Science.gov

Sample records for act regulations requirements

  1. 21 CFR 16.24 - Regulatory hearing required by the act or a regulation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... regulation. 16.24 Section 16.24 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN....24 Regulatory hearing required by the act or a regulation. (a) A regulatory hearing required by the act or a regulation under § 16.1(b) will be initiated in the same manner as other regulatory...

  2. 21 CFR 16.24 - Regulatory hearing required by the act or a regulation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... regulation. 16.24 Section 16.24 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN....24 Regulatory hearing required by the act or a regulation. (a) A regulatory hearing required by the act or a regulation under § 16.1(b) will be initiated in the same manner as other regulatory...

  3. 78 FR 27308 - Loan Originator Compensation Requirements Under the Truth In Lending Act (Regulation Z...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-10

    ... adopting Sec. 1026.36(i). \\1\\ 78 FR 11279 (Feb. 15, 2013). A. Title XIV Rulemaking Effective Dates In... become effective sooner than January 2014.\\5\\ \\5\\ 77 FR 55272 (Sept. 7, 2012). The Bureau received very... Requirements Under the Truth In Lending Act (Regulation Z); Prohibition on Financing Credit Insurance...

  4. 77 FR 33635 - Amendment to the Bank Secrecy Act Regulations-Requirement That Clerks of Court Report Certain...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-07

    ...\\ 66 FR 67680 (December 31, 2001), codified at 31 CFR 1010.330. \\7\\ 26 CFR 1.6050I-1. As amended... Financial Crimes Enforcement Network 31 CFR Part 1010 RIN 1506-AB17 Amendment to the Bank Secrecy Act Regulations--Requirement That Clerks of Court Report Certain Currency Transactions AGENCY: Financial...

  5. 78 FR 4725 - Escrow Requirements Under the Truth in Lending Act (Regulation Z)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ... persons excluded from coverage by section 1029 of the Dodd-Frank Act). See 76 FR 79768 (Dec. 22, 2011... granted to the Board by the Home Ownership and Equity Protection Act of 1994 (HOEPA). See 73 FR 44522... of sections 1461 and 1462 of the Dodd-Frank Act. 76 FR 11598 (Mar. 2, 2011) (the Board's 2011...

  6. Impacts & Compliance Implementation Plans & Required Deviations for Toxic Substance Control Act (TSCA) Regulation of Double Shell Tanks (DST)

    SciTech Connect

    MULKEY, C.H.

    2000-08-22

    In May 2000, the U.S. Department of Energy, Office of River Protection (DOE-ORP) and the U.S. Environmental Protection Agency (EPA) held meetings regarding the management of polychlorinated biphenyls (PCBs) in the Hanford tank waste. It was decided that the radioactive waste currently stored in the double-shell tanks (DSTs) contain waste which will become subject to the Toxic Substance Control Act (TSCA) (40 CFR 761). As a result, DOE-ORP directed the River Protection Project tank farm contractor (TFC) to prepare plans for managing the PCB inventory in the DSTs. Two components of the PCB management plans are this assessment of the operational impacts of TSCA regulation and the identifications of deviations from TSCA that are required to accommodate tank farm unique limitations. This plan provides ORP and CH2M HILL Hanford Group, Inc. (CHG) with an outline of TSCA PCB requirements and their applicability to tank farm activities, and recommends a compliance/implementation approach. Where strict compliance is not possible, the need for deviations from TSCA PCB requirements is identified. The purpose of assembling this information is to enhance the understanding of PCB management requirements, identify operational impacts and select impact mitigation strategies. This information should be useful in developing formal agreements with EPA where required.

  7. 75 FR 44163 - Implementation of Regulations Required Under Title XI of the Food, Conservation and Energy Act of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-28

    ... Administration (GIPSA) published a proposed rule in the Federal Register on June 22, 2010 (75 FR 35338) proposing...; ] DEPARTMENT OF AGRICULTURE Grain Inspection, Packers and Stockyards Administration 9 CFR Part 201 RIN 0580... 2008; Conduct in Violation of the Act AGENCY: Grain Inspection, Packers and Stockyards...

  8. 7 CFR 1948.65 - Relocation Act requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 13 2011-01-01 2009-01-01 true Relocation Act requirements. 1948.65 Section 1948.65...) PROGRAM REGULATIONS (CONTINUED) RURAL DEVELOPMENT Section 601 Energy Impacted Area Development Assistance Program § 1948.65 Relocation Act requirements. The policies and regulations contained in title 7,...

  9. 7 CFR 1948.65 - Relocation Act requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 13 2014-01-01 2013-01-01 true Relocation Act requirements. 1948.65 Section 1948.65...) PROGRAM REGULATIONS (CONTINUED) RURAL DEVELOPMENT Section 601 Energy Impacted Area Development Assistance Program § 1948.65 Relocation Act requirements. The policies and regulations contained in title 7,...

  10. 75 FR 35338 - Implementation of Regulations Required Under Title XI of the Food, Conservation and Energy Act of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-22

    ...; ] DEPARTMENT OF AGRICULTURE Grain Inspection, Packers and Stockyards Administration 9 CFR Part 201 RIN 0580..., USDA. ACTION: Proposed rule. SUMMARY: The Department of Agriculture (USDA), Grain Inspection, Packers... in the livestock and poultry industries and required the Secretary of Agriculture (Secretary)...

  11. 76 FR 76874 - Implementation of Regulations Required Under Title XI of the Food, Conservation and Energy Act of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-09

    ... on these comments. Section V provides the revised impact analyses including those required by..., (75 FR 35338) provided a 60-day comment period to end on August 23, 2010. In response to requests for... November 22, 2010 (75 FR 44163). GIPSA considered all comments postmarked or electronically submitted...

  12. The French Space Operation Act: Technical Regulations

    NASA Astrophysics Data System (ADS)

    Trinchero, J. P.; Lazare, B.

    2010-09-01

    The French Space Operation Act(FSOA) stipulates that a prime objective of the National technical regulations is to protect people, property, public health and the environment. Compliance with these technical regulations is mandatory as of 10 December 2010 for space operations by French space operators and for space operations from French territory. The space safety requirements and regulations governing procedures are based on national and international best practices and experience. A critical design review of the space system and procedures shall be carried out by the applicant, in order to verify compliance with the Technical Regulations. An independent technical assessment of the operation is delegated to CNES. The principles applied when drafting technical regulations are as follows: requirements must as far as possible establish the rules according to the objective to be obtained, rather than how it is to be achieved; requirements must give preference to international standards recognised as being the state of the art; requirements must take previous experience into account. Technical regulations are divided into three sections covering common requirements for the launch, control and return of a space object. A dedicated section will cover specific rules to be applied at the Guiana Space Centre. The main topics addressed by the technical regulations are: operator safety management system; study of risks to people, property, public health and the Earth’s environment; impact study on the outer space environment: space debris generated by the operation; planetary protection.

  13. The French Space Operations Act: Technical Regulations

    NASA Astrophysics Data System (ADS)

    Lazare, B.

    2013-12-01

    The French Space Operations Act (FSOA) [1] stipulates that one of the National Technical Regulations' prime objectives is to protect people, property, public health and the environment. Compliance with these Technical Regulations has been mandatory since 10 December, 2010 for space operations by French space operators and for space operations conducted on French territory. The space safety requirements and regulations governing procedures are based on national and international best practices and experience. A critical design review of the space system and procedures shall be carried out by applicant space operators, in order to verify compliance with the Technical Regulations. An independent technical assessment of the operation is delegated to CNES. The principles applied when drafting the Technical Regulations are as follows: requirements must, as far as possible, establish the rules according to the objective to be obtained, rather than how it is to be achieved; requirements must give preference to international standards recognised as being state of the art; requirements must take previous experience into account. The Technical Regulations are divided into three sections covering requirements common to the launch, control and return of a space object. A special section will cover specific rules to be applied at the Guiana Space Centre. The main topics addressed by the Technical Regulations are: operator safety management system; study of risks to people, property, public health and the Earth's environment; impact study on the outer space environment: space debris generated by the operation; planetary protection. The first version of the Technical Regulations [2], issued in March 2011, is dedicated to unmanned space systems.

  14. 75 FR 37287 - Privacy Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-29

    ... April 19, 2010 (75 FR 20298) for a public comment period to end on June 18, 2010. This rule amends the... CFR Part 200 RIN 0430-AA03 Privacy Act Regulations AGENCY: Recovery Accountability and Transparency... regulations implementing the Privacy Act of 1974 (Privacy Act), Public Law 93-579, 5 U.S.C. 552a. This...

  15. 75 FR 63703 - Privacy Act of 1974; Privacy Act Regulation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-18

    ... Federal Register, 73 FR 25594, May 7, 2008. The proposed amendments: (1) Waived all copying fees in..., 73 FR 54595, September 22, 2008, certain portions of BGFRS-37 (Electronic Applications) may be exempt... CFR Part 261a Privacy Act of 1974; Privacy Act Regulation AGENCY: Board of Governors of the...

  16. 75 FR 20298 - Privacy Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-19

    ...,'' pursuant to the Privacy Act, as amended (74 FR 60302, Nov. 20, 2009). The Board received no comments on...; ] RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD 4 CFR Part 200 RIN 0430-AA03 Privacy Act Regulations AGENCY... and Transparency Board (Board) proposes to amend the Board's regulations implementing the Privacy...

  17. 75 FR 58387 - Federal Acquisition Regulation; Information Collection; American Recovery and Reinvestment Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-24

    ... Regulation; Information Collection; American Recovery and Reinvestment Act-Reporting Requirements--One-Time... an extension of a currently approved information collection requirement concerning the American Recovery and Reinvestment Act-Reporting Requirements--One Time- Reporting, Compensation...

  18. cis-Acting Sequences Required for NtcB-Dependent, Nitrite-Responsive Positive Regulation of the Nitrate Assimilation Operon in the Cyanobacterium Synechococcus sp. Strain PCC 7942

    PubMed Central

    Maeda, Shin-Ichi; Kawaguchi, Yuriko; Ohe, Taka-Aki; Omata, Tatsuo

    1998-01-01

    There are three binding sites for NtcA (nirI, nirII, and nirIII), the global nitrogen regulator of cyanobacteria, in the DNA region between the two divergently transcribed operons (nirA and nirB operons) involved in nitrate assimilation in Synechococcus sp. strain PCC 7942. Using the luxAB reporter system, we showed that nirI and nirIII, which are located 23 bp upstream from the −10 promoter element of nirA and nirB, respectively, are required for induction by nitrogen depletion of the nirA and nirB operons, respectively. The induction of nirA operon transcription was a prerequisite for the nitrite-responsive positive regulation of the transcription by NtcB, a LysR-type protein. The NtcA-binding site nirII, located in the middle of the nirA-nirB intergenic region, and a potential binding site for a LysR-type protein (TGCAN5TGCA; designated L1), located between nirI and nirII, were required for the nitrite-responsive, NtcB-dependent enhancement of nirA operon transcription. Although the requirement for the L1 site was consistent with the involvement of the LysR family protein NtcB in transcriptional regulation, NtcB did not bind to the nirA regulatory region in vitro in the presence of nitrite and NtcA, suggesting the involvement of some additional factor(s) in the regulation. An L1-like inverted repeat with the consensus sequence TGCN7GCA was conserved in the nirA promoter region of cyanobacteria, being centered at position −23 with respect to the NtcA-binding site corresponding to nirI, which suggested the common occurrence of nitrite-responsive regulation of the nitrate assimilation operon among cyanobacteria. PMID:9696753

  19. 30 CFR 252.6 - Freedom of Information Act requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Section 252.6 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR... contained in 43 CFR part 2 (Records and Testimony), the requirements of the Act, and the regulations contained in 30 CFR parts 250 and 550 (Oil and Gas and Sulphur Operations in the Outer Continental...

  20. 30 CFR 252.6 - Freedom of Information Act requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Section 252.6 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR... contained in 43 CFR part 2 (Records and Testimony), the requirements of the Act, and the regulations contained in 30 CFR parts 250 and 550 (Oil and Gas and Sulphur Operations in the Outer Continental...

  1. 30 CFR 252.6 - Freedom of Information Act requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Section 252.6 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR... contained in 43 CFR part 2 (Records and Testimony), the requirements of the Act, and the regulations contained in 30 CFR parts 250 and 550 (Oil and Gas and Sulphur Operations in the Outer Continental...

  2. 7 CFR 3575.40 - Equal opportunity and Fair Housing Act requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Federal Reserve Board Regulation, 12 CFR part 202.) (b) Fair Housing Act. Certain housing-related projects... 7 Agriculture 15 2011-01-01 2011-01-01 false Equal opportunity and Fair Housing Act requirements... opportunity and Fair Housing Act requirements. (a) Equal Credit Opportunity Act. The lender will comply...

  3. 75 FR 58388 - Federal Acquisition Regulation; Information Collection; American Recovery and Reinvestment Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-24

    ... Regulation; Information Collection; American Recovery and Reinvestment Act-Reporting Requirements--Quarterly... an extension of a currently approved information collection requirement concerning the American Recovery and Reinvestment Act--Quarterly Reporting for Prime Contractors. Public comments are...

  4. 77 FR 43081 - Federal Acquisition Regulation; Information Collection; Buy American Act-Free Trade Agreements...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    ... Regulation; Information Collection; Buy American Act--Free Trade Agreements--Israeli Trade Act Certificate... previously approved information collection requirement concerning the Buy American Act--Free Trade Agreements..., Buy American Act--Free Trade Agreements--Israeli Trade Act Certificate, by any of the...

  5. 78 FR 17176 - Federal Acquisition Regulation; Defense Base Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-20

    ... Federal Acquisition Regulation; Defense Base Act AGENCIES: Department of Defense (DoD), General Services... Act as extended by the Defense Base Act. DATES: Interested parties should submit written comments to... Act as extended by the Defense Base Act. II. Discussion and Analysis The Defense Base Act of...

  6. 76 FR 24027 - Federal Acquisition Regulation; Information Collection; Buy American Act Certificate

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-29

    ... Regulation; Information Collection; Buy American Act Certificate AGENCY: Department of Defense (DOD), General... previously approved information collection requirement concerning the Buy American Act certificate. Public...-mail cecelia.davis@gsa.gov . SUPPLEMENTARY INFORMATION: A. Purpose The Buy American Act requires...

  7. Long-acting methods require special care.

    PubMed

    Blaney, C L

    1994-08-01

    Long-acting contraceptive methods including IUDs, implants, and sterilization are among the most effective and convenient contraceptive methods, requiring little or no effort on the part of the user once provided by a trained healthcare provider. Some women, however, oppose the development and use of provider-dependent contraceptive methods due to the potential for method misuse. These methods, for example, could be provided without women's fully informed choice, access to removal could be blocked, or the method could be provided to an inappropriate client. Making a contraceptive method unavailable because of potential abuse instead restricts women's reproductive choices. After all, abuse generally comes from the legal or delivery system, not from the method itself. Efforts should be made to satisfy users with standard norms for performance and without targets for specific methods. Good service delivery along with revised approaches to contraceptive introduction and program evaluation can help prevent inappropriate method use and ensure that women receive adequate information and counseling to help them make reproductive choices without undue influence. The author discusses Norplant delivery, providing IUDs, offering sterilization, and improving access.

  8. 47 CFR 1.990 - Citizenship and filing requirements under the Communications Act of 1934.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., as amended, 15 U.S.C. 78a et seq. (Exchange Act), and corresponding Exchange Act Rule 13d-1, 17 CFR... corresponding Exchange Act Rule 13d-1, 17 CFR 240.13d-1, or a substantially comparable foreign law or regulation... 47 Telecommunication 1 2013-10-01 2013-10-01 false Citizenship and filing requirements under...

  9. 47 CFR 1.990 - Citizenship and filing requirements under the Communications Act of 1934.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., as amended, 15 U.S.C. 78a et seq. (Exchange Act), and corresponding Exchange Act Rule 13d-1, 17 CFR... corresponding Exchange Act Rule 13d-1, 17 CFR 240.13d-1, or a substantially comparable foreign law or regulation... 47 Telecommunication 1 2014-10-01 2014-10-01 false Citizenship and filing requirements under...

  10. Regulation of the Osem gene by abscisic acid and the transcriptional activator VP1: analysis of cis-acting promoter elements required for regulation by abscisic acid and VP1.

    PubMed

    Hattori, T; Terada, T; Hamasuna, S

    1995-06-01

    Osem, a rice gene homologous to the wheat Em gene, which encodes one of the late-embryogenesis abundant proteins was isolated. The gene was characterized with respect to control of transcription by abscisic acid (ABA) and the transcriptional activator VP1, which is involved in the ABA-regulated gene expression during late embryo-genesis. A fusion gene (Osem-GUS) consisting of the Osem promoter and the bacterial beta-glucuronidase (GUS) gene was constructed and tested in a transient expression system, using protoplasts derived from a suspension-cultured line of rice cells, for activation by ABA and by co-transfection with an expression vector (35S-Osvp1) for the rice VP1 (OSVP1) cDNA. The expression of Osem-GUS was strongly (40- to 150-fold) activated by externally applied ABA and by over-expression of (OS)VP1. The Osem promoter has three ACGTG-containing sequences, motif A, motif B and motif A', which resemble the abscisic acid-responsive element (ABRE) that was previously identified in the wheat Em and the rice Rab16. There is also a CATGCATG sequence, which is known as the Sph box and is shown to be essential for the regulation by VP1 of the maize anthocyanin regulatory gene C1. Focusing on these sequence elements, various mutant derivatives of the Osem promoter in the transient expression system were assayed. The analysis revealed that motif A functions not only as an ABRE but also as a sequence element required for the regulation by (OS)VP1.

  11. Informational requirements for transcriptional regulation.

    PubMed

    O'Neill, Patrick K; Forder, Robert; Erill, Ivan

    2014-05-01

    Transcription factors (TFs) regulate transcription by binding to specific sites in promoter regions. Information theory provides a useful mathematical framework to analyze the binding motifs associated with TFs but imposes several assumptions that limit their applicability to specific regulatory scenarios. Explicit simulations of the co-evolution of TFs and their binding motifs allow the study of the evolution of regulatory networks with a high degree of realism. In this work we analyze the impact of differential regulatory demands on the information content of TF-binding motifs by means of evolutionary simulations. We generalize a predictive index based on information theory, and we validate its applicability to regulatory scenarios in which the TF binds significantly to the genomic background. Our results show a logarithmic dependence of the evolved information content on the occupancy of target sites and indicate that TFs may actively exploit pseudo-sites to modulate their occupancy of target sites. In regulatory networks with differentially regulated targets, we observe that information content in TF-binding motifs is dictated primarily by the fraction of total probability mass that the TF assigns to its target sites, and we provide a predictive index to estimate the amount of information associated with arbitrarily complex regulatory systems. We observe that complex regulatory patterns can exert additional demands on evolved information content, but, given a total occupancy for target sites, we do not find conclusive evidence that this effect is because of the range of required binding affinities. PMID:24689750

  12. 49 CFR 1105.9 - Coastal Zone Management Act requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Coastal Zone Management Act requirements. 1105.9... ENVIRONMENTAL LAWS § 1105.9 Coastal Zone Management Act requirements. (a) If the proposed action affects land or water uses within a State coastal zone designated pursuant to the Coastal Zone Management Act (16...

  13. Plainer Legal Language: Definitions and Requirements in Acts.

    ERIC Educational Resources Information Center

    Jordan, Michael P.

    1994-01-01

    Explores some of the stylistic complexities of definitions and requirements in a Canadian provincial act. Generates and justifies 15 recommendations for creating a plainer legal language in acts. (SR)

  14. 48 CFR 1480.102 - Buy Indian Act acquisition regulations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Buy Indian Act acquisition... INDIAN AFFAIRS SUPPLEMENT ACQUISITIONS UNDER THE BUY INDIAN ACT General 1480.102 Buy Indian Act... the Buy Indian Act. (b) This part is under the direct oversight and control of the Chief...

  15. NASA Principal Center for Review of Clean Air Act Regulations

    NASA Technical Reports Server (NTRS)

    Clark-Ingram, Marceia; Munafo, Paul M. (Technical Monitor)

    2002-01-01

    The Clean Air Act (CAA) regulations have greatly impacted materials and processes utilized in the manufacture of aerospace hardware. Code JE/ NASA's Environmental Management Division at NASA Headquarters recognized the need for a formal, Agency-wide review process of CAA regulations. Marshall Space Flight Center (MSFC) was selected as the 'Principal Center for Review of Clean Air Act Regulations'. This presentation describes the centralized support provided by MSFC for the management and leadership of NASA's CAA regulation review process.

  16. 3 CFR - Combating Noncompliance With Recovery Act Reporting Requirements

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 3 The President 1 2011-01-01 2011-01-01 false Combating Noncompliance With Recovery Act Reporting Requirements Presidential Documents Other Presidential Documents Memorandum of April 6, 2010 Combating Noncompliance With Recovery Act Reporting Requirements Memorandum for the Heads of Executive Departments and Agencies My Administration...

  17. 75 FR 5177 - Pipeline Posting Requirements under Section 23 of the Natural Gas Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-01

    ... clarification of Order No. 720. \\1\\ Pipeline Posting Requirements under section 23 of the Natural Gas Act, 73 FR... Natural Gas Act, 73 FR 1116 (Jan. 7, 2008), FERC Stats. & Regs., Proposed Regulations 2004-2007 ] 32,626.... 670, 71 FR 4244 (Jan. 26, 2006), FERC Stats. & Regs. ] 31,202 (2006). \\44\\ TPA Request for...

  18. 48 CFR 352.237-72 - Crime Control Act-requirement for background checks.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Crime Control Act... and Clauses 352.237-72 Crime Control Act—requirement for background checks. As prescribed in 337.103-70(c), the Contracting Officer shall insert the following clause: Crime Control Act of...

  19. 48 CFR 352.237-72 - Crime Control Act-requirement for background checks.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Crime Control Act... and Clauses 352.237-72 Crime Control Act—requirement for background checks. As prescribed in 337.103-70(c), the Contracting Officer shall insert the following clause: Crime Control Act of...

  20. 48 CFR 352.237-72 - Crime Control Act-requirement for background checks.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Crime Control Act... and Clauses 352.237-72 Crime Control Act—requirement for background checks. As prescribed in 337.103-70(c), the Contracting Officer shall insert the following clause: Crime Control Act of...

  1. 48 CFR 352.237-72 - Crime Control Act-requirement for background checks.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Crime Control Act... and Clauses 352.237-72 Crime Control Act—requirement for background checks. As prescribed in 337.103-70(c), the Contracting Officer shall insert the following clause: Crime Control Act of...

  2. 48 CFR 352.237-72 - Crime Control Act-requirement for background checks.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Crime Control Act... and Clauses 352.237-72 Crime Control Act—requirement for background checks. As prescribed in 337.103-70(c), the Contracting Officer shall insert the following clause: Crime Control Act of...

  3. 48 CFR 1480.102 - Buy Indian Act acquisition regulations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Buy Indian Act acquisition... INDIAN AFFAIRS SUPPLEMENT ACQUISITIONS UNDER THE BUY INDIAN ACT Subpart 1480.1 General 1480.102 Buy... in implementing the Buy Indian Act. (b) This part is under the direct oversight and control of...

  4. 13 CFR 108.30 - Amendments to Act and regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Amendments to Act and regulations. 108.30 Section 108.30 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION NEW MARKETS VENTURE CAPITAL (âNMVCâ) PROGRAM Introduction to Part 108 § 108.30 Amendments to Act and regulations. A...

  5. 13 CFR 107.30 - Amendments to Act and regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Amendments to Act and regulations. 107.30 Section 107.30 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS INVESTMENT COMPANIES Introduction to Part 107 § 107.30 Amendments to Act and regulations. A Licensee shall...

  6. 48 CFR 52.204-11 - American Recovery and Reinvestment Act-Reporting Requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Contractor shall report the following information, using the online reporting tool available at http://www... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false American Recovery and Reinvestment Act-Reporting Requirements. 52.204-11 Section 52.204-11 Federal Acquisition Regulations...

  7. 48 CFR 52.204-11 - American Recovery and Reinvestment Act-Reporting Requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Contractor shall report the following information, using the online reporting tool available at http://www... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false American Recovery and Reinvestment Act-Reporting Requirements. 52.204-11 Section 52.204-11 Federal Acquisition Regulations...

  8. 48 CFR 52.204-11 - American Recovery and Reinvestment Act-Reporting Requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Contractor shall report the following information, using the online reporting tool available at http://www... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false American Recovery and Reinvestment Act-Reporting Requirements. 52.204-11 Section 52.204-11 Federal Acquisition Regulations...

  9. 77 FR 75521 - Community Reinvestment Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-21

    ... 1, 2005. 70 FR 44256 (Aug. 2, 2005). As explained in the SUPPLEMENTARY INFORMATION section of these... Home Mortgage Disclosure Act (HMDA). 70 FR 12148 (Mar. 11, 2005). See 12 U.S.C. 2808; 12 CFR 203.2(e)(1... the other federal banking agencies in its CRA rule set forth at 12 CFR part 563e. 72 FR 13429 (Mar....

  10. 75 FR 36270 - Appraisal Subcommittee; Appraiser Regulation; Privacy Act Implementation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-25

    ... INSTITUTIONS EXAMINATION COUNCIL 12 CFR Part 1102 Appraisal Subcommittee; Appraiser Regulation; Privacy Act... (October 1998). List of Subjects in 12 CFR Part 1102 Administrative practice and procedure, Banks, banking... of the Code of Federal Regulations is amended as follows: PART 1102--APPRAISER REGULATION Subpart...

  11. 78 FR 79283 - Community Reinvestment Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... CRA purposes by the OCC, Board, and FDIC on August 2, 2005, effective September 1, 2005. 70 FR 44256... Act (HMDA). 70 FR 12148 (Mar. 11, 2005). See 12 U.S.C. 2808; 12 CFR 203.2(e)(1). On March 22, 2007... other federal banking agencies in its CRA rule previously set forth at 12 CFR 563e. 72 FR 13429 (Mar....

  12. 76 FR 79529 - Community Reinvestment Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-22

    ... adopted for CRA purposes by the OCC, Board, and FDIC on August 2, 2005, effective September 1, 2005. 70 FR... Disclosure Act (HMDA). 70 FR 12148 (Mar. 22, 2007). See 12 U.S.C. 2808; 12 CFR 203.2(e)(1). On March 22, 2007... federal banking agencies in its CRA rule set forth at 12 CFR 563e. 72 FR 13429. Pursuant to the...

  13. 25 CFR 273.54 - Privacy Act requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... system of records without prior approval of the Department of Interior and the Office of Management and... Privacy Act requirements. (a) When a contractor operates a system of records to accomplish a Bureau function, the contractor shall comply with subpart D of 43 CFR part 2 which implements the Privacy Act (5...

  14. 25 CFR 273.54 - Privacy Act requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... system of records without prior approval of the Department of Interior and the Office of Management and... Privacy Act requirements. (a) When a contractor operates a system of records to accomplish a Bureau function, the contractor shall comply with subpart D of 43 CFR part 2 which implements the Privacy Act (5...

  15. 25 CFR 273.54 - Privacy Act requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... system of records without prior approval of the Department of Interior and the Office of Management and... Privacy Act requirements. (a) When a contractor operates a system of records to accomplish a Bureau function, the contractor shall comply with subpart D of 43 CFR part 2 which implements the Privacy Act (5...

  16. 25 CFR 273.54 - Privacy Act requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... system of records without prior approval of the Department of Interior and the Office of Management and... Privacy Act requirements. (a) When a contractor operates a system of records to accomplish a Bureau function, the contractor shall comply with subpart D of 43 CFR part 2 which implements the Privacy Act (5...

  17. 25 CFR 273.54 - Privacy Act requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... function, the contractor shall comply with subpart D of 43 CFR part 2 which implements the Privacy Act (5 U.... 43 CFR 2.56 lists exceptions to this procedure. (4) To establish a procedure to account for access... 25 Indians 1 2010-04-01 2010-04-01 false Privacy Act requirements. 273.54 Section 273.54...

  18. Regulations which require employee training: An overview

    SciTech Connect

    Gilfus, L.J.

    1995-11-01

    In order to identify the Occupational Safety and Health Administration (OSHA) regulations which apply to a certain plant or facility, one needs to find the reference materials that are needed and that can be trusted. An overview is presented of the following: Title 29 -- Labor, OSHA Training Requirements; Title 40, Environmental Protection Agency Training Requirements; and Title 49, Department of Transportation Training Regulations.

  19. 78 FR 54648 - Federal Acquisition Regulation; Information Collection; American Recovery and Reinvestment Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-05

    ... Regulation; Information Collection; American Recovery and Reinvestment Act--Reporting Requirements--One-Time... identified by Information Collection 9000- 0168, American Recovery and Reinvestment Act--Reporting..., company name (if any), and ``Information Collection 9000-0168, American Recovery and Reinvestment...

  20. 78 FR 54650 - Federal Acquisition Regulation; Information Collection American Recovery and Reinvestment Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-05

    ... Regulation; Information Collection American Recovery and Reinvestment Act-Reporting Requirements--One-Time... comments identified by Information Collection 9000- 0167, American Recovery and Reinvestment Act-Reporting.... Instructions: Please submit comments only and cite Information Collection 9000-0167, American Recovery...

  1. 78 FR 39901 - Amendments to the 2013 Mortgage Rules Under the Equal Credit Opportunity Act (Regulation B), Real...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ... purposes under the mortgage regulations, application of the loan originator compensation rules to bank... Bureau issued Escrow Requirements Under the Truth in Lending Act (Regulation Z), 78 FR 4726 (Jan. 30... Settlement Procedures Act (Regulation X), 78 FR 6856 (Jan. 31, 2013) (2013 HOEPA Final Rule), and Ability...

  2. Brightening up: the effect of the Physician Payment Sunshine Act on existing regulation of pharmaceutical marketing.

    PubMed

    Gorlach, Igor; Pham-Kanter, Genevieve

    2013-01-01

    With the passage of the Physician Payment Sunshine Act as part of the federal health care reform law, pharmaceutical manufacturers are now required to disclose a wide range of payments made by manufacturers to physicians. We review current state regulation of pharmaceutical marketing and consider how the federal sunshine provision will affect existing marketing regulation. We analyze the legal and practical implications of the Physician Payment Sunshine Act.

  3. Brightening up: the effect of the Physician Payment Sunshine Act on existing regulation of pharmaceutical marketing.

    PubMed

    Gorlach, Igor; Pham-Kanter, Genevieve

    2013-01-01

    With the passage of the Physician Payment Sunshine Act as part of the federal health care reform law, pharmaceutical manufacturers are now required to disclose a wide range of payments made by manufacturers to physicians. We review current state regulation of pharmaceutical marketing and consider how the federal sunshine provision will affect existing marketing regulation. We analyze the legal and practical implications of the Physician Payment Sunshine Act. PMID:23581674

  4. 77 FR 75362 - Government in the Sunshine Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-20

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY COMMISSION 29 CFR Part 1612 Government in the Sunshine Act Regulations CFR Correction 0 In Title 29 of the Code of Federal Regulations, Parts 900 to 1899, revised as of July 1, 2012, on page 266, in Sec....

  5. MAPPING GASOLINE REQUIREMENTS, APPLICABLE REGULATIONS AND BANS

    EPA Science Inventory

    Federal and State regulations play an important role in understanding gasoline composition around the United States. Multiple sources of information on these programs were used to develop reliable, up-to-date maps showing gasoline requirements imposed by various regulations. Th...

  6. 2 CFR 176.190 - Award term-Wage rate requirements under Section 1606 of the Recovery Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... THAT INCLUDE FUNDS UNDER THE AMERICAN RECOVERY AND REINVESTMENT ACT OF 2009, PUBLIC LAW 111-5 Wage Rate... rate requirements under Section 1606 of the Recovery Act. When issuing announcements or requesting... Copeland Act, 40 U.S.C. 3145, the Department of Labor has issued regulations at 29 CFR parts 1, 3, and 5...

  7. 75 FR 58390 - Federal Acquisition Regulation; Information Collection; American Recovery and Reinvestment Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-24

    ... Regulation; Information Collection; American Recovery and Reinvestment Act-Reporting Requirements--One-Time... extension of a currently approved information collection requirement concerning the American Recovery and... particularly invited on: Whether this collection of information is necessary for the proper performance...

  8. 30 CFR 252.6 - Freedom of Information Act requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Continental Shelf) and 30 CFR part 251 (Geological and Geophysical Explorations of the Outer Continental Shelf... Section 252.6 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT.... 552), the regulations contained in 43 CFR part 2 (Records and Testimony), the requirements of the...

  9. 40 CFR 62.14480 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act and...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... an operating permit under title V of the Clean Air Act and implementing regulations? 62.14480 Section... the Clean Air Act and implementing regulations? This subpart requires you to obtain an operating permit under title V of the Clean Air Act and implementing regulations (“title V permit”) unless you...

  10. 40 CFR 62.14480 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act and...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... an operating permit under title V of the Clean Air Act and implementing regulations? 62.14480 Section... the Clean Air Act and implementing regulations? This subpart requires you to obtain an operating permit under title V of the Clean Air Act and implementing regulations (“title V permit”) unless you...

  11. HIPAA Mental Health Parity Act--IRS. Notice of proposed rulemaking by cross-reference to temporary regulations.

    PubMed

    1997-12-22

    Elsewhere in this issue of the Federal Register, the IRS is issuing temporary regulations relating to mental health parity requirements imposed on group health plans. These requirements were added to the Internal Revenue Code by section 1532 of the Taxpayer Relief Act of 1997. The IRS is issuing the temporary regulations at the same time that the Pension and Welfare Benefits Administration of the U.S. Department of Labor and the Health Care Financing Administration of the U.S. Department of Health and Human Services are issuing substantially similar interim final regulations relating to mental health parity requirements added by the Mental Health Parity Act of 1996 to the Employee Retirement Income Security Act of 1974 and the Public Health Service Act. The temporary regulations provide guidance to employers and group health plans relating to the new mental health parity requirements. The text of those temporary regulations also serves as the text of these proposed regulations.

  12. 29 CFR 785.5 - General requirements of sections 6 and 7 of the Fair Labor Standards Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the Fair Labor Standards Act. Section 6 requires the payment of a minimum wage by an employer to his... 29 Labor 3 2013-07-01 2013-07-01 false General requirements of sections 6 and 7 of the Fair Labor Standards Act. 785.5 Section 785.5 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR...

  13. 29 CFR 785.5 - General requirements of sections 6 and 7 of the Fair Labor Standards Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the Fair Labor Standards Act. Section 6 requires the payment of a minimum wage by an employer to his... 29 Labor 3 2012-07-01 2012-07-01 false General requirements of sections 6 and 7 of the Fair Labor Standards Act. 785.5 Section 785.5 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR...

  14. 29 CFR 785.5 - General requirements of sections 6 and 7 of the Fair Labor Standards Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the Fair Labor Standards Act. Section 6 requires the payment of a minimum wage by an employer to his... 29 Labor 3 2014-07-01 2014-07-01 false General requirements of sections 6 and 7 of the Fair Labor Standards Act. 785.5 Section 785.5 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR...

  15. 29 CFR 785.5 - General requirements of sections 6 and 7 of the Fair Labor Standards Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the Fair Labor Standards Act. Section 6 requires the payment of a minimum wage by an employer to his... 29 Labor 3 2010-07-01 2010-07-01 false General requirements of sections 6 and 7 of the Fair Labor Standards Act. 785.5 Section 785.5 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR...

  16. 29 CFR 785.5 - General requirements of sections 6 and 7 of the Fair Labor Standards Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the Fair Labor Standards Act. Section 6 requires the payment of a minimum wage by an employer to his... 29 Labor 3 2011-07-01 2011-07-01 false General requirements of sections 6 and 7 of the Fair Labor Standards Act. 785.5 Section 785.5 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR...

  17. 2 CFR 176.190 - Award term-Wage rate requirements under Section 1606 of the Recovery Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... RECOVERY AND REINVESTMENT ACT OF 2009, PUBLIC LAW 111-5 Wage Rate Requirements Under Section 1606 of the American Recovery and Reinvestment Act of 2009 § 176.190 Award term—Wage rate requirements under Section.... 3145, the Department of Labor has issued regulations at 29 CFR parts 1, 3, and 5 to implement the...

  18. 7 CFR 27.3 - Requirements of subsection 15b(f) of the Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Requirements of subsection 15b(f) of the Act. 27.3 Section 27.3 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND...

