45 CFR 147.140 - Preservation of right to maintain existing coverage.

Code of Federal Regulations, 2012 CFR

2012-10-01

... RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE REFORM REQUIREMENTS FOR THE GROUP AND INDIVIDUAL HEALTH... grandfathered health plan within the meaning of section 1251 of the Patient Protection and Affordable Care Act... Affordable Care Act, do not apply to grandfathered health plans. In addition, the provisions of PHS Act...

21 CFR 312.120 - Foreign clinical studies not conducted under an IND.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HUMAN SERVICES (CONTINUED) DRUGS FOR HUMAN USE INVESTIGATIONAL NEW DRUG APPLICATION Miscellaneous § 312... the act or section 351 of the Public Health Service Act (the PHS Act) (42 U.S.C. 262)) a well-designed... this section, GCP is defined as a standard for the design, conduct, performance, monitoring, auditing...

77 FR 47079 - Notice of Availability of Draft Policy Document for Comment

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-07

... Public Health Service Act (PHS Act) to support the delivery of preventive and primary care services to... section 1861(aa)(4) and section 1905(l)(2)(B) of the Social Security Act, FQHC Look-Alikes do not receive... support the fee and discount schedules based on an individual's ability to pay. When finalized, this PIN...

76 FR 27062 - Biologics Price Competition and Innovation Act of 2009; Options for a User Fee Program for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-10

... under the Public Health Service Act (PHS Act). FDA is requesting input on the identified principles for... adhere to these principles, and performance goals for this program. FDA plans to review the comments... drug marketing applications were submitted each year for FDA review. The number of participants in the...

45 CFR 154.102 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH... of 45 CFR part 158. Health insurance coverage has the meaning given the term in section 2791(b)(1) of the PHS Act. Health insurance issuer has the meaning given the term in section 2791(b)(2) of the PHS...

45 CFR 154.102 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH... of 45 CFR part 158. Health insurance coverage has the meaning given the term in section 2791(b)(1) of the PHS Act. Health insurance issuer has the meaning given the term in section 2791(b)(2) of the PHS...

45 CFR 154.102 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH... of 45 CFR part 158. Health insurance coverage has the meaning given the term in section 2791(b)(1) of the PHS Act. Health insurance issuer has the meaning given the term in section 2791(b)(2) of the PHS...

45 CFR 154.102 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH... of 45 CFR part 158. Health insurance coverage has the meaning given the term in section 2791(b)(1) of the PHS Act. Health insurance issuer has the meaning given the term in section 2791(b)(2) of the PHS...

77 FR 11556 - Pediatric Studies of Meropenem Conducted in Accordance With Section 409I of the Public Health...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-27

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2011-N-0918] Pediatric Studies of Meropenem Conducted in Accordance With Section 409I of the Public Health Service Act... of the Public Health Service Act (PHS Act) and submitted to the Director of the National Institutes...

76 FR 43237 - Patient Protection and Affordable Care Act; Establishment of Consumer Operated and Oriented Plan...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-20

... General OMB Office of Management and Budget PHS Act Public Health Service Act QHP Qualified Health Plan...) performs some of the issuer's management functions under contract or delegation. Thus, CMS would permit a... billing, and case management from a health insurance issuer that existed on July 16, 2009, as long as the...

78 FR 18855 - World Trade Center Health Program Eligibility Requirements for Shanksville, Pennsylvania and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-28

...Title I of the James Zadroga 9/11 Health and Compensation Act of 2010 amended the Public Health Service Act (PHS Act) by adding Title XXXIII, which establishes the World Trade Center (WTC) Health Program. The WTC Health Program is administered by the Director of the National Institute for Occupational Safety and Health (NIOSH), within the Centers for Disease Control and Prevention (CDC), in the Department of Health and Human Services (HHS), and provides medical monitoring and treatment to eligible firefighters and related personnel, law enforcement officers, and rescue, recovery, and cleanup workers who responded to the September 11, 2001, terrorist attacks in New York City, Shanksville, Pennsylvania, and at the Pentagon, and to eligible survivors of the New York City attacks. Section 3311(a)(2)(C) of the PHS Act requires the WTC Program Administrator (Administrator) to develop eligibility criteria for enrollment of Shanksville, Pennsylvania and Pentagon responders. This interim final rule establishes those eligibility criteria.

28 CFR 79.53 - Proof of employment as a miller.

Code of Federal Regulations, 2010 CFR

2010-07-01

... EXPOSURE COMPENSATION ACT Eligibility Criteria for Claims by Uranium Millers § 79.53 Proof of employment as... Service (PHS) in the course of any health studies of uranium workers during or including the period 1942-1990; (2) Records of a uranium worker census performed by the PHS at various times during the period...

78 FR 78968 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-27

... of Strategic Operations and Regulatory Affairs, Division of Regulations Development, Attention... Disclosure and Review Reporting Requirements CMS-724 Medicare/Medicaid Psychiatric Hospital Survey Data Under... Reporting Requirements; Use: Section 1003 of the Affordable Care Act adds a new section 2794 of the PHS Act...

76 FR 14020 - Agency Forms Undergoing Paperwork Reduction Act Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-15

.../2011)--Revision--National Center for Health Statistics (NCHS), Centers for Disease Control and Prevention (CDC). Background and Brief Description Section 306 of the Public Health Service (PHS) Act (42 U.S... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention [30Day-11-0406...

45 CFR 156.235 - Essential community providers.

Code of Federal Regulations, 2013 CFR

2013-10-01

....235 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING STANDARDS RELATED TO EXCHANGES... result of violating Federal law: (1) Health care providers defined in section 340B(a)(4) of the PHS Act...

45 CFR 156.235 - Essential community providers.

Code of Federal Regulations, 2012 CFR

2012-10-01

....235 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING STANDARDS RELATED TO EXCHANGES... result of violating Federal law: (1) Health care providers defined in section 340B(a)(4) of the PHS Act...

45 CFR 146.180 - Treatment of non-Federal governmental plans.

Code of Federal Regulations, 2014 CFR

2014-10-01

....180 Section 146.180 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS REQUIREMENTS FOR THE GROUP HEALTH INSURANCE MARKET Exclusion of Plans and Enforcement... section 2701 of the PHS Act as codified before enactment of the Affordable Care Act. (ii) Special...

45 CFR 156.235 - Essential community providers.

Code of Federal Regulations, 2014 CFR

2014-10-01

....235 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING STANDARDS RELATED TO EXCHANGES... result of violating Federal law: (1) Health care providers defined in section 340B(a)(4) of the PHS Act...

78 FR 67367 - Agency Information Collection Activities; Proposed Collection; Public Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-12

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Health Resources and Services Administration Agency... Reduction Act of 1995), the Health Resources and Services Administration (HRSA) announces plans to submit an... Requirements OMB No. 0915-0307--Revision Abstract: Title XXVI of the Public Health Service (PHS) Act, as...

Discontinuation of approval of modifications in notes, guaranteed under Title VI or VII of the Public Health Service Act, proposed to permit use of the notes as collateral for tax-exempt financings--PHS. Final rule.

PubMed

1983-09-21

The Department of Health and Human Services (HHS) adds a new section to regulations for making and guaranteeing loans for construction and modernization of hospitals and medical facilities and to regulations for guaranteeing loans for the construction of teaching facilities for health professions personnel. Under these regulations HHS will not approve the modification of the terms of an existing loan guaranteed under Title VI or Title VII of the Public Health Service (PHS) Act if the modification would permit use of the guarantee (or guaranteed loan) as collateral for tax-exempt financing.

78 FR 12833 - Patient Protection and Affordable Care Act; Standards Related to Essential Health Benefits...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-25

... in 2014, all non-grandfathered health insurance coverage in the individual and small group markets... PHS Act directs non-grandfathered group health plans to ensure that cost- sharing under the plan does... individual and small group markets, and not to Medicaid benchmark or benchmark-equivalent plans. In a...

76 FR 29243 - Agency Forms Undergoing Paperwork Reduction Act Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-20

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention [30Day-11-11BF... interstate control of communicable diseases in humans (42 CFR part 70). To perform these tasks in a... (PHS) Act (42 U.S.C. 264) authorizes the Secretary of Health and Human Services to make and enforce...

78 FR 65045 - Patient Protection and Affordable Care Act; Program Integrity: Exchange, Premium Stabilization...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-30

.... Definitions (Sec. 144.103) B. Part 147--Health Insurance Reform Requirements for the Group and Individual... Risk Adjustment Methodology 5. Subpart E--Health Insurance Issuer and Group Health Plan Standards... (PHS Act) relating to health insurance issuers in the group and individual markets and to group health...

77 FR 26020 - Ryan White HIV/AIDS Program Solicitation of Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-02

... HIV/AIDS Program Solicitation of Comments AGENCY: Health Resources and Services Administration (HRSA... solicits comments on Parts A through F of the Ryan White HIV/AIDS Program. Comments are solicited to inform... Public Health Service Act (PHS), as amended by the Ryan White HIV/AIDS Treatment Extension Act of 2009...

21 CFR 115.50 - Refrigeration of shell eggs held for retail distribution.

Code of Federal Regulations, 2010 CFR

2010-04-01

... SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION SHELL EGGS § 115.50 Refrigeration of shell eggs held for... section. (d) Under sections 311 and 361 of the Public Health Service Act (PHS Act), any State or locality... eggs; (D) A statement that these eggs shall not be sold, distributed, or otherwise disposed of or moved...

21 CFR 115.50 - Refrigeration of shell eggs held for retail distribution.

Code of Federal Regulations, 2011 CFR

2011-04-01

... SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION SHELL EGGS § 115.50 Refrigeration of shell eggs held for... section. (d) Under sections 311 and 361 of the Public Health Service Act (PHS Act), any State or locality... eggs; (D) A statement that these eggs shall not be sold, distributed, or otherwise disposed of or moved...

21 CFR 101.17 - Food labeling warning, notice, and safe handling statements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION FOOD LABELING General Provisions § 101.17 Food labeling..., or are sold for use in food service establishments, may be provided on cartons or in labeling, e.g... the Public Health Service Act (PHS Act), any State or locality that is willing and able to assist the...

42 CFR 54a.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... TITLE V OF THE PUBLIC HEALTH SERVICE ACT, 42 U.S.C. 290aa, et seq., FOR SUBSTANCE ABUSE PREVENTION AND... of the PHS Act, 42 U.S.C. 290aa, et seq., for the provision of substance abuse prevention and or... beneficiary means an individual who receives substance abuse services under a program funded in whole or in...

42 CFR 54a.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... TITLE V OF THE PUBLIC HEALTH SERVICE ACT, 42 U.S.C. 290aa, ET SEQ., FOR SUBSTANCE ABUSE PREVENTION AND... of the PHS Act, 42 U.S.C. 290aa, et seq., for the provision of substance abuse prevention and or... beneficiary means an individual who receives substance abuse services under a program funded in whole or in...

42 CFR 54a.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... TITLE V OF THE PUBLIC HEALTH SERVICE ACT, 42 U.S.C. 290aa, et seq., FOR SUBSTANCE ABUSE PREVENTION AND... of the PHS Act, 42 U.S.C. 290aa, et seq., for the provision of substance abuse prevention and or... beneficiary means an individual who receives substance abuse services under a program funded in whole or in...

42 CFR 54a.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... TITLE V OF THE PUBLIC HEALTH SERVICE ACT, 42 U.S.C. 290aa, ET SEQ., FOR SUBSTANCE ABUSE PREVENTION AND... of the PHS Act, 42 U.S.C. 290aa, et seq., for the provision of substance abuse prevention and or... beneficiary means an individual who receives substance abuse services under a program funded in whole or in...

76 FR 54969 - Rate Increase Disclosure and Review: Definitions of “Individual Market” and “Small Group Market”

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-06

... definitions of individual and small group market. This final rule also updates standards for health insurance... Health Service Act (PHS Act) relating to group health plans and health insurance issuers in the group and... health insurance coverage.'' The statute provides that health insurance issuers must submit to the...

77 FR 60441 - Pediatric Studies of Sodium Nitroprusside Conducted in Accordance With Section 409I of the Public...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-03

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-N-0284] Pediatric Studies of Sodium Nitroprusside Conducted in Accordance With Section 409I of the Public Health... accordance with the Public Health Service Act (the PHS Act) and submitted to the Director of the National...

75 FR 37187 - Patient Protection and Affordable Care Act: Preexisting Condition Exclusions, Lifetime and Annual...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-28

... 147.108) generally apply for plan years beginning on or after January 1, 2014, except that in the case... the case of enrollees who are under 19 years of age, these interim final regulations under PHS Act... to the Department of Labor, identified by RIN 1210-AB43, by one of the following methods: Federal e...

World Trade Center Health Program requirements for the addition of new WTC-related health conditions. Final rule.

PubMed

2012-04-25

Title I of the James Zadroga 9/11 Health and Compensation Act of 2010 amended the Public Health Service Act (PHS Act) to establish the World Trade Center (WTC) Health Program. Sections 3311, 3312, and 3321 of Title XXXIII of the PHS Act require that the WTC Program Administrator develop regulations to implement portions of the WTC Health Program established within the Department of Health and Human Services (HHS). The WTC Health Program, which is administered by the Director of the National Institute for Occupational Safety and Health (NIOSH), within the Centers for Disease Control and Prevention (CDC), provides medical monitoring and treatment to eligible firefighters and related personnel, law enforcement officers, and rescue, recovery and cleanup workers who responded to the September 11, 2001, terrorist attacks in New York City, Shanksville, PA, and at the Pentagon, and to eligible survivors of the New York City attacks. This final rule establishes the processes by which the WTC Program Administrator may add a new condition to the list of WTC-related health conditions through rulemaking, including a process for considering petitions by interested parties to add a new condition.

42 CFR 493.602 - Scope of subpart.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS General Administration § 493.602 Scope of subpart. This... (the PHS Act) and the Federal validation of accredited laboratories and of CLIA-exempt laboratories...

42 CFR 493.602 - Scope of subpart.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS General Administration § 493.602 Scope of subpart. This... (the PHS Act) and the Federal validation of accredited laboratories and of CLIA-exempt laboratories...

21 CFR 1271.10 - Are my HCT/P's regulated solely under section 361 of the PHS Act and the regulations in this part...

Code of Federal Regulations, 2010 CFR

2010-04-01

...) REGULATIONS UNDER CERTAIN OTHER ACTS ADMINISTERED BY THE FOOD AND DRUG ADMINISTRATION HUMAN CELLS, TISSUES... objective intent; (3) The manufacture of the HCT/P does not involve the combination of the cells or tissues... not have a systemic effect and is not dependent upon the metabolic activity of living cells for its...

Disclosure of information to organ procurement organizations. Interim final rule.

PubMed

2007-08-23

This document amends the Department of Veterans Affairs (VA) regulations to implement section 204 of the Veterans Benefits, Health Care, and Information Technology Act of 2006. This regulatory change will provide authority for VA to provide individually-identifiable VA medical records of veterans or dependents of veterans who are deceased or whose death is imminent to representatives of organ procurement organizations (OPOs) as defined in section 371(b) of the Public Health Service Act (PHS Act), eye banks, and tissue banks to determine whether the patients are suitable potential donors.

45 CFR 146.101 - Basis and scope.

Code of Federal Regulations, 2011 CFR

2011-10-01

... stays in connection with childbirth. Sections 2791 and 2792 of the PHS Act define terms used in the... connection with childbirth. It also sets forth the regulations governing parity between medical/surgical...

45 CFR 146.101 - Basis and scope.

Code of Federal Regulations, 2013 CFR

2013-10-01

... stays in connection with childbirth. Sections 2791 and 2792 of the PHS Act define terms used in the... connection with childbirth. It also sets forth the regulations governing parity between medical/surgical...

45 CFR 146.101 - Basis and scope.

Code of Federal Regulations, 2012 CFR

2012-10-01

... stays in connection with childbirth. Sections 2791 and 2792 of the PHS Act define terms used in the... connection with childbirth. It also sets forth the regulations governing parity between medical/surgical...

45 CFR 146.101 - Basis and scope.

Code of Federal Regulations, 2014 CFR

2014-10-01

... stays in connection with childbirth. Sections 2791 and 2792 of the PHS Act define terms used in the... to coverage for hospital stays in connection with childbirth. It also sets forth the regulations...

42 CFR 67.16 - Evaluation and disposition of application.

Code of Federal Regulations, 2010 CFR

2010-10-01

... factors: (1) The degree to which the purposes of Title IX of the PHS Act and section 1142 of the Social... demonstrated business management capability of the applicant; (7) The demonstrated competence and skill of the...

Are the Affordable Care Act Restrictions Warranted? A Contemporary Statewide Analysis of Physician-Owned Hospitals.

PubMed

Lundgren, Daniel K; Courtney, Paul M; Lopez, Joshua A; Kamath, Atul F

2016-09-01

The Affordable Care Act placed a moratorium on physician-owned hospital (POH) expansion. Concern exists that POHs increase costs and target healthier patients. However, limited historical data support these claims and are not weighed against contemporary measures of quality and patient satisfaction. The purpose of this study was to investigate the quality, costs, and efficiency across hospital types. One hundred forty-five hospitals in a single state were analyzed: 8 POHs; 16 proprietary hospitals (PHs); and 121 general, full-service acute care hospitals (ACHs). Multiyear data from the Centers for Medicare and Medicaid Services Medicare Cost Report and the statewide Health Care Cost Containment Council were analyzed. ACHs had a higher percentage of Medicare patients as a share of net patient revenue, with similar Medicare volume. POHs garnered significantly higher patient satisfaction: mean Hospital Consumer Assessment of Healthcare Providers and Systems summary rating was 4.86 (vs PHs: 2.88, ACHs: 3.10; P = .002). POHs had higher average total episode spending ($22,799 vs PHs: $18,284, ACHs: $18,856), with only $1435 of total spending on post-acute care (vs PHs: $3867, ACHs: $3378). Medicare spending per beneficiary and Medicare spending per beneficiary performance rates were similar across all hospital types, as were complication and readmission rates related to hip or knee surgery. POHs had better patient satisfaction, with higher total costs compared to PHs and ACHs. A focus on efficiency, patient satisfaction, and ratio of inpatient-to-post-acute care spending should be weighted carefully in policy decisions that might impact access to quality health care. Copyright © 2016 Elsevier Inc. All rights reserved.

Privacy Act of 1974; altered system of records--PHS. Notification of altered system of records: 09-30-0036, "Alcohol, Drug Abuse, and Mental Health Epidemiologic and Biometric Research Data, HHS/ADAMHA/OA".

PubMed

1984-10-23

In accordance with the requirements of the Privacy Act, the Public Health Service (OHS) is publishing a notice of proposal to alter the system of records in the Alcohol, Drug Abuse, and Mental Health Administration (ADAMHA), National Institute of Mental Health (NIMH), entitled, "Mental Health Epidemiologic and Biometric Research Data, HHS/ADAMHA/NIMH," to create an umbrella system of records to include epidemiologic and biometric research data in the areas of alcohol and drug abuse in addition to data already collected and maintained for mental health research. The system is to be retitled, "Alcohol, Drug Abuse, and Mental Health Epidemiologic and Biometric Research Data, HHS/ADAMHA/OA." PHS invites interested persons to submit comments on the proposed alteration on or before November 23, 1984.

42 CFR 417.165 - Reapplication for qualification.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SERVICES (CONTINUED) MEDICARE PROGRAM HEALTH MAINTENANCE ORGANIZATIONS, COMPETITIVE MEDICAL PLANS, AND HEALTH CARE PREPAYMENT PLANS Continued Regulation of Federally Qualified Health Maintenance Organizations... CMS for purposes of section 1310 of the PHS Act may, after completing the corrective action required...

76 FR 38913 - World Trade Center Health Program Requirements for Enrollment, Appeals, Certification of Health...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-01

...Title I of the James Zadroga Health and Compensation Act of 2010 amended the Public Health Service Act (PHS Act) by adding Title XXXIII, which establishes the World Trade Center (WTC) Health Program. Sections 3311, 3312, and 3321 of Title XXXIII of the PHS Act require that the WTC Program Administrator develop regulations to implement portions of the WTC Health Program established within the Department of Health and Human Services (HHS). The WTC Health Program, which will be administered in part by the Director of the National Institute for Occupational Safety and Health (NIOSH), within the Centers for Disease Control and Prevention (CDC), will provide medical monitoring and treatment to eligible firefighters and related personnel, law enforcement officers, and rescue, recovery and cleanup workers who responded to the September 11, 2001, terrorist attacks in New York City, Shanksville, PA, and at the Pentagon, and to eligible survivors of the New York City attacks. This interim final rule establishes the processes by which eligible responders and survivors may apply for enrollment in the WTC Health Program, obtain health monitoring and treatment for WTC-related health conditions, and appeal enrollment and treatment decisions. This interim final rule also establishes a process for the certification of health conditions, and reimbursement rates for providers who provide initial health evaluations, treatment, and health monitoring.

45 CFR 154.101 - Basis and scope.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH... scope. (a) Basis. This part implements section 2794 of the Public Health Service (PHS) Act. (b) Scope. This part establishes the requirements for health insurance issuers offering health insurance coverage...

45 CFR 154.101 - Basis and scope.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH... scope. (a) Basis. This part implements section 2794 of the Public Health Service (PHS) Act. (b) Scope. This part establishes the requirements for health insurance issuers offering health insurance coverage...

45 CFR 154.101 - Basis and scope.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH... scope. (a) Basis. This part implements section 2794 of the Public Health Service (PHS) Act. (b) Scope. This part establishes the requirements for health insurance issuers offering health insurance coverage...

45 CFR 154.101 - Basis and scope.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH... scope. (a) Basis. This part implements section 2794 of the Public Health Service (PHS) Act. (b) Scope. This part establishes the requirements for health insurance issuers offering health insurance coverage...

77 FR 45357 - Delegation of Authority; International Cooperation

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-31

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Delegation of... for Global Health, Centers for Disease Control and Prevention (CDC) without authority to redelegate, the authority vested in the Director, CDC, under section 307 of the Public Health Service (PHS) Act...

42 CFR 67.20 - Confidentiality.

Code of Federal Regulations, 2013 CFR

2013-10-01

... activities under this subpart is protected by section 903(c) of the PHS Act. Specifically: (a) No information... 42 Public Health 1 2013-10-01 2013-10-01 false Confidentiality. 67.20 Section 67.20 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING AGENCY...

42 CFR 67.104 - Confidentiality.

Code of Federal Regulations, 2013 CFR

2013-10-01

... protected by section 903(c) of the PHS Act. Specifically: (a) No information obtained in the course of... 42 Public Health 1 2013-10-01 2013-10-01 false Confidentiality. 67.104 Section 67.104 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING...

42 CFR 67.104 - Confidentiality.

Code of Federal Regulations, 2011 CFR

2011-10-01

... protected by section 903(c) of the PHS Act. Specifically: (a) No information obtained in the course of... 42 Public Health 1 2011-10-01 2011-10-01 false Confidentiality. 67.104 Section 67.104 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING...

42 CFR 67.104 - Confidentiality.

Code of Federal Regulations, 2014 CFR

2014-10-01

... protected by section 903(c) of the PHS Act. Specifically: (a) No information obtained in the course of... 42 Public Health 1 2014-10-01 2014-10-01 false Confidentiality. 67.104 Section 67.104 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING...

42 CFR 67.20 - Confidentiality.

Code of Federal Regulations, 2011 CFR

2011-10-01

... activities under this subpart is protected by section 903(c) of the PHS Act. Specifically: (a) No information... 42 Public Health 1 2011-10-01 2011-10-01 false Confidentiality. 67.20 Section 67.20 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING AGENCY...

42 CFR 67.20 - Confidentiality.

Code of Federal Regulations, 2014 CFR

2014-10-01

... activities under this subpart is protected by section 903(c) of the PHS Act. Specifically: (a) No information... 42 Public Health 1 2014-10-01 2014-10-01 false Confidentiality. 67.20 Section 67.20 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING AGENCY...

42 CFR 67.104 - Confidentiality.

Code of Federal Regulations, 2012 CFR

2012-10-01

... protected by section 903(c) of the PHS Act. Specifically: (a) No information obtained in the course of... 42 Public Health 1 2012-10-01 2012-10-01 false Confidentiality. 67.104 Section 67.104 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING...

42 CFR 67.20 - Confidentiality.

Code of Federal Regulations, 2012 CFR

2012-10-01

... activities under this subpart is protected by section 903(c) of the PHS Act. Specifically: (a) No information... 42 Public Health 1 2012-10-01 2012-10-01 false Confidentiality. 67.20 Section 67.20 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING AGENCY...

42 CFR 67.20 - Confidentiality.

Code of Federal Regulations, 2010 CFR

2010-10-01

... activities under this subpart is protected by section 903(c) of the PHS Act. Specifically: (a) No information... 42 Public Health 1 2010-10-01 2010-10-01 false Confidentiality. 67.20 Section 67.20 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING AGENCY...

42 CFR 417.166 - Waiver of assurances.

Code of Federal Regulations, 2010 CFR

2010-10-01

... (CONTINUED) MEDICARE PROGRAM HEALTH MAINTENANCE ORGANIZATIONS, COMPETITIVE MEDICAL PLANS, AND HEALTH CARE... law; or (2) The HMO shows good cause, consistent with the purposes of title XIII of the PHS Act. (b... the reorganization can only be approved with the waiver of the assurances. (ii) State laws governing...

45 CFR 800.115 - Level playing field.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 3 2013-10-01 2013-10-01 false Level playing field. 800.115 Section 800.115 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF PERSONNEL MANAGEMENT MULTI...) Non-discrimination. Comply with section 2705 of the PHS Act; (e) Quality improvement and reporting...

Biostimulant Action of Protein Hydrolysates: Unraveling Their Effects on Plant Physiology and Microbiome

PubMed Central

Colla, Giuseppe; Hoagland, Lori; Ruzzi, Maurizio; Cardarelli, Mariateresa; Bonini, Paolo; Canaguier, Renaud; Rouphael, Youssef

2017-01-01

Plant-derived protein hydrolysates (PHs) have gained prominence as plant biostimulants because of their potential to increase the germination, productivity and quality of a wide range of horticultural and agronomic crops. Application of PHs can also alleviate the negative effects of abiotic plant stress due to salinity, drought and heavy metals. Recent studies aimed at uncovering the mechanisms regulating these beneficial effects indicate that PHs could be directly affecting plants by stimulating carbon and nitrogen metabolism, and interfering with hormonal activity. Indirect effects could also play a role as PHs could enhance nutrient availability in plant growth substrates, and increase nutrient uptake and nutrient-use efficiency in plants. Moreover, the beneficial effects of PHs also could be due to the stimulation of plant microbiomes. Plants are colonized by an abundant and diverse assortment of microbial taxa that can help plants acquire nutrients and water and withstand biotic and abiotic stress. The substrates provided by PHs, such as amino acids, could provide an ideal food source for these plant-associated microbes. Indeed, recent studies have provided evidence that plant microbiomes are modified by the application of PHs, supporting the hypothesis that PHs might be acting, at least in part, via changes in the composition and activity of these microbial communities. Application of PHs has great potential to meet the twin challenges of a feeding a growing population while minimizing agriculture’s impact on human health and the environment. However, to fully realize the potential of PHs, further studies are required to shed light on the mechanisms conferring the beneficial effects of these products, as well as identify product formulations and application methods that optimize benefits under a range of agro-ecological conditions. PMID:29312427

78 FR 28023 - National Vaccine Injury Compensation Program; List of Petitions Received

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-13

...The Health Resources and Services Administration (HRSA) is publishing this notice of petitions received under the National Vaccine Injury Compensation Program (``the Program''), as required by Section 2112(b)(2) of the Public Health Service (PHS) Act, as amended. While the Secretary of Health and Human Services is named as the respondent in all proceedings brought by the filing of petitions for compensation under the Program, the United States Court of Federal Claims is charged by statute with responsibility for considering and acting upon the petitions.

76 FR 7570 - Proposed Collection; Comment Request; National Institutes of Health Loan Repayment Programs

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-10

...In compliance with the requirement of Section 3506(c)(2)(A) of the Paperwork Reduction Act of 1995, for opportunity for public comment on proposed data collection projects, the Division of Loan Repayment, National Institutes of Health (NIH), will publish periodic summaries of proposed projects to be submitted to the Office of Management and Budget (OMB) for review and approval. Proposed Collection: Title: National Institutes of Health Loan Repayment Programs. Type of Information Collection Request: Extension of a currently approved collection (OMB No. 0925-0361, expiration date 06/30/11). Form Numbers: NIH 2674-1, NIH 2674-2, NIH 2674-3, NIH 2674- 4, NIH 2674-5, NIH 2674-6, NIH 2674-7, NIH 2674-8, NIH 2674-9, NIH 2674-10, NIH 2674-11, NIH 2674-12, NIH 2674-13, NIH 2674-14, NIH 2674- 15, NIH 2674-16, NIH 2674-17, NIH 2674-18, and NIH 2674-19. Need and Use of Information Collection: The NIH makes available financial assistance, in the form of educational loan repayment, to M.D., PhD, Pharm.D., D.D.S., D.M.D., D.P.M., D.C., and N.D. degree holders, or the equivalent, who perform biomedical or behavioral research in NIH intramural laboratories or as extramural grantees or scientists funded by domestic nonprofit organizations for a minimum of 2 years (3 years for the General Research Loan Repayment Program (LRP)) in research areas supporting the mission and priorities of the NIH. The AIDS Research LRP (AIDS-LRP) is authorized by section 487A of the Public Health Service Act (PHS Act) (42 U.S.C. 288-1), and the Clinical Research LRP for Individuals from Disadvantaged Backgrounds (CR-LRP) is authorized by section 487E (42 U.S.C. 288-5). The General Research LRP (GR-LRP) is authorized by section 487C of the PHS Act (42 U.S.C. 288-3), and the Clinical Research LRP (LRP-CR) is authorized by section 487F (42 U.S.C. 288-5a). The Pediatric Research LRP (PR-LRP) is authorized by section 487F of the PHS Act (42 U.S.C. 288-6), and the Extramural Clinical Research LRP for Individuals from Disadvantaged Backgrounds (ECR-LRP) is authorized by an amendment to section 487E (42 U.S.C. 288-5). The Contraception and Infertility Research LRP (CIR-LRP) is authorized by section 487B of the PHS Act (42 U.S.C. 288-2), and the Health Disparities Research LRP (HD- LRP) is authorized by section 485G (42 U.S.C. 287c-33). The Loan Repayment Programs can repay up to $35,000 per year toward a participant's extant eligible educational loans, directly to financial institutions. The information proposed for collection will be used by the Division of Loan Repayment to determine an applicant's eligibility for participation in the program. Frequency of Response: Initial application and one- or two-year renewal application. Affected Public: Individuals or households, nonprofits, and businesses or other for-profit. Type of Respondents: Physicians, other scientific or medical personnel, and institutional representatives. The annual reporting burden is as follows:

Using a set-aside to encourage the evaluation of public health service programs.

PubMed

Riggin, L J; Shipman, S L; York, R L

1995-03-01

For over 20 years, the secretary of the Department of Health and Human Services (HHS) has had the authority to use up to 1% of the annual Public Health Service (PHS) appropriations for the evaluation of federal health programs. However, recent changes to the Public Health Service Act put not only a ceiling (1%) but also a floor (0.2%) on the funds that the secretary can set aside for evaluation. The changes to the legislation are intended to encourage HHS to dedicate more funds to evaluation, focus the funds set aside for evaluation on studies of PHS program implementation and effectiveness, and regularly report the findings of the evaluations to Congress. These changes respond to concerns raised by the U.S. General Accounting Office in a study of the PHS evaluation set-aside conducted for Congress.

42 CFR 9.1 - Applicability and purpose.

Code of Federal Regulations, 2012 CFR

2012-10-01

... CARE FOR CHIMPANZEES HELD IN THE FEDERALLY SUPPORTED SANCTUARY SYSTEM § 9.1 Applicability and purpose. (a) General. The standards of care set forth in this part apply to the chimpanzee sanctuaries that... chimpanzee sanctuary system authorized by section 481C of the Public Health Service (PHS) Act, as amended (42...

42 CFR 9.1 - Applicability and purpose.

Code of Federal Regulations, 2013 CFR

2013-10-01

... CARE FOR CHIMPANZEES HELD IN THE FEDERALLY SUPPORTED SANCTUARY SYSTEM § 9.1 Applicability and purpose. (a) General. The standards of care set forth in this part apply to the chimpanzee sanctuaries that... chimpanzee sanctuary system authorized by section 481C of the Public Health Service (PHS) Act, as amended (42...

42 CFR 9.1 - Applicability and purpose.

Code of Federal Regulations, 2014 CFR

2014-10-01

... CARE FOR CHIMPANZEES HELD IN THE FEDERALLY SUPPORTED SANCTUARY SYSTEM § 9.1 Applicability and purpose. (a) General. The standards of care set forth in this part apply to the chimpanzee sanctuaries that... chimpanzee sanctuary system authorized by section 481C of the Public Health Service (PHS) Act, as amended (42...

21 CFR 118.12 - Enforcement and compliance.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD... compliance. (a) Authority. This part is established under authority of the Public Health Service Act (the PHS...) A statement that these eggs must not be sold, distributed, or otherwise disposed of or moved except...

21 CFR 118.12 - Enforcement and compliance.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD... compliance. (a) Authority. This part is established under authority of the Public Health Service Act (the PHS...) A statement that these eggs must not be sold, distributed, or otherwise disposed of or moved except...

42 CFR 417.920 - Planning and initial development.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Planning and initial development. 417.920 Section... and initial development. (a) Under section 1304 of the PHS Act, grants and loan guarantees were awarded for projects for planning and initial development of HMOs. (b) Planning projects included projects...

42 CFR 417.934 - Reserve requirement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Reserve requirement. 417.934 Section 417.934 Public... PLANS Administration of Outstanding Loans and Loan Guarantees § 417.934 Reserve requirement. (a) Timing... section 1305 of the PHS Act was required to establish a restricted reserve account on the earlier of the...

42 CFR 24.2 - Allocation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Allocation. 24.2 Section 24.2 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.2 Allocation. (a) The Secretary, within the number authorized in the PHS Act, shall determine the...

42 CFR 24.2 - Allocation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Allocation. 24.2 Section 24.2 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.2 Allocation. (a) The Secretary, within the number authorized in the PHS Act, shall determine the...

42 CFR 24.2 - Allocation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Allocation. 24.2 Section 24.2 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.2 Allocation. (a) The Secretary, within the number authorized in the PHS Act, shall determine the...

42 CFR 24.2 - Allocation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Allocation. 24.2 Section 24.2 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.2 Allocation. (a) The Secretary, within the number authorized in the PHS Act, shall determine the...

42 CFR 24.2 - Allocation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Allocation. 24.2 Section 24.2 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.2 Allocation. (a) The Secretary, within the number authorized in the PHS Act, shall determine the...

45 CFR 148.101 - Basis and purpose.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS REQUIREMENTS FOR THE INDIVIDUAL HEALTH INSURANCE MARKET General Provisions § 148.101 Basis and purpose. This part implements sections 2741 through 2763 and 2791 and 2792 of the PHS Act. Its purpose is to improve access to...

45 CFR 148.101 - Basis and purpose.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS REQUIREMENTS FOR THE INDIVIDUAL HEALTH INSURANCE MARKET General Provisions § 148.101 Basis and purpose. This part implements sections 2741 through 2763 and 2791 and 2792 of the PHS Act. Its purpose is to improve access to...

75 FR 38109 - Notice of Availability of Draft Policy Document for Comment

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-01

... Availability of Draft Policy Document for Comment AGENCY: Health Resources and Services Administration (HRSA... policy source for information on FTCA for Health Center Program grantees funded under section 330 of the Public Health Service (PHS) Act (``section 330''). The Policy Manual is currently posted on the Internet...

42 CFR 417.478 - Requirements of other laws and regulations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... information; (c) Section 1301(c)(8) of the PHS Act, which relates to liability arrangements to protect... 42 Public Health 3 2012-10-01 2012-10-01 false Requirements of other laws and regulations. 417.478 Section 417.478 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN...

21 CFR 1271.10 - Are my HCT/P's regulated solely under section 361 of the PHS Act and the regulations in this part...

Code of Federal Regulations, 2014 CFR

2014-04-01

... primary function; or (ii) The HCT/P has a systemic effect or is dependent upon the metabolic activity of living cells for its primary function, and: (a) Is for autologous use; (b) Is for allogeneic use in a...

21 CFR 1271.10 - Are my HCT/P's regulated solely under section 361 of the PHS Act and the regulations in this part...

Code of Federal Regulations, 2012 CFR

2012-04-01

... primary function; or (ii) The HCT/P has a systemic effect or is dependent upon the metabolic activity of living cells for its primary function, and: (a) Is for autologous use; (b) Is for allogeneic use in a...

21 CFR 1271.10 - Are my HCT/P's regulated solely under section 361 of the PHS Act and the regulations in this part...

Code of Federal Regulations, 2011 CFR

2011-04-01

... primary function; or (ii) The HCT/P has a systemic effect or is dependent upon the metabolic activity of living cells for its primary function, and: (a) Is for autologous use; (b) Is for allogeneic use in a...

21 CFR 1271.10 - Are my HCT/P's regulated solely under section 361 of the PHS Act and the regulations in this part...

Code of Federal Regulations, 2013 CFR

2013-04-01

... primary function; or (ii) The HCT/P has a systemic effect or is dependent upon the metabolic activity of living cells for its primary function, and: (a) Is for autologous use; (b) Is for allogeneic use in a...

77 FR 16244 - Request for Comments on the Update of the Scholarships for Disadvantaged Students Program

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-20

... backgrounds, including students who are members of racial and ethnic minority groups. (PHS Act, Sec. 737(d)(1... social work, professional counseling, marriage and family therapy); and physician assistant training..., including students who are members of racial and ethnic minority groups. Also, the primary care weights are...

75 FR 12545 - Agency Information Collection Activities: Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-16

.../AIDS care and support services that are most severely affected by the HIV/AIDS epidemic, including... Service (PHS) Act). Since the purpose of the Part A MAI is to expand access to medical, health, and social support services for disproportionately impacted racial/ ethnic minority populations living with HIV/AIDS...

45 CFR 148.306 - Basis and scope.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Basis and scope. 148.306 Section 148.306 Public... FOR THE INDIVIDUAL HEALTH INSURANCE MARKET Grants to States for Operation of Qualified High Risk Pools § 148.306 Basis and scope. This subpart implements section 2745 of the Public Health Service Act (PHS...

45 CFR 148.306 - Basis and scope.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Basis and scope. 148.306 Section 148.306 Public... FOR THE INDIVIDUAL HEALTH INSURANCE MARKET Grants to States for Operation of Qualified High Risk Pools § 148.306 Basis and scope. This subpart implements section 2745 of the Public Health Service Act (PHS...

Availability of funds for home health services and training--HRSA.

PubMed

1983-12-19

The Health Resources and Services Administration (HRSA) announces that funds are available for grants and loans for the development and expansion of home health programs and services. Public Law (Pub. L.) 98-139, the Labor, Health and Human Services, and Education Appropriations Act of 1984, signed on October 31, 1983, appropriates $5 million under section 339 of the Public Health Service (PHS) Act (42 U.S.C. 255) to provide home health services and for the training of paraprofessionals to provide home health services. This notice contains information of interest to prospective applicants for such funding.

75 FR 74053 - Proposed Data Collections Submitted for Public Comment and Recommendations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-30

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention [30Day-11-09CL... Questionnaire (SDQ) in the National Health Interview Survey (NHIS)--New--National Center for Health Statistics... of the Public Health Service (PHS) Act (42 U.S.C. 242k), as amended, authorizes that the Secretary of...

76 FR 52475 - Summary of Benefits and Coverage and Uniform Glossary-Templates, Instructions, and Related...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-22

...The Departments of the Health and Human Services, Labor, and the Treasury (the Departments) are simultaneously publishing in the Federal Register this document and proposed regulations (2011 proposed regulations) under the Patient Protection and Affordable Care Act to implement the disclosure for group health plans and health insurance issuers of the summary of benefits and coverage (SBC) and the uniform glossary. This document proposes a template for an SBC; instructions, sample language, and a guide for coverage examples calculations to be used in completing the template; and a uniform glossary that would satisfy the disclosure requirements under section 2715 of the Public Health Service (PHS) Act. Comments are invited on these materials.

