherlands (0.47; 0.43-0.50), Belgium (0.46; 0.41-0.50) and Sweden (0.48; 0.43-0.54)). In Stage III, results were consistent across subgroups including elderly patients. Our results show an association of ACT with higher survival among Stage III and high-risk Stage II colon cancer patients. Further investigations are needed on the selection criteria of Stages II and III colon cancer patients for ACT. © 2017 UICC.

  6. Dynamical potentials for nonequilibrium quantum many-body phases

    NASA Astrophysics Data System (ADS)

    Roy, Sthitadhi; Lazarides, Achilleas; Heyl, Markus; Moessner, Roderich

    2018-05-01

    Out of equilibrium phases of matter exhibiting order in individual eigenstates, such as many-body localized spin glasses and discrete time crystals, can be characterized by inherently dynamical quantities such as spatiotemporal correlation functions. In this paper, we introduce dynamical potentials which act as generating functions for such correlations and capture eigenstate phases and order. These potentials show formal similarities to their equilibrium counterparts, namely thermodynamic potentials. We provide three representative examples: a disordered XXZ chain showing many-body localization, a disordered Ising chain exhibiting spin-glass order, and its periodically-driven cousin exhibiting time-crystalline order.

  7. Environmental Analysis of Endocrine Disrupting Effects from Hydrocarbon Contaminants in the Ecosystem - Final Report - 09/15/1996 - 09/14/2000

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    McLachlan, John A.

    The three major components of the research included: (a) a biotechnology based screening system to identify potential hormone mimics and antagonists (b) an animal screening system to identify biomarkers of endocrine effects and (c) a literature review to identify compounds at various DOE sites that are potential endocrine disruptors. Species of particular interest in this study were those that can serve as sentinel species (e.g., amphibians) and thus provide early warning signals for more widespread impacts on an ecosystem and its wildlife and human inhabitants. The objective of this basic research is to characterize the potential of common hydrocarbon contaminantsmore » in ecosystems to act as endocrine disruptors. Although the endocrine disrupting effects of contaminants such as dioxin and PCBs have been well characterized in both animals and humans, little is known about the capacities of other hydrocarbon contaminants to act as endocrine disruptors. Results obtained from this research project have provided information on endocrine disrupting contaminants for consideration in DOE's risk analyses for determining clean-up levels and priorities at contaminated DOE sites.« less

  8. Suppression of transient receptor potential melastatin 4 expression promotes conversion of endothelial cells into fibroblasts via transforming growth factor/activin receptor-like kinase 5 pathway.

    PubMed

    Echeverría, Cesar; Montorfano, Ignacio; Cabello-Verrugio, Claudio; Armisén, Ricardo; Varela, Diego; Simon, Felipe

    2015-05-01

    To study whether transient receptor potential melastatin 4 (TRPM4) participates in endothelial fibrosis and to investigate the underlying mechanism. Primary human endothelial cells were used and pharmacological and short interfering RNA-based approaches were used to test the transforming growth factor beta (TGF-β)/activin receptor-like kinase 5 (ALK5) pathway participation and contribution of TRPM7 ion channel. Suppression of TRPM4 expression leads to decreased endothelial protein expression and increased expression of fibrotic and extracellular matrix markers. Furthermore, TRPM4 downregulation increases intracellular Ca levels as a potential condition for fibrosis. The underlying mechanism of endothelial fibrosis shows that inhibition of TRPM4 expression induces TGF-β1 and TGF-β2 expression, which act through their receptor, ALK5, and the nuclear translocation of the profibrotic transcription factor smad4. TRPM4 acts to maintain endothelial features and its loss promotes fibrotic conversion via TGF-β production. The regulation of TRPM4 levels could be a target for preserving endothelial function during inflammatory diseases.

  9. Gum tragacanth stabilized green gold nanoparticles as cargos for Naringin loading: A morphological investigation through AFM.

    PubMed

    Rao, Komal; Imran, Muhammad; Jabri, Tooba; Ali, Imdad; Perveen, Samina; Shafiullah; Ahmed, Shakil; Shah, Muhammad Raza

    2017-10-15

    Gold nanoparticles (AuNPs) have attracted greater scientific interests for the construction of drugs loading cargos due to their biocompatibility, safety and facile surface modifications. This study deals with the fabrication of gum tragacanth (GT) green AuNPs as carrier for Naringin, a less water soluble therapeutic molecule. The optimized AuNPs were characterized through UV-vis spectroscopy, FT-IR and atomic force microscope (AFM). Naringin loaded nanoparticles were investigated for their bactericidal potentials using Tetrazolium Microplate assay. Morphological studies conducted via AFM revealed spherical shape for AuNPs with nano-range size and stabilized by GT multi-functional groups. The AuNPs acted as carrier for increased amount of Naringin. Upon loading in AuNPs, Naringin An increased in the bactericidal potentials of Naringin was observed after loading on AuNPs against various tested bacterial strains. This was further authenticated by the surface morphological analysis, showing enhanced membrane destabilizing effects of loaded Naringin. The results suggest that GT stabilized green AuNPs can act as effective delivery vehicles for enhancing bactericidal potentials of Naringin. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Slugs: potential novel vectors of Escherichia coli O157.

    PubMed

    Sproston, Emma L; Macrae, M; Ogden, Iain D; Wilson, Michael J; Strachan, Norval J C

    2006-01-01

    Field and laboratory studies were performed to determine whether slugs could act as novel vectors for pathogen (e.g., Escherichia coli O157) transfer from animal feces to salad vegetables. Escherichia coli O157 was isolated from 0.21% of field slugs from an Aberdeenshire sheep farm. These isolates carried the verocytotoxin genes (vt1 and vt2) and the attaching and effacing gene (eae), suggesting that they are potentially pathogenic to humans. Strain typing using multilocus variable number tandem repeats analysis showed that slug and sheep isolates were indistinguishable. Laboratory experiments using an E. coli mutant resistant to nalidixic acid showed that the ubiquitous slug species Deroceras reticulatum could carry viable E. coli on its external surface for up to 14 days. Slugs that had been fed E. coli shed viable bacteria in their feces with numbers showing a short but statistically significant linear log decline. Further, it was found that E. coli persisted for up to 3 weeks in excreted slug feces, and hence, we conclude that slugs have the potential to act as novel vectors of E. coli O157.

  11. Slugs: Potential Novel Vectors of Escherichia coli O157

    PubMed Central

    Sproston, Emma L.; Macrae, M.; Ogden, Iain D.; Wilson, Michael J.; Strachan, Norval J. C.

    2006-01-01

    Field and laboratory studies were performed to determine whether slugs could act as novel vectors for pathogen (e.g., Escherichia coli O157) transfer from animal feces to salad vegetables. Escherichia coli O157 was isolated from 0.21% of field slugs from an Aberdeenshire sheep farm. These isolates carried the verocytotoxin genes (vt1 and vt2) and the attaching and effacing gene (eae), suggesting that they are potentially pathogenic to humans. Strain typing using multilocus variable number tandem repeats analysis showed that slug and sheep isolates were indistinguishable. Laboratory experiments using an E. coli mutant resistant to nalidixic acid showed that the ubiquitous slug species Deroceras reticulatum could carry viable E. coli on its external surface for up to 14 days. Slugs that had been fed E. coli shed viable bacteria in their feces with numbers showing a short but statistically significant linear log decline. Further, it was found that E. coli persisted for up to 3 weeks in excreted slug feces, and hence, we conclude that slugs have the potential to act as novel vectors of E. coli O157. PMID:16391036

  12. Overview of the ACT program

    NASA Technical Reports Server (NTRS)

    Davis, John G., Jr.

    1992-01-01

    NASA's Advanced Composites Program (ACT) was initiated in 1988. A National Research Announcement was issued to solicit innovative ideas that could significantly contribute to development and demonstration of an integrated technology data base and confidence level that permits cost-effective use of composite primary structures in transport aircraft. Fifteen contracts were awarded by the Spring of 1989 and the participants include commercial and military airframe manufacturers, materials developers and suppliers, universities, and government laboratories. The program approach is to develop materials, structural mechanics methodology, design concepts, and fabrication procedures that offer the potential to make composite structures cost-effective compared to aluminum structure. Goals for the ACT program included 30-50 percent weight reduction, 20-25 percent acquisition cost reduction, and provided the scientific basis for predicting materials and structures performance. This paper provides an overview of the ACT program status, plans, and selected technical accomplishments. Sixteen additional papers, which provide more detailed information on the research and development accomplishments, are contained in this publication.

  13. Mineral resource potential map of the Kalmiopsis Wilderness, southwestern Oregon

    USGS Publications Warehouse

    Page, Norman J; Miller, Michael S.; Grimes, David J.; Leinz, Reinhard W.; Blakely, Richard J.; Lipin, Bruce R.; Foose, Michael P.; Gray, Floyd

    1982-01-01

    Under the provisions of the Wilderness Act (Public Law 88-577, September 3, 1964) and the Joint conference Report on Senate Bill 4, 88th Congress, the U.S. Geological Survey and the U.S. Bureau of Mines have been conducting mineral surveys of wilderness and primitive areas. Areas officially designated as "wilderness," wild," or "canoe" when the act was passed were incorporated into the National Wilderness Preservation System, and some of them are presently being studied. The act provided that areas under consideration for wilderness designation should be studied for suitability for incorporation into the Wilderness System. The mineral surveys constitute one aspect of the suitability studies. The act directs that the results of such surveys are to be made available to the public and be submitted to the President and the Congress. This report discusses the results of a mineral survey of the Kalmiopsis Wilderness, Siskiyou National Forest, Josephine and Curry Counties, Oregon. The area was established as a wilderness by Public Law 88-577, September 1964.

  14. Preparing for the physician payment sunshine act.

    PubMed

    Dickerson, David M; Naidu, Ramana K

    2014-01-01

    In March of 2010, President Barack Obama signed into law the Patient Protection and Affordable Care Act, ushering in an era of health care reform. Section 6002 of the bill, the Physician Payment Sunshine Act, requires manufacturers of drugs, devices, biological therapeutics, and medical supplies to disclose to the Centers for Medicare and Medicaid Services any payments or transfers of value to physicians. These reports are not meant to prohibit relationships between physicians and industry, but rather to generate a searchable public database illustrating the purpose of the payment, the entities involved, and the timing of each occurrence. Although the bill is meant to reveal physician-industry relationships, the question of how society at large and the medical field will interpret these data are unknown. The purpose of this article is to inform physicians of the components of the Physician Payment Sunshine Act. We discuss several resultant challenges and suggest a framework for preparing for transparency reporting and its potential effects.

  15. Gut microbiota modulates adoptive cell therapy via CD8α dendritic cells and IL-12.

    PubMed

    Uribe-Herranz, Mireia; Bittinger, Kyle; Rafail, Stavros; Guedan, Sonia; Pierini, Stefano; Tanes, Ceylan; Ganetsky, Alex; Morgan, Mark A; Gill, Saar; Tanyi, Janos L; Bushman, Frederic D; June, Carl H; Facciabene, Andrea

    2018-02-22

    Adoptive T cell therapy (ACT) is a promising new modality for malignancies. Here, we report that adoptive T cell efficacy in tumor-bearing mice is significantly affected by differences in the native composition of the gut microbiome or treatment with antibiotics, or by heterologous fecal transfer. Depletion of bacteria with vancomycin decreased the rate of tumor growth in mice from The Jackson Laboratory receiving ACT, whereas treatment with neomycin and metronidazole had no effect, indicating the role of specific bacteria in host response. Vancomycin treatment induced an increase in systemic CD8α+ DCs, which sustained systemic adoptively transferred antitumor T cells in an IL-12-dependent manner. In subjects undergoing allogeneic hematopoietic cell transplantation, we found that oral vancomycin also increased IL-12 levels. Collectively, our findings demonstrate an important role played by the gut microbiota in the antitumor effectiveness of ACT and suggest potentially new avenues to improve response to ACT by altering the gut microbiota.

  16. Deployment of ACT antimalarials for treatment of malaria: challenges and opportunities

    PubMed Central

    Whitty, Christopher JM; Chandler, Clare; Ansah, Evelyn; Leslie, Toby; Staedke, Sarah G

    2008-01-01

    Following a long period when the effectiveness of existing mono-therapies for antimalarials was steadily declining with no clear alternative, most malaria-endemic countries in Africa and Asia have adopted artemisinin combination therapy (ACT) as antimalarial drug policy. Several ACT drugs exist and others are in the pipeline. If properly targeted, they have the potential to reduce mortality from malaria substantially. The major challenge now is to get the drugs to the right people. Current evidence suggests that most of those who need the drugs do not get them. Simultaneously, a high proportion of those who are given antimalarials do not in fact have malaria. Financial and other barriers mean that, in many settings, the majority of those with malaria, particularly the poorest, do not access formal healthcare, so the provision of free antimalarials via this route has only limited impact. The higher cost of ACT creates a market for fake drugs. Addressing these problems is now a priority. This review outlines current evidence, possible solutions and research priorities. PMID:19091041

  17. Analysis of Parent, Teacher, and Consultant Speech Exchanges and Educational Outcomes of Students With Autism During COMPASS Consultation.

    PubMed

    Ruble, Lisa; Birdwhistell, Jessie; Toland, Michael D; McGrew, John H

    2011-01-01

    The significant increase in the numbers of students with autism combined with the need for better trained teachers (National Research Council, 2001) call for research on the effectiveness of alternative methods, such as consultation, that have the potential to improve service delivery. Data from 2 randomized controlled single-blind trials indicate that an autism-specific consultation planning framework known as the collaborative model for promoting competence and success (COMPASS) is effective in increasing child Individual Education Programs (IEP) outcomes (Ruble, Dal-rymple, & McGrew, 2010; Ruble, McGrew, & Toland, 2011). In this study, we describe the verbal interactions, defined as speech acts and speech act exchanges that take place during COMPASS consultation, and examine the associations between speech exchanges and child outcomes. We applied the Psychosocial Processes Coding Scheme (Leaper, 1991) to code speech acts. Speech act exchanges were overwhelmingly affiliative, failed to show statistically significant relationships with child IEP outcomes and teacher adherence, but did correlate positively with IEP quality.

  18. Analysis of Parent, Teacher, and Consultant Speech Exchanges and Educational Outcomes of Students With Autism During COMPASS Consultation

    PubMed Central

    RUBLE, LISA; BIRDWHISTELL, JESSIE; TOLAND, MICHAEL D.; MCGREW, JOHN H.

