Science.gov

Sample records for act target entities

  1. 48 CFR 952.226-71 - Utilization of Energy Policy Act target entities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Utilization of Energy... Clauses 952.226-71 Utilization of Energy Policy Act target entities. As prescribed in 926.7007(b), insert the following clause: Utilization of Energy Policy Act Target Entities (JUN 1996) (a)...

  2. 48 CFR 952.226-71 - Utilization of Energy Policy Act target entities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Utilization of Energy... Clauses 952.226-71 Utilization of Energy Policy Act target entities. As prescribed in 926.7007(b), insert the following clause: Utilization of Energy Policy Act Target Entities (JUN 1996) (a)...

  3. 48 CFR 952.226-71 - Utilization of Energy Policy Act target entities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Utilization of Energy... DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.226-71 Utilization of Energy Policy Act target entities. As prescribed in 926.7007(b),...

  4. 48 CFR 952.226-71 - Utilization of Energy Policy Act target entities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Utilization of Energy... DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.226-71 Utilization of Energy Policy Act target entities. As prescribed in 926.7007(b),...

  5. 48 CFR 952.226-71 - Utilization of Energy Policy Act target entities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Utilization of Energy... DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.226-71 Utilization of Energy Policy Act target entities. As prescribed in 926.7007(b),...

  6. 17 CFR 230.157 - Small entities under the Securities Act for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false Small entities under the Securities Act for purposes of the Regulatory Flexibility Act. 230.157 Section 230.157 Commodity and... General § 230.157 Small entities under the Securities Act for purposes of the Regulatory Flexibility...

  7. 17 CFR 230.157 - Small entities under the Securities Act for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Small entities under the Securities Act for purposes of the Regulatory Flexibility Act. 230.157 Section 230.157 Commodity and... General § 230.157 Small entities under the Securities Act for purposes of the Regulatory Flexibility...

  8. 17 CFR 230.157 - Small entities under the Securities Act for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Small entities under the Securities Act for purposes of the Regulatory Flexibility Act. 230.157 Section 230.157 Commodity and... General § 230.157 Small entities under the Securities Act for purposes of the Regulatory Flexibility...

  9. 17 CFR 230.157 - Small entities under the Securities Act for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 2 2012-04-01 2012-04-01 false Small entities under the Securities Act for purposes of the Regulatory Flexibility Act. 230.157 Section 230.157 Commodity and... General § 230.157 Small entities under the Securities Act for purposes of the Regulatory Flexibility...

  10. 17 CFR 230.157 - Small entities under the Securities Act for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 3 2014-04-01 2014-04-01 false Small entities under the Securities Act for purposes of the Regulatory Flexibility Act. 230.157 Section 230.157 Commodity and... General § 230.157 Small entities under the Securities Act for purposes of the Regulatory Flexibility...

  11. 17 CFR 23.440 - Requirements for swap dealers acting as advisors to Special Entities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 1 2014-04-01 2014-04-01 false Requirements for swap dealers acting as advisors to Special Entities. 23.440 Section 23.440 Commodity and Securities Exchanges....440 Requirements for swap dealers acting as advisors to Special Entities. (a) Acts as an advisor to...

  12. 17 CFR 23.440 - Requirements for swap dealers acting as advisors to Special Entities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Requirements for swap dealers acting as advisors to Special Entities. 23.440 Section 23.440 Commodity and Securities Exchanges....440 Requirements for swap dealers acting as advisors to Special Entities. (a) Acts as an advisor to...

  13. 17 CFR 260.0-7 - Small entities for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Small entities for purposes of the Regulatory Flexibility Act. 260.0-7 Section 260.0-7 Commodity and Securities Exchanges SECURITIES... of the Commission § 260.0-7 Small entities for purposes of the Regulatory Flexibility Act....

  14. 17 CFR 260.0-7 - Small entities for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Small entities for purposes of the Regulatory Flexibility Act. 260.0-7 Section 260.0-7 Commodity and Securities Exchanges SECURITIES... of the Commission § 260.0-7 Small entities for purposes of the Regulatory Flexibility Act....

  15. 17 CFR 260.0-7 - Small entities for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Small entities for purposes of the Regulatory Flexibility Act. 260.0-7 Section 260.0-7 Commodity and Securities Exchanges SECURITIES... of the Commission § 260.0-7 Small entities for purposes of the Regulatory Flexibility Act....

  16. 17 CFR 260.0-7 - Small entities for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Small entities for purposes of the Regulatory Flexibility Act. 260.0-7 Section 260.0-7 Commodity and Securities Exchanges SECURITIES... of the Commission § 260.0-7 Small entities for purposes of the Regulatory Flexibility Act....

  17. 17 CFR 260.0-7 - Small entities for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Small entities for purposes of the Regulatory Flexibility Act. 260.0-7 Section 260.0-7 Commodity and Securities Exchanges SECURITIES... of the Commission § 260.0-7 Small entities for purposes of the Regulatory Flexibility Act....

  18. 17 CFR 240.0-10 - Small entities under the Securities Exchange Act for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Small entities under the Securities Exchange Act for purposes of the Regulatory Flexibility Act. 240.0-10 Section 240.0-10 Commodity... Regulatory Flexibility Act. For purposes of Commission rulemaking in accordance with the provisions...

  19. 17 CFR 240.0-10 - Small entities under the Securities Exchange Act for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Small entities under the Securities Exchange Act for purposes of the Regulatory Flexibility Act. 240.0-10 Section 240.0-10 Commodity... Regulatory Flexibility Act. For purposes of Commission rulemaking in accordance with the provisions...

  20. 17 CFR 275.0-7 - Small entities under the Investment Advisers Act for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Small entities under the Investment Advisers Act for purposes of the Regulatory Flexibility Act. 275.0-7 Section 275.0-7 Commodity and... Regulatory Flexibility Act. (a) For purposes of Commission rulemaking in accordance with the provisions...

  1. 17 CFR 270.0-10 - Small entities under the Investment Company Act for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Small entities under the Investment Company Act for purposes of the Regulatory Flexibility Act. 270.0-10 Section 270.0-10 Commodity... Regulatory Flexibility Act. (a) General. For purposes of Commission rulemaking in accordance with...

  2. 17 CFR 270.0-10 - Small entities under the Investment Company Act for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Small entities under the Investment Company Act for purposes of the Regulatory Flexibility Act. 270.0-10 Section 270.0-10 Commodity... Regulatory Flexibility Act. (a) General. For purposes of Commission rulemaking in accordance with...

  3. 17 CFR 240.0-10 - Small entities under the Securities Exchange Act for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Small entities under the Securities Exchange Act for purposes of the Regulatory Flexibility Act. 240.0-10 Section 240.0-10 Commodity... Regulatory Flexibility Act. For purposes of Commission rulemaking in accordance with the provisions...

  4. 17 CFR 275.0-7 - Small entities under the Investment Advisers Act for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Small entities under the Investment Advisers Act for purposes of the Regulatory Flexibility Act. 275.0-7 Section 275.0-7 Commodity and... Regulatory Flexibility Act. (a) For purposes of Commission rulemaking in accordance with the provisions...

  5. 17 CFR 270.0-10 - Small entities under the Investment Company Act for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Small entities under the Investment Company Act for purposes of the Regulatory Flexibility Act. 270.0-10 Section 270.0-10 Commodity... Regulatory Flexibility Act. (a) General. For purposes of Commission rulemaking in accordance with...

  6. 17 CFR 240.0-10 - Small entities under the Securities Exchange Act for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Small entities under the Securities Exchange Act for purposes of the Regulatory Flexibility Act. 240.0-10 Section 240.0-10 Commodity... Regulatory Flexibility Act. For purposes of Commission rulemaking in accordance with the provisions...

  7. 17 CFR 275.0-7 - Small entities under the Investment Advisers Act for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Small entities under the Investment Advisers Act for purposes of the Regulatory Flexibility Act. 275.0-7 Section 275.0-7 Commodity and... Regulatory Flexibility Act. (a) For purposes of Commission rulemaking in accordance with the provisions...

  8. 17 CFR 270.0-10 - Small entities under the Investment Company Act for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Small entities under the Investment Company Act for purposes of the Regulatory Flexibility Act. 270.0-10 Section 270.0-10 Commodity... Regulatory Flexibility Act. (a) General. For purposes of Commission rulemaking in accordance with...

  9. 17 CFR 270.0-10 - Small entities under the Investment Company Act for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Small entities under the Investment Company Act for purposes of the Regulatory Flexibility Act. 270.0-10 Section 270.0-10 Commodity... Regulatory Flexibility Act. (a) General. For purposes of Commission rulemaking in accordance with...

  10. 17 CFR 275.0-7 - Small entities under the Investment Advisers Act for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Small entities under the Investment Advisers Act for purposes of the Regulatory Flexibility Act. 275.0-7 Section 275.0-7 Commodity and... Regulatory Flexibility Act. (a) For purposes of Commission rulemaking in accordance with the provisions...

  11. 17 CFR 275.0-7 - Small entities under the Investment Advisers Act for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Small entities under the Investment Advisers Act for purposes of the Regulatory Flexibility Act. 275.0-7 Section 275.0-7 Commodity and... Regulatory Flexibility Act. (a) For purposes of Commission rulemaking in accordance with the provisions...

  12. 17 CFR 250.110 - Small entities for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Small entities for purposes of the Regulatory Flexibility Act. 250.110 Section 250.110 Commodity and Securities Exchanges SECURITIES... OF 1935 Miscellaneous Rules § 250.110 Small entities for purposes of the Regulatory Flexibility...

  13. 17 CFR 250.110 - Small entities for purposes of the Regulatory Flexibility Act.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Small entities for purposes of the Regulatory Flexibility Act. 250.110 Section 250.110 Commodity and Securities Exchanges SECURITIES... OF 1935 Miscellaneous Rules § 250.110 Small entities for purposes of the Regulatory Flexibility...

  14. 78 FR 42484 - Small Entity Size Standards Under the Regulatory Flexibility Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board 49 CFR Chapter X Small Entity Size Standards Under the Regulatory Flexibility... standards for purposes of the Regulatory Flexibility Act (RFA) and request for public comment. SUMMARY:...

  15. 77 FR 27831 - List of Participating Countries and Entities Under the Clean Diamond Trade Act of 2003

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-11

    ... Participating Countries and Entities Under the Clean Diamond Trade Act of 2003 AGENCY: Department of State... Entities eligible for trade in rough diamonds under the Clean Diamond Trade Act of 2003, and their... Diamonds, Bureau of Economic, Energy, and Business Affairs, Department of State (202)...

  16. 78 FR 52553 - Privacy Act of 1974; Department of Homeland Security/ALL-035 Common Entity Index Prototype System...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ... SECURITY Office of the Secretary Privacy Act of 1974; Department of Homeland Security/ALL-035 Common Entity... titled, ``Department of Homeland Security/ ALL--035 Common Entity Index Prototype System of Records.... Instructions: All submissions received must include the agency name and docket number for this rulemaking....

  17. 75 FR 62916 - Persons and Entities on Whom Sanctions Have Been Imposed Under the Iran Sanctions Act of 1996

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-13

    ... and Entities on Whom Sanctions Have Been Imposed Under the Iran Sanctions Act of 1996 AGENCY... Intertrade Company (NICO) has engaged in a sanctionable investment described in section 5(a)(1) of the Iran... enactment of the Comprehensive Iran Sanctions, Accountability, and Divestment Act of 2010...

  18. 76 FR 18821 - Persons and Entities on Whom Sanctions Have Been Imposed Under the Iran Sanctions Act of 1996

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    ... and Entities on Whom Sanctions Have Been Imposed Under the Iran Sanctions Act of 1996 AGENCY... engaged in a sanctionable investment described in section 5(a)(1) of the Iran Sanctions Act of 1996 (ISA... section 5(a) of the ISA, as in effect on the day before the date of enactment of the Comprehensive...

  19. 15 CFR 744.11 - License requirements that apply to entities acting contrary to the national security or foreign...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... entities acting contrary to the national security or foreign policy interests of the United States. 744.11... national security or foreign policy interests of the United States. BIS may impose foreign policy export... of being or becoming involved in activities that are contrary to the national security or...

  20. 15 CFR 744.11 - License requirements that apply to entities acting contrary to the national security or foreign...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... entities acting contrary to the national security or foreign policy interests of the United States. 744.11... national security or foreign policy interests of the United States. BIS may impose foreign policy export... of being or becoming involved in activities that are contrary to the national security or...

  1. 15 CFR 744.11 - License requirements that apply to entities acting contrary to the national security or foreign...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... section by adding an entity to the Entity List (Supp. No. 4 to this part) with a reference to this section and by stating on the Entity List the license requirements and license application review policy that apply to that entity. BIS may remove an entity from the Entity List if it is no longer engaged in...

  2. Patient protection and Affordable Care Act; data collection to support standards related to essential health benefits; recognition of entities for the accreditation of qualified health plans. Final rule.

    PubMed

    2012-07-20

    This final rule establishes data collection standards necessary to implement aspects of section 1302 of the Patient Protection and Affordable Care Act (Affordable Care Act), which directs the Secretary of Health and Human Services to define essential health benefits. This final rule outlines the data on applicable plans to be collected from certain issuers to support the definition of essential health benefits. This final rule also establishes a process for the recognition of accrediting entities for purposes of certification of qualified health plans.

  3. 76 FR 37632 - Addition of Certain Persons on the Entity List: Addition of Persons Acting Contrary to the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-28

    ... amends the Export Administration Regulations (EAR) by adding eight persons to the Entity List (Supplement No. 4 to part 744) on the basis of section 744.11 of the EAR. The persons who are added to the Entity... criteria set forth in certain sections of part 744 (Control Policy: End-User and End-Use Based) of the...

  4. 77 FR 23114 - Addition of Certain Persons on the Entity List: Addition of Persons Acting Contrary to the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-18

    ... amends the Export Administration Regulations (EAR) by adding three persons to the Entity List. The... of part 744 (Control Policy: End-User and End-Use Based) of the EAR. The ERC, composed of... foreign policy interests of the United States) of the EAR. The three entries added to the Entity...

  5. 76 FR 44259 - Addition of Certain Persons on the Entity List: Addition of Persons Acting Contrary to the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-25

    ... amends the Export Administration Regulations (EAR) by adding six persons to the Entity List (Supplement No. 4 to Part 744) on the basis of section 744.11 of the EAR. The persons who are added to the Entity... (Control Policy: End-User and End-Use Based) of the EAR. The End-User Review Committee (ERC), composed...

  6. Moving Hands, Moving Entities

    ERIC Educational Resources Information Center

    Setti, Annalisa; Borghi, Anna M.; Tessari, Alessia

    2009-01-01

    In this study we investigated with a priming paradigm whether uni and bimanual actions presented as primes differently affected language processing. Animals' (self-moving entities) and plants' (not self-moving entities) names were used as targets. As prime we used grasping hands, presented both as static images and videos. The results showed an…

  7. 15 CFR 744.11 - License requirements that apply to entities acting contrary to the national security or foreign...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Secretary of State as having repeatedly provided support for acts of international terrorism. (3... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false License requirements that apply to... Section 744.11 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade...

  8. 50 CFR 648.121 - Scup Annual Catch Target (ACT).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... shall identify and review the relevant sources of management uncertainty to recommend ACTs for the... Committee recommendations shall identify the specific sources of management uncertainty that were considered, technical approaches to mitigating these sources of uncertainty, and any additional relevant...

  9. 50 CFR 648.121 - Scup Annual Catch Target (ACT).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... shall identify and review the relevant sources of management uncertainty to recommend ACTs for the... Committee recommendations shall identify the specific sources of management uncertainty that were considered, technical approaches to mitigating these sources of uncertainty, and any additional relevant...

  10. 50 CFR 648.121 - Scup Annual Catch Target (ACT).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... shall identify and review the relevant sources of management uncertainty to recommend ACTs for the... Committee recommendations shall identify the specific sources of management uncertainty that were considered, technical approaches to mitigating these sources of uncertainty, and any additional relevant...

  11. 48 CFR 952.226-73 - Energy Policy Act target group certification.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Energy Policy Act target... ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.226-73 Energy Policy Act target group certification. As prescribed in 926.7007(d), insert...

  12. 48 CFR 952.226-73 - Energy Policy Act target group certification.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Energy Policy Act target... ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.226-73 Energy Policy Act target group certification. As prescribed in 926.7007(d), insert...

  13. 48 CFR 952.226-73 - Energy Policy Act target group certification.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Energy Policy Act target... ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.226-73 Energy Policy Act target group certification. As prescribed in 926.7007(d), insert...

  14. 48 CFR 952.226-73 - Energy Policy Act target group certification.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Energy Policy Act target... ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.226-73 Energy Policy Act target group certification. As prescribed in 926.7007(d), insert...

  15. 50 CFR 648.291 - Tilefish Annual Catch Target (ACT).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Committee shall identify and review the relevant sources of management uncertainty to recommend an ACT as... identify the specific sources of management uncertainty that were considered, technical approaches to mitigating these sources of uncertainty, and any additional relevant information considered in the...

  16. 50 CFR 648.291 - Tilefish Annual Catch Target (ACT).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Committee shall identify and review the relevant sources of management uncertainty to recommend an ACT as... identify the specific sources of management uncertainty that were considered, technical approaches to mitigating these sources of uncertainty, and any additional relevant information considered in the...

  17. 50 CFR 648.291 - Tilefish Annual Catch Target (ACT).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Committee shall identify and review the relevant sources of management uncertainty to recommend an ACT as... identify the specific sources of management uncertainty that were considered, technical approaches to mitigating these sources of uncertainty, and any additional relevant information considered in the...

  18. Distribution of certain drug products by registered blood establishments and comprehensive hemophilia diagnostic treatment centers that qualify as health care entities; Prescription Drug Marketing Act of 1987; Prescription Drug Amendments of 1992; policies, requirements and administrative procedures. Final rule.

    PubMed

    2008-10-09

    The Food and Drug Administration (FDA) is amending its regulations to allow certain registered blood establishments and comprehensive hemophilia diagnostic treatment centers that are also health care entities to distribute certain drug products. The final rule amends limited provisions of the regulations implementing the Prescription Drug Marketing Act of 1987 (PDMA), as modified by the Prescription Drug Amendments of 1992 (PDA). These regulations, among other things, restrict the sale, purchase, or trade of, or the offer to sell, purchase, or trade, prescription drugs purchased by hospitals and other health care entities.

  19. Dual-Acting Compounds Targeting Endocannabinoid and Endovanilloid Systems—A Novel Treatment Option for Chronic Pain Management

    PubMed Central

    Malek, Natalia; Starowicz, Katarzyna

    2016-01-01

    Compared with acute pain that arises suddenly in response to a specific injury and is usually treatable, chronic pain persists over time, and is often resistant to medical treatment. Because of the heterogeneity of chronic pain origins, satisfactory therapies for its treatment are lacking, leading to an urgent need for the development of new treatments. The leading approach in drug design is selective compounds, though they are often less effective and require chronic dosing with many side effects. Herein, we review novel approaches to drug design for the treatment of chronic pain represented by dual-acting compounds, which operate at more than one biological target. A number of studies suggest the involvement of the cannabinoid and vanilloid receptors in pain. Interestingly cannabinoid system is in interrelation with other systems that comprise lipid mediators: prostaglandins, produced by COX enzyme. Therefore, in the present review, we summarize the role of dual-acting molecules (FAAH/TRPV1 and FAAH/COX-2 inhibitors) that interact with endocannabinoid and endovanillinoid systems and act as analgesics by elevating the endogenously produced endocannabinoids and dampening the production of pro-inflammatory prostaglandins. The plasticity of the endocannabinoid system (ECS) and the ability of a single chemical entity to exert an activity on two receptor systems has been developed and extensively investigated. Here, we review up-to-date pharmacological studies on compounds interacting with FAAH enzyme together with TRPV1 receptor or COX-2 enzyme respectively. Multi-target pharmacological intervention for treating pain may lead to the development of original and efficient treatments. PMID:27582708

  20. Identifying the macromolecular targets of de novo-designed chemical entities through self-organizing map consensus.

    PubMed

    Reker, Daniel; Rodrigues, Tiago; Schneider, Petra; Schneider, Gisbert

    2014-03-18

    De novo molecular design and in silico prediction of polypharmacological profiles are emerging research topics that will profoundly affect the future of drug discovery and chemical biology. The goal is to identify the macromolecular targets of new chemical agents. Although several computational tools for predicting such targets are publicly available, none of these methods was explicitly designed to predict target engagement by de novo-designed molecules. Here we present the development and practical application of a unique technique, self-organizing map-based prediction of drug equivalence relationships (SPiDER), that merges the concepts of self-organizing maps, consensus scoring, and statistical analysis to successfully identify targets for both known drugs and computer-generated molecular scaffolds. We discovered a potential off-target liability of fenofibrate-related compounds, and in a comprehensive prospective application, we identified a multitarget-modulating profile of de novo designed molecules. These results demonstrate that SPiDER may be used to identify innovative compounds in chemical biology and in the early stages of drug discovery, and help investigate the potential side effects of drugs and their repurposing options.

  1. Identifying the macromolecular targets of de novo-designed chemical entities through self-organizing map consensus

    PubMed Central

    Reker, Daniel; Rodrigues, Tiago; Schneider, Petra; Schneider, Gisbert

    2014-01-01

    De novo molecular design and in silico prediction of polypharmacological profiles are emerging research topics that will profoundly affect the future of drug discovery and chemical biology. The goal is to identify the macromolecular targets of new chemical agents. Although several computational tools for predicting such targets are publicly available, none of these methods was explicitly designed to predict target engagement by de novo-designed molecules. Here we present the development and practical application of a unique technique, self-organizing map–based prediction of drug equivalence relationships (SPiDER), that merges the concepts of self-organizing maps, consensus scoring, and statistical analysis to successfully identify targets for both known drugs and computer-generated molecular scaffolds. We discovered a potential off-target liability of fenofibrate-related compounds, and in a comprehensive prospective application, we identified a multitarget-modulating profile of de novo designed molecules. These results demonstrate that SPiDER may be used to identify innovative compounds in chemical biology and in the early stages of drug discovery, and help investigate the potential side effects of drugs and their repurposing options. PMID:24591595

  2. 78 FR 66105 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... entities whose property and interests in property have been blocked pursuant to the Foreign Narcotics... program targeting the activities of significant foreign narcotics traffickers and their organizations on...

  3. 78 FR 8701 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... entity whose property and interests in property have been blocked pursuant to the Foreign Narcotics... program targeting the activities of significant foreign narcotics traffickers and their organizations on...

  4. 77 FR 58912 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-24

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... entity whose property and interests in property have been blocked pursuant to the Foreign Narcotics... program targeting the activities of significant foreign narcotics traffickers and their organizations on...

  5. 77 FR 838 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-06

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... entities) whose property and interests in property have been blocked pursuant to the Foreign Narcotics... program targeting the activities of significant foreign narcotics traffickers and their organizations on...

  6. 77 FR 69706 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-20

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... entities whose property and interests in property have been blocked pursuant to the Foreign Narcotics... program targeting the activities of significant foreign narcotics traffickers and their organizations on...

  7. 77 FR 4400 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-27

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... entities whose property and interests in property have been blocked pursuant to the Foreign Narcotics... establishes a program targeting the activities of significant foreign narcotics traffickers and...

  8. 77 FR 38140 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-26

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... entities) whose property and interests in property have been blocked pursuant to the Foreign Narcotics... program targeting the activities of significant foreign narcotics traffickers and their organizations on...

  9. 78 FR 62946 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... entity whose property and interests in property have been blocked pursuant to the Foreign Narcotics... program targeting the activities of significant foreign narcotics traffickers and their organizations on...

  10. 76 FR 10668 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-25

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... entities whose property and interests in property have been blocked pursuant to the Foreign Narcotics... program targeting the activities of significant foreign narcotics traffickers and their organizations on...

  11. Distribution of blood derivatives by registered blood establishments that qualify as health care entities; Prescription Drug Marketing Act of 1987; Prescription Drug Amendments of 1992; delay of applicability date. Final rule; delay of applicability date.

    PubMed

    2006-11-13

    The Food and Drug Administration (FDA) is further delaying, until December 1, 2008, the applicability date of a certain requirement of a final rule published in the Federal Register of December 3, 1999 (64 FR 67720) (the final rule). The final rule implements the Prescription Drug Marketing Act of 1987 (PDMA), as modified by the Prescription Drug Amendments of 1992 (PDA), and the Food and Drug Administration Modernization Act of 1997 (the Modernization Act). The provisions of the final rule became effective on December 4, 2000, except for certain provisions whose effective or applicability dates were delayed in five subsequent Federal Register notices, until December 1, 2006. The provision with the delayed applicability date would prohibit wholesale distribution of blood derivatives by registered blood establishments that meet the definition of a "health care entity." In the Federal Register of February 1, 2006 (71 FR 5200), FDA published a proposed rule specific to the distribution of blood derivatives by registered blood establishments that qualify as health care entities (the proposed rule). The proposed rule would amend certain limited provisions of the final rule to allow certain registered blood establishments that qualify as health care entities to distribute blood derivatives. In response to the proposed rule, FDA received substantive comments. As explained in the SUPPLEMENTARY INFORMATION section of this document, further delaying the applicability of Sec. 203.3(q) (21 CFR 203.3(q)) to the wholesale distribution of blood derivatives by health care entities is necessary to give the agency additional time to address comments on the proposed rule, consider whether regulatory changes are appropriate, and, if so, to initiate such changes.

  12. 42 CFR 438.808 - Exclusion of entities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Exclusion of entities. (a) General rule. FFP is available in payments under MCO contracts only if the State excludes from the contracts any entities described in paragraph (b) of this section. (b) Entities that must... certain crimes as described in section 1128(b)(8)(B) of the Act. (3) An entity that employs or...

  13. The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases--a review.

    PubMed

    Basso, Luiz Augusto; da Silva, Luiz Hildebrando Pereira; Fett-Neto, Arthur Germano; de Azevedo, Walter Filgueira; Moreira, Icaro de Souza; Palma, Mário Sérgio; Calixto, João Batista; Astolfi Filho, Spartaco; dos Santos, Ricardo Ribeiro; Soares, Milena Botelho Pereira; Santos, Diógenes Santiago

    2005-10-01

    The modern approach to the development of new chemical entities against complex diseases, especially the neglected endemic diseases such as tuberculosis and malaria, is based on the use of defined molecular targets. Among the advantages, this approach allows (i) the search and identification of lead compounds with defined molecular mechanisms against a defined target (e.g. enzymes from defined pathways), (ii) the analysis of a great number of compounds with a favorable cost/benefit ratio, (iii) the development even in the initial stages of compounds with selective toxicity (the fundamental principle of chemotherapy), (iv) the evaluation of plant extracts as well as of pure substances. The current use of such technology, unfortunately, is concentrated in developed countries, especially in the big pharma. This fact contributes in a significant way to hamper the development of innovative new compounds to treat neglected diseases. The large biodiversity within the territory of Brazil puts the country in a strategic position to develop the rational and sustained exploration of new metabolites of therapeutic value. The extension of the country covers a wide range of climates, soil types, and altitudes, providing a unique set of selective pressures for the adaptation of plant life in these scenarios. Chemical diversity is also driven by these forces, in an attempt to best fit the plant communities to the particular abiotic stresses, fauna, and microbes that co-exist with them. Certain areas of vegetation (Amazonian Forest, Atlantic Forest, Araucaria Forest, Cerrado-Brazilian Savanna, and Caatinga) are rich in species and types of environments to be used to search for natural compounds active against tuberculosis, malaria, and chronic-degenerative diseases. The present review describes some strategies to search for natural compounds, whose choice can be based on ethnobotanical and chemotaxonomical studies, and screen for their ability to bind to immobilized drug targets

  14. Results of thermal test of metallic molybdenum disk target and fast-acting valve testing

    SciTech Connect

    Virgo, M.; Chemerisov, S.; Gromov, R.; Jonah, C.; Vandegrift, G. F.

    2016-12-01

    This report describes the irradiation conditions for thermal testing of helium-cooled metallic disk targets that was conducted on March 9, 2016, at the Argonne National Laboratory electron linac. The four disks in this irradiation were pressed and sintered by Oak Ridge National Laboratory from molybdenum metal powder. Two of those disks were instrumented with thermocouples. Also reported are results of testing a fast-acting-valve system, which was designed to protect the accelerator in case of a target-window failure.

  15. 50 CFR 648.231 - Spiny dogfish Annual Catch Target (ACT) and Total Allowable Level of Landings (TAL).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Spiny dogfish Annual Catch Target (ACT... OF THE NORTHEASTERN UNITED STATES Management Measures for the Spiny Dogfish Fishery § 648.231 Spiny dogfish Annual Catch Target (ACT) and Total Allowable Level of Landings (TAL). (a) The Spiny...

  16. 50 CFR 648.231 - Spiny dogfish Annual Catch Target (ACT) and Total Allowable Level of Landings (TAL).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Spiny dogfish Annual Catch Target (ACT... OF THE NORTHEASTERN UNITED STATES Management Measures for the Spiny Dogfish Fishery § 648.231 Spiny dogfish Annual Catch Target (ACT) and Total Allowable Level of Landings (TAL). (a) The Spiny...

  17. 50 CFR 648.231 - Spiny dogfish Annual Catch Target (ACT) and Total Allowable Level of Landings (TAL).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Spiny dogfish Annual Catch Target (ACT... OF THE NORTHEASTERN UNITED STATES Management Measures for the Spiny Dogfish Fishery § 648.231 Spiny dogfish Annual Catch Target (ACT) and Total Allowable Level of Landings (TAL). (a) The Spiny...

  18. 50 CFR 648.53 - Acceptable biological catch (ABC), annual catch limits (ACL), annual catch targets (ACT), DAS...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... catch limits (ACL), annual catch targets (ACT), DAS allocations, and individual fishing quotas (IFQ... limits (ACL), annual catch targets (ACT), DAS allocations, and individual fishing quotas (IFQ). (a... limited access scallop fishery shall be allocated 94.5 percent of the ACL specified in paragraph (a)(1)...

  19. 50 CFR 622.58 - Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs). 622.58 Section 622.58 Wildlife and Fisheries FISHERY... Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs). (a) Royal...

  20. 50 CFR 622.251 - Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs). 622.251 Section 622.251 Wildlife and Fisheries FISHERY... § 622.251 Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs)....

  1. 50 CFR 622.251 - Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs). 622.251 Section 622.251 Wildlife and Fisheries FISHERY... § 622.251 Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs)....

  2. 50 CFR 622.388 - Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs). 622.388 Section 622.388 Wildlife and Fisheries FISHERY... Mexico and South Atlantic) § 622.388 Annual catch limits (ACLs), annual catch targets (ACTs),...

  3. 50 CFR 622.388 - Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs). 622.388 Section 622.388 Wildlife and Fisheries FISHERY... Mexico and South Atlantic) § 622.388 Annual catch limits (ACLs), annual catch targets (ACTs),...

  4. 50 CFR 622.58 - Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs). 622.58 Section 622.58 Wildlife and Fisheries FISHERY... Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs). (a) Royal...