Department of Health and Human Services Public Health Services. Notification of a new system of records: Three Mile Island mental health survey, respondent records.

PubMed

1980-10-03

In accordance with the requirements of the Privacy Act, the Public Health Service (PHS) is publishing notice of a proposal to establish a new system of records entitled "Three Mile Island Mental Health Survey, Respondent Records, HHS/ADAMHA/NIMH." The Disaster Assistance and Emergency Mental Health Section, Division of Special Mental Health Programs, National Institute of Mental Health, is responsible for the system. The purpose of the system is to enable the Government to arrange followup study to the currently-funded research project entitled "The Mental Health of Residents Near the Three Mile Island Reactor: A Comparative Study of Selected Groups." PHS invites interested persons to submit comments on the proposed routine uses on or before November 3, 1980.

The Post-9/11 Veterans Educational Assistance Improvements Act of 2010

DTIC Science & Technology

2010-08-02

Administration ( NOAA ) to transfer Post-9/11 GI Bill benefits to their dependents; • require the Secretaries concerned to reimburse the Department of Veterans...the Marine Gunnery Sergeant John David Fry Scholarship within the Post-9/11 GI Bill. The scholarship program provides some Post-9/11 GI Bill...officers of the Public Health Service (PHS) and National Oceanic and Atmospheric Administration ( NOAA ) to transfer Post-9/11 GI Bill benefits to

The Post-9/11 Veterans Educational Assistance Improvements Act of 2010

DTIC Science & Technology

2010-08-13

NOAA ) to transfer Post-9/11 GI Bill benefits to their dependents; • require the Secretaries concerned to reimburse the Department of Veterans...Marine Gunnery Sergeant John David Fry Scholarship within the Post-9/11 GI Bill. The scholarship program provides some Post-9/11 GI Bill benefits to...Service (PHS) and National Oceanic and Atmospheric Administration ( NOAA ) to transfer Post-9/11 GI Bill benefits to dependents.35 Under current law, the

Combined effect of plant sterols and dietary fiber for the treatment of hypercholesterolemia.

PubMed

Castellanos-Jankiewicz, Ashley; Del Bosque-Plata, Laura; Tejero, M Elizabeth

2014-06-01

Hypercholesterolemia is a major contributor for disease burden in both the developed and developing world and an important risk factor for cardiovascular diseases (CVD). Phytosterols (PhS) and dietary fiber (DF) act as low density lipoprotein cholesterol (LDL-C) lowering agents, offering an effective treatment against high blood cholesterol and CVD. The aim of this review was to consider clinical evidence that analyzed the combination of PhS and DF in a cereal carrier for lowering LDL-C. Electronic database searches were carried out to identify peer-reviewed journal articles, from which five intervention studies that combined both components in a cereal carrier were identified and included in the present review. LDL-C lowering effects varied widely among studies, due to large heterogeneity in study design, subject baseline characteristics, length of the interventions, PhS and DF dosage and type of DF used. In relation to a time of intake, three studies suggested a frequency or distribution of the product's consumption during the day, while two studies did not consider this factor. Overall, the selected studies found significant differences on LDL-C concentrations, although not all of them reached the expected outcomes. Future research should be conducted to explore the effect that different types of DF exert on LDL-C when combined with PhS, and to analyze the effect of the product's time of intake in order to suggest an optimal moment of the day for its consumption.

Current good tissue practice for human cell, tissue, and cellular and tissue-based product establishments; inspection and enforcement. Final rule.

PubMed

2004-11-24

The Food and Drug Administration (FDA) is requiring human cell, tissue, and cellular and tissue-based product (HCT/P) establishments to follow current good tissue practice (CGTP), which governs the methods used in, and the facilities and controls used for, the manufacture of HCT/Ps; recordkeeping; and the establishment of a quality program. The agency is also issuing new regulations pertaining to labeling, reporting, inspections, and enforcement that will apply to manufacturers of those HCT/Ps regulated solely under the authority of the Public Health Service Act (PHS Act), and not as drugs, devices, and/or biological products. The agency's actions are intended to improve protection of the public health while keeping regulatory burden to a minimum, which in turn would encourage significant innovation.

Grants for nurse practitioner traineeship programs--PHS. Interim final regulations.

PubMed

1984-08-01

These regulations set forth requirements for grants to schools of nursing, medicine, and public health, to public or nonprofit private hospitals, and to other public or nonprofit private entities to meet the costs of traineeships for training nurse practitioners. A trainee must sign a commitment with the Secretary to practice full-time as a nurse practitioner in a primary medical care health manpower shortage area, designated under section 332 of the Public Health Service Act (the Act), for a period equal to 1 month for each month of traineeship support, after completion of the training. If this obligation is not fulfilled, a trainee must pay back traineeship support. The purpose of these regulations is to respond to the comments on the 1980 interim final regulations and to conform 42 CFR Part 57, Subpart AA, with the Paperwork Reduction Act of 1980, Pub. L. 96-511, and with the Omnibus Budget Reconciliation Act of 1981, Pub. L. 97-35, which requires, among other provisions, that the Secretary provide, by regulation, for the waiver or suspension of the repayment obligation under certain conditions. In addition, other minor changes have been made and Office of Management and Budget (OMB) numbers are cited in those sections which have approved reporting and recordkeeping requirements.

Approval of information collection requirements for the joint interim rules for health insurance portability for group health plans, and the individual market health insurance reform: portability from group to individual coverage; federal rules for access in the individual market; state alternative mechanisms to federal rules--IRS, DOL, HCFA. Interim rules with request for comments; approval of information collection requirements.

PubMed

1997-07-02

On April 8, 1997, the Department of the Treasury, the Department of Labor, and the Department of Health and Human Services (Departments) published joint interim rules governing the access, portability and renewability requirements for group health plans and issuers offering group health insurance coverage in connection with a group health plan. The rules implemented changes made to certain provisions of the Internal Revenue Code of 1986 (Code), the Employee Retirement Income Security Act of 1974 (ERISA), and the Public Health Service Act (PHS Act) enacted as part of the Health Insurance Portability and Accountability Act of 1996 (HIPAA). In the April 8 publication, the Departments submitted the group market information collection requirements, for, among other things, establishing creditable coverage, notice of special enrollment rights, and notice of pre-existing condition exclusion periods, to be Office of Management and Budget (OMB) for emergency review under the Paperwork Reduction Act of 1995 (PRA 95). In addition, on April 8, 1997 the Department of Health and Human Services submitted the HIPAA individual market information collection requirements to OMB for emergency review under the PRA 1995. This document amends the April 8 Federal Register documents to properly display the OMB control numbers.

The Selection of a Marine Artillery Battery Fire Direction Computer System.

DTIC Science & Technology

1982-12-01

yhsical Characteristics: Tbe VI provi-ds s h gen er al physical characteri-sti-cs of the BCS. The total weight of the BCS is based on ti,: eg’±ipment...twenty special fanc -tion keys. Six of the special function keys arc- currently spares and will be programmed -o support the P31 software aiditions...close to the weapon or mounted on the weapon. Phs- ga C aacteri sti cs: Table XIV provides the gen e ral physical charactaristics of the FCC. The act

Privacy Act of 1974; system of records--PHS. Waiver of advance notice period for a new system of records.

PubMed

1983-08-30

FR Doc. 83-18581, appearing at page 31738 in the issue of Monday, July 11, 1983, provided notification of a new system of records proposed by the Health Resources and Services Administration (HRSA). That system is 09-15-0045, "Health Resources and Services Administration Loan Repayment/Debt Management Records System, HHS/HRSA/OA." The document stated that the Public Health Service had requested that the Office of Management and Budget (OMB) grant a waiver of the usual requirement that a system of records not be put into effect until 60 days after the report is sent to OMB and the Congress OMB granted the requested waiver on August 3, 1983. Accordingly, the new system of records, 09-15-0045, became effective upon the date of the waiver except for the routine uses established for the system. They became effective August 11, 1983, following the public comment period. However, in response to a comment received from the responsible oversight committee of the U.S. House of Representatives, we are adding a routine use to permit disclosure of information from these records to the General Accounting Office (GAO) and OMB for auditing financial obligations. We are also modifying one of the existing routine uses. PHS invites interested parties to submit comments on the proposed new routine use on or before September 29, 1983. In accordance with the Debt Collection Act of 1982 (Pub. L. 97-365), we are also adding the "special disclosure" statement. This statement does not require a public comment period.

A unified pathogenesis for kidney diseases, including genetic diseases and cancers, by the protein-homeostasis-system hypothesis.

PubMed

Lee, Kyung-Yil

2017-06-01

Every cell of an organism is separated and protected by a cell membrane. It is proposed that harmony between intercellular communication and the health of an organism is controlled by a system, designated the protein-homeostasis-system (PHS). Kidneys consist of a variety of types of renal cells, each with its own characteristic cell-receptor interactions and producing characteristic proteins. A functional union of these renal cells can be determined by various renal function tests, and harmonious intercellular communication is essential for the healthy state of the host. Injury to a kind of renal cells can impair renal function and induce an imbalance in total body health. Every acute or chronic renal disease has unknown etiologic substances that are responsible for renal cell injury at the molecular level. The immune/repair system of the host should control the etiologic substances acting against renal cells; if this system fails, the disease progresses to end stage renal disease. Each renal disease has its characteristic pathologic lesions where immune cells and immune proteins, such as immunoglobulins and complements, are infiltrated. These immune cells and immune proteins may control the etiologic substances involved in renal pathologic lesions. Also, genetic renal diseases and cancers may originate from a protein deficiency or malfunctioning protein under the PHS. A unified pathogenesis for renal diseases, including acute glomerulonephritis, idiopathic nephrotic syndrome, immunoglobulin A nephropathy, genetic renal diseases such as Alport syndrome, and malignancies such as Wilms tumor and renal cell carcinoma, is proposed using the PHS hypothesis.

Comparison of the Canadian and US Laws, Regulations, Policies, and Systems of Oversight for Animals in Research.

PubMed

Griffin, Gilly; Locke, Paul

2016-05-01

The Canadian and United States' approaches to oversight of animals in research are both based on the "3Rs" principles outlined in Russell and Burch's classic text, The Principles of Humane Experimental Technique. Each country seeks to protect the welfare of animals, while permitting the legitimate goals of scientific research to be attained according to the legal principles, cultures, and strengths and constraints of their jurisprudential and societal traditions. Canada is one of the most decentralized federations in the world, and regulation of activities is based to a great extent on custom and practice. The United States is more hierarchical and, at least with respect to laws governing animal research, more centralized. Accordingly, the Canadian approach is rooted in the concepts of social contracts, with a greater emphasis on guidance and policy and less reliance on legislation. No federal (national) direct legislation of laboratory animal welfare exists, although the federal government uses its criminal and spending authorities to shape behavior. The central feature of the Canadian system is the Canadian Council on Animal Care, which was formed to support universities and government departments involved in animal-based science. Animal care committees play a central role in implementing the guidelines and policies in facilities that carry out animal research. The United States has enacted two federal (national) laws applicable to animals in research. The Animal Welfare Act is a more traditional, command-and-control law that gives authority to the US Department of Agriculture to promulgate regulations, inspect facilities, and enforce violations. The Health Research Extension Act, which amended the US Public Health Services (PHS) Act, applies to any activity conducted or supported by the PHS, including research efforts supported by the US National Institutes of Health. It is largely nonregulatory and establishes a system of assurances and policies that covered research facilities must follow. States play only a minor role in animal research protection. As in Canada, institutional animal care and use committees are tasked with self-regulation of activities that use animals for research. © The Author 2017. Published by Oxford University Press on behalf of the Institute for Laboratory Animal Research. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Synthesis of a single 1,8-naphthalimide fluorophore as a molecular logic lab for simultaneously detecting of Fe3+, Hg2+ and Cu2+

NASA Astrophysics Data System (ADS)

Said, Awad I.; Georgiev, Nikolai I.; Bojinov, Vladimir B.

2018-05-01

A novel fluorescence sensing 1,8-naphthalimide fluorophore is synthesized and investigated. The novel probe comprising two different binding moieties is capable to detect selectively Fe3+ over the other representative metal ions as well as a combination of biologically important cations such as Fe3+, Cu2+ and Hg2+ in the physiological range without an interfering effect of the pHs. Due to the remarkable fluorescence changes in the presence of Fe3+, Hg2+ and Cu2+ ions, INH and AND logic gates are executed and the system is able to act as a single output combinatorial logic circuit with three chemical inputs.

Photo-Fenton-assisted ozonation of p-Coumaric acid in aqueous solution.

PubMed

Monteagudo, J M; Carmona, M; Durán, A

2005-08-01

The degradation of p-Coumaric acid present in olive oil mill wastewater was investigated as a pretreatment stage to obtain more easily biodegradable molecules, with lower toxicity that facilitates subsequent anaerobic digestion. Thus, photo-Fenton-assisted ozonation has been studied and compared with ozonation at alkaline pH and conventional single ultraviolet (UV) and acid ozonation treatments. In the combined process, the overall kinetic rate constant was split into various components: direct oxidation by UV light, direct oxidation by ozone and oxidation by hydroxyl radicals. Molecular and/or radical ozone reaction was studied by conducting the reaction in the presence and absence of tert-butylalcohol at pHs 2, 7 and 9. Ozone oxidation rate increases with pH or by the addition of Fenton reagent and/or UV radiation due to generation of hydroxyl radicals, *OH. Hydrogen peroxide and ferrous ion play a double role during oxidation since at low concentrations they act as initiators of hydroxyl radicals but at high concentrations they act as radical scavengers. Finally, the additional levels of degradation by formation of hydroxyl radicals have been quantified in comparison to the conventional single processes and an equation is proposed for the reaction rate as a function of studied operating variables.

Sequence analysis of the phs operon in Salmonella typhimurium and the contribution of thiosulfate reduction to anaerobic energy metabolism.

PubMed Central

Heinzinger, N K; Fujimoto, S Y; Clark, M A; Moreno, M S; Barrett, E L

1995-01-01

The phs chromosomal locus of Salmonella typhimurium is essential for the dissimilatory anaerobic reduction of thiosulfate to hydrogen sulfide. Sequence analysis of the phs region revealed a functional operon with three open reading frames, designated phsA, phsB, and phsC, which encode peptides of 82.7, 21.3, and 28.5 kDa, respectively. The predicted products of phsA and phsB exhibited significant homology with the catalytic and electron transfer subunits of several other anaerobic molybdoprotein oxidoreductases, including Escherichia coli dimethyl sulfoxide reductase, nitrate reductase, and formate dehydrogenase. Simultaneous comparison of PhsA to seven homologous molybdoproteins revealed numerous similarities among all eight throughout the entire frame, hence, significant amino acid conservation among molybdoprotein oxidoreductases. Comparison of PhsB to six other homologous sequences revealed four highly conserved iron-sulfur clusters. The predicted phsC product was highly hydrophobic and similar in size to the hydrophobic subunits of the molybdoprotein oxidoreductases containing subunits homologous to phsA and phsB. Thus, phsABC appears to encode thiosulfate reductase. Single-copy phs-lac translational fusions required both anaerobiosis and thiosulfate for full expression, whereas multicopy phs-lac translational fusions responded to either thiosulfate or anaerobiosis, suggesting that oxygen and thiosulfate control of phs involves negative regulation. A possible role for thiosulfate reduction in anaerobic respiration was examined. Thiosulfate did not significantly augment the final densities of anaerobic cultures grown on any of the 18 carbon sources tested. on the other hand, washed stationary-phase cells depleted of ATP were shown to synthesize small amounts of ATP on the addition of the formate and thiosulfate, suggesting that the thiosulfate reduction plays a unique role in anaerobic energy conservation by S typhimurium. PMID:7751291

The "PHS Increased Risk" Label Is Associated With Nonutilization of Hundreds of Organs per Year.

PubMed

Volk, Michael L; Wilk, Amber R; Wolfe, Cameron; Kaul, Daniel R

2017-07-01

The Public Health Service "Increased Risk" (PHS IR) designation identifies donors at increased risk of transmitting hepatitis B, C, and human immunodeficiency virus. Although the risk remains very low in the era of nucleic acid testing, we hypothesized that this label may result in decreased organ utilization. Organ Procurement and Transplantation Network data were used to compare utilization rates between PHS-IR and non-PHS-IR donors, as well as to compare export rates and variation in utilization. Among adult standard criteria donors between 2010 and 2013 with a known PHS-IR status, covariate-adjusted utilization rates were lower among PHS-IR donors than non-PHS-IR donors for all organs. For example, 4073 (76.7%) of 5314 PHS-IR kidneys were used, compared with 25 490 (83.7%) of 30 456 non-PHS-IR kidneys-an absolute difference of 7%. Furthermore, all PHS-IR organs had higher export rates than non-PHS-IR organs. For example, 28.7% of PHS-IR kidneys were exported versus 19.7% of non-PHS-IR kidneys. Finally, the utilization rate of PHS-IR organs varied by Donation Service Area; utilization ranged from 20% to 100% among adult kidneys, suggesting significant variation in practices. Similar patterns were seen among pediatric donors. Based on the covariate-adjusted model, if the PHS-IR label did not exist, there could be an additional 313 transplants performed in the United States each year. The PHS "increased risk" label appears to be associated with nonutilization of hundreds of organs per year, despite the very low risk of disease transmission. Better tools are needed to communicate the magnitude of risk to patients and their families.

42 CFR 93.221 - PHS support.

Code of Federal Regulations, 2011 CFR

2011-10-01

... PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS... MISCONDUCT Definitions § 93.221 PHS support. PHS support means PHS funding, or applications or proposals... related to that research or training, that may be provided through: Funding for PHS intramural research...

42 CFR 93.221 - PHS support.

Code of Federal Regulations, 2012 CFR

2012-10-01

... PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS... MISCONDUCT Definitions § 93.221 PHS support. PHS support means PHS funding, or applications or proposals... related to that research or training, that may be provided through: Funding for PHS intramural research...

42 CFR 93.221 - PHS support.

Code of Federal Regulations, 2013 CFR

2013-10-01

... PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS... MISCONDUCT Definitions § 93.221 PHS support. PHS support means PHS funding, or applications or proposals... related to that research or training, that may be provided through: Funding for PHS intramural research...

42 CFR 93.221 - PHS support.

Code of Federal Regulations, 2010 CFR

2010-10-01

... PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS... MISCONDUCT Definitions § 93.221 PHS support. PHS support means PHS funding, or applications or proposals... related to that research or training, that may be provided through: Funding for PHS intramural research...

42 CFR 93.221 - PHS support.

Code of Federal Regulations, 2014 CFR

2014-10-01

... PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS... MISCONDUCT Definitions § 93.221 PHS support. PHS support means PHS funding, or applications or proposals... related to that research or training, that may be provided through: Funding for PHS intramural research...

Fractures, Faults, and Hydrothermal Systems of Puna, Hawaii, and Montserrat, Lesser Antilles

NASA Astrophysics Data System (ADS)

Kenedi, Catherine Lewis

The focus of this work is to use geologic and geophysical methods to better understand the faults and fracture systems at Puna, in southeastern Hawaii, and southern Montserrat, in the Lesser Antilles. The particular interest is understanding and locating the deep fracture networks that are necessary for fluid circulation in hydrothermal systems. The dissertation first presents a study in which identification of large scale faulting places Montserrat into a tectonic context. Then follow studies of Puna and Montserrat that focus on faults and fractures of the deep hydrothermal systems. The first chapter consists of the results of the SEA-CALIPSO experiment seismic reflection data, recorded on a 48 channel streamer with the active source as a 2600 in3 airgun. This chapter discusses volcaniclastic debris fans off the east coast of Montserrat and faults off the west coast. The work places Montserrat in a transtensional environment (influenced by oblique subduction) as well as in a complex local stress regime. One conclusion is that the stress regime is inconsistent with the larger arc due to the influence of local magmatism and stress. The second chapter is a seismic study of the Puna hydrothermal system (PHS) along the Kilauea Lower East Rift Zone. The PHS occurs at a left step in the rift, where a fracture network has been formed between fault segments. It is a productive geothermal field, extracting steam and reinjecting cooled, condensed fluids. A network of eight borehole seismometers recorded >6000 earthquakes. Most of the earthquakes are very small (< M.2), and shallow (1-3 km depth), likely the result of hydrothermal fluid reinjection. Deeper earthquakes occur along the rift as well as along the south-dipping fault plane that originates from the rift zone. Seismic methods applied to the PHS data set, after the initial recording, picking, and locating earthquakes, include a tomographic inversion of the P-wave first arrival data. This model indicates a high seismic velocity under the field that is thought to be an intrusion and the heat source of the hydrothermal system. A shear wave splitting study suggested the PHS fracture system is largely oriented rift-parallel with some orthogonal fractures. Shear wave splitting data also were used in a tomographic inversion for fracture density. The fracture density is high in the PHS, which indicates high permeability and potential for extensive fluid circulation. This has been confirmed by high fluid flow and energy generation. The high fracture density is consistent with the interpretation of a transfer zone between the rift segments where a fracture mesh would be expected. In Puna the transfer zone is a relay ramp. The results from the PHS are used as an example to examine the proposed hydrothermal system at St. George's Hill, Montserrat. In southern Montserrat, hot springs and fumaroles suggest a deep hydrothermal system heated by local magmatism. A magnetotelluric study obtained resistivity data that suggest focused alteration under southeastern Montserrat that is likely to be along fault segments. Several faults intersect under SGH, making it the probable center of the hydrothermal system. At Puna, and also Krafla, Iceland, where faults interact is an area of increased permeability, acting as a model to be applied to southern Montserrat. The conclusion is that in both Puna and Montserrat large faults interact to produce local areas of stress transfer that lead to fracturing and permeable networks; these networks allow for high-temperature hydrothermal circulation.

Numerical modelling of temporal and spatial patterns of petroleum hydrocarbons concentration in the Bohai Sea.

PubMed

Guo, Weijun; Wu, Guoxiang; Xu, Tiaojian; Li, Xueyan; Ren, Xiaozhong; Hao, Yanni

2018-02-01

The discharge of petroleum hydrocarbons (PHs; ~10,000tons annually) into the Bohai Sea, a shallow inland sea in China, presents a serious threat to the marine environment. To evaluate the effects of PHs pollution and estimate the corresponding environmental capacity, we have developed a genetic algorithm-based coupled hydrodynamic/transport for simulating PHs concentration evolution and distribution from July 2006 to October 2007, with the predicted values being in good agreement with monitoring results. Importantly, the mean PHs concentrations and seasonal concentration variations were primarily determined by external loading, i.e., currents were shown to drive PHs transport, reconfigure local PHs patterns, and increase PHs concentration in water masses, even at large distances from discharge sources. The developed model could realistically simulate PHs distribution and evolution, thus being a useful tool for estimating the seasonal environmental capacity of PHs. Copyright © 2017 Elsevier Ltd. All rights reserved.

QTL mapping of pre-harvest sprouting resistance in a white wheat cultivar Danby.

PubMed

Shao, Mingqin; Bai, Guihua; Rife, Trevor W; Poland, Jesse; Lin, Meng; Liu, Shubing; Chen, Hui; Kumssa, Tadele; Fritz, Allan; Trick, Harold; Li, Yan; Zhang, Guorong

2018-06-02

One major and three minor QTLs for resistance to pre-harvest sprouting (PHS) were identified from a white wheat variety "Danby." The major QTL on chromosome 3A is TaPHS1, and the sequence variation in its promoter region was responsible for the PHS resistance. Additive × additive effects were detected between two minor QTLs on chromosomes 3B and 5A, which can greatly enhance the PHS resistance. Pre-harvest sprouting (PHS) causes significant losses in yield and quality in wheat. White wheat is usually more susceptible to PHS than red wheat. Therefore, the use of none grain color-related PHS resistance quantitative trait loci (QTLs) is essential for the improvement in PHS resistance in white wheat. To identify PHS resistance QTLs in the white wheat cultivar "Danby" and determine their effects, a doubled haploid population derived from a cross of Danby × "Tiger" was genotyped using genotyping-by-sequencing markers and phenotyped for PHS resistance in two greenhouse and one field experiments. One major QTL corresponding to a previously cloned gene, TaPHS1, was consistently detected on the chromosome arm 3AS in all three experiments and explained 21.6-41.0% of the phenotypic variations. A SNP (SNP-222) in the promoter of TaPHS1 co-segregated with PHS in this mapping population and was also significantly associated with PHS in an association panel. Gene sequence comparison and gene expression analysis further confirmed that SNP-222 is most likely the causal mutation in TaPHS1 for PHS resistance in Danby in this study. In addition, two stable minor QTLs on chromosome arms 3BS and 5AL were detected in two experiments with allele effects consistently contributed by Danby, while one minor QTL on 2AS was detected in two environments with contradicted allelic effects. The two stable minor QTLs showed significant additive × additive effects. The results demonstrated that pyramiding those three QTLs using breeder-friendly KASP markers developed in this study could greatly improve PHS resistance in white wheat.

Cloning and Characterization of a Critical Regulator for Preharvest Sprouting in Wheat

PubMed Central

Liu, Shubing; Sehgal, Sunish K.; Li, Jiarui; Lin, Meng; Trick, Harold N.; Yu, Jianming; Gill, Bikram S.; Bai, Guihua

2013-01-01

Sprouting of grains in mature spikes before harvest is a major problem in wheat (Triticum aestivum) production worldwide. We cloned and characterized a gene underlying a wheat quantitative trait locus (QTL) on the short arm of chromosome 3A for preharvest sprouting (PHS) resistance in white wheat using comparative mapping and map-based cloning. This gene, designated TaPHS1, is a wheat homolog of a MOTHER OF FLOWERING TIME (TaMFT)-like gene. RNA interference-mediated knockdown of the gene confirmed that TaPHS1 positively regulates PHS resistance. We discovered two causal mutations in TaPHS1 that jointly altered PHS resistance in wheat. One GT-to-AT mutation generates a mis-splicing site, and the other A-to-T mutation creates a premature stop codon that results in a truncated nonfunctional transcript. Association analysis of a set of wheat cultivars validated the role of the two mutations on PHS resistance. The molecular characterization of TaPHS1 is significant for expediting breeding for PHS resistance to protect grain yield and quality in wheat production. PMID:23821595

Pentahydroxyscirpene—Producing Strains, Formation In Planta, and Natural Occurrence

PubMed Central

Varga, Elisabeth; Wiesenberger, Gerlinde; Fruhmann, Philipp; Malachová, Alexandra; Svoboda, Thomas; Lemmens, Marc; Adam, Gerhard; Berthiller, Franz

2016-01-01

Trichothecenes are a class of structurally diverse mycotoxins with more than 200 naturally occurring compounds. Previously, a new compound, pentahydroxyscirpene (PHS), was reported as a byproduct of a nivalenol producing Fusarium strain, IFA189. PHS contains a hydroxy group at C-8 instead of the keto group of type B trichothecenes. In this work, we demonstrate that IFA189 belongs to the species Fusarium kyushuense using molecular tools. Production of PHS in vitro was also observed for several isolates of other Fusarium species producing nivalenol. Furthermore, we report the formation of 4-acetyl-PHS by F. kyushuense on inoculated rice. Wheat ears of the variety Remus were infected with IFA189 and the in planta production of PHS was confirmed. Natural occurrence of PHS was verified in barley samples from the Czech Republic using a liquid chromatographic-tandem mass spectrometric method validated for this purpose. Toxicity of PHS to wheat ribosomes was evaluated with a coupled in vitro transcription and translation assay, which showed that PHS inhibits protein biosynthesis slightly less than nivalenol and deoxynivalenol. PMID:27754401

Potential Coastal Pumped Hydroelectric Energy Storage Locations Identified using GIS-based Topographic Analysis

NASA Astrophysics Data System (ADS)

Parsons, R.; Barnhart, C. J.; Benson, S. M.

2013-12-01

Large-scale electrical energy storage could accommodate variable, weather dependent energy resources such as wind and solar. Pumped hydroelectric energy storage (PHS) and compressed energy storage area (CAES) have life cycle energy and financial costs that are an order of magnitude lower than conventional electrochemical storage technologies. However PHS and CAES storage technologies require specific geologic conditions. Conventional PHS requires an upper and lower reservoir separated by at least 100 m of head, but no more than 10 km in horizontal distance. Conventional PHS also impacts fresh water supplies, riparian ecosystems, and hydrologic environments. A PHS facility that uses the ocean as the lower reservoir benefits from a smaller footprint, minimal freshwater impact, and the potential to be located near off shore wind resources and population centers. Although technologically nascent, today one coastal PHS facility exists. The storage potential for coastal PHS is unknown. Can coastal PHS play a significant role in augmenting future power grids with a high faction of renewable energy supply? In this study we employ GIS-based topographic analysis to quantify the coastal PHS potential of several geographic locations, including California, Chile and Peru. We developed automated techniques that seek local topographic minima in 90 m spatial resolution shuttle radar topography mission (SRTM) digital elevation models (DEM) that satisfy the following criteria conducive to PHS: within 10 km from the sea; minimum elevation 150 m; maximum elevation 1000 m. Preliminary results suggest the global potential for coastal PHS could be very significant. For example, in northern Chile we have identified over 60 locations that satisfy the above criteria. Two of these locations could store over 10 million cubic meters of water or several GWh of energy. We plan to report a global database of candidate coastal PHS locations and to estimate their energy storage capacity.

An analysis of dormancy, ABA responsiveness, after-ripening and pre-harvest sprouting in hexaploid wheat (Triticum aestivum L.) caryopses.

PubMed

Gerjets, Tanja; Scholefield, Duncan; Foulkes, M John; Lenton, John R; Holdsworth, Michael J

2010-01-01

Embryo and caryopsis dormancy, abscisic acid (ABA) responsiveness, after-ripening (AR), and the disorder pre-harvest sprouting (PHS) were investigated in six genetically related wheat varieties previously characterized as resistant, intermediate, or susceptible to PHS. Timing of caryopsis AR differed between varieties; AR occurred before harvest ripeness in the most PHS-susceptible, whereas AR was slowest in the most PHS-resistant. Whole caryopses of all varieties showed little ABA-responsiveness during AR; PHS-susceptible varieties were responsive at the beginning of the AR period whereas PHS-resistant showed some responsiveness throughout. Isolated embryos showed relatively little dormancy during grain-filling and most varieties exhibited a window of decreased ABA-responsiveness around the period of maximum dry matter accumulation (physiological maturity). Susceptibility to PHS was assessed by overhead misting of either isolated ears or whole plants during AR; varieties were clearly distinguished using both methods. These analyses allowed an investigation of the interactions between the different components of seed development, compartments, and environment for the six varieties. There was no direct relationship between speed of caryopsis AR and embryo dormancy or ABA-responsiveness during seed maturation. However, the velocity of AR of a variety was closely associated with the degree of susceptibility to PHS during AR suggesting that these characters are developmentally linked. Investigation of genetic components of AR may therefore aid breeding approaches to reduce susceptibility to PHS.

Fighting addiction's death row: British Columbia Supreme Court Justice Ian Pitfield shows a measure of legal courage

PubMed Central

2008-01-01

The art in law, like medicine, is in its humanity. Nowhere is the humanity in law more poignant than in BC Supreme Court Justice Ian Pitfield's recent judgment in the legal case aimed at protecting North America's only supervised injection facility (SIF) as a healthcare program: PHS Community Services Society versus the Attorney General of Canada. In order to protect the SIF from politicization, the PHS Community Services Society, the community organization that established and operates the program, along with two people living with addiction and three lawyers working for free, pro bono publico, took the federal government of Canada to court. The courtroom struggle that ensued was akin to a battle between David and Goliath. The judge in the case, Justice Pitfield, ruled in favour of the PHS and gave the Government of Canada one year to bring the Controlled Drugs and Substances Act (CDSA) into compliance with the country's Charter of Rights and Freedoms. If parliament fails to do so, then the CDSA will evaporate from enforceability and law in June of 2009. Despite the fact that there are roughly twelve million intravenous drug addiction users in the world today, politics andprejudice oards harm reduction are still a barrier to the widespread application of the "best medicine" available for serious addicts. Nowhere is this clearer than in the opposition by conservative Prime Minister Stephen Harper and his faithful servant, federal health minister Tony Clement, towards Vancouver's SIF ("Insite"). The continued angry politicization of addiction will only lead to the tragic loss of life, as addicts are condemned to death from infectious diseases (HIV & hepatitis) and preventable overdoses. In light of the established facts in science, medicine and now law, political opposition to life-saving population health programs (including SIFs) to address the effects of addiction is a kind of implicit capital punishment for the addicted. This commentary examines the socio-political context of the legal case and the major figures that contributed to it. It reviews Justice Pitfield's ruling, a judgment that has brought Canada one step closer to putting a stop to addiction's death row where intravenous drug users are needlessly, for political and ideological reasons alone, forced to face increased risks of death due to AIDS, hepatitis and overdose. PMID:18957091

Changing the paradigm of organ utilization from PHS increased-risk donors: an opportunity whose time has come?

PubMed

Sibulesky, Lena; Javed, Imran; Reyes, Jorge D; Limaye, Ajit P

2015-09-01

Approximately 8-11% of all organ donors are classified by Public Health Service (PHS) as increased-risk. The proportion of PHS increased-risk donors is on the rise. At the University of Washington Medical Center, in 2014, the proportion of transplants from PHS increased-risk donors was 28% of liver transplants and 23% of kidney transplants. Nationally, transplant providers have been reluctant to use organs from PHS increased-risk donors because of concern for transmission of HIV, HCV, or HBV. There is also patient apprehension when these organs are being offered, and thus the discard rate of these otherwise good quality organs is high. Because of the organ shortage, preventing underutilization of such organs is essential. We provide data and considerations that should be used to guide the use of organs from PHS increased-risk donors. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Stable isotopes suggest differences in diet between historic and reintroduced Przewalskís horses in the Gobi desert

NASA Astrophysics Data System (ADS)

Burnik Šturm, Martina; Spasskaya, Natalia N.; Sablin, Mikhail V.; Voigt, Christian C.; Kaczensky, Petra

2016-04-01

In historic times, two wild equid species, the Przewalski᾽s horse (PH; Equus ferus przewalskii) and the Asiatic wild ass (khulan, KH; Equus hemionus), roamed the Eurasian steppes. By the end of the 1960s, PHs had been driven to extinction in the wild and the range of KHs became severely restricted to the least productive habitats. However, PHs survived in captivity and reintroductions since the 1990s have brought the species back to parts of its native range in Mongolia and northern China where they again overlap with KHs. Ecological research on PHs and KHs has increased in recent years, but very little information is available on the ecology of the original PHs prior to extinction in the wild. We applied stable isotope analysis (13C, 15N, and 2H) of segmentally cut tail hair of PHs and KHs, collected during expeditions in NW China and SW Mongolia in 1889-1899, to draw inferences about the species feeding ecology. We compared tail hair isotope patterns of historic individuals to those of their extant counterparts from the Mongolian Gobi. A previous study of isotopic tail hair signatures of extant PHs (N=6) and KHs (N=6) suggested species specific differences in diet, with PHs being year-round grazers, but KHs switching between being grazers in summer and mixed feeders in winter (Burnik Šturm et al., in prep.). The comparison of isotope patterns of extant with historic samples confirms diet seasonality in historic KHs (N=3), but detects the same seasonality in five out of six PHs, suggesting that historic PHs had a different isotopic dietary niche than extant PHs. While we are still unable to fully understand the underlying reasons for this change in PHs, our results clearly suggest that the isotopic dietary niche of PHs was wider in the past, suggesting a higher diet flexibility, and overlapped with that of KHs, suggesting a high competition potential over Gobi pastures between the two equid species in historic times. Reference: Burnik Šturm, M., Ganbaatar, O., Voigt, C.C., Kaczensky, P. Stable isotopes reveal differences in the feeding ecology of three sympatric equid species in Dzungarian Gobi, Mongolia (in prep.)

Spatial analysis of ecosystem service relationships to improve targeting of payments for hydrological services

PubMed Central

Manson, Robert H.; Ricketts, Taylor H.; Geissert, Daniel

2018-01-01

Payment for hydrological services (PHS) are popular tools for conserving ecosystems and their water-related services. However, improving the spatial targeting and impacts of PHS, as well as their ability to foster synergies with other ecosystem services (ES), remain challenging. We aimed at using spatial analyses to evaluate the targeting performance of México’s National PHS program in central Veracruz. We quantified the effectiveness of areas targeted for PHS in actually covering areas of high HS provision and social priority during 2003–2013. First, we quantified provisioning and spatial distributions of two target (water yield and soil retention), and one non-target ES (carbon storage) using InVEST. Subsequently, pairwise relationships among ES were quantified by using spatial correlation and overlap analyses. Finally, we evaluated targeting by: (i) prioritizing areas of individual and overlapping ES; (ii) quantifying spatial co-occurrences of these priority areas with those targeted by PHS; (iii) evaluating the extent to which PHS directly contribute to HS delivery; and (iv), testing if PHS targeted areas disproportionately covered areas with high ecological and social priority. We found that modelled priority areas exhibited non-random distributions and distinct spatial patterns. Our results show significant pairwise correlations between all ES suggesting synergistic relationships. However, our analysis showed a significantly lower overlap than expected and thus significant mismatches between PHS targeted areas and all types of priority areas. These findings suggest that the targeting of areas with high HS provisioning and social priority by Mexico’s PHS program could be improved significantly. This study underscores: (1) the importance of using maps of HS provisioning as main targeting criteria in PHS design to channel payments towards areas that require future conservation, and (2) the need for future research that helps balance ecological and socioeconomic targeting criteria. PMID:29462205

Gold nanoparticles bound on microgel particles and their application as an enzyme support

NASA Astrophysics Data System (ADS)

Xu, Jing; Zeng, Fang; Wu, Shuizhu; Liu, Xinxing; Hou, Chao; Tong, Zhen

2007-07-01

Submicron-sized poly(N-isopropyl acrylamide)/polyethyleneimine core-shell microgels were prepared in aqueous media by using tert-butyl hydroperoxide (TBHP) as an initiator, and then the gold nanoparticles (~8 nm) were formed on the surface of the microgels. The amino groups on the polyethyleneimine (PEI) chains act as the binder for the assembly of the gold nanoparticles/microgel complex. In aqueous media the microgels are highly stable with the gold nanoparticles on their extended PEI chains, and this multi-scale nanoparticle complex can be recovered from water and redispersed in water. The nanogold/microgel particles were conjugated with the enzymes horseradish peroxidase (HRP) and urease. It is found that under identical assay conditions the enzyme/nanogold/microgel systems exhibit enhanced biocatalytic activity over free enzymes in solution, especially at lower enzyme concentrations. In addition, compared to free HRP, the HRP/nanogold/microgel systems show higher activity at varied pHs and temperatures, as well as higher storage stability. Thus the novel nanogold/microgel particles can serve as an excellent support for enzymes.

Estimates of genetic parameters in turkeys. 3. Sexual dimorphism and its implications in selection procedures.

PubMed

Toelle, V D; Havenstein, G B; Nestor, K E; Bacon, W L

1990-10-01

Live, carcass, and skeletal data taken at 16 wk of age on 504 female and 584 male turkeys from 34 sires and 168 dams were utilized to evaluate sex differences in genetic parameter estimates. Data were transformed to common mean and variance to evaluate possible scaling effects. Genetic parameters were estimated from transformed and untransformed data. Further analyses were conducted with a model that included sire by sex and dams within sire by sex interactions, and the variance estimates were used to calculate genetic correlations between the sexes and genetic regression parameters. Heritability estimates from transformed and untransformed data were similar, indicating that sex differences were present in the genetic parameters, but scaling effects were not an important factor. Genetic correlation estimates from paternal (PHS) and maternal (MHS) half-sib estimates were close to unity for BW (1.14, PHS; 1.09, MHS), shank width (.99, PHS; .93, MHS), breast muscle weight (1.23, PHS; 1.04, MHS), and shank length (1.09, PHS; .97, MHS). However, abdominal fat (.79, PHS; .59 MHS), total drumstick muscle weight (.75, PHS; 1.14, MHS), rough cleaned shank weight (.78, PHS; not estimatable, MHS), and shank bone density (1.00, PHS; .53, MHS) estimates were somewhat lower. The estimates suggest that the measurement of these latter "traits" at the same age in the two sexes may, in fact, be measuring different genetic effects and that selection procedures in turkeys need to take these correlations into account in order to make optimum progress. The genetic regression parameters indicated that more intense selection in the sex that has the smaller genetic variation could be practiced to make greater gains in the opposite sex.