    2011-01-01

    The significant increase in the numbers of students with autism combined with the need for better trained teachers (National Research Council, 2001) call for research on the effectiveness of alternative methods, such as consultation, that have the potential to improve service delivery. Data from 2 randomized controlled single-blind trials indicate that an autism-specific consultation planning framework known as the collaborative model for promoting competence and success (COMPASS) is effective in increasing child Individual Education Programs (IEP) outcomes (Ruble, Dal-rymple, & McGrew, 2010; Ruble, McGrew, & Toland, 2011). In this study, we describe the verbal interactions, defined as speech acts and speech act exchanges that take place during COMPASS consultation, and examine the associations between speech exchanges and child outcomes. We applied the Psychosocial Processes Coding Scheme (Leaper, 1991) to code speech acts. Speech act exchanges were overwhelmingly affiliative, failed to show statistically significant relationships with child IEP outcomes and teacher adherence, but did correlate positively with IEP quality. PMID:22639523

  19. Gut microbiota modulates adoptive cell therapy via CD8α dendritic cells and IL-12

    PubMed Central

    Bittinger, Kyle; Rafail, Stavros; Pierini, Stefano; Tanes, Ceylan; Ganetsky, Alex; Morgan, Mark A.; Gill, Saar; Tanyi, Janos L.; Bushman, Frederic D.; June, Carl H.

    2018-01-01

    Adoptive T cell therapy (ACT) is a promising new modality for malignancies. Here, we report that adoptive T cell efficacy in tumor-bearing mice is significantly affected by differences in the native composition of the gut microbiome or treatment with antibiotics, or by heterologous fecal transfer. Depletion of bacteria with vancomycin decreased the rate of tumor growth in mice from The Jackson Laboratory receiving ACT, whereas treatment with neomycin and metronidazole had no effect, indicating the role of specific bacteria in host response. Vancomycin treatment induced an increase in systemic CD8α+ DCs, which sustained systemic adoptively transferred antitumor T cells in an IL-12–dependent manner. In subjects undergoing allogeneic hematopoietic cell transplantation, we found that oral vancomycin also increased IL-12 levels. Collectively, our findings demonstrate an important role played by the gut microbiota in the antitumor effectiveness of ACT and suggest potentially new avenues to improve response to ACT by altering the gut microbiota. PMID:29467322

  20. Corticosteroid injection for the treatment of carpal tunnel syndrome

    PubMed Central

    O'Gradaigh, D; Merry, P

    2000-01-01

    OBJECTIVE—To compare low and high dose, and short and long acting corticosteroids in the treatment of carpal tunnel syndrome.
METHODS—A randomised, controlled, single blind trial with electromyographic and subjective outcome measures.
RESULTS—25 mg hydrocortisone is as effective as higher doses or long acting triamcinolone at a six week and six month follow up.
CONCLUSION—As low dose steroid is as effective, and potentially less toxic, this should be the recommended dose for injection of carpal tunnel syndrome.

 PMID:11053073

  1. The American Jobs Creation Act and its impact on deferred compensation: reassessment from a business perspective.

    PubMed

    Johnson, David G

    2005-01-01

    The American Jobs Creation Act (AJCA), which was signed into law in October 2004, will have an impact on almost every deferred compensation program in the United States. This article argues that as companies continue to evaluate the transition alternatives under AJCA and contemplate the necessary changes to the plan program, companies also should consider simultaneously addressing broader issues surrounding nonqualified deferred compensation arrangements. These include ongoing business purpose, financial planning considerations, education of participants, corporate governance considerations and the potential implications to international assignees.

  2. Assessing Pesticides under the Endangered Species Act

    EPA Pesticide Factsheets

    EPA’s pesticide risk assessment and regulatory processes ensure that protections are in place for all populations of non-target species. We have developed risk assessment procedures to determine potential for harm to individuals of a listed species.

  3. 29 CFR 2580.412-34 - General.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... section 502(a) of the Labor-Management Reporting and Disclosure Act of 1959 (73 Stat. 536; 29 U.S.C. 502(a)). The fundamental purpose of Congress under 13(c) is to insure against potential abuses arising from...

  4. FIFRA Peer Review: Proposed Risk Assessment Methods Process

    EPA Pesticide Factsheets

    From September 11-14, 2012, EPA participated in a Federal Insecticide, Fungicide and Rodenticide Act Scientific Advisory Panel (SAP) meeting on a proposed pollinator risk assessment framework for determining the potential risks of pesticides to honey bees.

  5. How to Manual: How to Update and Enhance Your Local Source Water Protection Assessments

    EPA Pesticide Factsheets

    Describes opportunities for improving source water assessments performed under the Safe Drinking Water Act 1453. It includes: local delineations, potential contaminant source inventories, and susceptibility determinations of source water assessment.

  6. Commission to Study the Potential Creation of a National Women's History Museum Act

    THOMAS, 113th Congress

    Sen. Collins, Susan M. [R-ME

    2013-02-27

    Senate - 12/10/2014 Placed on Senate Legislative Calendar under General Orders. Calendar No. 630. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  7. Reducing Hydrofluorocarbon (HFC) Use and Emissions in the Federal Sector through SNAP

    EPA Pesticide Factsheets

    Certain HFCs have high global-warming potential, raising concern about their impacts as they become increasingly used as replacements for ozone-depleting substances (ODS) being phased out under the Clean Air Act (CAA).

  8. An Evaluation of detectable warning surfaces for sidewalk curb ramps.

    DOT National Transportation Integrated Search

    1995-01-01

    The 1991 Americans with Disabilities Act Accessibility Guidelines required the installation of a detectable warning surface (raised truncated domes) on sidewalk curb ramps to alert visually impaired people to potential hazards. Although this requirem...

  9. A history of biological and chemical warfare and terrorism.

    PubMed

    Malloy, C D

    2000-07-01

    This article provides a brief history of biological warfare and terrorism. It contends that examining disease in history provides public health specialists with the knowledge necessary to improve our surveillance system for potential acts of bioterrorism.

  10. Legal dimensions of neural antecedents to voluntary action.

    PubMed

    Patterson, Dennis

    2014-01-01

    This article considers the arguments of Nachev and Hacker in the context of claims that Libet's experiments regarding the readiness potential pose challenges for the criminal law, specifically for the distinction between voluntary and involuntary acts.

  11. Identity transformation in medical students.

    PubMed

    Cohen, Mitchell J M; Kay, Abigail; Youakim, James M; Balaicuis, John M; Balacius, John M

    2009-03-01

    This paper reviews the literature on the impact of medical school on personal development and consolidation of core identity. The limited literature relies on reports from medical students' journaling exercises, discussion groups, post-graduation surveys, and repeated personality testing. We review forces acting on medical students, with potential transforming effects. These forces include high external expectations and internal fear of superficial knowledge and skills, entry into the culture of medicine with its insider jargon and hierarchy, high academic workload, and the emotional burdens of confronting cadavers and death as well as bearing witness to patients' suffering. Potential developmental delay, emergence of substance abuse and hedonic acting out, cynicism, and loss of individual core values are possible consequences. Protections against these adverse outcomes include identification of strong mentors and role models, developing post-conventional morality and relativistic thinking, finding healthy coping strategies such as peer support, and remaining intellectually creative and personally reflective.

  12. National Environmental Policy Act Hazards Assessment for the TREAT Alternative

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Boyd D. Christensen; Annette L. Schafer

    2013-11-01

    This document provides an assessment of hazards as required by the National Environmental Policy Act for the alternative of restarting the reactor at the Transient Reactor Test (TREAT) facility by the Resumption of Transient Testing Program. Potential hazards have been identified and screening level calculations have been conducted to provide estimates of unmitigated dose consequences that could be incurred through this alternative. Consequences considered include those related to use of the TREAT Reactor, experiment assembly handling, and combined events involving both the reactor and experiments. In addition, potential safety structures, systems, and components for processes associated with operating TREAT andmore » onsite handling of nuclear fuels and experiments are listed. If this alternative is selected, a safety basis will be prepared in accordance with 10 CFR 830, “Nuclear Safety Management,” Subpart B, “Safety Basis Requirements.”« less

  13. National Environmental Policy Act Hazards Assessment for the TREAT Alternative

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Christensen, Boyd D.; Schafer, Annette L.

    2014-02-01

    This document provides an assessment of hazards as required by the National Environmental Policy Act for the alternative of restarting the reactor at the Transient Reactor Test (TREAT) facility by the Resumption of Transient Testing Program. Potential hazards have been identified and screening level calculations have been conducted to provide estimates of unmitigated dose consequences that could be incurred through this alternative. Consequences considered include those related to use of the TREAT Reactor, experiment assembly handling, and combined events involving both the reactor and experiments. In addition, potential safety structures, systems, and components for processes associated with operating TREAT andmore » onsite handling of nuclear fuels and experiments are listed. If this alternative is selected, a safety basis will be prepared in accordance with 10 CFR 830, “Nuclear Safety Management,” Subpart B, “Safety Basis Requirements.”« less

  14. Methods proposed to achieve air quality standards for mobile sources and technology surveillance.

    PubMed Central

    Piver, W T

    1975-01-01

    The methods proposed to meet the 1975 Standards of the Clean Air Act for mobile sources are alternative antiknocks, exhaust emission control devices, and alternative engine designs. Technology surveillance analysis applied to this situation is an attempt to anticipate potential public and environmental health problems from these methods, before they happen. Components of this analysis are exhaust emission characterization, environmental transport and transformation, levels of public and environmental exposure, and the influence of economics on the selection of alternative methods. The purpose of this presentation is to show trends as a result of the interaction of these different components. In no manner can these trends be interpreted explicitly as to what will really happen. Such an analysis is necessary so that public and environmental health officials have the opportunity to act on potential problems before they become manifest. PMID:50944

  15. Contraceptive counseling among pediatric primary care providers in Western Pennsylvania: A survey-based study.

    PubMed

    Papas, Beth Ann; Shaikh, Nader; Watson, Katherine; Sucato, Gina S

    2017-01-01

    Data suggest that adolescents in the United States receive inadequate contraceptive counseling. This study sought to determine factors affecting pediatricians' discussion of contraception with adolescent patients, with a specific focus on long-acting reversible contraception-implantable contraception and intrauterine devices. A cross-sectional survey was sent via email to a convenience sample of pediatric residents and pediatric primary care providers in Western Pennsylvania. Self-reported contraceptive counseling and prescribing practices in response to clinical vignettes were assessed. Of potential participants (287), 88 (31%) responded. Younger providers and providers who had received contraceptive training were significantly more likely to discuss long-acting reversible contraception methods. Discussion of contraceptive methods also varied by both the age and the sexual history of the patient. Variation in contraceptive counseling potentially results in missed opportunities to counsel about and provide the most effective contraceptive methods. More uniform, universal provider training might alleviate some of these inconsistencies.

  16. Nanoporous carbon tunable resistor/transistor and methods of production thereof

    DOEpatents

    Biener, Juergen; Baumann, Theodore F; Dasgupta, Subho; Hahn, Horst

    2014-04-22

    In one embodiment, a tunable resistor/transistor includes a porous material that is electrically coupled between a source electrode and a drain electrode, wherein the porous material acts as an active channel, an electrolyte solution saturating the active channel, the electrolyte solution being adapted for altering an electrical resistance of the active channel based on an applied electrochemical potential, wherein the active channel comprises nanoporous carbon arranged in a three-dimensional structure. In another embodiment, a method for forming the tunable resistor/transistor includes forming a source electrode, forming a drain electrode, and forming a monolithic nanoporous carbon material that acts as an active channel and selectively couples the source electrode to the drain electrode electrically. In any embodiment, the electrolyte solution saturating the nanoporous carbon active channel is adapted for altering an electrical resistance of the nanoporous carbon active channel based on an applied electrochemical potential.

  17. Frequency spectrum might act as communication code between retina and visual cortex I

    PubMed Central

    Yang, Xu; Gong, Bo; Lu, Jian-Wei

    2015-01-01

    AIM To explore changes and possible communication relationship of local potential signals recorded simultaneously from retina and visual cortex I (V1). METHODS Fourteen C57BL/6J mice were measured with pattern electroretinogram (PERG) and pattern visually evoked potential (PVEP) and fast Fourier transform has been used to analyze the frequency components of those signals. RESULTS The amplitude of PERG and PVEP was measured at about 36.7 µV and 112.5 µV respectively and the dominant frequency of PERG and PVEP, however, stay unchanged and both signals do not have second, or otherwise, harmonic generation. CONCLUSION The results suggested that retina encodes visual information in the way of frequency spectrum and then transfers it to primary visual cortex. The primary visual cortex accepts and deciphers the input visual information coded from retina. Frequency spectrum may act as communication code between retina and V1. PMID:26682156

  18. Converging advances in science, policy and public awareness: A time of great opportunity and change in addiction treatment.

    PubMed

    Woodworth, Abigail Mason; McLellan, A Thomas

    2016-05-01

    Scientific advances, increased public awareness about addiction as a disease, and significant changes in public policy have led to transformational changes in this field. Preclinical and clinical studies highlighted in this issue have supported the emerging concept of substance use disorders as a novel major concern within the healthcare community. In this Commentary, we discuss the potential impact of recent legislation (Affordable Care Act and the Mental Health Parity and Addiction Equity Act) when fully implemented to end the real and perceived segregation of addiction and substance abuse disorders from mainstream healthcare and insurance reimbursement. These legislative changes, along with the diligence of public interest and scientific advances, have the potential to move prevention and treatment of substance use disorders to mainstream healthcare, and to educate professionals appropriately on the prevention and treatment of substance abuse. Copyright © 2016. Published by Elsevier Inc.

  19. Impact of the Health Insurance Portability and Accountability Act on participant recruitment and retention.

    PubMed

    Wipke-Tevis, Deidre D; Pickett, Melissa A

    2008-02-01

    Recruiting and retaining an adequate sample is critical to the success of any research project involving humans. Recent reports indicate that the Health Insurance Portability and Accountability Act (HIPAA) privacy rule has adversely affected research. Few resources are available to help researchers navigate the challenges to recruitment and retention after HIPAA privacy rule implementation. This article addresses obstacles to recruitment in prospective clinical research studies related to the HIPAA privacy rule, as well as HIPAA-compliant strategies to enhance recruitment and retention. Recruitment challenges discussed include evolving interpretations of the HIPAA regulations, inability to directly contact potential participants, complexity of HIPAA-required documents, increased costs of recruitment, and an expanding administrative burden. Among the strategies addressed are preparatory research reviews, using clinical collaborators and staff liaisons, prescreening potential participants, minimizing participant burden during the consent process, enhancing participant follow-up, facilitating recruitment for future studies, and streamlining compliance training for staff.