  19. 29 CFR 1977.3 - General requirements of section 11(c) of the Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false General requirements of section 11(c) of the Act. 1977.3 Section 1977.3 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) DISCRIMINATION AGAINST EMPLOYEES EXERCISING RIGHTS UNDER...

  20. 29 CFR 1977.3 - General requirements of section 11(c) of the Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 9 2011-07-01 2011-07-01 false General requirements of section 11(c) of the Act. 1977.3 Section 1977.3 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) DISCRIMINATION AGAINST EMPLOYEES EXERCISING RIGHTS UNDER...

  1. 29 CFR 1977.3 - General requirements of section 11(c) of the Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false General requirements of section 11(c) of the Act. 1977.3 Section 1977.3 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) DISCRIMINATION AGAINST EMPLOYEES EXERCISING RIGHTS UNDER...

  2. 29 CFR 1977.3 - General requirements of section 11(c) of the Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 9 2013-07-01 2013-07-01 false General requirements of section 11(c) of the Act. 1977.3 Section 1977.3 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) DISCRIMINATION AGAINST EMPLOYEES EXERCISING RIGHTS UNDER...

  3. 29 CFR 1977.3 - General requirements of section 11(c) of the Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 9 2012-07-01 2012-07-01 false General requirements of section 11(c) of the Act. 1977.3 Section 1977.3 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) DISCRIMINATION AGAINST EMPLOYEES EXERCISING RIGHTS UNDER...

  4. 48 CFR 52.225-10 - Notice of Buy American Act Requirement-Construction Materials.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Requirement-Construction Materials. 52.225-10 Section 52.225-10 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.225-10 Notice of Buy American Act Requirement—Construction Materials. As prescribed... Materials (FEB 2009) (a) Definitions. “Commercially available off-the-shelf (COTS) item,”...

  5. 48 CFR 52.225-10 - Notice of Buy American Act Requirement-Construction Materials.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Requirement-Construction Materials. 52.225-10 Section 52.225-10 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.225-10 Notice of Buy American Act Requirement—Construction Materials. As prescribed... Materials (FEB 2009) (a) Definitions. “Commercially available off-the-shelf (COTS) item,”...

  6. 48 CFR 52.225-10 - Notice of Buy American Act Requirement-Construction Materials.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Requirement-Construction Materials. 52.225-10 Section 52.225-10 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.225-10 Notice of Buy American Act Requirement—Construction Materials. As prescribed... Materials (FEB 2009) (a) Definitions. “Commercially available off-the-shelf (COTS) item,”...

  7. 48 CFR 52.225-10 - Notice of Buy American Act Requirement-Construction Materials.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Requirement-Construction Materials. 52.225-10 Section 52.225-10 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.225-10 Notice of Buy American Act Requirement—Construction Materials. As prescribed... Materials (FEB 2009) (a) Definitions. “Commercially available off-the-shelf (COTS) item,”...

  8. 30 CFR 552.6 - Freedom of Information Act requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) and 30 CFR part 551 (Geological and Geophysical Explorations of the Outer Continental Shelf). (b... Section 552.6 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE... contained in 43 CFR part 2 (Records and Testimony), the requirements of the Act, and the...

  9. 30 CFR 552.6 - Freedom of Information Act requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) and 30 CFR part 551 (Geological and Geophysical Explorations of the Outer Continental Shelf). (b... Section 552.6 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE... contained in 43 CFR part 2 (Records and Testimony), the requirements of the Act, and the...

  10. 30 CFR 552.6 - Freedom of Information Act requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) and 30 CFR part 551 (Geological and Geophysical Explorations of the Outer Continental Shelf). (b... Section 552.6 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE... contained in 43 CFR part 2 (Records and Testimony), the requirements of the Act, and the...

  11. 75 FR 41370 - Regulations Implementing the Freedom of Information Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-16

    ... amended. 75 FR 22320, Apr. 28, 2010. Interested persons were afforded an opportunity to participate in the... HEALTH REVIEW COMMISSION 29 CFR Part 2201 Regulations Implementing the Freedom of Information Act AGENCY: Occupational Safety and Health Review Commission. ACTION: Final rule. SUMMARY: The Occupational Safety...

  12. 76 FR 59071 - Freedom of Information Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-23

    ... follows: Authority: 50 U.S.C. 401-442; 50 U.S.C. 403a-403v; 5 U.S.C. 552; Executive Order 13392, 70 FR... From the Federal Register Online via the Government Publishing Office CENTRAL INTELLIGENCE AGENCY 32 CFR Part 1900 Freedom of Information Act Regulations AGENCY: Central Intelligence Agency....

  13. 76 FR 45403 - Bank Secrecy Act Regulations-Definitions and Other Regulations Relating to Prepaid Access

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-29

    ... regulations. See 75 FR 65806 (October 26, 2010) (Transfer and Reorganization of Bank Secrecy Act Regulations... Relating to Money Services Businesses, 74 FR 22129 (May 12, 2009), was issued before the Chapter X Final...), (c). \\16\\ 75 FR 36589. B. Prior Regulation of Stored Value In 1999, when FinCEN issued its final...

  14. NASA's Principal Center for Review of Clean Air Act Regulations

    NASA Technical Reports Server (NTRS)

    Clark-Ingram, Marceia

    2003-01-01

    Marshall Space Flight Center (MSFC) was selected as the Principal Center for review of Clean Air Act (CAA) regulations. The CAA Principal Center is tasked to: 1) Provide centralized support to NASA/HDQ Code JE for the management and leadership of NASA's CAA regulation review process; 2) Identify potential impact from proposed CAA regulations to NASA program hardware and supporting facilities. The Shuttle Environmental Assurance Initiative, one of the responsibilities of the NASA CAA Working Group (WG), is described in part of this viewgraph presentation.

  15. 75 FR 19241 - Financial Crimes Enforcement Network; Amendment to the Bank Secrecy Act Regulations; Defining...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-14

    ... for Mutual Funds, 67 FR 21117 (April 29, 2002); Customer Identification Programs for Mutual Funds, 68 FR 25131 (May 9, 2003); Amendment to the Bank Secrecy Act Regulations--Requirement That Mutual Funds Report Suspicious Activity, 71 FR 26213 (May 4, 2006); Anti-Money Laundering Programs; Special...

  16. Medical loss ratio regulation under the Affordable Care Act.

    PubMed

    Harrington, Scott E

    2013-01-01

    The minimum medical loss ratio (MLR) regulations in the Affordable Care Act guarantee that a specific percentage of health insurance premiums is spent on medical care and specified activities to improve health care quality. This paper analyzes the regulations' potential unintended consequences and incentive effects, including: higher medical costs and premiums for some insurers; less innovation to align consumer, provider, and health plan incentives, less consumer choice and increased market concentration; and the risk that insurers will pay rebates if claim costs are lower than projected when premiums are established, despite the regulations' permitted "credibility adjustments." The paper discusses modifications and alternatives to the MLR regulations to help achieve their stated goals with less potential for adverse effects. PMID:23720876

  17. General requirements for RCRA regulated hazardous waste tanks

    SciTech Connect

    1995-11-01

    The Resource Conservation and Recovery Act (RCRA), as amended, requires that tanks used for the storage or treatment of hazardous waste (HazW) be permitted, and comply with the requirements contained within the Code of Federal Regulations (CFR) TItle 40 in Subpart J of Part 264/265, unless those tanks have been exempted. Subpart J specifies requirements for the design, construction, installation, operation, inspection, maintenance, repair, release, response, and closure of HazW tanks. Also, the regulations make a distinction between new and existing tanks. Effective December 6, 1995, standards for controlling volatile organic air emissions will apply to non-exempt HazW tanks. HazW tanks will have to be equipped with a cover or floating roof, or be designed to operate as a closed system, to be in compliance with the air emission control requirements. This information brief describes those tanks that are subject to the Subpart J requirements, and will also discuss secondary containment, inspection, restrictions on waste storage, release response, and closure requirements associated with regulated HazW tanks.

  18. 77 FR 57043 - Regulations Under the Fur Products Labeling Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ... Labeling Act (``TFLA''), and, on its own initiative, deleting unnecessary requirements. \\1\\ 76 FR 13550..., most recently in 1967.\\17\\ \\16\\ 15 U.S.C. 69e(b). \\17\\ 32 FR 6023 (Apr. 15, 1967). C. TFLA In 2010....ftc.gov/opa/2011/07/regreview.shtm . \\24\\ 76 FR 13550. \\25\\ The comments, along with a transcript...

  19. 2 CFR 176.190 - Award term-Wage rate requirements under Section 1606 of the Recovery Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... FUNDS UNDER THE AMERICAN RECOVERY AND REINVESTMENT ACT OF 2009, PUBLIC LAW 111-5 Wage Rate Requirements Under Section 1606 of the American Recovery and Reinvestment Act of 2009 § 176.190 Award term—Wage rate....S.C. 3145, the Department of Labor has issued regulations at 29 CFR parts 1, 3, and 5 to...

  20. 2 CFR 176.190 - Award term-Wage rate requirements under Section 1606 of the Recovery Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... FUNDS UNDER THE AMERICAN RECOVERY AND REINVESTMENT ACT OF 2009, PUBLIC LAW 111-5 Wage Rate Requirements Under Section 1606 of the American Recovery and Reinvestment Act of 2009 § 176.190 Award term—Wage rate....S.C. 3145, the Department of Labor has issued regulations at 29 CFR parts 1, 3, and 5 to...

  1. 77 FR 74347 - Freedom of Information Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-14

    ... Information Act (FOIA) (U.S.C. 552) in the Federal Register. See 77 FR 42673, July 20, 2012. CIGIE provided..., Regulatory Planning and Review, 58 FR 51735. This regulation has not been reviewed by the Office of.... Authority: Pub. L. 110-409, 122 Stat. 4302; 5 U.S.C. App; E.O. 12600, 52 FR 23781, 3 CFR, 1987 Comp., p....

  2. 76 FR 71707 - Revising Underground Storage Tank Regulations-Revisions to Existing Requirements and New...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-18

    ...EPA is proposing to make certain revisions to the 1988 underground storage tank (UST) technical, financial responsibility, and state program approval regulations. These changes establish federal requirements that are similar to key portions of the Energy Policy Act of 2005; they also update certain 1988 UST regulations. Proposed changes include: Adding secondary containment requirements for......

  3. 76 FR 35963 - Disclosure of Information; Privacy Act Regulations; Notice and Amendments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-21

    ... CORPORATION 12 CFR Parts 309 and 310 RIN 3064-AD83 Disclosure of Information; Privacy Act Regulations; Notice... for comments. SUMMARY: The Dodd-Frank Wall Street Reform and Consumer Protection Act (Act), abolished... Freedom of Information Act (FOIA) and Privacy Act (PA) regulations will not be enforced by the FDIC...

  4. Additional requirements for charitable hospitals; community health needs assessments for charitable hospitals; requirement of a section 4959 excise tax return and time for filing the return. Final regulations and removal of temporary regulations.

    PubMed

    2014-12-31

    This document contains final regulations that provide guidance regarding the requirements for charitable hospital organizations added by the Patient Protection and Affordable Care Act of 2010. The regulations will affect charitable hospital organizations PMID:25562896

  5. Additional requirements for charitable hospitals; community health needs assessments for charitable hospitals; requirement of a section 4959 excise tax return and time for filing the return. Final regulations and removal of temporary regulations.

    PubMed

    2014-12-31

    This document contains final regulations that provide guidance regarding the requirements for charitable hospital organizations added by the Patient Protection and Affordable Care Act of 2010. The regulations will affect charitable hospital organizations

  6. 76 FR 68027 - Federal Acquisition Regulation; Certification Requirement and Procurement Prohibition Relating to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ... RIN 9000-AL71 Federal Acquisition Regulation; Certification Requirement and Procurement Prohibition... Sanctions Act of 1996 (the Iran Sanctions Act). Section 106 imposes a procurement prohibition relating to..., Procurement Analyst, at (202) 219-0202, for clarification of content. For information pertaining to status...

  7. Safe drinking water act: Amendments, regulations and standards

    SciTech Connect

    Calabrese, E.J.; Gilbert, C.E.; Pastides, H.

    1989-01-01

    This book approaches the topic of safe drinking water by communicating how the EPA has responded to the mandates of Congress. Chapter 1 summarizes what is and will be involved in achieving safe drinking water. Chapter 2 describes the historical development of drinking water regulations. Chapter 3 summarizes the directives of the Safe Drinking Water Act Amendments of 1986. Chapters 4 through 9 discuss each phase of the regulatory program in turn. Specific problems associated with volatile organic chemicals, synthetic organics, inorganic chemicals, and microbiological contaminants are assessed in Chapter 4 and 5. The unique characteristics of radionuclides and their regulation are treated in Chapter 6. The disinfection process and its resultant disinfection by-products are presented in Chapter 7. The contaminant selection process and the additional contaminants to be regulated by 1989 and 1991 and in future years are discussed in Chapters 8 and 9. EPA's Office of Drinking Water's Health Advisory Program is explained in Chapter 10. The record of public water system compliance with the primary drinking water regulations is detailed in Chapter 11. Chapter 12 offers a nongovernmental perspective on the general quality of drinking water and how this is affected by a wide range of drinking water treatment technologies. Separate abstracts are processed for 5 chapters in this book for inclusion in the appropriate data bases.

  8. 7 CFR 800.7 - Information about the Service, Act, and regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Information about the Service, Act, and regulations... AGRICULTURE GENERAL REGULATIONS Administration § 800.7 Information about the Service, Act, and regulations. Information about the Grain Inspection, Packers and Stockyards Administration, Service, Act,...

  9. Regulations Under the Americans With Disabilities Act; Genetic Information Nondiscrimination Act. Final rule.

    PubMed

    2016-05-17

    The Equal Employment Opportunity Commission (EEOC or Commission) is issuing its final rule to amend the regulations and interpretive guidance implementing Title I of the Americans with Disabilities Act (ADA) to provide guidance on the extent to which employers may use incentives to encourage employees to participate in wellness programs that ask them to respond to disability-related inquiries and/or undergo medical examinations. This rule applies to all wellness programs that include disability-related inquiries and/or medical examinations whether they are offered only to employees enrolled in an employer-sponsored group health plan, offered to all employees regardless of whether they are enrolled in such a plan, or offered as a benefit of employment by employers that do not sponsor a group health plan or group health insurance. Published elsewhere in this issue of the Federal Register, the EEOC also issued a final rule to amend the regulations implementing Title II of the Genetic Information Nondiscrimination Act (GINA) that addresses the extent to which employers may offer incentives for an employee's spouse to participate in a wellness program. PMID:27192736

  10. Regulations Under the Americans With Disabilities Act; Genetic Information Nondiscrimination Act. Final rule.

    PubMed

    2016-05-17

    The Equal Employment Opportunity Commission (EEOC or Commission) is issuing its final rule to amend the regulations and interpretive guidance implementing Title I of the Americans with Disabilities Act (ADA) to provide guidance on the extent to which employers may use incentives to encourage employees to participate in wellness programs that ask them to respond to disability-related inquiries and/or undergo medical examinations. This rule applies to all wellness programs that include disability-related inquiries and/or medical examinations whether they are offered only to employees enrolled in an employer-sponsored group health plan, offered to all employees regardless of whether they are enrolled in such a plan, or offered as a benefit of employment by employers that do not sponsor a group health plan or group health insurance. Published elsewhere in this issue of the Federal Register, the EEOC also issued a final rule to amend the regulations implementing Title II of the Genetic Information Nondiscrimination Act (GINA) that addresses the extent to which employers may offer incentives for an employee's spouse to participate in a wellness program.

  11. Adaptive Equilibrium Regulation: A Balancing Act in Two Timescales

    PubMed Central

    Boker, Steven M.

    2015-01-01

    An equilibrium involves a balancing of forces. Just as one maintains upright posture in standing or walking, many self-regulatory and interpersonal behaviors can be framed as a balancing act between an ever changing environment and within-person processes. The emerging balance between person and environment, the equilibria, are dynamic and adaptive in response to development and learning. A distinction is made between equilibrium achieved solely due to a short timescale balancing of forces and a longer timescale preferred equilibrium which we define as a state towards which the system slowly adapts. Together, these are developed into a framework that this article calls Adaptive Equilibrium Regulation (ÆR), which separates a regulatory process into two timescales: a faster regulation that automatically balances forces and a slower timescale adaptation process that reconfigures the fast regulation so as to move the system towards its preferred equilibrium when an environmental force persists over the longer timescale. This way of thinking leads to novel models for the interplay between multiple timescales of behavior, learning, and development. PMID:27066197

  12. Actin is required for IFT regulation in Chlamydomonas reinhardtii.

    PubMed

    Avasthi, Prachee; Onishi, Masayuki; Karpiak, Joel; Yamamoto, Ryosuke; Mackinder, Luke; Jonikas, Martin C; Sale, Winfield S; Shoichet, Brian; Pringle, John R; Marshall, Wallace F

    2014-09-01

    Assembly of cilia and flagella requires intraflagellar transport (IFT), a highly regulated kinesin-based transport system that moves cargo from the basal body to the tip of flagella [1]. The recruitment of IFT components to basal bodies is a function of flagellar length, with increased recruitment in rapidly growing short flagella [2]. The molecular pathways regulating IFT are largely a mystery. Because actin network disruption leads to changes in ciliary length and number, actin has been proposed to have a role in ciliary assembly. However, the mechanisms involved are unknown. In Chlamydomonas reinhardtii, conventional actin is found in both the cell body and the inner dynein arm complexes within flagella [3, 4]. Previous work showed that treating Chlamydomonas cells with the actin-depolymerizing compound cytochalasin D resulted in reversible flagellar shortening [5], but how actin is related to flagellar length or assembly remains unknown. Here we utilize small-molecule inhibitors and genetic mutants to analyze the role of actin dynamics in flagellar assembly in Chlamydomonas reinhardtii. We demonstrate that actin plays a role in IFT recruitment to basal bodies during flagellar elongation and that when actin is perturbed, the normal dependence of IFT recruitment on flagellar length is lost. We also find that actin is required for sufficient entry of IFT material into flagella during assembly. These same effects are recapitulated with a myosin inhibitor, suggesting that actin may act via myosin in a pathway by which flagellar assembly is regulated by flagellar length.

  13. 20 CFR 652.211 - What are State planning requirements under the Act?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... of services provided under the Act in accordance with WIA regulations at 20 CFR 661.220. The State..., DEPARTMENT OF LABOR ESTABLISHMENT AND FUNCTIONING OF STATE EMPLOYMENT SERVICES Wagner-Peyser Act Services...

  14. 20 CFR 652.211 - What are State planning requirements under the Act?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... of services provided under the Act in accordance with WIA regulations at 20 CFR 661.220. The State..., DEPARTMENT OF LABOR ESTABLISHMENT AND FUNCTIONING OF STATE EMPLOYMENT SERVICES Wagner-Peyser Act Services...

  15. Ninety-day waiting period limitation and technical amendments to certain health coverage requirements under the Affordable Care Act. Final rule.

    PubMed

    2014-02-24

    These final regulations implement the 90-day waiting period limitation under section 2708 of the Public Health Service Act, as added by the Patient Protection and Affordable Care Act (Affordable Care Act), as amended, and incorporated into the Employee Retirement Income Security Act of 1974 and the Internal Revenue Code. These regulations also finalize amendments to existing regulations to conform to Affordable Care Act provisions. Specifically, these rules amend regulations implementing existing provisions such as some of the portability provisions added by the Health Insurance Portability and Accountability Act of 1996 (HIPAA) because those provisions of the HIPAA regulations have become superseded or require amendment as a result of the market reform protections added by the Affordable Care Act.

  16. Maintaining Student Records and Meeting Confidentiality Requirements under the Family Education Rights and Privacy Act (FERPA), Individuals with Disability Education Act (IDEA), Section 504 of the Rehabilitation Act (504). A Primer for Educators

    ERIC Educational Resources Information Center

    Copenhaver, John

    2006-01-01

    An important federal statute impacting student records is the Family Educational Rights and Privacy Act (FERPA), enacted to ensure student/parent access to education records and to limit disclosures to others for unauthorized purposes. FERPA Regulations set forth the basic federal records retention and destruction requirements. The records of…

  17. The Americans with Disabilities Act and Family and Medical Leave Act: Legal Requirements, Negotiations and Policy Considerations.

    ERIC Educational Resources Information Center

    Juengart, Laurie S.

    The Americans with Disabilities Act (ADA) and Family and Medical Leave Act (FMLA) are two major pieces of social legislation that impact private and public employers, including school districts. Public school employers must have thorough awareness of the legal requirements of both laws and must analyze the ways in which those requirements…

  18. 7 CFR 868.10 - Information about the Service, Act, and regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Information about the Service, Act, and regulations... § 868.10 Information about the Service, Act, and regulations. Information about the Service, Act... INSPECTION, PACKERS AND STOCKYARD ADMINISTRATION (FEDERAL GRAIN INSPECTION SERVICE), DEPARTMENT...

  19. 77 FR 57199 - 2012 Real Estate Settlement Procedures Act (Regulation X) Mortgage Servicing Proposal

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ...The Bureau of Consumer Financial Protection (the Bureau) is proposing to amend Regulation X, which implements the Real Estate Settlement Procedures Act of 1974 (RESPA) and the official interpretation of the regulation. The proposed amendments implement the Dodd-Frank Wall Street Reform and Consumer Protection Act (Dodd-Frank Act) provisions regarding mortgage loan servicing. Specifically, this......

  20. HIPAA Newborns' and Mothers' Health Protection Act--IRS. Notice of proposed rulemaking by cross-reference to temporary regulations.

    PubMed

    1998-10-27

    Elsewhere in this issue of the Federal Register, the IRS is issuing temporary regulations relating to minimum hospital length-of-stay requirements imposed on group health plans with respect to mothers and newborns. The hospital length-of-stay requirements were added to the Internal Revenue Code by section 1531 of the Taxpayer Relief Act of 1997. The IRS is issuing the temporary regulations at the same time that the Pension and Welfare Benefits Administration of the U.S. Department of Labor and the Health Care Financing Administration of the U.S. Department of Health and Human Services are issuing substantially similar interim final regulations relating to hospital length-of-stay requirements added by the Newborns' and Mothers' Health Protection Act of 1996 to the Employee Retirement Income Security Act of 1974 and the Public Health Service Act. The temporary regulations provide guidance to employers and group health plans relating to the new hospital length-of-stay requirements. The text of those temporary regulations also serves as the text of these proposed regulations.

  1. Free Appropriate Public Education for Students with Disabilities: Requirements under Section 504 of the "Rehabilitation Act of 1973." Revised

    ERIC Educational Resources Information Center

    US Department of Education, 2007

    2007-01-01

    Section 504 of the "Rehabilitation Act of 1973" protects the rights of individuals with disabilities in programs and activities that receive federal funds. The Section 504 regulation requires a school district to provide a "free appropriate public education" (FAPE) to each qualified person with a disability who is in the school district's…

  2. Implementation of the Methamphetamine Anti-Proliferation Act; thresholds for retailers and for distributors required to submit mail order reports; changes to mail order reporting requirements. Final rule.

    PubMed

    2003-10-01

    This regulation implements the new threshold requirements and mail order reporting requirements of the Methamphetamine Anti-Proliferation Act of 2000 (MAPA), which was enacted on October 17, 2000. DEA is amending its regulations to reduce the thresholds for pseudoephedrine and phenylpropanolamine for retail distributors and for distributors required to submit mail order reports. Also, DEA is amending its regulations to require mail order reports for certain export transactions. DEA is codifying exemptions from the mail order reporting requirements for certain distributions to nonregulated persons and certain export transactions. This rule is consistent with the intent of MAPA to prevent the diversion of drug products to the clandestine manufacture of methamphetamine and amphetamine, and simultaneously reduce the industry reporting burden. PMID:14535265

  3. Requirements and impacts of the Federal Facility Compliance Act on the Department of Energy

    SciTech Connect

    Chang, L.; Tripp, S.C.

    1993-03-01

    The Federal Facilities Compliance Act (FFCA, the Act) was signed into law on October 6, 1992, primarily as a means of waiving sovereign immunity for federal facilities with respect to requirements under the Resource Conservation and Recovery Act. DOE`s implementation of the FFCA will have significant effects on current and future DOE waste management operations. DOE will need to rethink its strategy in the area of future compliance agreements to ensure commitments and deliverables are made consistent throughout the different DOE facilities. Several types of agreements that address mixed waste land disposal restriction (LDR) compliance have already been signed by both DOE and the regulators. These agreements are in place at the Hanford Reservation, the Savannah River Site, the Oak Ridge Reservation (Oak Ridge National Laboratory, K-25, Y-12), and the Paducah Gaseous Diffusion Plant. The Rocky Flats Agreement is now being renegotiated. Los Alamos National Laboratory, Sandia/Albuquerque National Laboratory, Lawrence Livermore National Laboratory, and Idaho National Engineering Laboratory agreements are in progress. Major components of the FFCA include provisions on: sovereign immunity waiver; cost reimbursements; mixed waste requirements, including inventory reports on mixed waste and treatment capacity and technologies; and plans for the development of treatment capacities and technologies. Each of these components is discussed within this paper.

  4. Implementing the Affordable Care Act: Revisiting the ACA's Essential Health Benefits Requirements.

    PubMed

    Giovannelli, Justin; Lucia, Kevin W; Corlette, Sabrina

    2014-10-01

    The Affordable Care Act broadens and strengthens the health insurance benefits available to consumers by requiring insurers to provide coverage of a minimum set of medical services known as "essential health benefits." Federal officials implemented this reform using transitional policies that left many important decisions to the states, while pledging to reassess that approach in time for the 2016 coverage year. This issue brief examines how states have exercised their options under the initial federal essential health benefits framework. We find significant variation in how states have developed their essential health benefits packages, including their approaches to benefit substitution and coverage of habilitative services. Federal regulators should use insurance company data describing enrollees' experiences with their coverage--information called for under the law's delayed transparency requirements--to determine whether states' differing strategies are producing the coverage improvements promised by reform. PMID:26259257

  5. 47 CFR 80.163 - Operator requirements of the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Operator requirements of the Bridge-to-Bridge... Requirements § 80.163 Operator requirements of the Bridge-to-Bridge Act. Each ship subject to the Bridge-to-Bridge Act must have on board a radio operator who holds a restricted radiotelephone operator permit...

  6. 47 CFR 80.163 - Operator requirements of the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Operator requirements of the Bridge-to-Bridge... Requirements § 80.163 Operator requirements of the Bridge-to-Bridge Act. Each ship subject to the Bridge-to-Bridge Act must have on board a radio operator who holds a restricted radiotelephone operator permit...

  7. 47 CFR 80.163 - Operator requirements of the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Operator requirements of the Bridge-to-Bridge... Requirements § 80.163 Operator requirements of the Bridge-to-Bridge Act. Each ship subject to the Bridge-to-Bridge Act must have on board a radio operator who holds a restricted radiotelephone operator permit...

  8. 47 CFR 80.163 - Operator requirements of the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Operator requirements of the Bridge-to-Bridge... Requirements § 80.163 Operator requirements of the Bridge-to-Bridge Act. Each ship subject to the Bridge-to-Bridge Act must have on board a radio operator who holds a restricted radiotelephone operator permit...

  9. 47 CFR 80.163 - Operator requirements of the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Operator requirements of the Bridge-to-Bridge... Requirements § 80.163 Operator requirements of the Bridge-to-Bridge Act. Each ship subject to the Bridge-to-Bridge Act must have on board a radio operator who holds a restricted radiotelephone operator permit...

  10. 47 CFR 80.305 - Watch requirements of the Communications Act and the Safety Convention.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Watch requirements of the Communications Act... (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Safety Watch Requirements and Procedures Ship Station Safety Watches § 80.305 Watch requirements of the Communications Act and the...

  11. 47 CFR 80.305 - Watch requirements of the Communications Act and the Safety Convention.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Watch requirements of the Communications Act... (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Safety Watch Requirements and Procedures Ship Station Safety Watches § 80.305 Watch requirements of the Communications Act and the...

  12. 47 CFR 80.305 - Watch requirements of the Communications Act and the Safety Convention.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Watch requirements of the Communications Act... (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Safety Watch Requirements and Procedures Ship Station Safety Watches § 80.305 Watch requirements of the Communications Act and the...

  13. 47 CFR 80.305 - Watch requirements of the Communications Act and the Safety Convention.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Watch requirements of the Communications Act... (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Safety Watch Requirements and Procedures Ship Station Safety Watches § 80.305 Watch requirements of the Communications Act and the...

  14. 47 CFR 80.309 - Watch required by the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Watch required by the Bridge-to-Bridge Act. 80... Safety Watches § 80.309 Watch required by the Bridge-to-Bridge Act. In addition to the watch requirement contained in § 80.148, all vessels subject to the Bridge-to-Bridge Act must keep a watch on the...

  15. 47 CFR 80.309 - Watch required by the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Watch required by the Bridge-to-Bridge Act. 80... Safety Watches § 80.309 Watch required by the Bridge-to-Bridge Act. In addition to the watch requirement contained in § 80.148, all vessels subject to the Bridge-to-Bridge Act must keep a watch on the...

  16. 47 CFR 80.309 - Watch required by the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Watch required by the Bridge-to-Bridge Act. 80... Safety Watches § 80.309 Watch required by the Bridge-to-Bridge Act. In addition to the watch requirement contained in § 80.148, all vessels subject to the Bridge-to-Bridge Act must keep a watch on the...

  17. 47 CFR 80.309 - Watch required by the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Watch required by the Bridge-to-Bridge Act. 80... Safety Watches § 80.309 Watch required by the Bridge-to-Bridge Act. In addition to the watch requirement contained in § 80.148, all vessels subject to the Bridge-to-Bridge Act must keep a watch on the...

  18. 47 CFR 80.309 - Watch required by the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Watch required by the Bridge-to-Bridge Act. 80... Safety Watches § 80.309 Watch required by the Bridge-to-Bridge Act. In addition to the watch requirement contained in § 80.148, all vessels subject to the Bridge-to-Bridge Act must keep a watch on the...

  19. 77 FR 51784 - Federal Acquisition Regulation; Information Collection; Qualification Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-27

    ... minutes per submission assuming an offeror's use of electronic information tracking and retrieval... Regulation; Information Collection; Qualification Requirements AGENCY: Department of Defense (DOD), General... reinstatement request for an information collection requirement regarding an existing OMB clearance....

  20. 9 CFR 331.3 - States designated under paragraph 301(c) of the Act; application of regulations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...(c) of the Act; application of regulations. 331.3 Section 331.3 Animals and Animal Products FOOD... circuit supervisor (showing any modifications required by the circuit supervisor) to the Labels and Packaging Staff, Meat and Poultry Inspection, Food Safety and Inspection Service, USDA, Washington, DC...

  1. 9 CFR 381.222 - States designated under paragraph 5(c) of the Act; application of regulations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) of the Act; application of regulations. 381.222 Section 381.222 Animals and Animal Products FOOD... modifications required by the Circuit Supervisor) to the Labels and Packaging Staff, Meat and Poultry Inspection Food Safety and Inspection Service, U.S. Department of Agriculture, Washington, DC 20250,...

  2. 9 CFR 331.3 - States designated under paragraph 301(c) of the Act; application of regulations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...(c) of the Act; application of regulations. 331.3 Section 331.3 Animals and Animal Products FOOD... circuit supervisor (showing any modifications required by the circuit supervisor) to the Labels and Packaging Staff, Meat and Poultry Inspection, Food Safety and Inspection Service, USDA, Washington, DC...

  3. Federal Interagency Day Care Requirements, Pursuant to Sec. 522 (D) of the Economic Opportunity Act.

    ERIC Educational Resources Information Center

    Department of Health, Education, and Welfare, Washington, DC.

    This document defines federal interagency requirements which day care programs must meet if they are receiving funds under any of the following programs: Title IV (parts A and B) of the Social Security Act; Title I, Title II, Title III (Part B), and Title V (Part B) of the Economic Opportunity Act; the Manpower Development and Training Act; and…

  4. 77 FR 34927 - National Pollutant Discharge Elimination System-Proposed Regulations To Establish Requirements...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-12

    ... under section 316(b) of the Clean Water Act (CWA), at 76 FR 22174. EPA received voluminous comments and... on closed cycle cooling'' (76 FR 22174, Section VI.E). The four factors have not changed on the basis...--Proposed Regulations To Establish Requirements for Cooling Water Intake Structures at Existing...

  5. RCRA, Superfund and EPCRA hotline training module. Introduction to: Oil Pollution Prevention Regulation and the Oil Pollution Act of 1990 (updated February 1998); Directive

    SciTech Connect

    1998-06-01

    The goal of this module is to explain the purpose, scope, and reporting requirements under the Spill Prevention Control and Countermeasures (SPCC) and related regulations and the Oil Pollution Act of 1990.

  6. 78 FR 20291 - Fisheries of the United States; Billfish Conservation Act of 2012 Implementing Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-04

    .... SUPPLEMENTARY INFORMATION: Background The Billfish Conservation Act of 2012 (BCA), Public Law 112-183, 16 U.S.C... States; Billfish Conservation Act of 2012 Implementing Regulations AGENCY: National Marine Fisheries... the implementation of the Billfish Conservation Act of 2012. DATES: Written comments regarding...

  7. 75 FR 14547 - Tribal Consultation on Draft Buy Indian Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-26

    ... Bureau of Indian Affairs 48 CFR Chapter 14 RIN 1076-AE95 Tribal Consultation on Draft Buy Indian Act... comments concerning draft regulations to implement the Buy Indian Act. See the SUPPLEMENTARY INFORMATION... implementation of the Buy Indian Act, 25 U.S.C. 47, which provides authority to set aside procurement...

  8. 78 FR 70515 - Petition To Promulgate Standards for Bears Under the Animal Welfare Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-26

    ... Standards for Bears Under the Animal Welfare Act Regulations AGENCY: Animal and Plant Health Inspection... Health Inspection Service has received a petition requesting that we amend the Animal Welfare Act..., Riverdale, MD 20737-1234; (301) 851-3751. SUPPLEMENTARY INFORMATION: Background The Animal Welfare Act...

  9. 76 FR 68690 - Rules and Regulations Under the Textile Fiber Products Identification Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ... Wool Products Labeling Act, and the Fur Products Labeling Act: Final Rule, 63 FR 7508 (Feb. 13, 1998). \\2\\ Federal Trade Commission: Miscellaneous Rules: Final Rule, 63 FR 71582 (Dec. 29, 1998). \\3... and Regulations Under the Wool Products Labeling Act of 1939, Final Rule, 65 FR 75154 (Dec. 1,...

  10. 78 FR 29263 - Rules andRegulations Under the Textile Fiber Products Identification Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-20

    ... Under the Textile Fiber Products Identification Act, 76 FR 68690 (Nov. 7, 2011). This Notice of Proposed...--Rules and Regulations Under the Textile Fiber Products Identification Act, 24 FR 4480, 4485 (June 2... Rulemaking, 50 FR 15100 at 15101 (Apr. 15, 1985). This Notice compared the Customs regulations in 19 CFR...

  11. 78 FR 41835 - Inflation Adjustments to the Price-Anderson Act Financial Protection Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-12

    ... made the initial changes to the Price-Anderson Act amounts on October 27, 2005 (70 FR 61885), and the... Federal Regulations is sold by the Superintendent of Documents. #0;Prices of new books are listed in the... 3150-AJ25 Inflation Adjustments to the Price-Anderson Act Financial Protection Regulations...

  12. 5 CFR 293.202 - Records subject to Office or agency Privacy Act regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Privacy Act regulations. 293.202 Section 293.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT... Records subject to Office or agency Privacy Act regulations. When the Office of Personnel Management publishes in the Federal Register a notice of system of records for personnel records which are...

  13. 75 FR 75692 - Manufactured Home Construction and Safety Standards Act Reporting Requirements; Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-06

    ... URBAN DEVELOPMENT Manufactured Home Construction and Safety Standards Act Reporting Requirements; Notice.... This Notice also lists the following information: Title of Proposal: Manufactured Home Construction and Safety Standards Reporting Requirements. OMB Control Number, if applicable: 2502-0253. Description of...