Metabolic engineering of monoterpene biosynthesis in tomato fruits via introduction of the non-canonical substrate neryl diphosphate.

PubMed

Gutensohn, Michael; Nguyen, Thuong T H; McMahon, Richard D; Kaplan, Ian; Pichersky, Eran; Dudareva, Natalia

2014-07-01

Recently it was shown that monoterpenes in tomato trichomes (Solanum lycopersicum) are synthesized by phellandrene synthase 1 (PHS1) from the non-canonical substrate neryl diphosphate (NPP), the cis-isomer of geranyl diphosphate (GPP). As PHS1 accepts both NPP and GPP substrates forming different monoterpenes, it was overexpressed in tomato fruits to test if NPP is also available in a tissue highly active in carotenoid production. However, transgenic fruits overexpressing PHS1 produced only small amounts of GPP-derived PHS1 monoterpene products, indicating the absence of endogenous NPP. Therefore, NPP formation was achieved by diverting the metabolic flux from carotenoids via expression of tomato neryl diphosphate synthase 1 (NDPS1). NDPS1 transgenic fruits produced NPP-derived monoterpenes, including nerol, neral and geranial, while displaying reduced lycopene content. NDPS1 co-expression with PHS1 resulted in a monoterpene blend, including β-phellandrene, similar to that produced from NPP by PHS1 in vitro and in trichomes. Unexpectedly, PHS1×NDPS1 fruits showed recovery of lycopene levels compared to NDPS1 fruits, suggesting that redirection of metabolic flux is only partially responsible for the reduction in carotenoids. In vitro assays demonstrated that NPP serves as an inhibitor of geranylgeranyl diphosphate synthase, thus its consumption by PHS1 leads to recovery of lycopene levels. Monoterpenes produced in PHS1×NDPS1 fruits contributed to direct plant defense negatively affecting feeding behavior of the herbivore Helicoverpa zea and displaying antifungal activity against Botrytis cinerea. These results show that NPP-derived terpenoids can be produced in plant tissues; however, NPP has to be consumed to avoid negative impacts on plant metabolism. Copyright © 2014 International Metabolic Engineering Society. Published by Elsevier Inc. All rights reserved.

Mutations of genes in synthesis of the carotenoid precursors of ABA lead to pre-harvest sprouting and photo-oxidation in rice

PubMed Central

Fang, Jun; Chai, Chenglin; Qian, Qian; Li, Chunlai; Tang, Jiuyou; Sun, Lei; Huang, Zejun; Guo, Xiaoli; Sun, Changhui; Liu, Min; Zhang, Yan; Lu, Qingtao; Wang, Yiqin; Lu, Congming; Han, Bin; Chen, Fan; Cheng, Zhukuan; Chu, Chengcai

2008-01-01

Pre-harvest sprouting (PHS) or vivipary in cereals is an important agronomic trait that results in significant economic loss. A considerable number of mutations that cause PHS have been identified in several species. However, relatively few viviparous mutants in rice (Oryza sativa L.) have been reported. To explore the mechanism of PHS in rice, we carried out an extensive genetic screening and identified 12 PHS mutants (phs). Based on their phenotypes, these phs mutants were classified into three groups. Here we characterize in detail one of these groups, which contains mutations in genes encoding major enzymes of the carotenoid biosynthesis pathway, including phytoene desaturase (OsPDS), ζ-carotene desaturase (OsZDS), carotenoid isomerase (OsCRTISO) and lycopene β-cyclase (β-OsLCY), which are essential for the biosynthesis of carotenoid precursors of ABA. As expected, the amount of ABA was reduced in all four phs mutants compared with that in the wild type. Chlorophyll fluorescence analysis revealed the occurrence of photoinhibition in the photosystem and decreased capacity for eliminating excess energy by thermal dissipation. The greatly increased activities of reactive oxygen species (ROS) scavenging enzymes, and reduced photosystem (PS) II core proteins CP43, CP47 and D1 in leaves of the Oscrtiso/phs3-1 mutant and OsLCY RNAi transgenic rice indicated that photo-oxidative damage occurred in PS II, consistent with the accumulation of ROS in these plants. These results suggest that the impairment of carotenoid biosynthesis causes photo-oxidation and ABA-deficiency phenotypes, of which the latter is a major factor controlling the PHS trait in rice. PMID:18208525

Reduced 3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy)-Initiated Oxidative DNA Damage and Neurodegeneration in Prostaglandin H Synthase-1 Knockout Mice

PubMed Central

2010-01-01

The neurodegenerative potential of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and underlying mechanisms are under debate. Here, we show that MDMA is a substrate for CNS prostaglandin H synthase (PHS)-catalyzed bioactivation to a free radical intermediate that causes reactive oxygen species (ROS) formation and neurodegenerative oxidative DNA damage. In vitro PHS-1-catalyzed bioactivation of MDMA stereoselectively produced free radical intermediate formation and oxidative DNA damage that was blocked by the PHS inhibitor eicosatetraynoic acid. In vivo, MDMA stereoselectively caused gender-independent DNA oxidation and dopaminergic nerve terminal degeneration in several brain regions, dependent on regional PHS-1 levels. Conversely, MDMA-initiated striatal DNA oxidation, nerve terminal degeneration, and motor coordination deficits were reduced in PHS-1 +/− and −/− knockout mice in a gene dose-dependent fashion. These results confirm the neurodegenerative potential of MDMA and provide the first direct evidence for a novel molecular mechanism involving PHS-catalyzed formation of a neurotoxic MDMA free radical intermediate. PMID:22778832

Cloning and characterization of thermo-alkalistable and surfactant stable endoglucanase from Puga hot spring metagenome of Ladakh (J&K).

PubMed

Gupta, Puneet; Mishra, Arjun K; Vakhlu, Jyoti

2017-10-01

A thermo-alkalistable and surfactant stable endoglucanase (PHS) gene consisting of 554 amino acids was identified from metagenomic library of Puga hot spring using functional screening. PHS gene was overexpressed and purified to homogeneity using affinity chromatography The purified PHS protein presented a single band of 60kDa on the SDS-PAGE gel and zymogram. The recombinant PHS exhibited activity over a broad range of pH and temperature with optima at pH 8.0 and 65°C, respectively and having optimum stability at 60°C and pH 8.0, respectively. The recombinant PHS showed highest substrate specificity using CMC (218.4U/mg) as compared with Barley β-glucan (89.2U/mg) and Avicel (0.8U/mg). The K m and V max of recombinant PHS for CMC were 3.85mg/ml and 370.37μmolmin -1 mg -1 , respectively. The activity of the recombinant PHS was enhanced by treatment with 10mM non-ionic detergents such as Tween 20, Tween 40, Tween 80, Triton X- 100 and PEG and was inhibited by CTAB, SDS. Its functionality was stable in the presence of Fe 3+ but inhibited by Cu 2+ , Hg 2+ , Mn 2+ and Zn 2+ . These properties make PHS endoglucanase a potential candidate for use in laundry, textile,paper and pulp industries. Copyright © 2017 Elsevier B.V. All rights reserved.

Deceased Organ Donors and PHS Risk Identification: Impact on Organ Usage and Outcomes.

PubMed

Pruett, Timothy L; Clark, Marissa A; Taranto, Sarah E

2017-07-01

In 2013, the public health service (PHS) changed the criteria intended to identify organ donors that put the associated organ recipients at increased risk for acquiring human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). The changing donor demographics, organ utilization, and outcomes associated with this change are not known. A review of the Organ Procurement and Transplantation Network database was performed to assess the impact of PHS donor designation on organ utilization and outcomes. After the 2013 modification, over 20% of all deceased organ donors in the United States were identified as PHS increased risk. Compared with the standard risk deceased organ donor, the PHS donor was younger, male, died from anoxia, more likely to be HCV and antibody reacting to hepatitis B core antigen+, and less likely to have diabetes or hypertension. Organs from the 18- to 34-year-old deceased donors with PHS risks (but relatively few medical comorbidities) and tested negative for HCV were less frequently transplanted compared with the standard risk donors (3.9 vs 4.2 organs transplanted per donor). However, the transplant patient and graft survival as well as risk of unexpected transmission of HIV, HBV, and HCV were equivalent, irrespective of PHS donor status. The rationale of using PHS donor designation that negatively impacts utilization of high-quality organs without the benefit of identifying the subset of organs with demonstrable proclivity to transmit HIV, HBV, or HCV needs to be reexamined.

Follow-up study on management of chronic obstructive pulmonary disease in Hunan Province, the People’s Republic of China

PubMed Central

Zeng, Yuqin; Xu, Jianxian; Cai, Shan; Jiang, Fen; Hu, Anmei; Liu, Huayun; Bei, Chengli; Chen, Ping

2016-01-01

Background In 2009, our study showed an extreme imbalance and disparity in COPD-related health resources allocation at three levels of public hospitals (PHs) in Hunan Province of the People’s Republic of China, especially in second-level PHs. Moreover, most Chinese citizens accept their health care services in first- and second-level PHs for economic and geographical reasons, as well as because of the incomplete transfer system in the health care services. To improve diagnosis and treatment ability of pulmonologists in second-level PHs, an intervention that provided training combined with spirometry equipment was carried out in three PHs from six second-level PHs. The aim of this follow-up study was to evaluate the changes associated with COPD-related health resources allocation and the effect of the intervention 4 years later. Methods The data regarding the availability of spirometers, inhalation agents for COPD, and COPD-related health care education for local residents were collected from 57 PHs in 2009 and 48 PHs in 2013. Pulmonologists working in these PHs were asked to complete a questionnaire individually. Six second-level PHs (three in the intervention group and the other three in the control group [without training and spirometry equipment]) that further took part in the survey in 2009 were reevaluated to determine the doubtful diagnostic ratio and the confirmation ratio of COPD. The differences between 2009 and 2013 data was analyzed. Results A total of 762 questionnaires were completed. Compared with 2009, spirometer-equipped ratio raised from 40% to 69% in 2013 (P=0.03). The overall inhalation agent-equipped ratio increased from 58% in 2009 to 88% in 2013 (P=0.001). The total rate of health education raised from 35% in 2009 to 63% in 2013 (P=0.04). In total, 204 pulmonologists from six PHs (selected for study in 2009) completed the questionnaires in 2013. The median score of COPD knowledge questionnaire in the intervention group was higher than that of the control group (80 vs 50, respectively, P<0.01). Further, the clinical doubtful diagnostic ratio (15%) and the diagnosis ratio of COPD (3%) in the intervention group were higher than in the control group (4% and 1%, respectively, P<0.05) even after 4 years. Conclusion COPD-related health resources allocation improved in the 4 years following intervention at three levels of PHs in the People’s Republic of China. Short-term training combined with spirometry equipment had a sustained effect on improving the physicians’ understanding and diagnosis ability of COPD. PMID:27274219

Distribution of slab-derived fluids around the edge of the Philippine Sea Plate from Central to Northeast Japan

NASA Astrophysics Data System (ADS)

Nakamura, Hitomi; Iwamori, Hikaru; Ishizuka, Osamu; Nishizawa, Tatsuji

2018-01-01

Marginal parts of a plate and subducting slab can play important roles in geodynamics. This is because in areas where a plate interacts with other plates or with the mantle thermal, geochemical, and mechanical interactions are expected. The Philippine Sea (PHS) slab that subducts beneath the Japan arcs has such an edge. To examine the relationship between arc magmatism and the slab edge in the transition zone from Northeast Japan to Central Japan, we investigated isotopic systematics of the regional volcanic rocks, incorporating data from literature and new data for five isotopic ratios of Sr, Nd, and Pb. The new data included major element compositions of 22 samples from the back-arc area, and 5 isotopic ratios for 6 samples selected from Pleistocene to early Quaternary epochs. Consequently, several findings were determined based on the spatial variation of the isotopic ratios and the estimated amount of slab-derived fluid: (1) the amount of fluid derived from the two subducting slabs (i.e., the Pacific slab and the PHS slab) decreases northward from a significantly high value ( 5 wt% fluid added to the source mantle), away from the seismically determined edge of the PHS slab; (2) the proportion of the PHS component in the total slab-derived fluid also decays northward; and (3) the PHS component spreads to the north beyond the seismically determined edge of the PHS slab. These observations strongly suggest that the existence of an aseismic PHS slab beneath southernmost parts of Northeast Japan delivers the PHS component to the arc magmatism. As was indicated by previous geodynamical studies, subduction of the PHS and PAC slabs may generate suction force towards the corner of mantle wedge, which might account for the large amount of fluid near the seismically determined slab edge as described in (1) above.

[Preoperational study for the improvement of hygiene conditions in long-term care facilities].

PubMed

Adler, A C; Spegel, H; Kolb, S; Hierl, W; Müller, C; Höller, C; Liebl, B; Rudolph, P; Herr, C

2014-12-01

Hygiene is becoming more and more important in long-term care facilities. Long-term care facilities are subject to monitoring by the Public Health Service (PHS) and other authorities. For the PHS in Bavaria the Bavarian Health and Food Safety Authority (Landesamt für Gesundheit und Lebensmittelsicherheit, LGL) published a hygiene monitoring concept and there exists an inspection guide developed by a specialist department for nursing homes and institutions for the handicapped (Fachstelle für Pflege und Behinderteneinrichtungen, FQA). Because inspections are performed in multiprofessional teams, it makes sense to use a coordinated inspection catalog. The aim was to integrate hygienic requirements specified in the Bavarian guidelines for hygiene by the LGL into the inspection guide published by the FQA to obtain a quality assured surveillance. The involved parties were questioned about the inspection guide and their hygiene management and then the hygiene criteria of the LGL were implemented into the inspection guide. Questions dealing with hygiene requirements concerning intensive care, management of multidrug resistant bacteria and interviews with the person responsible for infection control in the facility itself were developed for the first time and were integrated into the inspection guide. The revised inspection guide was tested for its applicability. With the revised inspection guide there now exists a tool which allows not only comprehensive inspections of the facilities including hygiene issues but also a good cooperation of the various parties involved. There are many actions which have to be conveyed into the future, especially programs to train staff to apply the inspection guide and to enhance the ability of all participants to act in cooperation. The guide will also allow the facilities to cooperate more easily and more closely, as the guide takes the respective problems and challenges of the different facilities into consideration. Additionally the development of legal guidelines regarding hygiene can support general healthcare of residents.

Prolene hernia system compared with mesh plug technique: a prospective study of short- to mid-term outcomes in primary groin hernia repair.

PubMed

Huang, C S; Huang, C C; Lien, H H

2005-05-01

Two types of anterior tension-free hernioplasty, prolene hernia system (PHS) repair and mesh plug technique (MPT), were introduced to Taiwan in 2001. This study compared the short- to mid-term outcomes following primary groin hernia repair with PHS and MPT. From January 2001 to December 2003, 393 patients with 426 primary groin hernias were operated on by a single surgeon using MPT (n=192) and PHS (n=234). Baseline perioperative details and follow-up information were compared. Demographic characteristics of both groups were similar. The laterality, types of anesthesia, postoperative stay, postoperative wound pain scores, wound complications and days to return to activities of daily life were equally distributed between the two groups. However, the distribution of Gilbert types in the PHS group was shifted a little to the right compared with that of the MPT group. PHS repair had longer operative time (34+/-17 vs 25+/-9 minutes, p<0.01). No recurrence was noted in both groups during the follow-up from 5 to 41 months. Chronic non-disabling groin pains were noted in 2.8% (6/218) of patients in the PHS group and 8.9% (14/175) in the MPT group (p=0.01). Our results show that both PHS and MPT repairs can be performed with short operation time, minor wound pain and quick return to activities of daily life without short- to mid-term recurrences, but postoperatively the MPT group had higher incidence of chronic non-disabling groin pain. Although the MPT is less invasive, the additional protective patch in the preperitoneal space of the PHS may provide a further safeguard against recurrences, especially for those patients with attenuated inguinal floor. Long-term follow-up is needed.

Randomized controlled trial comparing prolene hernia system and lichtenstein method for inguinal hernia repair.

PubMed

Sanjay, Pandanaboyana; Harris, Dean; Jones, Philippa; Woodward, Alan

2006-07-01

There are no data regarding the long-term outcomes of prolene hernia system (PHS) mesh in the published reports. The aim of the study was to compare the short-term and long-term outcomes of the PHS mesh with the Lichtenstein mesh technique. Sixty-four patients with inguinal hernia were randomized to undergo either a PHS or a Lichtenstein repair under local anaesthesia as a day case. Early outcome measures were duration of surgery, pain scores, analgesic requirements, time to return to work, driving and full activity. Long-term outcome measures were chronic groin pain and recurrence. Mean duration of surgery in the PHS group was 36 min (SD +/- 11) versus 34 min in the Lichtenstein group (SD +/- 8; P = 0.3). There was no significant difference in analgesic requirements (P = 0.65). Overall mean pain score was 3.5/10 versus 2.5/10 (P = 0.1). Mean time to return to work was 42 versus 30 days (P = 0.3), returning to driving was 20 versus 14 days (P = 0.2) and full activity was 21 versus 22 days (P = 0.8). Chronic groin pain developed in four patients in the PHS group (12.9%) and in five patients in the Lichtenstein group (15.1%; P > 0.05). One patient developed recurrent herniation in the PHS group. The median follow up was 4.2 years (range, 4-4.6 years). Patient satisfaction was very high with both the techniques. There is no significant difference in the early and long-term outcomes between PHS and Lichtenstein hernia repairs. The PHS technique involving preperitoneal dissection is well tolerated and easy to carry out under local anaesthesia.

Structure of the posthepatic septum and its influence on visceral topology in the tegu lizard, Tupinambis merianae (Teiidae: Reptilia).

PubMed

Klein, Wilfried; Abe, Augusto S; Andrade, Denis V; Perry, Steven F

2003-11-01

The posthepatic septum (PHS) divides the body cavity of Tupinambis merianae into two parts: the cranial one containing the lungs and liver and the caudal one containing the remaining viscera. The PHS is composed of layers of collagenous fibers and bundles of smooth muscle, neither of which show systematic orientation, as well as isolated blood vessels, lymphatic vessels, and nerves. Striated muscle of the abdominal wall does not invade the PHS. The contractions of the smooth muscles may stabilize the pleurohepatic cavity under conditions of elevated aerobic needs rather than supporting breathing on a breath-by-breath basis. Surgical removal of the PHS changes the anatomical arrangement of the viscera significantly, with stomach and intestine invading the former pleurohepatic cavity and reducing the space for the lungs. Thus, the PHS is essential to maintain the visceral topography in Tupinambis. Copyright 2003 Wiley-Liss, Inc.

Static lung compliance and body pressures in Tupinambis merianae with and without post-hepatic septum.

PubMed

Klein, Wilfried; Abe, Augusto S; Perry, Steven F

2003-04-15

The surgical removal of the post-hepatic septum (PHS) in the tegu lizard, Tupinambis merianae, significantly reduces resting lung volume (V(Lr)) and maximal lung volume (V(Lm)) when compared with tegus with intact PHS. Standardised for body mass (M(B)), static lung compliance was significantly less in tegus without PHS. Pleural and abdominal pressures followed, like ventilation, a biphasic pattern. In general, pressures increased during expiration and decreased during inspiration. However, during expiration pressure changes showed a marked intra- and interindividual variation. The removal of the PHS resulted in a lower cranio-caudal intracoelomic pressure differential, but had no effect on the general pattern of pressure changes accompanying ventilation. These results show that a perforated PHS that lacks striated muscle has significant influence on static breathing mechanics in Tupinambis and by analogy provides valuable insight into similar processes that led to the evolution of the mammalian diaphragm.

Ground Zero recollections of US Public Health Service nurses deployed to New York City in September 2001.

PubMed

Knebel, Ann R; Martinelli, Angela M; Orsega, Susan; Doss, Thomas L; Balingit-Wines, Ana Marie; Konchan, Carol L

2010-06-01

The events of September 11, 2001, set in motion the broadest emergency response ever conducted by the US Department of Health and Human Services. In this article, some of the nurses who deployed to New York City in the aftermath of that horrific attack on the United States offer their recollections of the events. Although Public Health Service Commissioned Corps (PHS CC) officers participated in deployments before 9/11, this particular deployment accelerated the transformation of the PHS CC, because people came to realize the tremendous potential of a uniformed service of 6,000 health care professionals. When not responding to emergencies, PHS CC nurses daily serve the mission of the PHS to protect, promote, and advance the health and safety of the nation. In times of crisis, the PHS CC nurses stand ready to deploy in support of those in need of medical assistance. Published by Elsevier Inc.

42 CFR 9.12 - Compliance with the Standards of Care, and USDA and PHS policies and regulations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Compliance with the Standards of Care, and USDA and PHS policies and regulations. 9.12 Section 9.12 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF... SUPPORTED SANCTUARY SYSTEM § 9.12 Compliance with the Standards of Care, and USDA and PHS policies and...

42 CFR 9.12 - Compliance with the Standards of Care, and USDA and PHS policies and regulations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Compliance with the Standards of Care, and USDA and PHS policies and regulations. 9.12 Section 9.12 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF... SUPPORTED SANCTUARY SYSTEM § 9.12 Compliance with the Standards of Care, and USDA and PHS policies and...

42 CFR 9.12 - Compliance with the Standards of Care, and USDA and PHS policies and regulations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Compliance with the Standards of Care, and USDA and PHS policies and regulations. 9.12 Section 9.12 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF... SUPPORTED SANCTUARY SYSTEM § 9.12 Compliance with the Standards of Care, and USDA and PHS policies and...

42 CFR 9.12 - Compliance with the Standards of Care, and USDA and PHS policies and regulations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Compliance with the Standards of Care, and USDA and PHS policies and regulations. 9.12 Section 9.12 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF... SUPPORTED SANCTUARY SYSTEM § 9.12 Compliance with the Standards of Care, and USDA and PHS policies and...

42 CFR 9.12 - Compliance with the Standards of Care, and USDA and PHS policies and regulations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Compliance with the Standards of Care, and USDA and PHS policies and regulations. 9.12 Section 9.12 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF... SUPPORTED SANCTUARY SYSTEM § 9.12 Compliance with the Standards of Care, and USDA and PHS policies and...

Informal Trade of Psychoactive Herbal Products in the City of Diadema, SP, Brazil: Quality and Potential Risks

PubMed Central

Soares Neto, Julino Assunção Rodrigues; Kato, Edna Myiake; Galduróz, José Carlos F.; Marques, Luis Carlos; Macrini, Thiago; Rodrigues, Eliana

2013-01-01

The present study aimed to assess the quality and risks involved in the consumption of psychoactive herbal products (PHs) that are available through informal commerce in the city of Diadema, SP, Brazil. Methods of ethnography were used to conduct the fieldwork during which four dealers were selected to record the collection, handling, packaging, types of PHs marketed, and their therapeutic purposes. In addition, lots of the PHs selected were purchased from the dealers and analyzed using microbiology and pharmacognosy techniques. 217 PHs were recorded and categorized into two main groups: stimulants (67%) and depressants (27%) of the central nervous system; sixteen of them were selected, and their 52 lots were acquired. The deficiencies observed in handling and packaging these lots by dealers were confirmed by microbiological analysis; 80.8% of them presented risk according to the indicators defined by the Brazilian Pharmacopoeia. The pharmacognostic analysis confirmed the authenticity of only 9 to 16 PHs analyzed. In addition, descriptions of contraindications, adverse reactions, and drug interactions were found in the literature for the PHs. The results of this study allow the observation of the priorities for the sanitary adequacy of the popular trade of herbs. PMID:23818934

Clinical Manifestations, Outcomes, and Etiologies of Perinatal Stroke in Taiwan: Comparisons between Ischemic, and Hemorrhagic Stroke Based on 10-year Experience in A Single Institute.

PubMed

Lee, Chien-Chung; Lin, Jainn-Jim; Lin, Kuang-Lin; Lim, Wai-Ho; Hsu, Kai-Hsiang; Hsu, Jen-Fu; Fu, Ren-Huei; Chiang, Ming-Chou; Chu, Shih-Ming; Lien, Reyin

2017-06-01

Perinatal stroke is a common cause of established neurological sequelae. Although several risk factors have been identified, many questions regarding causes and clinical outcomes remain unanswered. This study investigated the clinical manifestations and outcomes of perinatal stroke and identified its etiologies in Taiwan. We searched the reports of head magnetic resonance imaging and computed tomography performed between January 2003 and December 2012. The medical records of enrolled infants with perinatal stroke were also reviewed. Thirty infants with perinatal stroke were identified; 10 infants had perinatal arterial ischemic stroke (PAIS) and 20 had perinatal hemorrhagic stroke (PHS). Neonatal seizure was the most common manifestation and presented in 40% of infants with PAIS and 50% of infants with PHS. All survivors with PAIS and 77% of the surviving infants with PHS developed neurological sequelae. Acute seizure manifestation was associated with poststroke epilepsy in infants with PHS but not in infants with PAIS (86% vs. 0%, p=0.005). PAIS was mostly caused by dysfunctional hemostasis (20%) and embolism (20%), whereas PHS was mostly attributable to birth asphyxia (30%). Perinatal stroke is associated with high mortality and morbidity rates in infants. Clinically, it can be difficult to distinguish PAIS and PHS. One should keep a high level of suspicion, especially for PHS, if infants develop unexplained seizure, cyanosis, conscious change, anemia, and/or thrombocytopenia. A systematic diagnostic approach is helpful in identifying the etiologies of perinatal stroke. Copyright © 2016. Published by Elsevier B.V.

Metal-Containing Polystyrene Beads as Standards for Mass Cytometry

PubMed Central

Abdelrahman, Ahmed I.; Ornatsky, Olga; Bandura, Dmitry; Kinach, Robert; Dai, Sheng; Thickett, Stuart C.; Tanner, Scott

2010-01-01

We examine the suitability of metal-containing polystyrene beads for the calibration of a mass cytometer instrument, a single particle analyser based on an inductively coupled plasma ion source and a time of flight mass spectrometer. These metal-containing beads are also verified for their use as internal standards for this instrument. These beads were synthesized by multiple-stage dispersion polymerization with acrylic acid as a comonomer. Acrylic acid acts as a ligand to anchor the metal ions within the interior of the beads. Mass cytometry enabled the bead-by-bead measurement of the metal-content and determination of the metal-content distribution. Beads synthesized by dispersion polymerization that involved three stages were shown to have narrower bead-to-bead variation in their lanthanide content than beads synthesized by 2-stage dispersion polymerization. The beads exhibited insignificant release of their lanthanide content to aqueous solutions of different pHs over a period of six months. When mixed with KG1a or U937 cell lines, metal-containing polymer beads were shown not to affect the mass cytometry response to the metal content of element-tagged antibodies specifically attached to these cells. PMID:20390041

Metal-Containing Polystyrene Beads as Standards for Mass Cytometry.

PubMed

Abdelrahman, Ahmed I; Ornatsky, Olga; Bandura, Dmitry; Baranov, Vladimir; Kinach, Robert; Dai, Sheng; Thickett, Stuart C; Tanner, Scott; Winnik, Mitchell A

2010-01-01

We examine the suitability of metal-containing polystyrene beads for the calibration of a mass cytometer instrument, a single particle analyser based on an inductively coupled plasma ion source and a time of flight mass spectrometer. These metal-containing beads are also verified for their use as internal standards for this instrument. These beads were synthesized by multiple-stage dispersion polymerization with acrylic acid as a comonomer. Acrylic acid acts as a ligand to anchor the metal ions within the interior of the beads. Mass cytometry enabled the bead-by-bead measurement of the metal-content and determination of the metal-content distribution. Beads synthesized by dispersion polymerization that involved three stages were shown to have narrower bead-to-bead variation in their lanthanide content than beads synthesized by 2-stage dispersion polymerization. The beads exhibited insignificant release of their lanthanide content to aqueous solutions of different pHs over a period of six months. When mixed with KG1a or U937 cell lines, metal-containing polymer beads were shown not to affect the mass cytometry response to the metal content of element-tagged antibodies specifically attached to these cells.

Aseismic deep subduction of the Philippine Sea plate and slab window

NASA Astrophysics Data System (ADS)

Huang, Zhouchuan; Zhao, Dapeng; Hasegawa, Akira; Umino, Norihito; Park, Jung-Ho; Kang, Ik-Bum

2013-10-01

We have made great efforts to collect and combine a large number of high-quality data from local earthquakes and teleseismic events recorded by the dense seismic networks in both South Korea and West Japan. This is the first time that a large number of Korean and Japanese seismic data sets are analyzed jointly. As a result, a high-resolution 3-D P-wave velocity model down to 700-km depth is determined, which clearly shows that the Philippine Sea (PHS) plate has subducted aseismically down to ˜460 km depth under the Japan Sea, Tsushima Strait and East China Sea. The aseismic PHS slab is visible in two areas: one is under the Japan Sea off western Honshu, and the other is under East China Sea off western Kyushu. However, the aseismic PHS slab is not visible between the two areas, where a slab window has formed. The slab window is located beneath the center of the present study region where many teleseismic rays crisscross. Detailed synthetic tests were conducted, which indicate that both the aseismic PHS slab and the slab window are robust features. Using the teleseismic data recorded by the Japanese stations alone, the aseismic PHS slab and the slab window were also revealed (Zhao et al., 2012), though the ray paths in the Japanese data set crisscross less well offshore. The slab window may be caused by the subducted Kyushu-Palau Ridge and Kinan Seamount Chain where the PHS slab may be segmented. Hot mantle upwelling is revealed in the big mantle wedge above the Pacific slab under the present study region, which may have facilitated the formation of the PHS slab window. These novel findings may shed new light on the subduction history of the PHS plate and the dynamic evolution of the Japan subduction zone.

Polygenic hazard scores in preclinical Alzheimer disease.

PubMed

Tan, Chin Hong; Hyman, Bradley T; Tan, Jacinth J X; Hess, Christopher P; Dillon, William P; Schellenberg, Gerard D; Besser, Lilah M; Kukull, Walter A; Kauppi, Karolina; McEvoy, Linda K; Andreassen, Ole A; Dale, Anders M; Fan, Chun Chieh; Desikan, Rahul S

2017-09-01

Identifying asymptomatic older individuals at elevated risk for developing Alzheimer disease (AD) is of clinical importance. Among 1,081 asymptomatic older adults, a recently validated polygenic hazard score (PHS) significantly predicted time to AD dementia and steeper longitudinal cognitive decline, even after controlling for APOE ɛ4 carrier status. Older individuals in the highest PHS percentiles showed the highest AD incidence rates. PHS predicted longitudinal clinical decline among older individuals with moderate to high Consortium to Establish a Registry for Alzheimer's Disease (amyloid) and Braak (tau) scores at autopsy, even among APOE ɛ4 noncarriers. Beyond APOE, PHS may help identify asymptomatic individuals at highest risk for developing Alzheimer neurodegeneration. Ann Neurol 2017;82:484-488. © 2017 American Neurological Association.

Expectations, anxiety, depression, and physical health status as predictors of recovery in open-heart surgery patients.

PubMed

Chunta, Kristy S

2009-01-01

Recovery after open-heart surgery is a complex process that presents psychosocial and physical challenges that continue well after discharge. The purpose of this study was to examine the relationship among expectations, anxiety, depression, and physical health status (PHS) and to determine predictors of postoperative PHS in open-heart surgery patients. A convenience sample (N = 54) was recruited from 2 hospitals in rural regions from 2 different mid-Atlantic states. The sample included participants who underwent coronary artery bypass graft or valve replacement surgery for the first time. The study used a longitudinal design, and data were collected preoperatively in the hospital or surgeons' offices and 4 weeks postoperatively by telephone interviews. Participants were interviewed using the following questionnaires: the Future Expectations Regarding Life with Heart Disease scale, the Hospital Anxiety and Depression scale, and the Medical Outcomes Study 36-Item Short Form Health Survey. Repeated-measures analysis of variance, Pearson product-moment correlations, and multiple regression were used for data analyses. Statistical analysis revealed that anxiety (P = .002) and depression (P = .026) scores decreased postoperatively. Significant relationships were found among the preoperative and postoperative variables: expectations, anxiety, depression, and PHS. Analyses also found that preoperative expectations, anxiety, depression, and PHS contributed 38% of the variance of postoperative PHS (P < .001). However, the postoperative variables were not significant predictors of postoperative PHS (P = .075). The findings support the need for interventions to assist patients in developing realistic expectations and for clinicians to screen patients for anxiety and depression before and after surgery. Future research needs to measure PHS at various times postoperatively to identify continued limitations after surgery.

48 CFR 370.401 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... is HHS policy that contracting activities shall not award a contract involving live vertebrate.../PHS-supported or HHS/PHS-conducted activities involving the care and use of live vertebrate animals...

The Work of US Public Health Service Officers in Puerto Rico, 1898-1919.

PubMed

Rigau-Pérez, Jose G

2017-09-01

The history of the US Public Health Service (PHS) is usually presented in terms of diseases or discoveries; this article examines twenty years' activity in one location. When the United States invaded Puerto Rico in 1898, the Marine Hospital Service (now PHS) took responsibility for foreign quarantine, inspection of immigrants, and medical care for merchant seamen. Its officers evaluated the sanitary conditions of port cities, helped reorganize local disease surveillance and control, and investigated endemic diseases (e.g., hookworm-related anemia) and epidemics (e.g., bubonic plague). After World War I and pandemic influenza, and the greater self-government allowed Puerto Rico by Congress in 1917, PHS officers withdrew from routine local sanitary actions. A narrow geographic focus (Puerto Rico), to examine PHS activity over time (1898 to 1919) provides a richer picture of the agency's impact, and reveals how the sum of disease control activities affected the development of an area's health status and institutions. The duties and, importantly, the personal initiatives of PHS officers in Puerto Rico, such as WW King, produced lasting impact on scientific institutions and administrative, professional, and health care practices.

Distribution of tetracycline resistance genes in anaerobic treatment of waste sludge: The role of pH in regulating tetracycline resistant bacteria and horizontal gene transfer.

PubMed

Huang, Haining; Chen, Yinguang; Zheng, Xiong; Su, Yinglong; Wan, Rui; Yang, Shouye

2016-10-01

Although pH value has been widely regarded as an important factor that affects resource recovery of waste sludge, the potential influence of diverse pHs on the distribution of tetracycline resistance genes (TRGs) during sludge anaerobic treatment is largely unknown. Here we reported that in the range of pH 4-10, 0.58-1.18 log unit increase of target TRGs was observed at pH 4, compared with that at pH 7, while 0.70-1.31 log unit further removal were obtained at pH 10. Mechanism study revealed that varied pHs not only altered the community structures of tetracycline resistant bacteria (TRB), but also changed their relative abundances, benefitting the propagation (acidic pHs) or attenuation (alkaline pHs) of TRB. Further investigation indicated that the amount and gene-possessing abilities of key genetic vectors for horizontal TRGs transfer were greatly promoted at acidic pHs but restricted under alkaline conditions. Copyright © 2016 Elsevier Ltd. All rights reserved.

Pre-harvest sprouting resistance and haplotype variation of ThVp-1 gene in the collection of wheat-wheatgrass hybrids

PubMed Central

Kocheshkova, A. A.; Kroupin, P. Yu.; Bazhenov, M. S.; Karlov, G. I.; Pochtovyy, A. A.; Upelniek, V. P.; Belov, V. I.

2017-01-01

The germplasm collection of 87 wheat-wheatgrass hybrids developed in Tsitisin Main Botanical Garden (Russia, Moscow) was evaluated for resistance to pre-harvest sprouting (PHS) by spike sprouting (SS) and germination index (GI) assays as well as for spike and grain features. The PHS resistance variation and haplotype polymorphism of the wheatgrass ThVp-1 and wheat TaVp-1B genes orthologues of Vp-1 was revealed in the studied collection. Four haplotypes of ThVp-1 were revealed: ThVp-1a (41% of the entries), ThVp-1b (13%), ThVp-1c (29%), and ThVp-1d (15%). The association between the allelic state of ThVp-1 and PHS resistance in the wheat-wheatgrass hybrids was shown: haplotype ThVp-1d of the wheatgrass Vp-1 gene is significantly associated with reduced PHS in the wheat-wheatgrass hybrids (mean SS 0.33, mean GI 0.64). The resistant entries may be perspective as a source of PHS resistance in the development of commercial cultivars of perennial wheat. PMID:29131854

Disruptive Innovation Can Prevent the Next Pandemic.

PubMed

Shaikh, Affan T; Ferland, Lisa; Hood-Cree, Robert; Shaffer, Loren; McNabb, Scott J N

2015-01-01

Public health surveillance (PHS) is at a tipping point, where the application of novel processes, technologies, and tools promise to vastly improve efficiency and effectiveness. Yet twentieth century, entrenched ideology and lack of training results in slow uptake and resistance to change. The term disruptive innovation - used to describe advances in technology and processes that change existing markets - is useful to describe the transformation of PHS. Past disruptive innovations used in PHS, such as distance learning, the smart phone, and field-based laboratory testing have outpaced older services, practices, and technologies used in the traditional classroom, governmental offices, and personal communication, respectively. Arguably, the greatest of these is the Internet - an infrastructural innovation that continues to enable exponential benefits in seemingly limitless ways. Considering the Global Health Security Agenda and facing emerging and reemerging infectious disease threats, evolving environmental and behavioral risks, and ever changing epidemiologic trends, PHS must transform. Embracing disruptive innovation in the structures and processes of PHS can be unpredictable. However, it is necessary to strengthen and unlock the potential to prevent, detect, and respond.

TH-CD-207B-06: Swank Factor of Segmented Scintillators in Multi-Slice CT Detectors: Pulse Height Spectra and Light Escape

DOE Office of Scientific and Technical Information (OSTI.GOV)

Howansky, A; Peng, B; Lubinsky, A

Purpose: Pulse height spectra (PHS) have been used to determine the Swank factor of a scintillator by measuring fluctuations in its light output per x-ray interaction. The Swank factor and x-ray quantum efficiency of a scintillator define the upper limit to its imaging performance, i.e. DQE(0). The Swank factor below the K-edge is dominated by optical properties, i.e. variations in light escape efficiency from different depths of interaction, denoted e(z). These variations can be optimized to improve tradeoffs in x-ray absorption, light yield, and spatial resolution. This work develops a quantitative model for interpreting measured PHS, and estimating e(z) onmore » an absolute scale. The method is used to investigate segmented ceramic GOS scintillators used in multi-slice CT detectors. Methods: PHS of a ceramic GOS plate (1 mm thickness) and segmented GOS array (1.4 mm thick) were measured at 46 keV. Signal and noise propagation through x-ray conversion gain, light escape, detection by a photomultiplier tube and dynode amplification were modeled using a cascade of stochastic gain stages. PHS were calculated with these expressions and compared to measurements. Light escape parameters were varied until modeled PHS agreed with measurements. The resulting estimates of e(z) were used to calculate PHS without measurement noise to determine the inherent Swank factor. Results: The variation in e(z) was 67.2–89.7% in the plate and 40.2–70.8% in the segmented sample, corresponding to conversion gains of 28.6–38.1 keV{sup −1} and 17.1–30.1 keV{sup −1}, respectively. The inherent Swank factors of the plate and segmented sample were 0.99 and 0.95, respectively. Conclusion: The high light escape efficiency in the ceramic GOS samples yields high Swank factors and DQE(0) in CT applications. The PHS model allows the intrinsic optical properties of scintillators to be deduced from PHS measurements, thus it provides new insights for evaluating the imaging performance of segmented ceramic GOS scintillators.« less

Different host complement systems and their interactions with saliva from Lutzomyia longipalpis (Diptera, Psychodidae) and Leishmania infantum promastigotes.

PubMed

Mendes-Sousa, Antonio Ferreira; Nascimento, Alexandre Alves Sousa; Queiroz, Daniel Costa; Vale, Vladimir Fazito; Fujiwara, Ricardo Toshio; Araújo, Ricardo Nascimento; Pereira, Marcos Horácio; Gontijo, Nelder Figueiredo

2013-01-01

Lutzomyia longipalpis is the vector of Leishmania infantum in the New World, and its saliva inhibits classical and alternative human complement system pathways. This inhibition is important in protecting the insect´s midgut from damage by the complement. L. longipalpis is a promiscuous blood feeder and must be protected against its host's complement. The objective of this study was to investigate the action of salivary complement inhibitors on the sera of different host species, such as dogs, guinea pigs, rats and chickens, at a pH of 7.4 (normal blood pH) and 8.15 (the midgut pH immediately after a blood meal). We also investigated the role of the chicken complement system in Leishmania clearance in the presence and absence of vector saliva. The saliva was capable of inhibiting classical pathways in dogs, guinea pigs and rats at both pHs. The alternative pathway was not inhibited except in dogs at a pH of 8.15. The chicken classical pathway was inhibited only by high concentrations of saliva and it was better inhibited by the midgut contents of sand flies. Neither the saliva nor the midgut contents had any effect on the avian alternative pathway. Fowl sera killed L. infantum promastigotes, even at a low concentration (2%), and the addition of L. longipalpis saliva did not protect the parasites. The high body temperature of chickens (40°C) had no effect on Leishmania viability during our assays. Salivary inhibitors act in a species-specific manner. It is important to determine their effects in the natural hosts of Leishmania infantum because they act on canid and rodent complements but not on chickens (which do not harbour the parasite). Moreover, we concluded that the avian complement system is the probable mechanism through which chickens eliminate Leishmania and that their high body temperature does not influence this parasite.