  20. Chapter 3. Responses of Freshwater Fish to Temperature ...

    EPA Pesticide Factsheets

    Scientists at the NHEERL, and its predecessor—the Office of Environmental Processes and Effects Research—initiated research in 1988 anticipating the Global Change Research Act. The purpose of this document is to summarize ecological research conducted by NHEERL scientists under the EPA’s contribution to the USGCRP from the onset of research through approximately 2002. The intent is to provide that information as reference material for scientists investigating the potential impacts of climate change on ecosystems Scientists at the NHEERL, and its predecessor—the Office of Environmental Processes and Effects Research—initiated research in 1988 anticipating the Global Change Research Act. The purpose of this document is to summarize ecological research conducted by NHEERL scientists under the EPA’s contribution to the USGCRP from the onset of research through approximately 2002. The intent is to provide that information as reference material for scientists investigating the potential impacts of climate change on ecosystems

  1. Frequency spectrum might act as communication code between retina and visual cortex I.

    PubMed

    Yang, Xu; Gong, Bo; Lu, Jian-Wei

    2015-01-01

    To explore changes and possible communication relationship of local potential signals recorded simultaneously from retina and visual cortex I (V1). Fourteen C57BL/6J mice were measured with pattern electroretinogram (PERG) and pattern visually evoked potential (PVEP) and fast Fourier transform has been used to analyze the frequency components of those signals. The amplitude of PERG and PVEP was measured at about 36.7 µV and 112.5 µV respectively and the dominant frequency of PERG and PVEP, however, stay unchanged and both signals do not have second, or otherwise, harmonic generation. The results suggested that retina encodes visual information in the way of frequency spectrum and then transfers it to primary visual cortex. The primary visual cortex accepts and deciphers the input visual information coded from retina. Frequency spectrum may act as communication code between retina and V1.

  2. Nanobiotechnology for hemoglobin-based blood substitutes.

    PubMed

    Chang, T M S

    2009-04-01

    Nanobiotechnology is the assembling of biological molecules into nanodimension complexes. This has been used for the preparation of polyhemoglobin formed by the assembling of hemoglobin molecules into a soluble nanodimension complex. New generations of this approach include the nanobiotechnological assembly of hemoglobin, catalase, and superoxide dismutase into a soluble nanodimension complex. This acts as an oxygen carrier and an antioxidant for those conditions with potential for ischemiareperfusion injuries. Another recent novel approach is the assembling of hemoglobin and fibrinogen into a soluble nanodimension polyhemoglobin-fibrinogen complex that acts as an oxygen carrier with platelet-like activity. This is potentially useful in cases of extensive blood loss requiring massive replacement using blood substitutes, resulting in the need for the replacement of platelets and clotting factors. A further step is the preparation of nanodimension artificial red blood cells that contain hemoglobin and all the enzymes present in red blood cells.

  3. Antibody-mediated delivery of therapeutics for cancer therapy.

    PubMed

    Parakh, Sagun; Parslow, Adam C; Gan, Hui K; Scott, Andrew M

    2016-01-01

    Antibody-conjugated therapies (ACTs) combine the specificity of monoclonal antibodies to target cancer cells directly with highly potent payloads, often resulting in superior efficacy and/or reduced toxicity. This represents a new approach to the treatment of cancer. There have been highly promising clinical trial results using this approach with improvements in linker and payload technology. The breadth of current trials examining ACTs in haematological malignancies and solid tumours indicate the potential for clinical impact. This review will provide an overview of ACTs currently in clinical development as well as the principles of antibody delivery and types of payloads used, including cytotoxic drugs, radiolabelled isotopes, nanoparticle-based siRNA particles and immunotoxins. The focus of much of the clinical activity in ACTs has, understandably, been on their use as a monotherapy or in combination with standard of care drugs. This will continue, as will the search for better targets, linkers and payloads. Increasingly, as these drugs enter routine clinical care, important questions will arise regarding how to optimise ACT treatment approaches, including investigation of resistance mechanisms, biomarker and patient selection strategies, understanding of the unique toxicities of these drugs, and combinatorial approaches with standard therapies as well as emerging therapeutic agents like immunotherapy.

  4. A new electrochemical sensor for the simultaneous determination of acetaminophen and codeine based on porous silicon/palladium nanostructure.

    PubMed

    Ensafi, Ali A; Ahmadi, Najmeh; Rezaei, Behzad; Abarghoui, Mehdi Mokhtari

    2015-03-01

    A porous silicon/palladium nanostructure was prepared and used as a new electrode material for the simultaneous determination of acetaminophen (ACT) and codeine (COD). Palladium nanoparticles were assembled on porous silicon (PSi) microparticles by a simple redox reaction between the Pd precursor and PSi in an aqueous solution of hydrofluoric acid. This novel nanostructure was characterized by different spectroscopic and electrochemical techniques including scanning electron microscopy, X-ray diffraction, energy dispersive X-ray spectroscopy, fourier transform infrared spectroscopy and cyclic voltammetry. The high electrochemical activity, fast electron transfer rate, high surface area and good antifouling properties of this nanostructure enhanced the oxidation peak currents and reduced the peak potentials of ACT and COD at the surface of the proposed sensor. Simultaneous determination of ACT and COD was explored using differential pulse voltammetry. A linear range of 1.0-700.0 µmol L(-1) was achieved for ACT and COD with detection limits of 0.4 and 0.3 µmol L(-1), respectively. Finally, the proposed method was used for the determination of ACT and COD in blood serum, urine and pharmaceutical compounds. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. The potential of legislation on organ donation to increase the supply of donor organs.

    PubMed

    Coppen, Remco; Friele, Roland D; van der Zee, Jouke; Gevers, Sjef K

    2010-12-01

    The aim of this paper is to assess the possibilities to adapt the 1998 Dutch Organ Donation Act, taking account of fundamental principles such as the right to physical integrity, equitable access to and equal availability of care, and the non-commerciality principle, with a view to increasing the organ supply. In 2008 the Dutch Taskforce on Organ Donation presented several proposals to amend the Act and to increase the supply of organs. This paper describes the proposals to amend the Act and evaluates them by assessing their intrinsic adherence to basic principles and the available evidence that these proposals will indeed increase the organ supply. Several proposals could constitute an infringement of fundamental principles of the Act. Moreover, evidence for their impact on the organ supply is lacking. Changing the consent system is possible, as this would not incur legal objections. There are diverging views regarding the impact of consent systems on the organ supply. The scope for changing the Act and its impact on organ procurement is at best limited. Relying on legislation alone will possibly not bring much relief, whereas additional policy measures may be more successful. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  6. Recombinant α-actinin subunit antigens of Trichomonas vaginalis as potential vaccine candidates in protecting against trichomoniasis.

    PubMed

    Xie, Yi-Ting; Gao, Jiang-Mei; Wu, Ya-Ping; Tang, Petrus; Hide, Geoff; Lai, De-Hua; Lun, Zhao-Rong

    2017-02-16

    Human trichomoniasis caused by Trichomonas vaginalis is one of the most common sexually transmitted diseases with more than 200 million cases worldwide. It has caused a series of health problems to patients. For prevention and control of infectious diseases, vaccines are usually considered as one of the most cost-efficient tools. However, until now, work on the development of T. vaginalis vaccines is still mainly focused on the screening of potential immunogens. Alpha-actinin characterized by high immunogenicity in T. vaginalis was suggested as a promising candidate. Therefore, the purpose of this study was to evaluate the protective potency of recombinant α-actinin against T. vaginalis infection in a mouse intraperitoneal model. Two selected coding regions of α-actinin (ACT-F, 14-469 aa and ACT-T, 462-844 aa) amplified from cDNA were cloned into pET-32a (+) expression vector and transfected into BL21 cells. After induction with IPTG and purification with electroelution, the two recombinant fusion proteins were emulsified in Freund's adjuvant (FA) and used to immunize BALB/C mice. Following intraperitoneal inoculation with T. vaginalis, the survival rate of mice was monitored for the assessment of protective potency. After immunization, the antibody level in mouse serum was assessed by ELISA, splenocyte proliferation response was detected with CCK8 and cytokines in the supernatant of splenocytes were quantified with a cytometric bead-based assay. We successfully obtained purified ACT-F (70.33 kDa) and ACT-T (61.7kDa). Both recombinant proteins could provide significant protection against T. vaginalis challenge, especially ACT-T (with 100% protection within one month). Meanwhile, high levels of specific total IgG and subtypes (IgG1 > IgG2a) were detected in sera from the immunized mice. Our results also revealed a statistically significant increase in splenocyte proliferation and related cytokine (IFN-γ, IL-6, IL-17A and IL-10) production after repeated stimulation with the corresponding antigens in vitro. Immunization with both ACT-F and ACT-T could confer partial to complete protection and trigger strong Th1/Th2 mixed humoral and cellular immune responses in the mouse host. This suggested that recombinant α-actinin subunit antigens may be promising vaccine candidates against trichomoniasis.

  7. Phytoextraction of toxic trace elements by Sorghum bicolor inoculated with Streptomyces pactum (Act12) in contaminated soils.

    PubMed

    Ali, Amjad; Guo, Di; Mahar, Amanullah; Wang, Ping; Ma, Fang; Shen, Feng; Li, Ronghua; Zhang, Zengqiang

    2017-05-01

    The increasing industrial, mining and agricultural activities have intensified the release of potential toxic trace elements (PTEs), which are of great concern to human health and environment. The alarming increase in PTEs concentration, stress the need for biotechnological remediation approaches. In order to assist phytoextraction of PTEs, different combinations of Streptomyces pactum (Act12) with biochar were applied to mining and industrial polluted soils of Shaanxi and Hunan Provinces of China, respectively. Act12 affected soil physico-chemical properties in both soils. Bioavailable Zn and Pb increased due to microbial activities, while Cd decreased by adsorption on biochar surface. Phytoextraction of Zn and Pb occurred in TG and CZ soil, while Cd uptake decreased in iron rich CZ soil by conflicting effect of siderophores. Cd in sorghum shoot was below detection level, but uptake increased in the roots due to minimum available fraction in TG soil. Biochar reduced the shoot and root uptake of Cd. Sorghum shoot, root dry weight and chlorophyll significantly increased after Act12 and biochar application. β-glucosidase, alkaline phosphatase and urease activities were significantly enhanced by Act12. Antioxidant enzymatic activities (POD, PAL and PPO) and lipid peroxidation (MDA) were decreased after the application of Act12 and biochar by reduced PTEs stress. Act12 and biochar can be used for different crops to enumerate the transfer rate of PTEs into the food chain. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Assessing reported condom use among female sex workers in southern India through examination of condom availability.

    PubMed

    Bradley, Janet; Moses, Stephen; Blanchard, James F; Rajaram, S; Ramesh, B M; Verma, Supriya; Alary, Michel

    2010-02-01

    A key indicator of success of HIV prevention programmes is the number of female sex worker (FSW) sex acts protected by condoms. This measure usually relies on FSW reports, which may be biased. We examined condom availability data in five Karnataka districts to estimate the proportion of FSW sex acts potentially protected by condoms. Financial, programme, population, condom and contraceptive data were obtained from governmental and non-governmental sources, surveys and HIV prevention programmes. Sexual behaviour data were obtained from general population and FSW surveys. We examined four scenarios in a sensitivity analysis, each one assuming different proportions of available condoms that might have been used by sex workers. Possible condom use rates for all FSW sex acts ranged from 3%-36% in 2004 to 56%-96% in 2008. The two most realistic scenarios that discounted the number of private sector condoms that might have been bought for sex acts other than with FSWs showed that 16-24% of FSW sex acts could have been protected by condoms in 2004 rising to 77-85% in 2008. These data suggest that condom availability in these Karnataka districts in 2004 was low in relation to the number of FSW sex acts, but rose substantially over the ensuing 4 years. Condom availability data can be useful for triangulation with other available data, such as self-reported condom use, to provide a range of possibilities regarding the number of FSW sex acts protected by condoms.

  9. Cost-Utility of a Prognostic Test Guiding Adjuvant Chemotherapy Decisions in Early-Stage Non-Small Cell Lung Cancer.

    PubMed

    Stenehjem, David D; Bellows, Brandon K; Yager, Kraig M; Jones, Joshua; Kaldate, Rajesh; Siebert, Uwe; Brixner, Diana I

    2016-02-01

    A prognostic test was developed to guide adjuvant chemotherapy (ACT) decisions in early-stage non-small cell lung cancer (NSCLC) adenocarcinomas. The objective of this study was to compare the cost-utility of the prognostic test to the current standard of care (SoC) in patients with early-stage NSCLC. Lifetime costs (2014 U.S. dollars) and effectiveness (quality-adjusted life-years [QALYs]) of ACT treatment decisions were examined using a Markov microsimulation model from a U.S. third-party payer perspective. Cancer stage distribution and probability of receiving ACT with the SoC were based on data from an academic cancer center. The probability of receiving ACT with the prognostic test was estimated from a physician survey. Risk classification was based on the 5-year predicted NSCLC-related mortality. Treatment benefit with ACT was based on the prognostic score. Discounting at a 3% annual rate was applied to costs and QALYs. Deterministic one-way and probabilistic sensitivity analyses examined parameter uncertainty. Lifetime costs and effectiveness were $137,403 and 5.45 QALYs with the prognostic test and $127,359 and 5.17 QALYs with the SoC. The resulting incremental cost-effectiveness ratio for the prognostic test versus the SoC was $35,867/QALY gained. One-way sensitivity analyses indicated the model was most sensitive to the utility of patients without recurrence after ACT and the ACT treatment benefit. Probabilistic sensitivity analysis indicated the prognostic test was cost-effective in 65.5% of simulations at a willingness to pay of $50,000/QALY. The study suggests using a prognostic test to guide ACT decisions in early-stage NSCLC is potentially cost-effective compared with using the SoC based on globally accepted willingness-to-pay thresholds. Providing prognostic information to decision makers may help some patients with high-risk early stage non-small cell lung cancer receive appropriate adjuvant chemotherapy while avoiding the associated toxicities and costs in patients with low-risk disease. This study used an economic model to assess the effectiveness and costs associated with using a prognostic test to guide adjuvant chemotherapy decisions compared with the current standard of care in patients with non-small cell lung cancer. When compared with current standard care, the prognostic test was potentially cost effective at commonly accepted thresholds in the U.S. This study can be used to help inform decision makers who are considering using prognostic tests. ©AlphaMed Press.