  14. Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly

    PubMed Central

    Lettice, Laura A.; Horikoshi, Taizo; Heaney, Simon J. H.; van Baren, Marijke J.; van der Linde, Herma C.; Breedveld, Guido J.; Joosse, Marijke; Akarsu, Nurten; Oostra, Ben A.; Endo, Naoto; Shibata, Minoru; Suzuki, Mikio; Takahashi, Eiichi; Shinka, Toshikatsu; Nakahori, Yutaka; Ayusawa, Dai; Nakabayashi, Kazuhiko; Scherer, Stephen W.; Heutink, Peter; Hill, Robert E.; Noji, Sumihare

    2002-01-01

    Preaxial polydactyly (PPD) is a common limb malformation in human. A number of polydactylous mouse mutants indicate that misexpression of Shh is a common requirement for generating extra digits. Here we identify a translocation breakpoint in a PPD patient and a transgenic insertion site in the polydactylous mouse mutant sasquatch (Ssq). The genetic lesions in both lie within the same respective intron of the LMBR1/Lmbr1 gene, which resides ≈1 Mb away from Shh. Genetic analysis of Ssq reveals that the Lmbr1 gene is incidental to the phenotype and that the mutation directly interrupts a cis-acting regulator of Shh. This regulator is most likely the target for generating PPD mutations in human. PMID:12032320

  15. Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly.

    PubMed

    Lettice, Laura A; Horikoshi, Taizo; Heaney, Simon J H; van Baren, Marijke J; van der Linde, Herma C; Breedveld, Guido J; Joosse, Marijke; Akarsu, Nurten; Oostra, Ben A; Endo, Naoto; Shibata, Minoru; Suzuki, Mikio; Takahashi, Eiichi; Shinka, Toshikatsu; Nakahori, Yutaka; Ayusawa, Dai; Nakabayashi, Kazuhiko; Scherer, Stephen W; Heutink, Peter; Hill, Robert E; Noji, Sumihare

    2002-05-28

    Preaxial polydactyly (PPD) is a common limb malformation in human. A number of polydactylous mouse mutants indicate that misexpression of Shh is a common requirement for generating extra digits. Here we identify a translocation breakpoint in a PPD patient and a transgenic insertion site in the polydactylous mouse mutant sasquatch (Ssq). The genetic lesions in both lie within the same respective intron of the LMBR1/Lmbr1 gene, which resides approximately 1 Mb away from Shh. Genetic analysis of Ssq reveals that the Lmbr1 gene is incidental to the phenotype and that the mutation directly interrupts a cis-acting regulator of Shh. This regulator is most likely the target for generating PPD mutations in human.

  16. 12 CFR 335.601 - Requirements of section 16 of the Securities Exchange Act of 1934.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... regulations issued under section 16 of the Exchange Act (17 CFR part 240), except that the forms described in... FDICconnect at https://www2.fdicconnect.gov/index.asp. Copies of FDIC Forms 3, 4, and 5 and the...

  17. 12 CFR 335.601 - Requirements of section 16 of the Securities Exchange Act of 1934.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... regulations issued under section 16 of the Exchange Act (17 CFR part 240), except that the forms described in... FDICconnect at https://www2.fdicconnect.gov/index.asp. Copies of FDIC Forms 3, 4, and 5 and the...

  18. 12 CFR 335.601 - Requirements of section 16 of the Securities Exchange Act of 1934.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... regulations issued under section 16 of the Exchange Act (17 CFR part 240), except that the forms described in... FDICconnect at https://www2.fdicconnect.gov/index.asp. Copies of FDIC Forms 3, 4, and 5 and the...

  19. 12 CFR 335.601 - Requirements of section 16 of the Securities Exchange Act of 1934.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... regulations issued under section 16 of the Exchange Act (17 CFR part 240), except that the forms described in... FDICconnect at https://www2.fdicconnect.gov/index.asp. Copies of FDIC Forms 3, 4, and 5 and the...

  20. 45 CFR 73.735-901 - Reporting requirement of the Ethics in Government Act of 1978.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Reporting requirement of the Ethics in Government... requirement of the Ethics in Government Act of 1978. (a) Applicability. The following employees and special... Title II of the Ethics in Government Act of 1978, Pub. L. 95-521, as amended: (1) Officers and...

  1. 45 CFR 73.735-901 - Reporting requirement of the Ethics in Government Act of 1978.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Reporting requirement of the Ethics in Government... requirement of the Ethics in Government Act of 1978. (a) Applicability. The following employees and special... Title II of the Ethics in Government Act of 1978, Pub. L. 95-521, as amended: (1) Officers and...

  2. 77 FR 13617 - Agency Information Collection Activities: Customs Modernization Act Recordkeeping Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-07

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Customs Modernization Act Recordkeeping Requirements AGENCY: U.S. Customs and Border Protection (CBP), Department of... concerning the Customs Modernization Act Recordkeeping Requirements. This request for comment is being...

  3. 45 CFR 73.735-901 - Reporting requirement of the Ethics in Government Act of 1978.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Reporting requirement of the Ethics in Government... requirement of the Ethics in Government Act of 1978. (a) Applicability. The following employees and special... Title II of the Ethics in Government Act of 1978, Pub. L. 95-521, as amended: (1) Officers and...

  4. 45 CFR 73.735-901 - Reporting requirement of the Ethics in Government Act of 1978.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Reporting requirement of the Ethics in Government... requirement of the Ethics in Government Act of 1978. (a) Applicability. The following employees and special... Title II of the Ethics in Government Act of 1978, Pub. L. 95-521, as amended: (1) Officers and...

  5. 5 CFR 1830.2 - Requirements for making Privacy Act requests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Requirements for making Privacy Act requests. 1830.2 Section 1830.2 Administrative Personnel OFFICE OF SPECIAL COUNSEL PRIVACY § 1830.2 Requirements for making Privacy Act requests. (a) How made and addressed. A request for OSC records under...

  6. 28 CFR 55.22 - Requirements of section 5 of the Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Requirements of section 5 of the Act. 55.22 Section 55.22 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) IMPLEMENTATION OF THE PROVISIONS OF THE VOTING RIGHTS ACT REGARDING LANGUAGE MINORITY GROUPS Preclearance § 55.22 Requirements...

  7. 28 CFR 55.22 - Requirements of section 5 of the Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Requirements of section 5 of the Act. 55.22 Section 55.22 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) IMPLEMENTATION OF THE PROVISIONS OF THE VOTING RIGHTS ACT REGARDING LANGUAGE MINORITY GROUPS Preclearance § 55.22 Requirements...

  8. 45 CFR 73.735-901 - Reporting requirement of the Ethics in Government Act of 1978.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Reporting requirement of the Ethics in Government Act of 1978. 73.735-901 Section 73.735-901 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... requirement of the Ethics in Government Act of 1978. (a) Applicability. The following employees and...

  9. 24 CFR 1000.42 - Are the requirements of section 3 of the Housing and Urban Development Act of 1968 applicable?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Development Act of 1968 (12 U.S.C. 1701u) and HUD's implementing regulations in 24 CFR part 135, to the... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Are the requirements of section 3 of the Housing and Urban Development Act of 1968 applicable? 1000.42 Section 1000.42 Housing...

  10. 24 CFR 1000.42 - Are the requirements of section 3 of the Housing and Urban Development Act of 1968 applicable?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Development Act of 1968 (12 U.S.C. 1701u) and HUD's implementing regulations in 24 CFR part 135, to the... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Are the requirements of section 3 of the Housing and Urban Development Act of 1968 applicable? 1000.42 Section 1000.42 Housing...

  11. MEETING THE REQUIREMENTS OF THE U.S. SAFE DRINKING WATER ACT: THE ROLE OF TECHNOLOGY

    EPA Science Inventory

    The passage of the U.S. Safe Drinking Water Act (SDWA) in 1974 has had a major impact on the way water is treated and delivered in the United States. The Act established national drinking water regulations for more than 170,000 public drinking water systems serving over 250 mill...

  12. Some impacts of the 1990 Clean Air Act and state clean-air regulations on the fertilizer industry

    SciTech Connect

    Breed, C.E.; Kerns, O.S.

    1992-12-31

    The Clean Air Act amendments of 1990 will intensify national efforts to reduce air pollution. They will have major impacts on governmental agencies and on industrial and commercial facilities throughout the country. As with other industries, it is essential for fertilizer dealers and producers to understand how these changes to the Clean Air Act can significantly change the way they do business. This paper is proffered as an overview of ways in which the 1990 amendments to the Clean Air Act may impact the fertilizer industry. The nonattainment, toxics, and permit provisions of the amended act will be three areas of particular concern to the fertilizer industry. Implementation of the new regulatory requirements of this legislation promises to be a long and onerous process for all concerned. However, it appears that state and local regulations may have a much more profound impact on the fertilizer industry than the new Clean Air Act.

  13. Some impacts of the 1990 Clean Air Act and state clean-air regulations on the fertilizer industry

    SciTech Connect

    Breed, C.E.; Kerns, O.S.

    1992-12-01

    The Clean Air Act amendments of 1990 will intensify national efforts to reduce air pollution. They will have major impacts an governmental agencies and on industrial and commercial facilities throughout the country. As with other industries, it is essential for fertilizer dealers and producers to understand how these changes to the Clean Air Act can significantly change the way they do business. This paper is proffered as an overview of ways in which the 1990 amendments to the Clean Air Act may impact the fertilizer industry. The nonattainment, toxics, and permit provisions of the amended act will be three areas of particular concern to the fertilizer industry. Implementation of the new regulatory requirements of this legislation promises to be a long and onerous process for all concerned. However, it appears that state and local regulations may have a much more profound impact on the fertilizer industry than the new Clean Air Act.

  14. Overview of the regulation of hazardous chemicals: SDWA (Safe Drinking Water Act), RCRA (Resource Conservation and Recovery Act), and CERCLA (Comprehensive Environmental Response, Compensation, and Liability Act)

    SciTech Connect

    Baes, C.F. III

    1989-01-01

    The regulation of nonradioactive hazardous chemicals is carried out under a number of federal environmental laws that regulate either hazardous products, substances, or wastes. Because each law is intended to provide protection from different classes of substances (e.g., wastes vs products) or protect different media (e.g., air, water, land), the standards and levels of protection for different hazardous chemicals may be different. Nevertheless, one agency -- the Environmental Protection Agency (EPA) -- has primary responsibility for both promulgating regulations mandated by Congress under the various statutes and enforcement of the regulations. One overriding principal underlies the maze of complex regulations that govern the transport, treatment, storage, and disposal of hazardous substances: protect human health and the environment. It is beyond the scope of this talk to comprehensively examine all of the regulations and standards that govern the management of hazardous chemicals. Instead this discussion will focus on three statutes, the Safe Drinking Water Act (SDWA), the Resource Conservation and Recovery Act (RCRA), and the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), that together provide a basis for a basic understanding of the approach that the EPA takes to regulating hazardous chemicals.

  15. 77 FR 12754 - Contractor Legal Management Requirements; Acquisition Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-02

    ... Part 719 48 Parts 931, 952 and 970 RIN 1990-AA37 Contractor Legal Management Requirements; Acquisition... covering contractor legal management requirements and make conforming amendments to the Department of... rulemaking to revise existing regulations covering contractor legal management requirements and...

  16. 78 FR 54252 - Information Collection; American Recovery and Reinvestment Act-Reporting Requirements-One Time...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-03

    ... FR 58389, for the number of respondents required to comply with the requirements of FAR subpart 4.15... Register on September 24, 2010, at 75 FR 58389. No public comments were received in prior years that have...; American Recovery and Reinvestment Act-- Reporting Requirements--One Time Reporting Requirements for...

  17. 77 FR 50390 - Equal Credit Opportunity Act (Regulation B)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-21

    ..., such as account numbers or social security numbers, should not be included. Comments will not be edited... from the Bureau's rulemaking authority by section 1029 of the Dodd-Frank Act). 76 FR 79442 (Dec. 21...-reference to the definition of ``dwelling'' that, as discussed below, is proposed to be moved to Sec....

  18. 75 FR 22320 - Regulations Implementing the Freedom of Information Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-28

    ... From the Federal Register Online via the Government Publishing Office OCCUPATIONAL SAFETY AND... Government Act), as well as changes in OSHRC's own policies and procedures. DATES: Submit comments on or before May 28, 2010. ADDRESSES: OSHRC encourages electronic submission of comments. You may...

  19. 77 FR 66539 - Freedom of Information Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-06

    ... electronic records and automated searches along with paper records and manual searches. In addition, FMCS's... twenty cents per page, while document search and review charges will increase to $4.00 per each quarter... revisions read as follows: Sec. 1401.36 Freedom of Information Act fee schedules. (a) * * * (2) Search...

  20. 78 FR 50351 - Freedom of Information Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ... without charge. These Direct Costs shall include the cost of operating a central processing unit for that... processing Requests for Information under the Freedom of Information Act (FOIA). The revisions reorganize the... reached before the NCPC charges members of the public a processing fee for information. DATES:...

  1. 78 FR 32595 - Revision of Freedom of Information Act Regulation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ..., entitled ``Freedom of Information Act'' (74 FR 4683, January 26, 2009) and ``Transparency and Openness'' (74 FR 4685, January 26, 2009), which encourage federal agencies to apply a presumption of disclosure... published by the Department of Justice (DOJ) on March 21, 2011 (76 FR 15236). DOJ intended for these...

  2. The Equal Access Act: Policy and Regulations for Implementation.

    ERIC Educational Resources Information Center

    Jones, H. Lawrence; Martin, James

    The Equal Access Act of 1984 was drafted to implement access for religious clubs to public secondary schools, but with constitutionally protected safeguards to preclude entanglement of church and state. A number of challenges were made on the constitutional grounds of excessive entanglement of church and state, as well as what the definition of…

  3. 76 FR 15841 - General Rules and Regulations, Securities Act of 1933

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-22

    ... COMMISSION 17 CFR Part 230 General Rules and Regulations, Securities Act of 1933 CFR Correction In Title 17 of the Code of Federal Regulations, Parts 200 to 239, revised as of April 1, 2010, on page 686, in.... 230.501 Definitions and terms used in Regulation D. * * * * * (e) * * * NOTE: The issuer must...

  4. The Final Regulations to the Carl D. Perkins Vocational and Applied Technology Education Act of 1990.

    ERIC Educational Resources Information Center

    American Vocational Association, Alexandria, VA.

    This publication presents the final regulations to the Carl D. Perkins Vocational and Applied Technology Education Act of 1990. The first section is an analysis of the regulations. This analysis compares the proposed regulations to the final version and explains the differences between the two and the potential impact on program administration.…

  5. 78 FR 79729 - Integrated Mortgage Disclosures Under the Real Estate Settlement Procedures Act (Regulation X...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ...Sections 1098 and 1100A of the Dodd-Frank Wall Street Reform and Consumer Protection Act (Dodd-Frank Act) direct the Bureau to publish rules and forms that combine certain disclosures that consumers receive in connection with applying for and closing on a mortgage loan under the Truth in Lending Act and the Real Estate Settlement Procedures Act. Consistent with this requirement, the Bureau is......

  6. Melatonin is required for the circadian regulation of sleep.

    PubMed

    Gandhi, Avni V; Mosser, Eric A; Oikonomou, Grigorios; Prober, David A

    2015-03-18

    Sleep is an evolutionarily conserved behavioral state whose regulation is poorly understood. A classical model posits that sleep is regulated by homeostatic and circadian mechanisms. Several factors have been implicated in mediating the homeostatic regulation of sleep, but molecules underlying the circadian mechanism are unknown. Here we use animals lacking melatonin due to mutation of arylalkylamine N-acetyltransferase 2 (aanat2) to show that melatonin is required for circadian regulation of sleep in zebrafish. Sleep is dramatically reduced at night in aanat2 mutants maintained in light/dark conditions, and the circadian regulation of sleep is abolished in free-running conditions. We find that melatonin promotes sleep downstream of the circadian clock as it is not required to initiate or maintain circadian rhythms. Additionally, we provide evidence that melatonin may induce sleep in part by promoting adenosine signaling, thus potentially linking circadian and homeostatic control of sleep.

  7. Melatonin is required for the circadian regulation of sleep

    PubMed Central

    Gandhi, Avni V.; Mosser, Eric; Oikonomou, Grigorios; Prober, David A.

    2015-01-01

    Summary Sleep is an evolutionarily conserved behavioral state whose regulation is poorly understood. A classical model posits that sleep is regulated by homeostatic and circadian mechanisms. Several factors have been implicated in mediating the homeostatic regulation of sleep, but molecules underlying the circadian mechanism are unknown. Here we use animals lacking melatonin due to mutation of arylalkylamine N-acetyltransferase 2 (aanat2) to show that melatonin is required for circadian regulation of sleep in zebrafish. Sleep is dramatically reduced at night in aanat2 mutants maintained in light/dark conditions, and the circadian regulation of sleep is abolished in free-running conditions. We find that melatonin promotes sleep downstream of the circadian clock as it is not required to initiate or maintain circadian rhythms. Additionally, we provide evidence that melatonin may induce sleep in part by promoting adenosine signaling, thus potentially linking circadian and homeostatic control of sleep. PMID:25754820

  8. 32 CFR 505.14 - Recordkeeping requirements under the Privacy Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... under the Privacy Act. (a) AR 25-400-2, The Army Records Information Management System (ARIMS). To maintain privacy records are required by the Army Records Information Management System (ARIMS) to...

  9. 32 CFR 505.14 - Recordkeeping requirements under the Privacy Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... under the Privacy Act. (a) AR 25-400-2, The Army Records Information Management System (ARIMS). To maintain privacy records are required by the Army Records Information Management System (ARIMS) to...

  10. 32 CFR 505.14 - Recordkeeping requirements under the Privacy Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... under the Privacy Act. (a) AR 25-400-2, The Army Records Information Management System (ARIMS). To maintain privacy records are required by the Army Records Information Management System (ARIMS) to...

  11. 32 CFR 505.14 - Recordkeeping requirements under the Privacy Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... under the Privacy Act. (a) AR 25-400-2, The Army Records Information Management System (ARIMS). To maintain privacy records are required by the Army Records Information Management System (ARIMS) to...

  12. Employee Retirement Income Security Act of 1974: rules and regulations for administration and enforcement; claims procedure. Pension and Welfare Benefits Administration, Labor. Final regulation.

    PubMed

    2000-11-21

    This document contains a final regulation revising the minimum requirements for benefit claims procedures of employee benefit plans covered by Title I of the Employee Retirement Income Security Act of 1974 (ERISA or the Act). The regulation establishes new standards for the processing of claims under group health plans and plans providing disability benefits and further clarifies existing standards for all other employee benefit plans. The new standards are intended to ensure more timely benefit determinations, to improve access to information on which a benefit determination is made, and to assure that participants and beneficiaries will be afforded a full and fair review of denied claims. When effective, the regulation will affect participants and beneficiaries of employee benefit plans, employers who sponsor employee benefit plans, plan fiduciaries, and others who assist in the provision of plan benefits, such as third-party benefits administrators and health service providers or health maintenance organizations that provide benefits to participants and beneficiaries of employee benefit plans.

  13. Auxin acts independently of DELLA proteins in regulating gibberellin levels.

    PubMed

    Reid, James B; Davidson, Sandra E; Ross, John J

    2011-03-01

    Shoot elongation is a vital process for plant development and productivity, in both ecological and economic contexts. Auxin and bioactive gibberellins (GAs), such as GA1, play critical roles in the control of elongation, along with environmental and endogenous factors, including other hormones such as the brassinosteroids. The effect of auxins, such as indole-3-acetic acid (IAA), is at least in part mediated by its effect on GA metabolism, since auxin up-regulates biosynthesis genes such as GA 3-oxidase and GA 20-oxidase and down regulates GA catabolism genes such as GA 2-oxidases, leading to elevated levels of bioactive GA 1. In our recent paper, we have provided evidence that this action of IAA is largely independent of DELLA proteins, the negative regulators of GA action, since the auxin effects are still present in the DELLA-deficient la cry-s genotype of pea. This was a crucial issue to resolve, since like auxin, the DELLAs also promote GA 1 synthesis and inhibit its deactivation. DELLAs are deactivated by GA, and thereby mediate a feedback system by which bioactive GA regulates its own level. However, our recent results, in themselves, do not show the generality of the auxin-GA relationship across species and phylogenetic groups or across different tissue types and responses. Further, they do not touch on the ecological benefits of the auxin-GA interaction. These issues are discussed below as well as the need for the development of suitable experimental systems to allow this process to be examined. PMID:21358281

  14. The Fair Labor Standards Act and the Child Care Industry--What Regulations Apply.

    ERIC Educational Resources Information Center

    Lee, Elisa

    1996-01-01

    Discusses how the federal Fair Labor Standard Act (FLSA) affects the wages and work hours of child care employees and how FLSA interacts with analogous state laws. Examines how child care centers can determine whether FLSA regulations apply to them, existing exemptions to the current act, minimum wage and overtime, whether training time is working…

  15. 20 CFR 626.2 - Format of the Job Training Partnership Act regulations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., including complaint processing and compliance reviews, will be governed by the provisions of 29 CFR part 34... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Format of the Job Training Partnership Act... LABOR INTRODUCTION TO THE REGULATIONS UNDER THE JOB TRAINING PARTNERSHIP ACT § 626.2 Format of the...

  16. 20 CFR 626.2 - Format of the Job Training Partnership Act regulations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., including complaint processing and compliance reviews, will be governed by the provisions of 29 CFR part 34... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Format of the Job Training Partnership Act... LABOR INTRODUCTION TO THE REGULATIONS UNDER THE JOB TRAINING PARTNERSHIP ACT § 626.2 Format of the...

  17. 20 CFR 626.4 - Table of contents for the Job Training Partnership Act regulations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the Job Training Partnership Act, 20 CFR parts 626-638 and 1005, 1 is as follows: 1 Part 1005 was... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Table of contents for the Job Training..., DEPARTMENT OF LABOR INTRODUCTION TO THE REGULATIONS UNDER THE JOB TRAINING PARTNERSHIP ACT § 626.4 Table...

  18. 20 CFR 626.4 - Table of contents for the Job Training Partnership Act regulations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... the Job Training Partnership Act, 20 CFR parts 626-638 and 1005, 1 is as follows: 1 Part 1005 was... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Table of contents for the Job Training..., DEPARTMENT OF LABOR INTRODUCTION TO THE REGULATIONS UNDER THE JOB TRAINING PARTNERSHIP ACT § 626.4 Table...

  19. 76 FR 40367 - Federal Acquisition Regulation; Information Collection; Buy American Act-Construction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-08

    ... (Grimberg Decision). Public comments are particularly invited on: Whether this collection of information is..., American Act--Construction (Grimberg Decision), by any of the following methods: ] Regulations.gov : http... Collection 9000-0141,'' American Act--Construction (Grimberg Decision), under the heading ``Enter Keyword...

  20. atonal regulates neurite arborization but does not act as a proneural gene in the Drosophila brain

    NASA Technical Reports Server (NTRS)

    Hassan, B. A.; Bermingham, N. A.; He, Y.; Sun, Y.; Jan, Y. N.; Zoghbi, H. Y.; Bellen, H. J.

    2000-01-01

    Drosophila atonal (ato) is the proneural gene of the chordotonal organs (CHOs) in the peripheral nervous system (PNS) and the larval and adult photoreceptor organs. Here, we show that ato is expressed at multiple stages during the development of a lineage of central brain neurons that innervate the optic lobes and are required for eclosion. A novel fate mapping approach shows that ato is expressed in the embryonic precursors of these neurons and that its expression is reactivated in third instar larvae (L3). In contrast to its function in the PNS, ato does not act as a proneural gene in the embryonic brain. Instead, ato performs a novel function, regulating arborization during larval and pupal development by interacting with Notch.

  1. 40 CFR 62.14480 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act and...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Permitting Obligation § 62.14480 Does this subpart require me to obtain an operating permit under title V of... 40 Protection of Environment 9 2013-07-01 2013-07-01 false Does this subpart require me to obtain an operating permit under title V of the Clean Air Act and implementing regulations? 62.14480...

  2. 40 CFR 62.14480 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act and...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Permitting Obligation § 62.14480 Does this subpart require me to obtain an operating permit under title V of... 40 Protection of Environment 9 2014-07-01 2014-07-01 false Does this subpart require me to obtain an operating permit under title V of the Clean Air Act and implementing regulations? 62.14480...

  3. 40 CFR 62.14480 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act and...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Permitting Obligation § 62.14480 Does this subpart require me to obtain an operating permit under title V of... 40 Protection of Environment 9 2012-07-01 2012-07-01 false Does this subpart require me to obtain an operating permit under title V of the Clean Air Act and implementing regulations? 62.14480...

  4. 41 CFR 301-10.137 - What exceptions to the Fly America Act requirements apply when I travel solely outside the United...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... or more; or (b) Extend your travel time by 6 hours or more; or (c) Require a connecting time of 4... Fly America Act requirements apply when I travel solely outside the United States, and a U.S. flag air... Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL...

  5. 41 CFR 301-10.137 - What exceptions to the Fly America Act requirements apply when I travel solely outside the United...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... or more; or (b) Extend your travel time by 6 hours or more; or (c) Require a connecting time of 4... Fly America Act requirements apply when I travel solely outside the United States, and a U.S. flag air... Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL...

  6. Polycomb Group Protein Pcgf6 Acts as a Master Regulator to Maintain Embryonic Stem Cell Identity

    PubMed Central

    Yang, Chao-Shun; Chang, Kung-Yen; Dang, Jason; Rana, Tariq M.

    2016-01-01

    The polycomb repressive complex 1 (PRC1) is a multi-subunit complex that plays critical roles in the epigenetic modulation of gene expression. Here, we show that the PRC1 component polycomb group ring finger 6 (Pcgf6) is required to maintain embryonic stem cell (ESC) identity. In contrast to canonical PRC1, Pcgf6 acts as a positive regulator of transcription and binds predominantly to promoters bearing active chromatin marks. Pcgf6 is expressed at high levels in ESCs, and knockdown reduces the expression of the core ESC regulators Oct4, Sox2, and Nanog. Conversely, Pcgf6 overexpression prevents downregulation of these factors and impairs differentiation. In addition, Pcgf6 enhanced reprogramming in both mouse and human somatic cells. The genomic binding profile of Pcgf6 is highly similar to that of trithorax group proteins, but not of PRC1 or PRC2 complexes, suggesting that Pcgf6 functions atypically in ESCs. Our data reveal novel roles for Pcgf6 in directly regulating Oct4, Nanog, Sox2, and Lin28 expression to maintain ESC identity. PMID:27247273

  7. A novel cis-acting element required for DNA damage-inducible expression of yeast DIN7

    SciTech Connect

    Yoshitani, Ayako; Yoshida, Minoru; Ling Feng

    2008-01-04

    Din7 is a DNA damage-inducible mitochondrial nuclease that modulates the stability of mitochondrial DNA (mtDNA) in Saccharomyces cerevisiae. How DIN7 gene expression is regulated, however, has remained largely unclear. Using promoter sequence alignment, we found a highly conserved 19-bp sequence in the promoter regions of DIN7 and NTG1, which encodes an oxidative stress-inducible base-excision-repair enzyme. Deletion of the 19-bp sequence markedly reduced the hydroxyurea (HU)-enhanced DIN7 promoter activity. In addition, nuclear fractions prepared from HU-treated cells were used in in vitro band shift assays to reveal the presence of currently unidentified trans-acting factor(s) that preferentially bound to the 19-bp region. These results suggest that the 19-bp sequence is a novel cis-acting element that is required for the regulation of DIN7 expression in response to HU-induced DNA damage.

  8. 77 FR 56592 - Freedom of Information Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-13

    ...--Based on GS-6, Step 5, pay (all employees at GS-7 and below are classified as clerical for this purpose); (2) Professional--Based on GS-11, Step 7, pay (all employees at GS- 8 through GS-12 are classified as... between the Federal and state governments. A Federalism Assessment is not required. 7. Civil...

  9. 77 FR 76898 - Freedom of Information Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-31

    ... reducing fees, for example, whenever ``the interest of the United States Government would be served.'' The... Final Rule Should Require the Department to State the Precise Volume of Denied Material and Provide a Detailed Justification of Its Withholdings One commenter suggested Sec. 2.24 be amended to state...

  10. 8 CFR 103.42 - Rules relating to the Freedom of Information Act (FOIA) and the Privacy Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Privacy Act. Immigration-related regulations relating to FOIA and the Privacy Act are located in 6 CFR... HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION BENEFITS; BIOMETRIC REQUIREMENTS; AVAILABILITY...

  11. 8 CFR 103.42 - Rules relating to the Freedom of Information Act (FOIA) and the Privacy Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Privacy Act. Immigration-related regulations relating to FOIA and the Privacy Act are located in 6 CFR... HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION BENEFITS; BIOMETRIC REQUIREMENTS; AVAILABILITY...

  12. 8 CFR 103.42 - Rules relating to the Freedom of Information Act (FOIA) and the Privacy Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Privacy Act. Immigration-related regulations relating to FOIA and the Privacy Act are located in 6 CFR... HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION BENEFITS; BIOMETRIC REQUIREMENTS; AVAILABILITY...

  13. 77 FR 38717 - Updating Regulations Issued Under the Fair Labor Standards Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Wage and Hour Division 29 CFR Parts 531 and 553 Updating Regulations Issued Under the Fair Labor Standards Act CFR Correction In Title 29 of the Code of Federal Regulations, Parts 500 to 899, revised as of July...

  14. 7 CFR 27.4 - Obligations and rights under Act: not affected by regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Obligations and rights under Act: not affected by regulations. 27.4 Section 27.4 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS...

  15. 7 CFR 27.95 - Spot markets to conform to Act and regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Spot markets to conform to Act and regulations. 27.95 Section 27.95 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND...

  16. 40 CFR 261.8 - PCB wastes regulated under Toxic Substance Control Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false PCB wastes regulated under Toxic... (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE General § 261.8 PCB wastes regulated under Toxic Substance Control Act. The disposal of PCB-containing dielectric fluid and...

  17. 40 CFR 261.8 - PCB wastes regulated under Toxic Substance Control Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false PCB wastes regulated under Toxic... (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE General § 261.8 PCB wastes regulated under Toxic Substance Control Act. The disposal of PCB-containing dielectric fluid and...

  18. 40 CFR 261.8 - PCB wastes regulated under Toxic Substance Control Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 26 2014-07-01 2014-07-01 false PCB wastes regulated under Toxic... (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE General § 261.8 PCB wastes regulated under Toxic Substance Control Act. The disposal of PCB-containing dielectric fluid and...

  19. 40 CFR 261.8 - PCB wastes regulated under Toxic Substance Control Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false PCB wastes regulated under Toxic... (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE General § 261.8 PCB wastes regulated under Toxic Substance Control Act. The disposal of PCB-containing dielectric fluid and...

  20. 40 CFR 261.8 - PCB wastes regulated under Toxic Substance Control Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false PCB wastes regulated under Toxic... (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE General § 261.8 PCB wastes regulated under Toxic Substance Control Act. The disposal of PCB-containing dielectric fluid and...

  1. 76 FR 78130 - Mortgage Acts and Practices-Advertising (Regulation N); Mortgage Assistance Relief Services...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ... the Bureau, the Bureau is publishing for public comment an interim final rule establishing a new Regulation N (Mortgage Acts and Practices-- Advertising Rule) and a new Regulation O (Mortgage Assistance Relief Services Rule). This interim final rule does not impose any new substantive obligations on...

  2. 75 FR 59609 - Rescission of Regulations Under the Comprehensive Smokeless Tobacco Health Education Act of 1986

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-28

    ... its smokeless tobacco regulations, 16 CFR Part 307, on November 4, 1986.\\1\\ 51 FR 40015. \\1\\ The... on utilitarian items. 56 FR 11654 (Mar. 20, 1991). II. Basis for Removal of Regulations On June 22... the enactment of the Family Smoking Prevention Act. 75 FR 3665 (Jan. 22, ] 2010). The...

  3. 78 FR 8963 - Update of Existing Privacy Act-NASA Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-07

    ... document contains corrections to the final regulations (NASA-2012-0005), which were published in the Federal Register of Thursday, October 4, 2012 (77 FR 60620). The regulations relate to requests to access... SPACE ADMINISTRATION 14 CFR Part 1212 RIN 2700-AD86 Update of Existing Privacy Act--NASA...

  4. A Safety and Health Guide for Vocational Educators. Incorporating Requirements of the Occupational Safety and Health Act of 1970, Relevant Pennsylvania Requirements with Particular Emphasis for Those Concerned with Cooperative Education and Work Study Programs. Volume 15. Number 1.

    ERIC Educational Resources Information Center

    Wahl, Ray

    Intended as a guide for vocational educators to incorporate the requirements of the Occupational Safety and Health Act (1970) and the requirements of various Pennsylvania safety and health regulations with their cooperative vocational programs, the first chapter of this document presents the legal implications of these safety and health…

  5. 75 FR 53153 - Federal Acquisition Regulation; American Recovery and Reinvestment Act of 2009 (the Recovery Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ... Federal Register at 74 FR 14623, March 31, 2009. The public comment period ended June 1, 2009. As required... Register at 73 FR 43385, July 25, 2008). Tariff shift rules consider the Harmonized Tariff Schedule of the... domestic manufactured construction material'' (see Federal Register at 74 FR 14624, March 31, 2009)....

  6. 21 CFR 21.71 - Disclosure of records in Privacy Act Record Systems; accounting required.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Systems; accounting required. 21.71 Section 21.71 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT... Record Systems; accounting required. (a) Except as provided in § 21.70, a record about an individual that... of the disclosure. The accounting shall not be considered a Privacy Act Record System. (2) Retain...

  7. 24 CFR 5.212 - Compliance with the Privacy Act and other requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Compliance with the Privacy Act and other requirements. 5.212 Section 5.212 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development GENERAL HUD PROGRAM REQUIREMENTS; WAIVERS Disclosure...

  8. 7 CFR 3575.40 - Equal opportunity and Fair Housing Act requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Marketing Plan and compliance with the Housing and Urban Development accessibility guidelines except for... Federal Reserve Board Regulation, 12 CFR part 202.) (b) Fair Housing Act. Certain housing-related projects... seq.). The lender will determine that the borrower has a valid plan in effect at all times....

  9. 40 CFR 63.312 - Existing regulations and requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... National Emission Standards for Coke Oven Batteries § 63.312 Existing regulations and requirements. (a) The..., topside port lids, coke oven doors, and charging operations in effect on September 15, 1992, or which have... method of monitoring in effect on September 15, 1992, and that ensures coke oven emission...

  10. 40 CFR 63.312 - Existing regulations and requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... National Emission Standards for Coke Oven Batteries § 63.312 Existing regulations and requirements. (a) The..., topside port lids, coke oven doors, and charging operations in effect on September 15, 1992, or which have... method of monitoring in effect on September 15, 1992, and that ensures coke oven emission...

  11. 40 CFR 63.312 - Existing regulations and requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... National Emission Standards for Coke Oven Batteries § 63.312 Existing regulations and requirements. (a) The..., topside port lids, coke oven doors, and charging operations in effect on September 15, 1992, or which have... method of monitoring in effect on September 15, 1992, and that ensures coke oven emission...

  12. 40 CFR 63.312 - Existing regulations and requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for Coke Oven Batteries § 63.312 Existing regulations and requirements. (a) The owner or operator shall comply with all applicable State implementation plan emission limits...

  13. 40 CFR 63.312 - Existing regulations and requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for Coke Oven Batteries § 63.312 Existing regulations and requirements. (a) The owner or operator shall comply with all applicable State implementation plan emission limits...

  14. 78 FR 29247 - Contractor Legal Management Requirements; Acquisition Regulations; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-20

    ..., on May 14, 2013. Paul Bosco, Director, Office of Acquisition and Project Management. BILLING CODE... Part 952 RIN 1990-AA37 Contractor Legal Management Requirements; Acquisition Regulations; Correction... correcting a final rule that appeared in the Federal Register of May 3, 2013 (78 FR 25795). In this...

  15. 75 FR 38684 - Federal Acquisition Regulation; FAR Case 2010-008, Recovery Act Subcontract Reporting Procedures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-02

    ... (DoD), General Services Administration (GSA), and National Aeronautics and Space Administration (NASA... 2009-009 in the Federal Register, (74 FR 14639) as an interim rule amending the FAR to implement section 1512 of the Recovery Act, which requires contractors to report on their use of Recovery Act...

  16. 76 FR 43585 - Bank Secrecy Act Regulations; Definitions and Other Regulations Relating to Money Services...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-21

    ... 31 of the Code of Federal Regulations for the BSA regulations. See 75 FR 65806 (October 26, 2010... Proposed Rulemaking, Definitions and Other Regulations Relating to Money Services Businesses, 74 FR 22129... financing of terrorist activities; \\7\\ (2) file Currency Transaction Reports (``CTRs'') \\8\\ and...

  17. Drinking water regulations under the Safe Drinking Water Act. Fact sheet

    SciTech Connect

    Not Available

    1990-12-01

    The fact sheet describes the requirements covered under the 1986 amendments to the Safe Drinking Water Act. Levels of various contaminants (including radio nuclides) are explained. Also discussed are the Surface Water Treatment Rule and the Total Coliforms Rule.

