Science.gov

Sample records for act rcra regulated

  1. Overview of the regulation of hazardous chemicals: SDWA (Safe Drinking Water Act), RCRA (Resource Conservation and Recovery Act), and CERCLA (Comprehensive Environmental Response, Compensation, and Liability Act)

    SciTech Connect

    Baes, C.F. III

    1989-01-01

    The regulation of nonradioactive hazardous chemicals is carried out under a number of federal environmental laws that regulate either hazardous products, substances, or wastes. Because each law is intended to provide protection from different classes of substances (e.g., wastes vs products) or protect different media (e.g., air, water, land), the standards and levels of protection for different hazardous chemicals may be different. Nevertheless, one agency -- the Environmental Protection Agency (EPA) -- has primary responsibility for both promulgating regulations mandated by Congress under the various statutes and enforcement of the regulations. One overriding principal underlies the maze of complex regulations that govern the transport, treatment, storage, and disposal of hazardous substances: protect human health and the environment. It is beyond the scope of this talk to comprehensively examine all of the regulations and standards that govern the management of hazardous chemicals. Instead this discussion will focus on three statutes, the Safe Drinking Water Act (SDWA), the Resource Conservation and Recovery Act (RCRA), and the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), that together provide a basis for a basic understanding of the approach that the EPA takes to regulating hazardous chemicals.

  2. 10 CFR 600.149 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Resource Conservation and Recovery Act (RCRA). 600.149 Section 600.149 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES... Conservation and Recovery Act (RCRA). Recipients' procurements shall comply with applicable requirements...

  3. 10 CFR 600.149 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Resource Conservation and Recovery Act (RCRA). 600.149 Section 600.149 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES... Conservation and Recovery Act (RCRA). Recipients' procurements shall comply with applicable requirements...

  4. 76 FR 42138 - Notice of Lodging of Consent Decree Under The Resource Conservation and Recovery Act (RCRA)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-18

    ... of Lodging of Consent Decree Under The Resource Conservation and Recovery Act (RCRA) In accordance... Conservation and Recovery Act (``RCRA'') Section 3008(a), 42 U.S.C. 6928(a), and the federal regulations... RCRA Section 3004(d), 42 U.S.C. 6924(d), and Fla. Stat. Chapter 403 ] (Environmental Control), Part...

  5. Day-to-day compliance with Resource Conservation Recovery Act (RCRA)

    SciTech Connect

    Harris, W.E.; Hart, J.T.

    1995-12-31

    Day-to-day compliance with requirements of the Resource Conservation Recovery Act (RCRA) is an important, yet difficult, component of environmental compliance. Non-compliance with RCRA can result in substantial financial penalties and/or major costs associated with clean-up of contaminated facilities. This session will include a review of all of the major RCRA, hazardous waste generator requirements and selected TSD requirements. Emphasis will be placed on requirements which regulated industries routinely fail and on which penalties for non- compliance may be levied. Specific procedures and suggestions for assuring continued compliance will be presented. Also included is a review of the RCRA waste characterization requirements and means for assuring compliance. Finally, examples of specific RCRA enforcement actions will be presented along with an explanation of how RCRA penalties are calculated and how RCRA penalties can be mitigated.

  6. 32 CFR 32.16 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Resource Conservation and Recovery Act (RCRA... Resource Conservation and Recovery Act (RCRA). Recipients' procurements shall comply with applicable requirements of the Resource Conservation and Recovery Act (RCRA), as described at § 32.49....

  7. 32 CFR 32.16 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Resource Conservation and Recovery Act (RCRA... Resource Conservation and Recovery Act (RCRA). Recipients' procurements shall comply with applicable requirements of the Resource Conservation and Recovery Act (RCRA), as described at § 32.49....

  8. 32 CFR 32.16 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Resource Conservation and Recovery Act (RCRA... Resource Conservation and Recovery Act (RCRA). Recipients' procurements shall comply with applicable requirements of the Resource Conservation and Recovery Act (RCRA), as described at § 32.49....

  9. 32 CFR 32.16 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Resource Conservation and Recovery Act (RCRA... Resource Conservation and Recovery Act (RCRA). Recipients' procurements shall comply with applicable requirements of the Resource Conservation and Recovery Act (RCRA), as described at § 32.49....

  10. 32 CFR 32.16 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Resource Conservation and Recovery Act (RCRA... Resource Conservation and Recovery Act (RCRA). Recipients' procurements shall comply with applicable requirements of the Resource Conservation and Recovery Act (RCRA), as described at § 32.49....

  11. 10 CFR 600.149 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Resource Conservation and Recovery Act (RCRA). 600.149... Conservation and Recovery Act (RCRA). Recipients' procurements shall comply with applicable requirements of RCRA, as described at § 600.116 of this subpart. Reports and Records...

  12. 10 CFR 600.149 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Resource Conservation and Recovery Act (RCRA). 600.149... Conservation and Recovery Act (RCRA). Recipients' procurements shall comply with applicable requirements of RCRA, as described at § 600.116 of this subpart. Reports and Records...

  13. 38 CFR 49.16 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Environmental Protection Agency (EPA) (40 CFR parts 247-254). Accordingly, State and local institutions of... Recovery Act (RCRA). 49.16 Section 49.16 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS... Conservation and Recovery Act (RCRA). Under the RCRA (Pub. L. 94-580, codified at 42 U.S.C. 6962), any...

  14. 38 CFR 49.16 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Environmental Protection Agency (EPA) (40 CFR parts 247-254). Accordingly, State and local institutions of... Recovery Act (RCRA). 49.16 Section 49.16 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS... Conservation and Recovery Act (RCRA). Under the RCRA (Pub. L. 94-580, codified at 42 U.S.C. 6962), any...

  15. 10 CFR 600.149 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Resource Conservation and Recovery Act (RCRA). 600.149... Conservation and Recovery Act (RCRA). Recipients' procurements shall comply with applicable requirements of RCRA, as described at § 600.116 of this subpart. Reports and Records...

  16. Resource Conservation and Recovery Act (RCRA) new-employee training manual for the Operations Division RCRA personnel

    SciTech Connect

    Barkenbus, B.D.

    1987-03-01

    This manual has been prepared for the training of new employees who will work with RCRA hazardous waste management in the Operations Division. It will be taught by a person who is trained in hazardous waste regulations/procedures. It consists of nine modules. The topics of these modules are: RCRA Training, Hazardous Waste Regulations, Transportation Regulations, Hazardous Waste Management at ORNL, Chemical Hazards and Safety, Hazardous Waste Operations Training, Sampling of Hazardous Waste, Hazardous Waste Identification/Classification, and RCRA Contingency Plans and Emergency Procedures. The on-the-job training areas are identified in the modules. They are an integral part of training.

  17. 15 CFR 14.16 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... recycled materials identified in guidelines developed by the Environmental Protection Agency (EPA) (40 CFR... (RCRA). 14.16 Section 14.16 Commerce and Foreign Trade Office of the Secretary of Commerce UNIFORM... Act (RCRA). Under RCRA (Pub. L. 94-580, 42 U.S.C. 6962), any State agency or agency of a...

  18. 15 CFR 14.16 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... recycled materials identified in guidelines developed by the Environmental Protection Agency (EPA) (40 CFR... (RCRA). 14.16 Section 14.16 Commerce and Foreign Trade Office of the Secretary of Commerce UNIFORM... Act (RCRA). Under RCRA (Pub. L. 94-580, 42 U.S.C. 6962), any State agency or agency of a...

  19. 15 CFR 14.16 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... recycled materials identified in guidelines developed by the Environmental Protection Agency (EPA) (40 CFR... (RCRA). 14.16 Section 14.16 Commerce and Foreign Trade Office of the Secretary of Commerce UNIFORM... Act (RCRA). Under RCRA (Pub. L. 94-580, 42 U.S.C. 6962), any State agency or agency of a...

  20. 15 CFR 14.16 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... recycled materials identified in guidelines developed by the Environmental Protection Agency (EPA) (40 CFR... (RCRA). 14.16 Section 14.16 Commerce and Foreign Trade Office of the Secretary of Commerce UNIFORM... Act (RCRA). Under RCRA (Pub. L. 94-580, 42 U.S.C. 6962), any State agency or agency of a...

  1. RCRA, Superfund and EPCRA hotline training module. Introduction to: Oil Pollution Prevention Regulation and the Oil Pollution Act of 1990 (updated February 1998); Directive

    SciTech Connect

    1998-06-01

    The goal of this module is to explain the purpose, scope, and reporting requirements under the Spill Prevention Control and Countermeasures (SPCC) and related regulations and the Oil Pollution Act of 1990.

  2. 40 CFR 30.16 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Resource Conservation and Recovery Act... Conservation and Recovery Act (RCRA). Resource Conservation and Recovery Act (RCRA) (Public Law 94-580 codified... materials identified in guidelines developed by EPA (40 CFR parts 247 through 254). Accordingly, State...

  3. 40 CFR 30.16 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Resource Conservation and Recovery Act... Conservation and Recovery Act (RCRA). Resource Conservation and Recovery Act (RCRA) (Public Law 94-580 codified... materials identified in guidelines developed by EPA (40 CFR parts 247 through 254). Accordingly, State...

  4. 40 CFR 30.16 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Resource Conservation and Recovery Act... HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pre-Award Requirements § 30.16 Resource Conservation and Recovery Act (RCRA). Resource Conservation and Recovery Act (RCRA) (Public Law 94-580...

  5. 40 CFR 30.16 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Resource Conservation and Recovery Act... HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pre-Award Requirements § 30.16 Resource Conservation and Recovery Act (RCRA). Resource Conservation and Recovery Act (RCRA) (Public Law 94-580...

  6. 40 CFR 30.16 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Conservation and Recovery Act (RCRA). Resource Conservation and Recovery Act (RCRA) (Public Law 94-580 codified... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Resource Conservation and Recovery Act... materials identified in guidelines developed by EPA (40 CFR parts 247 through 254). Accordingly, State...

  7. 14 CFR 1260.116 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Resource Conservation and Recovery Act... Requirements § 1260.116 Resource Conservation and Recovery Act (RCRA). Under the RCRA (Pub. L. 94-580 codified... recycled materials identified in guidelines developed by the Environmental Protection Agency (EPA) (40...

  8. 14 CFR § 1260.116 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Resource Conservation and Recovery Act... Requirements § 1260.116 Resource Conservation and Recovery Act (RCRA). Under the RCRA (Pub. L. 94-580 codified... recycled materials identified in guidelines developed by the Environmental Protection Agency (EPA) (40...

  9. 14 CFR 1260.116 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... recycled materials identified in guidelines developed by the Environmental Protection Agency (EPA) (40 CFR... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Resource Conservation and Recovery Act... Requirements § 1260.116 Resource Conservation and Recovery Act (RCRA). Under the RCRA (Pub. L. 94-580...

  10. General requirements for RCRA regulated hazardous waste tanks

    SciTech Connect

    1995-11-01

    The Resource Conservation and Recovery Act (RCRA), as amended, requires that tanks used for the storage or treatment of hazardous waste (HazW) be permitted, and comply with the requirements contained within the Code of Federal Regulations (CFR) TItle 40 in Subpart J of Part 264/265, unless those tanks have been exempted. Subpart J specifies requirements for the design, construction, installation, operation, inspection, maintenance, repair, release, response, and closure of HazW tanks. Also, the regulations make a distinction between new and existing tanks. Effective December 6, 1995, standards for controlling volatile organic air emissions will apply to non-exempt HazW tanks. HazW tanks will have to be equipped with a cover or floating roof, or be designed to operate as a closed system, to be in compliance with the air emission control requirements. This information brief describes those tanks that are subject to the Subpart J requirements, and will also discuss secondary containment, inspection, restrictions on waste storage, release response, and closure requirements associated with regulated HazW tanks.

  11. Small-quantity generator's handbook for managing RCRA (Resource Conservation and Recovery Act) wastes. Pesticide application

    SciTech Connect

    Not Available

    1988-06-01

    This RCRA Handbook was developed for pesticide applicators to provide assistance in complying with pertinent sections of the RCRA requirements. Section 2 summarizes operations of pesticide users and describes potential waste types that could be generated from these operations. Section 3 provides a guide for determining if a particular pesticide waste is subject to these regulations. Section 4 discusses the RCRA generator requirements, while Section 5 describes waste-management strategies for minimizing the amount of hazardous waste generated by the pesticide applicators. Appendix A lists hazardous wastes. Appendix B summarizes RCRA characteristic wastes. Appendix C contains a list of references and contacts for obtaining more information about hazardous wastes and their regulation.

  12. 38 CFR 49.16 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Resource Conservation and... Conservation and Recovery Act (RCRA). Under the RCRA (Pub. L. 94-580, codified at 42 U.S.C. 6962), any State... Environmental Protection Agency (EPA) (40 CFR parts 247-254). Accordingly, State and local institutions...

  13. 38 CFR 49.16 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2014-07-01 2014-07-01 false Resource Conservation and... Conservation and Recovery Act (RCRA). Under the RCRA (Pub. L. 94-580, codified at 42 U.S.C. 6962), any State... Environmental Protection Agency (EPA) (40 CFR parts 247-254). Accordingly, State and local institutions...

  14. 38 CFR 49.16 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2012-07-01 2012-07-01 false Resource Conservation and... Conservation and Recovery Act (RCRA). Under the RCRA (Pub. L. 94-580, codified at 42 U.S.C. 6962), any State... Environmental Protection Agency (EPA) (40 CFR parts 247-254). Accordingly, State and local institutions...

  15. HANFORD TANK FARM RESOURCE CONVERVATION & RECOVERY ACT (RCRA) CORRECTIVE ACTION PROGRAM

    SciTech Connect

    KRISTOFZSKI, J.G.

    2007-01-15

    As a consequence of producing special nuclear material for the nation's defense, large amounts of extremely hazardous radioactive waste was created at the US Department of Energy's (DOE) Hanford Site in south central Washington State. A little over 50 million gallons of this waste is now stored in 177 large, underground tanks on Hanford's Central Plateau in tank farms regulated under the Atomic Energy Act and the Resource, Conservation, and Recovery Act (RCRA). Over 60 tanks and associated infrastructure have released or are presumed to have released waste in the vadose zone. In 1998, DOE's Office of River Protection established the Hanford Tank Farm RCRA Corrective Action Program (RCAP) to: (1) characterize the distribution and extent of the existing vadose zone contamination; (2) determine how the contamination will move in the future; (3) estimate the impacts of this contamination on groundwater and other media; (4) develop and implement mitigative measures; and (5) develop corrective measures to be implemented as part of the final closure of the tank farm facilities. Since its creation, RCAP has made major advances in each of these areas, which will be discussed in this paper.

  16. 14 CFR 1260.116 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Resource Conservation and Recovery Act (RCRA). 1260.116 Section 1260.116 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION... Agreements With Institutions of Higher Education, Hospitals, and Other Non-Profit Organizations...

  17. 14 CFR 1260.116 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Resource Conservation and Recovery Act (RCRA). 1260.116 Section 1260.116 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS... With Institutions of Higher Education, Hospitals, and Other Non-Profit Organizations...

  18. Resource Conservation and Recovery Act (RCRA) Closure Plan Summary for Interim reasctive Waste Treatment Area (IRWTA)

    SciTech Connect

    Collins, E.T.

    1997-07-01

    This closure plan has been prepared for the interim Reactive Waste Treatment Area (IRWT'A) located at the Y-12 Pkmt in oak Ridge, Tennessee (Environmental Protection Agency [EPA] Identification TN 389-009-0001). The actions required to achieve closure of the IRWTA are outlined in this plan, which is being submitted in accordance with Tennessee Ruie 1200- 1-1 1-.0S(7) and Title 40, Code of Federal Regulations (CFR), Part 265, Subpart G. The IRWTA was used to treat waste sodium and potassium (NaK) that are regulated by the Resource Conservation and Recovery Act (RCRA). The location of the IRWT'A is shown in Figures 1 and 2, and a diagram is shown in Figure 3. This pkm details all steps that wdi be petiormed to close the IRWTA. Note that this is a fmai ciosure.and a diagram is shown in Figure 3. This pkm details all steps that wdi be petiormed to close the IRWTA. Note that this is a fmai ciosure.

  19. Characterization of MGP (manufactured gas plant) residues using proposed RCRA (Resource Conservation Recovery Act) tests. Topical report, May 1987-February 1989. Final report

    SciTech Connect

    Lew, L.R.; Gould, J.E.

    1989-03-01

    The U.S. Environment Protection Agency (EPA) has proposed two tests that may affect the regulation of residues associated with manufactured gas plant (MGP) sites which are not currently regulated by the Resource Conservation Recovery Act (RCRA): the Toxicity Characteristic Leaching Procedure (TCLP) and a revised reactivity test which includes interim guidance levels for reactive cyanide and sulfide as well as methods for determining reactive levels. Atlantic Environmental Services, Inc, carried out a research project under the Gas Research Institute program for the management of MGP sites. Several samples were tested using the proposed TCLP to determine the likelihood that MGP residues would be characterized as RCRA wastes under the new procedures. The reactivity tests for cyanide and sulfide also were run on samples collected from MGP sites to determine whether these specific residues would fall based on the revised technique. The results of the study are presented.

  20. Closure of municipal solid waste landfills (MSWLFs). RCRA Information Brief

    SciTech Connect

    Petts, M.

    1993-07-01

    This RCRA (Resource Conservation and Recovery Act) information brief answers some questions regarding the 40 CFR 258 and 40 CFR 257 regulations on solid waste disposal facilities and their closure/cover. Section 405 of the Clean Water Act is covered as well as the RCRA.

  1. 45 CFR 74.16 - Resource Conservation and Recovery Act (RCRA, Section 6002 of Pub. L. No. 94-580 (Codified at 42...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Environmental Protection Agency (EPA) (40 CFR parts 247-254). Accordingly, State and local institutions of... 45 Public Welfare 1 2010-10-01 2010-10-01 false Resource Conservation and Recovery Act (RCRA... COMMERCIAL ORGANIZATIONS Pre-Award Requirements § 74.16 Resource Conservation and Recovery Act (RCRA,...

  2. 43 CFR 12.916 - Resource Conservation and Recovery Act (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... developed by the Environmental Protection Agency (EPA) (40 CFR parts 247-254). Accordingly, State and local... (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962). 12.916 Section 12.916 Public Lands: Interior Office... Conservation and Recovery Act (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962). Under the Act, any...

  3. 45 CFR 74.16 - Resource Conservation and Recovery Act (RCRA, Section 6002 of Pub. L. No. 94-580 (Codified at 42...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Environmental Protection Agency (EPA) (40 CFR parts 247-254). Accordingly, State and local institutions of... 45 Public Welfare 1 2011-10-01 2011-10-01 false Resource Conservation and Recovery Act (RCRA... COMMERCIAL ORGANIZATIONS Pre-Award Requirements § 74.16 Resource Conservation and Recovery Act (RCRA,...

  4. 45 CFR 74.16 - Resource Conservation and Recovery Act (RCRA, Section 6002 of Pub. L. No. 94-580 (Codified at 42...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Environmental Protection Agency (EPA) (40 CFR parts 247-254). Accordingly, State and local institutions of... 45 Public Welfare 1 2013-10-01 2013-10-01 false Resource Conservation and Recovery Act (RCRA... COMMERCIAL ORGANIZATIONS Pre-Award Requirements § 74.16 Resource Conservation and Recovery Act (RCRA,...

  5. 45 CFR 74.16 - Resource Conservation and Recovery Act (RCRA, Section 6002 of Pub. L. No. 94-580 (Codified at 42...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Environmental Protection Agency (EPA) (40 CFR parts 247-254). Accordingly, State and local institutions of... 45 Public Welfare 1 2012-10-01 2012-10-01 false Resource Conservation and Recovery Act (RCRA... COMMERCIAL ORGANIZATIONS Pre-Award Requirements § 74.16 Resource Conservation and Recovery Act (RCRA,...

  6. 43 CFR 12.916 - Resource Conservation and Recovery Act (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... developed by the Environmental Protection Agency (EPA) (40 CFR parts 247-254). Accordingly, State and local... (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962). 12.916 Section 12.916 Public Lands: Interior Office... Conservation and Recovery Act (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962). Under the Act, any...

  7. 45 CFR 74.16 - Resource Conservation and Recovery Act (RCRA, Section 6002 of Pub. L. No. 94-580 (Codified at 42...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Environmental Protection Agency (EPA) (40 CFR parts 247-254). Accordingly, State and local institutions of... 45 Public Welfare 1 2014-10-01 2014-10-01 false Resource Conservation and Recovery Act (RCRA... COMMERCIAL ORGANIZATIONS Pre-Award Requirements § 74.16 Resource Conservation and Recovery Act (RCRA,...

  8. 43 CFR 12.916 - Resource Conservation and Recovery Act (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... developed by the Environmental Protection Agency (EPA) (40 CFR parts 247-254). Accordingly, State and local... (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962). 12.916 Section 12.916 Public Lands: Interior Office... Conservation and Recovery Act (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962). Under the Act, any...

  9. 43 CFR 12.916 - Resource Conservation and Recovery Act (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... developed by the Environmental Protection Agency (EPA) (40 CFR parts 247-254). Accordingly, State and local... (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962). 12.916 Section 12.916 Public Lands: Interior Office... Conservation and Recovery Act (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962). Under the Act, any...

  10. 43 CFR 12.916 - Resource Conservation and Recovery Act (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... developed by the Environmental Protection Agency (EPA) (40 CFR parts 247-254). Accordingly, State and local... (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962). 12.916 Section 12.916 Public Lands: Interior Office... Conservation and Recovery Act (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962). Under the Act, any...

  11. 28 CFR 70.16 - Resource Conservation and Recovery Act (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... guidelines developed by the Environmental Protection Agency (EPA) (40 CFR parts 247-254). Accordingly, State... (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962). 70.16 Section 70.16 Judicial Administration... Requirements § 70.16 Resource Conservation and Recovery Act (RCRA) (Pub. L. 94-580 codified at 42 U.S.C....

  12. 28 CFR 70.16 - Resource Conservation and Recovery Act (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... guidelines developed by the Environmental Protection Agency (EPA) (40 CFR parts 247-254). Accordingly, State... (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962). 70.16 Section 70.16 Judicial Administration... Requirements § 70.16 Resource Conservation and Recovery Act (RCRA) (Pub. L. 94-580 codified at 42 U.S.C....

  13. 28 CFR 70.16 - Resource Conservation and Recovery Act (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... guidelines developed by the Environmental Protection Agency (EPA) (40 CFR parts 247-254). Accordingly, State... (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962). 70.16 Section 70.16 Judicial Administration... Requirements § 70.16 Resource Conservation and Recovery Act (RCRA) (Pub. L. 94-580 codified at 42 U.S.C....

  14. 28 CFR 70.16 - Resource Conservation and Recovery Act (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... guidelines developed by the Environmental Protection Agency (EPA) (40 CFR parts 247-254). Accordingly, State... (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962). 70.16 Section 70.16 Judicial Administration... Requirements § 70.16 Resource Conservation and Recovery Act (RCRA) (Pub. L. 94-580 codified at 42 U.S.C....

  15. 28 CFR 70.16 - Resource Conservation and Recovery Act (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... guidelines developed by the Environmental Protection Agency (EPA) (40 CFR parts 247-254). Accordingly, State... (RCRA) (Pub. L. 94-580 codified at 42 U.S.C. 6962). 70.16 Section 70.16 Judicial Administration... Requirements § 70.16 Resource Conservation and Recovery Act (RCRA) (Pub. L. 94-580 codified at 42 U.S.C....

  16. NGLW RCRA Storage Study

    SciTech Connect

    R. J. Waters; R. Ochoa; K. D. Fritz; D. W. Craig

    2000-06-01

    The Idaho Nuclear Technology and Engineering Center (INTEC) at the Idaho National Engineering and Environmental Laboratory contains radioactive liquid waste in underground storage tanks at the INTEC Tank Farm Facility (TFF). INTEC is currently treating the waste by evaporation to reduce the liquid volume for continued storage, and by calcination to reduce and convert the liquid to a dry waste form for long-term storage in calcine bins. Both treatment methods and activities in support of those treatment operations result in Newly Generated Liquid Waste (NGLW) being sent to TFF. The storage tanks in the TFF are underground, contained in concrete vaults with instrumentation, piping, transfer jets, and managed sumps in case of any liquid accumulation in the vault. The configuration of these tanks is such that Resource Conservation and Recovery Act (RCRA) regulations apply. The TFF tanks were assessed several years ago with respect to the RCRA regulations and they were found to be deficient. This study considers the configuration of the current tanks and the RCRA deficiencies identified for each. The study identifies four potential methods and proposes a means of correcting the deficiencies. The cost estimates included in the study account for construction cost; construction methods to minimize work exposure to chemical hazards, radioactive contamination, and ionizing radiation hazards; project logistics; and project schedule. The study also estimates the tank volumes benefit associated with each corrective action to support TFF liquid waste management planning.

  17. NEPA/CERCLA/RCRA (National Environmental Policy Act/Comprehensive Environmental Response, Compensation, and Liability Act/Resource Conservation and Recovery Act) integration

    SciTech Connect

    Sharples, F.E.; Smith, E.D.

    1989-01-01

    The Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) requires that decisions concerning remedial actions at Superfund sites be made through a formal decisionmaking process known as Remedial Investigation/Feasibility Study (RI/FS). Many of the elements of this process are similar to the steps in the process required to comply with the National Environmental Policy Act (NEPA). Both processes, for example, involve the identification and analysis of alternative courses of action, provide for public disclosure and participation in the processes, and are documented by Records of Decision. This document discusses the applicability of NEPA to federal facility remedial actions and the advisability of integrating the NEPA process with the CERCLA and RCRA processes. Included are points addressed by panelists and recent developments. 3 refs.

  18. RCRA hazardous waste contingency plans

    SciTech Connect

    Wagner, T.P. )

    1991-10-01

    This paper reports that the Resource Conservation and Recovery Act (RCRA) requires hazardous waste treatment, storage and disposal facilities (TSDFs) to prepare a contingency plan. The plan is a blueprint for emergency response, and must be designed to minimize health and environmental hazards resulting from fires, explosions or other unplanned hazardous releases. Hazardous waste contingency plans often are neglected and considered an unnecessary regulatory exercise by facility operators. However, an effective contingency plan is a valuable tool for reducing liability, protecting workers and the community, and avoiding costly shutdowns. The requirement under Title III of the Superfund Amendments and Reauthorization Act (SARA) that regulated facilities report to EPA annually on releases to the environment has caused regulators to renew emphasis on the importance of RCRA contingency plans. However, regulatory agencies historically have provided insufficient information on the elements of an adequate contingency plan. Nevertheless, facility operators seriously should consider going beyond minimum regulatory requirements and create a comprehensive contingency plan.

  19. RCRA, superfund and EPCRA hotline training module. Introduction to: Other laws that interface with RCRA, updated July 1996

    SciTech Connect

    1996-07-01

    The module provides a brief overview of some of the major environmental laws that interface with RCRA: Clean Air Act (CAA); Clean Water Act (CWA); Safe Drinking Water Act (SDWA); Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA); Toxic Substances Control Act (TSCA); Pollution Prevention Act (PPA); and Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA or Superfund). It also covers regulations administered by other agencies that interface with RCRA, such as health and safety requirements under the occupational health and safety administration, and the hazardous materials transportation requirements administered by the Department of Transportation.

  20. Transportation of RCRA hazardous wastes. RCRA Information Brief

    SciTech Connect

    Not Available

    1994-04-01

    The Resource Conservation and Recovery Act (RCRA) and the Hazardous Materials Transportation Act (HMTA) regulate the transport of hazardous wastes. Under these statutes, specific pretransport regulatory requirements must be met by DOE before the shipment of hazardous wastes, including radioactive mixed wastes. The pretransport requirements are designed to help reduce the risk of loss, leakage, or exposure during shipment of hazardous materials and to communicate information on potential hazards posed by the hazardous material in transport. These goals are accomplished through the tracking of shipments, correctly packaging and labeling containers, and communicating potential hazards. Specific requirements include manifesting, packaging, marking and labeling waste packages; placarding transport vehicles; choosing appropriate waste transporters and shipment destinations; and record keeping and reporting. This information Brief focuses primarily on the transporter requirements both for transportation within a DOE facility and using a commercial transporter to transport RCRA hazardous wastes off-site.

  1. Resource Conservation and Recovery Act (RCRA) closure sumamry for the Uranium Treatment Unit

    SciTech Connect

    1996-05-01

    This closure summary has been prepared for the Uranium Treatment Unit (UTU) located at the Y-12 Plant in Oak Ridge, Tennessee. The actions required to achieve closure of the UTU area are outlined in the Closure Plan, submitted to and approved by the Tennessee Department of Environmental and Conservation staff, respectively. The UTU was used to store and treat waste materials that are regulated by the Resource Conservation and Recovery Act. This closure summary details all steps that were performed to close the UTU in accordance with the approved plan.

  2. Hazardous substance USTs: RCRA Subtitle 1, Underground Storage Tanks. RCRA Information Brief

    SciTech Connect

    Dailey, R.

    1994-01-01

    Underground tanks that contain petroleum or hazardous substances may be subject to the Federal Underground Storage Tank (UST) regulations. These regulations, issued by the Environmental Protection Agency (EPA) under authority of Subtitle I of the Resource Conservation and Recovery Act (RCRA) [Section 9003 of the Hazardous and Solid Waste Amendments of 1984 (HSWA)], established standards for installation, operation, release detection, corrective action, repair, and closure. The Department of Energy (DOE) is required by Section 9007 of RCRA to implement these regulations at DOE facilities with USTs.

  3. RCRA corrective action program guide (Interim)

    SciTech Connect

    Not Available

    1993-05-01

    The US Department of Energy (DOE) is responsible for compliance with an increasingly complex spectrum of environmental regulations. One of the most complex programs is the corrective action program proposed by the US Environmental Protection Agency (EPA) under the authority of the Resource Conservation and Recovery Act (RCRA) as amended by the Hazardous and Solid Waste Amendments (HSWA). The proposed regulations were published on July 27, 1990. The proposed Subpart S rule creates a comprehensive program for investigating and remediating releases of hazardous wastes and hazardous waste constituents from solid waste management units (SWMUs) at facilities permitted to treat, store, or dispose of hazardous wastes. This proposed rule directly impacts many DOE facilities which conduct such activities. This guidance document explains the entire RCRA Corrective Action process as outlined by the proposed Subpart S rule, and provides guidance intended to assist those persons responsible for implementing RCRA Corrective Action at DOE facilities.

  4. Exiting RCRA Subtitle C regulation data for supporting a new regulatory path for immobilized mixed debris

    SciTech Connect

    Porter, C.L.; Carson, S.D.; Cheng, Wu-Ching

    1995-12-31

    This paper presents analytical and empirical data that provide technical support for the position that mixed debris (debris contaminated with both radioactive and hazardous constituents) treated by immobilization in accordance with 40 CFR 268.45 can exit RCRA Subtitle C requirements at the time the treatment is complete. Pathways analyses and risk assessments of low-level waste and RCRA mixed waste disposal facilities show that these two types of facilities provide equivalent long-term (> 100 years) performance and protection of human health and the environment. A proposed two-tier approach for waste form performance criteria is discussed.

  5. RCRA/UST, superfund, and EPCRA hotline training module. Introduction to: Other laws that interface with RCRA, updated as of July 1995

    SciTech Connect

    1995-11-01

    The module provides a brief overview of some of the major environmental laws that interface with RCRA: Clean Air Act (CAA); Clean Water Act (CWA); Safe Drinking Water Act (SDWA); Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA); Toxic Substances Control Act (TSCA); Pollution Prevention Act (PPA); and Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA or Superfund). It also covers regulations administered by other agencies that interface with RCRA, such as health and safety requirements under the Occupational Health and Safety Administration, and the Hazardous Materials Transportation Requirements administered by the Department of Transportation.

  6. Impacts of proposed RCRA regulations and other related federal environmental regulations on Fossil Fuel-Fired Facilities: Final report, Volume 1

    SciTech Connect

    Not Available

    1987-03-01

    In order to fulfill its responsibilities, DOE contracted with Engineering-Science to perform a multi-phase engineering and economics study to evaluate the impact of the proposed RCRA regulations and other related federal environmental regulations on coal-fired utilities. This Interim Phase I report presents the findings of the impacts of proposed RCRA and related federal regulations on the utility sector fossil fuel-fired facilities. Subsequent phases involve parallel engineering studies on the industrial sector as well as economic evaluations. The framework of this study was based on the development and analysis (engineering and economic) of four regulatory scenarios for the disposal of fly ash, bottom ash and FGD sludge from the utility industry.

  7. Loss of interim status (LOIS) under RCRA. RCRA Information Brief

    SciTech Connect

    Not Available

    1992-09-01

    The Resource Conservation and Recovery Act (RCRA) requires owners and operators of facilities that treat store, or disposal of hazardous waste (TSDFs) to obtain an operating permit. Recognizing that it would take EPA many years to issue operating permits to all RCRA facilities, Congress created ``interim status`` under Section 3005(e) of the Act. Interim status allows facilities to operate under Subtitle C of RCRA until their permits are issued or denied. This information brief defines interim status and describes how failure to meet interim status requirements may lead to loss of interim status (LOIS).

  8. 15 CFR 14.16 - Resource Conservation and Recovery Act (RCRA).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Resource Conservation and Recovery Act...-PROFIT, AND COMMERCIAL ORGANIZATIONS Pre-Award Requirements § 14.16 Resource Conservation and Recovery... recycled materials identified in guidelines developed by the Environmental Protection Agency (EPA) (40...

  9. Resource Conservation and Recovery Act (RCRA) Part B permit application for tank storage units at the Oak Ridge Y-12 Plant

    SciTech Connect

    Not Available

    1994-05-01

    In compliance with the Resource Conservation and Recovery Act (RCRA), this report discusses information relating to permit applications for three tank storage units at Y-12. The storage units are: Building 9811-1 RCRA Tank Storage Unit (OD-7); Waste Oil/Solvent Storage Unit (OD-9); and Liquid Organic Solvent Storage Unit (OD-10). Numerous sections discuss the following: Facility description; waste characteristics; process information; groundwater monitoring; procedures to prevent hazards; contingency plan; personnel training; closure plan, post closure plan, and financial requirements; record keeping; other federal laws; organic air emissions; solid waste management units; and certification. Sixteen appendices contain such items as maps, waste analyses and forms, inspection logs, equipment identification, etc.

  10. RCRA, superfund and EPCRA hotline training module. Introduction to: RCRA statutory overview updated July 1996

    SciTech Connect

    1996-07-01

    The module presents a brief overview of the Resource Conservation and Recovery Act (RCRA). It explains the relationship between RCRA statutory language and codified regulatory language. It describes the major components of each subtitle of RCRA and identifies the major provisions established by the Hazardous and Solid Waste Amendments (HSWA).

  11. Annual report on performance audit results for POHC (Principal Organic Hazardous Constituents) testing during RCRA (Resource Conservation and Recovery Act) trial burns. Status report No. 2

    SciTech Connect

    Jayanty, R.K.M.; Tompkins, S.B.; Bryant, V.R.; Howe, G.B.

    1989-12-01

    Audit materials containing Principal Organic Hazardous Constituents (POHSc) have been developed by AREAL for use by federal, state, and local agencies or their contractors to assess the accuracy of measurement methods during Resource Conservation and Recovery Act (RCRA) trial burn tests. Audit materials are currently available for 27 gaseous organics in 5, 6, 7, and 9 component mixtures at parts-per-billion levels (7 to 10,000 ppb) in compressed gas cylinders in a balance gas of nitrogen. The criteria used for the selection of gaseous organic compounds is described. Stability studies indicate that all of the organics tested (with the exception of ethylene oxide and propylene oxide below 10 ppb levels) are stable enough to be used as reliable audit materials. Subsequent to completion of the stability studies, 202 performance audits have been initiated with the audit materials to assess the accuracy of the Volatile Organic Sampling Training and bag measurement methods during or prior to RCRA trial burn tests. Results of those audits and a summary table of the audit conducted for each POHC and the measurement system audited is described in the report. Audit results obtained with the audit bases during or prior to RCRA trial burn tests are generally within + or - 50% of the audit concentrations.

  12. House passes RCRA fix by wide margin

    SciTech Connect

    1996-02-07

    The House of Representatives has passed a bill to prevent expensive, court-ordered tightening of the Resource Conservation and Recovery Act`s (RCRA) land-disposal rules. The measure was initiated last March as part of the Clinton Administration`s {open_quotes}reinventing environmental regulation{close_quotes} initiative and was championed by House Republicans. It passed, 402 to 19, drawing overwhelming support from Democrats. CMA president and CEO Fred Webber hailed the bipartisan approach as the right way to legislate. {open_quotes}We hope this bill can serve as a model for Superfund and other pieces of unfinished business,{close_quotes} he says.

  13. Disemployment effects caused by regulation of drilling fluids and produced waters as hazardous under the Resource Conservation and Recovery Act

    SciTech Connect

    Flaim, S.J.

    1988-03-01

    This report reviews and compares several studies of the effects on employment of regulating wastes from oil and natural gas exploration and extraction under the Resource Conservation and Recovery Act (RCRA). The waste management scenarios on which most of the studies were based were developed by the U.S. Environmental Protection Agency. The analyses show that as many as 500,000-700,000 jobs may be lost in the first year if RCRA Subtitle C rules are applied to drilling fluids and produced waters. As a results, unemployment in major oil-producing states could rise by as much as six percentage points. 13 refs., 4 tabs.

  14. THE INTEGRATION OF THE 241-Z BUILDING DECONTAMINATION & DECOMMISSIONING (D&D) UNDER COMPREHENSIVE ENVIRONMENTAL RESPONSE COMPENSATION & LIABILITY ACT (CERCLA) WITH RESOURCE CONSERVATION & RECOVERY ACT (RCRA) CLOSURE AT THE PLUTONIUM FINISHING PLANT (PFP)

    SciTech Connect

    HOPKINS, A.M.

    2007-02-20

    The 241-Z treatment and storage tanks, a hazardous waste Treatment, Storage and Disposal (TSD) unit permitted pursuant to the ''Resource Conservation and Recovery Act of 1976'' (RCRA) and Washington State ''Hazardous Waste Management Act, RCW 70.105'', have been deactivated and are being actively decommissioned. The 241-Z TSD unit managed non-listed radioactive contaminated waste water, containing trace RCRA characteristic constituents. The 241-Z TSD unit consists of below grade tanks (D-4, D-5, D-7, D-8, and an overflow tank) located in a concrete containment vault, sample glovebox GB-2-241-ZA, and associated ancillary piping and equipment. The tank system is located beneath the 241-Z building. The 241-Z building is not a portion of the TSD unit. The sample glovebox is housed in the above-grade building. Waste managed at the TSD unit was received via underground mining from Plutonium Finishing Plant (PFP) sources. Tank D-6, located in the D-6 vault cell, is a past-practice tank that was taken out of service in 1972 and has never operated as a portion of the RCRA TSD unit. CERCLA actions address Tank D-6, its containment vault cell, and soil beneath the cell that was potentially contaminated during past-practice operations and any other potential past-practice contamination identified during 241-Z closure, while outside the scope of the ''Hanford Facility Dangerous Waste Closure Plant, 241-Z Treatment and Storage Tanks''.

  15. HANDBOOK: STABILIZATION TECHNOLOGIES FOR RCRA CORRECTIVE ACTIONS

    EPA Science Inventory

    On November 1984, Congress enacted the Hazardous and Solid Waste Amendments (HSWA) to the Resource Conservation and Recovery Act (RCRA). RCRA requires a corrective action program that prevents hazardous constituents from exceeding concentration limits at the compliance point (i.e...

  16. Single-laboratory evaluation of the RCRA (Resource Conservation and Recovery Act) method for analysis of dioxin in hazardous waste

    SciTech Connect

    Shore, F.L.; Vonnahme, T.L.; Hedin, C.M.; Donnelly, J.R.; Niederhut, W.J.

    1985-11-01

    Single-laboratory testing of RCRA Method 8280 for the analysis of chlorinated dibenzop-dioxins and dibenzofurans has been initiated on sample matrices including pottery clay soil, a Missouri soil, a fly ash, a still bottom from a chlorophenol-based herbicide production process, and an industrial process sludge. The analytical method was intended for use in the determination of chlorinated dioxin and dibenzofuran homologs with four, five, or six chlorine atoms per molecule. Revisions to the method that were found necessary for satisfactory analytical performance were developed and incorporated into a revised version of the method. Single-laboratory testing of method 8280 with minor revisions demonstrated satisfactory performance for the target analytes on soil and fly ash samples. Further modification and elaboration of sample cleanup procedures were necessary for analysis of the still bottom and industrial sludge samples.

  17. RCRA/UST, superfund, and EPCRA hotline training module. Introduction to: RCRA statutory overview, updated as of July 1995

    SciTech Connect

    1995-11-01

    The module presents a brief overview of the Resource Conservation and Recovery Act (RCRA). It explains the relationship between RCRA statutory language and codified regulatory language. It describes the major components of each subtitle of RCRA and identifies the major provisions established by the Hazardous and Solid Waste Amendments (HSWA).

  18. Criteria for municipal-solid-waste landfills (40 CFR Part 258). Subtitle D of Resource Conservation and Recovery Act (RCRA). Location restrictions (Subpart B). Draft report

    SciTech Connect

    Not Available

    1988-07-01

    In August 1988, the U.S. Environmental Protection Agency proposed Solid-Waste Disposal Facilities Criteria (40 CFR Part 258) for municipal-solid-waste landfills. This background document provides the technical support for Subpart 'B' - Location Restrictions of Part 258. The document contains a discussion of the legislative and regulatory background for understanding the current status of Subtitle D. A discussion of other Federal laws, besides the Resource Conservation and Recovery Act (RCRA), that impact the siting of municipal-waste landfills also is presented. The document also presents detailed information on the revised location restrictions. The location restrictions include the following: airport safety; floodplains; wetlands; fault areas; seismic-impact areas; and unstable areas.

  19. Petroleum USTs: RCRA Subtitle 1, Underground Storage Tanks. RCRA Information Brief

    SciTech Connect

    Dailey, R.

    1994-01-01

    Underground tanks that contain petroleum or hazardous substances may be subject to the Federal Underground Storage Tank (UST) regulations. These regulations, issued by EPA under authority of Subtitle I of the Resource Conservation and Recovery (RCRA) [Section 9003 of the Hazardous and Solid Waste Amendments Act of 1984 (HSWA)], establish standards for installation, operation, release detection, corrective action, repair, and closure. The Department of Energy (DOE) is required by Section 9007 of RCRA to implement these regulations at DOE facilities with USTs. DOE prepared a guidance document, Regulated Underground Storage Tanks (DOE/EH-231/0041/0191, June 1992), that describes the UST procedural requirements which regulate tanks and piping for both petroleum and hazardous substance USTs as well as USTs containing radioactive material regulated under the Atomic Energy Act of 1954 (42 USC 2011). This information Brief supplements the UST guidance by responding to critical questions concerning how the regulations apply to petroleum USTs. It is part of a series of information Briefs which address issues pertinent to specific categories of USTs.

  20. Hazardous substance USTs: RCRA Subtitle 1, Underground Storage Tanks. RCRA Information Brief

    SciTech Connect

    DiCerbo, J.

    1993-05-01

    Underground tanks that contain petroleum or hazardous substances may be subject to the Federal Underground Storage Tank (UST) regulations. These regulations, issued by the Environmental Protection Agency (EPA) under authority of Subtitle I of the Resource Conservation and Recovery Act (RCRA) [Section 9003 of the Hazardous an Solid Waste Amendments of 1984 (HSWA)], established standards for installation, operation, release detection corrective action, repair, and closure. The Department of Energy (DOE) is required by Section 9007 of RCRA t Implement these regulations at DOE facilities with USTs. DOE prepared a guidance document, Regulated Underground Storage Tanks (DOE/EH-231/004/0191, June 1992) that describes the UST procedural requirements which regulate tanks and piping for both petroleum and hazardous substance USTs as well as USTs containing radioactive material regulated under the Atomic Energy Act of 195 (42 U.S.C. 2011). This Information Brief supplements the UST guidance by responding to critical questions concerning how the regulations apply to hazardous substance USTs. It is a part of a series of Information Briefs which address issues pertinent to specific categories of USTs.

  1. Costs of RCRA corrective action: Interim report

    SciTech Connect

    Tonn, B.; Russell, M.; Hwang Ho-Ling; Goeltz, R. ); Warren, J. )

    1991-09-01

    This report estimates the cost of the corrective action provisions of the Resource Conservation and Recovery Act (RCRA) for all non-federal facilities in the United States. RCRA is the federal law which regulates the treatment, storage, disposal, and recovery of hazardous waste. The 1984 amendment to RCRA, known as the Hazardous and Solid Waste Amendments, stipulates that facilities that treat, store or dispose of hazardous wastes (TSDs) must remediate situations where hazardous wastes have escaped into the environment from their solid waste management units (SWMUs). The US Environmental Protection Agency (USEPA 1990a), among others, believes that the costs of RCRA corrective action could rival the costs of SUPERFUND. Evaluated herein are costs associated with actual remedial actions. The remedial action cost estimating program developed by CH2M Hill is known as the Cost of Remedial Action Model (CORA). It provides cost estimates, in 1987 dollars, by technology used to remediate hazardous waste sites. Rules were developed to categorize each SWMU in the RTI databases by the kinds of technologies that would be used to remediate them. Results were then run through CORA using various assumptions for variable values that could not be drawn from the RTI databases and that did not have CORA supplied default values. Cost estimates were developed under several scenarios. The base case assumes a TSD and SWMU universe equal to that captured in the RTI databases, a point of compliance at the SWMU boundary with no ability to shift wastes from SWMU to SWMU, and a best-as-practical clean-up to health-based standards. 11 refs., 12 figs., 12 tabs.

  2. RCRA, superfund and EPCRA hotline training module. Introduction to: Permits and interim status (40 cfr part 270) updated July 1996

    SciTech Connect

    1996-07-01

    Owners/operators of facilities that treat, store, or dispose of hazardous waste must obtain an operating permit, as required by Subtitle C of the Resource Conservation and Recovery Act (RCRA). The module presents an overview of the RCRA permitting process and the requirements that apply to TSDFs operating under interim status until a permit is issued. The regulations governing the permit process are found in 40 CFR Parts 124 through 270.

  3. 75 FR 37287 - Privacy Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-29

    ... April 19, 2010 (75 FR 20298) for a public comment period to end on June 18, 2010. This rule amends the... CFR Part 200 RIN 0430-AA03 Privacy Act Regulations AGENCY: Recovery Accountability and Transparency... regulations implementing the Privacy Act of 1974 (Privacy Act), Public Law 93-579, 5 U.S.C. 552a. This...

  4. RCRA, superfund and EPCRA hotline training module. Introduction to: Solid and hazardous waste exclusions (40 cfr section 261.4) updated July 1996

    SciTech Connect

    1996-07-01

    The Resources Conservation and Recovery Act`s (RCRA) Subtitle C hazardous waste management program is a comprehensive and carefully constructed system to ensure wastes are managed safely and lawfully. This program begins with a very specific, formal process to categorize wastes accurately and appropriately called waste identification. The module explains each waste exclusion and its scope, so you can apply this knowledge in determining whether a given waste is or is not regulated under RCRA Subtitle C.

  5. Revised legislation and new regulations for U.S. regulatory agencies: How it will economically impact the environmental industry, with a focus on the RCRA Corrective Action and Superfund programs

    SciTech Connect

    Parr, M.