  10. The malaria testing and treatment landscape in Benin.

    PubMed

    Zinsou, Cyprien; Cherifath, Adjibabi Bello

    2017-04-26

    Since 2004, artemisinin-based combination therapy (ACT) has been the first-line treatment for uncomplicated malaria in Benin. In 2016, a medicine outlet survey was implemented to investigate the availability, price, and market share of anti-malarial treatment and malaria diagnostics. Results provide a timely and important benchmark to measure future interventions aimed at increasing access to quality malaria case management services. Between July 5th to August 6th 2016, a cross sectional, nationally-representative malaria outlet survey was conducted in Benin. A census of all public and private outlets with potential to distribute malaria testing and/or treatment was implemented among 30 clusters (arrondissements). Outlets were eligible for inclusion in the study if they met at least one of three study criteria: (1) one or more anti-malarials reportedly in stock on the day of the survey; (2) one or more anti-malarials reportedly in stock within the 3 months preceding the survey; and/or (3) provided malaria blood testing. An audit was completed for all anti-malarials, malaria rapid diagnostic tests (RDT) and microscopy. 7260 outlets with the potential to sell or distribute anti-malarials were included in the census and 2966 were eligible and interviewed. A total of 17,669 anti-malarial and 494 RDT products were audited. Quality-assured ACT was available in 95.0% of all screened public health facilities and 59.4% of community health workers (CHW), and availability of malaria blood testing was 94.7 and 68.4% respectively. Sulfadoxine-pyrimethamine (SP) was available in 73.9% of public health facilities and not found among CHWs. Among private-sector outlets stocking at least one anti-malarial, non-artemisinin therapies were most commonly available (94.0% of outlets) as compared to quality-assured ACT (36.1%). 31.3% of the ACTs were marked with a "green leaf" logo, suggesting leakage of a co-paid ACT into Benin's unsubsidized ACT market from another country. 78.5% of the anti-malarials distributed were through the private sector, typically through general retailers (47.6% of all anti-malarial distribution). ACT comprised 44% of the private anti-malarial market share. Private-sector price of quality-assured ACT ($1.35) was three times more expensive than SP ($0.42) or chloroquine ($0.41). Non-artemisinin therapies were cited as the most effective treatment for uncomplicated malaria among general retailers and itinerant drug vendors. The ACTwatch data has shown the importance of the private sector in terms of access to malaria treatment for the majority of the population in Benin. These findings highlight the need for increased engagement with the private sector to improve malaria case management and an immediate need for a national ACT subsidy.

  11. Health insurance exchanges bring potential opportunities.

    PubMed

    Jacobs, M Orry; Eggbeer, Bill

    2012-11-01

    The introduction of the state health insurance exchanges, as provided for in the Affordable Care Act, has many strategic implications for healthcare providers: Unprecedented transparency; The "Walmart Effect", with patients playing a greater role as healthcare consumers; A rise in narrow networks spurred by low prices and narrow geographies; The potential end of the cross subsidy of Medicare and Medicaid by commercial plans; The possible end of not-for-profit status for hospitals

  12. The retrodural space of Okada.

    PubMed

    Murthy, Naveen S; Maus, Timothy P; Aprill, Charles

    2011-06-01

    The retrodural space of Okada is a potential space that can act as a conduit for the spread of inflammatory or infectious processes, connecting ipsilateral adjacent facet joints, contralateral adjacent facet joints, adjacent neural foramen, paraspinal musculature, and spinous process adventitial bursa (i.e., Baastrup disease). Awareness of these potential retrodural communications during diagnostic imaging interpretation and interventional spine injection procedures can play an important role in patient care and management.

  13. Maximizing DOD’s Untapped Potential to Improve Business Performance

    DTIC Science & Technology

    2009-10-14

    Maximizing DOD’s Untapped Potential to Improve Business Performance DOD Performance Breakthrough Convention Lansdowne, VA October 14, 2009...Gene L. Dodaro, Acting Comptroller General of the United States It is a pleasure to be here today to discuss business operations at the...I recognize that business practices at DOD are not going to change overnight. But this conference can help this process by encouraging an exchange

  14. An analysis of candidates for addition to the Clean Air Act list of hazardous air pollutants.

    PubMed

    Lunder, Sonya; Woodruff, Tracey J; Axelrad, Daniel A

    2004-02-01

    There are 188 air toxics listed as hazardous air pollutants (HAPs) in the Clean Air Act (CAA), based on their potential to adversely impact public health. This paper presents several analyses performed to screen potential candidates for addition to the HAPs list. We analyzed 1086 HAPs and potential HAPs, including chemicals regulated by the state of California or with emissions reported to the Toxics Release Inventory (TRI). HAPs and potential HAPs were ranked by their emissions to air, and by toxicity-weighted (tox-wtd) emissions for cancer and noncancer, using emissions information from the TRI and toxicity information from state and federal agencies. Separate consideration was given for persistent, bioaccumulative toxins (PBTs), reproductive or developmental toxins, and chemicals under evaluation for regulation as toxic air contaminants in California. Forty-four pollutants were identified as candidate HAPs based on three ranking analyses and whether they were a PBT or a reproductive or developmental toxin. Of these, nine qualified in two or three different rankings (ammonia [NH3], copper [Cu], Cu compounds, nitric acid [HNO3], N-methyl-2-pyrrolidone, sulfuric acid [H2SO4], vanadium [V] compounds, zinc [Zn], and Zn compounds). This analysis suggests further evaluation of several pollutants for possible addition to the CAA list of HAPs.

  15. Air pollution, inflammation and preterm birth: a potential mechanistic link.

    PubMed

    Vadillo-Ortega, Felipe; Osornio-Vargas, Alvaro; Buxton, Miatta A; Sánchez, Brisa N; Rojas-Bracho, Leonora; Viveros-Alcaráz, Martin; Castillo-Castrejón, Marisol; Beltrán-Montoya, Jorge; Brown, Daniel G; O'Neill, Marie S

    2014-02-01

    Preterm birth is a public health issue of global significance, which may result in mortality during the perinatal period or may lead to major health and financial consequences due to lifelong impacts. Even though several risk factors for preterm birth have been identified, prevention efforts have failed to halt the increasing rates of preterm birth. Epidemiological studies have identified air pollution as an emerging potential risk factor for preterm birth. However, many studies were limited by study design and inadequate exposure assessment. Due to the ubiquitous nature of ambient air pollution and the potential public health significance of any role in causing preterm birth, a novel focus investigating possible causal mechanisms influenced by air pollution is therefore a global health priority. We hypothesize that air pollution may act together with other biological factors to induce systemic inflammation and influence the duration of pregnancy. Evaluation and testing of this hypothesis is currently being conducted in a prospective cohort study in Mexico City and will provide an understanding of the pathways that mediate the effects of air pollution on preterm birth. The important public health implication is that crucial steps in this mechanistic pathway can potentially be acted on early in pregnancy to reduce the risk of preterm birth. Copyright © 2013 Elsevier Ltd. All rights reserved.

  16. AIR POLLUTION, INFLAMMATION AND PRETERM BIRTH: A POTENTIAL MECHANISTIC LINK

    PubMed Central

    Vadillo-Ortega, Felipe; Osornio-Vargas, Alvaro; Buxton, Miatta A.; Sánchez, Brisa N.; Rojas-Bracho, Leonora; Viveros-Alcaráz, Martin; Castillo-Castrejón, Marisol; Beltrán-Montoya, Jorge; Brown, Daniel G.; O´Neill, Marie S.

    2014-01-01

    Preterm birth is a public health issue of global significance, which may result in mortality during the perinatal period or may lead to major health and financial consequences due to lifelong impacts. Even though several risk factors for preterm birth have been identified, prevention efforts have failed to halt the increasing rates of preterm birth. Epidemiological studies have identified air pollution as an emerging potential risk factor for preterm birth. However, many studies were limited by study design and inadequate exposure assessment. Due to the ubiquitous nature of ambient air pollution and the potential public health significance of any role in causing preterm birth, a novel focus investigating possible causal mechanisms influenced by air pollution is therefore a global health priority. We hypothesize that air pollution may act together with other biological factors to induce systemic inflammation and influence the duration of pregnancy. Evaluation and testing of this hypothesis is currently being conducted in a prospective cohort study in Mexico City and will provide an understanding of the pathways that mediate the effects of air pollution on preterm birth. The important public health implication is that crucial steps in this mechanistic pathway can potentially be acted on early in pregnancy to reduce the risk of preterm birth. PMID:24382337

  17. Lincomycin at Subinhibitory Concentrations Potentiates Secondary Metabolite Production by Streptomyces spp.

    PubMed

    Imai, Yu; Sato, Seizo; Tanaka, Yukinori; Ochi, Kozo; Hosaka, Takeshi

    2015-06-01

    Antibiotics have either bactericidal or bacteriostatic activity. However, they also induce considerable gene expression in bacteria when used at subinhibitory concentrations (below the MIC). We found that lincomycin, which inhibits protein synthesis by binding to the ribosomes of Gram-positive bacteria, was effective for inducing the expression of genes involved in secondary metabolism in Streptomyces strains when added to medium at subinhibitory concentrations. In Streptomyces coelicolor A3(2), lincomycin at 1/10 of its MIC markedly increased the expression of the pathway-specific regulatory gene actII-ORF4 in the blue-pigmented antibiotic actinorhodin (ACT) biosynthetic gene cluster, which resulted in ACT overproduction. Intriguingly, S. lividans 1326 grown in the presence of lincomycin at a subinhibitory concentration (1/12 or 1/3 of its MIC) produced abundant antibacterial compounds that were not detected in cells grown in lincomycin-free medium. Bioassay and mass spectrometry analysis revealed that some antibacterial compounds were novel congeners of calcium-dependent antibiotics. Our results indicate that lincomycin at subinhibitory concentrations potentiates the production of secondary metabolites in Streptomyces strains and suggest that activating these strains by utilizing the dose-response effects of lincomycin could be used to effectively induce the production of cryptic secondary metabolites. In addition to these findings, we also report that lincomycin used at concentrations for markedly increased ACT production resulted in alteration of the cytoplasmic protein (FoF1 ATP synthase α and β subunits, etc.) profile and increased intracellular ATP levels. A fundamental mechanism for these unique phenomena is also discussed. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  18. Moving from the HIV Organ Policy Equity Act to HIV Organ Policy Equity in action: changing practice and challenging stigma.

    PubMed

    Doby, Brianna L; Tobian, Aaron A R; Segev, Dorry L; Durand, Christine M

    2018-04-01

    The HIV Organ Policy Equity (HOPE) Act, signed in 2013, reversed the federal ban on HIV-to-HIV transplantation. In this review, we examine the progress in HOPE implementation, the current status of HIV-to-HIV transplantation, and remaining challenges. Pursuant to the HOPE Act, the Department of Health and Human Services revised federal regulations to allow HIV-to-HIV transplants under research protocols adherent to criteria published by the National Institutes of Health. The first HIV-to-HIV kidney and liver transplants were performed at Johns Hopkins in March of 2016. Legal and practical challenges remain. Further efforts are needed to educate potential HIV+ donors and to support Organ Procurement Organizations. As of November 2017, there are 22 transplant centers approved to perform HIV-to-HIV transplants in 10 United Network for Organ Sharing regions. To date, 16 Organ Procurement Organizations in 22 states have evaluated HIV+ donors. The National Institutes of Health-funded HOPE in Action: A Multicenter Clinical Trial of HIV-to-HIV Deceased Donor (HIVDD) Kidney Transplantation Kidney Trial will launch at 19 transplant centers in December of 2017. A HOPE in Action Multicenter HIVDD Liver Trial is in development. Significant progress toward full HOPE implementation has been made though barriers remain. Some challenges are unique to HIV-HIV transplantation, whereas others are amplifications of issues across the current transplant system. In addition to a public health benefit for all transplant candidates in the United States, partnership on the HOPE Act has the potential to address systemic challenges to national donation and transplantation.

  19. THE INTEGRATION OF THE 241-Z BUILDING DECONTAMINATION & DECOMMISSIONING (D&D) UNDER COMPREHENSIVE ENVIRONMENTAL RESPONSE COMPENSATION & LIABILITY ACT (CERCLA) WITH RESOURCE CONSERVATION & RECOVERY ACT (RCRA) CLOSURE AT THE PLUTONIUM FINISHING PLANT (PFP)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    HOPKINS, A.M.

    2007-02-20

    The 241-Z treatment and storage tanks, a hazardous waste Treatment, Storage and Disposal (TSD) unit permitted pursuant to the ''Resource Conservation and Recovery Act of 1976'' (RCRA) and Washington State ''Hazardous Waste Management Act, RCW 70.105'', have been deactivated and are being actively decommissioned. The 241-Z TSD unit managed non-listed radioactive contaminated waste water, containing trace RCRA characteristic constituents. The 241-Z TSD unit consists of below grade tanks (D-4, D-5, D-7, D-8, and an overflow tank) located in a concrete containment vault, sample glovebox GB-2-241-ZA, and associated ancillary piping and equipment. The tank system is located beneath the 241-Z building.more » The 241-Z building is not a portion of the TSD unit. The sample glovebox is housed in the above-grade building. Waste managed at the TSD unit was received via underground mining from Plutonium Finishing Plant (PFP) sources. Tank D-6, located in the D-6 vault cell, is a past-practice tank that was taken out of service in 1972 and has never operated as a portion of the RCRA TSD unit. CERCLA actions address Tank D-6, its containment vault cell, and soil beneath the cell that was potentially contaminated during past-practice operations and any other potential past-practice contamination identified during 241-Z closure, while outside the scope of the ''Hanford Facility Dangerous Waste Closure Plant, 241-Z Treatment and Storage Tanks''.« less

  20. 78 FR 22260 - Information Collection Being Submitted to the Office of Management and Budget for Review and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ... Act Impact Assessment: N/A. Nature and Extent of Confidentiality: No information is requested that... manufacturers and the public. The coordinator will also notify users of potential frequency conflicts. Federal...

  1. 78 FR 61349 - Information Collection Being Submitted for Review and Approval to the Office of Management and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-03

    .... Total Annual Cost: $462,600. Privacy Act Impact Assessment: N/A. Nature and Extent of Confidentiality... public. The coordinator will also notify users of potential frequency conflicts. Federal Communications...

  2. Information about the Catalog of Federal Domestic Assistance and EPA Programs

    EPA Pesticide Factsheets

    The primary purpose of the Catalog is to assist potential applicants in identifying programs which meet their specific objectives & to provide general information on Federal assistance programs. In 1977 Congress passed the Federal Program Information Act.