Water oxidation catalysis with nonheme iron complexes under acidic and basic conditions: homogeneous or heterogeneous?

PubMed

Hong, Dachao; Mandal, Sukanta; Yamada, Yusuke; Lee, Yong-Min; Nam, Wonwoo; Llobet, Antoni; Fukuzumi, Shunichi

2013-08-19

Thermal water oxidation by cerium(IV) ammonium nitrate (CAN) was catalyzed by nonheme iron complexes, such as Fe(BQEN)(OTf)2 (1) and Fe(BQCN)(OTf)2 (2) (BQEN = N,N'-dimethyl-N,N'-bis(8-quinolyl)ethane-1,2-diamine, BQCN = N,N'-dimethyl-N,N'-bis(8-quinolyl)cyclohexanediamine, OTf = CF3SO3(-)) in a nonbuffered aqueous solution; turnover numbers of 80 ± 10 and 20 ± 5 were obtained in the O2 evolution reaction by 1 and 2, respectively. The ligand dissociation of the iron complexes was observed under acidic conditions, and the dissociated ligands were oxidized by CAN to yield CO2. We also observed that 1 was converted to an iron(IV)-oxo complex during the water oxidation in competition with the ligand oxidation. In addition, oxygen exchange between the iron(IV)-oxo complex and H2(18)O was found to occur at a much faster rate than the oxygen evolution. These results indicate that the iron complexes act as the true homogeneous catalyst for water oxidation by CAN at low pHs. In contrast, light-driven water oxidation using [Ru(bpy)3](2+) (bpy = 2,2'-bipyridine) as a photosensitizer and S2O8(2-) as a sacrificial electron acceptor was catalyzed by iron hydroxide nanoparticles derived from the iron complexes under basic conditions as the result of the ligand dissociation. In a buffer solution (initial pH 9.0) formation of the iron hydroxide nanoparticles with a size of around 100 nm at the end of the reaction was monitored by dynamic light scattering (DLS) in situ and characterized by X-ray photoelectron spectra (XPS) and transmission electron microscope (TEM) measurements. We thus conclude that the water oxidation by CAN was catalyzed by short-lived homogeneous iron complexes under acidic conditions, whereas iron hydroxide nanoparticles derived from iron complexes act as a heterogeneous catalyst in the light-driven water oxidation reaction under basic conditions.

[A rare cause of oral pain: The pterygoid hamulus syndrome].

PubMed

Bandini, M; Corre, P; Huet, P; Khonsari, R H

2015-12-01

Pterygoid hamulus syndrome (PHS) is a rare cause of orofacial and oropharyngeal pain. PHS can be associated with a hamulus hypertrophy or with a bursitis of the palatosalpingeus but it has not always an anatomic cause. A 36-year-old woman was seen for a constant posterior palatal pain spreading towards oropharynx, increasing during swallowing and lasting for more than 6 months. Physical examination showed an erythema of the soft palate, medially to the hamulus. Hamulus palpation was painful and revealed hamulus hypertrophia on both sides. A bilateral PHS was evocated. This observation is typical of a PHS. We propose a review of the literature of this little-known syndrome. Treatment is initially conservative (corticosteroids) but surgery can be proposed in case of morphological anomalies of the hamulus. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

42 CFR 93.407 - HHS administrative actions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON... cooperative agreement. (6) Special review of all requests for PHS funding. (7) Imposition of supervision... PHS funding component, and the debarring official. ...

The pedagogical value of a student-run community-based experiential learning project: The Yong Loo Lin School of Medicine Public Health Screening.

PubMed

Wee, Liang En; Yeo, Wei Xin; Tay, Clifton M; Lee, Jeannette J M; Koh, Gerald C H

2010-09-01

We assessed the pedagogical value of a student-led community-based experiential learning project called the Public Health Screening (PHS) run by medical and nursing students of the National University of Singapore's Yong Loo Lin School of Medicine (NUS YLLSoM). We conducted a cross-sectional study using a self-administered anonymised questionnaire on medical and nursing students who participated in PHS using the Fund for the Improvement of Postsecondary Education (FIPSE) Survey Instrument. Participants also gave an overall score for their learning experience at the PHS. The participation rate was 93.1% (576/619) for medical students and 100% (37/37) for nursing students. All participants gave the PHS learning experience a high rating (median = 8 out of maximum of 10, inter-quartile range, 7 to 9). A majority of participants felt that PHS had helped them to improve across all domains surveyed. For medical students, those in preclinical years and females were independently more likely to feel that PHS had helped them to improve in communication skills, teamwork, ability to identify social issues, taking action, and gaining and applying their knowledge than those in clinical years and males. Improved ability to interact with patients (β=1.64, 95%CI, 1.01-2.27), appreciation of challenges to healthcare faced by Singaporeans from lower income groups (β=0.93, 95%CI, 0.49-1.37), thinking of others (β=0.70, 95%CI, 0.04-1.37) and tolerance of different people (β =0.63, 95%CI, 0.17-1.10) were strongly associated with the overall rating score. PHS was a positive learning experience in a wide range of domains for all students involved. This suggests that student-organised community-based experiential learning projects have potential educational value for both medical and nursing students.

Unraveling Key Metabolomic Alterations in Wheat Embryos Derived from Freshly Harvested and Water-Imbibed Seeds of Two Wheat Cultivars with Contrasting Dormancy Status

PubMed Central

Das, Aayudh; Kim, Dea-Wook; Khadka, Pramod; Rakwal, Randeep; Rohila, Jai S.

2017-01-01

Untimely rains in wheat fields during harvest season can cause pre-harvest sprouting (PHS), which deteriorates the yield and quality of wheat crop. Metabolic homeostasis of the embryo plays a role in seed dormancy, determining the status of the maturing grains either as dormant (PHS-tolerant) or non-dormant (PHS-susceptible). Very little is known for direct measurements of global metabolites in embryonic tissues of dormant and non-dormant wheat seeds. In this study, physiologically matured and freshly harvested wheat seeds of PHS-tolerant (cv. Sukang, dormant) and PHS-susceptible (cv. Baegjoong, non-dormant) cultivars were water-imbibed, and the isolated embryos were subjected to high-throughput, global non-targeted metabolomic profiling. A careful comparison of identified metabolites between Sukang and Baegjoong embryos at 0 and 48 h after imbibition revealed that several key metabolic pathways [such as: lipids, fatty acids, oxalate, hormones, the raffinose family of oligosaccharides (RFOs), and amino acids] and phytochemicals were differentially regulated between dormant and non-dormant varieties. Most of the membrane lipids were highly reduced in Baegjoong compared to Sukang, which indicates that the cell membrane instability in response to imbibition could also be a key factor in non-dormant wheat varieties for their untimely germination. This study revealed that several key marker metabolites (e.g., RFOs: glucose, fructose, maltose, and verbascose), were highly expressed in Baegjoong after imbibition. Furthermore, the data showed that the key secondary metabolites and phytochemicals (vitexin, chrysoeriol, ferulate, salidroside and gentisic acid), with known antioxidant properties, were comparatively low at basal levels in PHS-susceptible, non-dormant cultivar, Baegjoong. In conclusion, the results of this investigation revealed that after imbibition the metabolic homeostasis of dormant wheat is significantly less affected compared to non-dormant wheat. The inferences from this study combined with proteomic and transcriptomic studies will advance the molecular understanding of the pathways and enzyme regulations during PHS. PMID:28747920

Tuskegee redux: evolution of legal mandates for human experimentation.

PubMed

Levine, Robert S; Williams, Jamila C; Kilbourne, Barbara A; Juarez, Paul D

2012-11-01

Human health experiments systematically expose people to conditions beyond the boundaries of medical evidence. Such experiments have included legal-medical collaboration, exemplified in the U.S. by the Public Health Service (PHS) Syphilis Study (Tuskegee). That medical experiment was legal, conforming to segregationist protocols and specific legislative authorization which excluded a selected group of African Americans from any medical protection from syphilis. Subsequent corrective action outlawed unethical medical experiments but did not address other forms of collaboration, including PHS submission to laws which may have placed African American women at increased risk from AIDS and breast cancer. Today, anti-lobbying law makes it a felony for PHS workers to openly challenge legally anointed suspension of medical evidence. African Americans and other vulnerable populations may thereby face excess risks-not only from cancer, but also from motor vehicle crashes, firearm assault, end stage renal disease, and other problems-with PHS workers as silent partners.

Tuskegee redux: Evolution of legal mandates for human experimentation

PubMed Central

Levine, Robert S.; Williams, Jamila C.; Kilbourne, Barbara A.; Juarez, Paul D.

2013-01-01

Human health experiments systematically expose people to conditions beyond the boundaries of medical evidence. Such experiments have included legal-medical collaboration, exemplified in the US by the PHS Syphilis Study (Tuskegee). That medical experiment was legal, conforming to segregationist protocols and specific legislative authorization which excluded a selected group of African Americans from any medical protection from syphilis. Subsequent corrective action outlawed unethical medical experiments but did not address other forms of collaboration, including PHS submission to laws which may have placed African American women at increased risk from AIDS and breast cancer. Today, anti-lobbying law makes it a felony for PHS workers to openly question legally anointed suspension of medical evidence. African Americans and other vulnerable populations may thereby face excess risks -- not only from cancer, but also from motor vehicle crashes, firearm assault, end stage renal disease and other problems -- with PHS workers as silent partners. PMID:23124504

Probing the coupling between proton and electron transfer in Photosystem II core complexes containing a 3-fluorotyrosine

PubMed Central

Rappaport, Fabrice; Boussac, Alain; Force, Dee Ann; Peloquin, Jeffrey; Brynda, Marcin; Sugiura, Miwa; Un, Sun; Britt, R. David; Diner, Bruce A.

2009-01-01

The catalytic cycle of numerous enzymes involves the coupling between proton transfer and electron transfer. Yet, the understanding of this coordinated transfer in biological systems remains limited, likely because its characterization relies on the controlled but experimentally challenging modifications of the free energy changes associated with either the electron or proton transfer. We have performed such a study here in Photosystem II. The driving force for electron transfer from TyrZ to P680•+ has been decreased by ~ 80 meV by mutating the axial ligand of P680, and that for proton transfer upon oxidation of TyrZ by substituting a 3-fluorotyrosine (3F-TyrZ) for TyrZ. In Mn-depleted Photosystem II, the dependence upon pH of the oxidation rates of TyrZ and 3F-TyrZ were found to be similar. However, in the pH range where the phenolic hydroxyl of TyrZ is involved in a H-bond with a proton acceptor, the activation energy of the oxidation of 3F-TyrZ is decreased by 110 meV, a value which correlates with the in vitro finding of a 90 meV stabilization energy to the phenolate form of 3F-Tyr when compared to Tyr (Seyedsayamdost et al., 2006, JACS 128:1569–79). Thus, when the phenol of YZ acts as a H-bond-donor, its oxidation by P680•+ is controlled by its prior deprotonation. This contrasts with the situation prevailing at lower pH, where the proton acceptor is protonated and therefore unavailable, in which the oxidation-induced proton transfer from the phenolic hydroxyl of TyrZ has been proposed to occur concertedly with the electron transfer to P680•+. This suggests a switch between a concerted proton/electron transfer at pHs < 7.5 to a sequential one at pHs > 7.5 and illustrates the roles of the H-bond and of the likely salt-bridge existing between the phenolate and the nearby proton acceptor in determining the coupling between proton and electron transfer. PMID:19265377

Development of Mathematic Model of Cold Welding at Drawing-up the Flange Joint of Pneumohydraulic Systems

NASA Astrophysics Data System (ADS)

Boyko, Y. S.

2002-01-01

Provision of high airtightness of joints of pipe- lines of pneumohydraulic systems (PHS) operating under high pressure, is an important task for designing and operation of launch vehicles. In the process of assembly and tests of PHS of launch vehicles, it was found that detachable flange joints do not lose their airtightness after removal of fastening elements, even in conditions of standard loads. The task of this work is in studying a phenomenon connected with initiation of the observed effect of adhesion and also stresses in the zone of contact at drawing- up the flange detachable joints with a plastic gasket. Investigations have shown that density of the joint is kept due to cold welding, as the created conditions are helpful for that process. As a result of the investigations performed, we have developed a mathematic model which is based on application of the theory of metal bonds; that theory explains the essence of the effect observed. Basic factors which provide optimum mode of cold welding, are effort which can cause microplastic deformation and form maximum contact, and also quality of processing the material of the surfaces joined. Strength of all- metal joint depends on factual area of contact. So, surface processing quality defines a configuration of microbulges which come into contact not simultaneously, and their stressed state is different, and it influences the character of dependence of the contact area on loading. Results of calculations by the mathematic model are expressed by dependencies of factual area of contact and a single diameter of the contact spot on the load applied which compresses the materials with various physical properties, and on the surface processing quality. The mathematic model allows to explain the common character of the cold welding process in detachable flange joints with the plastic gasket, to determine the nature and the character of acting forces, to define kinetics and the mechanism of formation of cold welding of detachable joints. It also helps to analyze the state of airtightness and to metal welding technology in the plastic state at drawing- up of detachable flange joints with a plastic gasket and to review cold welding as a positive phenomenon.

Impact of preoperative hormonal stimulation on postoperative complication rates after hypospadias repair: a meta-analysis.

PubMed

Chao, Min; Zhang, Yin; Liang, Chaozhao

2017-06-01

To improve the surgical outcome of hypospadias repair surgery, preoperative hormonal stimulation (PHS) has been proposed. We conducted a meta-analysis to evaluate the impact of preoperative hormonal stimulation (PHS) treatment on complication rates following hypospadias repair surgery. A comprehensive literature search up to June 1st, 2015 was carried out for relevant studies. After literature identification and data extraction, relative ratio (RR) was calculated to compare postoperative complication rates. Heterogeneity among individual studies was tested using the Cochran χ2 Q test and quantified by calculating the I2 index. Meta-regression was applied to find potential affective factors. Overall, 428 patients from 6 studies had undergone primary hypospadias repair, of which 171 (39.95%) received some form of PHS with human chorionic gonadotropin (HCG), dihydrotestosterone (DHT) or testosterone (T). They underwent three different types of surgical techniques, including onlay island flap (N.=277), tubularized incised plate (N.=99) and Koyanagi urethroplasty (N.=52). These 6 studies classified the complication rates based on PHS. The relative ratio (RR) for a complication occurring following PHS use was 1.18 (95% CI: 0.70-2.00, Z=0.91, P=0.539). Significant heterogeneity (I2=47.1%, P=0.092) among various research literature was found and meta-regression was undertaken for the heterogeneity, but surgical technique, mean age of patients at time of surgery, types of PHS and the quality of studies were not the cause of heterogeneity. Use of T, DHT and HCG prior to hypospadias repair does not appear to increase the incidence of postoperative complications, but further investigation is needed.

Fatty acid profiles, antioxidant compounds and antiradical properties of Pinus halepensis Mill. cones and seeds.

PubMed

Dhibi, Madiha; Mechri, Beligh; Brahmi, Faten; Skhiri, Fathia; Alsaif, Mohammed A; Hammami, Mohamed

2012-06-01

Pinus halepensis (Aleppo pine) is a widespread tree that can be found in both natural and urban environments. A discrimination study based on the antioxidant compounds, antioxidant capacity and fatty acid (FA) profile of P. halepensis cones (PHC) and seeds (PHS) was performed. The total amount of phenols was about 72-fold higher in PHC extract than in PHS extract (P < 0.001). Anthocyanin and carotenoid contents were 10- and 12-fold higher respectively in PHC extract. PHC and PHS extracts at a concentration of 1 mg mL(-1) differed significantly in free radical-scavenging activity on 2,2-diphenyl-1-picrylhydrazyl radical (DPPH(•)) (86.65 vs 16.97%). PHC had higher antioxidant ability on 2,2'-azino-bis(3-ethylbenzothialozine-6-sulfonic acid) radical cation (ABTS(•+)) than PHS (EC(50) 0.368 vs 2.345 mg mL(-1)). The FA profile of PHC oil revealed its richness in saturated FAs (41.5%) and high levels of trans FA isomers, with a predominance of trans,trans-linoleic acid (4.74%). However, polyunsaturated FAs in PHS oil represented more than 64% of total FAs. PHC showed important antioxidant activities as well as high levels of bioactive compounds. Thus PHC is a potential source of natural antioxidants that may afford several health benefits. However, the lipid extract of PHS seems to have more nutritional value as a polyunsaturated oil than that of PHC, which is high in saturated and trans FAs. Copyright © 2011 Society of Chemical Industry.

Can the PHS model (ISO7933) predict reasonable thermophysiological responses while wearing protective clothing in hot environments?

PubMed

Wang, Faming; Kuklane, Kalev; Gao, Chuansi; Holmér, Ingvar

2011-02-01

In this paper, the prediction accuracy of the PHS (predicted heat strain) model on human physiological responses while wearing protective clothing ensembles was examined. Six human subjects (aged 29 ± 3 years) underwent three experimental trials in three different protective garments (clothing thermal insulation I(cl) ranges from 0.63 to 2.01 clo) in two hot environments (40 °C, relative humidities: 30% and 45%). The observed and predicted mean skin temperature, core body temperature and sweat rate were presented and statistically compared. A significant difference was found in the metabolic rate between FIRE (firefighting clothing) and HV (high visibility clothing) or MIL (military clothing) (p < 0.001). Also, the development of heart rate demonstrated the significant effects of the exposure time and clothing ensembles. In addition, the predicted evaporation rate during HV, MIL and FIRE was much lower than the experimental values. Hence, the current PHS model is not applicable for protective clothing with intrinsic thermal insulations above 1.0 clo. The results showed that the PHS model generated unreliable predictions on body core temperature when human subjects wore thick protective clothing such as firefighting clothing (I(cl) > 1.0 clo). The predicted mean skin temperatures in three clothing ensembles HV, MIL and FIRE were also outside the expected limits. Thus, there is a need for further extension for the clothing insulation validation range of the PHS model. It is recommended that the PHS model should be amended and validated by individual algorithms, physical or physiological parameters, and further subject studies.

77 FR 13132 - Proposed Collection: Comment Request; Revision “PHS Applications and Pre-Award Reporting...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-05

... individuals to indicate the start of their NRSA awards. The PHS 6031 Payback Agreement is used by individuals... activated and trainees appointed. Affected Public: Universities and other research institutions; Business or...

42 CFR 93.213 - Institution.

Code of Federal Regulations, 2013 CFR

2013-10-01

... receives PHS support for any activity or program that involves the conduct of biomedical or behavioral research, biomedical or behavioral research training, or activities related to that research or training. This includes, but is not limited to colleges and universities, PHS intramural biomedical or behavioral...

42 CFR 93.213 - Institution.

Code of Federal Regulations, 2014 CFR

2014-10-01

... receives PHS support for any activity or program that involves the conduct of biomedical or behavioral research, biomedical or behavioral research training, or activities related to that research or training. This includes, but is not limited to colleges and universities, PHS intramural biomedical or behavioral...

42 CFR 93.213 - Institution.

Code of Federal Regulations, 2012 CFR

2012-10-01

... receives PHS support for any activity or program that involves the conduct of biomedical or behavioral research, biomedical or behavioral research training, or activities related to that research or training. This includes, but is not limited to colleges and universities, PHS intramural biomedical or behavioral...

42 CFR 93.213 - Institution.

Code of Federal Regulations, 2010 CFR

2010-10-01

... receives PHS support for any activity or program that involves the conduct of biomedical or behavioral research, biomedical or behavioral research training, or activities related to that research or training. This includes, but is not limited to colleges and universities, PHS intramural biomedical or behavioral...

45 CFR 94.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... affect the design, conduct, or reporting of PHS-funded research. FCOI report means an Institution's... (excluding a Federal agency) that submits a proposal, or that receives, PHS research funding. Institutional... by the Institution in its policy on financial conflicts of interest, which may include for example...

45 CFR 94.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... affect the design, conduct, or reporting of PHS-funded research. FCOI report means an Institution's... (excluding a Federal agency) that submits a proposal, or that receives, PHS research funding. Institutional... by the Institution in its policy on financial conflicts of interest, which may include for example...

45 CFR 94.3 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... affect the design, conduct, or reporting of PHS-funded research. FCOI report means an Institution's... (excluding a Federal agency) that submits a proposal, or that receives, PHS research funding. Institutional... by the Institution in its policy on financial conflicts of interest, which may include for example...

45 CFR 94.3 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... affect the design, conduct, or reporting of PHS-funded research. FCOI report means an Institution's... (excluding a Federal agency) that submits a proposal, or that receives, PHS research funding. Institutional... by the Institution in its policy on financial conflicts of interest, which may include for example...

Phytosphingosine degradation pathway includes fatty acid α-oxidation reactions in the endoplasmic reticulum.

PubMed

Kitamura, Takuya; Seki, Naoya; Kihara, Akio

2017-03-28

Although normal fatty acids (FAs) are degraded via β-oxidation, unusual FAs such as 2-hydroxy (2-OH) FAs and 3-methyl-branched FAs are degraded via α-oxidation. Phytosphingosine (PHS) is one of the long-chain bases (the sphingolipid components) and exists in specific tissues, including the epidermis and small intestine in mammals. In the degradation pathway, PHS is converted to 2-OH palmitic acid and then to pentadecanoic acid (C15:0-COOH) via FA α-oxidation. However, the detailed reactions and genes involved in the α-oxidation reactions of the PHS degradation pathway have yet to be determined. In the present study, we reveal the entire PHS degradation pathway: PHS is converted to C15:0-COOH via six reactions [phosphorylation, cleavage, oxidation, CoA addition, cleavage (C1 removal), and oxidation], in which the last three reactions correspond to the α-oxidation. The aldehyde dehydrogenase ALDH3A2 catalyzes both the first and second oxidation reactions (fatty aldehydes to FAs). In Aldh3a2 -deficient cells, the unmetabolized fatty aldehydes are reduced to fatty alcohols and are incorporated into ether-linked glycerolipids. We also identify HACL2 (2-hydroxyacyl-CoA lyase 2) [previous name, ILVBL; ilvB (bacterial acetolactate synthase)-like] as the major 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the FA α-oxidation of the PHS degradation pathway. HACL2 is localized in the endoplasmic reticulum. Thus, in addition to the already-known FA α-oxidation in the peroxisomes, we have revealed the existence of FA α-oxidation in the endoplasmic reticulum in mammals.

The wheat Phs-A1 pre-harvest sprouting resistance locus delays the rate of seed dormancy loss and maps 0.3 cM distal to the PM19 genes in UK germplasm

PubMed Central

Shorinola, Oluwaseyi; Bird, Nicholas; Simmonds, James; Berry, Simon; Henriksson, Tina; Jack, Peter; Werner, Peter; Gerjets, Tanja; Scholefield, Duncan; Balcárková, Barbara; Valárik, Miroslav; Holdsworth, M. J.; Flintham, John; Uauy, Cristobal

2016-01-01

The precocious germination of cereal grains before harvest, also known as pre-harvest sprouting, is an important source of yield and quality loss in cereal production. Pre-harvest sprouting is a complex grain defect and is becoming an increasing challenge due to changing climate patterns. Resistance to sprouting is multi-genic, although a significant proportion of the sprouting variation in modern wheat cultivars is controlled by a few major quantitative trait loci, including Phs-A1 in chromosome arm 4AL. Despite its importance, little is known about the physiological basis and the gene(s) underlying this important locus. In this study, we characterized Phs-A1 and show that it confers resistance to sprouting damage by affecting the rate of dormancy loss during dry seed after-ripening. We show Phs-A1 to be effective even when seeds develop at low temperature (13 °C). Comparative analysis of syntenic Phs-A1 intervals in wheat and Brachypodium uncovered ten orthologous genes, including the Plasma Membrane 19 genes (PM19-A1 and PM19-A2) previously proposed as the main candidates for this locus. However, high-resolution fine-mapping in two bi-parental UK mapping populations delimited Phs-A1 to an interval 0.3 cM distal to the PM19 genes. This study suggests the possibility that more than one causal gene underlies this major pre-harvest sprouting locus. The information and resources reported in this study will help test this hypothesis across a wider set of germplasm and will be of importance for breeding more sprouting resilient wheat varieties. PMID:27217549

Maintenance and regulation of the pH microclimate at the luminal surface of the distal colon of guinea-pig

PubMed Central

Genz, Anne-Katrin; v Engelhardt, Wolfgang; Busche, Roger

1999-01-01

The fluorescent dye 5-N-hexadecanoyl-aminofluorescein (HAF) was used to study the mechanisms involved in maintaining a relatively constant luminal surface pH (pHs) in the distal colon of the guinea-pig. The fatty acyl chain of the HAF molecule inserts into the apical membrane of epithelial cells. This allows a continuous measurement of the surface pH for several hours. The localization of HAF was confirmed by confocal laser-scanning microscopy and by using monoclonal antibodies against fluorescein. The insertion of HAF into the apical membrane of the colonocytes did not change the transepithelial conductance or the short-circuit current of the epithelium. With the HAF method a pH microclimate was confirmed at the colonic surface. Although the pH of the bulk luminal solution was decreased in bicarbonate-containing solution from 7.4 to 6.4 the pHs changed only in the range 7.54-6.98. In the absence of bicarbonate pHs almost followed changes of bulk luminal pH. In the presence of bicarbonate there was a decrease in pHs after removal of chloride from the luminal side and an increase in pHs after addition of butyrate to the luminal solution. This suggests the involvement of a bicarbonate-anion exchange in bicarbonate secretion: a Cl−-HCO3− as well as a short-chain fatty acid−-HCO3− exchange. The apical K+-H+-ATPase in the distal colon of guinea-pig has little influence on pHs in the presence of physiological buffer concentrations. Our findings indicate that bicarbonate plays a major role in maintaining the pH microclimate at the colonic surface. PMID:10332098

Metabolism of phenol and hydroquinone to reactive products by macrophage peroxidase or purified prostaglandin H synthase

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schlosser, M.J.; Shurina, R.D.; Kalf, G.F.

1989-07-01

Macrophages, an important cell-type of the bone marrow stroma, are possible targets of benzene toxicity because they contain relatively large amounts of prostaglandin H synthase (PHS), which is capable of metabolizing phenolic compounds to reactive species. PHS also catalyzes the production of prostaglandins, negative regulators of myelopoiesis. Studies indicate that the phenolic metabolites of benzene are oxidized in bone marrow to reactive products via peroxidases. With respect to macrophages, PHS peroxidase is implicated, as in vivo benzene-induced myelotoxicity is prevented by low doses of nonsteroidal anti-inflammatory agents, drugs that inhibit PHS. Incubations of either 14C-phenol or 14C-hydroquinone with a lysatemore » of macrophages collected from mouse peritoneum (greater than 95% macrophages), resulted in an irreversible binding to protein that was dependent upon H2O2, incubation time, and concentration of radiolabel. Production of protein-bound metabolites from phenol or hydroquinone was inhibited by the peroxidase inhibitor aminotriazole. Protein binding from 14C-phenol also was inhibited by 8 microM hydroquinone, whereas binding from 14C-hydroquinone was stimulated by 5 mM phenol. The nucleophile cysteine inhibited protein binding of both phenol and hydroquinone and increased the formation of radiolabeled water-soluble metabolites. Similar to the macrophage lysate, purified PHS also catalyzed the conversion of phenol to metabolites that bound to protein and DNA; this activation was both H2O2- and arachidonic acid-dependent. These results indicate a role for macrophage peroxidase, possibly PHS peroxidase, in the conversion of phenol and hydroquinone to reactive metabolites and suggest that the macrophage should be considered when assessing the hematopoietic toxicity of benzene.« less

42 CFR 50.603 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Promoting Objectivity in Research § 50.603 Definitions. As used in this subpart: Disclosure of significant... significantly affect the design, conduct, or reporting of PHS-funded research. FCOI report means an Institution... (excluding a Federal agency) that is applying for, or that receives, PHS research funding. Institutional...

42 CFR 50.603 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Promoting Objectivity in Research § 50.603 Definitions. As used in this subpart: Disclosure of significant... significantly affect the design, conduct, or reporting of PHS-funded research. FCOI report means an Institution... (excluding a Federal agency) that is applying for, or that receives, PHS research funding. Institutional...

42 CFR 50.603 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Promoting Objectivity in Research § 50.603 Definitions. As used in this subpart: Disclosure of significant... significantly affect the design, conduct, or reporting of PHS-funded research. FCOI report means an Institution... (excluding a Federal agency) that is applying for, or that receives, PHS research funding. Institutional...

42 CFR 50.603 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Promoting Objectivity in Research § 50.603 Definitions. As used in this subpart: Disclosure of significant... significantly affect the design, conduct, or reporting of PHS-funded research. FCOI report means an Institution... (excluding a Federal agency) that is applying for, or that receives, PHS research funding. Institutional...

45 CFR 94.5 - Management and reporting of financial conflicts of interest.

Code of Federal Regulations, 2012 CFR

2012-10-01

... a PHS-funded research project, the designated official(s) of an Institution shall, consistent with... any significant financial interests relate to PHS-funded research; determine whether a financial... publishing the research); (ii) For research projects involving human subjects research, disclosure of...

45 CFR 94.5 - Management and reporting of financial conflicts of interest.

Code of Federal Regulations, 2011 CFR

2011-10-01

... a PHS-funded research project, the designated official(s) of an Institution shall, consistent with... any significant financial interests relate to PHS-funded research; determine whether a financial... publishing the research); (ii) For research projects involving human subjects research, disclosure of...

45 CFR 94.5 - Management and reporting of financial conflicts of interest.

Code of Federal Regulations, 2013 CFR

2013-10-01

... a PHS-funded research project, the designated official(s) of an Institution shall, consistent with... any significant financial interests relate to PHS-funded research; determine whether a financial... publishing the research); (ii) For research projects involving human subjects research, disclosure of...

45 CFR 94.5 - Management and reporting of financial conflicts of interest.

Code of Federal Regulations, 2014 CFR

2014-10-01

... a PHS-funded research project, the designated official(s) of an Institution shall, consistent with... any significant financial interests relate to PHS-funded research; determine whether a financial... publishing the research); (ii) For research projects involving human subjects research, disclosure of...

42 CFR 50.601 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Responsibility of Applicants for Promoting Objectivity in Research for Which PHS Funding Is Sought § 50.601 Purpose. This subpart promotes objectivity in research by establishing standards to ensure there is no reasonable expectation that the design, conduct, or reporting of research funded under PHS grants or...

Age of the Subducting Philippine Sea Slab and Mechanism of Low-Frequency Earthquakes

NASA Astrophysics Data System (ADS)

Hua, Yuanyuan; Zhao, Dapeng; Xu, Yixian; Liu, Xin

2018-03-01

Nonvolcanic low-frequency earthquakes (LFEs) usually occur in young and warm subduction zones under condition of near-lithostatic pore fluid pressure. However, the relation between the LFEs and the subducting slab age has never been documented so far. Here we estimate the lithospheric age of the subducting Philippine Sea (PHS) slab beneath the Nankai arc by linking seismic tomography and a plate reconstruction model. Our results show that the LFEs in SW Japan take place in young parts ( 17-26 Myr) of the PHS slab. However, no LFE occurs beneath the Kii channel where the PHS slab is very young ( 15 Myr) and thin ( 29 km), forming an LFE gap there. According to the present results and previous works, we think that the LFE gap at the Kii channel is caused by joint effects of several factors, including the youngest slab age, high temperature, low fluid content, high permeability of the overlying plate, a slab tear, and hot upwelling flow below the PHS slab.

Exploring interactions between payment for hydrologic service policies, landowner decisions, and ecohydrology in a Mexican cloud forest watershed: Is there a disconnect between the policy and the resource?

NASA Astrophysics Data System (ADS)

Asbjornsen, H.; Geissert, D.; Gomez-Tagle, A.; Holwerda, F.; Manson, R.; Perez-Maqueo, O.; Munoz-Villers, L.; Scullion, J.

2013-05-01

Payment for hydrologic service (PHS) programs are increasingly being used as a means to incentivize watershed protection by compensating upstream 'water producers' with payments made by downstream 'water consumers'. However, the effectiveness of PHS programs in achieving their target goals is often poorly understood. Here, we draw from insights obtained from socioeconomic and ecohydrological research in Veracruz, Mexico to explore interactions between PHS policies, landowner decisions, and hydrologic services. GIS analysis of land-cover changes during 2003-2009 combined with interviews of PHS participants indicated that despite lower deforestation rates on properties receiving PES payments, other factors were likely to have a greater influence on land use decisions than PHS payments per se, including opportunity costs and personal conservation ethic. The interviews also highlighted a general lack of trust and cooperation between the citizen participants and government administrators, which was reflected in the relatively low level of knowledge of the PHS programs' regulations and goals, the role of forests in protecting water resources, and a low level of co-financing by the private sector. An important premise of PHS programs is that protecting existing forest cover (and planting trees) will enhance water supply, especially in upland cloud forests that are due to their perceived role as water producers. Measurements of climate, steamflow, canopy fog interception, plant transpiration, soil water dynamics, and hydrologic flow paths were collected over a 3-year period to assess stand water balance and streamflow response under four different land covers: mature cloud forest, pasture, regenerating cloud forest, pine reforestation. Results suggested relatively minor additional inputs of fog to increasing streamflow in cloud forest watersheds, while conversion of forest to pasture did not markedly decrease dry season flows, but did increase annual flows due to lower pasture evapotranspiration. Nevertheless, the pasture showed higher surface runoff for the most intense storms, indicating a diminished infiltration capacity. Young pine plantations and regenerating cloud forest had higher evapotranspiration and therefore higher water yield relative to mature cloud forest. Our analysis suggests a disconnect between PHS policies and the hydrological services provided through forest conservation and tree planting. The implications of this apparent disconnect are discussed within the context of designing effective policies for enhancing hydrologic services, and the importance of site-based research and monitoring to improve understanding of coupled social-ecohydrological systems.

Tottori earthquakes and Daisen volcano: Effects of fluids, slab melting and hot mantle upwelling

NASA Astrophysics Data System (ADS)

Zhao, Dapeng; Liu, Xin; Hua, Yuanyuan

2018-03-01

We investigate the 3-D seismic structure of source areas of the 6 October 2000 Western Tottori earthquake (M 7.3) and the 21 October 2016 Central Tottori earthquake (M 6.6) which occurred near the Daisen volcano in SW Japan. The two large events took place in a high-velocity zone in the upper crust, whereas low-velocity (low-V) and high Poisson's ratio (high-σ) anomalies are revealed in the lower crust and upper mantle. Low-frequency micro-earthquakes (M 0.0-2.1) occur in or around the low-V and high-σ zones, which reflect upward migration of magmatic fluids from the upper mantle to the crust under the Daisen volcano. The nucleation of the Tottori earthquakes may be affected by the ascending fluids. The flat subducting Philippine Sea (PHS) slab has a younger lithosphere age and so a higher temperature beneath the Daisen and Tottori area, facilitating the PHS slab melting. It is also possible that a PHS slab window has formed along the extinct Shikoku Basin spreading ridge beneath SW Japan, and mantle materials below the PHS slab may ascend to the shallow area through the slab window. These results suggest that the Daisen adakite magma was affected by the PHS slab melting and upwelling flow in the upper mantle above the subducting Pacific slab.

Alkalinity of non-industrial cleaning products and the likelihood of producing significant esophageal burns.

PubMed

Howell, J M

1991-11-01

Alkaline cleaning products are a cause of serious esophageal injury. Over time, legislation has diminished the concentration of many such non-industrial solutions and solids; however several products presently do not list either the pH or relative concentrations of alkaline constituents. This study measures the pHs of several non-industrial cleaning products containing either ammonium chloride, sodium hydroxide, or potassium hydroxide. Three pH measurements were performed on each of 10 non-industrial alkaline cleaning products (eight liquid, two solid). Two 0.1% ammonium chloride solutions had pHs of 12.06 +/- 0.00 and 12.06 +/- 0.01, whereas a pH of 12.43 +/- 0.00 was recorded in a 0.2% ammonium chloride solution. Concentrations of sodium hydroxide and potassium hydroxide were listed on only one of five liquid cleaning product labels. The pHs for these five products varied between 12.83 +/- 0.009 and 13.5 +/- .0.2. The pHs of three sodium hydroxide solutions differed from values reported in Micromedex (Micromedex Inc, Denver CO) by up to 0.32 pH units. Ten percent (v/v) solutions of two solid lye products had pHs of 13.62 +/- 0.008 and 13.74 +/- 0.02. The investigator found that selected non-industrial cleaning products, including ammonia solutions, retain the ability to cause clinically important esophageal damage.

Phase Behavior of Binary Blends of AB+AC Block Copolymers with compatible B and C blocks

NASA Astrophysics Data System (ADS)

Pryamitsyn, Victor; Ganesan, Venkat

2012-02-01

Recently the experimental studies of phase behavior of binary blends of PS-b-P2VP and PS-b-PHS demonstrated an interesting effect: blends of symmetric PS-b-P2VP and shorter symmetric (PS-b-PHS) formed cylindrical HEX and spherical BCC phases, while each pure component formed lamellas. The miscibility of P2VP and PHS is caused by the hydrogen bonding between P2VP and PHS,which can be described as a negative Flory ?-parameter between P2VP and PHS. We developed a theory of the microphase segregation of AB+AC blends of diblock copolymers based on strong stretching theory. The main result of our theory is that in the copolymer brush-like layer formed by longer B chain and shorter C chains, the attraction between B and shorter C chains causes relative stretching of short C chains and compression of longer B chains. The latter manifests in an excessive bending force towards the grafting surface (BC|AA interface). Such bending force causes a transition from a symmetric lamella phase to a HEX cylinder or BCC spherical phases with the BC phase being a ``matrix'' component. In a blend of asymmetric BCC sphere forming copolymers (where B and C segments are the minor components), such bending force may unfold BCC spherical phase to a HEX cylinder phase, or even highly uneven lamella phases.

Congenital Hypothalamic "Hamartoblastoma" Versus "Hamartoma": Suggestions for Neuropathologic Terminology Emanating From a Mid-gestational Autopsy Case of Pallister-Hall Syndrome.

PubMed

Dunham, C; McFadden, D; Dahlgren, L; Butler, B; Hamilton, S; McKinnon, M

2018-01-01

Pallister-Hall syndrome (PHS) is a rare malformative disorder that is due to truncating functional repressor mutations in GLI3. Since the seminal publication in 1980, hypothalamic tumors have been recognized to be a cardinal feature of PHS. In their original description of the neuropathologic features of PHS, Clarren et al. coined the term "hamartoblastoma" to characterize what they deemed to be a dual malformative and neoplastic mass of the hypothalamus. In subsequent published cases/series of PHS, the term "hamartoma" was often substituted for hamartoblastoma given what appeared to be a benign natural history of this lesion. Additional confusion in the literature has ensued since most hypothalamic hamartomas (HH) encountered on the clinical neuropathology service are "isolated" in nature (ie, no other congenital malformations) and present in a very different and stereotypical fashion with gelastic seizures and/or precocious puberty. While genomic investigations of isolated HH have begun to uncover a mutational profile of these cases, GLI3 mutations have only been recognized in a small subset of isolated HH. Herein, we describe the autopsy findings from a 21-week gestational age fetus with features of PHS. Moreover, we provide a detailed description of the hypothalamic tumor affecting this fetus and propose a novel subclassification of HH, distinguishing syndromic from isolated forms based upon the presence or absence of neocortical-like areas.