    1996-12-31

    The 103rd and 104th Congresses have seen the vigorous discussion of several key environmental statutes and programs that have significant impact on the environmental services market. Superfund, RCRA Corrective Action, RCRA`s waste management standards for various hazardous wastes, the Clean Water Act, the Clean Air Act and the Safe Drinking Water Act have all been addressed in some manner. While, as of the date of this manuscript (late April, 1996), few actual legislative changes have occurred, the texture of the discussions is illustrative of where many of these programs are going. These changes have significant potential impacts on the environmental services market, and those impacts should generally be positive. The remainder of this discussion will focus on the two major remedial statues/programs; RCRA Corrective Action and Superfund.

  6. Calendar Year 2007 Resource Conservation and Recovery Act Annual Monitoring Report for the U.S. Department of Energy Y-12 National Security Complex, Oak Ridge, Tennessee - RCRA Post-Closure Permit Nos. TNHW-113, TNHW-116, and TNHW-128

    SciTech Connect

    Elvado Environmental

    2008-02-01

    This report contains groundwater quality monitoring data obtained during calendar year (CY) 2007 at the following hazardous waste treatment, storage, and disposal (TSD) units located at the US Department of Energy (DOE) Y-12 National Security Complex (hereafter referenced as Y-12) in Oak Ridge, Tennessee; this S-3 Site, Oil Landfarm, Bear Creek Burial Grounds/Walk-In Pits (BCBG/WIP), Eastern S-3 Site Plume, Chestnut Ridge Security Pits (CRSP), Chestnut Ridge Sediment Disposal Baste (CRSDB), few Hollow Quarry (KHQ), and East Chestnut Ridge Waste Pile (ECRWP). Hit monitoring data were obtained in accordance with the applicable Resource Conservation and Recovery Act of 1976 (RCRA) hazardous waste post-closure permit (PCP). The Tennessee Department of Environment and Conservation (TDEC) - Division of Solid Waste Management issued the PCPs to define the requirements for RCRA post-closure inspection, maintenance, and groundwater monitoring at the specified TSD units located within the Bear Creek Hydrogeologic Regime (PCP no. TNHW-116), Upper East Fork Poplar Creek Hydrogeologic Regime (PCP no. TNHW-113), and Chestnut Ridge Hydrogeologic Regime (PCP no. TNHW-128). Each PCP requires the Submittal of an annual RCRA groundwater monitoring report containing the groundwater sampling information and analytical results obtained at each applicable TSD unit during the preceding CY, along with an evaluation of groundwater low rates and directions and the analytical results for specified RCRA groundwater target compounds; this report is the RCRA annual groundwater monitoring report for CY 2007. The RCRA post-closure groundwater monitoring requirements specified in the above-referenced PCP for the Chestnut Ridge Regime replace those defined in the previous PCP (permit no. TNHW-088), which expired on September 18, 2005, but remained effective until the TDEC issued the new PCP in September 2006. The new PCP defines site-specific groundwater sampling and analysis requirements for the

  7. 75 FR 63703 - Privacy Act of 1974; Privacy Act Regulation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-18

    ... Federal Register, 73 FR 25594, May 7, 2008. The proposed amendments: (1) Waived all copying fees in..., 73 FR 54595, September 22, 2008, certain portions of BGFRS-37 (Electronic Applications) may be exempt... CFR Part 261a Privacy Act of 1974; Privacy Act Regulation AGENCY: Board of Governors of the...

  8. 75 FR 20298 - Privacy Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-19

    ...,'' pursuant to the Privacy Act, as amended (74 FR 60302, Nov. 20, 2009). The Board received no comments on...; ] RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD 4 CFR Part 200 RIN 0430-AA03 Privacy Act Regulations AGENCY... and Transparency Board (Board) proposes to amend the Board's regulations implementing the Privacy...

  9. Hanford Tank Farm RCRA Corrective Action Program

    SciTech Connect

    Kristofzski, J.R.; Mann, F.M.; Anderson, F.J.; Lober, R.W.

    2007-07-01

    As a consequence of producing special nuclear material for the nation's defense, large amounts of extremely hazardous radioactive waste was created at the U.S. Department of Energy's (DOE) Hanford Site in south central Washington State. A little over 50 million gallons of this waste is now stored in 177 large, underground tanks on Hanford's Central Plateau in tank farms regulated under the Atomic Energy Act and the Resource, Conservation, and Recovery Act (RCRA). Over 60 tanks and associated infrastructure have released or are presumed to have released waste in the vadose zone. In 1998, DOE's Office of River Protection established the Hanford Tank Farm RCRA Corrective Action Program (RCAP) to: - Characterize the distribution and extent of the existing vadose zone contamination; - Determine how the contamination will move in the future; - Estimate the impacts of this contamination on groundwater and other media; - Develop and implement mitigative measures; - Develop corrective measures to be implemented as part of the final closure of the tank farm facilities. Since its creation, RCAP has made major advances in each of these areas, which will be discussed in this paper. (authors)

  10. RCRA (Resource Conservation and Recovery Act of 1976) ground-water monitoring projects for Hanford facilities: Progress report, October 1--December 31, 1988: Volume 1, Text

    SciTech Connect

    Fruland, R.M.; Bates, D.J.; Lundgren, R.E.

    1989-04-01

    This report describes the progress of 13 Hanford ground-water monitoring projects for the period October 1 to December 31, 1988. There are 16 individual hazardous waste facilities covered by the 13 ground-water monitoring projects. The Grout Treatment Facility is included in this series of quarterly reports for the first time. The 13 projects discussed in this report were designed according to applicable interim-status ground-water monitoring requirements specified in the Resource Conservation and Recovery Act of 1976 (RCRA). During this quarter, field activities primarily consisted of sampling and analyses, and water-level monitoring. The 200 Areas Low-Level Burial Grounds section includes sediment analyses in addition to ground-water monitoring results. Twelve new wells were installed during the previous quarter: two at the 216-A-29 Ditch, six at the 216-A-10 Crib, and four at the 216-B-3 Pond. Preliminary characterization data for these new wells include drillers' logs and other drilling and site characterization data, and are provided in Volume 2 or on microfiche in the back of Volume 1. 26 refs., 28 figs., 74 tabs.

  11. Quarterly RCRA Groundwater Monitoring Data for the Period July through September 2006

    SciTech Connect

    Hartman, Mary J.

    2007-02-01

    This report provides information about RCRA groundwater monitoring for the period July through September 2006. Eighteen Resource Conservation and Recovery Act (RCRA) sites were sampled during the reporting quarter.

  12. Successful completion of a RCRA closure for the Fernald Environmental Management Project

    SciTech Connect

    Lippitt, J.M.; Kolthoff, K.

    1995-02-01

    This paper discusses the successful completion of a RCRA (Resource Conservation and Recovery Act) closure of a HF (hydrofluoric acid) tank car at FEMP, which is on the national priorities list of hazardous waste sites and is undergoing CERCLA remediation. The HF tank car closure was conducted by FERMCO. Through a combination of sound planning and team work, the HF tank car was closed safely and ahead of schedule. During > 22,000 hr field work required for construction modifications and neutralization of 9,600 gallons of HF and decontamination rinseates, there were no OSHA recordable incidents. The system design avoided additional costs by maximizing use of existing equipment and facilities. This successful closure of the HF tank car demonstrates FEMP`s commitment to reducing risks and cleaning up the facility in a manner consistent with objectives of RCRA regulations and the Ohio EPA hazardous waste rules. This in turn facilitated ongoing negotiations with Ohio EPA to integrate RCRA closure and the ongoing CERCLA remediation activities. This paper addresses why the unit was clean closed under an approved RCRA Closure Plan. Integration of EPA regulations for RCRA and CERCLA programs and the DOE-Orders impacting design, construction and operation of an acid neutralization system is also reviewed. The paper concludes with a discussion of lessons learned in the process in preparing the closure plant and through final project close out.

  13. Resource Conservation and Recovery Act (RCRA) contingency plan for hazardous waste treatment, storage, and disposal units at the Oak Ridge Y-12 Plant

    SciTech Connect

    Not Available

    1994-08-01

    The Y-12 RCRA Contingency Plan will be continually reviewed and revised if any of the following occur: the facility permit is revised, the plan is inadequate in an emergency, the procedures can be improved, the operations of the facility change in a way that alters the plan, the emergency coordinator changes, or the emergency equipment list changes. Copies of the Y-12 Emergency Management Plan are available at the Plant Shift Superintendent`s Office and the Emergency Management Office. This document serves to supplement the Y-12 Emergency Management Plan to be appropriate for all RCRA hazardous waste treatment, storage, or disposal units. The 90-day accumulation areas at the Y-12 Plant have a separate contingency supplement as required by RCRA and are separate from this supplement.

  14. Resource Conservation and Recovery Act (RCRA) general contingency plan for hazardous waste treatment, storage, and disposal units at the Oak Ridge Y-12 Plant

    SciTech Connect

    Skaggs, B.E.

    1993-11-01

    The Y-12 RCRA Contingency Plan will be continually reviewed and revised if any of the following occur: the facility permit is revised, the plan is inadequate in an emergency, the procedures herein can be improved, the operations of the facility change in a way that alters the plan, the emergency coordinator changes, or the emergency equipment list changes. Copies of the Y-12 Emergency Management Plan are available at the Plant Shift Superintendent`s Office and the Emergency Management Office. This document serves to supplement the Y-12 Emergency Management Plan to be appropriate for all RCRA hazardous waste treatment, storage, or disposal units. The 90-day accumulation areas at the Y-12 Plant have a separate contingency supplement as required by RCRA and are separate from this supplement.

  15. Evaluating the use of captive insurance as a financial assurance mechanism under RCRA

    SciTech Connect

    Finney, J.R.; Chan, E.K.; Clark, E.M.; Evans, M.L.; Johnson, M.F.

    1994-12-31

    This paper evaluates the use of insurance coverage underwritten by captive insurance companies to provide financial assurance for closure and post-closure care for facilities regulated under the Resource Conservation and Recovery Act of 1976 (RCRA). Regulations under RCRA subtitle C and subtitle D require that owners and operators of both hazardous waste treatment, storage, and disposal facilities (TSDF) and municipal solid waste landfills (MSWLF) demonstrate financial assurance for closure and post-closure care of such facilities. Those requirements help ensure that funds are available to cover the costs of closure and post-closure care, should the owner or operator be unable or unwilling to pay those costs. This paper provides a detailed analysis of how owners and operators use captive insurance companies to demonstrate financial assurance for closure and post-closure care under RCRA. The analysis explores, from a regulator`s point of view, the potential limitations of accepting captive insurance coverage as financial assurance for obligations for closure and post-closure care. The paper also provides: (1) an overview of captive insurance arrangements; (2) specific requirements for insurance for closure and post-closure care under RCRA; (3) state insurance regulations pertaining to the operations of captive insurance companies; and (4) recommendations that EPA and state agencies might consider to improve the current regulations and to ensure that funds will be available to pay for future environmental obligations.

  16. Resource conversation and recovery act (RCRA) Contingency Plan for interim status or permitted units at the Oak Ridge Y-12 Plant

    SciTech Connect

    Not Available

    1992-08-01

    The official mission of the Y-12 Plant is to serve as a manufacturing technology center for key processes such that capabilities are maintained for safe, secure, reliable, and survivable nuclear weapons systems and other applications of national importance. The Y-12 RCRA Contingency Plan will be reviewed and revised if necessary if the facility RCRA operating permits are revised, the plan is inadequate in an emergency, the procedures herein can be improved, the facility`s operations change in a manner that alters the plan, the emergency coordinator changes, or the emergency equipment list changes. Copies of the Y-12 Emergency Management Plan are available at the Plant Shift Superintendent`s Office and the Emergency Preparedness Office. This document serves to supplement the Y-12 Emergency Management Plan to be appropriate for all RCRA hazardous waste interim status or permitted treatment, storage, or disposal facilities. The 90-day storage areas at the Y-12 Plant have a separate contingency supplement as required by RCRA and are separate from this supplement.

  17. RCRA, Superfund and EPCRA hotline training module. Introduction to: Statutory overview of the Comprehensive Environmental Response, Compensation, and Liability Act (updated February 1998); Directive

    SciTech Connect

    1998-06-01

    This module presents a brief overview of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), the statute through which Congress established EPA`s hazardous substance release reporting and cleanup program, known as the Superfund program. This module presents information of the CERCLA statute only, not the regulations promulgated pursuant to the statute.

  18. Resource Conservation and Recovery Act (RCRA) Part B Permit Application for Production Associated Units at the Oak Ridge Y-12 Plant

    SciTech Connect

    Not Available

    1994-09-01

    This is the RCRA required permit application for Radioactive and Hazardous Waste Management at the Oak Ridge Y-12 Plant for the following units: Building 9206 Container Storage Unit; Building 9212 Container Storage Unit; Building 9720-12 Container Storage Unit; Cyanide Treatment Unit. All four of these units are associated with the recovery of enriched uranium and other metals from wastes generated during the processing of nuclear materials.

  19. The French Space Operation Act: Technical Regulations

    NASA Astrophysics Data System (ADS)

    Trinchero, J. P.; Lazare, B.

    2010-09-01

    The French Space Operation Act(FSOA) stipulates that a prime objective of the National technical regulations is to protect people, property, public health and the environment. Compliance with these technical regulations is mandatory as of 10 December 2010 for space operations by French space operators and for space operations from French territory. The space safety requirements and regulations governing procedures are based on national and international best practices and experience. A critical design review of the space system and procedures shall be carried out by the applicant, in order to verify compliance with the Technical Regulations. An independent technical assessment of the operation is delegated to CNES. The principles applied when drafting technical regulations are as follows: requirements must as far as possible establish the rules according to the objective to be obtained, rather than how it is to be achieved; requirements must give preference to international standards recognised as being the state of the art; requirements must take previous experience into account. Technical regulations are divided into three sections covering common requirements for the launch, control and return of a space object. A dedicated section will cover specific rules to be applied at the Guiana Space Centre. The main topics addressed by the technical regulations are: operator safety management system; study of risks to people, property, public health and the Earth’s environment; impact study on the outer space environment: space debris generated by the operation; planetary protection.

  20. Hanford Facility RCRA permit handbook

    SciTech Connect

    1996-03-01

    Purpose of this Hanford Facility (HF) RCRA Permit Handbook is to provide, in one document, information to be used for clarification of permit conditions and guidance for implementing the HF RCRA Permit.

  1. Implementing RCRA during facility deactivation

    SciTech Connect

    Lebaron, G.J.

    1997-09-07

    RCRA regulations require closure of permitted treatment, storage and disposal (TSD) facilities within 180 days after cessation of operations, and this may essentially necessitate decommissioning to complete closure. A more cost effective way to handle the facility would be to significantly reduce the risk to human health and the environment by taking it from its operational status to a passive, safe, inexpensive-to-maintain surveillance and maintenance condition (deactivation) prior to decommissioning. This paper presents an innovative approach to the cost effective deactivation of a large, complex chemical processing facility permitted under RCRA. The approach takes into account risks to the environment posed by this facility in comparison to risks posed by neighboring facilities at the site. The paper addresses the manner in which: 1) stakeholders and regulators were involved; 2) identifies a process by which the project proceeds and regulators and stakeholders were involved; 3) end points were developed so completion of deactivation was clearly identified at the beginning of the project, and 4) innovative practices were used to deactivate more quickly and cost effectively.

  2. RCRA groundwater monitoring data. Quarterly report, April 1, 1995--June 30, 1995

    SciTech Connect

    1995-10-01

    Nineteen Resource Conservation and Recovery Act of 1976 (RCRA) groundwater monitoring projects are conducted at the Hanford Site. These projects include treatment, storage, and disposal facilities for both solid and liquid waste. The groundwater monitoring programs described in this report comply with the interim-status federal (Title 40 Code of Federal Regulation [CFR] Part 265) and state (Washington Administrative Code [WAC] 173-303-400) regulations. The RCRA projects are monitored under one of three programs: background monitoring, indicator parameter evaluation, or groundwater quality assessment. Westinghouse Hanford Company (WHC) manages the RCRA groundwater monitoring projects on the Hanford Site. Performing project management, preparing groundwater monitoring plans, well network design and installation, specifying groundwater data needs, performing quality control (QC) oversight, data management, and preparing project sampling schedules are all parts of this responsibility. Pacific Northwest Laboratory (PNL) administers the contract for analytical services to WHC for the RCRA groundwater monitoring program. This quarterly report contains data received between April and June 1995, which are the cutoff dates for this reporting period. This report may contain not only data from the April through June quarter, but also data from earlier sampling events that were not previously reported.

  3. Issuance of final revised guidance on the use and issuance of administrative orders under Section 7003 of the Resource Conservation and Recovery Act (RCRA). Final report

    SciTech Connect

    Not Available

    1984-09-26

    The directive discusses guidance on the use and issuance of Administrative Orders under Section 7003 of RCRA where there is an emiminent and substantial endangerment to public health and the environment. In order to issue a Section 7003 order, the Administrator must possess evidence that the handling, storage, treatment, transportation or disposal of any solid waste or hazardous waste may present an imminent and substantial endangerment to health or the environment (42 U.S.C. Section 6973). Additionally, Section 7003 requires that the Administrator provide notice to the affected State prior to issuance of the order. Each of these requirements is discussed in the directive.

  4. NEPA/CERCLA/RCRA integration: Policy vs. practice

    SciTech Connect

    Hansen, R.P. ); Wolff, T.A. )

    1993-01-01

    Overwhelmed with environmental protection documentation requirements, a number of Federal agencies are grappling with the complexities of attempting to integrate'' the documentation requirements of the National Environmental Policy Act (NEPA), the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), and the Resource Conservation and Recovery Act (RCRA). While there is some overlap between the general environmental policy objectives of NEPA, and the much more specific waste cleanup objectives of CERCLA and RCRA, there are also major differences and outright conflicts. This paper identifies both problems and opportunities associated with implementing emerging and evolving Federal agency policy regarding integration of the procedural and documentation requirements of NEPA, CERCLA, and RCRA. The emphasis is on NEPA/CERCLA/RCRA integration policy and practice at US Department of Energy (DOE) facilities. The paper provides a comparative analysis of NEPA, CERCLA, and RCRA processes and discusses special integration issues including scoping, development and analysis of alternatives, risk assessment, tiering, scheduling, and the controversy surrounding applicability of NEPA to CERCLA or RCRA cleanup activities. Several NEPA/CERCLA/RCRA integration strategy options are evaluated and an annotated outline of an integrated NEPA/CERCLA document is included.

  5. The French Space Operations Act: Technical Regulations

    NASA Astrophysics Data System (ADS)

    Lazare, B.

    2013-12-01

    The French Space Operations Act (FSOA) [1] stipulates that one of the National Technical Regulations' prime objectives is to protect people, property, public health and the environment. Compliance with these Technical Regulations has been mandatory since 10 December, 2010 for space operations by French space operators and for space operations conducted on French territory. The space safety requirements and regulations governing procedures are based on national and international best practices and experience. A critical design review of the space system and procedures shall be carried out by applicant space operators, in order to verify compliance with the Technical Regulations. An independent technical assessment of the operation is delegated to CNES. The principles applied when drafting the Technical Regulations are as follows: requirements must, as far as possible, establish the rules according to the objective to be obtained, rather than how it is to be achieved; requirements must give preference to international standards recognised as being state of the art; requirements must take previous experience into account. The Technical Regulations are divided into three sections covering requirements common to the launch, control and return of a space object. A special section will cover specific rules to be applied at the Guiana Space Centre. The main topics addressed by the Technical Regulations are: operator safety management system; study of risks to people, property, public health and the Earth's environment; impact study on the outer space environment: space debris generated by the operation; planetary protection. The first version of the Technical Regulations [2], issued in March 2011, is dedicated to unmanned space systems.

  6. 78 FR 17176 - Federal Acquisition Regulation; Defense Base Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-20

    ... Federal Acquisition Regulation; Defense Base Act AGENCIES: Department of Defense (DoD), General Services... Act as extended by the Defense Base Act. DATES: Interested parties should submit written comments to... Act as extended by the Defense Base Act. II. Discussion and Analysis The Defense Base Act of...

  7. Selective removal/recovery of RCRA metals from waste and process solutions using polymer filtration{trademark} technology

    SciTech Connect

    Smith, B.F.

    1997-10-01

    Resource Conservation and Recovery Act (RCRA) metals are found in a number of process and waste streams at many DOE, U.S. Department of Defense, and industrial facilities. RCRA metals consist principally of chromium, mercury, cadmium, lead, and silver. Arsenic and selenium, which form oxyanions, are also considered RCRA elements. Discharge limits for each of these metals are based on toxicity and dictated by state and federal regulations (e.g., drinking water, RCRA, etc.). RCRA metals are used in many current operations, are generated in decontamination and decommissioning (D&D) operations, and are also present in old process wastes that require treatment and stabilization. These metals can exist in solutions, as part of sludges, or as contaminants on soils or solid surfaces, as individual metals or as mixtures with other metals, mixtures with radioactive metals such as actinides (defined as mixed waste), or as mixtures with a variety of inert metals such as calcium and sodium. The authors have successfully completed a preliminary proof-of-principle evaluation of Polymer Filtration{trademark} (PF) technology for the dissolution of metallic mercury and have also shown that they can remove and concentrate RCRA metals from dilute solutions for a variety of aqueous solution types using PF technology. Another application successfully demonstrated is the dilute metal removal of americium and plutonium from process streams. This application was used to remove the total alpha contamination to below 30 pCi/L for the wastewater treatment plant at TA-50 at Los Alamos National Laboratory (LANL) and from nitric acid distillate in the acid recovery process at TA-55, the Plutonium Facility at LANL (ESP-CP TTP AL16C322). This project will develop and optimize the PF technology for specific DOE process streams containing RCRA metals and coordinate it with the needs of the commercial sector to ensure that technology transfer occurs.

  8. Conducting RCRA inspections at mixed-waste facilities

    SciTech Connect

    Epstein, E.

    1991-07-01

    The document gives an overview of the regulation of radioactive mixed waste and provides RCRA inspectors with information on radiation, health physics, and training and access requirements for inspections of mixed waste facilities.

  9. Quarterly report of RCRA groundwater monitoring data for period January 1--March 31, 1995

    SciTech Connect

    1995-07-01

    This quarterly report contains data received between January and March 1995, which are the cutoff dates for this reporting period. This report may contain not only data from the January through March quarter, but also data from earlier sampling events that were not previously reported. Nineteen Resource Conservation and Recovery Act of 1976 (RCRA) groundwater monitoring projects are conducted at the Hanford Site. These projects include treatment, storage, and disposal facilities for both solid and liquid waste. The groundwater monitoring programs described in this report comply with the interim-status federal (Title 40 Code of Federal Regulation [CFR] Part 265) and state (Washington Administrative Code [WAC] 173-303-400) regulations. The RCRA projects are monitored under one of three programs: background monitoring, indicator parameter evaluation, or groundwater quality assessment.

  10. The mixture rule under the Resource Conservation and Recovery Act

    SciTech Connect

    Not Available

    1991-09-01

    Under the Resource Conservation and Recovery Act (RCRA), wastes may be classified as hazardous wastes or solid (non-hazardous) wastes. Each classification of wastes has its own applicable handling requirements. In accordance with the definition of hazardous waste under RCRA, waste mixtures containing a hazardous and solid waste component are hazardous wastes, unless certain exceptions apply. The primary purpose of the RCRA waste mixture provisions are to ensure that the Subtitle C (hazardous waste) requirements are applied consistently to both hazardous wastes and waste mixtures. These provisions were intended to discourage the commingling of the hazardous wastes with non-hazardous solid wastes simply to avoid Subtitle C regulation.

  11. Glossary of CERCLA, RCRA and TSCA related terms and acronyms. Environmental Guidance

    SciTech Connect

    Not Available

    1993-10-01

    This glossary contains CERCLA, RCRA and TSCA related terms that are most often encountered in the US Department of Energy (DOE) Environmental Restoration and Emergency Preparedness activities. Detailed definitions are included for key terms. The CERCLA definitions included in this glossary are taken from the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA), as amended and related federal rulemakings. The RCRA definitions included in this glossary are taken from the Resource Conservation and Recovery Act (RCRA) and related federal rulemakings. The TSCA definitions included in this glossary are taken from the Toxic Substances and Control Act (TSCA) and related federal rulemakings. Definitions related to TSCA are limited to those sections in the statute and regulations concerning PCBs and asbestos.Other sources for definitions include additional federal rulemakings, assorted guidance documents prepared by the US Environmental Protection Agency (EPA), guidance and informational documents prepared by the US Department of Energy (DOE), and DOE Orders. The source of each term is noted beside the term. Terms presented in this document reflect revised and new definitions published before July 1, 1993.

  12. 48 CFR 1480.102 - Buy Indian Act acquisition regulations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Buy Indian Act acquisition... INDIAN AFFAIRS SUPPLEMENT ACQUISITIONS UNDER THE BUY INDIAN ACT General 1480.102 Buy Indian Act... the Buy Indian Act. (b) This part is under the direct oversight and control of the Chief...

  13. Quarterly report of RCRA groundwater monitoring data for period July 1, 1991 through September 30, 1991

    SciTech Connect

    1991-12-01

    Hanford Site interim-status groundwater monitoring projects are conducted as either background, indicator parameter evaluation, or groundwater quality assessment monitoring programs as defined in the Resource Conservation and Recovery Act of 1976 (RCRA); and 40 CFR 265, Interim Status Standards for Owners and Operators of Hazardous Waste Treatment, Storage, and Disposal Facilities, as amended (EPA 1989). Compliance with the 40 CFR 265 regulations is required by the Washington Administrative Code (WAC) 173-303 (Ecology 1991). This submittal provides data obtained from groundwater monitoring activities for July 1, 1991 through September 30, 1991. This report contains groundwater monitoring data from Hanford Site groundwater projects. A RCRA network is currently being established at the 100-D Pond. Groundwater chemistry analyses have not yet been performed.

  14. Groundwater Monitoring Plan for the 1301-N, 1324-N/NA, and 1325-N RCRA Facilities

    SciTech Connect

    Hartman, Mary J.

    2002-06-08

    The 1301-N and 1325-N Liquid Waste Disposal Facilities, the 1324-N Surface Impoundment, and the 1324-NA Percolation Pond, located in the 100 N Area of the Hanford Site, are regulated under the Resource Conservation and Recovery Act of 1976 (RCRA). The closure plans for these facilities stipulate that groundwater is monitored according to the 100-N Pilot Project: Proposed Consolidated Groundwater Monitoring Program (BHI-00725). This document supplements the consolidated plan by providing information on sampling and analysis protocols, quality assurance, data management, and a conceptual model for the RCRA sites. Monitoring well networks, constituents, and sampling frequency remain the same as in the consolidated plan or the previous groundwater monitoring plan (Hartman 1996).

  15. Accelerating RCRA corrective action: The principles of the DOE approach

    SciTech Connect

    Kimmell, T.A.; Green, D.R.; Ranek, N.L.; Coalgate, J.L.

    1995-03-01

    The US Department of Energy (DOE) is involved in the remediation of environmental contamination at many of its facilities under the Resource Conservation and Recovery Act (RCRA). RCRA`s corrective action provisions were established by the Hazardous and Solid Waste Amendments of 1984 (HSWA). In response to the HSWA mandate, EPA established a program for the conduct of RCRA corrective action that was similar to that established under the Comprehensive Environmental Response Compensation and Liability Act (CERCLA). In addition, EPA developed and implemented its ``stabilization`` initiative as a means of quickly addressing immediate risks posed by releases until long term solutions can be applied. To improve the efficiency of environmental restoration at its facilities, DOE is developing guidance and training programs on accelerated environmental restoration under RCRA. A RCRA guidance document, entitled ``Accelerating RCRA Corrective Action at DOE Facilities,`` is currently being developed by DOE`s Office of Environmental Policy and Assistance. The new guidance document will outline a decision-making process for determining if acceleration is appropriate for individual facilities, for identifying, evaluating, and selecting options for program acceleration, and for implementing selected acceleration options. The document will also discuss management and planning strategies that provide a firm foundation for accelerating RCRA corrective action. These strategies include a number of very basic principles that have proven effective at DOE and other federal facilities, as well as some new approaches. The purpose of this paper is to introduce DOE`s new guidance document, discuss the general approach presented in the guidance for accelerating RCRA corrective action, and to emphasize some of the more important principles of effective management and planning.

  16. SALTSTONE BATCH 0 TCLP RCRA METAL RESULTS

    SciTech Connect

    Cozzi, A

    2007-06-14

    A saltstone waste form was prepared in the Savannah River National Laboratory from a Tank 50H sample and Z-Area premix material. After the prescribed 28 day cure, samples of the saltstone were collected, and the waste form was shown to meet the South Carolina Hazardous Waste Management Regulations (SCHWMR) R.61-79.261.24 requirements for a nonhazardous waste form with respect to RCRA metals. These analyses met all quality assurance specifications of USEPA SW-846.

  17. SACM and the RCRA stabilization initiative: Similarities of principles and applicability

    SciTech Connect

    1996-01-01

    The Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and the corrective action provisions of the Resource Conservation and Recovery Act (RCRA) provide standards for the remediation of environmental media contaminated with hazardous substances or hazardous waste, respectively. In both cases, prior to the US Environmental Protection Agency`s (EPA) development of the two subject reform initiatives, existing formal processes specified the level of site investigation required, the process for reaching a decision on the method of remediation, public participation in the decision process, and enforcement authorities that include orders and schedules of compliance. Traditionally, implementation of these processes has resulted in a great amount of time, effort, and money being expended before actual remediation began. Following criticism from the public and the regulated community, the EPA has proposed streamlining reforms for hazardous waste site cleanup under both CERCLA and RCRA that will begin remediation sooner with lower costs. The purpose of this Information Brief is to discuss the common goals, processes, and strategies of the Superfund Accelerated Cleanup Model (SACM) and the RCRA Stabilization Initiative.

  18. NASA Principal Center for Review of Clean Air Act Regulations

    NASA Technical Reports Server (NTRS)

    Clark-Ingram, Marceia; Munafo, Paul M. (Technical Monitor)

    2002-01-01

    The Clean Air Act (CAA) regulations have greatly impacted materials and processes utilized in the manufacture of aerospace hardware. Code JE/ NASA's Environmental Management Division at NASA Headquarters recognized the need for a formal, Agency-wide review process of CAA regulations. Marshall Space Flight Center (MSFC) was selected as the 'Principal Center for Review of Clean Air Act Regulations'. This presentation describes the centralized support provided by MSFC for the management and leadership of NASA's CAA regulation review process.

  19. Quarterly report of RCRA groundwater monitoring data for period October 1, 1993--December 31, 1993

    SciTech Connect

    Jungers, D.K.

    1994-04-01

    Hanford Site interim-status groundwater monitoring projects are conducted as either background, indicator parameter evaluation, or groundwater quality assessment monitoring programs as defined in the Resource Conservation and Recovery Act of 1976 (RCRA); and Interim Status Standards for Owners and Operators of Hazardous Waste Treatment, Storage, and Disposal Facilities, as amended (40 Code of Federal Regulations [CFR] 265). Compliance with the 40 CFR 265 regulations is required by the Washington Administrative Code (WAC) 173-303. This report contains data from Hanford Site groundwater monitoring projects. Westinghouse Hanford Company (WHC) manages the RCRA groundwater monitoring projects for federal facilities on the Hanford Site. Project management, specifying data needs, performing quality control (QC) oversight, managing data, and preparing project sampling schedules are all parts of this responsibility. Pacific Northwest Laboratory (PNL) administers the contract for analytical services and provides groundwater sampling services to WHC for the RCRA groundwater monitoring program. This quarterly report contains data received between November 20 and February 25, 1994, which are the cutoff dates for this reporting period. This report may contain not only data from the October through December quarter but also data from earlier sampling events that were not previously reported.

  20. Quarterly report of RCRA groundwater monitoring data for period October 1 through December 31, 1994

    SciTech Connect

    1995-04-01

    Hanford Site interim-status groundwater monitoring projects are conducted as either background, indicator parameter evaluation, or groundwater quality assessment monitoring programs as defined in the Resource Conservation and Recovery Act of 1976 (RCRA); and {open_quotes}Interim Status Standards for Owners and Operators of Hazardous Waste Treatment, Storage, and Disposal Facilities{close_quotes} (Title 40 Code of Federal Regulations [CFR] Part 265), as amended. Compliance with the 40 CFR 265 regulations is required by the Washington Administrative Code (WAC) 173-303. This report contains data from Hanford Site groundwater monitoring projects. The location of each facility is shown. Westinghouse Hanford Company (WHC) manages the RCRA groundwater monitoring projects for federal facilities on the Hanford Site. Performing project management, preparing groundwater monitoring plans, well network design and installation, specifying groundwater data needs, performing quality control (QC) oversight, data management, and preparing project sampling schedules are all parts of this responsibility. Pacific Northwest Laboratory (PNL) administers the contract for analytical services and provides groundwater sampling services to WHC for the RCRA groundwater monitoring program. This quarterly report contains data received between October and December 1994, which are the cutoff dates for this reporting period. This report may contain not only data from the October through December quarter, but also data from earlier sampling events that were not previously reported.

  1. 48 CFR 1480.102 - Buy Indian Act acquisition regulations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Buy Indian Act acquisition... INDIAN AFFAIRS SUPPLEMENT ACQUISITIONS UNDER THE BUY INDIAN ACT Subpart 1480.1 General 1480.102 Buy... in implementing the Buy Indian Act. (b) This part is under the direct oversight and control of...

  2. 13 CFR 108.30 - Amendments to Act and regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Amendments to Act and regulations. 108.30 Section 108.30 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION NEW MARKETS VENTURE CAPITAL (âNMVCâ) PROGRAM Introduction to Part 108 § 108.30 Amendments to Act and regulations. A...

  3. 13 CFR 107.30 - Amendments to Act and regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Amendments to Act and regulations. 107.30 Section 107.30 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS INVESTMENT COMPANIES Introduction to Part 107 § 107.30 Amendments to Act and regulations. A Licensee shall...

  4. HWMA/RCRA Closure Plan for the CPP-602 Laboratory Lines

    SciTech Connect

    Idaho Cleanup Project

    2009-09-30

    This Hazardous Waste Management Act/Resource Conservation and Recovery Act Closure (HWMA/RCRA) Plan for the CPP-602 laboratory lines was developed to meet the tank system closure requirements of the Idaho Administrative Procedures Act 58.01.05.008 and 40 Code of Federal Regulations 264, Subpart G. CPP-602 is located at the Idaho Nuclear Technology and Engineering Center at the Idaho National Laboratory Site. The lines in CPP-602 were part of a liquid hazardous waste collection system included in the Idaho Nuclear Technology and Engineering Center Liquid Waste Management System Permit. The laboratory lines discharged to the Deep Tanks System in CPP-601 that is currently being closed under a separate closure plan. This closure plan presents the closure performance standards and the methods for achieving those standards. The closure approach for the CPP-602 laboratory lines is to remove the lines, components, and contaminants to the extent practicable. Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) Site CPP-117 includes the CPP-602 waste trench and the area beneath the basement floor where waste lines are direct-buried. Upon completion of rinsing or mopping to remove contamination to the extent practicable from the waste trench and rinsing the intact buried lines (i.e., stainless steel sections), these areas will be managed as part of CERCLA Site CPP-117 and will not be subject to further HWMA/RCRA closure activities. The CPP-602 building is being decontaminated and decommissioned under CERCLA as a non-time critical removal action in accordance with the Federal Facility Agreement/Consent Order. As such, all waste generated by this CERCLA action, including closure-generated waste, will be managed in coordination with that CERCLA action in substantive compliance with HWMA/RCRA regulations. All waste will be subject to a hazardous waste determination for the purpose of supporting appropriate management and will be managed in accordance

  5. 77 FR 75521 - Community Reinvestment Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-21

    ... 1, 2005. 70 FR 44256 (Aug. 2, 2005). As explained in the SUPPLEMENTARY INFORMATION section of these... Home Mortgage Disclosure Act (HMDA). 70 FR 12148 (Mar. 11, 2005). See 12 U.S.C. 2808; 12 CFR 203.2(e)(1... the other federal banking agencies in its CRA rule set forth at 12 CFR part 563e. 72 FR 13429 (Mar....

  6. 75 FR 36270 - Appraisal Subcommittee; Appraiser Regulation; Privacy Act Implementation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-25

    ... INSTITUTIONS EXAMINATION COUNCIL 12 CFR Part 1102 Appraisal Subcommittee; Appraiser Regulation; Privacy Act... (October 1998). List of Subjects in 12 CFR Part 1102 Administrative practice and procedure, Banks, banking... of the Code of Federal Regulations is amended as follows: PART 1102--APPRAISER REGULATION Subpart...

  7. 78 FR 79283 - Community Reinvestment Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... CRA purposes by the OCC, Board, and FDIC on August 2, 2005, effective September 1, 2005. 70 FR 44256... Act (HMDA). 70 FR 12148 (Mar. 11, 2005). See 12 U.S.C. 2808; 12 CFR 203.2(e)(1). On March 22, 2007... other federal banking agencies in its CRA rule previously set forth at 12 CFR 563e. 72 FR 13429 (Mar....

  8. 76 FR 79529 - Community Reinvestment Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-22

    ... adopted for CRA purposes by the OCC, Board, and FDIC on August 2, 2005, effective September 1, 2005. 70 FR... Disclosure Act (HMDA). 70 FR 12148 (Mar. 22, 2007). See 12 U.S.C. 2808; 12 CFR 203.2(e)(1). On March 22, 2007... federal banking agencies in its CRA rule set forth at 12 CFR 563e. 72 FR 13429. Pursuant to the...

  9. RCRA, superfund and EPCRA hotline training module. Introduction to: RCRA enforcement and compliance updated July 1996

    SciTech Connect

    1996-07-01

    The module describes enforcement procedures and cites the statutory authority and describes the two different types of enforcement (i.e., administrative and judicial). It explains when and how EPA can enforce the RCRA regulations in authorized states. It describes the enforcement mechanisms available to EPA. It states the differences between enforcement at interim status and permitted facilities. It describes enforcement at federal facilities and identifies relevant resource documents.

  10. Hazardous waste enforcement. [RCRA and Superfund regulatory programs

    SciTech Connect

    Not Available

    1982-07-01

    A change is taking place in the enforcement of the Resource Conservation and Recovery Act (RCRA) and Superfund, a change described by the terms ''environmental results'' and ''cooperation, no confrontation''. Examples are given of environmental results achieved through criminal enforcement. In June 1981, a New York businessman received a two and one-half year prison sentence for dumping PCB-laced oil along North Carolina roads; a second defendant received an 18-month jail term. Other important measures of environmental results achieved by enforcement are 1) commitment of private money and effort for hazardous waste management and 2) the number of facility inspections conducted under RCRA's regulatory program's compliance monitoring system. A new strategy of cooperation between U.S. EPA and the parties affected by RCRA and Superfund should change the pattern which produced the confrontational conflicts of the past. (JMT)

  11. 77 FR 75362 - Government in the Sunshine Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-20

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY COMMISSION 29 CFR Part 1612 Government in the Sunshine Act Regulations CFR Correction 0 In Title 29 of the Code of Federal Regulations, Parts 900 to 1899, revised as of July 1, 2012, on page 266, in Sec....

  12. Revised RCRA closure plan for the Interim Drum Yard (S-030) at the Oak Ridge Y-12 Plant, Oak Ridge, Tennessee

    SciTech Connect

    Smith, C.M.

    1994-09-01

    The Interim Drum Yard (IDY) facility is a containerized waste storage area located in the Y-12 exclusion area. It was used to store waste materials which are regulated by RCRA (Resource Conservation and Recovery Act); uranyl nitrate solutions were also stored there. The closure plan outlines the actions required to achieve closure of IDY and is being submitted in accordance with TN Rule 1200-1-11.05(7) and 40 CFR 265.110.

  13. National spent fuel program preliminary report RCRA characteristics of DOE-owned spent nuclear fuel DOE-SNF-REP-002. Revision 3

    SciTech Connect

    1995-07-01

    This report presents information on the preliminary process knowledge to be used in characterizing all Department of Energy (DOE)-owned Spent Nuclear Fuel (SNF) types that potentially exhibit a Resource Conservation and Recovery Act (RCRA) characteristic. This report also includes the process knowledge, analyses, and rationale used to preliminarily exclude certain SNF types from RCRA regulation under 40 CFR {section}261.4(a)(4), ``Identification and Listing of Hazardous Waste,`` as special nuclear and byproduct material. The evaluations and analyses detailed herein have been undertaken as a proactive approach. In the event that DOE-owned SNF is determined to be a RCRA solid waste, this report provides general direction for each site regarding further characterization efforts. The intent of this report is also to define the path forward to be taken for further evaluation of specific SNF types and a recommended position to be negotiated and established with regional and state regulators throughout the DOE Complex regarding the RCRA-related policy issues.

  14. Requirements for satellite accumulation areas. RCRA Information Brief

    SciTech Connect

    Powers, J.

    1993-07-01

    In 1980, EPA promulgated hazardous waste management regulations under the Resource Conservation and Recovery Act (RCRA), which included standard for generators of hazardous waste. With respect to storage of hazardous waste on-site by generators, these regulations originally made no distinction between the initial accumulation of hazardous waste at various points of generation (i.e., ``satellite`` accumulation) and storage at locations where hazardous waste is consolidated for on-site management or transportation off-site. EPA amended the hazardous waste generator regulations on December 20, 1984, to allow generators to store hazardous waste in satellite areas as long as certain conditions were met. State programs, however, do not have to allow for the accumulation of hazardous waste in satellite areas or may have more stringent requirements for these waste accumulation areas. A satellite accumulation area is a storage location at or near any point of generation where hazardous wastes initially accumulate, which is under the control of the operator of the process generating the waste. Wastes stored in these areas are subject to regulatory requirements that are less stringent than requirements applicable to hazardous wastes stored in permitted, interim status, or 90-day storage areas meeting the applicable provisions of 40 CFR 264, 265, or 262.34(a), respectively.

  15. Calendar Year 2002 RCRA & CERCLA Groundwater Monitoring Well summary report

    SciTech Connect

    MARTINEZ, C.R.

    2003-01-01

    This report describes the calendar year 2002 field activities associated with installing four new groundwater monitoring wells in the 200 West Area of the Hanford Site. Two groundwater monitoring wells are located around waste management area (WMA) TX-TY to support the ''Resource Conservation and Recovery Act of 1976'' (RCRA) and two groundwater monitoring wells are located in the 200-UP-1 and 200-ZP-1 operable units (OU) to support the ''Comprehensive Environmental Response, Compensation, and Liability Act of 1980'' (CERCLA).

  16. How landfill gas causes RCRA compliance problems

    SciTech Connect

    Kerfoot, H.B.

    1996-06-01

    The Resource Conservation and Recovery Act (RCRA) requires landfill operators to monitor groundwater at their facilities. This regulatory requirement is designed to prevent contamination that can result as rainfall drains through refuse, causing pollutants to leach into the groundwater. Several parameters commonly associated with leachate are monitored under RCRA as indicator parameters, or parameters that represent readily detected indicators of contamination. These parameters include volatile organic compounds (VOCs) and alkalinity. Because of its potentially high concentration of VOCs and non-volatile contaminants, landfill leachate represents the greatest threat to groundwater from solid waste facilities. However, other sources can elevate indicator parameters as well. Increasingly lower detection limits can be achieved for VOCs in groundwater, enabling detection of VOCs and carbon dioxide (CO{sub 2}) from landfill gas. In addition, CO{sub 2} from landfill gas can increase groundwater alkalinity. Releases of VOCs in landfill gas can be eliminated by minimizing the gas pressure within the landfill, either by installing a gas-collection system or upgrading an existing gas-collection system by adding wells or altering gas flow in portions of the system.

  17. Oil & gas exploration and production waste - RCRA exemptions and non-exempts

    SciTech Connect

    Dutta, S.; Alam, W.

    1995-12-01

    Petroleum industry generates substantial amounts of wastes that is related to exploration, drilling, production, and development activities. Management of these wastes is essential to ensure protection of human health and the environment and also to comply with the regulations that govern them. These regulation were 7. based mainly upon a study done by U.S. Environmental Protection Agency (EPA) on the impact of these wastes on environment while considering the economic impact of subjecting these wastes to the Resource Conservation and Recovery Act (RCRA), Subtitle C regulations. Based on this study, exemption is granted to petroleum wastes that results from exploration, drilling, production, and development activities. Under this exemption petroleum wastes are not considered hazardous wastes. To address the diverse environmental and programmatic issues posed by these petroleum wastes, EPA has taken a three-pronged approach: (1) Improving Federal programs under authorities in Subtitle D of RCRA, the Clean Water Act (CWA), and the Safe Drinking Water Act (SDWA); (2) Working with States to encourage changes in their regulations and enforcement to improve some programs; and (3) Working with congress to develop any additional statutory authorities that may be required. Confusion about the exempt and non-exempt status of wastes from the exploration and production (E & P) activities in the petroleum industry seem to be quite prevalent, especially in light of the State and local requirements being different in many cases. This paper is an attempt to clarify the exempt and non-exempt status of wastes and to provide a clear understanding of the regulations that the industry must abide by in order to comply with both State and Federal requirements. Acceptable methods of waste handling and management are also discussed in this paper which should help the industry in pollution prevention and resource conservation aspect of waste management.

  18. RCRA, superfund and EPCRA hotline training module. Introduction to: RCRA corrective action updated July 1996

    SciTech Connect

    1996-07-01

    The module discusses the regulatory and statutory requirements and authorities governing the Resource Conservation and Recovery Act (RCRA) corrective action process. There are minimal regulatory requirements at present, but the Agency has issued a proposed rule (55 FR 30798; July 27, 1990) that would establish a comprehensive regulatory framework for implementing the corrective action program. This proposed rule and other guidance developed pursuant to statutory authorities are used to structure corrective action requirements in facility permits and orders. This module describes the current statutory and regulatory structure and discusses the future of the proposed rule.

  19. State hazardous waste programs; procedures for revision of state RCRA programs--EPA. Proposed rule.

    PubMed

    1983-08-25

    EPA is today proposing to amend its requirements under 40 CFR 271.21(e) (formerly Section 123.13(e)) for the approval and revision of authorized state hazardous waste programs. One purpose is to ensure that states applying for final authorization under the Resource Conservation and Recovery Act of 1976, as amended, (RCRA) do not have to revise their programs and applications to respond to federal regulatory changes occurring while the states' applications are being prepared or processed. The second purpose is to provide all authorized states with one full year (or two years, if there is a need for state legislative action) from the effective date of amended federal regulations to make the revisions in their programs required by such federal amendments. This action would provide the state with an additional six months since the existing regulation requires that program revisions be made within one year (or two years) after the promulgation of amended federal regulations.

  20. 75 FR 41370 - Regulations Implementing the Freedom of Information Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-16

    ... amended. 75 FR 22320, Apr. 28, 2010. Interested persons were afforded an opportunity to participate in the... HEALTH REVIEW COMMISSION 29 CFR Part 2201 Regulations Implementing the Freedom of Information Act AGENCY: Occupational Safety and Health Review Commission. ACTION: Final rule. SUMMARY: The Occupational Safety...

  1. 76 FR 59071 - Freedom of Information Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-23

    ... follows: Authority: 50 U.S.C. 401-442; 50 U.S.C. 403a-403v; 5 U.S.C. 552; Executive Order 13392, 70 FR... From the Federal Register Online via the Government Publishing Office CENTRAL INTELLIGENCE AGENCY 32 CFR Part 1900 Freedom of Information Act Regulations AGENCY: Central Intelligence Agency....