  3. Chemical Safety Research Advances in Support of Lautenberg Act

    EPA Pesticide Factsheets

    EPA researchers are developing new ways to identify which chemicals to prioritize for further testing, to provide better access to information about chemicals, and to understand what potential risks chemicals may pose to humans and the environment.

  4. 78 FR 32474 - Agency Information Collection Activities: Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-30

    ...; Programs to strengthen scientific and engineering research potential; Science and engineering education... support applied research was added to the Organic Act. In 1980, The Science and Engineering Equal... NATIONAL SCIENCE FOUNDATION Agency Information Collection Activities: Comment Request AGENCY...

  5. 77 FR 31401 - Agency Information Collection Activities: Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-25

    ...; Programs to strengthen scientific and engineering research potential; Science and engineering education... support applied research was added to the Organic Act. In 1980, The Science and Engineering Equal... NATIONAL SCIENCE FOUNDATION Agency Information Collection Activities: Comment Request AGENCY...

  6. HUMAN EXPOSURE MEASUREMENTS - CHILDREN'S FOCUS

    EPA Science Inventory

    In support of the Food Quality Protection Act of 1996, research under this task is designed to identify those pesticides, pathways, and activities that represent the highest potential exposures to children and to determine the factors that influence these exposures. The research...

  7. 42 CFR 90.5 - Acting on requests.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES ADMINISTRATIVE FUNCTIONS, PRACTICES, AND... potential for further human exposure; (4) The recommendations of other governmental agencies; and (5) The... health assessments and health effects studies. (b) Where appropriate, ATSDR will request information from...

  8. 42 CFR 90.5 - Acting on requests.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES ADMINISTRATIVE FUNCTIONS, PRACTICES, AND... potential for further human exposure; (4) The recommendations of other governmental agencies; and (5) The... health assessments and health effects studies. (b) Where appropriate, ATSDR will request information from...

  9. Time for Transformation: Public Policy Must Change to Achieve Health Equity for LGBT Older Adults

    PubMed Central

    Fredriksen-Goldsen, Karen I.; Espinoza, Robert

    2015-01-01

    The marriage equality movement and the Affordable Care Act have enormous potential to reduce health disparities in LGBT elders, but more data and additional policy changes are sorely needed. PMID:25960600

  10. GAS AND BUBBLE PRODUCTION BY SIPHONOPHORES.

    DTIC Science & Technology

    Gas-filled siphonophore floats collected from a deep scattering layer (DSL) were photographed in the act of voluntarily expelling bubbles of nearly...Such free bubbles, together with the siphonophore floats themselves, constitute a biological family of potentially resonant sonar targets

  11. The Synthesis of Beta-Peptides Containing Guanidino Groups

    NASA Technical Reports Server (NTRS)

    Wen, Ke; Han, Hyunsoo; Hoffman, Timothy Z.; Janda, Kim D.; Orgel, Leslie E.

    2003-01-01

    The synthesis of the beta-peptide 1 by the postsynthetic modification of the corresponding amino-containing peptide 3 is described. The potential of 1 to act as a template for the ligation of complementary negatively-charged peptides is discussed.

  12. Mindfulness Facets, Social Anxiety, and Drinking to Cope with Social Anxiety: Testing Mediators of Drinking Problems.

    PubMed

    Clerkin, Elise M; Sarfan, Laurel D; Parsons, E Marie; Magee, Joshua C

    2017-02-01

    This cross-sectional study tested social anxiety symptoms, trait mindfulness, and drinking to cope with social anxiety as potential predictors and/or serial mediators of drinking problems. A community-based sample of individuals with co-occurring social anxiety symptoms and alcohol dependence were recruited. Participants ( N = 105) completed measures of social anxiety, drinking to cope with social anxiety, and alcohol use and problems. As well, participants completed the Five Facet Mindfulness Questionnaire , which assesses mindfulness facets of accepting without judgment, acting with awareness, not reacting to one's internal experiences, observing and attending to experiences, and labeling and describing. As predicted, the relationship between social anxiety symptoms and drinking problems was mediated by social anxiety coping motives across each of the models. Further, the relationship between specific mindfulness facets (acting with awareness, accepting without judgment, and describe) and drinking problems was serially mediated by social anxiety symptoms and drinking to cope with social anxiety. This research builds upon existing studies that have largely been conducted with college students to evaluate potential mediators driving drinking problems. Specifically, individuals who are less able to act with awareness, accept without judgment, and describe their internal experiences may experience heightened social anxiety and drinking to cope with that anxiety, which could ultimately result in greater alcohol-related problems.

  13. In Vitro Activities of Primaquine-Schizonticide Combinations on Asexual Blood Stages and Gametocytes of Plasmodium falciparum.

    PubMed

    Cabrera, Mynthia; Cui, Liwang

    2015-12-01

    Currently, the World Health Organization recommends addition of a 0.25-mg base/kg single dose of primaquine (PQ) to artemisinin combination therapies (ACTs) for Plasmodium falciparum malaria as a gametocytocidal agent for reducing transmission. Here, we investigated the potential interactions of PQ with the long-lasting components of the ACT drugs for eliminating the asexual blood stages and gametocytes of in vitro-cultured P. falciparum strains. Using the SYBR green I assay for asexual parasites and a flow cytometry-based assay for gametocytes, we determined the interactions of PQ with the schizonticides chloroquine, mefloquine, piperaquine, lumefantrine, and naphthoquine. With the sums of fractional inhibitory concentrations and isobolograms, we were able to determine mostly synergistic interactions for the various PQ and schizonticide combinations on the blood stages of P. falciparum laboratory strains. The synergism in inhibiting asexual stages and gametocytes was highly evident with PQ-naphthoquine, whereas synergism was moderate for the PQ-piperaquine, PQ-chloroquine, and PQ-mefloquine combinations. We have detected potentially antagonistic interactions between PQ and lumefantrine under certain drug combination ratios, suggesting that precautions might be needed when PQ is added as the gametocytocide to the artemether-lumefantrine ACT (Coartem). Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  14. Acitretin and aloe-emodin loaded chitin nanogel for the treatment of psoriasis.

    PubMed

    Divya, G; Panonnummal, Rajitha; Gupta, Swati; Jayakumar, R; Sabitha, M

    2016-10-01

    The present study focuses on the development of an effective topical nanogel formulation of two anti-psoriatic drugs; Acitretin (Act) and Aloe-emodin (AE) using natural polymer chitin. Simple regeneration chemistry was used to prepare Chitin Nanogel Systems (CNGs). The developed control chitin (CNGs) nanogels, acitretin loaded chitin nanogels (ActCNGs) and aloe-emodin loaded chitin nanogels (AECNGs) were characterized by DLS, SEM, FTIR, XRD and TG-DTA. The systems were found to be spherical in shape with a size range of 98±10, 138±8 and 238±6nm having zeta potential values of +28±3, +27±3 and +25±6mV for CNGs, ActCNGs and AECNGs respectively. The in vitro haemolysis assay revealed that all the nanogel systems are blood compatible. The systems exhibited higher swelling and release at acidic pH. The ex vivo skin permeation studies using porcine skin confirmed the higher deposition of the systems at epidermal and dermal layers, which was confirmed further by fluorescent imaging. The in vivo anti-psoriatic activity study using Perry's mouse tail model and skin safety studies confirmed the potential benefit of the system for topical delivery of acitretin and aloe-emodin in psoriasis. Copyright © 2016 Elsevier B.V. All rights reserved.

  15. Protection policy for Hawaii's native wildlife during geothermal energy development

    NASA Astrophysics Data System (ADS)

    Hannah, Lee

    1986-09-01

    Hawaii possesses abundant geothermal resources and rare native wildlife. Geothermal energy development has not posed a threat to native wildlife in the past, but development potential has recently reached a level at which concern for native wildlife is warranted. Potential geothermal resource areas in Hawaii intersect important native forest and endangered species habitat. The ability of existing laws to constrain development in these areas is in question. State and federal endangered species and environmental reporting laws have little ability to constrain geothermal development on private land. Hawaii's Land Use Law had been viewed by conservationists as protecting natural areas important to native wildlife, but recent decisions of the state Land Board sharply challenge this view. While this dispute was being resolved in the courts, the state legislature passed the Geothermal Subzone Act of 1983. Wildlife value was assessed in the geothermal subzone designation process mandated by this act, but the subzones designated primarily reflected inappropriate developer influence. All areas in which there was developer interest received subzone designation, and no area in which there was no developer interest was subzoned. This overriding emphasis on developer interest violated the intent of the sub-zone act, and trivialized the importance of other assessment criteria, among them native wildlife values.

  16. Dehydration and osmotic adjustment in apple stem tissue during winter as it relates to the frost resistance of buds.

    PubMed

    Pramsohler, Manuel; Neuner, Gilbert

    2013-08-01

    In deciduous trees, measurement of stem water potential can be difficult during the leafless period in winter. By using thermocouple psychrometry, osmotic water potentials (Ψo; actual Ψo: Ψo(act); Ψo at full saturation: Ψo(sat)) of expressed sap of bark and bud tissue were measured in order to test if the severity of winter desiccation in apple stems could be sufficiently assessed with Ψo. Water potentials were related to frost resistance and freezing behaviour of buds. The determination of Ψo reliably allowed winter desiccation and osmotic adjustments in apple stem tissue to be assessed. In winter in bark tissue, a pronounced decrease in Ψo(act) and Ψo(sat) was found. Decreased Ψo(sat) indicates active osmotic adjustment in the bark as observed earlier in the leaves of evergreen woody plants. In terminal bud meristems, no significant osmotic adjustments occurred and dehydration during winter was much less. Osmotic water potentials, Ψo(act) and Ψo(sat), of bud tissue were always less negative than in the bark. To prevent water movement and dehydration of the bud tissue via this osmotic gradient, it must be compensated for either by a sufficiently high turgor pressure (Ψp) in bark tissue or by the isolation of the bud tissue from the bark during midwinter. During freezing of apple buds, freeze dehydration and extra-organ freezing could be demonstrated by significantly reduced Ψo(act) values of bud meristems that had been excised in the frozen state. Infrared video thermography was used to monitor freezing patterns in apple twigs. During extracellular freezing of intact and longitudinally dissected stems, infrared differential thermal analysis (IDTA) images showed that the bud meristem remains ice free. Even if cooled to temperatures below the frost-killing temperature, no freezing event could be detected in bud meristems during winter. In contrast, after bud break, terminal buds showed a second freezing at the frost-killing temperature that indicates deep supercooling. Our results demonstrate the applicability of thermocouple psychrometry for the assessment of winter desiccation in stem tissues of deciduous trees and corroborate the finding that dormant apple buds survive by extra-organ freezing and do not deep supercool. In addition, they indicate that significant changes of the frost-survival mechanism can occur during the apple bud development in spring.

  17. Soil Management Plan for the Oak Ridge Y-12 National Security Complex Oak Ridge, Tennessee

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    2005-03-02

    This Soil Management Plan applies to all activities conducted under the auspices of the National Nuclear Security Administration (NNSA) Oak Ridge Y-12 National Security Complex (Y-12) that involve soil disturbance and potential management of waste soil. The plan was prepared under the direction of the Y-12 Environmental Compliance Department of the Environment, Safety, and Health Division. Soil disturbances related to maintenance activities, utility and building construction projects, or demolition projects fall within the purview of the plan. This Soil Management Plan represents an integrated, visually oriented, planning and information resource tool for decision making involving excavation or disturbance of soilmore » at Y-12. This Soil Management Plan addresses three primary elements. (1) Regulatory and programmatic requirements for management of soil based on the location of a soil disturbance project and/or the regulatory classification of any contaminants that may be present (Chap. 2). Five general regulatory or programmatic classifications of soil are recognized to be potentially present at Y-12; soil may fall under one or more these classifications: (a) Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) pursuant to the Oak Ridge Reservation (ORR) Federal Facilities Agreement; (b) Resource Conservation and Recovery Act (RCRA); (c) RCRA 3004(u) solid waste managements units pursuant to the RCRA Hazardous and Solid Waste Amendments Act of 1984 permit for the ORR; (d) Toxic Substances and Control Act-regulated soil containing polychlorinated biphenyls; and (e) Radiologically contaminated soil regulated under the Atomic Energy Act review process. (2) Information for project planners on current and future planned remedial actions (RAs), as prescribed by CERCLA decision documents (including the scope of the actions and remedial goals), land use controls implemented to support or maintain RAs, RCRA post-closure regulatory requirements for former waste management units, legacy contamination source areas and distribution of contamination in soils, and environmental infrastructure (e.g., caps, monitoring systems, etc.) that is in place or planned in association with RAs. (3) Regulatory considerations and processes for management and disposition of waste soil upon generation, including regulatory drivers, best management practices (BMPs), waste determination protocols, waste acceptance criteria, and existing waste management procedures and BMPs for Y-12. This Soil Management Plan provides information to project planners to better coordinate their activities with other organizations and programs with a vested interest in soil disturbance activities at Y-12. The information allows project managers and maintenance personnel to evaluate and anticipate potential contaminant levels that may be present at a proposed soil disturbance site prior to commencement of activities and allows a more accurate assessment of potential waste management requirements.« less

  18. Procedures for the Handling of Retaliation Complaints Under Section 1558 of the Affordable Care Act. Final rule.

    PubMed

    2016-10-13

    This document provides the final text of regulations governing employee protection (retaliation or whistleblower) claims under section 1558 of the Affordable Care Act, which added section 18C to the Fair Labor Standards Act to provide protections to employees who may have been subject to retaliation for seeking assistance under certain affordability assistance provisions (for example, health insurance premium tax credits) or for reporting potential violations of the Affordable Care Act's consumer protections (for example, the prohibition on rescissions). An interim final rule (IFR) governing these provisions and request for comments was published in the Federal Register on February 27, 2013. Thirteen comments were received; eleven were responsive to the IFR. This rule responds to those comments and establishes the final procedures and time frames for the handling of retaliation complaints under section 18C, including procedures and time frames for employee complaints to the Occupational Safety and Health Administration (OSHA), investigations by OSHA, appeals of OSHA determinations to an administrative law judge (ALJ) for a hearing de novo, hearings by ALJs, review of ALJ decisions by the Administrative Review Board (ARB) (acting on behalf of the Secretary of Labor), and judicial review of the Secretary of Labor's (Secretary's) final decision. It also sets forth the Secretary's interpretations of the Affordable Care Act whistleblower provision on certain matters.