Isolated intermediate-depth seismicity north of the Izu peninsula, Japan: implications for subduction of the Philippine Sea Plate

NASA Astrophysics Data System (ADS)

Nakajima, Junichi

2018-01-01

The subduction of the Philippine Sea (PHS) Plate toward the north of Izu peninsula, Japan, is of great interest because intraslab seismicity is absent where the buoyant Izu volcanic arc has been subducting over the past 15 Myr. This study analyzes 42 earthquakes in an isolated seismic cluster that occurred 100 km north of Izu peninsula at depths of 40-90 km and discusses seismogenesis in the context of plate subduction. We picked P- and S-wave arrival times of earthquakes to produce a complete hypocenter catalogue, carried out double-difference event relocations, and then determined focal mechanism solutions of 7 earthquakes from P-wave polarity data. Based on the focal mechanism solution, the largest earthquake (M3.1) is interpreted as a thrust earthquake along the upper surface of the PHS Plate. Locations of other earthquakes relative to the largest event suggest that most earthquakes occur within the subducting PHS Plate. Our results suggest that the PHS Plate north of Izu peninsula has temperatures low enough to facilitate thrust and intraslab earthquakes at depths of 60-90 km. Earthquakes are likely to occur where pore pressures are locally high, which weakens pre-existing faults. The presence of the intermediate-depth seismic cluster indicates the continuous subduction of the PHS Plate toward the north of Izu peninsula without any disruption.[Figure not available: see fulltext.

45 CFR 94.6 - Remedies.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 1 2012-10-01 2012-10-01 false Remedies. 94.6 Section 94.6 Public Welfare..., conduct, or reporting of the PHS-funded research, the Institution shall promptly notify the PHS Awarding... Remedies. (a) If the failure of an Investigator to comply with an Institution's financial conflicts of...

45 CFR 94.6 - Remedies.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 1 2013-10-01 2013-10-01 false Remedies. 94.6 Section 94.6 Public Welfare..., conduct, or reporting of the PHS-funded research, the Institution shall promptly notify the PHS Awarding... Remedies. (a) If the failure of an Investigator to comply with an Institution's financial conflicts of...

45 CFR 94.6 - Remedies.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 1 2014-10-01 2014-10-01 false Remedies. 94.6 Section 94.6 Public Welfare..., conduct, or reporting of the PHS-funded research, the Institution shall promptly notify the PHS Awarding... Remedies. (a) If the failure of an Investigator to comply with an Institution's financial conflicts of...

42 CFR 93.220 - Public Health Service or PHS.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Public Health Service or PHS. 93.220 Section 93.220 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON...

42 CFR 93.220 - Public Health Service or PHS.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Public Health Service or PHS. 93.220 Section 93.220 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON...

42 CFR 93.220 - Public Health Service or PHS.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Health, and the Substance Abuse and Mental Health Services Administration, and the offices of the... 42 Public Health 1 2012-10-01 2012-10-01 false Public Health Service or PHS. 93.220 Section 93.220 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND...

42 CFR 93.220 - Public Health Service or PHS.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Health, and the Substance Abuse and Mental Health Services Administration, and the offices of the... 42 Public Health 1 2013-10-01 2013-10-01 false Public Health Service or PHS. 93.220 Section 93.220 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND...

42 CFR 93.220 - Public Health Service or PHS.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Health, and the Substance Abuse and Mental Health Services Administration, and the offices of the... 42 Public Health 1 2011-10-01 2011-10-01 false Public Health Service or PHS. 93.220 Section 93.220 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND...

28 CFR 91.68 - Compliance with other Federal environmental statutes, regulations and executive orders.

Code of Federal Regulations, 2014 CFR

2014-07-01

... regulations, and the relevant executive orders: (1) Archeological and Historical Preservation Act, (2) Coastal Zone Management Act, (3) Coastal Barrier Resources Act, (4) Clean Air Act, (5) Safe Drinking Water Act..., (9) National Historic Preservation Act, (10) Wilderness Act, (11) Farmland Protection Policy Act, (12...

28 CFR 91.68 - Compliance with other Federal environmental statutes, regulations and executive orders.

Code of Federal Regulations, 2013 CFR

2013-07-01

... regulations, and the relevant executive orders: (1) Archeological and Historical Preservation Act, (2) Coastal Zone Management Act, (3) Coastal Barrier Resources Act, (4) Clean Air Act, (5) Safe Drinking Water Act..., (9) National Historic Preservation Act, (10) Wilderness Act, (11) Farmland Protection Policy Act, (12...

28 CFR 91.68 - Compliance with other Federal environmental statutes, regulations and executive orders.

Code of Federal Regulations, 2011 CFR

2011-07-01

... regulations, and the relevant executive orders: (1) Archeological and Historical Preservation Act, (2) Coastal Zone Management Act, (3) Coastal Barrier Resources Act, (4) Clean Air Act, (5) Safe Drinking Water Act..., (9) National Historic Preservation Act, (10) Wilderness Act, (11) Farmland Protection Policy Act, (12...

28 CFR 91.68 - Compliance with other Federal environmental statutes, regulations and executive orders.

Code of Federal Regulations, 2012 CFR

2012-07-01

... regulations, and the relevant executive orders: (1) Archeological and Historical Preservation Act, (2) Coastal Zone Management Act, (3) Coastal Barrier Resources Act, (4) Clean Air Act, (5) Safe Drinking Water Act..., (9) National Historic Preservation Act, (10) Wilderness Act, (11) Farmland Protection Policy Act, (12...

28 CFR 91.68 - Compliance with other Federal environmental statutes, regulations and executive orders.

Code of Federal Regulations, 2010 CFR

2010-07-01

... regulations, and the relevant executive orders: (1) Archeological and Historical Preservation Act, (2) Coastal Zone Management Act, (3) Coastal Barrier Resources Act, (4) Clean Air Act, (5) Safe Drinking Water Act..., (9) National Historic Preservation Act, (10) Wilderness Act, (11) Farmland Protection Policy Act, (12...

Environmental statutes, 1985 edition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1985-01-01

All major environmental laws are incorporated into a single book. The complete text of each statute as currently amended is included with a detailed Table of Contents for your quick referral. Contents: Clean Air Act; Federal Water Pollution Control Act; National Environmental Policy Act; Noise Control Act; FIFRA; Marines Sanctuaries Act; Occupational Safety and Health Act; Resource Conservation and Recovery Act including the new Hazardous and Solid Waste Amendments of 1984 with the new Leaking Underground Storage Tank law; Safe Drinking Water Act; Toxic Substances Control Act; CERCLA/Superfund; and the Used Oil Recycling Act.

75 FR 42130 - Notice of Lodging of Consent Decree Under the Clean Air Act; Clean Water Act; Resource...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-20

... DEPARTMENT OF JUSTICE Notice of Lodging of Consent Decree Under the Clean Air Act; Clean Water Act; Resource Conservation and Recovery Act; Safe Drinking Water Act; Toxic Substances Control Act; and the Reporting Requirements of the Emergency Planning and Community Right-To-Know Act and the Comprehensive Environmental Response, Compensation, and...

Cigarettes and the US Public Health Service in the 1950s.

PubMed Central

Parascandola, M

2001-01-01

The conclusion of the United States Surgeon General's Advisory Committee on Smoking and Health in 1964 that excessive cigarette smoking causes lung cancer is cited as the major turning point for public health action against cigarettes. But the surgeon general and US Public Health Service (PHS) scientists had concluded as early as 1957 that smoking was a cause of lung cancer, indeed, "the principal etiologic factor in the increased incidence of lung cancer." Throughout the 1950s, however, the PHS rejected further tobacco-related public health actions, such as placing warning labels on cigarettes or creating educational programs for schools. Instead, the agency continued to gather information and provided occasional assessments of the evidence as it came available. It was not until pressure mounted from outside the PHS in the early 1960s that more substantive action was taken. Earlier action was not taken because of the way in which PHS scientists (particularly those within the National Institutes of Health) and administrators viewed their roles in relation to science and public health. PMID:11211627

Exploring Preconception Care: Insurance Status, Race/Ethnicity, and Health in the Pre-pregnancy Period.

PubMed

Hawks, Rebecca Mahn; McGinn, Aileen P; Bernstein, Peter S; Tobin, Jonathan N

2018-02-20

Objective To measure the association of preconception health insurance status with preconception health among women in New York City, and examine whether this association is modified by race/ethnicity. Methods Using data from the New York City Pregnancy Risk Assessment Monitoring System 2009-2011 (n = 3929), we created a "Preconception Health Score" (PHS) capturing modifiable behaviors, healthcare services utilization, pregnancy intention, and timely entry into prenatal care. We then built multivariable logistic regression models to measure the association of PHS with health insurance status and race/ethnicity. Results We found PHS to be higher among women with private insurance (7.3 ± 0.07) or public insurance (6.3 ± 0.08) before pregnancy than no insurance (5.9 ± 0.09) (p < .001). However, when stratified by race/ethnicity, the positive association of PHS with insurance was absent in the non-white population. Conclusions for Practice Having health insurance during the pre-pregnancy period is associated with greater health among white women, but not among black or Hispanic women in NYC.

Prevention of Preharvest Sprouting through Hormone Engineering and Germination Recovery by Chemical Biology.

PubMed

Nonogaki, Mariko; Nonogaki, Hiroyuki

2017-01-01

Vivipary, germination of seeds on the maternal plant, is observed in nature and provides ecological advantages in certain wild species, such as mangroves. However, precocious seed germination in agricultural species, such as preharvest sprouting (PHS) in cereals, is a serious issue for food security. PHS reduces grain quality and causes economical losses to farmers. PHS can be prevented by translating the basic knowledge of hormone biology in seeds into technologies. Biosynthesis of abscisic acid (ABA), which is an essential hormone for seed dormancy, can be engineered to enhance dormancy and prevent PHS. Enhancing nine- cis -epoxycarotenoid dioxygenase (NCED), a rate-limiting enzyme of ABA biosynthesis, through a chemically induced gene expression system, has successfully been used to suppress germination of Arabidopsis seeds. The more advanced system NCED positive-feedback system, which amplifies ABA biosynthesis in a seed-specific manner without chemical induction, has also been developed. The proofs of concept established in the model species are now ready to be applied to crops. A potential problem is recovery of germination from hyperdormant crop grains. Hyperdormancy induced by the NCED systems can be reversed by inducing counteracting genes, such as NCED RNA interference or gibberellin (GA) biosynthesis genes. Alternatively, seed sensitivity to ABA can be modified to rescue germination using the knowledge of chemical biology. ABA antagonists, which were developed recently, have great potential to recover germination from the hyperdormant seeds. Combination of the dormancy-imposing and -releasing approaches will establish a comprehensive technology for PHS prevention and germination recovery.

Spatiotemporal Monte Carlo transport methods in x-ray semiconductor detectors: application to pulse-height spectroscopy in a-Se.

PubMed

Fang, Yuan; Badal, Andreu; Allec, Nicholas; Karim, Karim S; Badano, Aldo

2012-01-01

The authors describe a detailed Monte Carlo (MC) method for the coupled transport of ionizing particles and charge carriers in amorphous selenium (a-Se) semiconductor x-ray detectors, and model the effect of statistical variations on the detected signal. A detailed transport code was developed for modeling the signal formation process in semiconductor x-ray detectors. The charge transport routines include three-dimensional spatial and temporal models of electron-hole pair transport taking into account recombination and trapping. Many electron-hole pairs are created simultaneously in bursts from energy deposition events. Carrier transport processes include drift due to external field and Coulombic interactions, and diffusion due to Brownian motion. Pulse-height spectra (PHS) have been simulated with different transport conditions for a range of monoenergetic incident x-ray energies and mammography radiation beam qualities. Two methods for calculating Swank factors from simulated PHS are shown, one using the entire PHS distribution, and the other using the photopeak. The latter ignores contributions from Compton scattering and K-fluorescence. Comparisons differ by approximately 2% between experimental measurements and simulations. The a-Se x-ray detector PHS responses simulated in this work include three-dimensional spatial and temporal transport of electron-hole pairs. These PHS were used to calculate the Swank factor and compare it with experimental measurements. The Swank factor was shown to be a function of x-ray energy and applied electric field. Trapping and recombination models are all shown to affect the Swank factor.

Differences in Cardiovascular Disease Risk Factors and Health Behaviors Between Black and Non-Black Students Participating in a School-Based Health Promotion Program.

PubMed

Jamerson, Taylor; Sylvester, Rachel; Jiang, Qingmei; Corriveau, Nicole; DuRussel-Weston, Jean; Kline-Rogers, Eva; Jackson, Elizabeth A; Eagle, Kim A

2017-07-01

To compare cardiovascular disease (CVD) risk factors of black and non-black children participating in Project Healthy Schools (PHS), a school-based wellness program. Participants were surveyed and participated in physiological screenings pre- and post-PHS intervention. Middle schools in 4 Michigan communities of varying socioeconomic status. A total of 3813 sixth-grade students comprised the survey sample, and 2297 sixth-grade students comprised the screening sample. Project Healthy Schools is a school-based intervention designed to reduce the risk of obesity and CVD in children through the promotion of healthy eating and physical activity. Physical examination, blood test, and self-reported survey data on dietary habits, physical activity, and sedentary behaviors were collected pre- and post-PHS. Paired and independent t tests were used for physiologic variables. Wilcoxon sign-rank and rank-sum tests were used for survey variables. At baseline, blacks had a higher percentage of overweight/obese students (43% vs 34%; P < .0001) and demonstrated poorer health habits than non-blacks; however, non-blacks had poorer lipid profiles. At follow-up (post-PHS intervention), both groups demonstrated significant improvements in physiological measures and health behaviors. Despite disparities between the groups at both baseline and follow-up, changes seen post-PHS intervention were beneficial in both groups. These results suggest that early intervention for risk factor modification is possible and may be of great importance in the prevention of CVD, particularly in high-risk groups.

29 CFR 24.111 - Withdrawal of complaints, objections, and findings; settlement.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Energy Reorganization Act, the Clean Air Act, the Safe Drinking Water Act, or the Toxic Substances... under the Energy Reorganization Act, the Clean Air Act, the Safe Drinking Water Act, and the Toxic... withdrawal. If the objections are withdrawn because of settlement under the Energy Reorganization Act, the...

75 FR 36535 - Freedom of Information Act, Privacy Act of 1974; Implementation

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-28

... Freedom of Information Act (FOIA) and its regulations concerning the Privacy Act of 1974 (Privacy Act). It..., Privacy Act of 1974; Implementation AGENCY: Department of the Treasury. ACTION: Final rule; correcting... the Privacy Act. In addition, that document revised the list of Treasury offices and bureaus found...

Assessment of Heparin Anticoagulation Measured Using i-STAT and Hemochron Activated Clotting Time.

PubMed

Maslow, Andrew; Chambers, Alison; Cheves, Tracey; Sweeney, Joseph

2018-01-31

Adequate anticoagulation, measured using activated clotting time (ACT), is important during vascular and cardiac surgeries. Unfractionated heparin is the most common anticoagulant used. The purpose of this analysis was to compare the i-STAT ACT (iACT) to the Hemochron ACT (hACT), both of which were then compared to anti-factor Xa (anti-Xa) assay, a representation of heparin level and activity. Prospective study. Tertiary care cardiovascular center. Eleven consecutive elective adult cardiac surgical patients. Prior to cardiopulmonary bypass, ACTs were measured using i-STAT and Hemochron technologies and compared to each other and to anti-Xa assay prior to and during a cumulative administration of heparin. Data were compared using bias analyses. Heparin (300 U/kg) was administered in quarterly doses. Coagulation labs were collected prior to and 3 minutes after each quarterly dose of heparin. The baseline ACTs for i-STAT and Hemochron were 147 and 142 seconds, respectively. A significant association was found between iACT and hACT (p = 0.002). The iACT measurements underestimated hACT at ACT levels >180 seconds or anti-Xa levels >0.75 U/mL. No significant difference was found between ACT data at anti-Xa levels <0.5 U/mL. There was a good association between the iACT and hACT; however, the 2 tests are not equivalent. Overall, the iACT underestimated the hACT. Agreement between the ACT technologies was good at lower ACTs and anti-Xa levels, but declined with an anti-Xa >0.75 U/mL. Copyright © 2018 Elsevier Inc. All rights reserved.

Comparing performance of methods used to identify pregnant women, pregnancy outcomes, and child mortality in the Iganga-Mayuge Health and Demographic Surveillance Site, Uganda.

PubMed

Kadobera, Daniel; Waiswa, Peter; Peterson, Stefan; Blencowe, Hannah; Lawn, Joy; Kerber, Kate; Tumwesigye, Nazarius Mbona

2017-01-01

In most low and middle-income countries vital events registration for births and child deaths is poor, with reporting of pregnancy outcomes highly inadequate or non-existent. Health and Demographic Surveillance System (HDSS) sites and periodic population-based household-level surveys can be used to identify pregnancies and retrospectively capture pregnancy outcomes to provide data for decision making. However, little is known about the performance of different methods in identifying pregnancy and pregnancy outcomes, yet this is critical in assessing improvements in reducing maternal and newborn mortality and stillbirths. To explore differences between a population-based household pregnancy survey and prospective health demographic surveillance system in identifying pregnancies and their outcomes in rural eastern Uganda. The study was done within the Iganga-Mayuge HDSS site, a member centre of the INDEPTH Network. Prospective data about pregnancies and their outcomes was collected in the routine biannual census rounds from 2006 to 2010 in the HDSS. In 2011 a cross-sectional survey using the pregnancy history survey (PHS) tool was conducted among women aged 15 to 49 years in the HDSS area. We compared differences between the HDSS biannual census updates and the PHS capture of pregnancies identified as well as neonatal and child deaths, stillbirths and abortions. A total of 10,540 women aged 15 to 49 years were interviewed during the PHS. The PHS captured 12.8% more pregnancies than the HDSS in the most recent year (2010-2011), though between 2006 and 2010 (earlier periods) the PHS captured only 137 (0.8%) more pregnancies overall. The PHS also consistently identified more stillbirths (18.2%), spontaneous abortions (94.5%) and induced abortions (185.8%) than the prospective HDSS update rounds. Surveillance sites are designed to prospectively track population-level outcomes. However, the PHS identified more pregnancy-related outcomes than the HDSS in this study. Asking about pregnancy and its outcomes may be a useful way to improve measurement of pregnancy outcomes. Further research is needed to identify the most effective methods of improving the capture of pregnancies and their outcomes within HDSS sites, household surveys and routine health information systems.

Tectonics of the Philippine Sea Plate as Seen From GPS Observations

NASA Astrophysics Data System (ADS)

Kato, T.; Kotake, Y.

2002-12-01

We analyzed the Global Positioning System (GPS) data in and around the Philippine Sea plate (PHS) to provide a velocity field for discussing tectonics of the plate and the mechanism of subduction process around PHS. In the present study, first, we revised the previously determined Euler vector of PHS relative to stable Eurasia using newly obtained data. Eastern part of Europe was assumed to be in a rigid block according to Nocquet et al. (2001) and we estimated the seven parameters of Helmert Transformation of this block relative to ITRF97. Then these parameters were used to estimate the Euler vector of PHS relative to stable Eurasia. For this purpose, we re-analyzed GPS data of up until 2001 at Chichi-jima, Okino-Tori Shima, Minami-Daito, Palau, Aogashima and Hachijo islands in ITRF97 reference together with surrounding IGS sites. Results suggest that the Euler vector of PHS relative to _gstable Eurasia_h is to be (61.4N, 163.7E, 1.003deg/my). Contrary to our previous estimate, the result suggests that Palau may be considered as in the rigid part of PHS. In contrast, the northern Izu islands are suggested to be affected by local volcanic disturbances. Then, we studied tectonic motions of Mariana arc and Palau-Yap arc. The Mariana Islands have been repeatedly observed since 1992. Kotake (2000) analyzed data at Anatahan, Guguan, Pagan and Agrigan as well as Saipan and Guam sites and showed that the velocities are much slower than what we expect from rigid motion of PHS. Residual velocities at these islands clearly show eastward motion of the Mariana Islands, suggesting that the Mariana Islands are subject to the spreading of the Mariana Trough. The rotation pole of the Mariana block was re-estimated as (20.6N, 145.2E) and angular velocity to be 4.17deg/ma, according to the re-estimated PHS motion. The position of the rotation pole is a few degrees south to the geographical hinge point of the Mariana arc and west Mariana ridge at about 24N. Estimated eastward velocities at these islands are consistent with those estimated from magnetic anomaly observations. Small arc parallel extension of about 1cm/yr between Agrigan and Guam suggest that the formation of the arc is not simple fan-shape expansion, as was indicated by Karig et al. (1978). Convergence at Yap trench has also been studied using GPS. Motions of Uliti and Fais suggest slight convergence at Yap trench with about 1cm/yr, but have some northward component relative to the trench.

76 FR 64115 - Privacy Act of 1974; Privacy Act System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-17

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (11-092)] Privacy Act of 1974; Privacy Act... retirement of one Privacy Act system of records notice. SUMMARY: In accordance with the Privacy Act of 1974, NASA is giving notice that it proposes to cancel the following Privacy Act system of records notice...

75 FR 743 - Freedom of Information Act, Privacy Act of 1974; Implementation

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-06

... of Information Act (FOIA) and its regulations concerning the Privacy Act of 1974 (Privacy Act). It..., Privacy Act of 1974; Implementation AGENCY: Department of the Treasury. ACTION: Final rule. SUMMARY: This... implement the Privacy Act. In addition, the document revises the list of Treasury offices and bureaus found...

Ramifications of the Family and Medical Leave Act of 1993.

PubMed

Luecke, R W; Wise, R J; List, M S

1993-08-01

Six months ago, the Family and Medical Leave Act of 1993 was signed into law, and key provisions of the act became effective on August 5, 1993. This article examines the main provisions of the act, explains how employee leaves will be granted in compliance with the act, outlines the consequences of noncompliance with the act, analyzes the operational ramifications of the act, quantifies the financial implications of the act, and discusses the role of the healthcare financial manager in assisting with the formulation of a hospital policy to comply with the act.

Improving genomic prediction for pre-harvest sprouting tolerance in wheat by weighting large-effect quantitative trait loci

USDA-ARS?s Scientific Manuscript database

Pre-harvest sprouting (PHS) is a major problem in wheat (Triticum aestivum L.) that occurs when grains in a mature spike germinate prior to harvest, resulting in reduced yield, quality, and grain sale price. Improving PHS tolerance (PHST) is a challenge to wheat breeders because it is quantitatively...

Unravling Key metabolomic alterations of embryos derived from water-imbibed seeds of two wheat cultivars contrasting with contrasting dormancy status

USDA-ARS?s Scientific Manuscript database

Untimely rains in wheat fields during harvest season can cause pre-harvest sprouting (PHS) which deteriorates yield and quality of the crop. Metabolic homeostasis of embryo and endosperm plays a role in seed dormancy, and determines the status of the maturing grains either as dormant (PHS-tolerant) ...

Beneficial effects of protein hydrolysates in exercise and sports nutrition.

PubMed

Yuan, J; Jiang, B; Li, K; Shen, W; Tang, J L

2017-01-01

Protein hydrolysates (PH) are rich sources of proteins that supply the need of exercising muscles. PHs are enriched in di- and tripeptides and are better than free amino acids or intact proteins when muscle anabolic effect is considered. Digestion, absorption and muscle uptake of amino acids are faster and more efficient when PH is ingested in comparison to the respective intact protein. PHs not only enhance endurance in high intensity exercise regimen, but also help in faster post-exercise recovery of muscle by promoting glycogen synthesis, although the latter effect requires more convincing evidence. PHs have been shown to exhibit insulinotrophic effect as it enhances the secretion of insulin and the hormone, in turn, exerts muscle anabolic effect.

29 CFR 790.1 - Introductory statement.

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the public interest in 6 enforcement of the law will seek to apply it. As has been the case in the... Walsh-Healey Public Contracts Act, and the Bacon-Davis Act. The Portal Act also establishes time... Act. The effect of the Portal Act in relation to the Walsh-Healey Act and the Bacon-Davis Act is not...

29 CFR 825.100 - The Family and Medical Leave Act.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 3 2012-07-01 2012-07-01 false The Family and Medical Leave Act. 825.100 Section 825.100... THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Coverage Under the Family and Medical Leave Act § 825.100 The Family and Medical Leave Act. (a) The Family and Medical Leave Act of 1993, as amended, (FMLA or Act...

29 CFR 825.100 - The Family and Medical Leave Act.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 3 2013-07-01 2013-07-01 false The Family and Medical Leave Act. 825.100 Section 825.100... THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Coverage Under the Family and Medical Leave Act § 825.100 The Family and Medical Leave Act. (a) The Family and Medical Leave Act of 1993, as amended, (FMLA or Act...

29 CFR 825.100 - The Family and Medical Leave Act.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 3 2014-07-01 2014-07-01 false The Family and Medical Leave Act. 825.100 Section 825.100... THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Coverage Under the Family and Medical Leave Act § 825.100 The Family and Medical Leave Act. (a) The Family and Medical Leave Act of 1993, as amended, (FMLA or Act...

29 CFR 825.100 - The Family and Medical Leave Act.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 3 2011-07-01 2011-07-01 false The Family and Medical Leave Act. 825.100 Section 825.100... THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Coverage Under the Family and Medical Leave Act § 825.100 The Family and Medical Leave Act. (a) The Family and Medical Leave Act of 1993, as amended, (FMLA or Act...

29 CFR 1601.2 - Terms defined in title VII of the Civil Rights Act, the Americans with Disabilities Act, and the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... Americans with Disabilities Act, and the Genetic Information Nondiscrimination Act. 1601.2 Section 1601.2... Disabilities Act, and the Genetic Information Nondiscrimination Act. The terms person, employer, employment... Disabilities Act of 1990. The term genetic information shall have the meaning set forth in section 201 of the...

29 CFR 1601.2 - Terms defined in title VII of the Civil Rights Act, the Americans with Disabilities Act, and the...

Code of Federal Regulations, 2011 CFR

2011-07-01

... Americans with Disabilities Act, and the Genetic Information Nondiscrimination Act. 1601.2 Section 1601.2... Disabilities Act, and the Genetic Information Nondiscrimination Act. The terms person, employer, employment... Disabilities Act of 1990. The term genetic information shall have the meaning set forth in section 201 of the...

29 CFR 1601.2 - Terms defined in title VII of the Civil Rights Act, the Americans with Disabilities Act, and the...

Code of Federal Regulations, 2013 CFR

2013-07-01

... Americans with Disabilities Act, and the Genetic Information Nondiscrimination Act. 1601.2 Section 1601.2... Disabilities Act, and the Genetic Information Nondiscrimination Act. The terms person, employer, employment... Disabilities Act of 1990. The term genetic information shall have the meaning set forth in section 201 of the...

29 CFR 1601.2 - Terms defined in title VII of the Civil Rights Act, the Americans with Disabilities Act, and the...

Code of Federal Regulations, 2014 CFR

2014-07-01

... Americans with Disabilities Act, and the Genetic Information Nondiscrimination Act. 1601.2 Section 1601.2... Disabilities Act, and the Genetic Information Nondiscrimination Act. The terms person, employer, employment... Disabilities Act of 1990. The term genetic information shall have the meaning set forth in section 201 of the...

29 CFR 1601.2 - Terms defined in title VII of the Civil Rights Act, the Americans with Disabilities Act, and the...

Code of Federal Regulations, 2012 CFR

2012-07-01

... Americans with Disabilities Act, and the Genetic Information Nondiscrimination Act. 1601.2 Section 1601.2... Disabilities Act, and the Genetic Information Nondiscrimination Act. The terms person, employer, employment... Disabilities Act of 1990. The term genetic information shall have the meaning set forth in section 201 of the...

29 CFR 825.100 - The Family and Medical Leave Act.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false The Family and Medical Leave Act. 825.100 Section 825.100... THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Coverage Under the Family and Medical Leave Act § 825.100 The Family and Medical Leave Act. (a) The Family and Medical Leave Act of 1993, as amended, (FMLA or Act...

78 FR 15376 - Notice of Lodging of Proposed Consent Decree Amendment Under the Clean Air Act; the Clean Water...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-11

... Act; the Clean Water Act; the Resource Conservation and Recovery Act; the Emergency Planning and...'') for violations of the Clean Air Act, the Resource Conservation and Recovery Act, the Clean Water Act... Herculaneum Lead Smelter Facility 12-month rolling average limit for SO 2 emissions and the 12-month rolling...

7 CFR 1.183 - Proceedings covered.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Act of 1937 (7 U.S.C. 608c(15)(A)) Animal Health Protection Act, sections 10414 and 10415 (7 U.S.C... Information Act (7 U.S.C. 2912) Capper-Volstead Act (7 U.S.C. 292) Cotton Research and Promotion Act (7 U.S.C... Research and Promotion Act (7 U.S.C. 2620) Poultry Products Inspection Act (21 U.S.C. 455, 456, 457(d), 467...

42 CFR 417.159 - Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act...

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act and the Railway Labor Act. 417.159 Section 417.159 Public....159 Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act...

42 CFR 417.159 - Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act...

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 3 2011-10-01 2011-10-01 false Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act and the Railway Labor Act. 417.159 Section 417.159 Public....159 Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act...

Polymorphic Homoeolog of Key Gene of RdDM Pathway, ARGONAUTE4_9 class Is Associated with Pre-Harvest Sprouting in Wheat (Triticum aestivum L.)

PubMed Central

Singh, Manjit; Singh, Surinder; Randhawa, Harpinder; Singh, Jaswinder

2013-01-01

Resistance to pre-harvest sprouting (PHS) is an important objective for the genetic improvement of many cereal crops, including wheat. Resistance, or susceptibility, to PHS is mainly influenced by seed dormancy, a complex trait. Reduced seed dormancy is the most important aspect of seed germination on a spike prior to harvesting, but it is influenced by various environmental factors including light, temperature and abiotic stresses. The basic genetic framework of seed dormancy depends on the antagonistic action of abscisic acid (ABA) and gibberellic acid (GA) to promote dormancy and germination. Recent studies have revealed a role for epigenetic changes, predominantly histone modifications, in controlling seed dormancy. To investigate the role of DNA methylation in seed dormancy, we explored the role of ARGONAUTE4_9 class genes in seed development and dormancy in wheat. Our results indicate that the two wheat AGO4_9 class genes i.e. AGO802 and AGO804 map to chromosomes 3S and 1S are preferentially expressed in the embryos of developing seeds. Differential expressions of AGO802-B in the embryos of PHS resistant and susceptible varieties also relates with DNA polymorphism in various wheat varieties due to an insertion of a SINE-like element into this gene. DNA methylation patterns of the embryonic tissue from six PHS resistant and susceptible varieties demonstrate a correlation with this polymorphism. These results suggest a possible role for AGO802-B in seed dormancy and PHS resistance through the modulation of DNA methylation. PMID:24130825

Modulation of lung molecular biomarkers by beta-carotene in the Physicians' Health Study.

PubMed

Liu, Chun; Wang, Xiang-Dong; Mucci, Lorelei; Gaziano, J Michael; Zhang, Shumin M

2009-03-01

Beta-Carotene supplementation showed neither benefit nor harm among apparently healthy physicians (all men) in the Physicians' Health Study (PHS) trial. The objective of the current investigation was to evaluate how long-term beta-carotene supplementation affects molecular markers of lung carcinogenesis in the PHS. The protein levels of total p53, cyclin D1, proliferating cellular nuclear antigen (PCNA), retinoic acid receptor beta (RARbeta), and cytochrome p450 enzyme 1A1 (CYP1A1) were measured using the immunohistochemical method in 40 available archival lung tissue samples from patients who were diagnosed with lung cancer in the PHS. The protein levels of these markers were compared by category of beta-carotene treatment assignment and other characteristics using unconditional logistic regression models. The positivity for total p53, RARbeta, cyclin D1, and PCNA was nonsignificantly lower among lung cancer patients who were assigned to receive beta-carotene than those who were assigned to receive beta-carotene placebo. There was a borderline significant difference in CYP1A1 positivity with an OR of 0.2 (95% confidence interval, 0.2-1.1; P = .06) in a comparison of men who received beta-carotene and men who received beta-carotene placebo. The 50-mg beta-carotene supplementation on alternate days had no significant influence on molecular markers of lung carcinogenesis that were evaluated in the PHS. This finding provides mechanistic support for the main PHS trial results of beta-carotene, which demonstrated no benefit or harm to the risk of developing lung cancer. (c) 2009 American Cancer Society.

75 FR 28687 - Responsibility of Applicants for Promoting Objectivity in Research for Which Public Health...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-21

... regulations), that are designed to promote objectivity in PHS-funded research.\\1\\ The current regulations are... who is responsible for the design, conduct, or reporting of research (or, in the case of PHS contracts... steps to be taken to ensure that the design, conduct, and reporting of the research will not be biased...

U.S. Public Health Service Commissioned Corps pharmacists: making a difference in advancing the nation's health.

PubMed

Flowers, Louis; Wick, Jeannette; Figg, William Douglas; McClelland, Robert H; Shiber, Michael; Britton, James E; Ngo, Diem-Kieu H; Borders-Hemphill, Vicky; Mead, Christina; Zee, Jerry; Huntzinger, Paul

2009-01-01

To describe how U.S. Public Health Service (PHS) pharmacists serving in jobs that are normal for them, but considerably different than those found in the private sector, are making a difference in advancing the nation's health. Pharmacists who serve in the Commissioned Corps of PHS fill roles that are considerably different than their counterparts in the private sector. Their work takes them out from behind the counter and into the world. Pharmacy officers advance the health and safety of the nation by their involvement in the delivery of direct patient care to medically underserved people, national security, drug vigilance, research, and policy-making endeavors. PHS pharmacists fill essential public health leadership and service roles throughout the U.S. Department of Health and Human Services (HHS) and certain non-HHS federal agencies and programs. The Health Resources and Services Administration, National Institutes of Health, Federal Bureau of Prisons, Indian Health Service, Food and Drug Administration, and U.S. Coast Guard are among the many federal agencies in which pharmacy officers are assigned. In each setting, PHS pharmacists find traditional roles augmented with assignments and challenges that broaden the scope of their practice.

Metabolic response to feeding in Tupinambis merianae: circadian rhythm and a possible respiratory constraint.

PubMed

Klein, Wilfried; Perry, Steven F; Abe, Augusto S; Andrade, Denis V

2006-01-01

The diurnal tegu lizard Tupinambis merianae exhibits a marked circadian variation in metabolism that is characterized by the significant increase in metabolism during part of the day. These increases in metabolic rate, found in the fasting animal, are absent during the first 2 d after meal ingestion but reappear subsequently, and the daily increase in metabolic rate is added to the increase in metabolic rate caused by digestion. During the first 2 d after feeding, priority is given to digestion, while on the third and following days, the metabolic demands are clearly added to each other. This response seems to be a regulated response of the animal, which becomes less active after food ingestion, rather than an inability of the respiratory system to support simultaneous demands at the beginning of digestion. The body cavity of Tupinambis is divided into two compartments by a posthepatic septum (PHS). Animals that had their PHS surgically removed showed no significant alteration in the postprandial metabolic response compared to tegus with intact PHS. The maximal metabolic increment during digestion, the relative cost of meal digestion, and the duration of the process were virtually unaffected by the removal of the PHS.

New insights into genotype–phenotype correlation for GLI3 mutations

PubMed Central

Démurger, Florence; Ichkou, Amale; Mougou-Zerelli, Soumaya; Le Merrer, Martine; Goudefroye, Géraldine; Delezoide, Anne-Lise; Quélin, Chloé; Manouvrier, Sylvie; Baujat, Geneviève; Fradin, Mélanie; Pasquier, Laurent; Megarbané, André; Faivre, Laurence; Baumann, Clarisse; Nampoothiri, Sheela; Roume, Joëlle; Isidor, Bertrand; Lacombe, Didier; Delrue, Marie-Ange; Mercier, Sandra; Philip, Nicole; Schaefer, Elise; Holder, Muriel; Krause, Amanda; Laffargue, Fanny; Sinico, Martine; Amram, Daniel; André, Gwenaelle; Liquier, Alain; Rossi, Massimiliano; Amiel, Jeanne; Giuliano, Fabienne; Boute, Odile; Dieux-Coeslier, Anne; Jacquemont, Marie-Line; Afenjar, Alexandra; Van Maldergem, Lionel; Lackmy-Port-Lis, Marylin; Vincent- Delorme, Catherine; Chauvet, Marie-Liesse; Cormier-Daire, Valérie; Devisme, Louise; Geneviève, David; Munnich, Arnold; Viot, Géraldine; Raoul, Odile; Romana, Serge; Gonzales, Marie; Encha-Razavi, Ferechte; Odent, Sylvie; Vekemans, Michel; Attie-Bitach, Tania

2015-01-01

The phenotypic spectrum of GLI3 mutations includes autosomal dominant Greig cephalopolysyndactyly syndrome (GCPS) and Pallister–Hall syndrome (PHS). PHS was first described as a lethal condition associating hypothalamic hamartoma, postaxial or central polydactyly, anal atresia and bifid epiglottis. Typical GCPS combines polysyndactyly of hands and feet and craniofacial features. Genotype–phenotype correlations have been found both for the location and the nature of GLI3 mutations, highlighting the bifunctional nature of GLI3 during development. Here we report on the molecular and clinical study of 76 cases from 55 families with either a GLI3 mutation (49 GCPS and 21 PHS), or a large deletion encompassing the GLI3 gene (6 GCPS cases). Most of mutations are novel and consistent with the previously reported genotype–phenotype correlation. Our results also show a correlation between the location of the mutation and abnormal corpus callosum observed in some patients with GCPS. Fetal PHS observations emphasize on the possible lethality of GLI3 mutations and extend the phenotypic spectrum of malformations such as agnathia and reductional limbs defects. GLI3 expression studied by in situ hybridization during human development confirms its early expression in target tissues. PMID:24736735

New insights into genotype-phenotype correlation for GLI3 mutations.

PubMed

Démurger, Florence; Ichkou, Amale; Mougou-Zerelli, Soumaya; Le Merrer, Martine; Goudefroye, Géraldine; Delezoide, Anne-Lise; Quélin, Chloé; Manouvrier, Sylvie; Baujat, Geneviève; Fradin, Mélanie; Pasquier, Laurent; Megarbané, André; Faivre, Laurence; Baumann, Clarisse; Nampoothiri, Sheela; Roume, Joëlle; Isidor, Bertrand; Lacombe, Didier; Delrue, Marie-Ange; Mercier, Sandra; Philip, Nicole; Schaefer, Elise; Holder, Muriel; Krause, Amanda; Laffargue, Fanny; Sinico, Martine; Amram, Daniel; André, Gwenaelle; Liquier, Alain; Rossi, Massimiliano; Amiel, Jeanne; Giuliano, Fabienne; Boute, Odile; Dieux-Coeslier, Anne; Jacquemont, Marie-Line; Afenjar, Alexandra; Van Maldergem, Lionel; Lackmy-Port-Lis, Marylin; Vincent-Delorme, Catherine; Chauvet, Marie-Liesse; Cormier-Daire, Valérie; Devisme, Louise; Geneviève, David; Munnich, Arnold; Viot, Géraldine; Raoul, Odile; Romana, Serge; Gonzales, Marie; Encha-Razavi, Ferechte; Odent, Sylvie; Vekemans, Michel; Attie-Bitach, Tania

2015-01-01

The phenotypic spectrum of GLI3 mutations includes autosomal dominant Greig cephalopolysyndactyly syndrome (GCPS) and Pallister-Hall syndrome (PHS). PHS was first described as a lethal condition associating hypothalamic hamartoma, postaxial or central polydactyly, anal atresia and bifid epiglottis. Typical GCPS combines polysyndactyly of hands and feet and craniofacial features. Genotype-phenotype correlations have been found both for the location and the nature of GLI3 mutations, highlighting the bifunctional nature of GLI3 during development. Here we report on the molecular and clinical study of 76 cases from 55 families with either a GLI3 mutation (49 GCPS and 21 PHS), or a large deletion encompassing the GLI3 gene (6 GCPS cases). Most of mutations are novel and consistent with the previously reported genotype-phenotype correlation. Our results also show a correlation between the location of the mutation and abnormal corpus callosum observed in some patients with GCPS. Fetal PHS observations emphasize on the possible lethality of GLI3 mutations and extend the phenotypic spectrum of malformations such as agnathia and reductional limbs defects. GLI3 expression studied by in situ hybridization during human development confirms its early expression in target tissues.