  5. SLC7A5 act as a potential leukemic transformation target gene in myelodysplastic syndrome

    PubMed Central

    Ma, Yan; Song, Jing; Chen, Bobin; Xu, Xiaoping; Lin, Guowei

    2016-01-01

    Objective Myelodysplastic syndromes (MDS) are a heterogenous group of clonal hematopoietic stem cell disorders characterized by increased risk of leukemic transformation. This study identifies microRNAs(miRNA) and miRNA targets that might represent leukemic transformation markers for MDS. Methods Based on our previously established nested case-control study cohort of MDS patients, we chose paired patients to undergo Angilent 8 × 15K human miRNA microarrays. Target prediction analysis was administrated using targetscan 5.1 software. We further investigated the function of target gene in MDS cell line using siRNA method, including cell proliferation, cell apoptosis, cell cycle and electron microscope. Results Finally we screened a subset of 7 miRNAs to be significantly differentially expressed between the case (at the end of follow up with leukemic transformation) and control group (at the end of follow up without leukemic transformation). Target prediction analysis revealed SLC7A5 was the common target gene of these 7 miRNAs. Further study on the function of SLC7A5 gene in SKM-1 cell line showed that downregulation of SLC7A5 inhibited SKM-1 cells proliferation, increased apoptosis and caused cell cycle arrest in the G0/G1 stage. Conclusion Our data indicate that SLC7A5 gene may act as a potential leukemic transformation target gene in MDS. PMID:26657287

  6. Acoustic Cluster Therapy (ACT)--A novel concept for ultrasound mediated, targeted drug delivery.

    PubMed

    Sontum, Per; Kvåle, Svein; Healey, Andrew John; Skurtveit, Roald; Watanabe, Rira; Matsumura, Manabu; Østensen, Jonny

    2015-11-30

    A novel approach for ultrasound (US) mediated drug delivery - Acoustic Cluster Therapy (ACT) - is proposed, and basic characteristics of the ACT formulation are elucidated. The concept comprises administration of free flowing clusters of negatively charged microbubbles and positively charged microdroplets. The clusters are activated within the target pathology by diagnostic US, undergo an ensuing liquid-to-gas phase shift and transiently deposit 20-30 μm large bubbles in the microvasculature, occluding blood flow for ∼5-10 min. Further application of US will induce biomechanical effects that increases the vascular permeability, leading to a locally enhanced extravasation of components from the vascular compartment (e.g. released or co-administered drugs). Methodologies are detailed for determination of vital in-vitro characteristics of the ACT compound; cluster concentration and size distribution. It is shown how these attributes can be engineered through various formulation parameters, and their significance as predictors of biological behaviour, such as deposit characteristics, is demonstrated by US imaging in a dog model. Furthermore, in-vivo properties of the activated ACT bubbles are studied by intravital microscopy in a rat model, confirming the postulated behaviour of the concept.

  7. The science of direct-acting antiviral and host-targeted agent therapy.

    PubMed

    Pawlotsky, Jean-Michel

    2012-01-01

    Direct-acting antiviral drugs targeting two major steps of the HCV life cycle, polyprotein processing and replication, and cyclophilin inhibitors, that target a host cell protein required to interact with the replication complex, have reached clinical development. In order to achieve a sustained virological response, that is, a cure of the HCV infection, it is necessary to shut down virus production, to maintain viral inhibition throughout treatment and to induce a significant, slower second-phase decline in HCV RNA levels that leads to definitive clearance of infected cells. Recent findings suggest that the interferon era is coming to an end in hepatitis C therapy and HCV infection can be cured by all-oral interferon-free treatment regimens within 12 to 24 weeks. Further results are awaited that will allow the establishment of an ideal first-line all-oral, interferon-free treatment regimen for patients with chronic HCV infection.

  8. Pharmacodynamics of long-acting folic acid-receptor targeted ritonavir boosted atazanavir nanoformulations

    PubMed Central

    Puligujja, Pavan; Balkundi, Shantanu; Kendrick, Lindsey; Baldridge, Hannah; Hilaire, James; Bade, Aditya N.; Dash, Prasanta K.; Zhang, Gang; Poluektova, Larisa; Gorantla, Santhi; Liu, Xin-Ming; Ying, Tianlei; Feng, Yang; Wang, Yanping; Dimitrov, Dimiter S.; McMillan, JoEllyn M.; Gendelman, Howard E.

    2014-01-01

    Long-acting nanoformulated antiretroviral therapy (nanoART) that target monocyte-macrophage could improve the drug’s half-life and protein binding capacities while facilitating cell and tissue depots. To this end, ART nanoparticles that target the folic acid (FA) receptor and permit cell-based drug depots were examined using pharmacokinetic and pharmacodynamic (PD) tests. FA receptor-targeted poloxamer 407 nanocrystals, containing ritonavir-boosted atazanavir (ATV/r), significantly affected several therapeutic factors: drug bioavailability increased as much as 5 times and PD activity improved as much as 100 times. Drug particles administered to human peripheral blood lymphocyte reconstituted NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ mice and infected with HIV-1ADA at a tissue culture infective dose50 of 104 infectious viral particles/ml led to ATV/r drug concentrations that paralleled FA receptor beta staining in both the macrophage-rich parafollicular areas of spleen and lymph nodes. Drug levels were higher in these tissues than what could be achieved by either native drug or untargeted nanoART particles. The data also mirrored potent reductions in viral loads, tissue viral RNA and numbers of HIV-1p24+ cells in infected and treated animals. We conclude that FA-P407 coating of ART nanoparticles readily facilitate drug carriage and facilitate antiretroviral responses. PMID:25522973

  9. Pharmacodynamics of long-acting folic acid-receptor targeted ritonavir-boosted atazanavir nanoformulations.

    PubMed

    Puligujja, Pavan; Balkundi, Shantanu S; Kendrick, Lindsey M; Baldridge, Hannah M; Hilaire, James R; Bade, Aditya N; Dash, Prasanta K; Zhang, Gang; Poluektova, Larisa Y; Gorantla, Santhi; Liu, Xin-Ming; Ying, Tianlei; Feng, Yang; Wang, Yanping; Dimitrov, Dimiter S; McMillan, JoEllyn M; Gendelman, Howard E

    2015-02-01

    Long-acting nanoformulated antiretroviral therapy (nanoART) that targets monocyte-macrophages could improve the drug's half-life and protein-binding capacities while facilitating cell and tissue depots. To this end, ART nanoparticles that target the folic acid (FA) receptor and permit cell-based drug depots were examined using pharmacokinetic and pharmacodynamic (PD) tests. FA receptor-targeted poloxamer 407 nanocrystals, containing ritonavir-boosted atazanavir (ATV/r), significantly increased drug bioavailability and PD by five and 100 times, respectively. Drug particles administered to human peripheral blood lymphocyte reconstituted NOD.Cg-Prkdc(scid)Il2rg(tm1Wjl)/SzJ mice and infected with HIV-1ADA led to ATV/r drug concentrations that paralleled FA receptor beta staining in both the macrophage-rich parafollicular areas of spleen and lymph nodes. Drug levels were higher in these tissues than what could be achieved by either native drug or untargeted nanoART particles. The data also mirrored potent reductions in viral loads, tissue viral RNA and numbers of HIV-1p24+ cells in infected and treated animals. We conclude that FA-P407 coating of ART nanoparticles readily facilitates drug carriage and antiretroviral responses.

  10. miR-424 acts as a tumor radiosensitizer by targeting aprataxin in cervical cancer

    PubMed Central

    Jin, Hua; Zou, Hua; Xia, Wei; Dai, Nan; Dai, Xiao-Yan; Wang, Dong; Xu, Cheng-Xiong; Qing, Yi

    2016-01-01

    Previous studies have shown that some dysregulated miRNAs are involved in radioresistance of tumor cells. Here, we identified significantly decreased miR-424 expression in radioresistant cervical cancer cells and specimens from cervical cancer patients with radioresistance compared to their radiosensitive parental cells and specimens from radiosensitive patients, respectively. Ectopic expression of miR-424 significantly increased radiation-induced DNA damage, cell apoptosis and G2/M cell cycle arrest in radioresistant cervical cancer cells. Notably, miR-424 agomiR treatment can sensitize radioresistant cervical cancer cells to radiation in a xenograft model. Furthermore, we demonstrated that miR-424 regulated radiosensitivity by directly targeting aprataxin. Taken together, these findings suggest that miR-424 acts as a radiosensitizing miRNA and reveal a new therapeutic strategy for radioresistant cervical cancers. PMID:27769049

  11. Direct-acting Antivirals and Host-targeting Agents against the Hepatitis A Virus

    PubMed Central

    Kanda, Tatsuo; Nakamoto, Shingo; Wu, Shuang; Nakamura, Masato; Jiang, Xia; Haga, Yuki; Sasaki, Reina; Yokosuka, Osamu

    2015-01-01

    Hepatitis A virus (HAV) infection is a major cause of acute hepatitis and occasionally leads to acute liver failure in both developing and developed countries. Although effective vaccines for HAV are available, the development of new antivirals against HAV may be important for the control of HAV infection in developed countries where no universal vaccination program against HAV exists, such as Japan. There are two forms of antiviral agents against HAV: direct-acting antivirals (DAAs) and host-targeting agents (HTAs). Studies using small interfering ribonucleic acid (siRNA) have suggested that the HAV internal ribosomal entry site (IRES) is an attractive target for the control of HAV replication and infection. Among the HTAs, amantadine and interferon-lambda 1 (IL-29) inhibit HAV IRES-mediated translation and HAV replication. Janus kinase (JAK) inhibitors inhibit La protein expression, HAV IRES activity, and HAV replication. Based on this review, both DAAs and HTAs may be needed to control effectively HAV infection, and their use should continue to be explored. PMID:26623267

  12. Vitexicarpin Acts as a Novel Angiogenesis Inhibitor and Its Target Network

    PubMed Central

    Zhang, Bo; Liu, Lu; Zhao, Shiwen; Wang, Xu; Liu, Liyang; Li, Shao

    2013-01-01

    Vitexicarpin (VIT) isolated from the fruits of Vitex rotundifolia has shown antitumor, anti-inflammatory, and immunoregulatory properties. This work is designed to evaluate the antiangiogenic effects of VIT and address the underlying action mechanism of VIT by a network pharmacology approach. The results validated that VIT can act as a novel angiogenesis inhibitor. Firstly, VIT can exert good antiangiogenic effects by inhibiting vascular-endothelial-growth-factor- (VEGF-) induced endothelial cell proliferation, migration, and capillary-like tube formation on matrigel in a dose-dependent manner. Secondly, VIT was also shown to have an antiangiogenic mechanism through inhibition of cell cycle progression and induction of apoptosis. Thirdly, VIT inhibited chorioallantoic membrane angiogenesis as well as tumor angiogenesis in an allograft mouse tumor model. We further addressed VIT's molecular mechanism of antiangiogenic actions using one of our network pharmacology methods named drugCIPHER. Then, we tested some key molecules in the VEGF pathway targeted by VIT and verified the inhibition effects of VIT on AKT and SRC phosphorylation. Taken together, this work not only identifies VIT as a novel potent angiogenesis inhibitor, but also demonstrates that network pharmacology methods can be an effective and promising approach to make discovery and understand the action mechanism of herbal ingredients. PMID:23476684

  13. Targeting modular polyketide synthases with iteratively acting acyltransferases from metagenomes of uncultured bacterial consortia.

    PubMed

    Piel, Jörn; Hui, Dequan; Fusetani, Nobuhiro; Matsunaga, Shigeki

    2004-09-01

    Bacterial type I polyketide synthases (PKSs) produce a wide range of biomedically important secondary metabolites. These enzymes possess a modular structure that can be genetically re-engineered to yield novel drug candidates not found in nature. Recently, we have reported the putative pederin PKS from an uncultured bacterial symbiont of Paederus fuscipes beetles. It belongs to an architecturally unusual PKS group, the members of which contain iteratively acting acyltransferases that are not integrated into the PKS modules but are encoded by isolated genes. As these systems are rare, often contain additional unusual features and are of smaller size than regular PKSs, the development of a method for the targeted isolation of new group members would be of great interest. Here, we present a phylogenetic approach to identify these systems rapidly in highly complex metagenomic DNA samples. To demonstrate its practical value, we located two pederin-type PKS systems putatively involved in the biosynthesis of antitumour polyketides in the metagenomic DNA of beetles, sponges and their uncultivated bacterial symbionts.

  14. 50 CFR 622.496 - Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Annual catch limits (ACLs), annual catch.... Virgin Islands § 622.496 Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs). See § 622.12 for applicable ACLs and AMs....

  15. 50 CFR 622.457 - Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Annual catch limits (ACLs), annual catch.... Virgin Islands § 622.457 Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs). See § 622.12 for applicable ACLs and AMs....

  16. 50 CFR 622.439 - Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Annual catch limits (ACLs), annual catch.... Virgin Islands § 622.439 Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs). See § 622.12 for applicable ACLs and AMs....

  17. 50 CFR 622.439 - Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Annual catch limits (ACLs), annual catch.... Virgin Islands § 622.439 Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs). See § 622.12 for applicable ACLs and AMs....

  18. 50 CFR 622.193 - Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Annual catch limits (ACLs), annual catch... Region § 622.193 Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures... commercial ACLs, in round weight, are 284,680 lb (129,129 kg) for 2012, 315,920 lb (143,299 kg) for 2013,...

  19. 50 CFR 622.457 - Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Annual catch limits (ACLs), annual catch.... Virgin Islands § 622.457 Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs). See § 622.12 for applicable ACLs and AMs....

  20. 50 CFR 622.41 - Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Annual catch limits (ACLs), annual catch....41 Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs). (a... sector for the remainder of that fishing year. (3) The stock complex ACLs for Other SWG, in gutted...

  1. 50 CFR 622.496 - Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Annual catch limits (ACLs), annual catch.... Virgin Islands § 622.496 Annual catch limits (ACLs), annual catch targets (ACTs), and accountability measures (AMs). See § 622.12 for applicable ACLs and AMs....

  2. 50 CFR 648.101 - Summer flounder Annual Catch Target (ACT).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... uncertainty to recommend ACTs for the commercial and recreational fishing sectors as part of the summer... specific sources of management uncertainty that were considered, technical approaches to mitigating these sources of uncertainty, and any additional relevant information considered in the ACT...

  3. 50 CFR 648.141 - Black sea bass Annual Catch Target (ACT).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... uncertainty to recommend ACTs for the commercial and recreational fishing sectors as part of the black sea... specific sources of management uncertainty that were considered, technical approaches to mitigating these sources of uncertainty, and any additional relevant information considered in the ACT...

  4. 50 CFR 648.141 - Black sea bass Annual Catch Target (ACT).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... uncertainty to recommend ACTs for the commercial and recreational fishing sectors as part of the black sea... specific sources of management uncertainty that were considered, technical approaches to mitigating these sources of uncertainty, and any additional relevant information considered in the ACT...

  5. 50 CFR 648.101 - Summer flounder Annual Catch Target (ACT).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... uncertainty to recommend ACTs for the commercial and recreational fishing sectors as part of the summer... specific sources of management uncertainty that were considered, technical approaches to mitigating these sources of uncertainty, and any additional relevant information considered in the ACT...

  6. 50 CFR 648.101 - Summer flounder Annual Catch Target (ACT).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... uncertainty to recommend ACTs for the commercial and recreational fishing sectors as part of the summer... specific sources of management uncertainty that were considered, technical approaches to mitigating these sources of uncertainty, and any additional relevant information considered in the ACT...

  7. 50 CFR 648.141 - Black sea bass Annual Catch Target (ACT).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... uncertainty to recommend ACTs for the commercial and recreational fishing sectors as part of the black sea... specific sources of management uncertainty that were considered, technical approaches to mitigating these sources of uncertainty, and any additional relevant information considered in the ACT...

  8. Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of alpha1 glycine receptors.

    PubMed

    Crawford, Daniel K; Trudell, James R; Bertaccini, Edward J; Li, Kaixun; Davies, Daryl L; Alkana, Ronald L

    2007-09-01

    Considerable evidence indicates that ethanol acts on specific residues in the transmembrane domains of glycine receptors (GlyRs). In this study, we tested the hypothesis that the extracellular domain is also a target for ethanol action by investigating the effect of cysteine substitutions at positions 52 (extracellular domain) and 267 (transmembrane domain) on responses to n-alcohols and propyl methanethiosulfonate (PMTS) in alpha1GlyRs expressed in Xenopus oocytes. In support of the hypothesis: (i) The A52C mutation changed ethanol sensitivity compared to WT GlyRs; (ii) PMTS produced irreversible alcohol-like potentiation in A52C GlyRs; and (iii) PMTS binding reduced the n-chain alcohol cutoff in A52C GlyRs. Further studies used PMTS binding to cysteines at positions 52 or 267 to block ethanol action at one site in order to determine its effect at other site(s). In these situations, ethanol caused negative modulation when acting at position 52 and positive modulation when acting at position 267. Collectively, these findings parallel the evidence that established the TM domain as a target for ethanol, suggest that positions 52 and 267 are part of the same alcohol pocket and indicate that the net effect of ethanol on GlyR function reflects the summation of its positive and negative modulatory effects on different targets.

  9. 50 CFR 648.71 - Surfclam and ocean quahog Annual Catch Targets (ACT).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Surfclam and ocean quahog Annual Catch... Management Measures for the Atlantic Surf Clam and Ocean Quahog Fisheries § 648.71 Surfclam and ocean quahog... management uncertainty to recommend ACTs to the MAFMC as part of the surfclam and ocean quahog...

  10. 50 CFR 648.71 - Surfclam and ocean quahog Annual Catch Targets (ACT).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Surfclam and ocean quahog Annual Catch... Management Measures for the Atlantic Surf Clam and Ocean Quahog Fisheries § 648.71 Surfclam and ocean quahog... management uncertainty to recommend ACTs to the MAFMC as part of the surfclam and ocean quahog...

  11. 50 CFR 648.71 - Surfclam and ocean quahog Annual Catch Targets (ACT).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Surfclam and ocean quahog Annual Catch... Management Measures for the Atlantic Surf Clam and Ocean Quahog Fisheries § 648.71 Surfclam and ocean quahog... management uncertainty to recommend ACTs to the MAFMC as part of the surfclam and ocean quahog...

  12. MicroRNA 218 acts as a tumor suppressor by targeting multiple cancer phenotype-associated genes in medulloblastoma.

    PubMed

    Venkataraman, Sujatha; Birks, Diane K; Balakrishnan, Ilango; Alimova, Irina; Harris, Peter S; Patel, Purvi R; Handler, Michael H; Dubuc, Adrian; Taylor, Michael D; Foreman, Nicholas K; Vibhakar, Rajeev

    2013-01-18

    Aberrant expression of microRNAs has been implicated in many cancers. We recently demonstrated differential expression of several microRNAs in medulloblastoma. In this study, the regulation and function of microRNA 218 (miR-218), which is significantly underexpressed in medulloblastoma, was evaluated. Re-expression of miR-218 resulted in a significant decrease in medulloblastoma cell growth, cell colony formation, cell migration, invasion, and tumor sphere size. We used C17.2 neural stem cells as a model to show that increased miR-218 expression results in increased cell differentiation and also decreased malignant transformation when transfected with the oncogene REST. These results suggest that miR-218 acts as a tumor suppressor in medulloblastoma. MicroRNAs function by down-regulating translation of target mRNAs. Targets are determined by imperfect base pairing of the microRNA to the 3'-UTR of the mRNA. To comprehensively identify actual miR-218 targets, medulloblastoma cells overexpressing miR-218 and control cells were subjected to high throughput sequencing of RNA isolated by cross-linking immunoprecipitation, a technique that identifies the mRNAs bound to the RNA-induced silencing complex component protein Argonaute 2. High throughput sequencing of mRNAs identified 618 genes as targets of miR-218 and included both previously validated targets and many targets not predicted computationally. Additional work further confirmed CDK6, RICTOR, and CTSB (cathepsin B) as targets of miR-218 and examined the functional role of one of these targets, CDK6, in medulloblastoma.

  13. Acting Diverse: Target Group Orientation as Key Competence in Engineering Education

    ERIC Educational Resources Information Center

    Ihsen, S.; Buschmeyer, A.

    2007-01-01

    International companies are recognised by equity between men and women as well as between other different groups (Diversity) as an economic factor and incorporate it into their company visions. Mixed teams are set up to design target group-oriented products, for example in automotive engineering. Therefore they need employees who represent the…

  14. From adversary to target market: the ACT-UP boycott of Philip Morris

    PubMed Central

    Offen, N; Smith, E; Malone, R

    2003-01-01

    Background: In 1990, the AIDS Coalition to Unleash Power (ACT-UP) sparked a year long boycott of Philip Morris's Marlboro cigarettes and Miller beer. The boycott protested the company's support of Senator Jesse Helms (R-North Carolina), a leading opponent of AIDS funding and civil rights for lesbian, gay, bisexual and transgender (LGBT) people. ACT-UP demanded that Philip Morris sever its ties with Helms and acknowledge its responsibility to the LGBT community and to people with AIDS. Objective: To assess the impact of the boycott on the LGBT community, the tobacco industry, and the tobacco control movement; and to determine what lessons tobacco control advocates can extract from this case. Data sources: Internal tobacco industry documents and newspaper archives. Methods: Search of tobacco industry documents websites using "boycott", "ACT-UP", "gay", and other terms. Results: Philip Morris used the boycott to its own advantage. It exploited differences within the community and settled the boycott by pledging large donations to combat AIDS. Through corporate philanthropy, Philip Morris gained entrée to the LGBT market without appearing gay friendly. Many LGBT organisations, thirsty for recognition and funding from mainstream corporations, welcomed Philip Morris's overtures without considering the health hazards of tobacco. Conclusions: Unless the goal of a boycott is to convince the tobacco industry to abandon tobacco altogether, such actions invite the industry to expand its marketing under the guise of philanthropy. Tobacco control advocates should be clear about goals and acceptable settlement terms before participating in a boycott of a tobacco company. PMID:12773732

  15. Web entity extraction based on entity attribute classification

    NASA Astrophysics Data System (ADS)

    Li, Chuan-Xi; Chen, Peng; Wang, Ru-Jing; Su, Ya-Ru

    2011-12-01

    The large amount of entity data are continuously published on web pages. Extracting these entities automatically for further application is very significant. Rule-based entity extraction method yields promising result, however, it is labor-intensive and hard to be scalable. The paper proposes a web entity extraction method based on entity attribute classification, which can avoid manual annotation of samples. First, web pages are segmented into different blocks by algorithm Vision-based Page Segmentation (VIPS), and a binary classifier LibSVM is trained to retrieve the candidate blocks which contain the entity contents. Second, the candidate blocks are partitioned into candidate items, and the classifiers using LibSVM are performed for the attributes annotation of the items and then the annotation results are aggregated into an entity. Results show that the proposed method performs well to extract agricultural supply and demand entities from web pages.

  16. Entity Modeling and Immersive Decision Environments

    DTIC Science & Technology

    2011-09-01

    XCITE lifeform entities to detect and track moving or stationary objects is research and development work that should continue. The WRSTP team has... target identification scenario. A system dynamics model was developed to predict those results. Research limitations/Implications – While decision delays... target identification scenario. Many other decision models lack this time component and are therefore of limited use in time-critical situations. Take

  17. Transportin acts to regulate mitotic assembly events by target binding rather than Ran sequestration

    PubMed Central

    Bernis, Cyril; Swift-Taylor, Beth; Nord, Matthew; Carmona, Sarah; Chook, Yuh Min; Forbes, Douglass J.

    2014-01-01

    The nuclear import receptors importin β and transportin play a different role in mitosis: both act phenotypically as spatial regulators to ensure that mitotic spindle, nuclear membrane, and nuclear pore assembly occur exclusively around chromatin. Importin β is known to act by repressing assembly factors in regions distant from chromatin, whereas RanGTP produced on chromatin frees factors from importin β for localized assembly. The mechanism of transportin regulation was unknown. Diametrically opposed models for transportin action are as follows: 1) indirect action by RanGTP sequestration, thus down-regulating release of assembly factors from importin β, and 2) direct action by transportin binding and inhibiting assembly factors. Experiments in Xenopus assembly extracts with M9M, a superaffinity nuclear localization sequence that displaces cargoes bound by transportin, or TLB, a mutant transportin that can bind cargo and RanGTP simultaneously, support direct inhibition. Consistently, simple addition of M9M to mitotic cytosol induces microtubule aster assembly. ELYS and the nucleoporin 107–160 complex, components of mitotic kinetochores and nuclear pores, are blocked from binding to kinetochores in vitro by transportin, a block reversible by M9M. In vivo, 30% of M9M-transfected cells have spindle/cytokinesis defects. We conclude that the cell contains importin β and transportin “global positioning system”or “GPS” pathways that are mechanistically parallel. PMID:24478460

  18. Transportin acts to regulate mitotic assembly events by target binding rather than Ran sequestration.

    PubMed

    Bernis, Cyril; Swift-Taylor, Beth; Nord, Matthew; Carmona, Sarah; Chook, Yuh Min; Forbes, Douglass J

    2014-04-01

    The nuclear import receptors importin β and transportin play a different role in mitosis: both act phenotypically as spatial regulators to ensure that mitotic spindle, nuclear membrane, and nuclear pore assembly occur exclusively around chromatin. Importin β is known to act by repressing assembly factors in regions distant from chromatin, whereas RanGTP produced on chromatin frees factors from importin β for localized assembly. The mechanism of transportin regulation was unknown. Diametrically opposed models for transportin action are as follows: 1) indirect action by RanGTP sequestration, thus down-regulating release of assembly factors from importin β, and 2) direct action by transportin binding and inhibiting assembly factors. Experiments in Xenopus assembly extracts with M9M, a superaffinity nuclear localization sequence that displaces cargoes bound by transportin, or TLB, a mutant transportin that can bind cargo and RanGTP simultaneously, support direct inhibition. Consistently, simple addition of M9M to mitotic cytosol induces microtubule aster assembly. ELYS and the nucleoporin 107-160 complex, components of mitotic kinetochores and nuclear pores, are blocked from binding to kinetochores in vitro by transportin, a block reversible by M9M. In vivo, 30% of M9M-transfected cells have spindle/cytokinesis defects. We conclude that the cell contains importin β and transportin "global positioning system"or "GPS" pathways that are mechanistically parallel.

  19. RNA editing in plant mitochondria—connecting RNA target sequences and acting proteins.

    PubMed

    Takenaka, Mizuki; Verbitskiy, Daniil; Zehrmann, Anja; Härtel, Barbara; Bayer-Császár, Eszter; Glass, Franziska; Brennicke, Axel

    2014-11-01

    RNA editing changes several hundred cytidines to uridines in the mRNAs of mitochondria in flowering plants. The target cytidines are identified by a subtype of PPR proteins characterized by tandem modules which each binds with a specific upstream nucleotide. Recent progress in correlating repeat structures with nucleotide identities allows to predict and identify target sites in mitochondrial RNAs. Additional proteins have been found to play a role in RNA editing; their precise function still needs to be elucidated. The enzymatic activity performing the C to U reaction may reside in the C-terminal DYW extensions of the PPR proteins; however, this still needs to be proven. Here we update recent progress in understanding RNA editing in flowering plant mitochondria.

  20. Protein lysine methyltransferase G9a acts on non-histone targets

    PubMed Central

    Rathert, Philipp; Dhayalan, Arunkumar; Murakami, Marie; Zhang, Xing; Tamas, Raluca; Jurkowska, Renata; Komatsu, Yasuhiko; Shinkai, Yoichi; Cheng, Xiaodong; Jeltsch, Albert

    2009-01-01

    By methylation of peptide arrays, we determined the specificity profile of the protein methyltransferase G9a. We show that it mostly recognizes an Arg-Lys sequence and that its activity is inhibited by methylation of the arginine residue. Using the specificity profile, we identified new non-histone protein targets of G9a, including CDYL1, WIZ, ACINUS and G9a (automethylation), as well as peptides derived from CSB. We demonstrate potential downstream signaling pathways for methylation of non-histone proteins. PMID:18438403

  1. miR-508-5p acts as an anti-oncogene by targeting MESDC1 in hepatocellular carcinoma.

    PubMed

    Wu, S G; Huang, Y J; Bao, B; Wu, L M; Dong, J; Liu, X H; Li, Z H; Wang, X Y; Wang, L; Chen, B J; Chen, W

    2017-01-01

    Hepatocellular carcinoma (HCC) is the third leading cause of cancer associated mortality. Accumulating evidence has shown that microRNAs (miRNAs) act as critical factors for tumor recurrence and metastasis. MiR-508-5p has been reported as a down-regulated miRNA in the primary gastric cancer tissues. However, the role of miR-508-5p on HCC has not been well elucidated. In this study, we observed that miR-508-5p was downregulated in HCC tissues when compared to the non-tumorous tissues. We then demonstrated that overexpression of miR-508-5p attenuated HepG2 cells proliferation and invasion and induced cell apoptosis in vitro. Furthermore, our further investigations revealed that mesoderm development candidate 1 (MESDC1) is a potential target of miR-508-5p, as well as miR-508-5p overexpression downregulated MESDC1 expression. Overexpression of MESDC1 promoted HepG2 cells migration, invasion and proliferation in vitro. In addition, miR-508-5p markedly suppressed the tumor growth in xenograft model, while MESDC1 promoted the tumor growth in xenograft model. This study provides new insight into molecular mechanisms that miR-508-5p acts as a tumor suppressor by targeting MESDC1 in HCC progression.

  2. MicroRNA-98 acts as a tumor suppressor in hepatocellular carcinoma via targeting SALL4

    PubMed Central

    Zhou, Wuyuan; Zou, Benkui; Liu, Lisheng; Cui, Kai; Gao, Jie; Yuan, Shuanghu; Cong, Ning

    2016-01-01

    MicroRNAs (miRs) are involved in the development and progression of hepatocellular carcinoma (HCC), but the regulatory mechanism of miR-98 in HCC still remains unclear. Here we found that miR-98 was significantly downregulated in HCC tissues compared to matched adjacent normal tissues (ANTs). Low miR-98 expression was associated with tumor size, metastasis, portal vein tumor embolus, and poor overall survival. Ectopic expression of miR-98 decreased the proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of HCC cells. SALL4 was identified as a novel target of miR-98, and the protein expression of SALL4 was inhibited by miR-98 in HCC cells. Overexpression of SALL4 reversed the suppressive effects of miR-98 on the malignant phenotypes of HCC cells. Besides, SALL4, upregulated in HCC tissues compared to the matched ANTs, was inversely correlated to the miR-98 levels in HCC tissues. In addition, overexpression of miR-98 markedly suppressed the tumor growth as well as tumor-induced death in nude mice. In summary, miR-98 plays a suppressive role in the proliferation, migration, invasion and EMT of HCC cells, partly at least, via directly inhibition of SALL4. Therefore, the miR-98/SALL4 axis may become a promising therapeutic target for HCC. PMID:27677076

  3. Special Appropriation Act Projects

    EPA Pesticide Factsheets

    EPA is sometimes directed to provide funding to a specific entity for study, purpose, or activity.This information will be of interest to a community or other entity that has been identified in one of EPA's appropriations acts to receive such funding.

  4. 77 FR 75019 - Changes To Implement Micro Entity Status for Paying Patent Fees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... Patent and Trademark Office 37 CFR Part 1 RIN 0651-AC78 Changes To Implement Micro Entity Status for... patent cases to implement the micro entity provision of the Leahy-Smith America Invents Act (AIA...-five percent for micro entities. The Office is ] revising the rules of practice to set out...

  5. 76 FR 67384 - Extending Religious and Family Member FICA and FUTA Exceptions To Disregard Entities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-01

    ... Business entities; definitions. * * * * * (c) * * * (2) * * * (iv) * * * (A) [The text of the proposed... and FUTA Exceptions To Disregard Entities AGENCY: Internal Revenue Service (IRS), Treasury. ACTION... Unemployment Tax Act (``FUTA'') under sections 3121(b)(3), 3127, and 3306(c)(5) to entities that...