  18. Regulations for the administration and enforcement of the Radiation Control for Health and Safety Act of 1968

    SciTech Connect

    Not Available

    1988-04-01

    The purpose of the Act is to protect the public from unnecessary exposure to radiation from electronic products, including ionizing, nonionizing, electromagnetic, or particulate radiation, or any sonic, infrasonic, or ultrasonic wave. The regulations in the publication cover general provisions, statements of policy and interpretation, radiation protection recommendations, recordkeeping and reporting requirements for manufacturers, dealers, and distributors; notification requirements for defects or failure to comply; repurchase, repairs, or replacement of electronic products; importation of products; and performance standards for television receivers, cathode ray tubes, diagnostic x-ray equipment, radiographic equipment, fluoroscopic equipment, computer aided tomography equipment, microwave ovens, laser products, sunlamps, ultraviolet lamps, mercury lamps, and ultrasonic therapy products.

  19. Allowance trading under the Clean Air Act: Who should regulate, and when?

    SciTech Connect

    Lock, R.

    1993-07-01

    The goal of this paper is to explore how compliance with the Clean Air Act Amendments of 1990 (CAAA), especially Title IV and emission trading under it, will affect the current relationship between state and federal regulation. It is difficult, with the limited experience we have had under Title IV, to be definitive about or to be a very strong advocate of too many policy positions. What may be most helpful at this point is to identify where the difficult issues in state/federal relations might arise; and then to explore ways in which tensions might be either avoided or resolved. One anticipated conclusion is that a traditional regulatory mindset could be very destructive if applied to this new area of oversight without due sensitivity to what Congress is trying to achieve in Title IV. That concern pervaded the early legislative debates; and it persists today. Title IV presents some unique challenges to state regulators and will require some creative solutions and fresh thinking if the goals of Congress are to be realized and the full benefits that allowance trading can offer are to be reaped by electricity consumers. In the ultimate analysis, Title IV amounts to a massive internalization of the external costs imposed on society by acid rain deposition. (This places in serious question the notion of additional externality {open_quotes}adders{close_quotes} for sulfur dioxide (SO{sub 2}) and nitrous oxide (NO{sub x}) at the state level for utility supply planning purposes.) The whole point of Title IV is to give those directly charged with compliance, namely power producers, the maximum flexibility to pursue least-cost compliance solutions. Perhaps the biggest single factor in how well they do this will be how state regulators respond to their compliance and allowance trading initiatives.

  20. 78 FR 17186 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement (DFARS...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-20

    ... Regulation Supplement (DFARS); Notification Requirements for Critical Safety Items AGENCY: Defense... Acquisition Regulation Supplement (DFARS), Notification Requirements for Critical Safety Items; OMB...

  1. 15 CFR 781.4 - U.S. Government requests for information needed to satisfy the requirements of the APR or the Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false U.S. Government requests for information needed to satisfy the requirements of the APR or the Act. 781.4 Section 781.4 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND...

  2. Primer for Maintaining Accurate Special Education Records and Meeting Confidentiality Requirements When Serving Children with Disabilities--Family Educational Rights and Privacy Act (FERPA).

    ERIC Educational Resources Information Center

    Copenhaver, John

    This manual is intended to provide schools with guidance in complying with federal laws and regulations regarding record keeping and confidentiality in their services to students with disabilities. Part 1 focuses on requirements of the Family Education Rights and Privacy Act (FERPA), which ensures student/parent access to education records and…

  3. 20 CFR 670.420 - Are there any special requirements for enrollment related to the Military Selective Service Act?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... enrollment related to the Military Selective Service Act? 670.420 Section 670.420 Employees' Benefits... there any special requirements for enrollment related to the Military Selective Service Act? (a) Yes... of the Military Selective Service Act (50 U.S.C. App. 451 et seq.) if required; and (b) When a...

  4. 20 CFR 670.420 - Are there any special requirements for enrollment related to the Military Selective Service Act?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... enrollment related to the Military Selective Service Act? 670.420 Section 670.420 Employees' Benefits....420 Are there any special requirements for enrollment related to the Military Selective Service Act... section 3 of the Military Selective Service Act (50 U.S.C. App. 451 et seq.) if required; and (b) When...

  5. 20 CFR 670.420 - Are there any special requirements for enrollment related to the Military Selective Service Act?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... enrollment related to the Military Selective Service Act? 670.420 Section 670.420 Employees' Benefits... there any special requirements for enrollment related to the Military Selective Service Act? (a) Yes... of the Military Selective Service Act (50 U.S.C. App. 451 et seq.) if required; and (b) When a...

  6. 20 CFR 670.420 - Are there any special requirements for enrollment related to the Military Selective Service Act?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... enrollment related to the Military Selective Service Act? 670.420 Section 670.420 Employees' Benefits....420 Are there any special requirements for enrollment related to the Military Selective Service Act... section 3 of the Military Selective Service Act (50 U.S.C. App. 451 et seq.) if required; and (b) When...

  7. 20 CFR 670.420 - Are there any special requirements for enrollment related to the Military Selective Service Act?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... enrollment related to the Military Selective Service Act? 670.420 Section 670.420 Employees' Benefits....420 Are there any special requirements for enrollment related to the Military Selective Service Act... section 3 of the Military Selective Service Act (50 U.S.C. App. 451 et seq.) if required; and (b) When...

  8. 18 CFR Appendix A to Part 380 - Minimum Filing Requirements for Environmental Reports Under the Natural Gas Act

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Requirements for Environmental Reports Under the Natural Gas Act A Appendix A to Part 380 Conservation of Power... Filing Requirements for Environmental Reports Under the Natural Gas Act Environmental Reports Under the Natural Gas Act. Resource Report 1—General Project Description 1. Provide a detailed description...

  9. 18 CFR Appendix A to Part 380 - Minimum Filing Requirements for Environmental Reports Under the Natural Gas Act

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Requirements for Environmental Reports Under the Natural Gas Act A Appendix A to Part 380 Conservation of Power... Filing Requirements for Environmental Reports Under the Natural Gas Act Environmental Reports Under the Natural Gas Act. Resource Report 1—General Project Description 1. Provide a detailed description...

  10. 2 CFR 176.50 - Award term-Reporting and registration requirements under section 1512 of the Recovery Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... Agencies are responsible for ensuring that their recipients report information required under the Recovery... Act) and to report on use of Recovery Act funds provided through this award. Information from these... requirements under section 1512 of the Recovery Act. 176.50 Section 176.50 Grants and Agreements OFFICE...

  11. 2 CFR 176.50 - Award term-Reporting and registration requirements under section 1512 of the Recovery Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... requirements under section 1512 of the Recovery Act. 176.50 Section 176.50 Grants and Agreements Office of... AMERICAN RECOVERY AND REINVESTMENT ACT OF 2009, PUBLIC LAW 111-5 Reporting and Registration Requirements Under Section 1512 of the American Recovery and Reinvestment Act of 2009 § 176.50 Award...

  12. 2 CFR 176.50 - Award term-Reporting and registration requirements under section 1512 of the Recovery Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... requirements under section 1512 of the Recovery Act. 176.50 Section 176.50 Grants and Agreements Office of... THE AMERICAN RECOVERY AND REINVESTMENT ACT OF 2009, PUBLIC LAW 111-5 Reporting and Registration Requirements Under Section 1512 of the American Recovery and Reinvestment Act of 2009 § 176.50 Award...

  13. EVALUATION OF A PROTOCOL FOR DRINKING WATER TREATMENT DATA REQUIRED BY THE FOOD QUALITY PROTECTION ACT

    EPA Science Inventory

    Under the Food Quality Protection Act (FQPA), the USEPA Office of Pesticide Programs (OPP) considers drinking water as a route for pesticide exposure in its human health risk assessments, and may require data on the fate of a pesticide in drinking water be supplied to OPP by the ...

  14. 77 FR 27787 - Agency Information Collection Activities: Customs Modernization Act Recordkeeping Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-11

    ... collection was previously published in the Federal Register (77 FR 13617) on March 7, 2012, allowing for a 60... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Customs Modernization Act Recordkeeping Requirements AGENCY: U.S. Customs and Border Protection, Department of...

  15. 47 CFR 20.15 - Requirements under Title II of the Communications Act.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CARRIER SERVICES COMMERCIAL MOBILE RADIO SERVICES § 20.15 Requirements under Title II of the Communications Act. (a) Commercial mobile radio services providers, to the extent applicable, must comply with... CFR part 68; and §§ 1.701-1.748, and 1.815 of this chapter, 47 CFR 1.701-1.748, 1.815. (b)...

  16. 47 CFR 20.15 - Requirements under Title II of the Communications Act.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... CARRIER SERVICES COMMERCIAL MOBILE SERVICES § 20.15 Requirements under Title II of the Communications Act. (a) Commercial mobile radio services providers, to the extent applicable, must comply with sections....C. 201, 202, 206, 207, 208, 209, 216, 217, 223, 225, 226, 227, 228; part 68 of this chapter, 47...

  17. 27 CFR 26.202 - Requirements of the Federal Alcohol Administration Act.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Requirements of the Federal Alcohol Administration Act. 26.202 Section 26.202 Alcohol, Tobacco Products and Firearms ALCOHOL... RICO AND THE VIRGIN ISLANDS Products Coming Into the United States From the Virgin Islands §...

  18. 32 CFR 635.3 - Special requirements of the Privacy Act of 1974.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... used. (c) Army law enforcement personnel performing official duties often require an individual's SSN... contained thereon (for example, the sponsor's SSN) may be used to verify and complete applicable sections of... advised of the provisions of the Privacy Act Statement when requested to disclose their SSN. (d)...

  19. 32 CFR 635.3 - Special requirements of the Privacy Act of 1974.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... used. (c) Army law enforcement personnel performing official duties often require an individual's SSN... contained thereon (for example, the sponsor's SSN) may be used to verify and complete applicable sections of... advised of the provisions of the Privacy Act Statement when requested to disclose their SSN. (d)...

  20. 32 CFR 635.3 - Special requirements of the Privacy Act of 1974.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... used. (c) Army law enforcement personnel performing official duties often require an individual's SSN... contained thereon (for example, the sponsor's SSN) may be used to verify and complete applicable sections of... advised of the provisions of the Privacy Act Statement when requested to disclose their SSN. (d)...

  1. 32 CFR 635.3 - Special requirements of the Privacy Act of 1974.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... used. (c) Army law enforcement personnel performing official duties often require an individual's SSN... contained thereon (for example, the sponsor's SSN) may be used to verify and complete applicable sections of... advised of the provisions of the Privacy Act Statement when requested to disclose their SSN. (d)...

  2. 32 CFR 635.3 - Special requirements of the Privacy Act of 1974.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... used. (c) Army law enforcement personnel performing official duties often require an individual's SSN... contained thereon (for example, the sponsor's SSN) may be used to verify and complete applicable sections of... advised of the provisions of the Privacy Act Statement when requested to disclose their SSN. (d)...

  3. 76 FR 33413 - Proposed Renewal Without Change; Comment Request; Nine Bank Secrecy Act Recordkeeping Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-08

    ... Financial Crimes Enforcement Network Proposed Renewal Without Change; Comment Request; Nine Bank Secrecy Act... be submitted to: Financial Crimes Enforcement Network, P.O. Box 39, Vienna, VA 22183, Attention: BSA... Requirements Comments.'' FOR FURTHER INFORMATION CONTACT: Financial Crimes Enforcement Network,...

  4. The Reasonable Accommodation Requirements of Section 504 of the Rehabilitation Act.

    ERIC Educational Resources Information Center

    Wenkart, Ronald D.

    1990-01-01

    The reasonable accommodation requirements of Section 504 of the Rehabilitation Act of 1973 have recently been applied to public schools. Among the rulings were the provision of a sign language interpreter to hearing-impaired parents and the allowance of a service dog onto a school campus. (MLF)

  5. 75 FR 55663 - Requirements for Federal Funding Accountability and Transparency Act Implementation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-14

    ... of State officials; 16 institutions of higher education and an association of research universities... required for Transparency Act reporting of subawards and executive compensation [75 FR 43165]. The Federal... institutions of higher education noted that the limitation in OMB Circular A-21 on recovery of indirect...

  6. 21 CFR 21.71 - Disclosure of records in Privacy Act Record Systems; accounting required.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Disclosure of records in Privacy Act Record Systems; accounting required. 21.71 Section 21.71 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT... Record Systems to Persons Other Than the Subject Individual § 21.71 Disclosure of records in Privacy...

  7. 21 CFR 21.71 - Disclosure of records in Privacy Act Record Systems; accounting required.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Disclosure of records in Privacy Act Record Systems; accounting required. 21.71 Section 21.71 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT... Record Systems to Persons Other Than the Subject Individual § 21.71 Disclosure of records in Privacy...

  8. 21 CFR 21.71 - Disclosure of records in Privacy Act Record Systems; accounting required.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Disclosure of records in Privacy Act Record Systems; accounting required. 21.71 Section 21.71 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT... Record Systems to Persons Other Than the Subject Individual § 21.71 Disclosure of records in Privacy...

  9. 21 CFR 21.71 - Disclosure of records in Privacy Act Record Systems; accounting required.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Disclosure of records in Privacy Act Record Systems; accounting required. 21.71 Section 21.71 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT... Record Systems to Persons Other Than the Subject Individual § 21.71 Disclosure of records in Privacy...

  10. 78 FR 27001 - Horse Protection Act; Requiring Horse Industry Organizations To Assess and Enforce Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-09

    ... published in the Federal Register on June 7, 2012 (77 FR 33607-33619, Docket No. APHIS-2011-0030), and... Inspection Service 9 CFR Part 11 RIN 0579-AD43 Horse Protection Act; Requiring Horse Industry Organizations... Federal Register on June 7, 2012, and effective on July 9, 2012, we amended the horse...

  11. The Clean Air Act Amendments of 1990: Hazardous Air Pollutant Requirements and the DOE Clean Coal Technology Program

    SciTech Connect

    Moskowitz, P.D.; DePhillips, M.; Fthenakis, V.M.; Hemenway, A.

    1991-12-31

    The purpose of the US Department of Energy -- Office of Fossil Energy (DOE FE) Clean Coal Technology Program (CCTP) is to provide the US energy marketplace with advanced, efficient, and environmentally sound coal-based technologies. The design, construction, and operation of Clean Coal Technology Demonstration Projects (CCTDP) will generate data needed to make informed, confident decisions on the commercial readiness of these technologies. These data also will provide information needed to ensure a proactive response by DOE and its industrial partners to the establishment of new regulations or a reactive response to existing regulations promulgated by the US Environmental Protection Agency (EPA). The objectives of this paper are to: (1) Present a preliminary examination of the potential implications of the Clean Air Act Amendments (CAAA) -- Title 3 Hazardous Air Pollutant requirements to the commercialization of CCTDP; and (2) help define options available to DOE and its industrial partners to respond to this newly enacted Legislation.

  12. The Clean Air Act Amendments of 1990: Hazardous Air Pollutant Requirements and the DOE Clean Coal Technology Program

    SciTech Connect

    Moskowitz, P.D.; DePhillips, M.; Fthenakis, V.M. ); Hemenway, A. )

    1991-01-01

    The purpose of the US Department of Energy -- Office of Fossil Energy (DOE FE) Clean Coal Technology Program (CCTP) is to provide the US energy marketplace with advanced, efficient, and environmentally sound coal-based technologies. The design, construction, and operation of Clean Coal Technology Demonstration Projects (CCTDP) will generate data needed to make informed, confident decisions on the commercial readiness of these technologies. These data also will provide information needed to ensure a proactive response by DOE and its industrial partners to the establishment of new regulations or a reactive response to existing regulations promulgated by the US Environmental Protection Agency (EPA). The objectives of this paper are to: (1) Present a preliminary examination of the potential implications of the Clean Air Act Amendments (CAAA) -- Title 3 Hazardous Air Pollutant requirements to the commercialization of CCTDP; and (2) help define options available to DOE and its industrial partners to respond to this newly enacted Legislation.

  13. 75 FR 24862 - Removing Regulations Implementing the Fish and Wildlife Conservation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-06

    ...'' (59 FR 22951), E.O. 13175, and 512 DM 2. We have determined that there are no potential effects. This... Fish and Wildlife Service 50 CFR Part 83 RIN 1018-AX00 Removing Regulations Implementing the Fish and Wildlife Conservation Act AGENCY: Fish and Wildlife Service, Interior. ACTION: Proposed rule. SUMMARY:...

  14. 75 FR 36589 - Financial Crimes Enforcement Network; Amendment to the Bank Secrecy Act Regulations-Definitions...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-28

    ... revise the Bank Secrecy Act (``BSA'') regulations applicable to Money Services Businesses with regard to...-bank financial institutions that offer specific services (often in combination) and are without a... Services Business NPRM On May 12, 2009, FinCEN published an NPRM entitled ``Amendment to the Bank...

  15. Impact of Clean Air Act Regulations on Nitrogen Fate and Transport in Neuse River Basin

    EPA Science Inventory

    This study investigated impacts of Clean Air Act Amendment (CAAA) NOx emissions regulations on the fate and transport of nitrogen for two watersheds in the Neuse River Basin, North Carolina, USA from 1990 to 2020. The Soil and Water Assessment Tool (SWAT) and the Community Multi-...

  16. The National Labor Relations Act and the Regulation of Public Employee Collective Bargaining

    ERIC Educational Resources Information Center

    McCann, Walter; Smiley, Stafford

    1976-01-01

    The arguments for and against federal assumption of the responsibility for regulating the relationship between public employers and public employees are analyzed. It is suggested that the National Labor Relations Act should be extended to include them, thereby imposing upon them a duty to bargain collectively. Available from: the Harvard…

  17. 75 FR 40754 - Government in the Sunshine Act Regulations of the National Science Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-14

    ... From the Federal Register Online via the Government Publishing Office NATIONAL SCIENCE FOUNDATION 45 CFR Part 614 RIN 3145-AA53 Government in the Sunshine Act Regulations of the National Science Board AGENCY: National Science Board (NSB), National Science Foundation (NSF). ACTION: Direct final...

  18. 77 FR 234 - Rules and Regulations Under the Textile Fiber Products Identification Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-04

    ...; ] FEDERAL TRADE COMMISSION 16 CFR Part 303 Rules and Regulations Under the Textile Fiber Products Identification Act AGENCY: Federal Trade Commission (``FTC'' or ``Commission''). ACTION: Extension of the... to the following address: Federal Trade Commission, Office of the Secretary, Room H-113 (Annex...

  19. 77 FR 4498 - Rules and Regulations Under the Wool Products Labeling Act of 1939

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-30

    ...: Miscellaneous Rules: Final Rule, 63 FR 71582 (Dec. 29, 1998). \\7\\ Federal Trade Commission: Rules and... and Request for Public Comment on the Federal Trade Commission's Regulatory Review Program, 76 FR...; ] FEDERAL TRADE COMMISSION 16 CFR Part 300 Rules and Regulations Under the Wool Products Labeling Act...

  20. 76 FR 52295 - Amendment of Privacy Act Regulations, Request for Comments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR 43 CFR Part 2 RIN 1090-AA94 Amendment of Privacy Act Regulations, Request for Comments AGENCY: Office... on October 3, 2011. ADDRESSES: Send written comments, identified by RIN 1090-AA94, by one of...

  1. 76 FR 20569 - Horse Protection Act; Petition for Amendments to Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ... Animal and Plant Health Inspection Service 9 CFR Part 11 Horse Protection Act; Petition for Amendments to... changes to our horse protection regulations and our current enforcement practices and related policies... are noting, however, that certain requests in the petition lack authority in the Horse Protection...

  2. 22 CFR 91.1 - Answering inquiries regarding tariff acts and customs regulations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Answering inquiries regarding tariff acts and customs regulations. 91.1 Section 91.1 Foreign Relations DEPARTMENT OF STATE LEGAL AND RELATED SERVICES... matters upon which hey are not competent to pass....

  3. The actin gene ACT1 is required for phagocytosis, motility, and cell separation of Tetrahymena thermophila.

    PubMed

    Williams, Norman E; Tsao, Che-Chia; Bowen, Josephine; Hehman, Gery L; Williams, Ruth J; Frankel, Joseph

    2006-03-01

    A previously identified Tetrahymena thermophila actin gene (C. G. Cupples and R. E. Pearlman, Proc. Natl. Acad. Sci. USA 83:5160-5164, 1986), here called ACT1, was disrupted by insertion of a neo3 cassette. Cells in which all expressed copies of this gene were disrupted exhibited intermittent and extremely slow motility and severely curtailed phagocytic uptake. Transformation of these cells with inducible genetic constructs that contained a normal ACT1 gene restored motility. Use of an epitope-tagged construct permitted visualization of Act1p in the isolated axonemes of these rescued cells. In ACT1Delta mutant cells, ultrastructural abnormalities of outer doublet microtubules were present in some of the axonemes. Nonetheless, these cells were still able to assemble cilia after deciliation. The nearly paralyzed ACT1Delta cells completed cleavage furrowing normally, but the presumptive daughter cells often failed to separate from one another and later became reintegrated. Clonal analysis revealed that the cell cycle length of the ACT1Delta cells was approximately double that of wild-type controls. Clones could nonetheless be maintained for up to 15 successive fissions, suggesting that the ACT1 gene is not essential for cell viability or growth. Examination of the cell cortex with monoclonal antibodies revealed that whereas elongation of ciliary rows and formation of oral structures were normal, the ciliary rows of reintegrated daughter cells became laterally displaced and sometimes rejoined indiscriminately across the former division furrow. We conclude that Act1p is required in Tetrahymena thermophila primarily for normal ciliary motility and for phagocytosis and secondarily for the final separation of daughter cells.

  4. Review of orders and regulations requiring environmental protection

    SciTech Connect

    Kelly, E.; Cunningham, R.; Michael, D.

    1996-09-01

    With the increased awareness of and interest in potential ecological risks associated with past, current, and future Department of Energy (DOE) activities, DOE`s Defense Programs (DP) Office of Technical and Environmental Support sponsored a study to (1) evaluate the effectiveness of the current compliance-driven environmental protection and assessment efforts relative to ecological concerns; (2) explore the need for a more focused, integrated approach to address ecological impacts; and (3) identify the requirements for an integrated approach. The study explored four questions. (a) Which federal regulations and DOE orders either explicitly require ecological assessments or implicitly require them through environmental protection language? (b) What currently is being done at selected DOE facilities to implement these regulations and orders? (c) What are private sector industries doing in terms of ecological risk assessments and how do industry approaches and issues compare with those of DOE? (d) What, if anything, in addition to current efforts is needed to ensure the protection of ecological resources associated with DOE facilities, to support defensible decision making, and to improve efficiency? The results of this study are presented in a report titled {open_quotes}Integrated, Comprehensive Ecological Impact Assessments In Support of Department of Energy Decision Making{close_quotes}. This report is a companion document to that report. This report provides a more detailed discussion of the document reviews of the relevant environmental protection regulations and current and pending DOE orders. The main goal of the document reviews was to understand existing requirements for ecological data collection and impact assessments.

  5. 75 FR 6186 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Part 205...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-08

    ... Defense Acquisition Regulations System Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Part 205, Publicizing Contract Actions AGENCY: Defense Acquisition Regulations System... approved information collection requirement. SUMMARY: In compliance with Section 3506(c)(2)(A) of...

  6. 75 FR 20825 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; DoD Pilot...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... Defense Acquisition Regulations System Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; DoD Pilot Mentor-Protege Program AGENCY: Defense Acquisition Regulations System... approved information collection requirement. ] SUMMARY: In compliance with section 3506(c)(2)(A) of...

  7. 76 FR 50461 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Types of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-15

    ... Defense Acquisition Regulations System Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Types of Contracts AGENCY: Defense Acquisition Regulations System, Department of... information collection requirement. SUMMARY: In compliance with Section 3506(c)(2)(A) of the...

  8. 78 FR 70025 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-22

    ... Defense Acquisition Regulations System Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Subcontracting Policies and Procedures AGENCY: Defense Acquisition Regulations System... approved information collection requirement. SUMMARY: In compliance with section 3506(c)(2)(A) of...

  9. 78 FR 63461 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Foreign...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-24

    ... Defense Acquisition Regulations System Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Foreign Acquisition AGENCY: Defense Acquisition Regulations System, Department of...) 372-6094. Mail: Defense Acquisition Regulations System, Attn: Amy Williams, OUSD(AT&L)DPAP(DARS),...

  10. Industry invites regulation: the passage of the Pure Food and Drug Act of 1906.

    PubMed

    Barkan, I D

    1985-01-01

    Ending its 27-year stranglehold on proposals for federal pure food and drug legislation, Congress passed the Pure Food and Drug Act and its companion bill, the Meat Inspection Act, on June 30, 1906. An unprecedented convergence of consumer, scientific, and industrial support in 1906 prompted such action; most industries even planned for it, hoping regulation would restore the competitiveness of their products on weak foreign and domestic markets. The ways in which these interests converged, and the reasons therefore, suggest a change in their relationships to each other and with the federal government as America headed into the twentieth century. PMID:3881052

  11. Industry invites regulation: the passage of the Pure Food and Drug Act of 1906.

    PubMed Central

    Barkan, I D

    1985-01-01

    Ending its 27-year stranglehold on proposals for federal pure food and drug legislation, Congress passed the Pure Food and Drug Act and its companion bill, the Meat Inspection Act, on June 30, 1906. An unprecedented convergence of consumer, scientific, and industrial support in 1906 prompted such action; most industries even planned for it, hoping regulation would restore the competitiveness of their products on weak foreign and domestic markets. The ways in which these interests converged, and the reasons therefore, suggest a change in their relationships to each other and with the federal government as America headed into the twentieth century. Images p21-a p21-b PMID:3881052

  12. New paradigms for conserved, multifactorial, cis-acting regulation of meiotic recombination.

    PubMed

    Wahls, Wayne P; Davidson, Mari K

    2012-11-01

    How do cells position the Spo11 (Rec12)-dependent initiation of meiotic recombination at hotspots? The mechanisms are poorly understood and a prevailing view is that they differ substantially between phylogenetic groups. However, recent work discovered that individual species have multiple different DNA sequence-specific, protein-DNA complexes that regulate (and are essential for the activation of) recombination hotspots. The cis-acting elements function combinatorially with documented examples of synergism, antagonism and redundancy. Furthermore, we provide evidence that all currently well-defined modules of this multifactorial, cis-acting regulation are conserved functionally between taxa whose latest common ancestor occurred more than 1 billion years ago. Functionally conserved components include the ATF/CREB-family heterodimer Atf1-Pcr1 and its CRE-like DNA site M26, the CCAAT-box-binding complex Php2-Php3-Php5 and the CCAAT-box, and the zinc-finger protein Rst2 and its Oligo-C motif. The newfound multiplicity, functional redundancy and conservation of cis-acting controls constitute a paradigm shift with broad implications. They provide compelling evidence that most meiotic recombination is, like transcription, regulated by sequence-specific protein-DNA complexes. And the new findings provide important mechanistic insight, such as a solution to the conundrum that Prdm9 is a 'master regulator' of--yet is dispensable for--hotspot activity in mammals. PMID:22904082

  13. The Maharashtra Felling of Trees (Regulation) (Amendment) Act, 1988 (No. 26 of 1989), 5 August 1989.

    PubMed

    1989-01-01

    Among other things, this Act amends the Maharashtra (India) Felling of Trees (Regulation) Act, 1964, to authorize the Tree Officer to order the planting of trees in any land (other than government-designated drought land) that he thinks does not contain an adequate number of trees. Owners and occupiers of the land must comply with the order, after being given a reasonable opportunity to be heard. If they do not comply, they can be charged for expenses incurred in having the trees planted. In 1989 the government of West Bengal enacted The Indian Forest (West Bengal Amendment) Act, 1989 (No. 22 of 1988) (Calcutta Gazette, Extraordinary, Part III, 3 February 1989). This Act increases the punishment for various infractions of the Indian Forest Act, 1927, as applied to West Bengal and inserts new language relating to the power of officers to stop and search vehicles; the ability of the state government to seize contraband and related tools, vehicles, boats, and cattle; and punishment for abetting offenses delineated by the Act. PMID:12344326

  14. 20 CFR 667.250 - What requirements relate to the enforcement of the Military Selective Service Act?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... of the Military Selective Service Act? 667.250 Section 667.250 Employees' Benefits EMPLOYMENT AND... enforcement of the Military Selective Service Act? The requirements relating to the enforcement of the Military Selective Service Act are found at WIA section 189(h)....

  15. 20 CFR 667.250 - What requirements relate to the enforcement of the Military Selective Service Act?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... of the Military Selective Service Act? 667.250 Section 667.250 Employees' Benefits EMPLOYMENT AND... the enforcement of the Military Selective Service Act? The requirements relating to the enforcement of the Military Selective Service Act are found at WIA section 189(h)....

  16. 20 CFR 667.250 - What requirements relate to the enforcement of the Military Selective Service Act?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... of the Military Selective Service Act? 667.250 Section 667.250 Employees' Benefits EMPLOYMENT AND... the enforcement of the Military Selective Service Act? The requirements relating to the enforcement of the Military Selective Service Act are found at WIA section 189(h)....

  17. 20 CFR 667.250 - What requirements relate to the enforcement of the Military Selective Service Act?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... of the Military Selective Service Act? 667.250 Section 667.250 Employees' Benefits EMPLOYMENT AND... the enforcement of the Military Selective Service Act? The requirements relating to the enforcement of the Military Selective Service Act are found at WIA section 189(h)....

  18. 20 CFR 667.250 - What requirements relate to the enforcement of the Military Selective Service Act?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... of the Military Selective Service Act? 667.250 Section 667.250 Employees' Benefits EMPLOYMENT AND... enforcement of the Military Selective Service Act? The requirements relating to the enforcement of the Military Selective Service Act are found at WIA section 189(h)....

  19. 2 CFR 176.50 - Award term-Reporting and registration requirements under section 1512 of the Recovery Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... responsible for ensuring that their recipients report information required under the Recovery Act in a timely... report on use of Recovery Act funds provided through this award. Information from these reports will be... awards funded with Recovery Act funds. A Dun and Bradstreet Data Universal Numbering System (DUNS)...

  20. 2 CFR 176.50 - Award term-Reporting and registration requirements under section 1512 of the Recovery Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... responsible for ensuring that their recipients report information required under the Recovery Act in a timely... report on use of Recovery Act funds provided through this award. Information from these reports will be... awards funded with Recovery Act funds. A Dun and Bradstreet Data Universal Numbering System (DUNS)...

  1. GABAA receptor regulation of voluntary ethanol drinking requires PKCepsilon.

    PubMed

    Besheer, Joyce; Lepoutre, Veronique; Mole, Beth; Hodge, Clyde W

    2006-11-01

    Protein kinase C (PKC) regulates a variety of neural functions, including ion channel activity, neurotransmitter release, receptor desensitization and differentiation. We have shown previously that mice lacking the epsilon-isoform of PKC (PKCepsilon) self-administer 75% less ethanol and exhibit supersensitivity to acute ethanol and allosteric positive modulators of GABA(A) receptors when compared with wild-type controls. The purpose of the present study was to examine involvement of PKCepsilon in GABA(A) receptor regulation of voluntary ethanol drinking. To address this question, PKCepsilon null-mutant and wild-type control mice were allowed to drink ethanol (10% v/v) vs. water on a two-bottle continuous access protocol. The effects of diazepam (nonselective GABA(A) BZ positive modulator), zolpidem (GABA(A) alpha1 agonist), L-655,708 (BZ-sensitive GABA(A) alpha5 inverse agonist), and flumazenil (BZ antagonist) were then tested on ethanol drinking. Ethanol intake (grams/kg/day) by wild-type mice decreased significantly after diazepam or zolpidem but increased after L-655,708 administration. Flumazenil antagonized diazepam-induced reductions in ethanol drinking in wild-type mice. However, ethanol intake by PKCepsilon null mice was not altered by any of the GABAergic compounds even though effects were seen on water drinking in these mice. Increased acute sensitivity to ethanol and diazepam, which was previously reported, was confirmed in PKCepsilon null mice. Thus, results of the present study show that PKCepsilon null mice do not respond to doses of GABA(A) BZ receptor ligands that regulate ethanol drinking by wild-type control mice. This suggests that PKCepsilon may be required for GABA(A) receptor regulation of chronic ethanol drinking.

  2. 26 CFR 1.706-2T - Temporary regulations; question and answer under the Tax Reform Act of 1984.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Temporary regulations; question and answer under the Tax Reform Act of 1984. 1.706-2T Section 1.706-2T Internal Revenue INTERNAL REVENUE SERVICE...-2T Temporary regulations; question and answer under the Tax Reform Act of 1984. Question 1:...

  3. 26 CFR 18.0 - Effective date of temporary regulations under the Subchapter S Revision Act of 1982.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 14 2014-04-01 2013-04-01 true Effective date of temporary regulations under the Subchapter S Revision Act of 1982. 18.0 Section 18.0 Internal Revenue INTERNAL REVENUE SERVICE... SUBCHAPTER S REVISION ACT OF 1982 § 18.0 Effective date of temporary regulations under the Subchapter...

  4. 26 CFR 18.0 - Effective date of temporary regulations under the Subchapter S Revision Act of 1982.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 14 2012-04-01 2012-04-01 false Effective date of temporary regulations under the Subchapter S Revision Act of 1982. 18.0 Section 18.0 Internal Revenue INTERNAL REVENUE SERVICE... SUBCHAPTER S REVISION ACT OF 1982 § 18.0 Effective date of temporary regulations under the Subchapter...

  5. 78 FR 45842 - Amendments to the 2013 Mortgage Rules Under the Real Estate Settlement Procedure Act (Regulation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-30

    ... From the Federal Register Online via the Government Publishing Office BUREAU OF CONSUMER FINANCIAL PROTECTION 12 CFR Parts 1024 and 1026 RIN 3170-AA37 Amendments to the 2013 Mortgage Rules Under the Real Estate Settlement Procedure Act (Regulation X) and the Truth in Lending Act (Regulation Z) Correction...

  6. 76 FR 63817 - Disclosure of Information; Privacy Act Regulations; Notice and Amendments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-14

    ... supervisory agency, for purposes of Sec. 309.6, to which exempt records could be disclosed.\\1\\ \\1\\ 76 FR 35963.... D. Plain Language Section 722 of the Gramm-Leach-Bliley Act (Pub. L. 106-102, 113 Stat. 1338, 1471), requires the Federal banking agencies to use plain language in all proposed and final rules published...

  7. 77 FR 29982 - Federal Acquisition Regulation; Submission for OMB Review; Davis Bacon Act-Price Adjustment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ...: A. Purpose Government contracting officers may include FAR clause 52.222-32, Davis-Bacon Act--Price... may reasonably require. The information is used by ] Government contracting officers to establish the... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF...

  8. 78 FR 60898 - Regulation on Definition and Requirements for a Nationally Recognized Testing Laboratory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ..., ``definition and requirements for a nationally recognized testing laboratory'' (The Regulation). The Regulation... 1910.7, ``definition and requirements for a nationally recognized testing laboratory'' (the Regulation... specified by the Regulation on the Definition and Requirements of a Nationally Recognized Testing...

  9. An Arabidopsis F-box protein acts as a transcriptional co-factor to regulate floral development.

    PubMed

    Chae, Eunyoung; Tan, Queenie K-G; Hill, Theresa A; Irish, Vivian F

    2008-04-01

    Plants flower in response to both environmental and endogenous signals. The Arabidopsis LEAFY (LFY) transcription factor is crucial in integrating these signals, and acts in part by activating the expression of multiple floral homeotic genes. LFY-dependent activation of the homeotic APETALA3 (AP3) gene requires the activity of UNUSUAL FLORAL ORGANS (UFO), an F-box component of an SCF ubiquitin ligase, yet how this regulation is effected has remained unclear. Here, we show that UFO physically interacts with LFY both in vitro and in vivo, and this interaction is necessary to recruit UFO to the AP3 promoter. Furthermore, a transcriptional repressor domain fused to UFO reduces endogenous LFY activity in plants, supporting the idea that UFO acts as part of a transcriptional complex at the AP3 promoter. Moreover, chemical or genetic disruption of proteasome activity compromises LFY-dependent AP3 activation, indicating that protein degradation is required to promote LFY activity. These results define an unexpected role for an F-box protein in functioning as a DNA-associated transcriptional co-factor in regulating floral homeotic gene expression. These results suggest a novel mechanism for promoting flower development via protein degradation and concomitant activation of the LFY transcription factor. This mechanism may be widely conserved, as homologs of UFO and LFY have been identified in a wide array of plant species. PMID:18287201

  10. An Arabidopsis F-box protein acts as a transcriptional co-factor to regulate floral development.

    PubMed

    Chae, Eunyoung; Tan, Queenie K-G; Hill, Theresa A; Irish, Vivian F

    2008-04-01

    Plants flower in response to both environmental and endogenous signals. The Arabidopsis LEAFY (LFY) transcription factor is crucial in integrating these signals, and acts in part by activating the expression of multiple floral homeotic genes. LFY-dependent activation of the homeotic APETALA3 (AP3) gene requires the activity of UNUSUAL FLORAL ORGANS (UFO), an F-box component of an SCF ubiquitin ligase, yet how this regulation is effected has remained unclear. Here, we show that UFO physically interacts with LFY both in vitro and in vivo, and this interaction is necessary to recruit UFO to the AP3 promoter. Furthermore, a transcriptional repressor domain fused to UFO reduces endogenous LFY activity in plants, supporting the idea that UFO acts as part of a transcriptional complex at the AP3 promoter. Moreover, chemical or genetic disruption of proteasome activity compromises LFY-dependent AP3 activation, indicating that protein degradation is required to promote LFY activity. These results define an unexpected role for an F-box protein in functioning as a DNA-associated transcriptional co-factor in regulating floral homeotic gene expression. These results suggest a novel mechanism for promoting flower development via protein degradation and concomitant activation of the LFY transcription factor. This mechanism may be widely conserved, as homologs of UFO and LFY have been identified in a wide array of plant species.

  11. New paradigms for conserved, multifactorial, cis-acting regulation of meiotic recombination

    PubMed Central

    Wahls, Wayne P.; Davidson, Mari K.

    2012-01-01

    How do cells position the Spo11 (Rec12)-dependent initiation of meiotic recombination at hotspots? The mechanisms are poorly understood and a prevailing view is that they differ substantially between phylogenetic groups. However, recent work discovered that individual species have multiple different DNA sequence-specific, protein–DNA complexes that regulate (and are essential for the activation of) recombination hotspots. The cis-acting elements function combinatorially with documented examples of synergism, antagonism and redundancy. Furthermore, we provide evidence that all currently well-defined modules of this multifactorial, cis-acting regulation are conserved functionally between taxa whose latest common ancestor occurred more than 1 billion years ago. Functionally conserved components include the ATF/CREB-family heterodimer Atf1-Pcr1 and its CRE-like DNA site M26, the CCAAT-box-binding complex Php2-Php3-Php5 and the CCAAT-box, and the zinc-finger protein Rst2 and its Oligo-C motif. The newfound multiplicity, functional redundancy and conservation of cis-acting controls constitute a paradigm shift with broad implications. They provide compelling evidence that most meiotic recombination is, like transcription, regulated by sequence-specific protein–DNA complexes. And the new findings provide important mechanistic insight, such as a solution to the conundrum that Prdm9 is a ‘master regulator’ of—yet is dispensable for—hotspot activity in mammals. PMID:22904082

  12. 21 CFR 1271.10 - Are my HCT/P's regulated solely under section 361 of the PHS Act and the regulations in this part...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Are my HCT/P's regulated solely under section 361 of the PHS Act and the regulations in this part, and if so what must I do? 1271.10 Section 1271.10 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) REGULATIONS UNDER CERTAIN OTHER ACTS ADMINISTERED...

  13. 16 CFR 803.30 - Formal and informal interpretations of requirements under the Act and the rules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS... of the act are or may be applicable and (3) the question(s) that the applicant wishes resolved....

  14. 16 CFR 803.30 - Formal and informal interpretations of requirements under the Act and the rules.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS... of the act are or may be applicable and (3) the question(s) that the applicant wishes resolved....

  15. Modeling Requirements for Simulating the Effects of Extreme Acts of Terrorism: A White Paper

    SciTech Connect

    Allen, M.; Hiebert-Dodd, K.; Marozas, D.; Paananen, O.; Pryor, R.J.; Reinert, R.K.

    1998-10-01

    This white paper presents the initial requirements for developing a new computer model for simulating the effects of extreme acts of terrorism in the United States. General characteristics of the model are proposed and the level of effort to prepare a complete written description of the model, prior to coding, is detailed. The model would simulate the decision processes and interactions of complex U. S. systems engaged in responding to and recovering from four types of terrorist incidents. The incident scenarios span the space of extreme acts of terrorism that have the potential to affect not only the impacted area, but also the entire nation. The model would be useful to decision-makers in assessing and analyzing the vulnerability of the nation's complex infrastructures, in prioritizing resources to reduce risk, and in planning strategies for immediate response and for subsequent recovery from terrorist incidents.

  16. DEVELOPMENT OF WATER SUPPLY TECHNOLOGY TO MEET THE REQUIREMENTS OF THE SAFE DRINKING WATER ACT OF 1996: TRENDS AND PROSPECTS.

    EPA Science Inventory

    The passage of the U.S. Safe Drinking Water Act (SDWA) in 1974 has had a major impact on the way water is treated and delivered in the U.S. The Act established national drinking water regulations for more than 170,000 public drinking water systems serving over 250 million people ...

  17. 76 FR 26787 - Short Sale Reporting Study Required by Dodd-Frank Act Section 417(a)(2)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-09

    ...(b)(8). \\4\\ See 17 CFR 242.200(a). \\5\\ See Exchange Act Release No. 50103 (July 28, 2004), 69 FR...., Exchange Act Release No. 58775 (Oct. 14, 2008), 73 FR 61690 (Oct. 17, 2008). \\13\\ In adopting Regulation.... 50103, 69 FR 48008, 48015 (Aug. 6, 2004) (citations omitted). Q3. The Commission requests comment on...

  18. USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase

    PubMed Central

    Fan, Yihui; Mao, Renfang; Yu, Yang; Liu, Shangfeng; Shi, Zhongcheng; Cheng, Jin; Zhang, Huiyuan; An, Lei; Zhao, Yanling; Xu, Xin; Chen, Zhenghu; Kogiso, Mari; Zhang, Dekai; Zhang, Hong; Zhang, Pumin; Jung, Jae U.; Li, Xiaonan

    2014-01-01

    Lys63-linked polyubiquitination of RIG-I is essential in antiviral immune defense, yet the molecular mechanism that negatively regulates this critical step is poorly understood. Here, we report that USP21 acts as a novel negative regulator in antiviral responses through its ability to bind to and deubiquitinate RIG-I. Overexpression of USP21 inhibited RNA virus–induced RIG-I polyubiquitination and RIG-I–mediated interferon (IFN) signaling, whereas deletion of USP21 resulted in elevated RIG-I polyubiquitination, IRF3 phosphorylation, IFN-α/β production, and antiviral responses in MEFs in response to RNA virus infection. USP21 also restricted antiviral responses in peritoneal macrophages (PMs) and bone marrow–derived dendritic cells (BMDCs). USP21-deficient mice spontaneously developed splenomegaly and were more resistant to VSV infection with elevated production of IFNs. Chimeric mice with USP21-deficient hematopoietic cells developed virus-induced splenomegaly and were more resistant to VSV infection. Functional comparison of three deubiquitinases (USP21, A20, and CYLD) demonstrated that USP21 acts as a bona fide RIG-I deubiquitinase to down-regulate antiviral response independent of the A20 ubiquitin-editing complex. Our studies identify a previously unrecognized role for USP21 in the negative regulation of antiviral response through deubiquitinating RIG-I. PMID:24493797

  19. Risk adjustment under the Affordable Care Act: a guide for federal and state regulators.

    PubMed

    Hall, Mark A

    2011-05-01

    To achieve the aims of the Affordable Care Act, state and federal regulators must construct an effective system of risk adjustment, one that protects health insurers that attract a disproportionate share of patients with poor health risks. This brief, which summarizes a Commonwealth Fund–supported conference of leading risk adjustment experts, explores the challenges regulators will face, considers the consequences of the law's risk adjustment provisions, and analyzes the merits of different risk adjustment strategies. Among other recommendations, the brief suggests that regulators use diagnostic rather than only demographic risk measures, that they allow states some but limited flexibility to tailor risk adjustment methods to local circumstances, and that they phase in the use of risk transfer payments to give insurers more time to predict and understand the full effects of risk adjustment.

  20. Regulation of toxic pollutants under the Clean Water Act: EPA's ten-year rulemaking nears completion

    SciTech Connect

    Wyche, B.W.

    1983-01-01

    Whether it's footdragging, or compliance is impossible, the Environmental Protection Agency (EPA) usually fails to meet its deadlines for issuing regulations. The best-known case is probably EPA's 10-year struggle to establish regulatory controls on toxic pollutants under the Clean Water Act. The developmental process is reviewed from the initial statutory framework (enacted in 1948) and the effluent limitations amendments (legislated in 1972), through its litigation history, to an analysis of the federal district court's three substantive opinions delivered during 1982. The author considers the possibility of legislative intervention because deadlines for compliance have been issued but the regulations have not. He concludes that without Toxics Consent Decree litigation, the toxic pollutant control program might have become a reality. EPA's toxic pollutant control regulations as of April 1, 1983, are tabulated. 129 references, 4 tables.

  1. Employee Retirement Income Security Act of 1974; rules and regulations for administration and enforcement; claims procedure. Final regulation; delay of applicability date.

    PubMed

    2001-07-01

    This action delays for at least six months and not more than one year the applicability date for the regulation governing minimum requirements for benefit claims procedures of group health plans covered by Title I of the Employee Retirement Income Security Act. As published on November 21, 2000, the benefit claims procedure would be applicable to claims filed on or after January 1, 2002. The current action amends the regulation so that it will apply to group health claims filed on or after the first day of the first plan year beginning on or after July 1, 2002, but in no event later than January 1, 2003. This action provides a limited additional period within which group health plan sponsors, administrators, and service providers can bring their claims processing systems into compliance with the new requirements. A postponement of the applicability date with respect to group health claims will allow a more orderly transition to the new standards and will avoid the confusion and additional expense that would be caused if certain pending Congressional bills are enacted before or soon after the original applicability date. This action does not apply to pension plans or plans providing disability or welfare benefits (other than group health). For these plans, the regulation will continue to be applicable to claims filed on or after January 1, 2002.

  2. 16 CFR 301.2 - General requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... REGULATIONS UNDER FUR PRODUCTS LABELING ACT Regulations § 301.2 General requirements. (a) Each and every fur... with the requirements of the act and rules and regulations. (b) Each and every fur shall be invoiced in conformity with the requirements of the act and rules and regulations. (c) Any advertising of fur products...

  3. 16 CFR 301.2 - General requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... REGULATIONS UNDER FUR PRODUCTS LABELING ACT Regulations § 301.2 General requirements. (a) Each and every fur... with the requirements of the act and rules and regulations. (b) Each and every fur shall be invoiced in conformity with the requirements of the act and rules and regulations. (c) Any advertising of fur products...

  4. 16 CFR 301.2 - General requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... REGULATIONS UNDER FUR PRODUCTS LABELING ACT Regulations § 301.2 General requirements. (a) Each and every fur... with the requirements of the act and rules and regulations. (b) Each and every fur shall be invoiced in conformity with the requirements of the act and rules and regulations. (c) Any advertising of fur products...

  5. 16 CFR 301.2 - General requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... REGULATIONS UNDER FUR PRODUCTS LABELING ACT Regulations § 301.2 General requirements. (a) Each and every fur... with the requirements of the act and rules and regulations. (b) Each and every fur shall be invoiced in conformity with the requirements of the act and rules and regulations. (c) Any advertising of fur products...

  6. 16 CFR 301.2 - General requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... REGULATIONS UNDER FUR PRODUCTS LABELING ACT Regulations § 301.2 General requirements. (a) Each and every fur... with the requirements of the act and rules and regulations. (b) Each and every fur shall be invoiced in conformity with the requirements of the act and rules and regulations. (c) Any advertising of fur products...

  7. Cis elements and trans-acting factors affecting regulation of a nonphotosynthetic light-regulated gene for chloroplast glutamine synthetase.

    PubMed Central

    Tjaden, G; Edwards, J W; Coruzzi, G M

    1995-01-01

    The glutamine synthetase (GS) gene family in pea (Pisum sativum) consists of four nuclear genes encoding distinct isoenzymes. Molecular studies have show that the GS2 gene encoding chloroplast-localized GS is expected in specific cell types and is regulated by diverse factors such as light and photorespiration. Here, we present the nucleotide sequence of the pea GS2 gene promoter. To identify the elements involved in regulation of GS2 expression, GS2 promoter-deletion analyses were performed using GS2-GUS fusions in tobacco (Nicotiana tabacum). This analysis revealed that the GS2 transit peptide is not required for mesophyll cell-specific expression of beta-glucuronidase (GUS). GUS activity was induced 2- to 4-fold in light-grown versus etiolated T1 seedlings. However, high levels of GUS activity were observed in etiolated seedlings. This observation demonstrated that regulation of expression of GS2, a nonphotosynthetic light-regulated gene, involves additional factors. A 323-bp GS2 promoter sequence is sufficient to confer light regulation to the GUS reporter gene in leaves of mature transgenic tobacco. Light-regulated expression of this pea gene promoter is observed in both tobacco and Arabidopsis, suggesting that the regulatory elements are conserved. Gel-shift analysis detected DNA-protein complexes formed with potential transcription elements within this short, light-responsive GS2 promoter fragment. PMID:7630938

  8. 78 FR 13298 - Notice of Retrospective Review of the Americans With Disabilities Act Regulations for Over-the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-27

    ... Statement in the Federal Register published on April 11, 2000 (65 FR 19477). FOR FURTHER INFORMATION CONTACT... Act Regulations for Over-the-Road Bus Operators; Request for Comments AGENCY: Office of the Secretary...) implementing regulations for over-the-road bus (OTRB) operators. The DOT will review regulations specified...

  9. 75 FR 9114 - Defense Federal Acquisition Regulation Supplement; Additional Requirements Applicable to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-01

    ... Defense Acquisition Regulations System 48 CFR Part 217 Defense Federal Acquisition Regulation Supplement; Additional Requirements Applicable to Multiyear Contracts (DFARS Case 2008-D023) AGENCY: Defense Acquisition... is issuing this interim rule amending the Defense Federal Acquisition Regulation Supplement...

  10. 76 FR 72916 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... comments, identified by OMB Control Number 0704-0454, using any of the following methods: Email: dfars@osd... Defense Acquisition Regulations System Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Administrative Matters AGENCY: Defense Acquisition Regulations System, Department...

  11. 78 FR 70294 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-25

    ... Defense Acquisition Regulations System Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Administrative Matters AGENCY: Defense Acquisition Regulations System, Department of... technology. The Office of Management and Budget (OMB) has approved this information collection under...

  12. 77 FR 43076 - Federal Acquisition Regulation; Information Collection; Value Engineering Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    ... Regulation; Information Collection; Value Engineering Requirements AGENCIES: Department of Defense (DOD... approved information collection requirement concerning Value Engineering Requirements. Public comments are...: Submit comments identified by Information Collection 9000- 0027, Value Engineering Requirements, by...

  13. 75 FR 45104 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Contract...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-02

    ... Defense Acquisition Regulations System Information Collection Requirement; Defense Federal Acquisition... Regulations System, Department of Defense (DoD). ACTION: Notice and request for comments. SUMMARY: In... announces the proposed extension of a public information collection requirement and seeks public comment...

  14. 75 FR 68331 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; DFARS Part...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-05

    ... Defense Acquisition Regulations System Information Collection Requirement; Defense Federal Acquisition... Acquisition Regulations System, Department of Defense (DoD). ACTION: Notice and request for comments regarding a proposed extension of an approved information collection requirement. SUMMARY: In compliance...

  15. 75 FR 26739 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Part 244...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... Defense Acquisition Regulations System Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Part 244, Subcontracting Policies and Procedures (OMB Control Number 0704-0253) AGENCY... regarding a proposed extension of an approved information collection requirement. SUMMARY: In...

  16. Evidence implicating the 5' untranslated region of Listeria monocytogenes actA in the regulation of bacterial actin-based motility.

    PubMed

    Wong, Kendy K Y; Bouwer, H G Archie; Freitag, Nancy E

    2004-02-01

    The ActA protein of Listeria monocytogenes is a major virulence factor, essential for the recruitment and polymerization of host actin filaments that lead to intracellular motility and cell-to-cell spread of bacteria within the infected host. The expression of actA is tightly regulated and is strongly induced only when L. monocytogenes is within the host cytosol. Intracellular induction of actA expression is mediated through a single promoter element that directs the expression of a messenger RNA with a long (150 bp) 5' untranslated region (UTR). Deletion of the actA+3 to +130 upstream region was found to result in bacterial mutants that were no longer capable of intracellular actin recruitment or cell-to-cell spread, thus indicating that this region is important for actA expression. L. monocytogenes strains that contained smaller deletions (21-23 bp) within the actA upstream region demonstrated a range of actA expression levels that coincided with the amount of bacterial cell-to-cell spread observed within infected monolayers. A correlation appeared to exist between levels of actA expression and the ability of L. monocytogenes to transition from uniform actin accumulation surrounding individual bacteria (actin clouds) to directional assembly and the formation of actin tails. Bacterial mutants containing deletions that most significantly altered the predicted secondary structure of the actA mRNA 5' UTR had the largest reductions in actA expression. These results suggest that the actA 5' UTR is required for maximal ActA synthesis and that a threshold level of ActA synthesis must be achieved to promote the transition from bacteria-associated actin clouds to directional actin assembly and movement.

  17. 75 FR 10790 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-09

    ... Regulation Supplement; Notification Requirements for Critical Safety Items AGENCY: Defense Acquisition... Supplement (DFARS) Notification Requirements for Critical Safety Items; OMB Control Number 0704-0441....

  18. GIGANTEA acts in blue light signaling and has biochemically separable roles in circadian clock and flowering time regulation.

    PubMed

    Martin-Tryon, Ellen L; Kreps, Joel A; Harmer, Stacey L

    2007-01-01

    Circadian clocks are widespread in nature. In higher plants, they confer a selective advantage, providing information regarding not only time of day but also time of year. Forward genetic screens in Arabidopsis (Arabidopsis thaliana) have led to the identification of many clock components, but the functions of most of these genes remain obscure. To identify both new constituents of the circadian clock and new alleles of known clock-associated genes, we performed a mutant screen. Using a clock-regulated luciferase reporter, we isolated new alleles of ZEITLUPE, LATE ELONGATED HYPOCOTYL, and GIGANTEA (GI). GI has previously been reported to function in red light signaling, central clock function, and flowering time regulation. Characterization of this and other GI alleles has helped us to further define GI function in the circadian system. We found that GI acts in photomorphogenic and circadian blue light signaling pathways and is differentially required for clock function in constant red versus blue light. Gene expression and epistasis analyses show that TIMING OF CHLOROPHYLL A/B BINDING PROTEIN1 (TOC1) expression is not solely dependent upon GI and that GI expression is only indirectly affected by TOC1, suggesting that GI acts both in series with and in parallel to TOC1 within the central circadian oscillator. Finally, we found that the GI-dependent promotion of CONSTANS expression and flowering is intact in a gi mutant with altered circadian regulation. Thus GI function in the regulation of a clock output can be biochemically separated from its role within the circadian clock.

  19. ATH1 and KNAT2 proteins act together in regulation of plant inflorescence architecture.

    PubMed

    Li, Yang; Pi, Limin; Huang, Hai; Xu, Lin

    2012-02-01

    The inflorescence of flowering plants is a highly organized structure, not only contributing to plant reproductive processes, but also constituting an important part of the entire plant morphology. Previous studies have revealed that the class-I KNOTTED1-like homeobox (KNOX) genes BREVIPEDICELLUS (BP or KNAT1), KNAT2, and KNAT6 play essential roles in inflorescence architecture. Pedicel morphology is known to contribute greatly to inflorescence architecture, and BP negatively regulates KNAT2 and KNAT6 to ensure that pedicels have a normal upward-pointing orientation. These findings indicate that a genetic network exists in controlling pedicel orientation, but how this network functions in the developmental process remains elusive. Here it is reported that the ARABIDOPSIS THALIANA HOMEOBOX GENE1 (ATH1) gene, which belongs to the BELL1-like homeodomain gene family, is a new member participating in regulating pedicel orientation in the class-I KNOX network. In a genetic screening for suppressors of isoginchaku-2D, a gain-of-function ASYMMETRIC LEAVES2 mutant that displays downward-pointing pedicels, a suppressor mutant was obtained. Characterization of this mutant revealed that the mutation corresponds to ATH1. Genetic analysis indicated that ATH1 acts mainly in the KNAT2 pathway. Yeast two-hybrid and bimolecular fluorescence complementation assays demonstrated that ATH1 physically interacts with KNAT2. The data indicate that the ATH1-KNAT2 complex acts redundantly with KNAT6, both of which are negatively regulated by BP during pedicel development.

  20. Nuclear power meets the 101st Congress, a {open_quotes}one-act{close_quotes} comedy: Regulation of Nuclear Regulatory Commission licensees under the Clean Air Act

    SciTech Connect

    Goldsmith, R.

    1992-12-31

    In the Clean Air Act Amendments of 1977, Congress directed the Environmental Protection Agency (EPA) to regulate all radioactive pollutants, including those emitted from facilities licensed and regulated under the Atomic Energy Act (AEA) by the Nuclear Regulatory Commission (NRC). Thus began the era of so-called {open_quotes}dual regulation.{close_quotes} Thirteen years later, that era ended with the passage of section 112(d)(9) of the Clean Air Act Amendments of 1990, which authorized the EPA to refrain from regulating any category of NRC-licensed facility if it found that NRC regulation was adequate to protect public health. This story of how Congress reversed regulatory policy is actually a story more about nuclear power than air pollution. Dual regulation was authorized in 1977 because of two concerns: fears about the public health risks associated with the nation`s growing commitment to nuclear power and doubts about the integrity of nuclear regulation by the NRC. Although neither of these concerns had abated by 1990, the legislative process was so adroitly manipulated by the proponents of nuclear power that Congress, unwittingly, restored the NRC`s regulatory monopoly.

  1. The Arabidopsis LYST INTERACTING PROTEIN 5 Acts in Regulating Abscisic Acid Signaling and Drought Response.

    PubMed

    Xia, Zongliang; Huo, Yongjin; Wei, Yangyang; Chen, Qiansi; Xu, Ziwei; Zhang, Wei

    2016-01-01

    Multivesicular bodies (MVBs) are unique endosomes containing vesicles in the lumens and play essential roles in many eukaryotic cellular processes. The Arabidopsis LYST INTERACTING PROTEIN 5 (LIP5), a positive regulator of MVB biogenesis, has critical roles in biotic and abiotic stress responses. However, whether the abscisic acid (ABA) signaling is involved in LIP5-mediated stress response is largely unknown. Here, we report that LIP5 functions in regulating ABA signaling and drought response in Arabidopsis. Analyses of a LIP5 promoter-β-glucuronidase (GUS) construct revealed substantial GUS activity in whole seedlings. The expression of LIP5 was induced by ABA and drought, and overexpression of LIP5 led to ABA hypersensitivity, enhanced stomatal closure, reduced water loss, and, therefore, increased drought tolerance. On the contrary, LIP5 knockdown mutants showed ABA-insensitive phenotypes and reduced drought tolerance; suggesting that LIP5 acts in regulating ABA response. Further analysis using a fluorescent dye revealed that ABA and water stress induced cell endocytosis or vesicle trafficking in a largely LIP5-dependent manner. Furthermore, expression of several drought- or ABA-inducible marker genes was significantly down-regulated in the lip5 mutant seedlings. Collectively, our data suggest that LIP5 positively regulates drought tolerance through ABA-mediated cell signaling. PMID:27313589

  2. The Arabidopsis LYST INTERACTING PROTEIN 5 Acts in Regulating Abscisic Acid Signaling and Drought Response

    PubMed Central

    Xia, Zongliang; Huo, Yongjin; Wei, Yangyang; Chen, Qiansi; Xu, Ziwei; Zhang, Wei

    2016-01-01

    Multivesicular bodies (MVBs) are unique endosomes containing vesicles in the lumens and play essential roles in many eukaryotic cellular processes. The Arabidopsis LYST INTERACTING PROTEIN 5 (LIP5), a positive regulator of MVB biogenesis, has critical roles in biotic and abiotic stress responses. However, whether the abscisic acid (ABA) signaling is involved in LIP5-mediated stress response is largely unknown. Here, we report that LIP5 functions in regulating ABA signaling and drought response in Arabidopsis. Analyses of a LIP5 promoter-β-glucuronidase (GUS) construct revealed substantial GUS activity in whole seedlings. The expression of LIP5 was induced by ABA and drought, and overexpression of LIP5 led to ABA hypersensitivity, enhanced stomatal closure, reduced water loss, and, therefore, increased drought tolerance. On the contrary, LIP5 knockdown mutants showed ABA-insensitive phenotypes and reduced drought tolerance; suggesting that LIP5 acts in regulating ABA response. Further analysis using a fluorescent dye revealed that ABA and water stress induced cell endocytosis or vesicle trafficking in a largely LIP5-dependent manner. Furthermore, expression of several drought- or ABA-inducible marker genes was significantly down-regulated in the lip5 mutant seedlings. Collectively, our data suggest that LIP5 positively regulates drought tolerance through ABA-mediated cell signaling. PMID:27313589

  3. Identification of trans-acting factors regulating SamDC expression in Oryza sativa

    SciTech Connect

    Basu, Supratim; Roychoudhury, Aryadeep; Sengupta, Dibyendu N.

    2014-03-07

    Highlights: • Identification of cis elements responsible for SamDC expression by in silico analysis. • qPCR analysis of SamDC expression to abiotic and biotic stress treatments. • Detection of SamDC regulators using identified cis-elements as probe by EMSA. • Southwestern Blot analysis to predict the size of the trans-acting factors. - Abstract: Abiotic stress affects the growth and productivity of crop plants; to cope with the adverse environmental conditions, plants have developed efficient defense machinery comprising of antioxidants like phenolics and flavonoids, and osmolytes like polyamines. SamDC is a key enzyme in the polyamine biosynthesis pathway in plants. In our present communication we have done in silico analysis of the promoter region of SamDC to look for the presence of different cis-regulatory elements contributing to its expression. Based on the presence of different cis-regulatory elements we completed comparative analysis of SamDC gene expression in rice lamina of IR-29 and Nonabokra by qPCR in response to the abiotic stress treatments of salinity, drought, cold and the biotic stress treatments of ABA and light. Additionally, to explore the role of the cis-regulatory elements in regulating the expression of SamDC gene in plants we comparatively analyzed the binding of rice nuclear proteins prepared from IR-29 and Nonabokra undergoing various stress treatments. The intensity of the complex formed was low and inducible in IR-29 in contrast to Nonabokra. Southwestern blot analysis helped in predicting the size of the trans-acting factors binding to these cis-elements. To our knowledge this is the first report on the comprehensive analysis of SamDC gene expression in rice and identification of the trans-acting factors regulating its expression.

  4. Safety regulation and firm size: effects of the Coal Mine Health and Safety Act of 1969

    SciTech Connect

    Neumann, G.R.; Nelson, J.P.

    1982-10-01

    The Coal Mine Health and Safety Act of 1969 has contributed to the decline in mine productivity, which must be weighed against safer working conditions for the miners. There may be some overstatement of the benefits if only fatalities are considered, however, because there was an increase in non-fatal accidents after 1970. Safety regulations have forced the closure of some small mines and raised some questions about the tradeoffs necessary when work safety reduces competition. A review of pertinent legislation, a hedonic wage-differential model, and the effects of union wage policy are applied to these questions. 4 tables. (DCK)

  5. translin Is Required for Metabolic Regulation of Sleep.

    PubMed

    Murakami, Kazuma; Yurgel, Maria E; Stahl, Bethany A; Masek, Pavel; Mehta, Aradhana; Heidker, Rebecca; Bollinger, Wesley; Gingras, Robert M; Kim, Young-Joon; Ja, William W; Suter, Beat; DiAngelo, Justin R; Keene, Alex C

    2016-04-01

    Dysregulation of sleep or feeding has enormous health consequences. In humans, acute sleep loss is associated with increased appetite and insulin insensitivity, while chronically sleep-deprived individuals are more likely to develop obesity, metabolic syndrome, type II diabetes, and cardiovascular disease. Conversely, metabolic state potently modulates sleep and circadian behavior; yet, the molecular basis for sleep-metabolism interactions remains poorly understood. Here, we describe the identification of translin (trsn), a highly conserved RNA/DNA binding protein, as essential for starvation-induced sleep suppression. Strikingly, trsn does not appear to regulate energy stores, free glucose levels, or feeding behavior suggesting the sleep phenotype of trsn mutant flies is not a consequence of general metabolic dysfunction or blunted response to starvation. While broadly expressed in all neurons, trsn is transcriptionally upregulated in the heads of flies in response to starvation. Spatially restricted rescue or targeted knockdown localizes trsn function to neurons that produce the tachykinin family neuropeptide Leucokinin. Manipulation of neural activity in Leucokinin neurons revealed these neurons to be required for starvation-induced sleep suppression. Taken together, these findings establish trsn as an essential integrator of sleep and metabolic state, with implications for understanding the neural mechanism underlying sleep disruption in response to environmental perturbation. PMID:27020744

  6. Calcium-regulated exocytosis is required for cell membrane resealing

    PubMed Central

    1995-01-01

    Using confocal microscopy, we visualized exocytosis during membrane resealing in sea urchin eggs and embryos. Upon wounding by a laser beam, both eggs and embryos showed a rapid burst of localized Ca(2+)- regulated exocytosis. The rate of exocytosis was correlated quantitatively with successfully resealing. In embryos, whose activated surfaces must first dock vesicles before fusion, exocytosis and membrane resealing were inhibited by neurotoxins that selectively cleave the SNARE complex proteins, synaptobrevin, SNAP-25, and syntaxin. In eggs, whose cortical vesicles are already docked, vesicles could be reversibly undocked with externally applied stachyose. If cortical vesicles were undocked both exocytosis and plasma membrane resealing were completely inhibited. When cortical vesicles were transiently undocked, exposure to tetanus toxin and botulinum neurotoxin type C1 rendered them no longer competent for resealing, although botulinum neurotoxin type A was still ineffective. Cortical vesicles transiently undocked in the presence of tetanus toxin were subsequently fusion incompetent although to a large extent they retained their ability to redock when stachyose was diluted. We conclude that addition of internal membranes by exocytosis is required and that a SNARE-like complex plays differential roles in vesicle docking and fusion for the repair of disrupted plasma membrane. PMID:8557742

  7. The European "clinical trial" regulation; relationship with the Jardé Act: a Giens workshop.

    PubMed

    Lemaire, François; Marchenay, Brigitte; Chassany, Olivier; Barthélémy, Philippe; Bouzzagou, Mohamed; Comet, Denis; Delval, Cécile; Dubray, Claude; Fouret, Cécile; Frija-Orvoen, Elisabeth; Gambotti, Laetitia; Lamarque, Véronique; d'Orsay, Geneviève; Plattner, Valérie; Sibenaler, Claire; Roux, Jacques; Thoby, Frédérique

    2015-01-01

    In May 2014, the European Union Parliament and Council published a new regulation on clinical trials on medicinal products for human use, which is designed to replace Directive 2001/20/EC. It will not come into effect until 2016. Nevertheless, it is essential to examine its relationship with national legislation, i.e. the Jardé Act, whose implementation has been delayed pending publication of the European regulation. The Giens workshop identified and examined the various issues that this relationship is bound to raise. In particular, it looked at trial methodology assessment procedures, the working relationship between the French National Agency of Drug Safety and Health Products (Agence Nationale de Sécurité du Médicament et des Produits de Santé, ANSM) and ethics committees during the authorization application evaluation phase, review of post-authorization/registration studies on medicinal products and medical devices, and data transparency.

  8. 47 CFR 54.520 - Children's Internet Protection Act certifications required from recipients of discounts under the...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 3 2011-10-01 2011-10-01 false Children's Internet Protection Act... Libraries § 54.520 Children's Internet Protection Act certifications required from recipients of discounts... “technology protection measure” as used in this section, are defined in the Children's Internet Protection...

  9. 47 CFR 54.520 - Children's Internet Protection Act certifications required from recipients of discounts under the...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Children's Internet Protection Act... Libraries § 54.520 Children's Internet Protection Act certifications required from recipients of discounts... “technology protection measure” as used in this section, are defined in the Children's Internet Protection...

  10. 47 CFR 54.520 - Children's Internet Protection Act certifications required from recipients of discounts under the...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 3 2014-10-01 2014-10-01 false Children's Internet Protection Act... Libraries § 54.520 Children's Internet Protection Act certifications required from recipients of discounts... technology that blocks or filters Internet access to the material covered by a certification under...

  11. 47 CFR 54.520 - Children's Internet Protection Act certifications required from recipients of discounts under the...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 3 2013-10-01 2013-10-01 false Children's Internet Protection Act... Libraries § 54.520 Children's Internet Protection Act certifications required from recipients of discounts... technology that blocks or filters Internet access to the material covered by a certification under...

  12. 47 CFR 54.520 - Children's Internet Protection Act certifications required from recipients of discounts under the...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 3 2012-10-01 2012-10-01 false Children's Internet Protection Act... Libraries § 54.520 Children's Internet Protection Act certifications required from recipients of discounts... technology that blocks or filters Internet access to the material covered by a certification under...

  13. Knowledge of the animal welfare act and animal welfare regulations influences attitudes toward animal research.

    PubMed

    Metzger, Mitchell M

    2015-01-01

    Recent public-opinion polls indicate that Americans have shown a decline in support for animal experimentation, and several reports suggest a relationship between people's knowledge of animal welfare regulations and their attitudes toward animal research. Therefore, this study was designed to assess respondent's knowledge of several provisions in the Animal Welfare Act (AWA) and Animal Welfare Regulations (AWR), and determine whether exposure to elements of this legislation would influence an individual's attitudes toward the use of animals in research. A survey was used to assess knowledge of animal research regulations and attitudes toward animal research from a sample of individuals recruited through Amazon's Mechanical Turk crowdsourcing marketplace. Results from study 1 confirmed the hypothesis that respondents had little knowledge of various federal regulations that govern animal research activities. Data from study 2 revealed that exposure to elements of the AWA and AWR influenced participants' attitudes toward the use of animals in research. These results suggest that providing information to the general public about the AWA and AWR that protect laboratory animals from abuse and neglect may help alleviate concerns about using animals in research settings. PMID:25651094

  14. Knowledge of the Animal Welfare Act and Animal Welfare Regulations Influences Attitudes toward Animal Research

    PubMed Central

    2015-01-01

    Recent public-opinion polls indicate that Americans have shown a decline in support for animal experimentation, and several reports suggest a relationship between people's knowledge of animal welfare regulations and their attitudes toward animal research. Therefore, this study was designed to assess respondent's knowledge of several provisions in the Animal Welfare Act (AWA) and Animal Welfare Regulations (AWR), and determine whether exposure to elements of this legislation would influence an individual's attitudes toward the use of animals in research. A survey was used to assess knowledge of animal research regulations and attitudes toward animal research from a sample of individuals recruited through Amazon's Mechanical Turk crowdsourcing marketplace. Results from study 1 confirmed the hypothesis that respondents had little knowledge of various federal regulations that govern animal research activities. Data from study 2 revealed that exposure to elements of the AWA and AWR influenced participants’ attitudes toward the use of animals in research. These results suggest that providing information to the general public about the AWA and AWR that protect laboratory animals from abuse and neglect may help alleviate concerns about using animals in research settings. PMID:25651094

  15. Knowledge of the animal welfare act and animal welfare regulations influences attitudes toward animal research.

    PubMed

    Metzger, Mitchell M

    2015-01-01

    Recent public-opinion polls indicate that Americans have shown a decline in support for animal experimentation, and several reports suggest a relationship between people's knowledge of animal welfare regulations and their attitudes toward animal research. Therefore, this study was designed to assess respondent's knowledge of several provisions in the Animal Welfare Act (AWA) and Animal Welfare Regulations (AWR), and determine whether exposure to elements of this legislation would influence an individual's attitudes toward the use of animals in research. A survey was used to assess knowledge of animal research regulations and attitudes toward animal research from a sample of individuals recruited through Amazon's Mechanical Turk crowdsourcing marketplace. Results from study 1 confirmed the hypothesis that respondents had little knowledge of various federal regulations that govern animal research activities. Data from study 2 revealed that exposure to elements of the AWA and AWR influenced participants' attitudes toward the use of animals in research. These results suggest that providing information to the general public about the AWA and AWR that protect laboratory animals from abuse and neglect may help alleviate concerns about using animals in research settings.