43 CFR 429.2 - What definitions are used in this part?

Code of Federal Regulations, 2012 CFR

2012-10-01

... the requirements of the National Environmental Policy Act; the Endangered Species Act; the Clean Water Act; the Clean Air Act; the Comprehensive Environmental Response, Compensation, and Liability Act... Federal Water Project Recreation Act, as amended. Part 21 of this title means title 43 of the Code of...

43 CFR 429.2 - What definitions are used in this part?

Code of Federal Regulations, 2013 CFR

2013-10-01

... the requirements of the National Environmental Policy Act; the Endangered Species Act; the Clean Water Act; the Clean Air Act; the Comprehensive Environmental Response, Compensation, and Liability Act... Federal Water Project Recreation Act, as amended. Part 21 of this title means title 43 of the Code of...

43 CFR 429.2 - What definitions are used in this part?

Code of Federal Regulations, 2014 CFR

2014-10-01

... the requirements of the National Environmental Policy Act; the Endangered Species Act; the Clean Water Act; the Clean Air Act; the Comprehensive Environmental Response, Compensation, and Liability Act... Federal Water Project Recreation Act, as amended. Part 21 of this title means title 43 of the Code of...

40 CFR 25.1 - Introduction.

Code of Federal Regulations, 2011 CFR

2011-07-01

... RESOURCE CONSERVATION AND RECOVERY ACT, THE SAFE DRINKING WATER ACT, AND THE CLEAN WATER ACT § 25.1... in activities under the Clean Water Act (Pub. L. 95-217), the Resource Conservation and Recovery Act (Pub. L. 94-580), and the Safe Drinking Water Act (Pub. L. 93-523). The applicability of the...

76 FR 3098 - Privacy Act of 1974; Systems of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-19

...: National Security Agency/Central Security Service, Freedom of Information Act and Privacy Act Office, 9800..., Privacy Act and Mandatory Declassification Review Records. System Location: National Security Agency... Information Act; 5 U.S.C. 552a, The Privacy Act of 1974 (as amended); E.O. 13526, Classified National Security...

28 CFR 0.55 - General functions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Administration Act, the Federal Seed Act, the Gold Reserve Act of 1934, the Hours of Service Act, the Animal... (18 U.S.C. 1761-1762), the Safety Appliance Act, standard barrels (15 U.S.C. 231-242), the Sugar Act... Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Criminal Division...

Human Services Reauthorization Act of 1990. U.S. Senate, 101st Congress, 2d Session. Report (To Accompany H.R. 4151).

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Senate Committee on Labor and Human Resources.

The Committee on Labor and Human Resources recommends that the Human Services Reauthorization Act of 1990 be passed as amended. The Act authorizes appropriations for fiscal years 1991 through 1994 to carry out the Head Start Act, the Follow Through Act, and the Community Services Block Grant Act. Titles I through IX of the Act concern Head Start…

ACT-R Electronic Bookshelf: An Adaptive System To Support Learning ACT-R on the Web.

ERIC Educational Resources Information Center

Brusilovsky, Peter; Anderson, John

This paper describes the electronic ACT-R Bookshelf, a system which supports learning ACT-R, a well-known theory in the field of cognitive psychology, over the World Wide Web. ACT-R Bookshelf is a collection of electronic books on various aspects of ACT-R. The primary role of ACT-R Bookshelf is to serve as a 24-hour information resource for…

43 CFR Appendix F to Part 2 - Mineral Leasing Act and Mineral Leasing Act for Acquired Lands-Special Rules

Code of Federal Regulations, 2012 CFR

2012-10-01

... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Mineral Leasing Act and Mineral Leasing Act...—Mineral Leasing Act and Mineral Leasing Act for Acquired Lands—Special Rules (a) Definitions. As used in... conduct coal exploration operations on land subject to the Mineral Leasing Act, under 30 U.S.C. 201(b), or...

Deriving depth-dependent light escape efficiency and optical Swank factor from measured pulse height spectra of scintillators.

PubMed

Howansky, Adrian; Peng, Boyu; Lubinsky, Anthony R; Zhao, Wei

2017-03-01

Pulse height spectroscopy has been used by investigators to deduce the imaging properties of scintillators. Pulse height spectra (PHS) are used to compute the Swank factor, which describes the variation in scintillator light output per x-ray interaction. The spread in PHS measured below the K-edge is related to the optical component of the Swank factor, i.e., variations in light escape efficiency from different depths of x-ray interaction in the scintillator, denoted ε¯(z). Optimizing scintillators for medical imaging applications requires understanding of these optical properties, as they determine tradeoffs between parameters such as x-ray absorption, light yield, and spatial resolution. This work develops a model for PHS acquisition such that the effect of measurement uncertainty can be removed. This method allows ε¯(z) to be quantified on an absolute scale and permits more accurate estimation of the optical Swank factor of scintillators. The pulse height spectroscopy acquisition chain was modeled as a linear system of stochastic gain stages. Analytical expressions were derived for signal and noise propagation through the PHS chain, accounting for deterministic and stochastic aspects of x-ray absorption, scintillation, and light detection with a photomultiplier tube. The derived expressions were used to calculate PHS of thallium-doped cesium iodide (CsI) scintillators using parameters that were measured, calculated, or known from literature. PHS were measured at 25 and 32 keV of CsI samples designed with an optically reflective or absorptive backing, with or without a fiber-optic faceplate (FOP), and with thicknesses ranging from 150-1000 μm. Measured PHS were compared with calculated PHS, then light escape model parameters were varied until measured and modeled results reached agreement. Resulting estimates of ε¯(z) were used to calculate each scintillator's optical Swank factor. For scintillators of the same optical design, only minor differences in light escape efficiency were observed between samples with different thickness. As thickness increased, escape efficiency decreased by up to 20% for interactions furthest away from light collection. Optical design (i.e., backing and FOP) predominantly affected the magnitude and relative variation in ε¯(z). Depending on interaction depth and scintillator thickness, samples with an absorptive backing and FOP were estimated to yield 4.1-13.4 photons/keV. Samples with a reflective backing and FOP yielded 10.4-18.4 keV -1 , while those with a reflective backing and no FOP yielded 29.5-52.0 keV -1 . Optical Swank factors were approximately 0.9 and near-unity in samples featuring an absorptive or reflective backing, respectively. This work uses a modeling approach to remove the noise introduced by the measurement apparatus from measured PHS. This method allows absolute quantification of ε¯(z) and more accurate estimation of the optical Swank factor of scintillators. The method was applied to CsI scintillators with different thickness and optical design, and determined that optical design more strongly affects ε¯(z) and Swank factor than differences in CsI thickness. Despite large variations in ε¯(z) between optical designs, the Swank factor of all evaluated samples is above 0.9. Information provided by this methodology can help validate Monte Carlo simulations of structured CsI and optimize scintillator design for x-ray imaging applications. © 2016 American Association of Physicists in Medicine.

Deriving depth-dependent light escape efficiency and optical Swank factor from measured pulse height spectra of scintillators

PubMed Central

Howansky, Adrian; Peng, Boyu; Lubinsky, Anthony R.; Zhao, Wei

2017-01-01

Purpose Pulse height spectroscopy has been used by investigators to deduce the imaging properties of scintillators. Pulse height spectra (PHS) are used to compute the Swank factor, which describes the variation in scintillator light output per x-ray interaction. The spread in PHS measured below the K-edge is related to the optical component of the Swank factor, i.e. variations in light escape efficiency from different depths of x-ray interaction in the scintillator, denoted ε̄(z). Optimizing scintillators for medical imaging applications requires understanding of these optical properties, as they determine tradeoffs between parameters such as x-ray absorption, light yield, and spatial resolution. This work develops a model for PHS acquisition such that the effect of measurement uncertainty can be removed. This method allows ε̄(z) to be quantified on an absolute scale and permits more accurate estimation of the optical Swank factor of scintillators. Methods The pulse height spectroscopy acquisition chain was modeled as a linear system of stochastic gain stages. Analytical expressions were derived for signal and noise propagation through the PHS chain, accounting for deterministic and stochastic aspects of x-ray absorption, scintillation, and light detection with a photomultiplier tube. The derived expressions were used to calculate PHS of thallium-doped cesium iodide (CsI) scintillators using parameters that were measured, calculated, or known from literature. PHS were measured at 25 and 32 keV of CsI samples designed with an optically-reflective or absorptive backing, with or without a fiber-optic faceplate (FOP), and with thicknesses ranging from 150–1000 μm. Measured PHS were compared with calculated PHS, then light escape model parameters were varied until measured and modeled results reached agreement. Resulting estimates of ε̄(z) were used to calculate each scintillator’s optical Swank factor. Results For scintillators of the same optical design, only minor differences in light escape efficiency were observed between samples with different thickness. As thickness increased, escape efficiency decreased by up to 20% for interactions furthest away from light collection. Optical design (i.e. backing and FOP) predominantly affected the magnitude and relative variation in ε̄(z). Depending on interaction depth and scintillator thickness, samples with an absorptive backing and FOP were estimated to yield 4.1–13.4 photons/keV. Samples with a reflective backing and FOP yielded 10.4–18.4 keV−1, while those with a reflective backing and no FOP yielded 29.5–52.0 keV−1. Optical Swank factors were approximately 0.9 and near-unity in samples featuring an absorptive or reflective backing, respectively. Conclusions This work uses a modeling approach to remove the noise introduced by the measurement apparatus from measured PHS. This method allows absolute quantification of ε̄(z) and more accurate estimation of the optical Swank factor of scintillators. The method was applied to CsI scintillators with different thickness and optical design, and determined that optical design more strongly affects ε̄(z) and Swank factor than differences in CsI thickness. Despite large variations in ε̄(z) between optical designs, the Swank factor of all evaluated samples is above 0.9. Information provided by this methodology can help validate Monte Carlo simulations of structured CsI and optimize scintillator design for x-ray imaging applications. PMID:28039881

29 CFR 4.102 - Administration of the Act.

Code of Federal Regulations, 2010 CFR

2010-07-01

...'Hara Service Contract Act Introductory § 4.102 Administration of the Act. As provided by section 4 of the Act and under provisions of sections 4 and 5 of the Walsh-Healey Public Contracts Act (49 Stat... authorized and directed to administer and enforce the provisions of the McNamara-O'Hara Service Contract Act...

31 CFR 561.312 - Act of international terrorism.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Act of international terrorism. 561... General Definitions § 561.312 Act of international terrorism. The term act of international terrorism has.... 1701 note). As of February 27, 2012, the term act of international terrorism means an act which is...

31 CFR 561.312 - Act of international terrorism.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Act of international terrorism. 561... General Definitions § 561.312 Act of international terrorism. The term act of international terrorism has.... 1701 note). As of February 27, 2012, the term act of international terrorism means an act which is...

31 CFR 561.312 - Act of international terrorism.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Act of international terrorism. 561... General Definitions § 561.312 Act of international terrorism. The term act of international terrorism has.... 1701 note). As of February 27, 2012, the term act of international terrorism means an act which is...

7 CFR 33.1 - Act.

Code of Federal Regulations, 2011 CFR

2011-01-01

... AUTHORITY OF THE EXPORT APPLE ACT Definitions § 33.1 Act. Act and Export Apple Act are synonymous and mean “An act to promote the foreign trade of the United States in apples to protect the reputation of American-grown apples in foreign markets, to prevent deception or misrepresentation as to the quality of...

7 CFR 33.1 - Act.

Code of Federal Regulations, 2010 CFR

2010-01-01

... AUTHORITY OF THE EXPORT APPLE ACT Definitions § 33.1 Act. Act and Export Apple Act are synonymous and mean “An act to promote the foreign trade of the United States in apples to protect the reputation of American-grown apples in foreign markets, to prevent deception or misrepresentation as to the quality of...

7 CFR 33.1 - Act.

Code of Federal Regulations, 2014 CFR

2014-01-01

... AUTHORITY OF THE EXPORT APPLE ACT Definitions § 33.1 Act. Act and Export Apple Act are synonymous and mean “An act to promote the foreign trade of the United States in apples to protect the reputation of American-grown apples in foreign markets, to prevent deception or misrepresentation as to the quality of...

7 CFR 33.1 - Act.

Code of Federal Regulations, 2012 CFR

2012-01-01

... AUTHORITY OF THE EXPORT APPLE ACT Definitions § 33.1 Act. Act and Export Apple Act are synonymous and mean “An act to promote the foreign trade of the United States in apples to protect the reputation of American-grown apples in foreign markets, to prevent deception or misrepresentation as to the quality of...

7 CFR 33.1 - Act.

Code of Federal Regulations, 2013 CFR

2013-01-01

... AUTHORITY OF THE EXPORT APPLE ACT Definitions § 33.1 Act. Act and Export Apple Act are synonymous and mean “An act to promote the foreign trade of the United States in apples to protect the reputation of American-grown apples in foreign markets, to prevent deception or misrepresentation as to the quality of...

13 CFR 107.115 - 1940 Act and 1980 Act Companies.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false 1940 Act and 1980 Act Companies. 107.115 Section 107.115 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS INVESTMENT COMPANIES Qualifying for an SBIC License Organizing An Sbic § 107.115 1940 Act and 1980 Act...

20 CFR 718.1 - Statutory provisions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... SAFETY ACT OF 1969, AS AMENDED STANDARDS FOR DETERMINING COAL MINERS' TOTAL DISABILITY OR DEATH DUE TO... Safety Act of 1969, as amended by the Black Lung Benefits Act of 1972, the Federal Mine Safety and Health Amendments Act of 1977, the Black Lung Benefits Reform Act of 1977, the Black Lung Benefits Revenue Act of...

76 FR 58007 - Privacy Act of 1974; Report of a New System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-19

... Social Security Act (the Act). The system of records will contain personally identifiable information... and Medicaid Innovation, Centers for Medicare & Medicaid Services, 7500 Security Boulevard, Mailstop... Social Security Act (the Act) (42 U.S.C. 1395 et seq.) by adding new section 1899 to the Act to establish...

32 CFR 806b.4 - Privacy Act complaints.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 6 2014-07-01 2014-07-01 false Privacy Act complaints. 806b.4 Section 806b.4 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ADMINISTRATION PRIVACY ACT PROGRAM Overview of the Privacy Act Program § 806b.4 Privacy Act complaints. (a) Process Privacy Act...

32 CFR 806b.4 - Privacy Act complaints.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 6 2013-07-01 2013-07-01 false Privacy Act complaints. 806b.4 Section 806b.4 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ADMINISTRATION PRIVACY ACT PROGRAM Overview of the Privacy Act Program § 806b.4 Privacy Act complaints. (a) Process Privacy Act...

32 CFR 806b.4 - Privacy Act complaints.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 6 2011-07-01 2011-07-01 false Privacy Act complaints. 806b.4 Section 806b.4 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ADMINISTRATION PRIVACY ACT PROGRAM Overview of the Privacy Act Program § 806b.4 Privacy Act complaints. (a) Process Privacy Act...

32 CFR 806b.4 - Privacy Act complaints.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 6 2012-07-01 2012-07-01 false Privacy Act complaints. 806b.4 Section 806b.4 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ADMINISTRATION PRIVACY ACT PROGRAM Overview of the Privacy Act Program § 806b.4 Privacy Act complaints. (a) Process Privacy Act...

10 CFR 9.23 - Requests for records.

Code of Federal Regulations, 2010 CFR

2010-01-01

....S.C. 552(a)(3) to the Freedom of Information Act and Privacy Act Officer by an appropriate method... received until the date it is actually received by the Freedom of Information Act and Privacy Act Officer... the Freedom of Information Act and Privacy Act Officer receives the request. A request does not cover...

76 FR 67763 - Privacy Act of 1974; Privacy Act System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-02

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (11-109)] Privacy Act of 1974; Privacy Act... proposed revisions to an existing Privacy Act system of records. SUMMARY: Pursuant to the provisions of the Privacy Act of 1974 (5 U.S.C. 552a), the National Aeronautics and Space Administration is issuing public...

32 CFR 806b.4 - Privacy Act complaints.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Privacy Act complaints. 806b.4 Section 806b.4 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ADMINISTRATION PRIVACY ACT PROGRAM Overview of the Privacy Act Program § 806b.4 Privacy Act complaints. (a) Process Privacy Act...

Educational Legislation in Colonial Zimbabwe (1899-1979)

ERIC Educational Resources Information Center

Richards, Kimberly; Govere, Ephraim

2003-01-01

This article focuses on a historical series of education acts that impacted on education in Rhodesia. These Acts are the: (1) 1899 Education Ordinance; (2) 1903 Education Ordinance; (3) 1907 Education Ordinance; (4) 1929 Department of Native Development Act; (5) 1930 Compulsory Education Act; (6) 1959 African Education Act; (7) 1973 Education Act;…

76 FR 36027 - James Zadroga 9/11 Health and Compensation Act of 2010

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-21

... and Compensation Act of 2010 AGENCY: Department of Justice. ACTION: Notice of proposed rulemaking... Compensation Act of 2010 (Zadroga Act). Title II of the Zadroga Act reactivates the September 11th Victim... amend the regulations implementing the Fund to reflect the changes made by the Zadroga Act. DATES...

28 CFR 51.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Voting Rights Act of 1965, 79 Stat. 437, as amended by the Civil Rights Act of 1968, 82 Stat. 73, the Voting Rights Act Amendments of 1970, 84 Stat. 314, the District of Columbia Delegate Act, 84 Stat. 853, the Voting Rights Act Amendments of 1975, 89 Stat. 400, the Voting Rights Act Amendments of 1982, 96...

28 CFR 51.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Voting Rights Act of 1965, 79 Stat. 437, as amended by the Civil Rights Act of 1968, 82 Stat. 73, the Voting Rights Act Amendments of 1970, 84 Stat. 314, the District of Columbia Delegate Act, 84 Stat. 853, the Voting Rights Act Amendments of 1975, 89 Stat. 400, and the Voting Rights Act Amendments of 1982...

17 CFR 210.6-02 - Definition of certain terms.

Code of Federal Regulations, 2010 CFR

2010-04-01

... ACT OF 1934, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935, INVESTMENT COMPANY ACT OF 1940, INVESTMENT ADVISERS ACT OF 1940, AND ENERGY POLICY AND CONSERVATION ACT OF 1975 Registered Investment Companies § 210... affiliate means an affiliated person as defined in section 2(a)(3) of the Investment Company Act of 1940...

76 FR 38463 - SAFE Mortgage Licensing Act: Minimum Licensing Standards and Oversight Responsibilities

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-30

... Parts 30 and 3400 SAFE Mortgage Licensing Act: Minimum Licensing Standards and Oversight... No. FR-5271-F-03] RIN 2502-A170 SAFE Mortgage Licensing Act: Minimum Licensing Standards and... pursuant to the Secure and Fair Enforcement Mortgage Licensing Act of 2008 (SAFE Act or Act), to ensure...

75 FR 18841 - Office for Civil Rights; Privacy Act of 1974, Amended System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-13

... Privacy Act of 1974, Federal Information Security Management Act of 2002, Computer Security Act of 1987... 1974, Federal Information Security Management Act of 2002, Computer Security Act of 1987, the Paperwork... Oversight, the Chair of the Senate Committee on Homeland Security and Governmental Affairs, and the...

23 CFR 633.211 - Implementation of the Clean Air Act and the Federal Water Pollution Control Act.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Water Pollution Control Act. 633.211 Section 633.211 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT... Pollution Control Act. Pursuant to regulations of the Environmental Protection Agency (40 CFR part 15) implementing requirements with respect to the Clean Air Act and the Federal Water Pollution Control Act are...

23 CFR 633.211 - Implementation of the Clean Air Act and the Federal Water Pollution Control Act.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Water Pollution Control Act. 633.211 Section 633.211 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT... Pollution Control Act. Pursuant to regulations of the Environmental Protection Agency (40 CFR part 15) implementing requirements with respect to the Clean Air Act and the Federal Water Pollution Control Act are...

23 CFR 633.211 - Implementation of the Clean Air Act and the Federal Water Pollution Control Act.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Water Pollution Control Act. 633.211 Section 633.211 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT... Pollution Control Act. Pursuant to regulations of the Environmental Protection Agency (40 CFR part 15) implementing requirements with respect to the Clean Air Act and the Federal Water Pollution Control Act are...

23 CFR 633.211 - Implementation of the Clean Air Act and the Federal Water Pollution Control Act.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Water Pollution Control Act. 633.211 Section 633.211 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT... Pollution Control Act. Pursuant to regulations of the Environmental Protection Agency (40 CFR part 15) implementing requirements with respect to the Clean Air Act and the Federal Water Pollution Control Act are...

33 CFR 153.417 - Reimbursement for actions under section 311(c) or 311(d) of the Act of the Intervention on the...

Code of Federal Regulations, 2012 CFR

2012-07-01

... section 311(c) or 311(d) of the Act of the Intervention on the High Seas Act. 153.417 Section 153.417... Reimbursement for actions under section 311(c) or 311(d) of the Act of the Intervention on the High Seas Act. (a... 311(d) of the Act or under the Intervention on the High Seas Act must, within 60 days after completion...

33 CFR 153.417 - Reimbursement for actions under section 311(c) or 311(d) of the Act of the Intervention on the...

Code of Federal Regulations, 2014 CFR

2014-07-01

... section 311(c) or 311(d) of the Act of the Intervention on the High Seas Act. 153.417 Section 153.417... Reimbursement for actions under section 311(c) or 311(d) of the Act of the Intervention on the High Seas Act. (a... 311(d) of the Act or under the Intervention on the High Seas Act must, within 60 days after completion...

33 CFR 153.417 - Reimbursement for actions under section 311(c) or 311(d) of the Act of the Intervention on the...

Code of Federal Regulations, 2013 CFR

2013-07-01

... section 311(c) or 311(d) of the Act of the Intervention on the High Seas Act. 153.417 Section 153.417... Reimbursement for actions under section 311(c) or 311(d) of the Act of the Intervention on the High Seas Act. (a... 311(d) of the Act or under the Intervention on the High Seas Act must, within 60 days after completion...

Domestic Security Cooperation: A Unified Approach to Homeland Security and Defense

DTIC Science & Technology

2012-09-01

counter the threats to homeland security that included the Espionage Act of 1917 and the Sedition Act of 1918. National Defense Act of 1916...the threats to homeland security that included the Espionage Act of 1917 and the Sedition Act of 1918. The Espionage Act of 1917 outlawed interfering...years or both.”12 The Sedition Act of 1918 broadened this law by including the U.S. government and prohibited uttering, printing, writing, or

7 CFR 63.1 - Act.

Code of Federal Regulations, 2011 CFR

2011-01-01

... ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) NATIONAL SHEEP INDUSTRY IMPROVEMENT CENTER... Development Act, 7 U.S.C. 2008j, as amended by section 11009 of the Food, Conservation, and Energy Act of 2008...

75 FR 5716 - Federal Acquisition Regulation; FAR Case 2008-024, Inflation Adjustment of Acquisition-Related...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-04

... Consumer Price Index for all urban consumers, except for Davis-Bacon Act, Service Contract Act, and trade... consumers, except for Davis-Bacon Act, Service Contract Act, and trade agreements thresholds (see FAR 1.109... acquisition-related thresholds established by the Davis-Bacon Act, the Service Contract Act, or the United...

48 CFR 37.107 - Service Contract Act of 1965.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Service Contract Act of... Act of 1965. The Service Contract Act of 1965 (41 U.S.C. 351-357) (the Act) provides for minimum wages... subpart 22.10). Whether or not the Act applies to a specific service contract will be determined by the...

ACT Participation and Performance for Montgomery County Public Schools Students [2013]. Memorandum

ERIC Educational Resources Information Center

Sanderson, Geoffrey T.

2013-01-01

The Montgomery County Public Schools (MCPS) Class of 2013 consistently outperformed graduates across Maryland and the nation on all sections of the ACT, according to the ACT, Inc. annual report released Wednesday, August 21, 2013. In 2013, 29 percent of MCPS graduates took the ACT exam. According to the ACT, Inc. report, ACT participation among…

ACT Reporting Category Interpretation Guide: Version 1.0. ACT Working Paper 2016 (05)

ERIC Educational Resources Information Center

Powers, Sonya; Li, Dongmei; Suh, Hongwook; Harris, Deborah J.

2016-01-01

ACT reporting categories and ACT Readiness Ranges are new features added to the ACT score reports starting in fall 2016. For each reporting category, the number correct score, the maximum points possible, the percent correct, and the ACT Readiness Range, along with an indicator of whether the reporting category score falls within the Readiness…

18 CFR 367.1440 - Account 144, Accumulated provision for uncollectible accounts-Credit.

Code of Federal Regulations, 2010 CFR

2010-04-01

... UTILITY HOLDING COMPANY ACT OF 2005, FEDERAL POWER ACT AND NATURAL GAS ACT UNIFORM SYSTEM OF ACCOUNTS FOR CENTRALIZED SERVICE COMPANIES SUBJECT TO THE PROVISIONS OF THE PUBLIC UTILITY HOLDING COMPANY ACT OF 2005, FEDERAL POWER ACT AND NATURAL GAS ACT Balance Sheet Chart of Accounts Current and Accrued Assets § 367...

18 CFR 367.1080 - Account 108, Accumulated provision for depreciation of service company property.

Code of Federal Regulations, 2010 CFR

2010-04-01

... COMPANY ACT OF 2005, FEDERAL POWER ACT AND NATURAL GAS ACT Balance Sheet Chart of Accounts § 367.1080..., Accumulated provision for depreciation of service company property. 367.1080 Section 367.1080 Conservation of... THE PUBLIC UTILITY HOLDING COMPANY ACT OF 2005, FEDERAL POWER ACT AND NATURAL GAS ACT UNIFORM SYSTEM...

75 FR 67301 - Antidisruptive Practices Authority Contained in the Dodd-Frank Wall Street Reform and Consumer...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-02

... Practices Authority Contained in the Dodd-Frank Wall Street Reform and Consumer Protection Act AGENCY.... SUMMARY: The Dodd-Frank Wall Street Reform and Consumer Protection Act (the ``Dodd-Frank Act'') amends... Reform and Consumer Protection Act (``Dodd-Frank Act'').\\2\\ Title VII of the Dodd-Frank Act \\3\\ amended...

29 CFR 24.111 - Withdrawal of complaints, objections, and petitions for review; settlement.

Code of Federal Regulations, 2011 CFR

2011-07-01

... settlement under the Energy Reorganization Act, the Clean Air Act, the Safe Drinking Water Act, or the Toxic... withdrawn because of settlement under the Energy Reorganization Act, the Clean Air Act, the Safe Drinking... AND SECTION 211 OF THE ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Miscellaneous Provisions § 24.111...

29 CFR 24.111 - Withdrawal of complaints, objections, and petitions for review; settlement.

Code of Federal Regulations, 2013 CFR

2013-07-01

... settlement under the Energy Reorganization Act, the Clean Air Act, the Safe Drinking Water Act, or the Toxic... withdrawn because of settlement under the Energy Reorganization Act, the Clean Air Act, the Safe Drinking... AND SECTION 211 OF THE ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Miscellaneous Provisions § 24.111...

29 CFR 24.111 - Withdrawal of complaints, objections, and petitions for review; settlement.

Code of Federal Regulations, 2012 CFR

2012-07-01

... settlement under the Energy Reorganization Act, the Clean Air Act, the Safe Drinking Water Act, or the Toxic... withdrawn because of settlement under the Energy Reorganization Act, the Clean Air Act, the Safe Drinking... AND SECTION 211 OF THE ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Miscellaneous Provisions § 24.111...

29 CFR 24.111 - Withdrawal of complaints, objections, and petitions for review; settlement.

Code of Federal Regulations, 2014 CFR

2014-07-01

... settlement under the Energy Reorganization Act, the Clean Air Act, the Safe Drinking Water Act, or the Toxic... withdrawn because of settlement under the Energy Reorganization Act, the Clean Air Act, the Safe Drinking... AND SECTION 211 OF THE ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Miscellaneous Provisions § 24.111...

43 CFR 2.222 - Records subject to Privacy Act.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Records subject to Privacy Act. 2.222 Section 2.222 Public Lands: Interior Office of the Secretary of the Interior FREEDOM OF INFORMATION ACT; RECORDS AND TESTIMONY Privacy Act § 2.222 Records subject to Privacy Act. The Privacy Act applies to all...

43 CFR 2.47 - Records subject to Privacy Act.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Records subject to Privacy Act. 2.47 Section 2.47 Public Lands: Interior Office of the Secretary of the Interior RECORDS AND TESTIMONY; FREEDOM OF INFORMATION ACT Privacy Act § 2.47 Records subject to Privacy Act. The Privacy Act applies to all...

43 CFR 2.47 - Records subject to Privacy Act.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Records subject to Privacy Act. 2.47 Section 2.47 Public Lands: Interior Office of the Secretary of the Interior RECORDS AND TESTIMONY; FREEDOM OF INFORMATION ACT Privacy Act § 2.47 Records subject to Privacy Act. The Privacy Act applies to all...

43 CFR 2.222 - Records subject to Privacy Act.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Records subject to Privacy Act. 2.222 Section 2.222 Public Lands: Interior Office of the Secretary of the Interior FREEDOM OF INFORMATION ACT; RECORDS AND TESTIMONY Privacy Act § 2.222 Records subject to Privacy Act. The Privacy Act applies to all...

39 CFR 3004.30 - Relationship among the Freedom of Information Act, the Privacy Act, and the Commission's...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Relationship among the Freedom of Information Act... INFORMATION ACT § 3004.30 Relationship among the Freedom of Information Act, the Privacy Act, and the... which may be released under FOIA. (d) Requesting a Postal Service record. The Commission maintains...

43 CFR 2.47 - Records subject to Privacy Act.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Records subject to Privacy Act. 2.47 Section 2.47 Public Lands: Interior Office of the Secretary of the Interior RECORDS AND TESTIMONY; FREEDOM OF INFORMATION ACT Privacy Act § 2.47 Records subject to Privacy Act. The Privacy Act applies to all...

78 FR 14366 - Triangle Capital Corporation; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-05

... SECURITIES AND EXCHANGE COMMISSION [Investment Company Act Release No. 30410; 812-14077] Triangle... Company Act of 1940 (the ``Act'') for exemptions from sections 23(a), 23(b) and 63 of the Act, and under sections 57(a)(4) and 57(i) of the Act and rule 17d-1 under the Act authorizing certain joint transactions...

76 FR 30390 - Notice of Lodging of Settlement Agreement Under the Comprehensive Environmental Response...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-25

... et seq. (``RCRA''), the Clean Water Act (``CWA''), 33 U.S.C. 1251 et seq., and the Oil Pollution Act... Environmental Response, Compensation, and Liability Act; Resource Conservation and Recovery Act; Clean Water Act; Oil Pollution Act; and Chapter 11 of the United States Bankruptcy Code Notice is hereby given that on...

Long-acting reversible contraceptive acceptability and unintended pregnancy among women presenting for short-acting methods: a randomized patient preference trial.

PubMed

Hubacher, David; Spector, Hannah; Monteith, Charles; Chen, Pai-Lien; Hart, Catherine

2017-02-01

Measures of contraceptive effectiveness combine technology and user-related factors. Observational studies show higher effectiveness of long-acting reversible contraception compared with short-acting reversible contraception. Women who choose long-acting reversible contraception may differ in key ways from women who choose short-acting reversible contraception, and it may be these differences that are responsible for the high effectiveness of long-acting reversible contraception. Wider use of long-acting reversible contraception is recommended, but scientific evidence of acceptability and successful use is lacking in a population that typically opts for short-acting methods. The objective of the study was to reduce bias in measuring contraceptive effectiveness and better isolate the independent role that long-acting reversible contraception has in preventing unintended pregnancy relative to short-acting reversible contraception. We conducted a partially randomized patient preference trial and recruited women aged 18-29 years who were seeking a short-acting method (pills or injectable). Participants who agreed to randomization were assigned to 1 of 2 categories: long-acting reversible contraception or short-acting reversible contraception. Women who declined randomization but agreed to follow-up in the observational cohort chose their preferred method. Under randomization, participants chose a specific method in the category and received it for free, whereas participants in the preference cohort paid for the contraception in their usual fashion. Participants were followed up prospectively to measure primary outcomes of method continuation and unintended pregnancy at 12 months. Kaplan-Meier techniques were used to estimate method continuation probabilities. Intent-to-treat principles were applied after method initiation for comparing incidence of unintended pregnancy. We also measured acceptability in terms of level of happiness with the products. Of the 916 participants, 43% chose randomization and 57% chose the preference option. Complete loss to follow-up at 12 months was <2%. The 12-month method continuation probabilities were 63.3% (95% confidence interval, 58.9-67.3) (preference short-acting reversible contraception), 53.0% (95% confidence interval, 45.7-59.8) (randomized short-acting reversible contraception), and 77.8% (95% confidence interval, 71.0-83.2) (randomized long-acting reversible contraception) (P < .001 in the primary comparison involving randomized groups). The 12-month cumulative unintended pregnancy probabilities were 6.4% (95% confidence interval, 4.1-8.7) (preference short-acting reversible contraception), 7.7% (95% confidence interval, 3.3-12.1) (randomized short-acting reversible contraception), and 0.7% (95% confidence interval, 0.0-4.7) (randomized long-acting reversible contraception) (P = .01 when comparing randomized groups). In the secondary comparisons involving only short-acting reversible contraception users, the continuation probability was higher in the preference group compared with the randomized group (P = .04). However, the short-acting reversible contraception randomized group and short-acting reversible contraception preference group had statistically equivalent rates of unintended pregnancy (P = .77). Seventy-eight percent of randomized long-acting reversible contraception users were happy/neutral with their initial method, compared with 89% of randomized short-acting reversible contraception users (P < .05). However, among method continuers at 12 months, all groups were equally happy/neutral (>90%). Even in a typical population of women who presented to initiate or continue short-acting reversible contraception, long-acting reversible contraception proved highly acceptable. One year after initiation, women randomized to long-acting reversible contraception had high continuation rates and consequently experienced superior protection from unintended pregnancy compared with women using short-acting reversible contraception; these findings are attributable to the initial technology and not underlying factors that often bias observational estimates of effectiveness. The similarly patterned experiences of the 2 short-acting reversible contraception cohorts provide a bridge of generalizability between the randomized group and usual-care preference group. Benefits of increased voluntary uptake of long-acting reversible contraception may extend to wider populations than previously thought. Copyright © 2016 Elsevier Inc. All rights reserved.

Active Deformation in the Overriding Plate Associated with Temporal Changes of the Philippine Sea Plate Motion

NASA Astrophysics Data System (ADS)

Ishiyama, T.; Sato, H.; Van Horne, A.

2015-12-01

We present detailed geologic evidence linking changes over time in Philippine Sea plate (PHS) motion and intracontinental deformation in central and southwest (SW) Japan during the Pliocene and after. In the early Pliocene, subduction of the PHS plate under SW Japan restarted in a northerly direction after period of deceleration or cessation. Later, motion changed to a more westerly direction. Corresponding geological changes found in the overriding plate include unconformities in the forearc basins, changes in slip sense on faults, depocenter migration, re-organization of drainage systems and volcanism. Quaternary intraplate deformation is prominent north of the Median Tectonic Line (MTL) inactive segment, above a shallow flat slab. In contrast, less Quaternary tectonic activity is found north of the MTL active segment which lies over a steadily-slipping portion of the subducting slab that behaves as a less-deformed rigid block. Depocenters and active thrusting have migrated north/northwestward over the past 5 My above the shallow flat slab segment of the PHS. We reconstructed the Plio-Pleistocene migration history using Neogene stratigraphy and shallow seismic reflection profiles. We see shallow PHS slab contact with the lower continental crust in our deep seismic reflection profiles, which may explain its enhanced downward drag of the overriding plate and synchronous strong compression in the crust. We find evidence of more westerly PHS plate subduction since the middle Pleistocene in (1) unconformities in the Kumano forearc basin deposits in SW Japan, (2) drastic stream captures in Shikoku, and (3) concordant changes in fault slip sense from thrust to dextral slip along the MTL. Oblique subduction could have induced stronger horizontal stress in the overriding plate above the shallow flat slab which could account for the increasing geologic slip rate observed on active structures. During four repetitions of megathrust earthquake sequences since the 17th century, ca. 65 % of all intraplate M>6.5 earthquakes have been concentrated in the area above the PHS flat slab. This also suggests that mechanical interaction between the slab and the overriding plate plays an important role in intraplate seismicity over shorter timescales as well.

77 FR 33100 - Endangered and Threatened Wildlife and Plants; Technical Correction for African Wild Ass

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-05

... Federal Actions The Endangered Species Preservation Act was passed in 1966 (the 1966 Act) and was limited... wild ass) under the Endangered Species Act of 1973, as amended (Act). We are revising the List of... Endangered Species Act of 1973 (Act), as amended. We are revising the entry for ``Ass, African wild'' under...

76 FR 37979 - Cooperation in USDA Studies and Evaluations, and Full Use of Federal Funds in Nutrition...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-29

... Funds in Nutrition Assistance Programs Nondiscretionary Provisions of the Healthy, Hunger-Free Kids Act... nondiscretionary provisions of the Healthy, Hunger-Free Kids Act of 2010 (HHFK Act). The HHFK Act requires State...: Background The Healthy, Hunger-Free Kids Act of 2010, Public Law 111-296, (the HHFK Act), was signed into law...

75 FR 30411 - Privacy Act of 1974; Report of a Modified or Altered System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-01

... Privacy Act of 1974; the Federal Information Security Management Act of 2002; the Computer Fraud and Abuse... Security Management Act of 2002; the Computer Fraud and Abuse Act of 1986; the Health Insurance Portability... systems and data files necessary for compliance with Title XI, Part C of the Social Security Act because...

32 CFR 806b.11 - When to give Privacy Act Statements (PAS).

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 6 2011-07-01 2011-07-01 false When to give Privacy Act Statements (PAS). 806b... ADMINISTRATION PRIVACY ACT PROGRAM Collecting Personal Information § 806b.11 When to give Privacy Act Statements... information. Give a copy of the Privacy Act Statement if asked. Do not ask the person to sign the Privacy Act...

32 CFR 806b.11 - When to give Privacy Act Statements (PAS).

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 6 2013-07-01 2013-07-01 false When to give Privacy Act Statements (PAS). 806b... ADMINISTRATION PRIVACY ACT PROGRAM Collecting Personal Information § 806b.11 When to give Privacy Act Statements... information. Give a copy of the Privacy Act Statement if asked. Do not ask the person to sign the Privacy Act...

32 CFR 806b.11 - When to give Privacy Act Statements (PAS).

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false When to give Privacy Act Statements (PAS). 806b... ADMINISTRATION PRIVACY ACT PROGRAM Collecting Personal Information § 806b.11 When to give Privacy Act Statements... information. Give a copy of the Privacy Act Statement if asked. Do not ask the person to sign the Privacy Act...

12 CFR 741.214 - Report of crime or catastrophic act and Bank Secrecy Act compliance.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Report of crime or catastrophic act and Bank Secrecy Act compliance. 741.214 Section 741.214 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION... Unions § 741.214 Report of crime or catastrophic act and Bank Secrecy Act compliance. Any credit union...

19 CFR 147.23 - Compliance with Plant Quarantine Act and Federal Food, Drug, and Cosmetic Act.

Code of Federal Regulations, 2010 CFR

2010-04-01

... the plant quarantine regulations. (b) Federal Food, Drug, and Cosmetic Act. The entry of food products... Food, Drug, and Cosmetic Act. 147.23 Section 147.23 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION... Laws § 147.23 Compliance with Plant Quarantine Act and Federal Food, Drug, and Cosmetic Act. (a) Plant...

19 CFR 147.23 - Compliance with Plant Quarantine Act and Federal Food, Drug, and Cosmetic Act.

Code of Federal Regulations, 2011 CFR

2011-04-01

... the plant quarantine regulations. (b) Federal Food, Drug, and Cosmetic Act. The entry of food products... Food, Drug, and Cosmetic Act. 147.23 Section 147.23 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION... Laws § 147.23 Compliance with Plant Quarantine Act and Federal Food, Drug, and Cosmetic Act. (a) Plant...

Child Welfare Act and Child Custody and Right of Access Act. Finland.

ERIC Educational Resources Information Center

Utriainen, Sirpa, Ed.