  6. Prorenin receptor acts as a potential molecular target for pancreatic ductal adenocarcinoma diagnosis.

    PubMed

    Arundhathi, Arivajiagane; Chuang, Wen-Han; Chen, Jen-Kun; Wang, Shin-E; Shyr, Yi-Ming; Chen, Jiun-Yu; Liao, Wei-Neng; Chen, Hsin-Wei; Teng, Yi-Min; Pai, Chiao-Chih; Wang, Chih-Hong

    2016-07-13

    Recent studies have implicated the prorenin receptor (PRR) is associated with pancreatic tumorigenesis. We therefore investigated the role of PRR in pancreatic tumorigenesis and assessed whether PRR can serve as a target for imaging diagnosis at early stages of PDAC. Here we show that aberrant expression of PRR in premalignant PanIN lesions, and human PDAC samples, and PDAC cell lines, particularly in Panc-1 cells. Interestingly, PRR expression was positively associated with PDAC progression. Moreover, overexpression of human PRR resulted in increased cell proliferation and decreased apoptosis, while knockdown of human PRR caused decreased cell proliferation and enhanced apoptosis in pancreatic cancer cells. We also observed that overexpression of human PRR enhanced MAPK and PI3K/Akt signaling pathways in PDAC cells, while knockdown of human PRR suppressed both of pathways. The confocal imaging analysis showed that human PRR was highly expressed in Panc-1, ASPC, and Miapaca cells, whereas BXPC-3, and HPAC cells had a significantly lower fluorescent signals. Consistently, the single-photon emission computed tomography (SPET/CT) showed that the uptake of anti-PRR labelled with 125I was higher in Panc-1 and ASPC tumors-bearing mice after 96 hours injection. Importantly, tumors in pancreas of Pdx1-cre; LSL-KrasG12D mice had a significant increased PRR expression and accumulation of radioactivity at 96 h after injection. These data suggest that 125I-anti-PRR can detect the orthotopic tumors in Pdx1-cre; LSL-KrasG12D mice. Therefore, anti-PRR labelled with 125I is a promising radiotracer for imaging diagnosis at early stages of pancreatic cancer.

  7. Prorenin receptor acts as a potential molecular target for pancreatic ductal adenocarcinoma diagnosis

    PubMed Central

    Shyr, Yi-Ming; Chen, Jiun-Yu; Liao, Wei-Neng; Chen, Hsin-Wei; Teng, Yi-Min; Pai, Chiao-Chih; Wang, Chih-Hong

    2016-01-01

    Recent studies have implicated the prorenin receptor (PRR) is associated with pancreatic tumorigenesis. We therefore investigated the role of PRR in pancreatic tumorigenesis and assessed whether PRR can serve as a target for imaging diagnosis at early stages of PDAC. Here we show that aberrant expression of PRR in premalignant PanIN lesions, and human PDAC samples, and PDAC cell lines, particularly in Panc-1 cells. Interestingly, PRR expression was positively associated with PDAC progression. Moreover, overexpression of human PRR resulted in increased cell proliferation and decreased apoptosis, while knockdown of human PRR caused decreased cell proliferation and enhanced apoptosis in pancreatic cancer cells. We also observed that overexpression of human PRR enhanced MAPK and PI3K/Akt signaling pathways in PDAC cells, while knockdown of human PRR suppressed both of pathways. The confocal imaging analysis showed that human PRR was highly expressed in Panc-1, ASPC, and Miapaca cells, whereas BXPC-3, and HPAC cells had a significantly lower fluorescent signals. Consistently, the single-photon emission computed tomography (SPET/CT) showed that the uptake of anti-PRR labelled with 125I was higher in Panc-1 and ASPC tumors-bearing mice after 96 hours injection. Importantly, tumors in pancreas of Pdx1-cre; LSL-KrasG12D mice had a significant increased PRR expression and accumulation of radioactivity at 96 h after injection. These data suggest that 125I-anti-PRR can detect the orthotopic tumors in Pdx1-cre; LSL-KrasG12D mice. Therefore, anti-PRR labelled with 125I is a promising radiotracer for imaging diagnosis at early stages of pancreatic cancer. PMID:27419631

  8. Thyroid hormone synthesis: a potential target of a Chinese herbal formula Haizao Yuhu Decoction acting on iodine-deficient goiter

    PubMed Central

    Mao, Xia; Yan, Chen; Guo, Xiaodong; Guo, Qiuyan; Liu, Zhenli; Song, Zhiqian; Lin, Na

    2016-01-01

    Haizao Yuhu Decoction (HYD), a famous multi-component herbal formula, has been widely used to treat various thyroid-related diseases, including iodine-deficient goiter. Herb pair Thallus Sargassi Pallidi (HZ) and Radix Glycyrrhizae (GC), one of the so-called “eighteen antagonistic medicaments”, contains in HYD. To explore pharmacological mechanisms of HYD acting on iodine-deficient goiter and to provide evidence for potential roles of herb pair HZ and GC in HYD, our genome-wide microarray detection and network analysis identified a list of goiter-related genes, mainly involved into the alterations in hypothalamus-pituitary-thyroid/gonad/growth axes. Then, the disease genes-drug genes interaction network illustrated the links between HYD regulating genes and goiter-related genes, and identified the candidate targets of HYD acting on goiter. Functionally, these candidate targets were closely correlated with thyroid hormone synthesis. Moreover, the potential regulating genes of herb pair HZ and GC were revealed to be crucial components in the pathway of thyroid hormone synthesis. The prediction results were all verified by following experiments based on goiter rats. Collectively, this integrative study combining microarray gene expression profiling, network analysis and experimental validations offers the convincing evidence that HYD may alleviate iodine-deficient goiter via regulating thyroid hormone synthesis, and explains the necessity of herb pair HZ and GC in HYD. Our work provides a novel and powerful means to clarify the mechanisms of action for multi-component drugs such as herbal formulae in a holistic way, which may improve drug development and applications. PMID:27384475

  9. 76 FR 44776 - Provisions Common to Registered Entities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    ... Provisions Common to Registered Entities AGENCY: Commodity Futures Trading Commission. ACTION: Final Rule... certain statutory provisions of the Dodd-Frank Wall Street Reform and Consumer Protection Act (``Dodd... certain statutory provisions of the Dodd-Frank Act and to amend existing regulations governing...

  10. miR-34c-3p acts as a tumor suppressor gene in osteosarcoma by targeting MARCKS

    PubMed Central

    Liu, Hongliang; Su, Pengxiao; Zhi, Liqiang; Zhao, Kai

    2017-01-01

    Previous studies have demonstrated that microRNA (miR)-34c-3p is important in human cancer progression. However, the function of miR-34c-3p in osteosarcoma (OS) remains to be elucidated. In the present study, miR-34c-3p level was measured by reverse transcription-quantitative polymerase chain reaction in OS tissues and the associated prognostic value for overall survival was determined. The function of miR-34c-3p was examined in vitro and in vivo. A luciferase reporter assay was used to identify the targets of miR-34c-3p. The results of the present study revealed that miR-34c-3p was downregulated in OS tissues and cell lines, and decreased levels of miR-34c-3p were associated with a high mortality rate in patients with OS. Furthermore, restoration of miR-34c-3p expression reduced cell growth in vitro and suppressed tumorigenesis in vivo. Conversely, inhibition of miR-34c-3p stimulated OS cell growth in vitro and in vivo. Myristoylated alanine-rich protein kinase C substrate (MARCKS) was identified as a direct target of miR-34c-3p and its overexpression partly reversed the suppressive effects of miR-34c-3p. Furthermore, MARCKS was revealed to be upregulated and inversely correlated with miR-34c-3p levels in OS tissues. These data suggested that miR-34c-3p acts as a tumor suppressor via regulation of MARCKS expression in OS progression and miR-34c-3p may be a promising therapeutic target for this type of cancer. PMID:28075441

  11. Grainyhead-like 2 downstream targets act to suppress epithelial-to-mesenchymal transition during neural tube closure.

    PubMed

    Ray, Heather J; Niswander, Lee A

    2016-04-01

    The transcription factor grainyhead-like 2 (GRHL2) is expressed in non-neural ectoderm (NNE) and Grhl2 loss results in fully penetrant cranial neural tube defects (NTDs) in mice. GRHL2 activates expression of several epithelial genes; however, additional molecular targets and functional processes regulated by GRHL2 in the NNE remain to be determined, as well as the underlying cause of the NTDs in Grhl2 mutants. Here, we find that Grhl2 loss results in abnormal mesenchymal phenotypes in the NNE, including aberrant vimentin expression and increased cellular dynamics that affects the NNE and neural crest cells. The resulting loss of NNE integrity contributes to an inability of the cranial neural folds to move toward the midline and results in NTD. Further, we identified Esrp1, Sostdc1, Fermt1, Tmprss2 and Lamc2 as novel NNE-expressed genes that are downregulated in Grhl2 mutants. Our in vitro assays show that they act as suppressors of the epithelial-to-mesenchymal transition (EMT). Thus, GRHL2 promotes the epithelial nature of the NNE during the dynamic events of neural tube formation by both activating key epithelial genes and actively suppressing EMT through novel downstream EMT suppressors.

  12. Learning plan applicability through active mental entities

    SciTech Connect

    Baroni, Pietro; Fogli, Daniela; Guida, Giovanni

    1999-03-22

    This paper aims at laying down the foundations of a new approach to learning in autonomous mobile robots. It is based on the assumption that robots can be provided with built-in action plans and with mechanisms to modify and improve such plans. This requires that robots are equipped with some form of high-level reasoning capabilities. Therefore, the proposed learning technique is embedded in a novel distributed control architecture featuring an explicit model of robot's cognitive activity. In particular, cognitive activity is obtained by the interaction of active mental entities, such as intentions, persuasions and expectations. Learning capabilities are implemented starting from the interaction of such mental entities. The proposal is illustrated through an example concerning a robot in charge of reaching a target in an unknown environment cluttered with obstacles.

  13. State and Local Implementation of the No Child Left Behind Act. Volume VI--Targeting and Uses of Federal Education Funds

    ERIC Educational Resources Information Center

    Chambers, Jay G.; Lam, Irene; Mahitivanichcha, Kanya; Esra, Phil; Shambaugh, Larisa; Stullich, Stephanie

    2009-01-01

    Achieving the goals of federal education legislation depends on how federal funds are distributed and used. Since the enactment of the Elementary and Secondary Education Act (ESEA) in 1965, various federal programs have been created to support educational improvement and target additional resources to meet the educational needs of children who are…

  14. 22 CFR 96.5 - Requirement that accrediting entity be a nonprofit or public entity.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... nonprofit or public entity. An accrediting entity must qualify as either: (a) An organization described in... administering standards for entities providing child welfare services; or (b) A public entity (other than a... child welfare services....

  15. "New drug" designations for new therapeutic entities: new active substance, new chemical entity, new biological entity, new molecular entity.

    PubMed

    Branch, Sarah K; Agranat, Israel

    2014-11-13

    This Perspective addresses ambiguities in designations of "new drugs" intended as new therapeutic entities (NTEs). Designation of an NTE as a new drug is significant, as it may confer regulatory exclusivity, an important incentive for development of novel compounds. Such designations differ between jurisdictions according to their drug laws and drug regulations. Chemical, biological, and innovative drugs are addressed in turn. The terms new chemical entity (NCE), new molecular entity (NME), new active substance (NAS), and new biological entity (NBE) as applied in worldwide jurisdictions are clarified. Differences between them are explored through case studies showing why new drugs have different periods of exclusivity in different jurisdictions or none at all. Finally, this Perspective recommends that in future, for the purpose of new drug compilations, NME is used for a new chemical drug, NBE for a new biological drug, and the combined designation NTE should refer to either an NME or an NBE.

  16. 17 CFR 229.1107 - (Item 1107) Issuing entities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed Securities (Regulation AB) § 229...(a)(2) of this Regulation AB, depositor, issuing entity, originator contemplated by Item 1110 of this Regulation AB, underwriter, or any affiliate of the foregoing, separately identify the type and amount...

  17. 17 CFR 229.1107 - (Item 1107) Issuing entities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed Securities (Regulation AB) § 229...(a)(2) of this Regulation AB, depositor, issuing entity, originator contemplated by Item 1110 of this Regulation AB, underwriter, or any affiliate of the foregoing, separately identify the type and amount...

  18. 17 CFR 229.1107 - (Item 1107) Issuing entities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed Securities (Regulation AB) § 229...(a)(2) of this Regulation AB, depositor, issuing entity, originator contemplated by Item 1110 of this Regulation AB, underwriter, or any affiliate of the foregoing, separately identify the type and amount...

  19. 17 CFR 229.1107 - (Item 1107) Issuing entities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed Securities (Regulation AB) § 229...(a)(2) of this Regulation AB, depositor, issuing entity, originator contemplated by Item 1110 of this Regulation AB, underwriter, or any affiliate of the foregoing, separately identify the type and amount...

  20. 17 CFR 229.1107 - (Item 1107) Issuing entities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed Securities (Regulation AB) § 229...(a)(2) of this Regulation AB, depositor, issuing entity, originator contemplated by Item 1110 of this Regulation AB, underwriter, or any affiliate of the foregoing, separately identify the type and amount...

  1. 16 CFR 801.50 - Formation of unincorporated entities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Formation of unincorporated entities. 801.50 Section 801.50 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 COVERAGE RULES § 801.50...

  2. 16 CFR 801.50 - Formation of unincorporated entities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Formation of unincorporated entities. 801.50 Section 801.50 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 COVERAGE RULES § 801.50...

  3. 16 CFR 801.50 - Formation of unincorporated entities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Formation of unincorporated entities. 801.50 Section 801.50 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 COVERAGE RULES § 801.50...

  4. 16 CFR 801.50 - Formation of unincorporated entities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Formation of unincorporated entities. 801.50 Section 801.50 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 COVERAGE RULES § 801.50...

  5. 16 CFR 801.50 - Formation of unincorporated entities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Formation of unincorporated entities. 801.50 Section 801.50 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 COVERAGE RULES § 801.50...

  6. 18 CFR 39.8 - Delegation to a Regional Entity.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Delegation to a Regional Entity. 39.8 Section 39.8 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT RULES CONCERNING CERTIFICATION...

  7. Beyond new chemical entities

    PubMed Central

    Caoili, Salvador Eugenio C; Caoili, Salvador Eugenio C

    2014-01-01

    Antibody-type agents (i.e., antibodies and derivatives thereof) may be produced as clinically valuable antidotes, which conceivably could be developed in tandem with prospective new pharmaceutical products so as to render the risks of clinical trials more acceptable from a regulatory standpoint. Yet, this is but a relatively narrow view of the full potential utility associated with antibody-type agents, the significance of which is appreciated upon reconsidering key aspects of early modern biomedical research (notably major contributions thereto by Nobel Laureate Paul Ehrlich) in light of much more recent advances (e.g., application of immunity-oriented approaches to diseases in general, epitope-specific targeting, abzyme-mediated catalysis, antibody-mediated sustained-release buffering of unbound-ligand concentrations, and enhanced thermal and metabolic stability of deuterated chemical species via the kinetic isotope effect), as conditioned by health-related concerns (e.g., current and anticipated epidemiologic transitions vis-a-vis environmental changes) especially with regard to sustainable development (e.g., emphasizing more efficient resource utilization toward increased global resilience based on greater independence from high-maintenance technological infrastructure). The broader view that thus emerges highlights the urgent need to rebalance the health-research agenda, which presently reflect an overemphasis on small-molecule candidate-drug discovery, in order to advance health based on a comprehensive fundamental synthesis of immunity and pharmacology. PMID:24632567

  8. 22 CFR 709.4 - Cause for suspension of entities from eligibility.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Cause for suspension of entities from eligibility. 709.4 Section 709.4 Foreign Relations OVERSEAS PRIVATE INVESTMENT CORPORATION ADMINISTRATIVE PROVISIONS FOREIGN CORRUPT PRACTICES ACT OF 1977 § 709.4 Cause for suspension of entities from...

  9. 22 CFR 709.4 - Cause for suspension of entities from eligibility.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Cause for suspension of entities from eligibility. 709.4 Section 709.4 Foreign Relations OVERSEAS PRIVATE INVESTMENT CORPORATION ADMINISTRATIVE PROVISIONS FOREIGN CORRUPT PRACTICES ACT OF 1977 § 709.4 Cause for suspension of entities from...

  10. 29 CFR 1635.6 - Causing a covered entity to discriminate.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 4 2011-07-01 2011-07-01 false Causing a covered entity to discriminate. 1635.6 Section 1635.6 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION GENETIC INFORMATION NONDISCRIMINATION ACT OF 2008 § 1635.6 Causing a covered entity to discriminate. A covered...

  11. 29 CFR 1635.6 - Causing a covered entity to discriminate.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 4 2012-07-01 2012-07-01 false Causing a covered entity to discriminate. 1635.6 Section 1635.6 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION GENETIC INFORMATION NONDISCRIMINATION ACT OF 2008 § 1635.6 Causing a covered entity to discriminate. A covered...

  12. 29 CFR 1635.6 - Causing a covered entity to discriminate.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 4 2014-07-01 2014-07-01 false Causing a covered entity to discriminate. 1635.6 Section 1635.6 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION GENETIC INFORMATION NONDISCRIMINATION ACT OF 2008 § 1635.6 Causing a covered entity to discriminate. A covered...

  13. 29 CFR 1635.6 - Causing a covered entity to discriminate.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 4 2013-07-01 2013-07-01 false Causing a covered entity to discriminate. 1635.6 Section 1635.6 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION GENETIC INFORMATION NONDISCRIMINATION ACT OF 2008 § 1635.6 Causing a covered entity to discriminate. A covered...

  14. 20 CFR 662.210 - What other entities may serve as One-Stop partners?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What other entities may serve as One-Stop... LABOR DESCRIPTION OF THE ONE-STOP SYSTEM UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT One-Stop Partners and the Responsibilities of Partners § 662.210 What other entities may serve as One-Stop partners?...

  15. 20 CFR 669.210 - How does an eligible entity become an NFJP grantee?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... LABOR NATIONAL FARMWORKER JOBS PROGRAM UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT The Service Delivery System for the National Farmworker Jobs Program § 669.210 How does an eligible entity become...

  16. 17 CFR 202.9 - Small entity enforcement penalty reduction policy.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... involved willful or criminal conduct; or (iii) The small entity did not make a good faith effort to comply... analysis of the language and legislative history of the Reg. Flex. Act, Congress does not appear to...

  17. 17 CFR 202.9 - Small entity enforcement penalty reduction policy.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Small entity enforcement penalty reduction policy. 202.9 Section 202.9 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... Investment Company Act of 1940, the Investment Advisers Act of 1940, the Securities Exchange Act of 1934,...

  18. Sterile pyuria: a forgotten entity

    PubMed Central

    Persad, Raj

    2015-01-01

    Sterile pyuria is a common entity. Yet there are no guidelines to address this issue. We have conducted a systematic review over 20 years and reviewed the results. Guidelines for assessment, diagnosis and management are developed based on these results. PMID:26425144

  19. Evaluating Stream Filtering for Entity Profile Updates for TREC 2013 (KBA Track Overview)

    DTIC Science & Technology

    2013-11-01

    language processing ( NLP ) and information retrieval (IR). Filtering tracks in TREC have typically used queries based on topics described by a set...documents and new slot fills that would change a target entity?s profile. This combines thinking from natural language processing ( NLP ) and information...structured properties of the entities gathered from knowledge bases, and can also leverage the extensive research in natural language processing ( NLP

  20. Brachioradial pruritus--an enigmatic entity.

    PubMed

    Barry, R; Rogers, S

    2004-11-01

    Brachioradial pruritus (BRP) is an unusual clinical entity resulting in pruritus of the upper arms, classically affecting the skin overlying the proximal heads of the brachioradialis muscles. Seven patients with BRP are described. The upper limb was involved in six patients, being bilateral in four and restricted to the right arm in two. Radiological evidence of cervical vertebral osteoarthritis was seen in five. Three patients reported exacerbation with ultraviolet radiation (UVR), i.e., sunlight. All seven were treated with topical capsaicin and four got significant relief. Two of the remaining three patients found relief from amitryptiline. UVR may act as a trigger in some patients although underlying neurological cervical injury also seems to be an important aetiological factor.

  1. Abnormal sperm in mice with targeted deletion of the act (activator of cAMP-responsive element modulator in testis) gene

    PubMed Central

    Kotaja, Noora; De Cesare, Dario; Macho, Betina; Monaco, Lucia; Brancorsini, Stefano; Goossens, Ellen; Tournaye, Herman; Gansmuller, Anne; Sassone-Corsi, Paolo

    2004-01-01

    ACT [activator of cAMP-responsive element modulator (CREM) in testis] is a LIM-only protein that interacts with transcription factor CREM in postmeiotic male germ cells and enhances CREM-dependent transcription. CREM regulates many crucial genes required for spermatid maturation, and targeted mutation of the Crem gene in the mouse germ-line blocks spermatogenesis. Here we report the phenotype of mice in which targeted disruption of the act gene was obtained by homologous recombination. Whereas the seminiferous tubules of the act–/– mice contain all of the developmental stages of germ cells and the mice are fertile, the amount of mature sperm in the epididymis is drastically reduced. The residual sperm display severe abnormalities, including fully folded tails and aberrant head shapes. These results indicate that numerous postmeiotic genes under CREM control require the coactivator function of ACT. Thus, the fine-tuning of sperm development is achieved by the coordinated action of two transcriptional regulators. PMID:15247423

  2. Localized Netrins Act as Positional Cues to Control Layer-Specific Targeting of Photoreceptor Axons in Drosophila

    PubMed Central

    Timofeev, Katarina; Joly, Willy; Hadjieconomou, Dafni; Salecker, Iris

    2012-01-01

    Summary A shared feature of many neural circuits is their organization into synaptic layers. However, the mechanisms that direct neurites to distinct layers remain poorly understood. We identified a central role for Netrins and their receptor Frazzled in mediating layer-specific axon targeting in the Drosophila visual system. Frazzled is expressed and cell autonomously required in R8 photoreceptors for directing their axons to the medulla-neuropil layer M3. Netrin-B is specifically localized in this layer owing to axonal release by lamina neurons L3 and capture by target neuron-associated Frazzled. Ligand expression in L3 is sufficient to rescue R8 axon-targeting defects of Netrin mutants. R8 axons target normally despite replacement of diffusible Netrin-B by membrane-tethered ligands. Finally, Netrin localization is instructive because expression in ectopic layers can retarget R8 axons. We propose that provision of localized chemoattractants by intermediate target neurons represents a highly precise strategy to direct axons to a positionally defined layer. PMID:22794263

  3. A T7exonuclease-assisted target recycling amplification with graphene oxide acting as the signal amplifier for fluorescence polarization detection of human immunodeficiency virus (HIV) DNA.

    PubMed

    Wang, Lijun; Tian, Jianniao; Yang, Wen; Zhao, Yanchun; Zhao, Shulin

    2016-03-01

    We report a fluorescence polarization (FP) platform for human immunodeficiency virus (HIV) DNA detection based on T7exonuclease-assisted target recycling amplification with graphene oxide (GO) acting as a FP signal amplifier. In the sensing method, the presence of the target DNA leads to target recycling with the assistance of T7exonuclease, furthermore, the amplification products are absorbed onto the surface of GO, so the all FP values are enhanced by GO. More importantly, this FP sensor exhibits high detection sensitivity; under optimal conditions, the change in FP is linear with the concentration of the target DNA within a concentration range of 50-2000 pmol/L, and the detection limit of this method is as low as 38.6 pmol/L. This FP sensor also exhibits high selectivity, even single-base mismatched DNA can be effectively discriminated from complementary target DNA. Above all, the proposed FP sensor may serve as a general platform for the sensitive assay of disease-related genes.

  4. Uncovering pharmacological mechanisms of Wu-tou decoction acting on rheumatoid arthritis through systems approaches: drug-target prediction, network analysis and experimental validation.

    PubMed

    Zhang, Yanqiong; Bai, Ming; Zhang, Bo; Liu, Chunfang; Guo, Qiuyan; Sun, Yanqun; Wang, Danhua; Wang, Chao; Jiang, Yini; Lin, Na; Li, Shao

    2015-03-30

    Wu-tou decoction (WTD) has been extensively used for the treatment of rheumatoid arthritis (RA). Due to lack of appropriate methods, pharmacological mechanisms of WTD acting on RA have not been fully elucidated. In this study, a list of putative targets for compositive compounds containing in WTD were predicted by drugCIPHER-CS. Then, the interaction network of the putative targets of WTD and known RA-related targets was constructed and hub nodes were identified. After constructing the interaction network of hubs, four topological features of each hub, including degree, node betweenness, closeness and k-coreness, were calculated and 79 major hubs were identified as candidate targets of WTD, which were implicated into the imbalance of the nervous, endocrine and immune (NEI) systems, leading to the main pathological changes during the RA progression. Further experimental validation also demonstrated the preventive effects of WTD on inflammation and joint destruction in collagen-induced arthritis (CIA) rats and its regulatory effects on candidate targets both in vitro and in vivo systems. In conclusion, we performed an integrative analysis to offer the convincing evidence that WTD may attenuate RA partially by restoring the balance of NEI system and subsequently reversing the pathological events during RA progression.

  5. Entity- Version 1.0

    SciTech Connect

    Hart, Brian; Oppel, Fred; Rigdon, Brian; Whitfor, Gregg; Summers, Kenneth; Jungels, John

    2012-09-13

    This package contains classes that capture high-level aspects of characters and vehicles. Vehicles manage seats and riders. Vehicles and characters now can be configured to compose different behaviors and have certain capabilities, by adding them through xml data. These behaviors and capabilities are not included in this package, but instead are part of other packages such as mobility behavior, path planning, sight, sound. Entity is not dependent on these other packages. This package also contains the icons used for Umbra applications Dante Scenario Editor, Dante Tabletop and OpShed. This assertion includes a managed C++ wrapper code (EntityWrapper) to enable C# applications, such as Dante Scenario Editor, Dante Tabletop, and OpShed, to incorporate this library.

  6. Compulsive buying: an overlooked entity.

    PubMed

    Basu, Bishnupriya; Basu, Saikat; Basu, Jharna

    2011-08-01

    Compulsive buying is an under-recognised entity among Indian psychiatrists. A Medline search, hand searching of journals and direct communications with lead investigators in compulsive buying have generated numerous studies. Overseas data indicate a community prevalence between 1% and 8% . The phenomenon can be an independent entity or appears as a comorbidity with another axis I or axis II disorder. A degree of suspicion on part of clinician regarding its possible presence is the key to its detection. A few rating instruments are available to quantify the morbidity and screening for compulsive buying. Management involves pharmacotherapy with SSRIs, psychotherapy, self-help groups and self-help books. Epidemiological and clinical studies on compulsive buying should be undertaken by Indian psychiatrists to provide better services for people suffering from compulsive buying.

  7. Collagenous colitis: an unrecognised entity.

    PubMed Central

    Bogomoletz, W V; Adnet, J J; Birembaut, P; Feydy, P; Dupont, P

    1980-01-01

    A patient is reported with chronic abdominal pain, diarrhoea, and associated radiological and endoscopic abnormalities of the sigmoid colon. Light and electron microscopic study of colorectal mucosa showed abnormal collagenous thickening of the subepithelial basement membrane. The authors felt that the clinical and morphological features justified a diagnosis of collagenous colitis. Review of the literature suggested that collagenous colitis was still an unrecognised entity. Images Fig. 1 Fig. 2 Fig. 3 PMID:7380341

  8. MiR-422a acts as a tumor suppressor in glioblastoma by targeting PIK3CA

    PubMed Central

    Liang, Haiqian; Wang, Renjie; Jin, Ying; Li, Jianwei; Zhang, Sai

    2016-01-01

    Although surgical treatment, chemotherapy, and radiotherapy have improved the overall survival rate in glioblastoma multiforme (GBM), further intensive research of GBM’s molecular mechanism is still needed. In this study, we observed that miR-422a was downregulated in GBM tissues and cell lines by quantitative real-time polymerase chain reaction (PCR) and primer extension assay. Overexpression of miR-422a significantly reduced the cell proliferation, migration, and invasion of GBM cells. Functional study indicated that miR-422a inhibited cell proliferation, invasion, and migration by targeting PIK3CA, an important member of PI3K/Akt signal pathway. These results demonstrate that the miR-422a/PIK3CA axis may constitute a potential target for GBM therapy. PMID:27648359

  9. miR-574-3p acts as a tumor promoter in osteosarcoma by targeting SMAD4 signaling pathway

    PubMed Central

    Xu, Haidong; Liu, Xiaozhou; Zhou, Juan; Chen, Xiaoyun; Zhao, Jianning

    2016-01-01

    Human osteosarcoma is the most common primary bone malignancy sarcoma that affects primarily children and people <20 years old. In the present study, it was demonstrated that miR-574-3p was downregulated in human osteosarcoma U2OS, SAOS and MG63 cells lines as well as in osteosarcoma tissue compared with the normal tissues. Downregulation of miR-574-3p by antisense miR-574-3p, inhibited cell growth and induced cell apoptosis. Overexpression of miR-574-3p by transfection with miR-574-3p mimics promoted the growth of U2OS cells. The present study then identified mothers against decapentaplegic homolog 4 (SMAD4) as a target of miR-574-3p and SMAD4 was suppressed in miR-574-3p transfected cells. Overexpression of SMAD4 could rescue the promoting effects of miR-574-3p on cancer cell growth. In conclusion, miR-574-3p exerts tumor-promoting roles by targeting the tumor-suppressing gene SMAD4 and its downstream signaling in human osteosarcoma, which provides a novel target for the treatment. PMID:28105233

  10. miRNA-101 acts as a tumor suppressor in oral squamous cell carcinoma by targeting CX chemokine receptor 7

    PubMed Central

    Hui, Yuan; Li, Yu; Jing, Yan; Feng, Jian-Q; Ding, Yin

    2016-01-01

    miR-101 is significantly downregulated in various human cancers, including oral squamous cell carcinoma (OSCC). However, the role of miR-101 in OSCC has not been elucidated. In this study, miR-101 lowly expressed in OSCC tissues and cell lines compared with that in adjacent normal tissues and human normal oral keratinocyte cells. Bioinformatics analysis predicted that miR-101 could potentially target CX chemokine receptor 7 (CXCR7), a promoter of tumor development, to attenuate OSCC progression. Restoring miR-101 expression in OSCC cells suppressed cell proliferation, invasion, and migration. The ectopic expression of CXCR7 in OSCC cells overexpressing miR-101 restored the proliferation and motility capabilities abolished by miR-101. The inhibitory effects of miR-101 on OSCC growth and metastasis were mimicked by CXCR7 knockdown in vivo. CXCR7 expression was upregulated in OSCC tissues. The high expression level of CXCR7 was negatively correlated with miR-101 level and poor prognosis of patients with OSCC. Overall, miR-101 exerts tumor-suppressive functions by targeting CXCR7, leading to inhibition of OSCC cell growth, invasion, and migration. Hence, miR-101 may be a potential target for OSCC diagnosis and therapeutic applications. PMID:27904690

  11. 2 CFR 170.310 - Entity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Entity. 170.310 Section 170.310 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET... INFORMATION Definitions § 170.310 Entity. Entity has the meaning given in 2 CFR part 25....