  2. 76 FR 45403 - Bank Secrecy Act Regulations-Definitions and Other Regulations Relating to Prepaid Access

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-29

    ... regulations. See 75 FR 65806 (October 26, 2010) (Transfer and Reorganization of Bank Secrecy Act Regulations... Relating to Money Services Businesses, 74 FR 22129 (May 12, 2009), was issued before the Chapter X Final...), (c). \\16\\ 75 FR 36589. B. Prior Regulation of Stored Value In 1999, when FinCEN issued its final...

  3. NASA's Principal Center for Review of Clean Air Act Regulations

    NASA Technical Reports Server (NTRS)

    Clark-Ingram, Marceia

    2003-01-01

    Marshall Space Flight Center (MSFC) was selected as the Principal Center for review of Clean Air Act (CAA) regulations. The CAA Principal Center is tasked to: 1) Provide centralized support to NASA/HDQ Code JE for the management and leadership of NASA's CAA regulation review process; 2) Identify potential impact from proposed CAA regulations to NASA program hardware and supporting facilities. The Shuttle Environmental Assurance Initiative, one of the responsibilities of the NASA CAA Working Group (WG), is described in part of this viewgraph presentation.

  4. The WIPP RCRA Part B permit application for TRU mixed waste disposal

    SciTech Connect

    Johnson, J.E.; Snider, C.A.

    1995-12-31

    In August 1993, the New Mexico Environment Department (NMED) issued a draft permit for the Waste Isolation Pilot Plant (WIPP) to begin experiments with transuranic (TRU) mixed waste. Subsequently, the Department of Energy (DOE) decided to cancel the on-site test program, opting instead for laboratory testing. The Secretary of the NMED withdrew the draft permit in 1994, ordering the State`s Hazardous and Radioactive Waste Bureau to work with the DOE on submittal of a revised permit application. Revision 5 of the WIPP`s Resource Conservation and Recovery Act (RCRA) Part B Permit Application was submitted to the NMED in May 1995, focusing on disposal of 175,600 m{sup 3} of TRU mixed waste over a 25 year span plus ten years for closure. A key portion of the application, the Waste Analysis Plan, shifted from requirements to characterize a relatively small volume of TRU mixed waste for on-site experiments, to describing a complete program that would apply to all DOE TRU waste generating facilities and meet the appropriate RCRA regulations. Waste characterization will be conducted on a waste stream basis, fitting into three broad categories: (1) homogeneous solids, (2) soil/gravel, and (3) debris wastes. Techniques used include radiography, visually examining waste from opened containers, radioassay, headspace gas sampling, physical sampling and analysis of homogeneous wastes, and review of documented acceptable knowledge. Acceptable knowledge of the original organics and metals used, and the operations that generated these waste streams is sufficient in most cases to determine if the waste has toxicity characteristics, hazardous constituents, polychlorinated biphenyls (PBCs), or RCRA regulated metals.

  5. Impact of the resource conservation and recovery act on energy facility siting

    SciTech Connect

    Tevepaugh, C.W.

    1982-01-01

    The Resource Conservation and Recovery Act (RCRA) of 1976 is a multifaceted approach to the management of both solid and hazardous waste. The focus of this research is on the RCRA mandated proposed regulations for the siting of hazardous waste disposal facilities. This research is an analysis of the interactions among hazardous waste disposal facilities, energy supply technologies and land use issues. This study addresses the impact of RCRA hazardous waste regulations in a descriptive and exploratory manner. A literature and legislative review, interviews and letters of inquiry were synthesized to identify the relationship between RCRA hazardous waste regulations and the siting of selected energy supply technologies. The results of this synthesis were used to determine if and how RCRA influences national land use issues. It was found that the interaction between RCRA and the siting of hazardous waste disposal facilities required by energy supply technologies will impact national land use issues. All energy supply technologies reviewed generate hazardous waste. The siting of industrial functions such as energy supply facilities and hazardous waste disposal facilities will influence future development patterns. The micro-level impacts from the siting of hazardous waste disposal facilities will produce a ripple effect on land use with successive buffer zones developing around the facilities due to the interactive growth of the land use sectors.

  6. New hazardous waste management system: regulation of wastes or wasted regulation

    SciTech Connect

    Friedland, S.I.

    1981-01-01

    The unsound management of hazardous wastes, as exemplified by Love Canal, causes a variety of environmental and health problems. A review of present state controls reveals the need for the Federal regulation that was incorporated in the Resource Conservation and Recovery Act of 1976 (RCRA). A detailed description of RCRA, however, faults the Environmental Protection Agency (EPA) for deferring regulation and for its failure to meet deadlines, issue standards, or include many dangerous wastes in the prohibited list. EPA's interim standards of essentially voluntary guidelines will offer little protection from contamination until final permit regulations are established. 326 references. (DCK)

  7. Medical loss ratio regulation under the Affordable Care Act.

    PubMed

    Harrington, Scott E

    2013-01-01

    The minimum medical loss ratio (MLR) regulations in the Affordable Care Act guarantee that a specific percentage of health insurance premiums is spent on medical care and specified activities to improve health care quality. This paper analyzes the regulations' potential unintended consequences and incentive effects, including: higher medical costs and premiums for some insurers; less innovation to align consumer, provider, and health plan incentives, less consumer choice and increased market concentration; and the risk that insurers will pay rebates if claim costs are lower than projected when premiums are established, despite the regulations' permitted "credibility adjustments." The paper discusses modifications and alternatives to the MLR regulations to help achieve their stated goals with less potential for adverse effects. PMID:23720876

  8. 77 FR 74347 - Freedom of Information Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-14

    ... Information Act (FOIA) (U.S.C. 552) in the Federal Register. See 77 FR 42673, July 20, 2012. CIGIE provided..., Regulatory Planning and Review, 58 FR 51735. This regulation has not been reviewed by the Office of.... Authority: Pub. L. 110-409, 122 Stat. 4302; 5 U.S.C. App; E.O. 12600, 52 FR 23781, 3 CFR, 1987 Comp., p....

  9. Quarterly report of RCRA groundwater monitoring data for period January 1, 1993 through March 31, 1993

    SciTech Connect

    Not Available

    1993-07-01

    Hanford Site interim-status groundwater monitoring projects are conducted as either background, indicator parameter evaluation, or groundwater quality assessment monitoring programs as defined in the Resource Conservation and Recovery Act of 1976 (RCRA); and Interim Status Standards for Owners and Operators of Hazardous Waste Treatment, Storage, and Disposal Facilities, as amended (40 Code of Federal Regulations [CFR] 265). Compliance with the 40 CFR 265 regulations is required by the Washington Administrative Code (WAC) 173-303. This report contains data from Hanford Site groundwater monitoring projects. This quarterly report contains data received between March 8 and May 24, 1993, which are the cutoff dates for this reporting period. This report may contain not only data from the January through March quarter but also data from earlier sampling events that were not previously reported.

  10. 76 FR 35963 - Disclosure of Information; Privacy Act Regulations; Notice and Amendments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-21

    ... CORPORATION 12 CFR Parts 309 and 310 RIN 3064-AD83 Disclosure of Information; Privacy Act Regulations; Notice... for comments. SUMMARY: The Dodd-Frank Wall Street Reform and Consumer Protection Act (Act), abolished... Freedom of Information Act (FOIA) and Privacy Act (PA) regulations will not be enforced by the FDIC...

  11. RCRA corrective action: Statement of basis and response to comments decision documents

    SciTech Connect

    1994-07-01

    Under the Resource Conservation and Recovery Act (RCRA), Statement of Basis (SB) and Response to Comments (RTC) decision documents are prepared when a corrective action is implemented through either a permit or enforcement order [RCRA {section} 3008(h)]. EPA`s Guidance on RCRA Corrective Action Decision Documents presents a standard format for documenting RCRA corrective action decisions. The guidance clarifies the roles and responsibilities of regulatory agencies in developing and issuing decision documents. DOE, for some corrective actions, may be directed to prepare materials for the Statement of Basis. EPA`s guidance is intended to provide consistency in the organization and content of decision documents as well as promote clear and logical presentations of rationales for remedy selection decisions based on facility-specific information and supporting analysis. This Information Brief summarizes EPA`s guidance on SB and RTC decision documents.

  12. RCRA Assessment Plan for Single-Shell Tank Waste Management Area TX-TY

    SciTech Connect

    Horton, Duane G.

    2007-03-26

    WMA TX-TY contains underground, single-shell tanks that were used to store liquid waste that contained chemicals and radionuclides. Most of the liquid has been removed, and the remaining waste is regulated under the RCRA as modi¬fied in 40 CFR Part 265, Subpart F and Washington State’s Hazardous Waste Management Act . WMA TX-TY was placed in assessment monitoring in 1993 because of elevated specific conductance. A groundwater quality assessment plan was written in 1993 describing the monitoring activities to be used in deciding whether WMA TX-TY had affected groundwater. That plan was updated in 2001 for continued RCRA groundwater quality assessment as required by 40 CFR 265.93 (d)(7). This document further updates the assessment plan for WMA TX-TY by including (1) information obtained from ten new wells installed at the WMA after 1999 and (2) information from routine quarterly groundwater monitoring during the last five years. Also, this plan describes activities for continuing the groundwater assessment at WMA TX TY.

  13. RCRA Groundwater Monitoring Plan for Single-Shell Tank Waste Management Area C at the Hanford Site

    SciTech Connect

    Horton, Duane G.; Narbutovskih, Susan M.

    2001-01-01

    This document describes the groundwater monitoring plan for Waste Management Area C located in the 200 East Area of the DOE Hanford Site. This plan is required under Resource Conservation and Recovery Act of 1976 (RCRA).

  14. Groundwater Monitoring Plan for the Hanford Site 216-B-3 Pond RCRA Facility

    SciTech Connect

    Barnett, D BRENT.; Smith, Ronald M.; Chou, Charissa J.; McDonald, John P.

    2005-11-01

    The 216-B-3 Pond system was a series of ponds used for disposal of liquid effluent from past Hanford production facilities. In operation from 1945 to 1997, the B Pond System has been a Resource Conservation and Recovery Act (RCRA) facility since 1986, with RCRA interim-status groundwater monitoring in place since 1988. In 1994 the expansion ponds of the facility were clean closed, leaving only the main pond and a portion of the 216-B-3-3 ditch as the currently regulated facility. In 2001, the Washington State Department of Ecology (Ecology) issued a letter providing guidance for a two-year, trial evaluation of an alternate, intrawell statistical approach to contaminant detection monitoring at the B Pond system. This temporary variance was allowed because the standard indicator-parameters evaluation (pH, specific conductance, total organic carbon, and total organic halides) and accompanying interim status statistical approach is ineffective for detecting potential B-Pond-derived contaminants in groundwater, primarily because this method fails to account for variability in the background data and because B Pond leachate is not expected to affect the indicator parameters. In July 2003, the final samples were collected for the two-year variance period. An evaluation of the results of the alternate statistical approach is currently in progress. While Ecology evaluates the efficacy of the alternate approach (and/or until B Pond is incorporated into the Hanford Facility RCRA Permit), the B Pond system will return to contamination-indicator detection monitoring. Total organic carbon and total organic halides were added to the constituent list beginning with the January 2004 samples. Under this plan, the following wells will be monitored for B Pond: 699-42-42B, 699-43-44, 699-43-45, and 699-44-39B. The wells will be sampled semi-annually for the contamination indicator parameters (pH, specific conductance, total organic carbon, and total organic halides) and annually for

  15. RCRA/UST, superfund, and EPCRA hotline training module. Introduction to: RCRA enforcement and compliance, update as of July 1995

    SciTech Connect

    1995-11-01

    The module describds enforcement procedures and cites the statutory authority. It describes the two different types of enforcement (i.e., administrative and judicial) and explains when and how EPA can enforce the RCRA regulations in authorized states. It describes the enforcement mechanisms available to EPA. It states the differences between enforcement at interim status, permitted facilities, and Federal facilities. It also identifies relevant resources documents.

  16. Safe drinking water act: Amendments, regulations and standards

    SciTech Connect

    Calabrese, E.J.; Gilbert, C.E.; Pastides, H.

    1989-01-01

    This book approaches the topic of safe drinking water by communicating how the EPA has responded to the mandates of Congress. Chapter 1 summarizes what is and will be involved in achieving safe drinking water. Chapter 2 describes the historical development of drinking water regulations. Chapter 3 summarizes the directives of the Safe Drinking Water Act Amendments of 1986. Chapters 4 through 9 discuss each phase of the regulatory program in turn. Specific problems associated with volatile organic chemicals, synthetic organics, inorganic chemicals, and microbiological contaminants are assessed in Chapter 4 and 5. The unique characteristics of radionuclides and their regulation are treated in Chapter 6. The disinfection process and its resultant disinfection by-products are presented in Chapter 7. The contaminant selection process and the additional contaminants to be regulated by 1989 and 1991 and in future years are discussed in Chapters 8 and 9. EPA's Office of Drinking Water's Health Advisory Program is explained in Chapter 10. The record of public water system compliance with the primary drinking water regulations is detailed in Chapter 11. Chapter 12 offers a nongovernmental perspective on the general quality of drinking water and how this is affected by a wide range of drinking water treatment technologies. Separate abstracts are processed for 5 chapters in this book for inclusion in the appropriate data bases.

  17. 7 CFR 800.7 - Information about the Service, Act, and regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Information about the Service, Act, and regulations... AGRICULTURE GENERAL REGULATIONS Administration § 800.7 Information about the Service, Act, and regulations. Information about the Grain Inspection, Packers and Stockyards Administration, Service, Act,...

  18. Interim-Status RCRA Groundwater Monitoring Plan for the 216-A-10, 216-A-36B, and 216-A-37-1 PUREX Cribs

    SciTech Connect

    Lindberg, Jon W.; Elmore, Rebecca P.

    2005-07-21

    This document presents a groundwater monitoring program for three Resource Conservation and Recovery Act of 1976 (RCRA) waste management units at the Hanford Site combined under one groundwater quality assessment program. The units are the 216 A 10, 216 A 36B, and 216 A-37-1 cribs (the RCRA PUREX cribs). The three cribs have been grouped together based on their proximity to one another, similar construction and waste history, and similar hydrogeologic regime. The RCRA PUREX cribs are located in the 200 East Area of the Hanford Site. This document replaces the previous RCRA monitoring plan (Lindberg 1997-PNNL-11523, Rev.0) for these cribs.

  19. Regulations Under the Americans With Disabilities Act; Genetic Information Nondiscrimination Act. Final rule.

    PubMed

    2016-05-17

    The Equal Employment Opportunity Commission (EEOC or Commission) is issuing its final rule to amend the regulations and interpretive guidance implementing Title I of the Americans with Disabilities Act (ADA) to provide guidance on the extent to which employers may use incentives to encourage employees to participate in wellness programs that ask them to respond to disability-related inquiries and/or undergo medical examinations. This rule applies to all wellness programs that include disability-related inquiries and/or medical examinations whether they are offered only to employees enrolled in an employer-sponsored group health plan, offered to all employees regardless of whether they are enrolled in such a plan, or offered as a benefit of employment by employers that do not sponsor a group health plan or group health insurance. Published elsewhere in this issue of the Federal Register, the EEOC also issued a final rule to amend the regulations implementing Title II of the Genetic Information Nondiscrimination Act (GINA) that addresses the extent to which employers may offer incentives for an employee's spouse to participate in a wellness program. PMID:27192736

  20. Regulations Under the Americans With Disabilities Act; Genetic Information Nondiscrimination Act. Final rule.

    PubMed

    2016-05-17

    The Equal Employment Opportunity Commission (EEOC or Commission) is issuing its final rule to amend the regulations and interpretive guidance implementing Title I of the Americans with Disabilities Act (ADA) to provide guidance on the extent to which employers may use incentives to encourage employees to participate in wellness programs that ask them to respond to disability-related inquiries and/or undergo medical examinations. This rule applies to all wellness programs that include disability-related inquiries and/or medical examinations whether they are offered only to employees enrolled in an employer-sponsored group health plan, offered to all employees regardless of whether they are enrolled in such a plan, or offered as a benefit of employment by employers that do not sponsor a group health plan or group health insurance. Published elsewhere in this issue of the Federal Register, the EEOC also issued a final rule to amend the regulations implementing Title II of the Genetic Information Nondiscrimination Act (GINA) that addresses the extent to which employers may offer incentives for an employee's spouse to participate in a wellness program.

  1. Adaptive Equilibrium Regulation: A Balancing Act in Two Timescales

    PubMed Central

    Boker, Steven M.

    2015-01-01

    An equilibrium involves a balancing of forces. Just as one maintains upright posture in standing or walking, many self-regulatory and interpersonal behaviors can be framed as a balancing act between an ever changing environment and within-person processes. The emerging balance between person and environment, the equilibria, are dynamic and adaptive in response to development and learning. A distinction is made between equilibrium achieved solely due to a short timescale balancing of forces and a longer timescale preferred equilibrium which we define as a state towards which the system slowly adapts. Together, these are developed into a framework that this article calls Adaptive Equilibrium Regulation (ÆR), which separates a regulatory process into two timescales: a faster regulation that automatically balances forces and a slower timescale adaptation process that reconfigures the fast regulation so as to move the system towards its preferred equilibrium when an environmental force persists over the longer timescale. This way of thinking leads to novel models for the interplay between multiple timescales of behavior, learning, and development. PMID:27066197

  2. RCRA, superfund and EPCRA hotline training module. Introduction to: RCRA treatment, storage, and disposal facilities (40 cfr parts 264/265, subparts a-e) updated July 1996

    SciTech Connect

    1996-07-01

    The management of hazardous waste at treatment, storage, and disposal facilities (TSDFs) plays a large and critical role in the Resource Conservation and Recovery Act (RCRA) regulatory scheme. The training module presents an overview of the general TSDF standards found in 40 CFR Parts 264/265, Subparts A through E.

  3. 77 FR 43081 - Federal Acquisition Regulation; Information Collection; Buy American Act-Free Trade Agreements...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    ... Regulation; Information Collection; Buy American Act--Free Trade Agreements--Israeli Trade Act Certificate... previously approved information collection requirement concerning the Buy American Act--Free Trade Agreements..., Buy American Act--Free Trade Agreements--Israeli Trade Act Certificate, by any of the...

  4. RCRA delisting of agent-decontaminated waste at Dugway Proving Ground

    SciTech Connect

    Kimmell, T.A.; Anderson, A.W.; Green, D.R.; Lopez, J.D.

    1995-04-01

    The State of Utah has declared residues resulting from the demilitarization, treatment, cleanup, testing of military chemical agents to be hazardous wastes. These residues are listed as hazardous waste in Utah and several other States, but are not listed under regulations established by the US Environmental Protection Agency (EPA) pursuant to the Federal Resource Conservation and Recovery Act (RCRA), the primary law governing management of hazardous waste in the US These residues are identified as hazardous waste due to corrosivity, reactivity, chronic toxicity, and acute toxicity, and are designated as Hazardous Waste No. F999. The RCRA regulations (40 CFR 260-280), the Utah Administrative Code (R-315), and other State hazardous waste programs list specific wastes as hazardous, but allow generators to petition the regulator to ``delist`` if it can be demonstrated that such wastes are not hazardous. The US Army Test and Evaluation Command (TECOM) has initiated a project with the Argonne National Laboratory to demonstrate that certain categories of F999 residues are not hazardous waste and to achieve delisting. The initial focus is on delisting specific residues from decontamination of wastes generated during materials testing activities and contaminated soil at the US Army Dugway Proving Ground (DPG), Utah. This activity is referred to as Phase I of the delisting program. Subsequent phases of the delisting program will address additional waste streams at DPG and other Army installations. The purpose of this paper is to outline the Phase I TECOM delisting effort at DPG, identify some of the important technical issues associated with the delisting, and to discuss overall progress to date.

  5. Financial responsibilities under RCRA. Hearing before the Subcommittee on Commerce, Transportation, and Tourism of the Committee on Energy and Commerce, House of Representatives, Ninety-Ninth Congress, First Session on H. R. 3692, November 13, 1985

    SciTech Connect

    Not Available

    1986-01-01

    Representatives of environmental organizations, the Hazardous Waste Treatment Council, and regulators were among those testifying at a hearing on H.R. 3692, which amends the Resource Conservation and Recovery Act (RCRA) of 1976. The bill is in response to concerns that the Environmental Protection Agency (EPA) has not compiled with the intent of RCRA in its failure to move beyond interim permits to issue final permits to land disposal facilities accepting hazardous wastes. Reported leakage and environmental risks from sites operating under interim permits raises questions about how disposal companies could deal with liability claims. At issue was whether Congress needs to take new action to develop regulations under which financially responsible companies can operate or whether new EPA rules can solve the problem. A spokesman for EPA reviewed the liability insurance problem and the status of the insurance market in this context. Material submitted for the record follows the text of H.R. 3692 and the testimony of 11 witnesses.

  6. RCRA toxicity characterization of discarded electronic devices.

    PubMed

    Musson, Stephen E; Vann, Kevin N; Jang, Yong-Chul; Mutha, Sarvesh; Jordan, Aaron; Pearson, Brian; Townsend, Timothy G

    2006-04-15

    The potential for discarded electronic devices to be classified as toxicity characteristic (TC) hazardous waste under provisions of the Resource Conservation and Recovery Act (RCRA) using the toxicity characteristic leaching procedure (TCLP) was examined. The regulatory TCLP method and two modified TCLP methods (in which devices were disassembled and leached in or near entirety) were utilized. Lead was the only element found to leach at concentrations greater than its TC limit (5 mg/L). Thirteen different types of electronic devices were tested using either the standard TCLP or modified versions. Every device type leached lead above 5 mg/L in at least one test and most devices leached lead above the TC limit in a majority of cases. Smaller devices that contained larger amounts of plastic and smaller amounts of ferrous metal (e.g., cellular phones, remote controls) tended to leach lead above the TC limit at a greater frequency than devices with more ferrous metal (e.g., computer CPUs, printers).

  7. SEMINAR PROCEEDINGS: RCRA CORRECTIVE ACTION STABILIZATION TECHNOLOGIES

    EPA Science Inventory

    The seminar publication provides an overview of many technologies that can be used in applying the stabilization concept to RCRA cleanup activities. Technologies discussed include covers, grouting, slurry walls, hydrofracture, horizontal well drilling, a vacuum extraction, and b...

  8. RCRA Facilities Assessment (RFA)---Oak Ridge National Laboratory

    SciTech Connect

    Not Available

    1987-03-01

    US Department of Energy (DOE) facilities are required to be in full compliance with all federal and state regulations. In response to this requirement, the Oak Ridge National Laboratory (ORNL) has established a Remedial Action Program (RAP) to provide comprehensive management of areas where past and current research, development, and waste management activities have resulted in residual contamination of facilities or the environment. This report presents the RCRA Facility Assessment (RFA) required to meet the requirements of RCRA Section 3004(u). Included in the RFA are (1) a listing of all sites identified at ORNL that could be considered sources of releases or potential releases; (2) background information on each of these sites, including location, type, size, period of operation, current operational status, and information on observed or potential releases (as required in Section II.A.1 of the RCRA permit); (3) analytical results obtained from preliminary surveys conducted to verify the presence or absence of releases from some of the sites; and (4) ORNL's assessment of the need for further remedial attention.

  9. RCRA Facilities Assessment (RFA)---Oak Ridge National Laboratory

    SciTech Connect

    Not Available

    1987-03-01

    US Department of Energy (DOE) facilities are required to be in full compliance with all federal and state regulations. In response to this requirement, the Oak Ridge National Laboratory (ORNL) has established a Remedial Action Program (RAP) to provide comprehensive management of areas where past and current research, development, and waste management activities have resulted in residual contamination of facilities or the environment. This report presents the RCRA Facility Assessment (RFA) required to meet the requirements of RCRA Section 3004(u). Included in the RFA are (1) a listing of all sites identified at ORNL that could be considered sources of releases or potential releases; (2) background information on each of these sites, including location, type, size, period of operation, current operational status, and information on observed or potential releases (as required in Section II.A.1 of the RCRA permit); (3) analytical results obtained from preliminary surveys conducted to verify the presence or absence of releases from some of the sites; and (4) ORNL`s assessment of the need for further remedial attention.

  10. Superfund TIO videos. Set A. Regulatory overview - CERCLA's relationship to other programs: RCRA, Title III, UST, CWA, SDWA. Part 1. Audio-Visual

    SciTech Connect

    Not Available

    1990-01-01

    The videotape is divided into five sections. Section 1 provides definitions and historical information on both the Resource Conservation and Recovery Act (RCRA) and the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). The four types of RCRA regulatory programs - Subtitles C, D, I, and J - are described. Treatment, storage, and disposal (TSD) and recycling facilities are also discussed. Section 2 discusses the history behind the Emergency Planning and Community Right-to-Know Act (Title III). The four major provisions of Title III, which are emergency planning, emergency release notification, community right-to-know reporting, and the toxic chemical release inventory are covered. Section 3 outlines the UST program covering notification, record keeping, and the UST Trust Fund. Section 4 outlines the six major provisions of the Clean Water Act (CWA): water quality, pretreatment, prevention of oil and hazardous substance discharges, responses to oil and hazardous substance discharges, discharges of hazardous substances into the ocean, and dredge and fill. Section 5 explains the purpose, regulations, and standards of the Safe Drinking Water Act (SDWA). Specific issues such as underground injection, sole source aquifers, and lead contamination are discussed.

  11. Social impact evaluation of the US Resource Conservation and Recovery Act

    NASA Astrophysics Data System (ADS)

    Poppitti, James; Dietz, Thomas

    1983-11-01

    Debate over environmental policy often focuses on social impacts of those policies, but few empirical studies examine the impacts of environmental regulations once they are implemented. A quasi-experimental design based on survey data is used to assess the social impacts of the US Resource Conservation and Recovery Act (RCRA) on the West Virginia chemical industry. Changes in employment, manufacturing process, product line, and manufacturing costs are evaluated. RCRA seems to have produced changes in manufacturing processes, but we find no statistically significant impacts on.jobs, product line, or manufacturing costs.

  12. 7 CFR 868.10 - Information about the Service, Act, and regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Information about the Service, Act, and regulations... § 868.10 Information about the Service, Act, and regulations. Information about the Service, Act... INSPECTION, PACKERS AND STOCKYARD ADMINISTRATION (FEDERAL GRAIN INSPECTION SERVICE), DEPARTMENT...

  13. 77 FR 57199 - 2012 Real Estate Settlement Procedures Act (Regulation X) Mortgage Servicing Proposal

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ...The Bureau of Consumer Financial Protection (the Bureau) is proposing to amend Regulation X, which implements the Real Estate Settlement Procedures Act of 1974 (RESPA) and the official interpretation of the regulation. The proposed amendments implement the Dodd-Frank Wall Street Reform and Consumer Protection Act (Dodd-Frank Act) provisions regarding mortgage loan servicing. Specifically, this......

  14. RCRA, superfund and EPCRA hotline training module. Introduction to: Hazardous waste identification (40 cfr part 261) updated July 1996

    SciTech Connect

    1996-07-01

    The module introduces a specific hazardous waste identification process, which involves asking and analyzing a series of questions about any waste being evaluated. It analyzes in detail the Resource Conservation and Recovery Act (RCRA) definition of `hazardous waste.` It explains concepts that are essential to identifying a RCRA hazardous waste: hazardous waste listing, hazardous waste characteristics, the `mixture` and `derived-from` rules, the `contained-in` policy, and the hazardous waste identification rules (HWIR).

  15. CY2003 RCRA GROUNDWATER MONITORING WELL SUMMARY REPORT

    SciTech Connect

    MARTINEZ, C.R.

    2003-12-16

    This report describes the calendar year (CY) 2003 field activities associated with the installation of two new groundwater monitoring wells in the A-AX Waste Management Area (WMA) and four groundwater monitoring wells in WMA C in the 200 East Area of the Hanford Nuclear Reservation. All six wells were installed by Fluor Hanford Inc. (FH) for CH2M Hill Hanford Group, Inc. (CHG) in support of Draft Hanford Facility Agreement and Consent Order (Tri-Party Agreement) M-24-00 milestones and ''Resource Conservation and Recovery Act of 1976'' (RCRA) groundwater monitoring requirements. Drilling data for the six wells are summarized in Table 1.

  16. RCRA corrective action for underground storage tanks -- Subtitle C for Subtitle I

    SciTech Connect

    1995-08-01

    The purpose of this report is to provide guidance to DOE and DOE contractor personnel responsible for planning and implementation of corrective measures addressing cleanup of releases of hazardous materials or regulated substances from underground storage tanks regulated under RCRA Subtitle C or Subtitle I.

  17. RCRA SUBTITLE D (258): SEISMIC DESIGN GUIDANCE FOR MUNICIPAL SOLID WASTE LANDFILL FACILITIES

    EPA Science Inventory

    On October 9, 1993, the new RCRA Subtitle D regulations (40 CFR Part 258) went into effect. These regulations are applicable to landfills receiving municipal solid waste (MSW) and establish minimum Federal criteria for the siting, design, operation, and closure of MSW landfills....

  18. RCRA Part B Permit Application for the Idaho National Engineering Laboratory - Volume 5 Radioactive Waste Management Complex

    SciTech Connect

    Pamela R. Cunningham

    1992-07-01

    This section of the Radioactive Waste Management Complex (RWMC) Part B permit application describes the waste characteristics Of the transuranic (TRU) mixed wastes at the RWMC waste management units to be permitted: the Intermediate-Level Transuranic Storage Facility (ILTSF) and the Waste Storage Facility (WSF). The ILTSF is used to store radioactive remote-handled (RH) wastes. The WSF will be used to store radioactive contact-handled (CH) wastes. The Transuranic Storage Area (TSA) was established at the RWMC to provide interim storage of TRU waste. Department of Energy (DOE) Order 5820.2A defines TRU waste as waste contaminated with alpha-emitting transuranium radionuclides with half-lives greater than 20 years in concentrations greater than 100 nanocuries per gram (nCi/g) o f waste material. The TSA serves generators both on and off the Idaho National Engineering Laboratory (INEL). The ILTSF is located at the TSA, and the WSF will be located there also. Most of the wastes managed at the TSA are mixed wastes, which are radioactive wastes regulated under the Atomic Energy Act (AEA) that also contain hazardous materials regulated under the Resource Conservation and Recovery Act (RCRA) and the Idaho Hazardous Waste Management Regulations. These wastes include TRU mixed wastes and some low-level mixed wastes. Accordingly, the TSA is subject to the permitting requirements of RCRA and the Idaho Administrative Procedures Act (IDAPA). Prior to 1982, DOE orders defined TRU wastes as having transuranium radionuclides in concentrations greater than 10 nCi/g, The low-level mixed wastes managed at the TSA are those wastes with 10 to 100 nCi/g of TRU radionuclides that prior to 1982 were considered TRU waste.

  19. 21 CFR 16.24 - Regulatory hearing required by the act or a regulation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... regulation. 16.24 Section 16.24 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN....24 Regulatory hearing required by the act or a regulation. (a) A regulatory hearing required by the act or a regulation under § 16.1(b) will be initiated in the same manner as other regulatory...

  20. 21 CFR 16.24 - Regulatory hearing required by the act or a regulation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... regulation. 16.24 Section 16.24 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN....24 Regulatory hearing required by the act or a regulation. (a) A regulatory hearing required by the act or a regulation under § 16.1(b) will be initiated in the same manner as other regulatory...

  1. 75 FR 58387 - Federal Acquisition Regulation; Information Collection; American Recovery and Reinvestment Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-24

    ... Regulation; Information Collection; American Recovery and Reinvestment Act-Reporting Requirements--One-Time... an extension of a currently approved information collection requirement concerning the American Recovery and Reinvestment Act-Reporting Requirements--One Time- Reporting, Compensation...

  2. 75 FR 58388 - Federal Acquisition Regulation; Information Collection; American Recovery and Reinvestment Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-24

    ... Regulation; Information Collection; American Recovery and Reinvestment Act-Reporting Requirements--Quarterly... an extension of a currently approved information collection requirement concerning the American Recovery and Reinvestment Act--Quarterly Reporting for Prime Contractors. Public comments are...

  3. US Department of Energy`s Federal Facility Compliance Act Chief Financial Officer`s Report to Congress for fiscal year 1993

    SciTech Connect

    Not Available

    1993-12-01

    The Federal Facility Compliance Act of 1992 (FFCAct) (Public Law 102-386) was enacted into law on October 6, 1992. In addition to amending the Resource Conservation and Recovery Act (RCRA), the FFCAct requires the US Department of Energy (DOE) to prepare an annual report from the Chief Financial Officer to the Congress on compliance activities undertaken by the DOE with regard to mixed waste streams and provide an accounting of the fines and penalties imposed upon the DOE for violations involving mixed waste. This document has been prepared to report the necessary information. Mixed waste is defined by the FFCAct to include those wastes containing both hazardous waste as defined in the RCRA and source, special nuclear, or byproduct material subject to the Atomic Energy Act of 1954, as amended (42 U.S.C. Section 2001 et seq.). Section 2 of this report briefly summarizes DOE Headquarters` activities conducted during Fiscal Year 1993 (FY 1993) to comply with the requirements of the FFCAct. Section 3 of this report provides an overview of the site-specific RCRA compliance activities, relating to mixed waste streams, conducted in FY 1993 for those sites that currently generated or store mixed waste that are subject to regulation under RCRA. Section 4 provides information on notifications of alleged RCRA violations involving mixed waste imposed upon the DOE during FY 1993 and an accounting of any fines and penalties associated with these violations. Appendix A provides site-specific summaries of RCRA compliance activities, relating to mixed waste streams, conducted in FY 1993 for those sites that currently generate or store mixed waste that are subject to regulation under RCRA.

  4. SEMINAR PUBLICATION: DESIGN AND CONSTRUCTION OF RCRA/CERCLA FINAL COVERS

    EPA Science Inventory

    Cover systems are an essential part of all land disposal facilities. Covers control moisture infiltration from the surface into closed facilities and limit the formation of leachate and its migration to ground water. The Resource Conservation and Recovery Act (RCRA) Subparts G, K...

  5. RCRA and operational monitoring 1994 fiscal year work plan, WBS 1.5.3

    SciTech Connect

    Not Available

    1993-12-01

    RCRA & Operational Monitoring (ROM) Program Office manages the direct funded Resource Conservation Recovery Act (RCRA) and Operational Monitoring under Work Breakdown Structure (WBS) 1.5.3. The ROM Program Office is a Branch of liquid Waste Disposal, a part of Restoration and Remediation of Westinghouse Hanford Company (WHC). The Fiscal Year Work Plan (FYWP) takes it direction from the Multi-Year Program Plan (MYPP). The FYWP provides the near term, enhanced details for the Program Office to use as baseline Cost, Scope and Schedule. Changs Control administered during the fiscal year is against the baseline provided by the FYWP.

  6. Metals reclaimer urges agency to put RCRA on track

    SciTech Connect

    Borner, A.J. ); Perry, B.

    1991-11-01

    Twenty-five years ago, the nation yawned, tentatively scratched, then hiccuped its first official awareness of an environmental tumor with the passage of the 1965 Solid Waste Disposal Act. This was the first federal law requiring environmentally sound disposal of household, municipal, commercial and industrial refuse. Earth Day '70 rallies goaded a still sleepy congress into amending the law with the 1970 Resource Recovery Act-a legislative misnomer that would be compounded in 1976 by passage of RCRA. In 1980, RCRA again was amended, and the ruse of a nation struggling toward conservation and recovery continued. EPA's and the Department of Justice's (DOJ) indecision over whether Marine Shale Processors Inc. (St. Rose, La.) is an exempt recycler or a TSDF requiring the permits and scrutiny that status implies is evidence of this ruse. This article explores the risks, frustrations and opportunities encountered by a company that boldly has opted to enter the hazardous waste recycling market despite regulatory uncertainties, competitive disadvantages and difficulties breaking potential clients' disposal habits that include deep-well injection and landfilling valuable resources.

  7. RCRA Facility Investigation/Remedial Investigation Report with Baseline Risk Assessment for the Fire Department Hose Training Facility (904-113G)

    SciTech Connect

    Palmer, E.

    1997-04-01

    This report documents the Resource Conservation and Recovery Act (RCRA) Facility Investigation/Remedial Investigation/Baseline Risk Assessment (RFI/RI/BRA) for the Fire Department Hose Training Facility (FDTF) (904-113G).

  8. 78 FR 20291 - Fisheries of the United States; Billfish Conservation Act of 2012 Implementing Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-04

    .... SUPPLEMENTARY INFORMATION: Background The Billfish Conservation Act of 2012 (BCA), Public Law 112-183, 16 U.S.C... States; Billfish Conservation Act of 2012 Implementing Regulations AGENCY: National Marine Fisheries... the implementation of the Billfish Conservation Act of 2012. DATES: Written comments regarding...

  9. 76 FR 24027 - Federal Acquisition Regulation; Information Collection; Buy American Act Certificate

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-29

    ... Regulation; Information Collection; Buy American Act Certificate AGENCY: Department of Defense (DOD), General... previously approved information collection requirement concerning the Buy American Act certificate. Public...-mail cecelia.davis@gsa.gov . SUPPLEMENTARY INFORMATION: A. Purpose The Buy American Act requires...

  10. 75 FR 14547 - Tribal Consultation on Draft Buy Indian Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-26

    ... Bureau of Indian Affairs 48 CFR Chapter 14 RIN 1076-AE95 Tribal Consultation on Draft Buy Indian Act... comments concerning draft regulations to implement the Buy Indian Act. See the SUPPLEMENTARY INFORMATION... implementation of the Buy Indian Act, 25 U.S.C. 47, which provides authority to set aside procurement...

  11. 78 FR 70515 - Petition To Promulgate Standards for Bears Under the Animal Welfare Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-26

    ... Standards for Bears Under the Animal Welfare Act Regulations AGENCY: Animal and Plant Health Inspection... Health Inspection Service has received a petition requesting that we amend the Animal Welfare Act..., Riverdale, MD 20737-1234; (301) 851-3751. SUPPLEMENTARY INFORMATION: Background The Animal Welfare Act...

  12. 76 FR 68690 - Rules and Regulations Under the Textile Fiber Products Identification Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ... Wool Products Labeling Act, and the Fur Products Labeling Act: Final Rule, 63 FR 7508 (Feb. 13, 1998). \\2\\ Federal Trade Commission: Miscellaneous Rules: Final Rule, 63 FR 71582 (Dec. 29, 1998). \\3... and Regulations Under the Wool Products Labeling Act of 1939, Final Rule, 65 FR 75154 (Dec. 1,...

  13. 78 FR 29263 - Rules andRegulations Under the Textile Fiber Products Identification Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-20

    ... Under the Textile Fiber Products Identification Act, 76 FR 68690 (Nov. 7, 2011). This Notice of Proposed...--Rules and Regulations Under the Textile Fiber Products Identification Act, 24 FR 4480, 4485 (June 2... Rulemaking, 50 FR 15100 at 15101 (Apr. 15, 1985). This Notice compared the Customs regulations in 19 CFR...

  14. 78 FR 41835 - Inflation Adjustments to the Price-Anderson Act Financial Protection Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-12

    ... made the initial changes to the Price-Anderson Act amounts on October 27, 2005 (70 FR 61885), and the... Federal Regulations is sold by the Superintendent of Documents. #0;Prices of new books are listed in the... 3150-AJ25 Inflation Adjustments to the Price-Anderson Act Financial Protection Regulations...

  15. 5 CFR 293.202 - Records subject to Office or agency Privacy Act regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Privacy Act regulations. 293.202 Section 293.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT... Records subject to Office or agency Privacy Act regulations. When the Office of Personnel Management publishes in the Federal Register a notice of system of records for personnel records which are...

  16. Approach for addressing dioxin in soils at CERCLA and RCRA sites. Directive

    SciTech Connect

    1997-04-13

    The purpose of this Directive is to recommend preliminary remediation goals (PRGs) or starting points for setting cleanup levels for dioxin in soil at Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) and Resource Conservation and Recovery Act (RCRA) corrective action sites. These recommended levels are to be used pending the release of the U.S. Environmental Protection Agency (EPA) comprehensive dioxin reassessment report and cross-program assessment of the impacts of the report.

  17. 77 FR 57043 - Regulations Under the Fur Products Labeling Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ... Labeling Act (``TFLA''), and, on its own initiative, deleting unnecessary requirements. \\1\\ 76 FR 13550..., most recently in 1967.\\17\\ \\16\\ 15 U.S.C. 69e(b). \\17\\ 32 FR 6023 (Apr. 15, 1967). C. TFLA In 2010....ftc.gov/opa/2011/07/regreview.shtm . \\24\\ 76 FR 13550. \\25\\ The comments, along with a transcript...

  18. 77 FR 50390 - Equal Credit Opportunity Act (Regulation B)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-21

    ..., such as account numbers or social security numbers, should not be included. Comments will not be edited... from the Bureau's rulemaking authority by section 1029 of the Dodd-Frank Act). 76 FR 79442 (Dec. 21...-reference to the definition of ``dwelling'' that, as discussed below, is proposed to be moved to Sec....

  19. 75 FR 22320 - Regulations Implementing the Freedom of Information Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-28

    ... From the Federal Register Online via the Government Publishing Office OCCUPATIONAL SAFETY AND... Government Act), as well as changes in OSHRC's own policies and procedures. DATES: Submit comments on or before May 28, 2010. ADDRESSES: OSHRC encourages electronic submission of comments. You may...

  20. 77 FR 66539 - Freedom of Information Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-06

    ... electronic records and automated searches along with paper records and manual searches. In addition, FMCS's... twenty cents per page, while document search and review charges will increase to $4.00 per each quarter... revisions read as follows: Sec. 1401.36 Freedom of Information Act fee schedules. (a) * * * (2) Search...

  1. 78 FR 50351 - Freedom of Information Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ... without charge. These Direct Costs shall include the cost of operating a central processing unit for that... processing Requests for Information under the Freedom of Information Act (FOIA). The revisions reorganize the... reached before the NCPC charges members of the public a processing fee for information. DATES:...

  2. 78 FR 32595 - Revision of Freedom of Information Act Regulation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ..., entitled ``Freedom of Information Act'' (74 FR 4683, January 26, 2009) and ``Transparency and Openness'' (74 FR 4685, January 26, 2009), which encourage federal agencies to apply a presumption of disclosure... published by the Department of Justice (DOJ) on March 21, 2011 (76 FR 15236). DOJ intended for these...

  3. The Equal Access Act: Policy and Regulations for Implementation.

    ERIC Educational Resources Information Center

    Jones, H. Lawrence; Martin, James

    The Equal Access Act of 1984 was drafted to implement access for religious clubs to public secondary schools, but with constitutionally protected safeguards to preclude entanglement of church and state. A number of challenges were made on the constitutional grounds of excessive entanglement of church and state, as well as what the definition of…

  4. 76 FR 15841 - General Rules and Regulations, Securities Act of 1933

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-22

    ... COMMISSION 17 CFR Part 230 General Rules and Regulations, Securities Act of 1933 CFR Correction In Title 17 of the Code of Federal Regulations, Parts 200 to 239, revised as of April 1, 2010, on page 686, in.... 230.501 Definitions and terms used in Regulation D. * * * * * (e) * * * NOTE: The issuer must...

  5. The Final Regulations to the Carl D. Perkins Vocational and Applied Technology Education Act of 1990.

    ERIC Educational Resources Information Center

    American Vocational Association, Alexandria, VA.

    This publication presents the final regulations to the Carl D. Perkins Vocational and Applied Technology Education Act of 1990. The first section is an analysis of the regulations. This analysis compares the proposed regulations to the final version and explains the differences between the two and the potential impact on program administration.…

  6. Auxin acts independently of DELLA proteins in regulating gibberellin levels.

    PubMed

    Reid, James B; Davidson, Sandra E; Ross, John J

    2011-03-01

    Shoot elongation is a vital process for plant development and productivity, in both ecological and economic contexts. Auxin and bioactive gibberellins (GAs), such as GA1, play critical roles in the control of elongation, along with environmental and endogenous factors, including other hormones such as the brassinosteroids. The effect of auxins, such as indole-3-acetic acid (IAA), is at least in part mediated by its effect on GA metabolism, since auxin up-regulates biosynthesis genes such as GA 3-oxidase and GA 20-oxidase and down regulates GA catabolism genes such as GA 2-oxidases, leading to elevated levels of bioactive GA 1. In our recent paper, we have provided evidence that this action of IAA is largely independent of DELLA proteins, the negative regulators of GA action, since the auxin effects are still present in the DELLA-deficient la cry-s genotype of pea. This was a crucial issue to resolve, since like auxin, the DELLAs also promote GA 1 synthesis and inhibit its deactivation. DELLAs are deactivated by GA, and thereby mediate a feedback system by which bioactive GA regulates its own level. However, our recent results, in themselves, do not show the generality of the auxin-GA relationship across species and phylogenetic groups or across different tissue types and responses. Further, they do not touch on the ecological benefits of the auxin-GA interaction. These issues are discussed below as well as the need for the development of suitable experimental systems to allow this process to be examined. PMID:21358281

  7. RCRA Part A permit characterization plan for the U-2bu subsidence crater. Revision 1

    SciTech Connect

    1998-04-01

    This plan presents the characterization strategy for Corrective Action Unit (CAU) 109, U-2bu Subsidence Crater (referred to as U-2bu) in Area 2 at the Nevada Test Site (NTS). The objective of the planned activities is to obtain sufficient characterization data for the crater soils and observed wastes under the conditions of the current Resource Conservation and Recovery Act (RCRA) Part A permit. The scope of the characterization plan includes collecting surface and subsurface soil samples with hand augers and for the purpose of site characterization. The sampling strategy is to characterize the study area soils and look for RCRA constituents. Observable waste soils and surrounding crater soils will be analyzed and evaluated according to RCRA closure criteria. Because of the status of the crater a RCRA Part A permit site, acquired radionuclide analyses will only be evaluated in regards to the health and safety of site workers and the disposition of wastes generated during site characterization. The U-2bu Subsidence Crater was created in 1971 by a Lawrence Livermore National Laboratory underground nuclear test, event name Miniata, and was used as a land-disposal unit for radioactive and hazardous waste from 1973 to 1988.

  8. Brightening up: the effect of the Physician Payment Sunshine Act on existing regulation of pharmaceutical marketing.

    PubMed

    Gorlach, Igor; Pham-Kanter, Genevieve

    2013-01-01

    With the passage of the Physician Payment Sunshine Act as part of the federal health care reform law, pharmaceutical manufacturers are now required to disclose a wide range of payments made by manufacturers to physicians. We review current state regulation of pharmaceutical marketing and consider how the federal sunshine provision will affect existing marketing regulation. We analyze the legal and practical implications of the Physician Payment Sunshine Act.

  9. Brightening up: the effect of the Physician Payment Sunshine Act on existing regulation of pharmaceutical marketing.

    PubMed

    Gorlach, Igor; Pham-Kanter, Genevieve

    2013-01-01

    With the passage of the Physician Payment Sunshine Act as part of the federal health care reform law, pharmaceutical manufacturers are now required to disclose a wide range of payments made by manufacturers to physicians. We review current state regulation of pharmaceutical marketing and consider how the federal sunshine provision will affect existing marketing regulation. We analyze the legal and practical implications of the Physician Payment Sunshine Act. PMID:23581674

  10. The Fair Labor Standards Act and the Child Care Industry--What Regulations Apply.

    ERIC Educational Resources Information Center

    Lee, Elisa

    1996-01-01

    Discusses how the federal Fair Labor Standard Act (FLSA) affects the wages and work hours of child care employees and how FLSA interacts with analogous state laws. Examines how child care centers can determine whether FLSA regulations apply to them, existing exemptions to the current act, minimum wage and overtime, whether training time is working…

  11. 20 CFR 626.2 - Format of the Job Training Partnership Act regulations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., including complaint processing and compliance reviews, will be governed by the provisions of 29 CFR part 34... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Format of the Job Training Partnership Act... LABOR INTRODUCTION TO THE REGULATIONS UNDER THE JOB TRAINING PARTNERSHIP ACT § 626.2 Format of the...