  16. FOXA1 acts upstream of GATA2 and AR in hormonal regulation of gene expression.

    PubMed

    Zhao, J C; Fong, K-W; Jin, H-J; Yang, Y A; Kim, J; Yu, J

    2016-08-18

    Hormonal regulation of gene expression by androgen receptor (AR) is tightly controlled by many transcriptional cofactors, including pioneer factors FOXA1 and GATA2, which, however, exhibit distinct expression patterns and functional roles in prostate cancer. Here, we examined how FOXA1, GATA2 and AR crosstalk and regulate hormone-dependent gene expression in prostate cancer cells. Chromatin immunoprecipitation sequencing analysis revealed that FOXA1 reprograms both AR and GATA2 cistrome by preferably recruiting them to FKHD-containing genomic sites. By contrast, GATA2 is unable to shift AR or FOXA1 to GATA motifs. Rather, GATA2 co-occupancy enhances AR and FOXA1 binding to nearby ARE and FKHD sites, respectively. Similarly, AR increases, but not reprograms, GATA2 and FOXA1 cistromes. Concordantly, GATA2 and AR strongly enhance the transcriptional program of each other, whereas FOXA1 regulates GATA2- and AR-mediated gene expression in a context-dependent manner due to its reprogramming effects. Taken together, our data delineated for the first time the distinct mechanisms by which GATA2 and FOXA1 regulate AR cistrome and suggest that FOXA1 acts upstream of GATA2 and AR in determining hormone-dependent gene expression in prostate cancer.

  17. Global regulation of alternative splicing by adenosine deaminase acting on RNA (ADAR)

    PubMed Central

    Solomon, Oz; Oren, Shirley; Safran, Michal; Deshet-Unger, Naamit; Akiva, Pinchas; Jacob-Hirsch, Jasmine; Cesarkas, Karen; Kabesa, Reut; Amariglio, Ninette; Unger, Ron; Rechavi, Gideon; Eyal, Eran

    2013-01-01

    Alternative mRNA splicing is a major mechanism for gene regulation and transcriptome diversity. Despite the extent of the phenomenon, the regulation and specificity of the splicing machinery are only partially understood. Adenosine-to-inosine (A-to-I) RNA editing of pre-mRNA by ADAR enzymes has been linked to splicing regulation in several cases. Here we used bioinformatics approaches, RNA-seq and exon-specific microarray of ADAR knockdown cells to globally examine how ADAR and its A-to-I RNA editing activity influence alternative mRNA splicing. Although A-to-I RNA editing only rarely targets canonical splicing acceptor, donor, and branch sites, it was found to affect splicing regulatory elements (SREs) within exons. Cassette exons were found to be significantly enriched with A-to-I RNA editing sites compared with constitutive exons. RNA-seq and exon-specific microarray revealed that ADAR knockdown in hepatocarcinoma and myelogenous leukemia cell lines leads to global changes in gene expression, with hundreds of genes changing their splicing patterns in both cell lines. This global change in splicing pattern cannot be explained by putative editing sites alone. Genes showing significant changes in their splicing pattern are frequently involved in RNA processing and splicing activity. Analysis of recently published RNA-seq data from glioblastoma cell lines showed similar results. Our global analysis reveals that ADAR plays a major role in splicing regulation. Although direct editing of the splicing motifs does occur, we suggest it is not likely to be the primary mechanism for ADAR-mediated regulation of alternative splicing. Rather, this regulation is achieved by modulating trans-acting factors involved in the splicing machinery. PMID:23474544

  18. 76 FR 39007 - Native American Graves Protection and Repatriation Act Regulations- Definition of “Indian Tribe”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-05

    ... Office of the Secretary of the Interior 43 CFR Part 10 RIN 1024-AD98 Native American Graves Protection... regulations implementing the Native American Graves Protection and Repatriation Act (NAGPRA) removes the... implementation of the Native American Graves Protection and Repatriation Act, including the issuance...

  19. Confinement regulates complex biochemical networks: initiation of blood clotting by "diffusion acting".

    PubMed

    Shen, Feng; Pompano, Rebecca R; Kastrup, Christian J; Ismagilov, Rustem F

    2009-10-21

    This study shows that environmental confinement strongly affects the activation of nonlinear reaction networks, such as blood coagulation (clotting), by small quantities of activators. Blood coagulation is sensitive to the local concentration of soluble activators, initiating only when the activators surpass a threshold concentration, and therefore is regulated by mass transport phenomena such as flow and diffusion. Here, diffusion was limited by decreasing the size of microfluidic chambers, and it was found that microparticles carrying either the classical stimulus, tissue factor, or a bacterial stimulus, Bacillus cereus, initiated coagulation of human platelet-poor plasma only when confined. A simple analytical argument and numerical model were used to describe the mechanism for this phenomenon: confinement causes diffusible activators to accumulate locally and surpass the threshold concentration. To interpret the results, a dimensionless confinement number, Cn, was used to describe whether a stimulus was confined, and a Damköhler number, Da(2), was used to describe whether a subthreshold stimulus could initiate coagulation. In the context of initiation of coagulation by bacteria, this mechanism can be thought of as "diffusion acting", which is distinct from "diffusion sensing". The ability of confinement and diffusion acting to change the outcome of coagulation suggests that confinement should also regulate other biological "on" and "off" processes that are controlled by thresholds.

  20. 42 CFR 417.478 - Requirements of other laws and regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Requirements of other laws and regulations. 417.478... HEALTH CARE PREPAYMENT PLANS Medicare Contract Requirements § 417.478 Requirements of other laws and regulations. The contract must provide that the HMO or CMP agrees to comply with— (a) The requirements for...

  1. Discovery of a Splicing Regulator Required for Cell Cycle Progression

    SciTech Connect

    Suvorova, Elena S.; Croken, Matthew; Kratzer, Stella; Ting, Li-Min; Conde de Felipe, Magnolia; Balu, Bharath; Markillie, Lye Meng; Weiss, Louis M.; Kim, Kami; White, Michael W.

    2013-02-01

    In the G1 phase of the cell division cycle, eukaryotic cells prepare many of the resources necessary for a new round of growth including renewal of the transcriptional and protein synthetic capacities and building the machinery for chromosome replication. The function of G1 has an early evolutionary origin and is preserved in single and multicellular organisms, although the regulatory mechanisms conducting G1 specific functions are only understood in a few model eukaryotes. Here we describe a new G1 mutant from an ancient family of apicomplexan protozoans. Toxoplasma gondii temperature-sensitive mutant 12-109C6 conditionally arrests in the G1 phase due to a single point mutation in a novel protein containing a single RNA-recognition-motif (TgRRM1). The resulting tyrosine to asparagine amino acid change in TgRRM1 causes severe temperature instability that generates an effective null phenotype for this protein when the mutant is shifted to the restrictive temperature. Orthologs of TgRRM1 are widely conserved in diverse eukaryote lineages, and the human counterpart (RBM42) can functionally replace the missing Toxoplasma factor. Transcriptome studies demonstrate that gene expression is downregulated in the mutant at the restrictive temperature due to a severe defect in splicing that affects both cell cycle and constitutively expressed mRNAs. The interaction of TgRRM1 with factors of the tri-SNP complex (U4/U6 & U5 snRNPs) indicate this factor may be required to assemble an active spliceosome. Thus, the TgRRM1 family of proteins is an unrecognized and evolutionarily conserved class of splicing regulators. This study demonstrates investigations into diverse unicellular eukaryotes, like the Apicomplexa, have the potential to yield new insights into important mechanisms conserved across modern eukaryotic kingdoms.

  2. 77 FR 67366 - Federal Acquisition Regulation; Information Collection; Quality Assurance Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-09

    ... Regulation; Information Collection; Quality Assurance Requirements AGENCY: Department of Defense (DOD... information collection requirement concerning quality assurance requirements. Public comments are particularly... and methodology; ways to enhance the quality, utility, and clarity of the information to be...

  3. Fine regulation of RhoA and Rock is required for skeletal muscle differentiation.

    PubMed

    Castellani, Loriana; Salvati, Erica; Alemà, Stefano; Falcone, Germana

    2006-06-01

    The RhoA GTPase controls a variety of cell functions such as cell motility, cell growth, and gene expression. Previous studies suggested that RhoA mediates signaling inputs that promote skeletal myogenic differentiation. We show here that levels and activity of RhoA protein are down-regulated in both primary avian myoblasts and mouse satellite cells undergoing differentiation, suggesting that a fine regulation of this GTPase is required. In addition, ectopic expression of activated RhoA in primary quail myocytes, but not in mouse myocytes, inhibits accumulation of muscle-specific proteins and cell fusion. By disrupting RhoA signaling with specific inhibitors, we have shown that this GTPase, although required for cell identity in proliferating myoblasts, is not essential for commitment to terminal differentiation and muscle gene expression. Ectopic expression of an activated form of its downstream effector, Rock, impairs differentiation of both avian and mouse myoblasts. Conversely, Rock inhibition with specific inhibitors and small interfering RNA-mediated gene silencing leads to accelerated progression in the lineage and enhanced cell fusion, underscoring a negative regulatory function of Rock in myogenesis. Finally, we have reported that Rock acts independently from RhoA in preventing myoblast exit from the cell cycle and commitment to differentiation and may receive signaling inputs from Raf-1 kinase.

  4. Proper gibberellin localization in vascular tissue is required to regulate adventitious root development in tobacco.

    PubMed

    Niu, Shihui; Li, Zhexin; Yuan, Huwei; Fang, Pan; Chen, Xiaoyang; Li, Wei

    2013-08-01

    Bioactive gibberellins (GAs) are involved in many developmental aspects of the life cycle of plants, acting either directly or through interaction with other hormones. Accumulating evidence suggests that GAs have an important effect on root growth; however, there is currently little information on the specific regulatory mechanism of GAs during adventitious root development. A study was conducted on tobacco (Nicotiana tabacum) plants for altered rates of biosynthesis, catabolism, and GA signalling constitutively or in specific tissues using a transgenic approach. In the present study, PtGA20ox, PtGA2ox1, and PtGAI were overexpressed under the control of the 35S promoter, vascular cambium-specific promoter (LMX5), or root meristem-specific promoter (TobRB7), respectively. Evidence is provided that the precise localization of bioactive GA in the stem but not in the roots is required to regulate adventitious root development in tobacco. High levels of GA negatively regulate the early initiation step of root formation through interactions with auxin, while a proper and mobile GA signal is required for the emergence and subsequent long-term elongation of established primordia. The results demonstrated that GAs have an inhibitory effect on adventitious root formation but a stimulatory effect on root elongation. PMID:23918971

  5. Compliance with the Clean Air Act Title VI Stratospheric Ozone Protection Program requirements at U.S. DOE Oak Ridge Reservation Facilities

    SciTech Connect

    Humphreys, M.P.; Atkins, E.M.

    1999-07-01

    The Title VI Stratospheric Ozone Protection Program of the Clean Air Act (CAA) requires promulgation of regulations to reduce and prevent damage to the earth's protective ozone layer. Regulations pursuant to Title VI of the CAA are promulgated in the Code of Federal Regulations (CFR) at Title 40 CFR, Part 822. The regulations include ambitious production phaseout schedules for ozone depleting substances (ODS) including chlorofluorocarbons (CFCs), hydrochlorofluorocarbons (HCFCs), halons, carbon tetrachloride, and methyl chloroform under 40 CFR 82, Subpart A. The regulations also include requirements for recycling and emissions reduction during the servicing of refrigeration equipment and technician certification requirements under Subpart F; provisions for servicing of motor vehicle air conditioners under Subpart B; a ban on nonessential products containing Class 1 ODS under Subpart C; restrictions on Federal procurement of ODS under Subpart D; labeling of products using ODS under Subpart E; and the Significant New Alternatives Policy Program under Subpart G. This paper will provide details of initiatives undertaken at US Department of Energy (DOE) Oak Ridge Reservation (ORR) Facilities for implementation of requirements under the Title VI Stratospheric Ozone Protection Program. The Stratospheric Ozone Protection Plans include internal DOE requirements for: (1) maintenance of ODS inventories; (2) ODS procurement practices; (3) servicing of refrigeration and air conditioning equipment; (4) required equipment modifications or replacement; (5) technician certification training; (6) labeling of products containing ODS; (7) substitution of chlorinated solvents; and (8) replacement of halon fire protection systems. The plans also require establishment of administrative control systems which assure that compliance is achieved and maintained as the regulations continue to develop and become effective.

  6. Abelson kinase acts as a robust, multifunctional scaffold in regulating embryonic morphogenesis

    PubMed Central

    Rogers, Edward M.; Spracklen, Andrew J.; Bilancia, Colleen G.; Sumigray, Kaelyn D.; Allred, S. Colby; Nowotarski, Stephanie H.; Schaefer, Kristina N.; Ritchie, Benjamin J.; Peifer, Mark

    2016-01-01

    Abelson family kinases (Abls) are key regulators of cell behavior and the cytoskeleton during development and in leukemia. Abl’s SH3, SH2, and tyrosine kinase domains are joined via a linker to an F-actin–binding domain (FABD). Research on Abl’s roles in cell culture led to several hypotheses for its mechanism of action: 1) Abl phosphorylates other proteins, modulating their activity, 2) Abl directly regulates the cytoskeleton via its cytoskeletal interaction domains, and/or 3) Abl is a scaffold for a signaling complex. The importance of these roles during normal development remains untested. We tested these mechanistic hypotheses during Drosophila morphogenesis using a series of mutants to examine Abl’s many cell biological roles. Strikingly, Abl lacking the FABD fully rescued morphogenesis, cell shape change, actin regulation, and viability, whereas kinase-dead Abl, although reduced in function, retained substantial rescuing ability in some but not all Abl functions. We also tested the function of four conserved motifs in the linker region, revealing a key role for a conserved PXXP motif known to bind Crk and Abi. We propose that Abl acts as a robust multidomain scaffold with different protein motifs and activities contributing differentially to diverse cellular behaviors. PMID:27385341

  7. 78 FR 19467 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement (DFARS...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-01

    ... Defense Acquisition Regulations System Information Collection Requirement; Defense Federal Acquisition Regulation Supplement (DFARS); DoD Pilot Mentor-Prot g Program AGENCY: Defense Acquisition Regulations System... approved information collection requirement. SUMMARY: In compliance with Section 3506(c)(2)(A) of...

  8. 75 FR 15388 - Amendment to the International Traffic in Arms Regulations: Removing Requirement for Prior...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-29

    ... Parts 124, 126, and 129 RIN 1400-AC62 Amendment to the International Traffic in Arms Regulations... amending the International Traffic in Arms Regulations (ITAR) to remove the requirements for prior approval... International Traffic in Arms Regulations (ITAR) at 22 CFR 123.16, to require Department of State...

  9. 7 CFR 318.13-3 - General requirements for all regulated articles.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 5 2011-01-01 2011-01-01 false General requirements for all regulated articles. 318.13-3 Section 318.13-3 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND... NOTICES Regulated Articles From Hawaii and the Territories § 318.13-3 General requirements for...

  10. 12 CFR 335.901 - Delegation of authority to act on matters with respect to disclosure laws and regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... respect to disclosure laws and regulations. 335.901 Section 335.901 Banks and Banking FEDERAL DEPOSIT... § 335.901 Delegation of authority to act on matters with respect to disclosure laws and regulations. (a... Supervision and Consumer Protection (DSC), and where confirmed in writing by the director, to a...

  11. 49 CFR 171.26 - Additional requirements for the use of the IAEA Regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Additional requirements for the use of the IAEA Regulations. 171.26 Section 171.26 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS GENERAL INFORMATION, REGULATIONS,...

  12. Consequences of proposed changes to Clean Water Act thermal discharge requirements

    SciTech Connect

    Veil, J.A.; Moses, D.O.

    1995-12-31

    This paper summarizes three studies that examined the economic and environmental impact on the power industry of (1) limiting thermal mixing zones to 1,000 feet, and (2) eliminating the Clean Water Act (CWA) {section}316(1) variance. Both of these proposed changes were included in S. 1081, a 1991 Senate bill to reauthorize the CWA. The bill would not have provided for grandfathering plants already using the variance or mixing zones larger than 1000 feet. Each of the two changes to the existing thermal discharge requirements were independently evaluated. Power companies were asked what they would do if these two changes were imposed. Most plants affected by the proposed changes would retrofit cooling towers and some would retrofit diffusers. Assuming that all affected plants would proportionally follow the same options as the surveyed plants, the estimated capital cost of retrofitting cooling towers or diffusers at all affected plants ranges from $21.4 to 24.4 billion. Both cooling towers and diffusers exert a 1%-5.8% energy penalty on a plant`s output. Consequently, the power companies must generate additional power if they install those technologies. The estimated cost of the additional power ranges from $10 to 18.4 billion over 20 years. Generation of the extra power would emit over 8 million tons per year of additional carbon dioxide. Operation of the new cooling towers would cause more than 1.5 million gallons per minute of additional evaporation. Neither the restricted mixing zone size nor the elimination of the {section}316(1) variance was adopted into law. More recent proposed changes to the Clean Water Act have not included either of these provisions, but in the future, other Congresses might attempt to reintroduce these types of changes.

  13. Enhancer of zeste acts as a major developmental regulator of Ciona intestinalis embryogenesis

    PubMed Central

    Le Goff, Emilie; Martinand-Mari, Camille; Martin, Marianne; Feuillard, Jérôme; Boublik, Yvan; Godefroy, Nelly; Mangeat, Paul; Baghdiguian, Stephen; Cavalli, Giacomo

    2015-01-01

    ABSTRACT The paradigm of developmental regulation by Polycomb group (PcG) proteins posits that they maintain silencing outside the spatial expression domains of their target genes, particularly of Hox genes, starting from mid embryogenesis. The Enhancer of zeste [E(z)] PcG protein is the catalytic subunit of the PRC2 complex, which silences its targets via deposition of the H3K27me3 mark. Here, we studied the ascidian Ciona intestinalis counterpart of E(z). Ci-E(z) is detected by immunohistochemistry as soon as the 2- and 4-cell stages as a cytoplasmic form and becomes exclusively nuclear thereafter, whereas the H3K27me3 mark is detected starting from the gastrula stage and later. Morpholino invalidation of Ci-E(z) leads to the total disappearance of both Ci-E(z) protein and its H3K27me3 mark. Ci-E(z) morphants display a severe phenotype. Strikingly, the earliest defects occur at the 4-cell stage with the dysregulation of cell positioning and mitotic impairment. At later stages, Ci-E(z)-deficient embryos are affected by terminal differentiation defects of neural, epidermal and muscle tissues, by the failure to form a notochord and by the absence of caudal nerve. These major phenotypic defects are specifically rescued by injection of a morpholino-resistant Ci-E(z) mRNA, which restores expression of Ci-E(z) protein and re-deposition of the H3K27me3 mark. As observed by qPCR analyses, Ci-E(z) invalidation leads to the early derepression of tissue-specific developmental genes, whereas late-acting developmental genes are generally down-regulated. Altogether, our results suggest that Ci-E(z) plays a major role during embryonic development in Ciona intestinalis by silencing early-acting developmental genes in a Hox-independent manner. PMID:26276097

  14. 78 FR 63462 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-24

    ... organizational conflicts of interest arising in a systems engineering and technical assistance contract for an... Defense Acquisition Regulations System Information Collection Requirement; Defense Federal Acquisition...: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Notice and request...

  15. 76 FR 35424 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-17

    ... Regulation Supplement; Acquisition of Information Technology AGENCY: Defense Acquisition Regulations System... technology. The Office of Management and Budget (OMB) has approved this information collection requirement... Supplement (DFARS) Part 239, Acquisition of Information Technology, and the associated clauses at DFARS...

  16. 75 FR 68333 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; DFARS...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-05

    ... Regulation Supplement; DFARS Appendix F, Material Inspection and Receiving Report (OMB Control Number 0704... Acquisition Regulation Supplement (DFARS) Appendix F, Material Inspection and Receiving Report; DD Form 250... Information Collection This information collection includes the requirements of DFARS Appendix F,...

  17. Federal environmental and occupational toxicology regulations and reporting requirements: a practical approach to what the medical toxicologist needs to know, part 1.

    PubMed

    Schwartz, Michael D; Dell'Aglio, Damon M; Nickle, Richard; Hornsby-Myers, Jennifer

    2014-09-01

    Toxicologists are often called upon to assist in environmental, industrial, occupational and public health assessments. Accordingly, medical toxicologists may find it prudent to be aware of applicable federal toxicological regulations and reporting requirements and of the roles of relevant federal agencies. These regulations are numerous, complex, and have evolved and expanded over time, making it difficult for toxicologists to sustain a current knowledge base. This article reviews the pertinent federal toxicological reporting requirements with regard to the Toxic Substances Control Act (TSCA), the Atomic Energy Act (AEA), the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), the Resource Conservation and Recovery Act (RCRA), the Clean Air Act, the Clean Water Act, the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), the Emergency Planning and Community Right to Know Act (EPCRA), the Occupational Safety and Health Act, the Department of Transportation, and information about the National Response Center. We reference internet-based government resources and offer direct links to applicable websites in an attempt to offer rapid and current sources of practical information. The format of the article is a series of hypothetical scenarios followed by commentary. Discussions of the Safe Drinking Water Act, the Food, Drug, and Cosmetic Act, and the Dietary Supplement Health and Education Act are beyond the scope of this paper. For those desiring a more in-depth discussion of the relevant federal environmental laws and statutes and applicable case law, the reader is directed to resources such as the Environmental Law Handbook, the websites of individual laws found at www.epa.gov and the decisions of individual courts of appeal. It is our hope that this article provides not only useful practical information for the practicing toxicologist but also serves as a key reference for medical toxicology core content on environmental laws and

  18. Federal environmental and occupational toxicology regulations and reporting requirements: a practical approach to what the medical toxicologist needs to know, part 2.

    PubMed

    Schwartz, Michael D; Dell'Aglio, Damon M; Nickle, Richard; Hornsby-Myers, Jennifer

    2014-12-01

    Toxicologists are often called upon to assist in environmental, industrial, occupational and public health assessments. Accordingly, medical toxicologists may find it prudent to be aware of applicable federal toxicological regulations and reporting requirements and of the roles of relevant federal agencies. These regulations are numerous, complex, and have evolved and expanded over time, making it difficult for toxicologists to sustain a current knowledge base. This article reviews the pertinent federal toxicological reporting requirements with regards to the Toxic Substances Control Act (TSCA), the Atomic Energy Act (AEA), the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), the Resource Conservation and Recovery Act (RCRA), the Clean Air Act, the Clean Water Act, the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), the Emergency Planning and Community Right to Know Act (EPCRA), the Occupational Safety and Health Act, the Department of Transportation, and information about the National Response Center. We reference internet-based government resources and offer direct links to applicable websites in an attempt to offer rapid and current sources of practical information. The format of the article is a series of hypothetical scenarios followed by commentary. Discussions of the Safe Drinking Water Act and the Food, Drug, and Cosmetic Act and the Dietary Supplement Health and Education Act are beyond the scope of this paper. For those desiring a more in depth discussion of the relevant federal environmental laws and statutes, and applicable case law, the reader is directed to resources such as the Environmental Law Handbook, the websites of individual laws found at www.epa.gov and the decisions of individual courts of appeal. It is our hope that this article provides not only useful practical information for the practicing toxicologist, but also serves as a key reference for Medical Toxicology core content on environmental

  19. Federal environmental and occupational toxicology regulations and reporting requirements: a practical approach to what the medical toxicologist needs to know, part 2.

    PubMed

    Schwartz, Michael D; Dell'Aglio, Damon M; Nickle, Richard; Hornsby-Myers, Jennifer

    2014-12-01

    Toxicologists are often called upon to assist in environmental, industrial, occupational and public health assessments. Accordingly, medical toxicologists may find it prudent to be aware of applicable federal toxicological regulations and reporting requirements and of the roles of relevant federal agencies. These regulations are numerous, complex, and have evolved and expanded over time, making it difficult for toxicologists to sustain a current knowledge base. This article reviews the pertinent federal toxicological reporting requirements with regards to the Toxic Substances Control Act (TSCA), the Atomic Energy Act (AEA), the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), the Resource Conservation and Recovery Act (RCRA), the Clean Air Act, the Clean Water Act, the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), the Emergency Planning and Community Right to Know Act (EPCRA), the Occupational Safety and Health Act, the Department of Transportation, and information about the National Response Center. We reference internet-based government resources and offer direct links to applicable websites in an attempt to offer rapid and current sources of practical information. The format of the article is a series of hypothetical scenarios followed by commentary. Discussions of the Safe Drinking Water Act and the Food, Drug, and Cosmetic Act and the Dietary Supplement Health and Education Act are beyond the scope of this paper. For those desiring a more in depth discussion of the relevant federal environmental laws and statutes, and applicable case law, the reader is directed to resources such as the Environmental Law Handbook, the websites of individual laws found at www.epa.gov and the decisions of individual courts of appeal. It is our hope that this article provides not only useful practical information for the practicing toxicologist, but also serves as a key reference for Medical Toxicology core content on environmental

  20. Federal environmental and occupational toxicology regulations and reporting requirements: a practical approach to what the medical toxicologist needs to know, part 1.

    PubMed

    Schwartz, Michael D; Dell'Aglio, Damon M; Nickle, Richard; Hornsby-Myers, Jennifer

    2014-09-01

    Toxicologists are often called upon to assist in environmental, industrial, occupational and public health assessments. Accordingly, medical toxicologists may find it prudent to be aware of applicable federal toxicological regulations and reporting requirements and of the roles of relevant federal agencies. These regulations are numerous, complex, and have evolved and expanded over time, making it difficult for toxicologists to sustain a current knowledge base. This article reviews the pertinent federal toxicological reporting requirements with regard to the Toxic Substances Control Act (TSCA), the Atomic Energy Act (AEA), the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), the Resource Conservation and Recovery Act (RCRA), the Clean Air Act, the Clean Water Act, the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), the Emergency Planning and Community Right to Know Act (EPCRA), the Occupational Safety and Health Act, the Department of Transportation, and information about the National Response Center. We reference internet-based government resources and offer direct links to applicable websites in an attempt to offer rapid and current sources of practical information. The format of the article is a series of hypothetical scenarios followed by commentary. Discussions of the Safe Drinking Water Act, the Food, Drug, and Cosmetic Act, and the Dietary Supplement Health and Education Act are beyond the scope of this paper. For those desiring a more in-depth discussion of the relevant federal environmental laws and statutes and applicable case law, the reader is directed to resources such as the Environmental Law Handbook, the websites of individual laws found at www.epa.gov and the decisions of individual courts of appeal. It is our hope that this article provides not only useful practical information for the practicing toxicologist but also serves as a key reference for medical toxicology core content on environmental laws and

  1. 45 CFR 1356.40 - Adoption assistance program: Administrative requirements to implement section 473 of the Act.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SERVICES THE ADMINISTRATION ON CHILDREN, YOUTH AND FAMILIES, FOSTER CARE MAINTENANCE PAYMENTS, ADOPTION ASSISTANCE, AND CHILD AND FAMILY SERVICES REQUIREMENTS APPLICABLE TO TITLE IV-E § 1356.40 Adoption assistance... requirements of section 475(3) of the Act and must: (1) Be signed and in effect at the time of or prior to...

  2. 45 CFR 1356.40 - Adoption assistance program: Administrative requirements to implement section 473 of the Act.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... SERVICES THE ADMINISTRATION ON CHILDREN, YOUTH AND FAMILIES, FOSTER CARE MAINTENANCE PAYMENTS, ADOPTION ASSISTANCE, AND CHILD AND FAMILY SERVICES REQUIREMENTS APPLICABLE TO TITLE IV-E § 1356.40 Adoption assistance... requirements of section 475(3) of the Act and must: (1) Be signed and in effect at the time of or prior to...

  3. 45 CFR 1356.40 - Adoption assistance program: Administrative requirements to implement section 473 of the Act.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SERVICES THE ADMINISTRATION ON CHILDREN, YOUTH AND FAMILIES, FOSTER CARE MAINTENANCE PAYMENTS, ADOPTION ASSISTANCE, AND CHILD AND FAMILY SERVICES REQUIREMENTS APPLICABLE TO TITLE IV-E § 1356.40 Adoption assistance... requirements of section 475(3) of the Act and must: (1) Be signed and in effect at the time of or prior to...

  4. 15 CFR 744.11 - License requirements that apply to entities acting contrary to the national security or foreign...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... entities acting contrary to the national security or foreign policy interests of the United States. 744.11...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY... national security or foreign policy interests of the United States. BIS may impose foreign policy...

  5. 15 CFR 744.11 - License requirements that apply to entities acting contrary to the national security or foreign...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... entities acting contrary to the national security or foreign policy interests of the United States. 744.11...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY... national security or foreign policy interests of the United States. BIS may impose foreign policy...

  6. 15 CFR 744.11 - License requirements that apply to entities acting contrary to the national security or foreign...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... entities acting contrary to the national security or foreign policy interests of the United States. 744.11...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY... national security or foreign policy interests of the United States. BIS may impose foreign policy...

  7. Genome-wide prediction of cis-acting RNA elements regulating tissue-specific pre-mRNA alternative splicing

    PubMed Central

    Wang, Xin; Wang, Kejun; Radovich, Milan; Wang, Yue; Wang, Guohua; Feng, Weixing; Sanford, Jeremy R; Liu, Yunlong

    2009-01-01

    Background Human genes undergo various patterns of pre-mRNA splicing across different tissues. Such variation is primarily regulated by trans-acting factors that bind on exonic and intronic cis-acting RNA elements (CAEs). Here we report a computational method to mechanistically identify cis-acting RNA elements that contribute to the tissue-specific alternative splicing pattern. This method is an extension of our previous model, SplicingModeler, which predicts the significant CAEs that contribute to the splicing differences between two tissues. In this study, we introduce tissue-specific functional levels estimation step, which allows evaluating regulatory functions of predicted CAEs that are involved in more than two tissues. Results Using a publicly available Affymetrix Genechip® Human Exon Array dataset, our method identifies 652 cis-acting RNA elements (CAEs) across 11 human tissues. About one third of predicted CAEs can be mapped to the known RBP (RNA binding protein) binding sites or match with other predicted exonic splicing regulator databases. Interestingly, the vast majority of predicted CAEs are in intronic regulatory regions. A noticeable exception is that many exonic elements are found to regulate the alternative splicing between cerebellum and testes. Most identified elements are found to contribute to the alternative splicing between two tissues, while some are important in multiple tissues. This suggests that genome-wide alternative splicing patterns are regulated by a combination of tissue-specific cis-acting elements and "general elements" whose functional activities are important but differ across multiple tissues. Conclusion In this study, we present a model-based computational approach to identify potential cis-acting RNA elements by considering the exon splicing variation as the combinatorial effects of multiple cis-acting regulators. This methodology provides a novel evaluation on the functional levels of cis-acting RNA elements by estimating

  8. 78 FR 25795 - Contractor Legal Management Requirements; Acquisition Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-03

    ... Federal Register on August 31, 1994 (59 FR 44981). The interim Acquisition Letter was finalized as a Policy Statement on April 3, 1996 (61 FR 14763). This Policy Statement was followed by a formal... Regulations with an effective date of April 23, 2001 (66 FR 4616, 66 FR 19717). After a decade operating...

  9. Flavonoids act as negative regulators of auxin transport in vivo in arabidopsis

    NASA Technical Reports Server (NTRS)

    Brown, D. E.; Rashotte, A. M.; Murphy, A. S.; Normanly, J.; Tague, B. W.; Peer, W. A.; Taiz, L.; Muday, G. K.

    2001-01-01

    Polar transport of the plant hormone auxin controls many aspects of plant growth and development. A number of synthetic compounds have been shown to block the process of auxin transport by inhibition of the auxin efflux carrier complex. These synthetic auxin transport inhibitors may act by mimicking endogenous molecules. Flavonoids, a class of secondary plant metabolic compounds, have been suggested to be auxin transport inhibitors based on their in vitro activity. The hypothesis that flavonoids regulate auxin transport in vivo was tested in Arabidopsis by comparing wild-type (WT) and transparent testa (tt4) plants with a mutation in the gene encoding the first enzyme in flavonoid biosynthesis, chalcone synthase. In a comparison between tt4 and WT plants, phenotypic differences were observed, including three times as many secondary inflorescence stems, reduced plant height, decreased stem diameter, and increased secondary root development. Growth of WT Arabidopsis plants on naringenin, a biosynthetic precursor to those flavonoids with auxin transport inhibitor activity in vitro, leads to a reduction in root growth and gravitropism, similar to the effects of synthetic auxin transport inhibitors. Analyses of auxin transport in the inflorescence and hypocotyl of independent tt4 alleles indicate that auxin transport is elevated in plants with a tt4 mutation. In hypocotyls of tt4, this elevated transport is reversed when flavonoids are synthesized by growth of plants on the flavonoid precursor, naringenin. These results are consistent with a role for flavonoids as endogenous regulators of auxin transport.

  10. Progesterone acts via progesterone receptors A and B to regulate breast cancer resistance protein expression.

    PubMed

    Vore, Mary; Leggas, Markos

    2008-03-01

    The breast cancer resistance protein (BCRP; ABCG2) is an ATP-dependent efflux multidrug transporter that belongs to the G family of half-transporters that consist of six transmembrane-spanning domains and must homodimerize to form the active membrane transporter. It is expressed in the apical plasma membrane domain of the small intestine, endothelium, and liver, where it has been shown to play an important role in limiting drug absorption and distribution and in enhancing drug clearance, respectively. BCRP is also expressed in the apical membrane of mammary alveolar epithelia, where it mediates efflux of substrates into milk, and in the placental syncytiotro-phoblasts, where it reduces fetal exposure to these substrates. BCRP substrates include numerous drugs (topotecan, nitrofurantoin, cimetidine) as well as food carcinogens (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and the vitamins riboflavin and folic acid. BCRP expression is regulated by a number of nuclear transcription factors, including the peroxisome proliferator-activated receptor-gamma and Hif-1. This issue of Molecular Pharmacology includes a study (p. 845) now conclusively demonstrating that progesterone acts via the progesterone A and B receptors to regulate BCRP expression in a placental cell line.

  11. PKR is activated by cellular dsRNAs during mitosis and acts as a mitotic regulator

    PubMed Central

    Kim, Yoosik; Lee, Jung Hyun; Park, Jong-Eun; Cho, Jun; Yi, Hyerim; Kim, V. Narry

    2014-01-01

    dsRNA-dependent protein kinase R (PKR) is a ubiquitously expressed enzyme well known for its roles in immune response. Upon binding to viral dsRNA, PKR undergoes autophosphorylation, and the phosphorylated PKR (pPKR) regulates translation and multiple signaling pathways in infected cells. Here, we found that PKR is activated in uninfected cells, specifically during mitosis, by binding to dsRNAs formed by inverted Alu repeats (IRAlus). While PKR and IRAlu-containing RNAs are segregated in the cytosol and nucleus of interphase cells, respectively, they interact during mitosis when nuclear structure is disrupted. Once phosphorylated, PKR suppresses global translation by phosphorylating the α subunit of eukaryotic initiation factor 2 (eIF2α). In addition, pPKR acts as an upstream kinase for c-Jun N-terminal kinase and regulates the levels of multiple mitotic factors such as CYCLINS A and B and POLO-LIKE KINASE 1 and phosphorylation of HISTONE H3. Disruption of PKR activation via RNAi or expression of a transdominant-negative mutant leads to misregulation of the mitotic factors, delay in mitotic progression, and defects in cytokinesis. Our study unveils a novel function of PKR and endogenous dsRNAs as signaling molecules during the mitosis of uninfected cells. PMID:24939934

  12. PKR is activated by cellular dsRNAs during mitosis and acts as a mitotic regulator.

    PubMed

    Kim, Yoosik; Lee, Jung Hyun; Park, Jong-Eun; Cho, Jun; Yi, Hyerim; Kim, V Narry

    2014-06-15

    dsRNA-dependent protein kinase R (PKR) is a ubiquitously expressed enzyme well known for its roles in immune response. Upon binding to viral dsRNA, PKR undergoes autophosphorylation, and the phosphorylated PKR (pPKR) regulates translation and multiple signaling pathways in infected cells. Here, we found that PKR is activated in uninfected cells, specifically during mitosis, by binding to dsRNAs formed by inverted Alu repeats (IRAlus). While PKR and IRAlu-containing RNAs are segregated in the cytosol and nucleus of interphase cells, respectively, they interact during mitosis when nuclear structure is disrupted. Once phosphorylated, PKR suppresses global translation by phosphorylating the α subunit of eukaryotic initiation factor 2 (eIF2α). In addition, pPKR acts as an upstream kinase for c-Jun N-terminal kinase and regulates the levels of multiple mitotic factors such as cyclins A and B and Polo-like kinase 1 and phosphorylation of histone H3. Disruption of PKR activation via RNAi or expression of a transdominant-negative mutant leads to misregulation of the mitotic factors, delay in mitotic progression, and defects in cytokinesis. Our study unveils a novel function of PKR and endogenous dsRNAs as signaling molecules during the mitosis of uninfected cells.

  13. Neuropeptide Y acts in the paraventricular nucleus to suppress sympathetic nerve activity and its baroreflex regulation.

    PubMed

    Cassaglia, Priscila A; Shi, Zhigang; Li, Baoxin; Reis, Wagner L; Clute-Reinig, Nicholas M; Stern, Javier E; Brooks, Virginia L

    2014-04-01

    Neuropeptide Y (NPY), a brain neuromodulator that has been strongly implicated in the regulation of energy balance, also acts centrally to inhibit sympathetic nerve activity (SNA); however, the site and mechanism of action are unknown. In chloralose-anaesthetized female rats, nanoinjection of NPY into the paraventricular nucleus of the hypothalamus (PVN) dose-dependently suppressed lumbar SNA (LSNA) and its baroreflex regulation, and these effects were blocked by prior inhibition of NPY Y1 or Y5 receptors. Moreover, PVN injection of Y1 and Y5 receptor antagonists in otherwise untreated rats increased basal and baroreflex control of LSNA, indicating that endogenous NPY tonically inhibits PVN presympathetic neurons. The sympathoexcitation following blockade of PVN NPY inhibition was eliminated by prior PVN nanoinjection of the melanocortin 3/4 receptor inhibitor SHU9119. Moreover, presympathetic neurons, identified immunohistochemically using cholera toxin b neuronal tract tracing from the rostral ventrolateral medulla (RVLM), express NPY Y1 receptor immunoreactivity, and patch-clamp recordings revealed that both NPY and α-melanocyte-stimulating hormone (α-MSH) inhibit and stimulate, respectively, PVN-RVLM neurons. Collectively, these data suggest that PVN NPY inputs converge with α-MSH to influence presympathetic neurons. Together these results identify endogenous NPY as a novel and potent inhibitory neuromodulator within the PVN that may contribute to changes in SNA that occur in states associated with altered energy balance, such as obesity and pregnancy. PMID:24535439

  14. Flavonoids Act as Negative Regulators of Auxin Transport in Vivo in Arabidopsis1

    PubMed Central

    Brown, Dana E.; Rashotte, Aaron M.; Murphy, Angus S.; Normanly, Jennifer; Tague, Brian W.; Peer, Wendy A.; Taiz, Lincoln; Muday, Gloria K.

    2001-01-01

    Polar transport of the plant hormone auxin controls many aspects of plant growth and development. A number of synthetic compounds have been shown to block the process of auxin transport by inhibition of the auxin efflux carrier complex. These synthetic auxin transport inhibitors may act by mimicking endogenous molecules. Flavonoids, a class of secondary plant metabolic compounds, have been suggested to be auxin transport inhibitors based on their in vitro activity. The hypothesis that flavonoids regulate auxin transport in vivo was tested in Arabidopsis by comparing wild-type (WT) and transparent testa (tt4) plants with a mutation in the gene encoding the first enzyme in flavonoid biosynthesis, chalcone synthase. In a comparison between tt4 and WT plants, phenotypic differences were observed, including three times as many secondary inflorescence stems, reduced plant height, decreased stem diameter, and increased secondary root development. Growth of WT Arabidopsis plants on naringenin, a biosynthetic precursor to those flavonoids with auxin transport inhibitor activity in vitro, leads to a reduction in root growth and gravitropism, similar to the effects of synthetic auxin transport inhibitors. Analyses of auxin transport in the inflorescence and hypocotyl of independent tt4 alleles indicate that auxin transport is elevated in plants with a tt4 mutation. In hypocotyls of tt4, this elevated transport is reversed when flavonoids are synthesized by growth of plants on the flavonoid precursor, naringenin. These results are consistent with a role for flavonoids as endogenous regulators of auxin transport. PMID:11402184

  15. Intergovernmental relations inherent in the Energy Management Partnership Act: a workshop on information requirements

    SciTech Connect

    Hoop, W.J.; Edelson, E.

    1980-02-01

    This paper summarizes the results of the first of three workshops that were planned to assess the information needed by the Office of Conservation and Solar Energy (CS) to effectively evaluate the pending Energy Management Partnership Act (EMPA); the workshop concentrated on issues of the EMPA hierarchical partnership. The approach utilized offers two major benefits to CS. First, by considering the problem of program evaluation while EMPA is still in the planning stage, this study identifies any baseline information that should be collected prior to implementation of EMPA, and also provides CS with the opportunity to include evaluation considerations in the operating guidelines for the program. Second, by identifying the potential problems and benefits inherent in EMPA and then identifying the information necessary to evaluate these problems and benefits, information requirements tied to the reasons for needing that information are generated, rather than a long unrelated laundry list of information requirements. Drafting of EMPA is not yet complete. When the term EMPA is used here, it refers to a set of bills that are presently being melded together. The original EMPA bill, which originated in DOE, was designed to expand the role of state and local governments in achieving national energy goals. Specifically, EMPA would provide a total of $110 million annually to state and local governments over a five year period to (1) develop an overall state energy plan, (2) consolidate three existing federal energy grant programs, (3) allow the secretary to fund directly innovative projects at the local level, and (4) provide additional assistance to states to cover the administrative costs of existing energy programs. Other bills, which may be passed in conjuncttion with EMPA or incorporated into EMPA, place additional emphasis on the local level by allocating as much as $400 million annually to local governments.

  16. Interdomain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis.

    PubMed

    Kachaner, David; Pinson, Xavier; El Kadhi, Khaled Ben; Normandin, Karine; Talje, Lama; Lavoie, Hugo; Lépine, Guillaume; Carréno, Sébastien; Kwok, Benjamin H; Hickson, Gilles R; Archambault, Vincent

    2014-10-27

    Drosophila melanogaster Polo and its human orthologue Polo-like kinase 1 fulfill essential roles during cell division. Members of the Polo-like kinase (Plk) family contain an N-terminal kinase domain (KD) and a C-terminal Polo-Box domain (PBD), which mediates protein interactions. How Plks are regulated in cytokinesis is poorly understood. Here we show that phosphorylation of Polo by Aurora B is required for cytokinesis. This phosphorylation in the activation loop of the KD promotes the dissociation of Polo from the PBD-bound microtubule-associated protein Map205, which acts as an allosteric inhibitor of Polo kinase activity. This mechanism allows the release of active Polo from microtubules of the central spindle and its recruitment to the site of cytokinesis. Failure in Polo phosphorylation results in both early and late cytokinesis defects. Importantly, the antagonistic regulation of Polo by Aurora B and Map205 in cytokinesis reveals that interdomain allosteric mechanisms can play important roles in controlling the cellular functions of Plks.

  17. Decree No. 0784 of 18 April 1989 regulating, in part, Act 21 of 1982 and Act 71 of 1988.

    PubMed

    1989-01-01

    This Colombian Decree regulates certain aspects of the system of family allowances. Among other things, it provides that allowances can be granted in terms of food, clothing, school scholarships, textbooks, drugs, and other substitutes for money. Further provisions of the Decree deal with the definition of persons affiliated to the regime, booklets certifying affiliation, family service subsidies, and financing. PMID:12344547

  18. Decree No. 0784 of 18 April 1989 regulating, in part, Act 21 of 1982 and Act 71 of 1988.

    PubMed

    1989-01-01

    This Colombian Decree regulates certain aspects of the system of family allowances. Among other things, it provides that allowances can be granted in terms of food, clothing, school scholarships, textbooks, drugs, and other substitutes for money. Further provisions of the Decree deal with the definition of persons affiliated to the regime, booklets certifying affiliation, family service subsidies, and financing.

  19. Integrating NEPA (National Environmental Policy Act) and CERCLA (Comprehensive Environmental Response, Compensation, and Liability Act) requirements during remedial responses at DOE facilities

    SciTech Connect

    Levine, M.B.; Smith, E.D.; Sharples, F.E.; Eddlemon, G.K.

    1990-07-01

    US Department of Energy (DOE) Order 5400.4, issued October 6, 1989, calls for integrating the requirements of the National Environmental Policy Act (NEPA) with those of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) for DOE remedial actions under CERCLA. CERCLA requires that decisions on site remediation be made through a formal process called a Remedial Investigation/Feasibility Study (RI/FS). According to the DOE order, integration is to be accomplished by conducting the NEPA and CERCLA environmental planning and review procedures concurrently. The primary instrument for integrating the processes is to be the RI/FS process, which will be supplemented as needed to meet the procedural and documentational requirements of NEPA. The final product of the integrated process will be a single, integrated set of documents; namely, an RI report and an FS-EIS that satisfy the requirements of both NEPA and CERCLA. The contents of the report include (1) an overview and comparison of the requirements of the two processes; (2) descriptions of the major tasks included in the integrated RI/FS-EIS process; (3) recommended contents for integrated RI/FS-EIS documents; and (4)a discussion of some potential problems in integrating NEPA and CERCLA that fall outisde the scope of the RI/FS-EIS process, with suggestions for resolving some of these problems. 15 refs.

  20. Polyadenylation in Rice Tungro Bacilliform Virus: cis-Acting Signals and Regulation

    PubMed Central

    Rothnie, Helen M.; Chen, Gang; Fütterer, Johannes; Hohn, Thomas

    2001-01-01

    The polyadenylation signal of rice tungro bacilliform virus (RTBV) was characterized by mutational and deletion analysis. The cis-acting signals required to direct polyadenylation conformed to what is known for plant poly(A) signals in general and were very similar to those of the related cauliflower mosaic virus. Processing was directed by a canonical AAUAAA poly(A) signal, an upstream UG-rich region considerably enhanced processing efficiency, and sequences downstream of the cleavage site were not required. When present at the end of a transcription unit, the cis-acting signals for 3′-end processing were highly efficient in both monocot (rice) and dicot (Nicotiana plumbaginifolia) protoplasts. In a promoter-proximal position, as in the viral genome, the signal was also efficiently processed in rice protoplasts, giving rise to an abundant “short-stop” (SS-) RNA. The proportion of SS-RNA was considerably lower in N. plumbaginifolia protoplasts. In infected plants, SS-RNA was hardly detectable, suggesting either that SS-RNA is unstable in infected plants or that read-through of the promoter-proximal poly(A) site is very efficient. SS-RNA is readily detectable in transgenic rice plants (A. Klöti, C. Henrich, S. Bieri, X. He, G. Chen, P. K. Burkhardt, J. Wünn, P. Lucca, T. Hohn, I. Potrylus, and J. Fütterer, 1999. Plant Mol. Biol. 40:249–266), thus the absence of SS-RNA in infected plants can be attributed to poly(A) site bypass in the viral context to ensure production of the full-length pregenomic viral RNA. RTBV poly(A) site suppression thus depends both on context and the expression system; our results suggest that the circular viral minichromosome directs assembly of a transcription-processing complex with specific properties to effect read-through of the promoter-proximal poly(A) signal. PMID:11287568

  1. The differential regulation of human ACT1 isoforms by Hsp90 in IL-17 signaling1

    PubMed Central

    Wu, Ling; Wang, Chenhui; Boisson, Bertrand; Misra, Saurav; Rayman, Patricia; Finke, James H.; Puel, Anne; Casanova, Jean-Laurent; Li, Xiaoxia

    2014-01-01

    IL-17 is a pro-inflammatory cytokine implicated in the pathogenesis of autoimmune diseases including psoriasis. ACT1 is an essential adaptor molecule in the IL-17 signaling pathway. A missense single nucleotide polymorphism (rs33980500; SNP-D10N) that resulted in the substitution of an asparagine for an aspartic acid at position 10 of ACT1 (ACT1-D10N) is associated with psoriasis susceptibility. Due to alternative splicing in humans, SNP-D10N encodes two mutated ACT1 proteins, ACT1-D10N and ACT1-D19N. Though both ACT1 isoforms are Hsp90 ‘client’ proteins, the nine additional amino acids in ACT1-D19N provide an additional Hsp90 binding site that is absent in ACT1-D10N. Therefore, while ACT1-D10N is a dead protein that is unable to transduce IL-17 signals for gene expression, ACT1-D19N is fully responsive to IL-17. Intriguingly, the two ACT1 isoforms are differentially expressed in ACT1D10N/D10N fibroblasts and T cells. Fibroblasts express both isoforms equally, enabling ACT1-D19N to compensate for the loss of ACT1-D10N function. ACT1D10N/D10N T cells, however, express predominantly ACT1-D10N. Lacking this compensatory mechanism, ACT1D10N/D10N T cells behave like ACT1-deficient T cells, exhibiting a dysregulated and hyperactive Th17 phenotype with overproduction of IL-22 and IL-17. The hyperactive Th17 response combined with fully responsive fibroblasts likely synergized to contribute to psoriasis susceptibility in SNP-D10N patients. PMID:25024377

  2. The differential regulation of human ACT1 isoforms by Hsp90 in IL-17 signaling.

    PubMed

    Wu, Ling; Wang, Chenhui; Boisson, Bertrand; Misra, Saurav; Rayman, Patricia; Finke, James H; Puel, Anne; Casanova, Jean-Laurent; Li, Xiaoxia

    2014-08-15

    IL-17 is a proinflammatory cytokine implicated in the pathogenesis of autoimmune diseases including psoriasis. ACT1 is an essential adaptor molecule in the IL-17 signaling pathway. A missense single nucleotide polymorphism (rs33980500; SNP-D10N) that resulted in the substitution of an asparagine for an aspartic acid at position 10 of ACT1 (ACT1-D10N) is associated with psoriasis susceptibility. Due to alternative splicing in humans, SNP-D10N encodes two mutated ACT1 proteins, ACT1-D10N and ACT1-D19N. Although both ACT1 isoforms are Hsp90 client proteins, the nine additional amino acids in ACT1-D19N provide an additional Hsp90 binding site that is absent in ACT1-D10N. Therefore, whereas ACT1-D10N is a dead protein that is unable to transduce IL-17 signals for gene expression, ACT1-D19N is fully responsive to IL-17. Intriguingly, the two ACT1 isoforms are differentially expressed in ACT1(D10N/D10N) fibroblasts and T cells. Fibroblasts express both isoforms equally, enabling ACT1-D19N to compensate for the loss of ACT1-D10N function. ACT1(D10N/D10N) T cells, however, express predominantly ACT1-D10N. Lacking this compensatory mechanism, ACT1(D10N/D10N) T cells behave like ACT1-deficient T cells, exhibiting a dysregulated and hyperactive Th17 phenotype with overproduction of IL-22 and IL-17. The hyperactive Th17 response combined with fully responsive fibroblasts likely synergized to contribute to psoriasis susceptibility in SNP-D10N patients. PMID:25024377

  3. Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity

    PubMed Central

    Panayiotou, Richard; Miralles, Francesc; Pawlowski, Rafal; Diring, Jessica; Flynn, Helen R; Skehel, Mark; Treisman, Richard

    2016-01-01

    The myocardin-related transcription factors (MRTF-A and MRTF-B) regulate cytoskeletal genes through their partner transcription factor SRF. The MRTFs bind G-actin, and signal-regulated changes in cellular G-actin concentration control their nuclear accumulation. The MRTFs also undergo Rho- and ERK-dependent phosphorylation, but the function of MRTF phosphorylation, and the elements and signals involved in MRTF-A nuclear export are largely unexplored. We show that Rho-dependent MRTF-A phosphorylation reflects relief from an inhibitory function of nuclear actin. We map multiple sites of serum-induced phosphorylation, most of which are S/T-P motifs and show that S/T-P phosphorylation is required for transcriptional activation. ERK-mediated S98 phosphorylation inhibits assembly of G-actin complexes on the MRTF-A regulatory RPEL domain, promoting nuclear import. In contrast, S33 phosphorylation potentiates the activity of an autonomous Crm1-dependent N-terminal NES, which cooperates with five other NES elements to exclude MRTF-A from the nucleus. Phosphorylation thus plays positive and negative roles in the regulation of MRTF-A. DOI: http://dx.doi.org/10.7554/eLife.15460.001 PMID:27304076

  4. Two-Step Regulation of a Meristematic Cell Population Acting in Shoot Branching in Arabidopsis

    PubMed Central

    Tian, Caihuan; Wang, Jin; Xu, Tengfei; Xu, Yan; Ohno, Carolyn; Sablowski, Robert; Heisler, Marcus G.; Theres, Klaus; Wang, Ying

    2016-01-01

    Shoot branching requires the establishment of new meristems harboring stem cells; this phenomenon raises questions about the precise regulation of meristematic fate. In seed plants, these new meristems initiate in leaf axils to enable lateral shoot branching. Using live-cell imaging of leaf axil cells, we show that the initiation of axillary meristems requires a meristematic cell population continuously expressing the meristem marker SHOOT MERISTEMLESS (STM). The maintenance of STM expression depends on the leaf axil auxin minimum. Ectopic expression of STM is insufficient to activate axillary buds formation from plants that have lost leaf axil STM expressing cells. This suggests that some cells undergo irreversible commitment to a developmental fate. In more mature leaves, REVOLUTA (REV) directly up-regulates STM expression in leaf axil meristematic cells, but not in differentiated cells, to establish axillary meristems. Cell type-specific binding of REV to the STM region correlates with epigenetic modifications. Our data favor a threshold model for axillary meristem initiation, in which low levels of STM maintain meristematic competence and high levels of STM lead to meristem initiation. PMID:27398935

  5. PP2A and GSK-3beta act antagonistically to regulate active zone development.

    PubMed

    Viquez, Natasha M; Füger, Petra; Valakh, Vera; Daniels, Richard W; Rasse, Tobias M; DiAntonio, Aaron

    2009-09-16

    The synapse is composed of an active zone apposed to a postsynaptic cluster of neurotransmitter receptors. Each Drosophila neuromuscular junction comprises hundreds of such individual release sites apposed to clusters of glutamate receptors. Here, we show that protein phosphatase 2A (PP2A) is required for the development of structurally normal active zones opposite glutamate receptors. When PP2A is inhibited presynaptically, many glutamate receptor clusters are unapposed to Bruchpilot (Brp), an active zone protein required for normal transmitter release. These unapposed receptors are not due to presynaptic retraction of synaptic boutons, since other presynaptic components are still apposed to the entire postsynaptic specialization. Instead, these data suggest that Brp localization is regulated at the level of individual release sites. Live imaging of glutamate receptors demonstrates that this disruption to active zone development is accompanied by abnormal postsynaptic development, with decreased formation of glutamate receptor clusters. Remarkably, inhibition of the serine-threonine kinase GSK-3beta completely suppresses the active zone defect, as well as other synaptic morphology phenotypes associated with inhibition of PP2A. These data suggest that PP2A and GSK-3beta function antagonistically to control active zone development, providing a potential mechanism for regulating synaptic efficacy at a single release site.

  6. 75 FR 60263 - Federal Acquisition Regulation; Offering a Construction Requirement-8(a) Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-29

    ... Federal Acquisition Regulation; Offering a Construction Requirement--8(a) Program AGENCIES: Department of... Regulations Council (Councils) are issuing a final rule amending the Federal Acquisition Regulation (FAR) to revise FAR subpart 19.8, Contracting with the Small Business Administration (The 8(a) Program),...

  7. 13 CFR 120.1511 - Certification and other reporting and notification requirements for Other Regulated SBLCs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) Certification. An SBLC seeking Other Regulated SBLC status must certify to SBA in writing that its lending... or state banking regulator that regulates the lending activities of the SBLC; (2) A statement that... may appeal this decision to the AA/CA. (g) Failure to satisfy requirements. In the event that an...

  8. 77 FR 29983 - Federal Acquisition Regulation; Information Collection; Novation/Change of Name Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ... Regulation; Information Collection; Novation/ Change of Name Requirements AGENCY: Department of Defense (DOD... collection requirement concerning Novation/Change of Name Requirements. Public comments are particularly... comments identified by Information Collection 9000- 0076, Novation/Change of Name Requirements, by any...

  9. 76 FR 35218 - Federal Acquisition Regulation; Information Collection; Cost or Pricing Data Requirements and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-16

    ... Regulation; Information Collection; Cost or Pricing Data Requirements and Information Other Than Cost or... requirement concerning cost or pricing data requirements and information other than cost or pricing data... Information Collection 9000- 0013, Cost or Pricing Data Requirements and Information Other Than Cost...

  10. Prediction of Regulation Reserve Requirements in California ISO Control Area based on BAAL Standard

    SciTech Connect

    Etingov, Pavel V.; Makarov, Yuri V.; Samaan, Nader A.; Ma, Jian; Loutan, Clyde

    2013-07-21

    This paper presents new methodologies developed at Pacific Northwest National Laboratory (PNNL) to estimate regulation capacity requirements in the California ISO control area. Two approaches have been developed: (1) an approach based on statistical analysis of actual historical area control error (ACE) and regulation data, and (2) an approach based on balancing authority ACE limit control performance standard. The approaches predict regulation reserve requirements on a day-ahead basis including upward and downward requirements, for each operating hour of a day. California ISO data has been used to test the performance of the proposed algorithms. Results show that software tool allows saving up to 30% on the regulation procurements cost .

  11. 76 FR 71558 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Requests...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-18

    ... Defense Acquisition Regulations System Information Collection Requirement; Defense Federal Acquisition... Acquisition Regulations System, Department of Defense (DoD). ACTION: Notice and request for comments. SUMMARY...), DoD announces the proposed extension of a public information collection requirement and seeks...

  12. 75 FR 964 - Acquisition Regulation: Subchapter E-General Contracting Requirements, Subchapter F-Special...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-07

    ... Regulation: Subchapter E--General Contracting Requirements, Subchapter F--Special Categories of Contracting... Acquisition Regulation (DEAR) Subchapters E-- General Contracting Requirements, F--Special Categories of...: Subchapters E, F, and G and RIN 1991-AB88, by any of the following methods: Federal eRulemaking Portal:...

  13. Positive Selection within a Diatom Species Acts on Putative Protein Interactions and Transcriptional Regulation

    PubMed Central

    Koester, Julie A.; Swanson, Willie J.; Armbrust, E. Virginia

    2013-01-01

    Diatoms are the most species-rich group of microalgae, and their contribution to marine primary production is important on a global scale. Diatoms can form dense blooms through rapid asexual reproduction; mutations acquired and propagated during blooms likely provide the genetic, and thus phenotypic, variability upon which natural selection may act. Positive selection was tested using genome and transcriptome-wide pair-wise comparisons of homologs in three genera of diatoms (Pseudo-nitzschia, Ditylum, and Thalassiosira) that represent decreasing phylogenetic distances. The signal of positive selection was greatest between two strains of Thalassiosira pseudonana. Further testing among seven strains of T. pseudonana yielded 809 candidate genes of positive selection, which are 7% of the protein-coding genes. Orphan genes and genes encoding protein-binding domains and transcriptional regulators were enriched within the set of positively selected genes relative to the genome as a whole. Positively selected genes were linked to the potential selective pressures of nutrient limitation and sea surface temperature based on analysis of gene expression profiles and identification of positively selected genes in subsets of strains from locations with similar environmental conditions. The identification of positively selected genes presents an opportunity to test new hypotheses in natural populations and the laboratory that integrate selected genotypes in T. pseudonana with their associated phenotypes and selective forces. PMID:23097498

  14. Positive selection within a diatom species acts on putative protein interactions and transcriptional regulation.

    PubMed

    Koester, Julie A; Swanson, Willie J; Armbrust, E Virginia

    2013-02-01

    Diatoms are the most species-rich group of microalgae, and their contribution to marine primary production is important on a global scale. Diatoms can form dense blooms through rapid asexual reproduction; mutations acquired and propagated during blooms likely provide the genetic, and thus phenotypic, variability upon which natural selection may act. Positive selection was tested using genome and transcriptome-wide pair-wise comparisons of homologs in three genera of diatoms (Pseudo-nitzschia, Ditylum, and Thalassiosira) that represent decreasing phylogenetic distances. The signal of positive selection was greatest between two strains of Thalassiosira pseudonana. Further testing among seven strains of T. pseudonana yielded 809 candidate genes of positive selection, which are 7% of the protein-coding genes. Orphan genes and genes encoding protein-binding domains and transcriptional regulators were enriched within the set of positively selected genes relative to the genome as a whole. Positively selected genes were linked to the potential selective pressures of nutrient limitation and sea surface temperature based on analysis of gene expression profiles and identification of positively selected genes in subsets of strains from locations with similar environmental conditions. The identification of positively selected genes presents an opportunity to test new hypotheses in natural populations and the laboratory that integrate selected genotypes in T. pseudonana with their associated phenotypes and selective forces. PMID:23097498

  15. Impact of Clean Air Act Regulations on Nitrogen Fate and Transport in the Neuse River Basin

    NASA Astrophysics Data System (ADS)

    Gabriel, M. C.; Knightes, C. D.; Dennis, R. L.; Cooter, E. J.

    2012-12-01

    This study investigated impacts of Clean Air Act Amendment (CAAA) NOx emissions regulations on the fate and transport of nitrogen for two watersheds in the Neuse River Basin, North Carolina, USA from 1990 to 2020. The Soil and Water Assessment Tool (SWAT) and the Community Multi-scale Air Quality (CMAQ) modeling system were used. CMAQ simulated atmospheric chemical transport and nitrogen deposition. This data was entered into SWAT which simulated watershed hydrology and water quality. Two cases were investigated: one that incorporates CAAA regulatory emissions controls in CMAQ simulation (with) and a second case that does not (without). SWAT model results forecasted a 70% decrease in inorganic nitrogen discharge from the Little River watershed and a 50% decrease for the Nahunta watershed by 2020 under the emission control (with) scenario. Denitrification and plant nitrogen uptake played important roles in nitrogen discharge from each watershed. The nitrogen discharge response time following a change in atmospheric nitrogen deposition was 4 years for the Nahunta watershed and 2 years for the Little River watershed. The longer response time for Nahunta is primarily due to a higher percentage of soybean land cover (22.5% [Nahunta]; 1.6% [Little River]). Agricultural land covers had varied nitrogen response times to changes in atmospheric deposition, particularly for soybean, hay and corn. The studied watersheds retained >80% of all nitrogen delivered by agriculture fertilization, biological fixation and atmospheric deposition.

  16. 16 CFR 500.3 - Prohibited acts, coverage, general labeling requirements, exemption procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... the Act, shall bear a label specifying the identity of the commodity; the name and place of business... initiative or pursuant to petition filed with the Secretary by any interested person or group...

  17. 16 CFR 500.3 - Prohibited acts, coverage, general labeling requirements, exemption procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... the Act, shall bear a label specifying the identity of the commodity; the name and place of business... initiative or pursuant to petition filed with the Secretary by any interested person or group...

  18. 16 CFR 500.3 - Prohibited acts, coverage, general labeling requirements, exemption procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... the Act, shall bear a label specifying the identity of the commodity; the name and place of business... initiative or pursuant to petition filed with the Secretary by any interested person or group...

  19. 21 CFR 1271.10 - Are my HCT/P's regulated solely under section 361 of the PHS Act and the regulations in this part...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) REGULATIONS UNDER CERTAIN OTHER ACTS ADMINISTERED BY THE FOOD AND DRUG ADMINISTRATION HUMAN CELLS, TISSUES... objective intent; (3) The manufacture of the HCT/P does not involve the combination of the cells or tissues... not have a systemic effect and is not dependent upon the metabolic activity of living cells for...

  20. 21 CFR 1271.10 - Are my HCT/P's regulated solely under section 361 of the PHS Act and the regulations in this part...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) REGULATIONS UNDER CERTAIN OTHER ACTS ADMINISTERED BY THE FOOD AND DRUG ADMINISTRATION HUMAN CELLS, TISSUES... objective intent; (3) The manufacture of the HCT/P does not involve the combination of the cells or tissues... not have a systemic effect and is not dependent upon the metabolic activity of living cells for...

  1. 21 CFR 21.70 - Disclosure and intra-agency use of records in Privacy Act Record Systems; no accounting required.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Privacy Act Record Systems; no accounting required. 21.70 Section 21.70 Food and Drugs FOOD AND DRUG... Privacy Act Record Systems to Persons Other Than the Subject Individual § 21.70 Disclosure and intra-agency use of records in Privacy Act Record Systems; no accounting required. (a) A record about...

  2. 48 CFR 52.225-12 - Notice of Buy American Act Requirement-Construction Materials Under Trade Agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Requirement-Construction Materials Under Trade Agreements. 52.225-12 Section 52.225-12 Federal Acquisition...—Construction Materials Under Trade Agreements. As prescribed in 25.1102(d)(1), insert the following provision: Notice of Buy American Act Requirement—Construction Materials Under Trade Agreements (FEB 2009)...

  3. 48 CFR 52.225-12 - Notice of Buy American Act Requirement-Construction Materials Under Trade Agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Requirement-Construction Materials Under Trade Agreements. 52.225-12 Section 52.225-12 Federal Acquisition...—Construction Materials Under Trade Agreements. As prescribed in 25.1102(d)(1), insert the following provision: Notice of Buy American Act Requirement—Construction Materials Under Trade Agreements (FEB 2009)...

  4. 48 CFR 52.225-12 - Notice of Buy American Act Requirement-Construction Materials Under Trade Agreements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Requirement-Construction Materials Under Trade Agreements. 52.225-12 Section 52.225-12 Federal Acquisition...—Construction Materials Under Trade Agreements. As prescribed in 25.1102(d)(1), insert the following provision: Notice of Buy American Act Requirement—Construction Materials Under Trade Agreements (FEB 2009)...

  5. 48 CFR 52.225-12 - Notice of Buy American Act Requirement-Construction Materials Under Trade Agreements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Requirement-Construction Materials Under Trade Agreements. 52.225-12 Section 52.225-12 Federal Acquisition...—Construction Materials Under Trade Agreements. As prescribed in 25.1102(d)(1), insert the following provision: Notice of Buy American Act Requirement—Construction Materials Under Trade Agreements (FEB 2009)...

  6. 2 CFR 176.190 - Award term-Wage rate requirements under Section 1606 of the Recovery Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Award term-Wage rate requirements under Section 1606 of the Recovery Act. 176.190 Section 176.190 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved AWARD TERMS...

  7. [Legal framework of data protection : current requirements in Germany and requirements in planned European Union regulations].

    PubMed

    Schütze, B

    2013-05-01

    The federal system in Germany necessitates that in addition to federal laws, country and church-specific legislations must also be considered during the evaluation of relevant legal stipulations concerning data protection. Furthermore, there are also special legal regulations for hospitals in almost every federal state which are governed by the principle of subsidiarity: special legal regulations are to be preferentially used, so that findings from one federal state are difficult to transfer to another federal state.Patient data may only be used and processed without legal regulations with informed consent of the patient. The use of patient data for purposes of quality assurance, research and further education of students and doctors is possible under the present laws according to a positive weighting of interests. Patient data can also be exchanged via online services for the purposes of patient care; however, informed consent of the patient for medical online services is almost always unavoidable.

  8. 15 CFR Supplement No. 1 to Part 730 - Information Collection Requirements Under the Paperwork Reduction Act: OMB Control Numbers

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Information Collection Requirements... requirements for the Bureau of Industry and Security by the Office of Management and Budget (OMB), pursuant...

  9. 15 CFR Supplement No. 1 to Part 730 - Information Collection Requirements Under the Paperwork Reduction Act: OMB Control Numbers

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Information Collection Requirements... requirements for the Bureau of Industry and Security by the Office of Management and Budget (OMB), pursuant...

  10. 15 CFR Supplement No. 1 to Part 730 - Information Collection Requirements Under the Paperwork Reduction Act: OMB Control Numbers

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Information Collection Requirements... requirements for the Bureau of Industry and Security by the Office of Management and Budget (OMB), pursuant...

  11. 78 FR 60381 - Amendments to the 2013 Mortgage Rules Under the Equal Credit Opportunity Act (Regulation B), Real...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-01

    ... February 15, 2013, at 78 FR 11280. FOR FURTHER INFORMATION CONTACT: Whitney Patross, Attorney; Richard... Under the Truth in Lending Act (Regulation Z), 78 FR 4726 (Jan. 22, 2013) (2013 Escrows Final Rule...), 78 FR 6856 (Jan. 31, 2013) (2013 HOEPA Final Rule), and Ability-to-Repay and Qualified...

  12. 9 CFR 331.3 - States designated under paragraph 301(c) of the Act; application of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false States designated under paragraph 301(c) of the Act; application of regulations. 331.3 Section 331.3 Animals and Animal Products FOOD... DESIGNATED STATES AND TERRITORIES; AND FOR DESIGNATION OF ESTABLISHMENTS WHICH ENDANGER PUBLIC HEALTH AND...

  13. 9 CFR 381.222 - States designated under paragraph 5(c) of the Act; application of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false States designated under paragraph 5(c) of the Act; application of regulations. 381.222 Section 381.222 Animals and Animal Products FOOD... Designating Establishments With Operations Which Would Clearly Endanger the Public Health; Disposition...

  14. 76 FR 28966 - Revisions to Oil Pipeline Regulations Pursuant to the Energy Policy Act of 1992; Notice of Annual...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Revisions to Oil Pipeline Regulations Pursuant to the Energy Policy Act of 1992; Notice of Annual Change in the Producer Price Index for Finished Goods The...

  15. 29 CFR 102.117 - Freedom of Information Act Regulations: Board materials and formal documents available for public...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., the cost of conducting computer searches for information and for providing information in electronic... 29 Labor 2 2010-07-01 2010-07-01 false Freedom of Information Act Regulations: Board materials and... for response; appeal from denial of request; fees for document search and duplication; files...

  16. 78 FR 63408 - Petition To Amend Animal Welfare Act Regulations To Prohibit Public Contact With Big Cats, Bears...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-24

    ... 5, 2013 (78 FR 47215) is reopened. We will consider all comments that we receive on or before.... SUPPLEMENTARY INFORMATION: On August 5, 2013, we published in the Federal Register (78 FR 47215-47217, Docket No... Animal Welfare Act Regulations To Prohibit Public Contact With Big Cats, Bears, and Nonhuman...

  17. 78 FR 23171 - Amendments to the 2013 Escrows Final Rule Under the Truth in Lending Act (Regulation Z)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-18

    ... loans made in ``rural'' or ``underserved'' areas. \\1\\ 78 FR 4726 (Jan. 22, 2013). \\2\\ The other rules...) (2013 ATR Final Rule), 78 FR 6407; High-Cost Mortgages and Homeownership Counseling Amendments to the... Settlement Procedures Act (Regulation X) (2013 HOEPA Final Rule), 78 FR 6855; Disclosure and...

  18. 9 CFR 381.222 - States designated under paragraph 5(c) of the Act; application of regulations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false States designated under paragraph 5(c) of the Act; application of regulations. 381.222 Section 381.222 Animals and Animal Products FOOD... Designating Establishments With Operations Which Would Clearly Endanger the Public Health; Disposition...

  19. Deeming Tobacco Products To Be Subject to the Federal Food, Drug, and Cosmetic Act, as Amended by the Family Smoking Prevention and Tobacco Control Act; Restrictions on the Sale and Distribution of Tobacco Products and Required Warning Statements for Tobacco Products. Final rule.

    PubMed

    2016-05-10

    The Food and Drug Administration (FDA) is issuing this final rule to deem products meeting the statutory definition of "tobacco product,'' except accessories of the newly deemed tobacco products, to be subject to the Federal Food, Drug, and Cosmetic Act (the FD&C Act), as amended by the Family Smoking Prevention and Tobacco Control Act (Tobacco Control Act). The Tobacco Control Act provides FDA authority to regulate cigarettes, cigarette tobacco, roll-your-own tobacco, smokeless tobacco, and any other tobacco products that the Agency by regulation deems to be subject to the law. With this final rule, FDA is extending the Agency's "tobacco product'' authorities in the FD&C Act to all other categories of products that meet the statutory definition of "tobacco product" in the FD&C Act, except accessories of such newly deemed tobacco products. This final rule also prohibits the sale of "covered tobacco products" to individuals under the age of 18 and requires the display of health warnings on cigarette tobacco, roll-your own tobacco, and covered tobacco product packages and in advertisements. FDA is taking this action to reduce the death and disease from tobacco products. In accordance with the Tobacco Control Act, we consider and intend the extension of our authorities over tobacco products and the various requirements and prohibitions established by this rule to be severable. PMID:27192730

  20. Deeming Tobacco Products To Be Subject to the Federal Food, Drug, and Cosmetic Act, as Amended by the Family Smoking Prevention and Tobacco Control Act; Restrictions on the Sale and Distribution of Tobacco Products and Required Warning Statements for Tobacco Products. Final rule.

    PubMed

    2016-05-10

    The Food and Drug Administration (FDA) is issuing this final rule to deem products meeting the statutory definition of "tobacco product,'' except accessories of the newly deemed tobacco products, to be subject to the Federal Food, Drug, and Cosmetic Act (the FD&C Act), as amended by the Family Smoking Prevention and Tobacco Control Act (Tobacco Control Act). The Tobacco Control Act provides FDA authority to regulate cigarettes, cigarette tobacco, roll-your-own tobacco, smokeless tobacco, and any other tobacco products that the Agency by regulation deems to be subject to the law. With this final rule, FDA is extending the Agency's "tobacco product'' authorities in the FD&C Act to all other categories of products that meet the statutory definition of "tobacco product" in the FD&C Act, except accessories of such newly deemed tobacco products. This final rule also prohibits the sale of "covered tobacco products" to individuals under the age of 18 and requires the display of health warnings on cigarette tobacco, roll-your own tobacco, and covered tobacco product packages and in advertisements. FDA is taking this action to reduce the death and disease from tobacco products. In accordance with the Tobacco Control Act, we consider and intend the extension of our authorities over tobacco products and the various requirements and prohibitions established by this rule to be severable.

  1. Temporal requirements of the fragile X mental retardation protein in the regulation of synaptic structure.

    PubMed

    Gatto, Cheryl L; Broadie, Kendal

    2008-08-01

    Fragile X syndrome (FraX), caused by the loss-of-function of one gene (FMR1), is the most common inherited form of both mental retardation and autism spectrum disorders. The FMR1 product (FMRP) is an mRNA-binding translation regulator that mediates activity-dependent control of synaptic structure and function. To develop any FraX intervention strategy, it is essential to define when and where FMRP loss causes the manifestation of synaptic defects, and whether the reintroduction of FMRP can restore normal synapse properties. In the Drosophila FraX model, dFMRP loss causes neuromuscular junction (NMJ) synapse over-elaboration (overgrowth, overbranching, excess synaptic boutons), accumulation of development-arrested satellite boutons, and altered neurotransmission. We used the Gene-Switch method to conditionally drive dFMRP expression to define the spatiotemporal requirements in synaptic mechanisms. Constitutive induction of targeted neuronal dFMRP at wild-type levels rescues all synaptic architectural defects in Drosophila Fmr1 (dfmr1)-null mutants, demonstrating a presynaptic requirement for synapse structuring. By contrast, presynaptic dFMRP expression does not ameliorate functional neurotransmission defects, indicating a postsynaptic dFMRP requirement. Strikingly, targeted early induction of dFMRP effects nearly complete rescue of synaptic structure defects, showing a primarily early-development role. In addition, acute dFMRP expression at maturity partially alleviates dfmr1-null defects, although rescue is not as complete as either early or constitutive dFMRP expression, showing a modest capacity for late-stage structural plasticity. We conclude that dFMRP predominantly acts early in synaptogenesis to modulate architecture, but that late dFMRP introduction at maturity can weakly compensate for early absence of dFMRP function. PMID:18579676

  2. Application of TALEs, CRISPR/Cas and sRNAs as trans-acting regulators in prokaryotes.

    PubMed

    Copeland, Matthew F; Politz, Mark C; Pfleger, Brian F

    2014-10-01

    The last several years have witnessed an explosion in the understanding and use of novel, versatile trans-acting elements. TALEs, CRISPR/Cas, and sRNAs can be easily fashioned to bind any specific sequence of DNA (TALEs, CRISPR/Cas) or RNA (sRNAs) because of the simple rules governing their interactions with nucleic acids. This unique property enables these tools to repress the expression of genes at the transcriptional or post-transcriptional levels, respectively, without prior manipulation of cis-acting and/or chromosomal target DNA sequences. These tools are now being harnessed by synthetic biologists, particularly those in the eukaryotic community, for genome-wide regulation, editing, or epigenetic studies. Here we discuss the exciting opportunities for using TALEs, CRISPR/Cas, and sRNAs as synthetic trans-acting regulators in prokaryotes.

  3. 17 CFR 230.508 - Insignificant deviations from a term, condition or requirement of Regulation D.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., Dec. 30, 1958, unless otherwise noted. Cross Reference: For regulations of Small Business Administration under the Small Business Investment Act of 1958, see 13 CFR, Chapter I. ... Small Business Investment Companies Authority: Sections 230.601 to 230.610a issued under sec. 19,...

  4. 17 CFR 230.508 - Insignificant deviations from a term, condition or requirement of Regulation D.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., Dec. 30, 1958, unless otherwise noted. Cross Reference: For regulations of Small Business Administration under the Small Business Investment Act of 1958, see 13 CFR, Chapter I. ... Small Business Investment Companies Authority: Sections 230.601 to 230.610a issued under sec. 19,...

  5. 17 CFR 230.508 - Insignificant deviations from a term, condition or requirement of Regulation D.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., Dec. 30, 1958, unless otherwise noted. Cross Reference: For regulations of Small Business Administration under the Small Business Investment Act of 1958, see 13 CFR, Chapter I. ... Small Business Investment Companies Authority: Sections 230.601 to 230.610a issued under sec. 19,...

  6. Bacillus subtilis glutamine synthetase regulates its own synthesis by acting as a chaperone to stabilize GlnR-DNA complexes.

    PubMed

    Fisher, Susan H; Wray, Lewis V

    2008-01-22

    The Bacillus subtilis GlnR repressor controls gene expression in response to nitrogen availability. Because all GlnR-regulated genes are expressed constitutively in mutants lacking glutamine synthetase (GS), GS is required for repression by GlnR. Feedback-inhibited GS (FBI-GS) was shown to activate GlnR DNA binding with an in vitro electophoretic mobility shift assay (EMSA). The activation of GlnR DNA binding by GS in these experiments depended on the feedback inhibitor glutamine and did not occur with mutant GS proteins defective in regulating GlnR activity in vivo. Although stable GS-GlnR-DNA ternary complexes were not observed in the EMSA experiments, cross-linking experiments showed that a protein-protein interaction occurs between GlnR and FBI-GS. This interaction was reduced in the absence of the feedback inhibitor glutamine and with mutant GS proteins. Because FBI-GS significantly reduced the dissociation rate of the GlnR-DNA complexes, the stability of these complexes is enhanced by FBI-GS. These results argue that FBI-GS acts as a chaperone that activates GlnR DNA binding through a transient protein-protein interaction that stabilizes GlnR-DNA complexes. GS was shown to control the activity of the B. subtilis nitrogen transcription factor TnrA by forming a stable complex between FBI-GS and TnrA that inhibits TnrA DNA binding. Thus, B. subtilis GS is an enzyme with dual catalytic and regulatory functions that uses distinct mechanisms to control the activity of two different transcription factors.

  7. Transferrin synthesis by small cell lung cancer cells acts as an autocrine regulator of cellular proliferation.

    PubMed Central

    Vostrejs, M; Moran, P L; Seligman, P A

    1988-01-01

    Since transferrin is required for cellular proliferation, we investigated transferrin synthesis by a small cell lung cancer line (NCI-H510) that survives in serum-free media without added transferrin. Immunoassays for human transferrin demonstrated that these cells contained immunoreactive human transferrin. Immunofluorescence studies showed that the protein is expressed on the surface of cells, presumably bound to transferrin receptor. Media conditioned by NCI-H510 cells support proliferation of human leukemic cells that would not survive in media lacking transferrin. [35S]Methionine incorporation documented transferrin synthesis by NCI-H510 cells as well as three other small cell lines. Transferrin synthesis by NCI-H510 cells increased more than 10-fold when cells entered active phases of the cell cycle, and this increase was seen before large increases in transferrin-receptor expression. Further experiments examining the effects of agents that affect iron metabolism show that the addition of transferrin-iron or hemin to the media is associated with a more rapid initial rate of proliferation and lower rates of transferrin synthesis than control cells. Gallium salts, which inhibit iron uptake, inhibited proliferation of these cells. If the cells recovered from this effect, transferrin synthesis remained greatly increased compared to control. We conclude that transferrin synthesis by these malignant cells is ultimately related to an iron requirement for cellular proliferation. It appears that this synthesized transferrin acts as part of an important autocrine mechanism permitting proliferation of these cells, and perhaps permitting tumor cell growth in vivo in areas not well vascularized. Images PMID:2839550

  8. 76 FR 10527 - Regulatory Flexibility Act: Section 610 Review of National Organic Program Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-25

    ... regulations implementing the National Organic Program (NOP) were published December 21, 2000 (65 FR 80548... FR 14827), its schedule to review certain regulations, including the NOP regulations, under criteria... Organic Program Regulations AGENCY: Agricultural Marketing Service, USDA. ACTION: Review and request...

  9. Child Labor Requirements in Agriculture under the Fair Labor Standards Act. Child Labor Bulletin No. 102.

    ERIC Educational Resources Information Center

    Employment Standards Administration (DOL), Washington, DC. Wage and Hour Div.

    This booklet is a guide to the provisions of the Fair Labor Standards Act (also known as the Wage-Hour Law) which apply to minors employed in agriculture. The content is as follows: coverage of the child labor provisions regarding agricultural employment, minimum age standards for employment in agriculture, school hours and employment in…

  10. 77 FR 28790 - Medical Loss Ratio Requirements Under the Patient Protection and Affordable Care Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-16

    ... Patient Protection and Affordable Care Act (75 FR 34538) published on June 17, 2010, it was estimated that... on May 5, 2010 (75 FR 24470) relating to the Federal health care reform insurance Web Portal... Federal Register on April 14, 2010 (75 FR 19297). On December 1, 2010, the Department of Health and...

  11. 17 CFR 23.440 - Requirements for swap dealers acting as advisors to Special Entities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... the swap dealer recommends a swap or trading strategy involving a swap that is tailored to the particular needs or characteristics of the Special Entity. (b) Safe harbors. A swap dealer will not “act as... evaluated by a fiduciary before the transaction occurs; or (B) That any recommendation the Special...

  12. 78 FR 6056 - Designation of Payor as Agent To Perform Acts Required of an Employer

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ... Federal Unemployment Tax Act (FUTA) taxes under section 3301. Instead of FICA taxes, railroad employers... employer pays that are subject to FUTA tax are reported annually on Form 940, Employer's Annual Federal Unemployment Tax (FUTA) Return. Employers that pay compensation subject to the RRTA file Form CT-1,...

  13. 76 FR 76573 - Medical Loss Ratio Requirements Under the Patient Protection and Affordable Care Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-07

    ... group markets. DATES: Effective date. This rule is effective on January 3, 2012. Comment date. We will... individual markets. A request for information relating to the medical loss ratio (MLR) provisions of PHS Act section 2718 was published in the Federal Register on April 14, 2010 (75 FR 19297). On December 1,...

  14. Implementation of the Clean Air Act, Title III, Section 112(r) Prevention of Accidental Release Rule requirements at U.S. DOE Oak Ridge Reservation facilities

    SciTech Connect

    Humphreys, M.P.; Fellers, H.L.

    1997-12-31

    Title III, Section 112(r) of the Clean Air Act (CAA) Amendments of 1990 requires the Environmental Protection Agency (EPA) to promulgate regulations to prevent accidental releases of regulated substances and to reduce the severity of those releases that do occur. The final EPA rule for Risk Management Programs under Section 112(r)(7) of the CAA, promulgated June 20, 1996, applies to all stationary sources with processes that contain more than a threshold quantity of any of 139 regulated substances listed under 40 CFR 68.130. All affected sources will be required to prepare a risk management plan which must be submitted to EPA and be made available to state and local governments and to the public. This paper will provide details of initiatives underway at US Department of Energy (DOE) Oak Ridge Reservation (ORR) Facilities for implementation of the Prevention of Accidental Release Rule. The ORR encompasses three DOE Facilities: the Y-12 Plant, Oak Ridge National Laboratory (ORNL), and the K-25 Site. The Y-12 Plant manufactures component parts for the national nuclear weapons program; the ORNL is responsible for research and development activities including nuclear engineering, engineering technologies, and the environmental sciences; and the K-25 Site conducts a variety of research and development activities and is the home of a mixed waste incinerator. ORR activities underway and soon to be undertaken toward implementation of the Prevention of Accidental Release Rule include: compilation of inventories of regulated substances at all processes at each of the three ORR Facilities for determination of affected processes and facilities; plans for inventory reduction to levels below threshold quantities, where necessary and feasible; determination of the overlap of processes subject to the OSHA PSM Standard and determination of parallel requirements; preparation of Risk Management Plans and Programs for affected processes and facilities including detailed requirements

  15. 16 CFR 312.3 - Regulation of unfair or deceptive acts or practices in connection with the collection, use, and...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... children on the Internet. 312.3 Section 312.3 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS... information from and about children on the Internet. General requirements. It shall be unlawful for...

  16. 16 CFR 312.3 - Regulation of unfair or deceptive acts or practices in connection with the collection, use, and...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... children on the Internet. 312.3 Section 312.3 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS... information from and about children on the Internet. General requirements. It shall be unlawful for...

  17. 16 CFR 312.3 - Regulation of unfair or deceptive acts or practices in connection with the collection, use, and...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... children on the Internet. 312.3 Section 312.3 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS... information from and about children on the Internet. General requirements. It shall be unlawful for...

  18. 16 CFR 312.3 - Regulation of unfair or deceptive acts or practices in connection with the collection, use, and...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... children on the Internet. 312.3 Section 312.3 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS... information from and about children on the Internet. General requirements. It shall be unlawful for...

  19. 16 CFR 312.3 - Regulation of unfair or deceptive acts or practices in connection with the collection, use, and...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... children on the Internet. 312.3 Section 312.3 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS... information from and about children on the Internet. General requirements. It shall be unlawful for...

  20. Photogrammetry status in the act geodetic and cartographic law and connected regulations. (Polish Title: Status fotogrametrii w ustawie prawo geodezyjne i kartograficzne i przepisach powiazanych)

    NASA Astrophysics Data System (ADS)

    Pyka, K.; Myszka, P.

    2015-12-01

    The topic of the article is the analysis of regulations referring to photogrammetry, which have been in effect since the latest amendments in the Act Geodetic and Cartographic Law were introduced. Among many new rules, the four most important for regulations for photogrammetry were selected for the analysis. The largest part of analyses deals with so-called technical standards. This regulation introduces the term: geodetic photogrammetric measurement and places identical accuracy requirements as for field measurement. However, photogrammetric measurement, in this law is treated less thoroughly than other techniques. Often in this interpretation of the regulations there are different opinions between the ones who order the measurements and those who carry them out. The article shows which regulations are not satisfactorily clear and can be interpreted in different ways. Moreover, the article refers to unsatisfactory consistency between the analysed enactments. Finally, it was stated that the regulations, despite the indicated drawbacks, allow the application of photogrammetry in surveying and there is a prospect of granting photogrammetry the rank of the operation method, especially in large projects, e.g. the update of cadastral maps and land survey maps.

  1. 75 FR 12377 - Native American Graves Protection and Repatriation Act Regulations-Disposition of Culturally...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-15

    ... first rules to implement the Act on December 4, 1995 (43 CFR part 10, 60 FR 62158). --We published rules for assessing civil penalties under the Act on April 3, 2003 (43 CFR 10.12, 68 FR 16354). --We....13, 72 FR 13189). --We are publishing this rule today. --We are developing additional rules to...

  2. 75 FR 46859 - Lacey Act Implementation Plan; Definitions for Exempt and Regulated Articles

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-04

    ... addition, Section 3 of the Lacey Act, as amended, makes it unlawful, beginning December 15, 2008, to import... is being phased in, as described in two notices we published in the Federal Register (74 FR 5911-5913 and 74 FR 45415- 45418, Docket No. APHIS-2008-0119). Under the Act, ``Plant'' means: ``Any wild...

  3. A long noncoding RNA critically regulates Bcr-Abl-mediated cellular transformation by acting as a competitive endogenous RNA.

    PubMed

    Guo, G; Kang, Q; Zhu, X; Chen, Q; Wang, X; Chen, Y; Ouyang, J; Zhang, L; Tan, H; Chen, R; Huang, S; Chen, J-L

    2015-04-01

    Aberrant expression of long noncoding RNAs (lncRNAs) is associated with various human cancers. However, the role of lncRNAs in Bcr-Abl-mediated chronic myeloid leukemia (CML) is unknown. In this study, we performed a comprehensive analysis of lncRNAs in human CML cells using an lncRNA cDNA microarray and identified an lncRNA termed lncRNA-BGL3 that acted as a key regulator of Bcr-Abl-mediated cellular transformation. Notably, we observed that lncRNA-BGL3 was highly induced in response to disruption of Bcr-Abl expression or by inhibiting Bcr-Abl kinase activity in K562 cells and leukemic cells derived from CML patients. Ectopic expression of lncRNA-BGL3 sensitized leukemic cells to undergo apoptosis and inhibited Bcr-Abl-induced tumorigenesis. Furthermore, transgenic (TG) mice expressing lncRNA-BGL3 were generated. We found that TG expression of lncRNA-BGL3 alone in mice was sufficient to impair primary bone marrow transformation by Bcr-Abl. Interestingly, we identified that lncRNA-BGL3 was a target of miR-17, miR-93, miR-20a, miR-20b, miR-106a and miR-106b, microRNAs that repress mRNA of phosphatase and tensin homolog (PTEN). Further experiments demonstrated that lncRNA-BGL3 functioned as a competitive endogenous RNA for binding these microRNAs to cross-regulate PTEN expression. Additionally, our experiments have begun to address the mechanism of how lncRNA-BGL3 is regulated in the leukemic cells and showed that Bcr-Abl repressed lncRNA-BGL3 expression through c-Myc-dependent DNA methylation. Taken together, these results reveal that Bcr-Abl-mediated cellular transformation critically requires silence of tumor-suppressor lncRNA-BGL3 and suggest a potential strategy for the treatment of Bcr-Abl-positive leukemia.

  4. The French Space Operation Act: Scope and Main Features. Introduction to the Technical Regulation Considerations about the Implementation in the Launcher Field

    NASA Astrophysics Data System (ADS)

    Cahuzac, Francois

    2010-09-01

    This publication provides a presentation of the new French Space Operation Act(hereafter FSOA). The main objectives of FSOA are to institute a clarified legal regime for launch operations. The technical regulation associated to the act is set forth, in particular for the safety of persons and property, the protection of public health and the environment. First, we give an overview of the institutional and legal framework implemented in accordance with the act. The general purpose of this French Space Operation Act(hereafter FSOA) is to set up a coherent national regime of authorization and control of Space operations under the French jurisdiction or for which the French Government bears international liability either under UN Treaties principles(namely the 1967 Outer Space Treaty, the 1972 Liability Convention and the 1976 Registration Convention) or in accordance with its European commitments with the ESA organization and its Members States. For a given space operation, the operator must show that systems and procedures that he intends to implement are compliant with the technical regulation. The regime of authorization leads to a request of authorization for each launch operation. Thus, licences concerning operator management organization or a given space system can be obtained. These licences help to simplify the authorization file required for a given space operation. The technical regulation is presented in another article, and will be issued in 2010 by the French Minister in charge of space activities. A brief description of the organization associated to the implementation of the authorization regime in the launcher field is presented.

  5. 27 CFR 70.411 - Imposition of taxes, qualification requirements, and regulations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... operation of distilled spirits plants. Part 19 of title 27 CFR contains the regulations relating to the...) Miscellaneous liquor transactions. Part 29 of 27 CFR contains miscellaneous regulations relative to the... requirements therefor. (3) (4) Gauging of distilled spirits. Part 30 of title 27 CFR contains the...

  6. 27 CFR 70.411 - Imposition of taxes, qualification requirements, and regulations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... operation of distilled spirits plants. Part 19 of title 27 CFR contains the regulations relating to the...) Miscellaneous liquor transactions. Part 29 of 27 CFR contains miscellaneous regulations relative to the... requirements therefor. (3) (4) Gauging of distilled spirits. Part 30 of title 27 CFR contains the...

  7. 27 CFR 70.411 - Imposition of taxes, qualification requirements, and regulations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... operation of distilled spirits plants. Part 19 of title 27 CFR contains the regulations relating to the...) Miscellaneous liquor transactions. Part 29 of 27 CFR contains miscellaneous regulations relative to the... requirements therefor. (3) (4) Gauging of distilled spirits. Part 30 of title 27 CFR contains the...

  8. 27 CFR 70.411 - Imposition of taxes, qualification requirements, and regulations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... operation of distilled spirits plants. Part 19 of title 27 CFR contains the regulations relating to the...) Miscellaneous liquor transactions. Part 29 of 27 CFR contains miscellaneous regulations relative to the... requirements therefor. (3) (4) Gauging of distilled spirits. Part 30 of title 27 CFR contains the...

  9. 26 CFR 55.6001-1 - Notice or regulations requiring records, statements, and special returns.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... INVESTMENT TRUSTS AND REGULATED INVESTMENT COMPANIES Procedure and Administration § 55.6001-1 Notice or regulations requiring records, statements, and special returns. (a) In general. Any person subject to tax... retained so long as the contents thereof may become material in the administration of any internal...

  10. 78 FR 11279 - Loan Originator Compensation Requirements Under the Truth in Lending Act (Regulation Z)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-15

    ... first study how points and fees function in the market and the impact of this and other mortgage-related... http://research.stlouisfed.org/publications/review/article/5019 . \\4\\ U.S. Fin. Crisis Inquiry Comm'n... portfolio or sell the loan on the secondary market. \\34\\ In some cases, mortgage brokers use a...

  11. 78 FR 32547 - Loan Originator Compensation Requirements Under the Truth in Lending Act (Regulation Z...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ..., 2013, at 78 FR 11280, is effective January 10, 2014, with the exception of the amendments to 12 CFR...\\ Public Law 111-203, 124 Stat. 1376 (2010). \\2\\ 78 FR 11279 (Feb. 15, 2013). A. Title XIV Rulemaking... whether the provision should become effective sooner than January 2014.\\7\\ \\6\\ 77 FR 55272 (Sept. 7,...

  12. 25 CFR 101.10 - Federal Reserve Regulation Z and Fair Credit Reporting Act.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... subject to the provisions of Federal Reserve Regulation Z (Truth In Lending, 12 CFR part 226; Pub. L. 91... 25 Indians 1 2011-04-01 2011-04-01 false Federal Reserve Regulation Z and Fair Credit Reporting... ACTIVITIES LOANS TO INDIANS FROM THE REVOLVING LOAN FUND § 101.10 Federal Reserve Regulation Z and...

  13. 25 CFR 101.10 - Federal Reserve Regulation Z and Fair Credit Reporting Act.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... subject to the provisions of Federal Reserve Regulation Z (Truth In Lending, 12 CFR part 226; Pub. L. 91... 25 Indians 1 2010-04-01 2010-04-01 false Federal Reserve Regulation Z and Fair Credit Reporting... ACTIVITIES LOANS TO INDIANS FROM THE REVOLVING LOAN FUND § 101.10 Federal Reserve Regulation Z and...

  14. GP Supervisors' Experience in Supporting Self-Regulated Learning: A Balancing Act

    ERIC Educational Resources Information Center

    Sagasser, Margaretha H.; Kramer, Anneke W. M.; van Weel, Chris; van der Vleuten, Cees P. M.

    2015-01-01

    Self-regulated learning is essential for professional development and lifelong learning. As self-regulated learning has many inaccuracies, the need to support self-regulated learning has been recommended. Supervisors can provide such support. In a prior study trainees reported on the variation in received supervisor support. This study aims at…

  15. Foundations for the Future of Alberta's Metis Settlements. Report of the MacEwan Joint Metis-Government Committee to Review the Metis Betterment Act and Regulations.

    ERIC Educational Resources Information Center

    Alberta Ministry of Municipal Affairs, Edmonton.

    Prepared as a working document for officials of the Alberta (Canada) government, this report reviews the Metis Betterment Act and regulations made under the Act with one goal being to ensure that any proposals for a new Act would place the major responsibility for the political, social, economic, and cultural development of the settlements firmly…

  16. 25 CFR 309.1 - How do the regulations in this part carry out the Indian Arts and Crafts Act of 1990?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Arts and Crafts Act of 1990? 309.1 Section 309.1 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR PROTECTION OF INDIAN ARTS AND CRAFTS PRODUCTS § 309.1 How do the regulations in this part carry out the Indian Arts and Crafts Act of 1990? These regulations define the nature and Indian...

  17. 21 CFR 108.19 - Establishment of requirements for exemption from section 404 of the act.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... packing of the food necessary to protect the public health. Such regulations may be proposed by the... HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION EMERGENCY PERMIT CONTROL General... in any locality, be injurious to health, and that such injurious nature cannot be...

  18. 21 CFR 108.19 - Establishment of requirements for exemption from section 404 of the act.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... packing of the food necessary to protect the public health. Such regulations may be proposed by the... HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION EMERGENCY PERMIT CONTROL General... in any locality, be injurious to health, and that such injurious nature cannot be...

  19. The Regulation of Medical Computer Software as a “Device” under the Food, Drug, and Cosmetic Act

    PubMed Central

    Brannigan, Vincent

    1986-01-01

    Recent developments in computer software have raised the possibility that federal regulators may claim to control medical computer software as a “device” under the Food, Drug and Cosmetic Act. The purpose of this paper is to analyze the FDCA to determine whether computer software is included in the statutory scheme, examine constitutional arguments relating to computer software, and discuss regulatory principles that should be taken into account when deciding appropriate regulation. This paper is limited to computer program output used by humans in deciding appropriate medical therapy for a patient.

  20. The regulation of hazardous air pollutants under the Clean Air Act Amendments of 1990: Effects on the Portland cement industry

    SciTech Connect

    Mikols, E.H.; Dougherty, A.

    1996-07-01

    Title III of the 1990 Clean Air Act Amendments (CAAA) addresses the control of hazardous air pollutants (HAPs) from major sources of air pollution in the US. In the CAAA, Congress defined 189 compounds as hazardous air pollutants in need of additional control by the Environmental Protection Agency (EPA). Congress directed EPA to identify the major source categories which emit HAPs and to prepare regulations that would reduce and control future HAP emissions. This paper outlines the activities undertaken by EPA to regulate HAP emissions from Portland cement plants and the program developed by the Portland cement manufacturing industry to cope with Title III.

  1. DAY NEUTRAL FLOWERING does not act through GIGANTEA and FKF1 to regulate CONSTANS expression and flowering time.

    PubMed

    Morris, Karl; Jackson, Stephen P

    2010-09-01

    The regulation of CONSTANS (CO) gene expression and protein levels is the critical factor in determining a plant's response to photoperiod, flowering is induced when high levels of CO protein are present in the light. The regulation of CO transcription is mediated in part by GIGANTEA (GI), FKF1 and the CYCLING DOF FACTORS (CDFs) and factors affecting the levels of these proteins will also affect CO expression. The DAY NEUTRAL FLOWERING (DNF) protein is an E3 ligase involved in repressing CO expression in the early part of the day. In this article we present evidence to support the argument that DNF is not acting through the GI/FKF1/CDF regulatory mechanism to repress CO expression, but that it acts on another transcriptional activator of CO.

  2. 36 CFR 801.6 - Coordination with requirements under the National Environmental Policy Act (42 U.S.C. 4321 et seq.).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... underway and the final EIS should reflect the results of this process. Applicants are directed to 36 CFR... requirements under the National Environmental Policy Act (42 U.S.C. 4321 et seq.). 801.6 Section 801.6 Parks... National Environmental Policy Act (42 U.S.C. 4321 et seq.). The National Historic Preservation Act and...

  3. 36 CFR 801.6 - Coordination with requirements under the National Environmental Policy Act (42 U.S.C. 4321 et seq.).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... underway and the final EIS should reflect the results of this process. Applicants are directed to 36 CFR... requirements under the National Environmental Policy Act (42 U.S.C. 4321 et seq.). 801.6 Section 801.6 Parks... National Environmental Policy Act (42 U.S.C. 4321 et seq.). The National Historic Preservation Act and...

  4. 36 CFR 801.6 - Coordination with requirements under the National Environmental Policy Act (42 U.S.C. 4321 et seq.).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... underway and the final EIS should reflect the results of this process. Applicants are directed to 36 CFR... requirements under the National Environmental Policy Act (42 U.S.C. 4321 et seq.). 801.6 Section 801.6 Parks... National Environmental Policy Act (42 U.S.C. 4321 et seq.). The National Historic Preservation Act and...

  5. 36 CFR 801.6 - Coordination with requirements under the National Environmental Policy Act (42 U.S.C. 4321 et seq.).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... underway and the final EIS should reflect the results of this process. Applicants are directed to 36 CFR... requirements under the National Environmental Policy Act (42 U.S.C. 4321 et seq.). 801.6 Section 801.6 Parks... National Environmental Policy Act (42 U.S.C. 4321 et seq.). The National Historic Preservation Act and...

  6. 12 CFR 208.36 - Reporting requirements for State member banks subject to the Securities Exchange Act of 1934.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... recent fiscal year, and no foreign offices, may elect to substitute for the financial statements required... 10 of the Commission's Regulation S-X (17 CFR 210.10-01), in the Management's Discussion and Analysis... document filed with the Board. Each copy of the confidential portion shall contain the complete text of...

  7. 12 CFR 208.36 - Reporting requirements for State member banks subject to the Securities Exchange Act of 1934.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... recent fiscal year, and no foreign offices, may elect to substitute for the financial statements required... 10 of the Commission's Regulation S-X (17 CFR 210.10-01), in the Management's Discussion and Analysis... document filed with the Board. Each copy of the confidential portion shall contain the complete text of...

  8. 12 CFR 208.36 - Reporting requirements for State member banks subject to the Securities Exchange Act of 1934.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... recent fiscal year, and no foreign offices, may elect to substitute for the financial statements required... 10 of the Commission's Regulation S-X (17 CFR 210.10-01), in the Management's Discussion and Analysis... document filed with the Board. Each copy of the confidential portion shall contain the complete text of...

  9. 15 CFR Supplement No. 1 to Part 730 - Information Collection Requirements Under the Paperwork Reduction Act: OMB Control Numbers

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS GENERAL INFORMATION Pt. 730, Supp. 1... requirements for the Bureau of Industry and Security by the Office of Management and Budget (OMB), pursuant to...-Disclosure of Antiboycott Violations § 764.8. 0694-0133 Thermal Imaging Camera Reporting § 743.3...

  10. 15 CFR Supplement No. 1 to Part 730 - Information Collection Requirements Under the Paperwork Reduction Act: OMB Control Numbers

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS GENERAL INFORMATION Pt. 730, Supp. 1... requirements for the Bureau of Industry and Security by the Office of Management and Budget (OMB), pursuant to... Antiboycott Violations § 764.8. 0694-0133 Thermal Imaging Camera Reporting § 743.3 0694-0134 Procedure...

  11. Employee Retirement Income Security Act of 1974; rules and regulations for administration and enforcement; claims procedure--Department of Labor. Notice of proposed rulemaking.

    PubMed

    1998-09-01

    This document contains a proposed regulation revising the minimum requirements for benefit claims procedures of employee benefit plans covered by Title I of the Employee Retirement Income Security Act of 1974 (ERISA or the Act). This proposed regulation would establish new standards for the processing of group health disability, pension, and other employee benefit plan claims filed by participants and beneficiaries. In the case of group health plans, as well as certain plans providing disability benefits, the new standards are intended to ensure more timely benefit determinations, improved access to information on which a benefit determination is made, and greater assurance that participants and beneficiaries will be afforded a full and fair review of denied claims. If adopted as final, the proposed regulation would affect participants and beneficiaries of employee benefit plans, plan, fiduciaries, and others who assist in the provision of plan benefits, such as third-party benefits administrators and health service providers or health maintenance organizations that provide benefits to participants and beneficiaries of employee benefit plans.

  12. Ligand recognition by ActR, a TetR-like regulator of actinorhodin export.

    PubMed

    Tahlan, Kapil; Yu, Zhou; Xu, Ye; Davidson, Alan R; Nodwell, Justin R

    2008-11-21

    TetR-like transcriptional repressors interact with small-molecule ligands to control many facets of prokaryotic biology, including clinical antibiotic resistance. ActR is a TetR-like protein encoded in the biosynthetic gene cluster for the antibiotic actinorhodin and controls the expression of two actinorhodin exporters. We showed previously that actinorhodin and its precursor 4-dihydro-9-hydroxy-1-methyl-10-oxo-3-H-naphtho-[2,3-c]-pyran-3-(S)-acetic acid can bind ActR and prevent its interaction with DNA. Here, we compare ActR's interaction with naturally occurring and synthetic molecules to show that pathway intermediates bind to ActR 5- to 10-fold more tightly than actinorhodin itself, consistent with our suggestion that they are the biologically relevant triggers for actinorhodin export. We also find that the ligand-binding cavity of this protein can accommodate a surprisingly large diversity of ligands, many of which can release ActR from DNA in vitro and in vivo. These data suggest that the actR locus could be activated by, and perhaps adapted to confer resistance to other antibiotics.

  13. 78 FR 54403 - Removal of Transferred OTS Regulations Regarding Recordkeeping and Confirmation Requirements for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-04

    ...\\ \\2\\ 76 FR 39247 (July 6, 2011). Although section 312(b)(2)(B)(i)(II) of the Dodd-Frank Act, codified... them, as appropriate. \\3\\ 76 FR 47652 (Aug. 5, 2011). One of the OTS's rules transferred to the FDIC... confirmation requirements in appropriate circumstance.\\6\\ \\4\\ 44 FR 43260, 43261 (July 24, 1979). \\5\\ See 44...

  14. Technical guidance document for environmental requirements of commercial OTEC licensing regulations (15 CFR Part 981)

    SciTech Connect

    Not Available

    1981-09-01

    This document provides a potential OTEC applicant with the insights believed needed to satisfy the environmental information requirements of the regulations for licensing commercial OTEC facilities and plantships. This information should be used by applicants to define the site-specific details of the needed environmental assessment, and the details should then form a basis for pre-application consultations on the environmental requirements.

  15. 75 FR 14448 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-25

    ... HUMAN SERVICES Food and Drug Administration Food and Drug Administration Clinical Trial Requirements... announcing a public workshop entitled ``FDA Clinical Trial Requirements, Regulations, Compliance, and Good... representatives. The program will focus on the relationships among the FDA and clinical trial staff,...

  16. 76 FR 2827 - Regulated Navigation Area; Reporting Requirements for Barges Loaded With Certain Dangerous...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-18

    ... Regulated Navigation Area (RNA) established by 33 CFR 165.921 for barges loaded with certain dangerous... requirements, or repeal the RNA. This suspension of the CDC reporting requirements in no way relieves towing vessel operators and fleeting area managers responsible for CDC barges in the RNA from their...

  17. 75 FR 29456 - Acquisition Regulation: Subchapter E-General Contracting Requirements, Subchapter F-Special...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-26

    ... Acquisition Regulation: Subchapter E--General Contracting Requirements, Subchapter F--Special Categories of...) Subchapters E--General Contracting Requirements, F--Special Categories of Contracting, and G--Contract...: June 25, 2010. FOR FURTHER INFORMATION CONTACT: Barbara Binney at (202) 287-1340 or by e-mail,...

  18. 12 CFR 350.12 - Disclosure required by applicable banking or securities law or regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Disclosure required by applicable banking or securities law or regulations. 350.12 Section 350.12 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION... STATE NONMEMBER BANKS § 350.12 Disclosure required by applicable banking or securities law...

  19. 12 CFR 350.12 - Disclosure required by applicable banking or securities law or regulations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Disclosure required by applicable banking or securities law or regulations. 350.12 Section 350.12 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION... STATE NONMEMBER BANKS § 350.12 Disclosure required by applicable banking or securities law...

  20. 12 CFR 350.12 - Disclosure required by applicable banking or securities law or regulations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 5 2013-01-01 2013-01-01 false Disclosure required by applicable banking or securities law or regulations. 350.12 Section 350.12 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION... STATE NONMEMBER BANKS § 350.12 Disclosure required by applicable banking or securities law...