  12. 2 CFR 170.310 - Entity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Entity. 170.310 Section 170.310 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET... COMPENSATION INFORMATION Definitions § 170.310 Entity. Entity has the meaning given in 2 CFR part 25....

  13. 2 CFR 170.310 - Entity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Entity. 170.310 Section 170.310 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET... COMPENSATION INFORMATION Definitions § 170.310 Entity. Entity has the meaning given in 2 CFR part 25....

  14. 14 CFR 1-6 - Accounting entities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Accounting entities. Sec. 1-6 Section Sec... General Accounting Provisions Sec. 1-6 Accounting entities. (a) Separate accounting records shall be... forth above. (c) The records for each required accounting entity shall be maintained with...

  15. 2 CFR 170.310 - Entity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Entity. 170.310 Section 170.310 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET... Definitions § 170.310 Entity. Entity has the meaning given in 2 CFR part 25....

  16. 77 FR 56571 - Unincorporated Business Entities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-13

    ..., 621, 622, 623, and 630 RIN 3052-AC65 Unincorporated Business Entities AGENCY: Farm Credit... business entities (UBEs) organized under State law for certain business activities. For purposes of this... business entities, such as unincorporated business trusts, organized under State law. This rule does...

  17. Determining similarity of scientific entities in annotation datasets.

    PubMed

    Palma, Guillermo; Vidal, Maria-Esther; Haag, Eric; Raschid, Louiqa; Thor, Andreas

    2015-01-01

    Linked Open Data initiatives have made available a diversity of scientific collections where scientists have annotated entities in the datasets with controlled vocabulary terms from ontologies. Annotations encode scientific knowledge, which is captured in annotation datasets. Determining relatedness between annotated entities becomes a building block for pattern mining, e.g. identifying drug-drug relationships may depend on the similarity of the targets that interact with each drug. A diversity of similarity measures has been proposed in the literature to compute relatedness between a pair of entities. Each measure exploits some knowledge including the name, function, relationships with other entities, taxonomic neighborhood and semantic knowledge. We propose a novel general-purpose annotation similarity measure called 'AnnSim' that measures the relatedness between two entities based on the similarity of their annotations. We model AnnSim as a 1-1 maximum weight bipartite match and exploit properties of existing solvers to provide an efficient solution. We empirically study the performance of AnnSim on real-world datasets of drugs and disease associations from clinical trials and relationships between drugs and (genomic) targets. Using baselines that include a variety of measures, we identify where AnnSim can provide a deeper understanding of the semantics underlying the relatedness of a pair of entities or where it could lead to predicting new links or identifying potential novel patterns. Although AnnSim does not exploit knowledge or properties of a particular domain, its performance compares well with a variety of state-of-the-art domain-specific measures. Database URL: http://www.yeastgenome.org/

  18. Determining similarity of scientific entities in annotation datasets

    PubMed Central

    Palma, Guillermo; Vidal, Maria-Esther; Haag, Eric; Raschid, Louiqa; Thor, Andreas

    2015-01-01

    Linked Open Data initiatives have made available a diversity of scientific collections where scientists have annotated entities in the datasets with controlled vocabulary terms from ontologies. Annotations encode scientific knowledge, which is captured in annotation datasets. Determining relatedness between annotated entities becomes a building block for pattern mining, e.g. identifying drug–drug relationships may depend on the similarity of the targets that interact with each drug. A diversity of similarity measures has been proposed in the literature to compute relatedness between a pair of entities. Each measure exploits some knowledge including the name, function, relationships with other entities, taxonomic neighborhood and semantic knowledge. We propose a novel general-purpose annotation similarity measure called ‘AnnSim’ that measures the relatedness between two entities based on the similarity of their annotations. We model AnnSim as a 1–1 maximum weight bipartite match and exploit properties of existing solvers to provide an efficient solution. We empirically study the performance of AnnSim on real-world datasets of drugs and disease associations from clinical trials and relationships between drugs and (genomic) targets. Using baselines that include a variety of measures, we identify where AnnSim can provide a deeper understanding of the semantics underlying the relatedness of a pair of entities or where it could lead to predicting new links or identifying potential novel patterns. Although AnnSim does not exploit knowledge or properties of a particular domain, its performance compares well with a variety of state-of-the-art domain-specific measures. Database URL: http://www.yeastgenome.org/ PMID:25725057

  19. Rasmussen's Aneurysm: A Forgotten Entity?

    SciTech Connect

    Keeling, A. N.; Costello, R.; Lee, M. J.

    2008-01-15

    We present the case of a rare entity which is a complication of a disease process that had almost disappeared from the Western World. With the recent resurgence in reported cases of Mycobacterium tuberculosis (TB) in Western communities, it is important to recognize complications and sequelae. A young alcoholic male with confirmed active TB suffered a cardiac arrest following massive haemoptysis. Multidetector computed tomography angiography diagnosed a Rasmussen's aneurysm, confirmed by digital subtraction angiography and then successfully embolized with glue. We outline this rare case and the embolization technique and review previously documented reports.

  20. MicroRNA-138 acts as a tumor suppressor in non small cell lung cancer via targeting YAP1

    PubMed Central

    Xiao, Ling; Zhou, Hui; Li, Xiang-Ping; Chen, Juan; Fang, Chao; Mao, Chen-Xue; Cui, Jia-Jia; Zhang, Wei; Zhou, Hong-Hao; Yin, Ji-Ye; Liu, Zhao-Qian

    2016-01-01

    MicroRNA (miR)-138 was found to have suppressive effects on the growth and metastasis of different human cancers. In this study, we aimed to investigate the regulatory mechanism of miR-138 in non-small cell lung cancer (NSCLC). We applied the Quantitative real-time PCR (qRT-PCR) to detect the miR-138 levels in NSCLC tissues (n=21) and cell lines, Bioinformatical predication, luciferase reporter assay and western blot to identify the target gene of miR-138. We also applied Cell transfection, MTT, transwell, and wound healing assays to reveal the role of miR-138 in NSCLC cell proliferation and malignant transformation. We observed that miR-138 expression level was significantly decreased in NSCLC tissues compared to their matched adjacent normal tissues. It was also downregulated in tissues with poor differentiation, advanced stage or lymph nodes metastasis, as well as in several NSCLC cell lines compared to normal lung epithelial cell. We further identified YAP1 as a direct target gene of miR-138, and observed that the protein level of YAP1 was negatively mediated by miR-138 in NSCLC A549 cells. Moreover, overexpression of miR-138 significantly inhibited A549 cell growth, invasion and migration, while knockdown of miR-138 enhanced such capacities. Further investigation showed that the cell proliferation capacity was higher in the miR-138+YAP1 group, when compared with that in the miR-138 group, suggesting that overexpression of YAP1 rescued the suppressive effects of miR-138 upregulation on NSCLC cell proliferation. However, we found no difference of cell invasion and migration capacities between miR-138+YAP1 group and miR-138 group. Finally, YAP1 was markedly upregulated in NSCLC tissues compared to their marched adjacent normal tissues. Its mRNA levels were reversely correlated with the miR-138 levels in NSCLC tissues. In summary, our study suggests that miR-138 may play a suppressive role in the growth and metastasis of NSCLC cells partly at least by targeting

  1. Non-antibiotic quorum sensing inhibitors acting against N-acyl homoserine lactone synthase as druggable target

    PubMed Central

    Chang, Chien-Yi; Krishnan, Thiba; Wang, Hao; Chen, Ye; Yin, Wai-Fong; Chong, Yee-Meng; Tan, Li Ying; Chong, Teik Min; Chan, Kok-Gan

    2014-01-01

    N-acylhomoserine lactone (AHL)-based quorum sensing (QS) is important for the regulation of proteobacterial virulence determinants. Thus, the inhibition of AHL synthases offers non-antibiotics-based therapeutic potentials against QS-mediated bacterial infections. In this work, functional AHL synthases of Pseudomonas aeruginosa LasI and RhlI were heterologously expressed in an AHL-negative Escherichia coli followed by assessments on their AHLs production using AHL biosensors and high resolution liquid chromatography–mass spectrometry (LCMS). These AHL-producing E. coli served as tools for screening AHL synthase inhibitors. Based on a campaign of screening synthetic molecules and natural products using our approach, three strongest inhibitors namely are salicylic acid, tannic acid and trans-cinnamaldehyde have been identified. LCMS analysis further confirmed tannic acid and trans-cinnemaldehyde efficiently inhibited AHL production by RhlI. We further demonstrated the application of trans-cinnemaldehyde inhibiting Rhl QS system regulated pyocyanin production in P. aeruginosa up to 42.06%. Molecular docking analysis suggested that trans-cinnemaldehyde binds to the LasI and EsaI with known structures mainly interacting with their substrate binding sites. Our data suggested a new class of QS-inhibiting agents from natural products targeting AHL synthase and provided a potential approach for facilitating the discovery of anti-QS signal synthesis as basis of novel anti-infective approach. PMID:25430794

  2. Benzo[a]pyrene-induced nitric oxide production acts as a survival signal targeting mitochondrial membrane potential.

    PubMed

    Hardonnière, Kévin; Huc, Laurence; Podechard, Normand; Fernier, Morgane; Tekpli, Xavier; Gallais, Isabelle; Sergent, Odile; Lagadic-Gossmann, Dominique

    2015-10-01

    Benzo[a]pyrene (B[a]P), the prototype molecule of polycyclic aromatic hydrocarbons, exhibits genotoxic and carcinogenic effects, which has led the International Agency for Research on Cancer to recognize it as a human carcinogen. Besides the well-known apoptotic signals triggered by B[a]P, survival signals have also been suggested to occur, both signals likely involved in cancer promotion. Our previous work showed that B[a]P induced an hyperpolarization of mitochondrial membrane potential (ΔΨm) in rat hepatic epithelial F258 cells. Elevated ΔΨm plays a role in tumor development and progression, and nitric oxide (NO) has been suggested to be responsible for increases in ΔΨm. The present study therefore aimed at evaluating the impact of B[a]P on NO level in F258 cells, and at testing the putative role for NO as a survival signal, notably in link with ΔΨm. Our data demonstrated that B[a]P exposure resulted in an NO production which was dependent upon the activation of the inducible NO synthase. This enzyme activation involved AhR and possibly p53 activation. Preventing NO production not only increased B[a]P-induced cell death but also blocked mitochondrial hyperpolarization. This therefore points to a role for NO as a survival signal upon B[a]P exposure, possibly targeting ΔΨm.

  3. 20 CFR 670.310 - How are entities selected to receive funding?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... LABOR (CONTINUED) THE JOB CORPS UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Funding and Selection of... (c) and (d) of that Act apply. In selecting an entity, Job Corps issues requests for proposals (RFP... to Federal Acquisition Regulation (48 CFR Chapter 1) and DOL Acquisition Regulation (48 CFR...

  4. 20 CFR 670.310 - How are entities selected to receive funding?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Acquisition Regulation (48 CFR Chapter 1) and DOL Acquisition Regulation (48 CFR Chapter 29). Job Corps... LABOR THE JOB CORPS UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Funding and Selection of Service...) of that Act apply. In selecting an entity, Job Corps issues requests for proposals (RFP) for...

  5. 20 CFR 670.310 - How are entities selected to receive funding?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... LABOR (CONTINUED) THE JOB CORPS UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Funding and Selection of... (c) and (d) of that Act apply. In selecting an entity, Job Corps issues requests for proposals (RFP... to Federal Acquisition Regulation (48 CFR Chapter 1) and DOL Acquisition Regulation (48 CFR...

  6. Entity Network Prediction Using Multitype Topic Models

    NASA Astrophysics Data System (ADS)

    Shiozaki, Hitohiro; Eguchi, Koji; Ohkawa, Takenao

    Conveying information about who, what, when and where is a primary purpose of some genres of documents, typically news articles. Statistical models that capture dependencies between named entities and topics can play an important role. Although some relationships between who and where should be mentioned in such a document, no statistical topic models explicitly address in handling such information the textual interactions between a who-entity and a where-entity. This paper presents a statistical model that directly captures the dependencies between an arbitrary number of word types, such as who-entities, where-entities and topics, mentioned in each document. We show that this multitype topic model performs better at making predictions on entity networks, in which each vertex represents an entity and each edge weight represents how a pair of entities at the incident vertices is closely related, through our experiments on predictions of who-entities and links between them. We also demonstrate the scale-free property in the weighted networks of entities extracted from written mentions.

  7. The Proteasome Acts as a Hub for Plant Immunity and Is Targeted by Pseudomonas Type III Effectors1[OPEN

    PubMed Central

    Sheikh, Arsheed; Gimenez-Ibanez, Selena

    2016-01-01

    Recent evidence suggests that the ubiquitin-proteasome system is involved in several aspects of plant immunity and that a range of plant pathogens subvert the ubiquitin-proteasome system to enhance their virulence. Here, we show that proteasome activity is strongly induced during basal defense in Arabidopsis (Arabidopsis thaliana). Mutant lines of the proteasome subunits RPT2a and RPN12a support increased bacterial growth of virulent Pseudomonas syringae pv tomato DC3000 (Pst) and Pseudomonas syringae pv maculicola ES4326. Both proteasome subunits are required for pathogen-associated molecular pattern-triggered immunity responses. Analysis of bacterial growth after a secondary infection of systemic leaves revealed that the establishment of systemic acquired resistance (SAR) is impaired in proteasome mutants, suggesting that the proteasome also plays an important role in defense priming and SAR. In addition, we show that Pst inhibits proteasome activity in a type III secretion-dependent manner. A screen for type III effector proteins from Pst for their ability to interfere with proteasome activity revealed HopM1, HopAO1, HopA1, and HopG1 as putative proteasome inhibitors. Biochemical characterization of HopM1 by mass spectrometry indicates that HopM1 interacts with several E3 ubiquitin ligases and proteasome subunits. This supports the hypothesis that HopM1 associates with the proteasome, leading to its inhibition. Thus, the proteasome is an essential component of pathogen-associated molecular pattern-triggered immunity and SAR, which is targeted by multiple bacterial effectors. PMID:27613851

  8. miR-506 acts as a tumor suppressor by directly targeting the hedgehog pathway transcription factor Gli3 in human cervical cancer.

    PubMed

    Wen, S-Y; Lin, Y; Yu, Y-Q; Cao, S-J; Zhang, R; Yang, X-M; Li, J; Zhang, Y-L; Wang, Y-H; Ma, M-Z; Sun, W-W; Lou, X-L; Wang, J-H; Teng, Y-C; Zhang, Z-G

    2015-02-05

    Although significant advances have recently been made in the diagnosis and treatment of cervical carcinoma, the long-term survival rate for advanced cervical cancer remains low. Therefore, an urgent need exists to both uncover the molecular mechanisms and identify potential therapeutic targets for the treatment of cervical cancer. MicroRNAs (miRNAs) have important roles in cancer progression and could be used as either potential therapeutic agents or targets. miR-506 is a component of an X chromosome-linked miRNA cluster. The biological functions of miR-506 have not been well established. In this study, we found that miR-506 expression was downregulated in approximately 80% of the cervical cancer samples examined and inversely correlated with the expression of Ki-67, a marker of cell proliferation. Gain-of-function and loss-of-function studies in human cervical cancer, Caski and SiHa cells, demonstrated that miR-506 acts as a tumor suppressor by inhibiting cervical cancer growth in vitro and in vivo. Further studies showed that miR-506 induced cell cycle arrest at the G1/S transition, and enhanced apoptosis and chemosensitivity of cervical cancer cell. We subsequently identified Gli3, a hedgehog pathway transcription factor, as a direct target of miR-506 in cervical cancer. Furthermore, Gli3 silencing recapitulated the effects of miR-506, and reintroduction of Gli3 abrogated miR-506-induced cell growth arrest and apoptosis. Taken together, we conclude that miR-506 exerts its anti-proliferative function by directly targeting Gli3. This newly identified miR-506/Gli3 axis provides further insight into the pathogenesis of cervical cancer and indicates a potential novel therapeutic agent for the treatment of cervical cancer.

  9. N,N'-alkylated Imidazolium-derivatives act as quorum-sensing inhibitors targeting the Pectobacterium atrosepticum-induced symptoms on potato tubers.

    PubMed

    des Essarts, Yannick Raoul; Sabbah, Mohamad; Comte, Arnaud; Soulère, Laurent; Queneau, Yves; Dessaux, Yves; Hélias, Valérie; Faure, Denis

    2013-10-08

    Bacteria belonging to the Pectobacterium genus are the causative agents of the blackleg and soft-rot diseases that affect potato plants and tubers worldwide. In Pectobacterium, the expression of the virulence genes is controlled by quorum-sensing (QS) and N-acylhomoserine lactones (AHLs). In this work, we screened a chemical library of QS-inhibitors (QSIs) and AHL-analogs to find novel QSIs targeting the virulence of Pectobacterium. Four N,N'-bisalkylated imidazolium salts were identified as QSIs; they were active at the µM range. In potato tuber assays, two of them were able to decrease the severity of the symptoms provoked by P. atrosepticum. This work extends the range of the QSIs acting on the Pectobacterium-induced soft-rot disease.

  10. Dementia: Continuum or Distinct Entity?

    PubMed Central

    Walters, Glenn D.

    2009-01-01

    The latent structure of dementia was examined in a group of 10,775 older adults with indicators derived from a neuropsychological test battery. Subjecting these data to taxometric analysis using mean above minus below a cut (MAMBAC), maximum covariance (MAXCOV), and latent mode factor analysis (L-Mode) produced results more consistent with dementia as a dimensional (lying along a continuum) than categorical (representing a distinct entity) construct. A second study conducted on a group of 2375 21-to-64-year olds produced similar results. These findings denote that dementia, as measured by deficits in episodic memory, attention/concentration, executive function, and language, differs quantitatively rather than qualitatively from the cognitive status of non-demented adults. The implications of these results for classification, assessment, etiology, and prevention are discussed. PMID:20677881

  11. 20 CFR 668.520 - Must INA grantees give preference to Indian/Native American entities in the selection of...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    .../Native American entities in the selection of contractors or service providers? 668.520 Section 668.520... NATIVE AMERICAN PROGRAMS UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Services to Communities § 668.520 Must INA grantees give preference to Indian/Native American entities in the selection of contractors...

  12. 20 CFR 668.520 - Must INA grantees give preference to Indian/Native American entities in the selection of...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    .../Native American entities in the selection of contractors or service providers? 668.520 Section 668.520... NATIVE AMERICAN PROGRAMS UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Services to Communities § 668.520 Must INA grantees give preference to Indian/Native American entities in the selection of contractors...

  13. 20 CFR 668.520 - Must INA grantees give preference to Indian/Native American entities in the selection of...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    .../Native American entities in the selection of contractors or service providers? 668.520 Section 668.520... NATIVE AMERICAN PROGRAMS UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Services to Communities § 668.520 Must INA grantees give preference to Indian/Native American entities in the selection of contractors...

  14. 20 CFR 668.250 - What happens if two or more entities apply for the same area?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., DEPARTMENT OF LABOR INDIAN AND NATIVE AMERICAN PROGRAMS UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Service Delivery Systems Applicable to Section 166 Programs § 668.250 What happens if two or more entities apply... or more entities apply for grants for the same service area, or for overlapping service areas, and...

  15. 77 FR 29755 - Advisory Group to the Internal Revenue Service Tax Exempt and Government Entities Division (TE/GE...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-18

    ... Organizations, and Government Entities. Reports from five ACT subgroups cover the following topics: Employee... Governments: --Report on the General Welfare Doctrine as Applied to Indian Tribal Governments and Their... Revenue Service Tax Exempt and Government Entities Division (TE/GE); Meeting AGENCY: Internal...

  16. Federal Funding Accountability and Transparency Act

    EPA Pesticide Factsheets

    Public Law 109-282, the Federal Funding Accountability and Transparency Act of 2006 as amended (FFATA), requires disclosure of all entities and organizations receiving Federal funds through a single publicly accessible website.

  17. Brassinosteriod Insensitive 2 (BIN2) acts as a downstream effector of the Target of Rapamycin (TOR) signaling pathway to regulate photoautotrophic growth in Arabidopsis.

    PubMed

    Xiong, Fangjie; Zhang, Rui; Meng, Zhigang; Deng, Kexuan; Que, Yumei; Zhuo, Fengping; Feng, Li; Guo, Sundui; Datla, Raju; Ren, Maozhi

    2017-01-01

    The components of the target of rapamycin (TOR) signaling pathway have been well characterized in heterotrophic organisms from yeast to humans. However, because of rapamycin insensitivity, embryonic lethality in tor null mutants and a lack of reliable ways of detecting TOR protein kinase in higher plants, the key players upstream and downstream of TOR remain largely unknown in plants. Using engineered rapamycin-sensitive Binding Protein 12-2 (BP12-2) plants, the present study showed that combined treatment with rapamycin and active-site TOR inhibitors (asTORis) results in synergistic inhibition of TOR activity and plant growth in Arabidopsis. Based on this system, we revealed that TOR signaling plays a crucial role in modulating the transition from heterotrophic to photoautotrophic growth in Arabidopsis. Ribosomal protein S6 kinase 2 (S6K2) was identified as a direct downstream target of TOR, and the growth of TOR-suppressed plants could be rescued by up-regulating S6K2. Systems, genetic, and biochemical analyses revealed that Brassinosteriod Insensitive 2 (BIN2) acts as a novel downstream effector of S6K2, and the phosphorylation of BIN2 depends on TOR-S6K2 signaling in Arabidopsis. By combining pharmacological with genetic and biochemical approaches, we determined that the TOR-S6K2-BIN2 signaling pathway plays important roles in regulating the photoautotrophic growth of Arabidopsis.

  18. Proton pump inhibitor responsive esophageal eosinophilia, a distinct disease entity?

    PubMed

    Munday, William; Zhang, Xuchen

    2014-08-14

    Recent studies have suggested the existence of a patient population with esophageal eosinophilia that responds to proton pump inhibitor therapy. These patients are being referred to as having proton pump inhibitor responsive esophageal eosinophilia (PPI-REE), which is currently classified as a distinct and separate disease entity from both gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE). The therapeutic effect of proton pump inhibitor (PPI) on PPI-REE is thought to act directly at the level of the esophageal mucosa with an anti-inflammatory capacity, and completely independent of gastric acid suppression. The purpose of this manuscript is to review the mechanistic data of the proposed immune modulation/anti-inflammatory role of the PPI at the esophageal mucosa, and the existence of PPI-REE as a distinct disease entity from GERD and EoE.

  19. 22 CFR 96.71 - Review by the accrediting entity of complaints against accredited agencies and approved persons.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... INTERCOUNTRY ADOPTION ACT OF 2000 (IAA) Oversight Through Review of Complaints § 96.71 Review by the... subpart K of this part. (c) When the accrediting entity has completed its complaint review process,...

  20. 22 CFR 96.71 - Review by the accrediting entity of complaints against accredited agencies and approved persons.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... INTERCOUNTRY ADOPTION ACT OF 2000 (IAA) Oversight Through Review of Complaints § 96.71 Review by the... subpart K of this part. (c) When the accrediting entity has completed its complaint review process,...

  1. 78 FR 12135 - List of Participating Countries and Entities (Hereinafter Known as “Participants”) Under the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-21

    ... Participating Countries and Entities (Hereinafter Known as ``Participants'') Under the Clean Diamond Trade Act.... ACTION: Notice. SUMMARY: In accordance with Sections 3 and 6 of the Clean Diamond Trade Act of 2003 (Pub... identifying all the Participants eligible for trade in rough diamonds under the Act, and their...

  2. 76 FR 68396 - Privacy Act of 1974, as Amended

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-04

    ... criminal law proceedings; (8) Appropriate agencies, entities, and persons, to the extent necessary to... criminal law, rule, regulation, order, policy or license; (10) An entity or person that is the subject of... Street Reform and Consumer Financial Protection Act (``Act''), Public Law 111-203, Title X,...

  3. PRIS at TREC 2010: Related Entity Finding Task of Entity Track

    DTIC Science & Technology

    2010-11-01

    constructing retrieval model and allocating homepages for entities. We also used some external resources, such as Stanford NER Tool, Indri1 & Lemur ...obtained less than 1,000 documents. This information was stored for the latter needs. In order to indexing by Indri or Lemur , we parsed the...priority to entities extracted manually PRIS3 Entity-Centered Model by Indri PRIS4 Entity-Centered Model by Lemur (BM25) Because the evaluation

  4. 31 CFR 800.211 - Entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 800.211 Section 800.211 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF INVESTMENT... separate legal entity) operated by any one of the foregoing as a business undertaking in a...

  5. 47 CFR 27.502 - Designated entities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Competitive Bidding Procedures for the 698-806 MHz Band § 27.502 Designated entities. Eligibility for small business provisions: (a)(1) A small business is an entity that, together with...

  6. 47 CFR 24.321 - Designated entities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PERSONAL COMMUNICATIONS... for small business provisions. (1) A small business is an entity that, together with its controlling... years. (2) A very small business is an entity that, together with its controlling interests...

  7. 46 CFR 403.110 - Accounting entities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Accounting entities. 403.110 Section 403.110 Shipping COAST GUARD (GREAT LAKES PILOTAGE), DEPARTMENT OF HOMELAND SECURITY GREAT LAKES PILOTAGE UNIFORM ACCOUNTING SYSTEM General § 403.110 Accounting entities. Each Association shall be a separate...

  8. 46 CFR 403.110 - Accounting entities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false Accounting entities. 403.110 Section 403.110 Shipping COAST GUARD (GREAT LAKES PILOTAGE), DEPARTMENT OF HOMELAND SECURITY GREAT LAKES PILOTAGE UNIFORM ACCOUNTING SYSTEM General § 403.110 Accounting entities. Each Association shall be a separate...

  9. 46 CFR 403.110 - Accounting entities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false Accounting entities. 403.110 Section 403.110 Shipping COAST GUARD (GREAT LAKES PILOTAGE), DEPARTMENT OF HOMELAND SECURITY GREAT LAKES PILOTAGE UNIFORM ACCOUNTING SYSTEM General § 403.110 Accounting entities. Each Association shall be a separate...

  10. 46 CFR 403.110 - Accounting entities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Accounting entities. 403.110 Section 403.110 Shipping COAST GUARD (GREAT LAKES PILOTAGE), DEPARTMENT OF HOMELAND SECURITY GREAT LAKES PILOTAGE UNIFORM ACCOUNTING SYSTEM General § 403.110 Accounting entities. Each Association shall be a separate...

  11. 31 CFR 546.304 - Entity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Entity. 546.304 Section 546.304 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY DARFUR SANCTIONS REGULATIONS General Definitions § 546.304 Entity....

  12. 31 CFR 546.304 - Entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 546.304 Section 546.304 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY DARFUR SANCTIONS REGULATIONS General Definitions § 546.304 Entity....

  13. 31 CFR 575.303 - Entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 575.303 Section 575.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY IRAQI SANCTIONS REGULATIONS General Definitions § 575.303 Entity....

  14. 31 CFR 546.304 - Entity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Entity. 546.304 Section 546.304 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY DARFUR SANCTIONS REGULATIONS General Definitions § 546.304 Entity....

  15. 47 CFR 27.807 - Designated entities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Designated entities. 27.807 Section 27.807 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES 1.4 GHz Band § 27.807 Designated entities. (a) Eligibility for small business...

  16. 47 CFR 27.702 - Designated entities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Designated entities. 27.702 Section 27.702 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Competitive Bidding Procedures for the 698-746 MHz Band § 27.702 Designated entities....

  17. 47 CFR 27.807 - Designated entities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Designated entities. 27.807 Section 27.807 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES 1.4 GHz Band § 27.807 Designated entities. (a) Eligibility for small business...

  18. 47 CFR 27.906 - Designated entities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 2 2014-10-01 2014-10-01 false Designated entities. 27.906 Section 27.906 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES 1670-1675 MHz Band § 27.906 Designated entities. (a) Eligibility for small...

  19. 47 CFR 27.807 - Designated entities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Designated entities. 27.807 Section 27.807 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES 1.4 GHz Band § 27.807 Designated entities. (a) Eligibility for small business...

  20. 47 CFR 27.702 - Designated entities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Designated entities. 27.702 Section 27.702 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Competitive Bidding Procedures for the 698-746 MHz Band § 27.702 Designated entities....

  1. 47 CFR 27.906 - Designated entities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Designated entities. 27.906 Section 27.906 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES 1670-1675 MHz Band § 27.906 Designated entities. (a) Eligibility for small...

  2. 47 CFR 27.807 - Designated entities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 2 2012-10-01 2012-10-01 false Designated entities. 27.807 Section 27.807 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES 1.4 GHz Band § 27.807 Designated entities. (a) Eligibility for small business...

  3. 47 CFR 27.906 - Designated entities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 2 2012-10-01 2012-10-01 false Designated entities. 27.906 Section 27.906 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES 1670-1675 MHz Band § 27.906 Designated entities. (a) Eligibility for small...

  4. 47 CFR 27.702 - Designated entities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 2 2012-10-01 2012-10-01 false Designated entities. 27.702 Section 27.702 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Competitive Bidding Procedures for the 698-746 MHz Band § 27.702 Designated entities....

  5. 47 CFR 27.807 - Designated entities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 2 2014-10-01 2014-10-01 false Designated entities. 27.807 Section 27.807 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES 1.4 GHz Band § 27.807 Designated entities. (a) Eligibility for small business...

  6. 47 CFR 27.906 - Designated entities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Designated entities. 27.906 Section 27.906 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES 1670-1675 MHz Band § 27.906 Designated entities. (a) Eligibility for small...

  7. 47 CFR 27.906 - Designated entities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Designated entities. 27.906 Section 27.906 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES 1670-1675 MHz Band § 27.906 Designated entities. (a) Eligibility for small...

  8. 47 CFR 101.538 - Designated entities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Designated entities. 101.538 Section 101.538 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES 24 GHz Service and Digital Electronic Message Service § 101.538 Designated entities....

  9. 31 CFR 552.303 - Entity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Entity. 552.303 Section 552.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY YEMEN SANCTIONS REGULATIONS General Definitions § 552.303 Entity....

  10. 31 CFR 552.303 - Entity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Entity. 552.303 Section 552.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY YEMEN SANCTIONS REGULATIONS General Definitions § 552.303 Entity....

  11. 46 CFR 403.110 - Accounting entities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Accounting entities. 403.110 Section 403.110 Shipping COAST GUARD (GREAT LAKES PILOTAGE), DEPARTMENT OF HOMELAND SECURITY GREAT LAKES PILOTAGE UNIFORM ACCOUNTING SYSTEM General § 403.110 Accounting entities. Each Association shall be a separate...

  12. 31 CFR 542.303 - Entity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Entity. 542.303 Section 542.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY SYRIAN SANCTIONS REGULATIONS General Definitions § 542.303 Entity....

  13. 31 CFR 542.303 - Entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 542.303 Section 542.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY SYRIAN SANCTIONS REGULATIONS General Definitions § 542.303 Entity....

  14. 31 CFR 542.303 - Entity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Entity. 542.303 Section 542.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY SYRIAN SANCTIONS REGULATIONS General Definitions § 542.303 Entity....

  15. 31 CFR 542.303 - Entity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Entity. 542.303 Section 542.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY SYRIAN SANCTIONS REGULATIONS General Definitions § 542.303 Entity....