  12. 20 CFR 626.2 - Format of the Job Training Partnership Act regulations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., including complaint processing and compliance reviews, will be governed by the provisions of 29 CFR part 34... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Format of the Job Training Partnership Act... LABOR INTRODUCTION TO THE REGULATIONS UNDER THE JOB TRAINING PARTNERSHIP ACT § 626.2 Format of the...

  13. 20 CFR 626.4 - Table of contents for the Job Training Partnership Act regulations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the Job Training Partnership Act, 20 CFR parts 626-638 and 1005, 1 is as follows: 1 Part 1005 was... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Table of contents for the Job Training..., DEPARTMENT OF LABOR INTRODUCTION TO THE REGULATIONS UNDER THE JOB TRAINING PARTNERSHIP ACT § 626.4 Table...

  14. 20 CFR 626.4 - Table of contents for the Job Training Partnership Act regulations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... the Job Training Partnership Act, 20 CFR parts 626-638 and 1005, 1 is as follows: 1 Part 1005 was... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Table of contents for the Job Training..., DEPARTMENT OF LABOR INTRODUCTION TO THE REGULATIONS UNDER THE JOB TRAINING PARTNERSHIP ACT § 626.4 Table...

  15. 78 FR 54648 - Federal Acquisition Regulation; Information Collection; American Recovery and Reinvestment Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-05

    ... Regulation; Information Collection; American Recovery and Reinvestment Act--Reporting Requirements--One-Time... identified by Information Collection 9000- 0168, American Recovery and Reinvestment Act--Reporting..., company name (if any), and ``Information Collection 9000-0168, American Recovery and Reinvestment...

  16. 78 FR 54650 - Federal Acquisition Regulation; Information Collection American Recovery and Reinvestment Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-05

    ... Regulation; Information Collection American Recovery and Reinvestment Act-Reporting Requirements--One-Time... comments identified by Information Collection 9000- 0167, American Recovery and Reinvestment Act-Reporting.... Instructions: Please submit comments only and cite Information Collection 9000-0167, American Recovery...

  17. 76 FR 40367 - Federal Acquisition Regulation; Information Collection; Buy American Act-Construction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-08

    ... (Grimberg Decision). Public comments are particularly invited on: Whether this collection of information is..., American Act--Construction (Grimberg Decision), by any of the following methods: ] Regulations.gov : http... Collection 9000-0141,'' American Act--Construction (Grimberg Decision), under the heading ``Enter Keyword...

  18. RCRA closure of mixed waste impoundments

    SciTech Connect

    Blaha, F.J.; Greengard, T.C.; Arndt, M.B.

    1989-11-01

    A case study of a RCRA closure action at the Rocky Flats Plant is presented. Closure of the solar evaporation ponds involves removal and immobilization of a mixed hazardous/radioactive sludge, treatment of impounded water, groundwater monitoring, plume delineation, and collection and treatment of contaminated groundwater. The site closure is described within the context of regulatory negotiations, project schedules, risk assessment, clean versus dirty closure, cleanup levels, and approval of closure plans and reports. Lessons learned at Rocky Flats are summarized.

  19. RCRA/UST, superfund and EPCRA hotline training module. Introduction to: Hazardous waste identification (40 CFR part 261) updated as of July 1995

    SciTech Connect

    1995-11-01

    This module introduces a specific hazardous waste identification process, which involves asking and analyzing a series of questions about any waste being evaluated. Analyzes in detail the Resource Conservation and Recovery Act (RCRA) definition of hazardous waste. It explains the following concepts that are essential to identifying a RCRA hazardous waste: hazardous waste listing, hazardous waste characteristics, the mixture and derived-from rules, the contained-in policy, and the Hazardous Waste Identification Rule (HWIR).

  20. 77 FR 38717 - Updating Regulations Issued Under the Fair Labor Standards Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Wage and Hour Division 29 CFR Parts 531 and 553 Updating Regulations Issued Under the Fair Labor Standards Act CFR Correction In Title 29 of the Code of Federal Regulations, Parts 500 to 899, revised as of July...

  1. 7 CFR 27.4 - Obligations and rights under Act: not affected by regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Obligations and rights under Act: not affected by regulations. 27.4 Section 27.4 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS...

  2. 7 CFR 27.95 - Spot markets to conform to Act and regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Spot markets to conform to Act and regulations. 27.95 Section 27.95 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND...

  3. 40 CFR 261.8 - PCB wastes regulated under Toxic Substance Control Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false PCB wastes regulated under Toxic... (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE General § 261.8 PCB wastes regulated under Toxic Substance Control Act. The disposal of PCB-containing dielectric fluid and...

  4. 40 CFR 261.8 - PCB wastes regulated under Toxic Substance Control Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false PCB wastes regulated under Toxic... (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE General § 261.8 PCB wastes regulated under Toxic Substance Control Act. The disposal of PCB-containing dielectric fluid and...

  5. 40 CFR 261.8 - PCB wastes regulated under Toxic Substance Control Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 26 2014-07-01 2014-07-01 false PCB wastes regulated under Toxic... (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE General § 261.8 PCB wastes regulated under Toxic Substance Control Act. The disposal of PCB-containing dielectric fluid and...

  6. 40 CFR 261.8 - PCB wastes regulated under Toxic Substance Control Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false PCB wastes regulated under Toxic... (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE General § 261.8 PCB wastes regulated under Toxic Substance Control Act. The disposal of PCB-containing dielectric fluid and...

  7. 40 CFR 261.8 - PCB wastes regulated under Toxic Substance Control Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false PCB wastes regulated under Toxic... (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE General § 261.8 PCB wastes regulated under Toxic Substance Control Act. The disposal of PCB-containing dielectric fluid and...

  8. 76 FR 78130 - Mortgage Acts and Practices-Advertising (Regulation N); Mortgage Assistance Relief Services...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ... the Bureau, the Bureau is publishing for public comment an interim final rule establishing a new Regulation N (Mortgage Acts and Practices-- Advertising Rule) and a new Regulation O (Mortgage Assistance Relief Services Rule). This interim final rule does not impose any new substantive obligations on...

  9. 75 FR 59609 - Rescission of Regulations Under the Comprehensive Smokeless Tobacco Health Education Act of 1986

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-28

    ... its smokeless tobacco regulations, 16 CFR Part 307, on November 4, 1986.\\1\\ 51 FR 40015. \\1\\ The... on utilitarian items. 56 FR 11654 (Mar. 20, 1991). II. Basis for Removal of Regulations On June 22... the enactment of the Family Smoking Prevention Act. 75 FR 3665 (Jan. 22, ] 2010). The...

  10. 78 FR 8963 - Update of Existing Privacy Act-NASA Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-07

    ... document contains corrections to the final regulations (NASA-2012-0005), which were published in the Federal Register of Thursday, October 4, 2012 (77 FR 60620). The regulations relate to requests to access... SPACE ADMINISTRATION 14 CFR Part 1212 RIN 2700-AD86 Update of Existing Privacy Act--NASA...

  11. Quarterly report of RCRA groundwater monitoring data for period October 1, 1992--December 31, 1992

    SciTech Connect

    Not Available

    1993-04-01

    Hanford Site interim-status groundwater monitoring projects are conducted as either background, indicator parameter evaluation, or groundwater quality assessment monitoring programs as defined in the Resource Conservation and Recovery Act of 1976 (RCRA); and Interim Status Standards for Owners and Operators of Hazardous Waste Treatment, Storage, and Disposal Facilities, as amended (40 CFR 265). Compliance with the 40 CFR 265 regulations is required by the Washington Administrative Code (WAC) 173-303. Long-term laboratory contracts were approved on October 22, 1991. DataChem Laboratories of Salt Lake City, Utah, performs the hazardous chemicals analyses for the Hanford Site. Analyses for coliform bacteria are performed by Columbia/Biomedical Laboratories and for dioxin by TMS Analytical Services, Inc. International Technology Analytical Services Richland, Washington performs the radiochemical analyses. This quarterly report contains data that were received prior to March 8, 1993. This report may contain not only data from the October through December quarter but also data from earlier sampling events that were not previously reported.

  12. Phase 1 RCRA Facility Investigation and Corrective Measures Study Work Plan for Single Shell Tank Waste Management Areas

    SciTech Connect

    ROGERS, P.M.

    2000-06-01

    This document is the master work plan for the Resource Conservation and Recovery Act of 1976 (RCRA) for single-shell tank (SST) farms at the Hanford Site. Evidence indicates that releases at four of the seven SST waste management areas have impacted.

  13. 76 FR 76158 - Agency Information Collection Activities; Proposed Collection; Comment Request; RCRA Expanded...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-06

    ... AGENCY Agency Information Collection Activities; Proposed Collection; Comment Request; RCRA Expanded... approved Information Collection Request (ICR) concerning RCRA public participation. This ICR is scheduled... Docket ID No. EPA-HQ- RCRA-2011-0890, by one of the following methods:...

  14. RCRA, superfund and EPCRA hotline training module. Introduction to: RCRA state programs updated June 1996

    SciTech Connect

    1996-06-01

    The module outlines the requirements and procedures for a state to become authorized to manage and oversee its own RCRA program. It also describes how the state authorization system can affect the applicability of certain rules. When one has completed the module they will be familiar with the state authorization process for hazardous waste management programs.

  15. 76 FR 43585 - Bank Secrecy Act Regulations; Definitions and Other Regulations Relating to Money Services...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-21

    ... 31 of the Code of Federal Regulations for the BSA regulations. See 75 FR 65806 (October 26, 2010... Proposed Rulemaking, Definitions and Other Regulations Relating to Money Services Businesses, 74 FR 22129... financing of terrorist activities; \\7\\ (2) file Currency Transaction Reports (``CTRs'') \\8\\ and...

  16. RCRA Part A and Part B Permit Application for Waste Management Activities at the Nevada Test Site: Proposed Mixed Waste Disposal Unit (MWSU)

    SciTech Connect

    NSTec Environmental Management

    2010-07-19

    The proposed Mixed Waste Storage Unit (MWSU) will be located within the Area 5 Radioactive Waste Management Complex (RWMC). Existing facilities at the RWMC will be used to store low-level mixed waste (LLMW). Storage is required to accommodate offsite-generated LLMW shipped to the Nevada Test Site (NTS) for disposal in the new Mixed Waste Disposal Unit (MWDU) currently in the design/build stage. LLMW generated at the NTS (onsite) is currently stored on the Transuranic (TRU) Pad (TP) in Area 5 under a Mutual Consent Agreement (MCA) with the Nevada Division of Environmental Protection, Bureau of Federal Facilities (NDEP/BFF). When the proposed MWSU is permitted, the U.S. Department of Energy (DOE) will ask that NDEP revoke the MCA and onsite-generated LLMW will fall under the MWSU permit terms and conditions. The unit will also store polychlorinated biphenyl (PCB) waste and friable and non-friable asbestos waste that meets the acceptance criteria in the Waste Analysis Plan (Exhibit 2) for disposal in the MWDU. In addition to Resource Conservation and Recovery Act (RCRA) requirements, the proposed MWSU will also be subject to Department of Energy (DOE) orders and other applicable state and federal regulations. Table 1 provides the metric conversion factors used in this application. Table 2 provides a list of existing permits. Table 3 lists operational RCRA units at the NTS and their respective regulatory status.

  17. RCRA enforcement policy compendium. Volumes 1, 2 and 3

    SciTech Connect

    Not Available

    1992-09-01

    The compendium is a compilation of documents originated by the Office of Waste Programs Enforcement, RCRA Enforcement Division. Documents contained in the compendium were issued after 1980 and are related to RCRA Enforcement. The compendium also consists of documents originated by the Office of Emergency and Remedial Response, Office of Enforcement, and Office of Solid Waste.

  18. Groundwater monitoring plan for the Hanford Site 216-B-3 pond RCRA facility

    SciTech Connect

    Barnett, D.B.; Chou, C.J.

    1998-06-01

    The 216-B-3 pond system was a series of ponds for disposal of liquid effluent from past Hanford production facilities. In operation since 1945, the B Pond system has been a RCRA facility since 1986, with Resource Conservation and Recovery Act (RCRA) interim-status groundwater monitoring in place since 1988. In 1994, discharges were diverted from the main pond, where the greatest potential for contamination was thought to reside, to the 3C expansion pond. In 1997, all discharges to the pond system were discontinued. In 1990, the B Pond system was elevated from detection groundwater monitoring to an assessment-level status because total organic halogens and total organic carbon were found to exceed critical means in two wells. Subsequent groundwater quality assessment failed to find any specific hazardous waste contaminant that could have accounted for the exceedances, which were largely isolated in occurrence. Thus, it was recommended that the facility be returned to detection-level monitoring.

  19. RCRA (Resource Conservation and Recovery Act) waste oversight: Lead

    SciTech Connect

    Alexander, W.A.

    1987-01-01

    Historically, in the nuclear industry, water, concrete, steel, and lead have been common materials used for radiation shielding purposes. Lead, a high-density material, is a very effective shield for gamma radiation and has been utilized extensively at the Oak Ridge National Laboratory (ORNL) in association with radioisotope production and nuclear research. During these activities, lead became an inherent part of the radioactive waste and was disposed of in massive quantities by land burial.

  20. 78 FR 39901 - Amendments to the 2013 Mortgage Rules Under the Equal Credit Opportunity Act (Regulation B), Real...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ... purposes under the mortgage regulations, application of the loan originator compensation rules to bank... Bureau issued Escrow Requirements Under the Truth in Lending Act (Regulation Z), 78 FR 4726 (Jan. 30... Settlement Procedures Act (Regulation X), 78 FR 6856 (Jan. 31, 2013) (2013 HOEPA Final Rule), and Ability...

  1. Evaluation of an Alternative Statistical Method for Analysis of RCRA Groundwater Monitoring Data at the Hanford Site

    SciTech Connect

    Chou, Charissa J.

    2004-06-24

    Statistical methods are required in groundwater monitoring programs to determine if a RCRA-regulated unit affects groundwater quality beneath a site. This report presents the results of the statistical analysis of groundwater monitoring data acquired at B Pond and the 300 Area process trenches during a 2-year trial test period.

  2. 75 FR 24862 - Removing Regulations Implementing the Fish and Wildlife Conservation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-06

    ...'' (59 FR 22951), E.O. 13175, and 512 DM 2. We have determined that there are no potential effects. This... Fish and Wildlife Service 50 CFR Part 83 RIN 1018-AX00 Removing Regulations Implementing the Fish and Wildlife Conservation Act AGENCY: Fish and Wildlife Service, Interior. ACTION: Proposed rule. SUMMARY:...

  3. 75 FR 36589 - Financial Crimes Enforcement Network; Amendment to the Bank Secrecy Act Regulations-Definitions...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-28

    ... revise the Bank Secrecy Act (``BSA'') regulations applicable to Money Services Businesses with regard to...-bank financial institutions that offer specific services (often in combination) and are without a... Services Business NPRM On May 12, 2009, FinCEN published an NPRM entitled ``Amendment to the Bank...

  4. Impact of Clean Air Act Regulations on Nitrogen Fate and Transport in Neuse River Basin

    EPA Science Inventory

    This study investigated impacts of Clean Air Act Amendment (CAAA) NOx emissions regulations on the fate and transport of nitrogen for two watersheds in the Neuse River Basin, North Carolina, USA from 1990 to 2020. The Soil and Water Assessment Tool (SWAT) and the Community Multi-...

  5. The National Labor Relations Act and the Regulation of Public Employee Collective Bargaining

    ERIC Educational Resources Information Center

    McCann, Walter; Smiley, Stafford

    1976-01-01

    The arguments for and against federal assumption of the responsibility for regulating the relationship between public employers and public employees are analyzed. It is suggested that the National Labor Relations Act should be extended to include them, thereby imposing upon them a duty to bargain collectively. Available from: the Harvard…

  6. 75 FR 40754 - Government in the Sunshine Act Regulations of the National Science Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-14

    ... From the Federal Register Online via the Government Publishing Office NATIONAL SCIENCE FOUNDATION 45 CFR Part 614 RIN 3145-AA53 Government in the Sunshine Act Regulations of the National Science Board AGENCY: National Science Board (NSB), National Science Foundation (NSF). ACTION: Direct final...

  7. 77 FR 234 - Rules and Regulations Under the Textile Fiber Products Identification Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-04

    ...; ] FEDERAL TRADE COMMISSION 16 CFR Part 303 Rules and Regulations Under the Textile Fiber Products Identification Act AGENCY: Federal Trade Commission (``FTC'' or ``Commission''). ACTION: Extension of the... to the following address: Federal Trade Commission, Office of the Secretary, Room H-113 (Annex...

  8. 77 FR 4498 - Rules and Regulations Under the Wool Products Labeling Act of 1939

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-30

    ...: Miscellaneous Rules: Final Rule, 63 FR 71582 (Dec. 29, 1998). \\7\\ Federal Trade Commission: Rules and... and Request for Public Comment on the Federal Trade Commission's Regulatory Review Program, 76 FR...; ] FEDERAL TRADE COMMISSION 16 CFR Part 300 Rules and Regulations Under the Wool Products Labeling Act...

  9. 75 FR 19241 - Financial Crimes Enforcement Network; Amendment to the Bank Secrecy Act Regulations; Defining...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-14

    ... for Mutual Funds, 67 FR 21117 (April 29, 2002); Customer Identification Programs for Mutual Funds, 68 FR 25131 (May 9, 2003); Amendment to the Bank Secrecy Act Regulations--Requirement That Mutual Funds Report Suspicious Activity, 71 FR 26213 (May 4, 2006); Anti-Money Laundering Programs; Special...

  10. 75 FR 58390 - Federal Acquisition Regulation; Information Collection; American Recovery and Reinvestment Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-24

    ... Regulation; Information Collection; American Recovery and Reinvestment Act-Reporting Requirements--One-Time... extension of a currently approved information collection requirement concerning the American Recovery and... particularly invited on: Whether this collection of information is necessary for the proper performance...

  11. 78 FR 27308 - Loan Originator Compensation Requirements Under the Truth In Lending Act (Regulation Z...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-10

    ... adopting Sec. 1026.36(i). \\1\\ 78 FR 11279 (Feb. 15, 2013). A. Title XIV Rulemaking Effective Dates In... become effective sooner than January 2014.\\5\\ \\5\\ 77 FR 55272 (Sept. 7, 2012). The Bureau received very... Requirements Under the Truth In Lending Act (Regulation Z); Prohibition on Financing Credit Insurance...

  12. 76 FR 52295 - Amendment of Privacy Act Regulations, Request for Comments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR 43 CFR Part 2 RIN 1090-AA94 Amendment of Privacy Act Regulations, Request for Comments AGENCY: Office... on October 3, 2011. ADDRESSES: Send written comments, identified by RIN 1090-AA94, by one of...

  13. 76 FR 20569 - Horse Protection Act; Petition for Amendments to Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ... Animal and Plant Health Inspection Service 9 CFR Part 11 Horse Protection Act; Petition for Amendments to... changes to our horse protection regulations and our current enforcement practices and related policies... are noting, however, that certain requests in the petition lack authority in the Horse Protection...

  14. 22 CFR 91.1 - Answering inquiries regarding tariff acts and customs regulations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Answering inquiries regarding tariff acts and customs regulations. 91.1 Section 91.1 Foreign Relations DEPARTMENT OF STATE LEGAL AND RELATED SERVICES... matters upon which hey are not competent to pass....

  15. Guidance document publications list - Office of Environmental Policy and Assistance RCRA/CERCLA Division (EH-413)

    SciTech Connect

    1995-08-01

    This document provides a listing of Guidance Documents from the RCRA/CERCLA Division for August 1995. Documents are listed under the following categories: RCRA Guidance Manuals; RCRA Information Briefs; CERCLA Guidance Manuals; CERCLA Regulatory Bulletins; RCRA/CERCLA Guidance Manuals; TSCA Guidance Manuals; TSCA Information Briefs; and, Cross Cut Manuals.

  16. Results of RCRA groundwater quality assessment at the 216-B-3 Pond Facility

    SciTech Connect

    Barnett, D.B.; Teel, S.S.

    1997-06-01

    This document describes a groundwater quality assessment of the 216-B-3 pond system, a Resources Conservation and Recovery act of 1976 (RCRA) waste facility. In 1990, sampling and chemical analysis of groundwater underlying the facility indicated that the contamination indicator parameters, total organic halogens (TOX), and total organic carbon (TOC) had exceeded established limits in two wells. This discovery placed the facility into RCRA groundwater assessment status and subsequently led to a more detailed hydrochemical analysis of groundwater underlying the facility. Comprehensive chemical analyses of groundwater samples from 1994 through 1996 revealed one compound, tris (2-chloroethyl) phosphate (TRIS2CH), that may have contributed to elevated TOX concentrations. No compound was identified as a contributor to TOC. Detailed evaluations of TOX, TOC, and TRIS2CH and comparison of occurrences of these parameters led to conclusions that (1) with few exceptions, these constituents occur at low concentrations below or near limits of quantitation; (2) it is problematic whether the low concentrations of TRIS2CH represent a contaminant originating from the facility or if it is a product of well construction; and (3) given the low and diminishing concentration of TOX, TOC, and TRIS2CH, no further investigation into the occurrent of these constituents is justified. Continued groundwater monitoring should include an immediate recalculation of background critical means of upgradient/downgradient comparisons and a return to seminannual groundwater monitoring under a RCRA indicator parameter evaluation program.

  17. Fall Semiannual Report for the HWMA/RCRA Post Closure Permit for the INTEC Waste Calcining Facility at the INL Site

    SciTech Connect

    D. F. Gianotto N. C. Hutten

    2007-01-12

    The Waste Calcining Facility (WCF) is located at the Idaho Nuclear Technology and Engineering Center. In 1998, the WCF was closed under an approved Hazardous Waste Management Act/Resource Conservation and Recovery Act (HWMA/RCRA) Closure Plan. Vessels and spaces were grouted and then covered with a concrete cap. The Idaho Department of Environmental Quality issued a final HWMA/RCRA post-closure permit on September 15, 2003, with an effective date of October 16, 2003. This permit sets forth procedural requirements for groundwater characterization and monitoring, maintenance, and inspections of the WCF to ensure continued protection of human health and the environment.

  18. The Integration of the 241-Z Building Decontamination and Decommissioning Under Cercla with RCRA Closure at the Plutonium Finishing Plant

    SciTech Connect

    Mattlin, E.; Charboneau, S.; Johnston, G.; Hopkins, A.; Bloom, R.; Skeels, B.; Klos, D.B.

    2007-07-01

    The 241-Z treatment and storage tanks, a hazardous waste Treatment, Storage and Disposal (TSD) unit permitted pursuant to the Resource Conservation and Recovery Act of 1976 (RCRA) and Washington State Hazardous Waste Management Act, RCW 70.105, , have been deactivated and are being actively decommissioned under the provisions of the Hanford Federal Facility Agreement and Consent Order (HFFACO), RCRA and Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) 42 U.S.C. 9601 et seq. The 241-Z TSD unit managed non-listed radioactive contaminated waste water, containing trace RCRA characteristic constituents. The 241-Z TSD unit consists of below grade tanks (D-4, D-5, D-7, D-8, and an overflow tank) located in a concrete containment vault, sample glovebox GB-2-241-ZA, and associated ancillary piping and equipment. The tank system is located beneath the 241-Z building. The 241-Z building is not a portion of the TSD unit. The sample glovebox is housed in the above-grade building. Waste managed at the TSD unit was received via underground piping from Plutonium Finishing Plant (PFP) sources. Tank D-6, located in the D-6 vault cell, is a past-practice tank that was taken out of service in 1972 and has never operated as a portion of the RCRA TSD unit. CERCLA actions will address Tank D-6, its containment vault cell, and soil beneath the cell that was potentially contaminated during past-practice operations and any other potential past-practice contamination identified during 241-Z closure, while outside the scope of the Hanford Facility Dangerous Waste Closure Plan, 241-Z Treatment and Storage Tanks. Under the RCRA closure plan, the 241-Z TSD unit is anticipated to undergo clean closure to the performance standards of the State of Washington with respect to dangerous waste contamination from RCRA operations. The TSD unit will be clean closed if physical closure activities identified in the plan achieve clean closure standards for all 241-Z

  19. Industry invites regulation: the passage of the Pure Food and Drug Act of 1906.

    PubMed

    Barkan, I D

    1985-01-01

    Ending its 27-year stranglehold on proposals for federal pure food and drug legislation, Congress passed the Pure Food and Drug Act and its companion bill, the Meat Inspection Act, on June 30, 1906. An unprecedented convergence of consumer, scientific, and industrial support in 1906 prompted such action; most industries even planned for it, hoping regulation would restore the competitiveness of their products on weak foreign and domestic markets. The ways in which these interests converged, and the reasons therefore, suggest a change in their relationships to each other and with the federal government as America headed into the twentieth century. PMID:3881052

  20. Industry invites regulation: the passage of the Pure Food and Drug Act of 1906.

    PubMed Central

    Barkan, I D

    1985-01-01

    Ending its 27-year stranglehold on proposals for federal pure food and drug legislation, Congress passed the Pure Food and Drug Act and its companion bill, the Meat Inspection Act, on June 30, 1906. An unprecedented convergence of consumer, scientific, and industrial support in 1906 prompted such action; most industries even planned for it, hoping regulation would restore the competitiveness of their products on weak foreign and domestic markets. The ways in which these interests converged, and the reasons therefore, suggest a change in their relationships to each other and with the federal government as America headed into the twentieth century. Images p21-a p21-b PMID:3881052

  1. New paradigms for conserved, multifactorial, cis-acting regulation of meiotic recombination.

    PubMed

    Wahls, Wayne P; Davidson, Mari K

    2012-11-01

    How do cells position the Spo11 (Rec12)-dependent initiation of meiotic recombination at hotspots? The mechanisms are poorly understood and a prevailing view is that they differ substantially between phylogenetic groups. However, recent work discovered that individual species have multiple different DNA sequence-specific, protein-DNA complexes that regulate (and are essential for the activation of) recombination hotspots. The cis-acting elements function combinatorially with documented examples of synergism, antagonism and redundancy. Furthermore, we provide evidence that all currently well-defined modules of this multifactorial, cis-acting regulation are conserved functionally between taxa whose latest common ancestor occurred more than 1 billion years ago. Functionally conserved components include the ATF/CREB-family heterodimer Atf1-Pcr1 and its CRE-like DNA site M26, the CCAAT-box-binding complex Php2-Php3-Php5 and the CCAAT-box, and the zinc-finger protein Rst2 and its Oligo-C motif. The newfound multiplicity, functional redundancy and conservation of cis-acting controls constitute a paradigm shift with broad implications. They provide compelling evidence that most meiotic recombination is, like transcription, regulated by sequence-specific protein-DNA complexes. And the new findings provide important mechanistic insight, such as a solution to the conundrum that Prdm9 is a 'master regulator' of--yet is dispensable for--hotspot activity in mammals. PMID:22904082

  2. The Maharashtra Felling of Trees (Regulation) (Amendment) Act, 1988 (No. 26 of 1989), 5 August 1989.

    PubMed

    1989-01-01

    Among other things, this Act amends the Maharashtra (India) Felling of Trees (Regulation) Act, 1964, to authorize the Tree Officer to order the planting of trees in any land (other than government-designated drought land) that he thinks does not contain an adequate number of trees. Owners and occupiers of the land must comply with the order, after being given a reasonable opportunity to be heard. If they do not comply, they can be charged for expenses incurred in having the trees planted. In 1989 the government of West Bengal enacted The Indian Forest (West Bengal Amendment) Act, 1989 (No. 22 of 1988) (Calcutta Gazette, Extraordinary, Part III, 3 February 1989). This Act increases the punishment for various infractions of the Indian Forest Act, 1927, as applied to West Bengal and inserts new language relating to the power of officers to stop and search vehicles; the ability of the state government to seize contraband and related tools, vehicles, boats, and cattle; and punishment for abetting offenses delineated by the Act. PMID:12344326

  3. 26 CFR 1.706-2T - Temporary regulations; question and answer under the Tax Reform Act of 1984.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Temporary regulations; question and answer under the Tax Reform Act of 1984. 1.706-2T Section 1.706-2T Internal Revenue INTERNAL REVENUE SERVICE...-2T Temporary regulations; question and answer under the Tax Reform Act of 1984. Question 1:...

  4. 26 CFR 18.0 - Effective date of temporary regulations under the Subchapter S Revision Act of 1982.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 14 2014-04-01 2013-04-01 true Effective date of temporary regulations under the Subchapter S Revision Act of 1982. 18.0 Section 18.0 Internal Revenue INTERNAL REVENUE SERVICE... SUBCHAPTER S REVISION ACT OF 1982 § 18.0 Effective date of temporary regulations under the Subchapter...

  5. 26 CFR 18.0 - Effective date of temporary regulations under the Subchapter S Revision Act of 1982.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 14 2012-04-01 2012-04-01 false Effective date of temporary regulations under the Subchapter S Revision Act of 1982. 18.0 Section 18.0 Internal Revenue INTERNAL REVENUE SERVICE... SUBCHAPTER S REVISION ACT OF 1982 § 18.0 Effective date of temporary regulations under the Subchapter...

  6. 78 FR 45842 - Amendments to the 2013 Mortgage Rules Under the Real Estate Settlement Procedure Act (Regulation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-30

    ... From the Federal Register Online via the Government Publishing Office BUREAU OF CONSUMER FINANCIAL PROTECTION 12 CFR Parts 1024 and 1026 RIN 3170-AA37 Amendments to the 2013 Mortgage Rules Under the Real Estate Settlement Procedure Act (Regulation X) and the Truth in Lending Act (Regulation Z) Correction...

  7. RCRA implementation plan (RIP): Fiscal years 1996--1997

    SciTech Connect

    1995-05-01

    The report defines the national policy and strategic goals and priority activities for the RCRA solid and hazardous waste program. Includes both changes and clarifications to the fiscal year 1994 RCRA implementation plan and the fiscal year 1995 addendum. It provides additional guidance in waste minimization, corrective action, state grants, beginning of the year plans, Indian programs, environmental justice, information management, state authorization, permitting/closure, and subtitle D activities.

  8. New paradigms for conserved, multifactorial, cis-acting regulation of meiotic recombination

    PubMed Central

    Wahls, Wayne P.; Davidson, Mari K.

    2012-01-01

    How do cells position the Spo11 (Rec12)-dependent initiation of meiotic recombination at hotspots? The mechanisms are poorly understood and a prevailing view is that they differ substantially between phylogenetic groups. However, recent work discovered that individual species have multiple different DNA sequence-specific, protein–DNA complexes that regulate (and are essential for the activation of) recombination hotspots. The cis-acting elements function combinatorially with documented examples of synergism, antagonism and redundancy. Furthermore, we provide evidence that all currently well-defined modules of this multifactorial, cis-acting regulation are conserved functionally between taxa whose latest common ancestor occurred more than 1 billion years ago. Functionally conserved components include the ATF/CREB-family heterodimer Atf1-Pcr1 and its CRE-like DNA site M26, the CCAAT-box-binding complex Php2-Php3-Php5 and the CCAAT-box, and the zinc-finger protein Rst2 and its Oligo-C motif. The newfound multiplicity, functional redundancy and conservation of cis-acting controls constitute a paradigm shift with broad implications. They provide compelling evidence that most meiotic recombination is, like transcription, regulated by sequence-specific protein–DNA complexes. And the new findings provide important mechanistic insight, such as a solution to the conundrum that Prdm9 is a ‘master regulator’ of—yet is dispensable for—hotspot activity in mammals. PMID:22904082

  9. Title III list of lists: Consolidated list of chemicals subject to the Emergency Planning and Community Right-to-Know Act (EPCRA) and section 112(r) of the Clean Air Act, as ammended. Title III of the Superfund Amendments and Reauthorization Act of 1986, and Title III of the Clean Air Act Amendments of 1990, April 1995

    SciTech Connect

    1995-04-01

    This consolidated list has been prepared to help firms handling chemicals determine whether they need to submit reports under sections 302, 304, or 313 of SARA Title III (EPCRA) and, for a specific chemical, what reports may need to be submitted. It will also help firms determine whether they will be subject to accident prevention regulations under CAA section 112(r). Separate lists are also provided of Resource Conservation and Recovery Act (RCRA) waste streams and unlisted hazardous wastes, and of radionuclides reportable under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). These lists should be used as a reference tool, not as a definitive source of compliance information.

  10. 21 CFR 1271.10 - Are my HCT/P's regulated solely under section 361 of the PHS Act and the regulations in this part...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Are my HCT/P's regulated solely under section 361 of the PHS Act and the regulations in this part, and if so what must I do? 1271.10 Section 1271.10 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) REGULATIONS UNDER CERTAIN OTHER ACTS ADMINISTERED...

  11. HIPAA Mental Health Parity Act--IRS. Notice of proposed rulemaking by cross-reference to temporary regulations.

    PubMed

    1997-12-22

    Elsewhere in this issue of the Federal Register, the IRS is issuing temporary regulations relating to mental health parity requirements imposed on group health plans. These requirements were added to the Internal Revenue Code by section 1532 of the Taxpayer Relief Act of 1997. The IRS is issuing the temporary regulations at the same time that the Pension and Welfare Benefits Administration of the U.S. Department of Labor and the Health Care Financing Administration of the U.S. Department of Health and Human Services are issuing substantially similar interim final regulations relating to mental health parity requirements added by the Mental Health Parity Act of 1996 to the Employee Retirement Income Security Act of 1974 and the Public Health Service Act. The temporary regulations provide guidance to employers and group health plans relating to the new mental health parity requirements. The text of those temporary regulations also serves as the text of these proposed regulations.

  12. USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase

    PubMed Central

    Fan, Yihui; Mao, Renfang; Yu, Yang; Liu, Shangfeng; Shi, Zhongcheng; Cheng, Jin; Zhang, Huiyuan; An, Lei; Zhao, Yanling; Xu, Xin; Chen, Zhenghu; Kogiso, Mari; Zhang, Dekai; Zhang, Hong; Zhang, Pumin; Jung, Jae U.; Li, Xiaonan

    2014-01-01

    Lys63-linked polyubiquitination of RIG-I is essential in antiviral immune defense, yet the molecular mechanism that negatively regulates this critical step is poorly understood. Here, we report that USP21 acts as a novel negative regulator in antiviral responses through its ability to bind to and deubiquitinate RIG-I. Overexpression of USP21 inhibited RNA virus–induced RIG-I polyubiquitination and RIG-I–mediated interferon (IFN) signaling, whereas deletion of USP21 resulted in elevated RIG-I polyubiquitination, IRF3 phosphorylation, IFN-α/β production, and antiviral responses in MEFs in response to RNA virus infection. USP21 also restricted antiviral responses in peritoneal macrophages (PMs) and bone marrow–derived dendritic cells (BMDCs). USP21-deficient mice spontaneously developed splenomegaly and were more resistant to VSV infection with elevated production of IFNs. Chimeric mice with USP21-deficient hematopoietic cells developed virus-induced splenomegaly and were more resistant to VSV infection. Functional comparison of three deubiquitinases (USP21, A20, and CYLD) demonstrated that USP21 acts as a bona fide RIG-I deubiquitinase to down-regulate antiviral response independent of the A20 ubiquitin-editing complex. Our studies identify a previously unrecognized role for USP21 in the negative regulation of antiviral response through deubiquitinating RIG-I. PMID:24493797

  13. Report for the HWMA/RCRA Post Closure Permit for the INTEC Waste Calcining Facility at the INL Site

    SciTech Connect

    Idaho Cleanup Project

    2006-06-01

    The Waste Calcining Facility (WCF) is located at the Idaho Nuclear Technology and Engineering Center. In 1998, the WCF was closed under an approved Hazardous Waste Management Act/Resource Conservation and Recovery Act (HWMA/RCRA) Closure Plan. Vessels and spaces were grouted and then covered with a concrete cap. The Idaho Department of Environmental Quality issued a final HWMA/RCRA post-closure permit on September 15, 2003, with an effective date of October 16, 2003. This permit sets forth procedural requirements for groundwater characterization and monitoring, maintenance, and inspections of the WCF to ensure continued protection of human health and the environment. The post-closure permit also includes semiannual reporting requirements under Permit Conditions III.H. and I.U. These reporting requirements have been combined into this single semiannual report.

  14. Risk adjustment under the Affordable Care Act: a guide for federal and state regulators.

    PubMed

    Hall, Mark A

    2011-05-01

    To achieve the aims of the Affordable Care Act, state and federal regulators must construct an effective system of risk adjustment, one that protects health insurers that attract a disproportionate share of patients with poor health risks. This brief, which summarizes a Commonwealth Fund–supported conference of leading risk adjustment experts, explores the challenges regulators will face, considers the consequences of the law's risk adjustment provisions, and analyzes the merits of different risk adjustment strategies. Among other recommendations, the brief suggests that regulators use diagnostic rather than only demographic risk measures, that they allow states some but limited flexibility to tailor risk adjustment methods to local circumstances, and that they phase in the use of risk transfer payments to give insurers more time to predict and understand the full effects of risk adjustment.

  15. Regulation of toxic pollutants under the Clean Water Act: EPA's ten-year rulemaking nears completion

    SciTech Connect

    Wyche, B.W.

    1983-01-01

    Whether it's footdragging, or compliance is impossible, the Environmental Protection Agency (EPA) usually fails to meet its deadlines for issuing regulations. The best-known case is probably EPA's 10-year struggle to establish regulatory controls on toxic pollutants under the Clean Water Act. The developmental process is reviewed from the initial statutory framework (enacted in 1948) and the effluent limitations amendments (legislated in 1972), through its litigation history, to an analysis of the federal district court's three substantive opinions delivered during 1982. The author considers the possibility of legislative intervention because deadlines for compliance have been issued but the regulations have not. He concludes that without Toxics Consent Decree litigation, the toxic pollutant control program might have become a reality. EPA's toxic pollutant control regulations as of April 1, 1983, are tabulated. 129 references, 4 tables.

  16. 78 FR 13298 - Notice of Retrospective Review of the Americans With Disabilities Act Regulations for Over-the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-27

    ... Statement in the Federal Register published on April 11, 2000 (65 FR 19477). FOR FURTHER INFORMATION CONTACT... Act Regulations for Over-the-Road Bus Operators; Request for Comments AGENCY: Office of the Secretary...) implementing regulations for over-the-road bus (OTRB) operators. The DOT will review regulations specified...

  17. ATH1 and KNAT2 proteins act together in regulation of plant inflorescence architecture.

    PubMed

    Li, Yang; Pi, Limin; Huang, Hai; Xu, Lin

    2012-02-01

    The inflorescence of flowering plants is a highly organized structure, not only contributing to plant reproductive processes, but also constituting an important part of the entire plant morphology. Previous studies have revealed that the class-I KNOTTED1-like homeobox (KNOX) genes BREVIPEDICELLUS (BP or KNAT1), KNAT2, and KNAT6 play essential roles in inflorescence architecture. Pedicel morphology is known to contribute greatly to inflorescence architecture, and BP negatively regulates KNAT2 and KNAT6 to ensure that pedicels have a normal upward-pointing orientation. These findings indicate that a genetic network exists in controlling pedicel orientation, but how this network functions in the developmental process remains elusive. Here it is reported that the ARABIDOPSIS THALIANA HOMEOBOX GENE1 (ATH1) gene, which belongs to the BELL1-like homeodomain gene family, is a new member participating in regulating pedicel orientation in the class-I KNOX network. In a genetic screening for suppressors of isoginchaku-2D, a gain-of-function ASYMMETRIC LEAVES2 mutant that displays downward-pointing pedicels, a suppressor mutant was obtained. Characterization of this mutant revealed that the mutation corresponds to ATH1. Genetic analysis indicated that ATH1 acts mainly in the KNAT2 pathway. Yeast two-hybrid and bimolecular fluorescence complementation assays demonstrated that ATH1 physically interacts with KNAT2. The data indicate that the ATH1-KNAT2 complex acts redundantly with KNAT6, both of which are negatively regulated by BP during pedicel development.

  18. RCRA, superfund and EPCRA hotline training module. Introduction to: Groundwater monitoring (40 cfr parts 264/265, subpart f) updated July 1996

    SciTech Connect

    1996-07-01

    The module presents the requirements for groundwater monitoring at interim status and permitted treatment, storage, and disposal facilities (TSDFs) under the Resource Conservation and Recovery Act (RCRA). The goal of the module is to explain the standards and specific requirements for groundwater monitoring programs at interim status and permitted facilities.

  19. Nuclear power meets the 101st Congress, a {open_quotes}one-act{close_quotes} comedy: Regulation of Nuclear Regulatory Commission licensees under the Clean Air Act

    SciTech Connect

    Goldsmith, R.

    1992-12-31

    In the Clean Air Act Amendments of 1977, Congress directed the Environmental Protection Agency (EPA) to regulate all radioactive pollutants, including those emitted from facilities licensed and regulated under the Atomic Energy Act (AEA) by the Nuclear Regulatory Commission (NRC). Thus began the era of so-called {open_quotes}dual regulation.{close_quotes} Thirteen years later, that era ended with the passage of section 112(d)(9) of the Clean Air Act Amendments of 1990, which authorized the EPA to refrain from regulating any category of NRC-licensed facility if it found that NRC regulation was adequate to protect public health. This story of how Congress reversed regulatory policy is actually a story more about nuclear power than air pollution. Dual regulation was authorized in 1977 because of two concerns: fears about the public health risks associated with the nation`s growing commitment to nuclear power and doubts about the integrity of nuclear regulation by the NRC. Although neither of these concerns had abated by 1990, the legislative process was so adroitly manipulated by the proponents of nuclear power that Congress, unwittingly, restored the NRC`s regulatory monopoly.

  20. The Arabidopsis LYST INTERACTING PROTEIN 5 Acts in Regulating Abscisic Acid Signaling and Drought Response.

    PubMed

    Xia, Zongliang; Huo, Yongjin; Wei, Yangyang; Chen, Qiansi; Xu, Ziwei; Zhang, Wei

    2016-01-01

    Multivesicular bodies (MVBs) are unique endosomes containing vesicles in the lumens and play essential roles in many eukaryotic cellular processes. The Arabidopsis LYST INTERACTING PROTEIN 5 (LIP5), a positive regulator of MVB biogenesis, has critical roles in biotic and abiotic stress responses. However, whether the abscisic acid (ABA) signaling is involved in LIP5-mediated stress response is largely unknown. Here, we report that LIP5 functions in regulating ABA signaling and drought response in Arabidopsis. Analyses of a LIP5 promoter-β-glucuronidase (GUS) construct revealed substantial GUS activity in whole seedlings. The expression of LIP5 was induced by ABA and drought, and overexpression of LIP5 led to ABA hypersensitivity, enhanced stomatal closure, reduced water loss, and, therefore, increased drought tolerance. On the contrary, LIP5 knockdown mutants showed ABA-insensitive phenotypes and reduced drought tolerance; suggesting that LIP5 acts in regulating ABA response. Further analysis using a fluorescent dye revealed that ABA and water stress induced cell endocytosis or vesicle trafficking in a largely LIP5-dependent manner. Furthermore, expression of several drought- or ABA-inducible marker genes was significantly down-regulated in the lip5 mutant seedlings. Collectively, our data suggest that LIP5 positively regulates drought tolerance through ABA-mediated cell signaling. PMID:27313589

  1. The Arabidopsis LYST INTERACTING PROTEIN 5 Acts in Regulating Abscisic Acid Signaling and Drought Response

    PubMed Central

    Xia, Zongliang; Huo, Yongjin; Wei, Yangyang; Chen, Qiansi; Xu, Ziwei; Zhang, Wei

    2016-01-01

    Multivesicular bodies (MVBs) are unique endosomes containing vesicles in the lumens and play essential roles in many eukaryotic cellular processes. The Arabidopsis LYST INTERACTING PROTEIN 5 (LIP5), a positive regulator of MVB biogenesis, has critical roles in biotic and abiotic stress responses. However, whether the abscisic acid (ABA) signaling is involved in LIP5-mediated stress response is largely unknown. Here, we report that LIP5 functions in regulating ABA signaling and drought response in Arabidopsis. Analyses of a LIP5 promoter-β-glucuronidase (GUS) construct revealed substantial GUS activity in whole seedlings. The expression of LIP5 was induced by ABA and drought, and overexpression of LIP5 led to ABA hypersensitivity, enhanced stomatal closure, reduced water loss, and, therefore, increased drought tolerance. On the contrary, LIP5 knockdown mutants showed ABA-insensitive phenotypes and reduced drought tolerance; suggesting that LIP5 acts in regulating ABA response. Further analysis using a fluorescent dye revealed that ABA and water stress induced cell endocytosis or vesicle trafficking in a largely LIP5-dependent manner. Furthermore, expression of several drought- or ABA-inducible marker genes was significantly down-regulated in the lip5 mutant seedlings. Collectively, our data suggest that LIP5 positively regulates drought tolerance through ABA-mediated cell signaling. PMID:27313589

  2. Identification of trans-acting factors regulating SamDC expression in Oryza sativa

    SciTech Connect

    Basu, Supratim; Roychoudhury, Aryadeep; Sengupta, Dibyendu N.

    2014-03-07

    Highlights: • Identification of cis elements responsible for SamDC expression by in silico analysis. • qPCR analysis of SamDC expression to abiotic and biotic stress treatments. • Detection of SamDC regulators using identified cis-elements as probe by EMSA. • Southwestern Blot analysis to predict the size of the trans-acting factors. - Abstract: Abiotic stress affects the growth and productivity of crop plants; to cope with the adverse environmental conditions, plants have developed efficient defense machinery comprising of antioxidants like phenolics and flavonoids, and osmolytes like polyamines. SamDC is a key enzyme in the polyamine biosynthesis pathway in plants. In our present communication we have done in silico analysis of the promoter region of SamDC to look for the presence of different cis-regulatory elements contributing to its expression. Based on the presence of different cis-regulatory elements we completed comparative analysis of SamDC gene expression in rice lamina of IR-29 and Nonabokra by qPCR in response to the abiotic stress treatments of salinity, drought, cold and the biotic stress treatments of ABA and light. Additionally, to explore the role of the cis-regulatory elements in regulating the expression of SamDC gene in plants we comparatively analyzed the binding of rice nuclear proteins prepared from IR-29 and Nonabokra undergoing various stress treatments. The intensity of the complex formed was low and inducible in IR-29 in contrast to Nonabokra. Southwestern blot analysis helped in predicting the size of the trans-acting factors binding to these cis-elements. To our knowledge this is the first report on the comprehensive analysis of SamDC gene expression in rice and identification of the trans-acting factors regulating its expression.

  3. Safety regulation and firm size: effects of the Coal Mine Health and Safety Act of 1969

    SciTech Connect

    Neumann, G.R.; Nelson, J.P.

    1982-10-01

    The Coal Mine Health and Safety Act of 1969 has contributed to the decline in mine productivity, which must be weighed against safer working conditions for the miners. There may be some overstatement of the benefits if only fatalities are considered, however, because there was an increase in non-fatal accidents after 1970. Safety regulations have forced the closure of some small mines and raised some questions about the tradeoffs necessary when work safety reduces competition. A review of pertinent legislation, a hedonic wage-differential model, and the effects of union wage policy are applied to these questions. 4 tables. (DCK)

  4. Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly

    PubMed Central

    Lettice, Laura A.; Horikoshi, Taizo; Heaney, Simon J. H.; van Baren, Marijke J.; van der Linde, Herma C.; Breedveld, Guido J.; Joosse, Marijke; Akarsu, Nurten; Oostra, Ben A.; Endo, Naoto; Shibata, Minoru; Suzuki, Mikio; Takahashi, Eiichi; Shinka, Toshikatsu; Nakahori, Yutaka; Ayusawa, Dai; Nakabayashi, Kazuhiko; Scherer, Stephen W.; Heutink, Peter; Hill, Robert E.; Noji, Sumihare

    2002-01-01

    Preaxial polydactyly (PPD) is a common limb malformation in human. A number of polydactylous mouse mutants indicate that misexpression of Shh is a common requirement for generating extra digits. Here we identify a translocation breakpoint in a PPD patient and a transgenic insertion site in the polydactylous mouse mutant sasquatch (Ssq). The genetic lesions in both lie within the same respective intron of the LMBR1/Lmbr1 gene, which resides ≈1 Mb away from Shh. Genetic analysis of Ssq reveals that the Lmbr1 gene is incidental to the phenotype and that the mutation directly interrupts a cis-acting regulator of Shh. This regulator is most likely the target for generating PPD mutations in human. PMID:12032320

  5. Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly.

    PubMed

    Lettice, Laura A; Horikoshi, Taizo; Heaney, Simon J H; van Baren, Marijke J; van der Linde, Herma C; Breedveld, Guido J; Joosse, Marijke; Akarsu, Nurten; Oostra, Ben A; Endo, Naoto; Shibata, Minoru; Suzuki, Mikio; Takahashi, Eiichi; Shinka, Toshikatsu; Nakahori, Yutaka; Ayusawa, Dai; Nakabayashi, Kazuhiko; Scherer, Stephen W; Heutink, Peter; Hill, Robert E; Noji, Sumihare

    2002-05-28

    Preaxial polydactyly (PPD) is a common limb malformation in human. A number of polydactylous mouse mutants indicate that misexpression of Shh is a common requirement for generating extra digits. Here we identify a translocation breakpoint in a PPD patient and a transgenic insertion site in the polydactylous mouse mutant sasquatch (Ssq). The genetic lesions in both lie within the same respective intron of the LMBR1/Lmbr1 gene, which resides approximately 1 Mb away from Shh. Genetic analysis of Ssq reveals that the Lmbr1 gene is incidental to the phenotype and that the mutation directly interrupts a cis-acting regulator of Shh. This regulator is most likely the target for generating PPD mutations in human.

  6. The European "clinical trial" regulation; relationship with the Jardé Act: a Giens workshop.

    PubMed

    Lemaire, François; Marchenay, Brigitte; Chassany, Olivier; Barthélémy, Philippe; Bouzzagou, Mohamed; Comet, Denis; Delval, Cécile; Dubray, Claude; Fouret, Cécile; Frija-Orvoen, Elisabeth; Gambotti, Laetitia; Lamarque, Véronique; d'Orsay, Geneviève; Plattner, Valérie; Sibenaler, Claire; Roux, Jacques; Thoby, Frédérique

    2015-01-01

    In May 2014, the European Union Parliament and Council published a new regulation on clinical trials on medicinal products for human use, which is designed to replace Directive 2001/20/EC. It will not come into effect until 2016. Nevertheless, it is essential to examine its relationship with national legislation, i.e. the Jardé Act, whose implementation has been delayed pending publication of the European regulation. The Giens workshop identified and examined the various issues that this relationship is bound to raise. In particular, it looked at trial methodology assessment procedures, the working relationship between the French National Agency of Drug Safety and Health Products (Agence Nationale de Sécurité du Médicament et des Produits de Santé, ANSM) and ethics committees during the authorization application evaluation phase, review of post-authorization/registration studies on medicinal products and medical devices, and data transparency.

  7. An example of system integration for RCRA policy analysis

    SciTech Connect

    Tonn, B.; Goeltz, R. ); Schmidt, K. )

    1991-01-01

    This paper describes the synthesis of various computer technologies and software systems used on a project to estimate the costs of remediating Solid Waste Management Units (SWMUs) that fall under the corrective action provisions of the Resource Conservation and Recovery Act (RCRA). The project used two databases collected by Research Triangle Institute (RTI) that contain information on SWMUs and a PC-based software system called CORA that develops cost estimates for remediating SWMUs. The project team developed rules to categorize every SWMU in the databases by the kinds of technologies required to clean them up. These results were input into CORA, which estimated costs associated with the technologies. Early on, several computing challenges presented themselves. First, the databases have several hundred thousand records each. Second, the categorization rules could not be written to cover all combinations of variables. Third, CORA is run interactively and the analysis plan called for running CORA tens of thousands of times. Fourth, large data transfers needed to take place between RTI and Oak Ridge National Laboratory. Solutions to these problems required systems integration. SWMU categorization was streamlined by using INTERNET as was the data transfer. SAS was used to create files used by a program called SuperKey that was used to run CORA. Because the analysis plan required the generation of hundreds of thousands of cost estimates, memory management software was needed to allow the portable IBM P70 to do the job. During the course of the project, several other software packages were used, including: SAS System for Personal Computers (SAS/PC), DBase III, LOTUS 1-2-3, PIZAZZ PLUS, LOTUS Freelance Plus, and Word Perfect. Only the comprehensive use of all available hardware and software resources allowed this project to be completed within the time and budget constraints. 5 refs., 3 figs., 3 tabs.

  8. Management of hazardous waste at RCRA facilities during the flood of `93 -- Methods used and lessons learned

    SciTech Connect

    Martin, T.; Jacko, R.B.

    1996-11-01

    During the summer of 1993, the state of Iowa experienced severe flooding that caused the release of many hazardous materials into the environment. Six months after the flood, the Iowa section of the RCRA branch, US EPA Region 7, sent inspectors to survey every RCRA facility in Iowa. Information was gathered through questionnaires to determine the flood`s impact and to learn potential lessons that could be beneficial in future flood disasters. The objective of this project was to use the information gathered to determine effective storage methods and emergency procedures for handling hazardous material during flood disasters. Additional data were obtained through record searches, phone interviews, and site visits. Data files and statistics were analyzed, then the evident trends and specific insights observed were utilized to create recommendations for RCRA facilities in the flood plain and for the federal EPA and state regulatory agencies. The recommendations suggest that RCRA regulated facilities in the flood plain should: employ the safest storage methods possible; have a flood emergency plan that includes the most effective release prevention available; and take advantage of several general suggestions for flood protection. The recommendations suggest that the federal EPA and state regulatory agencies consider: including a provision requiring large quantity generators of hazardous waste in the flood plain to include flood procedures in the contingency plans; establishing remote emergency storage areas during the flood disasters; encouraging small quantity generators (SQGs) within the flood plain to establish flood contingency plans; and promoting sound flood protection engineering practices for all RCRA facilities in the flood plain.

  9. Knowledge of the animal welfare act and animal welfare regulations influences attitudes toward animal research.

    PubMed

    Metzger, Mitchell M

    2015-01-01

    Recent public-opinion polls indicate that Americans have shown a decline in support for animal experimentation, and several reports suggest a relationship between people's knowledge of animal welfare regulations and their attitudes toward animal research. Therefore, this study was designed to assess respondent's knowledge of several provisions in the Animal Welfare Act (AWA) and Animal Welfare Regulations (AWR), and determine whether exposure to elements of this legislation would influence an individual's attitudes toward the use of animals in research. A survey was used to assess knowledge of animal research regulations and attitudes toward animal research from a sample of individuals recruited through Amazon's Mechanical Turk crowdsourcing marketplace. Results from study 1 confirmed the hypothesis that respondents had little knowledge of various federal regulations that govern animal research activities. Data from study 2 revealed that exposure to elements of the AWA and AWR influenced participants' attitudes toward the use of animals in research. These results suggest that providing information to the general public about the AWA and AWR that protect laboratory animals from abuse and neglect may help alleviate concerns about using animals in research settings. PMID:25651094

  10. Knowledge of the Animal Welfare Act and Animal Welfare Regulations Influences Attitudes toward Animal Research

    PubMed Central

    2015-01-01

    Recent public-opinion polls indicate that Americans have shown a decline in support for animal experimentation, and several reports suggest a relationship between people's knowledge of animal welfare regulations and their attitudes toward animal research. Therefore, this study was designed to assess respondent's knowledge of several provisions in the Animal Welfare Act (AWA) and Animal Welfare Regulations (AWR), and determine whether exposure to elements of this legislation would influence an individual's attitudes toward the use of animals in research. A survey was used to assess knowledge of animal research regulations and attitudes toward animal research from a sample of individuals recruited through Amazon's Mechanical Turk crowdsourcing marketplace. Results from study 1 confirmed the hypothesis that respondents had little knowledge of various federal regulations that govern animal research activities. Data from study 2 revealed that exposure to elements of the AWA and AWR influenced participants’ attitudes toward the use of animals in research. These results suggest that providing information to the general public about the AWA and AWR that protect laboratory animals from abuse and neglect may help alleviate concerns about using animals in research settings. PMID:25651094

  11. Knowledge of the animal welfare act and animal welfare regulations influences attitudes toward animal research.

    PubMed

    Metzger, Mitchell M

    2015-01-01

    Recent public-opinion polls indicate that Americans have shown a decline in support for animal experimentation, and several reports suggest a relationship between people's knowledge of animal welfare regulations and their attitudes toward animal research. Therefore, this study was designed to assess respondent's knowledge of several provisions in the Animal Welfare Act (AWA) and Animal Welfare Regulations (AWR), and determine whether exposure to elements of this legislation would influence an individual's attitudes toward the use of animals in research. A survey was used to assess knowledge of animal research regulations and attitudes toward animal research from a sample of individuals recruited through Amazon's Mechanical Turk crowdsourcing marketplace. Results from study 1 confirmed the hypothesis that respondents had little knowledge of various federal regulations that govern animal research activities. Data from study 2 revealed that exposure to elements of the AWA and AWR influenced participants' attitudes toward the use of animals in research. These results suggest that providing information to the general public about the AWA and AWR that protect laboratory animals from abuse and neglect may help alleviate concerns about using animals in research settings.

  12. FOXA1 acts upstream of GATA2 and AR in hormonal regulation of gene expression.

    PubMed

    Zhao, J C; Fong, K-W; Jin, H-J; Yang, Y A; Kim, J; Yu, J

    2016-08-18

    Hormonal regulation of gene expression by androgen receptor (AR) is tightly controlled by many transcriptional cofactors, including pioneer factors FOXA1 and GATA2, which, however, exhibit distinct expression patterns and functional roles in prostate cancer. Here, we examined how FOXA1, GATA2 and AR crosstalk and regulate hormone-dependent gene expression in prostate cancer cells. Chromatin immunoprecipitation sequencing analysis revealed that FOXA1 reprograms both AR and GATA2 cistrome by preferably recruiting them to FKHD-containing genomic sites. By contrast, GATA2 is unable to shift AR or FOXA1 to GATA motifs. Rather, GATA2 co-occupancy enhances AR and FOXA1 binding to nearby ARE and FKHD sites, respectively. Similarly, AR increases, but not reprograms, GATA2 and FOXA1 cistromes. Concordantly, GATA2 and AR strongly enhance the transcriptional program of each other, whereas FOXA1 regulates GATA2- and AR-mediated gene expression in a context-dependent manner due to its reprogramming effects. Taken together, our data delineated for the first time the distinct mechanisms by which GATA2 and FOXA1 regulate AR cistrome and suggest that FOXA1 acts upstream of GATA2 and AR in determining hormone-dependent gene expression in prostate cancer.

  13. Global regulation of alternative splicing by adenosine deaminase acting on RNA (ADAR)

    PubMed Central

    Solomon, Oz; Oren, Shirley; Safran, Michal; Deshet-Unger, Naamit; Akiva, Pinchas; Jacob-Hirsch, Jasmine; Cesarkas, Karen; Kabesa, Reut; Amariglio, Ninette; Unger, Ron; Rechavi, Gideon; Eyal, Eran

    2013-01-01

    Alternative mRNA splicing is a major mechanism for gene regulation and transcriptome diversity. Despite the extent of the phenomenon, the regulation and specificity of the splicing machinery are only partially understood. Adenosine-to-inosine (A-to-I) RNA editing of pre-mRNA by ADAR enzymes has been linked to splicing regulation in several cases. Here we used bioinformatics approaches, RNA-seq and exon-specific microarray of ADAR knockdown cells to globally examine how ADAR and its A-to-I RNA editing activity influence alternative mRNA splicing. Although A-to-I RNA editing only rarely targets canonical splicing acceptor, donor, and branch sites, it was found to affect splicing regulatory elements (SREs) within exons. Cassette exons were found to be significantly enriched with A-to-I RNA editing sites compared with constitutive exons. RNA-seq and exon-specific microarray revealed that ADAR knockdown in hepatocarcinoma and myelogenous leukemia cell lines leads to global changes in gene expression, with hundreds of genes changing their splicing patterns in both cell lines. This global change in splicing pattern cannot be explained by putative editing sites alone. Genes showing significant changes in their splicing pattern are frequently involved in RNA processing and splicing activity. Analysis of recently published RNA-seq data from glioblastoma cell lines showed similar results. Our global analysis reveals that ADAR plays a major role in splicing regulation. Although direct editing of the splicing motifs does occur, we suggest it is not likely to be the primary mechanism for ADAR-mediated regulation of alternative splicing. Rather, this regulation is achieved by modulating trans-acting factors involved in the splicing machinery. PMID:23474544

  14. 76 FR 39007 - Native American Graves Protection and Repatriation Act Regulations- Definition of “Indian Tribe”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-05

    ... Office of the Secretary of the Interior 43 CFR Part 10 RIN 1024-AD98 Native American Graves Protection... regulations implementing the Native American Graves Protection and Repatriation Act (NAGPRA) removes the... implementation of the Native American Graves Protection and Repatriation Act, including the issuance...

  15. RCRA Facility Investigation Plan K-1004 Area Lab Drain and the K-1007-B Pond - Oak Ridge Gaseous Diffusion Plant - Oak Ridge, Tennessee

    SciTech Connect

    ORGDP, Martin Marietta Energy Systems Inc.

    1988-12-01

    Within the confines of the Oak Ridge Gaseous Diffusion Plant (ORGDP) are hazardous waste treatment, storage, and disposal facilities; some are in operation while others are no longer in use. these solid waste management units (SWMUs) are subject to assessment by the US Environmental Protection Agency (EPA). The RCRA Facility Investigation (RFI) Plans are scheduled to be submitted for all units during calendar years 1987 and 1988. The RFI Plan - General Document (K/HS-132) includes information applicable to all the ORGDP SMWUs and serves as a reference document for the site-specific RFI plans. This document is the site-specific RFI Plan for the K-1004 Area Lab Drain (ALD) and the K-1007-B Pond. This plan is based upon requirements described in the draft document, RFI Guidance, Vols. I-IV, December 1987 (EPA 530/SW-87-001). This unit is regulated by Section 3004(u) of the 1984 Hazardous and Solid Waste Amendments (HSWA) to the Resource Conservation Recovery Act (RCRA). Contained within this document are geographical, historical, operational, geological, and hydrological data specific to the K-1004 ALD and the K-1007-B Pond. The potential for release of contamination through the various media to receptors is addressed. A sampling plan is proposed to further determine the extent (if any) of release of contamination to the surrounding environment. Included are health and safety procedures to be followed when implementing the sampling plan. Quality control (QC) procedures for remedial action occurring on the Oak Ridge Reservation (ORR) are presented in 'The Environmental Surveillance Procedures Quality Control Program, Martin Marietta Energy Systems, Inc., (ESH/Sub/87-21706/1), and quality assurance (QA) guidelines for ORGDP investigations are contained in The K-25 Remedial Actions Program Quality Assurance Plan, K/HS-231.

  16. Confinement regulates complex biochemical networks: initiation of blood clotting by "diffusion acting".

    PubMed

    Shen, Feng; Pompano, Rebecca R; Kastrup, Christian J; Ismagilov, Rustem F

    2009-10-21

    This study shows that environmental confinement strongly affects the activation of nonlinear reaction networks, such as blood coagulation (clotting), by small quantities of activators. Blood coagulation is sensitive to the local concentration of soluble activators, initiating only when the activators surpass a threshold concentration, and therefore is regulated by mass transport phenomena such as flow and diffusion. Here, diffusion was limited by decreasing the size of microfluidic chambers, and it was found that microparticles carrying either the classical stimulus, tissue factor, or a bacterial stimulus, Bacillus cereus, initiated coagulation of human platelet-poor plasma only when confined. A simple analytical argument and numerical model were used to describe the mechanism for this phenomenon: confinement causes diffusible activators to accumulate locally and surpass the threshold concentration. To interpret the results, a dimensionless confinement number, Cn, was used to describe whether a stimulus was confined, and a Damköhler number, Da(2), was used to describe whether a subthreshold stimulus could initiate coagulation. In the context of initiation of coagulation by bacteria, this mechanism can be thought of as "diffusion acting", which is distinct from "diffusion sensing". The ability of confinement and diffusion acting to change the outcome of coagulation suggests that confinement should also regulate other biological "on" and "off" processes that are controlled by thresholds.

  17. RCRA implementation plan: Fiscal year 1995: Addendum containing changes, clarifications, or additions to FY 1994 rip

    SciTech Connect

    1994-07-01

    The report provides additional information to supplement the `RCRA implementation plan: fiscal year 1994`. It describes the objectives and priorities EPA has set for the RCRA program. It also discusses waste minimization, environmental justice, corrective action, and biennial reporting.

  18. RCRA delisting of agent-decontaminated waste and remediation waste at Dugway Proving Ground: A program update

    SciTech Connect

    Kimmell, T.A.; Anderson, A.W.; O`Neill, H.J.

    1996-03-01

    In July 1988, the state of Utah issued regulations that declared residues resulting from the demilitarization, treatment, and testing of military chemical agents to be hazardous wastes. These residues were designated as corrosive, reactive, toxic, and acute hazardous (Hazardous Waste No. F999). These residues are not listed by the U.S. Environmental Protection Agency (EPA) as hazardous waste under the Resource Conservation and Recovery Act (RCRA), which is the primary law governing management of hazardous waste in the United States. The RCRAI regulations (40 CFR 260-280), the Utah Administrative Code (R-315), and other state hazardous waste programs list specific wastes as hazardous but allow generators to petition the regulator to {open_quotes}delist{close_quotes} if it can be demonstrated that such wastes are not hazardous. In 1994, the U.S. Army Test and Evaluation Command FECOM initiated a project with the Argonne National Laboratory (Argonne) to demonstrate that certain categories of F999 residues are not hazardous waste and to achieve delisting. The initial focus is on delisting agent-decontaminated residues and soil with a history of contamination at the U.S. Army Dugway Proving Ground (DPG), Utah. An overview of the DPG delisting program was presented at the 1995 American Defense Preparedness Association Environmental Symposium. Since that time, much progress has been made. The purpose of this paper is to review the DPG delisting program and discuss overall progress. Emphasis is placed on progress with regard to analytical methods that will be used to demonstrate that the target residues do not contain hazardous amounts of chemical agent.

  19. Rocky Flats Solar Evaporation Ponds RCRA hybrid-closure case study

    SciTech Connect

    Ogg, R.T.; Everett, L.G.; Cullen, S.J.

    1995-12-31

    The Solar Evaporation Ponds (SEP)/Operable Unit 4 (OU 4), located at the Rocky Flats Plant (RFP) sixteen miles northwest of Denver, Colorado, is currently undergoing remediation/Resource Conservation and Recovery Act (RCRA) closure in accordance with the Rocky Flats Interagency Agreement (IAG) signed by the US Department of Energy (DOE), US Environmental Protection Agency (EPA) and Colorado Department of Health (CDH) on January 22, 1991. Based on the Phase 1 (source and soils) RCRA Facility Investigation/Remedial Investigation (RFI/RI) data and interpretations, the DOE and EG and G Rocky Flats, Inc. (EG and G) have selected a permanent surface engineered/isolation barrier as the technological option for remediation of the SEP. The DOE and EG and G will utilize all natural materials to create an impermeable barrier/structure to isolate the waste being left in place from impacting human health and the environment for a minimum of 1,000 years. The rationale for utilizing natural materials is two fold; (1) optimize long term performance of the barrier and; (2) design a structure which will be near maintenance free (passive remediation) for 1,000 years. The DOE and EG and G have taken a proactive approach in providing post closure performance assessment for this RCRA closure action. An integrated monitoring system has been designed which will include monitoring the engineered barrier, vadose zone and ground water systems. Rocky Flats will integrate instrumentation, into the permanent engineered barrier which will provide early warning of potential liquid migration through the barrier and into the waste zone.

  20. Rocky Flats Solar Evaporation Ponds RCRA hybrid-closure case study

    SciTech Connect

    Ogg, R.T.; Everett, L.G.; Cullen, S.J.

    1994-12-31

    The Solar Evaporation Ponds (SEP)/Operable Unit 4 (OU 4), located at the Rocky Flats Plant (RFP) sixteen miles northwest of Denver, Colorado, is currently undergoing remediation/Resource Conservation and Recovery Act (RCRA) closure in accordance with the Rocky Flats Interagency Agreement (IAG) signed by the US Department of Energy (DOE), US Environmental Protection Agency (EPA) and Colorado Department of Health (CDH) on January 22, 1991. Based on the ``Phase 1`` (source and soils) RCRA Facility Investigation/Remedial Investigation (RFM data and interpretations), the DOE and EG and G Rocky Flats, Inc. (EG and G) have selected a permanent surface engineered/isolation barrier as the technological option for remediation of the SEP. The DOE and EG and G will utilize all natural materials to create an ``impermeable`` barrier/structure to isolate the waste being left in place from impacting human health and the environment for a minimum of 1,000 years. Their rationale for utilizing natural materials is two fold; (1) optimize long term performance of the barrier and; (2) design a structure which will be near maintenance free (passive remediation) for 1,000 years. The DOE and EG and G have taken a proactive approach in providing post closure performance assessment for this RCRA closure action. An integrated monitoring system has been designed which will include monitoring the engineered barrier, vadose zone and ground water systems. Rocky Flats will integrate instrumentation into the permanent engineered barrier which will provide early warning of potential liquid migration through the barrier and into the waste zone.

  1. Self-assembled monolayers on mosoporous supports (SAMMS) for RCRA metal removal

    SciTech Connect

    Feng, Xiangdong; Liu, Jun; Fryxell, G.

    1997-10-01

    The Mixed Waste Focus Area has declared mercury removal and stabilization as the first and fourth priorities among 30 prioritized deficiencies. Resource Conservation and Recovery Act (RCRA) metal and mercury removal has also been identified as a high priority at DOE sites such as Albuquerque, Idaho Falls, Oak Ridge, Hanford, Rocky Flats, and Savannah River. Under this task, a proprietary new technology, Self-Assembled Monolayers on Mesoporous Supports (SAMMS), for RCRA metal ion removal from aqueous wastewater and mercury removal from organic wastes such as vacuum pump oils is being developed at Pacific Northwest National Laboratory (PNNL). The six key features of the SAMMS technology are (1) large surface area (>900 m{sup 2}/g) of the mesoporous oxides (SiO{sub 2}, ZrO{sub 2}, TiO{sub 2}) ensures high capacity for metal loading (more than 1 g Hg/g SAMMS); (2) molecular recognition of the interfacial functional groups ensures the high affinity and selectivity for heavy metals without interference from other abundant cations (such as calcium and iron) in wastewater; (3) suitability for removal of mercury from both aqueous wastes and organic wastes; (4) the Hg-laden SAMMS not only pass TCLP tests, but also have good long-term durability as a waste form because the covalent binding between mercury and SAMMS has good resistance to ion exchange, oxidation, and hydrolysis; (5) the uniform and small pore size (2 to 40 nm) of the mesoporous silica prevents bacteria (>2000 nm) from solubilizing the bound mercury; and (6) SAMMS can also be used for RCRA metal removal from gaseous mercury waste, sludge, sediment, and soil.

  2. Monitoring Plan for RCRA Groundwater Assessment at the 216-U-12 Crib

    SciTech Connect

    Williams, Bruce A.; Chou, Charissa J.

    2005-09-20

    This document contains a revised and updated monitoring plan for RCRA interim status groundwater assessment, site hydrogeology, and a conceptual model of the RCRA treatment, storage, and disposal unit. Monitoring under interim status is expected to continue until the 216-U-12 crib is incorporated as a chapter into the Hanford Facility RCRA Permit or administratively closed as proposed to EPA and Ecology.

  3. 40 CFR 124.19 - Appeal of RCRA, UIC, NPDES, and PSD Permits.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 22 2011-07-01 2011-07-01 false Appeal of RCRA, UIC, NPDES, and PSD... PROGRAMS PROCEDURES FOR DECISIONMAKING General Program Requirements § 124.19 Appeal of RCRA, UIC, NPDES, and PSD Permits. (a) Within 30 days after a RCRA, UIC, NPDES, or PSD final permit decision (or...

  4. 40 CFR 124.19 - Appeal of RCRA, UIC, NPDES, and PSD Permits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Appeal of RCRA, UIC, NPDES, and PSD... PROGRAMS PROCEDURES FOR DECISIONMAKING General Program Requirements § 124.19 Appeal of RCRA, UIC, NPDES, and PSD Permits. (a) Within 30 days after a RCRA, UIC, NPDES, or PSD final permit decision (or...

  5. 40 CFR 124.19 - Appeal of RCRA, UIC, NPDES, and PSD Permits.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Appeal of RCRA, UIC, NPDES, and PSD... PROGRAMS PROCEDURES FOR DECISIONMAKING General Program Requirements § 124.19 Appeal of RCRA, UIC, NPDES, and PSD Permits. (a) Within 30 days after a RCRA, UIC, NPDES, or PSD final permit decision (or...

  6. Polycomb Group Protein Pcgf6 Acts as a Master Regulator to Maintain Embryonic Stem Cell Identity

    PubMed Central

    Yang, Chao-Shun; Chang, Kung-Yen; Dang, Jason; Rana, Tariq M.

    2016-01-01

    The polycomb repressive complex 1 (PRC1) is a multi-subunit complex that plays critical roles in the epigenetic modulation of gene expression. Here, we show that the PRC1 component polycomb group ring finger 6 (Pcgf6) is required to maintain embryonic stem cell (ESC) identity. In contrast to canonical PRC1, Pcgf6 acts as a positive regulator of transcription and binds predominantly to promoters bearing active chromatin marks. Pcgf6 is expressed at high levels in ESCs, and knockdown reduces the expression of the core ESC regulators Oct4, Sox2, and Nanog. Conversely, Pcgf6 overexpression prevents downregulation of these factors and impairs differentiation. In addition, Pcgf6 enhanced reprogramming in both mouse and human somatic cells. The genomic binding profile of Pcgf6 is highly similar to that of trithorax group proteins, but not of PRC1 or PRC2 complexes, suggesting that Pcgf6 functions atypically in ESCs. Our data reveal novel roles for Pcgf6 in directly regulating Oct4, Nanog, Sox2, and Lin28 expression to maintain ESC identity. PMID:27247273

  7. Abelson kinase acts as a robust, multifunctional scaffold in regulating embryonic morphogenesis

    PubMed Central

    Rogers, Edward M.; Spracklen, Andrew J.; Bilancia, Colleen G.; Sumigray, Kaelyn D.; Allred, S. Colby; Nowotarski, Stephanie H.; Schaefer, Kristina N.; Ritchie, Benjamin J.; Peifer, Mark

    2016-01-01

    Abelson family kinases (Abls) are key regulators of cell behavior and the cytoskeleton during development and in leukemia. Abl’s SH3, SH2, and tyrosine kinase domains are joined via a linker to an F-actin–binding domain (FABD). Research on Abl’s roles in cell culture led to several hypotheses for its mechanism of action: 1) Abl phosphorylates other proteins, modulating their activity, 2) Abl directly regulates the cytoskeleton via its cytoskeletal interaction domains, and/or 3) Abl is a scaffold for a signaling complex. The importance of these roles during normal development remains untested. We tested these mechanistic hypotheses during Drosophila morphogenesis using a series of mutants to examine Abl’s many cell biological roles. Strikingly, Abl lacking the FABD fully rescued morphogenesis, cell shape change, actin regulation, and viability, whereas kinase-dead Abl, although reduced in function, retained substantial rescuing ability in some but not all Abl functions. We also tested the function of four conserved motifs in the linker region, revealing a key role for a conserved PXXP motif known to bind Crk and Abi. We propose that Abl acts as a robust multidomain scaffold with different protein motifs and activities contributing differentially to diverse cellular behaviors. PMID:27385341

  8. RCRA COVER SYSTEMS FOR WASTE MANAGEMENT FACILITIES

    EPA Science Inventory

    The closure of waste management facilities, whether Subtitle C, Subtitle D or CERCLA, requires consideration of site-specific information, the Federal regulations and applicability of state regulations and the liquids management strategy. This paper will present the current EPA ...

  9. 12 CFR 335.901 - Delegation of authority to act on matters with respect to disclosure laws and regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... respect to disclosure laws and regulations. 335.901 Section 335.901 Banks and Banking FEDERAL DEPOSIT... § 335.901 Delegation of authority to act on matters with respect to disclosure laws and regulations. (a... Supervision and Consumer Protection (DSC), and where confirmed in writing by the director, to a...

  10. Impact of new regulations on training programs

    SciTech Connect

    Copenhaver, E.D.

    1987-09-01

    Safety and health training is creating a complex and overlapping training environment for all DOE contractors. Requirements stem from a variety of Federal and state regulations such as those from the Resource Conservation and Recovery Act (RCRA), the Superfund Amendments Reauthorization Act (SARA, whose training requirements are carried out by OSHA), Hazard Communication Act, and several substance-specific laws. The training requirements of these regulations and the trends toward overlapping the requirements of several laws are reviewed. Environment, safety and health training is offered by the technical staff members in the relevant disciplines and by our multi-discipline training group at ORNL. We are increasing our coordination of all such efforts to develop a more orderly overall program. We identified a team to work toward coordination of required technical training in environment, safety, and health by listing key opportunities for technical training modules and cross-qualification. The strategy for developing the training matrix is outlined. 13 figs.

  11. The marriage of RCRA and CERCLA at the Rocky Flats Environmental Technology Site

    SciTech Connect

    Shelton, D.C.; Brooks, L.M.

    1998-11-01

    A key goal of the Rocky Flats Cleanup Agreement (RFCA) signed in July of 1996 was to provide a seamless marriage of the Resource Conservation and Recovery Act (RCRA) (and other media specific programs) and the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) and the implementing agencies of each. This paper examines the two years since the signing of RFCA and identifies the successes, failures, and stresses of the marriage. RFCA has provided an excellent vehicle for regulatory and substantive progress at the Department of Energy`s Rocky Flats facility. The key for a fully successful marriage is to build on the accomplishments to date and to continually improve the internal and external systems and relationships. To date, the parties can be proud of both the substantial accomplishment of substantive environmental work and the regulatory systems that have enabled the work.

  12. Proposed modifications to the RCRA post-closure permit for the Upper East Fork Poplar Creek Hydrogeologic Regime at the U.S. Department of Energy Y-12 Plant, Oak Ridge, Tennessee

    SciTech Connect

    1997-05-01

    This report presents proposed modifications to the Resource Conservation and Recovery Act (RCRA) Post-Closure Permit (PCP) for the Upper East Fork Poplar Creek Hydrogeologic Regime (permit number TNHW-088, EPA ID No. TN3 89 009 0001). The modifications are proposed to: (1) revise the current text for two of the Permit Conditions included in Permit Section II - General Facility Conditions, and (2) update the PCP with revised versions of the Y-12 Plant Groundwater Protection Program (GWPP) technical field procedures included in several of the Permit Attachments. The updated field procedures and editorial revisions are Class 1 permit modifications, as specified in Title 40, Code of Federal Regulations (CFR) {section}270.42; Appendix I - Classification of Permit Modifications. These modifications are summarized below.

  13. atonal regulates neurite arborization but does not act as a proneural gene in the Drosophila brain

    NASA Technical Reports Server (NTRS)

    Hassan, B. A.; Bermingham, N. A.; He, Y.; Sun, Y.; Jan, Y. N.; Zoghbi, H. Y.; Bellen, H. J.

    2000-01-01

    Drosophila atonal (ato) is the proneural gene of the chordotonal organs (CHOs) in the peripheral nervous system (PNS) and the larval and adult photoreceptor organs. Here, we show that ato is expressed at multiple stages during the development of a lineage of central brain neurons that innervate the optic lobes and are required for eclosion. A novel fate mapping approach shows that ato is expressed in the embryonic precursors of these neurons and that its expression is reactivated in third instar larvae (L3). In contrast to its function in the PNS, ato does not act as a proneural gene in the embryonic brain. Instead, ato performs a novel function, regulating arborization during larval and pupal development by interacting with Notch.

  14. Enhancer of zeste acts as a major developmental regulator of Ciona intestinalis embryogenesis

    PubMed Central

    Le Goff, Emilie; Martinand-Mari, Camille; Martin, Marianne; Feuillard, Jérôme; Boublik, Yvan; Godefroy, Nelly; Mangeat, Paul; Baghdiguian, Stephen; Cavalli, Giacomo

    2015-01-01

    ABSTRACT The paradigm of developmental regulation by Polycomb group (PcG) proteins posits that they maintain silencing outside the spatial expression domains of their target genes, particularly of Hox genes, starting from mid embryogenesis. The Enhancer of zeste [E(z)] PcG protein is the catalytic subunit of the PRC2 complex, which silences its targets via deposition of the H3K27me3 mark. Here, we studied the ascidian Ciona intestinalis counterpart of E(z). Ci-E(z) is detected by immunohistochemistry as soon as the 2- and 4-cell stages as a cytoplasmic form and becomes exclusively nuclear thereafter, whereas the H3K27me3 mark is detected starting from the gastrula stage and later. Morpholino invalidation of Ci-E(z) leads to the total disappearance of both Ci-E(z) protein and its H3K27me3 mark. Ci-E(z) morphants display a severe phenotype. Strikingly, the earliest defects occur at the 4-cell stage with the dysregulation of cell positioning and mitotic impairment. At later stages, Ci-E(z)-deficient embryos are affected by terminal differentiation defects of neural, epidermal and muscle tissues, by the failure to form a notochord and by the absence of caudal nerve. These major phenotypic defects are specifically rescued by injection of a morpholino-resistant Ci-E(z) mRNA, which restores expression of Ci-E(z) protein and re-deposition of the H3K27me3 mark. As observed by qPCR analyses, Ci-E(z) invalidation leads to the early derepression of tissue-specific developmental genes, whereas late-acting developmental genes are generally down-regulated. Altogether, our results suggest that Ci-E(z) plays a major role during embryonic development in Ciona intestinalis by silencing early-acting developmental genes in a Hox-independent manner. PMID:26276097

  15. STABILIZATION/SOLIDIFICATION OF CERCLA AND RCRA WASTES

    EPA Science Inventory

    This Handbook provides U.S. EPA regional staff responsible for reviewing CERCLA remedial action plans and RCRA permit applications with a tool for interpreting information on stabilization/solidification treatment. As a practical day-to-day reference guide, it will also provide t...

  16. RCRA permit modifications and the functional equivalency demonstration: A case study

    SciTech Connect

    Kinker, J.; Lyon, W.; Carnes, R.; Loehr, C.; Elsberry, K.; Garcia, P.

    1996-05-01

    Hazardous waste operating permits issued under the Resource Conservation and Recovery Act (RCRA) often impose requirements, typically by reference to the original permit application, that specific components and equipment be used. Consequently, changing these items, even for the purpose of routine maintenance, may first require that the owner/operator request a potentially time-consuming and costly permit modification. However, the owner/operator may demonstrate that a modification is not required because the planned changes are functionally equivalent, as defined by RCRA, to the original specifications embodied by the permit. The Controlled-Air Incinerator at Los Alamos National Laboratory is scheduled for maintenance and improvements that involve replacement of components. The incinerator`s carbon adsorption unit/high efficiency particulate air filtration system, in particular, was redesigned to improve reliability and minimize maintenance. A study was performed to determine whether the redesigned unit would qualify as functionally equivalent to the original component. in performing this study, the following steps were taken: (a) the key performance factors were identified; (b) performance data describing the existing unit were obtained; (c) performance of both the existing and redesigned units was simulated; and (d) the performance data were compared to ascertain whether the components could qualify as functionally equivalent.

  17. Transportable Vitrification System RCRA Closure Practical Waste Disposition Saves Time And Money

    SciTech Connect

    Brill, Angie; Boles, Roger; Byars, Woody

    2003-02-26

    The Transportable Vitrification System (TVS) was a large-scale vitrification system for the treatment of mixed wastes. The wastes contained both hazardous and radioactive materials in the form of sludge, soil, and ash. The TVS was developed to be moved to various United States Department of Energy (DOE) facilities to vitrify mixed waste as needed. The TVS consists of four primary modules: (1) Waste and Additive Materials Processing Module; (2) Melter Module; (3) Emissions Control Module; and (4) Control and Services Module. The TVS was demonstrated at the East Tennessee Technology Park (ETTP) during September and October of 1997. During this period, approximately 16,000 pounds of actual mixed waste was processed, producing over 17,000 pounds of glass. After the demonstration was complete it was determined that it was more expensive to use the TVS unit to treat and dispose of mixed waste than to direct bury this waste in Utah permitted facility. Thus, DOE had to perform a Resource Conservation and Recovery Act (RCRA) closure of the facility and find a reuse for as much of the equipment as possible. This paper will focus on the following items associated with this successful RCRA closure project: TVS site closure design and implementation; characterization activities focused on waste disposition; pollution prevention through reuse; waste minimization efforts to reduce mixed waste to be disposed; and lessons learned that would be integrated in future projects of this magnitude.

  18. Genome-wide prediction of cis-acting RNA elements regulating tissue-specific pre-mRNA alternative splicing

    PubMed Central

    Wang, Xin; Wang, Kejun; Radovich, Milan; Wang, Yue; Wang, Guohua; Feng, Weixing; Sanford, Jeremy R; Liu, Yunlong

    2009-01-01

    Background Human genes undergo various patterns of pre-mRNA splicing across different tissues. Such variation is primarily regulated by trans-acting factors that bind on exonic and intronic cis-acting RNA elements (CAEs). Here we report a computational method to mechanistically identify cis-acting RNA elements that contribute to the tissue-specific alternative splicing pattern. This method is an extension of our previous model, SplicingModeler, which predicts the significant CAEs that contribute to the splicing differences between two tissues. In this study, we introduce tissue-specific functional levels estimation step, which allows evaluating regulatory functions of predicted CAEs that are involved in more than two tissues. Results Using a publicly available Affymetrix Genechip® Human Exon Array dataset, our method identifies 652 cis-acting RNA elements (CAEs) across 11 human tissues. About one third of predicted CAEs can be mapped to the known RBP (RNA binding protein) binding sites or match with other predicted exonic splicing regulator databases. Interestingly, the vast majority of predicted CAEs are in intronic regulatory regions. A noticeable exception is that many exonic elements are found to regulate the alternative splicing between cerebellum and testes. Most identified elements are found to contribute to the alternative splicing between two tissues, while some are important in multiple tissues. This suggests that genome-wide alternative splicing patterns are regulated by a combination of tissue-specific cis-acting elements and "general elements" whose functional activities are important but differ across multiple tissues. Conclusion In this study, we present a model-based computational approach to identify potential cis-acting RNA elements by considering the exon splicing variation as the combinatorial effects of multiple cis-acting regulators. This methodology provides a novel evaluation on the functional levels of cis-acting RNA elements by estimating

  19. Enforcement actions under the Resource Conservation and Recovery Act. Final report

    SciTech Connect

    Brown, D.M.; Baxter, R.J.

    1994-09-01

    The Army continues to receive enforcement actions (EAS) that detract from its image as a conscientious adherent to environmental laws. In some cases, receipt of violations may indicate the persistent presence of systemic problems. In the past 2 years, the Army has been investigating its EAs to determine whether some problems are more prevalent than others and what can be done to resolve them. This report addresses EAs issued to the Army pursuant to the Resource Conservation and Recovery Act (RCRA) and similar state laws and their implementing regulations. RCRA is similar to other regulatory programs reviewed by the Logistics Management Institute, in that the root causes were in procedural and oversight failures. Thus, action taken to address the systemic problems in any of the environmental program areas should relieve compliance problems in all areas. The systemic problems occur in four general areas: maintaining knowledgeable staff; spreading awareness of requirements to operators and supervisors who are not part of the environmental staff; improving oversight of environmentally sensitive operations conducted by both government and contractor personnel; and, once people have the appropriate knowledge, holding them responsible for applying it. We recommend that the Army hold individuals having responsibility for the operation and oversight of environmentally sensitive facilities accountable for proper performance, devise means to make RCRA training more effective, and require certifications and continuing professional development of environmental professionals.

  20. Flavonoids act as negative regulators of auxin transport in vivo in arabidopsis

    NASA Technical Reports Server (NTRS)

    Brown, D. E.; Rashotte, A. M.; Murphy, A. S.; Normanly, J.; Tague, B. W.; Peer, W. A.; Taiz, L.; Muday, G. K.

    2001-01-01

    Polar transport of the plant hormone auxin controls many aspects of plant growth and development. A number of synthetic compounds have been shown to block the process of auxin transport by inhibition of the auxin efflux carrier complex. These synthetic auxin transport inhibitors may act by mimicking endogenous molecules. Flavonoids, a class of secondary plant metabolic compounds, have been suggested to be auxin transport inhibitors based on their in vitro activity. The hypothesis that flavonoids regulate auxin transport in vivo was tested in Arabidopsis by comparing wild-type (WT) and transparent testa (tt4) plants with a mutation in the gene encoding the first enzyme in flavonoid biosynthesis, chalcone synthase. In a comparison between tt4 and WT plants, phenotypic differences were observed, including three times as many secondary inflorescence stems, reduced plant height, decreased stem diameter, and increased secondary root development. Growth of WT Arabidopsis plants on naringenin, a biosynthetic precursor to those flavonoids with auxin transport inhibitor activity in vitro, leads to a reduction in root growth and gravitropism, similar to the effects of synthetic auxin transport inhibitors. Analyses of auxin transport in the inflorescence and hypocotyl of independent tt4 alleles indicate that auxin transport is elevated in plants with a tt4 mutation. In hypocotyls of tt4, this elevated transport is reversed when flavonoids are synthesized by growth of plants on the flavonoid precursor, naringenin. These results are consistent with a role for flavonoids as endogenous regulators of auxin transport.

  1. Progesterone acts via progesterone receptors A and B to regulate breast cancer resistance protein expression.

    PubMed

    Vore, Mary; Leggas, Markos

    2008-03-01

    The breast cancer resistance protein (BCRP; ABCG2) is an ATP-dependent efflux multidrug transporter that belongs to the G family of half-transporters that consist of six transmembrane-spanning domains and must homodimerize to form the active membrane transporter. It is expressed in the apical plasma membrane domain of the small intestine, endothelium, and liver, where it has been shown to play an important role in limiting drug absorption and distribution and in enhancing drug clearance, respectively. BCRP is also expressed in the apical membrane of mammary alveolar epithelia, where it mediates efflux of substrates into milk, and in the placental syncytiotro-phoblasts, where it reduces fetal exposure to these substrates. BCRP substrates include numerous drugs (topotecan, nitrofurantoin, cimetidine) as well as food carcinogens (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and the vitamins riboflavin and folic acid. BCRP expression is regulated by a number of nuclear transcription factors, including the peroxisome proliferator-activated receptor-gamma and Hif-1. This issue of Molecular Pharmacology includes a study (p. 845) now conclusively demonstrating that progesterone acts via the progesterone A and B receptors to regulate BCRP expression in a placental cell line.

  2. PKR is activated by cellular dsRNAs during mitosis and acts as a mitotic regulator

    PubMed Central

    Kim, Yoosik; Lee, Jung Hyun; Park, Jong-Eun; Cho, Jun; Yi, Hyerim; Kim, V. Narry

    2014-01-01

    dsRNA-dependent protein kinase R (PKR) is a ubiquitously expressed enzyme well known for its roles in immune response. Upon binding to viral dsRNA, PKR undergoes autophosphorylation, and the phosphorylated PKR (pPKR) regulates translation and multiple signaling pathways in infected cells. Here, we found that PKR is activated in uninfected cells, specifically during mitosis, by binding to dsRNAs formed by inverted Alu repeats (IRAlus). While PKR and IRAlu-containing RNAs are segregated in the cytosol and nucleus of interphase cells, respectively, they interact during mitosis when nuclear structure is disrupted. Once phosphorylated, PKR suppresses global translation by phosphorylating the α subunit of eukaryotic initiation factor 2 (eIF2α). In addition, pPKR acts as an upstream kinase for c-Jun N-terminal kinase and regulates the levels of multiple mitotic factors such as CYCLINS A and B and POLO-LIKE KINASE 1 and phosphorylation of HISTONE H3. Disruption of PKR activation via RNAi or expression of a transdominant-negative mutant leads to misregulation of the mitotic factors, delay in mitotic progression, and defects in cytokinesis. Our study unveils a novel function of PKR and endogenous dsRNAs as signaling molecules during the mitosis of uninfected cells. PMID:24939934

  3. PKR is activated by cellular dsRNAs during mitosis and acts as a mitotic regulator.

    PubMed

    Kim, Yoosik; Lee, Jung Hyun; Park, Jong-Eun; Cho, Jun; Yi, Hyerim; Kim, V Narry

    2014-06-15

    dsRNA-dependent protein kinase R (PKR) is a ubiquitously expressed enzyme well known for its roles in immune response. Upon binding to viral dsRNA, PKR undergoes autophosphorylation, and the phosphorylated PKR (pPKR) regulates translation and multiple signaling pathways in infected cells. Here, we found that PKR is activated in uninfected cells, specifically during mitosis, by binding to dsRNAs formed by inverted Alu repeats (IRAlus). While PKR and IRAlu-containing RNAs are segregated in the cytosol and nucleus of interphase cells, respectively, they interact during mitosis when nuclear structure is disrupted. Once phosphorylated, PKR suppresses global translation by phosphorylating the α subunit of eukaryotic initiation factor 2 (eIF2α). In addition, pPKR acts as an upstream kinase for c-Jun N-terminal kinase and regulates the levels of multiple mitotic factors such as cyclins A and B and Polo-like kinase 1 and phosphorylation of histone H3. Disruption of PKR activation via RNAi or expression of a transdominant-negative mutant leads to misregulation of the mitotic factors, delay in mitotic progression, and defects in cytokinesis. Our study unveils a novel function of PKR and endogenous dsRNAs as signaling molecules during the mitosis of uninfected cells.

  4. Neuropeptide Y acts in the paraventricular nucleus to suppress sympathetic nerve activity and its baroreflex regulation.

    PubMed

    Cassaglia, Priscila A; Shi, Zhigang; Li, Baoxin; Reis, Wagner L; Clute-Reinig, Nicholas M; Stern, Javier E; Brooks, Virginia L

    2014-04-01

    Neuropeptide Y (NPY), a brain neuromodulator that has been strongly implicated in the regulation of energy balance, also acts centrally to inhibit sympathetic nerve activity (SNA); however, the site and mechanism of action are unknown. In chloralose-anaesthetized female rats, nanoinjection of NPY into the paraventricular nucleus of the hypothalamus (PVN) dose-dependently suppressed lumbar SNA (LSNA) and its baroreflex regulation, and these effects were blocked by prior inhibition of NPY Y1 or Y5 receptors. Moreover, PVN injection of Y1 and Y5 receptor antagonists in otherwise untreated rats increased basal and baroreflex control of LSNA, indicating that endogenous NPY tonically inhibits PVN presympathetic neurons. The sympathoexcitation following blockade of PVN NPY inhibition was eliminated by prior PVN nanoinjection of the melanocortin 3/4 receptor inhibitor SHU9119. Moreover, presympathetic neurons, identified immunohistochemically using cholera toxin b neuronal tract tracing from the rostral ventrolateral medulla (RVLM), express NPY Y1 receptor immunoreactivity, and patch-clamp recordings revealed that both NPY and α-melanocyte-stimulating hormone (α-MSH) inhibit and stimulate, respectively, PVN-RVLM neurons. Collectively, these data suggest that PVN NPY inputs converge with α-MSH to influence presympathetic neurons. Together these results identify endogenous NPY as a novel and potent inhibitory neuromodulator within the PVN that may contribute to changes in SNA that occur in states associated with altered energy balance, such as obesity and pregnancy. PMID:24535439

  5. Flavonoids Act as Negative Regulators of Auxin Transport in Vivo in Arabidopsis1

    PubMed Central

    Brown, Dana E.; Rashotte, Aaron M.; Murphy, Angus S.; Normanly, Jennifer; Tague, Brian W.; Peer, Wendy A.; Taiz, Lincoln; Muday, Gloria K.

    2001-01-01

    Polar transport of the plant hormone auxin controls many aspects of plant growth and development. A number of synthetic compounds have been shown to block the process of auxin transport by inhibition of the auxin efflux carrier complex. These synthetic auxin transport inhibitors may act by mimicking endogenous molecules. Flavonoids, a class of secondary plant metabolic compounds, have been suggested to be auxin transport inhibitors based on their in vitro activity. The hypothesis that flavonoids regulate auxin transport in vivo was tested in Arabidopsis by comparing wild-type (WT) and transparent testa (tt4) plants with a mutation in the gene encoding the first enzyme in flavonoid biosynthesis, chalcone synthase. In a comparison between tt4 and WT plants, phenotypic differences were observed, including three times as many secondary inflorescence stems, reduced plant height, decreased stem diameter, and increased secondary root development. Growth of WT Arabidopsis plants on naringenin, a biosynthetic precursor to those flavonoids with auxin transport inhibitor activity in vitro, leads to a reduction in root growth and gravitropism, similar to the effects of synthetic auxin transport inhibitors. Analyses of auxin transport in the inflorescence and hypocotyl of independent tt4 alleles indicate that auxin transport is elevated in plants with a tt4 mutation. In hypocotyls of tt4, this elevated transport is reversed when flavonoids are synthesized by growth of plants on the flavonoid precursor, naringenin. These results are consistent with a role for flavonoids as endogenous regulators of auxin transport. PMID:11402184

  6. Decree No. 0784 of 18 April 1989 regulating, in part, Act 21 of 1982 and Act 71 of 1988.

    PubMed

    1989-01-01

    This Colombian Decree regulates certain aspects of the system of family allowances. Among other things, it provides that allowances can be granted in terms of food, clothing, school scholarships, textbooks, drugs, and other substitutes for money. Further provisions of the Decree deal with the definition of persons affiliated to the regime, booklets certifying affiliation, family service subsidies, and financing. PMID:12344547

  7. Decree No. 0784 of 18 April 1989 regulating, in part, Act 21 of 1982 and Act 71 of 1988.

    PubMed

    1989-01-01

    This Colombian Decree regulates certain aspects of the system of family allowances. Among other things, it provides that allowances can be granted in terms of food, clothing, school scholarships, textbooks, drugs, and other substitutes for money. Further provisions of the Decree deal with the definition of persons affiliated to the regime, booklets certifying affiliation, family service subsidies, and financing.

  8. Allowance trading under the Clean Air Act: Who should regulate, and when?

    SciTech Connect

    Lock, R.

    1993-07-01

    The goal of this paper is to explore how compliance with the Clean Air Act Amendments of 1990 (CAAA), especially Title IV and emission trading under it, will affect the current relationship between state and federal regulation. It is difficult, with the limited experience we have had under Title IV, to be definitive about or to be a very strong advocate of too many policy positions. What may be most helpful at this point is to identify where the difficult issues in state/federal relations might arise; and then to explore ways in which tensions might be either avoided or resolved. One anticipated conclusion is that a traditional regulatory mindset could be very destructive if applied to this new area of oversight without due sensitivity to what Congress is trying to achieve in Title IV. That concern pervaded the early legislative debates; and it persists today. Title IV presents some unique challenges to state regulators and will require some creative solutions and fresh thinking if the goals of Congress are to be realized and the full benefits that allowance trading can offer are to be reaped by electricity consumers. In the ultimate analysis, Title IV amounts to a massive internalization of the external costs imposed on society by acid rain deposition. (This places in serious question the notion of additional externality {open_quotes}adders{close_quotes} for sulfur dioxide (SO{sub 2}) and nitrous oxide (NO{sub x}) at the state level for utility supply planning purposes.) The whole point of Title IV is to give those directly charged with compliance, namely power producers, the maximum flexibility to pursue least-cost compliance solutions. Perhaps the biggest single factor in how well they do this will be how state regulators respond to their compliance and allowance trading initiatives.

  9. HIPAA Newborns' and Mothers' Health Protection Act--IRS. Notice of proposed rulemaking by cross-reference to temporary regulations.

    PubMed

    1998-10-27

    Elsewhere in this issue of the Federal Register, the IRS is issuing temporary regulations relating to minimum hospital length-of-stay requirements imposed on group health plans with respect to mothers and newborns. The hospital length-of-stay requirements were added to the Internal Revenue Code by section 1531 of the Taxpayer Relief Act of 1997. The IRS is issuing the temporary regulations at the same time that the Pension and Welfare Benefits Administration of the U.S. Department of Labor and the Health Care Financing Administration of the U.S. Department of Health and Human Services are issuing substantially similar interim final regulations relating to hospital length-of-stay requirements added by the Newborns' and Mothers' Health Protection Act of 1996 to the Employee Retirement Income Security Act of 1974 and the Public Health Service Act. The temporary regulations provide guidance to employers and group health plans relating to the new hospital length-of-stay requirements. The text of those temporary regulations also serves as the text of these proposed regulations.

  10. RCRA designation of discarded americium/beryllium sealed sources

    SciTech Connect

    Kirner, N.P.

    1994-09-01

    Many sealed sources containing americium and beryllium are used throughout construction, industry, and research, and will eventually require disposal. For planning purposes it is necessary to determine whether these sources, when disposed, constitute a mixed waste, i.e., a waste containing hazardous constituents regulated under the Resource Conservation and Recovery Act and radioactive constituents regulated under the Atomic Energy Act. Waste designation criteria contained in 40 CFR 261 are evaluated in detail in this report. It is determined that discarded americium/beryllium sealed sources do not contain any wastes listed in Subpart D of 40 CFR 261, nor do the discarded sources exhibit any hazardous characteristics. Therefore, it is concluded that discarded americium/beryllium sealed sources are not a mixed waste under regulations established by the US Environmental Protection Agency. Hazardous waste regulatory programs delegated to States, however, may have regulations that differ from those of the Federal government.

  11. Setting a precedent: California`s overhaul of hazwaste regulations could cause ripple effect across the U.S.

    SciTech Connect

    Gilbert-Miller, S.

    1996-01-01

    California advanced a reputation of being the vanguard of environmental protection by adopting hazardous waste management standards in 1972, four years before passage of the Resource Conservation and Recovery Act. Even after RCRA became law, California continued to develop a system of regulation which was considerably more stringent than the federal standards. State regulations gave rise to a category of hazardous waste commonly referred to as California-only because it was not considered hazardous under RCRA provisions. Now, more than 20 years later, California is embarking on a new course of environmental policymaking that potentially could do away with the very provisions that originally contributed to the state`s progressive reputation. The method by which this feat of deregulation would be achieved is itself an innovation in public policymaking which, in light of national political sentiment for environmental deregulation, could make the Californian process a model for the rest of the nation.

  12. RCRA Facility Investigation report for Waste Area Grouping 6 at Oak Ridge National Laboratory, Oak Ridge, Tennessee. Volume 1. Sections 1 through 3

    SciTech Connect

    1991-09-01

    WAG 6 comprises a shallow land burial facility used for disposal of low-level radioactive wastes (LLW) and, until recently, chemical wastes. As such, the site is subject to regulation under RCRA and the Comprehensive Environmental Response Compensation and Liability Act (CERCLA). To comply with these regulations, DOE, in conjunction with the Environmental Protection Agency (EPA) and the Tennessee Department of Environment and Conservation (TDEC), developed a strategy for closure and remediation of WAG 6 by 1997. A key component of this strategy was to complete an RFI by September 1991. The primary objectives of the RFI were to evaluate the site's potential human health and environmental impacts and to develop a preliminary list of alternatives to mitigate these impacts. The WAG 6 one of three solid waste management units evaluated Oak Ridge National Laboratory (ORNL) existing waste disposal records and sampling data and performed the additional sampling and analysis necessary to: describe the nature and extent of contamination; characterize key contaminant transport pathways; and assess potential risks to human health and the environment by developing and evaluating hypothetical receptor scenarios. Estimated excess lifetime cancer risks as a result for exposure to radionuclides and chemicals were quantified for each hypothetical human receptor. For environmental receptors, potential impacts were qualitatively assessed. Taking into account regulatory requirements and base line risk assessment results, preliminary site closure and remediation objectives were identified, and a preliminary list of alternatives for site closure and remediation was developed.

  13. RCRA Facility Investigation report for Waste Area Grouping 6 at Oak Ridge National Laboratory, Oak Ridge, Tennessee. Volume 1, Sections 1 through 3: Environmental Restoration Program

    SciTech Connect

    Not Available

    1991-09-01

    WAG 6 comprises a shallow land burial facility used for disposal of low-level radioactive wastes (LLW) and, until recently, chemical wastes. As such, the site is subject to regulation under RCRA and the Comprehensive Environmental Response Compensation and Liability Act (CERCLA). To comply with these regulations, DOE, in conjunction with the Environmental Protection Agency (EPA) and the Tennessee Department of Environment and Conservation (TDEC), developed a strategy for closure and remediation of WAG 6 by 1997. A key component of this strategy was to complete an RFI by September 1991. The primary objectives of the RFI were to evaluate the site`s potential human health and environmental impacts and to develop a preliminary list of alternatives to mitigate these impacts. The WAG 6 one of three solid waste management units evaluated Oak Ridge National Laboratory (ORNL) existing waste disposal records and sampling data and performed the additional sampling and analysis necessary to: describe the nature and extent of contamination; characterize key contaminant transport pathways; and assess potential risks to human health and the environment by developing and evaluating hypothetical receptor scenarios. Estimated excess lifetime cancer risks as a result for exposure to radionuclides and chemicals were quantified for each hypothetical human receptor. For environmental receptors, potential impacts were qualitatively assessed. Taking into account regulatory requirements and base line risk assessment results, preliminary site closure and remediation objectives were identified, and a preliminary list of alternatives for site closure and remediation was developed.

  14. The differential regulation of human ACT1 isoforms by Hsp90 in IL-17 signaling1

    PubMed Central

    Wu, Ling; Wang, Chenhui; Boisson, Bertrand; Misra, Saurav; Rayman, Patricia; Finke, James H.; Puel, Anne; Casanova, Jean-Laurent; Li, Xiaoxia

    2014-01-01

    IL-17 is a pro-inflammatory cytokine implicated in the pathogenesis of autoimmune diseases including psoriasis. ACT1 is an essential adaptor molecule in the IL-17 signaling pathway. A missense single nucleotide polymorphism (rs33980500; SNP-D10N) that resulted in the substitution of an asparagine for an aspartic acid at position 10 of ACT1 (ACT1-D10N) is associated with psoriasis susceptibility. Due to alternative splicing in humans, SNP-D10N encodes two mutated ACT1 proteins, ACT1-D10N and ACT1-D19N. Though both ACT1 isoforms are Hsp90 ‘client’ proteins, the nine additional amino acids in ACT1-D19N provide an additional Hsp90 binding site that is absent in ACT1-D10N. Therefore, while ACT1-D10N is a dead protein that is unable to transduce IL-17 signals for gene expression, ACT1-D19N is fully responsive to IL-17. Intriguingly, the two ACT1 isoforms are differentially expressed in ACT1D10N/D10N fibroblasts and T cells. Fibroblasts express both isoforms equally, enabling ACT1-D19N to compensate for the loss of ACT1-D10N function. ACT1D10N/D10N T cells, however, express predominantly ACT1-D10N. Lacking this compensatory mechanism, ACT1D10N/D10N T cells behave like ACT1-deficient T cells, exhibiting a dysregulated and hyperactive Th17 phenotype with overproduction of IL-22 and IL-17. The hyperactive Th17 response combined with fully responsive fibroblasts likely synergized to contribute to psoriasis susceptibility in SNP-D10N patients. PMID:25024377

  15. The differential regulation of human ACT1 isoforms by Hsp90 in IL-17 signaling.

    PubMed

    Wu, Ling; Wang, Chenhui; Boisson, Bertrand; Misra, Saurav; Rayman, Patricia; Finke, James H; Puel, Anne; Casanova, Jean-Laurent; Li, Xiaoxia

    2014-08-15

    IL-17 is a proinflammatory cytokine implicated in the pathogenesis of autoimmune diseases including psoriasis. ACT1 is an essential adaptor molecule in the IL-17 signaling pathway. A missense single nucleotide polymorphism (rs33980500; SNP-D10N) that resulted in the substitution of an asparagine for an aspartic acid at position 10 of ACT1 (ACT1-D10N) is associated with psoriasis susceptibility. Due to alternative splicing in humans, SNP-D10N encodes two mutated ACT1 proteins, ACT1-D10N and ACT1-D19N. Although both ACT1 isoforms are Hsp90 client proteins, the nine additional amino acids in ACT1-D19N provide an additional Hsp90 binding site that is absent in ACT1-D10N. Therefore, whereas ACT1-D10N is a dead protein that is unable to transduce IL-17 signals for gene expression, ACT1-D19N is fully responsive to IL-17. Intriguingly, the two ACT1 isoforms are differentially expressed in ACT1(D10N/D10N) fibroblasts and T cells. Fibroblasts express both isoforms equally, enabling ACT1-D19N to compensate for the loss of ACT1-D10N function. ACT1(D10N/D10N) T cells, however, express predominantly ACT1-D10N. Lacking this compensatory mechanism, ACT1(D10N/D10N) T cells behave like ACT1-deficient T cells, exhibiting a dysregulated and hyperactive Th17 phenotype with overproduction of IL-22 and IL-17. The hyperactive Th17 response combined with fully responsive fibroblasts likely synergized to contribute to psoriasis susceptibility in SNP-D10N patients. PMID:25024377

  16. Some impacts of the 1990 Clean Air Act and state clean-air regulations on the fertilizer industry

    SciTech Connect

    Breed, C.E.; Kerns, O.S.

    1992-12-31

    The Clean Air Act amendments of 1990 will intensify national efforts to reduce air pollution. They will have major impacts on governmental agencies and on industrial and commercial facilities throughout the country. As with other industries, it is essential for fertilizer dealers and producers to understand how these changes to the Clean Air Act can significantly change the way they do business. This paper is proffered as an overview of ways in which the 1990 amendments to the Clean Air Act may impact the fertilizer industry. The nonattainment, toxics, and permit provisions of the amended act will be three areas of particular concern to the fertilizer industry. Implementation of the new regulatory requirements of this legislation promises to be a long and onerous process for all concerned. However, it appears that state and local regulations may have a much more profound impact on the fertilizer industry than the new Clean Air Act.

  17. Some impacts of the 1990 Clean Air Act and state clean-air regulations on the fertilizer industry

    SciTech Connect

    Breed, C.E.; Kerns, O.S.

    1992-12-01

    The Clean Air Act amendments of 1990 will intensify national efforts to reduce air pollution. They will have major impacts an governmental agencies and on industrial and commercial facilities throughout the country. As with other industries, it is essential for fertilizer dealers and producers to understand how these changes to the Clean Air Act can significantly change the way they do business. This paper is proffered as an overview of ways in which the 1990 amendments to the Clean Air Act may impact the fertilizer industry. The nonattainment, toxics, and permit provisions of the amended act will be three areas of particular concern to the fertilizer industry. Implementation of the new regulatory requirements of this legislation promises to be a long and onerous process for all concerned. However, it appears that state and local regulations may have a much more profound impact on the fertilizer industry than the new Clean Air Act.

  18. Defending Superfund and RCRA imminent hazard cases

    SciTech Connect

    Miller, J.G.

    1983-01-01

    Legal defenses by the government under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (Superfund) and the Resource Conservation and Recovery Act include common defenses in which there is (1) no imminent or substantial endangerment, (2) inappropriate remedy, (3) action not in accord with the National Contingency Plan that governs Environmental Protection Agency (EPA) remedial actions, (4) not credible or sufficient evidence, (5) not credible scientific conclusion, or (6) government action precluding the relief. Defenses to Superfund reimbursement claims include cases (1) when defendant is not among the class of liable partners, (2) of joint and several liability and the right of contribution, (3) involving releases by an act of God, war, or third party. Defenses to abatement actions include cases in which (1) there is no irreparable harm and adequate remedy at law is available and (2) emergency provisions are not retrospective. Also relevant to EPA enforcement efforts are political pressures and the government's intentions. The author discusses basic defense strategies and implementation tactics. 67 references.

  19. Positive Selection within a Diatom Species Acts on Putative Protein Interactions and Transcriptional Regulation

    PubMed Central

    Koester, Julie A.; Swanson, Willie J.; Armbrust, E. Virginia

    2013-01-01

    Diatoms are the most species-rich group of microalgae, and their contribution to marine primary production is important on a global scale. Diatoms can form dense blooms through rapid asexual reproduction; mutations acquired and propagated during blooms likely provide the genetic, and thus phenotypic, variability upon which natural selection may act. Positive selection was tested using genome and transcriptome-wide pair-wise comparisons of homologs in three genera of diatoms (Pseudo-nitzschia, Ditylum, and Thalassiosira) that represent decreasing phylogenetic distances. The signal of positive selection was greatest between two strains of Thalassiosira pseudonana. Further testing among seven strains of T. pseudonana yielded 809 candidate genes of positive selection, which are 7% of the protein-coding genes. Orphan genes and genes encoding protein-binding domains and transcriptional regulators were enriched within the set of positively selected genes relative to the genome as a whole. Positively selected genes were linked to the potential selective pressures of nutrient limitation and sea surface temperature based on analysis of gene expression profiles and identification of positively selected genes in subsets of strains from locations with similar environmental conditions. The identification of positively selected genes presents an opportunity to test new hypotheses in natural populations and the laboratory that integrate selected genotypes in T. pseudonana with their associated phenotypes and selective forces. PMID:23097498

  20. Positive selection within a diatom species acts on putative protein interactions and transcriptional regulation.

    PubMed

    Koester, Julie A; Swanson, Willie J; Armbrust, E Virginia

    2013-02-01

    Diatoms are the most species-rich group of microalgae, and their contribution to marine primary production is important on a global scale. Diatoms can form dense blooms through rapid asexual reproduction; mutations acquired and propagated during blooms likely provide the genetic, and thus phenotypic, variability upon which natural selection may act. Positive selection was tested using genome and transcriptome-wide pair-wise comparisons of homologs in three genera of diatoms (Pseudo-nitzschia, Ditylum, and Thalassiosira) that represent decreasing phylogenetic distances. The signal of positive selection was greatest between two strains of Thalassiosira pseudonana. Further testing among seven strains of T. pseudonana yielded 809 candidate genes of positive selection, which are 7% of the protein-coding genes. Orphan genes and genes encoding protein-binding domains and transcriptional regulators were enriched within the set of positively selected genes relative to the genome as a whole. Positively selected genes were linked to the potential selective pressures of nutrient limitation and sea surface temperature based on analysis of gene expression profiles and identification of positively selected genes in subsets of strains from locations with similar environmental conditions. The identification of positively selected genes presents an opportunity to test new hypotheses in natural populations and the laboratory that integrate selected genotypes in T. pseudonana with their associated phenotypes and selective forces. PMID:23097498

  1. Impact of Clean Air Act Regulations on Nitrogen Fate and Transport in the Neuse River Basin

    NASA Astrophysics Data System (ADS)

    Gabriel, M. C.; Knightes, C. D.; Dennis, R. L.; Cooter, E. J.

    2012-12-01

    This study investigated impacts of Clean Air Act Amendment (CAAA) NOx emissions regulations on the fate and transport of nitrogen for two watersheds in the Neuse River Basin, North Carolina, USA from 1990 to 2020. The Soil and Water Assessment Tool (SWAT) and the Community Multi-scale Air Quality (CMAQ) modeling system were used. CMAQ simulated atmospheric chemical transport and nitrogen deposition. This data was entered into SWAT which simulated watershed hydrology and water quality. Two cases were investigated: one that incorporates CAAA regulatory emissions controls in CMAQ simulation (with) and a second case that does not (without). SWAT model results forecasted a 70% decrease in inorganic nitrogen discharge from the Little River watershed and a 50% decrease for the Nahunta watershed by 2020 under the emission control (with) scenario. Denitrification and plant nitrogen uptake played important roles in nitrogen discharge from each watershed. The nitrogen discharge response time following a change in atmospheric nitrogen deposition was 4 years for the Nahunta watershed and 2 years for the Little River watershed. The longer response time for Nahunta is primarily due to a higher percentage of soybean land cover (22.5% [Nahunta]; 1.6% [Little River]). Agricultural land covers had varied nitrogen response times to changes in atmospheric deposition, particularly for soybean, hay and corn. The studied watersheds retained >80% of all nitrogen delivered by agriculture fertilization, biological fixation and atmospheric deposition.

  2. 78 FR 79729 - Integrated Mortgage Disclosures Under the Real Estate Settlement Procedures Act (Regulation X...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ...Sections 1098 and 1100A of the Dodd-Frank Wall Street Reform and Consumer Protection Act (Dodd-Frank Act) direct the Bureau to publish rules and forms that combine certain disclosures that consumers receive in connection with applying for and closing on a mortgage loan under the Truth in Lending Act and the Real Estate Settlement Procedures Act. Consistent with this requirement, the Bureau is......

  3. 21 CFR 1271.10 - Are my HCT/P's regulated solely under section 361 of the PHS Act and the regulations in this part...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) REGULATIONS UNDER CERTAIN OTHER ACTS ADMINISTERED BY THE FOOD AND DRUG ADMINISTRATION HUMAN CELLS, TISSUES... objective intent; (3) The manufacture of the HCT/P does not involve the combination of the cells or tissues... not have a systemic effect and is not dependent upon the metabolic activity of living cells for...

  4. 21 CFR 1271.10 - Are my HCT/P's regulated solely under section 361 of the PHS Act and the regulations in this part...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) REGULATIONS UNDER CERTAIN OTHER ACTS ADMINISTERED BY THE FOOD AND DRUG ADMINISTRATION HUMAN CELLS, TISSUES... objective intent; (3) The manufacture of the HCT/P does not involve the combination of the cells or tissues... not have a systemic effect and is not dependent upon the metabolic activity of living cells for...

  5. ENVIRONMENTALLY SOUND DISPOSAL OF RADIOACTIVE MATERIALS AT A RCRA HAZARDOUS WASTE DISPOSAL FACILITY

    SciTech Connect

    Romano, Stephen; Welling, Steven; Bell, Simon

    2003-02-27

    The use of hazardous waste disposal facilities permitted under the Resource Conservation and Recovery Act (''RCRA'') to dispose of low concentration and exempt radioactive materials is a cost-effective option for government and industry waste generators. The hazardous and PCB waste disposal facility operated by US Ecology Idaho, Inc. near Grand View, Idaho provides environmentally sound disposal services to both government and private industry waste generators. The Idaho facility is a major recipient of U.S. Army Corps of Engineers FUSRAP program waste and received permit approval to receive an expanded range of radioactive materials in 2001. The site has disposed of more than 300,000 tons of radioactive materials from the federal government during the past five years. This paper presents the capabilities of the Grand View, Idaho hazardous waste facility to accept radioactive materials, site-specific acceptance criteria and performance assessment, radiological safety and environmental monitoring program information.

  6. 78 FR 4725 - Escrow Requirements Under the Truth in Lending Act (Regulation Z)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ... persons excluded from coverage by section 1029 of the Dodd-Frank Act). See 76 FR 79768 (Dec. 22, 2011... granted to the Board by the Home Ownership and Equity Protection Act of 1994 (HOEPA). See 73 FR 44522... of sections 1461 and 1462 of the Dodd-Frank Act. 76 FR 11598 (Mar. 2, 2011) (the Board's 2011...

  7. Characterizing cemented TRU waste for RCRA hazardous constituents

    SciTech Connect

    Yeamans, D.R.; Betts, S.E.; Bodenstein, S.A.

    1996-06-01

    Los Alamos National Laboratory (LANL) has characterized drums of solidified transuranic (TRU) waste from four major waste streams. The data will help the State of New Mexico determine whether or not to issue a no-migration variance of the Waste Isolation Pilot Plant (WIPP) so that WIPP can receive and dispose of waste. The need to characterize TRU waste stored at LANL is driven by two additional factors: (1) the LANL RCRA Waste Analysis Plan for EPA compliant safe storage of hazardous waste; (2) the WIPP Waste Acceptance Criteria (WAC) The LANL characterization program includes headspace gas analysis, radioassay and radiography for all drums and solids sampling on a random selection of drums from each waste stream. Data are presented showing that the only identified non-metal RCRA hazardous component of the waste is methanol.

  8. 22 CFR 145.16 - Resource Conservation and Recovery Act.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Resource Conservation and Recovery Act. 145.16... Resource Conservation and Recovery Act. Under the Resource Conservation and Recovery Act (RCRA) (Pub. L. 94... materials identified in guidelines developed by the Environmental Protection Agency (EPA) (40 CFR parts...

  9. 32 CFR 32.49 - Resource Conservation and Recovery Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Resource Conservation and Recovery Act. 32.49....49 Resource Conservation and Recovery Act. Under the Resource Conservation and Recovery Act (RCRA... recycled materials identified in guidelines developed by the Environmental Protection Agency (EPA) (40...

  10. 32 CFR 32.49 - Resource Conservation and Recovery Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Resource Conservation and Recovery Act. 32.49....49 Resource Conservation and Recovery Act. Under the Resource Conservation and Recovery Act (RCRA... recycled materials identified in guidelines developed by the Environmental Protection Agency (EPA) (40...

  11. 22 CFR 145.16 - Resource Conservation and Recovery Act.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Resource Conservation and Recovery Act. 145.16... Resource Conservation and Recovery Act. Under the Resource Conservation and Recovery Act (RCRA) (Pub. L. 94... materials identified in guidelines developed by the Environmental Protection Agency (EPA) (40 CFR parts...

  12. 22 CFR 145.16 - Resource Conservation and Recovery Act.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Resource Conservation and Recovery Act. 145.16... Resource Conservation and Recovery Act. Under the Resource Conservation and Recovery Act (RCRA) (Pub. L. 94... materials identified in guidelines developed by the Environmental Protection Agency (EPA) (40 CFR parts...

  13. 32 CFR 32.49 - Resource Conservation and Recovery Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Resource Conservation and Recovery Act. 32.49....49 Resource Conservation and Recovery Act. Under the Resource Conservation and Recovery Act (RCRA... recycled materials identified in guidelines developed by the Environmental Protection Agency (EPA) (40...

  14. 22 CFR 145.16 - Resource Conservation and Recovery Act.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... materials identified in guidelines developed by the Environmental Protection Agency (EPA) (40 CFR parts 247... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Resource Conservation and Recovery Act. 145.16... Resource Conservation and Recovery Act. Under the Resource Conservation and Recovery Act (RCRA) (Pub. L....

  15. 22 CFR 145.16 - Resource Conservation and Recovery Act.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... materials identified in guidelines developed by the Environmental Protection Agency (EPA) (40 CFR parts 247... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Resource Conservation and Recovery Act. 145.16... Resource Conservation and Recovery Act. Under the Resource Conservation and Recovery Act (RCRA) (Pub. L....

  16. 78 FR 60381 - Amendments to the 2013 Mortgage Rules Under the Equal Credit Opportunity Act (Regulation B), Real...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-01

    ... February 15, 2013, at 78 FR 11280. FOR FURTHER INFORMATION CONTACT: Whitney Patross, Attorney; Richard... Under the Truth in Lending Act (Regulation Z), 78 FR 4726 (Jan. 22, 2013) (2013 Escrows Final Rule...), 78 FR 6856 (Jan. 31, 2013) (2013 HOEPA Final Rule), and Ability-to-Repay and Qualified...

  17. 9 CFR 331.3 - States designated under paragraph 301(c) of the Act; application of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false States designated under paragraph 301(c) of the Act; application of regulations. 331.3 Section 331.3 Animals and Animal Products FOOD... DESIGNATED STATES AND TERRITORIES; AND FOR DESIGNATION OF ESTABLISHMENTS WHICH ENDANGER PUBLIC HEALTH AND...

  18. 9 CFR 381.222 - States designated under paragraph 5(c) of the Act; application of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false States designated under paragraph 5(c) of the Act; application of regulations. 381.222 Section 381.222 Animals and Animal Products FOOD... Designating Establishments With Operations Which Would Clearly Endanger the Public Health; Disposition...

  19. 76 FR 28966 - Revisions to Oil Pipeline Regulations Pursuant to the Energy Policy Act of 1992; Notice of Annual...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Revisions to Oil Pipeline Regulations Pursuant to the Energy Policy Act of 1992; Notice of Annual Change in the Producer Price Index for Finished Goods The...

  20. 29 CFR 102.117 - Freedom of Information Act Regulations: Board materials and formal documents available for public...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., the cost of conducting computer searches for information and for providing information in electronic... 29 Labor 2 2010-07-01 2010-07-01 false Freedom of Information Act Regulations: Board materials and... for response; appeal from denial of request; fees for document search and duplication; files...

  1. 77 FR 33635 - Amendment to the Bank Secrecy Act Regulations-Requirement That Clerks of Court Report Certain...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-07

    ...\\ 66 FR 67680 (December 31, 2001), codified at 31 CFR 1010.330. \\7\\ 26 CFR 1.6050I-1. As amended... Financial Crimes Enforcement Network 31 CFR Part 1010 RIN 1506-AB17 Amendment to the Bank Secrecy Act Regulations--Requirement That Clerks of Court Report Certain Currency Transactions AGENCY: Financial...

  2. 78 FR 63408 - Petition To Amend Animal Welfare Act Regulations To Prohibit Public Contact With Big Cats, Bears...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-24

    ... 5, 2013 (78 FR 47215) is reopened. We will consider all comments that we receive on or before.... SUPPLEMENTARY INFORMATION: On August 5, 2013, we published in the Federal Register (78 FR 47215-47217, Docket No... Animal Welfare Act Regulations To Prohibit Public Contact With Big Cats, Bears, and Nonhuman...

  3. 78 FR 23171 - Amendments to the 2013 Escrows Final Rule Under the Truth in Lending Act (Regulation Z)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-18

    ... loans made in ``rural'' or ``underserved'' areas. \\1\\ 78 FR 4726 (Jan. 22, 2013). \\2\\ The other rules...) (2013 ATR Final Rule), 78 FR 6407; High-Cost Mortgages and Homeownership Counseling Amendments to the... Settlement Procedures Act (Regulation X) (2013 HOEPA Final Rule), 78 FR 6855; Disclosure and...

  4. 9 CFR 381.222 - States designated under paragraph 5(c) of the Act; application of regulations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false States designated under paragraph 5(c) of the Act; application of regulations. 381.222 Section 381.222 Animals and Animal Products FOOD... Designating Establishments With Operations Which Would Clearly Endanger the Public Health; Disposition...

  5. 9 CFR 331.3 - States designated under paragraph 301(c) of the Act; application of regulations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...(c) of the Act; application of regulations. 331.3 Section 331.3 Animals and Animal Products FOOD... circuit supervisor (showing any modifications required by the circuit supervisor) to the Labels and Packaging Staff, Meat and Poultry Inspection, Food Safety and Inspection Service, USDA, Washington, DC...

  6. 9 CFR 381.222 - States designated under paragraph 5(c) of the Act; application of regulations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) of the Act; application of regulations. 381.222 Section 381.222 Animals and Animal Products FOOD... modifications required by the Circuit Supervisor) to the Labels and Packaging Staff, Meat and Poultry Inspection Food Safety and Inspection Service, U.S. Department of Agriculture, Washington, DC 20250,...

  7. 9 CFR 331.3 - States designated under paragraph 301(c) of the Act; application of regulations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...(c) of the Act; application of regulations. 331.3 Section 331.3 Animals and Animal Products FOOD... circuit supervisor (showing any modifications required by the circuit supervisor) to the Labels and Packaging Staff, Meat and Poultry Inspection, Food Safety and Inspection Service, USDA, Washington, DC...

  8. Application of TALEs, CRISPR/Cas and sRNAs as trans-acting regulators in prokaryotes.

    PubMed

    Copeland, Matthew F; Politz, Mark C; Pfleger, Brian F

    2014-10-01

    The last several years have witnessed an explosion in the understanding and use of novel, versatile trans-acting elements. TALEs, CRISPR/Cas, and sRNAs can be easily fashioned to bind any specific sequence of DNA (TALEs, CRISPR/Cas) or RNA (sRNAs) because of the simple rules governing their interactions with nucleic acids. This unique property enables these tools to repress the expression of genes at the transcriptional or post-transcriptional levels, respectively, without prior manipulation of cis-acting and/or chromosomal target DNA sequences. These tools are now being harnessed by synthetic biologists, particularly those in the eukaryotic community, for genome-wide regulation, editing, or epigenetic studies. Here we discuss the exciting opportunities for using TALEs, CRISPR/Cas, and sRNAs as synthetic trans-acting regulators in prokaryotes.

  9. Employee Retirement Income Security Act of 1974: rules and regulations for administration and enforcement; claims procedure. Pension and Welfare Benefits Administration, Labor. Final regulation.

    PubMed

    2000-11-21

    This document contains a final regulation revising the minimum requirements for benefit claims procedures of employee benefit plans covered by Title I of the Employee Retirement Income Security Act of 1974 (ERISA or the Act). The regulation establishes new standards for the processing of claims under group health plans and plans providing disability benefits and further clarifies existing standards for all other employee benefit plans. The new standards are intended to ensure more timely benefit determinations, to improve access to information on which a benefit determination is made, and to assure that participants and beneficiaries will be afforded a full and fair review of denied claims. When effective, the regulation will affect participants and beneficiaries of employee benefit plans, employers who sponsor employee benefit plans, plan fiduciaries, and others who assist in the provision of plan benefits, such as third-party benefits administrators and health service providers or health maintenance organizations that provide benefits to participants and beneficiaries of employee benefit plans.

  10. Mobilization plan for the Y-12 9409-5 tank storage facility RCRA closure plan. Final report. Revision 1

    SciTech Connect

    1993-11-01

    This mobilization plan identifies the activities and equipment necessary to begin the field sampling for the Oak Ridge Y-12 9409-5 Diked Tank Storage Facility (DTSF) Resource Conservation and Recovery Act (RCRA) closure. Elements of the plan outline the necessary components of each mobilization task and identify whether SAIC or the Martin Marietta Energy Systems, Inc. Y-12 Environmental Restoration Division will be responsible for task coordination. Field work will be conducted in two phases: mobilization phase and soil sampling phase. Training and medical monitoring, access, permits and passes, decontamination/staging area, equipment, and management are covered in this document.

  11. Environmental Protection Agency update on mixed waste regulations

    SciTech Connect

    Wolfe, A.

    1989-11-01

    This paper is divided into discussion of the following four basic areas: (1) dual regulation; (2) the state role; (3) an overview of current agency activities; and (4) current issues. The first area, dual regulation of mixed waste, requires the cooperation between regulatory agencies, whether federal or state, for managing the chemical and radioactive aspects of mixed waste. Dual or joint regulation of mixed waste is now a well established fact. The second area is state involvement. Dual regulation involves not only the EPA, DOE, and NRC, but also state authorities. The Resource Conservation and Recovery Act (RCRA) is implemented for the most part by the individual states. Congress intended that the states be the primary implementers of RCRA and created provisions in the Act to authorize state programs. The third area discussed in this paper is concerned with EPA`s progress on current issues. EPA has progressed on several promises to create strong centralized guidance. Fourth and finally, there are many issues outstanding and some may have direct specific significant impact on DOE facility operations. Perhaps the biggest outstanding issue is how the land disposal restrictions will affect the treatment, storage, and disposal of mixed waste at DOE facilities.

  12. Resource Conservation and Recovery Act industrial site environmental restoration site characterization report - area 6 steam cleaning effluent ponds

    SciTech Connect

    1996-09-01

    The Area 6 North and South Steam Cleaning Effluent Ponds (SCEPs) are historic disposal units located at the Nevada Test Site (NTS) in Nye County, Nevada. The NTS is operated by the U.S. Department of Energy, Nevada Operations Office (DOE/NV) which has been required by the Nevada Division of Environmental Protection (NDEP) to characterize the site under the requirements of the Resource Conservation and Recovery Act (RCRA) Part B Permit for the NTS and Title 40 Code of Federal Regulations, Part 265.

  13. 76 FR 10527 - Regulatory Flexibility Act: Section 610 Review of National Organic Program Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-25

    ... regulations implementing the National Organic Program (NOP) were published December 21, 2000 (65 FR 80548... FR 14827), its schedule to review certain regulations, including the NOP regulations, under criteria... Organic Program Regulations AGENCY: Agricultural Marketing Service, USDA. ACTION: Review and request...

  14. Borehole Data Package for Calendar Year 2000 - 2001 RCRA Wells at Single-Shell Tank Waste Management Area S-SX

    SciTech Connect

    Horton, Duane G.; Johnson, Vernon G.

    2001-08-15

    Six new resource conservation and Recovery Act (RCRA) groundwater monitoring wells were installed at the single-shell tank farm Waste Management Area S-SX in July 2000 through March 2001 in partial fulfillment of Tri-Party Agreement milestones M-24-00L and M-24-00M. This document describes the drilling, construction, sampling and analyses of samples from the wells.

  15. 75 FR 12377 - Native American Graves Protection and Repatriation Act Regulations-Disposition of Culturally...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-15

    ... first rules to implement the Act on December 4, 1995 (43 CFR part 10, 60 FR 62158). --We published rules for assessing civil penalties under the Act on April 3, 2003 (43 CFR 10.12, 68 FR 16354). --We....13, 72 FR 13189). --We are publishing this rule today. --We are developing additional rules to...

  16. 75 FR 38684 - Federal Acquisition Regulation; FAR Case 2010-008, Recovery Act Subcontract Reporting Procedures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-02

    ... (DoD), General Services Administration (GSA), and National Aeronautics and Space Administration (NASA... 2009-009 in the Federal Register, (74 FR 14639) as an interim rule amending the FAR to implement section 1512 of the Recovery Act, which requires contractors to report on their use of Recovery Act...

  17. 75 FR 46859 - Lacey Act Implementation Plan; Definitions for Exempt and Regulated Articles

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-04

    ... addition, Section 3 of the Lacey Act, as amended, makes it unlawful, beginning December 15, 2008, to import... is being phased in, as described in two notices we published in the Federal Register (74 FR 5911-5913 and 74 FR 45415- 45418, Docket No. APHIS-2008-0119). Under the Act, ``Plant'' means: ``Any wild...

  18. Cis elements and trans-acting factors affecting regulation of a nonphotosynthetic light-regulated gene for chloroplast glutamine synthetase.

    PubMed Central

    Tjaden, G; Edwards, J W; Coruzzi, G M

    1995-01-01

    The glutamine synthetase (GS) gene family in pea (Pisum sativum) consists of four nuclear genes encoding distinct isoenzymes. Molecular studies have show that the GS2 gene encoding chloroplast-localized GS is expected in specific cell types and is regulated by diverse factors such as light and photorespiration. Here, we present the nucleotide sequence of the pea GS2 gene promoter. To identify the elements involved in regulation of GS2 expression, GS2 promoter-deletion analyses were performed using GS2-GUS fusions in tobacco (Nicotiana tabacum). This analysis revealed that the GS2 transit peptide is not required for mesophyll cell-specific expression of beta-glucuronidase (GUS). GUS activity was induced 2- to 4-fold in light-grown versus etiolated T1 seedlings. However, high levels of GUS activity were observed in etiolated seedlings. This observation demonstrated that regulation of expression of GS2, a nonphotosynthetic light-regulated gene, involves additional factors. A 323-bp GS2 promoter sequence is sufficient to confer light regulation to the GUS reporter gene in leaves of mature transgenic tobacco. Light-regulated expression of this pea gene promoter is observed in both tobacco and Arabidopsis, suggesting that the regulatory elements are conserved. Gel-shift analysis detected DNA-protein complexes formed with potential transcription elements within this short, light-responsive GS2 promoter fragment. PMID:7630938

  19. 25 CFR 101.10 - Federal Reserve Regulation Z and Fair Credit Reporting Act.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... subject to the provisions of Federal Reserve Regulation Z (Truth In Lending, 12 CFR part 226; Pub. L. 91... 25 Indians 1 2011-04-01 2011-04-01 false Federal Reserve Regulation Z and Fair Credit Reporting... ACTIVITIES LOANS TO INDIANS FROM THE REVOLVING LOAN FUND § 101.10 Federal Reserve Regulation Z and...

  20. 25 CFR 101.10 - Federal Reserve Regulation Z and Fair Credit Reporting Act.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... subject to the provisions of Federal Reserve Regulation Z (Truth In Lending, 12 CFR part 226; Pub. L. 91... 25 Indians 1 2010-04-01 2010-04-01 false Federal Reserve Regulation Z and Fair Credit Reporting... ACTIVITIES LOANS TO INDIANS FROM THE REVOLVING LOAN FUND § 101.10 Federal Reserve Regulation Z and...

  1. GP Supervisors' Experience in Supporting Self-Regulated Learning: A Balancing Act

    ERIC Educational Resources Information Center

    Sagasser, Margaretha H.; Kramer, Anneke W. M.; van Weel, Chris; van der Vleuten, Cees P. M.

    2015-01-01

    Self-regulated learning is essential for professional development and lifelong learning. As self-regulated learning has many inaccuracies, the need to support self-regulated learning has been recommended. Supervisors can provide such support. In a prior study trainees reported on the variation in received supervisor support. This study aims at…

  2. Performance Demonstration Program Plan for RCRA Constituent Analysis of Solidified Wastes

    SciTech Connect

    Carlsbad Field Office

    2006-09-21

    The Performance Demonstration Program (PDP) for Resource Conservation and Recovery Act (RCRA) constituents distributes test samples for analysis of volatile organic compounds (VOCs), semivolatile organic compounds (SVOCs), and metals in solid matrices. Each distribution of test samples is termed a PDP cycle. These evaluation cycles provide an objective measure of the reliability of measurements performed for transuranic (TRU) waste characterization. The primary documents governing the conduct of the PDP are the Quality Assurance Program Document (QAPD; DOE/CBFO-94-1012) and the Waste Isolation Pilot Plant (WIPP) Waste Analysis Plan (WAP) contained in the Hazardous Waste Facility Permit (NM4890139088-TSDF) issued by the New Mexico Environment Department. The WAP requires participation in the PDP; the PDP must comply with the QAPD and the WAP. This plan implements the general requirements of the QAPD and the applicable requirements of the WAP for the RCRA PDP. Participating laboratories demonstrate acceptable performance by successfully analyzing single- blind performance evaluation samples (subsequently referred to as PDP samples) according to the criteria established in this plan. PDP samples are used as an independent means to assess laboratory performance regarding compliance with the WAP quality assurance objectives (QAOs). The concentrations of analytes in the PDP samples address levels of regulatory concern and encompass the range of concentrations anticipated in waste characterization samples. The WIPP requires analyses of homogeneous solid wastes to demonstrate compliance with regulatory requirements. These analyses must be performed by laboratories that demonstrate acceptable performance in this PDP. These analyses are referred to as WIPP analyses, and the samples on which they are performed are referred to as WIPP samples. Participating laboratories must analyze PDP samples using the same procedures used for WIPP samples.

  3. Foundations for the Future of Alberta's Metis Settlements. Report of the MacEwan Joint Metis-Government Committee to Review the Metis Betterment Act and Regulations.

    ERIC Educational Resources Information Center

    Alberta Ministry of Municipal Affairs, Edmonton.

    Prepared as a working document for officials of the Alberta (Canada) government, this report reviews the Metis Betterment Act and regulations made under the Act with one goal being to ensure that any proposals for a new Act would place the major responsibility for the political, social, economic, and cultural development of the settlements firmly…

  4. 25 CFR 309.1 - How do the regulations in this part carry out the Indian Arts and Crafts Act of 1990?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Arts and Crafts Act of 1990? 309.1 Section 309.1 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR PROTECTION OF INDIAN ARTS AND CRAFTS PRODUCTS § 309.1 How do the regulations in this part carry out the Indian Arts and Crafts Act of 1990? These regulations define the nature and Indian...

  5. The Regulation of Medical Computer Software as a “Device” under the Food, Drug, and Cosmetic Act

    PubMed Central

    Brannigan, Vincent

    1986-01-01

    Recent developments in computer software have raised the possibility that federal regulators may claim to control medical computer software as a “device” under the Food, Drug and Cosmetic Act. The purpose of this paper is to analyze the FDCA to determine whether computer software is included in the statutory scheme, examine constitutional arguments relating to computer software, and discuss regulatory principles that should be taken into account when deciding appropriate regulation. This paper is limited to computer program output used by humans in deciding appropriate medical therapy for a patient.

  6. The regulation of hazardous air pollutants under the Clean Air Act Amendments of 1990: Effects on the Portland cement industry

    SciTech Connect

    Mikols, E.H.; Dougherty, A.

    1996-07-01

    Title III of the 1990 Clean Air Act Amendments (CAAA) addresses the control of hazardous air pollutants (HAPs) from major sources of air pollution in the US. In the CAAA, Congress defined 189 compounds as hazardous air pollutants in need of additional control by the Environmental Protection Agency (EPA). Congress directed EPA to identify the major source categories which emit HAPs and to prepare regulations that would reduce and control future HAP emissions. This paper outlines the activities undertaken by EPA to regulate HAP emissions from Portland cement plants and the program developed by the Portland cement manufacturing industry to cope with Title III.

  7. DAY NEUTRAL FLOWERING does not act through GIGANTEA and FKF1 to regulate CONSTANS expression and flowering time.

    PubMed

    Morris, Karl; Jackson, Stephen P

    2010-09-01

    The regulation of CONSTANS (CO) gene expression and protein levels is the critical factor in determining a plant's response to photoperiod, flowering is induced when high levels of CO protein are present in the light. The regulation of CO transcription is mediated in part by GIGANTEA (GI), FKF1 and the CYCLING DOF FACTORS (CDFs) and factors affecting the levels of these proteins will also affect CO expression. The DAY NEUTRAL FLOWERING (DNF) protein is an E3 ligase involved in repressing CO expression in the early part of the day. In this article we present evidence to support the argument that DNF is not acting through the GI/FKF1/CDF regulatory mechanism to repress CO expression, but that it acts on another transcriptional activator of CO.

  8. Drinking water regulations under the Safe Drinking Water Act. Fact sheet

    SciTech Connect

    Not Available

    1990-12-01

    The fact sheet describes the requirements covered under the 1986 amendments to the Safe Drinking Water Act. Levels of various contaminants (including radio nuclides) are explained. Also discussed are the Surface Water Treatment Rule and the Total Coliforms Rule.

  9. Ligand recognition by ActR, a TetR-like regulator of actinorhodin export.

    PubMed

    Tahlan, Kapil; Yu, Zhou; Xu, Ye; Davidson, Alan R; Nodwell, Justin R

    2008-11-21

    TetR-like transcriptional repressors interact with small-molecule ligands to control many facets of prokaryotic biology, including clinical antibiotic resistance. ActR is a TetR-like protein encoded in the biosynthetic gene cluster for the antibiotic actinorhodin and controls the expression of two actinorhodin exporters. We showed previously that actinorhodin and its precursor 4-dihydro-9-hydroxy-1-methyl-10-oxo-3-H-naphtho-[2,3-c]-pyran-3-(S)-acetic acid can bind ActR and prevent its interaction with DNA. Here, we compare ActR's interaction with naturally occurring and synthetic molecules to show that pathway intermediates bind to ActR 5- to 10-fold more tightly than actinorhodin itself, consistent with our suggestion that they are the biologically relevant triggers for actinorhodin export. We also find that the ligand-binding cavity of this protein can accommodate a surprisingly large diversity of ligands, many of which can release ActR from DNA in vitro and in vivo. These data suggest that the actR locus could be activated by, and perhaps adapted to confer resistance to other antibiotics.

  10. Regulation of caulimovirus gene expression and the involvement of cis-acting elements on both viral transcripts.

    PubMed

    Scholthof, H B; Wu, F C; Gowda, S; Shepherd, R J

    1992-09-01

    In a further analysis of gene regulation of figwort mosaic virus (FMV), a caulimovirus, we studied transient gene expression with modified viral genomes in Nicotiana edwardsonii cell suspension protoplasts. The results demonstrated that the presence of the promoter for the full-length RNA interferes with expression from the separate downstream promoter for gene VI. In addition, expression of gene VI was inhibited by cis-acting sequences within gene VI itself. Both inhibitory effects could be partially relieved by coelectroporation with a plasmid that produces gene VI protein, demonstrating that expression of gene VI is transactivated by its own product. Subsequent expression studies with partially redundant FMV plasmids containing a reporter gene in frame with gene IV showed that efficient transactivation of CAT expression relies on a cis-acting element inside the downstream gene VI. Insertions of a transcriptional terminator upstream of the cis-acting element for premature termination of transcription showed that the cis-acting region is not a DNA element but is active only as a feature of the RNA transcript. We conclude that the cis-acting element, together with the transacting gene VI product, enhances expression of all major genes, including gene VI, from the polycistronic mRNA and the separate mRNA for gene VI.

  11. 77 FR 54818 - Polychlorinated Biphenyls (PCBs): Revisions to Manifesting Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-06

    ... affected entities Electric Power Distribution.... 221122 Generators of PCB waste. Transportation and... requirements, which uses the Resource Conservation and Recovery Act (RCRA) Uniform Hazardous Waste Manifest... manifesting requirements for PCBs under TSCA to the manifesting requirements for hazardous waste under...

  12. 40 CFR 270.67 - RCRA standardized permits for storage and treatment units.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false RCRA standardized permits for storage and treatment units. 270.67 Section 270.67 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Special Forms of Permits § 270.67 RCRA standardized permits for storage and treatment units....

  13. 40 CFR 271.24 - Interim authorization under section 3006(g) of RCRA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... revised Corrective Action Management Unit rule (except 40 CFR 264.555) promulgated on January 22, 2002 and... 3006(g) of RCRA. 271.24 Section 271.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Requirements for Final Authorization § 271.24 Interim authorization under section 3006(g) of RCRA. (a)...

  14. 40 CFR 270.250 - What is a RCRA standardized permit?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... you to manage hazardous waste. It is issued under 40 CFR part 124, subpart G and subpart J of this... 40 Protection of Environment 28 2013-07-01 2013-07-01 false What is a RCRA standardized permit... WASTES (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM RCRA...

  15. 40 CFR 271.24 - Interim authorization under section 3006(g) of RCRA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... revised Corrective Action Management Unit rule (except 40 CFR 264.555) promulgated on January 22, 2002 and... 3006(g) of RCRA. 271.24 Section 271.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Requirements for Final Authorization § 271.24 Interim authorization under section 3006(g) of RCRA. (a)...

  16. 40 CFR 124.200 - What is a RCRA standardized permit?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... facility, that EPA has promulgated in 40 CFR part 267 (Standards for Owners and Operators of Hazardous... 40 Protection of Environment 23 2012-07-01 2012-07-01 false What is a RCRA standardized permit... PROGRAMS PROCEDURES FOR DECISIONMAKING Procedures for RCRA Standardized Permit General Information...

  17. 40 CFR 270.250 - What is a RCRA standardized permit?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... you to manage hazardous waste. It is issued under 40 CFR part 124, subpart G and subpart J of this... 40 Protection of Environment 27 2014-07-01 2014-07-01 false What is a RCRA standardized permit... WASTES (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM RCRA...

  18. 40 CFR 270.67 - RCRA standardized permits for storage and treatment units.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false RCRA standardized permits for storage and treatment units. 270.67 Section 270.67 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Special Forms of Permits § 270.67 RCRA standardized permits for storage and treatment units....

  19. 40 CFR 270.250 - What is a RCRA standardized permit?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... you to manage hazardous waste. It is issued under 40 CFR part 124, subpart G and subpart J of this... 40 Protection of Environment 26 2010-07-01 2010-07-01 false What is a RCRA standardized permit... WASTES (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM RCRA...

  20. 40 CFR 124.200 - What is a RCRA standardized permit?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... facility, that EPA has promulgated in 40 CFR part 267 (Standards for Owners and Operators of Hazardous... 40 Protection of Environment 22 2011-07-01 2011-07-01 false What is a RCRA standardized permit... PROGRAMS PROCEDURES FOR DECISIONMAKING Procedures for RCRA Standardized Permit General Information...

  1. 40 CFR 124.200 - What is a RCRA standardized permit?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... facility, that EPA has promulgated in 40 CFR part 267 (Standards for Owners and Operators of Hazardous... 40 Protection of Environment 23 2013-07-01 2013-07-01 false What is a RCRA standardized permit... PROGRAMS PROCEDURES FOR DECISIONMAKING Procedures for RCRA Standardized Permit General Information...

  2. 40 CFR 124.200 - What is a RCRA standardized permit?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... facility, that EPA has promulgated in 40 CFR part 267 (Standards for Owners and Operators of Hazardous... 40 Protection of Environment 21 2010-07-01 2010-07-01 false What is a RCRA standardized permit... PROGRAMS PROCEDURES FOR DECISIONMAKING Procedures for RCRA Standardized Permit General Information...

  3. 40 CFR 270.67 - RCRA standardized permits for storage and treatment units.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false RCRA standardized permits for storage and treatment units. 270.67 Section 270.67 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Special Forms of Permits § 270.67 RCRA standardized permits for storage and treatment units....

  4. 40 CFR 270.67 - RCRA standardized permits for storage and treatment units.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false RCRA standardized permits for storage and treatment units. 270.67 Section 270.67 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Special Forms of Permits § 270.67 RCRA standardized permits for storage and treatment units....

  5. 40 CFR 270.67 - RCRA standardized permits for storage and treatment units.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false RCRA standardized permits for storage and treatment units. 270.67 Section 270.67 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Special Forms of Permits § 270.67 RCRA standardized permits for storage and treatment units....

  6. 40 CFR 271.24 - Interim authorization under section 3006(g) of RCRA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... revised Corrective Action Management Unit rule (except 40 CFR 264.555) promulgated on January 22, 2002 and... 3006(g) of RCRA. 271.24 Section 271.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Requirements for Final Authorization § 271.24 Interim authorization under section 3006(g) of RCRA. (a)...

  7. 40 CFR 271.24 - Interim authorization under section 3006(g) of RCRA.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... revised Corrective Action Management Unit rule (except 40 CFR 264.555) promulgated on January 22, 2002 and... 3006(g) of RCRA. 271.24 Section 271.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Requirements for Final Authorization § 271.24 Interim authorization under section 3006(g) of RCRA. (a)...

  8. 40 CFR 270.250 - What is a RCRA standardized permit?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... you to manage hazardous waste. It is issued under 40 CFR part 124, subpart G and subpart J of this... 40 Protection of Environment 28 2012-07-01 2012-07-01 false What is a RCRA standardized permit... WASTES (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM RCRA...

  9. 40 CFR 124.200 - What is a RCRA standardized permit?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... facility, that EPA has promulgated in 40 CFR part 267 (Standards for Owners and Operators of Hazardous... 40 Protection of Environment 22 2014-07-01 2013-07-01 true What is a RCRA standardized permit? 124... PROGRAMS PROCEDURES FOR DECISIONMAKING Procedures for RCRA Standardized Permit General Information...

  10. 40 CFR 271.24 - Interim authorization under section 3006(g) of RCRA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... revised Corrective Action Management Unit rule (except 40 CFR 264.555) promulgated on January 22, 2002 and... 3006(g) of RCRA. 271.24 Section 271.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Requirements for Final Authorization § 271.24 Interim authorization under section 3006(g) of RCRA. (a)...

  11. 40 CFR 270.250 - What is a RCRA standardized permit?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... you to manage hazardous waste. It is issued under 40 CFR part 124, subpart G and subpart J of this... 40 Protection of Environment 27 2011-07-01 2011-07-01 false What is a RCRA standardized permit... WASTES (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM RCRA...

  12. Quarterly RCRA Groundwater Monitoring Data for the Period April Through June 2006

    SciTech Connect

    Hartman, Mary J.

    2006-11-01

    This report provides information about RCRA groundwater monitoring for the period April through June 2006. Seventeen RCRA sites were sampled during the reporting quarter. Sampled sites include seven monitored under groundwater indicator evaluation (''detection'') programs, eight monitored under groundwater quality assessment programs, and two monitored under final-status programs.

  13. DOSE ASSESSMENTS FROM THE DISPOSAL OF LOW-ACTIVITY WASTES IN RCRA-C DISPOSAL CELLS

    EPA Science Inventory

    Modeling the long-term performance of the RCRA-C disposal cell and potential doses to off-site receptors is used to derive maximum radionuclide specific concentrations in the wastes that would enable these wastes to be disposed of safely using the RCRA-C disposal cell technology....

  14. RCRA Summary Document for the David Witherspoon 1630 Site, Knoxville, Tennessee

    SciTech Connect

    Pfeffer, J.

    2008-06-10

    , cylinders, and cable) and populations of debris type items (e.g., piles of bricks, small scrap metal, roofing material, scaffolding, and shelving) that are located throughout the DWI 1630 site. The project also generates an additional small volume of secondary waste [e.g., personal protective equipment (PPE), and miscellaneous construction waste] that is bagged and included in bulk soil shipments to the EMWMF. The Waste Acceptance Criteria (WAC) for the EMWMF does not allow for material that does not meet the Resource Conservation and Recovery Act (RCRA) Land Disposal Restrictions (LDRs). The waste being excavated in certain areas of the DWI 1630 site contained soil that did not meet RCRA LDR criteria; therefore this waste had to be segregated for treatment or alternate disposal offsite. This document identifies the approach taken by the DWI 1630 project to further characterize the areas identified during the Phase II Remedial Investigation (RI) as potentially containing RCRA-characteristic waste. This document also describes the methodology used to determine excavation limits for areas determined to be RCRA waste, post excavation sampling, and the treatment and disposal of this material.

  15. 75 FR 51420 - Removing Regulations Implementing the Fish and Wildlife Conservation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-20

    ... implementing regulations (50 CFR 83) in the May 6, 2010, Federal Register (75 FR 24862) and invited public... with Native American Tribal Governments'' (59 FR 22951), E.O. 13175, and 512 DM 2. We have determined... Fish and Wildlife Service 50 CFR Part 83 RIN 1018-AX00 Removing Regulations Implementing the Fish...

  16. 76 FR 78483 - S.A.F.E. Mortgage Licensing Act (Regulations G & H)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-19

    ... Insurance Corporation, and the Department of Housing and Urban Development for the Secure and Fair... regulated by the Farm Credit Administration. This interim final rule does not impose any new substantive... by a Federal banking agency, or employees of institutions regulated by the Farm Credit...

  17. 76 FR 57940 - Revision of Department of Justice Freedom of Information Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ..., the regulations will be updated to reflect developments in the case law and to include current cost... NRPM published on March 21, 2011 (76 FR 15236), closed on April 20, 2011. This document reopens the... revising its existing regulations under the FOIA. (See 76 FR 15236.) The rule proposed to amend...

  18. 24 CFR 84.16 - Resource Conservation and Recovery Act.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Resource Conservation and Recovery... Resource Conservation and Recovery Act. Under the Resource Conservation and Recovery Act (RCRA) (Pub. L. 94... guidelines developed by the Environmental Protection Agency (EPA) (40 CFR parts 247 through 254)....

  19. 36 CFR 1210.16 - Resource Conservation and Recovery Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false Resource Conservation and... Conservation and Recovery Act. Under the Resource Conservation and Recovery Act ((RCRA) (Pub. L. 94-580... identified in guidelines developed by the Environmental Protection Agency (EPA) (40 CFR Parts 247 through...

  20. 36 CFR 1210.16 - Resource Conservation and Recovery Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false Resource Conservation and... Conservation and Recovery Act. Under the Resource Conservation and Recovery Act ((RCRA) (Pub. L. 94-580... identified in guidelines developed by the Environmental Protection Agency (EPA) (40 CFR Parts 247 through...

  1. 24 CFR 84.16 - Resource Conservation and Recovery Act.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Resource Conservation and Recovery... Resource Conservation and Recovery Act. Under the Resource Conservation and Recovery Act (RCRA) (Pub. L. 94... guidelines developed by the Environmental Protection Agency (EPA) (40 CFR parts 247 through 254)....

  2. 24 CFR 84.16 - Resource Conservation and Recovery Act.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Resource Conservation and Recovery... Resource Conservation and Recovery Act. Under the Resource Conservation and Recovery Act (RCRA) (Pub. L. 94... guidelines developed by the Environmental Protection Agency (EPA) (40 CFR parts 247 through 254)....

  3. 24 CFR 84.16 - Resource Conservation and Recovery Act.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... guidelines developed by the Environmental Protection Agency (EPA) (40 CFR parts 247 through 254). Accordingly... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Resource Conservation and Recovery... Resource Conservation and Recovery Act. Under the Resource Conservation and Recovery Act (RCRA) (Pub. L....

  4. 24 CFR 84.16 - Resource Conservation and Recovery Act.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... guidelines developed by the Environmental Protection Agency (EPA) (40 CFR parts 247 through 254). Accordingly... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Resource Conservation and Recovery... Resource Conservation and Recovery Act. Under the Resource Conservation and Recovery Act (RCRA) (Pub. L....

  5. 36 CFR 1210.16 - Resource Conservation and Recovery Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... identified in guidelines developed by the Environmental Protection Agency (EPA) (40 CFR Parts 247 through 254... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Resource Conservation and... Conservation and Recovery Act. Under the Resource Conservation and Recovery Act ((RCRA) (Pub. L....

  6. Twenty Years of the Dietary Supplement Health and Education Act--How Should Dietary Supplements Be Regulated?

    PubMed

    Wallace, Taylor C

    2015-08-01

    The Dietary Supplement Health and Education Act (DSHEA) of 1994 defines the FDA's statutory authority to regulate dietary supplement products in the United States. The dietary supplement industry has rapidly expanded since 1994, presenting an obvious need for "DSHEA 2.0." Current regulations surrounding dietary supplements have been increasingly and reasonably scrutinized, given their widespread use by over one-half of the US population as well as highly publicized safety concerns over the past 20 y. As the market continues to expand and evolve, so too must the laws that protect consumers from potential harm and misleading communication. This article is meant to begin a scientific dialogue on how regulations may be improved to provide both ease of access and safer products to the consumer by focusing on 4 topics: premarket approval, label claims, current Good Manufacturing Practices, and adverse event reporting. PMID:26063064

  7. Twenty Years of the Dietary Supplement Health and Education Act--How Should Dietary Supplements Be Regulated?

    PubMed

    Wallace, Taylor C

    2015-08-01

    The Dietary Supplement Health and Education Act (DSHEA) of 1994 defines the FDA's statutory authority to regulate dietary supplement products in the United States. The dietary supplement industry has rapidly expanded since 1994, presenting an obvious need for "DSHEA 2.0." Current regulations surrounding dietary supplements have been increasingly and reasonably scrutinized, given their widespread use by over one-half of the US population as well as highly publicized safety concerns over the past 20 y. As the market continues to expand and evolve, so too must the laws that protect consumers from potential harm and misleading communication. This article is meant to begin a scientific dialogue on how regulations may be improved to provide both ease of access and safer products to the consumer by focusing on 4 topics: premarket approval, label claims, current Good Manufacturing Practices, and adverse event reporting.

  8. 40 CFR 124.203 - How may I switch from my individual RCRA permit to a standardized permit?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... RCRA permit to a standardized permit? 124.203 Section 124.203 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS PROCEDURES FOR DECISIONMAKING Procedures for RCRA Standardized Permit Applying for A Standardized Permit § 124.203 How may I switch from my individual RCRA permit to...

  9. 40 CFR 124.203 - How may I switch from my individual RCRA permit to a standardized permit?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... RCRA permit to a standardized permit? 124.203 Section 124.203 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS PROCEDURES FOR DECISIONMAKING Procedures for RCRA Standardized Permit Applying for A Standardized Permit § 124.203 How may I switch from my individual RCRA permit to...

  10. 40 CFR 124.203 - How may I switch from my individual RCRA permit to a standardized permit?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... RCRA permit to a standardized permit? 124.203 Section 124.203 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS PROCEDURES FOR DECISIONMAKING Procedures for RCRA Standardized Permit Applying for A Standardized Permit § 124.203 How may I switch from my individual RCRA permit to...

  11. 40 CFR 124.203 - How may I switch from my individual RCRA permit to a standardized permit?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... RCRA permit to a standardized permit? 124.203 Section 124.203 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS PROCEDURES FOR DECISIONMAKING Procedures for RCRA Standardized Permit Applying for A Standardized Permit § 124.203 How may I switch from my individual RCRA permit to...

  12. 40 CFR 124.203 - How may I switch from my individual RCRA permit to a standardized permit?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... RCRA permit to a standardized permit? 124.203 Section 124.203 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS PROCEDURES FOR DECISIONMAKING Procedures for RCRA Standardized Permit Applying for A Standardized Permit § 124.203 How may I switch from my individual RCRA permit to...

  13. Fnr (EtrA) acts as a fine-tuning regulator of anaerobic metabolism in Shewanella oneidensis MR-1

    SciTech Connect

    Cruz-Garza, Claribel; Murray, Alison E.; Rodrigues, Jorge L.M.; Gralnick, Jeffrey A.; McCue, Lee Ann; Romine, Margaret F.; Loffler, F. E.; Tiedje, James M.

    2011-03-30

    EtrA in Shewanella oneidensis MR-1, a model organism for study of adaptation to varied redox niches, shares 73.6% and 50.8% amino acid sequence identity with the oxygen-sensing regulators Fnr in E. coli and Anr in Pseudomonas aeruginosa, respectively; however, its regulatory role of anaerobic metabolism in Shewanella spp. is not well understood. The expression of the nap genes, nrfA, cymA and hcp was significantly reduced in etrA deletion mutant EtrA7-1; however, limited anaerobic growth and nitrate reduction occurred, suggesting that multiple regulators control nitrate reduction in this strain. Dimethyl sulfoxide (DMSO) and fumarate reductase gene expression was down regulated at least 2-fold and the EtrA7-1 mutant grew poorly with fumarate and dimethyl sulfoxide (DMSO), suggesting both respiratory pathways are under EtrA control. Transcript analysis further suggested a role of EtrA in prophage activation and down regulation of genes implicated in aerobic metabolism. In contrast to previous studies that attributed a minor regulatory role to EtrA in Shewanella spp., this study demonstrates that EtrA acts as a global transcriptional regulator and confers physiological advantages to strain MR-1 under certain growth conditions. In conjunction with other regulators, EtrA fine-tunes the expression of genes involved in anaerobic metabolism in S. oneidensis strain MR-1.

  14. Proposed modifications to the RCRA post-closure permit for the Bear Creek Hydrogeologic Regime at the US Department of Energy Y-12 Plant, Oak Ridge, Tennessee

    SciTech Connect

    1997-05-01

    This report presents proposed modifications to several conditions of the Resource Conservation and Recovery Act (RCRA) Post-Closure Permit (PCP) for the Bear Creek Hydrogeologic Regime (BCHR). These permit conditions define the requirements for RCRA post-closure corrective action groundwater monitoring at the S-3 Ponds, the Oil Landfarm, and the Bear Creek Burial Grounds (units A, C-West, and Walk-in Pits). Modification of these PCP conditions is requested to: (1) clarify the planned integration of RCRA post-closure corrective action groundwater monitoring with the monitoring program to be established in the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) Record of Decision (ROD) for the Bear Creek Valley (BCV) Watershed, (2) revise several of the current technical requirements for groundwater monitoring based on implementation of the RCRA post-closure corrective action monitoring program during 1996, and (3) update applicable technical procedures with revised versions recently issued by the Y-12 Plant Groundwater Protection Program (GWPP). With these modifications, the Y-12 Plant will continue to meet the full intent of all regulatory obligations for post-closure care of these facilities. Section 2.0 provides the technical justification for each proposed permit modification. The proposed changes to permit language are provided in Section 3.0 (S-3 Ponds), Section 4.0 (Oil Landfarm), and Section 5.0 (Bear Creek Burial Grounds). Sections 6.0 and 7.0 reference updated and revised procedures for groundwater sampling, and monitoring well plugging and abandonment, respectively. Appendix A includes all proposed revisions to the PCP Attachments.

  15. 78 FR 36693 - Rules and Regulations Under the Fur Products Labeling Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-19

    ... guaranties annually. \\10\\ 78 FR 29263 (May 20, 2013). In light of the proposed amendments to the Textile... Act, 77 FR 57043 (Sept. 17, 2012). \\8\\ National Retail Federation Comment 00025 at 1-5, available at... Activities; Submission for OMB Review; Comment Request, 7 FR 10744 (Feb. 23, 2012). D. Projected...

  16. 20 CFR 626.4 - Table of contents for the Job Training Partnership Act regulations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ....805Security and law enforcement. 638.806Property management and procurement. 638.807Imprest and petty cash... the Job Training Partnership Act, 20 CFR parts 626-638 and 1005, 1 is as follows: 1 Part 1005 was...-risk” recipients and subrecipients. 627.424Prohibition of subawards to debarred and suspended...

  17. 77 FR 43782 - Acquisition Regulations; Buy Indian Act; Procedures for Contracting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-26

    ... Planning and Review (Executive Order 12866) B. Regulatory Flexibility Act C. Small Business Regulatory... to set aside procurement contracts for Indian-owned and controlled businesses. This rule supplements... ownership of business enterprises from a mandatory 100 percent to minimum 51 percent. In addition,...

  18. 76 FR 63817 - Disclosure of Information; Privacy Act Regulations; Notice and Amendments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-14

    ... supervisory agency, for purposes of Sec. 309.6, to which exempt records could be disclosed.\\1\\ \\1\\ 76 FR 35963.... D. Plain Language Section 722 of the Gramm-Leach-Bliley Act (Pub. L. 106-102, 113 Stat. 1338, 1471), requires the Federal banking agencies to use plain language in all proposed and final rules published...

  19. 77 FR 23196 - Native American Graves Protection and Repatriation Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-18

    ... Office of the Secretary 43 CFR Part 10 RIN 1024-AD99 Native American Graves Protection and Repatriation... Secretary of the Interior (Secretary) is responsible for implementation of the Native American Graves... implementing the Native American ] Graves Protection and Repatriation Act for purposes of factual accuracy...

  20. Trans-acting factors regulate the expression of CD44 splice variants.

    PubMed Central

    Konig, H; Moll, J; Ponta, H; Herrlich, P

    1996-01-01

    Variant isoforms of the cell surface glycoprotein CD44 (CD44v) are expressed during development, in selected adult tissues and in certain metastatic tumor cells. CD44v differ from the standard isoform (CD44s) by up to ten additional exon sequences included by alternative splicing. By cell fusion experiments, we have obtained evidence for the existence of cell-type specific trans-acting factors recruiting CD44 variant exon sequences. Stable cell hybrids of CD44s and CD44v expressing cells indicated a dominant mechanism for variant-exon inclusion. In transient interspecies heterokaryons of human keratinocytes and rat fibroblasts, the ability of the keratinocytes to include all variant exon sequences in CD44 was conferred completely on the rat fibroblast nucleus. Fusions of cells with complex CD44 splice patterns do not permit interpretation of splice control by the relative abundance of a single trans-acting factor, but rather by (a) positively acting factor(s) recruiting variant exon sequences in the 3' to 5' direction and additional factors selecting individual exons. Since the pancreatic carcinoma cell line BSp73ASML (in contrast to the cervix carcinoma cell lines SiHa and ME180) could not transfer its specific splice pattern in cell fusions, we conclude that in some tumors, splicing is also controlled by mutation of cis-acting recognition sites. Images PMID:8670907

  1. 77 FR 74546 - Posting of Pamphlet Provided for in the International Marriage Broker Regulation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-14

    ... Act, Title D of Public Law 109-162, provided that the Secretary of Homeland Security, in consultation... such pamphlet be posted on the Web sites of the Department of State and all consular posts processing applications for K (fianc (e) or spouse of U.S. citizen) visas. This notice announces that this pamphlet...

  2. 77 FR 29982 - Federal Acquisition Regulation; Submission for OMB Review; Davis Bacon Act-Price Adjustment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ...: A. Purpose Government contracting officers may include FAR clause 52.222-32, Davis-Bacon Act--Price... may reasonably require. The information is used by ] Government contracting officers to establish the... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF...

  3. 75 FR 63425 - Regulations Implementing the Longshore and Harbor Workers' Compensation Act: Recreational Vessels

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-15

    ... and Harbor Workers' Compensation Act: Recreational Vessels, published on August 17, 2010 (75 FR 50718... comments. 75 FR 50718 (Aug. 17, 2010). As explained in the supplementary information section below, the..., 2009 (see Secretary's Order 10-2009, 74 FR 58834 (Nov. 13, 2009)), that title was no longer...

  4. The Strong Expression and Conserved Regulation of ACT2 in Arabidopsis and Physcomitrella Patens

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Actin genes encode structurally and functionally conserved proteins essential in a variety of cellular functions across eukaryotic species. In this report, we demonstrated that regulatory activity of ACT2 5’ regulatory region was significantly higher than that of the CaMV 35S promoter in Arabidopsis...

  5. Market effects of environmental regulation: coal, railroads, and the 1990 Clean Air Act

    SciTech Connect

    Busse, M.R.; Keohane, N.O.

    2007-01-01

    Many environmental regulations encourage the use of 'clean' inputs. When the suppliers of such an input have market power, environmental regulation will affect not only the quantity of the input used but also its price. We investigate the effect of the Title IV emissions trading program for sulfur dioxide on the market for low-sulfur coal. We find that the two railroads transporting coal were able to price discriminate on the basis of environmental regulation and geographic location. Delivered prices rose for plants in the trading program relative to other plants, and by more at plants near a low-sulfur coal source.

  6. The munitions provisions of the Federal Facility Compliance Act

    SciTech Connect

    Kimmell, T.A.; Green, D.R.; Queen, R.

    1994-03-01

    The Federal Facility Compliance Act (FFCA) was signed by President Bush on October 6, 1992. This Act amends the Resource Conservation and Recovery Act (RCRA), the primary law governing hazardous waste management in the US The most significant provision of the FFCA was the waiver of sovereign immunity. This waiver subjects Federal facilities to the same ``incentives`` as the private sector for compliance. While the waiver has broad implications for all Federal facilities, other provisions of the FFCA impact specific sectors of the Federal complex. The focus of this paper is the FFCA Munitions Provisions, which have the potential to change some aspects of the structure of munitions management within the military. The Munitions Provisions, contained in Section 107 of the FFCA, modifies Section 3004 of RCRA by adding a new subsection (y) on Munitions. Section 107 requires the Environmental Protection Agency (EPA) to develop, after consultation with the Department of Defense (DOD) and appropriate State officials, regulations identifying when military munitions (including conventional and chemical munitions) become hazardous waste, and to provide for the safe transportation and storage of such waste. The FFCA requires EPA to promulgate the final ``Munitions Rule`` by October 6, 1994. These are the only provisions of the FFCA that require a new rulemaking. It is clear that the Munitions Rule could have a significant effect on the way in which DOD manages munitions. Demilitarization, range management, training activities, and emergency response actions may be affected. It is important for DOD, the Services, and individual installations, to be aware of potential impacts of the FFCA on munitions management operations. The purpose of this paper is to review several important munitions Rule issues, and to discuss potential impacts of these issues.

  7. 75 FR 66699 - Lacey Act Implementation Plan; Definitions for Exempt and Regulated Articles

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-29

    ... published in the Federal Register (75 FR 46859-46861, Docket No. APHIS-2009-0018) a proposal to establish... Implementation Plan; Definitions for Exempt and Regulated Articles AGENCY: Animal and Plant Health...

  8. 75 FR 3665 - Regulations under the Comprehensive Smokeless Tobacco Health Education Act; Termination of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-22

    ... cars, banners, flags, and other event-related objects. On November 4, 1993 (58 FR 58810), the FTC... Tobacco to Protect Children and Adolescents, 61 FR 44615-618 (Aug. 28, 1996). Those regulations...

  9. Ethylene acts as a negative regulator of glucose induced lateral root emergence in Arabidopsis.

    PubMed

    Singh, Manjul; Gupta, Aditi; Laxmi, Ashverya

    2015-01-01

    Plants, being sessile organisms, are more exposed to the hazards of constantly changing environmental conditions globally. During the lifetime of a plant, the root system encounters various challenges such as obstacles, pathogens, high salinity, water logging, nutrient scarcity etc. The developmental plasticity of the root system provides brilliant adaptability to plants to counter the changes exerted by both external as well as internal cues and achieve an optimized growth status. Phytohormones are one of the major intrinsic factors regulating all aspects of plant growth and development both independently as well as through complex signal integrations at multiple levels. We have previously shown that glucose (Glc) and brassinosteroid (BR) signalings interact extensively to regulate lateral root (LR) development in Arabidopsis. (1) Auxin efflux as well as influx and downstream signaling components are also involved in Glc-BR regulation of LR emergence. Here, we provide evidence for involvement of ethylene signaling machinery downstream to Glc and BR in regulation of LR emergence. PMID:26236960

  10. Solid waste landfills under the Resource Conservation and Recovery Act Subtitle D

    SciTech Connect

    1995-11-01

    This document provides guidance for meeting: (1) Guidelines for the Land Disposal of Solid Waste (40 CFR 241); (2) Criteria for Classification of Solid Waste Disposal Facilities and Practices (40 CFR 257); and (3) Criteria for Municipal Solid Waste Landfills (MSWLFs) (40 CFR Part 258). Revisions to 40 CFR 257 and a new Part 258 were published in the Federal Register (56 FR 50978, 10/9/91). The Guidelines for the Land Disposal of Solid Waste set requirements and recommended procedures to ensure that the design, construction, and operation of land disposal sites is done in a manner that will protect human health and the environment. These regulations are applicable to MSWLFs and non-MSWLFs (e.g., landfills used only for the disposal of demolition debris, commercial waste, and/or industrial waste). These guidelines are not applicable to the, land disposal of hazardous, agricultural, and/or mining wastes. These criteria are to be used under the Resource Conservation and Recovery Act (RCRA) in determining which solid waste disposal facilities pose a reasonable possibility of adversely affecting human health or the environment. Facilities failing to satisfy these criteria will be considered to be open dumps which are prohibited under Section 4005 of RCRA. The Criteria for MSWLFs are applicable only to MSWLFs, including those MSWLFs in which sewage sludge is co-disposed with household waste. Based on specific criteria, certain MSWLFs are exempt from some, or all, of the regulations of 40 CFR 258. MSWLFs that fail to satisfy the criteria specified in 40 CFR 258 are also considered open dumps for the purposes of Section 4005 of RCRA. Through the use of a series of interrelated flow diagrams, this guidance document directs the reader to each design, operation, maintenance, and closure activity that must be performed for MSWLFs and non-MSWLFs.

  11. Methyl-CpG binding domain protein acts to regulate the repair of cyclobutane pyrimidine dimers on rice DNA

    PubMed Central

    Fang, Changxun; Chen, Weisi; Li, Chengxun; Jian, Xin; Li, Yingzhe; Lin, Hongmei; Lin, Wenxiong

    2016-01-01

    UVB radiation causes cyclobutane pyrimidine dimers (CPDs) to form on the DNA of living organisms. This study found that overexpression of the silicon absorbance gene Lsi1 reduced the accumulation of CPDs in rice, which profited from the reactivation by photolyase. The transcript abundance of deoxyribodipyrimidine photolyase (Os10g0167600) was generally correlated with the silicon content of the rice, and the up-regulation of Os10g0167600 was found to be highest in the UVB-treated Lsi1-overexpressed (Lsi1-OX) rice. A trans-acting factor, methyl-CpG binding domain protein (OsMeCP), was found to interact with the cis-element of Os10g0167600. The nucleic location of OsMeCP effectively enabled the transcriptional regulation. Compared with the WT, the level of OsMeCP was lower in the Lsi1-OX rice but higher in the Lsi1-RNAi line. Rice cultured in a high silicate-concentration solution also exhibited less OsMeCP abundance. Overexpression of OsMeCP led to lower Os10g0167600 transcript levels and a higher CPD content than in the WT, but the reverse was true in the OsMeCP-RNAi line. These findings indicate that OsMeCP acts as a negative regulator of silicon, and can mediate the repression of the transcription from Os10g0167600, which inhibits the photoreactivation of the photolyase involved in the repair of CPDs. PMID:27694845

  12. The transcription factor TFEB acts as a molecular switch that regulates exogenous antigen-presentation pathways.

    PubMed

    Samie, Mohammad; Cresswell, Peter

    2015-07-01

    Dendritic cells (DCs) can initiate immune responses by presenting exogenous antigens to T cells via both major histocompatibility complex (MHC) class I pathways and MHC class II pathways. Lysosomal activity has an important role in modulating the balance between these two pathways. The transcription factor TFEB regulates lysosomal function by inducing lysosomal activation. Here we report that TFEB expression inhibited the presentation of exogenous antigen by MHC class I while enhancing presentation via MHC class II. TFEB promoted phagosomal acidification and protein degradation. Furthermore, we found that the activation of TFEB was regulated during DC maturation and that phagosomal acidification was impaired in DCs in which the gene encoding TFEB was silenced. Our data indicate that TFEB is a key participant in the differential regulation of the presentation of exogenous antigens by DCs.

  13. Nitric Oxide Acts as a Positive Regulator to Induce Metamorphosis of the Ascidian Herdmania momus

    PubMed Central

    Ueda, Nobuo; Degnan, Sandie M.

    2013-01-01

    Marine invertebrates commonly have a biphasic life cycle in which the metamorphic transition from a pelagic larva to a benthic post-larva is mediated by the nitric oxide signalling pathway. Nitric oxide (NO) is synthesised by nitric oxide synthase (NOS), which is a client protein of the molecular chaperon heat shock protein 90 (HSP90). It is notable, then, that both NO and HSP90 have been implicated in regulating metamorphosis in marine invertebrates as diverse as urochordates, echinoderms, molluscs, annelids, and crustaceans. Specifically, the suppression of NOS activity by the application of either NOS- or HSP90-inhibiting pharmacological agents has been shown consistently to induce the initiation of metamorphosis, leading to the hypothesis that a negative regulatory role of NO is widely conserved in biphasic life cycles. Further, the induction of metamorphosis by heat-shock has been demonstrated for multiple species. Here, we investigate the regulatory role of NO in induction of metamorphosis of the solitary tropical ascidian, Herdmania momus. By coupling pharmacological treatments with analysis of HmNOS and HmHSP90 gene expression, we present compelling evidence of a positive regulatory role for NO in metamorphosis of this species, in contrast to all existing ascidian data that supports the hypothesis of NO as a conserved negative regulator of metamorphosis. The exposure of competent H. momus larvae to a NOS inhibitor or an NO donor results in an up-regulation of NOS and HSP90 genes. Heat shock of competent larvae induces metamorphosis in a temperature dependent manner, up to a thermal tolerance that approaches 35°C. Both larval/post-larval survival and the appearance of abnormal morphologies in H. momus post-larvae reflect the magnitude of up-regulation of the HSP90 gene in response to heat-shock. The demonstrated role of NO as a positive metamorphic regulator in H. momus suggests the existence of inter-specific adaptations of NO regulation in ascidian

  14. Nitric oxide acts as a positive regulator to induce metamorphosis of the ascidian Herdmania momus.

    PubMed

    Ueda, Nobuo; Degnan, Sandie M

    2013-01-01

    Marine invertebrates commonly have a biphasic life cycle in which the metamorphic transition from a pelagic larva to a benthic post-larva is mediated by the nitric oxide signalling pathway. Nitric oxide (NO) is synthesised by nitric oxide synthase (NOS), which is a client protein of the molecular chaperon heat shock protein 90 (HSP90). It is notable, then, that both NO and HSP90 have been implicated in regulating metamorphosis in marine invertebrates as diverse as urochordates, echinoderms, molluscs, annelids, and crustaceans. Specifically, the suppression of NOS activity by the application of either NOS- or HSP90-inhibiting pharmacological agents has been shown consistently to induce the initiation of metamorphosis, leading to the hypothesis that a negative regulatory role of NO is widely conserved in biphasic life cycles. Further, the induction of metamorphosis by heat-shock has been demonstrated for multiple species. Here, we investigate the regulatory role of NO in induction of metamorphosis of the solitary tropical ascidian, Herdmania momus. By coupling pharmacological treatments with analysis of HmNOS and HmHSP90 gene expression, we present compelling evidence of a positive regulatory role for NO in metamorphosis of this species, in contrast to all existing ascidian data that supports the hypothesis of NO as a conserved negative regulator of metamorphosis. The exposure of competent H. momus larvae to a NOS inhibitor or an NO donor results in an up-regulation of NOS and HSP90 genes. Heat shock of competent larvae induces metamorphosis in a temperature dependent manner, up to a thermal tolerance that approaches 35°C. Both larval/post-larval survival and the appearance of abnormal morphologies in H. momus post-larvae reflect the magnitude of up-regulation of the HSP90 gene in response to heat-shock. The demonstrated role of NO as a positive metamorphic regulator in H. momus suggests the existence of inter-specific adaptations of NO regulation in ascidian

  15. Technology diffusion and environmental regulation: Evidence from electric power plants under the Clean Air Act

    NASA Astrophysics Data System (ADS)

    Frey, Elaine F.

    Even though environmental policy can greatly affect the path of technology diffusion, the economics literature contains limited empirical evidence of this relationship. My research will contribute to the available evidence by providing insight into the technology adoption decisions of electric generating firms. Since policies are often evaluated based on the incentives they provide to promote adoption of new technologies, it is important that policy makers understand the relationship between technological diffusion and regulation structure to make informed decisions. Lessons learned from this study can be used to guide future policies such as those directed to mitigate climate change. I first explore the diffusion of scrubbers, a sulfur dioxide (SO 2) abatement technology, in response to federal market-based regulations and state command-and-control regulations. I develop a simple theoretical model to describe the adoption decisions of scrubbers and use a survival model to empirically test the theoretical model. I find that power plants with strict command-and-control regulations have a high probability of installing a scrubber. These findings suggest that although market-based regulations have encouraged diffusion, many scrubbers have been installed because of state regulatory pressure. Although tradable permit systems are thought to give firms more flexibility in choosing abatement technologies, I show that interactions between a permit system and pre-existing command-and-control regulations can limit that flexibility. In a separate analysis, I explore the diffusion of combined cycle (CC) generating units, which are natural gas-fired generating units that are cleaner and more efficient than alternative generating units. I model the decision to consider adoption of a CC generating unit and the extent to which the technology is adopted in response to environmental regulations imposed on new sources of pollutants. To accomplish this, I use a zero-inflated Poisson

  16. RCRA corrective measures using a permeable reactive iron wall US Coast Guard Support Center, Elizabeth City, North Carolina

    SciTech Connect

    Schmithors, W.L.; Vardy, J.A.

    1997-12-31

    A chromic acid release was discovered at a former electroplating shop at the U.S. Coast Guard Support Center in Elizabeth City, North Carolina. Initial investigative activities indicated that chromic acid had migrated into the subsurface soils and groundwater. In addition, trichloroethylene (TCE) was also discovered in groundwater during subsequent investigations of the hexavalent chromium (Cr VI) plume. Corrective measures were required under the Resource Conservation and Recovery Act (RCRA). The in-situ remediation method, proposed under RCRA Interim Measures to passively treat the groundwater contaminants, uses reactive zero-valent iron to reductively dechlorinate the chlorinated compounds and to mineralize the hexavalent chromium. A 47 meter by 0.6 meter subsurface permeable iron wall was installed downgradient of the source area to a depth of 7 meters using a direct trenching machine. The iron filings were placed in the ground as the soils were excavated from the subsurface. This is the first time that direct trenching was used to install reactive zero-valent iron filings. Over 250 metric tons of iron filings were used as the reactive material in the barrier wall. Installation of the iron filings took one full day. Extensive negotiations with regulatory agencies were required to use this technology under the current facility Hazardous Waste Management Permit. All waste soils generated during the excavation activities were contained and treated on site. Once contaminant concentrations were reduced the waste soils were used as fill material.

  17. Regulations for the administration and enforcement of the Radiation Control for Health and Safety Act of 1968

    SciTech Connect

    Not Available

    1988-04-01

    The purpose of the Act is to protect the public from unnecessary exposure to radiation from electronic products, including ionizing, nonionizing, electromagnetic, or particulate radiation, or any sonic, infrasonic, or ultrasonic wave. The regulations in the publication cover general provisions, statements of policy and interpretation, radiation protection recommendations, recordkeeping and reporting requirements for manufacturers, dealers, and distributors; notification requirements for defects or failure to comply; repurchase, repairs, or replacement of electronic products; importation of products; and performance standards for television receivers, cathode ray tubes, diagnostic x-ray equipment, radiographic equipment, fluoroscopic equipment, computer aided tomography equipment, microwave ovens, laser products, sunlamps, ultraviolet lamps, mercury lamps, and ultrasonic therapy products.

  18. 77 FR 19455 - Regulations Implementing the Byrd Amendments to the Black Lung Benefits Act: Determining Coal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-30

    ... 65 FR 79920, 80029 (Dec. 20, 2000); 20 CFR 725.4(d) (2011). Consequently, there is no reason to..., 20 CFR 718.2 (2011); 45 FR 13677, 13679 (Feb. 29, 1980). The proposed rule does, however, retain... Federal Regulations in 2000. See 65 FR 79920, 80029 (Dec. 20, 2000); 20 CFR 725.4(d) (2011)....

  19. 75 FR 68911 - Regulations Under the Genetic Information Nondiscrimination Act of 2008

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-09

    ... document. See 74 FR 9056 (March 2, 2009). Several days earlier, on February 25, 2009, the Commission held a... FR 51664. The HHS Office for Civil Rights is responsible for issuing the regulations applicable to GINA section 105 and issued a proposed rule on October 7, 2009 at 74 FR 51698. Among the various...

  20. 78 FR 60686 - Regulations Implementing the Byrd Amendments to the Black Lung Benefits Act: Determining Coal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ..., 2013 (78 FR 59102). The preamble incorrectly stated that the Office of Information and Regulatory... of Workers' Compensation Programs 20 CFR Parts 718 and 725 RIN 1240-AA04 Regulations Implementing the... Benefits; Correction AGENCY: Office of Workers' Compensation Programs, Labor. ACTION: Final...

  1. 78 FR 59101 - Regulations Implementing the Byrd Amendments to the Black Lung Benefits Act: Determining Coal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-25

    ... public comment. 77 FR 19456-19478 (Mar. 30, 2012). These amendments reinstated two BLBA entitlement... Department recounted the history of these provisions in the NPRM. 77 FR at 19456-58. The Department also... streamlining the regulations where possible. See generally Executive Order 13563, 76 FR 3821 (January 18,...

  2. ISOCAM observations of the RCrA star formation region

    NASA Astrophysics Data System (ADS)

    Olofsson, G.; Huldtgren, M.; Kaas, A. A.; Bontemps, S.; Nordh, L.; Abergel, A.; André, P.; Boulanger, F.; Burgdorf, M.; Casali, M. M.; Cesarsky, C. J.; Davies, J.; Falgarone, E.; Montmerle, T.; Perault, M.; Persi, P.; Prusti, T.; Puget, J. L.; Sibille, F.

    1999-10-01

    The results of an ISOCAM survey of the RCrA star formation region are presented. The survey was carried out in two broad-band filters, LW2 (5-8.5 mu m) and LW3 (12-18 mu m). Although it was not possible to map the densest, central region due to saturation problems, 21 sources were identified which showed mid-IR excesses. Most of these sources have not previously been recognised as YSOs (Young Stellar Objects), mainly because they are relatively faint. We find evidence for a population of very low mass stars which are probably brown dwarfs in their early contraction phases. ISO is an ESA project with instruments funded by ESA Member States (especially the PI countries: France, Germany, the Netherlands and the United Kingdom) and with the participation of ISAS and NASA.

  3. GIGANTEA acts in blue light signaling and has biochemically separable roles in circadian clock and flowering time regulation.

    PubMed

    Martin-Tryon, Ellen L; Kreps, Joel A; Harmer, Stacey L

    2007-01-01

    Circadian clocks are widespread in nature. In higher plants, they confer a selective advantage, providing information regarding not only time of day but also time of year. Forward genetic screens in Arabidopsis (Arabidopsis thaliana) have led to the identification of many clock components, but the functions of most of these genes remain obscure. To identify both new constituents of the circadian clock and new alleles of known clock-associated genes, we performed a mutant screen. Using a clock-regulated luciferase reporter, we isolated new alleles of ZEITLUPE, LATE ELONGATED HYPOCOTYL, and GIGANTEA (GI). GI has previously been reported to function in red light signaling, central clock function, and flowering time regulation. Characterization of this and other GI alleles has helped us to further define GI function in the circadian system. We found that GI acts in photomorphogenic and circadian blue light signaling pathways and is differentially required for clock function in constant red versus blue light. Gene expression and epistasis analyses show that TIMING OF CHLOROPHYLL A/B BINDING PROTEIN1 (TOC1) expression is not solely dependent upon GI and that GI expression is only indirectly affected by TOC1, suggesting that GI acts both in series with and in parallel to TOC1 within the central circadian oscillator. Finally, we found that the GI-dependent promotion of CONSTANS expression and flowering is intact in a gi mutant with altered circadian regulation. Thus GI function in the regulation of a clock output can be biochemically separated from its role within the circadian clock.

  4. Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription.

    PubMed Central

    Comb, M; Mermod, N; Hyman, S E; Pearlberg, J; Ross, M E; Goodman, H M

    1988-01-01

    Synthesis of the endogenous opioid precursor, proenkephalin, is regulated by neurotransmitters and membrane depolarization. These events act through second messenger dependent signal transduction pathways via a short inducible DNA enhancer to regulate transcription of the proenkephalin gene. Two DNA elements located within this enhancer are essential for the transcriptional response to cAMP and phorbol ester. Inactivation of either element by mutation or by alteration of their stereospecific alignment eliminates inducible enhancer activity. The promoter distal element, ENKCRE-1, in the absence of a functional adjacent ENKCRE-2 element, has no inherent capacity to activate transcription. However, in the presence of a functional ENKCRE-2 element, this element synergistically augments cAMP and phorbol ester inducible transcription. The promoter proximal element, ENKCRE-2, is essential for both basal and regulated enhancer function. Four different protein factors found in HeLa cell nuclear extracts bind in vitro to the enhancer region. ENKTF-1, a novel enhancer binding protein, binds to the DNA region encompassing ENKCRE-1. The transcription factors AP-1 and AP-4 bind to overlapping sites spanning ENKCRE-2, and a fourth transcription factor, AP-2, binds to a site immediately downstream of ENKCRE-2. The binding of ENKTF-1 to mutant ENKCRE-1 sequences in vitro correlates with the in vivo inducibility of the mutant elements suggesting that ENKTF-1 acts in combination with factors that recognize the ENKCRE-2 domain to regulate cAMP inducible transcription. Together, the two DNA elements, ENKCRE-1 and ENKCRE-2 and the protein factors with which they interact, play a critical role in the transduction and reception of signals transmitted from cell surface receptors to the proenkephalin nuclear transcription complex. Images PMID:2850173

  5. Strigolactone acts downstream of auxin to regulate bud outgrowth in pea and Arabidopsis.

    PubMed

    Brewer, Philip B; Dun, Elizabeth A; Ferguson, Brett J; Rameau, Catherine; Beveridge, Christine A

    2009-05-01

    During the last century, two key hypotheses have been proposed to explain apical dominance in plants: auxin promotes the production of a second messenger that moves up into buds to repress their outgrowth, and auxin saturation in the stem inhibits auxin transport from buds, thereby inhibiting bud outgrowth. The recent discovery of strigolactone as the novel shoot-branching inhibitor allowed us to test its mode of action in relation to these hypotheses. We found that exogenously applied strigolactone inhibited bud outgrowth in pea (Pisum sativum) even when auxin was depleted after decapitation. We also found that strigolactone application reduced branching in Arabidopsis (Arabidopsis thaliana) auxin response mutants, suggesting that auxin may act through strigolactones to facilitate apical dominance. Moreover, strigolactone application to tiny buds of mutant or decapitated pea plants rapidly stopped outgrowth, in contrast to applying N-1-naphthylphthalamic acid (NPA), an auxin transport inhibitor, which significantly slowed growth only after several days. Whereas strigolactone or NPA applied to growing buds reduced bud length, only NPA blocked auxin transport in the bud. Wild-type and strigolactone biosynthesis mutant pea and Arabidopsis shoots were capable of instantly transporting additional amounts of auxin in excess of endogenous levels, contrary to predictions of auxin transport models. These data suggest that strigolactone does not act primarily by affecting auxin transport from buds. Rather, the primary repressor of bud outgrowth appears to be the auxin-dependent production of strigolactones. PMID:19321710

  6. Potential Impact of Clean Air Act Regulations on Nitrogen Fate and Transport in the Neuse River Basin: a Modeling Investigation Using CMAQ and SWAT

    EPA Science Inventory

    There has been extensive analysis of Clean Air Act Amendment (CAAA) regulation impacts to changes in atmospheric nitrogen deposition; however, few studies have focused on watershed nitrogen transfer particularly regarding long-term predictions. In this study, we investigated impa...

  7. Thyroid Hormone May Regulate mRNA Abundance in Liver by Acting on MicroRNAs

    PubMed Central

    Dong, Hongyan; Paquette, Martin; Williams, Andrew; Zoeller, R. Thomas; Wade, Mike; Yauk, Carole

    2010-01-01

    MicroRNAs (miRNAs) are extensively involved in diverse biological processes. However, very little is known about the role of miRNAs in mediating the action of thyroid hormones (TH). Appropriate TH levels are known to be critically important for development, differentiation and maintenance of metabolic balance in mammals. We induced transient hypothyroidism in juvenile mice by short-term exposure to methimazole and perchlorate from post natal day (PND) 12 to 15. The expression of miRNAs in the liver was analyzed using Taqman Low Density Arrays (containing up to 600 rodent miRNAs). We found the expression of 40 miRNAs was significantly altered in the livers of hypothyroid mice compared to euthyroid controls. Among the miRNAs, miRs-1, 206, 133a and 133b exhibited a massive increase in expression (50- to 500-fold). The regulation of TH on the expression of miRs-1, 206, 133a and 133b was confirmed in various mouse models including: chronic hypothyroid, short-term hyperthyroid and short-term hypothyroid followed by TH supplementation. TH regulation of these miRNAs was also confirmed in mouse hepatocyte AML 12 cells. The expression of precursors of miRs-1, 206, 133a and 133b were examined in AML 12 cells and shown to decrease after TH treatment, only pre-mir-206 and pre-mir-133b reached statistical significance. To identify the targets of these miRNAs, DNA microarrays were used to examine hepatic mRNA levels in the short-term hypothyroid mouse model relative to controls. We found transcripts from 92 known genes were significantly altered in these hypothyroid mice. Web-based target predication software (TargetScan and Microcosm) identified 14 of these transcripts as targets of miRs-1, 206, 133a and 133b. The vast majority of these mRNA targets were significantly down-regulated in hypothyroid mice, corresponding with the up-regulation of miRs-1, 206, 133a and 133b in hypothyroid mouse liver. To further investigate target genes, miR-206 was over-expressed in AML 12 cells. TH

  8. Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance

    PubMed Central

    Tsang, Chi Kwan; Liu, Yuan; Thomas, Janice; Zhang, Yanjie; Zheng, X. F. Steven

    2015-01-01

    Summary Superoxide dismutase 1 (Sod1) has been known for nearly half a century for catalysis of superoxide to hydrogen peroxide. Here we report a new Sod1 function in oxidative signaling: in response to elevated endogenous and exogenous reactive oxygen species (ROS), Sod1 rapidly relocates into the nucleus, which is important for maintaining genomic stability. Interestingly, H2O2 is sufficient to promote Sod1 nuclear localization, indicating that it is responding to general ROS rather than Sod1 substrate superoxide. ROS signaling is mediated by Mec1/ATM and its effector Dun1/Cds1 kinase, through Dun1 interaction with Sod1 and regulation of Sod1 by phosphorylation at S60, 99. In the nucleus, Sod1 binds to the promoters and regulates the expression of oxidative resistance and repair genes. Altogether, our study unravels an unorthodox function of Sod1 as a transcription factor and elucidates the regulatory mechanism for its localization. PMID:24647101

  9. Anaplastic Lymphoma Kinase Acts in the Drosophila Mushroom Body to Negatively Regulate Sleep.

    PubMed

    Bai, Lei; Sehgal, Amita

    2015-11-01

    Though evidence is mounting that a major function of sleep is to maintain brain plasticity and consolidate memory, little is known about the molecular pathways by which learning and sleep processes intercept. Anaplastic lymphoma kinase (Alk), the gene encoding a tyrosine receptor kinase whose inadvertent activation is the cause of many cancers, is implicated in synapse formation and cognitive functions. In particular, Alk genetically interacts with Neurofibromatosis 1 (Nf1) to regulate growth and associative learning in flies. We show that Alk mutants have increased sleep. Using a targeted RNAi screen we localized the negative effects of Alk on sleep to the mushroom body, a structure important for both sleep and memory. We also report that mutations in Nf1 produce a sexually dimorphic short sleep phenotype, and suppress the long sleep phenotype of Alk. Thus Alk and Nf1 interact in both learning and sleep regulation, highlighting a common pathway in these two processes. PMID:26536237

  10. Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis

    PubMed Central

    Li, Haisen; Yue, Rui; Wei, Bin; Gao, Ge; Du, Jiulin; Pei, Gang

    2014-01-01

    Primitive hematopoiesis occurs in the yolk sac blood islands during vertebrate embryogenesis, where abundant phosphatidylcholines (PC) are available as important nutrients for the developing embryo. However, whether these phospholipids also generate developmental cues to promote hematopoiesis is largely unknown. Here, we show that lysophosphatidic acid (LPA), a signaling molecule derived from PC, regulated hemangioblast formation and primitive hematopoiesis. Pharmacological and genetic blockage of LPA receptor 1 (LPAR1) or autotoxin (ATX), a secretory lysophospholipase that catalyzes LPA production, inhibited hematopoietic differentiation of mouse embryonic stem cells and impaired the formation of hemangioblasts. Mechanistic experiments revealed that the regulatory effect of ATX-LPA signaling was mediated by PI3K/Akt-Smad pathway. Furthermore, during in vivo embryogenesis in zebrafish, LPA functioned as a developmental cue for hemangioblast formation and primitive hematopoiesis. Taken together, we identified LPA as an important nutrient-derived developmental cue for primitive hematopoiesis as well as a novel mechanism of hemangioblast regulation. PMID:24829209

  11. Cux2 acts as a critical regulator for neurogenesis in the olfactory epithelium of vertebrates.

    PubMed

    Wittmann, Walter; Iulianella, Angelo; Gunhaga, Lena

    2014-04-01

    Signaling pathways and transcription factors are crucial regulators of vertebrate neurogenesis, exerting their function in a spatial and temporal manner. Despite recent advances in our understanding of the molecular regulation of embryonic neurogenesis, little is known regarding how different signaling pathways interact to tightly regulate this process during the development of neuroepithelia. To address this, we have investigated the events lying upstream and downstream of a key neurogenic factor, the Cut-like homeodomain transcription factor-2 (Cux2), during embryonic neurogenesis in chick and mouse. By using the olfactory epithelium as a model for neurogenesis we have analyzed mouse embryos deficient in Cux2, as well as chick embryos exposed to Cux2 silencing (si) RNA or a Cux2 over-expression construct. We provide evidence that enhanced BMP activity increases Cux2 expression and suppresses olfactory neurogenesis in the chick olfactory epithelium. In addition, our results show that up-regulation of Cux2, either BMP-induced or ectopically over-expressed, reduce Delta1 expression and suppress proliferation. Interestingly, the loss of Cux2 activity, using mutant mice or siRNA in chick, also diminishes neurogenesis, Notch activity and cell proliferation in the olfactory epithelium. Our results suggest that controlled low levels of Cux2 activity are necessary for proper Notch signaling, maintenance of the proliferative pool and ongoing neurogenesis in the olfactory epithelium. Thus, we demonstrate a novel conserved mechanism in vertebrates in which levels of Cux2 activity play an important role for ongoing neurogenesis in the olfactory epithelium.

  12. Identification of cis- and trans-acting elements regulating calretinin expression in mesothelioma cells.

    PubMed

    Kresoja-Rakic, Jelena; Kapaklikaya, Esra; Ziltener, Gabriela; Dalcher, Damian; Santoro, Raffaella; Christensen, Brock C; Johnson, Kevin C; Schwaller, Beat; Weder, Walter; Stahel, Rolf A; Felley-Bosco, Emanuela

    2016-04-19

    Calretinin (CALB2) is a diagnostic marker for epithelioid mesothelioma. It is also a prognostic marker since patients with tumors expressing high calretinin levels have better overall survival. Silencing of calretinin decreases viability of epithelioid mesothelioma cells. Our aim was to elucidate mechanisms regulating calretinin expression in mesothelioma. Analysis of calretinin transcript and protein suggested a control at the mRNA level. Treatment with 5-aza-2'-deoxycytidine and analysis of TCGA data indicated that promoter methylation is not likely to be involved. Therefore, we investigated CALB2 promoter by analyzing ~1kb of genomic sequence surrounding the transcription start site (TSS) + 1 using promoter reporter assay. Deletion analysis of CALB2 proximal promoter showed that sequence spanning the -161/+80bp region sustained transcriptional activity. Site-directed analysis identified important cis-regulatory elements within this -161/+80bp CALB2 promoter. EMSA and ChIP assays confirmed binding of NRF-1 and E2F2 to the CALB2 promoter and siRNA knockdown of NRF-1 led to decreased expression of calretinin. Cell synchronization experiment showed that calretinin expression was cell cycle regulated with a peak of expression at G1/S phase. This study provides the first insight in the regulation of CALB2 expression in mesothelioma cells.

  13. Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity

    PubMed Central

    Panayiotou, Richard; Miralles, Francesc; Pawlowski, Rafal; Diring, Jessica; Flynn, Helen R; Skehel, Mark; Treisman, Richard

    2016-01-01

    The myocardin-related transcription factors (MRTF-A and MRTF-B) regulate cytoskeletal genes through their partner transcription factor SRF. The MRTFs bind G-actin, and signal-regulated changes in cellular G-actin concentration control their nuclear accumulation. The MRTFs also undergo Rho- and ERK-dependent phosphorylation, but the function of MRTF phosphorylation, and the elements and signals involved in MRTF-A nuclear export are largely unexplored. We show that Rho-dependent MRTF-A phosphorylation reflects relief from an inhibitory function of nuclear actin. We map multiple sites of serum-induced phosphorylation, most of which are S/T-P motifs and show that S/T-P phosphorylation is required for transcriptional activation. ERK-mediated S98 phosphorylation inhibits assembly of G-actin complexes on the MRTF-A regulatory RPEL domain, promoting nuclear import. In contrast, S33 phosphorylation potentiates the activity of an autonomous Crm1-dependent N-terminal NES, which cooperates with five other NES elements to exclude MRTF-A from the nucleus. Phosphorylation thus plays positive and negative roles in the regulation of MRTF-A. DOI: http://dx.doi.org/10.7554/eLife.15460.001 PMID:27304076

  14. Identification of cis- and trans-acting elements regulating calretinin expression in mesothelioma cells

    PubMed Central

    Kresoja-Rakic, Jelena; Kapaklikaya, Esra; Ziltener, Gabriela; Dalcher, Damian; Santoro, Raffaella; Christensen, Brock C.; Johnson, Kevin C.; Schwaller, Beat; Weder, Walter; Stahel, Rolf A.; Felley-Bosco, Emanuela

    2016-01-01

    Calretinin (CALB2) is a diagnostic marker for epithelioid mesothelioma. It is also a prognostic marker since patients with tumors expressing high calretinin levels have better overall survival. Silencing of calretinin decreases viability of epithelioid mesothelioma cells. Our aim was to elucidate mechanisms regulating calretinin expression in mesothelioma. Analysis of calretinin transcript and protein suggested a control at the mRNA level. Treatment with 5-aza-2′-deoxycytidine and analysis of TCGA data indicated that promoter methylation is not likely to be involved. Therefore, we investigated CALB2 promoter by analyzing ~1kb of genomic sequence surrounding the transcription start site (TSS) + 1 using promoter reporter assay. Deletion analysis of CALB2 proximal promoter showed that sequence spanning the −161/+80bp region sustained transcriptional activity. Site-directed analysis identified important cis-regulatory elements within this −161/+80bp CALB2 promoter. EMSA and ChIP assays confirmed binding of NRF-1 and E2F2 to the CALB2 promoter and siRNA knockdown of NRF-1 led to decreased expression of calretinin. Cell synchronization experiment showed that calretinin expression was cell cycle regulated with a peak of expression at G1/S phase. This study provides the first insight in the regulation of CALB2 expression in mesothelioma cells. PMID:26848772

  15. Environmental Protection Agency--Hazardous waste and consolidated permit regulations, Parts X-XI. Final rule.

    PubMed

    1980-05-19

    This rule establishes consolidated permit program requirements governing the Hazardous Waste Management program under the Resource Conservation and Recovery Act (RCRA), the Underground Injection Control (UIC) program under the Safe Drinking Water Act (SDWA), the National Pollutant Discharge Elimination System (NPDES) program and State Dredge on Fill ("404") programs under the Clean Water Act (CWA), and the Prevention of Significant Deterioration (PSD) program under the Clean Air Act, for three primary purposes: (1) To consolidate program requirements for the RCRA and UIC programs with those already established for the NPDES program. (2) To establish requirements for State programs under the RCRA, UIC, and Section 404 programs. (3) To consolidate permit issuance procedures for EPA-issued Prevention of Significant Deterioration permits under the Clean Air Act with those for the RCRA, UIC, and NPDES programs.

  16. Environmental Protection Agency--Hazardous waste and consolidated permit regulations, Parts X-XI. Final rule.

    PubMed

    1980-05-19

    This rule establishes consolidated permit program requirements governing the Hazardous Waste Management program under the Resource Conservation and Recovery Act (RCRA), the Underground Injection Control (UIC) program under the Safe Drinking Water Act (SDWA), the National Pollutant Discharge Elimination System (NPDES) program and State Dredge on Fill ("404") programs under the Clean Water Act (CWA), and the Prevention of Significant Deterioration (PSD) program under the Clean Air Act, for three primary purposes: (1) To consolidate program requirements for the RCRA and UIC programs with those already established for the NPDES program. (2) To establish requirements for State programs under the RCRA, UIC, and Section 404 programs. (3) To consolidate permit issuance procedures for EPA-issued Prevention of Significant Deterioration permits under the Clean Air Act with those for the RCRA, UIC, and NPDES programs. PMID:10246619

  17. 28 CFR Appendix C to Subpart G of... - Department Regulations Under Title VI of the Civil Rights Act of 1964 (28 CFR 42.106-42.110...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the Civil Rights Act of 1964 (28 CFR 42.106-42.110) Which Apply to This Subpart C Appendix C to... Activities-Implementation of Section 504 of the Rehabilitation Act of 1973 Pt. 42, Subpt. G, App. C Appendix C to Subpart G of Part 42—Department Regulations Under Title VI of the Civil Rights......

  18. 28 CFR Appendix C to Subpart G of... - Department Regulations Under Title VI of the Civil Rights Act of 1964 (28 CFR 42.106-42.110...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the Civil Rights Act of 1964 (28 CFR 42.106-42.110) Which Apply to This Subpart C Appendix C to... Activities-Implementation of Section 504 of the Rehabilitation Act of 1973 Pt. 42, Subpt. G, App. C Appendix C to Subpart G of Part 42—Department Regulations Under Title VI of the Civil Rights......

  19. 28 CFR Appendix C to Subpart G of... - Department Regulations Under Title VI of the Civil Rights Act of 1964 (28 CFR 42.106-42.110...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the Civil Rights Act of 1964 (28 CFR 42.106-42.110) Which Apply to This Subpart C Appendix C to... Activities-Implementation of Section 504 of the Rehabilitation Act of 1973 Pt. 42, Subpt. G, App. C Appendix C to Subpart G of Part 42—Department Regulations Under Title VI of the Civil Rights......

  20. 28 CFR Appendix C to Subpart G of... - Department Regulations Under Title VI of the Civil Rights Act of 1964 (28 CFR 42.106-42.110...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the Civil Rights Act of 1964 (28 CFR 42.106-42.110) Which Apply to This Subpart C Appendix C to... Activities-Implementation of Section 504 of the Rehabilitation Act of 1973 Pt. 42, Subpt. G, App. C Appendix C to Subpart G of Part 42—Department Regulations Under Title VI of the Civil Rights......

  1. An Arabidopsis F-box protein acts as a transcriptional co-factor to regulate floral development.

    PubMed

    Chae, Eunyoung; Tan, Queenie K-G; Hill, Theresa A; Irish, Vivian F

    2008-04-01

    Plants flower in response to both environmental and endogenous signals. The Arabidopsis LEAFY (LFY) transcription factor is crucial in integrating these signals, and acts in part by activating the expression of multiple floral homeotic genes. LFY-dependent activation of the homeotic APETALA3 (AP3) gene requires the activity of UNUSUAL FLORAL ORGANS (UFO), an F-box component of an SCF ubiquitin ligase, yet how this regulation is effected has remained unclear. Here, we show that UFO physically interacts with LFY both in vitro and in vivo, and this interaction is necessary to recruit UFO to the AP3 promoter. Furthermore, a transcriptional repressor domain fused to UFO reduces endogenous LFY activity in plants, supporting the idea that UFO acts as part of a transcriptional complex at the AP3 promoter. Moreover, chemical or genetic disruption of proteasome activity compromises LFY-dependent AP3 activation, indicating that protein degradation is required to promote LFY activity. These results define an unexpected role for an F-box protein in functioning as a DNA-associated transcriptional co-factor in regulating floral homeotic gene expression. These results suggest a novel mechanism for promoting flower development via protein degradation and concomitant activation of the LFY transcription factor. This mechanism may be widely conserved, as homologs of UFO and LFY have been identified in a wide array of plant species. PMID:18287201

  2. The exosome and trans-acting small interfering RNAs regulate cuticular wax biosynthesis during Arabidopsis inflorescence stem development.

    PubMed

    Lam, Patricia; Zhao, Lifang; Eveleigh, Nathan; Yu, Yu; Chen, Xuemei; Kunst, Ljerka

    2015-02-01

    The primary aerial surfaces of land plants are covered with a cuticle, a protective layer composed of the cutin polyester matrix and cuticular waxes. Previously, we discovered a unique mechanism of regulating cuticular wax biosynthesis during Arabidopsis (Arabidopsis thaliana) stem elongation that involves ECERIFERUM7 (CER7), a core subunit of the exosome. Because loss-of-function mutations in CER7 result in reduced expression of the wax biosynthetic gene CER3, we proposed that CER7 is involved in degrading a messenger RNA encoding a CER3 repressor. To identify this putative repressor, we performed a cer7 suppressor screen that resulted in the isolation of the posttranscriptional gene-silencing components RNA-DEPENDENT RNA POLYMERASE1 and SUPPRESSOR OF GENE SILENCING3, indicating that small RNAs regulate CER3 expression. To establish the identity of the effector RNA species and determine whether these RNAs control CER3 transcript levels directly, we cloned additional genes identified in our suppressor screen and performed next-generation sequencing of small RNA populations that differentially accumulate in the cer7 mutant in comparison with the wild type. Our results demonstrate that the trans-acting small interfering RNA class of small RNAs are the effector molecules involved in direct silencing of CER3 and that the expression of five additional genes (EARLY RESPONSE TO DEHYDRATION14, AUXIN RESISTANT1, a translation initiation factor SUI1 family protein, and two genes of unknown function) is controlled by both CER7 and trans-acting small interfering RNAs.

  3. An Arabidopsis F-box protein acts as a transcriptional co-factor to regulate floral development.

    PubMed

    Chae, Eunyoung; Tan, Queenie K-G; Hill, Theresa A; Irish, Vivian F

    2008-04-01

    Plants flower in response to both environmental and endogenous signals. The Arabidopsis LEAFY (LFY) transcription factor is crucial in integrating these signals, and acts in part by activating the expression of multiple floral homeotic genes. LFY-dependent activation of the homeotic APETALA3 (AP3) gene requires the activity of UNUSUAL FLORAL ORGANS (UFO), an F-box component of an SCF ubiquitin ligase, yet how this regulation is effected has remained unclear. Here, we show that UFO physically interacts with LFY both in vitro and in vivo, and this interaction is necessary to recruit UFO to the AP3 promoter. Furthermore, a transcriptional repressor domain fused to UFO reduces endogenous LFY activity in plants, supporting the idea that UFO acts as part of a transcriptional complex at the AP3 promoter. Moreover, chemical or genetic disruption of proteasome activity compromises LFY-dependent AP3 activation, indicating that protein degradation is required to promote LFY activity. These results define an unexpected role for an F-box protein in functioning as a DNA-associated transcriptional co-factor in regulating floral homeotic gene expression. These results suggest a novel mechanism for promoting flower development via protein degradation and concomitant activation of the LFY transcription factor. This mechanism may be widely conserved, as homologs of UFO and LFY have been identified in a wide array of plant species.

  4. RCRA Part A Permit Application for Waste Management Activities at the Nevada Test Site, Part B Permit Application Hazardous Waste Storage Unit, Nevada Test Site, and Part B Permit Application - Explosives Ordnance Disposal Unit (EODU)

    SciTech Connect

    NSTec Environmental Programs

    2010-06-17

    The Area 5 Hazardous Waste Storage Unit (HWSU) was established to support testing, research, and remediation activities at the Nevada Test Site (NTS), a large-quantity generator of hazardous waste. The HWSU, located adjacent to the Area 5 Radioactive Waste Management Site (RWMS), is a prefabricated, rigid steel-framed, roofed shelter used to store hazardous nonradioactive waste generated on the NTS. No offsite generated wastes are managed at the HWSU. Waste managed at the HWSU includes the following categories: Flammables/Combustibles; Acid Corrosives; Alkali Corrosives; Oxidizers/Reactives; Toxics/Poisons; and Other Regulated Materials (ORMs). A list of the regulated waste codes accepted for storage at the HWSU is provided in Section B.2. Hazardous wastes stored at the HWSU are stored in U.S. Department of Transportation (DOT) compliant containers, compatible with the stored waste. Waste transfer (between containers) is not allowed at the HWSU and containers remain closed at all times. Containers are stored on secondary containment pallets and the unit is inspected monthly. Table 1 provides the metric conversion factors used in this application. Table 2 provides a list of existing permits. Table 3 lists operational Resource Conservation and Recovery Act (RCRA) units at the NTS and their respective regulatory status.

  5. ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer.

    PubMed

    Lin, Li-Fang; Chuang, Chih-Hung; Li, Chien-Feng; Liao, Ching-Chun; Cheng, Chun-Pei; Cheng, Tian-Lu; Shen, Meng-Ru; Tseng, Joseph T; Chang, Wen-Chang; Lee, Wen-Hwa; Wang, Ju-Ming

    2010-01-01

    The BRCA1-interacted transcriptional repressor ZBRK1 has been associated with antiangiogenesis, but direct evidence of a tumor suppressor role has been lacking. In this study, we provide evidence of such a role in cervical carcinoma. ZBRK1 levels in cervical tumor cells were significantly lower than in normal cervical epithelial cells. In HeLa cervical cancer cells, enforced expression inhibited malignant growth, invasion, and metastasis in a variety of in vitro and in vivo assays. Expression of the metalloproteinase MMP9, which is known to be an important driver of invasion and metastasis, was found to be inversely correlated with ZBRK1 in tumor tissues and a target for repression in tumor cells. Our findings suggest that ZBRK1 acts to inhibit metastasis of cervical carcinoma, perhaps by modulating MMP9 expression.

  6. The Texas space flight liability act and efficient regulation for the private commercial space flight era

    NASA Astrophysics Data System (ADS)

    Johnson, Christopher D.

    2013-12-01

    In the spring of 2011, the American state of Texas passed into law an act limiting the liability of commercial space flight entities. Under it, those companies would not be liable for space flight participant injuries, except in cases of intentional injury or injury proximately caused by the company's gross negligence. An analysis within the framework of international and national space law, but especially informed by the academic discipline of law and economics, discusses the incentives of all relevant parties and attempts to understand whether the law is economically "efficient" (allocating resources so as to yield maximum utility), and suited to further the development of the fledgling commercial suborbital tourism industry. Insights into the Texas law are applicable to other states hoping to foster commercial space tourism and considering space tourism related legislation.

  7. The Clean Air Act strictly regulates electric utility emissions and utilities are reducing their emissions significantly

    SciTech Connect

    Kinsman, J.D.

    1998-12-31

    Electric utility SO{sub 2} and NO{sub x} emissions have been reduced tremendously, beginning before the first deadlines (1995 for SO{sub 2} and 1996 for NO{sub x}) of the 1990 Clean Air Act Amendments. For the Acid Rain Program, EPA reports that: (1) all 445 affected facilities demonstrated 100 percent compliance for both pollutants and even exceeded the compliance targets; (2) the Acid Rain Program has been very successful; and (3) due to these and other controls, air quality has improved in the United States. Furthermore, the new 8-hour ozone standard, the new PM2.5 standards, the EPA`s 22-state regional NO{sub x} program, the Northeast state petitions for upwind NO{sub x} reductions and EPA`s regional haze proposal will likely lead to substantially greater reductions of utility SO{sub 2} and NO{sub x}.

  8. Polyadenylation in Rice Tungro Bacilliform Virus: cis-Acting Signals and Regulation

    PubMed Central

    Rothnie, Helen M.; Chen, Gang; Fütterer, Johannes; Hohn, Thomas

    2001-01-01

    The polyadenylation signal of rice tungro bacilliform virus (RTBV) was characterized by mutational and deletion analysis. The cis-acting signals required to direct polyadenylation conformed to what is known for plant poly(A) signals in general and were very similar to those of the related cauliflower mosaic virus. Processing was directed by a canonical AAUAAA poly(A) signal, an upstream UG-rich region considerably enhanced processing efficiency, and sequences downstream of the cleavage site were not required. When present at the end of a transcription unit, the cis-acting signals for 3′-end processing were highly efficient in both monocot (rice) and dicot (Nicotiana plumbaginifolia) protoplasts. In a promoter-proximal position, as in the viral genome, the signal was also efficiently processed in rice protoplasts, giving rise to an abundant “short-stop” (SS-) RNA. The proportion of SS-RNA was considerably lower in N. plumbaginifolia protoplasts. In infected plants, SS-RNA was hardly detectable, suggesting either that SS-RNA is unstable in infected plants or that read-through of the promoter-proximal poly(A) site is very efficient. SS-RNA is readily detectable in transgenic rice plants (A. Klöti, C. Henrich, S. Bieri, X. He, G. Chen, P. K. Burkhardt, J. Wünn, P. Lucca, T. Hohn, I. Potrylus, and J. Fütterer, 1999. Plant Mol. Biol. 40:249–266), thus the absence of SS-RNA in infected plants can be attributed to poly(A) site bypass in the viral context to ensure production of the full-length pregenomic viral RNA. RTBV poly(A) site suppression thus depends both on context and the expression system; our results suggest that the circular viral minichromosome directs assembly of a transcription-processing complex with specific properties to effect read-through of the promoter-proximal poly(A) signal. PMID:11287568

  9. Federal Environmental Regulations Impacting Hydrocarbon Exploration, Drilling, and Production Operations

    SciTech Connect

    Carroll, Herbert B.; Johnson, William I.

    1999-04-27

    Waste handling and disposal from hydrocarbon exploration, drilling, and production are regulated by the US Environmental Protection Agency (EPA) through federal and state regulations and/or through implementation of federal regulations. Some wastes generated in these operations are exempt under the Resource Conservation and Recovery Act (RCRA) but are not exempt under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), Superfund Amendments and Reauthorization Act (SARA), and other federal environmental laws. Exempt wastes remain exempt only if they are not mixed with hazardous wastes or hazardous substances. Once mixture occurs, the waste must be disposed as a hazardous material in an approved hazardous waste disposal facility. Before the Clean Air Act as amended in 1990, air emissions from production, storage, steam generation, and compression facilities associated with hydrocarbon exploration, drilling, and production industry were not regulated. A critical proposed regulatory change which will significantly effect Class II injection wells for disposal of produced brine and injection for enhanced oil recovery is imminent. Federal regulations affecting hydrocarbon exploration, drilling and production, proposed EPA regulatory changes, and a recent significant US Court of Appeals decision are covered in this report. It appears that this industry will, in the future, fall under more stringent environmental regulations leading to increased costs for operators.

  10. Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism.

    PubMed

    Atkins, Gerald J; Rowe, Peter S; Lim, Hui P; Welldon, Katie J; Ormsby, Renee; Wijenayaka, Asiri R; Zelenchuk, Lesya; Evdokiou, Andreas; Findlay, David M

    2011-07-01

    The identity of the cell type responsive to sclerostin, a negative regulator of bone mass, is unknown. Since sclerostin is expressed in vivo by mineral-embedded osteocytes, we tested the hypothesis that sclerostin would regulate the behavior of cells actively involved in mineralization in adult bone, the preosteocyte. Differentiating cultures of human primary osteoblasts exposed to recombinant human sclerostin (rhSCL) for 35 days displayed dose- and time-dependent inhibition of in vitro mineralization, with late cultures being most responsive in terms of mineralization and gene expression. Treatment of advanced (day 35) cultures with rhSCL markedly increased the expression of the preosteocyte marker E11 and decreased the expression of mature markers DMP1 and SOST. Concomitantly, matrix extracellular phosphoglycoprotein (MEPE) expression was increased by rhSCL at both the mRNA and protein levels, whereas PHEX was decreased, implying regulation through the MEPE-ASARM axis. We confirmed that mineralization by human osteoblasts is exquisitely sensitive to the triphosphorylated ASARM-PO4 peptide. Immunostaining revealed that rhSCL increased the endogenous levels of MEPE-ASARM. Importantly, antibody-mediated neutralization of endogenous MEPE-ASARM antagonized the effect of rhSCL on mineralization, as did the PHEX synthetic peptide SPR4. Finally, we found elevated Sost mRNA expression in the long bones of HYP mice, suggesting that sclerostin may drive the increased MEPE-ASARM levels and mineralization defect in this genotype. Our results suggest that sclerostin acts through regulation of the PHEX/MEPE axis at the preosteocyte stage and serves as a master regulator of physiologic bone mineralization, consistent with its localization in vivo and its established role in the inhibition of bone formation.

  11. Summary of Model Toxics Control Act (MTCA) Potential Impacts Related to Hanford Cleanup and the Tri-Party Agreement (TPA)

    SciTech Connect

    IWATATE, D.F.

    2000-07-14

    This white paper provides an initial assessment of the potential impacts of the Model Toxics Control Act (MTCA) regulations (and proposed revisions) on the Hanford site cleanup and addresses concerns that MTCA might impose inappropriate or unachievable clean-up levels and drive clean-up costs higher. The white paper and supporting documentation (Appendices A and B) provide DOE with a concise and up-to-date review of potential MTCA impacts to cost and schedule for the Hanford site activities. MTCA, Chapter 70.105D RCW, is the State of Washington's risk based law governing clean-up of contaminated sites and is implemented by The Washington Department of Ecology (Ecology) under the MTCA Clean-up Regulations, Chapter 173-340 WAC. Hanford cleanup is subject to the MTCA requirements as Applicable, Relevant and Appropriate Requirements (ARARs) for those areas of Hanford being managed under the authority of the Federal Resource Conservation and Recovery Act (RCRA), Comprehensive Environmental Response, Compensation and Liability Act (CERCLA), and the state Dangerous Waste Regulations. MTCA provides Ecology with authority to implement site clean-up actions under both the federal RCRA and CERCLA regulations as well as the state regulations. Most of the Hanford clean-up actions are being implemented under the CERCLA program, however, there is a trend is toward increased use of MTCA procedures and standards. The application of MTCA to the Hanford clean-up has been an evolving process with some of the Hanford clean-up actions considering MTCA standards as an ARAR and using MTCA procedures for remedy selection. The increased use and application of MTCA standards and procedures could potentially impact both cost and schedule for the Hanford cleanup.

  12. Cyclic AMP Receptor Protein Acts as a Transcription Regulator in Response to Stresses in Deinococcus radiodurans

    PubMed Central

    Wang, Jiali; Liu, Chengzhi; Lu, Huizhi; Liu, Mengjia; Zhao, Ye; Tian, Bing; Wang, Liangyan; Hua, Yuejin

    2016-01-01

    The cyclic AMP receptor protein family of transcription factors regulates various metabolic pathways in bacteria, and also play roles in response to environmental changes. Here, we identify four homologs of the CRP family in Deinococcus radiodurans, one of which tolerates extremely high levels of oxidative stress and DNA-damaging reagents. Transcriptional levels of CRP were increased under hydrogen peroxide (H2O2) treatment during the stationary growth phase, indicating that CRPs function in response to oxidative stress. By constructing all CRP single knockout mutants, we found that the dr0997 mutant showed the lowest tolerance toward H2O2, ultraviolet radiation, ionizing radiation, and mitomycin C, while the phenotypes of the dr2362, dr0834, and dr1646 mutants showed slight or no significant differences from those of the wild-type strain. Taking advantage of the conservation of the CRP-binding site in many bacteria, we found that transcription of 18 genes, including genes encoding chromosome-partitioning protein (dr0998), Lon proteases (dr0349 and dr1974), NADH-quinone oxidoreductase (dr1506), thiosulfate sulfurtransferase (dr2531), the DNA repair protein UvsE (dr1819), PprA (dra0346), and RecN (dr1447), are directly regulated by DR0997. Quantitative real-time polymerase chain reaction (qRT-PCR) analyses showed that certain genes involved in anti-oxidative responses, DNA repair, and various cellular pathways are transcriptionally attenuated in the dr0997 mutant. Interestingly, DR0997 also regulate the transcriptional levels of all CRP genes in this bacterium. These data suggest that DR0997 contributes to the extreme stress resistance of D. radiodurans via its regulatory role in multiple cellular pathways, such as anti-oxidation and DNA repair pathways. PMID:27182600

  13. Employee Retirement Income Security Act of 1974; rules and regulations for administration and enforcement; claims procedure. Final regulation; delay of applicability date.

    PubMed

    2001-07-01

    This action delays for at least six months and not more than one year the applicability date for the regulation governing minimum requirements for benefit claims procedures of group health plans covered by Title I of the Employee Retirement Income Security Act. As published on November 21, 2000, the benefit claims procedure would be applicable to claims filed on or after January 1, 2002. The current action amends the regulation so that it will apply to group health claims filed on or after the first day of the first plan year beginning on or after July 1, 2002, but in no event later than January 1, 2003. This action provides a limited additional period within which group health plan sponsors, administrators, and service providers can bring their claims processing systems into compliance with the new requirements. A postponement of the applicability date with respect to group health claims will allow a more orderly transition to the new standards and will avoid the confusion and additional expense that would be caused if certain pending Congressional bills are enacted before or soon after the original applicability date. This action does not apply to pension plans or plans providing disability or welfare benefits (other than group health). For these plans, the regulation will continue to be applicable to claims filed on or after January 1, 2002.

  14. Two-Step Regulation of a Meristematic Cell Population Acting in Shoot Branching in Arabidopsis

    PubMed Central

    Tian, Caihuan; Wang, Jin; Xu, Tengfei; Xu, Yan; Ohno, Carolyn; Sablowski, Robert; Heisler, Marcus G.; Theres, Klaus; Wang, Ying

    2016-01-01

    Shoot branching requires the establishment of new meristems harboring stem cells; this phenomenon raises questions about the precise regulation of meristematic fate. In seed plants, these new meristems initiate in leaf axils to enable lateral shoot branching. Using live-cell imaging of leaf axil cells, we show that the initiation of axillary meristems requires a meristematic cell population continuously expressing the meristem marker SHOOT MERISTEMLESS (STM). The maintenance of STM expression depends on the leaf axil auxin minimum. Ectopic expression of STM is insufficient to activate axillary buds formation from plants that have lost leaf axil STM expressing cells. This suggests that some cells undergo irreversible commitment to a developmental fate. In more mature leaves, REVOLUTA (REV) directly up-regulates STM expression in leaf axil meristematic cells, but not in differentiated cells, to establish axillary meristems. Cell type-specific binding of REV to the STM region correlates with epigenetic modifications. Our data favor a threshold model for axillary meristem initiation, in which low levels of STM maintain meristematic competence and high levels of STM lead to meristem initiation. PMID:27398935

  15. Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass

    PubMed Central

    Decker, Corinne E.; Yang, Zhengfeng; Rimer, Ryan; Park-Min, Kyung-Hyun; Macaubas, Claudia; Mellins, Elizabeth D.; Novack, Deborah V.; Faccio, Roberta

    2015-01-01

    Phospholipase C gamma-2 (PLCγ2)-dependent calcium (Ca2+) oscillations are indispensable for nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) activation and downstream gene transcription driving osteoclastogenesis during skeletal remodeling and pathological bone loss. Here we describe, to our knowledge, the first known function of transmembrane protein 178 (Tmem178), a PLCγ2 downstream target gene, as a critical modulator of the NFATc1 axis. In surprising contrast to the osteopetrotic phenotype of PLCγ2−/− mice, Tmem178−/− mice are osteopenic in basal conditions and are more susceptible to inflammatory bone loss, owing to enhanced osteoclast formation. Mechanistically, Tmem178 localizes to the ER membrane and regulates RANKL-induced Ca2+ fluxes, thus controlling NFATc1 induction. Importantly, down-regulation of Tmem178 is observed in human CD14+ monocytes exposed to plasma from systemic juvenile idiopathic arthritis patients. Similar to the mouse model, reduced Tmem178 expression in human cells correlates with excessive osteoclastogenesis. In sum, these findings identify an essential role for Tmem178 to maintain skeletal mass and limit pathological bone loss. PMID:26644563

  16. PP2A and GSK-3beta act antagonistically to regulate active zone development.

    PubMed

    Viquez, Natasha M; Füger, Petra; Valakh, Vera; Daniels, Richard W; Rasse, Tobias M; DiAntonio, Aaron

    2009-09-16

    The synapse is composed of an active zone apposed to a postsynaptic cluster of neurotransmitter receptors. Each Drosophila neuromuscular junction comprises hundreds of such individual release sites apposed to clusters of glutamate receptors. Here, we show that protein phosphatase 2A (PP2A) is required for the development of structurally normal active zones opposite glutamate receptors. When PP2A is inhibited presynaptically, many glutamate receptor clusters are unapposed to Bruchpilot (Brp), an active zone protein required for normal transmitter release. These unapposed receptors are not due to presynaptic retraction of synaptic boutons, since other presynaptic components are still apposed to the entire postsynaptic specialization. Instead, these data suggest that Brp localization is regulated at the level of individual release sites. Live imaging of glutamate receptors demonstrates that this disruption to active zone development is accompanied by abnormal postsynaptic development, with decreased formation of glutamate receptor clusters. Remarkably, inhibition of the serine-threonine kinase GSK-3beta completely suppresses the active zone defect, as well as other synaptic morphology phenotypes associated with inhibition of PP2A. These data suggest that PP2A and GSK-3beta function antagonistically to control active zone development, providing a potential mechanism for regulating synaptic efficacy at a single release site.

  17. Characterization of Vadose Zone Sediment: Uncontaminated RCRA Borehole Core Samples and Composite Samples

    SciTech Connect

    Serne, R. Jeffrey; Bjornstad, Bruce N.; Schaef, Herbert T.; Williams, Bruce A.; Lanigan, David C.; Horton, Duane G.; Clayton, Ray E.; Mitroshkov, Alexandre V.; Legore, Virginia L.; O'Hara, Matthew J.; Brown, Christopher F.; Parker, Kent E.; Kutnyakov, Igor V.; Serne, Jennifer N.; Last, George V.; Smith, Steven C.; Lindenmeier, Clark W.; Zachara, John M.; Burke, Deborah S.

    2008-09-11

    This report was revised in September 2008 to remove acid-extractable sodium data from Tables 4.14, 4.16, 5.20, 5.22, 5.43, and 5.45. The sodium data was removed due to potential contamination introduced during the acid extraction process. The rest of the text remains unchanged from the original report issued in February 2002. The overall goal of the of the Tank Farm Vadose Zone Project, led by CH2M HILL Hanford Group, Inc., is to define risks from past and future single-shell tank farm activities. To meet this goal, CH2M HILL Hanford Group, Inc. asked scientists from Pacific Northwest National Laboratory to perform detailed analyses on vadose zone sediment from within the S-SX Waste Management Area. This report is one in a series of four reports to present the results of these analyses. Specifically, this report contains all the geologic, geochemical, and selected physical characterization data collected on vadose zone sediment recovered from Resource Conservation and Recovery Act (RCRA) borehole bore samples and composite samples.

  18. Ubiquitin-Fold Modifier 1 Acts as a Positive Regulator of Breast Cancer

    PubMed Central

    Yoo, Hee Min; Park, Jong Ho; Jeon, Young Joo; Chung, Chin Ha

    2015-01-01

    Estrogen receptor-α (ERα) is a steroid hormone-sensitive transcription factor that plays a critical role in development of breast cancer. The binding of estrogen to ERα triggers the recruitment of transcriptional co-activators as well as chromatin remodeling factors to estrogen-responsive elements (ERE) of ERα target genes. This process is tightly associated with post-translational modifications (PTMs) of ERα and its co-activators for promotion of transcriptional activation, which leads to proliferation of a large subset of breast tumor cells. These PTMs include phosphorylation, acetylation, methylation, and conjugation by ubiquitin and ubiquitin-like proteins. Ubiquitin-fold modifier 1 (UFM1), one of ubiquitin-like proteins, has recently been shown to be ligated to activating signal co-integrator 1 (ASC1), which acts as a transcriptional co-activator of nuclear receptors. Here, we discuss the mechanistic connection between ASC1 modification by UFM1 and ERα transactivation, and highlight how the interplay of these processes is involved in development of breast cancer. We also discuss potential use of UFM1-conjugating system as therapeutic targets against not only breast cancer but also other nuclear receptor-mediated cancers. PMID:25852645

  19. LGI1 acts presynaptically to regulate excitatory synaptic transmission during early postnatal development

    PubMed Central

    Boillot, Morgane; Lee, Chun-Yao; Allene, Camille; Leguern, Eric; Baulac, Stéphanie; Rouach, Nathalie

    2016-01-01

    The secreted leucine-rich glioma inactivated 1 (LGI1) protein is an important actor for human seizures of both genetic and autoimmune etiology: mutations in LGI1 cause inherited temporal lobe epilepsy, while LGI1 is involved in antibody-mediated encephalitis. Remarkably, Lgi1-deficient (Lgi1−/−) mice recapitulate the epileptic disorder and display early-onset spontaneous seizures. To understand how Lgi1-deficiency leads to seizures during postnatal development, we here investigated the early functional and structural defects occurring before seizure onset in Lgi1−/− mice. We found an increased excitatory synaptic transmission in hippocampal slices from Lgi1−/− mice. No structural alteration in the morphology of pyramidal cell dendrites and synapses was observed at this stage, indicating that Lgi1-deficiency is unlikely to trigger early developmental abnormalities. Consistent with the presynaptic subcellular localization of the protein, Lgi1-deficiency caused presynaptic defects, with no alteration in postsynaptic AMPA receptor activity in Lgi1−/− pyramidal cells before seizure onset. Presynaptic dysfunction led to increased synaptic glutamate levels, which were associated with hyperexcitable neuronal networks. Altogether, these data show that Lgi1 acts presynaptically as a negative modulator of excitatory synaptic transmission during early postnatal development. We therefore here reveal that increased presynaptic glutamate release is a key early event resulting from Lgi1-deficiency, which likely contributes to epileptogenesis. PMID:26878798

  20. LGI1 acts presynaptically to regulate excitatory synaptic transmission during early postnatal development.

    PubMed

    Boillot, Morgane; Lee, Chun-Yao; Allene, Camille; Leguern, Eric; Baulac, Stéphanie; Rouach, Nathalie

    2016-01-01

    The secreted leucine-rich glioma inactivated 1 (LGI1) protein is an important actor for human seizures of both genetic and autoimmune etiology: mutations in LGI1 cause inherited temporal lobe epilepsy, while LGI1 is involved in antibody-mediated encephalitis. Remarkably, Lgi1-deficient (Lgi1(-/-)) mice recapitulate the epileptic disorder and display early-onset spontaneous seizures. To understand how Lgi1-deficiency leads to seizures during postnatal development, we here investigated the early functional and structural defects occurring before seizure onset in Lgi1(-/-) mice. We found an increased excitatory synaptic transmission in hippocampal slices from Lgi1(-/-) mice. No structural alteration in the morphology of pyramidal cell dendrites and synapses was observed at this stage, indicating that Lgi1-deficiency is unlikely to trigger early developmental abnormalities. Consistent with the presynaptic subcellular localization of the protein, Lgi1-deficiency caused presynaptic defects, with no alteration in postsynaptic AMPA receptor activity in Lgi1-/- pyramidal cells before seizure onset. Presynaptic dysfunction led to increased synaptic glutamate levels, which were associated with hyperexcitable neuronal networks. Altogether, these data show that Lgi1 acts presynaptically as a negative modulator of excitatory synaptic transmission during early postnatal development. We therefore here reveal that increased presynaptic glutamate release is a key early event resulting from Lgi1-deficiency, which likely contributes to epileptogenesis. PMID:26878798