The two major articles of child welfare legislation in Finland are the Child Welfare Act of 1983 and the Child Custody and Right of Access Act of 1983. These new acts are part of a reform of social legislation and services providing increased flexibility and effectiveness in protecting Finnish children's health and happiness. The Acts attach…

19 CFR 147.23 - Compliance with Plant Quarantine Act and Federal Food, Drug, and Cosmetic Act.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Food, Drug, and Cosmetic Act. 147.23 Section 147.23 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION... Laws § 147.23 Compliance with Plant Quarantine Act and Federal Food, Drug, and Cosmetic Act. (a) Plant... the plant quarantine regulations. (b) Federal Food, Drug, and Cosmetic Act. The entry of food products...

19 CFR 147.23 - Compliance with Plant Quarantine Act and Federal Food, Drug, and Cosmetic Act.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Food, Drug, and Cosmetic Act. 147.23 Section 147.23 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION... Laws § 147.23 Compliance with Plant Quarantine Act and Federal Food, Drug, and Cosmetic Act. (a) Plant... the plant quarantine regulations. (b) Federal Food, Drug, and Cosmetic Act. The entry of food products...

19 CFR 147.23 - Compliance with Plant Quarantine Act and Federal Food, Drug, and Cosmetic Act.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Food, Drug, and Cosmetic Act. 147.23 Section 147.23 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION... Laws § 147.23 Compliance with Plant Quarantine Act and Federal Food, Drug, and Cosmetic Act. (a) Plant... the plant quarantine regulations. (b) Federal Food, Drug, and Cosmetic Act. The entry of food products...

Detection of Acute Myocardial Infarction in a Pig Model Using the SAN-Atrial-AVN-His (SAAH) Electrocardiogram (ECG), Model PHS-A10, an Automated and Integrated Signals Recognition System

PubMed Central

Zhao, Wenjiao; Lu, Guihua; Liu, Li; Sun, Zhishan; Wu, Mingxin; Yi, Wenyan; Chen, Haiyan; Li, Yanhui

2018-01-01

Background The aim of this study was to compare the use of the standard 12-lead electrocardiogram (ECG) with the SAN-Atrial-AVN-His (SAAH) ECG (Model PHS-A10), a new automated and integrated signals recognition system that detects micro-waveforms within the P, QRS, and T-wave, in a pig model of acute myocardial infarction (MI). Material/Methods Six medium-sized domestic Chinese pigs underwent general anesthesia, and an angioplasty balloon was placed and dilated for 120 minutes in the first diagonal coronary artery arising from the left anterior descending (LAD) coronary artery. A standard ECG and a SAAH ECG (Model PHS-A10) were used to evaluate: 1) the number of wavelets in ST-T segment in lead V5; 2) the duration of the repolarization initial (Ri), or duration of the wavelets starting from the J-point to the endpoint of the wavelets in the ST interval; 3) the duration of the repolarization terminal (Rt), of the wavelets, starting from the endpoint of the wavelets in the ST interval to the cross-point of the T-wave and baseline; 4) the ratio Ri: Rt. Results Following coronary artery occlusion, duration of Ri and Ri/Rt increased, and Rt decreased, which was detected by the SAAH ECG (Model PHS-A10) within 12 seconds, compared with standard ECG that detected ST segment depression at 24 seconds following coronary artery occlusion. Conclusions The findings from this preliminary study in a pig model of acute MI support the need for clinical studies to evaluate the SAAH ECG (Model PHS-A10) for the early detection of acute MI. PMID:29502127

Detection of Acute Myocardial Infarction in a Pig Model Using the SAN-Atrial-AVN-His (SAAH) Electrocardiogram (ECG), Model PHS-A10, an Automated and Integrated Signals Recognition System.

PubMed

Zhao, Wenjiao; Lu, Guihua; Liu, Li; Sun, Zhishan; Wu, Mingxin; Yi, Wenyan; Chen, Haiyan; Li, Yanhui; Tang, Lilong; Zeng, Jianping

2018-03-04

BACKGROUND The aim of this study was to compare the use of the standard 12-lead electrocardiogram (ECG) with the SAN-Atrial-AVN-His (SAAH) ECG (Model PHS-A10), a new automated and integrated signals recognition system that detects micro-waveforms within the P, QRS, and T-wave, in a pig model of acute myocardial infarction (MI). MATERIAL AND METHODS Six medium-sized domestic Chinese pigs underwent general anesthesia, and an angioplasty balloon was placed and dilated for 120 minutes in the first diagonal coronary artery arising from the left anterior descending (LAD) coronary artery. A standard ECG and a SAAH ECG (Model PHS-A10) were used to evaluate: 1) the number of wavelets in ST-T segment in lead V5; 2) the duration of the repolarization initial (Ri), or duration of the wavelets starting from the J-point to the endpoint of the wavelets in the ST interval; 3) the duration of the repolarization terminal (Rt), of the wavelets, starting from the endpoint of the wavelets in the ST interval to the cross-point of the T-wave and baseline; 4) the ratio Ri: Rt. RESULTS Following coronary artery occlusion, duration of Ri and Ri/Rt increased, and Rt decreased, which was detected by the SAAH ECG (Model PHS-A10) within 12 seconds, compared with standard ECG that detected ST segment depression at 24 seconds following coronary artery occlusion. CONCLUSIONS The findings from this preliminary study in a pig model of acute MI support the need for clinical studies to evaluate the SAAH ECG (Model PHS-A10) for the early detection of acute MI.

Changes in food insecurity, nutritional status, and physical health status after antiretroviral therapy initiation in rural Uganda.

PubMed

Weiser, Sheri D; Gupta, Reshma; Tsai, Alexander C; Frongillo, Edward A; Grede, Nils; Kumbakumba, Elias; Kawuma, Annet; Hunt, Peter W; Martin, Jeffrey N; Bangsberg, David R

2012-10-01

To investigate whether time on antiretroviral therapy (ART) is associated with improvements in food security and nutritional status, and the extent to which associations are mediated by improved physical health status. The Uganda AIDS Rural Treatment Outcomes study, a prospective cohort of HIV-infected adults newly initiating ART in Mbarara, Uganda. Participants initiating ART underwent quarterly structured interview and blood draws. The primary explanatory variable was time on ART, constructed as a set of binary variables for each 3-month period. Outcomes were food insecurity, nutritional status, and PHS. We fit multiple regression models with cluster-correlated robust estimates of variance to account for within-person dependence of observations over time, and analyses were adjusted for clinical and sociodemographic characteristics. Two hundred twenty-eight ART-naive participants were followed for up to 3 years, and 41% were severely food insecure at baseline. The mean food insecurity score progressively declined (test for linear trend P < 0.0001), beginning with the second quarter (b = -1.6; 95% confidence interval: -2.7 to -0.45) and ending with the final quarter (b = -6.4; 95% confidence interval: -10.3 to -2.5). PHS and nutritional status improved in a linear fashion over study follow-up (P < 0.001). Inclusion of PHS in the regression model attenuated the relationship between ART duration and food security. Among HIV-infected individuals in Uganda, food insecurity decreased and nutritional status and PHS improved over time after initiation of ART. Changes in food insecurity were partially explained by improvements in PHS. These data support early initiation of ART in resource-poor settings before decline in functional status to prevent worsening food insecurity and its detrimental effects on HIV treatment outcomes.

Epidemiology of drowning deaths in the Philippines, 1980 to 2011.

PubMed

Martinez, Rammell Eric; Go, John Juliard; Guevarra, Jonathan

2016-01-01

Drowning kills 372 000 people yearly worldwide and is a serious public health issue in the Philippines. This study aims to determine if the drowning death rates in the Philippine Health Statistics (PHS) reports from 1980 to 2011 were underestimated. A retrospective descriptive study was conducted to describe the trend of deaths caused by drowning in the Philippines from official and unofficial sources in the period 1980 to 2011. Information about deaths related to cataclysmic causes, particularly victims of storms and floods, and maritime accidents in the Philippines during the study period were reviewed and compared with the PHS drowning death data. An average of 2496 deaths per year caused by drowning were recorded in the PHS reports from 1980 to 2011 (range 671-3656). The average death rate was 3.5/100 000 population (range 1.3-4.7). An average of 4196 drowning deaths were recorded from 1980 to 2011 (range 1220 to 8788) when catacylsmic events and maritime accidents were combined with PHS data. The average death rate was 6/100 000 population (range 2.5-14.2). Our results showed that on average there were 1700 more drowning deaths per year when deaths caused by cataclysms and maritime accidents were added to the PHS data. This illustrated that drowning deaths were underestimated in the official surveillance data. Passive surveillance and irregular data management are contributing to underestimation of drowning in the Philippines. Additionally, deaths due to flooding, storms and maritime accidents are not counted as drowning deaths, which further contributes to the underestimation. Surveillance of drowning data can be improved using more precise case definitions and a multisectoral approach.

Association of Mediterranean diet and other health behaviours with barriers to healthy eating and perceived health among British adults of retirement age.

PubMed

Lara, Jose; McCrum, Leigh-Ann; Mathers, John C

2014-11-01

Health behaviours including diet, smoking, alcohol consumption, and physical activity, predict health risks at the population level. We explored health behaviours, barriers to healthy eating and self-rated health among individuals of retirement age. Study design 82 men and 124 women participated in an observational, cross-sectional online survey. Main outcome measures A 14-item Mediterranean diet score (MDPS), perceived barriers to healthy eating (PBHE), self-reported smoking, physical activity habits, and current and prior perceived health status (PHS) were assessed. A health behaviours score (HBS) including smoking, physical activity, body mass index (BMI) and MDPS was created to evaluate associations with PHS. Two-step cluster analysis identified natural groups based on PBHE. Analysis of variance was used to evaluate between group comparisons. PBHE number was associated with BMI (r=0.28, P<0.001), age (r=-0.19; P=0.006), and MDPS (r=-0.31; P<0.001). PHBE cluster analysis produced three clusters. Cluster-1 members (busy lifestyle) were significantly younger (57 years), more overweight (28kg/m(2)), scored lower on MDPS (4.7) and reported more PBHE (7). Cluster-3 members (no characteristic PBHE) were leaner (25kg/m(2)), reported the lowest number of PBHE (2), and scored higher on HBS (2.7) and MDPS (6.2). Those in PHS categories, bad/fair, good, and very good, reported mean HBS of 2.0, 2.4 and 3.0, respectively (P<0.001). Compared with the previous year, no significant associations between PHS and HBS were observed. PBHE clusters were associated with BMI, MDPS and PHS and could be a useful tool to tailor interventions for those of peri-retirement age. Copyright © 2014 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

50 CFR 10.1 - Purpose of regulations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... wildlife: Lacey Act, 18 U.S.C. 42. Lacey Act Amendments of 1981, 16 U.S.C. 3371-3378. Migratory Bird Treaty Act, 16 U.S.C. 703-712. Bald and Golden Eagle Protection Act, 16 U.S.C. 668a-668d. Endangered Species Act of 1973, 16 U.S.C. 1531-1543. Tariff Classification Act of 1962, 19 U.S.C. 1202, [Schedule 1, Part...

50 CFR 10.1 - Purpose of regulations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... wildlife: Lacey Act, 18 U.S.C. 42. Lacey Act Amendments of 1981, 16 U.S.C. 3371-3378. Migratory Bird Treaty Act, 16 U.S.C. 703-712. Bald and Golden Eagle Protection Act, 16 U.S.C. 668a-668d. Endangered Species Act of 1973, 16 U.S.C. 1531-1543. Tariff Classification Act of 1962, 19 U.S.C. 1202, [Schedule 1, Part...

50 CFR 10.1 - Purpose of regulations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... wildlife: Lacey Act, 18 U.S.C. 42. Lacey Act Amendments of 1981, 16 U.S.C. 3371-3378. Migratory Bird Treaty Act, 16 U.S.C. 703-712. Bald and Golden Eagle Protection Act, 16 U.S.C. 668a-668d. Endangered Species Act of 1973, 16 U.S.C. 1531-1543. Tariff Classification Act of 1962, 19 U.S.C. 1202, [Schedule 1, Part...

50 CFR 10.1 - Purpose of regulations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... wildlife: Lacey Act, 18 U.S.C. 42. Lacey Act Amendments of 1981, 16 U.S.C. 3371-3378. Migratory Bird Treaty Act, 16 U.S.C. 703-712. Bald and Golden Eagle Protection Act, 16 U.S.C. 668a-668d. Endangered Species Act of 1973, 16 U.S.C. 1531-1543. Tariff Classification Act of 1962, 19 U.S.C. 1202, [Schedule 1, Part...

50 CFR 10.1 - Purpose of regulations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... wildlife: Lacey Act, 18 U.S.C. 42. Lacey Act Amendments of 1981, 16 U.S.C. 3371-3378. Migratory Bird Treaty Act, 16 U.S.C. 703-712. Bald and Golden Eagle Protection Act, 16 U.S.C. 668a-668d. Endangered Species Act of 1973, 16 U.S.C. 1531-1543. Tariff Classification Act of 1962, 19 U.S.C. 1202, [Schedule 1, Part...

78 FR 1251 - Notice of Lodging of Proposed Consent Decree Under the Clean Air Act, the Clean Water Act and the...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-08

... DEPARTMENT OF JUSTICE Notice of Lodging of Proposed Consent Decree Under the Clean Air Act, the Clean Water Act and the Resource Conservation and Recovery Act On December 31, 2012, the Department of....C. 7401 et seq.; the Clean Water Act, 33 U.S.C. 1301 et seq.; and the Resource Conservation and...

18 CFR 382.202 - Annual charges under the Natural Gas Act and Natural Gas Policy Act of 1978 and related statutes.

Code of Federal Regulations, 2010 CFR

2010-04-01

... the Natural Gas Act and Natural Gas Policy Act of 1978 and related statutes. 382.202 Section 382.202... GENERAL RULES ANNUAL CHARGES Annual Charges § 382.202 Annual charges under the Natural Gas Act and Natural Gas Policy Act of 1978 and related statutes. The adjusted costs of administration of the natural gas...

Energy Regulation Effects on Critical Infrastructure Protection

DTIC Science & Technology

2008-12-01

Holding Company Act (1935) PURPA Public Utility Regulatory Policies Act (1978) QF Qualifying Facility RTO Regional Transmission Organization SEC...1935 (PUHCA) and the Federal Power Act; the Public Utility Regulatory Policies Act of 1978 ( PURPA ); and the Energy Policy Acts of 1992 (EPAct 1992) and...Congress passed the Public Utility Regulatory Policies Act ( PURPA ) in 1978 which required electric utilities to buy electricity from other generating

18 CFR 382.202 - Annual charges under the Natural Gas Act and Natural Gas Policy Act of 1978 and related statutes.

Code of Federal Regulations, 2011 CFR

2011-04-01

... the Natural Gas Act and Natural Gas Policy Act of 1978 and related statutes. 382.202 Section 382.202... GENERAL RULES ANNUAL CHARGES Annual Charges § 382.202 Annual charges under the Natural Gas Act and Natural Gas Policy Act of 1978 and related statutes. The adjusted costs of administration of the natural gas...

43 CFR Appendix B to Part 2 - Mineral Leasing Act and Mineral Leasing Act for Acquired Lands-Special Rules

Code of Federal Regulations, 2013 CFR

2013-10-01

... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Mineral Leasing Act and Mineral Leasing... 2—Mineral Leasing Act and Mineral Leasing Act for Acquired Lands—Special Rules (a) Definitions. As... conduct coal exploration operations on land subject to the Mineral Leasing Act, under 30 U.S.C. 201(b), or...

43 CFR Appendix B to Part 2 - Mineral Leasing Act and Mineral Leasing Act for Acquired Lands-Special Rules

Code of Federal Regulations, 2014 CFR

2014-10-01

... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Mineral Leasing Act and Mineral Leasing... 2—Mineral Leasing Act and Mineral Leasing Act for Acquired Lands—Special Rules (a) Definitions. As... conduct coal exploration operations on land subject to the Mineral Leasing Act, under 30 U.S.C. 201(b), or...

43 CFR Appendix F to Part 2 - Mineral Leasing Act and Mineral Leasing Act for Acquired Lands-Special Rules

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Mineral Leasing Act and Mineral Leasing... 2—Mineral Leasing Act and Mineral Leasing Act for Acquired Lands—Special Rules (a) Definitions. As... conduct coal exploration operations on land subject to the Mineral Leasing Act, under 30 U.S.C. 201(b), or...

43 CFR Appendix F to Part 2 - Mineral Leasing Act and Mineral Leasing Act for Acquired Lands-Special Rules

Code of Federal Regulations, 2010 CFR

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Mineral Leasing Act and Mineral Leasing... 2—Mineral Leasing Act and Mineral Leasing Act for Acquired Lands—Special Rules (a) Definitions. As... conduct coal exploration operations on land subject to the Mineral Leasing Act, under 30 U.S.C. 201(b), or...

20 CFR 667.105 - What award document authorizes the expenditure of Workforce Investment Act funds under title I of...

Code of Federal Regulations, 2010 CFR

2010-04-01

... expenditure of Workforce Investment Act funds under title I of the Act? 667.105 Section 667.105 Employees... I OF THE WORKFORCE INVESTMENT ACT Funding § 667.105 What award document authorizes the expenditure of Workforce Investment Act funds under title I of the Act? (a) Agreement. All WIA title I funds that...

20 CFR 667.105 - What award document authorizes the expenditure of Workforce Investment Act funds under title I of...

Code of Federal Regulations, 2011 CFR

2011-04-01

... expenditure of Workforce Investment Act funds under title I of the Act? 667.105 Section 667.105 Employees... I OF THE WORKFORCE INVESTMENT ACT Funding § 667.105 What award document authorizes the expenditure of Workforce Investment Act funds under title I of the Act? (a) Agreement. All WIA title I funds that...

Influence of a fluoridated medium with different pHs on commercially pure titanium-based implants.

PubMed

Sartori, Rafael; Correa, Cassia Bellotto; Marcantonio, Elcio; Vaz, Luis Geraldo

2009-02-01

The objective of this study was to assess the influence of a fluoride medium with different pHs on the corrosion resistance of three commercially pure titanium-based dental implant commercial brands, under scanning electron microscopy (SEM) and EDS. Forty-two dental implants, from three commercial brands, were used. Five years of regular use of mouth rinsing, with NaF 1500 ppm content and two different pHs, were simulated by immersing the specimens into that medium for 184 hours. SEM and EDS analyses demonstrated no evidence of corrosion on the specimens' surfaces after being submitted to fluoride ions or incorporation of fluoride ions to the set surface. It was possible to conclude that both the fluoride concentration and the pH of the solutions did not exert any influence upon implant corrosion resistance.

75 FR 26773 - Public Readiness and Emergency Preparedness Act Countermeasures Injury Compensation Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-12

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Health Resources and Services Administration Public Readiness and Emergency Preparedness Act Countermeasures Injury Compensation Program, Procedures for... and Emergency Preparedness Act (PREP Act). The PREP Act provides compensation to individuals for...

A Citizen's Guide on Using the Freedom of Information Act and the Privacy Act of 1974 To Request Government Records. First Report by the Committee on Government Reform and Oversight. House of Representatives, 104th Congress, 1st Session.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. House Committee on Government Reform and Oversight.

This report explains how to use the Freedom of Information Act (FOIA) and the Privacy Act of 1974. It reflects all changes to the laws made since 1977: major amendments to the Freedom of Information Act passed in 1974 and 1986; a major addition to the Privacy Act of 1974 was enacted in 1988; and minor amendments to the Privacy Act were made in…

Harmful situations, impure people: an attribution asymmetry across moral domains.

PubMed

Chakroff, Alek; Young, Liane

2015-03-01

People make inferences about the actions of others, assessing whether an act is best explained by person-based versus situation-based accounts. Here we examine people's explanations for norm violations in different domains: harmful acts (e.g., assault) and impure acts (e.g., incest). Across four studies, we find evidence for an attribution asymmetry: people endorse more person-based attributions for impure versus harmful acts. This attribution asymmetry is partly explained by the abnormality of impure versus harmful acts, but not by differences in the moral wrongness or the statistical frequency of these acts. Finally, this asymmetry persists even when the situational factors that lead an agent to act impurely are stipulated. These results suggest that, relative to harmful acts, impure acts are linked to person-based attributions. Copyright © 2014 Elsevier B.V. All rights reserved.

South African labour law and HIV / AIDS.

PubMed

Smart, R; Strode, A

1999-01-01

This article contains five key pieces of labor legislation in South Africa, including one applying specifically to the mining industry which protect the rights of employees. These laws include: the Employment Equity Act, No. 55 of 1998; the Labour Relations Act, No. 66 of 1995; the Occupational Health and Safety Act, No. 85 of 1993; the Compensation for Occupational Injuries and Diseases Act No. 130 of 1993; the Mines Health and Safety Act, No. 29 of 1996; and the Basic Conditions of Employment Act, No. 75 of 1997. This paper further presents the Medical Schemes Act, No. 131 of 1998 and the protection of the right to privacy and dignity. Although HIV/AIDS was expressly referred to only in the Employment Equity Act, there are provisions in all the other Acts, which have relevance to HIV/AIDS.

75 FR 6434 - Procedures for Monitoring Secrecy Act Compliance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-09

... Act commonly known as the `Bank Secrecy Act' (``BSA''). The Money Laundering Control Act of 1986... Deposit Insurance Act, which applies to savings associations. Specifically, Section 1359 of the Anti-Drug... examine savings association procedures periodically to ensure their effectiveness; OTS is therefore...

75 FR 20298 - Privacy Act Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-19

... Part 200 RIN 0430-AA03 Privacy Act Regulations AGENCY: Recovery Accountability and Transparency Board... amend the Board's regulations implementing the Privacy Act of 1974 (Privacy Act), as amended. This proposed rule would exempt certain systems of records from certain sections of the Privacy Act. These...

78 FR 10249 - Notice of Final Federal Agency Actions on Proposed Highway in California

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-13

.... Clean Water Act of 1977 and 1987. 7. Federal Water Pollution Control Act of 1972 (see Clean Water Act of 1977 & 1987). 8. Noise Control Act of 1972. 9. Safe Drinking Water Act of 1944, as amended. 10...

Sphingosine-1-phosphate stimulates rat primary chondrocyte proliferation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Mi-Kyoung; Lee, Ha Young; Kwak, Jong-Young

2006-06-23

Rat primary chondrocytes express the sphingosine-1-phosphate (S1P) receptor, S1P{sub 2}, S1P{sub 3}, S1P{sub 4}, but not S1P{sub 1}. When chondrocytes were stimulated with S1P or phytosphingosine-1-phosphate (PhS1P, an S1P{sub 1}- and S1P{sub 4}-selective agonist), phospholipase C-mediated cytosolic calcium increase was dramatically induced. S1P and PhS1P also stimulated two kinds of mitogen-activated protein kinases, extracellular signal-regulated kinase (ERK) and p38 kinase in chondrocytes. In terms of the two phospholipids-mediated functional modulation of chondrocytes, S1P and PhS1P stimulated cellular proliferation. The two phospholipids-induced chondrocyte proliferations were almost completely blocked by PD98059 but not by SB203580, suggesting that ERK but not p38 kinasemore » is essentially required for the proliferation. Pertussis toxin almost completely inhibited the two phospholipids-induced cellular proliferation and ERK activation, indicating the crucial role of G{sub i} protein. This study demonstrates the physiological role of two important phospholipids (S1P and PhS1P) on the modulation of rat primary chondrocyte proliferation, and the crucial role played by ERK in the process.« less

Reprogramming of Seed Metabolism Facilitates Pre-harvest Sprouting Resistance of Wheat.

PubMed

Liu, Caixiang; Ding, Feng; Hao, Fuhua; Yu, Men; Lei, Hehua; Wu, Xiangyu; Zhao, Zhengxi; Guo, Hongxiang; Yin, Jun; Wang, Yulan; Tang, Huiru

2016-02-10

Pre-harvest sprouting (PHS) is a worldwide problem for wheat production and transgene antisense-thioredoxin-s (anti-trx-s) facilitates outstanding resistance. To understand the molecular details of PHS resistance, we analyzed the metabonomes of the transgenic and wild-type (control) wheat seeds at various stages using NMR and GC-FID/MS. 60 metabolites were dominant in these seeds including sugars, organic acids, amino acids, choline metabolites and fatty acids. At day-20 post-anthesis, only malate level in transgenic wheat differed significantly from that in controls whereas at day-30 post-anthesis, levels of amino acids and sucrose were significantly different between these two groups. For mature seeds, most metabolites in glycolysis, TCA cycle, choline metabolism, biosynthesis of proteins, nucleotides and fatty acids had significantly lower levels in transgenic seeds than in controls. After 30-days post-harvest ripening, most metabolites in transgenic seeds had higher levels than in controls including amino acids, sugars, organic acids, fatty acids, choline metabolites and NAD(+). These indicated that anti-trx-s lowered overall metabolic activities of mature seeds eliminating pre-harvest sprouting potential. Post-harvest ripening reactivated the metabolic activities of transgenic seeds to restore their germination vigor. These findings provided essential molecular phenomic information for PHS resistance of anti-trx-s and a credible strategy for future developing PHS resistant crops.

Metrics associated with NIH funding: a high-level view.

PubMed

Boyack, Kevin W; Jordan, Paul

2011-01-01

To introduce the availability of grant-to-article linkage data associated with National Institutes of Health (NIH) grants and to perform a high-level analysis of the publication outputs and impacts associated with those grants. Articles were linked to the grants they acknowledge using the grant acknowledgment strings in PubMed using a parsing and matching process as embodied in the NIH Scientific Publication Information Retrieval & Evaluation System system. Additional data from PubMed and citation counts from Scopus were added to the linkage data. The data comprise 2,572,576 records from 1980 to 2009. The data show that synergies between NIH institutes are increasing over time; 29% of current articles acknowledge grants from multiple institutes. The median time lag to publication for a new grant is 3 years. Each grant contributes to approximately 1.7 articles per year, averaged over all grant types. Articles acknowledging US Public Health Service (PHS, which includes NIH) funding are cited twice as much as US-authored articles acknowledging no funding source. Articles acknowledging both PHS funding and a non-US government funding source receive on average 40% more citations that those acknowledging PHS funding sources alone. The US PHS is effective at funding research with a higher-than-average impact. The data are amenable to further and much more detailed analysis.

Perceived health status and cardiometabolic risk among a sample of youth in Mexico

PubMed Central

Flores, Yvonne N.; Shaibi, Gabriel Q.; Morales, Leo S.; Salmerón, Jorge; Skalicky, Anne M.; Edwards, Todd C.; Gallegos-Carrillo, Katia; Patrick, Donald L.

2015-01-01

Purpose To examine differences in self-reported perceived mental and physical health status (PHS), as well as known cardiometabolic risk factors in a sample of normal weight, overweight, and obese Mexican youths. Methods Cross-sectional analysis of 164 youths aged 11-18 years recruited in Cuernavaca, Mexico. Participants completed a self-administered questionnaire that included measures of generic and weight-specific quality of life (QoL), perceived health, physical function, depressive symptoms, and body shape satisfaction. Height, weight and waist circumference were measured and body mass index (BMI) was determined. Fasting blood samples from participants yielded levels of glucose, triglycerides, and cholesterol (total, HDL and LDL). Results Nearly 50% of participants were female, 21% had a normal BMI, 39% were overweight, and 40% were obese. Obese youths reported significantly lower measures of PHS and showed an increase in cardiometabolic risk, compared to normal weight youths. Physical functioning, generic and weight-specific QoL were inversely associated with BMI, waist circumference and glucose. Depressive symptoms were positively correlated with BMI, waist circumference, glucose levels and HDL cholesterol. No correlation was found between PHS and cardiometabolic risk measures after controlling for BMI. Conclusions In this sample of Mexican youths, obesity was associated with a significantly lower PHS and increased cardiometabolic risk. PMID:25648756

Reprogramming of Seed Metabolism Facilitates Pre-harvest Sprouting Resistance of Wheat

NASA Astrophysics Data System (ADS)

Liu, Caixiang; Ding, Feng; Hao, Fuhua; Yu, Men; Lei, Hehua; Wu, Xiangyu; Zhao, Zhengxi; Guo, Hongxiang; Yin, Jun; Wang, Yulan; Tang, Huiru

2016-02-01

Pre-harvest sprouting (PHS) is a worldwide problem for wheat production and transgene antisense-thioredoxin-s (anti-trx-s) facilitates outstanding resistance. To understand the molecular details of PHS resistance, we analyzed the metabonomes of the transgenic and wild-type (control) wheat seeds at various stages using NMR and GC-FID/MS. 60 metabolites were dominant in these seeds including sugars, organic acids, amino acids, choline metabolites and fatty acids. At day-20 post-anthesis, only malate level in transgenic wheat differed significantly from that in controls whereas at day-30 post-anthesis, levels of amino acids and sucrose were significantly different between these two groups. For mature seeds, most metabolites in glycolysis, TCA cycle, choline metabolism, biosynthesis of proteins, nucleotides and fatty acids had significantly lower levels in transgenic seeds than in controls. After 30-days post-harvest ripening, most metabolites in transgenic seeds had higher levels than in controls including amino acids, sugars, organic acids, fatty acids, choline metabolites and NAD+. These indicated that anti-trx-s lowered overall metabolic activities of mature seeds eliminating pre-harvest sprouting potential. Post-harvest ripening reactivated the metabolic activities of transgenic seeds to restore their germination vigor. These findings provided essential molecular phenomic information for PHS resistance of anti-trx-s and a credible strategy for future developing PHS resistant crops.

The Labour Welfare Fund Laws (Amendment) Act, 1987 (No. 15 of 1987), 22 May 1987.

PubMed

1987-01-01

This Act authorizes funds constituted under the Mica Mines Labour Welfare Fund Act, 1946, the Limestone and Dolomite Mines Labour Welfare Fund Act, 1972, the Iron Ore Mines, Manganese Ore Mines and Chrome Mines Labour Welfare Fund Act, 1976, and the Beedi Workers Welfare Fund Act, 1976, to be applied for the provision of family welfare, including family planning education and services. full text

18 CFR 35.29 - Treatment of special assessments levied under the Atomic Energy Act of 1954, as amended by Title...

Code of Federal Regulations, 2011 CFR

2011-04-01

... assessments levied under the Atomic Energy Act of 1954, as amended by Title XI of the Energy Policy Act of... Other Filing Requirements § 35.29 Treatment of special assessments levied under the Atomic Energy Act of... relating to special assessments under the Atomic Energy Act of 1954, as amended by the Energy Policy Act of...

18 CFR 35.29 - Treatment of special assessments levied under the Atomic Energy Act of 1954, as amended by Title...

Code of Federal Regulations, 2012 CFR

2012-04-01

... assessments levied under the Atomic Energy Act of 1954, as amended by Title XI of the Energy Policy Act of... Other Filing Requirements § 35.29 Treatment of special assessments levied under the Atomic Energy Act of... relating to special assessments under the Atomic Energy Act of 1954, as amended by the Energy Policy Act of...

18 CFR 35.29 - Treatment of special assessments levied under the Atomic Energy Act of 1954, as amended by Title...

Code of Federal Regulations, 2010 CFR

2010-04-01

... assessments levied under the Atomic Energy Act of 1954, as amended by Title XI of the Energy Policy Act of... Other Filing Requirements § 35.29 Treatment of special assessments levied under the Atomic Energy Act of... relating to special assessments under the Atomic Energy Act of 1954, as amended by the Energy Policy Act of...

18 CFR 35.29 - Treatment of special assessments levied under the Atomic Energy Act of 1954, as amended by Title...

Code of Federal Regulations, 2013 CFR

2013-04-01

... assessments levied under the Atomic Energy Act of 1954, as amended by Title XI of the Energy Policy Act of... Other Filing Requirements § 35.29 Treatment of special assessments levied under the Atomic Energy Act of... relating to special assessments under the Atomic Energy Act of 1954, as amended by the Energy Policy Act of...

18 CFR 35.29 - Treatment of special assessments levied under the Atomic Energy Act of 1954, as amended by Title...

Code of Federal Regulations, 2014 CFR

2014-04-01

... assessments levied under the Atomic Energy Act of 1954, as amended by Title XI of the Energy Policy Act of... Other Filing Requirements § 35.29 Treatment of special assessments levied under the Atomic Energy Act of... relating to special assessments under the Atomic Energy Act of 1954, as amended by the Energy Policy Act of...

Recovery Act Education Programs: Funding Retained Teachers, but Education Could More Consistently Communicate Stabilization Monitoring Issues. Report to Congress. GAO-11-804

ERIC Educational Resources Information Center

Scott, George A.

2011-01-01

The American Recovery and Reinvestment Act of 2009 (Recovery Act) provided $70.3 billion for three education programs--the State Fiscal Stabilization Fund (SFSF); Title I, Part A of the Elementary and Secondary Education Act (Title I); and Individuals with Disabilities Education Act (IDEA), Part B. One goal of the Recovery Act was to save and…

42 CFR 417.159 - Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act...

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 3 2014-10-01 2014-10-01 false Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act and the Railway Labor Act. 417.159 Section 417.159 Public... § 417.159 Relationship of section 1310 of the Public Health Service Act to the National Labor Relations...

42 CFR 417.159 - Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act...

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 3 2012-10-01 2012-10-01 false Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act and the Railway Labor Act. 417.159 Section 417.159 Public... § 417.159 Relationship of section 1310 of the Public Health Service Act to the National Labor Relations...

42 CFR 417.159 - Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act...

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 3 2013-10-01 2013-10-01 false Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act and the Railway Labor Act. 417.159 Section 417.159 Public... § 417.159 Relationship of section 1310 of the Public Health Service Act to the National Labor Relations...

75 FR 41278 - Notice of Final Federal Agency Actions on Proposed Highway in Idaho

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-15

...]; Fish and Wildlife Coordination Act [16 U.S.C. 661-667(d)]; Migratory Bird Treaty Act [16 U.S.C. 703-712... Preservation Act of 1974 [16 U.S.C. 469-469(c)]. Land: Section 4(f) of The Department of Transportation Act: [23 CFR 774]; Farmland Protection Policy Act (FPPA) [7 U.S.C. 4201-4209]; Solid Waste Disposal Act, as...

Anticancer property of sediment actinomycetes against MCF-7 and MDA-MB-231 cell lines.

PubMed

Ravikumar, S; Fredimoses, M; Gnanadesigan, M

2012-02-01

To investigate the anticancer property of marine sediment actinomycetes against two different breast cancer cell lines. In vitro anticancer activity was carried out against breast (MCF-7 and MDA-MB-231) cancer cell lines. Partial sequences of the 16s rRNA gene, phylogenetic tree construction, multiple sequence analysis and secondary structure analysis were also carried out with the actinomycetes isolates. Of the selected five actinomycete isolates, ACT01 and ACT02 showed the IC50 value with (10.13±0.92) and (22.34±5.82) µg/mL concentrations, respectively for MCF-7 cell line at 48 h, but ACT01 showed the minimum (18.54±2.49 µg/mL) level of IC50 value with MDA-MB-231 cell line. Further, the 16s rRNA partial sequences of ACT01, ACT02, ACT03, ACT04 and ACT05 isolates were also deposited in NCBI data bank with the accession numbers of GQ478246, GQ478247, GQ478248, GQ478249 and GQ478250, respectively. The phylogenetic tree analysis showed that, the isolates of ACT02 and ACT03 were represented in group I and III, respectively, but ACT01 and ACT02 were represented in group II. The multiple sequence alignment of the actinomycete isolates showed that, the maximum identical conserved regions were identified with the nucleotide regions of 125 to 221st base pairs, 65 to 119th base pairs and 55, 48 and 31st base pairs. Secondary structure prediction of the 16s rRNA showed that, the maximum free energy was consumed with ACT03 isolate (-45.4 kkal/mol) and the minimum free energy was consumed with ACT04 isolate (-57.6 kkal/mol). The actinomycete isolates of ACT01 and ACT02 (GQ478246 and GQ478247) which are isolated from sediment sample can be further used as anticancer agents against breast cancer cell lines.

43 CFR 10005.11 - Environmental compliance.

Code of Federal Regulations, 2013 CFR

2013-10-01

...) the Fish and Wildlife Coordination Act, the National Environmental Policy Act of 1969 (NEPA), and the Endangered Species Act of 1973.” While not specifically referenced in that section, the Federal Water Pollution Control Act (Clean Water Act) (33 U.S.C. 1251 et seq.) also contains environmental compliance...

43 CFR 10005.11 - Environmental compliance.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) the Fish and Wildlife Coordination Act, the National Environmental Policy Act of 1969 (NEPA), and the Endangered Species Act of 1973.” While not specifically referenced in that section, the Federal Water Pollution Control Act (Clean Water Act) (33 U.S.C. 1251 et seq.) also contains environmental compliance...

43 CFR 10005.11 - Environmental compliance.

Code of Federal Regulations, 2012 CFR

2012-10-01

...) the Fish and Wildlife Coordination Act, the National Environmental Policy Act of 1969 (NEPA), and the Endangered Species Act of 1973.” While not specifically referenced in that section, the Federal Water Pollution Control Act (Clean Water Act) (33 U.S.C. 1251 et seq.) also contains environmental compliance...

43 CFR 10005.11 - Environmental compliance.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) the Fish and Wildlife Coordination Act, the National Environmental Policy Act of 1969 (NEPA), and the Endangered Species Act of 1973.” While not specifically referenced in that section, the Federal Water Pollution Control Act (Clean Water Act) (33 U.S.C. 1251 et seq.) also contains environmental compliance...

75 FR 51917 - Perishable Agricultural Commodities Act: Increase in License Fees

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-24

... of the proposed license fee increase. Paperwork Reduction Act In accordance with Office of Management... 0581-AC92 Perishable Agricultural Commodities Act: Increase in License Fees AGENCY: Agricultural... regulations issued under the Perishable Agricultural Commodities Act (PACA or Act) to increase license fees...

7 CFR 1260.128 - Act.

Code of Federal Regulations, 2010 CFR

2010-01-01

... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BEEF PROMOTION AND RESEARCH Beef Promotion and Research Order Definitions § 1260.128 Act. Act means the Beef Promotion and Research Act of 1985, Title XVI, Subtitle A of the Food Security Act of 1985, Pub. L. 99-198 and any amendments thereto. ...

75 FR 1373 - Beaches Environmental Assessment and Coastal Health Act

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-11

... Health Act AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of Availability of 2010 BEACH... Environmental Assessment and Coastal Health (BEACH) Act authorizes EPA to award program development and...? The Beaches Environmental Assessment and Coastal Health (BEACH) Act of 2000 amends the Clean Water Act...

75 FR 82382 - Beaches Environmental Assessment and Coastal Health Act

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-30

... Health Act AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of Availability of 2011 BEACH... Environmental Assessment and Coastal Health (BEACH) Act authorizes EPA to award program development and... the BEACH Act? The Beaches Environmental Assessment and Coastal Health (BEACH) Act of 2000 amends the...

77 FR 5793 - Beaches Environmental Assessment and Coastal Health Act; Availability of BEACH Act Grants

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-06

... ENVIRONMENTAL PROTECTION AGENCY [OW-FRL-9627-4] Beaches Environmental Assessment and Coastal Health Act; Availability of BEACH Act Grants AGENCY: Environmental Protection Agency (EPA). ACTION... Environmental Assessment and Coastal Health (BEACH) Act authorizes EPA to award program development and...

43 CFR 429.2 - What definitions are used in this part?

Code of Federal Regulations, 2011 CFR

2011-10-01

... the requirements of the National Environmental Policy Act; the Endangered Species Act; the Clean Water Act; the Clean Air Act; the Comprehensive Environmental Response, Compensation, and Liability Act... term includes, but is not limited to, buildings, canals, dams, ditches, drains, fish and wildlife...

Privacy Act

EPA Pesticide Factsheets

Learn about the Privacy Act of 1974, the Electronic Government Act of 2002, the Federal Information Security Management Act, and other information about the Environmental Protection Agency maintains its records.

48 CFR 52.222-20 - Walsh-Healey Public Contracts Act.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Contracts Act. 52.222-20 Section 52.222-20 Federal Acquisition Regulations System FEDERAL ACQUISITION... Clauses 52.222-20 Walsh-Healey Public Contracts Act. As prescribed in 22.610, insert the following clause in solicitations and contracts covered by the Act: Walsh-Healey Public Contracts Act (OCT 2010) If...

75 FR 3187 - Defense Federal Acquisition Regulation Supplement: Inflation Adjustment of Acquisition-Related...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-20

... Davis-Bacon Act, Service Contract Act, and trade agreements thresholds. This case also reviews... Contract Act, and trade agreements thresholds. This case also reviews nonstatutory DFARS acquisition... Davis Bacon Act, the Service Contract Act, or trade agreements. The statute does not authorize DoD to...