  16. 31 CFR 542.303 - Entity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Entity. 542.303 Section 542.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY SYRIAN SANCTIONS REGULATIONS General Definitions § 542.303 Entity....

  17. 47 CFR 1.2110 - Designated entities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... small businesses, businesses owned by members of minority groups and/or women, and rural telephone... management committee; (B) The entity has authority to appoint, promote, demote, and fire senior executives that control the day-to-day activities of the licensee; and (C) The entity plays an integral role...

  18. 47 CFR 1.2110 - Designated entities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., and the entities with which it has an attributable material relationship shall be attributed to the... attributable material relationship. (ii) If applicable, pursuant to § 24.709 of this chapter, the total assets... controlling interests, and the entities with which it has an attributable material relationship shall...

  19. 47 CFR 101.538 - Designated entities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Designated entities. 101.538 Section 101.538 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES 24 GHz Service and Digital Electronic Message Service § 101.538 Designated entities....

  20. 47 CFR 101.538 - Designated entities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Designated entities. 101.538 Section 101.538 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES 24 GHz Service and Digital Electronic Message Service § 101.538 Designated entities....

  1. 47 CFR 101.538 - Designated entities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Designated entities. 101.538 Section 101.538 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES 24 GHz Service and Digital Electronic Message Service § 101.538 Designated entities....

  2. 47 CFR 101.538 - Designated entities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Designated entities. 101.538 Section 101.538 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES 24 GHz Service and Digital Electronic Message Service § 101.538 Designated entities....

  3. Targeted Lethal Force Transparency Act

    THOMAS, 113th Congress

    Rep. Schiff, Adam B. [D-CA-28

    2014-04-02

    04/02/2014 Referred to the Committee on Intelligence (Permanent Select), and in addition to the Committee on Armed Services, for a period to be subsequently determined by the Speaker, in each case for consideration of such provisions as fall within the jurisdiction of the committee... (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  4. Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents.

    PubMed

    Olmstead, Andrea D; Knecht, Wolfgang; Lazarov, Ina; Dixit, Surjit B; Jean, François

    2012-01-01

    HCV infection is a major risk factor for liver cancer and liver transplantation worldwide. Overstimulation of host lipid metabolism in the liver by HCV-encoded proteins during viral infection creates a favorable environment for virus propagation and pathogenesis. In this study, we hypothesize that targeting cellular enzymes acting as master regulators of lipid homeostasis could represent a powerful approach to developing a novel class of broad-spectrum antivirals against infection associated with human Flaviviridae viruses such as hepatitis C virus (HCV), whose assembly and pathogenesis depend on interaction with lipid droplets (LDs). One such master regulator of cholesterol metabolic pathways is the host subtilisin/kexin-isozyme-1 (SKI-1)--or site-1 protease (S1P). SKI-1/S1P plays a critical role in the proteolytic activation of sterol regulatory element binding proteins (SREBPs), which control expression of the key enzymes of cholesterol and fatty-acid biosynthesis. Here we report the development of a SKI-1/S1P-specific protein-based inhibitor and its application to blocking the SREBP signaling cascade. We demonstrate that SKI-1/S1P inhibition effectively blocks HCV from establishing infection in hepatoma cells. The inhibitory mechanism is associated with a dramatic reduction in the abundance of neutral lipids, LDs, and the LD marker: adipose differentiation-related protein (ADRP)/perilipin 2. Reduction of LD formation inhibits virus assembly from infected cells. Importantly, we confirm that SKI-1/S1P is a key host factor for HCV infection by using a specific active, site-directed, small-molecule inhibitor of SKI-1/S1P: PF-429242. Our studies identify SKI-1/S1P as both a novel regulator of the HCV lifecycle and as a potential host-directed therapeutic target against HCV infection and liver steatosis. With identification of an increasing number of human viruses that use host LDs for infection, our results suggest that SKI-1/S1P inhibitors may allow development of

  5. Environmental Restoration of Corrective Action Unit 408: Bomblet Target Area, Tonopah Test Range, Nevada (Funded by the American Reinvestment and Recovery Act)

    SciTech Connect

    Kevin Cabble , Mark Burmeister and Mark Krauss

    2011-03-03

    The mission of the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) Environmental Restoration Program is to address the environmental impacts of weapons testing conducted on the Nevada National Security Site and the Nevada Test and Training Range. The large physical size of these sites, along with limits on funding and other resources available for remediation efforts, means that environmental restoration activities must be prioritized and accomplished incrementally over time. The remediation of a bomblet target area on the Tonopah Test Range (TTR), which is located within the Nevada Test and Training Range, was originally planned in 2007 but was not carried out until funding became available in the summer of 2009 through the American Reinvestment and Recovery Act. This activity was implemented in accordance with the Federal Facility Agreement and Consent Order established between NNSA/NSO and the Nevada Division of Environmental Protection. This activity which was complete by the end of Fiscal Year 2010, involved the excavation of disposal pits suspected of containing submunitions and the surface clearance of submunitions on seven target areas amounting to approximately 6.7 square kilometers of land at the TTR. The TTR was used by Sandia National Laboratories from the late 1960s through the mid-1980s to conduct research into the deployment of submunitions. Although there were efforts to identify, collect, and dispose various amounts of unexploded ordnance on the TTR in the past, no comprehensive effort to remediate the entire flightline area for submunitions was undertaken before this project.

  6. Multitarget drugs of plants origin acting on Alzheimer's disease.

    PubMed

    Russo, P; Frustaci, A; Del Bufalo, A; Fini, M; Cesario, A

    2013-01-01

    The etiopathology of Alzheimer's disease (AD) is extremely complex and heterogeneous, often associated with comorbidities. As a result it may be unlikely that AD may be mitigated by drug acting on a single specific target. The current tendency in drug design and discovery in AD is the rational design or "serendipitous" discovery of new drug entities challenging multiple targets. Since two of the presently approved drugs for AD are based on natural products (galantamine and the physostigmine-derivative rivastigmine), many plants are now under investigation as a potential source of new drugs. Multifunctional drugs often have their origin in natural sources. This review is limited to plant chemicals having different targets with actual (galantamine) or promising (drugs from Crocus sativus, Ginkgo biloba, Salvia species, and Huperzia serrata) clinical evidence in people with dementia or AD.

  7. Increasing Targeting, Flexibility, and Transparency in Title I of the Elementary and Secondary Education Act to Help Disadvantaged Students. Policy Proposal 2016-01

    ERIC Educational Resources Information Center

    Gordon, Nora

    2016-01-01

    Public discussion leading up to the reauthorization of the Elementary and Secondary Education Act (ESEA) of 1965 as the Every Student Succeeds Act (ESSA) in December 2015 focused on the controversial testing, standards, and teacher evaluation provisions of the previous reauthorization, the No Child Left Behind Act of 2001 (NCLB; 2002), and its…

  8. Increasing Targeting, Flexibility, and Transparency in Title I of the Elementary and Secondary Education Act to Help Disadvantaged Students. Policy Proposal 2016-01

    ERIC Educational Resources Information Center

    Gordon, Nora

    Public discussion leading up to the reauthorization of the Elementary and Secondary Education Act (ESEA) of 1965 as the Every Student Succeeds Act (ESSA) in December 2015 focused on the controversial testing, standards, and teacher evaluation provisions of the previous reauthorization, the No Child Left Behind Act of 2001 (NCLB; 2002), and its…

  9. 47 CFR 22.229 - Designated entities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... entrepreneur is an entity that, together with its controlling interests and affiliates, has average annual... entrepreneur, as defined in this section, or a consortium of entrepreneurs may use the bidding credit...

  10. 18 CFR 46.5 - Covered entities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., or a savings and loan association; (b) Any entity which is authorized by law to underwrite or... electrical equipment or coal, natural gas, oil, nuclear fuel, or other fuel, for the use of any...

  11. A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR.

    PubMed

    Tosco, A; De Gregorio, F; Esposito, S; De Stefano, D; Sana, I; Ferrari, E; Sepe, A; Salvadori, L; Buonpensiero, P; Di Pasqua, A; Grassia, R; Leone, C A; Guido, S; De Rosa, G; Lusa, S; Bona, G; Stoll, G; Maiuri, M C; Mehta, A; Kroemer, G; Maiuri, L; Raia, V

    2016-08-01

    We previously reported that the combination of two safe proteostasis regulators, cysteamine and epigallocatechin gallate (EGCG), can be used to improve deficient expression of the cystic fibrosis transmembrane conductance regulator (CFTR) in patients homozygous for the CFTR Phe508del mutation. Here we provide the proof-of-concept that this combination treatment restored CFTR function and reduced lung inflammation (P<0.001) in Phe508del/Phe508del or Phe508del/null-Cftr (but not in Cftr-null mice), provided that such mice were autophagy-competent. Primary nasal cells from patients bearing different class II CFTR mutations, either in homozygous or compound heterozygous form, responded to the treatment in vitro. We assessed individual responses to cysteamine plus EGCG in a single-centre, open-label phase-2 trial. The combination treatment decreased sweat chloride from baseline, increased both CFTR protein and function in nasal cells, restored autophagy in such cells, decreased CXCL8 and TNF-α in the sputum, and tended to improve respiratory function. These positive effects were particularly strong in patients carrying Phe508del CFTR mutations in homozygosity or heterozygosity. However, a fraction of patients bearing other CFTR mutations failed to respond to therapy. Importantly, the same patients whose primary nasal brushed cells did not respond to cysteamine plus EGCG in vitro also exhibited deficient therapeutic responses in vivo. Altogether, these results suggest that the combination treatment of cysteamine plus EGCG acts 'on-target' because it can only rescue CFTR function when autophagy is functional (in mice) and improves CFTR function when a rescuable protein is expressed (in mice and men). These results should spur the further clinical development of the combination treatment.

  12. DLX1 acts as a crucial target of FOXM1 to promote ovarian cancer aggressiveness by enhancing TGF-β/SMAD4 signaling

    PubMed Central

    Chan, D W; Hui, W W Y; Wang, J J; Yung, M M H; Hui, L M N; Qin, Y; Liang, R R; Leung, T H Y; Xu, D; Chan, K K L; Yao, K-M; Tsang, B K; Ngan, H Y S

    2017-01-01

    Recent evidence from a comprehensive genome analysis and functional studies have revealed that FOXM1 is a crucial metastatic regulator that drives cancer progression. However, the regulatory mechanism by which FOXM1 exerts its metastatic functions in cancer cells remains obscure. Here, we report that DLX1 acts as a FOXM1 downstream target, exerting pro-metastatic function in ovarian cancers. Both FOXM1 isoforms (FOXM1B or FOXM1C) could transcriptionally upregulate DLX1 through two conserved binding sites, located at +61 to +69bp downstream (TFBS1) and −675 to −667bp upstream (TFBS2) of the DLX1 promoter, respectively. This regulation was further accentuated by the significant correlation between the nuclear expression of FOXM1 and DLX1 in high-grade serous ovarian cancers. Functionally, the ectopic expression of DLX1 promoted ovarian cancer cell growth, cell migration/invasion and intraperitoneal dissemination of ovarian cancer in mice, whereas small interfering RNA-mediated DLX1 knockdown in FOXM1-overexpressing ovarian cancer cells abrogated these oncogenic capacities. In contrast, depletion of FOXM1 by shRNAi only partially attenuated tumor growth and exerted almost no effect on cell migration/invasion and the intraperitoneal dissemination of DLX1-overexpressing ovarian cancer cells. Furthermore, the mechanistic studies showed that DLX1 positively modulates transforming growth factor-β (TGF-β) signaling by upregulating PAI-1 and JUNB through direct interaction with SMAD4 in the nucleus upon TGF-β1 induction. Taken together, these data strongly suggest that DLX1 has a pivotal role in FOXM1 signaling to promote cancer aggressiveness through intensifying TGF-β/SMAD4 signaling in high-grade serous ovarian cancer cells. PMID:27593933

  13. A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR

    PubMed Central

    Tosco, A; De Gregorio, F; Esposito, S; De Stefano, D; Sana, I; Ferrari, E; Sepe, A; Salvadori, L; Buonpensiero, P; Di Pasqua, A; Grassia, R; Leone, C A; Guido, S; De Rosa, G; Lusa, S; Bona, G; Stoll, G; Maiuri, M C; Mehta, A; Kroemer, G; Maiuri, L; Raia, V

    2016-01-01

    We previously reported that the combination of two safe proteostasis regulators, cysteamine and epigallocatechin gallate (EGCG), can be used to improve deficient expression of the cystic fibrosis transmembrane conductance regulator (CFTR) in patients homozygous for the CFTR Phe508del mutation. Here we provide the proof-of-concept that this combination treatment restored CFTR function and reduced lung inflammation (P<0.001) in Phe508del/Phe508del or Phe508del/null-Cftr (but not in Cftr-null mice), provided that such mice were autophagy-competent. Primary nasal cells from patients bearing different class II CFTR mutations, either in homozygous or compound heterozygous form, responded to the treatment in vitro. We assessed individual responses to cysteamine plus EGCG in a single-centre, open-label phase-2 trial. The combination treatment decreased sweat chloride from baseline, increased both CFTR protein and function in nasal cells, restored autophagy in such cells, decreased CXCL8 and TNF-α in the sputum, and tended to improve respiratory function. These positive effects were particularly strong in patients carrying Phe508del CFTR mutations in homozygosity or heterozygosity. However, a fraction of patients bearing other CFTR mutations failed to respond to therapy. Importantly, the same patients whose primary nasal brushed cells did not respond to cysteamine plus EGCG in vitro also exhibited deficient therapeutic responses in vivo. Altogether, these results suggest that the combination treatment of cysteamine plus EGCG acts ‘on-target' because it can only rescue CFTR function when autophagy is functional (in mice) and improves CFTR function when a rescuable protein is expressed (in mice and men). These results should spur the further clinical development of the combination treatment. PMID:27035618

  14. 42 CFR 410.145 - Requirements for entities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... PROGRAM SUPPLEMENTARY MEDICAL INSURANCE (SMI) BENEFITS Outpatient Diabetes Self-Management Training and Diabetes Outcome Measurements § 410.145 Requirements for entities. (a) Deemed entities. (1) Except...

  15. 42 CFR 410.145 - Requirements for entities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... PROGRAM SUPPLEMENTARY MEDICAL INSURANCE (SMI) BENEFITS Outpatient Diabetes Self-Management Training and Diabetes Outcome Measurements § 410.145 Requirements for entities. (a) Deemed entities. (1) Except...

  16. 42 CFR 410.145 - Requirements for entities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... PROGRAM SUPPLEMENTARY MEDICAL INSURANCE (SMI) BENEFITS Outpatient Diabetes Self-Management Training and Diabetes Outcome Measurements § 410.145 Requirements for entities. (a) Deemed entities. (1) Except...

  17. 42 CFR 410.145 - Requirements for entities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... PROGRAM SUPPLEMENTARY MEDICAL INSURANCE (SMI) BENEFITS Outpatient Diabetes Self-Management Training and Diabetes Outcome Measurements § 410.145 Requirements for entities. (a) Deemed entities. (1) Except...

  18. 42 CFR 410.145 - Requirements for entities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PROGRAM SUPPLEMENTARY MEDICAL INSURANCE (SMI) BENEFITS Outpatient Diabetes Self-Management Training and Diabetes Outcome Measurements § 410.145 Requirements for entities. (a) Deemed entities. (1) Except...

  19. A meta-analysis of HLA peptidome composition in different hematological entities: Entity-specific dividing lines and "pan-leukemia" antigens.

    PubMed

    Backert, Linus; Kowalewski, Daniel Johannes; Walz, Simon; Schuster, Heiko; Berlin, Claudia; Neidert, Marian Christoph; Schemionek, Mirle; Brümmendorf, Tim H; Vucinic, Vladan; Niederwieser, Dietger; Kanz, Lothar; Salih, Helmut Rainer; Kohlbacher, Oliver; Weisel, Katja; Rammensee, Hans-Georg; StevanoviÄ, Stefan; Walz, Juliane Sarah

    2017-01-31

    Hematological malignancies (HM) are highly amenable targets for immunotherapeutic intervention and may be effectively treated by antigen-specific T-cell based treatment. Recent studies demonstrate that physiologically occurring anti-cancer T-cell responses in certain HM entities target broadly presented non-mutated epitopes. HLA ligands are thus implied as prime targets for broadly applicable and antigen-specific off-the-shelf compounds. With the aim of assessing the presence of common targets shared among different HM which may enable addressing a larger patient collective we conducted a meta-analysis of 83 mass spectrometry-based HLA peptidome datasets (comprising 40,361 unique peptide identifications) across four major HM (19 AML, 16 CML, 35 CLL, and 13 MM/MCL samples) and investigated similarities and differences within the HLA presented antigenic landscape. We found the cancer HLA peptidome datasets to cluster specifically along entity and lineage lines, suggesting that the immunopeptidome directly reflects the differences in the underlying (tumor-)biology. In line with these findings, we only detected a small set of entity-spanning antigens, which were predominantly characterized by low presentation frequencies within the different patient cohorts. These findings suggest that design of T-cell immunotherapies for the treatment of HM should ideally be conducted in an entity-specific fashion.

  20. Functionalization of polydopamine coated magnetic nanoparticles with biological entities

    NASA Astrophysics Data System (ADS)

    Mǎgeruşan, Lidia; Mrówczyński, Radosław; Turcu, Rodica

    2015-12-01

    New hybrid materials, obtained through introduction of cysteine, lysine and folic acid as biological entities into polydopamine-coated magnetite nanoparticles, are reported. The syntheses are straight forward and various methods were applied for structural and morphological characterization of the resulting nanoparticles. XPS proved a very powerful tool for surface chemical analysis and it evidences the functionalization of polydopamine coated magnetite nanoparticles. The superparamagnetic behavior and the high values of saturation magnetization recommend all products for further application where magnetism is important for targeting, separation, or heating by alternative magnetic fields.

  1. 16 CFR 802.40 - Exempt formation of corporations or unincorporated entities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Exempt formation of corporations or unincorporated entities. 802.40 Section 802.40 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 EXEMPTION...

  2. 16 CFR 802.40 - Exempt formation of corporations or unincorporated entities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Exempt formation of corporations or unincorporated entities. 802.40 Section 802.40 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 EXEMPTION...

  3. 16 CFR 802.41 - Corporations or unincorporated entities at time of formation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Corporations or unincorporated entities at time of formation. 802.41 Section 802.41 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF...

  4. 16 CFR 802.52 - Acquisitions by or from foreign governmental entities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Acquisitions by or from foreign governmental entities. 802.52 Section 802.52 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 EXEMPTION...

  5. 16 CFR 802.41 - Corporations or unincorporated entities at time of formation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Corporations or unincorporated entities at time of formation. 802.41 Section 802.41 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF...

  6. 16 CFR 802.40 - Exempt formation of corporations or unincorporated entities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Exempt formation of corporations or unincorporated entities. 802.40 Section 802.40 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 EXEMPTION...

  7. 16 CFR 802.40 - Exempt formation of corporations or unincorporated entities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Exempt formation of corporations or unincorporated entities. 802.40 Section 802.40 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 EXEMPTION...

  8. 16 CFR 802.41 - Corporations or unincorporated entities at time of formation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Corporations or unincorporated entities at time of formation. 802.41 Section 802.41 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF...

  9. 16 CFR 802.41 - Corporations or unincorporated entities at time of formation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Corporations or unincorporated entities at time of formation. 802.41 Section 802.41 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF...

  10. 16 CFR 802.41 - Corporations or unincorporated entities at time of formation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Corporations or unincorporated entities at time of formation. 802.41 Section 802.41 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF...

  11. 16 CFR 802.40 - Exempt formation of corporations or unincorporated entities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Exempt formation of corporations or unincorporated entities. 802.40 Section 802.40 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 EXEMPTION...

  12. 16 CFR 802.52 - Acquisitions by or from foreign governmental entities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Acquisitions by or from foreign governmental entities. 802.52 Section 802.52 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 EXEMPTION...

  13. 16 CFR 802.52 - Acquisitions by or from foreign governmental entities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Acquisitions by or from foreign governmental entities. 802.52 Section 802.52 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 EXEMPTION...

  14. 20 CFR 628.415 - Selection of SDA grant recipient and administrative entity.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Selection of SDA grant recipient and administrative entity. 628.415 Section 628.415 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR PROGRAMS UNDER TITLE II OF THE JOB TRAINING PARTNERSHIP ACT Local Service Delivery...

  15. 20 CFR 668.292 - How does a designated entity become an INA grantee?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false How does a designated entity become an INA grantee? 668.292 Section 668.292 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR INDIAN AND NATIVE AMERICAN PROGRAMS UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Service...

  16. 28 CFR 115.12 - Contracting with other entities for the confinement of inmates.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Contracting with other entities for the confinement of inmates. 115.12 Section 115.12 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Adult Prisons and Jails Prevention Planning §...

  17. 28 CFR 115.112 - Contracting with other entities for the confinement of detainees.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Contracting with other entities for the confinement of detainees. 115.112 Section 115.112 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Prevention Planning §...

  18. 28 CFR 115.12 - Contracting with other entities for the confinement of inmates.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Contracting with other entities for the confinement of inmates. 115.12 Section 115.12 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Adult Prisons and Jails Prevention Planning §...

  19. 28 CFR 115.12 - Contracting with other entities for the confinement of inmates.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Contracting with other entities for the confinement of inmates. 115.12 Section 115.12 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Adult Prisons and Jails Prevention Planning §...

  20. 28 CFR 115.312 - Contracting with other entities for the confinement of residents.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Contracting with other entities for the confinement of residents. 115.312 Section 115.312 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Juvenile Facilities Prevention...

  1. 28 CFR 115.112 - Contracting with other entities for the confinement of detainees.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Contracting with other entities for the confinement of detainees. 115.112 Section 115.112 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Prevention Planning §...

  2. 28 CFR 115.312 - Contracting with other entities for the confinement of residents.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Contracting with other entities for the confinement of residents. 115.312 Section 115.312 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Juvenile Facilities Prevention...

  3. 28 CFR 115.112 - Contracting with other entities for the confinement of detainees.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Contracting with other entities for the confinement of detainees. 115.112 Section 115.112 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Prevention Planning §...

  4. 28 CFR 115.312 - Contracting with other entities for the confinement of residents.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Contracting with other entities for the confinement of residents. 115.312 Section 115.312 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Juvenile Facilities Prevention...

  5. 77 FR 50425 - Clearing Exemption for Swaps Between Certain Affiliated Entities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-21

    ...The Commodity Futures Trading Commission (``CFTC'' or ``Commission'') is proposing a rule to exempt swaps between certain affiliated entities within a corporate group from the clearing requirement (the ``inter-affiliate clearing exemption'' or the ``proposed exemption'') under Section 2(h)(1)(A) of the Commodity Exchange Act (``CEA''). The Commission also is proposing rules that detail......

  6. 77 FR 27551 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-59; Small Entity Compliance Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ...This document is issued under the joint authority of DOD, GSA, and NASA. This Small Entity Compliance Guide has been prepared in accordance with section 212 of the Small Business Regulatory Enforcement Fairness Act of 1996. It consists of a summary of the rule appearing in Federal Acquisition Circular (FAC) 2005-59, which amends the Federal Acquisition Regulation (FAR). Interested parties may......

  7. Anatomical entity mention recognition at literature scale

    PubMed Central

    Pyysalo, Sampo; Ananiadou, Sophia

    2014-01-01

    Motivation: Anatomical entities ranging from subcellular structures to organ systems are central to biomedical science, and mentions of these entities are essential to understanding the scientific literature. Despite extensive efforts to automatically analyze various aspects of biomedical text, there have been only few studies focusing on anatomical entities, and no dedicated methods for learning to automatically recognize anatomical entity mentions in free-form text have been introduced. Results: We present AnatomyTagger, a machine learning-based system for anatomical entity mention recognition. The system incorporates a broad array of approaches proposed to benefit tagging, including the use of Unified Medical Language System (UMLS)- and Open Biomedical Ontologies (OBO)-based lexical resources, word representations induced from unlabeled text, statistical truecasing and non-local features. We train and evaluate the system on a newly introduced corpus that substantially extends on previously available resources, and apply the resulting tagger to automatically annotate the entire open access scientific domain literature. The resulting analyses have been applied to extend services provided by the Europe PubMed Central literature database. Availability and implementation: All tools and resources introduced in this work are available from http://nactem.ac.uk/anatomytagger. Contact: sophia.ananiadou@manchester.ac.uk Supplementary Information: Supplementary data are available at Bioinformatics online. PMID:24162468

  8. Entity Came to Rescue - Leveraging Entities to Minimize Risks in Web Search

    DTIC Science & Technology

    2014-11-01

    toolkit to perform entity extraction on extreme short text like queries with satisfying precision. Figure 1 demonstrates some example entity annotations...NOTES presented in the proceedings of the Twenty-Third Text REtrieval Conference (TREC 2014) held in Gaithersburg, Maryland, November 19-21, 2014

  9. 20 CFR 662.220 - What entity serves as the One-Stop partner for a particular program in the local area?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What entity serves as the One-Stop partner... TRAINING ADMINISTRATION, DEPARTMENT OF LABOR DESCRIPTION OF THE ONE-STOP SYSTEM UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT One-Stop Partners and the Responsibilities of Partners § 662.220 What entity...

  10. Biological entity recognition with conditional random fields.

    PubMed

    He, Ying; Kayaalp, Mehmet

    2008-11-06

    Due to the rapid evolution of molecular biology and the lack of naming standards, biological entity recognition (BER) remains a challenging task for information extraction and natural language understanding. In this study, we presented a statistical machine learning approach for extracting features, modeling, and predicting biological named entities. Our approach utilizes UMLS semantic types together with MetaMap, SemRep, and ABGene, as well as the conditional random fields (CRF) framework, and learns both the structure and parameters of a statistical model. Results of this study are competitive with the results of the state of the art tools in this field. Unlike competing similar approaches, the presented method is fully automatic, hence more generalizable and directly transferable to other named entity recognition (NER) problems in medical informatics.

  11. 12 CFR 1237.10 - Limited-life regulated entities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 9 2013-01-01 2013-01-01 false Limited-life regulated entities. 1237.10... RECEIVERSHIP Limited-Life Regulated Entities § 1237.10 Limited-life regulated entities. (a) Status. The United... liquidity portfolio of a limited-life regulated entity. (c) Policies and procedures. The Agency may...

  12. 12 CFR 1237.10 - Limited-life regulated entities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Limited-life regulated entities. 1237.10... RECEIVERSHIP Limited-Life Regulated Entities § 1237.10 Limited-life regulated entities. (a) Status. The United... liquidity portfolio of a limited-life regulated entity. (c) Policies and procedures. The Agency may...

  13. 12 CFR 1237.10 - Limited-life regulated entities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Limited-life regulated entities. 1237.10... RECEIVERSHIP Limited-Life Regulated Entities § 1237.10 Limited-life regulated entities. (a) Status. The United... liquidity portfolio of a limited-life regulated entity. (c) Policies and procedures. The Agency may...

  14. 17 CFR 45.6 - Legal entity identifiers

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... entity or entities in the record. (c) Governance principles for the legal entity identifier. The legal... conform to the governance principles set forth in paragraphs (c)(1) through (4) of this section. (1) International governance. The issuance of the legal entity identifier used pursuant to this section, and...

  15. 17 CFR 45.6 - Legal entity identifiers

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... entity or entities in the record. (c) Governance principles for the legal entity identifier. The legal... conform to the governance principles set forth in paragraphs (c)(1) through (4) of this section. (1) International governance. The issuance of the legal entity identifier used pursuant to this section, and...

  16. 17 CFR 45.6 - Legal entity identifiers

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... entity or entities in the record. (c) Governance principles for the legal entity identifier. The legal... conform to the governance principles set forth in paragraphs (c)(1) through (4) of this section. (1) International governance. The issuance of the legal entity identifier used pursuant to this section, and...

  17. 37 CFR 1.29 - Micro entity status.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Micro entity status. 1.29... Micro entity status. (a) To establish micro entity status under this paragraph, the applicant must... establish micro entity status under this paragraph, the applicant must certify that: (1) The...

  18. 37 CFR 1.29 - Micro entity status.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Micro entity status. 1.29... Micro entity status. (a) To establish micro entity status under this paragraph, the applicant must... establish micro entity status under this paragraph, the applicant must certify that: (1) The...

  19. 26 CFR 301.7701-2 - Business entities; definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 18 2011-04-01 2011-04-01 false Business entities; definitions. 301.7701-2...) PROCEDURE AND ADMINISTRATION PROCEDURE AND ADMINISTRATION Definitions § 301.7701-2 Business entities; definitions. (a) Business entities. For purposes of this section and § 301.7701-3, a business entity is...

  20. 26 CFR 301.7701-2 - Business entities; definitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 18 2012-04-01 2012-04-01 false Business entities; definitions. 301.7701-2...) PROCEDURE AND ADMINISTRATION PROCEDURE AND ADMINISTRATION Definitions § 301.7701-2 Business entities; definitions. (a) Business entities. For purposes of this section and § 301.7701-3, a business entity is...

  1. 17 CFR Appendix A to Part 420 - Separate Reporting Entity

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Separate Reporting Entity A... Part 420—Separate Reporting Entity Subject to the following conditions, one or more aggregating entity(ies) (e.g., parent, subsidiary, or organizational component) in a reporting entity, either...

  2. Xanthogranulomatous Prostatitis, a Rare Prostatic Entity.

    PubMed

    Noyola, Alejandro; Gil, José Fernando; Lujano, Heriberto; Piñon, Omar; Muñoz, Gabriel; Michel, José Manuel; Garcia, Jorge; Valdez, Jorge; Morales, Omar

    2017-01-01

    There are several benign prostatic pathologies that can clinically mimic a prostate adenocarcinoma. Xanthogranulomatous prostatitis is a benign inflammatory condition of the prostate and a rare entity. A 47-year old male, with 3 years of lower urinary tract symptoms, with a palpable hypogastric tumor, digital rectal examination: solid prostate, of approximately 60 g. Initial PSA was 0.90 ng/mL. He underwent surgical excision of the lower abdominal nodule and prostatectomy. Histopathology showed xanthogranulomatous prostatitis, without malignancy. Xanthogranulomatous prostatitis is an extremely rare entity that can simulate prostate adenocarcinoma, therefore having a correct histopathological diagnosis is essential.

  3. Cross domains Arabic named entity recognition system

    NASA Astrophysics Data System (ADS)

    Al-Ahmari, S. Saad; Abdullatif Al-Johar, B.

    2016-07-01

    Named Entity Recognition (NER) plays an important role in many Natural Language Processing (NLP) applications such as; Information Extraction (IE), Question Answering (QA), Text Clustering, Text Summarization and Word Sense Disambiguation. This paper presents the development and implementation of domain independent system to recognize three types of Arabic named entities. The system works based on a set of domain independent grammar-rules along with Arabic part of speech tagger in addition to gazetteers and lists of trigger words. The experimental results shown, that the system performed as good as other systems with better results in some cases of cross-domains corpora.

  4. Annular lichenoid syphilis: A rare entity.

    PubMed

    Khurana, Ananta; Singal, Archana; Gupta, Seema

    2014-01-01

    Syphilis is a disease known for centuries, but still continues to be a diagnostic challenge as the myriad manifestations of secondary syphilis can mimic a lot many dermatological disorders. Lichenoid syphilis is an uncommon entity, reported only occasionally in the penicillin era. We present the case of a 32-year-old woman presenting with localized annular lichenoid lesions on the neck.