  19. Quantum lattice representations for vector solitons in external potentials

    NASA Astrophysics Data System (ADS)

    Vahala, George; Vahala, Linda; Yepez, Jeffrey

    2006-03-01

    A quantum lattice algorithm is developed to examine the effect of an external potential well on exactly integrable vector Manakov solitons. It is found that the exact solutions to the coupled nonlinear Schrodinger equations act like quasi-solitons in weak potentials, leading to mode-locking, trapping and untrapping. Stronger potential wells will lead to the emission of radiation modes from the quasi-soliton initial conditions. If the external potential is applied to that particular mode polarization, then the radiation will be trapped within the potential well. The algorithm developed leads to a finite difference scheme that is unconditionally stable. The Manakov system in an external potential is very closely related to the Gross-Pitaevskii equation for the ground state wave functions of a coupled BEC state at T=0 K.

  20. A Novel Method for Gene-Specific Enhancement of Protein Translation by Targeting 5’UTRs of Selected Tumor Suppressors

    PubMed Central

    Master, Adam; Wójcicka, Anna; Giżewska, Kamilla; Popławski, Piotr; Williams, Graham R.; Nauman, Alicja

    2016-01-01

    Background Translational control is a mechanism of protein synthesis regulation emerging as an important target for new therapeutics. Naturally occurring microRNAs and synthetic small inhibitory RNAs (siRNAs) are the most recognized regulatory molecules acting via RNA interference. Surprisingly, recent studies have shown that interfering RNAs may also activate gene transcription via the newly discovered phenomenon of small RNA-induced gene activation (RNAa). Thus far, the small activating RNAs (saRNAs) have only been demonstrated as promoter-specific transcriptional activators. Findings We demonstrate that oligonucleotide-based trans-acting factors can also specifically enhance gene expression at the level of protein translation by acting at sequence-specific targets within the messenger RNA 5’-untranslated region (5’UTR). We designed a set of short synthetic oligonucleotides (dGoligos), specifically targeting alternatively spliced 5’UTRs in transcripts expressed from the THRB and CDKN2A suppressor genes. The in vitro translation efficiency of reporter constructs containing alternative TRβ1 5’UTRs was increased by up to more than 55-fold following exposure to specific dGoligos. Moreover, we found that the most folded 5’UTR has higher translational regulatory potential when compared to the weakly folded TRβ1 variant. This suggests such a strategy may be especially applied to enhance translation from relatively inactive transcripts containing long 5’UTRs of complex structure. Significance This report represents the first method for gene-specific translation enhancement using selective trans-acting factors designed to target specific 5’UTR cis-acting elements. This simple strategy may be developed further to complement other available methods for gene expression regulation including gene silencing. The dGoligo-mediated translation-enhancing approach has the potential to be transferred to increase the translation efficiency of any suitable target gene and may have future application in gene therapy strategies to enhance expression of proteins including tumor suppressors. PMID:27171412

  1. Mineral resource potential map of the Bell Mountain Wilderness Study Area, Iron County, Missouri

    USGS Publications Warehouse

    Pratt, Walden P.; Erickson, Ralph L.; Ellis, Clarence E.

    1982-01-01

    Under the provisions of the Wilderness Act (Public Law 88-577, September 3, 1964) and the Joint Conference Report on Senate Bill 4, 88th Congress, the U.S. Geological Survey and U.S. Bureau of Mines have been conducting mineral surveys of wilderness and primitive areas. Areas officially designated as "wilderness," "wild," or "canoe" when the Act was passed were incorporated into the National Wilderness Preservation System, and some of them are presently being studied. The Act provided that areas under consideration for wilderness designation should be studied for suitability for incorporation into the Wilderness System. The mineral surveys constitute one aspect of the suitability studies. This report discusses the results of a mineral survey of some national forest lands in the Bell Mountain Wilderness Study Area, Iron County, Missouri.

  2. 77 FR 70105 - Delayed Implementation of Certain New Mortgage Disclosures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-23

    ...The Bureau of Consumer Financial Protection (Bureau) is amending Regulation Z (Truth in Lending) to, in effect, delay implementation of certain new mortgage disclosure requirements in title XIV of the Dodd-Frank Wall Street Reform and Consumer Protection Act that would otherwise take effect on January 21, 2013. Instead, to avoid potential consumer confusion and reduce compliance burden for industry, the Bureau plans to implement these disclosures as part of the integrated mortgage disclosure forms proposed earlier this year, which combine certain disclosures that consumers receive in connection with applying for and closing on a mortgage loan under the Truth in Lending Act and the Real Estate Settlement Procedures Act. Accordingly, this rulemaking exempts persons from complying with these mortgage disclosure requirements and provides that such exemptions are intended to last only until the integrated mortgage disclosure forms take effect.

  3. A composite material based on nanoparticles of yttrium (III) oxide for the selective and sensitive electrochemical determination of acetaminophen.

    PubMed

    Baytak, Aysegul Kutluay; Teker, Tugce; Duzmen, Sehriban; Aslanoglu, Mehmet

    2016-09-01

    An electrochemical sensor was prepared by modifying a glassy carbon electrode (GCE) with a composite of yttrium (III) oxide nanoparticles (Y2O3NPs) and carbon nanotubes (CNTs) for the determination of acetaminophen (ACT). Compared with a bare GCE and CNTs/GCE, the Y2O3NPs/CNTs/GCE exhibited a well-defined redox couple for ACT and highly enhanced the current response. The separations in the anodic and cathodic peak potentials (ΔEp) for ACT were 552mV, 24mV and 10mV at ba4re GCE, CNTs/GCE and Y2O3NPs/CNTs/GCE, respectively. The observation of only 10mV of ΔEp for ACT at Y2O3NPs/CNTs/GCE was a clear indication of a great acceleration of the electrode process compared to bare GCE and GCE modified with CNTs. Also, l-ascorbic acid (l-AA) and l-tyrosine (l-TRY) did not interfere with the selective determination of ACT. Square wave voltammetry (SWV) was performed for the quantification of ACT. A linear plot was obtained for current responses versus the concentrations of ACT over the range from 1.0×10(-10) to 1.8×10(-8)M with a detection limit of 3.0×10(-11)M (based on 3Sb/m). The proposed composite material provided high electrocatalytic activity, improved voltammetric behavior, good selectivity and good reproducibility. The accurate quantification of ACT makes the proposed electrode of great interest for the public health. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. Options for Limiting the Potential to Emit (PTE) of a Stationary Source Under Section 112 and Title V of the Clean Air Act (Act)

    EPA Pesticide Factsheets

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  5. Concepts in pain management.

    PubMed

    Gulur, Padma; Soldinger, Simon Maurice; Acquadro, Martin A

    2007-04-01

    Pain has become an increasingly recognized symptom that plays a major role in the treatment of many podiatric patients. Management of this now accepted fifth vital sign can be accomplished through many avenues. Nonsteroidal anti-inflammatory medications and short- and long-acting opioids are typically used by many podiatric physicians; however, the benefits and potential hazards of other pharmaceutic approaches using antidepressants, anticonvulsants, topical medications, and other centrally acting medications must also be recognized. In addition, the role of the psychiatrist or therapist should not be neglected because many types of cognitive therapies are available to aid in treating these patients.

  6. 40 CFR 6.100 - Policy and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ENVIRONMENTAL POLICY ACT AND ASSESSING THE ENVIRONMENTAL EFFECTS ABROAD OF EPA ACTIONS General Provisions for... processes appropriate and careful consideration of all environmental effects of proposed actions, analyze potential environmental effects of proposed actions and their alternatives for public understanding and...

  7. Emission Reduction Potential of the Congestion Mitigation and Air Quality Program

    DOT National Transportation Integrated Search

    1997-05-19

    The Congestion Mitigation and Air Quality Improvement Program (CMAQ) provides : funds to states for projects designed to help attain and maintain the national : ambient air quality standards (NAAQS) set under the Clean Air Act (CAA). CMAQ : was creat...

  8. 10 CFR 820.41 - Compliance order.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... The Secretary may issue to any person involved in a DOE nuclear activity a Compliance Order that: (a) Identifies a situation that violates, potentially violates, or otherwise is inconsistent with the Act, a...) States the reasons for the remedy or other action. ...

  9. HANDBOOK: RECYCLING AND REUSE OF MATERIAL FOUND ON SUPERFUND SITES

    EPA Science Inventory

    This document provides assistance in identifying potential recycling technologies for a wide variety of contaminants and matrices. Personnel at Superfund and Resource Conservation and Recovery Act (RCRA) Corrective Action sites face the challenge of selecting remedial options for...

  10. 21 CFR 316.3 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... differences in amino acid sequence; other potentially important differences, such as different glycosylation... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS FOR HUMAN USE... subject to investigation and approval under the act or the biologics provisions of the Public Health...

  11. 21 CFR 316.3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... differences in amino acid sequence; other potentially important differences, such as different glycosylation... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS FOR HUMAN USE... subject to investigation and approval under the act or the biologics provisions of the Public Health...

  12. INCREASED SUSCEPTIBILITY OF ADULTS FOLLOWING DEVELOPMENT EXPOSURE TO NEUROTOXICANTS: ANOTHER SUSCEPTIBLE POPULATION?

    EPA Science Inventory

    There is considerable public and regulatory interest in the adverse outcomes of developmental exposure to toxicants. The 1996 Food Quality Protection Act spurred research on understanding potential neurotoxic, immunotoxic, and endocrine outcomes in susceptible populations, parti...

  13. POTENTIAL DEVELOPMENTAL TOXICITY OF ANATOXIN-A, A CYANOBACTERIAL TOXIN

    EPA Science Inventory

    Anatoxin-a acts as a neuro-muscular blocking agent. Acute toxicity is characterized by rapid onset of paralysis, tremors, convulsions, and death. Human exposures may occur from recreational water activities and dietary supplements, but are primarily through drinking water. The...

  14. Carbon Dioxide as a Fire Suppressant: Examining the Risks

    EPA Pesticide Factsheets

    Under the Clean Air Act Amendments of 1990, the U.S. Environmental Protection Agency (EPA) has the statutory authority to set phase-out dates for ozone-depleting substances (ODS) and to evaluate potential risks posed by proposed ODS substitutes.

  15. Effects of deceleration and rate of deceleration on live seated human subjects

    DOT National Transportation Integrated Search

    1977-10-01

    This report describes the testing of live, seated human subjects to determine : the maximum deceleration and associated rate of change of deceleration (jerk) at : which the majority of potential users of automated guideway transportation (ACT) : syst...

  16. Information about Federal Assistance Listings and the Catalog of Federal Domestic Assistance

    EPA Pesticide Factsheets

    The primary purpose of the Catalog is to assist potential applicants in identifying programs which meet their specific objectives & to provide general information on Federal assistance programs. In 1977 Congress passed the Federal Program Information Act.

  17. DETERMINING INHALATION RISK -- TOOLS FOR ASSESSING HAZARD.

    EPA Science Inventory

    The Clean Air Act focuses on reduction of the potential for specific air pollutants to cause adverse health effects. Implementation of standards to control release of the 188 hazardous air pollutants (HAPs) requires the Environmental Protection Agency (EPA) to evaluate the healt...

  18. 78 FR 54629 - Fisheries of the Exclusive Economic Zone Off Alaska; American Fisheries Act, Amendment 80 Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-05

    ... Alaska Community Development Quota (CDQ) Program, and the hook-and-line catcher/processor (freezer... plans to present a draft analysis of the potential effects of cost recovery fee programs to the Council...

  19. The Performance and Registration Information Systems Management (PRISM) pilot demonstration project

    DOT National Transportation Integrated Search

    1999-12-01

    The Intermodal Surface Transportation Efficiency Act of 1991 mandated a study to explore the potential of the commercial motor vehicle (CMV) registration process as a safety enforcement tool for reducing CMV accidents. The project sought to establish...

  20. Growing an Integrated Unit--Organically!

    ERIC Educational Resources Information Center

    Clipsham, Dianne; Charbonneau, Letitia

    1994-01-01

    Describes an interdisciplinary grade eight unit on food that incorporates the goals and methods of global education. In this unit, three teachers worked to develop the potential of students to direct their own learning and to develop and act on new perspectives. (LZ)

  1. 78 FR 21150 - Notice of Lodging of Proposed Amendment to Consent Decree Under the Clean Water Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-09

    ... forth a phased sequence and schedule for the decision-making process of HRSD and the Localities as they... \\1\\ are evaluating the potential benefits and feasibility of regionalization and consolidation of the...

  2. Air Quality Programs and Provisions of the Intermodal Surface Transportation Efficiency Act of 1991

    DOT National Transportation Integrated Search

    2012-11-01

    The US DOT sponsored Dynamic Mobility Applications (DMA) program seeks to identify, develop, and deploy applications that leverage the full potential of connected vehicles, travelers and infrastructure to enhance current operational practices and tra...

  3. Recovery Potential Screening for Prioritizing Restoration in Maryland Watersheds

    EPA Science Inventory

    States’ responsibilities under the Clean Water Act include identifying impaired waters (those not achieving Water Quality Standards) and ultimately restoring them. The high numbers of impaired waters in most states calls for yearly priority-setting decisions on restoration fundin...

  4. Compatibility of the Chameleon-Field Model with Fifth-Force Experiments, Cosmology, and PVLAS and CAST Results

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Brax, Philippe; Bruck, Carsten van de; Davis, Anne-Christine

    2007-09-21

    We analyze the PVLAS results using a chameleon field whose properties depend on the environment. We find that, assuming a runaway bare potential V({phi}) and a universal coupling to matter, the chameleon potential is such that the scalar field can act as dark energy. Moreover, the chameleon-field model is compatible with the CERN Axion Solar Telescope results, fifth-force experiments, and cosmology.

  5. Seizures as a Potential Complication of Treatment With Simeprevir and Sofosbuvir.

    PubMed

    Syal, Gaurav; Heldenbrand, Seth D; Duarte-Rojo, Andres

    2016-01-01

    Newer direct-acting antiviral agents have revolutionized the medical management of chronic hepatitis C. In addition to being extremely efficacious, they report very mild adverse drug reactions from experience in clinical trials. However, because they are relatively new on the horizon, postmarketing surveillance studies refining the safety profile are not yet available. We present a case of seizures as a potential side effect of antiviral therapy with sofosbuvir and simeprevir.

  6. Environmental Impact Statement. Deactivation of the Minuteman II Missile Wing at Whiteman Air Force Base, Missouri

    DTIC Science & Technology

    1992-08-01

    Hazardous Air Pollutants NHPA National Historic Preservation Act NIOSH National Institute for Occupational Safety and Health 1 NOEL no observed effect ...Pantex 3 document concluded that direct measurable effects to the health and safety of the general public or adverse impacts to the environment are likely...safety; and transportation accident potential. Solid wastes and underground storage tanks are also discussed in thic ection. Potential effects to health

  7. The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act.

    PubMed

    Johnson, Matthew W; Griffiths, Roland R; Hendricks, Peter S; Henningfield, Jack E

    2018-06-05

    This review assesses the abuse potential of medically-administered psilocybin, following the structure of the 8 factors of the US Controlled Substances Act (CSA). Research suggests the potential safety and efficacy of psilocybin in treating cancer-related psychiatric distress and substance use disorders, setting the occasion for this review. A more extensive assessment of abuse potential according to an 8-factor analysis would eventually be required to guide appropriate schedule placement. Psilocybin, like other 5-HT2A agonist classic psychedelics, has limited reinforcing effects, supporting marginal, transient non-human self-administration. Nonetheless, mushrooms with variable psilocybin content are used illicitly, with a few lifetime use occasions being normative among users. Potential harms include dangerous behavior in unprepared, unsupervised users, and exacerbation of mental illness in those with or predisposed to psychotic disorders. However, scope of use and associated harms are low compared to prototypical abused drugs, and the medical model addresses these concerns with dose control, patient screening, preparation and follow-up, and session supervision in a medical facility. (1) psilocybin has an abuse potential appropriate for CSA scheduling if approved as medicine; (2) psilocybin can provide therapeutic benefits that may support the development of an approvable New Drug Application (NDA) but further studies are required which this review describes; (3) adverse effects of medical psilocybin are manageable when administered according to risk management approaches; and (4) although further study is required, this review suggests that placement in Schedule IV may be appropriate if a psilocybin-containing medicine is approved. Copyright © 2018. Published by Elsevier Ltd.

  8. Care homes and the Mental Capacity Act 2005: Changes in understanding and practice over time.

    PubMed

    Manthorpe, Jill; Samsi, Kritika

    2016-07-01

    The Mental Capacity Act 2005 provides the legal framework in England and Wales for the making of decisions in respect of people who have never had or have lost decision-making capacity. As part of a 5-year research program investigating the implementation and adoption of the Mental Capacity Act in dementia practice, we interviewed staff working in different care homes at two time points (32 staff at Time 1 in 2008 and 27 staff at Time 2 in 2012) in South East England. At baseline Time 1, daily practice seemed to resonate with Mental Capacity Act principles of respecting decisions and trying to act in a person's best interests. This paper reports Time 2 findings. We found that few care home staff interviewed specifically reported finding the Mental Capacity Act helpful in crystallizing the legal basis of their work. Most continued to offer illustrations of day-to-day practice in which they paid attention to individual choices, took account of the wishes of residents' families, and tried to act in residents' best interests but referred major decisions to their seniors. This study highlights the potential of referring to specific day-to-day practice in care homes when offering training or scrutinizing practice in dementia care more generally so that the work is set in its legal as well as moral framework. Care home staff in this study reported that advanced planning and pre-specifying preferences were more common among new care home residents, especially those with dementia, indicating that greater understanding of these is required by staff. © The Author(s) 2014.

  9. Adoptive Transfer of Tumor-Specific Th2 Cells Eradicates Tumors by Triggering an In Situ Inflammatory Immune Response.

    PubMed

    Lorvik, Kristina Berg; Hammarström, Clara; Fauskanger, Marte; Haabeth, Ole Audun Werner; Zangani, Michael; Haraldsen, Guttorm; Bogen, Bjarne; Corthay, Alexandre

    2016-12-01

    Adoptive cell therapy (ACT) trials to date have focused on transfer of autologous tumor-specific cytotoxic CD8 + T cells; however, the potential of CD4 + T helper (Th) cells for ACT is gaining interest. While encouraging results have been reported with IFNγ-producing Th1 cells, tumor-specific Th2 cells have been largely neglected for ACT due to their reported tumor-promoting properties. In this study, we tested the efficacy of idiotype-specific Th2 cells for the treatment of mice with MHC class II-negative myeloma. Th2 ACT efficiently eradicated subcutaneous myeloma in an antigen-specific fashion. Transferred Th2 cells persisted in vivo and conferred long-lasting immunity. Cancer eradication mediated by tumor-specific Th2 cells did not require B cells, natural killer T cells, CD8 + T cells, or IFNγ. Th2 ACT was also curative against B-cell lymphoma. Upon transfer, Th2 cells induced a type II inflammation at the tumor site with massive infiltration of M2-type macrophages producing arginase. In vivo blockade of arginase strongly inhibited Th2 ACT, consistent with a key role of arginase and M2 macrophages in myeloma elimination by Th2 cells. These results illustrate that cancer eradication may be achieved by induction of a tumor-specific Th2 inflammatory immune response at the tumor site. Thus, ACT with tumor-specific Th2 cells may represent a highly efficient immunotherapy protocol against cancer. Cancer Res; 76(23); 6864-76. ©2016 AACR. ©2016 American Association for Cancer Research.

  10. An attribution theory perspective on emotional labour in nurse-patient encounters: a nested cross-sectional study in paediatric settings.

    PubMed

    Golfenshtein, Nadya; Drach-Zahavy, Anat

    2015-05-01

    To understand the role of patients' attributions under the attribution theory framework (locus, controllability, stability) in nurses' performance of surface or deep acting, as they unfold in interactions with different patients. Regulation of emotions at work, or emotional labour, has been conceptualized in terms of two main strategies: surface acting and deep acting. Most prior research tested for between-subject variation in the search for the factors evoking these strategies in nurses, assuming them to be trait-like characteristics. Only scant research has examined how nurses modify their emotional labour strategies in different patient-nurse encounters. A nested cross-sectional design (patients within nurses). Data were collected during 2011-2012 through validated questionnaires from the nursing staff (N = 41) of two paediatric hospital wards and their randomly selected patients (N = 239). Questionnaires were administered to nurses multiple times after encounters with different patients. Analyses were conducted using mixed effects models. In accordance with attribution theory, different combinations of locus, controllability and stability attributions were related to the choice of surface or deep acting. Nurses' perceptions of patients' controllability were associated positively with surface acting and negatively with deep acting. Interaction terms of stability and locus and of controllability and stability, were distinctively associated with deep and surface acting. Findings innovatively introduce the attribution process as an explanatory perspective to nurses' emotional labour and highlight its situational nature, providing a potential tool for emotional labour strategy prediction. Raising nurses' awareness of how they perceive patients may increase control of the strategies employed. © 2015 John Wiley & Sons Ltd.

  11. Patient Protection and Affordable Care Act; standards related to reinsurance, risk corridors, and risk adjustment. Final rule.

    PubMed

    2012-03-23

    This final rule implements standards for States related to reinsurance and risk adjustment, and for health insurance issuers related to reinsurance, risk corridors, and risk adjustment consistent with title I of the Patient Protection and Affordable Care Act as amended by the Health Care and Education Reconciliation Act of 2010, referred to collectively as the Affordable Care Act. These programs will mitigate the impact of potential adverse selection and stabilize premiums in the individual and small group markets as insurance reforms and the Affordable Insurance Exchanges ("Exchanges") are implemented, starting in 2014. The transitional State-based reinsurance program serves to reduce uncertainty by sharing risk in the individual market through making payments for high claims costs for enrollees. The temporary Federally administered risk corridors program serves to protect against uncertainty in rate setting by qualified health plans sharing risk in losses and gains with the Federal government. The permanent State-based risk adjustment program provides payments to health insurance issuers that disproportionately attract high-risk populations (such as individuals with chronic conditions).

  12. Mineral resource potential map of the John Muir Wilderness, Fresno, Inyo, Madera, and Mono counties, California

    USGS Publications Warehouse

    Du Bray, E.A.; Dellinger, D.A.; Diggles, M.F.; Oliver, H.W.; Johnson, F.L.; Thurber, H.K.; Morris, R.W.; Perers, T.J.; Lindsey, D.S.

    1982-01-01

    Under the provisions of the Wilderness Act (Public Law 88-577, September 3, 1964) and the Joint Conference Report on Senate Bill 4, 88th Congress, the U.S. Geological Survey and the U.S. Bureau of Mines have been conducting mineral surveys of wilderness and primitive areas. Areas officially designated as "wilderness," "wild," or "canoe" when the act was passed were incorporated into the National Wilderness Preservation System, and some of them are presently being studied. The act provided that areas under consideration for wilderness designation should be studied for suitability for incorporation into the Wilderness System. The mineral surveys constitute one aspect of the suitability studies. The act directs that the results of such surveys are to be made available to the public and be submitted to the President and the Congress. This report discusses the results of a mineral survey of the John Muir Wilderness, Inyo and Sierra National Forests, Fresno, lnyo, Madera, and Mono Counties, California. The area was established as a wilderness by Public Law 88-577, September 3, 1964.

  13. Mineral resource potential map of the Buffalo Peaks Wilderness Study Area, Lake, Park, and Chaffee Counties, Colorado

    USGS Publications Warehouse

    Hedlund, D.C.; Nowlan, G.A.; Wood, R.H.

    1983-01-01

    Under the provisions of the Wilderness Act (Public Law 88-577, September 3, 1964) and the Joint Conference Report on Senate Bill 4, 88th Congress, the U.S. Geological Survey and the U.S. Bureau of Mines have been conducting mineral surveys of wilderness and primitive areas. Areas officially designated as "wilderness," "wild," or "canoe" when the act was passed were incorporated into the National Wilderness Preservation System, and some of them are presently being studied. The act provided that areas under consideration for wilderness designation should be studied for suitability for incorporation into the Wilderness System. The mineral surveys constitute one aspect of the suitability studies. The act directs that the results of such surveys are to be made available to the public and be submitted to the President and the Congress. This report discusses the results of a mineral survey of the Buffalo Peaks Wilderness Study Area, Pike and San Isabel National Forests, Lake, Park, and Chaffee Counties, Colo. The area was established as a wilderness study area by Public Law 96-560, December 22, 1980.

  14. Procedures for the handling of retaliation complaints under section 1558 of the Affordable Care Act. Interim final rule; request for comments.

    PubMed

    2013-02-27

    This document provides the interim final regulations governing the employee protection (whistleblower) provision of section 1558 of the Affordable Care Act, which added section 18C of the Fair Labor Standards Act, to provide protections to employees of health insurance issuers or other employers who may have been subject to retaliation for reporting potential violations of the law's consumer protections (e.g., the prohibition on denials of insurance due to pre-existing conditions) or affordability assistance provisions (e.g., access to health insurance premium tax credits). This interim rule establishes procedures and time frames for the handling of retaliation complaints under section 18C, including procedures and time frames for employee complaints to the Occupational Safety and Health Administration (OSHA), investigations by OSHA, appeals of OSHA determinations to an administrative law judge (ALJ) for a hearing de novo, hearings by ALJs, review of ALJ decisions by the Administrative Review Board (ARB) (acting on behalf of the Secretary of Labor), and judicial review of the Secretary's final decision.

  15. Best Interests in the Mental Capacity Act: Time to say Goodbye?

    PubMed Central

    2016-01-01

    Article 12 of the United Nations Convention on the Rights of Persons with Disabilities, as interpreted by the Committee on the Rights of Persons with Disabilities in General Comment No. 1, offers a vision for law’s response to capacity impairments which differs in crucial ways from that contained in the Mental Capacity Act 2005. The Committee rejects the functional test for capacity and requires that a ‘will and preferences’ paradigm must replace the ‘best interests’ paradigm and that all substitute decision-making regimes must be abolished. This article draws on the position adopted in General Comment No. 1 in evaluating the best interests standard in the Mental Capacity Act. It sets out the normative case for a stronger legislative endorsement of will and preferences and the inclusion of greater support mechanisms but rejects the contention that all substitute decision-making can, or should, be abolished. It also argues that the best interests standard in the Mental Capacity Act retains some revolutionary potential and that, pending legislative reform, this can be further developed through the courts. PMID:28007806

  16. Design of nanoengineered hybrid PVA/PNIPAm/CaCl2/SiO2-Polystyrene (PSt) colloidal crystal hydrogel coatings that sweat/rehydrate H2O from the atmosphere to give sustainable cooling and self-indicate their state

    NASA Astrophysics Data System (ADS)

    Eloi, Jean-Charles; Worsley, Myles P.; Sermon, Paul A.; Healy, William; Dimech, Christine

    2016-09-01

    The potential for nanoengineering hybrid PVA hydrogel and hydrogel microsphere optical coatings is demonstrated with fine-tuning by the addition of (i) PNIPAm domains, (ii) water-hunting humectant CaCl2, and (ii) polystyrene or SiO2 colloidal crystals. The design and application onto substrates of the hydrogel scaffold is described. The addition of a temperature-triggered component as well as humectant and NIR reflectors are reported. The hybrid hydrogels appeared effective in sustainable adsorption cooling technology (ACT) over sustained periods. It is shown that the thermoresponsive (PNIPAm) domains act as an extra reserve, sweating water above 305K, prolonging the controlled release of water. It is also reported that the addition of humectant is crucial for the natural re-hydration of the hydrogels. For the moment PNIPAm microspheres have only short- lived ACT properties. Finally, coating with microspheres (MSs) in hydrogels produces a visible-NIR reflector effect that may allow optical feedback on ACT.

  17. Areas of Potential Impact of the Patient Protection and Affordable Care Act on EMS: A Synthesis of the Literature.

    PubMed

    Ostermayer, Daniel G; Brown, Charles A; Fernandez, William G; Couvillon, Emily

    2017-04-01

    This comprehensive review synthesizes the existing literature on the Patient Protection and Affordable Care Act (ACA) as it relates to emergency medical services (EMS) in order to provide guidance for navigating current and future healthcare changes. We conducted a comprehensive review to identify all existing literature related to the ACA and EMS and all sections within the federal law pertaining to EMS. Many changes enacted by the ACA directly affect emergency care with potential indirect effects on EMS systems. New Medicaid enrollees and changes to existing coverage plans may alter EMS transport volumes. Reimbursement changes such as adjustments to the ambulance inflation factor (AIF) alter the yearly increases in EMS reimbursement by incorporating the multifactor productivity value into yearly reimbursement adjustments. New initiatives, funded by the Center for Medicare & Medicaid Innovation are exploring novel and cost-effective prehospital care delivery opportunities while EMS agencies individually explore partnerships with healthcare systems. EMS systems should be aware of the direct and indirect impact of ACA on prehospital care due to the potential for changes in financial reimbursement, acuity and volume changes, and ongoing new care delivery initiatives.

