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Sample records for act tsca chemical

  1. Testing decisions of the TSCA Interagency Testing Committee for chemicals on the Canadian Environmental Protection Act Domestic Substances List and Priority Substances List: Di-tert-butylphenol, ethyl benzene, brominated flame retardants, phthalate esters, chloroparaffins, chlorinated benzenes, and anilines

    SciTech Connect

    Walker, J.D.

    1996-12-31

    In 1976, under section 4(e) of the Toxic Substances Control Act (TSCA), the US Congress created the TSCA Interagency Testing Committee (ITC) to decide which chemicals should be recommended to the Administrator of the US Environmental Protection Agency for testing. In 1988, under the Canadian Environmental Protection Act (CEPA), the Government of Canada created the Domestic Substances List and Priority Substances List. This paper briefly describes the ITC, the different ITC testing decisions and a few of the ITC`s 11,150 testing decisions for the 21,413 chemicals on the CEPA Domestic Substances List and some of the 24 testing decisions for the 44 chemicals and chemical groups on the CEPA.

  2. Structure activity relationships to assess new chemicals under TSCA

    SciTech Connect

    Auletta, A.E.

    1990-12-31

    Under Section 5 of the Toxic Substances Control Act (TSCA), manufacturers must notify the US Environmental Protection Agency (EPA) 90 days before manufacturing, processing, or importing a new chemical substance. This is referred to as a premanufacture notice (PMN). The PMN must contain certain information including chemical identity, production volume, proposed uses, estimates of exposure and release, and any health or environmental test data that are available to the submitter. Because there is no explicit statutory authority that requires testing of new chemicals prior to their entry into the market, most PMNs are submitted with little or no data. As a result, EPA has developed special techniques for hazard assessment of PMN chemicals. These include (1) evaluation of available data on the chemical itself, (2) evaluation of data on analogues of the PMN, or evaluation of data on metabolites or analogues of metabolites of the PMN, (3) use of quantitative structure activity relationships (QSARs), and (4) knowledge and judgement of scientific assessors in the interpretation and integration of the information developed in the course of the assessment. This approach to evaluating potential hazards of new chemicals is used to identify those that are most in need of addition review of further testing. It should not be viewed as a replacement for testing. 4 tabs.

  3. The TSCA interagency testing committee`s approaches to screening and scoring chemicals and chemical groups: 1977-1983

    SciTech Connect

    Walker, J.D.

    1990-12-31

    This paper describes the TSCA interagency testing committee`s (ITC) approaches to screening and scoring chemicals and chemical groups between 1977 and 1983. During this time the ITC conducted five scoring exercises to select chemicals and chemical groups for detailed review and to determine which of these chemicals and chemical groups should be added to the TSCA Section 4(e) Priority Testing List. 29 refs., 1 fig., 2 tabs.

  4. 78 FR 52525 - Dichloromethane and N-Methylpyrrolidone TSCA Chemical Risk Assessment; Notice of Public Meetings...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ... provide any technical information and/or data that you used. v. If you estimate potential costs or burdens... notice in the Federal Register (78 FR 1856) (FRL-9375-1) on the availability of five draft TSCA chemical... (DCM and NMP) (CASRN 75-09-2 and 872-50-4) are two of 83 chemicals identified for review and...

  5. 78 FR 59679 - Antimony Trioxide TSCA Chemical Risk Assessment; Notice of Public Meetings and Opportunity To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-27

    ... of boxed information. Instructions: Direct your comments to docket ID number EPA-HQ-OPPT- 2012-0724... notice in the Federal Register (78 FR 1856) (FRL-9375-1) on the availability of five draft TSCA chemical... speaker is encouraged to focus on issues directly relevant to science-based aspects of the draft ATO...

  6. 78 FR 64936 - Dichloromethane and N-Methylpyrrolidone TSCA Chemical Risk Assessment; Notice of Rescheduled...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-30

    ... published in the Federal ] Register of August 23, 2013 (78 FR 52525) (FRL 9397-4). The first meeting was... AGENCY Dichloromethane and N-Methylpyrrolidone TSCA Chemical Risk Assessment; Notice of Rescheduled... Risk Assessment for Dichloromethane and N-Methylpyrrolidone.'' The first meeting was held as...

  7. Impacts & Compliance Implementation Plans & Required Deviations for Toxic Substance Control Act (TSCA) Regulation of Double Shell Tanks (DST)

    SciTech Connect

    MULKEY, C.H.

    2000-08-22

    In May 2000, the U.S. Department of Energy, Office of River Protection (DOE-ORP) and the U.S. Environmental Protection Agency (EPA) held meetings regarding the management of polychlorinated biphenyls (PCBs) in the Hanford tank waste. It was decided that the radioactive waste currently stored in the double-shell tanks (DSTs) contain waste which will become subject to the Toxic Substance Control Act (TSCA) (40 CFR 761). As a result, DOE-ORP directed the River Protection Project tank farm contractor (TFC) to prepare plans for managing the PCB inventory in the DSTs. Two components of the PCB management plans are this assessment of the operational impacts of TSCA regulation and the identifications of deviations from TSCA that are required to accommodate tank farm unique limitations. This plan provides ORP and CH2M HILL Hanford Group, Inc. (CHG) with an outline of TSCA PCB requirements and their applicability to tank farm activities, and recommends a compliance/implementation approach. Where strict compliance is not possible, the need for deviations from TSCA PCB requirements is identified. The purpose of assembling this information is to enhance the understanding of PCB management requirements, identify operational impacts and select impact mitigation strategies. This information should be useful in developing formal agreements with EPA where required.

  8. Oak Ridge Toxic Substances Control Act (TSCA) Incinerator test bed for continuous emissions monitoring systems (CEMS)

    SciTech Connect

    Gibson, L.V. Jr.

    1997-12-31

    The Toxic Substances Control Act (TSCA) Incinerator, located on the K-25 Site at Oak Ridge, Tennessee, continues to be the only operational incinerator in the country that can process hazardous and radioactively contaminated polychlorinated biphenyl (PCB) waste. During 1996, the US Department of Energy (DOE) Environmental Management Office of Science and Technology (EM-50) and Lockheed Martin Energy Systems established a continuous emissions monitoring systems (CEMS) test bed and began conducting evaluations of CEMS under development to measure contaminants from waste combustion and thermal treatment stacks. The program was envisioned to promote CEMS technologies meeting requirements of the recently issued Proposed Standards for Hazardous Waste Combustors as well as monitoring technologies that will allay public concerns about mixed waste thermal treatment and accelerate the development of innovative treatment technologies. Fully developed CEMS, as well as innovative continuous or semi-continuous sampling systems not yet interfaced with a pollutant analyzer, were considered as candidates for testing and evaluation. Complementary to other Environmental Protection Agency and DOE sponsored CEMS testing and within compliant operating conditions of the TSCA Incinerator, prioritization was given to multiple metals monitors also having potential to measure radionuclides associated with particulate emissions. In August 1996, developers of two multiple metals monitors participated in field activities at the incinerator and a commercially available radionuclide particulate monitor was acquired for modification and testing planned in 1997. This paper describes the CEMS test bed infrastructure and summarizes completed and planned activities.

  9. 76 FR 38169 - Toxic Substances Control Act Chemical Testing; Receipt of Test Data

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... AGENCY Toxic Substances Control Act Chemical Testing; Receipt of Test Data AGENCY: Environmental... chemicals listed in the Toxic Substances Control Act (TSCA) section 4 test rule titled ``In Vitro Dermal Absorption Rate Testing of Certain Chemicals of Interest to the Occupational Safety and Health...

  10. TSCA Work Plan Chemical Risk Assessment: 1-Bromopropane

    EPA Science Inventory

    1-Bromopropane (CASRN 106-94-5): or 1-BP is a volatile organic chemical that is considered moderately persistent in the environment but does not have the potential to bioaccumulate in fish or other animals. The majority of the 1-BP production volume (~ 47%) is used as a vapor deg...

  11. The TSCA Interagency Testing Committee (ITC) proposed strategy for identifying and coordinating U.S. government data needs for endocrine-disrupting chemicals

    SciTech Connect

    Walker, J.D.

    1995-12-31

    The ITC`s Endocrine-Disrupting Chemicals Subcommittee will implement a proposed strategy for identifying and coordinating the US government ecological and health effects data needs for endocrine-disrupting chemicals, These include chemicals with potential to cause reproductive, developmental, immunological, neurologic or other biological effects by adversely affecting endocrine tissues, hormones or receptors in fish, wildlife or humans. To meet these needs, the Subcommittee will consider three options. First, the information collecting authority of the Toxic Substances Control Act (TSCA) will be considered as a cost-effective mechanism to rapidly (within 60 days) obtain unpublished health and ecological effects studies related to reproductive effects and endocrine-disrupting activity. Second, the chemical testing authority of TSCA will be considered as a method to request that the manufacturers of endocrine-disrupting chemicals conduct tests that are amenable to standardization. Third, consideration will be given to coordinating standardized testing with testing related to research and to using the results of this research to develop standardized methods for assessing the effects of endocrine-disrupting chemicals. The Subcommittee will focus on 16 alkylphenol and alkylphenol ethoxylates with 1989 production or importation volumes greater than 1 million pounds that were identified using the Substructure based Computerized Chemical Selection Expert System (SuCCSES). The ITC`s proposed strategy will be discussed.

  12. 75 FR 49655 - TSCA Inventory Update Reporting Modifications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-13

    ...The Toxic Substances Control Act (TSCA) Inventory Update Reporting (IUR) rule enables EPA to collect and then make public critical information on the manufacturing, processing, and use of commercial chemicals, including current information on volumes of chemical production, manufacturing facility data, and how the chemicals are used. This information helps the Agency determine whether......

  13. Regulating the introduction of new chemicals under section 5 of TSCA: improving the efficiency of the process and reducing potential injury in the workplace through the use of operational MSDS and exposure limits.

    PubMed

    Rosenthal, I; Jayjock, M A; Keener, R L; Plamondon, J E

    1991-10-01

    The Toxic Substances Control Act (TSCA) authorizes the EPA to take appropriate actions to ensure that new and existing chemicals do not pose "unreasonable risk" to health or the environment. Section 2(b)(3) of the Act directs the Agency to accomplish this objective in a manner that does "not impede unduly or create unnecessary economic barriers to technological innovation." In recent years, critics have felt that the EPA has failed to achieve these primary goals of TSCA. This paper considers some of the reasons for this criticism and advocates an alternate approach of exposure limits and operationally sufficient controls to assist in achieving these goals. An illustration of how this alternate approach might work under practical conditions is presented, using as an example a new chemical substance from the class of acrylate monomers. These concepts and risk assessments provide data for a better design of future studies according to good laboratory practice and quality assurance. PMID:1669965

  14. Field testing of particulate matter continuous emission monitors at the DOE Oak Ridge TSCA incinerator. Toxic Substances Control Act.

    PubMed

    Dunn, James E; Davis, Wayne T; Calcagno, James A; Allen, Marshall W

    2002-01-01

    A field study to evaluate the performance of three commercially available particulate matter (PM) continuous emission monitors (CEMs) was conducted in 1999-2000 at the US Department of Energy (DOE) Toxic Substances Control Act (TSCA) Incinerator. This study offers unique features that are believed to enhance the collective US experience with PM CEMs. The TSCA Incinerator is permitted to treat PCB-contaminated RCRA hazardous low-level radioactive wastes. The air pollution control system utilizes MACT control technology and is comprised of a rapid quench, venturi scrubber, packed bed scrubber, and two ionizing wet scrubbers in series, which create a saturated flue gas that must be conditioned by the CEMs prior to measurement. The incinerator routinely treats a wide variety of wastes including high and low BTU organic liquids, aqueous, and solid wastes. The various possible combinations for treating liquid and solid wastes may present a challenge in establishing a single, acceptable correlation relationship for individual CEMs. The effect of low-level radioactive material present in the waste is a unique site-specific factor not evaluated in previous tests. The three systems chosen for evaluation were two beta gauge devices and a light scattering device. The performance of the CEMs was evaluated using the requirements in draft Environmental Protection Agency (EPA) Performance Specification 11 (PS11) and Procedure 2. The results of Reference Method 5i stack tests for establishing statistical correlations between the reference method data and the CEMs responses are discussed.

  15. Dynamic computer model for heat transfer and incineration in the Oak Ridge TSCA (Toxic Substances Control Act) hazardous waste incinerator

    SciTech Connect

    Clinton, J.H.

    1989-01-01

    The Oak Ridge Toxic Substances Control Act (TSCA) incinerator was designed to burn toxic wastes such as PCBs. During the course of certification, concern was expressed by the Environmental Protection Agency that unburned PCBs might not continue to be destructed if the ''burning'' in the incinerator ceased. For example, it is possible that the flow of auxiliary fuel could be interrupted during the course of incinerator operation. The situation could occur at the time when a fresh batch of waste was introduced into the incinerator which would be the worst time for normal incinerator operation to cease. In response to the question concerning the destruction of PCBs during such an accidental cooling period, a dynamic model was constructed to approximate the situation, and thus obtain an estimate of the time period that the exit gas would remain above the necessary temperature required to detoxify the undesirable substance.

  16. 75 FR 8266 - Final Clarification for Chemical Identification Describing Activated Phosphors for TSCA Inventory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... in the Federal Register issue of January 16, 2008 (73 FR 2854) (FRL-8131-8) and a reopening of comments on the proposed clarification was announced in the Federal Register issue of May 2, 2008 (73 FR... Federal Register issue of December 23, 1977 (42 FR 64572) under TSCA section 8(a), 15 U.S.C. 2607(a),...

  17. Mode of action and the assessment of chemical hazards in the presence of limited data: use of structure-activity relationships (SAR) under TSCA, Section 5.

    PubMed Central

    Auer, C M; Nabholz, J V; Baetcke, K P

    1990-01-01

    Section 5 of the Toxic Substances Control Act (TSCA) requires that manufacturers and importers of new chemicals must submit a Premanufacture Notification (PMN) to the U.S. Environmental Protection Agency 90 days before they intend to commence manufacture or import. Certain information such as chemical identity, uses, etc., must be included in the notification. The submission of test data on the new substance, however, is not required, although any available health and environmental information must be provided. Nonetheless, over half of all PMNs submitted to the agency do not contain any test data; because PMN chemicals are new, no test data is generally available in the scientific literature. Given this situation, EPA has had to develop techniques for hazard assessment that can be used in the presence of limited test data. EPA's approach has been termed "structure-activity relationships" (SAR) and involves three major components: the first is critical evaluation and interpretation of available toxicity data on the chemical; the second component involves evaluation of test data available on analogous substances and/or potential metabolites; and the third component involves the use of mathematical expressions for biological activity known as "quantitative structure-activity relationships" (QSARs). At present, the use of QSARs is limited to estimating physical chemical properties, environmental toxicity, and bioconcentration factors. An important overarching element in EPA's approach is the experience and judgment of scientific assessors in interpreting and integrating the available data and information. Examples are provided that illustrate EPA's approach to hazard assessment for PMN chemicals. PMID:2269224

  18. Toxic Substances Control Act (TSCA) test submissions database (TSCATS) - comprehensive update (on magnetic tape)

    SciTech Connect

    1996-04-01

    The Toxic Substances Control Act Test Submissions Database (TSCATS) was developed to make unpublished test data available to the public. The test data are submitted to the U.S. Environmental Protection Agency by industry under the Toxic Substances Control Act. Test data are broadly defined to include case reports, episodic incidents, such as spills, and formal test study presentations. The database allows searching of test submissions according to specific chemical identity or type of study when used with an appropriate search retrieval software program. Studies are indexed under three broad subject areas: health effects, environmental effects, and environmental fate. additional controlled vocabulary terms are assigned which describe the experimental protocol and test observations. Records identify reference information needed to locate the source document, the submitting organization, and reason for submission of the test data.

  19. Toxic Substances Control Act (TSCA) Test Submissions Database (TSCATS) - comprehensive update (on magnetic tape). Data file

    SciTech Connect

    1996-07-01

    The Toxic Substances Control Act Test Submissions Database (TSCATS) was developed to make unpublished test data available to the public. The test data are submitted to the U.S. Environmental Protection Agency by industry under the Toxic Substances Control Act. Test data are broadly defined to include case reports, episodic incidents, such as spills, and formal test study presentations. The database allows searching of test submissions formal test study presentations. The database allows searching of test submissions according to specific chemical identity or type of study when used with an appropriate search retrieval software program. Studies are indexed under three broad subject areas: health effects, environmental effects and environmental fate. Additional controlled vocabulary terms are assigned which describe the experimental protocol and test observations. Records identify reference information needed to locate the source document, as well as the submitting organization and reason for submission of the test data.

  20. Toxic Substances Control Act (TSCA) test submissions database (tscats) - comprehensive update (on magnetic tape). Data file

    SciTech Connect

    1995-12-31

    The Toxic Substances Control Act Test Submissions Database (TSCATS) was developed to make unpublished test data available to the public. The test data are submitted to the U.S. Environmental Protection Agency by industry under the Toxic Substances Control Act. Test data are broadly defined to include case reports, episodic incidents, such as spills, and formal test study presentations. The database allows searching of test submissions according to specific chemical identity or type of study when used with an appropriate search retrieval software program. Studies are indexed under three broad subject areas: health effects, environmental effects and environmental fate. Additional controlled vocabulary terms are assigned which describe the experimental protocol and test observations. Records identify reference information needed to locate the source document, as well as the submitting organization and reason for submission of the test data.

  1. Toxic Substances Control Act (TSCA) Test Submissions Database (TSCATS) - comprehensive update (on magnetic tape). Data file

    SciTech Connect

    1996-12-31

    The Toxic Substances Control Act Test Submissions Database (TSCATS) was developed to make unpublished test data available to the public. The test data are submitted to the U.S. Environmental Protection Agency by industry under the Toxic Substances Control Act. Test data are broadly defined to include case reports, episodic incidents, such as spills, and formal test study presentations. The database allows searching of test submissions according to specific chemical identity or type of study when used with an appropriate search retrieval software program. Studies are indexed under three broad subject areas: health effects, environmental effects and environmental fate. Additional controlled vocabulary terms are assigned which describe the experimental protocol and test observations. Records identify reference information needed to locate the source document, as well as the submitting organization and reason for submission of the test data.

  2. Toxic Substances Control Act (TSCA) test submissions database (TSCATS) - comprehensive update (on magnetic tape). Data file

    SciTech Connect

    1996-09-01

    The Toxic Substances Control Act Test Submissions Database (TSCATS) was developed to make unpublished test data available to the public. The test data are submitted to the U.S. Environmental Protection Agency by industry under the Toxic Substances Control Act. Test data are broadly defined to include case reports, episodic incidents, such as spills, and formal test study presentations. The database allows searching of test submissions according to specific chemical identity or type of study when used with an appropriate search retrieval software program. Studies are indexed under three broad subject areas: health effects, environmental effects, and environmental fate. Additional controlled vocabulary terms are assigned which describe the experimental protocol and test observations. Records identify reference information needed to locate the source document, as well as the submitting organization and reason for submission of the test data.

  3. Pushing the environmental regulatory focus a step back: controlling the introduction of new chemicals under the Toxic Substances Control Act.

    PubMed

    Hanan, A

    1992-01-01

    Environmental destruction and its attendant effects on the animal world, including human beings, has moved to the forefront of United States and worldwide policy. The effect of this deterioration on human health is unclear. Much debate focuses on the cases of cancer, along with other diseases, that are environmentally induced. Congress has responded with various environmental laws. These laws focus primarily on controlling chemicals placed into the environment, largely by industry. This Note proposes that such a singular focus is inadequate and ultimately costly. A more sensible and efficient strategy to environmental protection places emphasis on controlling inputs to the productive process before the need arises to contain such substances. The Toxic Substances Control Act of 1976 ("TSCA") takes this approach. This Note reviews the means by which TSCA attempted to accomplish its goals and concludes that TSCA's implementation has largely been ineffective. The Note then discusses three possible explanations for TSCA's failure. Finally, the Note proposes how TSCA might be made more effective in regulating new chemicals.

  4. 40 CFR 799.9135 - TSCA acute inhalation toxicity with histopathology.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Substances Control Act (TSCA). In the assessment and evaluation of the potential human health effects of... detailed microscopic examination to identify adverse effects of chemical substances on this organ system... histopathologic lesions, body weight changes, effects on mortality, and any other toxic effects. These acute...

  5. Human health and the environment can't wait for reform: current opportunities for the federal government and states to address chemical risks under the Toxic Substances Control Act.

    PubMed

    Trevisan, Lauren

    2011-01-01

    Expressing its concern about growing rates of cancer and other diseases, coupled with the lack of data about the effect of the thousands of chemicals used in U.S. society, in 1976 Congress enacted the Toxic Substances Control Act (TSCA). Congress intended for TSCA to shed new light on chemical risks and provide the U.S. Environmental Protection Agency (EPA) with a set of tools to address those risks and protect human health and the environment. In the years since TSCA's passage, the procedural hurdles and the difficult-to-meet legal standards built into the statute, along with a court decision rejecting EPA's use of its authority to ban dangerous chemicals, have impeded EPA's ability to regulate chemical use and manufacture. This Comment argues that both the EPA and state governments have the authority to act now to address the risks posed by dangerous chemicals. By utilizing certain sections of the statute in new and aggressive ways, EPA can effectively address chemical risks. Further, this Comment argues that TSCA's preemption provision affords states leeway to continue to regulate the use of chemicals within their borders. Though reform of TSCA is necessary, EPA and states can effectively protect against chemical risks in the near-term by using the full extent of their authority under the current law.

  6. 76 FR 50815 - TSCA Inventory Update Reporting Modifications; Chemical Data Reporting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-16

    ..., naturally occurring chemical substances, and certain natural gas substances. Manufacturers (including... information reported. EPA believes that expanding the range of chemical substances for which more...

  7. Toxic Substances Control Act (TSCA) Test Submissions Database (TSCATS) - comprehensive update (on cd-rom). Data file

    SciTech Connect

    1997-03-01

    The Toxic Substances Control Act Test Submissions Database (TSCATS) was developed to make unpublished test data available to the public. The test data are submitted to the U.S. Environmental Protection Agency by industry under the Toxic Substances Control Act. Test data are broadly defined to include case reports, episodic incidents, such as spills, and formal test study presentations. The database allows searching of test submissions according to specific chemical identity or type of study when used with an appropriate search retrieval software program. Studies are indexed under three broad subject areas: health effects, environmental effects and environmental fate. Additional controlled vocabulary terms are assigned which describe the experimental protocol and test observations. Records identify reference information needed to locate the source document, as well as the submitting organization and reason for submission of the test data.

  8. Toxic Substances Control Act (TSCA) Polychlorinated Biphenyl (PCB)/Radioactive Waste Annual Inventory for Calendar Year 2014

    SciTech Connect

    Layton, Deborah L.

    2015-06-01

    The Toxic Substances Control Act, 40 CFR 761.65(a)(1) provides an exemption from the one year storage time limit for PCB/radioactive waste. PCB/radioactive waste may exceed the one year time limit provided that the provisions at 40 CFR 761.65(a)(2)(ii) and 40 CFR 761.65(a)(2)(iii) are followed. These two subsections require, (ii) "A written record documenting all continuing attempts to secure disposal is maintained until the waste is disposed of" and (iii) "The written record required by subsection (ii) of this section is available for inspection or submission if requested by EPA." EPA Region 10 has requested the Department of Energy (DOE) to submit an inventory of radioactive-contaminated PCB waste in storage at the Idaho National Laboratory (INL) for the previous calendar year. The annual inventory is separated into two parts, INL without Advanced Mixed Waste Treatment Project (AMWTP) (this includes Battelle Energy Alliance, LLC, CH2M-WG Idaho, LLC, and the Naval Reactors Facility), and AMWTP.

  9. Toxic Substances Control Act (TSCA) Polychlorinated Biphenyl (PCB)/Radioactive Waste Annual Inventory for Calendar Year 2013

    SciTech Connect

    no author on report

    2014-06-01

    The Toxic Substances Control Act, 40 CFR 761.65(a)(1) provides an exemption from the one year storage time limit for PCB/radioactive waste. PCB/radioactive waste may exceed the one year time limit provided that the provisions at 40 CFR 761.65(a)(2)(ii) and 40 CFR 761.65(a)(2)(iii) are followed. These two subsections require, (ii) "A written record documenting all continuing attempts to secure disposal is maintained until the waste is disposed of" and (iii) "The written record required by subsection (ii) of this section is available for inspection or submission if requested by EPA." EPA Region 10 has requested the Department of Energy (DOE) to submit an inventory of radioactive-contaminated PCB waste in storage at the Idaho National Laboratory (INL) for the previous calendar year. The annual inventory is separated into two parts, INL without Advanced Mixed Waste Treatment Project (AMWTP) (this includes Battelle Energy Alliance, LLC, CH2M-WG Idaho, LLC, and the Naval Reactors Facility), and AMWTP.

  10. 75 FR 58377 - Lead in Ammunition and Fishing Sinkers; Disposition of TSCA Section 21 Petition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-24

    ... to regulate lead in bullets and shot under TSCA. EPA's decision is based on the exclusion of shells... have any questions regarding this action, consult the technical person listed under FOR FURTHER... firearms, shells and cartridges from the definition of ``chemical substance'' in TSCA section...

  11. 78 FR 27860 - Revocation of TSCA Section 4 Testing Requirements for One High Production Volume Chemical Substance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-13

    ... Certain High Production Volume Chemicals; Final Rule. Federal Register (71 FR 13708, March 16, 2006) (FRL... Requirements Certain High Production Volume Chemical Substances; Direct Final Rule. Federal Register (77 FR... Substance; Final Rule. Federal Register (77 FR 28281, May 14, 2012) (FRL-9350- 2). Document ID number...

  12. 76 FR 27271 - TSCA Inventory Update Reporting Modifications; Submission Period Suspension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION... Suspension AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: EPA is amending the Toxic Substances Control Act (TSCA) section 8(a) Inventory Update Reporting (IUR) regulations...

  13. 77 FR 28340 - Revocation of TSCA Section 4 Testing Requirements for One High Production Volume Chemical Substance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-14

    ... March 16, 2012 (77 FR 15609) (FRL-9335- 6), EPA issued a revocation of some or all of the testing... High Production Volume Chemicals; Final Rule. Federal Register (71 FR 13708, March 16, 2006) (FRL-7335... significant regulatory action under Executive Order 12866, entitled ``Regulatory Planning and Review'' (58...

  14. 78 FR 41768 - Chemical Substances and Mixtures Used in Oil and Gas Exploration or Production; TSCA Section 21...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-11

    ... Significant Human Exposure; Final Statement of Policy. Federal Register (58 FR 28736, May 14, 1993) (FRL-4059... information related to significant adverse reactions to human health or the environment alleged to have been... reactions received and maintained by manufacturers, processors, and distributors of E&P chemical...

  15. 40 CFR 711.5 - Chemical substances for which information must be reported.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Chemical substances for which information must be reported. 711.5 Section 711.5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL DATA REPORTING REQUIREMENTS § 711.5...

  16. 40 CFR 799.9305 - TSCA Repeated dose 28-day oral toxicity study in rodents.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... dose level. If interim sacrifices are planned, the number should be increased by the number of animals.... Measurements of food consumption should be made at least weekly. If the test substance is administered via the... requirements of the Toxic Substances Control Act (TSCA) (15 U.S.C.......

  17. 77 FR 3725 - Proposed Significant New Use Rules on Certain Chemical Substances; Extension of Comment Period

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-25

    ... 28, 2011 (76 FR 81441) (FRL-9329-4). In that document, EPA proposed SNURs under section 5(a)(2) of... Substances Control Act (TSCA) for the chemical substances rutile, tin zinc, calcium-doped (CAS No. 389623-01- 2) and rutile, tin zinc, sodium-doped (CAS No. 389623-07-8) which were the subject of...

  18. 77 FR 32633 - Approval of Test Marketing Exemptions for Certain New Chemicals

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ... marketing exemptions (TMEs) under section 5(h)(1) of the Toxic Substances Control Act (TSCA). EPA has... Friday, excluding legal holidays. The telephone number of the EPA/DC Public Reading Room is (202) 566... manufacture or import new chemical substances for test marketing purposes, if the Agency finds that...

  19. Glossary of CERCLA, RCRA and TSCA related terms and acronyms. Environmental Guidance

    SciTech Connect

    Not Available

    1993-10-01

    This glossary contains CERCLA, RCRA and TSCA related terms that are most often encountered in the US Department of Energy (DOE) Environmental Restoration and Emergency Preparedness activities. Detailed definitions are included for key terms. The CERCLA definitions included in this glossary are taken from the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA), as amended and related federal rulemakings. The RCRA definitions included in this glossary are taken from the Resource Conservation and Recovery Act (RCRA) and related federal rulemakings. The TSCA definitions included in this glossary are taken from the Toxic Substances and Control Act (TSCA) and related federal rulemakings. Definitions related to TSCA are limited to those sections in the statute and regulations concerning PCBs and asbestos.Other sources for definitions include additional federal rulemakings, assorted guidance documents prepared by the US Environmental Protection Agency (EPA), guidance and informational documents prepared by the US Department of Energy (DOE), and DOE Orders. The source of each term is noted beside the term. Terms presented in this document reflect revised and new definitions published before July 1, 1993.

  20. 76 FR 65385 - Testing of Certain High Production Volume Chemicals; Third Group of Chemicals

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-21

    ...EPA is promulgating this final rule under section 4(a)(1)(B) of the Toxic Substances Control Act (TSCA) to require manufacturers, importers, and processors to conduct testing to obtain screening level data for health and environmental effects and chemical fate for 15 high production volume (HPV) chemical substances listed in this final rule. This test data is needed in order to help EPA to......

  1. In the arc of history: AIHA and the movement to reform the Toxic Substances Control Act.

    PubMed

    Wilson, Michael P

    2012-01-01

    Dr. Michael P. Wilson of UC Berkeley delivered his keynote address before the general assembly of the American Industrial Hygiene Conference and Exhibition (AIHce) in Portland, Oregon, in May 2011. Here, Dr. Wilson again discusses the political and economic drivers of occupational disease in the United States and proposes a role for AIHA in helping to highlight and resolve them. He proposes that until these underlying drivers are acknowledged and ameliorated, the toll of occupational disease will persist, despite the hard work of industrial hygienists in the workplace. Among these drivers, Dr. Wilson points to the decline of labor rights and unionization; economic inequality; economic insecurity; political resistance to public health protections for workers, notably the OSHA and NIOSH programs; and weaknesses in the Federal Toxic Substances Control Act of 1976 (TSCA). Of these, Dr. Wilson calls on the AIHA to participate in the historic effort to rewrite TSCA. He points to weaknesses in TSCA that have produced a chemicals market dominated by the function, price, and performance of chemicals, with little attention given to their health and environmental effects. Under these conditions, he argues, hazardous chemicals have remained economically competitive, and innovation in inherently safer chemicals-in green chemistry-has been held back by a lack of market transparency and public accountability in the industry. TSCA reform has the potential to shift the market toward green chemistry, with long-term implications for occupational disease prevention, industrial investment, and renewed energy in the industrial hygiene profession. Dr. Wilson proposes that, like previous legislative changes in the United States, TSCA reform is likely to occur in response to myriad social pressures, which include the emergence of the European Union's REACH regulation; recent chemicals policy actions in 18 U.S. states; growing support from downstream businesses; increasing public awareness

  2. 77 FR 75349 - Seventy-First Report of the TSCA Interagency Testing Committee to the Administrator of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    .... 3. EPA. Testing of Certain High Production Volume Chemicals; Proposed Rule. Federal Register (65 FR... Testing Committee to the Administrator of the Environmental Protection Agency; Receipt of Report and... / Notices#0;#0; ] ENVIRONMENTAL PROTECTION AGENCY Seventy-First Report of the TSCA Interagency...

  3. U.S. EPA`s use of QSAR for new and existing chemical evaluations: Regulatory aspects

    SciTech Connect

    Zeeman, M.; Clements, R.G.; Nabholz, J.V.; Auer, C.M.

    1994-12-31

    As up front testing is not required, ecotoxicity or fate data are available for only about 5% of the 2,200 new chemicals/year submitted to EPA. The EPA`s Toxic Substances Control Act (TSCA) Inventory of existing chemicals currently lists about 72,000 chemicals. Most of existing chemicals also appear to have little or no ecotoxicity or fate data available. The EPA`s Office of Pollution Prevention and Toxics (OPPT) has developed and relies upon QSARs to estimate the ecotoxicity and fate of most of the new chemicals evaluated for ecological hazard and risk assessment. QSAR methods routinely result in ecotoxicity estimations of acute and sub/chronic toxicity to fish, aquatic invertebrates, and algae, and fate estimations of physical/chemical properties, degradation, and bioconcentration. GSAR methods were also used to screen the TSCA Inventory for the ecotoxicity of specific chemical classes of over 8,000 discrete chemicals. In the latter effort, seven major chemical classes made up almost 95% of these chemicals. From this QSAR analysis, about 10--20% or 15--18% of these chemicals, respectively, are expected to have high acute or high chronic toxicity to aquatic species. Estimates of ecotoxicity for > 8,000 discrete organics enhances prioritization of chemicals on the TSCA Inventory and helps focus EPA/OPPT regulatory efforts upon the potentially most toxic substances.

  4. Chemical safety, health care costs and the Affordable Care Act.

    PubMed

    Landrigan, Philip J; Goldman, Lynn R

    2014-01-01

    On May 22, 2013, the late Senator Frank Lautenberg (D-NJ), Senator David Vitter (R-LA) and 19 of their colleagues introduced bipartisan chemical safety legislation in the US Senate, "The Chemical Safety Improvement Act of 2013." The bill's purpose is to protect human health and the environment against the hazards of toxic chemicals, by requiring the US Environmental Protection Agency (EPA) to examine the safety of all chemicals in consumer products. The bill is currently before the Senate Committee on Environment and Public Works, chaired by Senator Barbara Boxer (D-CA). This legislation is critically important for physicians and healthcare organizations because it creates significant new opportunities to prevent disease and cut healthcare costs. PMID:24136096

  5. Regulating chemicals: law, science, and the unbearable burdens of regulation.

    PubMed

    Silbergeld, Ellen K; Mandrioli, Daniele; Cranor, Carl F

    2015-03-18

    The challenges of regulating industrial chemicals remain unresolved in the United States. The Toxic Substances Control Act (TSCA) of 1976 was the first legislation to extend coverage to the regulation of industrial chemicals, both existing and newly registered. However, decisions related to both law and science that were made in passing this law inevitably rendered it ineffectual. Attempts to fix these shortcomings have not been successful. In light of the European Union's passage of innovative principles and requirements for chemical regulation, it is no longer possible to deny the opportunity and need for reform in US law and practice. PMID:25785889

  6. Regulating chemicals: law, science, and the unbearable burdens of regulation.

    PubMed

    Silbergeld, Ellen K; Mandrioli, Daniele; Cranor, Carl F

    2015-03-18

    The challenges of regulating industrial chemicals remain unresolved in the United States. The Toxic Substances Control Act (TSCA) of 1976 was the first legislation to extend coverage to the regulation of industrial chemicals, both existing and newly registered. However, decisions related to both law and science that were made in passing this law inevitably rendered it ineffectual. Attempts to fix these shortcomings have not been successful. In light of the European Union's passage of innovative principles and requirements for chemical regulation, it is no longer possible to deny the opportunity and need for reform in US law and practice.

  7. 77 FR 11158 - Notice of Lodging of Consent Decree Under the Toxic Substances Control Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-24

    ... chlorinated paraffins and committed to submit premanufacture notices (``PMNs'') for medium and long-chain chlorinated paraffins, pursuant to TSCA Section 5. The proposed Consent Decree prohibits Dover Chemical from manufacturing any chlorinated paraffin product not placed on the TSCA Inventory via the PMN process....

  8. In the arc of history: AIHA and the movement to reform the Toxic Substances Control Act.

    PubMed

    Wilson, Michael P

    2012-01-01

    Dr. Michael P. Wilson of UC Berkeley delivered his keynote address before the general assembly of the American Industrial Hygiene Conference and Exhibition (AIHce) in Portland, Oregon, in May 2011. Here, Dr. Wilson again discusses the political and economic drivers of occupational disease in the United States and proposes a role for AIHA in helping to highlight and resolve them. He proposes that until these underlying drivers are acknowledged and ameliorated, the toll of occupational disease will persist, despite the hard work of industrial hygienists in the workplace. Among these drivers, Dr. Wilson points to the decline of labor rights and unionization; economic inequality; economic insecurity; political resistance to public health protections for workers, notably the OSHA and NIOSH programs; and weaknesses in the Federal Toxic Substances Control Act of 1976 (TSCA). Of these, Dr. Wilson calls on the AIHA to participate in the historic effort to rewrite TSCA. He points to weaknesses in TSCA that have produced a chemicals market dominated by the function, price, and performance of chemicals, with little attention given to their health and environmental effects. Under these conditions, he argues, hazardous chemicals have remained economically competitive, and innovation in inherently safer chemicals-in green chemistry-has been held back by a lack of market transparency and public accountability in the industry. TSCA reform has the potential to shift the market toward green chemistry, with long-term implications for occupational disease prevention, industrial investment, and renewed energy in the industrial hygiene profession. Dr. Wilson proposes that, like previous legislative changes in the United States, TSCA reform is likely to occur in response to myriad social pressures, which include the emergence of the European Union's REACH regulation; recent chemicals policy actions in 18 U.S. states; growing support from downstream businesses; increasing public awareness

  9. 75 FR 29754 - Claims of Confidentiality of Certain Chemical Identities Contained in Health and Safety Studies...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-27

    ... processes used in the manufacturing or processing of a chemical substance or mixture or, in the case of a... on the public version of the TSCA Chemical Substances Inventory (TSCA Inventory) and submitted in..., identified by docket identification (ID) number EPA-HQ-OPPT-2010-0446, by one of the following......

  10. 40 CFR 799.9130 - TSCA acute inhalation toxicity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) Definitions. The definitions in section 3 of TSCA and the definitions in 40 CFR Part 792—Good Laboratory... 40 CFR part 792, subpart f. (3) Test procedures—(i) Preparation. Healthy young adult animals are... period. (3) The actual concentrations of the test substance must be measured in the breathing...

  11. 40 CFR 799.9130 - TSCA acute inhalation toxicity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) Definitions. The definitions in section 3 of TSCA and the definitions in 40 CFR Part 792—Good Laboratory... 40 CFR part 792, subpart f. (3) Test procedures—(i) Preparation. Healthy young adult animals are... period. (3) The actual concentrations of the test substance must be measured in the breathing...

  12. 40 CFR 799.9410 - TSCA chronic toxicity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... morphological (pathological) effects. (c) Definitions. The definitions in section 3 of TSCA and in 40 CFR Part... unique identification number. Dead animals, their preserved organs and tissues, and microscopic slides... ulcers, fissures, exudate/crust(eschar), dead tissue, or anything leading to destruction of...

  13. 40 CFR 799.9410 - TSCA chronic toxicity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... morphological (pathological) effects. (c) Definitions. The definitions in section 3 of TSCA and in 40 CFR Part... unique identification number. Dead animals, their preserved organs and tissues, and microscopic slides... ulcers, fissures, exudate/crust(eschar), dead tissue, or anything leading to destruction of...

  14. 40 CFR 799.9130 - TSCA acute inhalation toxicity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) Definitions. The definitions in section 3 of TSCA and the definitions in 40 CFR Part 792—Good Laboratory... 40 CFR part 792, subpart f. (3) Test procedures—(i) Preparation. Healthy young adult animals are... period. (3) The actual concentrations of the test substance must be measured in the breathing...

  15. 40 CFR 799.9130 - TSCA acute inhalation toxicity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) Definitions. The definitions in section 3 of TSCA and the definitions in 40 CFR Part 792—Good Laboratory... 40 CFR part 792, subpart f. (3) Test procedures—(i) Preparation. Healthy young adult animals are... period. (3) The actual concentrations of the test substance must be measured in the breathing...

  16. 40 CFR 799.9410 - TSCA chronic toxicity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... morphological (pathological) effects. (c) Definitions. The definitions in section 3 of TSCA and in 40 CFR Part... unique identification number. Dead animals, their preserved organs and tissues, and microscopic slides... ulcers, fissures, exudate/crust(eschar), dead tissue, or anything leading to destruction of...

  17. 40 CFR 799.9130 - TSCA acute inhalation toxicity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) Definitions. The definitions in section 3 of TSCA and the definitions in 40 CFR Part 792—Good Laboratory... 40 CFR part 792, subpart f. (3) Test procedures—(i) Preparation. Healthy young adult animals are... period. (3) The actual concentrations of the test substance must be measured in the breathing...

  18. 40 CFR 799.9410 - TSCA chronic toxicity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... morphological (pathological) effects. (c) Definitions. The definitions in section 3 of TSCA and in 40 CFR Part... unique identification number. Dead animals, their preserved organs and tissues, and microscopic slides... ulcers, fissures, exudate/crust(eschar), dead tissue, or anything leading to destruction of...

  19. 40 CFR 799.9325 - TSCA 90-day dermal toxicity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of this study to humans is valid only to a limited degree. It can, however, provide useful... human exposure. (b) Source. The source material used in developing this TSCA test guideline is the... substance (grams, milligrams), per unit body weight of test animal (milligrams per kilogram), or as...

  20. 76 FR 38170 - Toxic Substances Control Act Chemical Testing; Receipt of Test Data

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... issue of March 16, 2006 (71 FR 13708) (FRL-7335-2). Section 4(d) of TSCA (15 U.S.C. 2603(d)) requires... Toxicity to Fish. 9. Acute Toxicity to Aquatic Invertebrates. 10. Toxicity to Aquatic Plants, e.g.,...

  1. 78 FR 64210 - Extension of Review Periods Under the Toxic Substances Control Act; Certain Chemicals and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-28

    .... Additionally, EPA did not receive notifications with respect to such submissions on or after October 1, 2013... during the shutdown did not begin until operations resumed on October 17, 2013. DATES: The duration of... any TSCA section 5 notice submitted during the shutdown did not begin until operations resumed...

  2. 40 CFR 799.9530 - TSCA in vitro mammalian cell gene mutation test.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 33 2012-07-01 2012-07-01 false TSCA in vitro mammalian cell gene... MIXTURE TESTING REQUIREMENTS Health Effects Test Guidelines § 799.9530 TSCA in vitro mammalian cell gene.... The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced...

  3. 40 CFR 799.9530 - TSCA in vitro mammalian cell gene mutation test.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 32 2011-07-01 2011-07-01 false TSCA in vitro mammalian cell gene... MIXTURE TESTING REQUIREMENTS Health Effects Test Guidelines § 799.9530 TSCA in vitro mammalian cell gene.... The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced...

  4. 40 CFR 799.9530 - TSCA in vitro mammalian cell gene mutation test.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 32 2014-07-01 2014-07-01 false TSCA in vitro mammalian cell gene... MIXTURE TESTING REQUIREMENTS Health Effects Test Guidelines § 799.9530 TSCA in vitro mammalian cell gene.... The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced...

  5. 40 CFR 799.9530 - TSCA in vitro mammalian cell gene mutation test.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 33 2013-07-01 2013-07-01 false TSCA in vitro mammalian cell gene... MIXTURE TESTING REQUIREMENTS Health Effects Test Guidelines § 799.9530 TSCA in vitro mammalian cell gene.... The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced...

  6. 40 CFR 799.6786 - TSCA water solubility: Generator column method.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... relatively water soluble are more likely to be widely distributed by the hydrologic cycle than those which... 40 Protection of Environment 31 2010-07-01 2010-07-01 true TSCA water solubility: Generator column... TESTING REQUIREMENTS Product Properties Test Guidelines § 799.6786 TSCA water solubility: Generator...

  7. Identifying new persistent and bioaccumulative organics among chemicals in commerce.

    PubMed

    Howard, Philip H; Muir, Derek C G

    2010-04-01

    The goal of this study was to identify commercial chemicals that might be persistent and bioaccumulative (P&B) and that were not being considered in current Great Lakes, North American, and Arctic contaminant measurement programs. We combined the Canadian Domestic Substance List (DSL), a list of 3059 substances of "unknown or variable composition complex reaction products and biological materials" (UVCBs), and the U.S. Environmental Protection Agency (U.S. EPA) Toxic Substances Control Act (TSCA) Inventory Update Rule (IUR) database for years 1986, 1990, 1994, 1998, 2002, and 2006 yielding a database of 22263 commercial chemicals. From that list, 610 chemicals were identified by estimates from U.S EPA EPISuite software and using expert judgment. This study has yielded some interesting and probable P&B chemicals that should be considered for further study. Recent studies, following up our initial reports and presentations on this work, have confirmed the presence of many of these chemicals in the environment.

  8. Overview of the regulation of hazardous chemicals: SDWA (Safe Drinking Water Act), RCRA (Resource Conservation and Recovery Act), and CERCLA (Comprehensive Environmental Response, Compensation, and Liability Act)

    SciTech Connect

    Baes, C.F. III

    1989-01-01

    The regulation of nonradioactive hazardous chemicals is carried out under a number of federal environmental laws that regulate either hazardous products, substances, or wastes. Because each law is intended to provide protection from different classes of substances (e.g., wastes vs products) or protect different media (e.g., air, water, land), the standards and levels of protection for different hazardous chemicals may be different. Nevertheless, one agency -- the Environmental Protection Agency (EPA) -- has primary responsibility for both promulgating regulations mandated by Congress under the various statutes and enforcement of the regulations. One overriding principal underlies the maze of complex regulations that govern the transport, treatment, storage, and disposal of hazardous substances: protect human health and the environment. It is beyond the scope of this talk to comprehensively examine all of the regulations and standards that govern the management of hazardous chemicals. Instead this discussion will focus on three statutes, the Safe Drinking Water Act (SDWA), the Resource Conservation and Recovery Act (RCRA), and the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), that together provide a basis for a basic understanding of the approach that the EPA takes to regulating hazardous chemicals.

  9. Stabilization/solidification of TSCA incinerator ash

    SciTech Connect

    Spence, R.D.; Trotter, D.R.; Francis, C.L.; Morgan, I.L.

    1994-06-01

    Stabilization/solidification is a well-known waste treatment technique that utilizes different additives and processes. The Phoenix Ash Technology of the Technical Innovation Development Engineering Company is such a technique that uses Cass C fly ash and mechanical pressure to make brick waste forms out of solid wastes, such as the bottom ash from the Toxic Substances Control Act incinerator at the Oak Ridge K-25 Site. One advantage of this technique is that no volume increase over the bulk volume of the bottom ash occurs. This technique should have the same high pH stabilization for Resource Conservation and Recovery Act metals as similar techniques. Also, consolidation of the bottom ash minimizes the potential problems of material dispersion and container corrosion. The bottom ash was spiked with {sup 99}{Tc} to test the effectiveness of the bricks as a physical barrier. The {sup 99}{Tc} leachability index measured for these bricks was 6.8, typical for the pertechnetate anion in cementitious waste forms, indicating that these bricks have accessible porosity as high as that of other cementitious waste forms, despite the mechanical compression, higher waste form density, and water resistant polymer coating.

  10. 40 CFR 799.9537 - TSCA in vitro mammalian chromosome aberration test.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... The definitions in section 3 of TSCA and in 40 CFR Part 792—Good Laboratory Practice Standards apply...-103 (1982). (16) Zamora, P.O. et al. Evaluation of an Exposure System Using Cells Grown on...

  11. 40 CFR 799.9537 - TSCA in vitro mammalian chromosome aberration test.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .... The definitions in section 3 of TSCA and in 40 CFR Part 792—Good Laboratory Practice Standards apply... Exposure System Using Cells Grown on Collagen Gels for Detecting Highly Volatile Mutagens in the...

  12. 78 FR 69414 - Toxic Substances Control Act Chemical Testing; Receipt of Test Data

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... October 21, 2011 (76 FR 65385) (FRL-8885-5) (docket ID number EPA-HQ-OPPT-2009-0112). The table in this... AGENCY Toxic Substances Control Act Chemical Testing; Receipt of Test Data AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: This notice announces EPA's receipt of test data on...

  13. Title III (SARA and Clean Air Act Amendments) Emergency Planning and Community Right-to-Know Act and accidental release prevention consolidated chemical list (for microcomputers). Data file

    SciTech Connect

    1995-04-01

    This consolidated chemical list includes chemicals subject to reporting requirements under Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA), also known as the Emergency Planning and Community Right-to-Know Act (EPCRA), and chemicals listed under section 112(r) of Title III of the Clean Air Act (CAA) Amendments of 1990. This consolidated list has been prepared to help firms handling chemicals determine whether they need to submit reports under sections 302, 304, or 313 of SARA Title III (EPCRA) and, for a specific chemical, what reports may need to be submitted. It will also help firms determine wether they will be subject to accident prevention regulations under CAA section 112(r). Separate lists are also provided of Resource Conservation and Recovery Act (RCRA) waste streams and unlisted hazardous wastes, and of radionuclides reportable under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). These lists should be used as a reference tool, not as a definitive source of compliance information. Compliance information for EPCRA is published in the Code of Federal Regulations (CFR), 40 CFR Parts 302, 355, and 372. Compliance information for CAA section 112(r) will be published in 40 CFR Part 68. This revision reflects regulatory changes through December 1994. The chemicals on the consolidated list are ordered by Chemical Abstract Service (CAS) registry number. Categories of chemicals, which do not have CAS registry numbers, but which are cited under CERCLA, EPCRA section 313, and the CAA, are placed at the end of the list. For reference purposes, the chemicals (with their CAS numbers) are ordered alphabetically following the CAS-order list. Long chemical names may have been truncated to facilitate printing of this list. The list includes chemicals referenced under five federal statutory provisions.

  14. Evaluation of a Fourier transform infrared continuous emission monitor field test at a TSCA incinerator

    SciTech Connect

    Mao, Z.; Demirgian, J.C.; Reedy, G.

    1994-06-01

    A Fourier transform infrared (FTIR) spectrometer was field tested as a continuous emission monitor (CEM) at the Toxic Substances Control Act (TSCA) incinerator at K-25 in Oak Ridge, Tenn., from August 23 to September 3, 1993. This paper reports results obtained from this field test. The FTIR spectrometer and the long-path cell used for the field test were specially designed and constructed, so that optical alignment of the system can be easily performed in the field. The system was tested in the laboratory and then in the field for instrument stability and signal-to-noise ratio. Time interval required for taking a new background spectrum was determined. It appears that the system performs well both in the laboratory and in the field. The field test followed a standard operation procedure (SOP), developed for the test, based on a proposed EPA protocol for applying FTIR in emission testing. Sixteen compounds were selected as target analytes. Ethylene was used as a calibration transfer standard to ensure that spectral performance of the FTIR spectrometer in the field is consistent with that in the laboratory. Spike tests were regularly conducted with a known concentration of a mixture of six compounds and also with SF{sub 6} to check the accuracy of the monitoring system. Data sampling, processing, and reporting were automated to collect data every 10 min, and data were collected throughout the test as long as liquid nitrogen was available in the detector. The instrumentation and software performed flawlessly. Although the field test was a success, further improvement is necessary. Suggestions for revising the SOP and the proposed EPA protocol are discussed.

  15. 77 FR 34777 - Seventieth Report of the TSCA Interagency Testing Committee to the Administrator of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... Administrator every 6 months even if there are no changes to the TSCA section 4(e) Priority Testing List. In the... section 4(e) Priority Testing List. DATES: Comments must be received on or before July 11, 2012. ADDRESSES... the following methods: Federal eRulemaking Portal: http://www.regulations.gov . Follow the...

  16. 40 CFR 799.9305 - TSCA Repeated dose 28-day oral toxicity study in rodents.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... indication of immunological effects and reproductive organ toxicity. (c) Definitions. The definitions in section 3 of TSCA and in 40 CFR Part 792—Good Laboratory Practice Standards apply to this section. The... strains of young healthy adult animals should be employed. The females should be nulliparous and...

  17. 40 CFR 799.9355 - TSCA reproduction/developmental toxicity screening test.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... information concerning the effects of a test substance on male and female reproductive performance such as... the reproductive system. The number of implantation sites should be recorded. Corpora lutea should be...) Definitions. The definitions in section 3 of TSCA and in 40 CFR Part 792—Good Laboratory Practice...

  18. 40 CFR 799.9355 - TSCA reproduction/developmental toxicity screening test.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... information concerning the effects of a test substance on male and female reproductive performance such as... the reproductive system. The number of implantation sites should be recorded. Corpora lutea should be...) Definitions. The definitions in section 3 of TSCA and in 40 CFR Part 792—Good Laboratory Practice...

  19. 40 CFR 799.9305 - TSCA Repeated dose 28-day oral toxicity study in rodents.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... indication of immunological effects and reproductive organ toxicity. (c) Definitions. The definitions in section 3 of TSCA and in 40 CFR Part 792—Good Laboratory Practice Standards apply to this section. The... strains of young healthy adult animals should be employed. The females should be nulliparous and...

  20. 40 CFR 799.9305 - TSCA Repeated dose 28-day oral toxicity study in rodents.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... indication of immunological effects and reproductive organ toxicity. (c) Definitions. The definitions in section 3 of TSCA and in 40 CFR Part 792—Good Laboratory Practice Standards apply to this section. The... strains of young healthy adult animals should be employed. The females should be nulliparous and...

  1. 40 CFR 799.9305 - TSCA Repeated dose 28-day oral toxicity study in rodents.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... indication of immunological effects and reproductive organ toxicity. (c) Definitions. The definitions in section 3 of TSCA and in 40 CFR Part 792—Good Laboratory Practice Standards apply to this section. The... strains of young healthy adult animals should be employed. The females should be nulliparous and...

  2. 40 CFR 799.9355 - TSCA reproduction/developmental toxicity screening test.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... information concerning the effects of a test substance on male and female reproductive performance such as... the reproductive system. The number of implantation sites should be recorded. Corpora lutea should be...) Definitions. The definitions in section 3 of TSCA and in 40 CFR Part 792—Good Laboratory Practice...

  3. 40 CFR 799.9355 - TSCA reproduction/developmental toxicity screening test.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... information concerning the effects of a test substance on male and female reproductive performance such as... the reproductive system. The number of implantation sites should be recorded. Corpora lutea should be...) Definitions. The definitions in section 3 of TSCA and in 40 CFR Part 792—Good Laboratory Practice...

  4. 40 CFR 799.9355 - TSCA reproduction/developmental toxicity screening test.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... information concerning the effects of a test substance on male and female reproductive performance such as... the reproductive system. The number of implantation sites should be recorded. Corpora lutea should be...) Definitions. The definitions in section 3 of TSCA and in 40 CFR Part 792—Good Laboratory Practice...

  5. 40 CFR 799.9537 - TSCA in vitro mammalian chromosome aberration test.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... The definitions in section 3 of TSCA and in 40 CFR Part 792—Good Laboratory Practice Standards apply... after an S period of DNA replication, the nucleus does not go into mitosis but starts another S period... other than direct DNA damage. (e) Principle of the test method. Cell cultures are exposed to the...

  6. 78 FR 48845 - Hydrofluorosilicic Acid in Drinking Water; TSCA Section 21 Petition; Reasons for Agency Response

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-12

    .... Association of silicofluoride treated water with elevated blood lead. Neurotoxicology. Vol. 21, pp. 1091-1099... Copper; Final Rule. Federal Register (56 FR 26460, June 7, 1991). 12. American Water Works Association... AGENCY 40 CFR Chapter I Hydrofluorosilicic Acid in Drinking Water; TSCA Section 21 Petition; Reasons...

  7. 40 CFR 799.6784 - TSCA water solubility: Column elution method; shake flask method.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... temperature. (iii) Flask method: Test procedure. The quantity of material necessary to saturate the desired... source material used in developing this TSCA test guideline is the Office of Pollution Prevention... tested and the test temperatures; it ranges from 0.05 to 0.34 for the column elution method, and from...

  8. 75 FR 70246 - Lead Fishing Sinkers; Disposition of TSCA Section 21 Petition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ... Lead in Bullets and Shot As discussed in the Federal Register of September 24, 2010 (75 FR 58377) (FRL... one the Agency, as reflected in its proposal, found to be appropriate even then. (59 FR 11122, March 9... AGENCY Lead Fishing Sinkers; Disposition of TSCA Section 21 Petition AGENCY: Environmental...

  9. Request for interim approval to operate Trench 94 of the 218-E-12B Burial Ground as a chemical waste landfill for disposal of polychlorinated biphenyl waste in submarine reactor compartments. Revision 2

    SciTech Connect

    Cummins, G.D.

    1994-06-01

    This request is submitted to seek interim approval to operate a Toxic Substances Control Act (TSCA) of 1976 chemical waste landfill for the disposal of polychlorinated biphenyl (PCB) waste. Operation of a chemical waste landfill for disposal of PCB waste is subject to the TSCA regulations of 40 CFR 761. Interim approval is requested for a period not to exceed 5 years from the date of approval. This request covers only the disposal of small 10 quantities of solid PCB waste contained in decommissioned, defueled submarine reactor compartments (SRC). In addition, the request applies only to disposal 12 of this waste in Trench 94 of the 218-E-12B Burial Ground (Trench 94) in the 13 200 East Area of the US Department of Energy`s (DOE) Hanford Facility. Disposal of this waste will be conducted in accordance with the Compliance 15 Agreement (Appendix H) between the DOE Richland Operations Office (DOE-RL) and 16 the US Environmental Protection Agency (EPA), Region 10. During the 5-year interim approval period, the DOE-RL will submit an application seeking final 18 approval for operation of Trench 94 as a chemical waste landfill, including 19 any necessary waivers, and also will seek a final dangerous waste permit from 20 the Washington State Department of Ecology (Ecology) for disposal of lead 21 shielding contained in the SRCS.

  10. Advances in Exposure Science (Washington, DC Modernized TSCA meeting)

    EPA Science Inventory

    I am describing current research from the Chemical Safety for Sustainability research program's Rapid Exposure and Dosimetry project that relates to predicting human exposure to environmental chemicals for thousands of chemicals.

  11. 40 CFR 711.6 - Chemical substances for which information is not required.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) developed under the procedures of 40 CFR part 790, or is the subject of an order issued under TSCA section 5... living organism, and that meets the definition of microorganism at 40 CFR 725.3. Any chemical substance... occurring chemical substances. Any naturally occurring chemical substance, as described in 40 CFR...

  12. 1992 Toxic Chemical Release Inventory: Emergency Planning and Community Right-To-Know-Act of 1986 Section 313

    SciTech Connect

    Not Available

    1993-07-01

    Section 313 of the Emergency Planning and Community Right-To-Know Act of 1986 (EPCRA) requires the annual submittal of toxic chemical release information to the US Environmental Protection Agency (EPA). The following document is the July 1993 submittal of the EPCRA Toxic Chemical Release Inventory Report (Form R). Included is a Form R for chlorine and for lead, the two chemicals used in excess of the established regulatory thresholds at the Hanford Site by the US Department of Energy, Richland Operations Office and its contractors during calendar year 1992.

  13. A toxicokinetic study of specifically acting and reactive organic chemicals for the prediction of internal effect concentrations in Scenedesmus vacuolatus.

    PubMed

    Vogs, Carolina; Kühnert, Agnes; Hug, Christine; Küster, Eberhard; Altenburger, Rolf

    2015-01-01

    The toxic potency of chemicals is determined by using the internal effect concentration by accounting for differences in toxicokinetic processes and mechanisms of toxic action. The present study examines toxicokinetics of specifically acting and reactive chemicals in the green algae Scenedesmus vacuolatus by using an indirect method. Concentration depletion in the exposure medium was measured for chemicals of lower (log KOW  < 3: isoproturon, metazachlor, paraquat) and moderate (log KOW 4-5: irgarol, triclosan, N-phenyl-2-naphthylamine) hydrophobicity at 7 to 8 time points over 240 min or 360 min. Uptake and overall elimination rates were estimated by fitting a toxicokinetic model to the observed concentration depletions. The equilibrium of exposure concentrations was reached within minutes to hours or was even not observed within the exposure time. The kinetics of bioconcentration cannot be explained by the chemical's hydrophobicity only, but influential factors such as ionization of chemicals, the ion trapping mechanism, or the potential susceptibility for biotransformation are discussed. Internal effect concentrations associated with 50% inhibition of S. vacuolatus reproduction were predicted by linking the bioconcentration kinetics to the effect concentrations and ranged from 0.0480 mmol/kg wet weight to 7.61 mmol/kg wet weight for specifically acting and reactive chemicals. Knowing the time-course of the internal effect concentration may promote an understanding of toxicity processes such as delayed toxicity, carry-over toxicity, or mixture toxicity in future studies.

  14. Title III list of lists: Consolidated list of chemicals subject to the Emergency Planning and Community Right-to-Know Act (EPCRA) and section 112(r) of the Clean Air Act, as amended. Title III of the Superfund Amendments and Reauthorization Act of 1986, and Title III of the Clean Air Act Amendments of 1990

    SciTech Connect

    Not Available

    1994-06-01

    The consolidated chemical list includes chemicals subject to reporting requirements under Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA), also known as the Emergency Planning and Community Right-to-Know Act (EPCRA), and chemicals listed under section 112(r) of Title III the Clean Air Act (CAA) Amendments of 1990. This consolidated list has been prepared to help firms handling chemicals determine whether they need to submit reports under sections 302, 304, or 313 of SARA Title III (EPCRA) and, for a specific chemical, what reports may need to be submitted. Separate lists are also provided of Resource Conservation and Recovery Act (RCRA) waste streams and unlisted hazardous wastes, and of radionuclides reportable under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). These lists should be used as reference tool, not as a definitive source of compliance information. The chemicals on the consolidated list are ordered by Chemical Abstract Service (CAS) registry number. Categories of chemicals, which do not have CAS registry numbers, but which are cited under CERCLA, EPCRA section 313, and the CAA, are placed at the end of the list. More than one chemical name may be listed for one CAS number, because the same chemical may appear on different lists under different names.

  15. 2008 Toxic Chemical Release Inventory 2008 Toxic Chemical Release Inventory Community Right-to-Know Act of 1986, Title III, Section 313

    SciTech Connect

    Ecology and Air Quality Group

    2009-10-01

    For reporting year 2008, Los Alamos National Laboratory (LANL) submitted a Form R report for lead as required under the Emergency Planning and Community Right-to- Know Act (EPCRA) Section 313. No other EPCRA Section 313 chemicals were used in 2008 above the reportable thresholds. This document was prepared to provide a description of the evaluation of EPCRA Section 313 chemical use and threshold determinations for LANL for calendar year 2008, as well as to provide background information about data included on the Form R reports. Section 313 of EPCRA specifically requires facilities to submit a Toxic Chemical Release Inventory Report (Form R) to the U.S. Environmental Protection Agency (EPA) and state agencies if the owners and operators manufacture, process, or otherwise use any of the listed toxic chemicals above listed threshold quantities. EPA compiles this data in the Toxic Release Inventory database. Form R reports for each chemical over threshold quantities must be submitted on or before July 1 each year and must cover activities that occurred at the facility during the previous year. In 1999, EPA promulgated a final rule on persistent bioaccumulative toxics (PBTs). This rule added several chemicals to the EPCRA Section 313 list of toxic chemicals and established lower reporting thresholds for these and other PBT chemicals that were already reportable. These lower thresholds became applicable in reporting year 2000. In 2001, EPA expanded the PBT rule to include a lower reporting threshold for lead and lead compounds. Facilities that manufacture, process, or otherwise use more than 100 lb of lead or lead compounds must submit a Form R.

  16. 78 FR 66700 - Toxic Substances Control Act Chemical Testing; Receipt of Test Data

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-06

    ... FR 13708) (FRL-7335-2) (docket identification (ID) number EPA-HQ-OPPT-2005-0033). EPA received data... (76 FR 1067) (FRL-8846-9) (docket ID number EPA-HQ-OPPT-2007-0531). EPA received data on 5 chemicals...; Third Group of Chemicals,'' published in the Federal Register issue of October 21, 2011 (76 FR...

  17. 75 FR 5405 - Sixty-Fifth Report of the TSCA Interagency Testing Committee to the Administrator of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-02

    ..., which is included with this notice, the ITC has no revisions to the TSCA section 4(e) Priority Testing... methods: Federal eRulemaking Portal: http://www.regulations.gov . Follow the on-line instructions for... or otherwise protected through regulations.gov or e- mail. The regulations.gov website is...

  18. 75 FR 42441 - Sixty-Sixth Report of the TSCA Interagency Testing Committee to the Administrator of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-21

    ... Federal Register issue of February 25, 2010 (75 FR 8575) (FRL-8805-8) available on-line at http://www.gpoaccess.gov/fr . III. The TSCA Interagency Testing Committee Statutory Organizations and Their... Recommended (mixed isomers) 41 November 1997 Phenol, 4-(1,1,3,3- Recommended tetramethylbutyl)- 55...

  19. 40 CFR 799.9539 - TSCA mammalian erythrocyte micronucleus test.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... not be suspected of chemical reaction with the test substance. If other than well-known solvents... positive result, such as a dose-related increase in the number of micronucleated cells or a clear increase... study. (D) Stability of the test substance, if known. (ii) Solvent/vehicle: (A) Justification......

  20. Title III List of Lists: Consolidated list of chemicals subject to the Emergency Planning and Community Right-to-Know Act (EPCRA) and Section 112(r) of the Clean Air Act, as amended. Title III of the Superfund Amendments and Reauthorization Act of 1986, and Title III of the Clean Air Act Amendments of 1990

    SciTech Connect

    1996-12-01

    This consolidated chemical list includes chemicals subject to reporting requirements under Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA), also known as the Emergency Planning and Community Right-to-Know Act (EPCRA) and chemicals listed under Section 112(r) of Title III of the Clean Air Act (CAA) Amendments of 1990. This consolidated list has been prepared to help firms handling chemicals determine whether they need to submit reports under sections 302, 304, or 314 or SARA Title III (EPCRA) and, for a specific chemical, what reports may need to be submitted. It also will also help firms determine whether they will be subject to accident prevention regulations under CAA section 112(r).

  1. 75 FR 3462 - Claims of Confidentiality of Certain Chemical Identities Submitted under Section 8(e) of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ... AGENCY Claims of Confidentiality of Certain Chemical Identities Submitted under Section 8(e) of the Toxic... announcing a new general practice of reviewing submissions under section 8(e) of the Toxic Substances Control... section 8(e) of TSCA involves a chemical identity that is already listed on the public portion of the...

  2. 1993 Toxic Chemical Release Inventory: Emergency Planning and Community Right-To-Know Act of 1986, Section 313

    SciTech Connect

    Not Available

    1994-07-01

    Section 313 of the Emergency Planning and Community Right-To-Know-Act of 1986 (EPCRA) requires the annual submittal of toxic chemical release information to the US Environmental Protection Agency. The following document is the July 1994 submittal of the Hanford site EPCRA Toxic Chemical Release Inventory (TRI) Report. Included is a Form R for chlorine, the sole chemical used in excess of the established regulatory thresholds at the Hanford Site by the US Department of Energy, Richland Operations Office and its contractors during Calendar Year 1993. Only those facilities that fall within the Standard Industrial Classification (SIC) code range of 20 through 39 are subject to mandatory reporting under EPCRA, Section 313. However, on August 3, 1993, Executive Order 12856 was signed, requiring all federal agencies and facilities to comply with pollution prevention and emergency planning and community right-to-know provisions established by Section 313 of EPCRA and Section 6607 of the Pollution Prevention Act of 1990, without restriction to the specified SIC Codes. The report format requires identification of the facility SIC Code in the TRI Report. Application of definitions and requirements provided in Title 40, Code of Federal Regulations Part 372.22 has led to the adoption of SIC Code 9999, Nonclassifiable Establishments, as the primary Hanford Site SIC Code for EPCRA regulatory assessments. The SIC Code 9999 determination is based on a broad analysis of the current mission of the Hanford Site which includes environmental and waste management, demonstration and application of advanced remediation technologies, and environmental restoration.

  3. 1997 toxic chemical release inventory -- Emergency Planning and Community Right-To-Know Act, Section 313

    SciTech Connect

    Zaloudek, D.E.

    1998-06-30

    Two listed toxic chemicals were used at the Hanford Site above established activity thresholds: phosphoric acid and chlorine. Because total combined quantities of chlorine released, disposed, treated, recovered through recycle operations, co-combusted for energy recovery, and transferred to off-site locations for the purpose of recycle, energy recovery, treatment, and/or disposal, amounted to less than 500 pounds, the Hanford Site qualified for the alternate one million pound threshold for chlorine. Accordingly, this Toxic Chemical Release Inventory includes a Form A for chlorine, and a Form B for phosphoric acid.

  4. 77 FR 4947 - Proposed Significant New Use Rules on Certain Chemical Substances; Reopening of Comment Period

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ... in the Federal Register of December 28, 2011 (76 FR 81447) (FRL-9326-2). In that document, EPA...: Kenneth Moss, Chemical Control Division (7405M), Office of Pollution Prevention and Toxics, Environmental...; email address: moss.kenneth@epa.gov . For general information contact: The TSCA-Hotline,...

  5. [Logistic preparedness of chosen urban agglomeration hospitals to act during massive chemical disasters].

    PubMed

    Burda, Piotr; Sein Anand, Jacek; Chodorowski, Zygmunt; Groszek, Barbara

    2007-01-01

    Twelve hospitals--five form Warsaw, three from Kraków, and four from Gdańsk and Gdynia were randomized for the study. The logistic preparedness of hospitals during massive chemical accidents has been investigated. There were 146 probands (9 managers, 31 ward heads, 75 assistants and 31 ward nurses) included in the study. In statistical analysis the generalized linear model extended by random factors, particularly the Poisson's regression has been used. No hospital in the three big cities in the country was prepared for any logistic action in case of massive chemical disaster. There were no stationary and mobile decontamination units in the investigated hospitals. There was no individual protective equipment in any of the analyzed hospitals. There were serious deficits in assortment and amount of antidotes which can be used in the treatment of contaminated patients. As much as 97.2% of respondents pointed the poison information centers as a main source of information in case of chemical accidents.

  6. 76 FR 54932 - TSCA Inventory Update Reporting Modifications; Chemical Data Reporting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-06

    ... Product 8002-05-9 Petroleum. 8002-74-2 Paraffin waxes and hydrocarbon waxes. 8006-20-0 Fuel gases, low and...-4 Asphalt. 61789-60-4 Pitch. 63231-60-7 Paraffin waxes and hydrocarbon waxes, microcryst. 64741-41-9...), acid- treated spent. 64742-26-3 Hydrocarbon waxes (petroleum), acid- treated. 64742-27-4...

  7. 78 FR 67141 - Antimony Trioxide (ATO) TSCA Chemical Risk Assessment; Notice of Public Meetings and Opportunity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ... To Comment AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: On September 27... Pollution Prevention and Toxics, Environmental Protection Agency, 1200 Pennsylvania Ave. NW., Washington, DC... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL...

  8. 78 FR 34377 - Trichloroethylene TSCA Chemical Risk Assessment; Notice of Public Meetings and Opportunity to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-07

    .... Background On January 9, 2013, EPA published a notice in the Federal Register (78 FR 1856) (FRL-9375-1) on... appearance of conflict of interest exists for any proposed peer review panel expert. DATES: Meetings. The..., 2013. Conflict of interest comments. Comments on the appearance of a conflict of interest for...

  9. 77 FR 15609 - Revocation of TSCA Section 4 Testing Requirements for Certain High Production Volume Chemical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-16

    ... Register (71 FR 13708, March 16, 2006) (FRL-7335-2). (Document ID number EPA-HQ-OPPT-2005-0033-0001). 2..., Substantial Release, and Substantial or Significant Human Exposure; Notice. Federal Register (58 FR 28736, May... regulatory action'' under Executive Order 12866, entitled ``Regulatory Planning and Review'' (58 FR...

  10. 77 FR 36170 - TSCA Inventory Update Reporting Modifications; Chemical Data Reporting; 2012 Submission Period...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-18

    ... Environmental Health Risks and Safety Risks'' (62 FR 19885, April 23, 1997) and Executive Order 13211 entitled... Reporting; 2012 Submission Period Extension AGENCY: Environmental Protection Agency (EPA). ACTION: Final... electronically through http://www.regulations.gov or in hard copy at the Pollution Prevention and Toxics...

  11. Recovery Act: Novel Oxygen Carriers for Coal-fueled Chemical Looping

    SciTech Connect

    Pan, Wei-Ping; Cao, Yan

    2012-11-30

    Chemical Looping Combustion (CLC) could totally negate the necessity of pure oxygen by using oxygen carriers for purification of CO{sub 2} stream during combustion. It splits the single fuel combustion reaction into two linked reactions using oxygen carriers. The two linked reactions are the oxidation of oxygen carriers in the air reactor using air, and the reduction of oxygen carriers in the fuel reactor using fuels (i.e. coal). Generally metal/metal oxides are used as oxygen carriers and operated in a cyclic mode. Chemical looping combustion significantly improves the energy conversion efficiency, in terms of the electricity generation, because it improves the reversibility of the fuel combustion process through two linked parallel processes, compared to the conventional combustion process, which is operated far away from its thermo-equilibrium. Under the current carbon-constraint environment, it has been a promising carbon capture technology in terms of fuel combustion for power generation. Its disadvantage is that it is less mature in terms of technological commercialization. In this DOE-funded project, accomplishment is made by developing a series of advanced copper-based oxygen carriers, with properties of the higher oxygen-transfer capability, a favorable thermodynamics to generate high purity of CO{sub 2}, the higher reactivity, the attrition-resistance, the thermal stability in red-ox cycles and the achievement of the auto-thermal heat balance. This will be achieved into three phases in three consecutive years. The selected oxygen carriers with final-determined formula were tested in a scaled-up 10kW coal-fueled chemical looping combustion facility. This scaled-up evaluation tests (2-day, 8-hour per day) indicated that, there was no tendency of agglomeration of copper-based oxygen carriers. Only trace-amount of coke or carbon deposits on the copper-based oxygen carriers in the fuel reactor. There was also no evidence to show the sulphidization of oxygen

  12. Title III list of lists: Consolidated list of chemicals subject to the Emergency Planning and Community Right-to-Know Act (EPCRA) and section 112(r) of the Clean Air Act, as ammended. Title III of the Superfund Amendments and Reauthorization Act of 1986, and Title III of the Clean Air Act Amendments of 1990, April 1995

    SciTech Connect

    1995-04-01

    This consolidated list has been prepared to help firms handling chemicals determine whether they need to submit reports under sections 302, 304, or 313 of SARA Title III (EPCRA) and, for a specific chemical, what reports may need to be submitted. It will also help firms determine whether they will be subject to accident prevention regulations under CAA section 112(r). Separate lists are also provided of Resource Conservation and Recovery Act (RCRA) waste streams and unlisted hazardous wastes, and of radionuclides reportable under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). These lists should be used as a reference tool, not as a definitive source of compliance information.

  13. Consolidated list of chemicals subject to reporting under the Emergency Planning and Community Right-to-Know Act. (Title III of the Superfund Amendments and Reauthorization Act of 1986)

    SciTech Connect

    Not Available

    1992-01-01

    The consolidated chemical list includes chemicals subject to reporting requirements under Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA), also known as the Emergency Planning and Community Right-to-Know Act (EPCRA). It has been prepared to help firms handling chemicals determine whether they need to submit reports under sections 302, 304, or 313 of Title III and, for a specific chemical, what reports may need to be submitted. Separate lists are also provided of RCRA waste streams and unlisted hazardous wastes, and of radionuclides reportable under CERCLA. The lists should be used as a reference tool, not as a definitive source of compliance information. Compliance information is published in the Code of Federal Regulations, 40 CFR Parts 302, 355, and 372. The chemicals on the consolidated list are ordered by Chemical Abstract Service (CAS) registry number. Categories of chemicals, which do not have CAS registry numbers, but which are cited under CERCLA and section 313, are placed at the end of the list. For reference purposes, the chemicals (with their CAS numbers) are ordered alphabetically following the CAS-order list. Long chemical names may have been truncated to facilitate printing of the list.

  14. Abcb4 acts as multixenobiotic transporter and active barrier against chemical uptake in zebrafish (Danio rerio) embryos

    PubMed Central

    2013-01-01

    Background In mammals, ABCB1 constitutes a cellular “first line of defense” against a wide array of chemicals and drugs conferring cellular multidrug or multixenobiotic resistance (MDR/MXR). We tested the hypothesis that an ABCB1 ortholog serves as protection for the sensitive developmental processes in zebrafish embryos against adverse compounds dissolved in the water. Results Indication for ABCB1-type efflux counteracting the accumulation of chemicals in zebrafish embryos comes from experiments with fluorescent and toxic transporter substrates and inhibitors. With inhibitors present, levels of fluorescent dyes in embryo tissue and sensitivity of embryos to toxic substrates were generally elevated. We verified two predicted sequences from zebrafish, previously annotated as abcb1, by cloning; our synteny analyses, however, identified them as abcb4 and abcb5, respectively. The abcb1 gene is absent in the zebrafish genome and we explored whether instead Abcb4 and/or Abcb5 show toxicant defense properties. Quantitative real-time polymerase chain reaction (qPCR) analyses showed the presence of transcripts of both genes throughout the first 48 hours of zebrafish development. Similar to transporter inhibitors, morpholino knock-down of Abcb4 increased accumulation of fluorescent substrates in embryo tissue and sensitivity of embryos toward toxic compounds. In contrast, morpholino knock-down of Abcb5 did not exert this effect. ATPase assays with recombinant protein obtained with the baculovirus expression system confirmed that dye and toxic compounds act as substrates of zebrafish Abcb4 and inhibitors block its function. The compounds tested comprised model substrates of human ABCB1, namely the fluorescent dyes rhodamine B and calcein-am and the toxic compounds vinblastine, vincristine and doxorubicin; cyclosporin A, PSC833, MK571 and verapamil were applied as inhibitors. Additionally, tests were performed with ecotoxicologically relevant compounds: phenanthrene (a

  15. Common synonyms: For chemicals listed under section 313 of the Emergency Planning and Community Right-to-Know Act, March 1995

    SciTech Connect

    1995-03-01

    This glossary contains chemical names and synonyms for substances covered by the reporting requirements of section 313 of the Emergency Planning and Community Right-to-Know Act (EPCRA) (Title III of the Superfund Amendments and Reauthorization Act (SARA)) (40 CFR Part 372). Part I is a listing in Chemical Abstracts Service (CAS) registry number order. The CAS number is followed by the name by which the chemical is listed under section 313. Chemicals should be reported to TRI by their listing names. Each CAS number and associated listing name is followed by synonyms in alphabetical order. Part II of the glossary is an alphabetical list of chemical names and synonyms, with CAS numbers. In this list, section 313 names are followed by an asterisk and are footnoted as listing names.

  16. Two brominated cyclic dipeptides released by the coldwater marine sponge Geodia barretti act in synergy as chemical defense.

    PubMed

    Sjögren, Martin; Jonsson, Per R; Dahlström, Mia; Lundälv, Tomas; Burman, Robert; Göransson, Ulf; Bohlin, Lars

    2011-03-25

    The current work shows that two structurally similar cyclodipeptides, barettin (1) and 8,9-dihydrobarettin (2), produced by the coldwater marine sponge Geodia barretti Bowerbank act in synergy to deter larvae of surface settlers and may also be involved in defense against grazers. Previously, 1 and 2 were demonstrated to bind specifically to serotonergic 5-HT receptors. It may be suggested that chemical defense in G. barretti involves a synergistic action where one of the molecular targets is a 5-HT receptor. A mixture of 1 and 2 lowered the EC(50) of larval settlement as compared to the calculated theoretical additive effect of the two compounds. Moreover, an in situ sampling at 120 m depth using a remotely operated vehicle revealed that the sponge releases these two compounds to the ambient water. Thus, it is suggested that the synergistic action of 1 and 2 may benefit the sponge by reducing the expenditure of continuous production and release of its chemical defense substances. Furthermore, a synergistic action between structurally closely related compounds produced by the same bioenzymatic machinery ought to be the most energy effective for the organism and, thus, is more common than synergy between structurally indistinct compounds.

  17. Results of Hazardous and Mixed Waste Excavation from the Chemical Waste Landfill

    SciTech Connect

    Young, S. G.; Schofield, D. P.; Kwiecinski, D.; Edgmon, C. L.; Methvin, R.

    2002-02-27

    This paper describes the results of the excavation of a 1.9-acre hazardous and mixed waste landfill operated for 23 years at Sandia National Laboratories, Albuquerque, New Mexico. Excavation of the landfill was completed in 2 1/2 years without a single serious accident or injury. Approximately 50,000 cubic yards of soil contaminated with volatile and semi-volatile organics, metals, polychlorinated biphenyl compounds, and radioactive constituents was removed. In addition, over 400 cubic yards of buried debris was removed, including bulk debris, unknown chemicals, compressed gas cylinders, thermal and chemical batteries, explosive and ordnance debris, pyrophoric materials and biohazardous waste. Removal of these wastes included negotiation of multiple regulations and guidances encompassed in the Resource Conservation and Recovery Act (RCRA), the Toxic Substances Control Act (TSCA), and risk assessment methodology. RCRA concepts that were addressed include the area of contamination, permit modification, emergency treatment provision, and listed waste designation. These regulatory decisions enabled the project to overcome logistical and programmatic needs such as increased operational area, the ability to implement process improvements while maintaining a record of decisions and approvals.

  18. 1997 Toxic Chemical Release Inventory Report for the Emergency Planning and Community Right-to-Know Act of 1986, Title III, Section 313

    SciTech Connect

    Heather McBride

    1997-07-01

    The Emergency Planning and Community Right-to-Know Act of 1986 (EPCIL4), Title III, Section 313 [also known as the Superfund Amendment and Reauthorization Act (SARA)], as modified by Executive Order 12856, requires all federal facilities to submit an annual Toxic Chemical Release Inventory report every July for the preceding calendar year. Owners and operators of manufacturing, processing, or production facilities are required to report their toxic chemical releases to all environmental mediums (air, water, soil, etc.). At Los Alamos National Laboratory (LANL), nitric acid was the only toxic chemical used in 1997 that met the reportable threshold limit of 10,000 lb. Form R is the only documentation required by the Environmental Protection Agency, and it is included in the appendix of this report. This report, as requested by DOE, is provided for documentation purposes. In addition, a detailed description of the evaluation and reporting process for chemicals and processes at LANL has been included.

  19. Chemical Safety Improvement Act

    THOMAS, 113th Congress

    Sen. Lautenberg, Frank R. [D-NJ

    2013-05-22

    02/04/2014 Committee on Environment and Public Works Subcommittee on Water and Wildlife. Hearings held. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  20. Secure Chemical Facilities Act

    THOMAS, 113th Congress

    Sen. Lautenberg, Frank R. [D-NJ

    2013-01-23

    01/23/2013 Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  1. Secure Chemical Facilities Act

    THOMAS, 112th Congress

    Sen. Lautenberg, Frank R. [D-NJ

    2011-03-31

    03/31/2011 Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  2. Secure Chemical Facilities Act

    THOMAS, 111th Congress

    Sen. Lautenberg, Frank R. [D-NJ

    2010-07-15

    07/15/2010 Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  3. 1998 Toxic Chemical Release Inventory Report for the Emergency Planning and Community Right-to-Know Act of 1986, Title III

    SciTech Connect

    Marjorie B. Stockton

    1999-11-01

    The Emergency Planning and Community Right-to-Know Act (EPCRA) of 1986 [also known as the Superfund Amendment and Reauthorization Act (SARA), Title III], as modified by Executive Order 12856, requires that all federal facilities evaluate the need to submit an annual Toxic Chemical Release Inventory report as prescribed in Title III, Section 313 of this Act. This annual report is due every July for the preceding calendar year. Owners and operators who manufacture, process, or otherwise use certain toxic chemicals above listed threshold quantities are required to report their toxic chemical releases to all environmental mediums (air, water, soil, etc.). At Los Alamos National Laboratory (LANL), no EPCRA Section 313 chemicals were used in 1998 above the reportable threshold limits of 10,000 lb or 25,000 lb. Therefore LANL was not required to submit any Toxic Chemical Release Inventory reports (Form Rs) for 1998. This document was prepared to provide a detailed description of the evaluation on chemical usage and EPCRA Section 313 threshold determinations for LANL for 1998.

  4. Cheminformatics and Computational Chemistry: A Powerful Combination for the Encoding of Process Science

    EPA Science Inventory

    The registration of new chemicals under the Toxicological Substances Control Act (TSCA) and new pesticides under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) requires knowledge of the process science underlying the transformation of organic chemicals in natural...

  5. Cheminformatics Applications and Physicochemical Property Calculators: A Powerful Combination for the Encoding of Process Science

    EPA Science Inventory

    The registration of new chemicals under the Toxic Substances Control Act (TSCA) and new pesticides under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) requires knowledge of the process science underlying the transport and transformation of organic chemicals in n...

  6. Use of QSAR validation principles to enhance predictive approaches in the US EPA ECOSAR model

    EPA Science Inventory

    The US EPA Office of Pollution Prevention and Toxics (OPPT) is responsible for implementing the Toxic Substances Control Act (TSCA). TSCA is the US law that regulates industrial chemicals in the US and OPPT evaluates both new chemicals entering commerce, as well as those chemica...

  7. 1992 Tier Two emergency and hazardous chemical inventory. Emergency Planning and Community Right-To-Know Act, Section 312

    SciTech Connect

    Not Available

    1993-03-01

    This report is a compilation of data on emergency and hazardous chemicals stored at the Hanford Reservation. The report lists name or chemical description, physical and health hazards, inventories and storage location.

  8. Pollution prevention opportunity assessment for the K-25 Site Toxic Substances Control Act Incinerator Operations, Level III

    SciTech Connect

    1995-09-01

    A Level III pollution prevention opportunity assessment (PPOA) was performed for the Oak Ridge K-25 Site Toxic Substances Control Act (TSCA) Incinerator to evaluate pollution prevention (P2) options for various waste streams: The main objective of this study was to identify and evaluate options to reduce the quantities of each waste stream generated by the TSCA Incinerator operations to realize significant environmental and/or economic benefits from P2. For each of the waste streams, P2 options were evaluated following the US Environmental Protection Agency (EPA) hierarchy to (1) reduce the quantity of waste generated, (2) recycle the waste, and/or (3) use alternate waste treatment or segregation methods. This report provides process descriptions, identification and evaluation of P2 options, and final recommendations.

  9. National Emission Standard for Hazardous Air Pollutants compliance verification plan for the K-1435 Toxic Substances Control Act Incinerator

    SciTech Connect

    Ambrose, M.L.

    1986-07-28

    This documentation was prepared for submittal to the Environmental Protection Agency (EPA) in order to meet the requirements of the National Emissions Standards for Hazardous Air Pollutants (NESHAP). This document will emphasize the control of radioactive emissions from the K-1435 Toxic Substances Control Act (TSCA) Incinerator. The TSCA Incinerator is a dual purpose solid/liquid incinerator that is under construction at the Oak Ridge Gaseous Diffusion Plant to destroy radioactively contaminated polychlorinated biphenyls (PCBs) and other hazardous organic wastes in compliance with the TSCA and the Resource Conservation and Recovery Act (RCRA). These wastes are generated at the facilities managed by the Department of Energy, Oak Ridge Operations (DOE-ORO). Destruction of the PCBs and the hazardous organic wastes will be accomplished in a rotary kiln incinerator with an afterburner. The incinerator will thermally destroy the organic constituents of the liquids, solids, and sludges to produce an organically inert ash. In addition to the incinerator, an extensive off-gas treatment facility is being constructed to remove particulate and acidic gas air emissions.

  10. 2009 Toxic Chemical Release Inventory Report for the Emergency Planning and Community Right-to-Know Act of 1986, Title III, Section 313

    SciTech Connect

    Environmental Stewardship Group

    2010-11-01

    For reporting year 2009, Los Alamos National Laboratory (LANL) submitted a Form R report for lead as required under the Emergency Planning and Community Right-to- Know Act (EPCRA) Section 313. No other EPCRA Section 313 chemicals were used in 2009 above the reportable thresholds. This document was prepared to provide a description of the evaluation of EPCRA Section 313 chemical use and threshold determinations for LANL for calendar year 2009, as well as to provide background information about data included on the Form R reports.

  11. 2006 Toxic Chemical Release Inventory Report for the Emergency Planning and Community Right-to-Know Act of 1986, Title III, Section 313

    SciTech Connect

    Ecology and Air Quality Group

    2007-12-12

    For reporting year 2006, Los Alamos National Laboratory (LANL or the Laboratory) submitted Form R reports for lead as required under the Emergency Planning and Community Right-to-Know Act (EPCRA) Section 313. No other EPCRA Section 313 chemicals were used in 2006 above the reportable thresholds. This document was prepared to provide a description of the evaluation of EPCRA Section 313 chemical use and threshold determinations for LANL for calendar year 2006, as well as to provide background information about data included on the Form R reports. Section 313 of EPCRA specifically requires facilities to submit a Toxic Chemical Release Inventory Report (Form R) to the U.S. Environmental Protection Agency (EPA) and state agencies if the owners and operators manufacture, process, or otherwise use any of the listed toxic chemicals above listed threshold quantities. EPA compiles this data in the Toxic Release Inventory database. Form R reports for each chemical over threshold quantities must be submitted on or before July 1 each year and must cover activities that occurred at the facility during the previous year. In 1999, EPA promulgated a final rule on persistent bioaccumulative toxics (PBTs). This rule added several chemicals to the EPCRA Section 313 list of toxic chemicals and established lower reporting thresholds for these and other PBT chemicals that were already reportable. These lower thresholds became applicable in reporting year 2000. In 2001, EPA expanded the PBT rule to include a lower reporting threshold for lead and lead compounds. Facilities that manufacture, process, or otherwise use more than 100 lb of lead or lead compounds must submit a Form R.

  12. 2002 Toxic Chemical Release Inventory Report for the Emergency Planning and Community Right-to-Know Act of 1986, Title III, Section 313

    SciTech Connect

    M. Stockton

    2003-11-01

    For reporting year 2002, Los Alamos National Laboratory (LANL or the Laboratory) submitted Form R reports for lead compounds and mercury as required under the Emergency Planning and Community Right-to-Know Act (EPCRA), Section 313. No other EPCRA Section 313 chemicals were used in 2002 above the reportable thresholds. This document was prepared to provide a description of the evaluation of EPCRA Section 313 chemical usage and threshold determinations for LANL for calendar year 2002 as well as provide background information about the data included on the Form R reports. Section 313 of EPCRA specifically requires facilities to submit a Toxic Chemical Release Inventory report (Form R) to the U.S. Environmental Protection Agency (EPA) and state agencies if the owners and operators manufacture, process, or otherwise use any of the listed toxic chemicals above listed threshold quantities. EPA compiles this data in the Toxic Release Inventory database. Form R reports for each chemical over threshold quantities must be submitted on or before July 1 each year and must cover activities that occurred at the facility during the previous year. In 1999 EPA promulgated a final rule on Persistent Bioaccumulative Toxics (PBTs). This rule added several chemicals to the EPCRA Section 313 list of toxic chemicals and established lower reporting thresholds for these and other PBT chemicals that were already reportable under EPCRA Section 313. These lower thresholds became applicable in reporting year 2000. In 2001, EPA expanded the PBT rule to include a lower reporting threshold for lead and lead compounds. Facilities that manufacture, process, or otherwise use more than 100 lb of lead or lead compounds must submit a Form R.

  13. In silico identification and pharmacological evaluation of novel endocrine disrupting chemicals that act via the ligand-binding domain of the estrogen receptor α.

    PubMed

    McRobb, Fiona M; Kufareva, Irina; Abagyan, Ruben

    2014-09-01

    Endocrine disrupting chemicals (EDCs) pose a significant threat to human health, society, and the environment. Many EDCs elicit their toxic effects through nuclear hormone receptors, like the estrogen receptor α (ERα). In silico models can be used to prioritize chemicals for toxicological evaluation to reduce the amount of costly pharmacological testing and enable early alerts for newly designed compounds. However, many of the current computational models are overly dependent on the chemistry of known modulators and perform poorly for novel chemical scaffolds. Herein we describe the development of computational, three-dimensional multi-conformational pocket-field docking, and chemical-field docking models for the identification of novel EDCs that act via the ligand-binding domain of ERα. These models were highly accurate in the retrospective task of distinguishing known high-affinity ERα modulators from inactive or decoy molecules, with minimal training. To illustrate the utility of the models in prospective in silico compound screening, we screened a database of over 6000 environmental chemicals and evaluated the 24 top-ranked hits in an ERα transcriptional activation assay and a differential scanning fluorimetry-based ERα binding assay. Promisingly, six chemicals displayed ERα agonist activity (32nM-3.98μM) and two chemicals had moderately stabilizing effects on ERα. Two newly identified active compounds were chemically related β-adrenergic receptor (βAR) agonists, dobutamine, and ractopamine (a feed additive that promotes leanness in cattle and poultry), which are the first βAR agonists identified as activators of ERα-mediated gene transcription. This approach can be applied to other receptors implicated in endocrine disruption.

  14. In Silico Identification and Pharmacological Evaluation of Novel Endocrine Disrupting Chemicals That Act via the Ligand-Binding Domain of the Estrogen Receptor α

    PubMed Central

    Kufareva, Irina; Abagyan, Ruben

    2014-01-01

    Endocrine disrupting chemicals (EDCs) pose a significant threat to human health, society, and the environment. Many EDCs elicit their toxic effects through nuclear hormone receptors, like the estrogen receptor α (ERα). In silico models can be used to prioritize chemicals for toxicological evaluation to reduce the amount of costly pharmacological testing and enable early alerts for newly designed compounds. However, many of the current computational models are overly dependent on the chemistry of known modulators and perform poorly for novel chemical scaffolds. Herein we describe the development of computational, three-dimensional multi-conformational pocket-field docking, and chemical-field docking models for the identification of novel EDCs that act via the ligand-binding domain of ERα. These models were highly accurate in the retrospective task of distinguishing known high-affinity ERα modulators from inactive or decoy molecules, with minimal training. To illustrate the utility of the models in prospective in silico compound screening, we screened a database of over 6000 environmental chemicals and evaluated the 24 top-ranked hits in an ERα transcriptional activation assay and a differential scanning fluorimetry-based ERα binding assay. Promisingly, six chemicals displayed ERα agonist activity (32nM–3.98μM) and two chemicals had moderately stabilizing effects on ERα. Two newly identified active compounds were chemically related β-adrenergic receptor (βAR) agonists, dobutamine, and ractopamine (a feed additive that promotes leanness in cattle and poultry), which are the first βAR agonists identified as activators of ERα-mediated gene transcription. This approach can be applied to other receptors implicated in endocrine disruption. PMID:24928891

  15. 2004 Toxic Chemical Release Inventory Report for the Emergency Planning and Community Right-to-Know Act of 1986, Title III, Section 313

    SciTech Connect

    M. Stockton

    2006-01-15

    Section 313 of Emergency Planning and Community Right-to-Know Act (EPCRA) specifically requires facilities to submit a Toxic Chemical Release Inventory Report (Form R) to the U.S. Environmental Protection Agency (EPA) and state agencies if the owners and operators manufacture, process, or otherwise use any of the listed toxic chemicals above listed threshold quantities. EPA compiles this data in the Toxic Release Inventory database. Form R reports for each chemical over threshold quantities must be submitted on or before July 1 each year and must cover activities that occurred at the facility during the previous year. For reporting year 2004, Los Alamos National Laboratory (LANL or the Laboratory) submitted Form R reports for lead compounds, nitric acid, and nitrate compounds as required under the EPCRA Section 313. No other EPCRA Section 313 chemicals were used in 2004 above the reportable thresholds. This document provides a description of the evaluation of EPCRA Section 313 chemical use and threshold determinations for LANL for calendar year 2004, as well as background information about data included on the Form R reports.

  16. Common synonyms: For chemicals listed under Section 313 of the Emergency Planning and Community Right-To-Know act

    SciTech Connect

    Not Available

    1992-06-01

    This glossary contains chemical names and their synonyms for substances covered by the reporting requirements of SARA Title III, section 313. The glossary was developed to aid in determining whether a facility manufactures, processes, or otherwise uses a chemical subject to section 313 reporting. These synonyms are available to the EPA through the public literature, primarily CAS Online. The glossary is divided into two parts. Part 1 is a listing by CAS registry number. Part 2 contains names and synonyms in an alphabetical listing.

  17. Common synonyms for chemicals listed under section 313 of the Emergency Planning and Community Right-To-Know Act

    SciTech Connect

    Not Available

    1991-01-01

    The glossary contains chemical names and their synonyms for substances covered by the reporting requirements of SARA Title III, section 313. The glossary was developed to aid in determining whether a facility manufactures, processes, or otherwise uses a chemical subject to section 313 reporting. These synonyms are available to the EPA through the public literature, primarily CAS Online. The glossary is divided into two parts. Part 1 is a listing by CAS registry number. Part 2 contains names and synonyms in an alphabetical listing.

  18. Molecular modeling for screening environmental chemicals for estrogenicity: use of the toxicant-target approach.

    PubMed

    Rabinowitz, James R; Little, Stephen B; Laws, Susan C; Goldsmith, Michael-Rock

    2009-09-01

    There is a paucity of relevant experimental information available for the evaluation of the potential health and environmental effects of many man made chemicals. Knowledge of the potential pathways for activity provides a rational basis for the extrapolations inherent in the preliminary evaluation of risk and the establishment of priorities for obtaining missing data for environmental chemicals. The differential step in many mechanisms of toxicity may be generalized as the interaction between a small molecule (a potential toxicant) and one or more macromolecular targets. An approach based on computation of the interaction between a potential molecular toxicant and a library of macromolecular targets of toxicity has been proposed for preliminary chemical screening. In the current study, the interaction between a series of environmentally relevant chemicals and models of the rat estrogen receptors (ER) was computed and the results compared to an experimental data set of their relative binding affinities. The experimental data set consists of 281 chemicals, selected from the U.S. EPA's Toxic Substances Control Act (TSCA) inventory, that were initially screened using the rat uterine cytosolic ER-competitive binding assay. Secondary analysis, using Lineweaver-Burk plots and slope replots, was applied to confirm that only 15 of these test chemicals were true competitive inhibitors of ER binding with experimental inhibition constants (K(i)) less than 100 microM. Two different rapid computational docking methods have been applied. Each provides a score that is a surrogate for the strength of the interaction between each ligand-receptor pair. Using the score that indicates the strongest interaction for each pair, without consideration of the geometry of binding between the toxicant and the target, all of the active molecules were discovered in the first 16% of the chemicals. When a filter is applied on the basis of the geometry of a simplified pharmacophore for binding to

  19. Molecular modeling for screening environmental chemicals for estrogenicity: use of the toxicant-target approach.

    PubMed

    Rabinowitz, James R; Little, Stephen B; Laws, Susan C; Goldsmith, Michael-Rock

    2009-09-01

    There is a paucity of relevant experimental information available for the evaluation of the potential health and environmental effects of many man made chemicals. Knowledge of the potential pathways for activity provides a rational basis for the extrapolations inherent in the preliminary evaluation of risk and the establishment of priorities for obtaining missing data for environmental chemicals. The differential step in many mechanisms of toxicity may be generalized as the interaction between a small molecule (a potential toxicant) and one or more macromolecular targets. An approach based on computation of the interaction between a potential molecular toxicant and a library of macromolecular targets of toxicity has been proposed for preliminary chemical screening. In the current study, the interaction between a series of environmentally relevant chemicals and models of the rat estrogen receptors (ER) was computed and the results compared to an experimental data set of their relative binding affinities. The experimental data set consists of 281 chemicals, selected from the U.S. EPA's Toxic Substances Control Act (TSCA) inventory, that were initially screened using the rat uterine cytosolic ER-competitive binding assay. Secondary analysis, using Lineweaver-Burk plots and slope replots, was applied to confirm that only 15 of these test chemicals were true competitive inhibitors of ER binding with experimental inhibition constants (K(i)) less than 100 microM. Two different rapid computational docking methods have been applied. Each provides a score that is a surrogate for the strength of the interaction between each ligand-receptor pair. Using the score that indicates the strongest interaction for each pair, without consideration of the geometry of binding between the toxicant and the target, all of the active molecules were discovered in the first 16% of the chemicals. When a filter is applied on the basis of the geometry of a simplified pharmacophore for binding to

  20. Environmental implementation plan: Chapter 5, Chemical management, pollution prevention and other compliance programs. Draft revision

    SciTech Connect

    Peterson, G.L.

    1993-11-18

    Compliance with environmental regulations and US Department of Energy Orders (DOE) relating to environmental protection is an important part of SRS`s program. Over the past few years, the number of environmental regulations has increased. The strategy to comply with new and existing environmental regulations and DOE orders is described in chapter two. In this chapter, the following environmental programs are described: Toxic Substances Control Act (TSCA); Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA); Emergency Planning and Community Right-to-Know Act (EPCRA); and SPCC/BMP/Pollution Prevention Plans;The implementation section identifies issues and those responsible to achieve defined objectives.

  1. Hanford 1999 Tier 2 Emergency and Hazardous Chemical Inventory Emergency Planning and Community Right to Know Act Section 312

    SciTech Connect

    ZALOUDEK, D.E.

    2000-03-01

    The Hanford Site covers approximately 1,450 square kilometers (560 square miles) of land that is owned by the U.S. Government and managed by the U.S. Department of Energy, Richland Operations Office (DOE-RL). The Hanford Site is located northwest of the city of Richland, Washington. The city of Richland adjoins the southeastern portion of the Hanford Site boundary and is the nearest population center. Activities on the Hanford Site are centralized in numerically designated areas. The 100 Areas, located along the Columbia River, contain deactivated reactors. The processing units are in the 200 Areas, which are on a plateau approximately 11 kilometers (7 miles) from the Columbia River. The 300 Area, located adjacent to and north of Richland, contains research and development laboratories. The 400 Area, 8 kilometers (5 miles) northwest of the 300 Area, contains the Fast Flux Test Facility previously used for testing liquid metal reactor systems. Adjacent to the north of Richland, the 1100 Area contains offices associated with administration, maintenance, transportation, and materials procurement and distribution. The 600 Area covers all locations not specifically given an area designation. This Tier Two Emergency and Hazardous Chemical Inventory report contains information pertaining to hazardous chemicals managed by DOE-RL and its contractors on the Hanford Site. It does not include chemicals maintained in support of activities conducted by others on lands covered by leases, use permits, easements, and other agreements whereby land is used by parties other than DOE-RL. For example, this report does not include chemicals stored on state owned or leased lands (including the burial ground operated by US Ecology, Inc.), lands owned or used by the Bonneville Power Administration (including the Midway Substation and the Ashe Substation), lands used by the National Science Foundation (the Laser Interferometer Gravitational-Wave Observatory), lands leased to the Washington

  2. 1998 Tier two emergency and hazardous chemical inventory - emergency planning and community right-to-know act section 312

    SciTech Connect

    ZALOUDEK, D.E.

    1999-03-02

    The Hanford Site covers approximately 1,450 square kilometers (560 square miles) of land that is owned by the U.S, Government and managed by the U.S. Department of Energy, Richland Operations Office (DOE-RL). The Hanford Site is located northwest of the city of Richland, Washington. The city of Richland adjoins the southeastern portion of the Hanford Site boundary and is the nearest population center. Activities on the Hanford Site are centralized in numerically designated areas. The 100 Areas, located along the Columbia River, contain deactivated reactors. The processing units are in the 200 Areas, which are on a plateau approximately 11 kilometers (7 miles) from the Columbia River. The 300 Area, located adjacent to and north of Richland, contains research and development laboratories. The 400 Area, 8 kilometers (5 miles) northwest of the 300 Area, contains the Fast Flux Test Facility previously used for testing liquid metal reactor systems. Adjacent to the north of Richland, the 1100 Area contains offices associated with administration, maintenance, transportation, and materials procurement and distribution. The 600 Area covers all locations not specifically given an area designation. This Tier Two Emergency and Hazardous Chemical Inventory report contains information pertaining to hazardous chemicals managed by DOE-RL and its contractors on the Hanford Site. It does not include chemicals maintained in support of activities conducted by others on lands covered by leases, use permits, easements, and other agreements whereby land is used by parties other than DOE-RL. For example, this report does not include chemicals stored on state owned or leased lands (including the burial ground operated by US Ecology, Inc.), lands owned or used by the Bonneville Power Administration (including the Midway Substation and the Ashe Substation), lands used by the National Science Foundation (the Laser Interferometer Gravitational-Wave Observatory), lands leased to the Washington

  3. 40 CFR 799.6755 - TSCA partition coefficient (n-octanol/water), shake flask method.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...-octanol from organic contaminants with similar vapor pressure if they are present. (ii) Water. Distilled...) Neely, W.B. et al. Partition Coefficients to Measure Bioconcentration Potential of Organic Chemicals in.... and R.T. Morris, A Rapid Method for Estimating Log P for Organic Chemicals, EPA-600/3-78-049...

  4. 40 CFR 799.6755 - TSCA partition coefficient (n-octanol/water), shake flask method.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...-octanol from organic contaminants with similar vapor pressure if they are present. (ii) Water. Distilled...) Neely, W.B. et al. Partition Coefficients to Measure Bioconcentration Potential of Organic Chemicals in.... and R.T. Morris, A Rapid Method for Estimating Log P for Organic Chemicals, EPA-600/3-78-049...

  5. 40 CFR 799.6755 - TSCA partition coefficient (n-octanol/water), shake flask method.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-octanol from organic contaminants with similar vapor pressure if they are present. (ii) Water. Distilled... Potential of Organic Chemicals in Fish. Environmental Science and Technology 8:1113 (1974). (2) Leo, A. et... Chromatography 157:386 (1978). (4) Veith G.D. and R.T. Morris, A Rapid Method for Estimating Log P for...

  6. 40 CFR 799.6755 - TSCA partition coefficient (n-octanol/water), shake flask method.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...-octanol from organic contaminants with similar vapor pressure if they are present. (ii) Water. Distilled... Potential of Organic Chemicals in Fish. Environmental Science and Technology 8:1113 (1974). (2) Leo, A. et... Chromatography 157:386 (1978). (4) Veith G.D. and R.T. Morris, A Rapid Method for Estimating Log P for...

  7. 40 CFR 799.6756 - TSCA partition coefficient (n-octanol/water), generator column method.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... could be measured. (ii) In the study of the environmental fate of organic chemicals, the Kow has become... partition out of the water and into the organic portion of soils/sediments and into lipophilic tissue. The... organic compounds. The development of this test method is described in the references listed in...

  8. 40 CFR 799.6756 - TSCA partition coefficient (n-octanol/water), generator column method.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... could be measured. (ii) In the study of the environmental fate of organic chemicals, the Kow has become... partition out of the water and into the organic portion of soils/sediments and into lipophilic tissue. The... organic compounds. The development of this test method is described in the references listed in...

  9. 40 CFR 799.6756 - TSCA partition coefficient (n-octanol/water), generator column method.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... could be measured. (ii) In the study of the environmental fate of organic chemicals, the Kow has become... partition out of the water and into the organic portion of soils/sediments and into lipophilic tissue. The... organic compounds. The development of this test method is described in the references listed in...

  10. 40 CFR 799.6756 - TSCA partition coefficient (n-octanol/water), generator column method.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... could be measured. (ii) In the study of the environmental fate of organic chemicals, the Kow has become... partition out of the water and into the organic portion of soils/sediments and into lipophilic tissue. The... organic compounds. The development of this test method is described in the references listed in...

  11. 40 CFR 799.6755 - TSCA partition coefficient (n-octanol/water), shake flask method.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...-octanol from organic contaminants with similar vapor pressure if they are present. (ii) Water. Distilled... Potential of Organic Chemicals in Fish. Environmental Science and Technology 8:1113 (1974). (2) Leo, A. et... Chromatography 157:386 (1978). (4) Veith G.D. and R.T. Morris, A Rapid Method for Estimating Log P for...

  12. Progress report and technology status development of an EG and G Berthold LB-150 alpha/beta particulate monitor for use on the East Tennessee Technology Park Toxic Substances Control Act Incinerator

    SciTech Connect

    Shor, J.T.; Singh, S.P.N.; Gibson, L.V. Jr.

    1998-06-01

    The purpose of this project was to modify and evaluate a commercially available EG and G Berthold LB-150 alpha-beta radionuclide particulate monitor for the high-temperature and moisture-saturation conditions of the East Tennessee Technology Park (formerly K-25 Site) Toxic Substances Control Act (TSCA) Incinerator stack. The monitor was originally outfitted for operation at gas temperatures of 150 F on the defunct Los Alamos National Laboratory (LANL) controlled air incinerator, and the objective was to widen its operating envelope. A laboratory apparatus was constructed that simulated the effects of water-saturated air at the TSCA Incinerator stack-gas temperatures, 183 F. An instrumented set of heat exchangers was constructed to then condition the gas so that the radionuclide monitor could be operated without condensation. Data were collected under the conditions of the elevated temperatures and humidities and are reported herein, and design considerations of the apparatus are provided. The heat exchangers and humidification equipment performed as designed, the Mylar film held, and the instrument suffered no ill effects. However, for reasons as yet undetermined, the sensitivity of the radionuclide detection diminishes as the gas temperature is elevated, whether the gas is humidified or not. The manufacturer has had no experience with (a) the operation of the monitor under these conditions and (b) any commercial market that might exist for an instrument that operates under these conditions. The monitor was not installed into the radiologically contaminated environment of the TSCA Incinerator stack pending resolution of this technical issue.

  13. Consolidated List of chemicals Subject to Reporting Under the Emergency Planning and Community Right to Know Act: SARA Section 302 Extremely Hazardous Substances, CERCLA Hazardous Substances and SARA Section 313 Toxic Chemicals (Title III, list of lists), EZ-Base (trade name) version (for microcomputers). Data file

    SciTech Connect

    Not Available

    1992-05-01

    This is the diskette based version of the Office of Toxic Substances Consolidated List of Chemicals Subject to Reporting Under Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA) and SARA Section 302 Extremely Hazardous Substances, as well as CERCLA Hazardous Substances. Title III is also known as the Emergency Planning and Community Right to Know Act. The diskette is designed to generate either a printout or a dBase III file from any IBM or IBM compatible system.

  14. Consolidated list of chemical subject to reporting under the Emergency Planning and Community Right-to-Know Act: SARA Section 302 extremely hazardous substances, CERCLA hazardous substances and SARA Section 313 toxic chemicals (Title III, list of lists) (for microcomputers). Data file

    SciTech Connect

    Not Available

    1991-01-01

    This is the disk based version of the Office of Toxic Substances Consolidated list of chemicals subject to reporting under Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA) and SARA Section 302 Extremely Hazardous Substances, as well as CERCLA Hazardous Substances. Title III is also known as the Emergency Planning and Community Right to Know Act. The disks are designed to generate either a printout or a dBase III file from any IBM or IBM compatible system.

  15. 75 FR 80665 - Sixty-Seventh Report of the TSCA Interagency Testing Committee to the Administrator of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-22

    ... chemicals with insufficient dermal absorption rate data, and 207 High Production Volume (HPV) Challenge... (HPV) Recommended. Challenge Program orphan chemicals. 56 August 2005 4 HPV Challenge Program...

  16. 40 CFR 710.1 - Scope and compliance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ACT TSCA CHEMICAL INVENTORY REGULATIONS General Provisions § 710.1 Scope and compliance. (a) This part... process chemical substances for commercial purposes under section 8(a) of the Toxic Substances Control Act... information necessary for administration of the Act and requires EPA to issue regulations for the purpose...

  17. Uranium effluent testing for the Oak Ridge Toxic Substances Control Act mixed waste incinerator

    SciTech Connect

    Shor, J.T.; Bostick, W.D.; Hoffmann, D.P.; Gibson, L.V. Jr.; Ho, T.C.

    1993-07-01

    The Oak Ridge K-25 Site Toxic Substances Control Act (TSCA) Incinerator has been undergoing a series of routine tests to determine uranium partitioning to the stack, scrubber waters, and bottom ash. This paper discusses the results of the most recent experiment in which relatively high rates of uranium stack gas emissions were identified: 6.11 g/h or 8 wt % based on the uranium feed. These data are compared with earlier data, and an empirical correlation is suggested between the stack emissions of uranium and the product of the uranium and chlorine concentration of the feed. This is consistent with certain findings with other metals, in which increasing chlorine feed contents led to increasing emissions.

  18. First-in-Humans Study of the Safety, Tolerability, and Pharmacokinetics of ACT-451840, a New Chemical Entity with Antimalarial Activity

    PubMed Central

    Bruderer, Shirin; Hurst, Noémie; de Kanter, Ruben; Miraval, Tommaso; Pfeifer, Thomas; Donazzolo, Yves

    2014-01-01

    Emerging resistance to antimalarial agents raises the need for new drugs. ACT-451840 is a new compound with potent activity against sensitive and resistant Plasmodium falciparum strains. This was a first-in-humans single-ascending-dose study to investigate the safety, tolerability, and pharmacokinetics of ACT-451840 across doses of 10, 50, 200, and 500 mg in healthy male subjects. In the 200- and 500-mg dose groups, the effect of food was investigated, and antimalarial activity was assessed using an ex vivo bioassay with P. falciparum. No (serious) adverse events leading to discontinuation were reported. At the highest dose level, the peak drug concentration (Cmax) and the area under the plasma concentration-time curve from zero to infinity of ACT-451840 under fasted conditions reached 11.9 ng/ml and 100.6 ng · h/ml, respectively, and these were approximately 13-fold higher under fed conditions. Food did not affect the half-life (approximately 34 h) of the drug, while the Cmax was attained 2.0 and 3.5 h postdose under fasted and fed conditions, respectively. The plasma concentrations estimated by the bioassay were approximately 4-fold higher than those measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Several potentially active metabolites were also identified. ACT-451840 was well tolerated across all doses. Exposure to ACT-451840 significantly increased with food. The bioassay indicated the presence of circulating active metabolites. (This study has been registered at ClinicalTrials.gov under registration no. NCT02186002.) PMID:25421475

  19. First-in-humans study of the safety, tolerability, and pharmacokinetics of ACT-451840, a new chemical entity with antimalarial activity.

    PubMed

    Bruderer, Shirin; Hurst, Noémie; de Kanter, Ruben; Miraval, Tommaso; Pfeifer, Thomas; Donazzolo, Yves; Dingemanse, Jasper

    2015-02-01

    Emerging resistance to antimalarial agents raises the need for new drugs. ACT-451840 is a new compound with potent activity against sensitive and resistant Plasmodium falciparum strains. This was a first-in-humans single-ascending-dose study to investigate the safety, tolerability, and pharmacokinetics of ACT-451840 across doses of 10, 50, 200, and 500 mg in healthy male subjects. In the 200- and 500-mg dose groups, the effect of food was investigated, and antimalarial activity was assessed using an ex vivo bioassay with P. falciparum. No (serious) adverse events leading to discontinuation were reported. At the highest dose level, the peak drug concentration (Cmax) and the area under the plasma concentration-time curve from zero to infinity of ACT-451840 under fasted conditions reached 11.9 ng/ml and 100.6 ng·h/ml, respectively, and these were approximately 13-fold higher under fed conditions. Food did not affect the half-life (approximately 34 h) of the drug, while the Cmax was attained 2.0 and 3.5 h postdose under fasted and fed conditions, respectively. The plasma concentrations estimated by the bioassay were approximately 4-fold higher than those measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Several potentially active metabolites were also identified. ACT-451840 was well tolerated across all doses. Exposure to ACT-451840 significantly increased with food. The bioassay indicated the presence of circulating active metabolites. (This study has been registered at ClinicalTrials.gov under registration no. NCT02186002.). PMID:25421475

  20. The Clean Water Act

    SciTech Connect

    Piatt, J.

    1995-12-31

    The Federal Water Pollution Control Act, commonly called the Clean Water Act (CWA), was adopted on 18 October 1972. Since then it has been amended 18 times, the last amendments were adopted on 4 February 1987. As established, its objective is: to restore and maintain the chemical, physical, and biological integrity of the Nation`s waters. And has, as an interim goal: water quality which provides for the protection and propagation of fish, shellfish, and wildlife and provides for recreation in and on the water. It should be noted that Congress established as the Act`s ultimate goal: the discharge of pollutants into the navigable waters be eliminated. The Act set out to meet this lofty objective and goal through the development and implementation of controls on the point source discharges and the nonpoint source release of pollutants. The regulation of point and nonpoint sources as well as future requirements are discussed.

  1. ACT: Acting Out Central Theme.

    ERIC Educational Resources Information Center

    Kise, Joan Duff

    1982-01-01

    The author describes ACT (Acting Out Central Theme), a method for dealing with psychomotor, cognitive, and affective domains in slow readers. The ACT approach involves three sessions which focus on discussion of a theme such as friendship, presentaton of the theme as a skit, and assignment of topics to individual students. (SW)

  2. [List of hazardous and extremely hazardous chemicals at the Oak Ridge Y-12 Plant]. Emergency Planning and Community Right-to-Know Act Section 311

    SciTech Connect

    Evans, R.A.; Martin, K.J.

    1997-03-01

    The information reflects changes in the lists of hazardous chemicals present at this facility in amounts equal to or greater than 10,000 pounds and extremely hazardous chemicals present in amounts equal to or greater than 500 pounds or its Threshold Planning Quantity, whichever was less. These lists represent the following: (1) List of materials last reported in March 1996 (reference Y/TS-l482); (2) Materials to be deleted from list; (3) Materials to be added to list; and (4) Revised list of materials.

  3. Juggling Act

    ERIC Educational Resources Information Center

    Rudalevige, Andrew

    2009-01-01

    Two education bills from George W. Bush's first term are long overdue for reauthorization. One, of course, is the No Child Left Behind Act (NCLB), passed in late 2001. The other is the Education Sciences Reform Act (ESRA), which in November 2002 replaced the Office of Educational Research and Improvement (OERI) with a new Institute of Education…

  4. ACT Test

    MedlinePlus

    ... this page helpful? Also known as: ACT; Activated Coagulation Time Formal name: Activated Clotting Time Related tests: ... in the blood called platelets and proteins called coagulation factors are activated in a sequence of steps ...

  5. Acting Atoms.

    ERIC Educational Resources Information Center

    Farin, Susan Archie

    1997-01-01

    Describes a fun game in which students act as electrons, protons, and neutrons. This activity is designed to help students develop a concrete understanding of the abstract concept of atomic structure. (DKM)

  6. 75 FR 16670 - 1-Propene, 2,3,3,3-tetrafluoro-; Withdrawal of Significant New Use Rule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ... Control Act (TSCA) for the chemical substance identified as 1-Propene, 2,3,3,3- tetrafluoro- (CAS No. 754..., Chemical Control Division (7405M), Office of Pollution Prevention and Toxics, Environmental Protection... 27, 1989 (54 FR 31314). The record for the direct final ] SNUR for the chemical substance...

  7. Can Small Chemical Modifications of Natural Pan-inhibitors Modulate the Biological Selectivity? The Case of Curcumin Prenylated Derivatives Acting as HDAC or mPGES-1 Inhibitors.

    PubMed

    Iranshahi, Mehrdad; Chini, Maria Giovanna; Masullo, Milena; Sahebkar, Amirhossein; Javidnia, Azita; Chitsazian Yazdi, Mahsa; Pergola, Carlo; Koeberle, Andreas; Werz, Oliver; Pizza, Cosimo; Terracciano, Stefania; Piacente, Sonia; Bifulco, Giuseppe

    2015-12-24

    Curcumin, or diferuloylmethane, a polyphenolic molecule isolated from the rhizome of Curcuma longa, is reported to modulate multiple molecular targets involved in cancer and inflammatory processes. On the basis of its pan-inhibitory characteristics, here we show that simple chemical modifications of the curcumin scaffold can regulate its biological selectivity. In particular, the curcumin scaffold was modified with three types of substituents at positions C-1, C-8, and/or C-8' [C5 (isopentenyl, 5-8), C10 (geranyl, 9-12), and C15 (farnesyl, 13, 14)] in order to make these molecules more selective than the parent compound toward two specific targets: histone deacetylase (HDAC) and microsomal prostaglandin E2 synthase-1 (mPGES-1). From combined in silico and in vitro analyses, three selective inhibitors by proper substitution at position 8 were revealed. Compound 13 has improved HDAC inhibitory activity and selectivity with respect to the parent compound, while 5 and 9 block the mPGES-1 enzyme. We hypothesize about the covalent interaction of curcumin, 5, and 9 with the mPGES-1 binding site. PMID:26588603

  8. Can Small Chemical Modifications of Natural Pan-inhibitors Modulate the Biological Selectivity? The Case of Curcumin Prenylated Derivatives Acting as HDAC or mPGES-1 Inhibitors.

    PubMed

    Iranshahi, Mehrdad; Chini, Maria Giovanna; Masullo, Milena; Sahebkar, Amirhossein; Javidnia, Azita; Chitsazian Yazdi, Mahsa; Pergola, Carlo; Koeberle, Andreas; Werz, Oliver; Pizza, Cosimo; Terracciano, Stefania; Piacente, Sonia; Bifulco, Giuseppe

    2015-12-24

    Curcumin, or diferuloylmethane, a polyphenolic molecule isolated from the rhizome of Curcuma longa, is reported to modulate multiple molecular targets involved in cancer and inflammatory processes. On the basis of its pan-inhibitory characteristics, here we show that simple chemical modifications of the curcumin scaffold can regulate its biological selectivity. In particular, the curcumin scaffold was modified with three types of substituents at positions C-1, C-8, and/or C-8' [C5 (isopentenyl, 5-8), C10 (geranyl, 9-12), and C15 (farnesyl, 13, 14)] in order to make these molecules more selective than the parent compound toward two specific targets: histone deacetylase (HDAC) and microsomal prostaglandin E2 synthase-1 (mPGES-1). From combined in silico and in vitro analyses, three selective inhibitors by proper substitution at position 8 were revealed. Compound 13 has improved HDAC inhibitory activity and selectivity with respect to the parent compound, while 5 and 9 block the mPGES-1 enzyme. We hypothesize about the covalent interaction of curcumin, 5, and 9 with the mPGES-1 binding site.

  9. Field Evaluation of MERCEM Mercury Emission Analyzer System at the Oak Ridge TSCA Incinerator East Tennessee Technology Park Oak Ridge, Tennessee

    SciTech Connect

    2000-03-01

    The authors reached the following conclusions: (1) The two-month evaluation of the MERCEM total mercury monitor from Perkin Elmer provided a useful venue in determining the feasibility of using a CEM to measure total mercury in a saturated flue gas. (2) The MERCEM exhibited potential at a mixed waste incinerator to meet requirements proposed in PS12 under conditions of operation with liquid feeds only at stack mercury concentrations in the range of proposed MACT standards. (3) Performance of the MERCEM under conditions of incinerating solid and liquid wastes simultaneously was less reliable than while feeding liquid feeds only for the operating conditions and configuration of the host facility. (4) The permeation tube calibration method used in this test relied on the CEM internal volumetric and time constants to relate back to a concentration, whereas a compressed gas cylinder concentration is totally independent of the analyzer mass flowmeter and flowrates. (5) Mercury concentration in the compressed gas cylinders was fairly stable over a 5-month period. (6) The reliability of available reference materials was not fully demonstrated without further evaluation of their incorporation into routine operating procedures performed by facility personnel. (7) The degree of mercury control occurring in the TSCA Incinerator off-gas cleaning system could not be quantified from the data collected in this study. (8) It was possible to conduct the demonstration at a facility incinerating radioactively contaminated wastes and to release the equipment for later unrestricted use elsewhere. (9) Experience gained by this testing answered additional site-specific and general questions regarding the operation and maintenance of CEMs and their use in compliance monitoring of total mercury emissions from hazardous waste incinerators.

  10. 77 FR 28281 - Withdrawal of Revocation of TSCA Section 4 Testing Requirements for One High Production Volume...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-14

    ... issue of March 16, 2012 (77 FR 15609) (FRL-9335-6). If you have questions regarding the applicability of... INFORMATION CONTACT: For technical information contact: Catherine Roman, Chemical Control Division (7405M...., Washington, DC 20460-0001; telephone number: (202) 564-8157; email address: roman.catherine@epa.gov ....

  11. Representation of chemical information in OASIS centralized 3D database for existing chemicals.

    PubMed

    Nikolov, Nikolai; Grancharov, Vanio; Stoyanova, Galya; Pavlov, Todor; Mekenyan, Ovanes

    2006-01-01

    The present inventory of existing chemicals in regulatory agencies in North America and Europe, encompassing the chemicals of the European Chemicals Bureau (EINECS, with 61 573 discrete chemicals); the Danish EPA (159 448 chemicals); the U.S. EPA (TSCA, 56 882 chemicals; HPVC, 10 546 chemicals) and pesticides' active and inactive ingredients of the U.S. EPA (1379 chemicals); the Organization for Economic Cooperation and Development (HPVC, 4750 chemicals); Environment Canada (DSL, 10851 chemicals); and the Japanese Ministry of Economy, Trade, and Industry (16811), was combined in a centralized 3D database for existing chemicals. The total number of unique chemicals from all of these databases exceeded 185 500. Defined and undefined chemical mixtures and polymers are handled, along with discrete (hydrolyzing and nonhydrolyzing) chemicals. The database manager provides the storage and retrieval of chemical structures with 2D and 3D data, accounting for molecular flexibility by using representative sets of conformers for each chemical. The electronic and geometric structures of all conformers are quantum-chemically optimized and evaluated. Hence, the database contains over 3.7 million 3D records with hundreds of millions of descriptor data items at the levels of structures, conformers, or atoms. The platform contains a highly developed search subsystem--a search is possible on Chemical Abstracts Service numbers; names; 2D and 3D fragment searches; structural, conformational, or atomic properties; affiliation in other chemical databases; structure similarity; logical combinations; saved queries; and search result exports. Models (collections of logically related descriptors) are supported, including information on a model's author, date, bioassay, organs/tissues, conditions, administration, and so forth. Fragments can be interactively constructed using a visual structure editor. A configurable database browser is designed for the inspection and editing of all types of

  12. Representation of chemical information in OASIS centralized 3D database for existing chemicals.

    PubMed

    Nikolov, Nikolai; Grancharov, Vanio; Stoyanova, Galya; Pavlov, Todor; Mekenyan, Ovanes

    2006-01-01

    The present inventory of existing chemicals in regulatory agencies in North America and Europe, encompassing the chemicals of the European Chemicals Bureau (EINECS, with 61 573 discrete chemicals); the Danish EPA (159 448 chemicals); the U.S. EPA (TSCA, 56 882 chemicals; HPVC, 10 546 chemicals) and pesticides' active and inactive ingredients of the U.S. EPA (1379 chemicals); the Organization for Economic Cooperation and Development (HPVC, 4750 chemicals); Environment Canada (DSL, 10851 chemicals); and the Japanese Ministry of Economy, Trade, and Industry (16811), was combined in a centralized 3D database for existing chemicals. The total number of unique chemicals from all of these databases exceeded 185 500. Defined and undefined chemical mixtures and polymers are handled, along with discrete (hydrolyzing and nonhydrolyzing) chemicals. The database manager provides the storage and retrieval of chemical structures with 2D and 3D data, accounting for molecular flexibility by using representative sets of conformers for each chemical. The electronic and geometric structures of all conformers are quantum-chemically optimized and evaluated. Hence, the database contains over 3.7 million 3D records with hundreds of millions of descriptor data items at the levels of structures, conformers, or atoms. The platform contains a highly developed search subsystem--a search is possible on Chemical Abstracts Service numbers; names; 2D and 3D fragment searches; structural, conformational, or atomic properties; affiliation in other chemical databases; structure similarity; logical combinations; saved queries; and search result exports. Models (collections of logically related descriptors) are supported, including information on a model's author, date, bioassay, organs/tissues, conditions, administration, and so forth. Fragments can be interactively constructed using a visual structure editor. A configurable database browser is designed for the inspection and editing of all types of

  13. 40 CFR 710.38 - Confidentiality.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Confidentiality. 710.38 Section 710.38 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA... may assert a claim of confidentiality for the chemical identity of a specific chemical substance...

  14. 77 FR 19861 - Certain Polybrominated Diphenylethers; Significant New Use Rule and Test Rule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-02

    ...The Agency is proposing to amend the Toxic Substances Control Act (TSCA) section 5(a) Significant New Use Rule (SNUR), for certain polybrominated diphenylethers (PBDEs) by: Designating processing of six PBDEs, or any combination of these chemical substances resulting from a chemical reaction, as a significant new use; designating manufacturing, importing, and processing of a seventh PBDE,......

  15. 76 FR 49471 - Agency Information Collection Activities; Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-10

    ... FURTHER INFORMATION CONTACT: For technical information contact: Mike Mattheisen, Chemical Control Division.... Abstract: Section 4 of the Toxic Substances Control Act (TSCA) is designed to assure that chemicals that... Voluntary Data Submission'' and identified by EPA ICR No. 1139.09 and OMB Control No. 2070-0033,...

  16. 76 FR 55622 - Glymes; Proposed Significant New Use; Extension of Comment Period

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-08

    ... Breedlove, Chemical Control Division (7405M), Office of Pollution Prevention and Toxics, Environmental...: September 1, 2011. Maria J. Doa, Director, Chemical Control Division, Office of Pollution Prevention and... significant new use rule (SNUR) under section 5(a)(2) of the Toxic Substances Control Act (TSCA) for 14...

  17. Chemical Facility Security Improvement Act of 2013

    THOMAS, 113th Congress

    Rep. Jackson Lee, Sheila [D-TX-18

    2013-01-03

    02/12/2013 Referred to the Subcommittee on Cybersecurity, Infrastructure Protection, and Security Technologies. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  18. Intergovernmental consultation and coordination and emergency response: The relationship between ICCB (Intergovernmental Consultation and Coordination Board) and SARA (Superfund Amendments and Reauthorization Act of 1986) Title III in the US Army's Chemical Stockpile Disposal Program

    SciTech Connect

    Feldman, D.L.

    1989-02-01

    The relationship between Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA) and the Intergovernmental Consultation and Coordination Board (ICCB) in the US Army's Chemical Stockpile Disposal Program (CSDP) is examined from four perspectives: (1) the current status and likely future direction of SARA implementation in the eight CSDP continental United States sites; (2) the applicability of SARA to the CSDP; (3) the effect of SARA information management upon the ICCB; and (4) challenges posed by SARA in the areas of public participation and intergovernmental relations which make the interface between emergency planning and intergovernmental relations in the CSDP more complex than originally envisioned in the program's Final Programmatic Environmental Impact Statement. The emergency planning structures developed by SARA have important parallels with the CSDP's ICCB. It is important to maintain a separation between these emergency planning structures and ICCBs, which will handle additional concerns other than emergency planning. While considerable variation exists in patterns of SARA Title III implementation in CSDP states, shared characteristics include: (1) Local Emergency Planning Committees (LEPCs) faced with problems of staffing, resources, and membership attrition; (2) unclear lines of planning authority in some LEPCs; and (3) the legitimization of unconventional participation in emergency planning. 34 refs., 1 tab.

  19. 77 FR 20354 - Meetings; Sunshine Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-04

    ... From the Federal Register Online via the Government Publishing Office CHEMICAL SAFETY AND HAZARD INVESTIGATION BOARD Meetings; Sunshine Act The U.S. Chemical Safety and Hazard Investigation Board (CSB... Nemours and Co. Inc. chemical plant in Buffalo, New York. The incident involved a contract welder...

  20. 76 FR 69238 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-08

    ...; ] CHEMICAL SAFETY AND HAZARD INVESTIGATION BOARD Sunshine Act Meeting In connection with its investigation into three iron dust flash fires at the Hoeganaes facility in Gallatin, TN., the U.S. Chemical Safety... prior to the public meeting. For more information, please contact the Chemical Safety and...

  1. Act resilient.

    PubMed

    Joseph, Genie; Bice-Stephens, Wynona

    2014-01-01

    Attendees have reported changing from being fearful to serene, from listless to energized, from disengaged to connected, and becoming markedly less anxious in a few weeks. Anecdotally, self-reported stress levels have been reduced by over 50% after just one class. Attendees learn not to be afraid of their feelings by working with emotions in a playful manner. When a person can act angry, but separate himself from his personal story, the emotional energy exists in a separate form that is not attached to specific events, and can be more easily dealt with and neutralized. Attendees are taught to "take out the emotional trash" through expressive comedy. They become less intimated by their own emotional intensity and triggers as they learn how even metaphorical buckets of anger, shame, guilt and hurt can be emotionally emptied. The added benefit is that this is accomplished without the disclosure of personal information of the requirement to reexperience past pain which can trigger its own cascade of stress. PMID:24706248

  2. 40 CFR 710.59 - Availability of reporting form and instructions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS Inventory Update Reporting for 2006 and Beyond... reporting form or software, reporting instructions, and other associated documents as follows: (1) By website. Go to the EPA Inventory Update Reporting Internet home page at http://www.epa.gov/oppt/iur...

  3. 40 CFR 710.59 - Availability of reporting form and instructions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS Inventory Update Reporting for 2006 and Beyond... reporting form or software, reporting instructions, and other associated documents as follows: (1) By website. Go to the EPA Inventory Update Reporting Internet home page at http://www.epa.gov/oppt/iur...

  4. 40 CFR 711.25 - Recordkeeping requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Recordkeeping requirements. 711.25 Section 711.25 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL DATA REPORTING REQUIREMENTS § 711.25 Recordkeeping requirements. Each person...

  5. 40 CFR 711.10 - Activities for which reporting is not required.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Activities for which reporting is not required. 711.10 Section 711.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL DATA REPORTING REQUIREMENTS § 711.10 Activities for which reporting...

  6. 40 CFR 711.20 - When to report.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false When to report. 711.20 Section 711.20 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL DATA REPORTING REQUIREMENTS § 711.20 When to report. All information reported to EPA in...

  7. 40 CFR 711.9 - Persons not subject to this part.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Persons not subject to this part. 711.9 Section 711.9 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL DATA REPORTING REQUIREMENTS § 711.9 Persons not subject to this part....

  8. 40 CFR 711.22 - Duplicative reporting.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Duplicative reporting. 711.22 Section 711.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL DATA REPORTING REQUIREMENTS § 711.22 Duplicative reporting. (a) With regard to...

  9. 40 CFR 711.35 - Electronic filing.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Electronic filing. 711.35 Section 711.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL DATA REPORTING REQUIREMENTS § 711.35 Electronic filing. (a) You must use e-CDRweb...

  10. 40 CFR 711.1 - Scope and compliance.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Scope and compliance. 711.1 Section 711.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL DATA REPORTING REQUIREMENTS § 711.1 Scope and compliance. (a) This part...

  11. 75 FR 70665 - Proposed Significant New Use Rule for Cobalt Lithium Manganese Nickel Oxide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-18

    ... chemical substance. The extent to which a use increases the magnitude and duration of exposure of human... proposing a significant new use rule (SNUR) under section 5(a)(2) of the Toxic Substances Control Act (TSCA... identity or contact information unless you provide it in the body of your comment. If you......

  12. Microorganisms and Chemical Pollution

    ERIC Educational Resources Information Center

    Alexander, M.

    1973-01-01

    Discusses the importance of microorganisms in chemical pollution and pollution abatement. Selected chemical pollutants are chosen to illustrate that microorganisms synthesize hazardous substances from reasonably innocuous precursors, while others act as excellent environmental decontaminating agents by removing undesirable natural and synthetic…

  13. 78 FR 1832 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-09

    ... From the Federal Register Online via the Government Publishing Office CHEMICAL SAFETY AND HAZARD INVESTIGATION BOARD Sunshine Act Meeting TIME AND DATE: January 17, 2013; 2:30 p.m. EST. PLACE: Ronald Reagan.... STATUS: Open to the public. MATTERS TO BE CONSIDERED: The Chemical Safety and Hazard Investigation...

  14. 78 FR 6807 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-31

    ... From the Federal Register Online via the Government Publishing Office ] CHEMICAL SAFETY AND HAZARD INVESTIGATION BOARD Sunshine Act Meeting TIME AND DATE: February 7, 2013; 6:30 p.m. EST. PLACE: Seelbach Hilton...: The Chemical Safety and Hazard Investigation Board (CSB) announces that it will convene a...

  15. The new Clean Air Act

    SciTech Connect

    Padmanabha, A.P. ); Olem, H. )

    1991-05-01

    This article is a title by title review of the new Clean Air Act and how it affects water quality and wastewater treatment. The bill provides for restoring and protecting lakes and rivers by reducing acid-rain-causing emissions and toxics from nonpoint-source runoff. Topics covered include urban smog, mobile sources, air toxics, acid rain, permits, ozone-depleting chemicals, enforcement, and the law's socio-economic impacts.

  16. 48 CFR 1552.235-78 - Data Security for Toxic Substances Control Act Confidential Business Information (DEC 1997).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Security Staff in the OPPT, or by the EPA Project Officer. (3) The Contractor Document Control Officer (DCO... Relinquishing TSCA CBI Access Authority.” The Contractor DCO will also forward those agreements to the EPA...

  17. Toxic Chemical System (TCS)

    SciTech Connect

    Del Gandio, P.

    1994-09-01

    The Toxic Chemical System (TCS) will have the capacity to process chemical data, calculate chemical formulas, and format the data into the United States (US) Environmental Protection Agency (EPA) Toxic Chemical Release Inventory Reporting Form R of Section 313 of the Emergency Planning and Community Right-to-Know Act (EPCRA), hereafter be referred to as ``Form R.`` The filing of this form is required of all industries which manufacture, process or otherwise use any EPA listed chemicals in quantities in excess of their threshold planning quantities (TPQ). Facilities required to file the Form R must report the quantities of both routine and accidental releases of listed toxic chemicals on-site during the calendar year and the amount contained in waste products transferred off-site. This paper describes a specialized computer system designed for regulatory compliance.

  18. Compliance under the Community Right-to-Know Act

    SciTech Connect

    Bradford, J.R.; Vaughn, R.C.; Breazeale, A.

    1995-12-31

    In 1986, the Superfund Amendments and Reauthorization Act (SARA) provided additional funding to continue and greatly expand the cleanup program begun under CERCLA. Title III of SARA contains the provisions of the Emergency Planning and Community Right-to-Know Act (EPCRA). SARA Title III may prove to be more pervasive and more demanding for industry than any of the other many rules and regulations promulgated by the Environmental Protection Agency. The Emergency Planning and Community Right-to-Know Act has four major provisions: planning for chemical emergencies; emergency notification of chemical accidents and releases; reporting of hazardous chemical inventories; and toxic chemical release reporting.

  19. Recovery Act Milestones

    ScienceCinema

    Rogers, Matt

    2016-07-12

    Every 100 days, the Department of Energy is held accountable for a progress report on the American Recovery and Reinvestment Act. Update at 200 days, hosted by Matt Rogers, Senior Advisor to Secretary Steven Chu for Recovery Act Implementation.

  20. Recovery Act Milestones

    SciTech Connect

    Rogers, Matt

    2009-01-01

    Every 100 days, the Department of Energy is held accountable for a progress report on the American Recovery and Reinvestment Act. Update at 200 days, hosted by Matt Rogers, Senior Advisor to Secretary Steven Chu for Recovery Act Implementation.

  1. ACTS data center

    NASA Technical Reports Server (NTRS)

    Syed, Ali; Vogel, Wolfhard J.

    1993-01-01

    Viewgraphs on ACTS Data Center status report are included. Topics covered include: ACTS Data Center Functions; data flow overview; PPD flow; RAW data flow; data compression; PPD distribution; RAW Data Archival; PPD Audit; and data analysis.

  2. The dermatology acting internship.

    PubMed

    Stephens, John B; Raimer, Sharon S; Wagner, Richard F

    2011-07-15

    Acting internships are an important component of modern day medical school curriculum. Several specialties outside of internal medicine now offer acting internship experiences to fourth year medical students. We have found that a dermatology acting internship is a valuable experience for fourth year medical students who are interested in pursuing a residency in dermatology. Our experience with the dermatology acting internship over the 2010-2011 academic year is described.

  3. Forgetting ACT UP

    ERIC Educational Resources Information Center

    Juhasz, Alexandra

    2012-01-01

    When ACT UP is remembered as the pinnacle of postmodern activism, other forms and forums of activism that were taking place during that time--practices that were linked, related, just modern, in dialogue or even opposition to ACT UP's "confrontational activism"--are forgotten. In its time, ACT UP was embedded in New York City, and a larger world,…

  4. Act II of the Sunshine Act.

    PubMed

    Pham-Kanter, Genevieve

    2014-11-01

    To coincide with the introduction in the United States of the Sunshine Act, Genevieve Pham-Kanter discusses what we need to look for to fight hidden bias and deliberate or unconscious corruption. Please see later in the article for the Editors' Summary.

  5. 78 FR 20089 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-03

    ... From the Federal Register Online via the Government Publishing Office CHEMICAL SAFETY AND HAZARD INVESTIGATION BOARD Sunshine Act Meeting TIME AND DATE: The meeting will convene at 6:30 p.m. PDT on April 19, 2013. PLACE: The meeting will be held at Richmond Memorial Auditorium and Convention Center located...

  6. 77 FR 41741 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-16

    ... for Process Safety Performance Indicators for the Refining and Petrochemical Industries (ANSI/API RP... From the Federal Register Online via the Government Publishing Office CHEMICAL SAFETY AND HAZARD INVESTIGATION BOARD Sunshine Act Meeting In connection with its continued analysis of effective...

  7. 78 FR 55326 - Determinations Regarding Use of Chemical Weapons in Syria Under the Chemical and Biological...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-10

    ... Determinations Regarding Use of Chemical Weapons in Syria Under the Chemical and Biological Weapons Control and... to Section 306(a) of the Chemical and Biological Weapons Control and Warfare Elimination Act of 1991, 22 U.S.C. 5604(a), that the Government of Syria has used chemical weapons in violation...

  8. 25 CFR 700.33 - Act (The Act).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false Act (The Act). 700.33 Section 700.33 Indians THE OFFICE OF NAVAJO AND HOPI INDIAN RELOCATION COMMISSION OPERATIONS AND RELOCATION PROCEDURES General Policies and Instructions Definitions § 700.33 Act (The Act). (a) The Act. The Act is Pub. L. 93-531, (88...

  9. 25 CFR 700.33 - Act (The Act).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Act (The Act). 700.33 Section 700.33 Indians THE OFFICE OF NAVAJO AND HOPI INDIAN RELOCATION COMMISSION OPERATIONS AND RELOCATION PROCEDURES General Policies and Instructions Definitions § 700.33 Act (The Act). (a) The Act. The Act is Pub. L. 93-531, (88...

  10. 25 CFR 700.33 - Act (The Act).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false Act (The Act). 700.33 Section 700.33 Indians THE OFFICE OF NAVAJO AND HOPI INDIAN RELOCATION COMMISSION OPERATIONS AND RELOCATION PROCEDURES General Policies and Instructions Definitions § 700.33 Act (The Act). (a) The Act. The Act is Pub. L. 93-531, (88...

  11. 25 CFR 700.33 - Act (The Act).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false Act (The Act). 700.33 Section 700.33 Indians THE OFFICE OF NAVAJO AND HOPI INDIAN RELOCATION COMMISSION OPERATIONS AND RELOCATION PROCEDURES General Policies and Instructions Definitions § 700.33 Act (The Act). (a) The Act. The Act is Pub. L. 93-531, (88...

  12. Review of organic nitrile incineration at the Toxic Substances Control Act Incinerator

    SciTech Connect

    1997-10-01

    Lockheed Martin Energy Systems, Inc. (LMES) operates the East Tennessee Technology Park (ETTP), formerly called the Oak Ridge K-25 Site, where uranium was enriched under contract with the US Department of Energy (DOE). Currently, ETTP missions include environmental management, waste management (WM), and the development of new technologies. As part of its WM mission, ETTP operates the TSCA (Toxic Substances Control Act) Incinerator (TSCAI) for treatment of hazardous waste and polychlorinated biphenyls (PCBs) contaminated with low-level radioactivity. Beginning in the autumn of 1995, employees from diverse ETTP buildings and departments reported experiencing headaches, fatigue, depression, muscle aches, sleeplessness, and muscle tremors. These symptoms were judged by a physician in the ETTP Health Services Department to be consistent with chronic exposures to hydrogen cyanide (HCN). The National Institute for Occupational Safety and Health (NIOSH) was called in to perform a health hazard evaluation to ascertain whether the employees` illnesses were in fact caused by occupational exposure to HCN. The NIOSH evaluation found no patterns for employees` reported symptoms with respect to work location or department. NIOSH also conducted a comprehensive air sampling study, which did not detect airborne cyanides at the ETTP. Employees, however, expressed concerns that the burning of nitrile-bearing wastes at the TSCAI might have produced HCN as a combustion product. Therefore, LMES and DOE established a multidisciplinary team (TSCAI Technical Review Team) to make a more detailed review of the possibility that combustion of nitrile-bearing wastes at the TSCAI might have either released nitriles or created HCN as a product of incomplete combustion (PIC).

  13. ACT and College Success

    ERIC Educational Resources Information Center

    Bleyaert, Barbara

    2010-01-01

    What is the relationship between ACT scores and success in college? For decades, admissions policies in colleges and universities across the country have required applicants to submit scores from a college entrance exam, most typically the ACT (American College Testing) or SAT (Scholastic Aptitude Test). This requirement suggests that high school…

  14. Americans with Disabilities Act.

    ERIC Educational Resources Information Center

    Updating School Board Policies, 1992

    1992-01-01

    Addressed to school board members, this article attempts to summarize requirements of the Americans with Disabilities Act (ADA) and its implications for school districts. It warns against hasty purchase of private compliance assistance; then provides an overview of each of the Act's five Titles which address employment practices, activities…

  15. 76 FR 76935 - Impact of Implementing the Chemical Weapons Convention (CWC) on Commercial Activities Involving...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-09

    ... Bureau of Industry and Security Impact of Implementing the Chemical Weapons Convention (CWC) on... implementation of the Chemical Weapons Convention (CWC), through the Chemical Weapons Convention Implementation Act (CWCIA), and the Chemical Weapons Convention Regulations (CWCR), has had on commercial...

  16. Opportunities for artificial intelligence application in computer- aided management of mixed waste incinerator facilities

    SciTech Connect

    Rivera, A.L.; Ferrada, J.J.; Singh, S.P.N.

    1992-05-01

    The Department of Energy/Oak Ridge Field Office (DOE/OR) operates a mixed waste incinerator facility at the Oak Ridge K-25 Site. It is designed for the thermal treatment of incinerable liquid, sludge, and solid waste regulated under the Toxic Substances Control Act (TSCA) and the Resource Conservation and Recovery Act (RCRA). This facility, known as the TSCA Incinerator, services seven DOE/OR installations. This incinerator was recently authorized for production operation in the United States for the processing of mixed (radioactively contaminated-chemically hazardous) wastes as regulated under TSCA and RCRA. Operation of the TSCA Incinerator is highly constrained as a result of the regulatory, institutional, technical, and resource availability requirements. These requirements impact the characteristics and disposition of incinerator residues, limits the quality of liquid and gaseous effluents, limit the characteristics and rates of waste feeds and operating conditions, and restrict the handling of the waste feed inventories. This incinerator facility presents an opportunity for applying computer technology as a technical resource for mixed waste incinerator operation to facilitate promoting and sustaining a continuous performance improvement process while demonstrating compliance. Demonstrated computer-aided management systems could be transferred to future mixed waste incinerator facilities.

  17. Opportunities for artificial intelligence application in computer- aided management of mixed waste incinerator facilities

    SciTech Connect

    Rivera, A.L.; Ferrada, J.J.; Singh, S.P.N.

    1992-01-01

    The Department of Energy/Oak Ridge Field Office (DOE/OR) operates a mixed waste incinerator facility at the Oak Ridge K-25 Site. It is designed for the thermal treatment of incinerable liquid, sludge, and solid waste regulated under the Toxic Substances Control Act (TSCA) and the Resource Conservation and Recovery Act (RCRA). This facility, known as the TSCA Incinerator, services seven DOE/OR installations. This incinerator was recently authorized for production operation in the United States for the processing of mixed (radioactively contaminated-chemically hazardous) wastes as regulated under TSCA and RCRA. Operation of the TSCA Incinerator is highly constrained as a result of the regulatory, institutional, technical, and resource availability requirements. These requirements impact the characteristics and disposition of incinerator residues, limits the quality of liquid and gaseous effluents, limit the characteristics and rates of waste feeds and operating conditions, and restrict the handling of the waste feed inventories. This incinerator facility presents an opportunity for applying computer technology as a technical resource for mixed waste incinerator operation to facilitate promoting and sustaining a continuous performance improvement process while demonstrating compliance. Demonstrated computer-aided management systems could be transferred to future mixed waste incinerator facilities.

  18. 40 CFR 766.25 - Chemical substances for testing.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Chemical substances for testing. 766... SUBSTANCES CONTROL ACT DIBENZO-PARA-DIOXINS/DIBENZOFURANS Specific Chemical Testing/Reporting Requirements § 766.25 Chemical substances for testing. (a) Listing of chemical substances. Chemical...

  19. 40 CFR 766.25 - Chemical substances for testing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Chemical substances for testing. 766... SUBSTANCES CONTROL ACT DIBENZO-PARA-DIOXINS/DIBENZOFURANS Specific Chemical Testing/Reporting Requirements § 766.25 Chemical substances for testing. (a) Listing of chemical substances. Chemical...

  20. 40 CFR 766.25 - Chemical substances for testing.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Chemical substances for testing. 766... SUBSTANCES CONTROL ACT DIBENZO-PARA-DIOXINS/DIBENZOFURANS Specific Chemical Testing/Reporting Requirements § 766.25 Chemical substances for testing. (a) Listing of chemical substances. Chemical...

  1. ACTS mobile SATCOM experiments

    NASA Technical Reports Server (NTRS)

    Abbe, Brian S.; Frye, Robert E.; Jedrey, Thomas C.

    1993-01-01

    Over the last decade, the demand for reliable mobile satellite communications (satcom) for voice, data, and video applications has increased dramatically. As consumer demand grows, the current spectrum allocation at L-band could become saturated. For this reason, NASA and the Jet Propulsion Laboratory are developing the Advanced Communications Technology Satellites (ACTS) mobile terminal (AMT) and are evaluating the feasibility of K/Ka-band (20/30 GHz) mobile satcom to meet these growing needs. U.S. industry and government, acting as co-partners, will evaluate K/Ka-band mobile satcom and develop new technologies by conducting a series of applications-oriented experiments. The ACTS and the AMT testbed will be used to conduct these mobile satcom experiments. The goals of the ACTS Mobile Experiments Program and the individual experiment configurations and objectives are further presented.

  2. Assertive Community Treatment (ACT)

    MedlinePlus

    ... community treatment? Assertive community treatment (ACT) is a model of psychiatric care that can be very effective ... it the most. Similar to the “treatment team” model of an inpatient psychiatric unit, which includes nurses, ...

  3. The ACTS propagation program

    NASA Technical Reports Server (NTRS)

    Chakraborty, Dayamoy; Davarian, Faramaz

    1991-01-01

    The purpose of the Advanced Communications Technology Satellite (ACTS) is to demonstrate the feasibility of the Ka-band (20 and 30 GHz) spectrum for satellite communications, as well as to help maintain U.S. leadership in satellite communications. ACTS incorporates such innovative schemes as time division multiple access (TDMA), microwave and baseband switching, onboard regeneration, and adaptive application of coding during rain-fade conditions. The success or failure of the ACTS experiment will depend on how accurately the rain-fade statistics and fade dynamics can be predicted in order to derive an appropriate algorithm that will combat weather vagaries, specifically for links with small terminals, such as very small aperture terminals (VSAT's) where the power margin is a premium. This article describes the planning process and hardware development program that will comply with the recommendations of the ACTS propagation study groups.

  4. Chemical Reactors.

    ERIC Educational Resources Information Center

    Kenney, C. N.

    1980-01-01

    Describes a course, including content, reading list, and presentation on chemical reactors at Cambridge University, England. A brief comparison of chemical engineering education between the United States and England is also given. (JN)

  5. Chemical sensor

    NASA Technical Reports Server (NTRS)

    Rauh, R. David (Inventor)

    1990-01-01

    A sensor for detecting a chemical substance includes an insertion element having a structure which enables insertion of the chemical substance with a resulting change in the bulk electrical characteristics of the insertion element under conditions sufficient to permit effective insertion; the change in the bulk electrical characteristics of the insertion element is detected as an indication of the presence of the chemical substance.

  6. Safe drinking water act

    SciTech Connect

    Calabrese, E.J.; Gilbert, C.E. )

    1989-01-01

    This book covers drinking water regulations such as disinfectant by-products, synthetic organics, inorganic chemicals, microbiological contaminants, volatile organic chemicals, radionuclides, fluoride, toxicological approaches to setting new national drinking water regulations, and trihalomethanes. Gives organic and inorganic compounds scheduled to be regulated in 1989 and candidates for the 1990s regulations.

  7. The CEO's second act.

    PubMed

    Nadler, David A

    2007-01-01

    When a CEO leaves because of performance problems, the company typically recruits someone thought to be better equipped to fix what the departing executive couldn't--or wouldn't. The board places its confidence in the new person because of the present dilemma's similarity to some previous challenge that he or she dealt with successfully. But familiar problems are inevitably succeeded by less familiar ones, for which the specially selected CEO is not quite so qualified. More often than not, the experiences, skills, and temperament that yielded triumph in Act I turn out to be unequal to Act II's difficulties. In fact, the approaches that worked so brilliantly in Act I may be the very opposite of what is needed in Act II. The CEO has four choices: refuse to change, in which case he or she will be replaced; realize that the next act requires new skills and learn them; downsize or circumscribe his or her role to compensate for deficiencies; or line up a successor who is qualified to fill a role to which the incumbent's skills and interests are no longer suited. Hewlett-Packard's Carly Fiorina exemplifies the first alternative; Merrill Lynch's Stanley O'Neal the second; Google's Sergey Brin and Larry Page the third; and Quest Diagnostics' Ken Freeman the fourth. All but the first option are reasonable responses to the challenges presented in the second acts of most CEOs' tenures. And all but the first require a power of observation, a propensity for introspection, and a strain of humility that are rare in the ranks of the very people who need those qualities most. There are four essential steps executives can take to discern that they have entered new territory and to respond accordingly: recognition that their leadership style and approach are no longer working; acceptance of others' advice on why performance is faltering; analysis and understanding of the nature of the Act II shift; and, finally, decision and action.

  8. The CEO's second act.

    PubMed

    Nadler, David A

    2007-01-01

    When a CEO leaves because of performance problems, the company typically recruits someone thought to be better equipped to fix what the departing executive couldn't--or wouldn't. The board places its confidence in the new person because of the present dilemma's similarity to some previous challenge that he or she dealt with successfully. But familiar problems are inevitably succeeded by less familiar ones, for which the specially selected CEO is not quite so qualified. More often than not, the experiences, skills, and temperament that yielded triumph in Act I turn out to be unequal to Act II's difficulties. In fact, the approaches that worked so brilliantly in Act I may be the very opposite of what is needed in Act II. The CEO has four choices: refuse to change, in which case he or she will be replaced; realize that the next act requires new skills and learn them; downsize or circumscribe his or her role to compensate for deficiencies; or line up a successor who is qualified to fill a role to which the incumbent's skills and interests are no longer suited. Hewlett-Packard's Carly Fiorina exemplifies the first alternative; Merrill Lynch's Stanley O'Neal the second; Google's Sergey Brin and Larry Page the third; and Quest Diagnostics' Ken Freeman the fourth. All but the first option are reasonable responses to the challenges presented in the second acts of most CEOs' tenures. And all but the first require a power of observation, a propensity for introspection, and a strain of humility that are rare in the ranks of the very people who need those qualities most. There are four essential steps executives can take to discern that they have entered new territory and to respond accordingly: recognition that their leadership style and approach are no longer working; acceptance of others' advice on why performance is faltering; analysis and understanding of the nature of the Act II shift; and, finally, decision and action. PMID:17286076

  9. Chemical warfare agents.

    PubMed

    Chauhan, S; Chauhan, S; D'Cruz, R; Faruqi, S; Singh, K K; Varma, S; Singh, M; Karthik, V

    2008-09-01

    Chemical warfare agents (CWA's) are defined as any chemical substance whose toxic properties are utilised to kill, injure or incapacitate an enemy in warfare and associated military operations. Chemical agents have been used in war since times immemorial, but their use reached a peak during World War I. During World War II only the Germans used them in the infamous gas chambers. Since then these have been intermittently used both in war and acts of terrorisms. Many countries have stockpiles of these agents. There has been a legislative effort worldwide to ban the use of CWA's under the chemical weapons convention which came into force in 1997. However the manufacture of these agents cannot be completely prohibited as some of them have potential industrial uses. Moreover despite the remedial measures taken so far and worldwide condemnation, the ease of manufacturing these agents and effectiveness during combat or small scale terrorist operations still make them a powerful weapon to reckon with. These agents are classified according to mechanism of toxicity in humans into blister agents, nerve agents, asphyxiants, choking agents and incapacitating/behavior altering agents. Some of these agents can be as devastating as a nuclear bomb. In addition to immediate injuries caused by chemical agents, some of them are associated with long term morbidities and psychological problems. In this review we will discuss briefly about the historical background, properties, manufacture techniques and industrial uses, mechanism of toxicity, clinical features of exposure and pharmacological management of casualties caused by chemical agents. PMID:21783898

  10. ACTS broadband aeronautical terminal

    NASA Technical Reports Server (NTRS)

    Agan, M. J.; Densmore, A. C.

    1995-01-01

    This paper discusses the design of, and experiments with, the ACTS Broadband Aeronautical Terminal. As part of the ongoing effort to investigate commercial applications of ACTS technologies, NASA's Jet Propulsion Laboratory and various industry/government partners are developing a broadband mobile terminal for aeronautical applications. The ACTS Broadband Aeronautical Terminal is designed to explore the use of K/Ka-band for high data rate aeronautical satellite communications. Currently available commercial aeronautical satellite communications systems are only capable of achieving data rates on the order of tens of kilobits per second. The broadband terminal used in conjunction with the ACTS mechanically steerable antenna, can achieve data rates of 384 kilobits per second, while use of an ACTS spot beam antenna with this terminal will allow up to T1 data rates (1.544 megabits per second). The aeronautical terminal will be utilized to test a variety of applications that require a high data rate communications link. The use of the K/Ka-band for wideband aeronautical communications has the advantages of spectrum availability and smaller antennas, while eliminating the one major drawback of this frequency band, rain attenuation, by flying above the clouds the majority of the time.

  11. [Chemical weapons and chemical terrorism].

    PubMed

    Nakamura, Katsumi

    2005-10-01

    Chemical Weapons are kind of Weapons of Mass Destruction (WMD). They were used large quantities in WWI. Historically, large quantities usage like WWI was not recorded, but small usage has appeared now and then. Chemical weapons are so called "Nuclear weapon for poor countrys" because it's very easy to produce/possession being possible. They are categorized (1) Nerve Agents, (2) Blister Agents, (3) Cyanide (blood) Agents, (4) Pulmonary Agents, (5) Incapacitating Agents (6) Tear Agents from the viewpoint of human body interaction. In 1997 the Chemical Weapons Convention has taken effect. It prohibits chemical weapons development/production, and Organization for the Prohibition of Chemical Weapons (OPCW) verification regime contributes to the chemical weapons disposal. But possibility of possession/use of weapons of mass destruction by terrorist group represented in one by Matsumoto and Tokyo Subway Sarin Attack, So new chemical terrorism countermeasures are necessary.

  12. Affordable Care Act.

    PubMed

    Rak, Sofija; Coffin, Janis

    2013-01-01

    The Patient Protection and Affordable Care Act of 2010 (PPACA), although a subject of much debate in the Unites States, was enacted on March 23, 2010, and upheld by the Supreme Court on June 28, 2012. This act advocates that "healthcare is a right, not a privilege." The main goals of PPACA are to minimize the number of uninsured Americans and make healthcare available to everyone at an affordable price. The Congressional Budget Office has determined that 94% of Americans will have healthcare coverage while staying under the $900 billion limit that President Barack Obama established by bending the healthcare cost curve and reducing the deficit over the next 10 years. PMID:23767130

  13. Chemical microsensors

    DOEpatents

    Li, DeQuan; Swanson, Basil I.

    1995-01-01

    An article of manufacture is provided including a substrate having an oxide surface layer and a selective thin film of a cyclodextrin derivative chemically bound upon said substrate, said film is adapted for the inclusion of a selected organic compound therewith. Such an article can be either a chemical sensor capable of detecting a resultant mass change from inclusion of the selected organic compound or a chemical separator capable of reversibly selectively separating a selected organic compound.

  14. 40 CFR 799.19 - Chemical imports and exports.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the requirements of 40 CFR part 707. ... 40 Protection of Environment 32 2011-07-01 2011-07-01 false Chemical imports and exports. 799.19... CONTROL ACT (CONTINUED) IDENTIFICATION OF SPECIFIC CHEMICAL SUBSTANCE AND MIXTURE TESTING...

  15. 40 CFR 799.19 - Chemical imports and exports.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the requirements of 40 CFR part 707. ... 40 Protection of Environment 31 2010-07-01 2010-07-01 true Chemical imports and exports. 799.19... CONTROL ACT (CONTINUED) IDENTIFICATION OF SPECIFIC CHEMICAL SUBSTANCE AND MIXTURE TESTING...

  16. 40 CFR 799.19 - Chemical imports and exports.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the requirements of 40 CFR part 707. ... 40 Protection of Environment 33 2013-07-01 2013-07-01 false Chemical imports and exports. 799.19... CONTROL ACT (CONTINUED) IDENTIFICATION OF SPECIFIC CHEMICAL SUBSTANCE AND MIXTURE TESTING...

  17. 40 CFR 799.19 - Chemical imports and exports.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the requirements of 40 CFR part 707. ... 40 Protection of Environment 33 2012-07-01 2012-07-01 false Chemical imports and exports. 799.19... CONTROL ACT (CONTINUED) IDENTIFICATION OF SPECIFIC CHEMICAL SUBSTANCE AND MIXTURE TESTING...

  18. 40 CFR 799.19 - Chemical imports and exports.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the requirements of 40 CFR part 707. ... 40 Protection of Environment 32 2014-07-01 2014-07-01 false Chemical imports and exports. 799.19... CONTROL ACT (CONTINUED) IDENTIFICATION OF SPECIFIC CHEMICAL SUBSTANCE AND MIXTURE TESTING...

  19. Chemical Agents

    MedlinePlus

    ... glycol Hydrazine Hydrofluoric acid Hydrogen chloride Lewisite Melamine Mercury Methyl bromide Methyl isocyanate Nicotine Nitrogen mustard Opioids ... L-3) Long-acting anticoagulant (super warfarin) M Mercury Methyl bromide Methyl isocyanate Mustard gas (H) (sulfur ...

  20. Acts of Endearment

    PubMed Central

    Stephens, G. Gayle

    1992-01-01

    Legitimate and clinically useful affection between physicians and patients can be nurtured by attending to duties enjoined by traditional codes of ethics. Three acts of endearment have special importance for today's family physicians: smoothing the bed of death; keeping patients' secrets; and not abandoning patients on account of incurability. PMID:20469528

  1. Acting like a Pro

    ERIC Educational Resources Information Center

    Walker, Marlon A.

    2012-01-01

    The Saturday morning acting class in the Pearson Hall auditorium at Miles College boasts the school's highest attendance all year. The teacher, actress Robin Givens, was a lure few students--and others from surrounding areas--could resist. Some came to learn about their prospective field from a professional. Others were there for pointers to…

  2. The USA PATRIOT Act.

    ERIC Educational Resources Information Center

    Minow, Mary; Coyle, Karen; Kaufman, Paula

    2002-01-01

    Explains the USA PATRIOT (Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism) Act, passed after the September 11 terrorist attacks, and its implications for libraries and patron records. Considers past dealings with the FBI; court orders; search warrants; wiretaps; and subpoenas. Includes:…

  3. ACT against Violence.

    ERIC Educational Resources Information Center

    Anderson, M. Parker

    2001-01-01

    Describes how early childhood professionals can help young children avoid getting involved with violence or being exposed to violence. Presents information on the ACT [Adults and Children Together] Against Violence campaign, a national, multimedia campaign and a community-based training program developed in partnership by the National Association…

  4. Derwent's Doors: Creative Acts

    ERIC Educational Resources Information Center

    Gillen, Julia

    2007-01-01

    Children's early word learning is not usually considered creative in the same sense as artistic productions of later life. Yet early word learning is a creative response to the intrinsic instability of word meaning. As the child acts to participate in her community, she strives for intersubjectivity, manifest in neologisms and under- and…

  5. Improving America's Schools Act

    NASA Technical Reports Server (NTRS)

    Cradler, John; Bridgforth, Elizabeth

    1995-01-01

    The Improving America's Schools ACT (IASA) emphasizes coherent systemic education reform, with Goals 2000 setting common standards for IASA and the recently authorized School-to-Work Program. IASA addresses the need to raise academic achievement, increase opportunities to learn, improve professional development, increase community involvement, utilize instructional applications of technology, and improve assessment, and allow more local flexibility in the use of funds.

  6. Thyroid disrupting chemicals: Mechanisms and mixtures

    EPA Science Inventory

    Environmental contaminants are known to act as thyroid disrupting chemicals (TDCs). Broadly defined, TDCs are xenobiotics that alter the structure or function of the thyroid gland, alter regulatory enzymes associated with thyroid hormone (TH) homeostasis, or change circulating o...

  7. Protecting Communities from Chemical Explosions Act of 2013

    THOMAS, 113th Congress

    Sen. Lautenberg, Frank R. [D-NJ

    2013-04-25

    04/25/2013 Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  8. Continuing Chemical Facilities Antiterrorism Security Act of 2011

    THOMAS, 112th Congress

    Sen. Collins, Susan M. [R-ME

    2011-03-03

    10/20/2011 By Senator Lieberman from Committee on Homeland Security and Governmental Affairs filed written report. Report No. 112-90. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  9. Biological and Chemical Security

    SciTech Connect

    Fitch, P J

    2002-12-19

    The LLNL Chemical & Biological National Security Program (CBNP) provides science, technology and integrated systems for chemical and biological security. Our approach is to develop and field advanced strategies that dramatically improve the nation's capabilities to prevent, prepare for, detect, and respond to terrorist use of chemical or biological weapons. Recent events show the importance of civilian defense against terrorism. The 1995 nerve gas attack in Tokyo's subway served to catalyze and focus the early LLNL program on civilian counter terrorism. In the same year, LLNL began CBNP using Laboratory-Directed R&D investments and a focus on biodetection. The Nunn-Lugar-Domenici Defense Against Weapons of Mass Destruction Act, passed in 1996, initiated a number of U.S. nonproliferation and counter-terrorism programs including the DOE (now NNSA) Chemical and Biological Nonproliferation Program (also known as CBNP). In 2002, the Department of Homeland Security was formed. The NNSA CBNP and many of the LLNL CBNP activities are being transferred as the new Department becomes operational. LLNL has a long history in national security including nonproliferation of weapons of mass destruction. In biology, LLNL had a key role in starting and implementing the Human Genome Project and, more recently, the Microbial Genome Program. LLNL has over 1,000 scientists and engineers with relevant expertise in biology, chemistry, decontamination, instrumentation, microtechnologies, atmospheric modeling, and field experimentation. Over 150 LLNL scientists and engineers work full time on chemical and biological national security projects.

  10. Chemical sensors

    DOEpatents

    Lowell, J.R. Jr.; Edlund, D.J.; Friesen, D.T.; Rayfield, G.W.

    1991-07-02

    Sensors responsive to small changes in the concentration of chemical species are disclosed. The sensors comprise a mechanochemically responsive polymeric film capable of expansion or contraction in response to a change in its chemical environment. They are operatively coupled to a transducer capable of directly converting the expansion or contraction to a measurable electrical response. 9 figures.

  11. Chemical Peels

    MedlinePlus

    ... the complications or potential side effects of a chemical peel? Temporary or permanent change in skin color, particularly for women on birth control pills, who subsequently become pregnant or have a history of brownish facial ... after having a chemical peel? All peels require some follow-up care: ...

  12. Chemical preconcentrator

    DOEpatents

    Manginell, Ronald P.; Frye-Mason, Gregory C.

    2001-01-01

    A chemical preconcentrator is disclosed with applications to chemical sensing and analysis. The preconcentrator can be formed by depositing a resistive heating element (e.g. platinum) over a membrane (e.g. silicon nitride) suspended above a substrate. A coating of a sorptive material (e.g. a microporous hydrophobic sol-gel coating or a polymer coating) is formed on the suspended membrane proximate to the heating element to selective sorb one or more chemical species of interest over a time period, thereby concentrating the chemical species in the sorptive material. Upon heating the sorptive material with the resistive heating element, the sorbed chemical species are released for detection and analysis in a relatively high concentration and over a relatively short time period. The sorptive material can be made to selectively sorb particular chemical species of interest while not substantially sorbing other chemical species not of interest. The present invention has applications for use in forming high-sensitivity, rapid-response miniaturized chemical analysis systems (e.g. a "chem lab on a chip").

  13. Chemical sensors

    DOEpatents

    Lowell, Jr., James R.; Edlund, David J.; Friesen, Dwayne T.; Rayfield, George W.

    1991-01-01

    Sensors responsive to small changes in the concentration of chemical species are disclosed, comprising (a) a mechanochemically responsive polymeric film capable of expansion or contraction in response to a change in its chemical environment, operatively coupled to (b) a transducer capable of directly converting said expansion or contraction to a measurable electrical response.

  14. Chemical Emergencies

    MedlinePlus

    ... agents such as sarin and VX. Many hazardous chemicals are used in industry - for example, chlorine, ammonia, and benzene. Some can be made from everyday items such as household cleaners. Although there are no guarantees of safety during a chemical emergency, you can take actions to protect yourself. ...

  15. Chemical threats.

    PubMed

    Fry, Donald E

    2006-06-01

    The use of chemical agents as military weapons has been recognized for many centuries but reached the most feared and publicized level during World War I. Considerable political effort has been exercised in the twentieth century to restrict military strategies with chemicals. However, considerable concern currently exists that chemical weapons may be used as agents in civilian terrorism. The distribution of acetaminophen tablets contaminated with potassium cyanide and the release of sarin in the Tokyo sub-way system show that larger-scale deployment of chemical agents can be a reality. This reality makes it necessary for civilian disaster-planning strategies to incorporate an understanding of chemical agents, their effects, and the necessary treatment.

  16. Multiple-mask chemical etching

    NASA Technical Reports Server (NTRS)

    Cannon, D. L.

    1969-01-01

    Multiple masking techniques use lateral etching to reduce the total area of the high etch-rate oxide exposed to the chemical etchant. One method uses a short-term etch to remove the top layer from the silicon oxide surface, another acts before the top layer is grown.

  17. 40 CFR 766.38 - Reporting on precursor chemical substances.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Reporting on precursor chemical... SUBSTANCES CONTROL ACT DIBENZO-PARA-DIOXINS/DIBENZOFURANS Specific Chemical Testing/Reporting Requirements § 766.38 Reporting on precursor chemical substances. (a) Identification of precursor chemical...

  18. 40 CFR 766.38 - Reporting on precursor chemical substances.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Reporting on precursor chemical... SUBSTANCES CONTROL ACT DIBENZO-PARA-DIOXINS/DIBENZOFURANS Specific Chemical Testing/Reporting Requirements § 766.38 Reporting on precursor chemical substances. (a) Identification of precursor chemical...

  19. 40 CFR 766.38 - Reporting on precursor chemical substances.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Reporting on precursor chemical... SUBSTANCES CONTROL ACT DIBENZO-PARA-DIOXINS/DIBENZOFURANS Specific Chemical Testing/Reporting Requirements § 766.38 Reporting on precursor chemical substances. (a) Identification of precursor chemical...

  20. 75 FR 37301 - Exempt Chemical Mixtures Containing Gamma-Butyrolactone

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-29

    ... chemical precursor. It can be either converted into GHB by a simple chemical reaction or efficiently... (which purport to demonstrate the scientific principle of an exothermic chemical reaction). Since the... ``Implementation of the Domestic Chemical Diversion Control Act of 1993 (DCDCA)'' (59 FR 51887, October 13,...

  1. ACTS of Education

    NASA Technical Reports Server (NTRS)

    Bauer, Robert; Krawczyk, Richard; Gargione, Frank; Kruse, Hans; Vrotsos, Pete (Technical Monitor)

    2002-01-01

    Now in its ninth year of operations, the Advanced Communications Technology Satellite (ACTS) program has continued, although since May 2000 in a new operations arrangement involving a university based consortium, the Ohio Consortium for Advanced Communications Technology (OCACT), While NASA has concluded its experimental intentions of ACTS, the spacecraft's ongoing viability has permitted its further operations to provide educational opportunities to engineering and communications students interested in satellite operations, as well as a Ka-band test bed for commercial interests in utilizing Kaband space communications. The consortium has reached its first year of operations. This generous opportunity by NASA has already resulted in unique educational opportunities for students in obtaining "hands-on" experience, such as, in satellite attitude control. An update is presented on the spacecraft and consortium operations.

  2. Freedom of Information Act

    USGS Publications Warehouse

    Newman, D.J.

    2012-01-01

    The Freedom of Information Act( FOIA), 5 U.S.C.§ 552, as amended, generally provides that any person has a right to request access to Federal agency records. The USGS proactively promotes information disclosure as inherent to its mission of providing objective science to inform decisionmakers and the general public. USGS scientists disseminate up-to-date and historical scientific data that are critical to addressing national and global priorities.

  3. Toxic Substances Control Act

    SciTech Connect

    Not Available

    1992-05-15

    This Reference Book contains a current copy of the Toxic Substances Control Act and those regulations that implement the statute and appear to be most relevant to DOE activities. The document is provided to DOE and contractor staff for informational purposes only and should not be interpreted as legal guidance. Questions concerning this Reference Book may be directed to Mark Petts, EH-231 (202/586-2609).

  4. [Patients' Rights Act].

    PubMed

    Haier, A J

    2016-09-01

    The new Patients' Rights Act does not reflect rights of patients as professional obligations of physicians for the first time. It adopted common longtime jurisdiction, but in some respects it is going beyond. This law clearly extended the documentation requirements of physicians, especially concerning the extent of documentation. In surgical fields the requirements for enlightening physicians were more strongly worded than in previous jurisdiction. In medical facilities it is now mandatory to establish an internal quality management system. PMID:27626814

  5. ACTE Wing Loads Analysis

    NASA Technical Reports Server (NTRS)

    Horn, Nicholas R.

    2015-01-01

    The Adaptive Compliant Trailing Edge (ACTE) project modified a Gulfstream III (GIII) aircraft with a new flexible flap that creates a seamless transition between the flap and the wing. As with any new modification, it is crucial to ensure that the aircraft will not become overstressed in flight. To test this, Star CCM a computational fluid dynamics (CFD) software program was used to calculate aerodynamic data for the aircraft at given flight conditions.

  6. The ACTS multibeam antenna

    NASA Technical Reports Server (NTRS)

    Regier, Frank A.

    1992-01-01

    The Advanced Communications Technology Satellite (ACTS) to be launched in 1993 introduces several new technologies including a multibeam antenna (MBA) operating at Ka-band. The satellite is introduced briefly, and then the MBA, consisting of electrically similar 30 GHz received and 20 GHz transmit offset Cassegrain systems utilizing orthogonal linear polarizations, is described. Dual polarization is achieved by using one feed assembly for each polarization in conjunction with nested front and back subreflectors, the gridded front subreflector acting as a window for one polarization and a reflector for the other. The antennas produce spot beams with approximately 0.3 deg beamwidth and gains of approximately 50 dbi. High surface accuracy and high edge taper produce low sidelobe levels and high cross-polarization isolation. A brief description is given of several Ka-band components fabricated for ACTS. These include multiflare antenna feedhorns, beam-forming networks utilizing latching ferrite waveguide switches, a 30 GHz high mobility electron transmitter (HEMT) low-noise amplifier and a 20 GHz TWT power amplifier.

  7. 77 FR 59891 - Proposed Information Collection; Comment Request; Chemical Weapons Convention Declaration and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... Bureau of Industry and Security Proposed Information Collection; Comment Request; Chemical Weapons...@bis.doc.gov . SUPPLEMENTARY INFORMATION: ] I. Abstract The Chemical Weapons Convention Implementation Act of 1998 and Commerce Chemical Weapons Convention Regulations (CWCR) specify the...

  8. Chemical genetics and regeneration.

    PubMed

    Sengupta, Sumitra; Zhang, Liyun; Mumm, Jeff S

    2015-01-01

    Regeneration involves interactions between multiple signaling pathways acting in a spatially and temporally complex manner. As signaling pathways are highly conserved, understanding how regeneration is controlled in animal models exhibiting robust regenerative capacities should aid efforts to stimulate repair in humans. One way to discover molecular regulators of regeneration is to alter gene/protein function and quantify effect(s) on the regenerative process: dedifferentiation/reprograming, stem/progenitor proliferation, migration/remodeling, progenitor cell differentiation and resolution. A powerful approach for applying this strategy to regenerative biology is chemical genetics, the use of small-molecule modulators of specific targets or signaling pathways. Here, we review advances that have been made using chemical genetics for hypothesis-focused and discovery-driven studies aimed at furthering understanding of how regeneration is controlled.

  9. Chemical peeling.

    PubMed

    Forte, R; Hack, J; Jackson, I T

    1993-01-01

    This article explores the wide range of chemical facial peels, which include phenol, trichloroacetic acid, and alpha-hydroxy acids. The application of these substances will be described in addition to the contraindications to this type of treatment.

  10. Unnecessary Chemicals

    ERIC Educational Resources Information Center

    Johnson, Anita

    1978-01-01

    Discusses the health hazards resulting from chemical additions of many common products such as cough syrups, food dyes, and cosmetics. Steps being taken to protect consumers from these health hazards are included. (MDR)

  11. Chemical sensors

    DOEpatents

    Lowell, J.R. Jr.; Edlund, D.J.; Friesen, D.T.; Rayfield, G.W.

    1992-06-09

    Sensors responsive to small changes in the concentration of chemical species are disclosed, comprising a mechanicochemically responsive polymeric film capable of expansion or contraction in response to a change in its chemical environment, either operatively coupled to a transducer capable of directly converting the expansion or contraction to a measurable electrical or optical response, or adhered to a second inert polymeric strip, or doped with a conductive material. 12 figs.

  12. Chemical sensors

    DOEpatents

    Lowell, Jr., James R.; Edlund, David J.; Friesen, Dwayne T.; Rayfield, George W.

    1992-01-01

    Sensors responsive to small changes in the concentration of chemical species are disclosed, comprising a mechanicochemically responsive polymeric film capable of expansion or contraction in response to a change in its chemical environment, either operatively coupled to a transducer capable of directly converting the expansion or contraction to a measurable electrical or optical response, or adhered to a second inert polymeric strip, or doped with a conductive material.

  13. 40 CFR 799.9420 - TSCA carcinogenicity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... shall be assigned a unique identification number. Dead animals, their preserved organs and tissues, and..., fissures. (2) Exudate/crust (eschar). (3) nonviable (dead) tissues. (4) Anything leading to destruction of... zone. During the exposure period, the actual concentrations of the test substance should be held...

  14. 40 CFR 799.9420 - TSCA carcinogenicity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... shall be assigned a unique identification number. Dead animals, their preserved organs and tissues, and..., fissures. (2) Exudate/crust (eschar). (3) nonviable (dead) tissues. (4) Anything leading to destruction of... zone. During the exposure period, the actual concentrations of the test substance should be held...

  15. 40 CFR 799.9420 - TSCA carcinogenicity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... shall be assigned a unique identification number. Dead animals, their preserved organs and tissues, and..., fissures. (2) Exudate/crust (eschar). (3) nonviable (dead) tissues. (4) Anything leading to destruction of... zone. During the exposure period, the actual concentrations of the test substance should be held...

  16. 40 CFR 799.9420 - TSCA carcinogenicity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... shall be assigned a unique identification number. Dead animals, their preserved organs and tissues, and..., fissures. (2) Exudate/crust (eschar). (3) nonviable (dead) tissues. (4) Anything leading to destruction of... zone. During the exposure period, the actual concentrations of the test substance should be held...

  17. 40 CFR 799.9780 - TSCA immunotoxicity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 CFR 799.9346. The exposure time for the anti-SRBC test shall be at least 28 days. (6) Observation... levels. (3) Test report. In addition to the reporting requirements as specified under 40 CFR part 792... study shall be conducted in compliance with the 40 CFR Part 792—Good Laboratory Practice. (j)...

  18. 40 CFR 799.9780 - TSCA immunotoxicity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 CFR 799.9346. The exposure time for the anti-SRBC test shall be at least 28 days. (6) Observation... levels. (3) Test report. In addition to the reporting requirements as specified under 40 CFR part 792... study shall be conducted in compliance with the 40 CFR Part 792—Good Laboratory Practice. (j)...

  19. 40 CFR 799.9780 - TSCA immunotoxicity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 CFR 799.9346. The exposure time for the anti-SRBC test shall be at least 28 days. (6) Observation... levels. (3) Test report. In addition to the reporting requirements as specified under 40 CFR part 792... study shall be conducted in compliance with the 40 CFR Part 792—Good Laboratory Practice. (j)...

  20. 40 CFR 799.9780 - TSCA immunotoxicity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 CFR 799.9346. The exposure time for the anti-SRBC test shall be at least 28 days. (6) Observation... levels. (3) Test report. In addition to the reporting requirements as specified under 40 CFR part 792... study shall be conducted in compliance with the 40 CFR Part 792—Good Laboratory Practice. (j)...

  1. 40 CFR 799.9420 - TSCA carcinogenicity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... sacrifices are planned, the number shall be increased by the number of animals scheduled to be sacrificed... lot of the test substance should be used, if possible, throughout the duration of the study, and the... in administering the test substance, a vehicle control group.......

  2. 40 CFR 799.9780 - TSCA immunotoxicity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... properties of the test substance. It is recommended that an aqueous solution should be used. If solubility is.... (ii) One lot of the test substance shall be used, if possible, throughout the duration of the study... of the animal's body weight. (iii) If the test substance is......

  3. ITC-CMA partnership and data needs for alkylphenols and ethoxylates

    USGS Publications Warehouse

    Rattner, B.A.; Rice, C.P.; Walker, J.D.

    1996-01-01

    The ITC has been an independent advisory committee to the EPA Administrator since enactment of the Toxics Substances Control Act (TSCA) in 1976. The ITC identifies and coordinates U.S. Government data needs for TSCA-regulable chemicals, and makes recommendations to the Administrator for priority testing consideration. Chemicals recommended by the ITC are added to the TSCA Priority Testing List that is revised semi-annually in Reports to the Administrator. In recent Reports, the ITC added alkylphenols (APs) and ethoxylates to the Priority Testing List. About 500 million pounds are produced annually for industrial processing, cleaning and personal care products. APs have been detected in the tissues of fish from the Great Lakes, and one AP (nonylphenol) causes vitellogenin gene expression in trout hepatocytes. Numerous APs and ethoxylates were recommended by the ITC because data are needed on: (1) chemical composition, (2) environmental fate of parent chemicals and impurities, and (3) health and ecological effects (including toxicokinetics and endocrine-modulating effects). In response to the ITC's recommendations, two activities have ensued. First, the EPA promulgated rules requiring manufacturers, importers and processors of APs and ethoxylates to submit production and exposure reports, and unpublished health and safety studies, for review. Second, the Alkylphenols and Ethoxylates Panel of Chemical Manufacturers Association (CMA) and the ITC formed a Dialogue Group to discuss the data needs. Data needs and activities initiated by the Dialogue Group will be presented.

  4. Guidance on the management of polychlorinated biphenyls (PCBs)

    SciTech Connect

    Not Available

    1993-11-01

    Polychlorinated biphenyls (PCBs) are a class of synthetic organic chemicals including 209 known isomers, each with from 1 to 10 chlorine atoms on a biphenyl ring. PCBs have a number of desirable properties for industrial applications including thermal stability, flame retardance, and low vapor pressure. Because of these properties, PCBs were widely used as dielectric fluid in electrical equipment such as utility transformers and capacitors. PCBs were also extensively used in hydraulic fluid and heat transfer fluid, in gaskets, as additives in cutting oils and lubricant, and in a variety of other uses. The Toxic Substances Control Act (TSCA) banned the manufacture of PCBs after 1978 in response to emerging information about the adverse health effects of PCBs and their persistence in the environment. In addition, TSCA directed the Administrator of the Environmental Protection Agency (EPA) to prescribe methods for disposal of PCBS, require marking of PCBs with warning labels, and control their use. The TSCA regulations allow continued use of PCBs provided that the use is totally enclosed and does not pose a risk to human health or the environment. However, at the end of their useful life, all PCB materials must be disposed of according to the TSCA regulations. This guidance document uses graphics and flow charts where possible to present the TSCA regulations according to management activities such as use, storage, disposal, and spill cleanup. The document is designed to be read on an as-needed basis; that is, each chapter can stand alone or may be read in combination with others to help the reader determine the regulations relevant to his or her individual situation and needs. Every attempt has been made to include the requirements of other statutes and regulations that apply to PCB materials and provide references for the reader to consult for additional information.

  5. ACTS broadband aeronautical experiment

    NASA Technical Reports Server (NTRS)

    Abbe, Brian S.; Jedrey, Thomas C.; Estabrook, Polly; Agan, Martin J.

    1993-01-01

    In the last decade, the demand for reliable data, voice, and video satellite communication links between aircraft and ground to improve air traffic control, airline management, and to meet the growing demand for passenger communications has increased significantly. It is expected that in the near future, the spectrum required for aeronautical communication services will grow significantly beyond that currently available at L-band. In anticipation of this, JPL is developing an experimental broadband aeronautical satellite communications system that will utilize NASA's Advanced Communications Technology Satellite (ACTS) as a satellite of opportunity and the technology developed under JPL's ACTS Mobile Terminal (AMT) Task to evaluate the feasibility of using K/Ka-band for these applications. The application of K/Ka-band for aeronautical satellite communications at cruise altitudes is particularly promising for several reasons: (1) the minimal amount of signal attenuation due to rain; (2) the reduced drag due to the smaller K/Ka-band antennas (as compared to the current L-band systems); and (3) the large amount of available bandwidth. The increased bandwidth available at these frequencies is expected to lead to significantly improved passenger communications - including full-duplex compressed video and multiple channel voice. A description of the proposed broadband experimental system will be presented including: (1) applications of K/Ka-band aeronautical satellite technology to U.S. industry; (2) the experiment objectives; (3) the experiment set-up; (4) experimental equipment description; and (5) industrial participation in the experiment and the benefits.

  6. Chemical sensors

    SciTech Connect

    Hubbard, C.W.; Gordon, R.L.

    1987-05-01

    The revolution in analytical chemistry promised by recent developments in the field of chemical sensors has potential for significant positive impact on both research and production activities conducted by and for the Department of Energy. Analyses which were, in the past, performed only with a roomful of expensive equipment can now be performed with miniature solid-state electronic devices or small optical probes. Progress in the development of chemical sensors has been rapid, and the field is currently growing at a great rate. In accordance, Pacific Northwest Laboratory initiated a survey of recent literature so that contributors to active programs in research on analytical methods could be made aware of principles and applications of this new technology. This report presents the results of that survey. The sensors discussed here are divided into three types: micro solid-state devices, optical sensors, and piezoelectric crystal devices. The report is divided into three corresponding sections. The first section, ''Micro Solid-State Devices,'' discusses the design, operation, and application of electronic sensors that are produced in much the same way as standard solid-state electronic devices. The second section, ''Optrodes,'' covers the design and operation of chemical sensors that use fiber optics to detect chemically induced changes in optical properties. The final section, ''Piezoelectric Crystal Detectors,'' discusses two types of chemical sensors that depend on the changes in the properties of an oscillating piezoelectric crystal to detect the presence of certain materials. Advantages and disadvantages of each type of sensor are summarized in each section.

  7. Affordable Care Act and Women

    MedlinePlus

    ... Privacy Policy FOIA Plain Writing Act No Fear Act Disclaimers Viewers & Players Assistant Secretary for Planning and Evaluation, Room 415F U.S. Department of Health and Human Services 200 Independence Avenue, SW Washington, D.C. ...

  8. Advanced Communications Technology Satellite (ACTS)

    NASA Technical Reports Server (NTRS)

    Schertler, Ronald J.; Gedney, Richard T.

    1992-01-01

    An overview of the NASA ACTS program is presented. The key technologies of ACTS include spot beams, on-board baseband processing and routing, wide bandwidth (900 MHz), and Ka-band transponders. The discussion covers system description, current status of the spacecraft development, ACTS earth stations, NGS traffic terminal, USAT, land and aeronautical mobiles, high data rate and propagation receive only terminals, and ACTS experiments program.

  9. The Nurse Reinvestment Act revisited.

    PubMed

    Luther, Ann P

    2007-01-01

    The United States is in the midst of a widely recognized critical nursing shortage. In 2002 the "Nurse Reinvestment Act" was passed with overwhelming bipartisan support in an effort to address this serious public health threat. The Act is due for reauthorization of funding in 2007. This paper provides a brief overview of the programs contained within the Act and describes practical ways in which members of the nursing community can take action to insure renewed support for the Act. PMID:17691598

  10. Chemical networks

    NASA Astrophysics Data System (ADS)

    Thi, Wing-Fai

    2015-09-01

    This chapter discusses the fundamental ideas of how chemical networks are build, their strengths and limitations. The chemical reactions that occur in disks combine the cold phase reactions used to model cold molecular clouds with the hot chemistry applied to planetary atmosphere models. With a general understanding of the different types of reactions that can occur, one can proceed in building a network of chemical reactions and use it to explain the abundance of species seen in disks. One on-going research subject is finding new paths to synthesize species either in the gas-phase or on grain surfaces. Specific formation routes for water or carbon monoxide are discussed in more details. 13th Lecture of the Summer School "Protoplanetary Disks: Theory and Modelling Meet Observations"

  11. FCC and the Sunshine Act.

    ERIC Educational Resources Information Center

    Weiss, Kenneth

    The Sunshine Act, designed to encourage open meetings to increase public understanding of the governmental decision-making process, went into effect in March 1977. A total of 50 agencies, including the Federal Communications Commission (FCC), are subject to the provisions of the Sunshine Act. The act lists 10 exemptions, any of which can result in…

  12. ACT/SAT College Survey.

    ERIC Educational Resources Information Center

    Stafford, John E.

    1998-01-01

    Reports on findings of a survey designed to discover whether higher education institutions' admission standards accept SAT I or ACT and if there is preference for either, and whether ACT could be submitted in lieu of SAT II subject tests. Eighty-six percent of the reporting schools indicated no preference; 28 schools indicated that the ACT was an…

  13. 40 CFR 790.65 - Failure to comply with a consent agreement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SUBSTANCES CONTROL ACT (CONTINUED) PROCEDURES GOVERNING TESTING CONSENT AGREEMENTS AND TEST RULES... a consent agreement to be a “prohibited act” under section 15 of TSCA, subject to all of the provisions of the Act applicable to violations of section 15. Section 15(1) of TSCA makes it unlawful for...

  14. Triple acting radial seal

    DOEpatents

    Ebert, Todd A; Carella, John A

    2012-03-13

    A triple acting radial seal used as an interstage seal assembly in a gas turbine engine, where the seal assembly includes an interstage seal support extending from a stationary inner shroud of a vane ring, the interstage seal support includes a larger annular radial inward facing groove in which an outer annular floating seal assembly is secured for radial displacement, and the outer annular floating seal assembly includes a smaller annular radial inward facing groove in which an inner annular floating seal assembly is secured also for radial displacement. A compliant seal is secured to the inner annular floating seal assembly. The outer annular floating seal assembly encapsulates the inner annular floating seal assembly which is made from a very low alpha material in order to reduce thermal stress.

  15. FAST ACTING CURRENT SWITCH

    DOEpatents

    Batzer, T.H.; Cummings, D.B.; Ryan, J.F.

    1962-05-22

    A high-current, fast-acting switch is designed for utilization as a crowbar switch in a high-current circuit such as used to generate the magnetic confinement field of a plasma-confining and heat device, e.g., Pyrotron. The device particularly comprises a cylindrical housing containing two stationary, cylindrical contacts between which a movable contact is bridged to close the switch. The movable contact is actuated by a differential-pressure, airdriven piston assembly also within the housing. To absorb the acceleration (and the shock imparted to the device by the rapidly driven, movable contact), an adjustable air buffer assembly is provided, integrally connected to the movable contact and piston assembly. Various safety locks and circuit-synchronizing means are also provided to permit proper cooperation of the invention and the high-current circuit in which it is installed. (AEC)

  16. Chemical Mahjong

    ERIC Educational Resources Information Center

    Cossairt, Travis J.; Grubbs, W. Tandy

    2011-01-01

    An open-access, Web-based mnemonic game is described whereby introductory chemistry knowledge is tested using mahjong solitaire game play. Several tile sets and board layouts are included that are themed upon different chemical topics. Introductory tile sets can be selected that prompt the player to match element names to symbols and metric…

  17. Delicious Chemicals.

    ERIC Educational Resources Information Center

    Barry, Dana M.

    This paper presents an approach to chemistry and nutrition that focuses on food items that people consider delicious. Information is organized according to three categories of food chemicals that provide energy to the human body: (1) fats and oils; (2) carbohydrates; and (3) proteins. Minerals, vitamins, and additives are also discussed along with…

  18. Chemical Indicators.

    ERIC Educational Resources Information Center

    Prombain, Dorothy R.; And Others

    This science sourcebook was written for intermediate grade teachers to provide guidance in teaching a specially developed unit on chemical indicators. Directions and suggestions for guiding student science activities are given. Some of the activities concern soil testing, crystals, and household powders such as sugar and salt. A list of necessary…

  19. Programmability of Chemical Reaction Networks

    NASA Astrophysics Data System (ADS)

    Cook, Matthew; Soloveichik, David; Winfree, Erik; Bruck, Jehoshua

    Motivated by the intriguing complexity of biochemical circuitry within individual cells we study Stochastic Chemical Reaction Networks (SCRNs), a formal model that considers a set of chemical reactions acting on a finite number of molecules in a well-stirred solution according to standard chemical kinetics equations. SCRNs have been widely used for describing naturally occurring (bio)chemical systems, and with the advent of synthetic biology they become a promising language for the design of artificial biochemical circuits. Our interest here is the computational power of SCRNs and how they relate to more conventional models of computation. We survey known connections and give new connections between SCRNs and Boolean Logic Circuits, Vector Addition Systems, Petri nets, Gate Implementability, Primitive Recursive Functions, Register Machines, Fractran, and Turing Machines. A theme to these investigations is the thin line between decidable and undecidable questions about SCRN behavior.

  20. Chemicals, Cancer and Cancer Biology

    PubMed Central

    Smuckler, Edward A.

    1983-01-01

    Chemicals can cause cancer in humans and animals. Two significant questions are how and how frequently do these neoplasms arise? The first documentation of chemically induced cancer in humans was of the occupationally related “soot wart” in 1775. Since that time various carcinogens have been identified. Some compounds act directly on cell populations, whereas others must be metabolized by a host to produce a “proximate” or “ultimate” carcinogen. Because of the variety in carcinogen structure and the multiplicity of modifications to the cellular macromolecules, a simple explanation for chemical effect is unlikely. Furthermore, true neoplastic growth involves at least two and possibly more steps, some of which are reversible. Evidence suggests that cancer represents an altering of differentiation and that chemical agents may act at the level of DNA or on epigenetic regulatory phenomena. The method for selecting the neoplastic cell from those that are normal is not known. Because we cannot explain the mechanisms for cancer formation or the role of chemicals in the process, prudence is needed in determining the significance of human exposure and in relating this exposure to the risk of neoplastic disease. Images PMID:6624084

  1. Double acting bit holder

    DOEpatents

    Morrell, Roger J.; Larson, David A.; Ruzzi, Peter L.

    1994-01-01

    A double acting bit holder that permits bits held in it to be resharpened during cutting action to increase energy efficiency by reducing the amount of small chips produced. The holder consist of: a stationary base portion capable of being fixed to a cutter head of an excavation machine and having an integral extension therefrom with a bore hole therethrough to accommodate a pin shaft; a movable portion coextensive with the base having a pin shaft integrally extending therefrom that is insertable in the bore hole of the base member to permit the moveable portion to rotate about the axis of the pin shaft; a recess in the movable portion of the holder to accommodate a shank of a bit; and a biased spring disposed in adjoining openings in the base and moveable portions of the holder to permit the moveable portion to pivot around the pin shaft during cutting action of a bit fixed in a turret to allow front, mid and back positions of the bit during cutting to lessen creation of small chip amounts and resharpen the bit during excavation use.

  2. Acting to gain information

    NASA Technical Reports Server (NTRS)

    Rosenchein, Stanley J.; Burns, J. Brian; Chapman, David; Kaelbling, Leslie P.; Kahn, Philip; Nishihara, H. Keith; Turk, Matthew

    1993-01-01

    This report is concerned with agents that act to gain information. In previous work, we developed agent models combining qualitative modeling with real-time control. That work, however, focused primarily on actions that affect physical states of the environment. The current study extends that work by explicitly considering problems of active information-gathering and by exploring specialized aspects of information-gathering in computational perception, learning, and language. In our theoretical investigations, we analyzed agents into their perceptual and action components and identified these with elements of a state-machine model of control. The mathematical properties of each was developed in isolation and interactions were then studied. We considered the complexity dimension and the uncertainty dimension and related these to intelligent-agent design issues. We also explored active information gathering in visual processing. Working within the active vision paradigm, we developed a concept of 'minimal meaningful measurements' suitable for demand-driven vision. We then developed and tested an architecture for ongoing recognition and interpretation of visual information. In the area of information gathering through learning, we explored techniques for coping with combinatorial complexity. We also explored information gathering through explicit linguistic action by considering the nature of conversational rules, coordination, and situated communication behavior.

  3. 78 FR 16698 - Chemical Facility Anti-Terrorism Standards (CFATS) Chemical-Terrorism Vulnerability Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-18

    ... Information (CVI) for an additional 30 days for public comments. \\1\\ See 77 FR 74685. The 60-day Federal... statutory mandate at 72 FR 17688. Section 550 of the Homeland Security Appropriations Act of 2007 requires a... SECURITY Chemical Facility Anti-Terrorism Standards (CFATS) Chemical- Terrorism Vulnerability...

  4. 21 CFR 570.19 - Pesticide chemicals in processed foods.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Pesticide chemicals in processed foods. 570.19... chemicals in processed foods. When pesticide chemical residues occur in processed foods due to the use of... exemption granted or a tolerance prescribed under section 408 of the act, the processed food will not...

  5. 21 CFR 170.19 - Pesticide chemicals in processed foods.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Pesticide chemicals in processed foods. 170.19... chemicals in processed foods. When pesticide chemical residues occur in processed foods due to the use of... exemption granted or a tolerance prescribed under section 408 of the Act, the processed food will not...

  6. [Euthanasia and medical act].

    PubMed

    2011-05-01

    Right to life -as the prohibition of intentionally and arbitrarily taking life, even with authorization of the concerned one- is an internationally recognized right. In many countries, debate regarding euthanasia is more centered in its convenience, social acceptability and how it is regulated, than in its substantial legitimacy. Some argue that euthanasia should be included as part of clinical practice of health professionals, grounded on individual's autonomy claims-everyone having the liberty to choose how to live and how to die. Against this, others sustain that life has a higher value than autonomy, exercising autonomy without respecting the right to life would become a serious moral and social problem. Likewise, euthanasia supporters some-times claim a 'right to live with dignity', which must be understood as a personal obligation, referred more to the ethical than to the strictly legal sphere. In countries where it is already legalized, euthanasia practice has extended to cases where it is not the patient who requests this but the family or some healthcare professional, or even the legal system-when they think that the patient is living in a condition which is not worthy to live. Generalization of euthanasia possibly will end in affecting those who need more care, such as elder, chronically ill or dying people, damaging severely personal basic rights. Nature, purpose and tradition of medicine rule out the practice of euthanasia, which ought not be considered a medical act or legitimately compulsory for physicians. Today's medicine counts with effective treatments for pain and suffering, such as palliative care, including sedative therapy, which best preserves persons dignity and keeps safe the ethos of the medical profession.

  7. 78 FR 33096 - Agency Forms Undergoing Paperwork Reduction Act Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-03

    ... HUMAN SERVICES Centers for Disease Control and Prevention Agency Forms Undergoing Paperwork Reduction Act Review The Centers for Disease Control and Prevention (CDC) publishes a list of information... days of this notice. Proposed Project Spectrum of Flavoring Chemical-Related Lung...

  8. 75 FR 70929 - Agency Forms Undergoing Paperwork Reduction Act Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-19

    ... international network of laboratories that can respond to acts of biological, chemical, or radiological... Network--Existing collection in use without an OMB Control Number (Generic Clearance)--National Center for... Control Number (Generic clearance). The Laboratory Response Network (LRN) was established by...

  9. 75 FR 63703 - Privacy Act of 1974; Privacy Act Regulation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-18

    ... Federal Register, 73 FR 25594, May 7, 2008. The proposed amendments: (1) Waived all copying fees in..., 73 FR 54595, September 22, 2008, certain portions of BGFRS-37 (Electronic Applications) may be exempt... CFR Part 261a Privacy Act of 1974; Privacy Act Regulation AGENCY: Board of Governors of the...

  10. 78 FR 7777 - Information Collection Request Submitted to OMB for Review and Approval; Comment Request...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ...; Notification of Chemical Exports--TSCA Section 12(b) AGENCY: Environmental Protection Agency (EPA). ACTION... of Chemical Exports--TSCA Section 12(b)'' and identified as EPA ICR No. 0795.14 and OMB Control No... seq.), as prescribed in 5 CFR 1320.12. On May 7, 2012 (77 FR 26750), EPA sought comments on this...

  11. 75 FR 47589 - Agency Information Collection Activities; Proposed Collection; Comment Request; Correction of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-06

    ... Misreported Chemical Substances on the TSCA Inventory; EPA ICR No. 1741.06, OMB Control No. 2070-0145 AGENCY... (OMB). This ICR, entitled: ``Correction of Misreported Chemical Substances on the TSCA Inventory'' and identified by EPA ICR No. 1741.06 and OMB Control No. 2070-0145, is scheduled to expire on April 30,...

  12. 76 FR 49469 - Agency Information Collection Activities; Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-10

    ... companies that manufacture, process or import chemical substances, mixtures or categories. Title: TSCA..., importers and processors of chemical substances and mixtures must maintain records and submit reports to EPA... from chemical substances, mixtures and categories. PAIR requires chemical manufacturers and...

  13. 7 CFR 1170.2 - Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PRODUCT MANDATORY REPORTING § 1170.2 Act. Act means the Agricultural Marketing Act of 1946, 7 U.S.C. 1621 et seq., as amended by the Dairy Market Enhancement Act...

  14. 7 CFR 1170.2 - Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ORDERS; MILK), DEPARTMENT OF AGRICULTURE DAIRY PRODUCT MANDATORY REPORTING § 1170.2 Act. Act means the Agricultural Marketing Act of 1946, 7 U.S.C. 1621 et seq., as amended by the Dairy Market Enhancement Act...

  15. 7 CFR 1170.2 - Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PRODUCT MANDATORY REPORTING § 1170.2 Act. Act means the Agricultural Marketing Act of 1946, 7 U.S.C. 1621 et seq., as amended by the Dairy Market Enhancement Act...

  16. Implementing the Amended FOI Act.

    ERIC Educational Resources Information Center

    McClain, Wallis

    The Freedom of Information Act amendments, which became effective in February 1975, have so far yielded mixed results. This report provides an account of how different federal agencies are implementing this amended statute. Among the topics discussed are modifications of the original 1966 Freedom of Information Act, which were made in the attempt…

  17. Online Challenge versus Offline ACT

    ERIC Educational Resources Information Center

    Peckham, Irvin

    2010-01-01

    This article compares essays written in response to the ACT Essay prompt and a locally developed prompt used for placement. The two writing situations differ by time and genre: the ACT Essay is timed and argumentative; the locally developed is untimed and explanatory. The article analyzes the differences in student performance and predictive…

  18. Education Leaders Applaud ATTAIN Act

    ERIC Educational Resources Information Center

    Curriculum Review, 2007

    2007-01-01

    This article talks about Achievement Through Technology and Innovation (ATTAIN) Act, a bill introduced by Senators Bingaman (D-NM), Burr (R-NC), and Murray (D-WA) and applauded by a coalition of education and industry groups. The proposed ATTAIN Act is similar to its companion in the House (HR 2449), and builds upon the Enhancing Education Through…

  19. Nurse Reinvestment Act. Public Law.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC.

    This document contains the text of the Nurse Reinvestment Act, which amends the Public Health Service Act to address the increasing shortage of registered nurses by instituting a series of policies to improve nurse recruitment and nurse retention. Title I details two initiatives to boost recruitment of nurses. The first initiative includes the…

  20. Act of 13 March 1989.

    PubMed

    1989-01-01

    This document contains the text of a 1989 Act of Utah prohibiting surrogate parenthood agreements of any type. Surrogate mothers are the legal mothers of their children, and their husbands are the legal fathers. This Act has no impact on adoption laws. PMID:12344464

  1. 76 FR 59073 - Privacy Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-23

    ... From the Federal Register Online via the Government Publishing Office CENTRAL INTELLIGENCE AGENCY 32 CFR Part 1901 Privacy Act AGENCY: Central Intelligence Agency. ACTION: Proposed rule. SUMMARY: Consistent with the Privacy Act (PA), the Central Intelligence Agency (CIA) has undertaken and completed...

  2. Biomass Program Recovery Act Factsheet

    SciTech Connect

    2010-03-01

    The Biomass Program has awarded about $718 million in American Recovery and Reinvestment Act (Recovery Act) funds. The projects the Program is supporting are intended to: Accelerate advanced biofuels research, development, and demonstration; Speed the deployment and commercialization of advanced biofuels and bioproducts; Further the U.S. bioindustry through market transformation and creating or saving a range of jobs.

  3. Hazardous chemical tracking system (HAZ-TRAC)

    SciTech Connect

    Bramlette, J D; Ewart, S M; Jones, C E

    1990-07-01

    Westinghouse Idaho Nuclear Company, Inc. (WINCO) developed and implemented a computerized hazardous chemical tracking system, referred to as Haz-Trac, for use at the Idaho Chemical Processing Plant (ICPP). Haz-Trac is designed to provide a means to improve the accuracy and reliability of chemical information, which enhances the overall quality and safety of ICPP operations. The system tracks all chemicals and chemical components from the time they enter the ICPP until the chemical changes form, is used, or becomes a waste. The system runs on a Hewlett-Packard (HP) 3000 Series 70 computer. The system is written in COBOL and uses VIEW/3000, TurboIMAGE/DBMS 3000, OMNIDEX, and SPEEDWARE. The HP 3000 may be accessed throughout the ICPP, and from remote locations, using data communication lines. Haz-Trac went into production in October, 1989. Currently, over 1910 chemicals and chemical components are tracked on the system. More than 2500 personnel hours were saved during the first six months of operation. Cost savings have been realized by reducing the time needed to collect and compile reporting information, identifying and disposing of unneeded chemicals, and eliminating duplicate inventories. Haz-Trac maintains information required by the Superfund Amendment Reauthorization Act (SARA), the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) and the Occupational Safety and Health Administration (OSHA).

  4. Acting to let someone die.

    PubMed

    McGee, Andrew

    2015-02-01

    This paper examines the recent prominent view in medical ethics that withdrawing life-sustaining treatment (LST) is an act of killing. I trace this view to the rejection of the traditional claim that withdrawing LST is an omission rather than an act. Although that traditional claim is not as problematic as this recent prominent view suggests, my main claim is that even if we accepted that withdrawing LST should be classified as an act rather than as an omission, it could still be classified as letting die rather than killing. Even though omissions are contrasted with acts, letting die need not be, for one can let die by means of acts. The remainder of the paper is devoted to establishing this claim and addresses certain objections to it.

  5. 76 FR 14439 - No FEAR Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-16

    ... TRANSPARENCY BOARD No FEAR Act Notice AGENCY: Recovery Accountability and Transparency Board. ACTION: Notice... and Retaliation Act (No FEAR Act or Act), as implemented by Office of Personnel Management (OPM... No FEAR Act. See Public Law 107-174, codified at 5 U.S.C. 2301 note. One purpose of the Act is...

  6. Chemical locomotion.

    PubMed

    Paxton, Walter F; Sundararajan, Shakuntala; Mallouk, Thomas E; Sen, Ayusman

    2006-08-18

    Research into the autonomous motion of artificial nano- and microscale objects provides basic principles to explore possible applications, such as self-assembly of superstructures, roving sensors, and drug delivery. Although the systems described have unique propulsion mechanisms, motility in each case is made possible by the conversion of locally available chemical energy into mechanical energy. The use of catalysts onboard can afford nondissipative systems that are capable of directed motion. Key to the design of nano- and micromotors is the asymmetric placement of the catalyst: its placement in an environment containing a suitable substrate translates into non-uniform consumption of the substrate and distribution of reaction products, which results in the motility of the object. These same principles are exploited in nature to effect autonomous motion.

  7. 77 FR 37634 - Proposed Significant New Use Rule on Certain Chemical Substances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-22

    ... days before commencing that activity. In the Federal Register of April 25, 2012 (77 FR 24613) (FRL-9345... (55 FR 17376), EPA has decided that the intent of TSCA section 5(a)(1)(B) is best served by... of actions from review under Executive Order 12866, entitled Regulatory Planning and Review (58...

  8. Emergency planning and community Right-to-Know Act Section 312 tier two report forms

    SciTech Connect

    Evans, R.A.; Martin, K.J.

    1996-02-01

    This report, as part of the emergency planning and community Right-to-Know Act, consists of report forms on chemicals at the Y-12 Plant. Information includes inventories, storage areas, and physical/health hazards.

  9. 15 CFR 719.2 - Violations of the Act subject to administrative and criminal enforcement proceedings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ENFORCEMENT § 719.2 Violations of the Act subject to...

  10. 15 CFR 719.2 - Violations of the Act subject to administrative and criminal enforcement proceedings.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ENFORCEMENT § 719.2 Violations of the Act subject to...

  11. 40 CFR 745.87 - Enforcement and inspections.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Residential Property... permit entry or inspection as required by 40 CFR 745.87 and TSCA section 11 (15 U.S.C. 2610) is a... criminal sanctions pursuant to TSCA section 16 (15 U.S.C. 2615) for each violation. (e) Lead-based paint...

  12. 40 CFR 745.87 - Enforcement and inspections.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Residential Property... permit entry or inspection as required by 40 CFR 745.87 and TSCA section 11 (15 U.S.C. 2610) is a... criminal sanctions pursuant to TSCA section 16 (15 U.S.C. 2615) for each violation. (e) Lead-based paint...

  13. 40 CFR 745.87 - Enforcement and inspections.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Residential Property... permit entry or inspection as required by 40 CFR 745.87 and TSCA section 11 (15 U.S.C. 2610) is a... criminal sanctions pursuant to TSCA section 16 (15 U.S.C. 2615) for each violation. (e) Lead-based paint...

  14. 40 CFR 745.87 - Enforcement and inspections.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Residential Property... permit entry or inspection as required by 40 CFR 745.87 and TSCA section 11 (15 U.S.C. 2610) is a... criminal sanctions pursuant to TSCA section 16 (15 U.S.C. 2615) for each violation. (e) Lead-based paint...

  15. 40 CFR 745.87 - Enforcement and inspections.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Residential Property... permit entry or inspection as required by 40 CFR 745.87 and TSCA section 11 (15 U.S.C. 2610) is a... criminal sanctions pursuant to TSCA section 16 (15 U.S.C. 2615) for each violation. (e) Lead-based paint...

  16. Assessment & Commitment Tracking System (ACTS)

    2004-12-20

    The ACTS computer code provides a centralized tool for planning and scheduling assessments, tracking and managing actions associated with assessments or that result from an event or condition, and "mining" data for reporting and analyzing information for improving performance. The ACTS application is designed to work with the MS SQL database management system. All database interfaces are written in SQL. The following software is used to develop and support the ACTS application: Cold Fusion HTMLmore » JavaScript Quest TOAD Microsoft Visual Source Safe (VSS) HTML Mailer for sending email Microsoft SQL Microsoft Internet Information Server« less

  17. Assessment & Commitment Tracking System (ACTS)

    SciTech Connect

    Bryant, Robert A.; Childs, Teresa A.; Miller, Michael A.; Sellars, Kevin J.

    2004-12-20

    The ACTS computer code provides a centralized tool for planning and scheduling assessments, tracking and managing actions associated with assessments or that result from an event or condition, and "mining" data for reporting and analyzing information for improving performance. The ACTS application is designed to work with the MS SQL database management system. All database interfaces are written in SQL. The following software is used to develop and support the ACTS application: Cold Fusion HTML JavaScript Quest TOAD Microsoft Visual Source Safe (VSS) HTML Mailer for sending email Microsoft SQL Microsoft Internet Information Server

  18. UTILIZING INFORMATION COLLECTED UNDER THE CLEAN WATER ACT FOR PUBLIC HEALTH ANALYSIS

    EPA Science Inventory

    The Clean Water Act was established to "restore and maintain the chemical, physical, and biological integrity of the Nation's waters". Under Section 303(d) of the Clean Water Act, the U.S.Environmental Protection Agency collects information from each state regarding the intended ...

  19. 78 FR 23624 - Determination and Certification Under the Foreign Assistance Act Relating to the Largest...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Determination and Certification Under the Foreign Assistance Act Relating to the Largest Exporting and Importing Countries of Certain Precursor Chemicals Pursuant to Section 490(b)(1)(A) of the Foreign Assistance Act...

  20. In Silico Studies of the Toxcast Chemicals Interacting with Biomolecular targets

    EPA Science Inventory

    Molecular docking, a structure-based in silico tool for chemical library pre-screening in drug discovery, can be used to explore the potential toxicity of environmental chemicals acting at specific biomelcular targets.

  1. Prelinguistic Vocalizations Distinguish Pointing Acts

    ERIC Educational Resources Information Center

    Grunloh, Thomas; Liszkowski, Ulf

    2015-01-01

    The current study investigated whether point-accompanying characteristics, like vocalizations and hand shape, differentiate infants' underlying motives of prelinguistic pointing. We elicited imperative (requestive) and declarative (expressive and informative) pointing acts in experimentally controlled situations, and analyzed accompanying…

  2. Monitoring EERE's Recovery Act Portfolio

    SciTech Connect

    2011-01-01

    Performance monitoring of Recovery Act projects within EERE has been an ongoing effort. Project recipients have been reporting technical and financial progress to project officers on a quarterly basis.

  3. Self-acting shaft seals

    NASA Technical Reports Server (NTRS)

    Ludwig, L. P.

    1980-01-01

    Report reviews operating principles and design of self-acting seals. Influences of adverse operating conditions are considered also. Elements of analysis used in seal performance predictions are described and evaluated. Mathematical models for obtaining seal force balance and equilibrium film thickness are outlined. Self-acting seals are nonrubbing, have lower leakage rates than labyrinth seals, and are well suited for advanced aircraft engines.

  4. Interpreting Metabolomics Data to Mode of Action of Chemicals

    EPA Science Inventory

    Metabolomics approach utilizes high-throughput identification, quantification, and characterization of low molecular weight endogenous metabolites from numerous metabolic pathways. Exposure to environmental chemicals, which act through multiple mechanisms, cause perturbation of...

  5. Shedding Light on Synergistic Chemical Genetic Connections with Machine Learning.

    PubMed

    Ekins, Sean; Siqueira-Neto, Jair Lage

    2015-12-23

    Machine learning can be used to predict compounds acting synergistically, and this could greatly expand the universe of available potential treatments for diseases that are currently hidden in the dark chemical matter. PMID:27136350

  6. Chemical information science coverage in Chemical Abstracts.

    PubMed

    Wiggins, G

    1987-02-01

    For many years Chemical Abstracts has included in its coverage publications on chemical documentation or chemical information science. Although the bulk of those publications can be found in section 20 of Chemical Abstracts, many relevant articles were found scattered among 39 other sections of CA in 1984-1985. In addition to the scattering of references in CA, the comprehensiveness of Chemical Abstracts as a secondary source for chemical information science is called into question. Data are provided on the journals that contributed the most references on chemical information science and on the languages of publication of relevant articles.

  7. Clean Air Act: Senate mulls revision bill

    SciTech Connect

    Fairley, P.

    1995-12-13

    Senator Lauch Faircloth (R., NC) has circulated a draft summary of possible revisions of the Clean Air Act (CAA). Chemical industry sources say the proposal would provide some regulatory relief but fear that supporting Faircloth could jeopardize their relationship with EPA. Faircloth`s proposal addresses various controversial aspect of CAA`s Title V permit program including the monitoring and permit modification provisions. The proposal would also define a facility`s {open_quotes}potential to emit,{close_quotes} upon which Title V permits are based. In the past year EPA has substantially revised its Title V program to address complaints from industry, the states, and Congress that the monitoring and modification provisions were too burdensome.

  8. 7 CFR 33.1 - Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AUTHORITY OF THE EXPORT APPLE ACT Definitions § 33.1 Act. Act and Export Apple Act are synonymous and mean “An act to promote the foreign trade of the United States in apples to protect the reputation of American-grown apples in foreign markets, to prevent deception or misrepresentation as to the quality...

  9. 7 CFR 33.1 - Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AUTHORITY OF THE EXPORT APPLE ACT Definitions § 33.1 Act. Act and Export Apple Act are synonymous and mean “An act to promote the foreign trade of the United States in apples to protect the reputation of American-grown apples in foreign markets, to prevent deception or misrepresentation as to the quality...

  10. 7 CFR 33.1 - Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AUTHORITY OF THE EXPORT APPLE ACT Definitions § 33.1 Act. Act and Export Apple Act are synonymous and mean “An act to promote the foreign trade of the United States in apples to protect the reputation of American-grown apples in foreign markets, to prevent deception or misrepresentation as to the quality...

  11. 7 CFR 33.1 - Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AUTHORITY OF THE EXPORT APPLE ACT Definitions § 33.1 Act. Act and Export Apple Act are synonymous and mean “An act to promote the foreign trade of the United States in apples to protect the reputation of American-grown apples in foreign markets, to prevent deception or misrepresentation as to the quality...

  12. 7 CFR 33.1 - Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AUTHORITY OF THE EXPORT APPLE ACT Definitions § 33.1 Act. Act and Export Apple Act are synonymous and mean “An act to promote the foreign trade of the United States in apples to protect the reputation of American-grown apples in foreign markets, to prevent deception or misrepresentation as to the quality...

  13. 40 CFR 761.253 - Chemical analysis.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Chemical analysis. 761.253 Section 761.253 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT... Sample Sites, Collecting Surface Samples, and Analyzing Standard PCB Wipe Samples § 761.253...

  14. 40 CFR 761.253 - Chemical analysis.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Chemical analysis. 761.253 Section 761.253 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT... Sample Sites, Collecting Surface Samples, and Analyzing Standard PCB Wipe Samples § 761.253...

  15. 40 CFR 761.253 - Chemical analysis.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Chemical analysis. 761.253 Section 761.253 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT... Sample Sites, Collecting Surface Samples, and Analyzing Standard PCB Wipe Samples § 761.253...

  16. 77 FR 75145 - Impact of the Implementation of the Chemical Weapons Convention (CWC) on Commercial Activities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... Bureau of Industry and Security Impact of the Implementation of the Chemical Weapons Convention (CWC) on... implementation of the Chemical Weapons Convention (CWC), through the Chemical Weapons Convention Implementation Act (CWCIA) and the Chemical Weapons Convention Regulations (CWCR), has had on commercial...

  17. 75 FR 69630 - Impact of Implementation of the Chemical Weapons Convention on Commercial Activities Involving...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-15

    ... Bureau of Industry and Security Impact of Implementation of the Chemical Weapons Convention on Commercial... implementation of the Chemical Weapons Convention (CWC), through the Chemical Weapons Convention Implementation Act (CWCIA) and the Chemical Weapons Convention Regulations (CWCR), has had on commercial...

  18. 40 CFR 711.35 - Electronic filing.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... TSCA CHEMICAL DATA REPORTING REQUIREMENTS § 711.35 Electronic filing. (a) You must use e-CDRweb to...) By Web site. Go to the EPA Inventory Update Reporting Internet homepage at http://www.epa.gov/iur and... TSCA-Hotline@epa.gov for a CD-ROM containing the instructions....

  19. 7 CFR 1150.101 - Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ORDERS; MILK), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Dairy Promotion and Research Order Definitions § 1150.101 Act. Act means Title I, Subtitle B, of the Dairy and Tobacco Adjustment Act of...

  20. 7 CFR 1150.101 - Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ORDERS; MILK), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Dairy Promotion and Research Order Definitions § 1150.101 Act. Act means Title I, Subtitle B, of the Dairy and Tobacco Adjustment Act of...

  1. 7 CFR 1150.101 - Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Dairy Promotion and Research Order Definitions § 1150.101 Act. Act means Title I, Subtitle B, of the Dairy and Tobacco Adjustment Act of...

  2. 7 CFR 1150.101 - Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Dairy Promotion and Research Order Definitions § 1150.101 Act. Act means Title I, Subtitle B, of the Dairy and Tobacco Adjustment Act of...

  3. 7 CFR 1150.101 - Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Dairy Promotion and Research Order Definitions § 1150.101 Act. Act means Title I, Subtitle B, of the Dairy and Tobacco Adjustment Act of...

  4. Long-acting muscarinic antagonists.

    PubMed

    Melani, Andrea S

    2015-01-01

    Chronic obstructive pulmonary disease (COPD) is a major cause of death and disability worldwide. Inhaled bronchodilators are the mainstay of COPD pharmacological treatment. Long-acting muscarinic antagonists (LAMAs) are a major class of inhaled bronchodilators. Some LAMA/device systems with different characteristics and dosing schedules are currently approved for maintenance therapy of COPD and a range of other products are being developed. They improve lung function and patient-reported outcomes and reduce acute bronchial exacerbations with good safety. LAMAs are used either alone or associated with long-acting β₂-agonists, eventually in fixed dose combinations. Long-acting β₂-agonist/LAMA combinations assure additional benefits over the individual components alone. The reader will obtain a view of the safety and efficacy of the different LAMA/device systems in COPD patients. PMID:26109098

  5. Enhanced Clean Air Act enforcement

    SciTech Connect

    Faletto, J.S.

    1997-09-01

    The Clean Air Act Amendments of 1990 added new enforcement authorities which will change the way the US Environmental Protection Agency (EPA), the States and environmental groups litigate enforcement actions. EPA, the States and ordinary citizens now have at their disposal an extensive array of enforcement options to deter or penalize those who violate requirements of the Clean Air Act or State Implementation Plans (SIPs). These new enforcement authorities take on even greater significance for major sources covered by the Title V Operating Permit Program.

  6. Advanced Communications Technology Satellite (ACTS)

    NASA Technical Reports Server (NTRS)

    Gedney, Richard T.; Schertler, Ronald J.

    1989-01-01

    The NASA Advanced Communications Technology Satellite (ACTS) was conceived to help maintain U.S. leadership in the world's communications-satellite market. This experimental satellite is expected to be launched by NASA in 1992 and to furnish the technology necessary for establishing very small aperture terminal digital networks which provide on-demand full-mesh connectivity, and 1.544-MBPS services with only a single hop. Utilizing on-board switching and processing, each individual voice or data circuit can be separately routed to any location in the network. This paper provides an overview of the ACTS and discusses the value of the technology for future communications systems.

  7. Self-acting shaft seals

    NASA Technical Reports Server (NTRS)

    Ludwig, L. P.

    1978-01-01

    Self-acting seals are described in detail. The mathematical models for obtaining a seal force balance and the equilibrium operating film thickness are outlined. Particular attention is given to primary ring response (seal vibration) to rotating seat face runout. This response analysis reveals three different vibration models with secondary seal friction being an important parameter. Leakage flow inlet pressure drop and affects of axisymmetric sealing face deformations are discussed. Experimental data on self-acting face seals operating under simulated gas turbine conditions are given. Also a spiral groove seal design operated to 244 m/sec (800 ft/sec) is described.

  8. CHEMICAL SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORS

    PubMed Central

    Swarts, Benjamin M.; Guo, Zhongwu

    2013-01-01

    Many eukaryotic cell-surface proteins and glycoproteins are anchored to the plasma membrane by glycosylphosphatidylinositols (GPIs), a family of glycolipids that are post-translationally attached to proteins at their C-termini. GPIs and GPI-anchored proteins play important roles in many biological and pathological events, such as cell recognition and adhesion, signal transduction, host defense, and acting as receptors for viruses and toxins. Chemical synthesis of structurally defined GPI anchors and GPI derivatives is a necessary step toward understanding the properties and functions of these molecules in biological systems and exploring their potential therapeutic applications. In the first part of this comprehensive article on the chemical synthesis of GPIs, classic syntheses of naturally occurring GPI anchors from protozoan parasites, yeast, and mammals are covered. The second part of the article focuses on recent diversity-oriented strategies for the synthesis of GPI anchors containing unsaturated lipids, “click chemistry” tags, and highly branched and modified structures. PMID:22794184

  9. A procoagulant chemically sulfated mannan.

    PubMed

    Gracher, Ana Helena P; Santana, Aline G; Cipriani, Thales R; Iacomini, Marcello

    2016-01-20

    Disorders of hemostasis can produce innumerous problems. Polysaccharides have been studied both as anticoagulant and as procoagulant agents. A mannan with a main chain of α-(1 → 6)-linked-Manp units, branched at O-2 mainly by side-chains of 2-O-linked-α-Manp units was chemically sulfated, structurally characterized by NMR and GC-MS (methylation, desulfation and methylation with trideuterated iodomethane), and tested in vitro and in vivo on blood coagulation models. Chemical analyses indicate a high degree of substitution on the sulfated polysaccharide. This polymer acted as a procoagulant agent, increasing blood coagulation in normal and hemophilic plasma, activated platelet aggregation and also decreased ex vivo aPTT. Polymers such as the sulfated mannan could be a helpful source of hemostatic agents to prevent hemorrhagic states. PMID:26572344

  10. Chemical Ecology: Chemical Communication in Nature.

    ERIC Educational Resources Information Center

    Wood, William F.

    1983-01-01

    Substances that deliver chemical messages between same/different species are called semiochemicals. Surveyed are three types of semiochemicals (pheromones, allomones, and kairomones), types of organisms involved, and specific chemicals used to carry the various kinds of messages. (JN)

  11. 7 CFR 1216.1 - Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE PEANUT PROMOTION, RESEARCH, AND INFORMATION ORDER Peanut Promotion, Research, and Information Order Definitions § 1216.1 Act. Act means...

  12. 7 CFR 1216.1 - Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE PEANUT PROMOTION, RESEARCH, AND INFORMATION ORDER Peanut Promotion, Research, and Information Order Definitions § 1216.1 Act. Act means...

  13. 7 CFR 1221.1 - Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SORGHUM PROMOTION, RESEARCH, AND INFORMATION ORDER Sorghum Promotion, Research, and Information Order Definitions § 1221.1 Act. Act means...

  14. 7 CFR 1221.1 - Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SORGHUM PROMOTION, RESEARCH, AND INFORMATION ORDER Sorghum Promotion, Research, and Information Order Definitions § 1221.1 Act. Act means...

  15. 7 CFR 1221.1 - Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SORGHUM PROMOTION, RESEARCH, AND INFORMATION ORDER Sorghum Promotion, Research, and Information Order Definitions § 1221.1 Act. Act means...

  16. 7 CFR 1221.1 - Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SORGHUM PROMOTION, RESEARCH, AND INFORMATION ORDER Sorghum Promotion, Research, and Information Order Definitions § 1221.1 Act. Act means...

  17. 7 CFR 1221.1 - Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SORGHUM PROMOTION, RESEARCH, AND INFORMATION ORDER Sorghum Promotion, Research, and Information Order Definitions § 1221.1 Act. Act means...

  18. 7 CFR 1220.600 - Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Procedures To Request a Referendum Definitions § 1220.600 Act. Act means the...

  19. 7 CFR 1220.600 - Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Procedures To Request a Referendum Definitions § 1220.600 Act. Act means the...

  20. 7 CFR 1220.600 - Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Procedures To Request a Referendum Definitions § 1220.600 Act. Act means the...

  1. 7 CFR 1220.600 - Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Procedures To Request a Referendum Definitions § 1220.600 Act. Act means the...

  2. 7 CFR 1218.1 - Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BLUEBERRY PROMOTION, RESEARCH, AND INFORMATION ORDER Blueberry Promotion, Research, and Information Order Definitions § 1218.1 Act. Act means...

  3. 7 CFR 1218.1 - Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BLUEBERRY PROMOTION, RESEARCH, AND INFORMATION ORDER Blueberry Promotion, Research, and Information Order Definitions § 1218.1 Act. Act means...

  4. 7 CFR 1218.1 - Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BLUEBERRY PROMOTION, RESEARCH, AND INFORMATION ORDER Blueberry Promotion, Research, and Information Order Definitions § 1218.1 Act. Act means...

  5. 7 CFR 1218.1 - Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BLUEBERRY PROMOTION, RESEARCH, AND INFORMATION ORDER Blueberry Promotion, Research, and Information Order Definitions § 1218.1 Act. Act means...

  6. 7 CFR 1218.1 - Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BLUEBERRY PROMOTION, RESEARCH, AND INFORMATION ORDER Blueberry Promotion, Research, and Information Order Definitions § 1218.1 Act. Act means...

  7. 7 CFR 1216.1 - Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE PEANUT PROMOTION, RESEARCH, AND INFORMATION ORDER Peanut Promotion, Research, and Information Order Definitions § 1216.1 Act. Act means...

  8. 7 CFR 1216.1 - Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE PEANUT PROMOTION, RESEARCH, AND INFORMATION ORDER Peanut Promotion, Research, and Information Order Definitions § 1216.1 Act. Act means...

  9. 7 CFR 1216.1 - Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE PEANUT PROMOTION, RESEARCH, AND INFORMATION ORDER Peanut Promotion, Research, and Information Order Definitions § 1216.1 Act. Act means...

  10. 7 CFR 65.100 - Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) COUNTRY OF ORIGIN LABELING OF BEEF, PORK, LAMB, CHICKEN, GOAT MEAT, PERISHABLE AGRICULTURAL COMMODITIES, MACADAMIA NUTS, PECANS,...

  11. 7 CFR 1207.302 - Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan Definitions § 1207.302 Act. Act means the Potato Research...

  12. 7 CFR 1207.302 - Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan Definitions § 1207.302 Act. Act means the Potato Research...

  13. 7 CFR 1207.302 - Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan Definitions § 1207.302 Act. Act means the Potato Research...

  14. 7 CFR 1207.302 - Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan Definitions § 1207.302 Act. Act means the Potato Research...

  15. 7 CFR 1207.302 - Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan Definitions § 1207.302 Act. Act means the Potato Research...

  16. 7 CFR 1206.1 - Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE MANGO PROMOTION, RESEARCH, AND INFORMATION Mango Promotion, Research, and Information Order Definitions § 1206.1 Act. Act means the...

  17. 7 CFR 1206.1 - Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE MANGO PROMOTION, RESEARCH, AND INFORMATION Mango Promotion, Research, and Information Order Definitions § 1206.1 Act. Act means the...

  18. 7 CFR 1206.1 - Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE MANGO PROMOTION, RESEARCH, AND INFORMATION Mango Promotion, Research, and Information Order Definitions § 1206.1 Act. Act means the...

  19. 7 CFR 1206.1 - Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE MANGO PROMOTION, RESEARCH, AND INFORMATION Mango Promotion, Research, and Information Order Definitions § 1206.1 Act. Act means the...

  20. 7 CFR 1206.1 - Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE MANGO PROMOTION, RESEARCH, AND INFORMATION Mango Promotion, Research, and Information Order Definitions § 1206.1 Act. Act means the...

  1. The Chemical Engineer in the Chemical Industry.

    ERIC Educational Resources Information Center

    Zabicky, Jacob

    1986-01-01

    Describes a course for third- or fourth-year chemical engineering students designed to acquaint them with the chemical industry. The course deals with productivity, characteristics of the chemical industry, sources of information, industrial intelligence, research and development, patent law, technology transfer, and quality control. (TW)

  2. 78 FR 16692 - Chemical Facility Anti-Terrorism Standards (CFATS)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-18

    ..., Chemical Facility Anti-Terrorism Standards (CFATS) for an additional 30 days. \\1\\ See 77 FR 74677. The 60... mandate at 72 FR 17688. Section 550 of the Homeland Security Appropriations Act of 2007 requires a risk... SECURITY Chemical Facility Anti-Terrorism Standards (CFATS) AGENCY: National Protection and...

  3. 13 CFR 107.115 - 1940 Act and 1980 Act Companies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false 1940 Act and 1980 Act Companies... INVESTMENT COMPANIES Qualifying for an SBIC License Organizing An Sbic § 107.115 1940 Act and 1980 Act Companies. A 1940 Act or 1980 Act Company is eligible to apply for an SBIC license, and an existing...

  4. ACT and General Cognitive Ability

    ERIC Educational Resources Information Center

    Koenig, Katherine A.; Frey, Meredith C.; Detterman, Douglas K.

    2008-01-01

    Research on the SAT has shown a substantial correlation with measures of "g" such as the Armed Services Vocational Aptitude Battery (ASVAB). Another widely administered test for college admission is the American College Test (ACT). Using the National Longitudinal Survey of Youth 1979, measures of "g" were derived from the ASVAB and correlated with…

  5. 78 FR 46256 - Privacy Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-31

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ELECTION COMMISSION 11 CFR Part 1 Privacy Act CFR Correction In Title 11 of the Code of Federal Regulations, revised as of January 1, 2012, on page 5, in Sec. 1.2, the words ``95 and 96 of the Internal Revenue Code...

  6. Clean Water Act amendments debated

    SciTech Connect

    Deland, M.R.

    1982-08-01

    A short discussion of the debate taking place between Congress, industry and environmental groups with respect to the amendments to the Clean Water Act is presented. The discussion considers the EPA proposal, the reaction to it, and the prognosis for passage. (KRM)

  7. The Indian Child Welfare Act.

    ERIC Educational Resources Information Center

    Steward, Katy Jo

    The Indian Child Welfare Act of 1978 (I.C.W.A.) is federal legislation which preempts state law whenever Indian children may be removed from their families. The I.C.W.A. permits Indian tribal courts to decide the future of Indian children, establishes minimum federal standards for removal of Indian children from their families, requires that…

  8. Clery Act: Road to Compliance

    ERIC Educational Resources Information Center

    McNeal, Laura R.

    2007-01-01

    The purpose of this study was to explore what factors served as impediments to institutional efforts to comply with Clery Act guidelines through the perceptions of campus law administrators. Statistical analyses were performed on data collected from an online survey, which was distributed to members of the International Association of Campus Law…

  9. FDA Food Safety Modernization Act

    THOMAS, 111th Congress

    Rep. Sutton, Betty [D-OH-13

    2009-06-08

    01/04/2011 Became Public Law No: 111-353. (TXT | PDF) (All Actions) Notes: H.R.2751 was introduced and first passed the House as the Consumer Assistance to Recycle and Save Act. Tracker: This bill has the status Became LawHere are the steps for Status of Legislation:

  10. Chemical Stockpile Disposal Program

    SciTech Connect

    Krummel, J.R.; Policastro, A.J.; Olshansky, S.J.; McGinnis, L.D.

    1990-10-01

    As part of the Chemical Stockpile Disposal Program mandated by Public Law 99--145 (Department of Defense Authorization Act), an independent review is presented of the US Army Phase I environmental report for the disposal program at the Pine Bluff Arsenal (PBA) in Arkansas. The Phase I report addressed new and additional concerns not incorporated in the final programmatic environmental impact statement (FPEIS). Those concerns were addressed by examining site-specific data for the PBA and by recommending the scope and content of a more detailed site- specific study. This dependent review evaluates whether the new site-specific data presented in the Phase I report would alter the decision in favor of on-site disposal that was reached in the FPEIS, and whether the recommendations for the scope and content of the site-specific study are adequate. Based on the methods and assumptions presented in the FPEIS, the inclusion of more detailed site-specific data in the Phase I report does not change the decision reached in the FPEIS (which favored on-site disposal at PBA). It is recommended that alternative assumptions about meteorological conditions be considered and that site-specific data on water, ecological, socioeconomic, and cultural resources, and emergency planning and preparedness be considered explicitly in the site-specific EIS decision-making process. 13 refs., 1 fig.

  11. Chemical Stockpile Disposal Program

    SciTech Connect

    Krummel, J.R.; Policastro, A.J.; Olshansky, S.J.; McGinnis, L.D.

    1990-10-01

    As part of the Chemical Stockpile Disposal Program mandated by Public Law 99--145 (Department of Defense Authorization Act), an independent review is presented of the US Army Phase I environmental report for the disposal program at the Umatilla Depot Activity (UMDA) in Hermiston, Oregon. The Phase I report addressed new and additional concerns not incorporated in the final programmatic environmental impact statement (FPEIS). Those concerns were addressed by examining site-specific data for the Umatilla Depot Activity and by recommending the scope and content of a more detailed site-specific study. This independent review evaluates whether the new site-specific data presented in the Phase I report would alter the decision in favor of on-site disposal that was reached in the FPEIS, and whether the recommendations for the scope and content of the site-specific study are adequate. Based on the methods and assumptions presented in the FPEIS, the inclusion of more detailed site-specific data in the Phase I report does not change the decision reached in the FPEIS (which favored on-site disposal at UMDA). It is recommended that alternative assumptions about meteorological conditions be considered and that site-specific data on water, ecological, socioeconomic, and cultural resources; seismicity; and emergency planning and preparedness be considered explicitly in the site-specific EIS decision-making process. 7 refs., 1 fig.

  12. 76 FR 68809 - Bureau of International Security and Nonproliferation; Termination of Chemical and Biological...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ... Control Act and Section 11C(a) and (c) of the Export Administration Act. (Volume 59 FR Public Notice 2143... of International Security and Nonproliferation; Termination of Chemical and Biological Weapons (CBW... chemical or biological weapons capability: Gerhard Merz This determination and certification terminates...

  13. Microfluidic chemical reaction circuits

    DOEpatents

    Lee, Chung-cheng; Sui, Guodong; Elizarov, Arkadij; Kolb, Hartmuth C.; Huang, Jiang; Heath, James R.; Phelps, Michael E.; Quake, Stephen R.; Tseng, Hsian-rong; Wyatt, Paul; Daridon, Antoine

    2012-06-26

    New microfluidic devices, useful for carrying out chemical reactions, are provided. The devices are adapted for on-chip solvent exchange, chemical processes requiring multiple chemical reactions, and rapid concentration of reagents.

  14. Compensation for occupational diseases by chemical agents in Korea.

    PubMed

    Kwon, Soon-Chan; Roh, Soo-Yong; Lee, Ji-Hoon; Kim, Eun-A

    2014-06-01

    Investigation into the frequency of compensation for occupational diseases (ODs) caused by hazardous chemicals revealed an important opportunity for the improvement and further development of occupational health and safety systems in Korea. In response to concerns after outbreaks of disease due to chemical exposure, specific criteria for recognition of ODs were established and included in the Enforcement Decree of the Labor Standard Act (LSA) and the Industrial Accident Compensation Insurance Act (IACIA) on June 28, 2013. However, the original versions of the LSA and IACIA contain several limitations. First, the criteria was listed inconsistently according to the symptoms or signs of acute poisoning. Second, all newly recognized hazardous chemicals and chemicals recognized as hazardous by the International Labor Organization (ILO) were not included in the LSA and IACIA. Although recent amendments have addressed these shortcomings, future amendments should strive to include all chemicals listed by the ILO and continuously add newly discovered hazardous chemicals as they are introduced into the workplace. PMID:25006329

  15. Compensation for occupational diseases by chemical agents in Korea.

    PubMed

    Kwon, Soon-Chan; Roh, Soo-Yong; Lee, Ji-Hoon; Kim, Eun-A

    2014-06-01

    Investigation into the frequency of compensation for occupational diseases (ODs) caused by hazardous chemicals revealed an important opportunity for the improvement and further development of occupational health and safety systems in Korea. In response to concerns after outbreaks of disease due to chemical exposure, specific criteria for recognition of ODs were established and included in the Enforcement Decree of the Labor Standard Act (LSA) and the Industrial Accident Compensation Insurance Act (IACIA) on June 28, 2013. However, the original versions of the LSA and IACIA contain several limitations. First, the criteria was listed inconsistently according to the symptoms or signs of acute poisoning. Second, all newly recognized hazardous chemicals and chemicals recognized as hazardous by the International Labor Organization (ILO) were not included in the LSA and IACIA. Although recent amendments have addressed these shortcomings, future amendments should strive to include all chemicals listed by the ILO and continuously add newly discovered hazardous chemicals as they are introduced into the workplace.

  16. Chemical Management System

    1998-10-30

    CMS provides an inventory of all chemicals on order or being held in the laboratory, to provide a specific location for all chemical containers, to ensure that health and safety regulatory codes are being upheld, and to provide PNNL staff with hazardous chemical information to better manage their inventories. CMS is comprised of five major modules: 1) chemical purchasing, 2) chemical inventory, 3) chemical names, properties, and hazard groups, 4) reporting, and 5) system administration.

  17. Nature's chemicals and synthetic chemicals: Comparative toxicology

    SciTech Connect

    Ames, B.N.; Profet, M.; Gold, L.S. )

    1990-10-01

    The toxicology of synthetic chemicals is compared to that of natural chemicals, which represent the vast bulk of the chemicals to which humans are exposed. It is argued that animals have a broad array of inducible general defenses to combat the changing array of toxic chemicals in plant food (nature's pesticides) and that these defenses are effective against both natural and synthetic toxins. Synthetic toxins such as dioxin are compared to natural chemicals, such as indole carbinol (in broccoli) and ethanol. Trade-offs between synthetic and natural pesticides are discussed. The finding that in high-dose tests, a high proportion of both natural and synthetic chemicals are carcinogens, mutagens, teratogens, and clastogens (30-50{percent} for each group) undermines current regulatory efforts to protect public health from synthetic chemicals based on these tests.

  18. Nature's chemicals and synthetic chemicals: comparative toxicology.

    PubMed Central

    Ames, B N; Profet, M; Gold, L S

    1990-01-01

    The toxicology of synthetic chemicals is compared to that of natural chemicals, which represent the vast bulk of the chemicals to which humans are exposed. It is argued that animals have a broad array of inducible general defenses to combat the changing array of toxic chemicals in plant food (nature's pesticides) and that these defenses are effective against both natural and synthetic toxins. Synthetic toxins such as dioxin are compared to natural chemicals, such as indole carbinol (in broccoli) and ethanol. Trade-offs between synthetic and natural pesticides are discussed. The finding that in high-dose tests, a high proportion of both natural and synthetic chemicals are carcinogens, mutagens, teratogens, and clastogens (30-50% for each group) undermines current regulatory efforts to protect public health from synthetic chemicals based on these tests. PMID:2217211

  19. 40 CFR 799.18 - Chemicals subject of test rules or consent orders for which the testing reimbursement period has...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... action under TSCA section 5, 6, or 7 (in addition to final actions under section 4); see 40 CFR part 707... 80-05-7 Bisphenol A 51 FR 33047, 9/18/86 April 6, 1993 84-65-1 Anthraquinone 52 FR 21018, 6/4/87...

  20. 40 CFR 799.18 - Chemicals subject of test rules or consent orders for which the testing reimbursement period has...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... action under TSCA section 5, 6, or 7 (in addition to final actions under section 4); see 40 CFR part 707... 80-05-7 Bisphenol A 51 FR 33047, 9/18/86 April 6, 1993 84-65-1 Anthraquinone 52 FR 21018, 6/4/87...

  1. 40 CFR 799.18 - Chemicals subject of test rules or consent orders for which the testing reimbursement period has...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... action under TSCA section 5, 6, or 7 (in addition to final actions under section 4); see 40 CFR part 707... 80-05-7 Bisphenol A 51 FR 33047, 9/18/86 April 6, 1993 84-65-1 Anthraquinone 52 FR 21018, 6/4/87...

  2. 40 CFR 799.18 - Chemicals subject of test rules or consent orders for which the testing reimbursement period has...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... action under TSCA section 5, 6, or 7 (in addition to final actions under section 4); see 40 CFR part 707...-Dichloropropane 52 FR 37138, 10/5/87 April 17, 1995 79-94-7 Tetrabromobisphenol-A 52 FR 25219, 7/6/87 Aug 24,...

  3. 40 CFR 799.18 - Chemicals subject of test rules or consent orders for which the testing reimbursement period has...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... action under TSCA section 5, 6, or 7 (in addition to final actions under section 4); see 40 CFR part 707...-Dichloropropane 52 FR 37138, 10/5/87 April 17, 1995 79-94-7 Tetrabromobisphenol-A 52 FR 25219, 7/6/87 Aug 24,...

  4. Chemical Industry Corrosion Management

    SciTech Connect

    2003-02-01

    Improved Corrosion Management Could Provide Significant Cost and Energy Savings for the Chemical Industry. In the chemical industry, corrosion is often responsible for significant shutdown and maintenance costs.

  5. 34 CFR 300.4 - Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Definitions Used in This Part § 300.4 Act. Act means the Individuals with Disabilities Education Act, as... 34 Education 2 2010-07-01 2010-07-01 false Act. 300.4 Section 300.4 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE...

  6. 7 CFR 35.1 - Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS EXPORT GRAPES AND PLUMS Definitions § 35.1 Act. Act or Export Grape and Plum Act means “An Act to promote the foreign trade of the United States in grapes and plums, to protect the reputation of American-grown grapes and plums...

  7. 7 CFR 35.1 - Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS EXPORT GRAPES AND PLUMS Definitions § 35.1 Act. Act or Export Grape and Plum Act means “An Act to promote the foreign trade of the United States in grapes and plums, to protect the reputation of American-grown grapes and plums...

  8. 7 CFR 35.1 - Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS EXPORT GRAPES AND PLUMS Definitions § 35.1 Act. Act or Export Grape and Plum Act means “An Act to promote the foreign trade of the United States in grapes and plums, to protect the reputation of American-grown grapes and plums...

  9. 7 CFR 35.1 - Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS EXPORT GRAPES AND PLUMS Definitions § 35.1 Act. Act or Export Grape and Plum Act means “An Act to promote the foreign trade of the United States in grapes and plums, to protect the reputation of American-grown grapes and plums...

  10. 7 CFR 35.1 - Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS EXPORT GRAPES AND PLUMS Definitions § 35.1 Act. Act or Export Grape and Plum Act means “An Act to promote the foreign trade of the United States in grapes and plums, to protect the reputation of American-grown grapes and plums...

  11. 7 CFR 1205.10 - Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... for Conduct of Sign-up Period Definitions § 1205.10 Act. The term Act means the Cotton Research and Promotion Act, as amended . ... 7 Agriculture 10 2014-01-01 2014-01-01 false Act. 1205.10 Section 1205.10 Agriculture...

  12. 7 CFR 1205.10 - Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... for Conduct of Sign-up Period Definitions § 1205.10 Act. The term Act means the Cotton Research and Promotion Act, as amended . ... 7 Agriculture 10 2011-01-01 2011-01-01 false Act. 1205.10 Section 1205.10 Agriculture...

  13. 40 CFR 791.105 - Prohibited acts.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 33 2013-07-01 2013-07-01 false Prohibited acts. 791.105 Section 791.105 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) DATA REIMBURSEMENT Prohibited Acts § 791.105 Prohibited acts. Failure to provide...

  14. 40 CFR 791.105 - Prohibited acts.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 33 2012-07-01 2012-07-01 false Prohibited acts. 791.105 Section 791.105 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) DATA REIMBURSEMENT Prohibited Acts § 791.105 Prohibited acts. Failure to provide...

  15. 40 CFR 791.105 - Prohibited acts.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 31 2010-07-01 2010-07-01 true Prohibited acts. 791.105 Section 791.105 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) DATA REIMBURSEMENT Prohibited Acts § 791.105 Prohibited acts. Failure to provide...

  16. Acting Out; Theoretical and Clinical Aspects.

    ERIC Educational Resources Information Center

    Abt, Lawrence Edwin, Ed.; Weissman, Stuart L.

    The beneficial and harmful effects of acting out are studied in a series of short essays by numerous authors. Included are four articles on the theoretical and dynamic considerations of acting out, along with five clinical manifestations of acting out involving suicide and criminality in adolescents and adults. Special forms of harmful acting out…

  17. 76 FR 25665 - No Fear Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-05

    ... COMMISSION No Fear Act AGENCY: American Battle Monuments Commission. ACTION: Notice. SUMMARY: The American... FEAR Act), as implemented by the Office of Personnel Management (OPM) regulations at 5 CFR part 724... Retaliation Act of 2002,'' which is now known as the No FEAR Act. See Public Law 107-174, codified at 5...

  18. Advanced Communications Technology Satellite (ACTS)

    NASA Technical Reports Server (NTRS)

    Plecity, Mark S.; Nall, Mark E.

    1991-01-01

    The NASA Advanced Communications Technology Satellite (ACTS) provides high risk technologies having the potential to dramatically enhance the capabilities of the satellite communications industry. This experimental satellite, which will be launched by NASA in 1993, will furnish the technology necessary for providing a range of services. Utilizing the ACTS very-high-gain-hopping spot-beam antennas with on-board routing and processing, Very Small Aperture Terminal (VSAT) digital networks which provide on-demand, full-mesh-convectivity 1.544-MBPS services with only a single hop can be established. The high-gain spot-beam antenna at Ka-band permits wide area, flexible networks providing high data rate services between modest-size earth terminals.

  19. Self-acting shaft seals

    NASA Technical Reports Server (NTRS)

    Ludwig, L. P.

    1978-01-01

    Self-acting seals are described in detail. The mathematical models for obtaining a seal force balance and the equilibrium operating film thickness are outlined. Particular attention is given to primary ring response (seal vibration) to rotating seat face runout. This response analysis reveals three different vibration modes, with secondary seal friction being an important parameter. Leakage flow inlet pressure drop and effects of axisymmetric and nonaxisymmetric sealing face deformations are discussed. Experimental data on self-acting face seals operating under simulated gas turbine conditions are given; these data show the feasibility of operating the seal at conditions of 345 N/sq cm and 152 m/sec sliding speed. Also a spiral groove seal design operated to 244 m/sec is described.

  20. Long-acting hormonal contraception.

    PubMed

    Benagiano, Giuseppe; Gabelnick, Henry; Brosens, Ivo

    2015-11-01

    Today, a new category of fertility-regulating agents has been created: long-acting, reversible hormonal contraceptives; they minimize compliance, while maximize effectiveness. They comprise subdermal implants and intrauterine devices. Other long-acting agents exist, such as Depo Provera and Noristerat. Use of Depo Provera and Noristerat carries great effectiveness, good clinical safety and usefulness in developing countries. They cause no significant increase in breast cancer risk, but they may carry an increased risk of HIV. Subcutaneous delivery systems have two common features: prolongation of effect is obtained by a drug reservoir and for most of their duration of action they provide a continuous, sustained release of the active hormone. Finally, the intrauterine system Mirena represents both a very effective contraceptive and a specific treatment for menorrhagia.

  1. The False Claims Act and clinical laboratories.

    PubMed

    Vogel, R L

    1993-01-01

    In its efforts to fight fraud, the government has turned increasingly to the civil False Claims Act. The Act imposes triple damages plus monetary penalties against those who defraud the federal government. The Act also encourages whistleblowers to report fraud by offering the prospect of large bounties. This article describes the False Claims Act, its qui tam provision dealing with whistleblowers, and the application of the Act to clinical laboratories.

  2. SCADA Application for ACTS Technology

    NASA Technical Reports Server (NTRS)

    Fairbanks, Barry

    1992-01-01

    The results of a system level study done by Hughes Network Systems for NASA are presented. For the supervisory control and data acquisition (SCADA) application, use of Ka-band spot beam satellite technology associated with NASA's Advanced Communication Technology Satellite (ACTS) offers a reduction in Earth station antenna size and transmitter power that may translate into lower system costs. The approaches taken to determine commercial potential of the system are described.

  3. Elder Justice Act of 2009

    THOMAS, 111th Congress

    Rep. Rangel, Charles B. [D-NY-15

    2009-09-17

    03/23/2010 Became Public Law No: 111-148. (TXT | PDF) (All Actions) Notes: H.R.4872 makes a number of health-related financing and revenue changes to this bill. Read together, this bill and the health care-related provisions of H.R.4872 are commonly referred to as the Affordable Care Act (ACA). Tracker: This bill has the status Became LawHere are the steps for Status of Legislation:

  4. Clean Air Act. Revision 5

    SciTech Connect

    Not Available

    1994-02-15

    This Reference Book contains a current copy of the Clean Air Act, as amended, and those regulations that implement the statute and appear to be most relevant to DOE activities. The document is provided to DOE and contractor staff for informational purposes only and should not be interpreted as legal guidance. This Reference Book has been completely revised and is current through February 15, 1994.

  5. Environmental and chemical carcinogenesis.

    PubMed

    Wogan, Gerald N; Hecht, Stephen S; Felton, James S; Conney, Allan H; Loeb, Lawrence A

    2004-12-01

    . This approach can be applied to evaluation of other environmental carcinogens, and the evaluations would be markedly facilitated by prospective epidemiologic studies incorporating phenotypic carcinogen-specific biomarkers. Heterocyclic amines represent an important class of carcinogens in foods. They are mutagens and carcinogens at numerous organ sites in experimental animals, are produced when meats are heated above 180 degrees C for long periods. Four of these compounds can consistently be identified in well-done meat products from the North American diet, and although a causal linkage has not been established, a majority of epidemiology studies have linked consumption of well-done meat products to cancer of the colon, breast and stomach. Studies employing molecular biomarkers suggest that individuals may differ in their susceptibility to these carcinogens, and genetic polymorphisms may contribute to this variability. Heterocyclic amines, like most other chemical carcinogens, are not carcinogenic per se but must be metabolized by a family of cytochrome P450 enzymes to chemically reactive electrophiles prior to reacting with DNA to initiate a carcinogenic response. These same cytochrome P450 enzymes--as well as enzymes that act on the metabolic products of the cytochromes P450 (e.g. glucuronyl transferase, glutathione S-transferase and others)--also metabolize chemicals by inactivation pathways, and the relative amounts of activation and detoxification will determine whether a chemical is carcinogenic. Because both genetic and environmental factors influence the levels of enzymes that metabolically activate and detoxify chemicals, they can also influence carcinogenic risk. Many of the phenotypes of cancer cells can be the result of mutations, i.e., changes in the nucleotide sequence of DNA that accumulate as tumors progress. These can arise as a result of DNA damage or by the incorporation of non-complementary nucleotides during DNA synthetic processes. Based upon the

  6. Nitric oxide: a synchronizing chemical messenger.

    PubMed

    Anbar, M

    1995-06-14

    Nitric oxide (NO) has been recognized as a ubiquitous chemical messenger in a large number of different biological systems. Its chemical properties make it less specific and less controllable than practically any other neurotransmitter or hormone. In view of this, its extensive biological role as a chemical messenger seems surprising. It is suggested that the biological function of NO evolved early in the anaerobic stage of evolution. In view of its low molecular weight, limited interaction with water, and its electrical neutrality, which allow it to diffuse rapidly through the cytoplasm and biomembranes, it is suggested that the need for NO has been retained by and maintained in eukaryote cells because of its ability to affect many biochemical functions simultaneously, acting primarily as an intracellular synchronizing chemical messenger.

  7. The chemical life(1).

    PubMed

    Hodges, Nathan

    2015-01-01

    You write this narrative autoethnography to open up a conversation about our chemical lives. You go through your day with chemical mindfulness, questioning taken-for-granted ideas about natural and artificial, healthy and unhealthy, dependency and addiction, trying to understand the chemical messages we consume through the experiences of everyday life. You reflect on how messages about chemicals influence and structure our lives and why some chemicals are celebrated and some are condemned. Using a second-person narrative voice, you show how the personal is relational and the chemical is cultural. You write because you seek a connection, a chemical bond. PMID:24905820

  8. The chemical life(1).

    PubMed

    Hodges, Nathan

    2015-01-01

    You write this narrative autoethnography to open up a conversation about our chemical lives. You go through your day with chemical mindfulness, questioning taken-for-granted ideas about natural and artificial, healthy and unhealthy, dependency and addiction, trying to understand the chemical messages we consume through the experiences of everyday life. You reflect on how messages about chemicals influence and structure our lives and why some chemicals are celebrated and some are condemned. Using a second-person narrative voice, you show how the personal is relational and the chemical is cultural. You write because you seek a connection, a chemical bond.

  9. PINS chemical identification software

    DOEpatents

    Caffrey, Augustine J.; Krebs, Kennth M.

    2004-09-14

    An apparatus and method for identifying a chemical compound. A neutron source delivers neutrons into the chemical compound. The nuclei of chemical elements constituting the chemical compound emit gamma rays upon interaction with the neutrons. The gamma rays are characteristic of the chemical elements constituting the chemical compound. A spectrum of the gamma rays is generated having a detection count and an energy scale. The energy scale is calibrated by comparing peaks in the spectrum to energies of pre-selected chemical elements in the spectrum. A least-squares fit completes the calibration. The chemical elements constituting the chemical compound can be readily determined, which then allows for identification of the chemical compound.

  10. Powerful Partners: Arabidopsis and Chemical Genomics

    PubMed Central

    Robert, Stéphanie; Raikhel, Natasha V.; Hicks, Glenn R.

    2009-01-01

    Chemical genomics (i.e. genomics scale chemical genetics) approaches capitalize on the ability of low molecular mass molecules to modify biological processes. Such molecules are used to modify the activity of a protein or a pathway in a manner that it is tunable and reversible. Bioactive chemicals resulting from forward or reverse chemical screens can be useful in understanding and dissecting complex biological processes due to the essentially limitless variation in structure and activities inherent in chemical space. A major advantage of this approach as a powerful addition to conventional plant genetics is the fact that chemical genomics can address loss-of-function lethality and redundancy. Furthermore, the ability of chemicals to be added at will and to act quickly can permit the study of processes that are highly dynamic such as endomembrane trafficking. An important aspect of utilizing small molecules effectively is to characterize bioactive chemicals in detail including an understanding of structure-activity relationships and the identification of active and inactive analogs. Bioactive chemicals can be useful as reagents to probe biological pathways directly. However, the identification of cognate targets and their pathways is also informative and can be achieved by screens for genetic resistance or hypersensitivity in Arabidopsis thaliana or other organisms from which the results can be translated to plants. In addition, there are approaches utilizing “tagged” chemical libraries that possess reactive moieties permitting the immobilization of active compounds. This opens the possibility for biochemical purification of putative cognate targets. We will review approaches to screen for bioactive chemicals that affect biological processes in Arabidopsis and provide several examples of the power and challenges inherent in this new approach in plant biology. PMID:22303245

  11. Chemical contamination and the thyroid.

    PubMed

    Duntas, Leonidas H

    2015-02-01

    Industrial chemical contaminants have a variable impact on the hypothalamic-pituitary-thyroid axis, this depending both on their class and on confounding factors. Today, mounting evidence is pointing to the role of environmental factors, and specifically EDCs, in the current distressing upsurge in the incidence of thyroid disease. The unease is warranted. These substances, which are nowadays rife in our environments (including in foodstuffs), have been shown to interfere with thyroid hormone action, biosynthesis, and metabolism, resulting in disruption of tissue homeostasis and/or thyroid function. Importantly, based on the concept of the "nonmonotonic dose-response curve", the relationship between dose and effect has often been found to be nonlinear. Thus, small doses can induce unpredictable, adverse effects, one case being polychlorinated biphenyls (PCBs), of which congener(s) may centrally inhibit the hypothalamic-pituitary-thyroid axis, or dissociate thyroid receptor and selectively affect thyroid hormone signaling and action. This means that PCBs can act as agonists or antagonists at the receptor level, underlining the complexity of the interaction. This review highlights the multifold activity of chemicals demonstrated to cause thyroid disruption. It also represents a call to action among clinicians to undertake systematic monitoring of thyroid function and registering of the classes of EDs and additionally urges broader scientific collaborations to clarify these chemicals' molecular mechanisms of action, substances whose prevalence in our environments is disrupting not only the thyroid but all life on earth. PMID:25294013

  12. Chemical scissors cut phosphorene nanostructures

    NASA Astrophysics Data System (ADS)

    Peng, Xihong; Wei, Qun

    2014-12-01

    Phosphorene, a recently fabricated two-dimensional puckered honeycomb structure of phosphorus, showed promising properties for applications in nano-electronics. In this work, we report a chemical scissors effect on phosphorene, using first-principles method. It was found that chemical species, such as H, OH, F, and Cl, can act as scissors to cut phosphorene. Phosphorus nanochains and nanoribbons can be obtained. The scissors effect results from the strong bonding between the chemical species and phosphorus atoms. Other species such as O, S and Se fail to cut phosphorene nanostructures due to their weak bonding with phosphorus. The electronic structures of the produced P-chains reveal that the hydrogenated chain is an insulator while the pristine chain is a one-dimensional Dirac material, in which the charge carriers are massless fermions travelling at an effective speed of light ˜8 × 105 m s-1. The obtained zigzag phosphorene nanoribbons show either metallic or semiconducting behaviors, depending on the treatment of the edge phosphorus atoms.

  13. [Food Sanitation Act and Minamata Disease].

    PubMed

    Ishihara, Nobuo

    2016-01-01

    Immediately after the official recognition of Minamata disease (1956.5.l) a study group at Kumamoto University suggested that Minamata disease was caused by food poisoning. The next year, this suggestion was accepted by the Ministry of Health and Welfare (MHW). Prior to the decision to apply the Food Sanitation Act (FSA), the local government asked MHW for the application of FSA. Soon after, the chief of the Public Health Bureau replied to the local government that the application of FSA to the Minamata area was impossible. Epidemiological investigations of residents and polluted areas, therefore, were not carried out. Data essential for the screening for exposed residents were unavailable. The criteria for the screening were presented. The Environmental Agency (EA) presented the criteria in the form of notice in 1971, which were revised in 1977. Notwithstanding the clear difference between the original and revised criteria, EA insisted that these two sets of criteria were quite similar. This insistence by EA and the absence of epidemiological data on residents and polluted area resulted in the present confusion about Minamata disease. The application of FSA was stopped by bureaucrats who had no interest in the environmental problems and by several scientists patronized by stakeholders (Chisso, Japanese Association of Chemical Industries, MHW and EA). Stakeholders suppressed science.

  14. [Food Sanitation Act and Minamata Disease].

    PubMed

    Ishihara, Nobuo

    2016-01-01

    Immediately after the official recognition of Minamata disease (1956.5.l) a study group at Kumamoto University suggested that Minamata disease was caused by food poisoning. The next year, this suggestion was accepted by the Ministry of Health and Welfare (MHW). Prior to the decision to apply the Food Sanitation Act (FSA), the local government asked MHW for the application of FSA. Soon after, the chief of the Public Health Bureau replied to the local government that the application of FSA to the Minamata area was impossible. Epidemiological investigations of residents and polluted areas, therefore, were not carried out. Data essential for the screening for exposed residents were unavailable. The criteria for the screening were presented. The Environmental Agency (EA) presented the criteria in the form of notice in 1971, which were revised in 1977. Notwithstanding the clear difference between the original and revised criteria, EA insisted that these two sets of criteria were quite similar. This insistence by EA and the absence of epidemiological data on residents and polluted area resulted in the present confusion about Minamata disease. The application of FSA was stopped by bureaucrats who had no interest in the environmental problems and by several scientists patronized by stakeholders (Chisso, Japanese Association of Chemical Industries, MHW and EA). Stakeholders suppressed science. PMID:26832624

  15. Fast-acting valve actuator

    DOEpatents

    Cho, Nakwon

    1980-01-01

    A fast-acting valve actuator utilizes a spring driven pneumatically loaded piston to drive a valve gate. Rapid exhaust of pressurized gas from the pneumatically loaded side of the piston facilitates an extremely rapid piston stroke. A flexible selector diaphragm opens and closes an exhaust port in response to pressure differentials created by energizing and de-energizing a solenoid which controls the pneumatic input to the actuator as well as selectively providing a venting action to one side of the selector diaphragm.

  16. Analysis of the impact of the regulation of toxic substances on Sandia

    SciTech Connect

    Arnold, C. Jr.; Pigg, J.

    1980-10-01

    In recent years, Congress has passed two regulatory acts, namely the Occupational Safety and Health Act (OSHA) and the Toxic Substance Control Act (TSCA) which seek to control the manufacture, use, and disposal of hazardous chemical substances. These acts can have a significant impact on Sandia's missions and will particularly affect those organizations involved in materials development and selection. The primary purpose of this report is to describe in some detail the impact of these acts on Sandia's corporate goals and make recommendations on what our response should be. Also described in this report is the present position of Sandia with respect to these regulatory acts and the policies and actions that Sandia has taken to date in an effort to minimize their impact.

  17. Additive effects on the androgen signaling pathway by chemicals with different modes of action-COW2015

    EPA Science Inventory

    Risk assessments have traditionally been developed on a chemical-by-chemical basis. However, regulatory agencies recently have been considering cumulative effects of chemicals that act via a common mechanism of toxicity. Here we present data on several mixture studies of chemic...

  18. 78 FR 74218 - Imposition of Additional Sanctions on Syria Under the Chemical and Biological Weapons Control and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-10

    ... Imposition of Additional Sanctions on Syria Under the Chemical and Biological Weapons Control and Warfare... chemical weapons in violation of international law or lethal chemical weapons against its own nationals... the Chemical and Biological Weapons Control and Warfare Elimination Act of 1991, 22 U.S.C. 5604(a)...

  19. 75 FR 62569 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-DVD Copy Control...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-12

    ... pursuant to Section 6(b) of the Act on August 3, 2001 (66 FR 40727). The last notification was filed with...) of the Act on July 14, 2010 (75 FR 40851). Patricia A. Brink, Deputy Director of Operations... Kong-China; Mitsubishi Chemical Corporation, Tokyo, Japan; Quantum Optical Laboratories...

  20. ACTS Satellite Telemammography Network Experiments

    NASA Technical Reports Server (NTRS)

    Kachmar, Brian A.; Kerczewski, Robert J.

    2000-01-01

    The Satellite Networks and Architectures Branch of NASA's Glenn Research Center has developed and demonstrated several advanced satellite communications technologies through the Advanced Communications Technology Satellite (ACTS) program. One of these technologies is the implementation of a Satellite Telemammography Network (STN) encompassing NASA Glenn, the Cleveland Clinic Foundation. the University of Virginia, and the Ashtabula County Medical Center. This paper will present a look at the STN from its beginnings to the impact it may have on future telemedicine applications. Results obtained using the experimental ACTS satellite demonstrate the feasibility of Satellite Telemammography. These results have improved teleradiology processes and mammography image manipulation, and enabled advances in remote screening methodologies. Future implementation of satellite telemammography using next generation commercial satellite networks will be explored. In addition, the technical aspects of the project will be discussed, in particular how the project has evolved from using NASA developed hardware and software to commercial off the shelf (COTS) products. Development of asymmetrical link technologies was an outcome of this work. Improvements in the display of digital mammographic images, better understanding of end-to-end system requirements, and advances in radiological image compression were achieved as a result of the research. Finally, rigorous clinical medical studies are required for new technologies such as digital satellite telemammography to gain acceptance in the medical establishment. These experiments produced data that were useful in two key medical studies that addressed the diagnostic accuracy of compressed satellite transmitted digital mammography images. The results of these studies will also be discussed.

  1. Pseudo force acting between bodies

    NASA Astrophysics Data System (ADS)

    Baruah, Abhinav Ray; Deva, Anish; Sarma, Arun

    It has been shown that a non-contact force acts between two macroscopic physical objects held close together, which is not associated with the gravitational and electrostatic force. An experiment was conducted with objects of different mass, material and geometry to find the magnitude and properties of this apparent or pseudo force. The order of magnitude was found to be 10-5 and it remained constant for all types of objects while only the coefficient increased as the distance between the objects reduced. It only started acting at small distances and failed to make a body move if it experienced static friction from any contact surface. The nature of the force was found to be attractive as well as repulsive. Due to gravitation being a solely attractive force, it was eliminated as a possible reason for the pseudo force. The experiment was performed twice, once by grounding the apparatus and then again without grounding. The order of the force remained the same for both cases. As the test objects were held by hand, they were grounded through the human body. Also, none of the objects used were in contact with each other for the duration of this work, preventing any contact electrification. Due to these factors, the force was not considered electrostatic in nature.

  2. Nature of the binding interaction for 50 structurally diverse chemicals with rat estrogen receptors

    EPA Science Inventory

    This study was conducted to characterize the estrogen receptor (ER)-binding affinities of 50 chemicals selected from among the high production volume chemicals under the U.S. EPA's (U.S. Environmental Protection Agency's) Toxic Substances Control Act inventory. The chemicals were...

  3. 76 FR 19096 - National Starch and Chemical Company, Salisbury, Rowan County, North Carolina; Notice of Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    ... AGENCY National Starch and Chemical Company, Salisbury, Rowan County, North Carolina; Notice of... Liability Act (CERCLA), concerning the National Starch and Chemical Company Site located in Salisbury, Rowan..., identified by Docket ID No. EPA-RO4- SFUND-2011-0278 or Site name National Starch and Chemical...

  4. 40 CFR 749.68 - Hexavalent chromium-based water treatment chemicals in cooling systems.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... tower used to remove heat from industrial processes, chemical reactions, or plants producing electrical... treatment chemicals in cooling systems. 749.68 Section 749.68 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT WATER TREATMENT CHEMICALS Air Conditioning...

  5. 40 CFR 749.68 - Hexavalent chromium-based water treatment chemicals in cooling systems.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... tower used to remove heat from industrial processes, chemical reactions, or plants producing electrical... treatment chemicals in cooling systems. 749.68 Section 749.68 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT WATER TREATMENT CHEMICALS Air Conditioning...

  6. 40 CFR 749.68 - Hexavalent chromium-based water treatment chemicals in cooling systems.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... tower used to remove heat from industrial processes, chemical reactions, or plants producing electrical... treatment chemicals in cooling systems. 749.68 Section 749.68 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT WATER TREATMENT CHEMICALS Air Conditioning...

  7. The Equality Act 2010 and mental health.

    PubMed

    Lockwood, Graeme; Henderson, Claire; Thornicroft, Graham

    2012-03-01

    One aim of the Equality Act 2010 is to protect people with disabilities and prevent disability discrimination. We review the key provisions of the Act relevant to disability discrimination with respect to mental illness.

  8. VIS/ACT: The next episode

    NASA Technical Reports Server (NTRS)

    Maney, Tucker; Hamburger, Henry

    1993-01-01

    VIS/ACT is a multi-media educational system for aircrew coordination training (ACT). Students view video segments, answer questions that are adjusted to individual performance, and engage in related activities. Although the system puts the student in a reactive critiquing role, it has proved effective in improving performance on active targeted ACT skills, in group simulation tasks. VIS/ACT itself is the product of coordination among three Navy agencies.

  9. 29 CFR 4.103 - The Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true The Act. 4.103 Section 4.103 Labor Office of the Secretary of Labor LABOR STANDARDS FOR FEDERAL SERVICE CONTRACTS Application of the McNamara-O'Hara Service Contract Act Introductory § 4.103 The Act. The McNamara-O'Hara Service Contract Act of 1965 (Pub. L....

  10. 29 CFR 4.103 - The Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true The Act. 4.103 Section 4.103 Labor Office of the Secretary of Labor LABOR STANDARDS FOR FEDERAL SERVICE CONTRACTS Application of the McNamara-O'Hara Service Contract Act Introductory § 4.103 The Act. The McNamara-O'Hara Service Contract Act of 1965 (Pub. L....

  11. CHEMICAL PROCESSES IN PROTOPLANETARY DISKS

    SciTech Connect

    Walsh, Catherine; Millar, T. J.; Nomura, Hideko

    2010-10-20

    We have developed a high-resolution combined physical and chemical model of a protoplanetary disk surrounding a typical T Tauri star. Our aims were to use our model to calculate the chemical structure of disks on small scales (submilliarcsecond in the inner disk for objects at the distance of Taurus, {approx}140 pc) to investigate the various chemical processes thought to be important in disks and to determine potential molecular tracers of each process. Our gas-phase network was extracted from the UMIST Database for Astrochemistry to which we added gas-grain interactions including freezeout and thermal and non-thermal desorption (cosmic-ray-induced desorption, photodesorption, and X-ray desorption), and a grain-surface network. We find that cosmic-ray-induced desorption has the least effect on our disk chemical structure while photodesorption has a significant effect, enhancing the abundances of most gas-phase molecules throughout the disk and affecting the abundances and distribution of HCN, CN, and CS, in particular. In the outer disk, we also see enhancements in the abundances of H{sub 2}O and CO{sub 2}. X-ray desorption is a potentially powerful mechanism in disks, acting to homogenize the fractional abundances of gas-phase species across the depth and increasing the column densities of most molecules, although there remain significant uncertainties in the rates adopted for this process. The addition of grain-surface chemistry enhances the fractional abundances of several small complex organic molecules including CH{sub 3}OH, HCOOCH{sub 3}, and CH{sub 3}OCH{sub 3} to potentially observable values (i.e., a fractional abundance of {approx}>10{sup -11}).

  12. 77 FR 24201 - Sunshine Act Meeting Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-23

    ... Conviction Records in Employment Decisions under Title VII of the Civil Rights Act of 1964, and 3... Complaint Appeals. Note: In accordance with the Sunshine Act, the open session of the meeting will be open... COMMISSION Sunshine Act Meeting Notice AGENCY HOLDING THE MEETING: Equal Employment Opportunity...

  13. ACT Assessment Results, 1994: Summary Report. National.

    ERIC Educational Resources Information Center

    American Coll. Testing Program, Iowa City, IA.

    This report presents information about the performance of the 1994 graduating seniors nationwide who took the ACT Assessment as juniors or seniors. Average scores are on the scale for the Enhanced ACT Assessment, which was introduced in 1989. It must be recalled that ACT-tested seniors may not be representative of the total population of…

  14. 7 CFR 29.13 - The act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false The act. 29.13 Section 29.13 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Regulations Definitions § 29.13 The act. The Tobacco Inspection Act, approved August 23, 1935....

  15. 7 CFR 1205.10 - Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1205.10 Section 1205.10 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND... for Conduct of Sign-up Period Definitions § 1205.10 Act. The term Act means the Cotton Research...

  16. 50 CFR 70.4 - Prohibited acts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Prohibited acts. 70.4 Section 70.4 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) MANAGEMENT OF FISHERIES CONSERVATION AREAS NATIONAL FISH HATCHERIES § 70.4 Prohibited acts. (a) The prohibited acts enumerated in part 27 of this...

  17. 75 FR 61994 - Privacy Act; Implementation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-07

    ... Office of the Secretary 31 CFR Part 1 RIN 1505-AC25 Privacy Act; Implementation AGENCY: Office of Foreign... requirements of the Privacy Act of 1974, as amended, the Department of the Treasury is amending its regulations... records by revising the number and title of the Privacy Act system of records for which an exemption...

  18. 75 FR 37287 - Privacy Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-29

    ... April 19, 2010 (75 FR 20298) for a public comment period to end on June 18, 2010. This rule amends the... CFR Part 200 RIN 0430-AA03 Privacy Act Regulations AGENCY: Recovery Accountability and Transparency... regulations implementing the Privacy Act of 1974 (Privacy Act), Public Law 93-579, 5 U.S.C. 552a. This...

  19. 76 FR 71293 - Privacy Act; Implementation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-17

    ... Office of the Secretary 31 CFR Part 1 RIN 1505-AC37 Privacy Act; Implementation AGENCY: Office of the Secretary, Treasury. ACTION: Proposed rule. SUMMARY: In accordance with the requirements of the Privacy Act... Identification Number Records'' from certain provisions of the Privacy Act. DATES: Comments must be received...

  20. 77 FR 57015 - Privacy Act; Implementation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ... of the Secretary 32 CFR Part 319 Privacy Act; Implementation AGENCY: Defense Intelligence Agency, DoD... that have been previously claimed for the records in another Privacy Act system of records. DIA is updating the DIA Privacy Act Program by adding the (k)(2) and (k)(5) exemptions to accurately describe...

  1. 7 CFR 1209.1 - Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE MUSHROOM PROMOTION, RESEARCH, AND CONSUMER INFORMATION ORDER Mushroom Promotion, Research, and Consumer Information Order Definitions § 1209.1 Act. Act means the Mushroom Promotion, Research, and Consumer Information Act of 1990, subtitle B of title XIX...

  2. 7 CFR 1209.1 - Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE MUSHROOM PROMOTION, RESEARCH, AND CONSUMER INFORMATION ORDER Mushroom Promotion, Research, and Consumer Information Order Definitions § 1209.1 Act. Act means the Mushroom Promotion, Research, and Consumer Information Act of 1990, subtitle B of title XIX...

  3. 7 CFR 1209.1 - Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE MUSHROOM PROMOTION, RESEARCH, AND CONSUMER INFORMATION ORDER Mushroom Promotion, Research, and Consumer Information Order Definitions § 1209.1 Act. Act means the Mushroom Promotion, Research, and Consumer Information Act of 1990, subtitle B of title XIX...

  4. 7 CFR 1209.1 - Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE MUSHROOM PROMOTION, RESEARCH, AND CONSUMER INFORMATION ORDER Mushroom Promotion, Research, and Consumer Information Order Definitions § 1209.1 Act. Act means the Mushroom Promotion, Research, and Consumer Information Act of 1990, subtitle B of title XIX...

  5. 7 CFR 1219.1 - Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE HASS AVOCADO PROMOTION, RESEARCH, AND INFORMATION Hass Avocado Promotion, Research, and Information Order Definitions § 1219.1 Act. Act means the Hass Avocado Promotion, Research, and Information Act of 2000, Public Law 106-387, 7 U.S.C....

  6. 7 CFR 1219.1 - Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE HASS AVOCADO PROMOTION, RESEARCH, AND INFORMATION Hass Avocado Promotion, Research, and Information Order Definitions § 1219.1 Act. Act means the Hass Avocado Promotion, Research, and Information Act of 2000, Public Law 106-387, 7 U.S.C....

  7. 7 CFR 1219.1 - Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE HASS AVOCADO PROMOTION, RESEARCH, AND INFORMATION Hass Avocado Promotion, Research, and Information Order Definitions § 1219.1 Act. Act means the Hass Avocado Promotion, Research, and Information Act of 2000, Public Law 106-387, 7 U.S.C....

  8. 7 CFR 1230.1 - Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE PORK PROMOTION, RESEARCH, AND CONSUMER INFORMATION Pork Promotion, Research, and Consumer Information Order Definitions § 1230.1 Act. Act means the Pork Promotion, Research, and Consumer Information Act of 1985 (7 U.S.C. 4801-4819) and any...

  9. 7 CFR 1230.1 - Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE PORK PROMOTION, RESEARCH, AND CONSUMER INFORMATION Pork Promotion, Research, and Consumer Information Order Definitions § 1230.1 Act. Act means the Pork Promotion, Research, and Consumer Information Act of 1985 (7 U.S.C. 4801-4819) and any...

  10. 7 CFR 1230.1 - Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE PORK PROMOTION, RESEARCH, AND CONSUMER INFORMATION Pork Promotion, Research, and Consumer Information Order Definitions § 1230.1 Act. Act means the Pork Promotion, Research, and Consumer Information Act of 1985 (7 U.S.C. 4801-4819) and any...

  11. 7 CFR 1230.1 - Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE PORK PROMOTION, RESEARCH, AND CONSUMER INFORMATION Pork Promotion, Research, and Consumer Information Order Definitions § 1230.1 Act. Act means the Pork Promotion, Research, and Consumer Information Act of 1985 (7 U.S.C. 4801-4819) and any...

  12. 7 CFR 1230.1 - Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE PORK PROMOTION, RESEARCH, AND CONSUMER INFORMATION Pork Promotion, Research, and Consumer Information Order Definitions § 1230.1 Act. Act means the Pork Promotion, Research, and Consumer Information Act of 1985 (7 U.S.C. 4801-4819) and any...

  13. 3 CFR - The Endangered Species Act

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 3 The President 1 2010-01-01 2010-01-01 false The Endangered Species Act Presidential Documents Other Presidential Documents Memorandum of March 3, 2009 The Endangered Species Act Memorandum for the Heads of Executive Departments and Agencies The Endangered Species Act (ESA), 16 U.S.C. 1531 et...

  14. 25 CFR 700.103 - Uniform Act.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false Uniform Act. 700.103 Section 700.103 Indians THE OFFICE OF NAVAJO AND HOPI INDIAN RELOCATION COMMISSION OPERATIONS AND RELOCATION PROCEDURES General Policies and Instructions Definitions § 700.103 Uniform Act. The term Uniform Act means the Uniform...

  15. 25 CFR 700.103 - Uniform Act.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false Uniform Act. 700.103 Section 700.103 Indians THE OFFICE OF NAVAJO AND HOPI INDIAN RELOCATION COMMISSION OPERATIONS AND RELOCATION PROCEDURES General Policies and Instructions Definitions § 700.103 Uniform Act. The term Uniform Act means the Uniform...

  16. 25 CFR 700.103 - Uniform Act.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Uniform Act. 700.103 Section 700.103 Indians THE OFFICE OF NAVAJO AND HOPI INDIAN RELOCATION COMMISSION OPERATIONS AND RELOCATION PROCEDURES General Policies and Instructions Definitions § 700.103 Uniform Act. The term Uniform Act means the Uniform...

  17. 25 CFR 700.103 - Uniform Act.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false Uniform Act. 700.103 Section 700.103 Indians THE OFFICE OF NAVAJO AND HOPI INDIAN RELOCATION COMMISSION OPERATIONS AND RELOCATION PROCEDURES General Policies and Instructions Definitions § 700.103 Uniform Act. The term Uniform Act means the Uniform...

  18. 7 CFR 1220.101 - Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Soybean Promotion and Research Order Definitions § 1220.101 Act. The term Act means the Soybean Promotion, Research, and Consumer Information Act, subtitle E of title XIX, of the...

  19. 7 CFR 1220.101 - Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Soybean Promotion and Research Order Definitions § 1220.101 Act. The term Act means the Soybean Promotion, Research, and Consumer Information Act, subtitle E of title XIX, of the...

  20. 7 CFR 1220.101 - Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Soybean Promotion and Research Order Definitions § 1220.101 Act. The term Act means the Soybean Promotion, Research, and Consumer Information Act, subtitle E of title XIX, of the...