  5. 2 CFR 25.320 - Entity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Entity. 25.320 Section 25.320 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS PRE-AWARD RESPONSIBILITIES UNIVERSAL IDENTIFIER AND...

  6. 2 CFR 25.320 - Entity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Entity. 25.320 Section 25.320 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved UNIVERSAL IDENTIFIER AND CENTRAL...

  7. 2 CFR 25.320 - Entity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Entity. 25.320 Section 25.320 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS PRE-AWARD RESPONSIBILITIES UNIVERSAL IDENTIFIER AND...

  8. 31 CFR 536.303 - Entity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Entity. 536.303 Section 536.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY NARCOTICS TRAFFICKING SANCTIONS REGULATIONS General Definitions §...

  9. 31 CFR 536.303 - Entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 536.303 Section 536.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY NARCOTICS TRAFFICKING SANCTIONS REGULATIONS General Definitions §...

  10. 31 CFR 536.303 - Entity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Entity. 536.303 Section 536.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY NARCOTICS TRAFFICKING SANCTIONS REGULATIONS General Definitions §...

  11. 31 CFR 536.303 - Entity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Entity. 536.303 Section 536.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY NARCOTICS TRAFFICKING SANCTIONS REGULATIONS General Definitions §...

  12. 31 CFR 536.303 - Entity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Entity. 536.303 Section 536.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY NARCOTICS TRAFFICKING SANCTIONS REGULATIONS General Definitions §...

  13. 31 CFR 800.212 - Foreign entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Foreign entity. 800.212 Section 800.212 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF INVESTMENT SECURITY, DEPARTMENT OF THE TREASURY REGULATIONS PERTAINING TO MERGERS, ACQUISITIONS,...

  14. 31 CFR 510.303 - Entity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Entity. 510.303 Section 510.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY NORTH KOREA SANCTIONS REGULATIONS General Definitions § 510.303...

  15. 31 CFR 510.303 - Entity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Entity. 510.303 Section 510.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY NORTH KOREA SANCTIONS REGULATIONS General Definitions § 510.303...

  16. 31 CFR 510.303 - Entity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Entity. 510.303 Section 510.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY NORTH KOREA SANCTIONS REGULATIONS General Definitions § 510.303...

  17. 31 CFR 510.303 - Entity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Entity. 510.303 Section 510.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY NORTH KOREA SANCTIONS REGULATIONS General Definitions § 510.303...

  18. 31 CFR 587.303 - Entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 587.303 Section 587.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY FEDERAL REPUBLIC OF YUGOSLAVIA (SERBIA AND MONTENEGRO)...

  19. 47 CFR 22.882 - Designated entities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES Air...) Eligibility for small business provisions in the commercial Air-Ground Radiotelephone Service. (1) A small business is an entity that, together with its affiliates, its controlling interests and the affiliates...

  20. 2 CFR 25.320 - Entity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Entity. 25.320 Section 25.320 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Pre-award responsibilities UNIVERSAL IDENTIFIER AND...

  1. 31 CFR 558.303 - Entity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Entity. 558.303 Section 558.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY SOUTH SUDAN SANCTIONS REGULATIONS General Definitions § 558.303...

  2. 31 CFR 551.303 - Entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 551.303 Section 551.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY SOMALIA SANCTIONS REGULATIONS General Definitions § 551.303...

  3. 31 CFR 538.303 - Entity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Entity. 538.303 Section 538.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY SUDANESE SANCTIONS REGULATIONS General Definitions § 538.303...

  4. 31 CFR 588.303 - Entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 588.303 Section 588.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY WESTERN BALKANS STABILIZATION REGULATIONS General Definitions §...

  5. 31 CFR 541.303 - Entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 541.303 Section 541.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ZIMBABWE SANCTIONS REGULATIONS General Definitions § 541.303...

  6. 31 CFR 594.303 - Entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 594.303 Section 594.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY GLOBAL TERRORISM SANCTIONS REGULATIONS General Definitions §...

  7. 31 CFR 537.304 - Entity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Entity. 537.304 Section 537.304 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY BURMESE SANCTIONS REGULATIONS General Definitions § 537.304...

  8. 31 CFR 549.303 - Entity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Entity. 549.303 Section 549.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY LEBANON SANCTIONS REGULATIONS General Definitions § 549.303...

  9. 31 CFR 545.303 - Entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 545.303 Section 545.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY TALIBAN (AFGHANISTAN) SANCTIONS REGULATIONS General Definitions §...

  10. 31 CFR 541.303 - Entity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Entity. 541.303 Section 541.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ZIMBABWE SANCTIONS REGULATIONS General Definitions § 541.303...

  11. 31 CFR 551.303 - Entity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Entity. 551.303 Section 551.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY SOMALIA SANCTIONS REGULATIONS General Definitions § 551.303...

  12. 31 CFR 537.304 - Entity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Entity. 537.304 Section 537.304 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY BURMESE SANCTIONS REGULATIONS General Definitions § 537.304...

  13. 31 CFR 595.303 - Entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 595.303 Section 595.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY TERRORISM SANCTIONS REGULATIONS General Definitions § 595.303...

  14. 31 CFR 538.303 - Entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 538.303 Section 538.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY SUDANESE SANCTIONS REGULATIONS General Definitions § 538.303...

  15. 31 CFR 597.306 - Entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 597.306 Section 597.306 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY FOREIGN TERRORIST ORGANIZATIONS SANCTIONS REGULATIONS...

  16. 31 CFR 541.303 - Entity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Entity. 541.303 Section 541.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ZIMBABWE SANCTIONS REGULATIONS General Definitions § 541.303...

  17. 31 CFR 538.303 - Entity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Entity. 538.303 Section 538.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY SUDANESE SANCTIONS REGULATIONS General Definitions § 538.303...

  18. 31 CFR 551.303 - Entity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Entity. 551.303 Section 551.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY SOMALIA SANCTIONS REGULATIONS General Definitions § 551.303...

  19. 31 CFR 537.304 - Entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 537.304 Section 537.304 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY BURMESE SANCTIONS REGULATIONS General Definitions § 537.304...

  20. 31 CFR 549.303 - Entity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Entity. 549.303 Section 549.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY LEBANON SANCTIONS REGULATIONS General Definitions § 549.303...

  1. 47 CFR 27.1218 - Designated entities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... entrepreneur is an entity that, together with all attributed parties, has average gross revenues that are not... winning bid on any of the licenses in this subpart. (3) A winning bidder that qualifies as an entrepreneur, as defined in this section, or a consortium of entrepreneurs, may use a bidding credit of 15...

  2. 47 CFR 101.1429 - Designated entities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... for the preceding three years. (3) An entrepreneur is an entity that, together with its controlling... this chapter. A winning bidder that qualifies as an entrepreneur, as defined in this section, or a consortium of entrepreneurs may use the bidding credit specified in § 1.2110(f)(2)(iii) of this chapter....

  3. 47 CFR 27.702 - Designated entities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) Eligibility for small business provisions. (1) An entrepreneur is an entity that, together with its... credits. A winning bidder that qualifies as an entrepreneur, as defined in this section, or a consortium of entrepreneurs may use the bidding credit specified in § 1.2110(f)(2)(i) of this chapter. A...

  4. 42 CFR 425.104 - Legal entity.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Legal entity. 425.104 Section 425.104 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE... law, and authorized to conduct business in each State in which it operates for purposes of...

  5. 47 CFR 27.502 - Designated entities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Designated entities. 27.502 Section 27.502 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Competitive Bidding Procedures for the 698-806 MHz Band § 27.502 Designated...

  6. 47 CFR 27.1218 - Designated entities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 2 2012-10-01 2012-10-01 false Designated entities. 27.1218 Section 27.1218 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service § 27.1218 Designated...

  7. 47 CFR 27.502 - Designated entities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Designated entities. 27.502 Section 27.502 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Competitive Bidding Procedures for the 698-806 MHz Band § 27.502 Designated...

  8. 47 CFR 27.1218 - Designated entities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 2 2014-10-01 2014-10-01 false Designated entities. 27.1218 Section 27.1218 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service § 27.1218 Designated...

  9. 47 CFR 27.502 - Designated entities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 2 2012-10-01 2012-10-01 false Designated entities. 27.502 Section 27.502 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Competitive Bidding Procedures for the 698-806 MHz Band § 27.502 Designated...

  10. 47 CFR 27.1218 - Designated entities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Designated entities. 27.1218 Section 27.1218 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service § 27.1218 Designated...

  11. 47 CFR 27.1218 - Designated entities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Designated entities. 27.1218 Section 27.1218 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service § 27.1218 Designated...

  12. 78 FR 31822 - Unincorporated Business Entities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-28

    ... (System) institutions' use of unincorporated business entities (UBEs) organized under State law for certain business activities. A UBE includes limited partnerships (LPs), limited liability partnerships... 12 CFR Parts 604, 611, 612, 619, 620, 621, 622, 623, and 630 RIN 3052-AC65 Unincorporated...

  13. Leiomyosarcoma of the Penis, an Exceptional Entity

    PubMed Central

    Romero Gonzalez, Edwin Javier; Marenco Jiménez, José L.; Mayorga Pineda, Maria P.; Martínez Morán, Alfonso; Castiñeiras Fernández, Jesús

    2015-01-01

    In tumors of the penis, mesenchymal tumors are extremely rare and within them, sarcomas are exceptional. We report a patient with a sarcomatous lesion treated with conservative surgery with good surgical outcome and the review of the literature, to present the latest advances in the treatment of this unusual entity. PMID:26793502

  14. 31 CFR 596.308 - Person; entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Person; entity. 596.308 Section 596.308 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY TERRORISM LIST GOVERNMENTS SANCTIONS...

  15. 13 CFR 130.200 - Eligible entities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... or university; (3) A college or school of business, engineering, commerce or agriculture; (4) A... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Eligible entities. 130.200 Section 130.200 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS...

  16. 47 CFR 1.2110 - Designated entities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... small businesses, businesses owned by members of minority groups and/or women, and rural telephone... management committee; (B) The entity has authority to appoint, promote, demote, and fire senior executives... members of minority groups and/or women. Unless otherwise provided in rules governing specific services,...

  17. 47 CFR 1.2110 - Designated entities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... small businesses, businesses owned by members of minority groups and/or women, and rural telephone... management committee; (B) The entity has authority to appoint, promote, demote, and fire senior executives... members of minority groups and/or women. Unless otherwise provided in rules governing specific services,...

  18. 31 CFR 543.304 - Entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 543.304 Section 543.304 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CôTE D'IVOIRE SANCTIONS REGULATIONS General Definitions §...

  19. 31 CFR 592.303 - Entity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Entity. 592.303 Section 592.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ROUGH DIAMONDS CONTROL REGULATIONS General Definitions §...

  20. 31 CFR 592.303 - Entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 592.303 Section 592.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ROUGH DIAMONDS CONTROL REGULATIONS General Definitions §...

  1. 31 CFR 592.303 - Entity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Entity. 592.303 Section 592.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ROUGH DIAMONDS CONTROL REGULATIONS General Definitions §...

  2. 31 CFR 592.303 - Entity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Entity. 592.303 Section 592.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ROUGH DIAMONDS CONTROL REGULATIONS General Definitions §...

  3. 31 CFR 592.303 - Entity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Entity. 592.303 Section 592.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ROUGH DIAMONDS CONTROL REGULATIONS General Definitions §...

  4. Annular lichenoid syphilis: A rare entity

    PubMed Central

    Khurana, Ananta; Singal, Archana; Gupta, Seema

    2014-01-01

    Syphilis is a disease known for centuries, but still continues to be a diagnostic challenge as the myriad manifestations of secondary syphilis can mimic a lot many dermatological disorders. Lichenoid syphilis is an uncommon entity, reported only occasionally in the penicillin era. We present the case of a 32-year-old woman presenting with localized annular lichenoid lesions on the neck. PMID:26396452

  5. 31 CFR 586.303 - Entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 586.303 Section 586.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY FEDERAL REPUBLIC OF YUGOSLAVIA (SERBIA & MONTENEGRO) KOSOVO...

  6. 31 CFR 548.303 - Entity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Entity. 548.303 Section 548.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY BELARUS SANCTIONS REGULATIONS General Definitions § 548.303...

  7. 31 CFR 548.303 - Entity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Entity. 548.303 Section 548.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY BELARUS SANCTIONS REGULATIONS General Definitions § 548.303...

  8. 31 CFR 548.303 - Entity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Entity. 548.303 Section 548.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY BELARUS SANCTIONS REGULATIONS General Definitions § 548.303...

  9. 31 CFR 548.303 - Entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 548.303 Section 548.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY BELARUS SANCTIONS REGULATIONS General Definitions § 548.303...

  10. 31 CFR 548.303 - Entity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Entity. 548.303 Section 548.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY BELARUS SANCTIONS REGULATIONS General Definitions § 548.303...

  11. 31 CFR 593.303 - Entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 593.303 Section 593.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY FORMER LIBERIAN REGIME OF CHARLES TAYLOR SANCTIONS REGULATIONS...

  12. 31 CFR 562.303 - Entity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Entity. 562.303 Section 562.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY IRANIAN HUMAN RIGHTS ABUSES SANCTIONS REGULATIONS General...

  13. 31 CFR 562.303 - Entity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Entity. 562.303 Section 562.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY IRANIAN HUMAN RIGHTS ABUSES SANCTIONS REGULATIONS General...

  14. 31 CFR 562.303 - Entity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Entity. 562.303 Section 562.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY IRANIAN HUMAN RIGHTS ABUSES SANCTIONS REGULATIONS General...

  15. 31 CFR 562.303 - Entity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Entity. 562.303 Section 562.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY IRANIAN HUMAN RIGHTS ABUSES SANCTIONS REGULATIONS General...

  16. 31 CFR 551.303 - Entity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Entity. 551.303 Section 551.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY SOMALIA SANCTIONS REGULATIONS General Definitions § 551.303...

  17. 31 CFR 551.303 - Entity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Entity. 551.303 Section 551.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY SOMALIA SANCTIONS REGULATIONS General Definitions § 551.303...

  18. Ada Compiler Validation Summary Report. Certificate Number: 880715S1. 09153. InterACT Corporation, InterACT Ada 1750A Compiler System, Release 3.0 VAX 11/785 Host, Fairchild F9450/1750A Target

    DTIC Science & Technology

    1988-07-15

    Programming language, Ada Compiler Validation Summary Report, Ada Compiler Validation Capability, ACVC, Validation Testing, Ada Validation Office, AVO ...the Ada Validation Organization ( AVO ). On-site testing was completed on 16 July 1988 at InterACT Corporation, New York, New York. 1.2 USE OF TIS...VAL1ITION SUMZMY REPOFG Consistent with the national laws of the originating country, the AVO may make full and free public disclosure of this report. In

  19. Privacy Act

    EPA Pesticide Factsheets

    Learn about the Privacy Act of 1974, the Electronic Government Act of 2002, the Federal Information Security Management Act, and other information about the Environmental Protection Agency maintains its records.

  20. 26 CFR 301.7701-3 - Classification of certain business entities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... may also make an election to change the classification of the target corporation. If a taxpayer makes... 26 Internal Revenue 18 2011-04-01 2011-04-01 false Classification of certain business entities... (CONTINUED) PROCEDURE AND ADMINISTRATION PROCEDURE AND ADMINISTRATION Definitions § 301.7701-3...

  1. 26 CFR 301.7701-3 - Classification of certain business entities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... members' liability that occurs at any time during the time that the entity's classification is relevant as... classification was relevant (as defined in paragraph (d) of this section) at any time during the sixty months... may also make an election to change the classification of the target corporation. If a taxpayer...

  2. 26 CFR 301.7701-3 - Classification of certain business entities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... members' liability that occurs at any time during the time that the entity's classification is relevant as... classification was relevant (as defined in paragraph (d) of this section) at any time during the sixty months... may also make an election to change the classification of the target corporation. If a taxpayer...

  3. 26 CFR 301.7701-3 - Classification of certain business entities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... members' liability that occurs at any time during the time that the entity's classification is relevant as... classification was relevant (as defined in paragraph (d) of this section) at any time during the sixty months... may also make an election to change the classification of the target corporation. If a taxpayer...

  4. Microwave assisted total synthesis of a benzothiophene-based new chemical entity (NCE)

    EPA Science Inventory

    Pharmaceutical scientists are required to generate diverse arrays of complex targets in short span of time, which can now be achieved by microwave-assisted organic synthesis. New chemical entities (NCE) can be built in a fraction of the time using this technique. However, there a...

  5. Using nanoinformatics methods for automatically identifying relevant nanotoxicology entities from the literature.

    PubMed

    García-Remesal, Miguel; García-Ruiz, Alejandro; Pérez-Rey, David; de la Iglesia, Diana; Maojo, Víctor

    2013-01-01

    Nanoinformatics is an emerging research field that uses informatics techniques to collect, process, store, and retrieve data, information, and knowledge on nanoparticles, nanomaterials, and nanodevices and their potential applications in health care. In this paper, we have focused on the solutions that nanoinformatics can provide to facilitate nanotoxicology research. For this, we have taken a computational approach to automatically recognize and extract nanotoxicology-related entities from the scientific literature. The desired entities belong to four different categories: nanoparticles, routes of exposure, toxic effects, and targets. The entity recognizer was trained using a corpus that we specifically created for this purpose and was validated by two nanomedicine/nanotoxicology experts. We evaluated the performance of our entity recognizer using 10-fold cross-validation. The precisions range from 87.6% (targets) to 93.0% (routes of exposure), while recall values range from 82.6% (routes of exposure) to 87.4% (toxic effects). These results prove the feasibility of using computational approaches to reliably perform different named entity recognition (NER)-dependent tasks, such as for instance augmented reading or semantic searches. This research is a "proof of concept" that can be expanded to stimulate further developments that could assist researchers in managing data, information, and knowledge at the nanolevel, thus accelerating research in nanomedicine.

  6. Using Nanoinformatics Methods for Automatically Identifying Relevant Nanotoxicology Entities from the Literature

    PubMed Central

    García-Remesal, Miguel; García-Ruiz, Alejandro; Pérez-Rey, David; de la Iglesia, Diana; Maojo, Víctor

    2013-01-01

    Nanoinformatics is an emerging research field that uses informatics techniques to collect, process, store, and retrieve data, information, and knowledge on nanoparticles, nanomaterials, and nanodevices and their potential applications in health care. In this paper, we have focused on the solutions that nanoinformatics can provide to facilitate nanotoxicology research. For this, we have taken a computational approach to automatically recognize and extract nanotoxicology-related entities from the scientific literature. The desired entities belong to four different categories: nanoparticles, routes of exposure, toxic effects, and targets. The entity recognizer was trained using a corpus that we specifically created for this purpose and was validated by two nanomedicine/nanotoxicology experts. We evaluated the performance of our entity recognizer using 10-fold cross-validation. The precisions range from 87.6% (targets) to 93.0% (routes of exposure), while recall values range from 82.6% (routes of exposure) to 87.4% (toxic effects). These results prove the feasibility of using computational approaches to reliably perform different named entity recognition (NER)-dependent tasks, such as for instance augmented reading or semantic searches. This research is a “proof of concept” that can be expanded to stimulate further developments that could assist researchers in managing data, information, and knowledge at the nanolevel, thus accelerating research in nanomedicine. PMID:23509721

  7. Synthesis and pharmacological evaluation of dual acting ligands targeting the adenosine A2A and dopamine D2 receptors for the potential treatment of Parkinson's disease.

    PubMed

    Jörg, Manuela; May, Lauren T; Mak, Frankie S; Lee, Kiew Ching K; Miller, Neil D; Scammells, Peter J; Capuano, Ben

    2015-01-22

    A relatively new strategy in drug discovery is the development of dual acting ligands. These molecules are potentially able to interact at two orthosteric binding sites of a heterodimer simultaneously, possibly resulting in enhanced subtype selectivity, higher affinity, enhanced or modified physiological response, and reduced reliance on multiple drug administration regimens. In this study, we have successfully synthesized a series of classical heterobivalent ligands as well as a series of more integrated and "drug-like" dual acting molecules, incorporating ropinirole as a dopamine D2 receptor agonist and ZM 241385 as an adenosine A2A receptor antagonist. The best compounds of our series maintained the potency of the original pharmacophores at both receptors (adenosine A2A and dopamine D2). In addition, the integrated dual acting ligands also showed promising results in preliminary blood-brain barrier permeability tests, whereas the classical heterobivalent ligands are potentially more suited as pharmacological tools.

  8. Customer and household matching: resolving entity identity in data warehouses

    NASA Astrophysics Data System (ADS)

    Berndt, Donald J.; Satterfield, Ronald K.

    2000-04-01

    The data preparation and cleansing tasks necessary to ensure high quality data are among the most difficult challenges faced in data warehousing and data mining projects. The extraction of source data, transformation into new forms, and loading into a data warehouse environment are all time consuming tasks that can be supported by methodologies and tools. This paper focuses on the problem of record linkage or entity matching, tasks that can be very important in providing high quality data. Merging two or more large databases into a single integrated system is a difficult problem in many industries, especially in the wake of acquisitions. For example, managing customer lists can be challenging when duplicate entries, data entry problems, and changing information conspire to make data quality an elusive target. Common tasks with regard to customer lists include customer matching to reduce duplicate entries and household matching to group customers. These often O(n2) problems can consume significant resources, both in computing infrastructure and human oversight, and the goal of high accuracy in the final integrated database can be difficult to assure. This paper distinguishes between attribute corruption and entity corruption, discussing the various impacts on quality. A metajoin operator is proposed and used to organize past and current entity matching techniques. Finally, a logistic regression approach to implementing the metajoin operator is discussed and illustrated with an example. The metajoin can be used to determine whether two records match, don't match, or require further evaluation by human experts. Properly implemented, the metajoin operator could allow the integration of individual databases with greater accuracy and lower cost.

  9. 22 CFR 96.5 - Requirement that accrediting entity be a nonprofit or public entity.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... section 501(c)(3) of the Internal Revenue Code of 1986, as amended, that has expertise in developing and... agencies in a State and that has expertise in developing and administering standards for entities...

  10. Native Hawaiian Education Act: Greater Oversight Would Increase Accountability and Enable Targeting of Funds to Areas with Greatest Need. Report to Congressional Requesters. GAO-08-422

    ERIC Educational Resources Information Center

    Government Accountability Office, 2008

    2008-01-01

    The Native Hawaiian Education Act (NHEA) seeks to develop innovative educational programs to assist Native Hawaiians. The Department of Education (Education) administers NHEA and has provided grants for a wide range of activities. Education is authorized to establish a Native Hawaiian Education Council and seven island councils to help implement…

  11. BRG1 and BRM chromatin-remodeling complexes regulate the hypoxia response by acting as coactivators for a subset of hypoxia-inducible transcription factor target genes.

    PubMed

    Sena, Johnny A; Wang, Liyi; Hu, Cheng-Jun

    2013-10-01

    Chromatin remodeling is an active process, which represses or enables the access of transcription machinery to genes in response to external stimuli, including hypoxia. However, in hypoxia, the specific requirement, as well as the molecular mechanism by which the chromatin-remodeling complexes regulate gene expression, remains unclear. In this study, we report that the Brahma (BRM) and Brahma-related gene 1 (BRG1) ATPase-containing SWI/SNF chromatin-remodeling complexes promote the expression of the hypoxia-inducible transcription factor 1α (HIF1α) and HIF2α genes and also promote hypoxic induction of a subset of HIF1 and HIF2 target genes. We show that BRG1 or BRM knockdown in Hep3B and RCC4T cells reduces hypoxic induction of HIF target genes, while reexpression of BRG1 or BRM in BRG1/BRM-deficient SW13 cells increases HIF target gene activation. Mechanistically, HIF1 and HIF2 increase the hypoxic induction of HIF target genes by recruiting BRG1 complexes to HIF target gene promoters, which promotes nucleosome remodeling of HIF target gene promoters in a BRG1 ATPase-dependent manner. Importantly, we found that the function of BRG1 complexes in hypoxic SW13 and RCC4T cells is dictated by the HIF-mediated hypoxia response and could be opposite from their function in normoxic SW13 and RCC4T cells.

  12. 7 CFR 63.4 - Eligible entity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) NATIONAL SHEEP INDUSTRY... promotes the betterment of the United States sheep or goat industries and that is a public, private,...

  13. 7 CFR 63.4 - Eligible entity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) NATIONAL SHEEP INDUSTRY... promotes the betterment of the United States sheep or goat industries and that is a public, private,...

  14. 7 CFR 63.4 - Eligible entity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) NATIONAL SHEEP INDUSTRY... promotes the betterment of the United States sheep or goat industries and that is a public, private,...

  15. 7 CFR 63.4 - Eligible entity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) NATIONAL SHEEP INDUSTRY... promotes the betterment of the United States sheep or goat industries and that is a public, private,...

  16. Software Engineering Support Activities for Very Small Entities

    NASA Astrophysics Data System (ADS)

    Ribaud, Vincent; Saliou, Philippe; O'Connor, Rory V.; Laporte, Claude Y.

    The emerging ISO/IEC 29110 standard Lifecycle profiles for Very Small Entities has at its core a Management and Engineering Guides which is targeted at very small entity (enterprise, organization, department or project) having up to 25 people, to assist them unlock the potential benefits of using standards which are specifically designed to address there needs. The developers of the standard, ISO/IEC JCT1/SC7 Working Group 24 (WG24), recommend the use of pilot projects as a mean to trial the adoption of the new International standard in small organisations. Accordingly an ISO/IEC 29110 pilot project has been established between the Software Engineering group of Brest University and a 14 person company with the aim of establishing an engineering discipline for a new web-based project. This paper details the lessons learned from the pilot project and based on our experiences with using ISO/IEC 29110 we identify a potential deficiency and accordingly propose new process area, "Infrastructure and Support" for include in the future evolution of ISO/IEC 29110 Process Profiles.

  17. The preclinical testing strategy for the development of novel chemical entities for the treatment of asthma.

    PubMed

    Hahn, Christian; Erb, Klaus Joseph

    2008-06-01

    Identifying and developing novel chemical entities (NCE) for the treatment of asthma is a time-consuming process and liabilities that endanger the successful progression of a compound from research into the patient are found throughout all phases of drug discovery. In particular the failure of advanced compounds in clinical studies due to lack of efficacy and/or safety concerns is tremendously costly. Therefore, in order to try and reduce the failure rate in clinical trials various in vitro and in vivo tests are performed during preclinical development, to rapidly identify liabilities, eliminate high risk compounds and promote promising potential drug candidates. To achieve this objective, numerous prerequisites have to be met regarding the physico-chemical properties of the compound, and bioactivity or model systems are needed to rate the therapeutic potential of new compounds. Drug liabilities such as target and species specificity, formulation issues, pharmacokinetics as well as pharmacodynamics and the toxic potential of the compound have to be analyzed in great detail before a compound can enter a clinical trial. A particularly challenging aspect of developing novel NCEs for the treatment of asthma is choosing and setting up in vivo models believed to be predictive for human disease. Numerous companies have in the past and are currently developing NCEs targeting many different pathways and cells with the aim to treat asthma. However, currently the only NCE having a significant market share are long-acting beta-agonists (LABA), inhaled and orally active steroids and leukotriene receptor antagonists. In the past many novel NCE for the treatment of asthma were effective in animal models but failed in the clinic. In this review we outline the prerequisites of novel NCE needed for clinical development.

  18. On Carcinomas and Other Pathological Entities

    PubMed Central

    Kumar, Anand; Ceusters, Werner; Rosse, Cornelius

    2005-01-01

    Tumours, abscesses, cysts, scars and fractures are familiar types of what we shall call pathological continuant entities. The instances of such types exist always in or on anatomical structures, which thereby become transformed into pathological anatomical structures of corresponding types: a fractured tibia, a blistered thumb, a carcinomatous colon. In previous work on biomedical ontologies we showed how the provision of formal definitions for relations such as is_a, part_of and transformation_of can facilitate the integration of such ontologies in ways which have the potential to support new kinds of automated reasoning. We here extend this approach to the treatment of pathologies, focusing especially on those pathological continuant entities which arise when organs become affected by carcinomas. PMID:18629199

  19. 14 CFR 252.19 - Single-entity charters.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) ECONOMIC REGULATIONS SMOKING ABOARD AIRCRAFT § 252.19 Single-entity charters. On single-entity charters... flights is given notice of the smoking procedures for the flight at the time he or she first...

  20. 14 CFR 252.19 - Single-entity charters.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) ECONOMIC REGULATIONS SMOKING ABOARD AIRCRAFT § 252.19 Single-entity charters. On single-entity charters... flights is given notice of the smoking procedures for the flight at the time he or she first...

  1. 14 CFR 252.19 - Single-entity charters.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...) ECONOMIC REGULATIONS SMOKING ABOARD AIRCRAFT § 252.19 Single-entity charters. On single-entity charters... flights is given notice of the smoking procedures for the flight at the time he or she first...

  2. 14 CFR 252.19 - Single-entity charters.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...) ECONOMIC REGULATIONS SMOKING ABOARD AIRCRAFT § 252.19 Single-entity charters. On single-entity charters... flights is given notice of the smoking procedures for the flight at the time he or she first...

  3. 14 CFR 252.19 - Single-entity charters.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...) ECONOMIC REGULATIONS SMOKING ABOARD AIRCRAFT § 252.19 Single-entity charters. On single-entity charters... flights is given notice of the smoking procedures for the flight at the time he or she first...

  4. 26 CFR 301.7701-2 - Business entities; definitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... El Salvador, Sociedad Anonima Estonia, Aktsiaselts European Economic Area/European Union, Societas... interest in the entity. The reference to the European Economic Area/European Union entity in paragraph...

  5. 26 CFR 301.7701-2 - Business entities; definitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... El Salvador, Sociedad Anonima Estonia, Aktsiaselts European Economic Area/European Union, Societas... interest in the entity. The reference to the European Economic Area/European Union entity in paragraph...

  6. [In vivo imaging for biodistribution and metabolism evaluations of new chemical entities].

    PubMed

    Corot, C; Idée, J-M; Raynaud, J-S; Salazar, J-F; Catoen, S

    2012-01-01

    Due to numerous technical developments, in vivo imaging is suitable for pharmacokinetic and metabolism studies of new chemical entities as well as for evaluating their pharmacological or biological effects. MRI, nuclear medicine, X-Ray, ultrasound and optical imaging are available for both clinical and experimental imaging with even higher performance. For all these imaging modalities, diagnostic agents are useful to improve contrast and specificity. Specific targeting of biological events is addressed by molecular imaging. From a pharmacodynamic perspective, radiolabeling of a new chemical entity allows in vivo visualization quantitative measure of its biodistribution, its elimination and its specific molecular binding. Non-invasive imaging methods are useful for longitudinal investigations of biological changes. Based on nanotechnologies, specificity of drug delivery can be monitored by imaging. New developments in hybrid imaging technologies as well as multimodal contrast agents reinforce in vivo experimental and clinical proof of mechanism of new chemical entities.

  7. 45 CFR 160.310 - Responsibilities of covered entities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Responsibilities of covered entities. 160.310... Responsibilities of covered entities. (a) Provide records and compliance reports. A covered entity must keep such... information, including protected health information, that are pertinent to ascertaining compliance with...