  18. Areas of Potential Impact of the Patient Protection and Affordable Care Act on EMS: A Synthesis of the Literature

    PubMed Central

    Ostermayer, Daniel G.; Brown, Charles A.; Fernandez, William G.; Couvillon, Emily

    2017-01-01

    Introduction This comprehensive review synthesizes the existing literature on the Patient Protection and Affordable Care Act (ACA) as it relates to emergency medical services (EMS) in order to provide guidance for navigating current and future healthcare changes. Methods We conducted a comprehensive review to identify all existing literature related to the ACA and EMS and all sections within the federal law pertaining to EMS. Results Many changes enacted by the ACA directly affect emergency care with potential indirect effects on EMS systems. New Medicaid enrollees and changes to existing coverage plans may alter EMS transport volumes. Reimbursement changes such as adjustments to the ambulance inflation factor (AIF) alter the yearly increases in EMS reimbursement by incorporating the multifactor productivity value into yearly reimbursement adjustments. New initiatives, funded by the Center for Medicare & Medicaid Innovation are exploring novel and cost-effective prehospital care delivery opportunities while EMS agencies individually explore partnerships with healthcare systems. Conclusion EMS systems should be aware of the direct and indirect impact of ACA on prehospital care due to the potential for changes in financial reimbursement, acuity and volume changes, and ongoing new care delivery initiatives. PMID:28435495

  19. Metacognition and abstract reasoning.

    PubMed

    Markovits, Henry; Thompson, Valerie A; Brisson, Janie

    2015-05-01

    The nature of people's meta-representations of deductive reasoning is critical to understanding how people control their own reasoning processes. We conducted two studies to examine whether people have a metacognitive representation of abstract validity and whether familiarity alone acts as a separate metacognitive cue. In Study 1, participants were asked to make a series of (1) abstract conditional inferences, (2) concrete conditional inferences with premises having many potential alternative antecedents and thus specifically conducive to the production of responses consistent with conditional logic, or (3) concrete problems with premises having relatively few potential alternative antecedents. Participants gave confidence ratings after each inference. Results show that confidence ratings were positively correlated with logical performance on abstract problems and concrete problems with many potential alternatives, but not with concrete problems with content less conducive to normative responses. Confidence ratings were higher with few alternatives than for abstract content. Study 2 used a generation of contrary-to-fact alternatives task to improve levels of abstract logical performance. The resulting increase in logical performance was mirrored by increases in mean confidence ratings. Results provide evidence for a metacognitive representation based on logical validity, and show that familiarity acts as a separate metacognitive cue.

  20. How does the urothelium affect bladder function in health and disease?

    PubMed Central

    Birder, L.A.; Ruggieri, M.; Takeda, M.; van Koeveringe, G.; Veltkamp, S.A.; Korstanje, C.; Parsons, B.A.; Fry, C.H.

    2011-01-01

    The urothelium is a multifunctional tissue that not only acts as a barrier between the vesical contents of the lower urinary tract and the underlying tissues but also acts as a sensory organ by transducing physical and chemical stresses to the attendant afferent nervous system and underlying smooth muscle. This review will consider the nature of the stresses that the urothelium can transduce; the transmitters that mediate the transduction process; and how lower urinary pathologies, including overactive bladder syndrome, painful bladder syndrome and bacterial infections, are associated with alterations to this sensory system. In particular, the role of muscarinic receptors and the TRPV channels system will be discussed in this context. The urothelium also influences the contractile state of detrusor smooth muscle, both through modifying its contractility and the extent of spontaneous activity; potential pathways are discussed. The potential role that the urothelium may play in bladder underactivity is introduced, as well as potential biomarkers for the condition that may cross the urothelium to the urine. Finally consideration is given to vesical administration of therapeutic agents that influence urinary tract function and how the properties of the urothelium may determine the effectiveness of this mode of delivery. PMID:22275289

  1. A Meta-Analysis of Multiple Matched Copy Number and Transcriptomics Data Sets for Inferring Gene Regulatory Relationships

    PubMed Central

    Newton, Richard; Wernisch, Lorenz

    2014-01-01

    Inferring gene regulatory relationships from observational data is challenging. Manipulation and intervention is often required to unravel causal relationships unambiguously. However, gene copy number changes, as they frequently occur in cancer cells, might be considered natural manipulation experiments on gene expression. An increasing number of data sets on matched array comparative genomic hybridisation and transcriptomics experiments from a variety of cancer pathologies are becoming publicly available. Here we explore the potential of a meta-analysis of thirty such data sets. The aim of our analysis was to assess the potential of in silico inference of trans-acting gene regulatory relationships from this type of data. We found sufficient correlation signal in the data to infer gene regulatory relationships, with interesting similarities between data sets. A number of genes had highly correlated copy number and expression changes in many of the data sets and we present predicted potential trans-acted regulatory relationships for each of these genes. The study also investigates to what extent heterogeneity between cell types and between pathologies determines the number of statistically significant predictions available from a meta-analysis of experiments. PMID:25148247

  2. Biofuel cell based on direct bioelectrocatalysis.

    PubMed

    Ramanavicius, Arunas; Kausaite, Asta; Ramanaviciene, Almira

    2005-04-15

    A biofuel cell, consisting of two 3mm diameter carbon rod electrodes and operating at ambient temperature in aqueous solution, pH 6, is described. Biofuel cell based on enzymes able to exchange directly electrons with carbon electrodes was constructed and characterized. Anode of the biofuel cell was based on immobilized Quino-hemoprotein alcohol dehydrogenase from Gluconobacter sp. 33 (QH-ADH), cathode on co-immobilized glucose oxidase from Aspergilus niger (GO(x)) and microperoxidase 8 from the horse heart (MP-8) acting in the consecutive mode. Two enzymes GO(x) and MP-8 applied in the design of biofuel cell cathode were acting in consecutive mode and by hydrogen peroxide oxidized MP-8 was directly accepting electrons from carbon rod electrode. If ethanol was applied as an energy source the maximal open circuit potential of the biofuel cell was -125 mV. If glucose was applied as energy source the open circuit potential of the cell was +145 mV. The maximal open circuit potential (270 mV) was achieved in the presence of extent concentration (over 2 mM) of both substrates (ethanol and glucose). Operational half-life period (tau(1/2)) of the biofuel cell was found to be 2.5 days.

  3. Dress codes and appearance policies: challenges under federal legislation, part 3: Title VII, the Americans with Disabilities Act, and the National Labor Relations Act.

    PubMed

    Mitchell, Michael S; Koen, Clifford M; Darden, Stephen M

    2014-01-01

    As more and more individuals express themselves with tattoos and body piercings and push the envelope on what is deemed appropriate in the workplace, employers have an increased need for creation and enforcement of reasonable dress codes and appearance policies. As with any employment policy or practice, an appearance policy must be implemented and enforced without regard to an individual's race, color, sex, national origin, religion, disability, age, or any other protected status. A policy governing dress and appearance based on the business needs of an employer that is applied fairly and consistently and does not have a disproportionate effect on any protected class will generally be upheld if challenged in court. By examining some of the more common legal challenges to dress codes and how courts have resolved the disputes, health care managers can avoid many potential problems. This article, the third part of a 3-part examination of dress codes and appearance policies, focuses on the issues of race and national origin under the Civil Rights Act, disability under the Americans With Disabilities Act, and employees' rights to engage in concerted activities under the National Labor Relations Act. Pertinent court cases that provide guidance for employers are addressed.

  4. Long-term use of short- and long-acting nitrates in stable angina pectoris.

    PubMed

    Kosmicki, Marek Antoni

    2009-05-01

    Long-acting nitrates are effective antianginal drugs during initial treatment. However, their therapeutic value is compromised by the rapid development of tolerance during sustained therapy, which means that their clinical efficacy is decreased during long-term use. Sublingual nitroglycerin (NTG), a short-acting nitrate, is suitable for the immediate relief of angina. In patients with stable angina treated with oral long-acting nitrates, NTG maintains its full anti-ischemic effect both after initial oral ingestion and after intermittent long-term oral administration. However, NTG attenuates this effect during continuous treatment, when tolerance to oral nitrates occurs, and this is called cross-tolerance. In stable angina long-acting nitrates are considered third-line therapy because a nitrate-free interval is required to avoid the development of tolerance. Nitrates vary in their potential to induce the development of tolerance. During long-lasting nitrate therapy, except pentaerythritol tetranitrate (PETN), one can observe the development of reactive oxygen species (ROS) inside the muscular cell of a vessel wall, and these bind with nitric oxide (NO). This leads to decreased NO activity, thus, nitrate tolerance. PETN has no tendency to form ROS, and therefore during long-term PETN therapy, there is probably no tolerance or cross-tolerance, as during treatment with other nitrates.

  5. Personality and affective forecasting: trait introverts underpredict the hedonic benefits of acting extraverted.

    PubMed

    Zelenski, John M; Whelan, Deanna C; Nealis, Logan J; Besner, Christina M; Santoro, Maya S; Wynn, Jessica E

    2013-06-01

    People report enjoying momentary extraverted behavior, and this does not seem to depend on trait levels of introversion-extraversion. Assuming that introverts desire enjoyment, this finding raises the question, why do introverts not act extraverted more often? This research explored a novel explanation, that trait introverts make an affective forecasting error, underpredicting the hedonic benefits of extraverted behavior. Study 1 (n = 97) found that trait introverts forecast less activated positive and pleasant affect and more negative and self-conscious affect (compared to extraverts) when asked to imagine acting extraverted, but not introverted, across a variety of hypothetical situations. Studies 2-5 (combined n = 495) found similar results using a between-subjects approach and laboratory situations. We replicated findings that people enjoy acting extraverted and that this does not depend on disposition. Accordingly, the personality differences in affective forecasts represent errors. In these studies, introverts tended to be less accurate, particularly by overestimating the negative affect and self-consciousness associated with their extraverted behavior. This may explain why introverts do not act extraverted more often (i.e., they overestimate hedonic costs that do not actually materialize) and have implications for understanding, and potentially trying to change, introverts' characteristically lower levels of happiness. PsycINFO Database Record (c) 2013 APA, all rights reserved.

  6. 78 FR 4968 - Privacy Act of 1974, Computer Matching Program-U.S. Small Business Administration and U.S...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-23

    ... hurricanes Katrina and Rita, and referred 67,023 of those registrations to SBA as potential duplicates. Excluding the Katrina and Rita disasters, DHS/FEMA received 7,070,068 registrations from 1998-2009, and...

  7. 75 FR 35847 - Privacy Act of 1974, Computer Matching Program-U.S. Small Business Administration and U.S...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-23

    ... response to hurricanes Katrina and Rita, and referred 67,023 of those registrations to SBA as potential duplicates. Excluding the Katrina and Rita disasters, DHS/FEMA received 7,070,068 registrations from 1998...

  8. 29 CFR 1626.7 - Timeliness of charge.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... discrimination law and authority administering that law, within 300 days of the alleged discriminatory action, or... Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.7 Timeliness of charge. (a) Potential charging parties will be advised...

  9. 29 CFR 1626.7 - Timeliness of charge.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... discrimination law and authority administering that law, within 300 days of the alleged discriminatory action, or... Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.7 Timeliness of charge. (a) Potential charging parties will be advised...

  10. 29 CFR 1626.7 - Timeliness of charge.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... discrimination law and authority administering that law, within 300 days of the alleged discriminatory action, or... Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.7 Timeliness of charge. (a) Potential charging parties will be advised...

  11. 29 CFR 1626.7 - Timeliness of charge.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... discrimination law and authority administering that law, within 300 days of the alleged discriminatory action, or... Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.7 Timeliness of charge. (a) Potential charging parties will be advised...

  12. 29 CFR 1626.7 - Timeliness of charge.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... discrimination law and authority administering that law, within 300 days of the alleged discriminatory action, or... Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.7 Timeliness of charge. (a) Potential charging parties will be advised...

  13. Social Evolution: Uneasy Lies the Head.

    PubMed

    Bourke, Andrew F G

    2015-11-16

    Inclusive fitness theory explains why workers in insect societies sometimes kill their queen. As the theory predicts, workers in a wasp species are more likely to act matricidally when more highly related to potential worker offspring. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. 75 FR 27537 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-17

    ... and discuss a number of issues relating to U.S. Government-funded non-military international broadcasting. They will address internal procedural, budgetary, and personnel issues, as well as sensitive foreign policy issues relating to potential options in the U.S. international broadcasting field. This...

  15. 7 CFR 3565.255 - Environmental requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Environmental requirements. 3565.255 Section 3565.255... AGRICULTURE GUARANTEED RURAL RENTAL HOUSING PROGRAM Property Requirements § 3565.255 Environmental requirements. Under the National Environmental Policy Act, the Agency is required to assess the potential...

  16. Report: EPA’s Endocrine Disruptor Screening Program Should Establish Management Controls to Ensure More Timely Results

    EPA Pesticide Factsheets

    Report #11-P-0215, May 3, 2011. Fourteen years after passage of the FQPA and Safe Drinking Water Act amendments, EPA’s EDSP has not determined whether any chemical is a potential endocrine disruptor.

  17. The effects of glyphosate and aminopyralid on an artifical plant communities

    EPA Science Inventory

    The US EPA has responsibility for registration of pesticides under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA). The potential adverse effects of pesticides to nontarget terrestrial plant communities are a concern that must be addressed in the pesticide regist...

  18. Implementation of Systems Engineering Practices into a Capstone Course

    NASA Technical Reports Server (NTRS)

    Murphy, Gloria; Schmidt, Peter

    2011-01-01

    Discusses the NASA Exploration Systems Mission Directorate senior design projects which are to provide students with senior design project ideas, with potential contribution to NASA ESMD objectives. and provides NASA technical representative to act as external customer / technology mentor / requirements source.

  19. Persuasion, Surveillance, and Voting Behavior

    ERIC Educational Resources Information Center

    Gross, Alan E.; And Others

    1974-01-01

    The present study was designed to test the efficacy of two basic strategies which might be employed to increase the probability that a potential voter will act in accordance with his presumed belief that it is right, good, or desirable to exercise his franchise. (Author)

  20. 16 CFR 1633.8 - Findings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT REGULATIONS STANDARD FOR THE FLAMMABILITY... regulation has been adopted and implemented. (c) Relationship of benefits to costs. The Commission estimates the potential total lifetime benefits of a mattress that complies with this standard to range from $45...

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