48 CFR 22.1003-2 - Geographical coverage of the Act.

Code of Federal Regulations, 2010 CFR

2010-10-01

... REGULATION SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Service Contract Act of 1965, as Amended 22.1003-2 Geographical coverage of the Act. The Act applies to service contracts performed in the United States (see 22.1001). The Act does not apply to contracts performed outside the...

31 CFR 3.20 - General.

Code of Federal Regulations, 2010 CFR

2010-07-01

... owned property caused by the negligence of any officer or employee of the Government acting within the scope of his employment. The Federal Tort Claims Act superseded the Small Claims Act with respect to... Federal Tort Claims Act, for example, claims arising abroad, may be allowable under the Small Claims Act. ...

7 CFR 35.1 - Act.

Code of Federal Regulations, 2011 CFR

2011-01-01

...), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS EXPORT GRAPES AND PLUMS Definitions § 35.1 Act. Act or Export Grape and Plum Act means “An Act to promote the foreign trade of the United States in grapes and plums, to protect the reputation of American-grown grapes and plums in...

17 CFR 210.12-13 - Investments other than securities.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Investments other than... EXCHANGE ACT OF 1934, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935, INVESTMENT COMPANY ACT OF 1940, INVESTMENT ADVISERS ACT OF 1940, AND ENERGY POLICY AND CONSERVATION ACT OF 1975 Form and Content of Schedules...

76 FR 64114 - Privacy Act of 1974; Privacy Act System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-17

....C. 2473 (2003); Federal Records Act, 44 U.S.C. 3101 (2003); Chief Financial Officers Act of 1990 205.... ADDRESSES: Patti F. Stockman, Privacy Act Officer, Office of the Chief Information Officer, National... Information Officer. NASA 10CFMR SYSTEM NAME: Core Financial Management Records. SECURITY CLASSIFICATION: This...

31 CFR 50.5 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... and Finance: Treasury Office of the Secretary of the Treasury TERRORISM RISK INSURANCE PROGRAM General Provisions § 50.5 Definitions. For purposes of this Part: (a) Act means the Terrorism Risk Insurance Act of 2002. (b) Act of terrorism—(1) In general. The term act of terrorism means any act that is certified by...

31 CFR 50.5 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... and Finance: Treasury Office of the Secretary of the Treasury TERRORISM RISK INSURANCE PROGRAM General Provisions § 50.5 Definitions. For purposes of this Part: (a) Act means the Terrorism Risk Insurance Act of 2002. (b) Act of terrorism—(1) In general. The term act of terrorism means any act that is certified by...

31 CFR 50.5 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... and Finance: Treasury Office of the Secretary of the Treasury TERRORISM RISK INSURANCE PROGRAM General Provisions § 50.5 Definitions. For purposes of this Part: (a) Act means the Terrorism Risk Insurance Act of 2002. (b) Act of terrorism—(1) In general. The term act of terrorism means any act that is certified by...

31 CFR 50.5 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... and Finance: Treasury Office of the Secretary of the Treasury TERRORISM RISK INSURANCE PROGRAM General Provisions § 50.5 Definitions. For purposes of this Part: (a) Act means the Terrorism Risk Insurance Act of 2002. (b) Act of terrorism—(1) In general. The term act of terrorism means any act that is certified by...

48 CFR 22.403-4 - Department of Labor regulations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... under the Davis-Bacon Act, Contract Work Hours and Safety Standards Act, Copeland (Anti-Kickback) Act... Division, or administrative law judges under the Davis-Bacon Act, Contract Work Hours and Safety Standards... of weekly payroll records; (3) Part 5, relating to enforcement of the Davis-Bacon Act, Contract Work...

43 CFR 2611.1-5 - Priority of Carey Act applications.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Priority of Carey Act applications. 2611.1... LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) CAREY ACT GRANTS Segregation Under the Carey Act: Procedures § 2611.1-5 Priority of Carey Act applications. Properly filed...

17 CFR 210.12-13 - Investments other than securities.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Investments other than... EXCHANGE ACT OF 1934, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935, INVESTMENT COMPANY ACT OF 1940, INVESTMENT ADVISERS ACT OF 1940, AND ENERGY POLICY AND CONSERVATION ACT OF 1975 Form and Content of Schedules...

The Winners' Circle

ERIC Educational Resources Information Center

Reese, Susan

2007-01-01

In this article, the author presents the ACTE's award winning educators for 2007. They are: (1) Leslie Watkins, 2007 ACTE Teacher of the Year; (2) Mike Gillispie, 2007 ACTE Outstanding Career and Technical Educator; (3) Sandy Hume, 2007 ACTE Outstanding New Career and Technical Teacher; and (4) Joline Dunbar, 2007 ACTE Outstanding Teacher in…

18 CFR 367.1430 - Account 143, Other accounts receivable.

Code of Federal Regulations, 2010 CFR

2010-04-01

... REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE PUBLIC UTILITY HOLDING COMPANY ACT OF 2005, FEDERAL POWER ACT AND NATURAL GAS ACT UNIFORM SYSTEM OF ACCOUNTS FOR CENTRALIZED SERVICE COMPANIES SUBJECT TO THE PROVISIONS OF THE PUBLIC UTILITY HOLDING COMPANY ACT OF 2005, FEDERAL POWER ACT AND NATURAL...

ACHP | Advisory Council on Historic Preservation

Science.gov Websites

Search Recovery Act skip specific nav links Home arrow Recovery Act Recovery Act Recovery Act Economics creation, community revitalization, and sustainable development. Click here to read about Economics and information on Indian Country Works. Recovery Act | Economics | Section 106 Q&A | Tool Kit | Recovery

5 CFR 1302.2 - Requests for access.

Code of Federal Regulations, 2011 CFR

2011-01-01

....2 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET ADMINISTRATIVE PROCEDURES PRIVACY ACT... the Privacy Act of 1974. In the absence of specifying solely the Privacy Act of 1974 and, if the request may be processed under both the Freedom of Information Act and the Privacy Act and the request...

The Environmental Education Act of 1970: Success or Failure?

ERIC Educational Resources Information Center

Marcus, Melvin G.

1984-01-01

Identifies and interprets several problems that beset environmental education (EE) and the Office of Environmental Education (OEE). Areas addressed include Public Law 91-516 (Environmental Education Act) and the OEE, problems related to implementing the act, funding, misinterpretation of the act's intent, the act's identity, and the status of EE…

18 CFR 367.24 - Construction and service contracts for other companies.

Code of Federal Regulations, 2010 CFR

2010-04-01

... service company undertakes projects to construct physical property for associate or non-associate... COMPANY ACT OF 2005, FEDERAL POWER ACT AND NATURAL GAS ACT UNIFORM SYSTEM OF ACCOUNTS FOR CENTRALIZED... POWER ACT AND NATURAL GAS ACT General Instructions § 367.24 Construction and service contracts for other...

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17 CFR 210.6A-03 - Statements of financial condition.

Code of Federal Regulations, 2010 CFR

2010-04-01

... EXCHANGE ACT OF 1934, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935, INVESTMENT COMPANY ACT OF 1940, INVESTMENT ADVISERS ACT OF 1940, AND ENERGY POLICY AND CONSERVATION ACT OF 1975 Employee Stock Purchase... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Statements of financial...

18 CFR 367.3960 - Account 396, Power operated equipment.

Code of Federal Regulations, 2010 CFR

2010-04-01

... REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE PUBLIC UTILITY HOLDING COMPANY ACT OF 2005, FEDERAL POWER ACT AND NATURAL GAS ACT UNIFORM SYSTEM OF ACCOUNTS FOR CENTRALIZED SERVICE COMPANIES SUBJECT TO THE PROVISIONS OF THE PUBLIC UTILITY HOLDING COMPANY ACT OF 2005, FEDERAL POWER ACT AND NATURAL...

18 CFR 367.1240 - Account 124, Other investments.

Code of Federal Regulations, 2010 CFR

2010-04-01

... COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE PUBLIC UTILITY HOLDING COMPANY ACT OF 2005, FEDERAL POWER ACT AND NATURAL GAS ACT UNIFORM SYSTEM OF ACCOUNTS FOR CENTRALIZED SERVICE COMPANIES SUBJECT TO THE PROVISIONS OF THE PUBLIC UTILITY HOLDING COMPANY ACT OF 2005, FEDERAL POWER ACT AND NATURAL GAS...

18 CFR 367.54 - Expenditures on leased property.

Code of Federal Regulations, 2010 CFR

2010-04-01

... COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE PUBLIC UTILITY HOLDING COMPANY ACT OF 2005, FEDERAL POWER ACT AND NATURAL GAS ACT UNIFORM SYSTEM OF ACCOUNTS FOR CENTRALIZED SERVICE COMPANIES SUBJECT TO THE PROVISIONS OF THE PUBLIC UTILITY HOLDING COMPANY ACT OF 2005, FEDERAL POWER ACT AND NATURAL GAS...

45 CFR 670.9 - Antarctic Conservation Act enforcement exception.

Code of Federal Regulations, 2011 CFR

2011-10-01

... FOUNDATION CONSERVATION OF ANTARCTIC ANIMALS AND PLANTS Prohibited Acts, Exceptions § 670.9 Antarctic Conservation Act enforcement exception. Paragraphs (a) through (d) of § 670.4 shall not apply to acts carried... 45 Public Welfare 3 2011-10-01 2011-10-01 false Antarctic Conservation Act enforcement exception...

45 CFR 670.9 - Antarctic Conservation Act enforcement exception.

Code of Federal Regulations, 2014 CFR

2014-10-01

... FOUNDATION CONSERVATION OF ANTARCTIC ANIMALS AND PLANTS Prohibited Acts, Exceptions § 670.9 Antarctic Conservation Act enforcement exception. Paragraphs (a) through (d) of § 670.4 shall not apply to acts carried... 45 Public Welfare 3 2014-10-01 2014-10-01 false Antarctic Conservation Act enforcement exception...

45 CFR 670.9 - Antarctic Conservation Act enforcement exception.

Code of Federal Regulations, 2010 CFR

2010-10-01

... FOUNDATION CONSERVATION OF ANTARCTIC ANIMALS AND PLANTS Prohibited Acts, Exceptions § 670.9 Antarctic Conservation Act enforcement exception. Paragraphs (a) through (d) of § 670.4 shall not apply to acts carried... 45 Public Welfare 3 2010-10-01 2010-10-01 false Antarctic Conservation Act enforcement exception...

45 CFR 670.9 - Antarctic Conservation Act enforcement exception.

Code of Federal Regulations, 2012 CFR

2012-10-01

... FOUNDATION CONSERVATION OF ANTARCTIC ANIMALS AND PLANTS Prohibited Acts, Exceptions § 670.9 Antarctic Conservation Act enforcement exception. Paragraphs (a) through (d) of § 670.4 shall not apply to acts carried... 45 Public Welfare 3 2012-10-01 2012-10-01 false Antarctic Conservation Act enforcement exception...

77 FR 38834 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-29

... Conservation Act of 1978 AGENCY: National Science Foundation. ACTION: Notice of permit applications received under the Antarctic Conservation Act of 1978. SUMMARY: The National Science Foundation (NSF) is required... Antarctic Conservation Act of 1978. NSF has published regulations under the Antarctic Conservation Act. This...

45 CFR 670.9 - Antarctic Conservation Act enforcement exception.

Code of Federal Regulations, 2013 CFR

2013-10-01

... FOUNDATION CONSERVATION OF ANTARCTIC ANIMALS AND PLANTS Prohibited Acts, Exceptions § 670.9 Antarctic Conservation Act enforcement exception. Paragraphs (a) through (d) of § 670.4 shall not apply to acts carried... 45 Public Welfare 3 2013-10-01 2013-10-01 false Antarctic Conservation Act enforcement exception...

75 FR 30025 - Privacy Act System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-28

... FEDERAL COMMUNICATIONS COMMISSION Privacy Act System of Records AGENCY: Federal Communications Commission (FCC or Commission). ACTION: Notice; one altered Privacy Act system of records; revision of one... Act of 1974, as amended (``Privacy Act''), 5 U.S.C. 552a, the FCC proposes to alter one system of...

45 CFR 88.5 - Written certification of compliance.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Developmental Disabilities Assistance and Bill of Rights Act of 2000, require such individual to perform or... Health Centers Act, or the Developmental Disabilities Assistance and Bill of Rights Act of 2000 that is... Act, or the Developmental Disabilities Assistance and Bill of Rights Act of 2000, require such...

32 CFR 1701.4 - Privacy Act responsibilities/policy.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 6 2011-07-01 2011-07-01 false Privacy Act responsibilities/policy. 1701.4... NATIONAL INTELLIGENCE ADMINISTRATION OF RECORDS UNDER THE PRIVACY ACT OF 1974 Protection of Privacy and Access to Individual Records Under the Privacy Act of 1974 § 1701.4 Privacy Act responsibilities/policy...

32 CFR 505.12 - Privacy Act enforcement actions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 3 2013-07-01 2013-07-01 false Privacy Act enforcement actions. 505.12 Section... AUTHORITIES AND PUBLIC RELATIONS ARMY PRIVACY ACT PROGRAM § 505.12 Privacy Act enforcement actions. (a.... (1) Civil remedies. The DA is subject to civil remedies for violations of the Privacy Act. In...

32 CFR 1701.4 - Privacy Act responsibilities/policy.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 6 2013-07-01 2013-07-01 false Privacy Act responsibilities/policy. 1701.4... NATIONAL INTELLIGENCE ADMINISTRATION OF RECORDS UNDER THE PRIVACY ACT OF 1974 Protection of Privacy and Access to Individual Records Under the Privacy Act of 1974 § 1701.4 Privacy Act responsibilities/policy...

45 CFR 503.1 - Definitions-Privacy Act.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 3 2013-10-01 2013-10-01 false Definitions-Privacy Act. 503.1 Section 503.1... THE UNITED STATES, DEPARTMENT OF JUSTICE RULES OF PRACTICE PRIVACY ACT AND GOVERNMENT IN THE SUNSHINE REGULATIONS Privacy Act Regulations § 503.1 Definitions—Privacy Act. For the purpose of this part: Agency...

45 CFR 503.1 - Definitions-Privacy Act.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 3 2014-10-01 2014-10-01 false Definitions-Privacy Act. 503.1 Section 503.1... THE UNITED STATES, DEPARTMENT OF JUSTICE RULES OF PRACTICE PRIVACY ACT AND GOVERNMENT IN THE SUNSHINE REGULATIONS Privacy Act Regulations § 503.1 Definitions—Privacy Act. For the purpose of this part: Agency...

32 CFR 1701.4 - Privacy Act responsibilities/policy.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 6 2012-07-01 2012-07-01 false Privacy Act responsibilities/policy. 1701.4... NATIONAL INTELLIGENCE ADMINISTRATION OF RECORDS UNDER THE PRIVACY ACT OF 1974 Protection of Privacy and Access to Individual Records Under the Privacy Act of 1974 § 1701.4 Privacy Act responsibilities/policy...

4 CFR 200.4 - Privacy Act inquiries.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 4 Accounts 1 2013-01-01 2013-01-01 false Privacy Act inquiries. 200.4 Section 200.4 Accounts RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD PRIVACY ACT OF 1974 § 200.4 Privacy Act inquiries. (a... Avenue, NW., Suite 700, Washington, DC 20006. Inquiries should be marked “Privacy Act Inquiry” on each...

45 CFR 503.1 - Definitions-Privacy Act.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 3 2012-10-01 2012-10-01 false Definitions-Privacy Act. 503.1 Section 503.1... THE UNITED STATES, DEPARTMENT OF JUSTICE RULES OF PRACTICE PRIVACY ACT AND GOVERNMENT IN THE SUNSHINE REGULATIONS Privacy Act Regulations § 503.1 Definitions—Privacy Act. For the purpose of this part: Agency...

32 CFR 505.12 - Privacy Act enforcement actions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 3 2014-07-01 2014-07-01 false Privacy Act enforcement actions. 505.12 Section... AUTHORITIES AND PUBLIC RELATIONS ARMY PRIVACY ACT PROGRAM § 505.12 Privacy Act enforcement actions. (a.... (1) Civil remedies. The DA is subject to civil remedies for violations of the Privacy Act. In...

48 CFR 1452.224-1 - Privacy Act Notification.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Privacy Act Notification... Privacy Act Notification. (a) As prescribed in 1424.104, the clause at FAR 52.224-1, Privacy Act... the clause to read “Privacy Act Notification (JUL 1996) (Deviation)”; and (2) Adding the following...

32 CFR 505.12 - Privacy Act enforcement actions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 3 2012-07-01 2009-07-01 true Privacy Act enforcement actions. 505.12 Section... AUTHORITIES AND PUBLIC RELATIONS ARMY PRIVACY ACT PROGRAM § 505.12 Privacy Act enforcement actions. (a.... (1) Civil remedies. The DA is subject to civil remedies for violations of the Privacy Act. In...

4 CFR 200.4 - Privacy Act inquiries.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 4 Accounts 1 2014-01-01 2013-01-01 true Privacy Act inquiries. 200.4 Section 200.4 Accounts RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD PRIVACY ACT OF 1974 § 200.4 Privacy Act inquiries. (a... Avenue, NW., Suite 700, Washington, DC 20006. Inquiries should be marked “Privacy Act Inquiry” on each...

6 CFR 1002.4 - Responses to Privacy Act requests.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 6 Domestic Security 1 2014-01-01 2014-01-01 false Responses to Privacy Act requests. 1002.4 Section 1002.4 Domestic Security PRIVACY AND CIVIL LIBERTIES OVERSIGHT BOARD IMPLEMENTATION OF THE PRIVACY ACT OF 1974 § 1002.4 Responses to Privacy Act requests. (a) Acknowledgement. The Privacy Act Officer...

32 CFR 1701.4 - Privacy Act responsibilities/policy.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 6 2014-07-01 2014-07-01 false Privacy Act responsibilities/policy. 1701.4... NATIONAL INTELLIGENCE ADMINISTRATION OF RECORDS UNDER THE PRIVACY ACT OF 1974 Protection of Privacy and Access to Individual Records Under the Privacy Act of 1974 § 1701.4 Privacy Act responsibilities/policy...

48 CFR 1452.224-1 - Privacy Act Notification.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Privacy Act Notification... Privacy Act Notification. (a) As prescribed in 1424.104, the clause at FAR 52.224-1, Privacy Act... the clause to read “Privacy Act Notification (JUL 1996) (Deviation)”; and (2) Adding the following...

45 CFR 503.1 - Definitions-Privacy Act.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 3 2011-10-01 2011-10-01 false Definitions-Privacy Act. 503.1 Section 503.1... THE UNITED STATES, DEPARTMENT OF JUSTICE RULES OF PRACTICE PRIVACY ACT AND GOVERNMENT IN THE SUNSHINE REGULATIONS Privacy Act Regulations § 503.1 Definitions—Privacy Act. For the purpose of this part: Agency...

48 CFR 1452.224-1 - Privacy Act Notification.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Privacy Act Notification... Privacy Act Notification. (a) As prescribed in 1424.104, the clause at FAR 52.224-1, Privacy Act... the clause to read “Privacy Act Notification (JUL 1996) (Deviation)”; and (2) Adding the following...

4 CFR 200.4 - Privacy Act inquiries.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 4 Accounts 1 2012-01-01 2012-01-01 false Privacy Act inquiries. 200.4 Section 200.4 Accounts RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD PRIVACY ACT OF 1974 § 200.4 Privacy Act inquiries. (a... Avenue, NW., Suite 700, Washington, DC 20006. Inquiries should be marked “Privacy Act Inquiry” on each...

32 CFR 505.12 - Privacy Act enforcement actions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 3 2011-07-01 2009-07-01 true Privacy Act enforcement actions. 505.12 Section... AUTHORITIES AND PUBLIC RELATIONS ARMY PRIVACY ACT PROGRAM § 505.12 Privacy Act enforcement actions. (a.... (1) Civil remedies. The DA is subject to civil remedies for violations of the Privacy Act. In...

4 CFR 200.4 - Privacy Act inquiries.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 4 Accounts 1 2011-01-01 2011-01-01 false Privacy Act inquiries. 200.4 Section 200.4 Accounts RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD PRIVACY ACT OF 1974 § 200.4 Privacy Act inquiries. (a... Avenue, NW., Suite 700, Washington, DC 20006. Inquiries should be marked “Privacy Act Inquiry” on each...

48 CFR 1452.224-1 - Privacy Act Notification.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Privacy Act Notification... Privacy Act Notification. (a) As prescribed in 1424.104, the clause at FAR 52.224-1, Privacy Act... the clause to read “Privacy Act Notification (JUL 1996) (Deviation)”; and (2) Adding the following...

32 CFR 1701.4 - Privacy Act responsibilities/policy.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Privacy Act responsibilities/policy. 1701.4... NATIONAL INTELLIGENCE ADMINISTRATION OF RECORDS UNDER THE PRIVACY ACT OF 1974 Protection of Privacy and Access to Individual Records Under the Privacy Act of 1974 § 1701.4 Privacy Act responsibilities/policy...

75 FR 81454 - Privacy Act of 1974; Implementation

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-28

... JOINT BOARD FOR ENROLLMENT OF ACTUARIES 20 CFR Part 903 Privacy Act of 1974; Implementation AGENCY... requirements of the Privacy Act of 1974, as amended, the Joint Board for the Enrollment of Actuaries (Joint... Privacy Act, from certain of the Privacy Act's provisions, to revise language that incorrectly implies...

45 CFR 503.1 - Definitions-Privacy Act.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Definitions-Privacy Act. 503.1 Section 503.1... THE UNITED STATES, DEPARTMENT OF JUSTICE RULES OF PRACTICE PRIVACY ACT AND GOVERNMENT IN THE SUNSHINE REGULATIONS Privacy Act Regulations § 503.1 Definitions—Privacy Act. For the purpose of this part: Agency...

4 CFR 200.4 - Privacy Act inquiries.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 4 Accounts 1 2010-01-01 2010-01-01 false Privacy Act inquiries. 200.4 Section 200.4 Accounts RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD PRIVACY ACT OF 1974 § 200.4 Privacy Act inquiries. (a... Avenue, NW., Suite 700, Washington, DC 20006. Inquiries should be marked “Privacy Act Inquiry” on each...

48 CFR 1452.224-1 - Privacy Act Notification.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Privacy Act Notification... Privacy Act Notification. (a) As prescribed in 1424.104, the clause at FAR 52.224-1, Privacy Act... the clause to read “Privacy Act Notification (JUL 1996) (Deviation)”; and (2) Adding the following...

77 FR 2721 - Privacy Act System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-19

... FEDERAL COMMUNICATIONS COMMISSION Privacy Act System of Records AGENCY: Federal Communications Commission (FCC, Commission, or Agency). ACTION: Notice; one new Privacy Act system of records. SUMMARY: Pursuant to subsection (e)(4) of the Privacy Act of 1974, as amended (``Privacy Act''), 5 U.S.C. 552a, the...

28 CFR 55.1 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Administration DEPARTMENT OF JUSTICE (CONTINUED) IMPLEMENTATION OF THE PROVISIONS OF THE VOTING RIGHTS ACT... the Voting Rights Act of 1965, 79 Stat. 437, as amended by the Civil Rights Act of 1968, 82 Stat. 73, the Voting Rights Act Amendments of 1970, 84 Stat. 314, the District of Columbia Delegate Act, 84 Stat...

28 CFR 55.1 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Administration DEPARTMENT OF JUSTICE (CONTINUED) IMPLEMENTATION OF THE PROVISIONS OF THE VOTING RIGHTS ACT... the Voting Rights Act of 1965, 79 Stat. 437, as amended by the Civil Rights Act of 1968, 82 Stat. 73, the Voting Rights Act Amendments of 1970, 84 Stat. 314, the District of Columbia Delegate Act, 84 Stat...

75 FR 18500 - Guidance on Improving EPA Review of Appalachian Surface Coal Mining Operations under the Clean...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-12

... of Appalachian Surface Coal Mining Operations under the Clean Water Act, National Environmental... Appalachian Surface Coal Mining Operations under the Clean Water Act, National Environmental Policy Act, and... coal mining operations under the Clean Water Act, National Environmental Policy Act, and the...

The Library Systems Act and Rules for Administering the Library Systems Act.

ERIC Educational Resources Information Center

Texas State Library, Austin. Library Development Div.

This document contains the Texas Library Systems Act and rules for administering the Library Systems Act. Specifically, it includes the following documents: Texas Library Systems Act; Summary of Codes;Texas Administrative Code: Service Complaints and Protest Procedure; Criteria For Texas Library System Membership; and Certification Requirements…

20 CFR 606.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

...' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR TAX CREDITS UNDER THE FEDERAL UNEMPLOYMENT TAX ACT; ADVANCES UNDER TITLE XII OF THE SOCIAL SECURITY ACT General § 606.3 Definitions. For the purposes of the Acts cited and this part— (a) Act means as appropriate the Federal Unemployment Tax Act (26...

42 CFR 137.290 - What additional provisions of law are related to NEPA and NHPA?

Code of Federal Regulations, 2012 CFR

2012-10-01

...) Archeological Resources Protection Act [16 U.S.C. 470aa]; (3) Clean Air Act [42 U.S.C. 7401]; (4) Clean Water Act [33 U.S.C. 1251]; (5) Coastal Barrier Improvement Act [42 U.S.C. 4028 and 16 U.S.C. Sec. 3501]; (6) Coastal Barrier Resources Act [16 U.S.C. 3501]; (7) Coastal Zone Management Act [16 U.S.C. 1451]; (8...

42 CFR 137.290 - What additional provisions of law are related to NEPA and NHPA?

Code of Federal Regulations, 2010 CFR

2010-10-01

...) Archeological Resources Protection Act [16 U.S.C. 470aa]; (3) Clean Air Act [42 U.S.C. 7401]; (4) Clean Water Act [33 U.S.C. 1251]; (5) Coastal Barrier Improvement Act [42 U.S.C. 4028 and 16 U.S.C. Sec. 3501]; (6) Coastal Barrier Resources Act [16 U.S.C. 3501]; (7) Coastal Zone Management Act [16 U.S.C. 1451]; (8...

42 CFR 137.290 - What additional provisions of law are related to NEPA and NHPA?

Code of Federal Regulations, 2013 CFR

2013-10-01

...) Archeological Resources Protection Act [16 U.S.C. 470aa]; (3) Clean Air Act [42 U.S.C. 7401]; (4) Clean Water Act [33 U.S.C. 1251]; (5) Coastal Barrier Improvement Act [42 U.S.C. 4028 and 16 U.S.C. Sec. 3501]; (6) Coastal Barrier Resources Act [16 U.S.C. 3501]; (7) Coastal Zone Management Act [16 U.S.C. 1451]; (8...

42 CFR 137.290 - What additional provisions of law are related to NEPA and NHPA?

Code of Federal Regulations, 2011 CFR

2011-10-01

...) Archeological Resources Protection Act [16 U.S.C. 470aa]; (3) Clean Air Act [42 U.S.C. 7401]; (4) Clean Water Act [33 U.S.C. 1251]; (5) Coastal Barrier Improvement Act [42 U.S.C. 4028 and 16 U.S.C. Sec. 3501]; (6) Coastal Barrier Resources Act [16 U.S.C. 3501]; (7) Coastal Zone Management Act [16 U.S.C. 1451]; (8...

42 CFR 137.290 - What additional provisions of law are related to NEPA and NHPA?

Code of Federal Regulations, 2014 CFR

2014-10-01

...) Archeological Resources Protection Act [16 U.S.C. 470aa]; (3) Clean Air Act [42 U.S.C. 7401]; (4) Clean Water Act [33 U.S.C. 1251]; (5) Coastal Barrier Improvement Act [42 U.S.C. 4028 and 16 U.S.C. Sec. 3501]; (6) Coastal Barrier Resources Act [16 U.S.C. 3501]; (7) Coastal Zone Management Act [16 U.S.C. 1451]; (8...

Recovery Act: States Could Provide More Information on Education Programs to Enhance the Public's Understanding of Fund Use. Report to the Republican Leader, U.S. Senate. GAO-10-807

ERIC Educational Resources Information Center

Ashby, Cornelia M.

2010-01-01

The American Recovery and Reinvestment Act of 2009 (Recovery Act) provides $70.3 billion for three education programs--the State Fiscal Stabilization Fund (SFSF), Title I of the Elementary and Secondary Education Act (Title I), and Individuals with Disabilities Education Act (IDEA). The Act requires recipients to be accountable for how these funds…

29 CFR 1620.27 - Relationship to the Equal Pay Act of title VII of the Civil Rights Act.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 4 2010-07-01 2010-07-01 false Relationship to the Equal Pay Act of title VII of the Civil... OPPORTUNITY COMMISSION THE EQUAL PAY ACT § 1620.27 Relationship to the Equal Pay Act of title VII of the Civil... equal pay under the Equal Pay Act has no relationship to whether the employee is in the lower paying job...

Public Law 94-103: 94th Congress, H.R. 4005, October 4, 1975. An Act to Amend the Developmental Disabilities Services and Facilities Construction Act to Revise and Extend the Programs Authorized by that Act.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Senate.

Presented is the 1975 amendment to the Developmental Disabilities Services and Facilities Construction Act. Described are revisions and extensions of the earlier act, including revision of grant and construction assistance for university affiliated facilities, and revision of special projects assistance. The earlier act's designation of rights of…

The Occupational Disease Prevention and Control Act of the People's Republic of China: an awareness assessment among workers at foreign-invested enterprises.

PubMed

Yongming, Shou; Rongzhu, Lu; Jie, Lin; Yan, Xu; Zhu, Yiliang; Schweigert, Michael

2011-01-01

The Occupational Disease Prevention and Control Act (ODPC-Act) of the People's Republic of China came into effect on May 1, 2002. Given the scope of foreign-invested enterprises (FIEs) in China and an unabated increasing trend of foreign investment, compliance with the ODPC-Act among FIEs is of particular interest, yet little is known. The extent to which an employer educates its workforce to understand the ODPC-Act may be a measure of an employer's compliance. Based on a 25-item questionnaire survey, we found that among 166 workers from three FIEs in Wuxi, Jiangsu Province, the majority had little knowledge regarding the ODPC-Act; many were unaware of their rights granted under the ODPC-Act. They were also unable to recognize employers' potential violations of the ODPC-Act. Improving FIE workers' awareness of the ODPC-Act is desirable.

Post-transcriptional regulation of α-1-antichymotrypsin by microRNA-137 in chronic heart failure and mechanical support.

PubMed

Lok, Sjoukje I; van Mil, Alain; Bovenschen, Niels; van der Weide, Petra; van Kuik, Joyce; van Wichen, Dick; Peeters, Ton; Siera, Erica; Winkens, Bjorn; Sluijter, Joost P G; Doevendans, Pieter A; da Costa Martins, Paula A; de Jonge, Nicolaas; de Weger, Roel A

2013-07-01

Better understanding of the molecular mechanisms of remodeling has become a major objective of heart failure (HF) research to stop or reverse its progression. Left ventricular assist devices (LVADs) are being used in patients with HF, leading to partial reverse remodeling. In the present study, proteomics identified significant changes in α-1-antichymotrypsin (ACT) levels during LVAD support. Moreover, the potential role of ACT in reverse remodeling was studied in detail. Expression of ACT mRNA (quantitative-polymerase chain reaction) decreased significantly in post-LVAD myocardial tissue compared with pre-LVAD tissue (n=15; P<0.01). Immunohistochemistry revealed that ACT expression and localization changed during LVAD support. Circulating ACT levels were elevated in HF patients (n=18) as compared with healthy controls (n=6; P=0.001) and normalized by 6 months of LVAD support. Because increasing evidence implicates that microRNAs (miRs) are involved in myocardial disease processes, we also investigated whether ACT is post-transcriptionally regulated by miRs. Bioinformatics analysis pointed miR-137 as a potential regulator of ACT. The miR-137 expression is inversely correlated with ACT mRNA in myocardial tissue. Luciferase activity assays confirmed ACT as a direct target for miR-137, and in situ hybridization indicated that ACT and miR-137 were mainly localized in cardiomyocytes and stromal cells. High ACT plasma levels in HF normalized during LVAD support, which coincides with decreased ACT mRNA in heart tissue, whereas miR-137 levels increased. MiR-137 directly targeted ACT, thereby indicating that ACT and miR-137 play a role in the pathophysiology of HF and reverse remodeling during mechanical support.

The Administration of the Institutions of Higher Education Act. (Act No. 362 of June 13, 1973, as Amended in Pursuance of Act No. 328 of June 10, 1976).

ERIC Educational Resources Information Center

Ministry of Education, Copenhagen (Denmark).

An English-language transcript of the Administration of the Institutions of Higher Education Act of Denmark (Act No. 362 of June 13, 1973 as amended in pursuance of Act No. 328 of June 10, 1976) is provided. General provisions lay out the responsibilities of the Ministry of Education in regard to higher education institutions. Responsibilities of…

Improving the Timeliness of Equal Employment Opportunity Complaint Processing in Department of Defense

DTIC Science & Technology

2015-01-01

1964 (Title VII) and the Pregnancy Discrimination Act amendment to Title VII, the Equal Pay Act of 1963, the Age Discrimi- nation in Employment Act of...Act of 1964 (Title VII) and the Pregnancy Discrimination Act amendment to Title VII, the Equal Pay Act of 1963, the Age Discrimination in...EEO programs uti - lize training on the EEO complaint process and framing of claims and that they use more-structured investigation requests

Alpha-1-antichymotrypsin (ACT or SERPINA3) polymorphism may affect age-at-onset and disease duration of Alzheimer's disease.

PubMed

Kamboh, M Ilyas; Minster, Ryan L; Kenney, Margaret; Ozturk, Ayla; Desai, Purnima P; Kammerer, Candace M; DeKosky, Steven T

2006-10-01

In addition to genetic effects on disease risk, age-at-onset (AAO) of Alzheimer's disease (AD) is also genetically controlled. Using AAO as a covariate, a linkage signal for AD has been detected on chromosome 14q32 near the alpha1-antichymotrypsin (ACT) gene. Previously, a signal peptide polymorphism (codon -17A>T) in the ACT gene has been suggested to affect AD risk, but with inconsistent findings. Given that a linkage signal for AAO has been detected near ACT, we hypothesized that ACT genetic variation affects AAO rather than disease risk and this may explain the previous inconsistent findings between ACT genetic variation and AD risk. We examined the impact of the ACT signal peptide polymorphism on mean AAO in 909 AD cases. The ACT polymorphism was significantly associated with AAO and this effect was independent of the APOE polymorphism. Mean AAO among ACT/AA homozygotes was significantly lower than that in the combined AT+TT genotype group (p = 0.019) and this difference was confined to male AD patients (p = 0.002). Among male AD patients, the ACT/AA genotype was also associated with shorter disease duration before death as compared to the ACT/AT+TT genotypes (p = 0.012). These data suggest that the ACT gene may affect AAO and disease duration of AD.

Alpha-1-antichymotrypsin (ACT or SERPINA3) polymorphism may affect age-at-onset and disease duration of Alzheimer’s disease

PubMed Central

Kamboh, M. Ilyas; Minster, Ryan L.; Kenney, Margaret; Ozturk, Ayla; Desai, Purnima P.; Kammerer, Candace M.; DeKosky, Steven T.

2006-01-01

In addition to genetic effects on disease risk, age-at-onset (AAO) of Alzheimer’s disease (AD) is also genetically controlled. Using AAO as a covariate, a linkage signal for AD has been detected on chromosome 14q32 near the a1-antichymotrypsin (ACT) gene. Previously, a signal peptide polymorphism (codon -17A>T) in the ACT gene has been suggested to affect AD risk, but with inconsistent findings. Given that a linkage signal for AAO has been detected near ACT, we hypothesized that ACT genetic variation affects AAO rather than disease risk and this may explain the previous inconsistent findings between ACT genetic variation and AD risk. We examined the impact of the ACT signal peptide polymorphism on mean AAO in 909 AD cases. The ACT polymorphism was significantly associated with AAO and this effect was independent of the APOE polymorphism. Mean AAO among ACT/AA homozygotes was significantly lower than that in the combined AT+TT genotype group (p=0.019) and this difference was confined to male AD patients (p=0.002). Among male AD patients, the ACT/AA genotype was also associated with shorter disease duration before death as compared to the ACT/AT + TT genotypes (p=0.012). These data suggest that the ACT gene may affect AAO and disease duration of AD. PMID:16137793

29 CFR 4.104 - What the Act provides, generally.

Code of Federal Regulations, 2010 CFR

2010-07-01

... McNamara-O'Hara Service Contract Act Introductory § 4.104 What the Act provides, generally. The provisions of the Act apply to contracts, whether negotiated or advertised, the principal purpose of which is to... contract subject to the Act (and any bid specification therefor) entered into by the United States or the...

18 CFR 380.13 - Compliance with the Endangered Species Act.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Endangered Species Act. 380.13 Section 380.13 Conservation of Power and Water Resources FEDERAL ENERGY... ENVIRONMENTAL POLICY ACT § 380.13 Compliance with the Endangered Species Act. (a) Definitions. For purposes of... Species Act of 1973, as amended (ESA). (2) Consultation requirement. (i) Prior to the filing of the...

18 CFR 380.13 - Compliance with the Endangered Species Act.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Endangered Species Act. 380.13 Section 380.13 Conservation of Power and Water Resources FEDERAL ENERGY... ENVIRONMENTAL POLICY ACT § 380.13 Compliance with the Endangered Species Act. (a) Definitions. For purposes of... Species Act of 1973, as amended (ESA). (2) Consultation requirement. (i) Prior to the filing of the...

50 CFR 697.3 - Relation to other Federal and state laws.

Code of Federal Regulations, 2011 CFR

2011-10-01

... CFR part 229 issued pursuant to the Marine Mammal Protection Act (MMPA) and the Endangered Species Act... sections 307 through 311 of the Magnuson-Stevens Act, as amended, regarding prohibited acts, civil... this part, as if the regulations in this part were issued under the Magnuson-Stevens Act. (b) The...

18 CFR 380.13 - Compliance with the Endangered Species Act.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Endangered Species Act. 380.13 Section 380.13 Conservation of Power and Water Resources FEDERAL ENERGY... ENVIRONMENTAL POLICY ACT § 380.13 Compliance with the Endangered Species Act. (a) Definitions. For purposes of... Species Act of 1973, as amended (ESA). (2) Consultation requirement. (i) Prior to the filing of the...

18 CFR 380.13 - Compliance with the Endangered Species Act.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Endangered Species Act. 380.13 Section 380.13 Conservation of Power and Water Resources FEDERAL ENERGY... ENVIRONMENTAL POLICY ACT § 380.13 Compliance with the Endangered Species Act. (a) Definitions. For purposes of... Species Act of 1973, as amended (ESA). (2) Consultation requirement. (i) Prior to the filing of the...

50 CFR 697.3 - Relation to other Federal and state laws.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CFR part 229 issued pursuant to the Marine Mammal Protection Act (MMPA) and the Endangered Species Act... sections 307 through 311 of the Magnuson-Stevens Act, as amended, regarding prohibited acts, civil... this part, as if the regulations in this part were issued under the Magnuson-Stevens Act. (b) The...

18 CFR 380.13 - Compliance with the Endangered Species Act.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Endangered Species Act. 380.13 Section 380.13 Conservation of Power and Water Resources FEDERAL ENERGY... ENVIRONMENTAL POLICY ACT § 380.13 Compliance with the Endangered Species Act. (a) Definitions. For purposes of... Species Act of 1973, as amended (ESA). (2) Consultation requirement. (i) Prior to the filing of the...

17 CFR 210.12-12A - Investments-securities sold short.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Investments-securities sold... EXCHANGE ACT OF 1934, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935, INVESTMENT COMPANY ACT OF 1940, INVESTMENT ADVISERS ACT OF 1940, AND ENERGY POLICY AND CONSERVATION ACT OF 1975 Form and Content of Schedules...

31 CFR 561.312 - Act of international terrorism.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Act of international terrorism. 561... General Definitions § 561.312 Act of international terrorism. For purposes of this part, the term act of international terrorism has the same definition as that provided under section 14 of the Iran Sanctions Act of...

17 CFR 210.12-12A - Investments-securities sold short.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Investments-securities sold... EXCHANGE ACT OF 1934, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935, INVESTMENT COMPANY ACT OF 1940, INVESTMENT ADVISERS ACT OF 1940, AND ENERGY POLICY AND CONSERVATION ACT OF 1975 Form and Content of Schedules...