  8. 45 CFR 160.310 - Responsibilities of covered entities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Responsibilities of covered entities. 160.310... Responsibilities of covered entities. (a) Provide records and compliance reports. A covered entity must keep such... information, including protected health information, that are pertinent to ascertaining compliance with...

  9. 17 CFR 202.8 - Small entity compliance guides.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Small entity compliance guides... OTHER PROCEDURES § 202.8 Small entity compliance guides. The following small entity compliance guides...: Small Business and the SEC. 1 1 These items are also available on the Securities and Exchange...

  10. 31 CFR 535.301 - Iran; Iranian Entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Iran; Iranian Entity. 535.301 Section... § 535.301 Iran; Iranian Entity. (a) The term Iran and Iranian Entity includes: (1) The state and the Government of Iran as well as any political subdivision, agency, or instrumentality thereof or any...

  11. 31 CFR 535.301 - Iran; Iranian Entity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Iran; Iranian Entity. 535.301 Section... § 535.301 Iran; Iranian Entity. (a) The term Iran and Iranian Entity includes: (1) The state and the Government of Iran as well as any political subdivision, agency, or instrumentality thereof or any...

  12. 31 CFR 535.301 - Iran; Iranian Entity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Iran; Iranian Entity. 535.301 Section... § 535.301 Iran; Iranian Entity. (a) The term Iran and Iranian Entity includes: (1) The state and the Government of Iran as well as any political subdivision, agency, or instrumentality thereof or any...

  13. 31 CFR 535.301 - Iran; Iranian Entity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Iran; Iranian Entity. 535.301 Section... § 535.301 Iran; Iranian Entity. (a) The term Iran and Iranian Entity includes: (1) The state and the Government of Iran as well as any political subdivision, agency, or instrumentality thereof or any...

  14. 31 CFR 535.301 - Iran; Iranian Entity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Iran; Iranian Entity. 535.301 Section... § 535.301 Iran; Iranian Entity. (a) The term Iran and Iranian Entity includes: (1) The state and the Government of Iran as well as any political subdivision, agency, or instrumentality thereof or any...

  15. 37 CFR 253.2 - Definition of public broadcasting entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... broadcasting entity. 253.2 Section 253.2 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF... CONNECTION WITH NONCOMMERCIAL EDUCATIONAL BROADCASTING § 253.2 Definition of public broadcasting entity. As used in this part, the term public broadcasting entity means a noncommercial educational...

  16. 37 CFR 381.2 - Definition of public broadcasting entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... broadcasting entity. 381.2 Section 381.2 Patents, Trademarks, and Copyrights COPYRIGHT ROYALTY BOARD, LIBRARY... WITH NONCOMMERCIAL EDUCATIONAL BROADCASTING § 381.2 Definition of public broadcasting entity. As used in this part, the term public broadcasting entity means a noncommercial educational broadcast...

  17. 7 CFR 795.6 - Multiple individuals or other entities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Multiple individuals or other entities. 795.6 Section... Multiple individuals or other entities. The rules in §§ 795.5 through 795.16 shall be used to determine whether certain multiple individuals or legal entities are to be treated as one person or as...

  18. 78 FR 22270 - Special Fraud Alert: Physician-Owned Entities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ... HUMAN SERVICES Office of Inspector General Special Fraud Alert: Physician-Owned Entities AGENCY: Office... issued Special Fraud Alert on Physician-Owned Entities. Specifically, the Special Fraud Alert addressed... INFORMATION: In our publication of the Special Fraud Alert on Physician-Owned Entities, an inadvertent...

  19. 10 CFR 300.5 - Submission of an entity statement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Energy DEPARTMENT OF ENERGY CLIMATE CHANGE VOLUNTARY GREENHOUSE GAS REPORTING PROGRAM: GENERAL GUIDELINES... entity-wide emissions under the Climate Leaders or Climate VISION program. An entity that has made such a... start year, as long as the operations and boundaries of the entity have not changed significantly...

  20. 10 CFR 300.5 - Submission of an entity statement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Energy DEPARTMENT OF ENERGY CLIMATE CHANGE VOLUNTARY GREENHOUSE GAS REPORTING PROGRAM: GENERAL GUIDELINES... entity-wide emissions under the Climate Leaders or Climate VISION program. An entity that has made such a... start year, as long as the operations and boundaries of the entity have not changed significantly...

  1. 10 CFR 300.5 - Submission of an entity statement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Energy DEPARTMENT OF ENERGY CLIMATE CHANGE VOLUNTARY GREENHOUSE GAS REPORTING PROGRAM: GENERAL GUIDELINES... entity-wide emissions under the Climate Leaders or Climate VISION program. An entity that has made such a... start year, as long as the operations and boundaries of the entity have not changed significantly...

  2. 10 CFR 300.5 - Submission of an entity statement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Energy DEPARTMENT OF ENERGY CLIMATE CHANGE VOLUNTARY GREENHOUSE GAS REPORTING PROGRAM: GENERAL GUIDELINES... entity-wide emissions under the Climate Leaders or Climate VISION program. An entity that has made such a... start year, as long as the operations and boundaries of the entity have not changed significantly...

  3. 10 CFR 300.5 - Submission of an entity statement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Energy DEPARTMENT OF ENERGY CLIMATE CHANGE VOLUNTARY GREENHOUSE GAS REPORTING PROGRAM: GENERAL GUIDELINES... entity-wide emissions under the Climate Leaders or Climate VISION program. An entity that has made such a... start year, as long as the operations and boundaries of the entity have not changed significantly...

  4. 7 CFR 25.401 - Responsibility of lead managing entity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Responsibility of lead managing entity. 25.401 Section... COMMUNITIES Post-Designation Requirements § 25.401 Responsibility of lead managing entity. (a) Financial. The lead managing entity will be responsible for strategic plan program activities and monitoring...

  5. MicroRNA 603 acts as a tumor suppressor and inhibits triple-negative breast cancer tumorigenesis by targeting elongation factor 2 kinase.

    PubMed

    Bayraktar, Recep; Pichler, Martin; Kanlikilicer, Pinar; Ivan, Cristina; Bayraktar, Emine; Kahraman, Nermin; Aslan, Burcu; Oguztuzun, Serpil; Ulasli, Mustafa; Arslan, Ahmet; Calin, George; Lopez-Berestein, Gabriel; Ozpolat, Bulent

    2016-12-27

    Triple negative breast cancer (TNBC) is an aggressive type of breast cancer characterized by the absence of defined molecular targets, including estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and is associated with high rates of relapse and distant metastasis despite surgery and adjuvant chemotherapy. The lack of effective targeted therapies for TNBC represents an unmet therapeutic challenge. Eukaryotic elongation factor 2 kinase (eEF2K) is an atypical calcium/calmodulin-dependent serine/threonine kinase that promotes TNBC tumorigenesis, progression, and drug resistance, representing a potential novel molecular target. However, the mechanisms regulating eEF2K expression are unknown. Here, we report that eEF2K protein expression is highly up-regulated in TNBC cells and patient tumors and it is associated with poor patient survival and clinical outcome. We found that loss/reduced expression of miR-603 leads to eEF2K overexpression in TNBC cell lines. Its expression results in inhibition of eEF2K by directly targeting the 3-UTR and the inhibition of tumor cell growth, migration and invasion in TNBC. In vivo therapeutic gene delivery of miR-603 into TNBC xenograft mouse models by systemic administration of miR-603-nanoparticles led to a significant inhibition of eEF2K expression and tumor growth, which was associated with decreased activity of the downstream targets of eEF2K, including Src, Akt, cyclin D1 and c-myc. Our findings suggest that miR-603 functions as a tumor suppressor and loss of miR-603 expression leads to increase in eEF2K expression and contributes to the growth, invasion, and progression of TNBC. Taken together, our data suggest that miR-603-based gene therapy is a potential strategy against TNBC.

  6. Grepafloxacin, a dimethyl derivative of ciprofloxacin, acts preferentially through gyrase in Streptococcus pneumoniae: role of the C-5 group in target specificity.

    PubMed

    Morris, Julia E; Pan, Xiao-Su; Fisher, L Mark

    2002-02-01

    Grepafloxacin, a 5-methyl-7-piperazinyl-3"-methyl analogue of ciprofloxacin, was used to obtain stepwise-selected mutants of Streptococcus pneumoniae 7785. Analysis of the quinolone resistance-determining regions of the gyrA, gyrB, parC, and parE genes in these mutants revealed that gyrA mutations preceded those in parC. Given that ciprofloxacin (5-H,7-piperazinyl) and AM-1121 (5-H,7-piperazinyl-3"-methyl) both act through topoisomerase IV, we conclude that the 5-methyl group of grepafloxacin favors gyrase in S. pneumoniae.

  7. 76 FR 28503 - Identification of Three Entities as Government of Libya Entities Pursuant to Executive Order 13566

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-17

    ... Office of Foreign Assets Control Identification of Three Entities as Government of Libya Entities... Transactions Related to Libya.'' DATES: The identification by the Director of OFAC of the three entities... issued Executive Order 13566, ``Blocking Property and Prohibiting Certain Transactions Related to...

  8. 77 FR 24587 - Addition of Certain Persons to the Entity List; and Implementation of Entity List Annual Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ..., Egypt, Germany, Iran, Ireland, Israel, Kuwait, Lebanon, Norway, Russia, South Korea, Syria, the United..., Iran, Lebanon, Syria, and the U.A.E. sections of the Entity List. The Entity List provides notice to... review for entities listed under Armenia, Germany, Iran, Lebanon, South Korea, Syria, and the U.A.E....

  9. 20 CFR 670.300 - What entities are eligible to receive funds to operate centers and provide training and...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false What entities are eligible to receive funds to operate centers and provide training and operational support services? 670.300 Section 670.300... UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Funding and Selection of Service Providers § 670.300...

  10. 20 CFR 670.300 - What entities are eligible to receive funds to operate centers and provide training and...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What entities are eligible to receive funds to operate centers and provide training and operational support services? 670.300 Section 670.300... OF THE WORKFORCE INVESTMENT ACT Funding and Selection of Service Providers § 670.300 What...

  11. 76 FR 64427 - Designation of One Entity Pursuant to Executive Order 13224 of September 23, 2001, “Blocking...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... Commit, or Support Terrorism'' AGENCY: Office of Foreign Assets Control, Treasury. ACTION: Notice... Commit, or Support Terrorism.'' DATES: The designation by the Director of OFAC of the entity in this... emergency to address grave acts of terrorism and threats of terrorism committed by foreign...

  12. 77 FR 10806 - Designation of One Entity Pursuant to Executive Order 13224 of September 23, 2001, “Blocking...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-23

    ... Commit, or Support Terrorism'' AGENCY: Office of Foreign Assets Control, Treasury. ACTION: Notice... Commit, or Support Terrorism.'' DATES: The designation by the Director of OFAC of the entity in this... emergency to address grave acts of terrorism and threats of terrorism committed by foreign...

  13. 45 CFR 1159.5 - What government entities will the Endowment notify of proposed changes to its systems of records?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE ARTS IMPLEMENTATION OF THE PRIVACY ACT OF 1974 § 1159.5 What government entities will the... Affairs of the Senate, and the Office of Management and Budget (OMB), in order to permit an evaluation...

  14. 17 CFR 1.44 - Records and reports of warehouses, depositories, and other similar entities; visitation of premises.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... warehouses, depositories, and other similar entities; visitation of premises. 1.44 Section 1.44 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION GENERAL REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Miscellaneous § 1.44 Records and reports of warehouses, depositories, and other similar...

  15. 22 CFR 96.109 - Effect of the withdrawal of temporary accreditation by the accrediting entity or the Secretary.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Effect of the withdrawal of temporary accreditation by the accrediting entity or the Secretary. 96.109 Section 96.109 Foreign Relations DEPARTMENT OF STATE LEGAL AND RELATED SERVICES ACCREDITATION OF AGENCIES AND APPROVAL OF PERSONS UNDER THE INTERCOUNTRY ADOPTION ACT OF 2000 (IAA) Procedures...

  16. 20 CFR 661.210 - Under what circumstances may the Governor select an alternative entity in place of the State...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... LOCAL GOVERNANCE OF THE WORKFORCE INVESTMENT SYSTEM UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT State... unrepresented membership group, including entities carrying out One-stop partner programs, by means such as... considered to have occurred when additional members are added to an existing membership category, when...

  17. 78 FR 34706 - Designation of Two (2) Entities Pursuant to Executive Order 13628 of October 9, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    ... the Iran Threat Reduction and Syria Human Rights Act of 2012 and Additional Sanctions With Respect to Iran.'' DATES: The designations by the Director of OFAC of the two (2) entities identified in this..., ``Authorizing the Implementation of Certain Sanctions Set Forth in the Iran Threat Reduction and Syria...

  18. 20 CFR 670.430 - What entities conduct outreach and admissions activities for the Job Corps program?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false What entities conduct outreach and admissions activities for the Job Corps program? 670.430 Section 670.430 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) THE JOB CORPS UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Recruitment, Eligibility,...

  19. 20 CFR 670.430 - What entities conduct outreach and admissions activities for the Job Corps program?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false What entities conduct outreach and admissions activities for the Job Corps program? 670.430 Section 670.430 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) THE JOB CORPS UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Recruitment, Eligibility,...

  20. 20 CFR 670.430 - What entities conduct outreach and admissions activities for the Job Corps program?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What entities conduct outreach and admissions activities for the Job Corps program? 670.430 Section 670.430 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR THE JOB CORPS UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Recruitment, Eligibility, Screening,...

  1. Unstable solar lentigo: A defined separate entity.

    PubMed

    Byrom, Lisa; Barksdale, Sarah; Weedon, David; Muir, Jim

    2016-08-01

    An unstable solar lentigo is a solar lentigo with areas of melanocytic hyperplasia not extending past the margin of the lesion. They are discrete, macular, pigmented lesions arising on sun-damaged skin and a subset of typical solar lentigos. Clinically they differ from usual solar lentigines in often being solitary or larger and darker than adjacent solar lentigines. These lesions are of clinical importance as they can arise in close proximity to lentigo maligna and in a single lesion there can be demonstrated changes of solar lentigo, unstable solar lentigo and lentigo maligna. These observations led us to conjecture that unstable solar lentigos could be a precursor lesion to lentigo maligna. In this article we examine the possibility that lentigo maligna can arise within a solar lentigo through an intermediate lesion, the unstable solar lentigo. We propose that the histopathological recognition of this entity will allow for future research into its behaviour and thus management. We review difficulties in the diagnosis of single cell predominant melanocytic proliferations and the concept of unstable lentigo in view of the literature and clinical experience supporting the proposal of its recognition as a separate entity.

  2. Male urethral diverticulum uncommon entity: Our experience

    PubMed Central

    Thakur, Naveen; Sabale, Vilas Pandurang; Mane, Deepak; Mullay, Abhirudra

    2016-01-01

    Out pouching of the urethral wall could be congenital or acquired. Male urethral diverticulum (UD) is a rare entity. We present 2 cases of acquired and 1 case of congenital male UD. Case 1A: 40 year male presented with SPC and dribbling urine. Clinically he had hard perineal swelling. RGU revealed large diverticulum in proximal bulbar, irregular narrow distal urethra and stricture just beyond diverticulum. Managed with perineal exploration, stone removal, diverticulum repair and urethroplasty using excess diverticular wall. Case 2A: 30 year male with obstructive lower urinary tract symptoms (LUTS). Retrograde urethrogram (RGU) revealed bulbar urethral diverticulum akin to anterior urethral valve, managed endoscopically. 1 year follow up urine stream satisfactory. Case 3A: 27 year male previously operated large proximal bulbar urethral stone with incontinence. RGU large proximal bulbar UD with wide open sphincter. Treated with excision of excess diverticular wall and penile clamp with pelvic exercises for incontinence. Congenital UD develops due to imperfect closure of urethral fold, Acquired UDs occurs secondary to stricture, infection, trauma, long standing impacted urethral stones or scrotal / skin flap urethroplasties. RGU and MCU are the best diagnostic technique to confirm and characterize the UD. Urethral diverticulectomy with urethral reconstruction is the recommended treatment for UD. UD is a rare entity. Especially in males, congenital are even more rare. Management should be individualized. Surgery can involve innovation and/or surgical modifications. We used excess diverticular flap for stricture urethroplasty in one case. PMID:28057997

  3. Minimum information about a bioactive entity (MIABE).

    PubMed

    Orchard, Sandra; Al-Lazikani, Bissan; Bryant, Steve; Clark, Dominic; Calder, Elizabeth; Dix, Ian; Engkvist, Ola; Forster, Mark; Gaulton, Anna; Gilson, Michael; Glen, Robert; Grigorov, Martin; Hammond-Kosack, Kim; Harland, Lee; Hopkins, Andrew; Larminie, Christopher; Lynch, Nick; Mann, Romeena K; Murray-Rust, Peter; Lo Piparo, Elena; Southan, Christopher; Steinbeck, Christoph; Wishart, David; Hermjakob, Henning; Overington, John; Thornton, Janet

    2011-08-31

    Bioactive molecules such as drugs, pesticides and food additives are produced in large numbers by many commercial and academic groups around the world. Enormous quantities of data are generated on the biological properties and quality of these molecules. Access to such data - both on licensed and commercially available compounds, and also on those that fail during development - is crucial for understanding how improved molecules could be developed. For example, computational analysis of aggregated data on molecules that are investigated in drug discovery programmes has led to a greater understanding of the properties of successful drugs. However, the information required to perform these analyses is rarely published, and when it is made available it is often missing crucial data or is in a format that is inappropriate for efficient data-mining. Here, we propose a solution: the definition of reporting guidelines for bioactive entities - the Minimum Information About a Bioactive Entity (MIABE) - which has been developed by representatives of pharmaceutical companies, data resource providers and academic groups.

  4. Giant thoracic osteophyte: a distinct clinical entity.

    PubMed

    Coumans, Jean-Valery C E; Neal, Jonathan B; Grottkau, Brian E; Nahed, Brian V; Shin, John H; Walcott, Brian P

    2014-09-01

    Calcified lesions described within the neural axis are classified as either an ossification of the posterior longitudinal ligament, diffuse idiopathic skeletal hyperostosis, or ossification of the ligamentum flavum. We aim to describe a unique pathologic entity: the giant thoracic osteophyte. We identified four patients who were surgically treated at the Massachusetts General Hospital from 2006 to 2012 with unusual calcified lesions in the ventral aspect of the spinal canal. In order to differentiate giant thoracic osteophytes from calcified extruded disc material, disc volumetrics were performed on actual and simulated disc spaces. All patients underwent operative resection of the calcific lesion as they had signs and/or symptoms of spinal cord compression. The lesions were found to be isolated, large calcific masses that originated from the posterior aspect of adjacent thoracic vertebral bodies. Pathological examination was negative for tumor. Adjacent disc volumes were not significantly different from the index disc (p=0.91). A simulated calculation hypothesizing that the calcific mass was extruded disc material demonstrated a significant difference (p=0.01), making this scenario unlikely. In conclusion, giant thoracic osteophyte is a unique and rare entity that can be found in the thoracic spine. The central tenant of surgical treatment is resection to relieve spinal cord compression.

  5. Genome-Wide Characterization of cis-Acting DNA Targets Reveals the Transcriptional Regulatory Framework of Opaque2 in Maize[OPEN

    PubMed Central

    Li, Chaobin; Qiao, Zhenyi; Qi, Weiwei; Wang, Qian; Yuan, Yue; Yang, Xi; Tang, Yuanping; Mei, Bing; Lv, Yuanda; Zhao, Han; Xiao, Han; Song, Rentao

    2015-01-01

    Opaque2 (O2) is a transcription factor that plays important roles during maize endosperm development. Mutation of the O2 gene improves the nutritional value of maize seeds but also confers pleiotropic effects that result in reduced agronomic quality. To reveal the transcriptional regulatory framework of O2, we studied the transcriptome of o2 mutants using RNA sequencing (RNA-Seq) and determined O2 DNA binding targets using chromatin immunoprecipitation coupled to high-throughput sequencing (ChIP-Seq). The RNA-Seq analysis revealed 1605 differentially expressed genes (DEGs) and 383 differentially expressed long, noncoding RNAs. The DEGs cover a wide range of functions related to nutrient reservoir activity, nitrogen metabolism, stress resistance, etc. ChIP-Seq analysis detected 1686 O2 DNA binding sites distributed over 1143 genes. Overlay of the RNA-Seq and ChIP-Seq results revealed 35 O2-modulated target genes. We identified four O2 binding motifs; among them, TGACGTGG appears to be the most conserved and strongest. We confirmed that, except for the 16- and 18-kD zeins, O2 directly regulates expression of all other zeins. O2 directly regulates two transcription factors, genes linked to carbon and amino acid metabolism and abiotic stress resistance. We built a hierarchical regulatory model for O2 that provides an understanding of its pleiotropic biological effects. PMID:25691733

  6. miR-204-5p acts as a tumor suppressor by targeting matrix metalloproteinases-9 and B-cell lymphoma-2 in malignant melanoma

    PubMed Central

    Luan, Wenkang; Qian, Yao; Ni, Xin; Bu, Xuefeng; Xia, Yun; Wang, Jinlong; Ruan, Hongru; Ma, Shaojun; Xu, Bin

    2017-01-01

    An increasing number of microRNAs have been found to be involved in tumorigenesis, including melanoma tumorigenesis. miR-204-5p is down-regulated and functions as a tumor suppressor in many human malignant tumors. miR-204-5p expression is also decreased in melanoma tissues, but its biological roles and molecular mechanisms in malignant melanoma remain unclear. In this study, the aberrant down-regulation of miR-204-5p was detected in melanoma, especially in metastatic melanoma. miR-204-5p also served as a protective factor for the prognosis of melanoma patients. We determined that miR-204-5p suppresses cell proliferation, migration and invasion, and promotes cell apoptosis in melanoma. Matrix metalloproteinases-9 and B-cell lymphoma-2 are the functional targets of miR-204-5p, through which it plays an important biological role in malignant melanoma. The effect of miR-204-5p on malignant melanoma is verified using a xenograft model. We also determined that miR-204-5p increases 5-fluorouracil and cisplatin (DDP) chemosensitivity in malignant melanoma cells. This finding elucidates new functions and mechanisms for miR-204-5p in melanoma development, and provides potential therapeutic targets for the treatment of melanoma. PMID:28280358

  7. miR-28-5p acts as a tumor suppressor in renal cell carcinoma for multiple antitumor effects by targeting RAP1B

    PubMed Central

    Ding, Meng; Zhong, Jinsha; Zhang, Chen-Yu; Ge, Jingping; Wang, Junjun; Zhang, Chunni

    2016-01-01

    The incidence and mortality rate of renal cell carcinoma (RCC) have been significantly increasing; however, the mechanisms involved in RCC development and progression are unclear. In this study, we found that miR-28-5p was decreased in RCC tumor specimens and several renal carcinoma cell lines. By using a combination of luciferase reporter assays and western blotting, we identified RAP1B, a Ras-related small GTP-binding oncoprotein implicated in a variety of tumors, as a direct target of miR-28-5p in RCC. The RAP1B protein level was increased in RCC tumor specimens and renal carcinoma cell lines, and this was inversely correlated with miR-28-5p expression. In vitro gain-of-function and loss-of-function studies in human renal carcinoma cell lines, demonstrated that miR-28-5p suppressed cell proliferation and migration by directly inhibiting RAP1B, and this effect was reversed by co-transfection with RAP1B. In addition, the stable overexpression of miR-28-5p inhibited tumor cell proliferation in vivo. This newly identified miR-28-5p/RAP1B axis provides a novel mechanism for the pathogenesis of RCC, and molecules in this axis may serve as potential biomarkers and therapeutic targets for RCC. PMID:27729617

  8. High mobility group A1 protein acts as a new target of Notch1 signaling and regulates cell proliferation in T leukemia cells.

    PubMed

    Xi, Yang; Li, Yu-Sang; Tang, He-Bin

    2013-02-01

    Active mutations of Notch1 play pivotal roles during leukemogenesis, but the downstream targets and molecular mechanisms of activated Notch1 signaling have not yet been fully clarified. In this study, we detected the overexpression of the high mobility group A1 (HMGA1) and activation of Notch1 signaling in mouse thymic lymphomas. A direct regulation of Notch1 on HMGA1 transcription was demonstrated and two Notch1/RBPJ cobinding sites of T/CTCCCACA were found in HMGA1 promoter regions. It was the first time demonstrated that HMGA1 was the downstream target of Notch1 signaling. Moreover, knockdown of HMGA1 resulted in significantly impaired cell growth and decreased expressions of cyclin D and cyclin E in human T leukemia cells. The formation of complexes was also observed between HMGA1 and retinoblastoma (RB) protein indicating a mechanism of cell cycle regulation. These findings suggest that activated HMGA1 regulates cell proliferation through the Notch1 signaling pathway, which represents an important molecular pathway leading to leukemogenesis.

  9. 76 FR 43196 - Implementation of the Truth in Caller ID Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-20

    ...In this Report and Order (Order), the Commission adopts rules to implement the Truth in Caller ID Act of 2009 (Truth in Caller ID Act, or Act). The Truth in Caller ID Act, and the Commission's implementing rules, prohibit any person or entity from knowingly altering or manipulating caller identification information with the intent to defraud, cause harm, or wrongfully obtain anything of...

  10. MiR-361-5p acts as a tumor suppressor in prostate cancer by targeting signal transducer and activator of transcription-6(STAT6)

    SciTech Connect

    Liu, Dachuang; Tao, Tao; Xu, Bin; Chen, Shuqiu; Liu, Chunhui; Zhang, Lei; Lu, Kai; Huang, Yeqing; Jiang, Liang; Zhang, Xiaowen; Huang, Xiaoming; Zhang, Lihua; Han, Conghui; Chen, Ming

    2014-02-28

    Highlights: • The role of miR-361-5p in prostate cancer (PCa) has not been evaluated until date. • We found that the expression of miR-361-5p in CRPC was lower than in ADPC. • MiR-361-5p suppressed DU145 cell proliferation and triggered apoptosis. • STAT6 is a direct target of miR-361-5p. • STAT6 enhances the expression of Bcl-xL at the transcriptional level. - Abstract: Castration-resistant prostate cancer (CRPC), whose pathogenesis is known to be regulated by microRNAs (miRNAs), has a poor prognosis. In our present study, we found that the expression of miR-361-5p in CRPC was lower than in androgen-dependent prostate cancer (ADPC), indicating that miR-361-5p may play an important role in the progression of ADPC to CRPC. The role of miR-361-5p in prostate cancer (PCa) has not been evaluated until date. Our findings suggest that miR-361-5p is a suppressor in CRPC. Signal transducer and activator of transcription-6 (STAT6), a direct target of miR-361-5p, enhances the expression of B-cell lymphoma-extra large (Bcl-xL), while miR-361-5p inhibits its expression through STAT6. Therefore, miR-361-5p has great clinical significance in preventing the malignant progression of PCa.

  11. The Archipelago Ubiquitin Ligase Subunit Acts in Target Tissue to Restrict Tracheal Terminal Cell Branching and Hypoxic-Induced Gene Expression

    PubMed Central

    Mortimer, Nathan T.; Moberg, Kenneth H.

    2013-01-01

    The Drosophila melanogaster gene archipelago (ago) encodes the F-box/WD-repeat protein substrate specificity factor for an SCF (Skp/Cullin/F-box)-type polyubiquitin ligase that inhibits tumor-like growth by targeting proteins for degradation by the proteasome. The Ago protein is expressed widely in the fly embryo and larva and promotes degradation of pro-proliferative proteins in mitotically active cells. However the requirement for Ago in post-mitotic developmental processes remains largely unexplored. Here we show that Ago is an antagonist of the physiologic response to low oxygen (hypoxia). Reducing Ago activity in larval muscle cells elicits enhanced branching of nearby tracheal terminal cells in normoxia. This tracheogenic phenotype shows a genetic dependence on sima, which encodes the HIF-1α subunit of the hypoxia-inducible transcription factor dHIF and its target the FGF ligand branchless (bnl), and is enhanced by depletion of the Drosophila Von Hippel Lindau (dVHL) factor, which is a subunit of an oxygen-dependent ubiquitin ligase that degrades Sima/HIF-1α protein in metazoan cells. Genetic reduction of ago results in constitutive expression of some hypoxia-inducible genes in normoxia, increases the sensitivity of others to mild hypoxic stimulus, and enhances the ability of adult flies to recover from hypoxic stupor. As a molecular correlate to these genetic data, we find that Ago physically associates with Sima and restricts Sima levels in vivo. Collectively, these findings identify Ago as a required element of a circuit that suppresses the tracheogenic activity of larval muscle cells by antagonizing the Sima-mediated transcriptional response to hypoxia. PMID:23459416

  12. New orally active DNA minor groove binding small molecule CT-1 acts against breast cancer by targeting tumor DNA damage leading to p53-dependent apoptosis.

    PubMed

    Saini, Karan Singh; Hamidullah; Ashraf, Raghib; Mandalapu, Dhanaraju; Das, Sharmistha; Siddiqui, Mohd Quadir; Dwivedi, Sonam; Sarkar, Jayanta; Sharma, Vishnu Lal; Konwar, Rituraj

    2017-04-01

    Targeting tumor DNA damage and p53 pathway is a clinically established strategy in the development of cancer chemotherapeutics. Majority of anti-cancer drugs are delivered through parenteral route for reasons like severe toxicity, lack of stability, and poor enteral absorption. Current DNA targeting drugs in clinical like anthracycline suffers from major drawbacks like cardiotoxicity. Here, we report identification of a new orally active small molecule curcumin-triazole conjugate (CT-1) with significant anti-breast cancer activity in vitro and in vivo. CT-1 selectively and significantly inhibits viability of breast cancer cell lines; retards cells cycle progression at S phase and induce mitochondrial-mediated cell apoptosis. CT-1 selectively binds to minor groove of DNA and induces DNA damage leading to increase in p53 along with decrease in its ubiquitination. Inhibition of p53 with pharmacological inhibitor as well as siRNA revealed the necessity of p53 in CT-1-mediated anti-cancer effects in breast cancer cells. Studies using several other intact p53 and deficient p53 cancer cell lines further confirmed necessity of p53 in CT-1-mediated anti-cancer response. Pharmacological inhibition of pan-caspase showed CT-1 induces caspase-dependent cell death in breast cancer cells. Most interestingly, oral administration of CT-1 induces significant inhibition of tumor growth in LA-7 syngeneic orthotropic rat mammary tumor model. CT-1 treated mammary tumor shows enhancement in DNA damage, p53 upregulation, and apoptosis. Collectively, CT-1 exhibits potent anti-cancer effect both in vitro and in vivo and could serve as a safe orally active lead for anti-cancer drug development. © 2016 Wiley Periodicals, Inc.

  13. Encoding of Fundamental Chemical Entities of Organic Reactivity Interest using chemical ontology and XML.

    PubMed

    Durairaj, Vijayasarathi; Punnaivanam, Sankar

    2015-09-01

    Fundamental chemical entities are identified in the context of organic reactivity and classified as appropriate concept classes namely ElectronEntity, AtomEntity, AtomGroupEntity, FunctionalGroupEntity and MolecularEntity. The entity classes and their subclasses are organized into a chemical ontology named "ChemEnt" for the purpose of assertion, restriction and modification of properties through entity relations. Individual instances of entity classes are defined and encoded as a library of chemical entities in XML. The instances of entity classes are distinguished with a unique notation and identification values in order to map them with the ontology definitions. A model GUI named Entity Table is created to view graphical representations of all the entity instances. The detection of chemical entities in chemical structures is achieved through suitable algorithms. The possibility of asserting properties to the entities at different levels and the mechanism of property flow within the hierarchical entity levels is outlined.

  14. Cardiac Pseudoaneurysm- A Death Defying Entity

    PubMed Central

    Gupta, Saryu

    2016-01-01

    A pseudoaneurysm refers to a contained rupture of the myocardium with a tenuous pericardium walling off the leak. It needs to be differentiated from a true aneurysm by the fact that there is lack of myocardial tissue in the wall of a pseudoaneurysm. The differentiation between the two is pertinent as true aneurysms can be treated medically while pseudoaneurysms require urgent surgical treatment. Untreated pseudoaneurysms carry a high risk of rupture and mortality. We report a case of cardiac pseudoaneurysm developing in a 46-year-old male who had suffered myocardial infarction four months back. The patient now presented with chest pain and dyspnoea. CECT chest revealed a partially thrombosed large pseudoaneurysm arising from the posterior wall of left ventricle. While the clinical diagnosis of this entity is difficult, CECT plays a pivotal role in the non-invasive detection of pseudoaneurysms. PMID:27504379

  15. A Closer Look: The American Taxpayer Relief Act of 2012

    ERIC Educational Resources Information Center

    Balmer, Mary

    2013-01-01

    School districts may be affected by the American Taxpayer Relief Act of 2012 with regard to fixed assets management and education entities. The act avoids the scheduled increases to individual income tax rates for most Americans and extends a host of expired and expiring tax provisions for both individuals and businesses. The provisions described…

  16. Adoptive therapy with CAR redirected T cells: the challenges in targeting solid tumors.

    PubMed

    Abken, Hinrich

    2015-01-01

    Recent spectacular success in the adoptive cell therapy of leukemia and lymphoma with chimeric antigen receptor (CAR)-modified T cells raised the expectations that this therapy may be efficacious in a wide range of cancer entities. The expectations are based on the predefined specificity of CAR T cells by an antibody-derived binding domain that acts independently of the natural T-cell receptor, recognizes targets independently of presentation by the major histocompatibility complex and allows targeting toward virtually any cell surface antigen. We here discuss that targeting CAR T cells toward solid tumors faces certain circumstances critical for the therapeutic success. Targeting tumor stroma and taking advantage of TRUCK cells, in other words, CAR T cells with inducible release of a transgenic payload, are some strategies envisaged to overcome current limitations in the near future.

  17. [Gastric signet ring cell adenocarcinoma: A distinct entity].

    PubMed

    Tabouret, Tessa; Dhooge, Marion; Rouquette, Alexandre; Brezault, Catherine; Beuvon, Frédéric; Chaussade, Stanislas; Coriat, Romain

    2014-04-01

    Gastric signet ring cell carcinoma (GSRC) is a distinct entity. Their incidence is increasing. The pathologist plays a central role in the identification of this entity. Diagnosis is based on an adenocarcinoma containing a majority of signet ring cells (above 50 %). The prognosis of GSRC is the same as gastric adenocarcinoma while GSRC appeared more aggressive. Signet ring cells present a low sensitivity to chemotherapy. This review aimed to discuss the histological, the prognostic and the therapeutic aspect of this entity.

  18. Engineered Nanomedicine with Alendronic Acid Corona Improves Targeting to Osteosarcoma

    PubMed Central

    Nguyen, Tuyen Duong Thanh; Pitchaimani, Arunkumar; Aryal, Santosh

    2016-01-01

    We engineered nanomedicine with the stealth corona made up of densely packed bone seeking ligand, alendronic acid. In a typical nanoconstruct, alendronic acid is conjugated with hydrophilic head moiety of phospholipid that has an ability to self-assemble with hydrophobic polymeric core through its hydrophobic long carbon-chain. Proposed nanomedicine has three distinct compartments namely; poly(l-lactic-co-glycolic acid) polymeric core acting as a drug reservoir and skeleton of the nanoconstruct, phospholipid monolayer covers the core acting as a diffusion barrier, and a densely packed alendronic acid corona acting as a stabilizer and targeting moiety. Thus engineered nanomedicine attain spherical entity with ~90 ± 6 nm having negative zeta potential, −37.7 ± 2 mV, and has an ability to load 7 ± 0.3 wt% of doxorubicin. In-vitro bone targeting efficiency of nanomedicine was studied using hydroxyapatite crystals as a bone model, and found significant accumulation of nanoparticle in the crystals. Moreover, cellular internalization studies with mouse osteosarcoma confirm the selectivity of nanomedicine when compared to its internalization in non-targeted mouse melanoma. This nanomedicine shows prolong stability in serum and deliver the drug into the cell exhibiting an IC50 of 3.7 μM. Given the strong interacting property of alendronic acid with bone, the proposed nanomedicine hold promises in delivering drug to bone microenvironment. PMID:27824143

  19. Neverland regulates embryonic moltings through the regulation of ecdysteroid synthesis in the water flea Daphnia magna, and may thus act as a target for chemical disruption of molting.

    PubMed

    Sumiya, Eri; Ogino, Yukiko; Toyota, Kenji; Miyakawa, Hitoshi; Miyagawa, Shinichi; Iguchi, Taisen

    2016-11-01

    Embryo development in arthropods is accompanied by a series of moltings. A cladoceran crustacean Daphnia magna molts three times before reaching first instar neonate during embryogenesis. Previous studies argued ecdysteroids might regulate D. magna embryogenesis. However, no direct evidence between innate ecdysteroids fluctuation and functions has been forthcoming. Recently, we identified genes involved in ecdysteroid synthesis called, neverland (neverland1 and neverland 2) and shade and in the ecdysteroid degradation (Cyp18a1). To understand the physiological roles of ecdysteroids in D. magna embryos, we performed expression and functional analyzes of those genes. Examining innate ecdysteroids titer during embryogenesis showed two surges of ecdysteroids titer at 41 and 61 h after oviposition. The first and second embryonic moltings occurred at each ecdysteroid surge. Expression of neverland1 and shade began to increase before the first peak in ecdysteroid. Knockdown of neverland1 or shade by RNAi technique caused defects in embryonic moltings and subsequent development. The ecdysteroids titer seemingly decreased in nvd1-knowckdown embryos. Knockdown of Cyp18a1 resulted in early embryonic lethality before the first molting. Our in situ hybridization analysis revealed that nvd1 was prominently expressed in embryonic gut epithelium suggesting the site for an initial step of ecdysteroidgenesis, a conversion of cholesterol to 7-dehydrocholesterol and possibly for ecdysone production. Taken together, de novo ecdysteroid synthesis by nvd1 in the gut epithelial cells stimulates molting, which is indispensable for D. magna embryo development. These findings identify neverland as a possible target for chemicals, including various pesticides that are known to disrupt molting, development and reproduction. Copyright © 2016 John Wiley & Sons, Ltd.

  20. Lipid rafts and raft-mediated supramolecular entities in the regulation of CD95 death receptor apoptotic signaling.

    PubMed

    Gajate, Consuelo; Mollinedo, Faustino

    2015-05-01

    Membrane lipid rafts are highly ordered membrane domains enriched in cholesterol, sphingolipids and gangliosides that have the property to segregate and concentrate proteins. Lipid and protein composition of lipid rafts differs from that of the surrounding membrane, thus providing sorting platforms and hubs for signal transduction molecules, including CD95 death receptor-mediated signaling. CD95 can be recruited to rafts in a reversible way through S-palmitoylation following activation of cells with its physiological cognate ligand as well as with a wide variety of inducers, including several antitumor drugs through ligand-independent intracellular mechanisms. CD95 translocation to rafts can be modulated pharmacologically, thus becoming a target for the treatment of apoptosis-defective diseases, such as cancer. CD95-mediated signaling largely depends on protein-protein interactions, and the recruitment and concentration of CD95 and distinct downstream apoptotic molecules in membrane raft domains, forming raft-based supramolecular entities that act as hubs for apoptotic signaling molecules, favors the generation and amplification of apoptotic signals. Efficient CD95-mediated apoptosis involves CD95 and raft internalization, as well as the involvement of different subcellular organelles. In this review, we briefly summarize and discuss the involvement of lipid rafts in the regulation of CD95-mediated apoptosis that may provide a new avenue for cancer therapy.

  1. Delft University at the TREC 2009 Entity Track: Ranking Wikipedia Entities

    DTIC Science & Technology

    2009-11-01

    containing ClueWeb09 collection using Lemur Toolkit 4.10. We used no stemming and stop-word removal on the collection level. However, we applied a very...approach implemented in Lemur with Dirichlet smoothing (µ = 1500). In order to have some flexibility in development and also for the sake of better...consider them as the only entities allowed (actu- ally, using #scoreif directive of the Lemur query language). Since we still could not be sure that all

  2. Rad6B acts downstream of Wnt signaling to stabilize β-catenin: Implications for a novel Wnt/β-catenin target

    PubMed Central

    2011-01-01

    Background Aberrant Wnt/β-catenin signaling is associated with breast cancer even though genetic mutations in Wnt signaling components are rare. We have previously demonstrated that Rad6B, an ubiquitin conjugating enzyme, stabilizes β-catenin via polyubiqutin modifications that render β-catenin insensitive to proteasomal degradation. Rad6B is a transcriptional target of β-catenin, creating a positive feedback loop between Rad6B expression and β-catenin activation. Methods To isolate subpopulations expressing high or low Rad6B levels, we transfected MDA-MB-231 or WS-15 human breast cancer cells with ZsGreen fluorescent reporter vector in which the expression of ZsGreen was placed under the control of Rad6B promoter. ZsGreenhigh and ZsGreenlow subpopulations, reflective of high and low Rad6B promoter activity, respectively, were isolated by FACS. To determine the relevance of Wnt signaling in Rad6B-mediated β-catenin stabilization/activation, the ZsGreenhigh cells were transfected with signaling-defective Wnt coreceptor LRP6Δ173. Rad6B expression and promoter activity were determined by RT-PCR, Western blot and Rad6B promoter-mediated luciferase assays. β-catenin levels and transcriptional activity were determined by Western blot and TOP/FOP Flash reporter assays. Tumor formation and morphologies of ZsGreenlow, ZsGreenhigh, and ZsGreenhigh/LRP6Δ173 cells compared to unsorted vector controls were evaluated in nude mice. Expression of Wnt signaling related genes was profiled using the Wnt signaling pathway RT2 Profiler PCR arrays. Results ZsGreenhigh subpopulations showed high Rad6B expression and Rad6B promoter activity as compared to ZsGreenlow cells. ZsGreenhigh (high Rad6B expressors) also showed elevated β-catenin levels and TOP/Flash activity. Inhibiting Wnt signaling in the high Rad6B expressors decreased ZsGreen fluorescence, Rad6B gene expression, β-catenin levels and TOP/Flash activity. Tumors derived from high Rad6B expressors were predominantly

  3. Acting Atoms.

    ERIC Educational Resources Information Center

    Farin, Susan Archie

    1997-01-01

    Describes a fun game in which students act as electrons, protons, and neutrons. This activity is designed to help students develop a concrete understanding of the abstract concept of atomic structure. (DKM)

  4. Human Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P) regulates cytoplasmic lipid droplet abundance: A potential target for indirect-acting anti-dengue virus agents

    PubMed Central

    Hyrina, Anastasia; Meng, Fanrui; McArthur, Steven J.; Eivemark, Sharlene; Nabi, Ivan R.; Jean, François

    2017-01-01

    Viral hijacking and manipulation of host-cell biosynthetic pathways by human enveloped viruses are shared molecular events essential for the viral lifecycle. For Flaviviridae members such as hepatitis C virus and dengue virus (DENV), one of the key subsets of cellular pathways that undergo manipulation is the lipid metabolic pathways, underlining the importance of cellular lipids and, in particular, lipid droplets (LDs) in viral infection. Here, we hypothesize that targeting cellular enzymes that act as key regulators of lipid homeostasis and LD formation could represent a powerful approach to developing a novel class of broad-spectrum antivirals against infection associated with all DENV serotypes (1–4) circulating around the world. Using PF-429242, an active-site-directed inhibitor of SKI-1/S1P, we demonstrate that inhibition of SKI-1/S1P enzymatic activity in human hepatoma Huh-7.5.1 cells results in a robust reduction of the LD numbers and LD-positive areas and provides a means of effectively inhibiting infection by DENV (1–4). Pre-treatment of Huh-7.5.1 cells with PF-429242 results in a dose-dependent inhibition of DENV infection [median inhibitory dose (EC50) = 1.2 microM; median cytotoxic dose (CC50) = 81 microM; selectivity index (SI) = 68)] and a ~3-log decrease in DENV-2 titer with 20 microM of PF-429242. Post-treatment of DENV-2 infected Huh-7.5.1 cells with PF-429242 does not affect viral RNA abundance, but it does compromise the assembly and/or release of infectious virus particles. PF-429242 antiviral activity is reversed by exogenous oleic acid, which acts as an inducer of LD formation in PF-429242-treated and non-treated control cells. Collectively, our results demonstrate that human SKI-1/S1P is a potential target for indirect-acting pan-serotypic anti-DENV agents and reveal new therapeutic opportunities associated with the use of lipid-modulating drugs for controlling DENV infection. PMID:28339489

  5. Multimodal entity coreference for cervical dysplasia diagnosis.

    PubMed

    Song, Dezhao; Kim, Edward; Huang, Xiaolei; Patruno, Joseph; Munoz-Avila, Hector; Heflin, Jeff; Long, L Rodney; Antani, Sameer

    2015-01-01

    Cervical cancer is the second most common type of cancer for women. Existing screening programs for cervical cancer, such as Pap Smear, suffer from low sensitivity. Thus, many patients who are ill are not detected in the screening process. Using images of the cervix as an aid in cervical cancer screening has the potential to greatly improve sensitivity, and can be especially useful in resource-poor regions of the world. In this paper, we develop a data-driven computer algorithm for interpreting cervical images based on color and texture. We are able to obtain 74% sensitivity and 90% specificity when differentiating high-grade cervical lesions from low-grade lesions and normal tissue. On the same dataset, using Pap tests alone yields a sensitivity of 37% and specificity of 96%, and using HPV test alone gives a 57% sensitivity and 93% specificity. Furthermore, we develop a comprehensive algorithmic framework based on Multimodal Entity Coreference for combining various tests to perform disease classification and diagnosis. When integrating multiple tests, we adopt information gain and gradient-based approaches for learning the relative weights of different tests. In our evaluation, we present a novel algorithm that integrates cervical images, Pap, HPV, and patient age, which yields 83.21% sensitivity and 94.79% specificity, a statistically significant improvement over using any single source of information alone.

  6. The Arabidopsis bHLH Transcription Factors MYC3 and MYC4 Are Targets of JAZ Repressors and Act Additively with MYC2 in the Activation of Jasmonate Responses[C][W

    PubMed Central

    Fernández-Calvo, Patricia; Chini, Andrea; Fernández-Barbero, Gemma; Chico, José-Manuel; Gimenez-Ibanez, Selena; Geerinck, Jan; Eeckhout, Dominique; Schweizer, Fabian; Godoy, Marta; Franco-Zorrilla, José Manuel; Pauwels, Laurens; Witters, Erwin; Puga, María Isabel; Paz-Ares, Javier; Goossens, Alain; Reymond, Philippe; De Jaeger, Geert; Solano, Roberto

    2011-01-01

    Jasmonates (JAs) trigger an important transcriptional reprogramming of plant cells to modulate both basal development and stress responses. In spite of the importance of transcriptional regulation, only one transcription factor (TF), the Arabidopsis thaliana basic helix-loop-helix MYC2, has been described so far as a direct target of JAZ repressors. By means of yeast two-hybrid screening and tandem affinity purification strategies, we identified two previously unknown targets of JAZ repressors, the TFs MYC3 and MYC4, phylogenetically closely related to MYC2. We show that MYC3 and MYC4 interact in vitro and in vivo with JAZ repressors and also form homo- and heterodimers with MYC2 and among themselves. They both are nuclear proteins that bind DNA with sequence specificity similar to that of MYC2. Loss-of-function mutations in any of these two TFs impair full responsiveness to JA and enhance the JA insensitivity of myc2 mutants. Moreover, the triple mutant myc2 myc3 myc4 is as impaired as coi1-1 in the activation of several, but not all, JA-mediated responses such as the defense against bacterial pathogens and insect herbivory. Our results show that MYC3 and MYC4 are activators of JA-regulated programs that act additively with MYC2 to regulate specifically different subsets of the JA-dependent transcriptional response. PMID:21335373

  7. 14 CFR Sec. 1-6 - Accounting entities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Accounting entities. Sec. 1-6 Section 1-6... REGULATIONS UNIFORM SYSTEM OF ACCOUNTS AND REPORTS FOR LARGE CERTIFICATED AIR CARRIERS General Accounting Provisions Sec. 1-6 Accounting entities. (a) Separate accounting records shall be maintained for each...

  8. 14 CFR Sec. 1-6 - Accounting entities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Accounting entities. Sec. 1-6 Section 1-6... REGULATIONS UNIFORM SYSTEM OF ACCOUNTS AND REPORTS FOR LARGE CERTIFICATED AIR CARRIERS General Accounting Provisions Sec. 1-6 Accounting entities. (a) Separate accounting records shall be maintained for each...

  9. 14 CFR Sec. 1-6 - Accounting entities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Accounting entities. Sec. 1-6 Section 1-6... REGULATIONS UNIFORM SYSTEM OF ACCOUNTS AND REPORTS FOR LARGE CERTIFICATED AIR CARRIERS General Accounting Provisions Sec. 1-6 Accounting entities. (a) Separate accounting records shall be maintained for each...

  10. 78 FR 45051 - Unincorporated Business Entities; Effective Date

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-26

    ... institutions' use of unincorporated business entities organized under State law for certain business activities... business entities (UBEs) organized under State law for certain business activities. A UBE includes limited... business trusts, organized under State law. The final rule does not apply to UBEs that one or more...

  11. 45 CFR 162.923 - Requirements for covered entities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... adopted under this part (or within the same covered entity), using electronic media, a transaction for... the format requirements of the standard. (c) Use of a business associate. A covered entity may use a business associate, including a health care clearinghouse, to conduct a transaction covered by this...

  12. 49 CFR 37.29 - Private entities providing taxi service.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Private entities providing taxi service. 37.29 Section 37.29 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Applicability § 37.29 Private entities providing taxi service....

  13. 49 CFR 37.29 - Private entities providing taxi service.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Private entities providing taxi service. 37.29 Section 37.29 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Applicability § 37.29 Private entities providing taxi service....

  14. 49 CFR 37.29 - Private entities providing taxi service.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Private entities providing taxi service. 37.29 Section 37.29 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Applicability § 37.29 Private entities providing taxi service....

  15. 49 CFR 37.29 - Private entities providing taxi service.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Private entities providing taxi service. 37.29 Section 37.29 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Applicability § 37.29 Private entities providing taxi service....

  16. 26 CFR 1.892-5 - Controlled commercial entity.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 9 2011-04-01 2011-04-01 false Controlled commercial entity. 1.892-5 Section 1.892-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Miscellaneous Provisions § 1.892-5 Controlled commercial entity....

  17. 26 CFR 1.892-5 - Controlled commercial entity.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Controlled commercial entity. 1.892-5 Section 1.892-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Miscellaneous Provisions § 1.892-5 Controlled commercial entity. (a)-(a)(2) ....

  18. 78 FR 19271 - Special Fraud Alert: Physician-Owned Entities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... HUMAN SERVICES Office of Inspector General Special Fraud Alert: Physician-Owned Entities AGENCY: Office of Inspector General (OIG), HHS. ACTION: Notice. SUMMARY: This Special Fraud Alert addresses.... Introduction This Special Fraud Alert addresses physician-owned entities that derive revenue from selling,...

  19. 7 CFR 25.401 - Responsibility of lead managing entity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... lead managing entity will be responsible for strategic plan program activities and monitoring the fiscal management of the funds of the Empowerment Zone or Enterprise Community. (b) Reporting. The lead.... All entities with significant involvement in implementing the strategic plan shall cooperate with...

  20. 7 CFR 25.401 - Responsibility of lead managing entity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... lead managing entity will be responsible for strategic plan program activities and monitoring the fiscal management of the funds of the Empowerment Zone or Enterprise Community. (b) Reporting. The lead.... All entities with significant involvement in implementing the strategic plan shall cooperate with...

  1. 7 CFR 25.401 - Responsibility of lead managing entity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... lead managing entity will be responsible for strategic plan program activities and monitoring the fiscal management of the funds of the Empowerment Zone or Enterprise Community. (b) Reporting. The lead.... All entities with significant involvement in implementing the strategic plan shall cooperate with...

  2. 7 CFR 25.401 - Responsibility of lead managing entity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... lead managing entity will be responsible for strategic plan program activities and monitoring the fiscal management of the funds of the Empowerment Zone or Enterprise Community. (b) Reporting. The lead.... All entities with significant involvement in implementing the strategic plan shall cooperate with...

  3. 43 CFR 426.8 - Nonresident aliens and foreign entities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Nonresident aliens and foreign entities..., DEPARTMENT OF THE INTERIOR ACREAGE LIMITATION RULES AND REGULATIONS § 426.8 Nonresident aliens and foreign... reclamation law or these regulations, a nonresident alien or foreign entity that directly holds land in...

  4. 43 CFR 426.8 - Nonresident aliens and foreign entities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Nonresident aliens and foreign entities..., DEPARTMENT OF THE INTERIOR ACREAGE LIMITATION RULES AND REGULATIONS § 426.8 Nonresident aliens and foreign... reclamation law or these regulations, a nonresident alien or foreign entity that directly holds land in...

  5. 43 CFR 426.8 - Nonresident aliens and foreign entities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Nonresident aliens and foreign entities..., DEPARTMENT OF THE INTERIOR ACREAGE LIMITATION RULES AND REGULATIONS § 426.8 Nonresident aliens and foreign... reclamation law or these regulations, a nonresident alien or foreign entity that directly holds land in...

  6. 43 CFR 426.8 - Nonresident aliens and foreign entities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Nonresident aliens and foreign entities..., DEPARTMENT OF THE INTERIOR ACREAGE LIMITATION RULES AND REGULATIONS § 426.8 Nonresident aliens and foreign... reclamation law or these regulations, a nonresident alien or foreign entity that directly holds land in...

  7. 43 CFR 426.8 - Nonresident aliens and foreign entities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Nonresident aliens and foreign entities..., DEPARTMENT OF THE INTERIOR ACREAGE LIMITATION RULES AND REGULATIONS § 426.8 Nonresident aliens and foreign... reclamation law or these regulations, a nonresident alien or foreign entity that directly holds land in...

  8. 49 CFR 37.29 - Private entities providing taxi service.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Private entities providing taxi service. 37.29 Section 37.29 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Applicability § 37.29 Private entities providing taxi service....

  9. When Depression Mediates the Relationship between Entity Beliefs and Performance

    ERIC Educational Resources Information Center

    Da Fonseca, David; Cury, Francois; Santos, Andreia; Payen, Vincent; Bounoua, Lenda; Brisswalter, Jeannick; Rufo, Marcel; Poinso, Francois; Deruelle, Christine

    2009-01-01

    The aim of this study was to determine whether depression can explain the negative relationship between academic performance and the belief that intelligence is a fixed trait, i.e., entity belief. A sample of 353 French volunteer adolescents (age 11-16) completed questionnaires assessing entity theory and depressive symptoms (Children Depression…

  10. 31 CFR 306.88 - Political entities and public corporations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... corporations. 306.88 Section 306.88 Money and Finance: Treasury Regulations Relating to Money and Finance... entities and public corporations. Securities registered in the name of, or assigned to, a State, county, city, town, village, school district or other political entity, public body or corporation, may...

  11. 14 CFR Sec. 1-6 - Accounting entities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... REGULATIONS UNIFORM SYSTEM OF ACCOUNTS AND REPORTS FOR LARGE CERTIFICATED AIR CARRIERS General Accounting Provisions Sec. 1-6 Accounting entities. (a) Separate accounting records shall be maintained for each air... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Accounting entities. Sec. 1-6 Section...

  12. 78 FR 50396 - Common Format for Federal Entity Transition Plans

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ... that federal relocation efforts be based on the suggested EA rankings. However, the report also... entity of the eligible frequencies to be auctioned; (2) the geographic location of the federal entity's... frequencies, including timelines for specific geographic locations in sufficient detail to indicate when...

  13. 24 CFR 578.69 - Cooperation among entities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 3 2013-04-01 2013-04-01 false Cooperation among entities. 578.69 Section 578.69 Housing and Urban Development Regulations Relating to Housing and Urban Development... Cooperation among entities. An HPC must cooperate with HUD in distributing information about its...

  14. 24 CFR 578.69 - Cooperation among entities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true Cooperation among entities. 578.69 Section 578.69 Housing and Urban Development Regulations Relating to Housing and Urban Development... Cooperation among entities. An HPC must cooperate with HUD in distributing information about its...

  15. BEST: Next-Generation Biomedical Entity Search Tool for Knowledge Discovery from Biomedical Literature

    PubMed Central

    Lee, Kyubum; Choi, Jaehoon; Kim, Seongsoon; Jeon, Minji; Lim, Sangrak; Choi, Donghee; Kim, Sunkyu; Tan, Aik-Choon

    2016-01-01

    As the volume of publications rapidly increases, searching for relevant information from the literature becomes more challenging. To complement standard search engines such as PubMed, it is desirable to have an advanced search tool that directly returns relevant biomedical entities such as targets, drugs, and mutations rather than a long list of articles. Some existing tools submit a query to PubMed and process retrieved abstracts to extract information at query time, resulting in a slow response time and limited coverage of only a fraction of the PubMed corpus. Other tools preprocess the PubMed corpus to speed up the response time; however, they are not constantly updated, and thus produce outdated results. Further, most existing tools cannot process sophisticated queries such as searches for mutations that co-occur with query terms in the literature. To address these problems, we introduce BEST, a biomedical entity search tool. BEST returns, as a result, a list of 10 different types of biomedical entities including genes, diseases, drugs, targets, transcription factors, miRNAs, and mutations that are relevant to a user’s query. To the best of our knowledge, BEST is the only system that processes free text queries and returns up-to-date results in real time including mutation information in the results. BEST is freely accessible at http://best.korea.ac.kr. PMID:27760149

  16. BEST: Next-Generation Biomedical Entity Search Tool for Knowledge Discovery from Biomedical Literature.

    PubMed

    Lee, Sunwon; Kim, Donghyeon; Lee, Kyubum; Choi, Jaehoon; Kim, Seongsoon; Jeon, Minji; Lim, Sangrak; Choi, Donghee; Kim, Sunkyu; Tan, Aik-Choon; Kang, Jaewoo

    2016-01-01

    As the volume of publications rapidly increases, searching for relevant information from the literature becomes more challenging. To complement standard search engines such as PubMed, it is desirable to have an advanced search tool that directly returns relevant biomedical entities such as targets, drugs, and mutations rather than a long list of articles. Some existing tools submit a query to PubMed and process retrieved abstracts to extract information at query time, resulting in a slow response time and limited coverage of only a fraction of the PubMed corpus. Other tools preprocess the PubMed corpus to speed up the response time; however, they are not constantly updated, and thus produce outdated results. Further, most existing tools cannot process sophisticated queries such as searches for mutations that co-occur with query terms in the literature. To address these problems, we introduce BEST, a biomedical entity search tool. BEST returns, as a result, a list of 10 different types of biomedical entities including genes, diseases, drugs, targets, transcription factors, miRNAs, and mutations that are relevant to a user's query. To the best of our knowledge, BEST is the only system that processes free text queries and returns up-to-date results in real time including mutation information in the results. BEST is freely accessible at http://best.korea.ac.kr.

  17. Dual-action Hybrid Compounds - A New Dawn in the Discovery of Multi-target Drugs: Lead Generation Approaches.

    PubMed

    Abdolmalekia, Azizeh; Ghasemi, Jahan B

    2016-09-27

    Finding high quality beginning compounds is a critical job at the start of the lead generation stage for multi-target drug discovery (MTDD). Designing hybrid compounds as a selective multi-target chemical entity is a challenge, opportunity, and new idea to better act against specific multiple targets. One hybrid molecule is formed by two (or more) pharmacophore group's participation. So, these new compounds often exhibit two or more activities going about as multi-target drugs (mt-drugs) and may have superior safety or efficacy. Application of integrating a range of information and sophisticated new in silico, bioinformatics, structural biology, pharmacogenomics methods may be useful to discover/design, and synthesis of the new hybrid molecules. In this regard, many rational and screening approaches have followed by medicinal chemists for the lead generation in MTDD. Here, we review some popular lead generation approaches that have been used for designing multiple ligands (DMLs). This paper focuses on dual- acting chemical entities that incorporate a part of two drugs or bioactive compounds to compose hybrid molecules. Also, it presents some of key concepts and limitations/strengths of lead generation methods by comparing combination framework method with screening approaches. Besides, a number of examples to represent applications of hybrid molecules in the drug discovery are included.

  18. Inflammatory breast carcinoma: pathological or clinical entity?

    PubMed

    Amparo, R S; Angel, C D; Ana, L H; Antonio, L C; Vicente, M S; Carlos, F M; Vicente, G P

    2000-12-01

    Inflammatory breast carcinoma (IBC) diagnosis is usually based in the presence of typical clinical symptoms (redness and edema in more than 2/3 of the breast), which are not always associated with pathologic characteristics (subdermal lymphatics involvement). Whether exclusively pathologic findings without clinical symptoms are sufficient for IBC diagnosis remains controversial. A retrospective analysis of 163 clinically diagnosed IBC (CIC) either with dermal lymphatics invasion or not, was compared with another group of 99 patients with dermal lymphatics invasion without clinical symptoms (occult inflammatory carcinoma) (OIC). The following clinical and pathological characteristics have been analyzed and compared: age, menopausal status, clinical axillar node involvement, symptoms duration before diagnosis, grade, estrogen receptors, presence of metastases at diagnosis, local recurrence, metastasic dissemination, disease-free (DFS) and overall survival (OS). Median age was younger in CIC (52.3 vs. 63.8 years; p < 0.001). Symptom duration before diagnosis were significantly shorter in CIC (3.4 vs. 6.8 months: p < 0.0001). Visceral (36.2% vs. 17.2%; p = 0.001) and brain metastases (7.4% vs. 1%; p = 0.02) was significantly more frequent in CIC. Negative estrogen receptors were more frequent in CIC (34.9% vs. 65.1%: p < 0.004). Five-years DFS (25.6 vs. 51.6%; p < 0.0001) and OS (28.6 vs. 40%; p < 0.05) were shorter in CIC. CIC (regardless of subdermal lymphatics involvement) must be clearly differentiated from OIC. Prognosis of CIC patients is poorer, so this two entities should be clearly differentiated when therepeutic results are reported.

  19. Target Practice and Marksmanship Training Support Act

    THOMAS, 111th Congress

    Sen. Udall, Mark [D-CO

    2009-09-23

    09/23/2009 Read twice and referred to the Committee on Environment and Public Works. (text of measure as introduced: CR S9748) (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  20. Target Practice and Marksmanship Training Support Act

    THOMAS, 112th Congress

    Sen. Udall, Mark [D-CO

    2011-06-22

    04/24/2012 Committee on Environment and Public Works Subcommittee on Water and Wildlife. Hearings held. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation: