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Sample records for act tsca chemical

  1. Request for Correction 15003 - Information Quality Act request for Correction of the TSCA Work Plan

    EPA Pesticide Factsheets

    This RFC concerns the Information Quality Act request for correction of the TSCA Work Plan for Chemical Assessments: 20154 Update and the TSCA Work Plan Chemicals: Methods Document (February 2012) regarding assessment of phthalic anhydride

  2. Toxic Substances Control Act (TSCA) and Federal Facilities

    EPA Pesticide Factsheets

    The Toxic Substances Control Act (TSCA) of 1976 provides EPA with authority to require reporting, record-keeping and testing requirements, and restrictions relating to chemical substances and/or mixtures.

  3. TSCA Chemical Data Reporting Fact Sheet: Articles

    EPA Pesticide Factsheets

    This fact sheet provides guidance on classifying articles under the Toxic Substances Control Act (TSCA) and determining the applicability of EPA’s articles exclusion policy for purposes of the Chemical Data Reporting (CDR) rule. The primary goal of this document is to help the regulated community comply with the requirements of the CDR rule.

  4. TSCA Chemical Data Reporting Fact Sheet: Chemical Substances which are the Subject of Certain TSCA Actions

    EPA Pesticide Factsheets

    This fact sheet provides guidance for people who may be subject to the Chemical Data Reporting (CDR) rule on how their requirements for reporting for 2016 may be affected when chemical substances are the subject of certain TSCA actions.

  5. Predictive Models and Tools for Assessing Chemicals under the Toxic Substances Control Act (TSCA)

    EPA Pesticide Factsheets

    EPA has developed databases and predictive models to help evaluate the hazard, exposure, and risk of chemicals released to the environment and how workers, the general public, and the environment may be exposed to and affected by them.

  6. Certain Chemical Substances Containing Varying Carbon Chain Lengths (Alkyl Ranges Using the Cx-y Notation) on the TSCA Inventory

    EPA Pesticide Factsheets

    This paper explains the conventions that are applied to certain listings of chemical substances containing ranges of alkyl chain lengths (i.e., carbon chains of varying lengths) for chemical substances on the Toxic Substances Control Act (TSCA)

  7. Structure activity relationships to assess new chemicals under TSCA

    SciTech Connect

    Auletta, A.E.

    1990-12-31

    Under Section 5 of the Toxic Substances Control Act (TSCA), manufacturers must notify the US Environmental Protection Agency (EPA) 90 days before manufacturing, processing, or importing a new chemical substance. This is referred to as a premanufacture notice (PMN). The PMN must contain certain information including chemical identity, production volume, proposed uses, estimates of exposure and release, and any health or environmental test data that are available to the submitter. Because there is no explicit statutory authority that requires testing of new chemicals prior to their entry into the market, most PMNs are submitted with little or no data. As a result, EPA has developed special techniques for hazard assessment of PMN chemicals. These include (1) evaluation of available data on the chemical itself, (2) evaluation of data on analogues of the PMN, or evaluation of data on metabolites or analogues of metabolites of the PMN, (3) use of quantitative structure activity relationships (QSARs), and (4) knowledge and judgement of scientific assessors in the interpretation and integration of the information developed in the course of the assessment. This approach to evaluating potential hazards of new chemicals is used to identify those that are most in need of addition review of further testing. It should not be viewed as a replacement for testing. 4 tabs.

  8. Confidential Business Information under TSCA

    EPA Pesticide Factsheets

    This website informs businesses, policymakers, and the public about the confidential business information (CBI) provisions of § 14 of the Toxic Substances Control Act (TSCA), as amended by the Frank R. Lautenberg Chemical Safety for the 21st Century Act.

  9. Frequent Questions about TSCA CBI

    EPA Pesticide Factsheets

    General Questions and Answers Concerning Confidential Business Information (CBI) Provisions of the Toxic Substances Control Act (TSCA), as amended by the Frank R. Lautenberg Chemical Safety for the 21st Century Act

  10. TSCA Work Plan Chemical Technical Supplement – Physicochemical Properties and Environmental Fate of the Brominated Phthalates Cluster (BPC) Chemicals

    EPA Pesticide Factsheets

    TSCA Work Plan Chemical Technical Supplement – Physicochemical Properties and Environmental Fate of the Brominated Phthalates Cluster (BPC) Chemicals -- Brominated Phthalates Cluster Flame Retardants.

  11. 76 FR 50815 - TSCA Inventory Update Reporting Modifications; Chemical Data Reporting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-16

    ... subset of chemical substances listed on the TSCA Inventory. 4. To improve the usefulness of the... Update Reporting Modifications; Chemical Data Reporting; Final Rule #0;#0;Federal Register / Vol. 76 , No... Parts 704, 710, and 711 RIN 2070-AJ43 TSCA Inventory Update Reporting Modifications; Chemical...

  12. Sunset Dates of Chemicals Subject to Final TSCA Section 4 and Related 12(b) Actions

    EPA Pesticide Factsheets

    This Table lists, in ascending chemical Abstract Service (CAS) Registry number order, all chemical substances and mixtures that are and/or have been the subject of final TSCA Section 4 test rules and/or TSCA Section 4 enforceable consent agreements/orders.

  13. Sunset dates of chemicals subject to final TSCA section 4: test requirements and related section 12(b) actions

    EPA Pesticide Factsheets

    This table lists all chemical substances and mixtures that are and/or have been the subject of final TSCA Section 4 test rules and/or TSCA Section 4 enforceable consent agreements/orders (ECAs) issued under the TSCA Existing Chemicals Testing Program.

  14. Toxic Substances Control Act (TSCA) TSCATS (test submissions database) comprehensive update (raw data file)

    SciTech Connect

    1999-09-01

    TSCATS (Toxic Substances Control Act Test Submissions) is an online index to unpublished, nonconfidential studies covering chemical testing results and adverse effects of chemicals on health and ecological systems. The studies are submitted by US industry to EPA under several sections of the Toxic Substances Control Act (TSCA). There are four types of documents in the database: Section 4 chemical testing results, Section 8(d) health and safety studies, Section 8(e) substantial risk of injury to health or the environment notices, and voluntary documents submitted to EPA known as a For Your Information (FYI) notice. TSCATS contains information that is pertinent to the risk assessment and hazard evaluation processes. The information can be used in conjunction with published material and is a valuable source along with or in the absence of published data. The data are used by federal and state agencies, researchers, toxicologists, risk assessors, the regulated industry, attorneys, trade and professional associations. TSCATS was developed to make ongoing and completed chemical testing studies available to the public and includes chemical exposure studies, epidemiology, environmental fate, monitoring, episodic incidents, such as spills and case reports. There are 81,000 studies on 6,700 unique chemical substances contained in 23,000 documents. On average three or four individual studies are extracted from each document. Studies are indexed under three broad categories: health effects, ecological effects and environmental fate. Additional controlled vocabulary terms are assigned to describe the experimental protocol and test observations. A TSCATS record also includes: the chemical name, CAS (Chemical Abstracts Service) Registry Number, Section of TSCA, title, document number, microfiche number, submitting organization, and performing organization. A select number of studies also have abstracts. Microfiche copies of the full-text documents of the unpublished reports

  15. Assessments for TSCA Work Plan Chemicals

    EPA Pesticide Factsheets

    EPA's assessing and managing risk programs address pollution prevention, risk assessment, hazard and exposure assessment and/or characterization, and risk management for chemicals substances in commercial use.

  16. TSCA Work Plan Chemical Risk Assessment: 1 ...

    EPA Pesticide Factsheets

    1-Bromopropane (CASRN 106-94-5): or 1-BP is a volatile organic chemical that is considered moderately persistent in the environment but does not have the potential to bioaccumulate in fish or other animals. The majority of the 1-BP production volume (~ 47%) is used as a vapor degreaser for optics electronics, plastics, and metals. 1-BP also is used as an aerosol solvent in cleaning products, as a spray fixative in arts and crafts, and as a spot cleaner in various industrial/commercial/consumer sectors. Focus of the Risk Assessment: The assessment will focus on uses of 1-BP in commercial (i.e., vapor degreasing, spray adhesives, and dry cleaning) and consumer applications (i.e., aerosol solvent cleaners and spray adhesives). Given the range of endpoints (i.e., cancer, non-cancer; the latter includes potential effects on the developing fetus), susceptible populations are expected to include adults (including pregnant women) in commercial uses and children (as bystanders) and adults of all ages (including pregnant women) for consumer uses. Thus, the assessment will focus on all humans/lifestages. EPA anticipates issuing draft risk assessments for public review and comment as they are completed. At the conclusion of the review process, if an assessment of specific uses indicates significant risk, EPA will evaluate and pursue appropriate risk reduction actions, as warranted. If an assessment indicates no significant risk, EPA will conclude its work on the a

  17. The TSCA interagency testing committee`s approaches to screening and scoring chemicals and chemical groups: 1977-1983

    SciTech Connect

    Walker, J.D.

    1990-12-31

    This paper describes the TSCA interagency testing committee`s (ITC) approaches to screening and scoring chemicals and chemical groups between 1977 and 1983. During this time the ITC conducted five scoring exercises to select chemicals and chemical groups for detailed review and to determine which of these chemicals and chemical groups should be added to the TSCA Section 4(e) Priority Testing List. 29 refs., 1 fig., 2 tabs.

  18. TSCA Section 21 Petition Requesting EPA to Promulgate TSCA Section 4 and 8 Rules Concerning Oil and Gas Exploration and Production Chemicals and Mixtures

    EPA Pesticide Factsheets

    This petition requests EPA to promulgate regulations under TSCA Section 4 and 8 rules requiring toxicity testing and reporting of health and safety studies on oil and gas exploration and production chemicals.

  19. Questions and Answers for Reporting for the 2006 Partial Updating of the TSCA Chemical Inventory Database: Inorganic Chemicals Addendum

    EPA Pesticide Factsheets

    This document addresses specific questions related to reporting inorganic chemicals under the IUR and is an addendum to the Questions and Answers for Reporting for the 2006 Partial Updating of the TSCA Chemical Inventory Database (Questions and Answers Document).

  20. Nanoscale Substances on the TSCA Inventory

    EPA Pesticide Factsheets

    This document is to help the regulated community comply with the requirements of the Toxic Substances Control Act (TSCA) Section 5 Premanufacturing Notice (PMN) Program for nanoscale chemical substances.

  1. Toxic Substances Control Act (TSCA) TSCATS (test submissions database) comprehensive update, August 1999

    SciTech Connect

    1999-08-01

    TSCATS (Toxic Substances Control Act Test Submissions) is an online index to unpublished, nonconfidential studies covering chemical testing results and adverse effects of chemicals on health and ecological systems. There are four types of documents in the database: Section 4 chemical testing results, Section 8(d) health and safety studies, Section 8(e) substantial risk of injury to health or the environment notices, and voluntary documents submitted to EPA known as a For Your Information (FYI) notice. TSCATS contains information that is pertinent to the risk assessment and hazard evaluation processes. The information can be used in conjunction with published material and is a valuable source along with or in the absence of published data. The data are used by federal and state agencies, researchers, toxicologists, risk assessors, the regulated industry, attorneys, trade and professional associations. TSCATS was developed to make ongoing and completed chemical testing studies available to the public.There are 81,000 studies on 6,700 unique chemical substances are contained in 23,000 documents. Studies are indexed under three broad categories: health effects, ecological effects and environmental fate. Additional controlled vocabulary terms are assigned to describe the experimental protocol and test observations. A TSCATS record also includes: the chemical name, CAS (Chemical Abstracts Service) Registry Number, Section of TSCA, title, document number, microfiche number, submitting organization, and performing organization. A select number of studies also have abstracts. Microfiche copies of the full-text documents of the unpublished reports referenced by TSCATS are directly available from NTIS. The titles of these 23,000 unpublished reports can be searched directly on the NTIS web site at www.ntis.gov/yellowbk/1nty834.htm.

  2. 76 FR 54932 - TSCA Inventory Update Reporting Modifications; Chemical Data Reporting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-06

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY 40 CFR Parts 704, 710, and 711 RIN 2070-AJ43 TSCA Inventory Update Reporting Modifications; Chemical Data Reporting Correction In rule document 2011-19922, appearing on pages 50816-50879 in the...

  3. Impacts & Compliance Implementation Plans & Required Deviations for Toxic Substance Control Act (TSCA) Regulation of Double Shell Tanks (DST)

    SciTech Connect

    MULKEY, C.H.

    2000-08-22

    In May 2000, the U.S. Department of Energy, Office of River Protection (DOE-ORP) and the U.S. Environmental Protection Agency (EPA) held meetings regarding the management of polychlorinated biphenyls (PCBs) in the Hanford tank waste. It was decided that the radioactive waste currently stored in the double-shell tanks (DSTs) contain waste which will become subject to the Toxic Substance Control Act (TSCA) (40 CFR 761). As a result, DOE-ORP directed the River Protection Project tank farm contractor (TFC) to prepare plans for managing the PCB inventory in the DSTs. Two components of the PCB management plans are this assessment of the operational impacts of TSCA regulation and the identifications of deviations from TSCA that are required to accommodate tank farm unique limitations. This plan provides ORP and CH2M HILL Hanford Group, Inc. (CHG) with an outline of TSCA PCB requirements and their applicability to tank farm activities, and recommends a compliance/implementation approach. Where strict compliance is not possible, the need for deviations from TSCA PCB requirements is identified. The purpose of assembling this information is to enhance the understanding of PCB management requirements, identify operational impacts and select impact mitigation strategies. This information should be useful in developing formal agreements with EPA where required.

  4. Oak Ridge Toxic Substances Control Act (TSCA) Incinerator test bed for continuous emissions monitoring systems (CEMS)

    SciTech Connect

    Gibson, L.V. Jr.

    1997-12-31

    The Toxic Substances Control Act (TSCA) Incinerator, located on the K-25 Site at Oak Ridge, Tennessee, continues to be the only operational incinerator in the country that can process hazardous and radioactively contaminated polychlorinated biphenyl (PCB) waste. During 1996, the US Department of Energy (DOE) Environmental Management Office of Science and Technology (EM-50) and Lockheed Martin Energy Systems established a continuous emissions monitoring systems (CEMS) test bed and began conducting evaluations of CEMS under development to measure contaminants from waste combustion and thermal treatment stacks. The program was envisioned to promote CEMS technologies meeting requirements of the recently issued Proposed Standards for Hazardous Waste Combustors as well as monitoring technologies that will allay public concerns about mixed waste thermal treatment and accelerate the development of innovative treatment technologies. Fully developed CEMS, as well as innovative continuous or semi-continuous sampling systems not yet interfaced with a pollutant analyzer, were considered as candidates for testing and evaluation. Complementary to other Environmental Protection Agency and DOE sponsored CEMS testing and within compliant operating conditions of the TSCA Incinerator, prioritization was given to multiple metals monitors also having potential to measure radionuclides associated with particulate emissions. In August 1996, developers of two multiple metals monitors participated in field activities at the incinerator and a commercially available radionuclide particulate monitor was acquired for modification and testing planned in 1997. This paper describes the CEMS test bed infrastructure and summarizes completed and planned activities.

  5. TSCA Chemical Data Reporting Fact Sheet: Imported Articles

    EPA Pesticide Factsheets

    This fact sheet provides guidance and sample reporting scenarios on the reporting exemption for the import of a chemical substance as part of an article, for purposes of the Chemical Data Reporting (CDR) rule.

  6. TSCA Chemical Data Reporting Fact Sheet: Toll Manufacturing

    EPA Pesticide Factsheets

    This fact sheet provides information on existing Chemical Data Reporting (CDR) regulations to persons who are involved in toll manufacturing of chemical substances which may be subject to the CDR rule.

  7. The TSCA Interagency Testing Committee (ITC) proposed strategy for identifying and coordinating U.S. government data needs for endocrine-disrupting chemicals

    SciTech Connect

    Walker, J.D.

    1995-12-31

    The ITC`s Endocrine-Disrupting Chemicals Subcommittee will implement a proposed strategy for identifying and coordinating the US government ecological and health effects data needs for endocrine-disrupting chemicals, These include chemicals with potential to cause reproductive, developmental, immunological, neurologic or other biological effects by adversely affecting endocrine tissues, hormones or receptors in fish, wildlife or humans. To meet these needs, the Subcommittee will consider three options. First, the information collecting authority of the Toxic Substances Control Act (TSCA) will be considered as a cost-effective mechanism to rapidly (within 60 days) obtain unpublished health and ecological effects studies related to reproductive effects and endocrine-disrupting activity. Second, the chemical testing authority of TSCA will be considered as a method to request that the manufacturers of endocrine-disrupting chemicals conduct tests that are amenable to standardization. Third, consideration will be given to coordinating standardized testing with testing related to research and to using the results of this research to develop standardized methods for assessing the effects of endocrine-disrupting chemicals. The Subcommittee will focus on 16 alkylphenol and alkylphenol ethoxylates with 1989 production or importation volumes greater than 1 million pounds that were identified using the Substructure based Computerized Chemical Selection Expert System (SuCCSES). The ITC`s proposed strategy will be discussed.

  8. TSCA Work Plan Chemical Risk Assessment: 1-Bromopropane

    EPA Science Inventory

    1-Bromopropane (CASRN 106-94-5): or 1-BP is a volatile organic chemical that is considered moderately persistent in the environment but does not have the potential to bioaccumulate in fish or other animals. The majority of the 1-BP production volume (~ 47%) is used as a vapor deg...

  9. 76 FR 38170 - Toxic Substances Control Act Chemical Testing; Receipt of Test Data

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... AGENCY Toxic Substances Control Act Chemical Testing; Receipt of Test Data AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: This notice announces EPA's receipt of test data on 12 chemicals listed in the Toxic Substance Control Act (TSCA) section 4 test rule titled ``Testing of...

  10. 76 FR 38169 - Toxic Substances Control Act Chemical Testing; Receipt of Test Data

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... AGENCY Toxic Substances Control Act Chemical Testing; Receipt of Test Data AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: This notice announces EPA's receipt of test data on five chemicals listed in the Toxic Substances Control Act (TSCA) section 4 test rule titled ``In Vitro...

  11. Field testing of particulate matter continuous emission monitors at the DOE Oak Ridge TSCA incinerator. Toxic Substances Control Act.

    PubMed

    Dunn, James E; Davis, Wayne T; Calcagno, James A; Allen, Marshall W

    2002-01-01

    A field study to evaluate the performance of three commercially available particulate matter (PM) continuous emission monitors (CEMs) was conducted in 1999-2000 at the US Department of Energy (DOE) Toxic Substances Control Act (TSCA) Incinerator. This study offers unique features that are believed to enhance the collective US experience with PM CEMs. The TSCA Incinerator is permitted to treat PCB-contaminated RCRA hazardous low-level radioactive wastes. The air pollution control system utilizes MACT control technology and is comprised of a rapid quench, venturi scrubber, packed bed scrubber, and two ionizing wet scrubbers in series, which create a saturated flue gas that must be conditioned by the CEMs prior to measurement. The incinerator routinely treats a wide variety of wastes including high and low BTU organic liquids, aqueous, and solid wastes. The various possible combinations for treating liquid and solid wastes may present a challenge in establishing a single, acceptable correlation relationship for individual CEMs. The effect of low-level radioactive material present in the waste is a unique site-specific factor not evaluated in previous tests. The three systems chosen for evaluation were two beta gauge devices and a light scattering device. The performance of the CEMs was evaluated using the requirements in draft Environmental Protection Agency (EPA) Performance Specification 11 (PS11) and Procedure 2. The results of Reference Method 5i stack tests for establishing statistical correlations between the reference method data and the CEMs responses are discussed.

  12. TSCA Scientific Peer Review Committees

    EPA Pesticide Factsheets

    The SACC will provide independent scientific advice and recommendations to the EPA on the scientific basis for risk assessments, methodologies, and pollution prevention measures and approaches for chemicals regulated under TSCA.

  13. Dynamic computer model for heat transfer and incineration in the Oak Ridge TSCA (Toxic Substances Control Act) hazardous waste incinerator

    SciTech Connect

    Clinton, J.H.

    1989-01-01

    The Oak Ridge Toxic Substances Control Act (TSCA) incinerator was designed to burn toxic wastes such as PCBs. During the course of certification, concern was expressed by the Environmental Protection Agency that unburned PCBs might not continue to be destructed if the ''burning'' in the incinerator ceased. For example, it is possible that the flow of auxiliary fuel could be interrupted during the course of incinerator operation. The situation could occur at the time when a fresh batch of waste was introduced into the incinerator which would be the worst time for normal incinerator operation to cease. In response to the question concerning the destruction of PCBs during such an accidental cooling period, a dynamic model was constructed to approximate the situation, and thus obtain an estimate of the time period that the exit gas would remain above the necessary temperature required to detoxify the undesirable substance.

  14. TSCA Chemical Data Reporting Fact Sheet: Reporting Manufactured Chemical Substances from Metal Mining and Related Activities

    EPA Pesticide Factsheets

    This fact sheet provides guidance on the Chemical Data Reporting (CDR) rule requirements related to the reporting of mined metals, intermediates, and byproducts manufactured during metal mining and related activities.

  15. Partial Updating of TSCA Inventory DataBase; Production and Site Reports; Final Rule

    EPA Pesticide Factsheets

    A partial updating of the TSCA inventory database. The final rule requires manufacturers and importers of certain chemical substances included on the TSCA Chemical Substances Inventory to report current data on the production volume, plant site, etc.

  16. 77 FR 61117 - Significant New Use Rules on Certain Chemical Substances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-05

    ...EPA is promulgating significant new use rules (SNURs) under the Toxic Substances Control Act (TSCA) for 78 chemical substances which were the subject of premanufacture notices (PMNs). Seven of these chemical substances are subject to TSCA section 5(e) consent orders issued by EPA. This action requires persons who intend to manufacture, import, or process any of these 78 chemical substances for......

  17. Human health and the environment can't wait for reform: current opportunities for the federal government and states to address chemical risks under the Toxic Substances Control Act.

    PubMed

    Trevisan, Lauren

    2011-01-01

    Expressing its concern about growing rates of cancer and other diseases, coupled with the lack of data about the effect of the thousands of chemicals used in U.S. society, in 1976 Congress enacted the Toxic Substances Control Act (TSCA). Congress intended for TSCA to shed new light on chemical risks and provide the U.S. Environmental Protection Agency (EPA) with a set of tools to address those risks and protect human health and the environment. In the years since TSCA's passage, the procedural hurdles and the difficult-to-meet legal standards built into the statute, along with a court decision rejecting EPA's use of its authority to ban dangerous chemicals, have impeded EPA's ability to regulate chemical use and manufacture. This Comment argues that both the EPA and state governments have the authority to act now to address the risks posed by dangerous chemicals. By utilizing certain sections of the statute in new and aggressive ways, EPA can effectively address chemical risks. Further, this Comment argues that TSCA's preemption provision affords states leeway to continue to regulate the use of chemicals within their borders. Though reform of TSCA is necessary, EPA and states can effectively protect against chemical risks in the near-term by using the full extent of their authority under the current law.

  18. About Using Predictive Models and Tools To Assess Chemicals under TSCA

    EPA Pesticide Factsheets

    As part of EPA's effort to promote chemical safety, OPPT provides public access to predictive models and tools which can help inform the public on the hazards and risks of substances and improve chemical management decisions.

  19. TSCA Chemical Data Reporting Fact Sheet: Reporting for Electricity Generating Sites

    EPA Pesticide Factsheets

    This fact sheet provides information on existing Chemical Data Reporting (CDR) rule requirements related to the reporting of chemical substances manufactured during operations conducted at electricity generating sites, such as utilities.

  20. TSCA Work Plan Chemical Risk Assessment Methylene Chloride: Paint Stripping Use

    EPA Pesticide Factsheets

    This risk assessment addresses DCM, a volatile organic compound (VOC) that is used as a solvent in a wide range of industrial, commercial and consumer use applications, such as adhesives, paint stripping, pharmaceuticals, metal cleaning, chemical processin

  1. TSCA Chemical Data Reporting Fact Sheet: Byproducts Reporting for the Printed Circuit Board Industry

    EPA Pesticide Factsheets

    This fact sheet provides information on existing Chemical Data Reporting (CDR) rule requirements related to byproducts reporting by persons who manufacture printed circuit boards and may be subject to CDR.

  2. 77 FR 15609 - Revocation of TSCA Section 4 Testing Requirements for Certain High Production Volume Chemical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-16

    ... boiling point listed for that chemical substance in the ``Handbook of Chemistry and Physics'' (Ref. 21... partition coefficient which were obtained by using an alternative method, due to the extremely low predicted... temperature had been reported (Ref. 45). EPA accepted the submitted data on water solubility as satisfying...

  3. 77 FR 36170 - TSCA Inventory Update Reporting Modifications; Chemical Data Reporting; 2012 Submission Period...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-18

    ... not have substantial direct effects on State or tribal governments, on the relationship between the... instructions and additional information about the docket available at http://www.epa.gov/dockets . FOR FURTHER INFORMATION CONTACT: Chenise Farquharson, Chemical Control Division (7405M), Office of Pollution...

  4. Guidance Documents on Substantial Risk Notifications under TSCA

    EPA Pesticide Factsheets

    Guidance documents for TSCA Section 8(e) which states 'Any person who manufactures a chemical substance and obtains information that the chemical is harmful to health or the environment shall inform the EPA.'

  5. 40 CFR 710.25 - Chemical substances for which information must be reported.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS 2002 Inventory Update Reporting... the Master Inventory File at the beginning of a reporting period described in § 710.33, unless...

  6. 40 CFR 710.45 - Chemical substances for which information must be reported.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS Inventory Update Reporting for... substance which is in the Master Inventory File at the beginning of a submission period described in §...

  7. TSCA Work Plan Chemical Problem Formulation and Initial Assessment Tetrabromobisphenol A and Related Chemicals Cluster Flame Retardants

    EPA Pesticide Factsheets

    EPA released a problem formulation for TBBPA and related chemicals used as a flame retardants in plastics/printed circuit boards for electronics. The goal of this problem formulation was to identify scenarios where further risk analysis may be necessary.

  8. 77 FR 37609 - Significant New Use Rule on Certain Chemical Substances; Withdrawal of Significant New Use Rule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-22

    ... Control Act (TSCA) for chemical substances identified generically as complex strontium aluminum, rare... complex strontium aluminum, rare earth doped, which were the subject of PMNs P-12-22, P-12-23, P-12-24,...

  9. Toxic Substances Control Act (TSCA) Polychlorinated Biphenyl (PCB)/Radioactive Waste Annual Inventory for Calendar Year 2014

    SciTech Connect

    Layton, Deborah L.

    2015-06-01

    The Toxic Substances Control Act, 40 CFR 761.65(a)(1) provides an exemption from the one year storage time limit for PCB/radioactive waste. PCB/radioactive waste may exceed the one year time limit provided that the provisions at 40 CFR 761.65(a)(2)(ii) and 40 CFR 761.65(a)(2)(iii) are followed. These two subsections require, (ii) "A written record documenting all continuing attempts to secure disposal is maintained until the waste is disposed of" and (iii) "The written record required by subsection (ii) of this section is available for inspection or submission if requested by EPA." EPA Region 10 has requested the Department of Energy (DOE) to submit an inventory of radioactive-contaminated PCB waste in storage at the Idaho National Laboratory (INL) for the previous calendar year. The annual inventory is separated into two parts, INL without Advanced Mixed Waste Treatment Project (AMWTP) (this includes Battelle Energy Alliance, LLC, CH2M-WG Idaho, LLC, and the Naval Reactors Facility), and AMWTP.

  10. Toxic Substances Control Act (TSCA) Polychlorinated Biphenyl (PCB)/Radioactive Waste Annual Inventory for Calendar Year 2013

    SciTech Connect

    no author on report

    2014-06-01

    The Toxic Substances Control Act, 40 CFR 761.65(a)(1) provides an exemption from the one year storage time limit for PCB/radioactive waste. PCB/radioactive waste may exceed the one year time limit provided that the provisions at 40 CFR 761.65(a)(2)(ii) and 40 CFR 761.65(a)(2)(iii) are followed. These two subsections require, (ii) "A written record documenting all continuing attempts to secure disposal is maintained until the waste is disposed of" and (iii) "The written record required by subsection (ii) of this section is available for inspection or submission if requested by EPA." EPA Region 10 has requested the Department of Energy (DOE) to submit an inventory of radioactive-contaminated PCB waste in storage at the Idaho National Laboratory (INL) for the previous calendar year. The annual inventory is separated into two parts, INL without Advanced Mixed Waste Treatment Project (AMWTP) (this includes Battelle Energy Alliance, LLC, CH2M-WG Idaho, LLC, and the Naval Reactors Facility), and AMWTP.

  11. TSCA Section 21 Petition for Section 8(a) Partial Exemption

    EPA Pesticide Factsheets

    This petition requests EPA to amend the TSCA Section 8 Chemical Data Reporting (CDR) partially exempted chemical list set forth in the U.S. Environmental Protection Agency’s (EPA) regulations at 40 C.F.R. Section 711.6(b)(1).

  12. 78 FR 41768 - Chemical Substances and Mixtures Used in Oil and Gas Exploration or Production; TSCA Section 21...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-11

    ... processors of E&P chemical substances and mixtures to develop test data sufficient to evaluate the toxicity... and processors of E&P [chemical substances and mixtures] to develop test data to evaluate the toxicity...(a) to require manufacturers and processors of oil and gas exploration and production (E&P)...

  13. EPA Pre-Manufacture Notice Review Determinations under Amended TSCA

    EPA Pesticide Factsheets

    This page describes the regulatory determination EPA has made following review of pre-manufacture notifications under section 5 of TSCA, as amended by the Frank R. Lautenberg Chemical Safety for the 21st Century law, P.L. 114-182.

  14. The drive for a safer chemicals policy in the United States.

    PubMed

    Belliveau, Michael E

    2011-01-01

    This article analyzes the history, policies and politics of the modern era of safer chemical policy reform in the United States. In the last decade, state laws have modeled a chemical policy framework to phase out unnecessary dangerous chemicals in favor of safer alternatives. These state drivers, along with market campaigns to reduce downstream business use of hazardous chemicals, have weakened the chemical industry's resistance to fixing the broken federal chemical safety system. The obsolete Toxic Substances Control Act of 1976 (TSCA) has failed to protect public health and the environment and has stifled innovation toward greener chemistry. Health advocates with a progressive policy vision tempered by legislative pragmatism have launched a TSCA reform campaign to challenge chemical industry power in a weak Congress. The opportunity and limits to winning meaningful TSCA reform are characterized and marked as a critical milestone on the path to a truly comprehensive safer chemical policy for the United States.

  15. Chemical-management policy: prioritizing children's health.

    PubMed

    2011-05-01

    The American Academy of Pediatrics recommends that chemical-management policy in the United States be revised to protect children and pregnant women and to better protect other populations. The Toxic Substance Control Act (TSCA) was passed in 1976. It is widely recognized to have been ineffective in protecting children, pregnant women, and the general population from hazardous chemicals in the marketplace. It does not take into account the special vulnerabilities of children in attempting to protect the population from chemical hazards. Its processes are so cumbersome that in its more than 30 years of existence, the TSCA has been used to regulate only 5 chemicals or chemical classes of the tens of thousands of chemicals that are in commerce. Under the TSCA, chemical companies have no responsibility to perform premarket testing or postmarket follow-up of the products that they produce; in fact, the TSCA contains disincentives for the companies to produce such data. Voluntary programs have been inadequate in resolving problems. Therefore, chemical-management policy needs to be rewritten in the United States. Manufacturers must be responsible for developing information about chemicals before marketing. The US Environmental Protection Agency must have the authority to demand additional safety data about a chemical and to limit or stop the marketing of a chemical when there is a high degree of suspicion that the chemical might be harmful to children, pregnant women, or other populations.

  16. 77 FR 71561 - Health and Safety Data Reporting; Addition of Certain Chemicals

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-03

    ...) of the Toxic Substances Control Act (TSCA) to recommend chemicals and chemical mixtures to EPA for..., any chemical substance or mixture'' to submit lists of health and safety studies conducted or initiated by or for such person with respect to such substance or mixture at any time, known to such...

  17. 76 FR 27294 - Proposed Revocation of the Significant New Use Rule on a Certain Chemical Substance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... Chemical Substance AGENCY: Environmental Protection Agency (EPA). ACTION: Proposed rule. SUMMARY: EPA is... Substances Control Act (TSCA) for a chemical substance identified generically as substituted ethoxyethylamine... new information and test data for the chemical substance and proposes to revoke the SNUR....

  18. 77 FR 76897 - Significant New Use Rule on Certain Chemical Substances; Removal of Significant New Use Rules

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-31

    ... AGENCY 40 CFR Parts 9 and 721 RIN 2070-AB27 Significant New Use Rule on Certain Chemical Substances... Act (TSCA) for four chemical substances which were the subject of premanufacture notices (PMNs). EPA... chemical substances under separate notice and comment procedures. DATES: This final rule is...

  19. 77 FR 43520 - Significant New Use Rules on a Certain Chemical Substance; Removal of Significant New Use Rules

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-25

    ... April 27, 2012 (77 FR 25236), EPA issued several direct final SNURs, including SNURs for five chemical... AGENCY 40 CFR Parts 9 and 721 RIN 2070-AB27 Significant New Use Rules on a Certain Chemical Substance... Act (TSCA) for five chemical substances which were the subject of premanufacture notices (PMNs)....

  20. Federal Register notice: Office of Solid Waste Chemicals; Final Test Rule

    EPA Pesticide Factsheets

    EPA is issuing a final test rule, under section 4 of the Toxic Substances Control Act(TSCA) requiring and/or recommending that manufacturers and processors of 33 chemicals perform testing for human health effects and/or chemical fate.

  1. 40 CFR 710.25 - Chemical substances for which information must be reported.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Chemical substances for which information must be reported. 710.25 Section 710.25 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS 2002 Inventory Update...

  2. 40 CFR 710.45 - Chemical substances for which information must be reported.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Chemical substances for which information must be reported. 710.45 Section 710.45 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS Inventory Update Reporting...

  3. TSCA Section 21 Petition Requesting EPA to Lower Lead Dust Hazard Standards and Modify the Definition of Lead-based Paint in its Regulations

    EPA Pesticide Factsheets

    This petition requests EPA to lower lead dust hazard standards and modify the definition of lead-based paint in its regulations promulgated under sections 401 and 403 of the Toxic Substances Control Act (TSCA).

  4. 77 FR 76419 - Health and Safety Data Reporting; Addition of Certain Chemicals; Withdrawal of Final Rule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-28

    ...-2011-0363; FRL-9375-3] RIN 2070-AJ89 Health and Safety Data Reporting; Addition of Certain Chemicals.... SUMMARY: EPA is withdrawing the final Toxic Substances Control Act (TSCA) section 8(d) Health and Safety Data Reporting Rule that it issued on December 3, 2012. The health and safety data reporting rule...

  5. 40 CFR 799.6784 - TSCA water solubility: Column elution method; shake flask method.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... surface-active materials. (c) Method—(1) Introduction, purpose, scope, relevance, application, and limits... the testing requirements of the Toxic Substances Control Act (TSCA) (15 U.S.C. 2601). (2) Source. The... hydrolysis independence of pH (preliminary test). (2) Coefficient of variation. The coefficient of...

  6. Glossary of CERCLA, RCRA and TSCA related terms and acronyms. Environmental Guidance

    SciTech Connect

    Not Available

    1993-10-01

    This glossary contains CERCLA, RCRA and TSCA related terms that are most often encountered in the US Department of Energy (DOE) Environmental Restoration and Emergency Preparedness activities. Detailed definitions are included for key terms. The CERCLA definitions included in this glossary are taken from the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA), as amended and related federal rulemakings. The RCRA definitions included in this glossary are taken from the Resource Conservation and Recovery Act (RCRA) and related federal rulemakings. The TSCA definitions included in this glossary are taken from the Toxic Substances and Control Act (TSCA) and related federal rulemakings. Definitions related to TSCA are limited to those sections in the statute and regulations concerning PCBs and asbestos.Other sources for definitions include additional federal rulemakings, assorted guidance documents prepared by the US Environmental Protection Agency (EPA), guidance and informational documents prepared by the US Department of Energy (DOE), and DOE Orders. The source of each term is noted beside the term. Terms presented in this document reflect revised and new definitions published before July 1, 1993.

  7. In the arc of history: AIHA and the movement to reform the Toxic Substances Control Act.

    PubMed

    Wilson, Michael P

    2012-01-01

    Dr. Michael P. Wilson of UC Berkeley delivered his keynote address before the general assembly of the American Industrial Hygiene Conference and Exhibition (AIHce) in Portland, Oregon, in May 2011. Here, Dr. Wilson again discusses the political and economic drivers of occupational disease in the United States and proposes a role for AIHA in helping to highlight and resolve them. He proposes that until these underlying drivers are acknowledged and ameliorated, the toll of occupational disease will persist, despite the hard work of industrial hygienists in the workplace. Among these drivers, Dr. Wilson points to the decline of labor rights and unionization; economic inequality; economic insecurity; political resistance to public health protections for workers, notably the OSHA and NIOSH programs; and weaknesses in the Federal Toxic Substances Control Act of 1976 (TSCA). Of these, Dr. Wilson calls on the AIHA to participate in the historic effort to rewrite TSCA. He points to weaknesses in TSCA that have produced a chemicals market dominated by the function, price, and performance of chemicals, with little attention given to their health and environmental effects. Under these conditions, he argues, hazardous chemicals have remained economically competitive, and innovation in inherently safer chemicals-in green chemistry-has been held back by a lack of market transparency and public accountability in the industry. TSCA reform has the potential to shift the market toward green chemistry, with long-term implications for occupational disease prevention, industrial investment, and renewed energy in the industrial hygiene profession. Dr. Wilson proposes that, like previous legislative changes in the United States, TSCA reform is likely to occur in response to myriad social pressures, which include the emergence of the European Union's REACH regulation; recent chemicals policy actions in 18 U.S. states; growing support from downstream businesses; increasing public awareness

  8. 77 FR 75349 - Seventy-First Report of the TSCA Interagency Testing Committee to the Administrator of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... revising the TSCA section 4(e) Priority Testing List by removing 16 High Production Volume (HPV) Challenge... 16 HPV Challenge Program orphan chemicals. B. Status of the Priority Testing List The Priority Testing List includes 16 chemicals with insufficient dermal absorption rate data, 2 alkylphenols, 148...

  9. Chemical Data Reporting

    EPA Pesticide Factsheets

    The Chemical Data Reporting (CDR) site provides information on reporting requirements under TSCA's Chemical Data Reporting Rule. The site provides instruction to data submitters on how to report and enable users to download the reported information.

  10. 40 CFR 799.9380 - TSCA reproduction and fertility effects.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 32 2014-07-01 2014-07-01 false TSCA reproduction and fertility... TESTING REQUIREMENTS Health Effects Test Guidelines § 799.9380 TSCA reproduction and fertility effects. (a... section is for two-generation reproduction testing and is designed to provide general...

  11. 40 CFR 799.9380 - TSCA reproduction and fertility effects.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 32 2011-07-01 2011-07-01 false TSCA reproduction and fertility... TESTING REQUIREMENTS Health Effects Test Guidelines § 799.9380 TSCA reproduction and fertility effects. (a... section is for two-generation reproduction testing and is designed to provide general...

  12. 40 CFR 799.9380 - TSCA reproduction and fertility effects.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 33 2012-07-01 2012-07-01 false TSCA reproduction and fertility... TESTING REQUIREMENTS Health Effects Test Guidelines § 799.9380 TSCA reproduction and fertility effects. (a... section is for two-generation reproduction testing and is designed to provide general...

  13. 40 CFR 799.9380 - TSCA reproduction and fertility effects.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 33 2013-07-01 2013-07-01 false TSCA reproduction and fertility... TESTING REQUIREMENTS Health Effects Test Guidelines § 799.9380 TSCA reproduction and fertility effects. (a... section is for two-generation reproduction testing and is designed to provide general...

  14. Chemical Manufacturing Sector (NAICS 325)

    EPA Pesticide Factsheets

    find EPA regulatory information for the chemical manufacturing sector, including NESHAPs, the SNAP program for ozone depleting substances,effluent guidelines, and new and existing chemicals testing requirements under TSCA.

  15. 78 FR 67142 - HHCB (1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8,-hexamethylcyclopenta[γ]-2-benzopyran) TSCA Risk...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ... panel of scientific experts to conduct a peer review of EPA's draft Toxic Substances Control Act (TSCA... online instructions for submitting comments. Mail: Document Control Office (7407M), Office of Pollution... 20460-0001. Hand Delivery: OPPT Document Control Office (DCO), EPA William Jefferson Clinton...

  16. 40 CFR 799.9120 - TSCA acute dermal toxicity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... source material used in developing this TSCA test guideline is the Office of Prevention, Pesticides, and... known should be determined before the test. Acceptable alternative vehicles include gum arabic,...

  17. 40 CFR 799.9120 - TSCA acute dermal toxicity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... source material used in developing this TSCA test guideline is the Office of Prevention, Pesticides, and... known should be determined before the test. Acceptable alternative vehicles include gum arabic,...

  18. 40 CFR 799.9120 - TSCA acute dermal toxicity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... source material used in developing this TSCA test guideline is the Office of Prevention, Pesticides, and... known should be determined before the test. Acceptable alternative vehicles include gum arabic,...

  19. 40 CFR 799.9120 - TSCA acute dermal toxicity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... source material used in developing this TSCA test guideline is the Office of Prevention, Pesticides, and... known should be determined before the test. Acceptable alternative vehicles include gum arabic,...

  20. Regulating chemicals: law, science, and the unbearable burdens of regulation.

    PubMed

    Silbergeld, Ellen K; Mandrioli, Daniele; Cranor, Carl F

    2015-03-18

    The challenges of regulating industrial chemicals remain unresolved in the United States. The Toxic Substances Control Act (TSCA) of 1976 was the first legislation to extend coverage to the regulation of industrial chemicals, both existing and newly registered. However, decisions related to both law and science that were made in passing this law inevitably rendered it ineffectual. Attempts to fix these shortcomings have not been successful. In light of the European Union's passage of innovative principles and requirements for chemical regulation, it is no longer possible to deny the opportunity and need for reform in US law and practice.

  1. 40 CFR 707.20 - Chemical substances import policy.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... policy, EPA will continue, as necessary, to address problems associated with imports in rulemaking and... insuring that chemical importation complies with TSCA just as domestic manufacturers are responsible for... TSCA.” This is appropriate when a chemical import is not clearly identified as a pesticide or...

  2. 40 CFR 707.20 - Chemical substances import policy.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... policy, EPA will continue, as necessary, to address problems associated with imports in rulemaking and... insuring that chemical importation complies with TSCA just as domestic manufacturers are responsible for... TSCA.” This is appropriate when a chemical import is not clearly identified as a pesticide or...

  3. 40 CFR 707.20 - Chemical substances import policy.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... policy, EPA will continue, as necessary, to address problems associated with imports in rulemaking and... insuring that chemical importation complies with TSCA just as domestic manufacturers are responsible for... TSCA.” This is appropriate when a chemical import is not clearly identified as a pesticide or...

  4. Toxic Substances Control Act Section 8(e): Frequent Questions

    EPA Pesticide Factsheets

    Section 8(e) of the Toxic Substances Control Act (TSCA) requires notification to EPA of information that reasonably supports the conclusion that their substances or mixtures presents a substantial risk of injury to health or the environment.

  5. CERCLA compliance with other laws manual: Summary and Part 2. CAA, TSCA, and other statutes. Fact sheet (Final)

    SciTech Connect

    Not Available

    1990-04-01

    The fact sheet provides a guide to Chapters 2 and 3 of Part II of the CERCLA Compliance With Other Laws Manual. The sixth in a series, this fact sheet focuses on CERCLA compliance with the Clean Air Act (CAA), the Toxic Substances Control Act (TSCA), and the Federal Insecticide, Fungicide, and Rodenticide Act. In addition, it discusses other statutes that set standards for radioactive wastes, mining wastes, and other resource protection statutes that are potential Applicable or Relevant and Appropriate Requirements (ARARs) for CERCLA actions.

  6. Science Advisory Committee on Chemicals Basic Information

    EPA Pesticide Factsheets

    The SACC will provide independent scientific advice and recommendations to the EPA on the scientific basis for risk assessments, methodologies, and pollution prevention measures and approaches for chemicals regulated under the TSCA.

  7. 40 CFR 799.9748 - TSCA metabolism and pharmacokinetics

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... REQUIREMENTS Health Effects Test Guidelines § 799.9748 TSCA metabolism and pharmacokinetics (a) Scope. (1) This... organisms. LOEL is the lowest observable effects level. NOEL is the no observable effects level... used or proposed to be used for the determination of adverse health effects associated with the...

  8. 40 CFR 799.9410 - TSCA chronic toxicity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... clinical abnormalities), gross lesions, identified target organs, body weight changes, effects on mortality... Health Effects Test Guidelines § 799.9410 TSCA chronic toxicity. (a) Scope—(1) Applicability. This... objective of a chronic toxicity study is to determine the effects of a substance in a mammalian...

  9. 40 CFR 799.9748 - TSCA metabolism and pharmacokinetics

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... REQUIREMENTS Health Effects Test Guidelines § 799.9748 TSCA metabolism and pharmacokinetics (a) Scope. (1) This... organisms. LOEL is the lowest observable effects level. NOEL is the no observable effects level... used or proposed to be used for the determination of adverse health effects associated with the...

  10. 40 CFR 799.9410 - TSCA chronic toxicity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... clinical abnormalities), gross lesions, identified target organs, body weight changes, effects on mortality... Health Effects Test Guidelines § 799.9410 TSCA chronic toxicity. (a) Scope—(1) Applicability. This... objective of a chronic toxicity study is to determine the effects of a substance in a mammalian...

  11. Toxic Substances Control Act oversight. Hearings before the Subcommittee on Toxic Substances and Environmental Oversight, United States Senate, Ninety-Eight Congress, first session, July 27, 29, and August 1, 1983

    SciTech Connect

    Not Available

    1984-01-01

    Three days of testimony examined the Toxic Substances Control Act (TSCA) to see if simple reauthorization would be appropriate or if substantive amendments are needed. At issue was whether the structural activity relationship (SAR) process is working in the new chemicals program and whether the triggers for Interagency Testing Committee (ITC) listing are working for existing chemicals. The witnesses included representatives of the Environmental Protection Agency, university laboratories, pesticide and chemical industries, health organizations, citizen groups, and others. Additional material submitted for the record follows the testimony off 18 witnesses and their associates.

  12. Standard Review Risk Assessment on Medium-chain and Long-chain Chlorinated paraffin PMN submissions by Dover Chemical

    EPA Pesticide Factsheets

    This assessment was conducted under EPA’s TSCA Section 5 New Chemicals Program. EPA is assessing Medium-chain Chlorinated Paraffin (MCCP) and Long-Chain Chlorinated Paraffin (LCCP) chemicals as part of its New Chemicals Review program.

  13. TSCA Section 5(b)(4) Concern List

    EPA Pesticide Factsheets

    EPA's existing chemicals programs address pollution prevention, risk assessment, hazard and exposure assessment and/or characterization, and risk management for chemicals substances in commercial use.

  14. 40 CFR 799.9355 - TSCA reproduction/developmental toxicity screening test.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 32 2011-07-01 2011-07-01 false TSCA reproduction/developmental... AND MIXTURE TESTING REQUIREMENTS Health Effects Test Guidelines § 799.9355 TSCA reproduction... reproduction and/or development, either at an early stage of assessing the toxicological properties...

  15. 40 CFR 799.9355 - TSCA reproduction/developmental toxicity screening test.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 33 2013-07-01 2013-07-01 false TSCA reproduction/developmental... AND MIXTURE TESTING REQUIREMENTS Health Effects Test Guidelines § 799.9355 TSCA reproduction... reproduction and/or development, either at an early stage of assessing the toxicological properties...

  16. 40 CFR 799.9355 - TSCA reproduction/developmental toxicity screening test.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 33 2012-07-01 2012-07-01 false TSCA reproduction/developmental... AND MIXTURE TESTING REQUIREMENTS Health Effects Test Guidelines § 799.9355 TSCA reproduction... reproduction and/or development, either at an early stage of assessing the toxicological properties...

  17. 40 CFR 799.9355 - TSCA reproduction/developmental toxicity screening test.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 31 2010-07-01 2010-07-01 true TSCA reproduction/developmental... AND MIXTURE TESTING REQUIREMENTS Health Effects Test Guidelines § 799.9355 TSCA reproduction... reproduction and/or development, either at an early stage of assessing the toxicological properties...

  18. 40 CFR 799.9355 - TSCA reproduction/developmental toxicity screening test.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 32 2014-07-01 2014-07-01 false TSCA reproduction/developmental... AND MIXTURE TESTING REQUIREMENTS Health Effects Test Guidelines § 799.9355 TSCA reproduction... reproduction and/or development, either at an early stage of assessing the toxicological properties...

  19. 40 CFR 799.6786 - TSCA water solubility: Generator column method.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... relatively water soluble are more likely to be widely distributed by the hydrologic cycle than those which... 40 Protection of Environment 31 2010-07-01 2010-07-01 true TSCA water solubility: Generator column... TESTING REQUIREMENTS Product Properties Test Guidelines § 799.6786 TSCA water solubility: Generator...

  20. Identifying new persistent and bioaccumulative organics among chemicals in commerce.

    PubMed

    Howard, Philip H; Muir, Derek C G

    2010-04-01

    The goal of this study was to identify commercial chemicals that might be persistent and bioaccumulative (P&B) and that were not being considered in current Great Lakes, North American, and Arctic contaminant measurement programs. We combined the Canadian Domestic Substance List (DSL), a list of 3059 substances of "unknown or variable composition complex reaction products and biological materials" (UVCBs), and the U.S. Environmental Protection Agency (U.S. EPA) Toxic Substances Control Act (TSCA) Inventory Update Rule (IUR) database for years 1986, 1990, 1994, 1998, 2002, and 2006 yielding a database of 22263 commercial chemicals. From that list, 610 chemicals were identified by estimates from U.S EPA EPISuite software and using expert judgment. This study has yielded some interesting and probable P&B chemicals that should be considered for further study. Recent studies, following up our initial reports and presentations on this work, have confirmed the presence of many of these chemicals in the environment.

  1. 75 FR 47589 - Agency Information Collection Activities; Proposed Collection; Comment Request; Correction of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-06

    ... Misreported Chemical Substances on the TSCA Inventory; EPA ICR No. 1741.06, OMB Control No. 2070-0145 AGENCY... Control Act (TSCA) Inventory and regulated under TSCA section 8, who had reported to the initial effort to... (OMB). This ICR, entitled: ``Correction of Misreported Chemical Substances on the TSCA Inventory''...

  2. Instructions for the 2012 TSCA Chemical Data Reporting

    EPA Pesticide Factsheets

    This document, which pertains to EPA CDR reporting during 2012, updates guidance issued for reporting in 2006 to incorporate instructions relevant to 2012 reporting. It provides detailed information and examples to in reporting under the CDR rule.

  3. TSCA Section 8(e) Reporting Guide

    EPA Pesticide Factsheets

    This reporting guide has been compiled by EPA's Office of Toxic substances (OTS) to assist potential respondents who manufacture, import, process or distribute chemical substances in complying with Section 8(e).

  4. 40 CFR 799.9780 - TSCA immunotoxicity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... quantitative analysis of the effects of a chemical on the numbers of cells in major lymphocyte populations and..., and the research sample shall be stored under conditions that maintain its purity and stability. Prior... type of effect. (ii) All observed results, quantitative and incidental, shall be evaluated by...

  5. 40 CFR 799.9780 - TSCA immunotoxicity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... quantitative analysis of the effects of a chemical on the numbers of cells in major lymphocyte populations and..., and the research sample shall be stored under conditions that maintain its purity and stability. Prior... type of effect. (ii) All observed results, quantitative and incidental, shall be evaluated by...

  6. 40 CFR 799.9780 - TSCA immunotoxicity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... quantitative analysis of the effects of a chemical on the numbers of cells in major lymphocyte populations and..., and the research sample shall be stored under conditions that maintain its purity and stability. Prior... type of effect. (ii) All observed results, quantitative and incidental, shall be evaluated by...

  7. 40 CFR 799.9780 - TSCA immunotoxicity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... quantitative analysis of the effects of a chemical on the numbers of cells in major lymphocyte populations and..., and the research sample shall be stored under conditions that maintain its purity and stability. Prior... type of effect. (ii) All observed results, quantitative and incidental, shall be evaluated by...

  8. TSCA Section 21 Petition Requesting EPA to Regulate Anthropogenic Emissions Carbon Dioxide

    EPA Pesticide Factsheets

    This petition requests EPA to promulgate regulations under section 6 of TSCA to protect “public health and the environment from the serious harms associated with anthropogenic emissions of carbon dioxide, including ocean acidification.

  9. 40 CFR 799.6786 - TSCA water solubility: Generator column method.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... in developing this TSCA test guideline is the Office of Pollution Prevention, Pesticides and Toxics... concentrations of the solute. (B) Alternative method. If another (approved) analytical method is used instead...

  10. 40 CFR 799.6786 - TSCA water solubility: Generator column method.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... in developing this TSCA test guideline is the Office of Pollution Prevention, Pesticides and Toxics... concentrations of the solute. (B) Alternative method. If another (approved) analytical method is used instead...

  11. TSCA Section 21 Petition Requesting EPA to Regulate Lead in Fishing Tackle

    EPA Pesticide Factsheets

    This petition requests EPA to promulgate regulations under section 6 of TSCA to protect the environment from fishing tackle containing lead including fishing weights, sinkers, lures, jigs, and/or other tackle.

  12. Water and a protic ionic liquid acted as refolding additives for chemically denatured enzymes.

    PubMed

    Attri, Pankaj; Venkatesu, P; Kumar, Anil

    2012-10-07

    In this communication, we present the ability of water and a protic ionic liquid, triethyl ammonium phosphate (TEAP) to act as refolding additives for the urea-induced chemical denaturated state of the two enzymes, α-chymotrypsin and succinylated Con A. We show that the enzymatic activity is regained and in certain circumstances enhanced.

  13. 40 CFR 799.9120 - TSCA acute dermal toxicity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... CONTROL ACT (CONTINUED) IDENTIFICATION OF SPECIFIC CHEMICAL SUBSTANCE AND MIXTURE TESTING REQUIREMENTS... mixtures. In order to minimize the need for animal testing, the Agency encourages the review of existing acute toxicity information on mixtures that are substantially similar to the mixture under...

  14. Evaluation of a Fourier transform infrared continuous emission monitor field test at a TSCA incinerator

    SciTech Connect

    Mao, Z.; Demirgian, J.C.; Reedy, G.

    1994-06-01

    A Fourier transform infrared (FTIR) spectrometer was field tested as a continuous emission monitor (CEM) at the Toxic Substances Control Act (TSCA) incinerator at K-25 in Oak Ridge, Tenn., from August 23 to September 3, 1993. This paper reports results obtained from this field test. The FTIR spectrometer and the long-path cell used for the field test were specially designed and constructed, so that optical alignment of the system can be easily performed in the field. The system was tested in the laboratory and then in the field for instrument stability and signal-to-noise ratio. Time interval required for taking a new background spectrum was determined. It appears that the system performs well both in the laboratory and in the field. The field test followed a standard operation procedure (SOP), developed for the test, based on a proposed EPA protocol for applying FTIR in emission testing. Sixteen compounds were selected as target analytes. Ethylene was used as a calibration transfer standard to ensure that spectral performance of the FTIR spectrometer in the field is consistent with that in the laboratory. Spike tests were regularly conducted with a known concentration of a mixture of six compounds and also with SF{sub 6} to check the accuracy of the monitoring system. Data sampling, processing, and reporting were automated to collect data every 10 min, and data were collected throughout the test as long as liquid nitrogen was available in the detector. The instrumentation and software performed flawlessly. Although the field test was a success, further improvement is necessary. Suggestions for revising the SOP and the proposed EPA protocol are discussed.

  15. 40 CFR 799.9310 - TSCA 90-day oral toxicity in rodents.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... target organs, body weight changes, effects on mortality and any other general or specific toxic effects... REQUIREMENTS Health Effects Test Guidelines § 799.9310 TSCA 90-day oral toxicity in rodents. (a) Scope. This... no-observed-effects level (NOEL) and toxic effects associated with continuous or repeated exposure...

  16. 40 CFR 799.9310 - TSCA 90-day oral toxicity in rodents.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... target organs, body weight changes, effects on mortality and any other general or specific toxic effects... REQUIREMENTS Health Effects Test Guidelines § 799.9310 TSCA 90-day oral toxicity in rodents. (a) Scope. This... no-observed-effects level (NOEL) and toxic effects associated with continuous or repeated exposure...

  17. 75 FR 58377 - Lead in Ammunition and Fishing Sinkers; Disposition of TSCA Section 21 Petition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-24

    ... AGENCY Lead in Ammunition and Fishing Sinkers; Disposition of TSCA Section 21 Petition AGENCY... section 6(a) the manufacture, processing, and distribution in commerce of (1) lead bullets and shot; and (2) lead fishing sinkers. On August 27, 2010, EPA denied the first request due to a lack of...

  18. 77 FR 10451 - Fishing Tackle Containing Lead; Disposition of Petition Filed Pursuant to TSCA Section 21

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-22

    ... to discourage the use of fishing tackle containing lead, to raise awareness of lead poisoning in... AGENCY 40 CFR Chapter I Fishing Tackle Containing Lead; Disposition of Petition Filed Pursuant to TSCA... applicable to fishing tackle containing lead (e.g., fishing weights, sinkers, lures, jigs, and/or...

  19. 75 FR 7586 - Baled Natural Rubber in Tires; TSCA Section 21 Petition; Agency Response

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-22

    ... autism.'' After careful consideration, EPA has denied the TSCA section 21 petition for the reasons... allergy induced autism'' (Refs. 1 and 2). This petition is similar to a previous petition that the same...+autism&x=13+y=9 ) dated November 13, 2009, which advertises, and includes an abstract of, a...

  20. 78 FR 48845 - Hydrofluorosilicic Acid in Drinking Water; TSCA Section 21 Petition; Reasons for Agency Response

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-12

    ... AGENCY 40 CFR Chapter I Hydrofluorosilicic Acid in Drinking Water; TSCA Section 21 Petition; Reasons for... to prohibit the use of hydrofluorosilicic acid (HFSA) as a water fluoridation agent. After careful... Regarding the Hydrofluorosilicic Acid (HFSA) in Drinking Water.'' May 9, 2013. 2. Hirzy, J.W.; Carton,...

  1. 40 CFR 710.39 - How do I submit the required information?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS 2002 Inventory Update Reporting § 710.39 How do I... at the following address: OPPT Document Control Officer, Mail Code 7407M, ATTN: Inventory Update Rule... Partial Updating of the TSCA Chemical Inventory Data Base,” via the Internet or the TSCA Hotline....

  2. Request for interim approval to operate Trench 94 of the 218-E-12B Burial Ground as a chemical waste landfill for disposal of polychlorinated biphenyl waste in submarine reactor compartments. Revision 2

    SciTech Connect

    Cummins, G.D.

    1994-06-01

    This request is submitted to seek interim approval to operate a Toxic Substances Control Act (TSCA) of 1976 chemical waste landfill for the disposal of polychlorinated biphenyl (PCB) waste. Operation of a chemical waste landfill for disposal of PCB waste is subject to the TSCA regulations of 40 CFR 761. Interim approval is requested for a period not to exceed 5 years from the date of approval. This request covers only the disposal of small 10 quantities of solid PCB waste contained in decommissioned, defueled submarine reactor compartments (SRC). In addition, the request applies only to disposal 12 of this waste in Trench 94 of the 218-E-12B Burial Ground (Trench 94) in the 13 200 East Area of the US Department of Energy`s (DOE) Hanford Facility. Disposal of this waste will be conducted in accordance with the Compliance 15 Agreement (Appendix H) between the DOE Richland Operations Office (DOE-RL) and 16 the US Environmental Protection Agency (EPA), Region 10. During the 5-year interim approval period, the DOE-RL will submit an application seeking final 18 approval for operation of Trench 94 as a chemical waste landfill, including 19 any necessary waivers, and also will seek a final dangerous waste permit from 20 the Washington State Department of Ecology (Ecology) for disposal of lead 21 shielding contained in the SRCS.

  3. 76 FR 75794 - Significant New Use Rules on Certain Chemical Substances; Withdrawal of Two Chemical Substances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-05

    ... zinc, sodium-doped (PMN P-06-37; CAS No. 389623-07-8). These chemical substances are subject to TSCA..., tin zinc, sodium-doped (PMN P-06-37; CAS No. 389623-07-8) because the Agency received a notice...

  4. 40 CFR 799.6784 - TSCA water solubility: Column elution method; shake flask method.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) IDENTIFICATION OF SPECIFIC CHEMICAL SUBSTANCE... Development (OECD) Laboratory Intercomparison Testing, Part I, 1979, appeared to be dependent on the chemicals... low-soluble chemicals. A general test guideline for the determination of the solubility in water...

  5. 40 CFR 799.6784 - TSCA water solubility: Column elution method; shake flask method.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) IDENTIFICATION OF SPECIFIC CHEMICAL SUBSTANCE... Development (OECD) Laboratory Intercomparison Testing, Part I, 1979, appeared to be dependent on the chemicals... low-soluble chemicals. A general test guideline for the determination of the solubility in water...

  6. 40 CFR 799.6784 - TSCA water solubility: Column elution method; shake flask method.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) IDENTIFICATION OF SPECIFIC CHEMICAL SUBSTANCE... Development (OECD) Laboratory Intercomparison Testing, Part I, 1979, appeared to be dependent on the chemicals... low-soluble chemicals. A general test guideline for the determination of the solubility in water...

  7. 40 CFR 799.6784 - TSCA water solubility: Column elution method; shake flask method.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) IDENTIFICATION OF SPECIFIC CHEMICAL SUBSTANCE... Development (OECD) Laboratory Intercomparison Testing, Part I, 1979, appeared to be dependent on the chemicals... low-soluble chemicals. A general test guideline for the determination of the solubility in water...

  8. Advances in Exposure Science (Washington, DC Modernized TSCA meeting)

    EPA Science Inventory

    I am describing current research from the Chemical Safety for Sustainability research program's Rapid Exposure and Dosimetry project that relates to predicting human exposure to environmental chemicals for thousands of chemicals.

  9. Regulation of Chemicals under Section 6(a) of the Toxic Substances Control Act

    EPA Pesticide Factsheets

    EPA's existing chemicals programs address pollution prevention, risk assessment, hazard and exposure assessment and/or characterization, and risk management for chemicals substances in commercial use.

  10. TSCA Section 9 Relationship to Other Federal Laws

    EPA Pesticide Factsheets

    EPA's existing chemicals programs address pollution prevention, risk assessment, hazard and exposure assessment and/or characterization, and risk management for chemicals substances in commercial use.

  11. Layman's guide to the Toxic Substances Control Act

    SciTech Connect

    Not Available

    1985-04-01

    Contents include: introduction; scope of the law; testing of chemicals; premanufacture and significant new use notifications; control of hazardous chemicals; record keeping and reporting; relationship to other federal laws; research, monitoring, and data systems; exports and imports; disclosure of data; effect on state laws; state programs; judicial review; actions by citizens; employee protection; civil and criminal penalties; enforcement; TSCA assistance office; further information; and EPA regional offices.

  12. History of EPI Suite™ and future perspectives on chemical property estimation in US Toxic Substances Control Act new chemical risk assessments.

    PubMed

    Card, Marcella L; Gomez-Alvarez, Vicente; Lee, Wen-Hsiung; Lynch, David G; Orentas, Nerija S; Lee, Mari Titcombe; Wong, Edmund M; Boethling, Robert S

    2017-03-22

    Chemical property estimation is a key component in many industrial, academic, and regulatory activities, including in the risk assessment associated with the approximately 1000 new chemical pre-manufacture notices the United States Environmental Protection Agency (US EPA) receives annually. The US EPA evaluates fate, exposure and toxicity under the 1976 Toxic Substances Control Act (amended by the 2016 Frank R. Lautenberg Chemical Safety for the 21(st) Century Act), which does not require test data with new chemical applications. Though the submission of data is not required, the US EPA has, over the past 40 years, occasionally received chemical-specific data with pre-manufacture notices. The US EPA has been actively using this and publicly available data to develop and refine predictive computerized models, most of which are housed in EPI Suite™, to estimate chemical properties used in the risk assessment of new chemicals. The US EPA develops and uses models based on (quantitative) structure-activity relationships ([Q]SARs) to estimate critical parameters. As in any evolving field, (Q)SARs have experienced successes, suffered failures, and responded to emerging trends. Correlations of a chemical structure with its properties or biological activity were first demonstrated in the late 19(th) century and today have been encapsulated in a myriad of quantitative and qualitative SARs. The development and proliferation of the personal computer in the late 20(th) century gave rise to a quickly increasing number of property estimation models, and continually improved computing power and connectivity among researchers via the internet are enabling the development of increasingly complex models.

  13. A toxicokinetic study of specifically acting and reactive organic chemicals for the prediction of internal effect concentrations in Scenedesmus vacuolatus.

    PubMed

    Vogs, Carolina; Kühnert, Agnes; Hug, Christine; Küster, Eberhard; Altenburger, Rolf

    2015-01-01

    The toxic potency of chemicals is determined by using the internal effect concentration by accounting for differences in toxicokinetic processes and mechanisms of toxic action. The present study examines toxicokinetics of specifically acting and reactive chemicals in the green algae Scenedesmus vacuolatus by using an indirect method. Concentration depletion in the exposure medium was measured for chemicals of lower (log KOW  < 3: isoproturon, metazachlor, paraquat) and moderate (log KOW 4-5: irgarol, triclosan, N-phenyl-2-naphthylamine) hydrophobicity at 7 to 8 time points over 240 min or 360 min. Uptake and overall elimination rates were estimated by fitting a toxicokinetic model to the observed concentration depletions. The equilibrium of exposure concentrations was reached within minutes to hours or was even not observed within the exposure time. The kinetics of bioconcentration cannot be explained by the chemical's hydrophobicity only, but influential factors such as ionization of chemicals, the ion trapping mechanism, or the potential susceptibility for biotransformation are discussed. Internal effect concentrations associated with 50% inhibition of S. vacuolatus reproduction were predicted by linking the bioconcentration kinetics to the effect concentrations and ranged from 0.0480 mmol/kg wet weight to 7.61 mmol/kg wet weight for specifically acting and reactive chemicals. Knowing the time-course of the internal effect concentration may promote an understanding of toxicity processes such as delayed toxicity, carry-over toxicity, or mixture toxicity in future studies.

  14. Title III list of lists: Consolidated list of chemicals subject to the Emergency Planning and Community Right-to-Know Act (EPCRA) and section 112(r) of the Clean Air Act, as amended. Title III of the Superfund Amendments and Reauthorization Act of 1986, and Title III of the Clean Air Act Amendments of 1990

    SciTech Connect

    Not Available

    1994-06-01

    The consolidated chemical list includes chemicals subject to reporting requirements under Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA), also known as the Emergency Planning and Community Right-to-Know Act (EPCRA), and chemicals listed under section 112(r) of Title III the Clean Air Act (CAA) Amendments of 1990. This consolidated list has been prepared to help firms handling chemicals determine whether they need to submit reports under sections 302, 304, or 313 of SARA Title III (EPCRA) and, for a specific chemical, what reports may need to be submitted. Separate lists are also provided of Resource Conservation and Recovery Act (RCRA) waste streams and unlisted hazardous wastes, and of radionuclides reportable under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). These lists should be used as reference tool, not as a definitive source of compliance information. The chemicals on the consolidated list are ordered by Chemical Abstract Service (CAS) registry number. Categories of chemicals, which do not have CAS registry numbers, but which are cited under CERCLA, EPCRA section 313, and the CAA, are placed at the end of the list. More than one chemical name may be listed for one CAS number, because the same chemical may appear on different lists under different names.

  15. Privacy Impact Assessment for the Confidential Business Information Records Access System for the Toxic Control Substances Act

    EPA Pesticide Factsheets

    This system collects submission data from the Toxic Substances Control Act (TSCA) and contact information for EPA contractors and employees who are CBI cleared. Learn how this data is collected, how it will be used, and the purpose of data collection.

  16. 2008 Toxic Chemical Release Inventory 2008 Toxic Chemical Release Inventory Community Right-to-Know Act of 1986, Title III, Section 313

    SciTech Connect

    Ecology and Air Quality Group

    2009-10-01

    For reporting year 2008, Los Alamos National Laboratory (LANL) submitted a Form R report for lead as required under the Emergency Planning and Community Right-to- Know Act (EPCRA) Section 313. No other EPCRA Section 313 chemicals were used in 2008 above the reportable thresholds. This document was prepared to provide a description of the evaluation of EPCRA Section 313 chemical use and threshold determinations for LANL for calendar year 2008, as well as to provide background information about data included on the Form R reports. Section 313 of EPCRA specifically requires facilities to submit a Toxic Chemical Release Inventory Report (Form R) to the U.S. Environmental Protection Agency (EPA) and state agencies if the owners and operators manufacture, process, or otherwise use any of the listed toxic chemicals above listed threshold quantities. EPA compiles this data in the Toxic Release Inventory database. Form R reports for each chemical over threshold quantities must be submitted on or before July 1 each year and must cover activities that occurred at the facility during the previous year. In 1999, EPA promulgated a final rule on persistent bioaccumulative toxics (PBTs). This rule added several chemicals to the EPCRA Section 313 list of toxic chemicals and established lower reporting thresholds for these and other PBT chemicals that were already reportable. These lower thresholds became applicable in reporting year 2000. In 2001, EPA expanded the PBT rule to include a lower reporting threshold for lead and lead compounds. Facilities that manufacture, process, or otherwise use more than 100 lb of lead or lead compounds must submit a Form R.

  17. Title III List of Lists: Consolidated list of chemicals subject to the Emergency Planning and Community Right-to-Know Act (EPCRA) and Section 112(r) of the Clean Air Act, as amended. Title III of the Superfund Amendments and Reauthorization Act of 1986, and Title III of the Clean Air Act Amendments of 1990

    SciTech Connect

    1996-12-01

    This consolidated chemical list includes chemicals subject to reporting requirements under Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA), also known as the Emergency Planning and Community Right-to-Know Act (EPCRA) and chemicals listed under Section 112(r) of Title III of the Clean Air Act (CAA) Amendments of 1990. This consolidated list has been prepared to help firms handling chemicals determine whether they need to submit reports under sections 302, 304, or 314 or SARA Title III (EPCRA) and, for a specific chemical, what reports may need to be submitted. It also will also help firms determine whether they will be subject to accident prevention regulations under CAA section 112(r).

  18. 1995 Toxic chemical release inventory: Emergency Planning and Community Right-to-Know Act of 1986, Section 313

    SciTech Connect

    Mincey, S.L.

    1996-08-01

    Section 313 of the Emergency Planning and Community Right-To-Know Act (EPCRA) requires the annual submittal of toxic chemical release information to the U.S. Environmental Protection Agency.Executive Order 12856, `Federal Compliance With Right-to-Know Laws and Pollution Prevention Requirements` extends the requirements of EPCRA to all Federal agencies. The following document is the August 1996 submittal of the Hanford Site Toxic Chemical Release Inventory report. Included is a Form R for ethylene glycol, the sole chemical used in excess of the established regulatory thresholds at the Hanford Site by the U.S. Department of Energy, Richland Operations Office and its contractors during Calendar Year 1995.

  19. 75 FR 49655 - TSCA Inventory Update Reporting Modifications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-13

    ... exemptions, to provide a full exemption from IUR requirements for water, and to remove polymers that are... IUR reporting requirements: e.g., polymers, microorganisms, naturally occurring chemical substances... will report in the same manner as is required for organic chemicals, including processing and...

  20. Clean Air Act Standards and Guidelines for Chemical Production and Distribution

    EPA Pesticide Factsheets

    This page contains the stationary sources of air pollution for the chemical production & distribution industries, and their corresponding air pollution regulations. To learn more about the regulations for each industry, just click on the links below.

  1. 75 FR 3462 - Claims of Confidentiality of Certain Chemical Identities Submitted under Section 8(e) of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ... AGENCY Claims of Confidentiality of Certain Chemical Identities Submitted under Section 8(e) of the Toxic... announcing a new general practice of reviewing submissions under section 8(e) of the Toxic Substances Control... section 8(e) of TSCA involves a chemical identity that is already listed on the public portion of the...

  2. 76 FR 65579 - Certain High Production Volume Chemicals; Test Rule and Significant New Use Rule; Fourth Group of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-21

    ... (TSCA) section 4(a)(1)(B) to require manufacturers and processors of 23 high production volume (HPV) chemical substances to develop screening-level health, environmental, and fate data based on the potential... manufacturing and petroleum refineries. Processors of one or more of the subject chemical substances...

  3. 1997 toxic chemical release inventory -- Emergency Planning and Community Right-To-Know Act, Section 313

    SciTech Connect

    Zaloudek, D.E.

    1998-06-30

    Two listed toxic chemicals were used at the Hanford Site above established activity thresholds: phosphoric acid and chlorine. Because total combined quantities of chlorine released, disposed, treated, recovered through recycle operations, co-combusted for energy recovery, and transferred to off-site locations for the purpose of recycle, energy recovery, treatment, and/or disposal, amounted to less than 500 pounds, the Hanford Site qualified for the alternate one million pound threshold for chlorine. Accordingly, this Toxic Chemical Release Inventory includes a Form A for chlorine, and a Form B for phosphoric acid.

  4. 40 CFR 799.9365 - TSCA combined repeated dose toxicity study with the reproduction/developmental toxicity screening...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... study with the reproduction/developmental toxicity screening test. 799.9365 Section 799.9365 Protection... § 799.9365 TSCA combined repeated dose toxicity study with the reproduction/developmental toxicity... all aspects of reproduction and development. In particular, it offers only limited means of...

  5. 40 CFR 799.9365 - TSCA combined repeated dose toxicity study with the reproduction/developmental toxicity screening...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... study with the reproduction/developmental toxicity screening test. 799.9365 Section 799.9365 Protection... § 799.9365 TSCA combined repeated dose toxicity study with the reproduction/developmental toxicity... all aspects of reproduction and development. In particular, it offers only limited means of...

  6. 40 CFR 799.9365 - TSCA combined repeated dose toxicity study with the reproduction/developmental toxicity screening...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... study with the reproduction/developmental toxicity screening test. 799.9365 Section 799.9365 Protection... § 799.9365 TSCA combined repeated dose toxicity study with the reproduction/developmental toxicity... all aspects of reproduction and development. In particular, it offers only limited means of...

  7. 40 CFR 799.9365 - TSCA combined repeated dose toxicity study with the reproduction/developmental toxicity screening...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... study with the reproduction/developmental toxicity screening test. 799.9365 Section 799.9365 Protection... § 799.9365 TSCA combined repeated dose toxicity study with the reproduction/developmental toxicity... all aspects of reproduction and development. In particular, it offers only limited means of...

  8. 40 CFR 799.9365 - TSCA combined repeated dose toxicity study with the reproduction/developmental toxicity screening...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... study with the reproduction/developmental toxicity screening test. 799.9365 Section 799.9365 Protection... § 799.9365 TSCA combined repeated dose toxicity study with the reproduction/developmental toxicity... all aspects of reproduction and development. In particular, it offers only limited means of...

  9. 78 FR 4446 - Exempt Chemical Preparations Under the Controlled Substances Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ... CSA certain compounds, mixtures, or preparations containing a controlled substance, if he finds that such compounds, mixtures, or preparations meet the requirements detailed in 21 U.S.C. 811(g)(3)(B).\\1... Assistant Administrator may exempt a chemical preparation or mixture from the application of...

  10. 40 CFR 799.9539 - TSCA mammalian erythrocyte micronucleus test.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... will be sufficient. Where human exposure to chemicals may be sex-specific, as for example with some... treatment up to 14 days, and 1,000 mg/kg/body weight/day for treatment longer than 14 days. Expected human... considered non-mutagenic in this test. (iii) Although most experiments will give clearly positive or...

  11. 40 CFR 799.9539 - TSCA mammalian erythrocyte micronucleus test.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... will be sufficient. Where human exposure to chemicals may be sex-specific, as for example with some... treatment up to 14 days, and 1,000 mg/kg/body weight/day for treatment longer than 14 days. Expected human... considered non-mutagenic in this test. (iii) Although most experiments will give clearly positive or...

  12. 40 CFR 799.9539 - TSCA mammalian erythrocyte micronucleus test.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... will be sufficient. Where human exposure to chemicals may be sex-specific, as for example with some... treatment up to 14 days, and 1,000 mg/kg/body weight/day for treatment longer than 14 days. Expected human... considered non-mutagenic in this test. (iii) Although most experiments will give clearly positive or...

  13. TSCA Section 21 Petition Requesting EPA to Establish a Process to Amend the List of Natural Sources of Oil and Fat

    EPA Pesticide Factsheets

    This petition requests EPA to to initiate a rulemaking under TSCA Section 83 that would establish a process to amend the list of natural sources of oil and fat in the “Soap and Detergent Association” (SDA) nomenclature system.

  14. 78 FR 27048 - Significant New Use Rules on Certain Chemical Substances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-09

    ... rule includes a PMN substance whose reported chemical name includes the term ``carbon nanotube'' or ``CNT''. Because of a lack of established nomenclature for carbon nanotubes, the TSCA Inventory names for carbon nanotubes are currently in generic form, e.g., carbon nanotube (CNT), multi-walled...

  15. 78 FR 48051 - Significant New Use Rules on Certain Chemical Substances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-07

    ..., whose reported chemical names include the term ``carbon nanotube'' or ``CNT''. Because of a lack of established nomenclature for carbon nanotubes, the TSCA Inventory names for carbon nanotubes are currently in generic form, e.g., carbon nanotube (CNT), multi-walled carbon nanotube (MWCNT), double-walled...

  16. 78 FR 12684 - Proposed Significant New Use Rules on Certain Chemical Substances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-25

    ... reported chemical names include the term ``carbon nanotube'' or ``carbon nanofibers.'' Because of a lack of established nomenclature for carbon nanotubes, the TSCA Inventory names for carbon nanotubes are currently in generic form, e.g., carbon nanotube (CNT), multi-walled carbon nanotube (MWCNT), double-walled...

  17. Act on the Registration and Evaluation of Chemicals (K-REACH) and replacement, reduction or refinement best practices

    PubMed Central

    2016-01-01

    Objectives Korea’s Act on the Registration and Evaluation of Chemicals (K-REACH) was enacted for the protection of human health and the environment in 2015. Considering that about 2000 new substances are introduced annually across the globe, the extent of animal testing requirement could be overwhelming unless regulators and companies work proactively to institute and enforce global best practices to replace, reduce or refine animal use. In this review, the way to reduce the animal use for K-REACH is discussed. Methods Background of the enforcement of the K-REACH and its details was reviewed along with the papers and regulatory documents regarding the limitation of animal experiments and its alternatives in order to discuss the regulatory adoption of alternative tests. Results Depending on the tonnage of the chemical used, the data required ranges from acute and other short-term studies for a single exposure route to testing via multiple exposure routes and costly, longer-term studies such as a full two-generation reproducibility toxicity. The European Registration, Evaluation, Authorization and Restriction of Chemicals regulation provides for mandatory sharing of vertebrate test data to avoid unnecessary duplication of animal use and test costs, and obligation to revise data requirements and test guidelines “as soon as possible” after relevant, validated replacement, reduction or refinement (3R) methods become available. Furthermore, the Organization for Economic Cooperation and Development actively accepts alternative animal tests and 3R to chemical toxicity tests. Conclusions Alternative tests which are more ethical and efficient than animal experiments should be widely used to assess the toxicity of chemicals for K-REACH registration. The relevant regulatory agencies will have to make efforts to actively adopt and uptake new alternative tests and 3R to K-REACH. PMID:28118702

  18. Title III list of lists: Consolidated list of chemicals subject to the Emergency Planning and Community Right-to-Know Act (EPCRA) and section 112(r) of the Clean Air Act, as ammended. Title III of the Superfund Amendments and Reauthorization Act of 1986, and Title III of the Clean Air Act Amendments of 1990, April 1995

    SciTech Connect

    1995-04-01

    This consolidated list has been prepared to help firms handling chemicals determine whether they need to submit reports under sections 302, 304, or 313 of SARA Title III (EPCRA) and, for a specific chemical, what reports may need to be submitted. It will also help firms determine whether they will be subject to accident prevention regulations under CAA section 112(r). Separate lists are also provided of Resource Conservation and Recovery Act (RCRA) waste streams and unlisted hazardous wastes, and of radionuclides reportable under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). These lists should be used as a reference tool, not as a definitive source of compliance information.

  19. Recovery Act: Novel Oxygen Carriers for Coal-fueled Chemical Looping

    SciTech Connect

    Pan, Wei-Ping; Cao, Yan

    2012-11-30

    Chemical Looping Combustion (CLC) could totally negate the necessity of pure oxygen by using oxygen carriers for purification of CO{sub 2} stream during combustion. It splits the single fuel combustion reaction into two linked reactions using oxygen carriers. The two linked reactions are the oxidation of oxygen carriers in the air reactor using air, and the reduction of oxygen carriers in the fuel reactor using fuels (i.e. coal). Generally metal/metal oxides are used as oxygen carriers and operated in a cyclic mode. Chemical looping combustion significantly improves the energy conversion efficiency, in terms of the electricity generation, because it improves the reversibility of the fuel combustion process through two linked parallel processes, compared to the conventional combustion process, which is operated far away from its thermo-equilibrium. Under the current carbon-constraint environment, it has been a promising carbon capture technology in terms of fuel combustion for power generation. Its disadvantage is that it is less mature in terms of technological commercialization. In this DOE-funded project, accomplishment is made by developing a series of advanced copper-based oxygen carriers, with properties of the higher oxygen-transfer capability, a favorable thermodynamics to generate high purity of CO{sub 2}, the higher reactivity, the attrition-resistance, the thermal stability in red-ox cycles and the achievement of the auto-thermal heat balance. This will be achieved into three phases in three consecutive years. The selected oxygen carriers with final-determined formula were tested in a scaled-up 10kW coal-fueled chemical looping combustion facility. This scaled-up evaluation tests (2-day, 8-hour per day) indicated that, there was no tendency of agglomeration of copper-based oxygen carriers. Only trace-amount of coke or carbon deposits on the copper-based oxygen carriers in the fuel reactor. There was also no evidence to show the sulphidization of oxygen

  20. Consolidated list of chemicals subject to reporting under the Emergency Planning and Community Right-to-Know Act. (Title III of the Superfund Amendments and Reauthorization Act of 1986)

    SciTech Connect

    Not Available

    1992-01-01

    The consolidated chemical list includes chemicals subject to reporting requirements under Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA), also known as the Emergency Planning and Community Right-to-Know Act (EPCRA). It has been prepared to help firms handling chemicals determine whether they need to submit reports under sections 302, 304, or 313 of Title III and, for a specific chemical, what reports may need to be submitted. Separate lists are also provided of RCRA waste streams and unlisted hazardous wastes, and of radionuclides reportable under CERCLA. The lists should be used as a reference tool, not as a definitive source of compliance information. Compliance information is published in the Code of Federal Regulations, 40 CFR Parts 302, 355, and 372. The chemicals on the consolidated list are ordered by Chemical Abstract Service (CAS) registry number. Categories of chemicals, which do not have CAS registry numbers, but which are cited under CERCLA and section 313, are placed at the end of the list. For reference purposes, the chemicals (with their CAS numbers) are ordered alphabetically following the CAS-order list. Long chemical names may have been truncated to facilitate printing of the list.

  1. Consolidated list of chemicals subject to reporting under the Emergency Planning and Community Right-To-Know Act: SARA (Superfund Amendments and Reauthorization Act of 1986) Section 302 Extremely Hazardous Substances, CERCLA (Comprehensive Environmental Response, Compensation, and Liability Act) Hazardous Substances and SARA Section 313 Toxic Chemicals (Title III. List of Lists) (for microcomputers). Data file

    SciTech Connect

    Sykes, H.

    1990-01-01

    The data file is the disk-based version of the Office of Toxic Substances' consolidated list of chemicals subject to reporting under Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA) and SARA Section 302 Extremely Hazardous Substances, as well as CERCLA Hazardous Substances. Title III is also known as the Emergency Planning and Community Right to Know Act. The disks are designed to generate either a printout or a dBase III file from any IBM or IBM compatible system.

  2. 78 FR 59679 - Antimony Trioxide TSCA Chemical Risk Assessment; Notice of Public Meetings and Opportunity To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-27

    ..., unless the comment includes information claimed to be Confidential Business Information (CBI) or other... provide it in the body of your comment. If you send an email comment directly to EPA without going through... recommends that you include your name and other contact information in the body of your comment and with...

  3. Predictive Models and Tools for Screening Chemicals under TSCA: Consumer Exposure Models 1.5

    EPA Pesticide Factsheets

    CEM contains a combination of models and default parameters which are used to estimate inhalation, dermal, and oral exposures to consumer products and articles for a wide variety of product and article use categories.

  4. 78 FR 64936 - Dichloromethane and N-Methylpyrrolidone TSCA Chemical Risk Assessment; Notice of Rescheduled...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-30

    ...). ACTION: Notice. SUMMARY: On August 23, 2013, EPA announced that it would be holding three peer review.... Due to the government shutdown, however, EPA has rescheduled the remaining two peer review meetings... public comments. DATES: Meetings. The peer review meetings will be held on Friday, November 8, 2013,...

  5. 75 FR 8266 - Final Clarification for Chemical Identification Describing Activated Phosphors for TSCA Inventory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... manufacturer submitted a Low Volume Exemption (LVE) Application for an activated phosphor with a letter..., no submission should be necessary, but the Agency did accept the application and granted the LVE... applications must have done so at least 90 days (for PMNs, less for exemption applications) before...

  6. TSCA Work Plan Chemical Risk Assessment N-Methylpyrrolidone: Paint Stripper Use

    EPA Pesticide Factsheets

    This final assessment for N-Methylpyrrolidone identified acute and chronic health risks to people, particularly pregnant women and women of childbearing age, who who are exposed to paint and coating removal products containing high concentrations of NMP.

  7. Instructions for Reporting for the 2006 Partial Updating of the TSCA Chemical Inventory Database

    EPA Pesticide Factsheets

    The primary goal of this document is to help the regulated community comply with the requirements of the IUR regulations. This document does not substitute for those regulations, nor is it a regulation itself.

  8. 78 FR 52525 - Dichloromethane and N-Methylpyrrolidone TSCA Chemical Risk Assessment; Notice of Public Meetings...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ... review panel members will have access to written comments and materials and electronic materials... distribute any written comments or materials or electronic materials directly to the peer review panel... meetings, as well as written comments and materials and electronic materials in the docket at...

  9. 78 FR 34377 - Trichloroethylene TSCA Chemical Risk Assessment; Notice of Public Meetings and Opportunity to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-07

    .... Comments. Written comments and materials and electronic materials must be submitted on or before July 23... copy form. Publicly available docket materials are available either in the electronic docket at http... written comments and materials and electronic materials submitted to the docket by July 23,...

  10. 78 FR 67141 - Antimony Trioxide (ATO) TSCA Chemical Risk Assessment; Notice of Public Meetings and Opportunity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ... To Comment AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: On September 27... Pollution Prevention and Toxics, Environmental Protection Agency, 1200 Pennsylvania Ave. NW., Washington, DC... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL...

  11. Results of Hazardous and Mixed Waste Excavation from the Chemical Waste Landfill

    SciTech Connect

    Young, S. G.; Schofield, D. P.; Kwiecinski, D.; Edgmon, C. L.; Methvin, R.

    2002-02-27

    This paper describes the results of the excavation of a 1.9-acre hazardous and mixed waste landfill operated for 23 years at Sandia National Laboratories, Albuquerque, New Mexico. Excavation of the landfill was completed in 2 1/2 years without a single serious accident or injury. Approximately 50,000 cubic yards of soil contaminated with volatile and semi-volatile organics, metals, polychlorinated biphenyl compounds, and radioactive constituents was removed. In addition, over 400 cubic yards of buried debris was removed, including bulk debris, unknown chemicals, compressed gas cylinders, thermal and chemical batteries, explosive and ordnance debris, pyrophoric materials and biohazardous waste. Removal of these wastes included negotiation of multiple regulations and guidances encompassed in the Resource Conservation and Recovery Act (RCRA), the Toxic Substances Control Act (TSCA), and risk assessment methodology. RCRA concepts that were addressed include the area of contamination, permit modification, emergency treatment provision, and listed waste designation. These regulatory decisions enabled the project to overcome logistical and programmatic needs such as increased operational area, the ability to implement process improvements while maintaining a record of decisions and approvals.

  12. 1997 Toxic Chemical Release Inventory Report for the Emergency Planning and Community Right-to-Know Act of 1986, Title III, Section 313

    SciTech Connect

    Heather McBride

    1997-07-01

    The Emergency Planning and Community Right-to-Know Act of 1986 (EPCIL4), Title III, Section 313 [also known as the Superfund Amendment and Reauthorization Act (SARA)], as modified by Executive Order 12856, requires all federal facilities to submit an annual Toxic Chemical Release Inventory report every July for the preceding calendar year. Owners and operators of manufacturing, processing, or production facilities are required to report their toxic chemical releases to all environmental mediums (air, water, soil, etc.). At Los Alamos National Laboratory (LANL), nitric acid was the only toxic chemical used in 1997 that met the reportable threshold limit of 10,000 lb. Form R is the only documentation required by the Environmental Protection Agency, and it is included in the appendix of this report. This report, as requested by DOE, is provided for documentation purposes. In addition, a detailed description of the evaluation and reporting process for chemicals and processes at LANL has been included.

  13. Chemical Safety Improvement Act

    THOMAS, 113th Congress

    Sen. Lautenberg, Frank R. [D-NJ

    2013-05-22

    02/04/2014 Committee on Environment and Public Works Subcommittee on Water and Wildlife. Hearings held. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  14. Secure Chemical Facilities Act

    THOMAS, 111th Congress

    Sen. Lautenberg, Frank R. [D-NJ

    2010-07-15

    07/15/2010 Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  15. Secure Chemical Facilities Act

    THOMAS, 112th Congress

    Sen. Lautenberg, Frank R. [D-NJ

    2011-03-31

    03/31/2011 Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  16. Secure Chemical Facilities Act

    THOMAS, 113th Congress

    Sen. Lautenberg, Frank R. [D-NJ

    2013-01-23

    01/23/2013 Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  17. 1998 Toxic Chemical Release Inventory Report for the Emergency Planning and Community Right-to-Know Act of 1986, Title III

    SciTech Connect

    Marjorie B. Stockton

    1999-11-01

    The Emergency Planning and Community Right-to-Know Act (EPCRA) of 1986 [also known as the Superfund Amendment and Reauthorization Act (SARA), Title III], as modified by Executive Order 12856, requires that all federal facilities evaluate the need to submit an annual Toxic Chemical Release Inventory report as prescribed in Title III, Section 313 of this Act. This annual report is due every July for the preceding calendar year. Owners and operators who manufacture, process, or otherwise use certain toxic chemicals above listed threshold quantities are required to report their toxic chemical releases to all environmental mediums (air, water, soil, etc.). At Los Alamos National Laboratory (LANL), no EPCRA Section 313 chemicals were used in 1998 above the reportable threshold limits of 10,000 lb or 25,000 lb. Therefore LANL was not required to submit any Toxic Chemical Release Inventory reports (Form Rs) for 1998. This document was prepared to provide a detailed description of the evaluation on chemical usage and EPCRA Section 313 threshold determinations for LANL for 1998.

  18. Introduction to ChemView

    EPA Pesticide Factsheets

    EPA's Existing Chemicals program addresses pollution prevention, risk assessment, and risk management for chemicals in commercial use under the authority of the Toxic Substances Control Act (TSCA) and the Pollution Prevention Act (PPA)

  19. Cheminformatics Applications and Physicochemical Property Calculators: A Powerful Combination for the Encoding of Process Science

    EPA Science Inventory

    The registration of new chemicals under the Toxic Substances Control Act (TSCA) and new pesticides under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) requires knowledge of the process science underlying the transport and transformation of organic chemicals in n...

  20. Cheminformatics and Computational Chemistry: A Powerful Combination for the Encoding of Process Science

    EPA Science Inventory

    The registration of new chemicals under the Toxicological Substances Control Act (TSCA) and new pesticides under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) requires knowledge of the process science underlying the transformation of organic chemicals in natural...

  1. Use of QSAR validation principles to enhance predictive approaches in the US EPA ECOSAR model

    EPA Science Inventory

    The US EPA Office of Pollution Prevention and Toxics (OPPT) is responsible for implementing the Toxic Substances Control Act (TSCA). TSCA is the US law that regulates industrial chemicals in the US and OPPT evaluates both new chemicals entering commerce, as well as those chemica...

  2. 40 CFR 710.59 - Availability of reporting form and instructions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS Inventory Update Reporting for 2006 and Beyond... for the 2006 Partial Updating of the TSCA Chemical Inventory Database,” are available as described in... website. Go to the EPA Inventory Update Reporting Internet home page at http://www.epa.gov/oppt/iur...

  3. 1992 Tier Two emergency and hazardous chemical inventory. Emergency Planning and Community Right-To-Know Act, Section 312

    SciTech Connect

    Not Available

    1993-03-01

    This report is a compilation of data on emergency and hazardous chemicals stored at the Hanford Reservation. The report lists name or chemical description, physical and health hazards, inventories and storage location.

  4. 2009 Toxic Chemical Release Inventory Report for the Emergency Planning and Community Right-to-Know Act of 1986, Title III, Section 313

    SciTech Connect

    Environmental Stewardship Group

    2010-11-01

    For reporting year 2009, Los Alamos National Laboratory (LANL) submitted a Form R report for lead as required under the Emergency Planning and Community Right-to- Know Act (EPCRA) Section 313. No other EPCRA Section 313 chemicals were used in 2009 above the reportable thresholds. This document was prepared to provide a description of the evaluation of EPCRA Section 313 chemical use and threshold determinations for LANL for calendar year 2009, as well as to provide background information about data included on the Form R reports.

  5. Pollution prevention opportunity assessment for the K-25 Site Toxic Substances Control Act Incinerator Operations, Level III

    SciTech Connect

    1995-09-01

    A Level III pollution prevention opportunity assessment (PPOA) was performed for the Oak Ridge K-25 Site Toxic Substances Control Act (TSCA) Incinerator to evaluate pollution prevention (P2) options for various waste streams: The main objective of this study was to identify and evaluate options to reduce the quantities of each waste stream generated by the TSCA Incinerator operations to realize significant environmental and/or economic benefits from P2. For each of the waste streams, P2 options were evaluated following the US Environmental Protection Agency (EPA) hierarchy to (1) reduce the quantity of waste generated, (2) recycle the waste, and/or (3) use alternate waste treatment or segregation methods. This report provides process descriptions, identification and evaluation of P2 options, and final recommendations.

  6. National Emission Standard for Hazardous Air Pollutants compliance verification plan for the K-1435 Toxic Substances Control Act Incinerator

    SciTech Connect

    Ambrose, M.L.

    1986-07-28

    This documentation was prepared for submittal to the Environmental Protection Agency (EPA) in order to meet the requirements of the National Emissions Standards for Hazardous Air Pollutants (NESHAP). This document will emphasize the control of radioactive emissions from the K-1435 Toxic Substances Control Act (TSCA) Incinerator. The TSCA Incinerator is a dual purpose solid/liquid incinerator that is under construction at the Oak Ridge Gaseous Diffusion Plant to destroy radioactively contaminated polychlorinated biphenyls (PCBs) and other hazardous organic wastes in compliance with the TSCA and the Resource Conservation and Recovery Act (RCRA). These wastes are generated at the facilities managed by the Department of Energy, Oak Ridge Operations (DOE-ORO). Destruction of the PCBs and the hazardous organic wastes will be accomplished in a rotary kiln incinerator with an afterburner. The incinerator will thermally destroy the organic constituents of the liquids, solids, and sludges to produce an organically inert ash. In addition to the incinerator, an extensive off-gas treatment facility is being constructed to remove particulate and acidic gas air emissions.

  7. Framework for identifying chemicals with structural features associated with the potential to act as developmental or reproductive toxicants.

    PubMed

    Wu, Shengde; Fisher, Joan; Naciff, Jorge; Laufersweiler, Michael; Lester, Cathy; Daston, George; Blackburn, Karen

    2013-12-16

    Developmental and reproductive toxicity (DART) end points are important hazard end points that need to be addressed in the risk assessment of chemicals to determine whether or not they are the critical effects in the overall risk assessment. These hazard end points are difficult to predict using current in silico tools because of the diversity of mechanisms of action that elicit DART effects and the potential for narrow windows of vulnerability. DART end points have been projected to consume the majority of animals used for compliance with REACH; thus, additional nonanimal predictive tools are urgently needed. This article presents an empirically based decision tree for determining whether or not a chemical has receptor-binding properties and structural features that are consistent with chemical structures known to have toxicity for DART end points. The decision tree is based on a detailed review of 716 chemicals (664 positive, 16 negative, and 36 with insufficient data) that have DART end-point data and are grouped into defined receptor binding and chemical domains. When tested against a group of chemicals not included in the training set, the decision tree is shown to identify a high percentage of chemicals with known DART effects. It is proposed that this decision tree could be used both as a component of a screening system to identify chemicals of potential concern and as a component of weight-of-evidence decisions based on structure-activity relationships (SAR) to fill data gaps without generating additional test data. In addition, the chemical groupings generated could be used as a starting point for the development of hypotheses for in vitro testing to elucidate mode of action and ultimately in the development of refined SAR principles for DART that incorporate mode of action (adverse outcome pathways).

  8. 2006 Toxic Chemical Release Inventory Report for the Emergency Planning and Community Right-to-Know Act of 1986, Title III, Section 313

    SciTech Connect

    Ecology and Air Quality Group

    2007-12-12

    For reporting year 2006, Los Alamos National Laboratory (LANL or the Laboratory) submitted Form R reports for lead as required under the Emergency Planning and Community Right-to-Know Act (EPCRA) Section 313. No other EPCRA Section 313 chemicals were used in 2006 above the reportable thresholds. This document was prepared to provide a description of the evaluation of EPCRA Section 313 chemical use and threshold determinations for LANL for calendar year 2006, as well as to provide background information about data included on the Form R reports. Section 313 of EPCRA specifically requires facilities to submit a Toxic Chemical Release Inventory Report (Form R) to the U.S. Environmental Protection Agency (EPA) and state agencies if the owners and operators manufacture, process, or otherwise use any of the listed toxic chemicals above listed threshold quantities. EPA compiles this data in the Toxic Release Inventory database. Form R reports for each chemical over threshold quantities must be submitted on or before July 1 each year and must cover activities that occurred at the facility during the previous year. In 1999, EPA promulgated a final rule on persistent bioaccumulative toxics (PBTs). This rule added several chemicals to the EPCRA Section 313 list of toxic chemicals and established lower reporting thresholds for these and other PBT chemicals that were already reportable. These lower thresholds became applicable in reporting year 2000. In 2001, EPA expanded the PBT rule to include a lower reporting threshold for lead and lead compounds. Facilities that manufacture, process, or otherwise use more than 100 lb of lead or lead compounds must submit a Form R.

  9. In silico identification and pharmacological evaluation of novel endocrine disrupting chemicals that act via the ligand-binding domain of the estrogen receptor α.

    PubMed

    McRobb, Fiona M; Kufareva, Irina; Abagyan, Ruben

    2014-09-01

    Endocrine disrupting chemicals (EDCs) pose a significant threat to human health, society, and the environment. Many EDCs elicit their toxic effects through nuclear hormone receptors, like the estrogen receptor α (ERα). In silico models can be used to prioritize chemicals for toxicological evaluation to reduce the amount of costly pharmacological testing and enable early alerts for newly designed compounds. However, many of the current computational models are overly dependent on the chemistry of known modulators and perform poorly for novel chemical scaffolds. Herein we describe the development of computational, three-dimensional multi-conformational pocket-field docking, and chemical-field docking models for the identification of novel EDCs that act via the ligand-binding domain of ERα. These models were highly accurate in the retrospective task of distinguishing known high-affinity ERα modulators from inactive or decoy molecules, with minimal training. To illustrate the utility of the models in prospective in silico compound screening, we screened a database of over 6000 environmental chemicals and evaluated the 24 top-ranked hits in an ERα transcriptional activation assay and a differential scanning fluorimetry-based ERα binding assay. Promisingly, six chemicals displayed ERα agonist activity (32nM-3.98μM) and two chemicals had moderately stabilizing effects on ERα. Two newly identified active compounds were chemically related β-adrenergic receptor (βAR) agonists, dobutamine, and ractopamine (a feed additive that promotes leanness in cattle and poultry), which are the first βAR agonists identified as activators of ERα-mediated gene transcription. This approach can be applied to other receptors implicated in endocrine disruption.

  10. In Silico Identification and Pharmacological Evaluation of Novel Endocrine Disrupting Chemicals That Act via the Ligand-Binding Domain of the Estrogen Receptor α

    PubMed Central

    Kufareva, Irina; Abagyan, Ruben

    2014-01-01

    Endocrine disrupting chemicals (EDCs) pose a significant threat to human health, society, and the environment. Many EDCs elicit their toxic effects through nuclear hormone receptors, like the estrogen receptor α (ERα). In silico models can be used to prioritize chemicals for toxicological evaluation to reduce the amount of costly pharmacological testing and enable early alerts for newly designed compounds. However, many of the current computational models are overly dependent on the chemistry of known modulators and perform poorly for novel chemical scaffolds. Herein we describe the development of computational, three-dimensional multi-conformational pocket-field docking, and chemical-field docking models for the identification of novel EDCs that act via the ligand-binding domain of ERα. These models were highly accurate in the retrospective task of distinguishing known high-affinity ERα modulators from inactive or decoy molecules, with minimal training. To illustrate the utility of the models in prospective in silico compound screening, we screened a database of over 6000 environmental chemicals and evaluated the 24 top-ranked hits in an ERα transcriptional activation assay and a differential scanning fluorimetry-based ERα binding assay. Promisingly, six chemicals displayed ERα agonist activity (32nM–3.98μM) and two chemicals had moderately stabilizing effects on ERα. Two newly identified active compounds were chemically related β-adrenergic receptor (βAR) agonists, dobutamine, and ractopamine (a feed additive that promotes leanness in cattle and poultry), which are the first βAR agonists identified as activators of ERα-mediated gene transcription. This approach can be applied to other receptors implicated in endocrine disruption. PMID:24928891

  11. 2002 Toxic Chemical Release Inventory Report for the Emergency Planning and Community Right-to-Know Act of 1986, Title III, Section 313

    SciTech Connect

    M. Stockton

    2003-11-01

    For reporting year 2002, Los Alamos National Laboratory (LANL or the Laboratory) submitted Form R reports for lead compounds and mercury as required under the Emergency Planning and Community Right-to-Know Act (EPCRA), Section 313. No other EPCRA Section 313 chemicals were used in 2002 above the reportable thresholds. This document was prepared to provide a description of the evaluation of EPCRA Section 313 chemical usage and threshold determinations for LANL for calendar year 2002 as well as provide background information about the data included on the Form R reports. Section 313 of EPCRA specifically requires facilities to submit a Toxic Chemical Release Inventory report (Form R) to the U.S. Environmental Protection Agency (EPA) and state agencies if the owners and operators manufacture, process, or otherwise use any of the listed toxic chemicals above listed threshold quantities. EPA compiles this data in the Toxic Release Inventory database. Form R reports for each chemical over threshold quantities must be submitted on or before July 1 each year and must cover activities that occurred at the facility during the previous year. In 1999 EPA promulgated a final rule on Persistent Bioaccumulative Toxics (PBTs). This rule added several chemicals to the EPCRA Section 313 list of toxic chemicals and established lower reporting thresholds for these and other PBT chemicals that were already reportable under EPCRA Section 313. These lower thresholds became applicable in reporting year 2000. In 2001, EPA expanded the PBT rule to include a lower reporting threshold for lead and lead compounds. Facilities that manufacture, process, or otherwise use more than 100 lb of lead or lead compounds must submit a Form R.

  12. FY2016 Enforcement Actions for the Lead Renovation, Repair and Painting Rule (RRP)

    EPA Pesticide Factsheets

    The Toxic Substances Control Act (TSCA) New and Existing Chemicals (NEC) Program is exclusively a federal program that provides for review of the risk of chemicals prior to their manufacture and importation to prevent unreasonable risk to human health

  13. 2004 Toxic Chemical Release Inventory Report for the Emergency Planning and Community Right-to-Know Act of 1986, Title III, Section 313

    SciTech Connect

    M. Stockton

    2006-01-15

    Section 313 of Emergency Planning and Community Right-to-Know Act (EPCRA) specifically requires facilities to submit a Toxic Chemical Release Inventory Report (Form R) to the U.S. Environmental Protection Agency (EPA) and state agencies if the owners and operators manufacture, process, or otherwise use any of the listed toxic chemicals above listed threshold quantities. EPA compiles this data in the Toxic Release Inventory database. Form R reports for each chemical over threshold quantities must be submitted on or before July 1 each year and must cover activities that occurred at the facility during the previous year. For reporting year 2004, Los Alamos National Laboratory (LANL or the Laboratory) submitted Form R reports for lead compounds, nitric acid, and nitrate compounds as required under the EPCRA Section 313. No other EPCRA Section 313 chemicals were used in 2004 above the reportable thresholds. This document provides a description of the evaluation of EPCRA Section 313 chemical use and threshold determinations for LANL for calendar year 2004, as well as background information about data included on the Form R reports.

  14. Chemical Conjugation of Evans Blue Derivative: A Strategy to Develop Long-Acting Therapeutics through Albumin Binding

    PubMed Central

    Chen, Haojun; Wang, Guohao; Lang, Lixin; Jacobson, Orit; Kiesewetter, Dale O.; Liu, Yi; Ma, Ying; Zhang, Xianzhong; Wu, Hua; Zhu, Lei; Niu, Gang; Chen, Xiaoyuan

    2016-01-01

    The efficacy of therapeutic drugs is highly dependent on their optimal in vivo pharmacokinetics. Albumin conjugation is considered to be one of the most effective means of protracting the short lifespan of peptides and proteins. In this study, we proposed a novel platform for developing long lasting therapeutics by conjugating a small molecular albumin binding moiety, truncated Evans blue, to either peptides or proteins. Using the anti-diabetic peptide drug Exendin-4 as a model peptide, we synthesized a new long-acting Exendin-4 derivative (denoted as Abextide). Through complexation with albumin in situ, the biological half-life of Abextide was significantly extended. The hypoglycemic effect of Abextide was also improved remarkably over Exendin-4. Thus, Abextide has considerable potential to treat type 2 diabetes. This strategy as a general technology platform can be applied to other small molecules and biologics for the development of long-acting therapeutic drugs. PMID:26877782

  15. Environmental implementation plan: Chapter 5, Chemical management, pollution prevention and other compliance programs. Draft revision

    SciTech Connect

    Peterson, G.L.

    1993-11-18

    Compliance with environmental regulations and US Department of Energy Orders (DOE) relating to environmental protection is an important part of SRS`s program. Over the past few years, the number of environmental regulations has increased. The strategy to comply with new and existing environmental regulations and DOE orders is described in chapter two. In this chapter, the following environmental programs are described: Toxic Substances Control Act (TSCA); Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA); Emergency Planning and Community Right-to-Know Act (EPCRA); and SPCC/BMP/Pollution Prevention Plans;The implementation section identifies issues and those responsible to achieve defined objectives.

  16. Hanford 1999 Tier 2 Emergency and Hazardous Chemical Inventory Emergency Planning and Community Right to Know Act Section 312

    SciTech Connect

    ZALOUDEK, D.E.

    2000-03-01

    The Hanford Site covers approximately 1,450 square kilometers (560 square miles) of land that is owned by the U.S. Government and managed by the U.S. Department of Energy, Richland Operations Office (DOE-RL). The Hanford Site is located northwest of the city of Richland, Washington. The city of Richland adjoins the southeastern portion of the Hanford Site boundary and is the nearest population center. Activities on the Hanford Site are centralized in numerically designated areas. The 100 Areas, located along the Columbia River, contain deactivated reactors. The processing units are in the 200 Areas, which are on a plateau approximately 11 kilometers (7 miles) from the Columbia River. The 300 Area, located adjacent to and north of Richland, contains research and development laboratories. The 400 Area, 8 kilometers (5 miles) northwest of the 300 Area, contains the Fast Flux Test Facility previously used for testing liquid metal reactor systems. Adjacent to the north of Richland, the 1100 Area contains offices associated with administration, maintenance, transportation, and materials procurement and distribution. The 600 Area covers all locations not specifically given an area designation. This Tier Two Emergency and Hazardous Chemical Inventory report contains information pertaining to hazardous chemicals managed by DOE-RL and its contractors on the Hanford Site. It does not include chemicals maintained in support of activities conducted by others on lands covered by leases, use permits, easements, and other agreements whereby land is used by parties other than DOE-RL. For example, this report does not include chemicals stored on state owned or leased lands (including the burial ground operated by US Ecology, Inc.), lands owned or used by the Bonneville Power Administration (including the Midway Substation and the Ashe Substation), lands used by the National Science Foundation (the Laser Interferometer Gravitational-Wave Observatory), lands leased to the Washington

  17. 1998 Tier two emergency and hazardous chemical inventory - emergency planning and community right-to-know act section 312

    SciTech Connect

    ZALOUDEK, D.E.

    1999-03-02

    The Hanford Site covers approximately 1,450 square kilometers (560 square miles) of land that is owned by the U.S, Government and managed by the U.S. Department of Energy, Richland Operations Office (DOE-RL). The Hanford Site is located northwest of the city of Richland, Washington. The city of Richland adjoins the southeastern portion of the Hanford Site boundary and is the nearest population center. Activities on the Hanford Site are centralized in numerically designated areas. The 100 Areas, located along the Columbia River, contain deactivated reactors. The processing units are in the 200 Areas, which are on a plateau approximately 11 kilometers (7 miles) from the Columbia River. The 300 Area, located adjacent to and north of Richland, contains research and development laboratories. The 400 Area, 8 kilometers (5 miles) northwest of the 300 Area, contains the Fast Flux Test Facility previously used for testing liquid metal reactor systems. Adjacent to the north of Richland, the 1100 Area contains offices associated with administration, maintenance, transportation, and materials procurement and distribution. The 600 Area covers all locations not specifically given an area designation. This Tier Two Emergency and Hazardous Chemical Inventory report contains information pertaining to hazardous chemicals managed by DOE-RL and its contractors on the Hanford Site. It does not include chemicals maintained in support of activities conducted by others on lands covered by leases, use permits, easements, and other agreements whereby land is used by parties other than DOE-RL. For example, this report does not include chemicals stored on state owned or leased lands (including the burial ground operated by US Ecology, Inc.), lands owned or used by the Bonneville Power Administration (including the Midway Substation and the Ashe Substation), lands used by the National Science Foundation (the Laser Interferometer Gravitational-Wave Observatory), lands leased to the Washington

  18. Population growth rate responses of Ceriodaphnia dubia to ternary mixtures of specific acting chemicals: pharmacological versus ecotoxicological modes of action.

    PubMed

    Barata, Carlos; Fernández-San Juan, María; Feo, Maria Luisa; Eljarrrat, Ethel; Soares, Amadeu M V M; Barceló, Damià; Baird, Donald J

    2012-09-04

    When considering joint toxic apical effects at higher levels of biological organization, such as the growth of populations, the so-called pharmacological mode of action that relies on toxicological mechanistic effects on molecular target sites may not be relevant. Such effects on population growth rate will depend on the extent to which juvenile and adult survival rates and production rates (juvenile developmental rates and reproduction) are affected by toxic exposure and also by the sensitivity of population growth rates to life-history changes. In such cases, the ecotoxicological mode of action, defined as the crucial life-history trait processes and/or xenobiotic-life-history trait interactions underlying a toxicological effect on population growth rate, should be considered. Life-table response experiments with the crustacean Ceriodaphnia dubia exposed to single and ternary mixtures of nine compounds were conducted to test the hypothesis that joint effects on population growth rates could be predicted from the mixture constituent ecotoxicological mode of action. Joint effects of mixtures containing pharmacologically dissimilar compounds (cadmium, λ-cyhalothrin, and chlorpyrifos) that differentially affected life-history traits contributing to population growth rates were accurately predicted by the independent-action concept. Conversely, the concentration-addition concept accurately predicted joint effects of two different mixtures: one containing pharmacologically similar acting pyrethroids that also affected similarly life-history traits, the other one that included pharmacologically dissimilar compounds (3,4-dichloroaniline, sodium bromide, and fenoxycarb) acting mainly on reproduction rates. These results indicate that when assessing combined effects on population growth rate responses, selection of mixture toxicity conceptual models based on the ecotoxicological mode of action of mixture constituents provided more accurate predictions than those based on

  19. Elucidation of Pseurotin Biosynthetic Pathway Points to Trans-Acting C-Methyltransferase and Source of Chemical Diversity Generation**

    PubMed Central

    Tsunematsu, Yuta; Fukutomi, Manami; Saruwatari, Takayoshi; Noguchi, Hiroshi; Watanabe, Kenji; Hotta, Kinya; Tang, Yi

    2015-01-01

    Pseurotins comprise a family of structurally related Aspergillal natural products having interesting bioactivity. However, little is known about the biosynthetic steps involved in the formation of their complex chemical features. Here, we systematically deleted the pseurotin biosynthetic genes in A. fumigatus and performed in vivo and in vitro characterization of the tailoring enzymes to determine the biosynthetic intermediates and the gene products responsible for the formation of each intermediate. This allowed us to elucidate the main biosynthetic steps leading to the formation of pseurotin A from the predominant precursor, azaspirene. The study revealed the combinatorial nature of the biosynthesis of the pseurotin family of compounds and the intermediates. Most interestingly, we report the first identification of an epoxidase–C-methyltransferase bifunctional fusion protein PsoF that appears to methylate the nascent polyketide backbone carbon atom in trans. PMID:24939566

  20. Toxic Substances; Biphenyl; Test Rule

    EPA Pesticide Factsheets

    This rule promulgates EPA’s decision to require manufacturers and processors to test biphenyl (CAS No: 92—52—4) for environmental effects and chemical fate under section 4(a) of the Toxic Substances Control Act (TSCA).

  1. OIeylamine; Testing Requirements

    EPA Pesticide Factsheets

    EPA is issuing a final rule under section 4(a) of the Toxic Substances Control Act (TSCA) requiring manufacturers and processors of oleylamine (9-octadecenylamine or ODA, CAS Number 112-90—3) to test this chemical.

  2. Federal Register notice: Propylene Oxide; Testing Requirements

    EPA Pesticide Factsheets

    This final rule promulgated under section 4(a) of the Toxic Substances Control Act (TSCA) requires manufacturers and processors of propylene oxide (CAS No. 75-58-9) to test this chemical for developmental toxicity.

  3. Testing Consent Order For Bisphenol A Diglycidyl Ether

    EPA Pesticide Factsheets

    EPA has issued a Testing Consent Order that incorporates an Enforceable Consent Agreement (ECA) pursuant to the Toxic Substances Control Act (TSCA), with the Dow Chemical Company, Shell Oil Company, and Ciba-Geigy Corporation.

  4. Testing Consent Agreement for N-methylpyrrolidone

    EPA Pesticide Factsheets

    EPA has signed an Enforceable Consent Agreement (ECA) pursuant to the Toxic Substances Control Act (TSCA), 15 U.S.C. 2601 et seq., with Arco Chemical Company, BASF Corporation, and International Specialty Products Company.

  5. 40 CFR 710.28 - Persons who must report.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS 2002 Inventory Update Reporting § 710.28 Persons who must... responsible for importing the substance and which controls the import transaction. The import site may in...

  6. 40 CFR 710.48 - Persons who must report.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS Inventory Update Reporting for 2006 and Beyond § 710.48... importing the substance and which controls the import transaction. The import site may in some cases be...

  7. 78 FR 27860 - Revocation of TSCA Section 4 Testing Requirements for One High Production Volume Chemical Substance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-13

    ... invertebrate) and toxicity to algae has not been satisfied by existing studies, and that the fish acute... include tests for octanol/water partition coefficient, acute toxicity to Daphnia, toxicity to algae, and... Daphnia, toxicity to algae, and combined 28-day repeated-dose toxicity with a...

  8. 77 FR 28340 - Revocation of TSCA Section 4 Testing Requirements for One High Production Volume Chemical Substance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-14

    ... toxicity to algae had not been satisfied by existing studies, and that the fish acute toxicity test... include tests for octanol/water partition coefficient, acute toxicity to Daphnia, toxicity to algae, and... coefficient, acute toxicity to Daphnia, toxicity to algae, and combined 28-day repeated-dose toxicity with...

  9. 77 FR 34777 - Seventieth Report of the TSCA Interagency Testing Committee to the Administrator of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... dermal absorption rate data, and 164 High Production Volume (HPV) Challenge Program orphan chemicals; a...-(1,1,3,3- Recommended. tetramethylbutyl)-. 55 December 2004...... 161 High Production Volume (HPV) Recommended. Challenge Program orphan chemicals. 56 August 2005........ 3 HPV Challenge Program...

  10. 40 CFR 799.6755 - TSCA partition coefficient (n-octanol/water), shake flask method.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Potential of Organic Chemicals in Fish. Environmental Science and Technology 8:1113 (1974). (2) Leo, A. et.... Terada, Direct measurements of partition coefficients in an octanol-water system. Journal of... Chemicals, EPA-600/3-78-049 (1978). (5) Mirrless, M.S. et al., Direct measurement of octanol-water...

  11. 76 FR 27271 - TSCA Inventory Update Reporting Modifications; Submission Period Suspension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ..., 15 U.S.C. 2607(a). Consistent with section 553 of the Administrative Procedure Act (APA), 5 U.S.C... the transition to new IUR requirements). Alternatively, under section 553(b)(3)(B) of the APA, the... APA requirement for notice and comment. However, even if it had not, notice and comments on...

  12. Progress report and technology status development of an EG and G Berthold LB-150 alpha/beta particulate monitor for use on the East Tennessee Technology Park Toxic Substances Control Act Incinerator

    SciTech Connect

    Shor, J.T.; Singh, S.P.N.; Gibson, L.V. Jr.

    1998-06-01

    The purpose of this project was to modify and evaluate a commercially available EG and G Berthold LB-150 alpha-beta radionuclide particulate monitor for the high-temperature and moisture-saturation conditions of the East Tennessee Technology Park (formerly K-25 Site) Toxic Substances Control Act (TSCA) Incinerator stack. The monitor was originally outfitted for operation at gas temperatures of 150 F on the defunct Los Alamos National Laboratory (LANL) controlled air incinerator, and the objective was to widen its operating envelope. A laboratory apparatus was constructed that simulated the effects of water-saturated air at the TSCA Incinerator stack-gas temperatures, 183 F. An instrumented set of heat exchangers was constructed to then condition the gas so that the radionuclide monitor could be operated without condensation. Data were collected under the conditions of the elevated temperatures and humidities and are reported herein, and design considerations of the apparatus are provided. The heat exchangers and humidification equipment performed as designed, the Mylar film held, and the instrument suffered no ill effects. However, for reasons as yet undetermined, the sensitivity of the radionuclide detection diminishes as the gas temperature is elevated, whether the gas is humidified or not. The manufacturer has had no experience with (a) the operation of the monitor under these conditions and (b) any commercial market that might exist for an instrument that operates under these conditions. The monitor was not installed into the radiologically contaminated environment of the TSCA Incinerator stack pending resolution of this technical issue.

  13. 40 CFR 799.9135 - TSCA acute inhalation toxicity with histopathology.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... effects on the structure or functions of the respiratory system related to exposure to a chemical... the respiratory system by examining changes in the content of the lavage fluid of the lung. At 24 hrs... significant toxic effects on the respiratory organ system are produced are compared to those levels...

  14. 40 CFR 799.9135 - TSCA acute inhalation toxicity with histopathology.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... effects on the structure or functions of the respiratory system related to exposure to a chemical... the respiratory system by examining changes in the content of the lavage fluid of the lung. At 24 hrs... significant toxic effects on the respiratory organ system are produced are compared to those levels...

  15. 40 CFR 799.9135 - TSCA acute inhalation toxicity with histopathology.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... effects on the structure or functions of the respiratory system related to exposure to a chemical... the respiratory system by examining changes in the content of the lavage fluid of the lung. At 24 hrs... significant toxic effects on the respiratory organ system are produced are compared to those levels...

  16. 40 CFR 799.9135 - TSCA acute inhalation toxicity with histopathology.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... effects on the structure or functions of the respiratory system related to exposure to a chemical... the respiratory system by examining changes in the content of the lavage fluid of the lung. At 24 hrs... significant toxic effects on the respiratory organ system are produced are compared to those levels...

  17. 40 CFR 799.9135 - TSCA acute inhalation toxicity with histopathology.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... effects on the structure or functions of the respiratory system related to exposure to a chemical... the respiratory system by examining changes in the content of the lavage fluid of the lung. At 24 hrs... significant toxic effects on the respiratory organ system are produced are compared to those levels...

  18. 40 CFR 799.9538 - TSCA mammalian bone marrow chromosomal aberration test.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .... Chromosome mutations and related events are the cause of many human genetic diseases and there is substantial... genes are involved in cancer in humans and experimental systems. (b) Source. The source material used in..., then testing in a single sex will be sufficient. Where human exposure to chemicals may be...

  19. 40 CFR 799.9538 - TSCA mammalian bone marrow chromosomal aberration test.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... Chromosome mutations and related events are the cause of many human genetic diseases and there is substantial... genes are involved in cancer in humans and experimental systems. (b) Source. The source material used in..., then testing in a single sex will be sufficient. Where human exposure to chemicals may be...

  20. 40 CFR 799.9538 - TSCA mammalian bone marrow chromosomal aberration test.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... Chromosome mutations and related events are the cause of many human genetic diseases and there is substantial... genes are involved in cancer in humans and experimental systems. (b) Source. The source material used in..., then testing in a single sex will be sufficient. Where human exposure to chemicals may be...

  1. 75 FR 77869 - Endocrine Disruptor Screening Program; Second List of Chemicals for Tier 1 Screening; Extension...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-14

    ... general information contact: The TSCA-Hotline, ABVI-Goodwill, 422 South Clinton Ave., Rochester, NY 14620; telephone number: (202) 554-1404; e-mail address: TSCA-Hotline@epa.gov . SUPPLEMENTARY INFORMATION:...

  2. Privacy Act

    EPA Pesticide Factsheets

    Learn about the Privacy Act of 1974, the Electronic Government Act of 2002, the Federal Information Security Management Act, and other information about the Environmental Protection Agency maintains its records.

  3. Toxic substances Control Act inspection manual. Vol. 1 and Vol. 2. Part 1

    SciTech Connect

    Not Available

    1982-01-01

    Volume one: Toxic Substances Control Act base manual provides general information relating to the act. Inspector authorities and responsibilities are discussed along with the elements and scope of inspections. Procedures which are common to all inspections are outlined in detail: Pre-Inspection Preparation, Entry, Opening Conference, Records Inspection, Documentary Support, Sampling, Chain of Custody, Safety, Closing Conference, and Report Preparation. Special procedures are listed, and all TSCA forms are presented and explained. Information is also included on data systems, warrants, shipping samples, and testifying in court. Volume two: provides the specific information necessary for conducting a comprehensive inspection for PCBs. An Enforcement Strategy details EPA plans and provides an overview of the regulation. Inspecting, sampling, and reporting procedures for PCBs in specific industries are provided.

  4. 78 FR 66279 - Significant New Use Rules on Certain Chemical Substances; Removal of Significant New Use Rules

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-05

    ... general information contact: The TSCA-Hotline, ABVI-Goodwill, 422 South Clinton Ave., Rochester, NY 14620; telephone number: (202) 554-1404; email address: TSCA-Hotline@epa.gov . SUPPLEMENTARY INFORMATION: I....

  5. Chemical Safety Information, Site Security and Fuels Regulatory Relief Act: Public Distribution of Off-Site Consequence Analysis Information Fact Sheet

    EPA Pesticide Factsheets

    Based on assessments of increased risk of terrorist/criminal activity, EPA and DOJ have issued a rule that allows public access to OCA information in ways that are designed to minimize likelihood of chemical accidents and public harm.

  6. 75 FR 80665 - Sixty-Seventh Report of the TSCA Interagency Testing Committee to the Administrator of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-22

    ... chemicals with insufficient dermal absorption rate data, and 207 High Production Volume (HPV) Challenge... (HPV) Recommended. Challenge Program orphan chemicals. 56 August 2005 4 HPV Challenge Program...

  7. TSCA Biotechnology Notifications Status

    EPA Pesticide Factsheets

    This Notifications Table lists only those submissions received under the Biotechnology Regulation, beginning in 1998. From the Table, you can link to a brief summary of select submission and, in many cases, to a fact sheet on the decision reached by OPPT.

  8. Documents for SBAR Panel: Methylene Chloride and N-Methylpyrrolidone; Regulation of Certain Uses Under TSCA Section 6(a)

    EPA Pesticide Factsheets

    SBAR panel to to address the risks resulting from the manufacture, import, processing, distribution in commerce, and use of chemicals, as well as any manner or method of disposal of chemicals: n-methylpyrrolidone (NMP) and methylene chloride

  9. 75 FR 5405 - Sixty-Fifth Report of the TSCA Interagency Testing Committee to the Administrator of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-02

    ... alkylphenols, 12 lead compounds, 16 chemicals with insufficient dermal absorption rate data, and 207 HPV... Volume (HPV) Challenge Program orphan chemicals 56 August 2005 4 HPV Challenge Program Recommended...

  10. Documents for SBAR Panel: Trichloroethylene (TCE); Regulation of Use in Vapor Degreasing under TSCA §6(a)

    EPA Pesticide Factsheets

    SBAR panel to to address risks resulting from the manufacture, import, processing, distribution in commerce, and use of chemicals, as well as any manner or method of disposal of chemicals: Trichloroethylene (TCE)

  11. Clean Water Act Analytical Methods

    EPA Pesticide Factsheets

    EPA publishes laboratory analytical methods (test procedures) that are used by industries and municipalities to analyze the chemical, physical and biological components of wastewater and other environmental samples required by the Clean Water Act.

  12. 75 FR 42441 - Sixty-Sixth Report of the TSCA Interagency Testing Committee to the Administrator of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-21

    ... absorption rate data, and 207 High Production Volume (HPV) Challenge Program orphan chemicals. List of... 2004 203 High Production Recommended Volume (HPV) Challenge Program orphan chemicals 56 August 2005 4 HPV Challenge Program Recommended orphan chemicals 60 May 2007 12 Lead and lead Recommended...

  13. Annual committee reports on significant legislative, judicial and administrative developments in 1983: Solid and Hazardous Waste Committee

    SciTech Connect

    Not Available

    1984-01-01

    There were several significant developments under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA or Superfund), the Resource Conservation and Recovery Act (RCRA), and the Toxic Substance Act (TSCA). Court cases on CERCLA involved basic liability issues, prerequisites to actions, and several miscellaneous issues, while adminstrative developments included issuing the national priorities list and amendments to the National Contingency Plan. Court decisions under RCRA addressed liability of those accepting wastes. The Environmental Protection Agency issued a new definition of solid waste and new regulations. Administrative developments under TSCA covered integrated control programs for new and existing chemicals, the collection of information on existing chemicals, and enforcement and inspection activities. 228 references.

  14. Acting Atoms.

    ERIC Educational Resources Information Center

    Farin, Susan Archie

    1997-01-01

    Describes a fun game in which students act as electrons, protons, and neutrons. This activity is designed to help students develop a concrete understanding of the abstract concept of atomic structure. (DKM)

  15. Inducers of chemical hypoxia act in a gender- and brain region-specific manner on primary astrocyte viability and cytochrome C oxidase.

    PubMed

    Roemgens, André; Singh, Shilpee; Beyer, Cordian; Arnold, Susanne

    2011-07-01

    Oxygen is the ultimate electron acceptor for mitochondrial respiration, a process catalyzed by cytochrome c oxidase (COX). In mammals, oxygen concentration regulates gene transcription of COX subunit IV isoforms. Here, we demonstrate that chemical hypoxia, i.e. inhibition of mitochondrial respiration by application of the COX inhibitors cobalt, cyanide, and azide, affects COX isoform IV-1 and IV-2 transcription in a gender- and brain region-specific way. After treatment with cyanide and cobalt, female cortical and mesencephalic astrocytes, respectively, revealed an up-regulation of COX IV-2 which was accompanied by increased ROS production and necrotic cell death. In male astrocytes, the ratio of COX IV-1/COX IV-2 was lowest after treatment with cobalt and paralleled by highest levels of ROS production and necrosis. These results support the view of a causal correlation of COX IV-2 transcription with cellular oxidative stress and cell death and highlight a gender specificity of these effects. By comparing three toxins, cobalt represented the most potent inducer of overall cell death and resembled most closely the previously observed effects of oxygen deprivation on decreasing the cox4i1/cox4i2 ratio. Overall, an increased sensitivity of male compared with female cell viability towards the toxins was detected. These regulatory responses might be causative for the known gender specificity of toxic and neurodegenerative processes in the brain.

  16. The AOP framework and causality: Meeting chemical risk ...

    EPA Pesticide Factsheets

    Chemical safety assessments are expanding from a focus on a few chemicals (or chemical mixtures) to the broader “universe” of thousands, if not hundreds of thousands of substances that potentially could impact humans or the environment. This is exemplified in regulatory activities such as the REACH program in Europe, or the recent reauthorization of TSCA in the US, which require consideration of the potential impacts of a much greater number of chemicals than in the past. The data needed to address these types of legislated mandates cannot realistically be obtained solely through using the whole animal testing approaches historically employed for chemical risk assessment. Rather, there needs to be an increased emphasis on cost-effective tools that enable robust prediction of potential chemical impacts when empirical data are lacking. Concurrent with the realization that predictive methods will need to play an increasingly prominent role in regulatory toxicology has been the recent explosion in technology in the biological sciences enabling collection of large amounts of pathway-based molecular and biochemical data. For example, genomic techniques and high-throughput (robotic-based) in vitro testing enable the generation of knowledge concerning the effects of chemical perturbation on biological systems in an increasingly efficient and rapid manner. However, a pressing need stemming from these technological advances is the ability to actually apply th

  17. Neverland regulates embryonic moltings through the regulation of ecdysteroid synthesis in the water flea Daphnia magna, and may thus act as a target for chemical disruption of molting.

    PubMed

    Sumiya, Eri; Ogino, Yukiko; Toyota, Kenji; Miyakawa, Hitoshi; Miyagawa, Shinichi; Iguchi, Taisen

    2016-11-01

    Embryo development in arthropods is accompanied by a series of moltings. A cladoceran crustacean Daphnia magna molts three times before reaching first instar neonate during embryogenesis. Previous studies argued ecdysteroids might regulate D. magna embryogenesis. However, no direct evidence between innate ecdysteroids fluctuation and functions has been forthcoming. Recently, we identified genes involved in ecdysteroid synthesis called, neverland (neverland1 and neverland 2) and shade and in the ecdysteroid degradation (Cyp18a1). To understand the physiological roles of ecdysteroids in D. magna embryos, we performed expression and functional analyzes of those genes. Examining innate ecdysteroids titer during embryogenesis showed two surges of ecdysteroids titer at 41 and 61 h after oviposition. The first and second embryonic moltings occurred at each ecdysteroid surge. Expression of neverland1 and shade began to increase before the first peak in ecdysteroid. Knockdown of neverland1 or shade by RNAi technique caused defects in embryonic moltings and subsequent development. The ecdysteroids titer seemingly decreased in nvd1-knowckdown embryos. Knockdown of Cyp18a1 resulted in early embryonic lethality before the first molting. Our in situ hybridization analysis revealed that nvd1 was prominently expressed in embryonic gut epithelium suggesting the site for an initial step of ecdysteroidgenesis, a conversion of cholesterol to 7-dehydrocholesterol and possibly for ecdysone production. Taken together, de novo ecdysteroid synthesis by nvd1 in the gut epithelial cells stimulates molting, which is indispensable for D. magna embryo development. These findings identify neverland as a possible target for chemicals, including various pesticides that are known to disrupt molting, development and reproduction. Copyright © 2016 John Wiley & Sons, Ltd.

  18. 40 CFR 710.39 - How do I submit the required information?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Partial Updating of the TSCA Chemical Inventory Data Base,” via the Internet or the TSCA Hotline. (c... submitting a request for this information as follows: (1) By phone. Call the EPA TSCA Hotline at (202) 554-1404. (2) By e-mail. Send an e-mail request for this information to the EPA TSCA Hotline at...

  19. Balancing Act

    ERIC Educational Resources Information Center

    Kennedy, Mike

    2007-01-01

    For some administrators and planners, designing and building education facilities may sometimes seem like a circus act--trying to project a persona of competence and confidence while juggling dozens of issues. Meanwhile, the audience--students, staff members and taxpayers--watch and wait with anticipation in hopes of getting what they paid for and…

  20. TSCA Work Plan Chemical Risk Assessment HHCB 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-g-2- benzopyran

    EPA Pesticide Factsheets

    HHCB is one of the most widely used polycyclic musk fragrance ingredients in a range of consumer products including perfumes, cosmetics, shampoos, lotions, detergents, fabric softeners, and household cleaners.

  1. 40 CFR 766.1 - Scope and purpose.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT DIBENZO... requirements for testing under section 4 of the Toxic Substances Control Act (TSCA), 15 U.S.C. 2603, to... identified as possible precursors to HDD/HDF formation, to report on chemical substances produced from...

  2. Field Evaluation of MERCEM Mercury Emission Analyzer System at the Oak Ridge TSCA Incinerator East Tennessee Technology Park Oak Ridge, Tennessee

    SciTech Connect

    2000-03-01

    The authors reached the following conclusions: (1) The two-month evaluation of the MERCEM total mercury monitor from Perkin Elmer provided a useful venue in determining the feasibility of using a CEM to measure total mercury in a saturated flue gas. (2) The MERCEM exhibited potential at a mixed waste incinerator to meet requirements proposed in PS12 under conditions of operation with liquid feeds only at stack mercury concentrations in the range of proposed MACT standards. (3) Performance of the MERCEM under conditions of incinerating solid and liquid wastes simultaneously was less reliable than while feeding liquid feeds only for the operating conditions and configuration of the host facility. (4) The permeation tube calibration method used in this test relied on the CEM internal volumetric and time constants to relate back to a concentration, whereas a compressed gas cylinder concentration is totally independent of the analyzer mass flowmeter and flowrates. (5) Mercury concentration in the compressed gas cylinders was fairly stable over a 5-month period. (6) The reliability of available reference materials was not fully demonstrated without further evaluation of their incorporation into routine operating procedures performed by facility personnel. (7) The degree of mercury control occurring in the TSCA Incinerator off-gas cleaning system could not be quantified from the data collected in this study. (8) It was possible to conduct the demonstration at a facility incinerating radioactively contaminated wastes and to release the equipment for later unrestricted use elsewhere. (9) Experience gained by this testing answered additional site-specific and general questions regarding the operation and maintenance of CEMs and their use in compliance monitoring of total mercury emissions from hazardous waste incinerators.

  3. 40 CFR 710.1 - Scope and compliance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 710.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS General Provisions § 710.1 Scope and compliance. (a) This part... process chemical substances for commercial purposes under section 8(a) of the Toxic Substances Control...

  4. 40 CFR 710.1 - Scope and compliance.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 710.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS General Provisions § 710.1 Scope and compliance. (a) This part... process chemical substances for commercial purposes under section 8(a) of the Toxic Substances Control...

  5. Chemical Facility Security Improvement Act of 2013

    THOMAS, 113th Congress

    Rep. Jackson Lee, Sheila [D-TX-18

    2013-01-03

    02/12/2013 Referred to the Subcommittee on Cybersecurity, Infrastructure Protection, and Security Technologies. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  6. Chemical Facility Security Improvement Act of 2009

    THOMAS, 111th Congress

    Rep. Jackson-Lee, Sheila [D-TX-18

    2009-01-07

    02/05/2009 Referred to the Subcommittee on Transportation Security and Infrastructure Protection. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  7. 78 FR 44857 - Seventy-Second Report of the TSCA Interagency Testing Committee to the Administrator of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-24

    ... List CAS No. Chemical name 75-12-7 Formamide. 88-72-2 Benzene, 1-methyl-2-nitro-; o-nitrotoluene. 89-72...-13-6 1H-Indene; indene. 96-18-4 Propane, 1,2,3-trichloro-; 1,2,3-trichloropropane. 99-08-1 Benzene, 1...-; methylcyclohexane. 121-14-2 Benzene, 1-methyl-2,4-dinitro-; 2,4- dinitrotoluene. 287-92-3 Cyclopentane....

  8. 77 FR 20354 - Meetings; Sunshine Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-04

    ... From the Federal Register Online via the Government Publishing Office CHEMICAL SAFETY AND HAZARD INVESTIGATION BOARD Meetings; Sunshine Act The U.S. Chemical Safety and Hazard Investigation Board (CSB....S. Chemical Safety and Hazard Investigation Board at (202) 261-7600, or visit our Web site at:...

  9. 76 FR 69238 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-08

    ...; ] CHEMICAL SAFETY AND HAZARD INVESTIGATION BOARD Sunshine Act Meeting In connection with its investigation into three iron dust flash fires at the Hoeganaes facility in Gallatin, TN., the U.S. Chemical Safety... prior to the public meeting. For more information, please contact the Chemical Safety and...

  10. Microorganisms and Chemical Pollution

    ERIC Educational Resources Information Center

    Alexander, M.

    1973-01-01

    Discusses the importance of microorganisms in chemical pollution and pollution abatement. Selected chemical pollutants are chosen to illustrate that microorganisms synthesize hazardous substances from reasonably innocuous precursors, while others act as excellent environmental decontaminating agents by removing undesirable natural and synthetic…

  11. 75 FR 70583 - Cobalt Lithium Manganese Nickel Oxide; Withdrawal of Significant New Use Rule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-18

    ... AGENCY 40 CFR Parts 9 and 721 RIN 2070-AB27 Cobalt Lithium Manganese Nickel Oxide; Withdrawal of... Control Act (TSCA) for the chemical substance identified as cobalt lithium manganese nickel oxide (CAS No... cobalt lithium manganese nickel oxide (PMN P-04-269; CAS No. 182442-95-1) at 40 CFR 721.10201 because...

  12. Tetrabromobisphenol A; Final Test Rule

    EPA Pesticide Factsheets

    EPA is issuing a final test rule, under section 4 of the Toxic Substances Control Act (TSCA), requiring manufacturers and processors of tetrabromobisphenol A (TBBPA. CAS No. 79—94—7) to perform testing for chemical fate and environmental effects.

  13. Polyhalogenated Dibenzo-p-Dioxins/ Dibenzofurans; Testing and Reporting Requirements; Final Rule

    EPA Pesticide Factsheets

    This document promulgates regulations under sections 4 and 8 of the Toxic Substances Control Act (TSCA). 15 U.S.C. 2603 and 2607 for chemicals which may be contaminated with chlorinated and brominated dibenzo-p-dioxins (HDDs) and dibenzofurans (HDFs)

  14. 40 CFR 710.57 - Recordkeeping requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Recordkeeping requirements. 710.57 Section 710.57 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS Inventory Update Reporting for 2006 and Beyond §...

  15. 40 CFR 710.49 - Persons not subject to this subpart.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Persons not subject to this subpart. 710.49 Section 710.49 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS Inventory Update Reporting for 2006 and...

  16. 40 CFR 710.55 - Duplicative reporting.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Duplicative reporting. 710.55 Section 710.55 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS Inventory Update Reporting for 2006 and Beyond §...

  17. 40 CFR 710.38 - Confidentiality.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Confidentiality. 710.38 Section 710.38 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS 2002 Inventory Update Reporting § 710.38 Confidentiality. (a) Any...

  18. 40 CFR 710.50 - Activities for which reporting is not required.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Activities for which reporting is not required. 710.50 Section 710.50 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS Inventory Update Reporting for 2006 and...

  19. 40 CFR 710.29 - Persons not subject to this subpart.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Persons not subject to this subpart. 710.29 Section 710.29 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS 2002 Inventory Update Reporting § 710.29...

  20. 40 CFR 710.33 - When to report.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false When to report. 710.33 Section 710.33 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS 2002 Inventory Update Reporting § 710.33 When to report. All...

  1. 40 CFR 710.30 - Activities for which reporting is not required.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Activities for which reporting is not required. 710.30 Section 710.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS 2002 Inventory Update Reporting §...

  2. 40 CFR 710.48 - Persons who must report.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Persons who must report. 710.48 Section 710.48 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS Inventory Update Reporting for 2006 and Beyond §...

  3. 40 CFR 710.43 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Definitions. 710.43 Section 710.43 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS Inventory Update Reporting for 2006 and Beyond § 710.43 Definitions....

  4. 40 CFR 710.35 - Duplicative reporting.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Duplicative reporting. 710.35 Section 710.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS 2002 Inventory Update Reporting § 710.35 Duplicative...

  5. 40 CFR 710.23 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Definitions. 710.23 Section 710.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS 2002 Inventory Update Reporting § 710.23 Definitions. In addition to...

  6. 40 CFR 710.37 - Recordkeeping requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Recordkeeping requirements. 710.37 Section 710.37 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS 2002 Inventory Update Reporting § 710.37...

  7. 40 CFR 710.28 - Persons who must report.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Persons who must report. 710.28 Section 710.28 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS 2002 Inventory Update Reporting § 710.28 Persons who...

  8. 40 CFR 710.53 - When to report.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false When to report. 710.53 Section 710.53 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS Inventory Update Reporting for 2006 and Beyond § 710.53 When to report....

  9. Hydroquinone Testing Requirements

    EPA Pesticide Factsheets

    On January 4, 1984, the EPA proposed, under section 4(a) of the Toxic Substances Control Act (TSCA), that manufacturers and processors of hydroquinone (CAS No. 123-31-9) conduct health and environmental effects testing of that chemical (49 FR 438).

  10. 40 CFR 711.15 - Reporting information to EPA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Reporting information to EPA. 711.15... CONTROL ACT TSCA CHEMICAL DATA REPORTING REQUIREMENTS § 711.15 Reporting information to EPA. For the 2012... information is known to or reasonably ascertainable by that person. (a) Reporting information to EPA....

  11. 40 CFR 710.55 - Duplicative reporting.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Duplicative reporting. 710.55 Section 710.55 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS Inventory Update Reporting for 2006 and Beyond §...

  12. 40 CFR 710.53 - When to report.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false When to report. 710.53 Section 710.53 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS Inventory Update Reporting for 2006 and Beyond § 710.53 When to report....

  13. 40 CFR 710.50 - Activities for which reporting is not required.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Activities for which reporting is not required. 710.50 Section 710.50 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS Inventory Update Reporting for 2006 and...

  14. 40 CFR 710.37 - Recordkeeping requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Recordkeeping requirements. 710.37 Section 710.37 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS 2002 Inventory Update Reporting § 710.37...

  15. 40 CFR 710.29 - Persons not subject to this subpart.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Persons not subject to this subpart. 710.29 Section 710.29 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS 2002 Inventory Update Reporting § 710.29...

  16. 40 CFR 710.57 - Recordkeeping requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Recordkeeping requirements. 710.57 Section 710.57 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS Inventory Update Reporting for 2006 and Beyond §...

  17. 40 CFR 710.30 - Activities for which reporting is not required.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Activities for which reporting is not required. 710.30 Section 710.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS 2002 Inventory Update Reporting §...

  18. 40 CFR 710.38 - Confidentiality.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS 2002 Inventory Update Reporting § 710.38 Confidentiality. (a) Any person... if the identity of that substance is treated as confidential in the Master Inventory File as of...

  19. 40 CFR 710.49 - Persons not subject to this subpart.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Persons not subject to this subpart. 710.49 Section 710.49 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS Inventory Update Reporting for 2006 and...

  20. 40 CFR 710.35 - Duplicative reporting.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Duplicative reporting. 710.35 Section 710.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS 2002 Inventory Update Reporting § 710.35 Duplicative...

  1. Contact Us about Asbestos

    EPA Pesticide Factsheets

    How to contact EPA for more information on asbestos, including state and regional contacts, EPA’s Asbestos Abatement/Management Ombudsman and the Toxic Substances Control Act (TSCA) Assistance Information Service (TSCA Hotline).

  2. 78 FR 78810 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-27

    ... From the Federal Register Online via the Government Publishing Office CHEMICAL SAFETY AND HAZARD INVESTIGATION BOARD Sunshine Act Meeting TIME AND DATE: January 30, 2014, 6:30 p.m.-9:00 p.m. PST. PLACE.... MATTERS TO BE CONSIDERED: The Chemical Safety and Hazard Investigation Board (CSB) will convene a...

  3. 78 FR 78811 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-27

    ... From the Federal Register Online via the Government Publishing Office CHEMICAL SAFETY AND HAZARD INVESTIGATION BOARD Sunshine Act Meeting TIME AND DATE: January 15, 2014, 6:30 p.m.-8:30 p.m. PST. PLACE: City... public. Matters To Be Considered The Chemical Safety and Hazard Investigation Board (CSB) will convene...

  4. 78 FR 65610 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-01

    ... From the Federal Register Online via the Government Publishing Office CHEMICAL SAFETY AND HAZARD INVESTIGATION BOARD Sunshine Act Meeting TIME AND DATE: November 14, 2013, 10:30 a.m.-1:30 p.m. CST. PLACE...: Open to the public. MATTERS TO BE CONSIDERED: The Chemical Safety and Hazard Investigation Board...

  5. 78 FR 1832 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-09

    ... From the Federal Register Online via the Government Publishing Office CHEMICAL SAFETY AND HAZARD INVESTIGATION BOARD Sunshine Act Meeting TIME AND DATE: January 17, 2013; 2:30 p.m. EST. PLACE: Ronald Reagan.... STATUS: Open to the public. MATTERS TO BE CONSIDERED: The Chemical Safety and Hazard Investigation...

  6. Chemical Accident Prevention - Chemicals in your Community

    EPA Pesticide Factsheets

    This pamphlet summarizes the information you can obtain under Emergency Planning and Community Right-to-Know and Clean Air Act, how you can use these sources to build a snapshot of chemicals stored and released, and how SERCs and LEPCs can improve safety.

  7. The new Clean Air Act

    SciTech Connect

    Padmanabha, A.P. ); Olem, H. )

    1991-05-01

    This article is a title by title review of the new Clean Air Act and how it affects water quality and wastewater treatment. The bill provides for restoring and protecting lakes and rivers by reducing acid-rain-causing emissions and toxics from nonpoint-source runoff. Topics covered include urban smog, mobile sources, air toxics, acid rain, permits, ozone-depleting chemicals, enforcement, and the law's socio-economic impacts.

  8. Groundwater chemicals desk reference

    SciTech Connect

    Montgomery, J.H.; Welkom, L.M.

    1990-01-01

    Information is compiled on more than 135 compounds that may be groundwater pollutants. The compounds profiled include all the Priority Pollutants promulgated by the US EPA under the Clean Water Act (CWA) of 1977. Many of these priority pollutants were included among the Target Compounds promulgated by the EPA under the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) in 1980 and the Superfund Amendments and Reauthorization Act (SARA) of 1986. All chemicals described in the book are classified as priority pollutants and/or target compounds. For each chemical, the following information is given: (1) synonyms; (2) structural formula; (3) CAS Registry number; (4) DOT designation; (5) empirical formula; (6) formula weight; (7) RETCS number; (8) physical and chemical properties; (9) fire hazards; (10) health hazard data; and (11) manufacturing data and/or selected manufacturers.

  9. 77 FR 24698 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ... exposure to chemical substances and mixtures. Drugs, cosmetics, foods, food additives, pesticides, and nuclear materials are exempt from TSCA. Under TSCA section 4, EPA must assure that appropriate tests...

  10. Chemical Emergencies

    MedlinePlus

    When a hazardous chemical has been released, it may harm people's health. Chemical releases can be unintentional, as in the case of an ... the case of a terrorist attack with a chemical weapon. Some hazardous chemicals have been developed by ...

  11. Privacy Act Statement

    EPA Pesticide Factsheets

    Any information you provide to the Environmental Protection Agency’s (EPA) Suspension and Debarment Program will be governed by the Privacy Act and will be included in the EPA Debarment and Suspension Files, a Privacy Act system of records.

  12. ACTS data center

    NASA Technical Reports Server (NTRS)

    Syed, Ali; Vogel, Wolfhard J.

    1993-01-01

    Viewgraphs on ACTS Data Center status report are included. Topics covered include: ACTS Data Center Functions; data flow overview; PPD flow; RAW data flow; data compression; PPD distribution; RAW Data Archival; PPD Audit; and data analysis.

  13. Recovery Act Milestones

    ScienceCinema

    Rogers, Matt

    2016-07-12

    Every 100 days, the Department of Energy is held accountable for a progress report on the American Recovery and Reinvestment Act. Update at 200 days, hosted by Matt Rogers, Senior Advisor to Secretary Steven Chu for Recovery Act Implementation.

  14. Autism: Why Act Early?

    MedlinePlus

    ... What's this? Submit Button Past Emails CDC Features Autism: Why Act Early? Language: English Español (Spanish) Recommend ... helped the world make sense." Florida teenager with Autism Spectrum Disorder "Because my parents acted early, I ...

  15. Recovery Act Milestones

    SciTech Connect

    Rogers, Matt

    2009-01-01

    Every 100 days, the Department of Energy is held accountable for a progress report on the American Recovery and Reinvestment Act. Update at 200 days, hosted by Matt Rogers, Senior Advisor to Secretary Steven Chu for Recovery Act Implementation.

  16. The dermatology acting internship.

    PubMed

    Stephens, John B; Raimer, Sharon S; Wagner, Richard F

    2011-07-15

    Acting internships are an important component of modern day medical school curriculum. Several specialties outside of internal medicine now offer acting internship experiences to fourth year medical students. We have found that a dermatology acting internship is a valuable experience for fourth year medical students who are interested in pursuing a residency in dermatology. Our experience with the dermatology acting internship over the 2010-2011 academic year is described.

  17. Chemical Peel

    MedlinePlus

    ... be done at different depths — light, medium or deep — depending on your desired results. Each type of ... chemical peel after 12 months to maintain results. Deep chemical peel. A deep chemical peel removes skin ...

  18. 77 FR 4947 - Proposed Significant New Use Rules on Certain Chemical Substances; Reopening of Comment Period

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ...; email address: moss.kenneth@epa.gov . For general information contact: The TSCA-Hotline, ABVI-Goodwill...-Hotline@epa.gov . SUPPLEMENTARY INFORMATION: This document reopens the public comment period...

  19. 78 FR 55326 - Determinations Regarding Use of Chemical Weapons in Syria Under the Chemical and Biological...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-10

    ... Determinations Regarding Use of Chemical Weapons in Syria Under the Chemical and Biological Weapons Control and... to Section 306(a) of the Chemical and Biological Weapons Control and Warfare Elimination Act of 1991, 22 U.S.C. 5604(a), that the Government of Syria has used chemical weapons in violation...

  20. Quantum Measurement Act as a Speech Act

    NASA Astrophysics Data System (ADS)

    Schneider, Jean

    2005-10-01

    I show that the quantum measurement problem can be understood if the measurement is seen as a "speech act" in the sense of modern language theory. The reduction of the state vector is in this perspective an intersubjective -- or, better, a-subjective -- symbolic process. I then give some perspectives on applications to the "Mind-Body Problem".

  1. 76 FR 76935 - Impact of Implementing the Chemical Weapons Convention (CWC) on Commercial Activities Involving...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-09

    ... Bureau of Industry and Security Impact of Implementing the Chemical Weapons Convention (CWC) on... implementation of the Chemical Weapons Convention (CWC), through the Chemical Weapons Convention Implementation Act (CWCIA), and the Chemical Weapons Convention Regulations (CWCR), has had on commercial...

  2. 75 FR 69630 - Impact of Implementation of the Chemical Weapons Convention on Commercial Activities Involving...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-15

    ...-0543-02] Impact of Implementation of the Chemical Weapons Convention on Commercial Activities Involving... Chemical Weapons Convention (CWC), through the Chemical Weapons Convention Implementation Act (CWCIA) and the Chemical Weapons Convention Regulations (CWCR), has had on commercial activities...

  3. 78 FR 75910 - Impact of the Implementation of the Chemical Weapons Convention (CWC) on Legitimate Commercial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-13

    ...; ] DEPARTMENT OF COMMERCE Bureau of Industry and Security Impact of the Implementation of the Chemical Weapons... Chemical Weapons Convention (CWC), through the Chemical Weapons Convention Implementation Act (CWCIA) and the Chemical Weapons Convention Regulations (CWCR), has had on commercial activities...

  4. ACT and College Success

    ERIC Educational Resources Information Center

    Bleyaert, Barbara

    2010-01-01

    What is the relationship between ACT scores and success in college? For decades, admissions policies in colleges and universities across the country have required applicants to submit scores from a college entrance exam, most typically the ACT (American College Testing) or SAT (Scholastic Aptitude Test). This requirement suggests that high school…

  5. Clean Air Act Text

    EPA Pesticide Factsheets

    The Clean Air Act is the law that defines EPA's responsibilities for protecting and improving the nation's air quality and the stratospheric ozone layer. The last major change in the law, the Clean Air Act Amendments of 1990, enacted in 1990 by Congress.

  6. Americans With Disabilities Act.

    PubMed

    Walk, E E; Ahn, H C; Lampkin, P M; Nabizadeh, S A; Edlich, R F

    1993-01-01

    The Americans with Disabilities Act gives all Americans with disabilities a chance to achieve the same quality of life that individuals without disabilities enjoy. This act prohibits discrimination on the basis of disabilities in employment, public services, privately operated public accommodations, services, and telecommunications. The Americans with Disabilities Act is divided into five titles. Title I of the act pertains to discrimination against the disabled in the workplace. Title II prevents discrimination against persons with a disability in state and local government services. Title III prohibits discrimination against persons with disabilities in places of public accommodations and commercial facilities. Title IV ensures that companies offering telephone services to the general public provide special services for individuals with hearing and speech impairments. Under the enforcement provisions of the Americans with Disabilities Act, stringent penalties will be implemented for failure to comply with its provisions.

  7. 40 CFR 766.25 - Chemical substances for testing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Chemical substances for testing. 766... SUBSTANCES CONTROL ACT DIBENZO-PARA-DIOXINS/DIBENZOFURANS Specific Chemical Testing/Reporting Requirements § 766.25 Chemical substances for testing. (a) Listing of chemical substances. Chemical...

  8. 40 CFR 766.25 - Chemical substances for testing.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Chemical substances for testing. 766... SUBSTANCES CONTROL ACT DIBENZO-PARA-DIOXINS/DIBENZOFURANS Specific Chemical Testing/Reporting Requirements § 766.25 Chemical substances for testing. (a) Listing of chemical substances. Chemical...

  9. 40 CFR 766.25 - Chemical substances for testing.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Chemical substances for testing. 766... SUBSTANCES CONTROL ACT DIBENZO-PARA-DIOXINS/DIBENZOFURANS Specific Chemical Testing/Reporting Requirements § 766.25 Chemical substances for testing. (a) Listing of chemical substances. Chemical...

  10. 40 CFR 766.25 - Chemical substances for testing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Chemical substances for testing. 766... SUBSTANCES CONTROL ACT DIBENZO-PARA-DIOXINS/DIBENZOFURANS Specific Chemical Testing/Reporting Requirements § 766.25 Chemical substances for testing. (a) Listing of chemical substances. Chemical...

  11. 40 CFR 766.25 - Chemical substances for testing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Chemical substances for testing. 766... SUBSTANCES CONTROL ACT DIBENZO-PARA-DIOXINS/DIBENZOFURANS Specific Chemical Testing/Reporting Requirements § 766.25 Chemical substances for testing. (a) Listing of chemical substances. Chemical...

  12. 21 CFR 1310.13 - Exemption of chemical mixtures; application.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Exemption of chemical mixtures; application. 1310... REPORTS OF LISTED CHEMICALS AND CERTAIN MACHINES § 1310.13 Exemption of chemical mixtures; application. (a... application of all or any part of the Act a chemical mixture consisting of two or more chemical components,...

  13. 21 CFR 1310.13 - Exemption of chemical mixtures; application.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Exemption of chemical mixtures; application. 1310... REPORTS OF LISTED CHEMICALS AND CERTAIN MACHINES § 1310.13 Exemption of chemical mixtures; application. (a... application of all or any part of the Act a chemical mixture consisting of two or more chemical components,...

  14. 21 CFR 1310.13 - Exemption of chemical mixtures; application.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 9 2014-04-01 2014-04-01 false Exemption of chemical mixtures; application. 1310... REPORTS OF LISTED CHEMICALS AND CERTAIN MACHINES § 1310.13 Exemption of chemical mixtures; application. (a... application of all or any part of the Act a chemical mixture consisting of two or more chemical components,...

  15. 21 CFR 1310.13 - Exemption of chemical mixtures; application.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 9 2012-04-01 2012-04-01 false Exemption of chemical mixtures; application. 1310... REPORTS OF LISTED CHEMICALS AND CERTAIN MACHINES § 1310.13 Exemption of chemical mixtures; application. (a... application of all or any part of the Act a chemical mixture consisting of two or more chemical components,...

  16. Review of organic nitrile incineration at the Toxic Substances Control Act Incinerator

    SciTech Connect

    1997-10-01

    Lockheed Martin Energy Systems, Inc. (LMES) operates the East Tennessee Technology Park (ETTP), formerly called the Oak Ridge K-25 Site, where uranium was enriched under contract with the US Department of Energy (DOE). Currently, ETTP missions include environmental management, waste management (WM), and the development of new technologies. As part of its WM mission, ETTP operates the TSCA (Toxic Substances Control Act) Incinerator (TSCAI) for treatment of hazardous waste and polychlorinated biphenyls (PCBs) contaminated with low-level radioactivity. Beginning in the autumn of 1995, employees from diverse ETTP buildings and departments reported experiencing headaches, fatigue, depression, muscle aches, sleeplessness, and muscle tremors. These symptoms were judged by a physician in the ETTP Health Services Department to be consistent with chronic exposures to hydrogen cyanide (HCN). The National Institute for Occupational Safety and Health (NIOSH) was called in to perform a health hazard evaluation to ascertain whether the employees` illnesses were in fact caused by occupational exposure to HCN. The NIOSH evaluation found no patterns for employees` reported symptoms with respect to work location or department. NIOSH also conducted a comprehensive air sampling study, which did not detect airborne cyanides at the ETTP. Employees, however, expressed concerns that the burning of nitrile-bearing wastes at the TSCAI might have produced HCN as a combustion product. Therefore, LMES and DOE established a multidisciplinary team (TSCAI Technical Review Team) to make a more detailed review of the possibility that combustion of nitrile-bearing wastes at the TSCAI might have either released nitriles or created HCN as a product of incomplete combustion (PIC).

  17. Acts of kindness and acts of novelty affect life satisfaction.

    PubMed

    Buchanan, Kathryn E; Bardi, Anat

    2010-01-01

    The present experiment was designed to establish the effects of acts of kindness and acts of novelty on life satisfaction. Participants aged 18-60 took part on a voluntary basis. They were randomly assigned to perform either acts of kindness, acts of novelty, or no acts on a daily basis for 10 days. Their life satisfaction was measured before and after the 10-day experiment. As expected, performing acts of kindness or acts of novelty resulted in an increase in life satisfaction.

  18. Draconian dress act repealed.

    PubMed

    Mhone, C

    1994-01-01

    The Dress Act was put into place in Malawi by the government of President Kamuzu Banda after the long period of direct colonialism. The act made it illegal for women in Malawi to be seen publicly wearing dresses which did not completely cover their knees or wearing pants; men had to wear their hair short. Police officers even scrutinized women's attire at private house parties and in homes. The autocratic political structure established by Banda, however, was voted out in a referendum June 14, 1993. Pressure by opposition forces such as the United Democratic Front forced a repeal of the act on November 16 of the same year. The repeal was vigorously attacked by female Parliament members as a move which would result in moral degradation and an increase in the level of sexual harassment against women. Other citizens and tourists have generally detested the act. The act has most certainly kept many potential visitors from vacationing in Malawi. Some expert observers think that repeals of the Dress Act, the Forfeiture Act, and legislation which allowed the government to detain opposition figures without trial were done to garner support from the Paris Club for the resumption of balance of payments support suspended due to the country's poor human rights record.

  19. Opportunities for artificial intelligence application in computer- aided management of mixed waste incinerator facilities

    SciTech Connect

    Rivera, A.L.; Ferrada, J.J.; Singh, S.P.N.

    1992-01-01

    The Department of Energy/Oak Ridge Field Office (DOE/OR) operates a mixed waste incinerator facility at the Oak Ridge K-25 Site. It is designed for the thermal treatment of incinerable liquid, sludge, and solid waste regulated under the Toxic Substances Control Act (TSCA) and the Resource Conservation and Recovery Act (RCRA). This facility, known as the TSCA Incinerator, services seven DOE/OR installations. This incinerator was recently authorized for production operation in the United States for the processing of mixed (radioactively contaminated-chemically hazardous) wastes as regulated under TSCA and RCRA. Operation of the TSCA Incinerator is highly constrained as a result of the regulatory, institutional, technical, and resource availability requirements. These requirements impact the characteristics and disposition of incinerator residues, limits the quality of liquid and gaseous effluents, limit the characteristics and rates of waste feeds and operating conditions, and restrict the handling of the waste feed inventories. This incinerator facility presents an opportunity for applying computer technology as a technical resource for mixed waste incinerator operation to facilitate promoting and sustaining a continuous performance improvement process while demonstrating compliance. Demonstrated computer-aided management systems could be transferred to future mixed waste incinerator facilities.

  20. Opportunities for artificial intelligence application in computer- aided management of mixed waste incinerator facilities

    SciTech Connect

    Rivera, A.L.; Ferrada, J.J.; Singh, S.P.N.

    1992-05-01

    The Department of Energy/Oak Ridge Field Office (DOE/OR) operates a mixed waste incinerator facility at the Oak Ridge K-25 Site. It is designed for the thermal treatment of incinerable liquid, sludge, and solid waste regulated under the Toxic Substances Control Act (TSCA) and the Resource Conservation and Recovery Act (RCRA). This facility, known as the TSCA Incinerator, services seven DOE/OR installations. This incinerator was recently authorized for production operation in the United States for the processing of mixed (radioactively contaminated-chemically hazardous) wastes as regulated under TSCA and RCRA. Operation of the TSCA Incinerator is highly constrained as a result of the regulatory, institutional, technical, and resource availability requirements. These requirements impact the characteristics and disposition of incinerator residues, limits the quality of liquid and gaseous effluents, limit the characteristics and rates of waste feeds and operating conditions, and restrict the handling of the waste feed inventories. This incinerator facility presents an opportunity for applying computer technology as a technical resource for mixed waste incinerator operation to facilitate promoting and sustaining a continuous performance improvement process while demonstrating compliance. Demonstrated computer-aided management systems could be transferred to future mixed waste incinerator facilities.

  1. ACTS mobile SATCOM experiments

    NASA Technical Reports Server (NTRS)

    Abbe, Brian S.; Frye, Robert E.; Jedrey, Thomas C.

    1993-01-01

    Over the last decade, the demand for reliable mobile satellite communications (satcom) for voice, data, and video applications has increased dramatically. As consumer demand grows, the current spectrum allocation at L-band could become saturated. For this reason, NASA and the Jet Propulsion Laboratory are developing the Advanced Communications Technology Satellites (ACTS) mobile terminal (AMT) and are evaluating the feasibility of K/Ka-band (20/30 GHz) mobile satcom to meet these growing needs. U.S. industry and government, acting as co-partners, will evaluate K/Ka-band mobile satcom and develop new technologies by conducting a series of applications-oriented experiments. The ACTS and the AMT testbed will be used to conduct these mobile satcom experiments. The goals of the ACTS Mobile Experiments Program and the individual experiment configurations and objectives are further presented.

  2. Disabilities Act in Action.

    ERIC Educational Resources Information Center

    Daynes, Kristine S.

    1990-01-01

    Eight true or false questions explore implications of the Americans with Disabilities Act of 1990. Topics include AIDS, drug abuse, undue hardship, reasonable accommodation, and company size affected by the law. (SK)

  3. Chemical sensor

    NASA Technical Reports Server (NTRS)

    Rauh, R. David (Inventor)

    1990-01-01

    A sensor for detecting a chemical substance includes an insertion element having a structure which enables insertion of the chemical substance with a resulting change in the bulk electrical characteristics of the insertion element under conditions sufficient to permit effective insertion; the change in the bulk electrical characteristics of the insertion element is detected as an indication of the presence of the chemical substance.

  4. 75 FR 2481 - Sunshine Act; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    ... From the Federal Register Online via the Government Publishing Office CHEMICAL SAFETY AND HAZARD INVESTIGATION BOARD Sunshine Act; Notice of Meeting In connection with its investigation into a natural gas... Chemical Safety and Hazard Investigation Board (CSB) announces that it will hold a public meeting...

  5. 77 FR 75566 - Significant New Use Rule on Certain Chemical Substances; Withdrawal of Significant New Use Rules

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-21

    ... January 2, 2013. FOR FURTHER INFORMATION CONTACT: For technical information contact: Kenneth Moss... address: Moss.Kenneth@epa.gov . For general information contact: The TSCA-Hotline, ABVI-Goodwill,...

  6. Chemical burns

    PubMed Central

    Cartotto, Robert C.; Peters, Walter J.; Neligan, Peter C.; Douglas, Leith G.; Beeston, Jeff

    1996-01-01

    Objectives To report a burn unit’s experience with chemical burns and to discuss the fundamental principles in managing chemical burns. Design A chart review. Setting A burn centre at a major university-affiliated hospital. Patients Twenty-four patients with chemical burns, representing 2.6% of all burn admissions over an 8-year period at the Ross Tilley Regional Adult Burn Centre. Seventy-five percent of the burn injuries were work-related accidents. Chemicals involved included hydrofluoric acid, sulfuric acid, black liquor, various lyes, potassium permanganate and phenol. Results Fourteen patients required excision and skin grafting. Complications were frequent and included ocular chemical contacts, wound infections, tendon exposures, toe amputation and systemic reactions from absorption of chemical. One patient died from a chemical scald burn to 98% of the body surface area. Conclusions The key principles in the management of chemical burns include removal of the chemical, copious irrigation, limited use of antidotes, correct estimation of the extent of injury, identification of systemic toxicity, treatment of ocular contacts and management of chemical inhalation injury. Individualized treatment is emphasized. PMID:8640619

  7. 40 CFR 799.19 - Chemical imports and exports.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... CONTROL ACT (CONTINUED) IDENTIFICATION OF SPECIFIC CHEMICAL SUBSTANCE AND MIXTURE TESTING REQUIREMENTS... chemical substances or mixtures listed in subpart B, subpart C, or subpart D of this part are subject...

  8. 40 CFR 799.19 - Chemical imports and exports.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... CONTROL ACT (CONTINUED) IDENTIFICATION OF SPECIFIC CHEMICAL SUBSTANCE AND MIXTURE TESTING REQUIREMENTS... chemical substances or mixtures listed in subpart B, subpart C, or subpart D of this part are subject...

  9. 40 CFR 799.19 - Chemical imports and exports.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... CONTROL ACT (CONTINUED) IDENTIFICATION OF SPECIFIC CHEMICAL SUBSTANCE AND MIXTURE TESTING REQUIREMENTS... chemical substances or mixtures listed in subpart B, subpart C, or subpart D of this part are subject...

  10. 40 CFR 799.19 - Chemical imports and exports.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... CONTROL ACT (CONTINUED) IDENTIFICATION OF SPECIFIC CHEMICAL SUBSTANCE AND MIXTURE TESTING REQUIREMENTS... chemical substances or mixtures listed in subpart B, subpart C, or subpart D of this part are subject...

  11. The ACTS multibeam antenna

    NASA Technical Reports Server (NTRS)

    Regier, Frank A.

    1992-01-01

    The Advanced Communications Technology Satellite (ACTS) to be launched in 1993 is briefly introduced. Its multibeam antenna, consisting of electrically similar 30 GHz receive and 20 GHz transmit offset Cassegrain systems, both utilizing orthogonal polarizations, is described. Dual polarization is achieved by using one feed assembly for each polarization in conjunction with nested front and back subreflectors, the gridded front subreflector acting as a window for one polarization and a reflector for the other. The antennas produce spot beams with approximately 0.3 degree beamwidth and gains of approximately 50 dbi. High surface accuracy and high edge taper produce low sidelobe levels and high cross-polarization isolation. A brief description is given of several Ka-band components fabricated for ACTS. These include multiflare antenna feedhorns, beam-forming networks utilizing latching ferrite waveguide switches, a 30 GHz HEMT low-noise amplifier and a 20 GHz TWT power amplifier.

  12. The ACTS multibeam antenna

    NASA Astrophysics Data System (ADS)

    Regier, Frank A.

    1992-06-01

    The Advanced Communications Technology Satellite (ACTS) to be launched in 1993 is briefly introduced. Its multibeam antenna, consisting of electrically similar 30 GHz receive and 20 GHz transmit offset Cassegrain systems, both utilizing orthogonal polarizations, is described. Dual polarization is achieved by using one feed assembly for each polarization in conjunction with nested front and back subreflectors, the gridded front subreflector acting as a window for one polarization and a reflector for the other. The antennas produce spot beams with approximately 0.3 degree beamwidth and gains of approximately 50 dbi. High surface accuracy and high edge taper produce low sidelobe levels and high cross-polarization isolation. A brief description is given of several Ka-band components fabricated for ACTS. These include multiflare antenna feedhorns, beam-forming networks utilizing latching ferrite waveguide switches, a 30 GHz HEMT low-noise amplifier and a 20 GHz TWT power amplifier.

  13. [Chemical weapons and chemical terrorism].

    PubMed

    Nakamura, Katsumi

    2005-10-01

    Chemical Weapons are kind of Weapons of Mass Destruction (WMD). They were used large quantities in WWI. Historically, large quantities usage like WWI was not recorded, but small usage has appeared now and then. Chemical weapons are so called "Nuclear weapon for poor countrys" because it's very easy to produce/possession being possible. They are categorized (1) Nerve Agents, (2) Blister Agents, (3) Cyanide (blood) Agents, (4) Pulmonary Agents, (5) Incapacitating Agents (6) Tear Agents from the viewpoint of human body interaction. In 1997 the Chemical Weapons Convention has taken effect. It prohibits chemical weapons development/production, and Organization for the Prohibition of Chemical Weapons (OPCW) verification regime contributes to the chemical weapons disposal. But possibility of possession/use of weapons of mass destruction by terrorist group represented in one by Matsumoto and Tokyo Subway Sarin Attack, So new chemical terrorism countermeasures are necessary.

  14. Affordable Care Act.

    PubMed

    Rak, Sofija; Coffin, Janis

    2013-01-01

    The Patient Protection and Affordable Care Act of 2010 (PPACA), although a subject of much debate in the Unites States, was enacted on March 23, 2010, and upheld by the Supreme Court on June 28, 2012. This act advocates that "healthcare is a right, not a privilege." The main goals of PPACA are to minimize the number of uninsured Americans and make healthcare available to everyone at an affordable price. The Congressional Budget Office has determined that 94% of Americans will have healthcare coverage while staying under the $900 billion limit that President Barack Obama established by bending the healthcare cost curve and reducing the deficit over the next 10 years.

  15. Thyroid disrupting chemicals: Mechanisms and mixtures

    EPA Science Inventory

    Environmental contaminants are known to act as thyroid disrupting chemicals (TDCs). Broadly defined, TDCs are xenobiotics that alter the structure or function of the thyroid gland, alter regulatory enzymes associated with thyroid hormone (TH) homeostasis, or change circulating o...

  16. Chemical microsensors

    SciTech Connect

    Li, DeQuan; Swanson, Basil I.

    1995-01-01

    An article of manufacture is provided including a substrate having an oxide surface layer and a selective thin film of a cyclodextrin derivative chemically bound upon said substrate, said film is adapted for the inclusion of a selected organic compound therewith. Such an article can be either a chemical sensor capable of detecting a resultant mass change from inclusion of the selected organic compound or a chemical separator capable of reversibly selectively separating a selected organic compound.

  17. 77 FR 5100 - Certain New Chemicals; Receipt and Status Information

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ... application for a test marketing exemption (TME), and to publish in the Federal Register periodic status.... Section 5(h)(1) of TSCA authorizes EPA to allow persons, upon application, to manufacture (includes import... the Federal Register a notice of receipt of a PMN or an application for a TME and to publish in...

  18. 78 FR 11871 - Certain New Chemicals; Receipt and Status Information

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-20

    ... Register a notice of receipt of a premanufacture notice (PMN) or an application for a test marketing.... Section 5(h)(1) of TSCA authorizes EPA to allow persons, upon application, to manufacture (includes import... in the Federal Register a notice of receipt of a PMN or an application for a TME and to publish...

  19. 77 FR 10512 - Certain New Chemicals; Receipt and Status Information

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-22

    ... application for a test marketing exemption (TME), and to publish in the Federal Register periodic status... initiating the activity. Section 5(h)(1) of TSCA authorizes EPA to allow persons, upon application, to...), EPA is required to publish in the Federal Register a notice of receipt of a PMN or an application...

  20. 76 FR 69723 - Certain New Chemicals; Receipt and Status Information

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-09

    ... application for a test marketing exemption (TME), and to publish in the Federal Register periodic status.... Section 5(h)(1) of TSCA authorizes EPA to allow persons, upon application, to manufacture (includes import... in the Federal Register a notice of receipt of a PMN or an application for a TME and to publish...

  1. 77 FR 22780 - Certain New Chemicals; Receipt and Status Information

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-17

    ... application for a test marketing exemption (TME), and to publish in the Federal Register periodic status... initiating the activity. Section 5(h)(1) of TSCA authorizes EPA to allow persons, upon application, to...), EPA is required to publish in the Federal Register a notice of receipt of a PMN or an application...

  2. 75 FR 60447 - Certain New Chemicals; Receipt and Status Information

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-30

    ... receipt of a premanufacture notice (PMN) or an application for a test marketing exemption (TME), and to...)(2) and 5(d)(3) of TSCA, EPA is required to publish a notice of receipt of a PMN or an application... use ester. P-10-0428 06/22/10 09/19/10 CBI (G) Open, non- (S) 1-hexane, polymer dispersive use as...

  3. 78 FR 28586 - Certain New Chemicals; Receipt and Status Information

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-15

    ... Register a notice of receipt of a premanufacture notice (PMN) or an application for a test marketing... TSCA authorizes EPA to allow persons, upon application, to manufacture (includes import) or process a... Federal Register a notice of receipt of a PMN or an application for a TME and to publish in the...

  4. 77 FR 5091 - Certain New Chemicals; Receipt and Status Information

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ... with 2,2- applications; a polymer for dimethyl-1,3-propanediol, pigment and or ink diethylamine, 1,2... premanufacture notice (PMN) or an application for a test marketing exemption (TME), and to publish in the Federal.... Section 5(h)(1) of TSCA authorizes EPA to allow persons, upon application, to manufacture (includes...

  5. 77 FR 61600 - Certain New Chemicals; Receipt and Status Information

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-10

    ..., Inc. organic polymer. dimethylethyl)-4- hydroxy-, 2- ethylhexyl ester. P-12-0542........ 09/04/2012 12... Register a notice of receipt of a premanufacture notice (PMN) or an application for a test marketing... TSCA authorizes EPA to allow persons, upon application, to manufacture (includes import) or process...

  6. 77 FR 24705 - Certain New Chemicals; Receipt and Status Information

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ... application for a test marketing exemption (TME), and to publish in the Federal Register periodic status.... Section 5(h)(1) of TSCA authorizes EPA to allow persons, upon application, to manufacture (includes import... the Federal Register a notice of receipt of a PMN or an application for a TME and to publish in...

  7. Long-Chain Perfluorinated Chemicals (PFCs) Action Plan

    EPA Pesticide Factsheets

    This Action Plan is based on EPA’s initial review of readily available use, exposure, and hazard information on PFCs. EPA considered which of the various authorities provided under TSCA and other statutes might be appropriate to address potential concerns.

  8. The Kentucky Civil Rights Act: Explanation, the Act, Regulations.

    ERIC Educational Resources Information Center

    Kentucky State Commission on Human Rights, Frankfort.

    The Kentucky Civil Rights Act, introduced on January 4, 1966, enacted January 27, 1966 and effective July 1, 1966 is said to meet the requirements of the Federal Civil Rights Act of 1964. In 1968, the Act was amended to prohibit housing discrimination. In 1972, the coverage of the Act was extended to prohibit employment discrimination because of…

  9. The USA PATRIOT Act.

    ERIC Educational Resources Information Center

    Minow, Mary; Coyle, Karen; Kaufman, Paula

    2002-01-01

    Explains the USA PATRIOT (Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism) Act, passed after the September 11 terrorist attacks, and its implications for libraries and patron records. Considers past dealings with the FBI; court orders; search warrants; wiretaps; and subpoenas. Includes:…

  10. The Equal Access Act.

    ERIC Educational Resources Information Center

    Catron, J. Gregory

    1987-01-01

    Reviews past history of access of religious activities in public schools in relation to the establishment clause of the First Amendment and sets forth the prerequisites in the Equal Access Act of 1984 for creating a well-defined forum for student-initiated free speech including religious groups in public high schools. (MD)

  11. Special Appropriation Act Projects

    EPA Pesticide Factsheets

    EPA is sometimes directed to provide funding to a specific entity for study, purpose, or activity.This information will be of interest to a community or other entity that has been identified in one of EPA's appropriations acts to receive such funding.

  12. Job Training Partnership Act.

    ERIC Educational Resources Information Center

    Tindall, Lloyd W.; Hedberg, Sally B.

    1987-01-01

    The Job Training Partnership Act, which provides money to programs preparing disadvantaged (including disabled) individuals for entry into the labor force, has helped special education students in such programs as the Special Education Local Plan Areas Job Project and the Day Training Activity Center at the Las Trampas School, Inc. in Lafayette,…

  13. Acting like a Pro

    ERIC Educational Resources Information Center

    Walker, Marlon A.

    2012-01-01

    The Saturday morning acting class in the Pearson Hall auditorium at Miles College boasts the school's highest attendance all year. The teacher, actress Robin Givens, was a lure few students--and others from surrounding areas--could resist. Some came to learn about their prospective field from a professional. Others were there for pointers to…

  14. ACTS Mobile Terminals

    NASA Technical Reports Server (NTRS)

    Abbe, Brian S.; Agan, Martin J.; Jedrey, Thomas C.

    1997-01-01

    The development of the Advanced Communications Technology Satellite (ACTS) Mobile Terminal (AMT) and its follow-on, the Broadband Aeronautical Terminal (BAT), have provided an excellent testbed for the evaluation of K- and Ka-band mobile satellite communications systems. An overview of both of these terminals is presented in this paper.

  15. Improving America's Schools Act

    NASA Technical Reports Server (NTRS)

    Cradler, John; Bridgforth, Elizabeth

    1995-01-01

    The Improving America's Schools ACT (IASA) emphasizes coherent systemic education reform, with Goals 2000 setting common standards for IASA and the recently authorized School-to-Work Program. IASA addresses the need to raise academic achievement, increase opportunities to learn, improve professional development, increase community involvement, utilize instructional applications of technology, and improve assessment, and allow more local flexibility in the use of funds.

  16. Biological and Chemical Security

    SciTech Connect

    Fitch, P J

    2002-12-19

    The LLNL Chemical & Biological National Security Program (CBNP) provides science, technology and integrated systems for chemical and biological security. Our approach is to develop and field advanced strategies that dramatically improve the nation's capabilities to prevent, prepare for, detect, and respond to terrorist use of chemical or biological weapons. Recent events show the importance of civilian defense against terrorism. The 1995 nerve gas attack in Tokyo's subway served to catalyze and focus the early LLNL program on civilian counter terrorism. In the same year, LLNL began CBNP using Laboratory-Directed R&D investments and a focus on biodetection. The Nunn-Lugar-Domenici Defense Against Weapons of Mass Destruction Act, passed in 1996, initiated a number of U.S. nonproliferation and counter-terrorism programs including the DOE (now NNSA) Chemical and Biological Nonproliferation Program (also known as CBNP). In 2002, the Department of Homeland Security was formed. The NNSA CBNP and many of the LLNL CBNP activities are being transferred as the new Department becomes operational. LLNL has a long history in national security including nonproliferation of weapons of mass destruction. In biology, LLNL had a key role in starting and implementing the Human Genome Project and, more recently, the Microbial Genome Program. LLNL has over 1,000 scientists and engineers with relevant expertise in biology, chemistry, decontamination, instrumentation, microtechnologies, atmospheric modeling, and field experimentation. Over 150 LLNL scientists and engineers work full time on chemical and biological national security projects.

  17. 40 CFR 766.38 - Reporting on precursor chemical substances.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Reporting on precursor chemical... SUBSTANCES CONTROL ACT DIBENZO-PARA-DIOXINS/DIBENZOFURANS Specific Chemical Testing/Reporting Requirements § 766.38 Reporting on precursor chemical substances. (a) Identification of precursor chemical...

  18. 40 CFR 766.38 - Reporting on precursor chemical substances.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Reporting on precursor chemical... SUBSTANCES CONTROL ACT DIBENZO-PARA-DIOXINS/DIBENZOFURANS Specific Chemical Testing/Reporting Requirements § 766.38 Reporting on precursor chemical substances. (a) Identification of precursor chemical...

  19. 40 CFR 766.38 - Reporting on precursor chemical substances.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Reporting on precursor chemical... SUBSTANCES CONTROL ACT DIBENZO-PARA-DIOXINS/DIBENZOFURANS Specific Chemical Testing/Reporting Requirements § 766.38 Reporting on precursor chemical substances. (a) Identification of precursor chemical...

  20. Chemical sensors

    DOEpatents

    Lowell, Jr., James R.; Edlund, David J.; Friesen, Dwayne T.; Rayfield, George W.

    1991-01-01

    Sensors responsive to small changes in the concentration of chemical species are disclosed, comprising (a) a mechanochemically responsive polymeric film capable of expansion or contraction in response to a change in its chemical environment, operatively coupled to (b) a transducer capable of directly converting said expansion or contraction to a measurable electrical response.

  1. Chemical preconcentrator

    DOEpatents

    Manginell, Ronald P.; Frye-Mason, Gregory C.

    2001-01-01

    A chemical preconcentrator is disclosed with applications to chemical sensing and analysis. The preconcentrator can be formed by depositing a resistive heating element (e.g. platinum) over a membrane (e.g. silicon nitride) suspended above a substrate. A coating of a sorptive material (e.g. a microporous hydrophobic sol-gel coating or a polymer coating) is formed on the suspended membrane proximate to the heating element to selective sorb one or more chemical species of interest over a time period, thereby concentrating the chemical species in the sorptive material. Upon heating the sorptive material with the resistive heating element, the sorbed chemical species are released for detection and analysis in a relatively high concentration and over a relatively short time period. The sorptive material can be made to selectively sorb particular chemical species of interest while not substantially sorbing other chemical species not of interest. The present invention has applications for use in forming high-sensitivity, rapid-response miniaturized chemical analysis systems (e.g. a "chem lab on a chip").

  2. Chemical pneumonitis

    MedlinePlus

    ... chemicals. Alternative Names Aspiration pneumonia - chemical Images Lungs Respiratory system References Blanc PD. Acute responses to toxic exposures. In: Broaddus VC, Mason RJ, Ernst JD, et al, eds. Murray and Nadel's Textbook of Respiratory Medicine . 6th ed. Philadelphia, PA: Elsevier Saunders; 2016: ...

  3. Fracturing Responsibility and Awareness of Chemicals (FRAC) Act

    THOMAS, 111th Congress

    Sen. Casey, Robert P., Jr. [D-PA

    2009-06-09

    06/09/2009 Read twice and referred to the Committee on Environment and Public Works. (text of measure as introduced: CR S6382) (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  4. Continuing Chemical Facilities Antiterrorism Security Act of 2010

    THOMAS, 111th Congress

    Rep. Dent, Charles W. [R-PA-15

    2010-04-29

    05/05/2010 Referred to the Subcommittee on Transportation Security and Infrastructure Protection. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  5. Protecting Communities from Chemical Explosions Act of 2013

    THOMAS, 113th Congress

    Sen. Lautenberg, Frank R. [D-NJ

    2013-04-25

    04/25/2013 Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  6. Continuing Chemical Facilities Antiterrorism Security Act of 2011

    THOMAS, 112th Congress

    Sen. Collins, Susan M. [R-ME

    2011-03-03

    10/20/2011 By Senator Lieberman from Committee on Homeland Security and Governmental Affairs filed written report. Report No. 112-90. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  7. 77 FR 59891 - Proposed Information Collection; Comment Request; Chemical Weapons Convention Declaration and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... Bureau of Industry and Security Proposed Information Collection; Comment Request; Chemical Weapons...@bis.doc.gov . SUPPLEMENTARY INFORMATION: ] I. Abstract The Chemical Weapons Convention Implementation Act of 1998 and Commerce Chemical Weapons Convention Regulations (CWCR) specify the...

  8. ACTS of Education

    NASA Technical Reports Server (NTRS)

    Bauer, Robert; Krawczyk, Richard; Gargione, Frank; Kruse, Hans; Vrotsos, Pete (Technical Monitor)

    2002-01-01

    Now in its ninth year of operations, the Advanced Communications Technology Satellite (ACTS) program has continued, although since May 2000 in a new operations arrangement involving a university based consortium, the Ohio Consortium for Advanced Communications Technology (OCACT), While NASA has concluded its experimental intentions of ACTS, the spacecraft's ongoing viability has permitted its further operations to provide educational opportunities to engineering and communications students interested in satellite operations, as well as a Ka-band test bed for commercial interests in utilizing Kaband space communications. The consortium has reached its first year of operations. This generous opportunity by NASA has already resulted in unique educational opportunities for students in obtaining "hands-on" experience, such as, in satellite attitude control. An update is presented on the spacecraft and consortium operations.

  9. Systematic chemical-genetic and chemical-chemical interaction datasets for prediction of compound synergism

    PubMed Central

    Wildenhain, Jan; Spitzer, Michaela; Dolma, Sonam; Jarvik, Nick; White, Rachel; Roy, Marcia; Griffiths, Emma; Bellows, David S.; Wright, Gerard D.; Tyers, Mike

    2016-01-01

    The network structure of biological systems suggests that effective therapeutic intervention may require combinations of agents that act synergistically. However, a dearth of systematic chemical combination datasets have limited the development of predictive algorithms for chemical synergism. Here, we report two large datasets of linked chemical-genetic and chemical-chemical interactions in the budding yeast Saccharomyces cerevisiae. We screened 5,518 unique compounds against 242 diverse yeast gene deletion strains to generate an extended chemical-genetic matrix (CGM) of 492,126 chemical-gene interaction measurements. This CGM dataset contained 1,434 genotype-specific inhibitors, termed cryptagens. We selected 128 structurally diverse cryptagens and tested all pairwise combinations to generate a benchmark dataset of 8,128 pairwise chemical-chemical interaction tests for synergy prediction, termed the cryptagen matrix (CM). An accompanying database resource called ChemGRID was developed to enable analysis, visualisation and downloads of all data. The CGM and CM datasets will facilitate the benchmarking of computational approaches for synergy prediction, as well as chemical structure-activity relationship models for anti-fungal drug discovery. PMID:27874849

  10. Systematic chemical-genetic and chemical-chemical interaction datasets for prediction of compound synergism.

    PubMed

    Wildenhain, Jan; Spitzer, Michaela; Dolma, Sonam; Jarvik, Nick; White, Rachel; Roy, Marcia; Griffiths, Emma; Bellows, David S; Wright, Gerard D; Tyers, Mike

    2016-11-22

    The network structure of biological systems suggests that effective therapeutic intervention may require combinations of agents that act synergistically. However, a dearth of systematic chemical combination datasets have limited the development of predictive algorithms for chemical synergism. Here, we report two large datasets of linked chemical-genetic and chemical-chemical interactions in the budding yeast Saccharomyces cerevisiae. We screened 5,518 unique compounds against 242 diverse yeast gene deletion strains to generate an extended chemical-genetic matrix (CGM) of 492,126 chemical-gene interaction measurements. This CGM dataset contained 1,434 genotype-specific inhibitors, termed cryptagens. We selected 128 structurally diverse cryptagens and tested all pairwise combinations to generate a benchmark dataset of 8,128 pairwise chemical-chemical interaction tests for synergy prediction, termed the cryptagen matrix (CM). An accompanying database resource called ChemGRID was developed to enable analysis, visualisation and downloads of all data. The CGM and CM datasets will facilitate the benchmarking of computational approaches for synergy prediction, as well as chemical structure-activity relationship models for anti-fungal drug discovery.

  11. Toxic Substances Control Act

    SciTech Connect

    Not Available

    1992-05-15

    This Reference Book contains a current copy of the Toxic Substances Control Act and those regulations that implement the statute and appear to be most relevant to DOE activities. The document is provided to DOE and contractor staff for informational purposes only and should not be interpreted as legal guidance. Questions concerning this Reference Book may be directed to Mark Petts, EH-231 (202/586-2609).

  12. ACTE Wing Loads Analysis

    NASA Technical Reports Server (NTRS)

    Horn, Nicholas R.

    2015-01-01

    The Adaptive Compliant Trailing Edge (ACTE) project modified a Gulfstream III (GIII) aircraft with a new flexible flap that creates a seamless transition between the flap and the wing. As with any new modification, it is crucial to ensure that the aircraft will not become overstressed in flight. To test this, Star CCM a computational fluid dynamics (CFD) software program was used to calculate aerodynamic data for the aircraft at given flight conditions.

  13. Freedom of Information Act

    USGS Publications Warehouse

    Newman, D.J.

    2012-01-01

    The Freedom of Information Act( FOIA), 5 U.S.C.§ 552, as amended, generally provides that any person has a right to request access to Federal agency records. The USGS proactively promotes information disclosure as inherent to its mission of providing objective science to inform decisionmakers and the general public. USGS scientists disseminate up-to-date and historical scientific data that are critical to addressing national and global priorities.

  14. The ACTS multibeam antenna

    NASA Technical Reports Server (NTRS)

    Regier, Frank A.

    1992-01-01

    The Advanced Communications Technology Satellite (ACTS) to be launched in 1993 introduces several new technologies including a multibeam antenna (MBA) operating at Ka-band. The satellite is introduced briefly, and then the MBA, consisting of electrically similar 30 GHz received and 20 GHz transmit offset Cassegrain systems utilizing orthogonal linear polarizations, is described. Dual polarization is achieved by using one feed assembly for each polarization in conjunction with nested front and back subreflectors, the gridded front subreflector acting as a window for one polarization and a reflector for the other. The antennas produce spot beams with approximately 0.3 deg beamwidth and gains of approximately 50 dbi. High surface accuracy and high edge taper produce low sidelobe levels and high cross-polarization isolation. A brief description is given of several Ka-band components fabricated for ACTS. These include multiflare antenna feedhorns, beam-forming networks utilizing latching ferrite waveguide switches, a 30 GHz high mobility electron transmitter (HEMT) low-noise amplifier and a 20 GHz TWT power amplifier.

  15. The ACTS multibeam antenna

    NASA Astrophysics Data System (ADS)

    Regier, Frank A.

    1992-04-01

    The Advanced Communications Technology Satellite (ACTS) to be launched in 1993 introduces several new technologies including a multibeam antenna (MBA) operating at Ka-band. The satellite is introduced briefly, and then the MBA, consisting of electrically similar 30 GHz received and 20 GHz transmit offset Cassegrain systems utilizing orthogonal linear polarizations, is described. Dual polarization is achieved by using one feed assembly for each polarization in conjunction with nested front and back subreflectors, the gridded front subreflector acting as a window for one polarization and a reflector for the other. The antennas produce spot beams with approximately 0.3 deg beamwidth and gains of approximately 50 dbi. High surface accuracy and high edge taper produce low sidelobe levels and high cross-polarization isolation. A brief description is given of several Ka-band components fabricated for ACTS. These include multiflare antenna feedhorns, beam-forming networks utilizing latching ferrite waveguide switches, a 30 GHz high mobility electron transmitter (HEMT) low-noise amplifier and a 20 GHz TWT power amplifier.

  16. Unnecessary Chemicals

    ERIC Educational Resources Information Center

    Johnson, Anita

    1978-01-01

    Discusses the health hazards resulting from chemical additions of many common products such as cough syrups, food dyes, and cosmetics. Steps being taken to protect consumers from these health hazards are included. (MDR)

  17. Chemical sensors

    DOEpatents

    Lowell, J.R. Jr.; Edlund, D.J.; Friesen, D.T.; Rayfield, G.W.

    1992-06-09

    Sensors responsive to small changes in the concentration of chemical species are disclosed, comprising a mechanicochemically responsive polymeric film capable of expansion or contraction in response to a change in its chemical environment, either operatively coupled to a transducer capable of directly converting the expansion or contraction to a measurable electrical or optical response, or adhered to a second inert polymeric strip, or doped with a conductive material. 12 figs.

  18. Chemical sensors

    DOEpatents

    Lowell, Jr., James R.; Edlund, David J.; Friesen, Dwayne T.; Rayfield, George W.

    1992-01-01

    Sensors responsive to small changes in the concentration of chemical species are disclosed, comprising a mechanicochemically responsive polymeric film capable of expansion or contraction in response to a change in its chemical environment, either operatively coupled to a transducer capable of directly converting the expansion or contraction to a measurable electrical or optical response, or adhered to a second inert polymeric strip, or doped with a conductive material.

  19. Chemical carcinogenesis.

    PubMed

    Oliveira, Paula A; Colaço, Aura; Chaves, Raquel; Guedes-Pinto, Henrique; De-La-Cruz P, Luis F; Lopes, Carlos

    2007-12-01

    The use of chemical compounds benefits society in a number of ways. Pesticides, for instance, enable foodstuffs to be produced in sufficient quantities to satisfy the needs of millions of people, a condition that has led to an increase in levels of life expectancy. Yet, at times, these benefits are offset by certain disadvantages, notably the toxic side effects of the chemical compounds used. Exposure to these compounds can have varying effects, ranging from instant death to a gradual process of chemical carcinogenesis. There are three stages involved in chemical carcinogenesis. These are defined as initiation, promotion and progression. Each of these stages is characterised by morphological and biochemical modifications and result from genetic and/or epigenetic alterations. These genetic modifications include: mutations in genes that control cell proliferation, cell death and DNA repair--i.e. mutations in proto-oncogenes and tumour suppressing genes. The epigenetic factors, also considered as being non-genetic in character, can also contribute to carcinogenesis via epigenetic mechanisms which silence gene expression. The control of responses to carcinogenesis through the application of several chemical, biochemical and biological techniques facilitates the identification of those basic mechanisms involved in neoplasic development. Experimental assays with laboratory animals, epidemiological studies and quick tests enable the identification of carcinogenic compounds, the dissection of many aspects of carcinogenesis, and the establishment of effective strategies to prevent the cancer which results from exposure to chemicals.

  20. Emergency Planning and Community Right-to-Know Act (EPCRA) requirements. CERCLA Information Brief

    SciTech Connect

    Dailey, R.

    1993-10-01

    The Emergency Planning and Community Right-to-Know Act (EPCRA), also known as Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA), requires regulated facilities to publicly disclose information about the chemicals they store, use, dispose of, or release. The information is used to encourage and support emergency planning for responding to chemical accidents and to provide local governments and the public with information about possible chemical hazards in their communities.

  1. Tautomerism in chemical information management systems

    NASA Astrophysics Data System (ADS)

    Warr, Wendy A.

    2010-06-01

    Tautomerism has an impact on many of the processes in chemical information management systems including novelty checking during registration into chemical structure databases; storage of structures; exact and substructure searching in chemical structure databases; and depiction of structures retrieved by a search. The approaches taken by 27 different software vendors and database producers are compared. It is hoped that this comparison will act as a discussion document that could ultimately improve databases and software for researchers in the future.

  2. ACTS broadband aeronautical experiment

    NASA Technical Reports Server (NTRS)

    Abbe, Brian S.; Jedrey, Thomas C.; Estabrook, Polly; Agan, Martin J.

    1993-01-01

    In the last decade, the demand for reliable data, voice, and video satellite communication links between aircraft and ground to improve air traffic control, airline management, and to meet the growing demand for passenger communications has increased significantly. It is expected that in the near future, the spectrum required for aeronautical communication services will grow significantly beyond that currently available at L-band. In anticipation of this, JPL is developing an experimental broadband aeronautical satellite communications system that will utilize NASA's Advanced Communications Technology Satellite (ACTS) as a satellite of opportunity and the technology developed under JPL's ACTS Mobile Terminal (AMT) Task to evaluate the feasibility of using K/Ka-band for these applications. The application of K/Ka-band for aeronautical satellite communications at cruise altitudes is particularly promising for several reasons: (1) the minimal amount of signal attenuation due to rain; (2) the reduced drag due to the smaller K/Ka-band antennas (as compared to the current L-band systems); and (3) the large amount of available bandwidth. The increased bandwidth available at these frequencies is expected to lead to significantly improved passenger communications - including full-duplex compressed video and multiple channel voice. A description of the proposed broadband experimental system will be presented including: (1) applications of K/Ka-band aeronautical satellite technology to U.S. industry; (2) the experiment objectives; (3) the experiment set-up; (4) experimental equipment description; and (5) industrial participation in the experiment and the benefits.

  3. Vaccination: An Act of Love

    MedlinePlus

    ... dreams. Remember too: Vaccination is an Act of Love. Dr. Mirta Roses Periago Director, Pan American Health ... MICROSCOPE ? KNOW WHY VACCINATION IS AN ACT OF LOVE? IT PROTECTS AGAINST MANY TYPES OF DISEASE! AND ...

  4. The Nurse Reinvestment Act revisited.

    PubMed

    Luther, Ann P

    2007-01-01

    The United States is in the midst of a widely recognized critical nursing shortage. In 2002 the "Nurse Reinvestment Act" was passed with overwhelming bipartisan support in an effort to address this serious public health threat. The Act is due for reauthorization of funding in 2007. This paper provides a brief overview of the programs contained within the Act and describes practical ways in which members of the nursing community can take action to insure renewed support for the Act.

  5. ITC-CMA partnership and data needs for alkylphenols and ethoxylates

    USGS Publications Warehouse

    Rattner, B.A.; Rice, C.P.; Walker, J.D.

    1996-01-01

    The ITC has been an independent advisory committee to the EPA Administrator since enactment of the Toxics Substances Control Act (TSCA) in 1976. The ITC identifies and coordinates U.S. Government data needs for TSCA-regulable chemicals, and makes recommendations to the Administrator for priority testing consideration. Chemicals recommended by the ITC are added to the TSCA Priority Testing List that is revised semi-annually in Reports to the Administrator. In recent Reports, the ITC added alkylphenols (APs) and ethoxylates to the Priority Testing List. About 500 million pounds are produced annually for industrial processing, cleaning and personal care products. APs have been detected in the tissues of fish from the Great Lakes, and one AP (nonylphenol) causes vitellogenin gene expression in trout hepatocytes. Numerous APs and ethoxylates were recommended by the ITC because data are needed on: (1) chemical composition, (2) environmental fate of parent chemicals and impurities, and (3) health and ecological effects (including toxicokinetics and endocrine-modulating effects). In response to the ITC's recommendations, two activities have ensued. First, the EPA promulgated rules requiring manufacturers, importers and processors of APs and ethoxylates to submit production and exposure reports, and unpublished health and safety studies, for review. Second, the Alkylphenols and Ethoxylates Panel of Chemical Manufacturers Association (CMA) and the ITC formed a Dialogue Group to discuss the data needs. Data needs and activities initiated by the Dialogue Group will be presented.

  6. FCC and the Sunshine Act.

    ERIC Educational Resources Information Center

    Weiss, Kenneth

    The Sunshine Act, designed to encourage open meetings to increase public understanding of the governmental decision-making process, went into effect in March 1977. A total of 50 agencies, including the Federal Communications Commission (FCC), are subject to the provisions of the Sunshine Act. The act lists 10 exemptions, any of which can result in…

  7. Guidance on the management of polychlorinated biphenyls (PCBs)

    SciTech Connect

    Not Available

    1993-11-01

    Polychlorinated biphenyls (PCBs) are a class of synthetic organic chemicals including 209 known isomers, each with from 1 to 10 chlorine atoms on a biphenyl ring. PCBs have a number of desirable properties for industrial applications including thermal stability, flame retardance, and low vapor pressure. Because of these properties, PCBs were widely used as dielectric fluid in electrical equipment such as utility transformers and capacitors. PCBs were also extensively used in hydraulic fluid and heat transfer fluid, in gaskets, as additives in cutting oils and lubricant, and in a variety of other uses. The Toxic Substances Control Act (TSCA) banned the manufacture of PCBs after 1978 in response to emerging information about the adverse health effects of PCBs and their persistence in the environment. In addition, TSCA directed the Administrator of the Environmental Protection Agency (EPA) to prescribe methods for disposal of PCBS, require marking of PCBs with warning labels, and control their use. The TSCA regulations allow continued use of PCBs provided that the use is totally enclosed and does not pose a risk to human health or the environment. However, at the end of their useful life, all PCB materials must be disposed of according to the TSCA regulations. This guidance document uses graphics and flow charts where possible to present the TSCA regulations according to management activities such as use, storage, disposal, and spill cleanup. The document is designed to be read on an as-needed basis; that is, each chapter can stand alone or may be read in combination with others to help the reader determine the regulations relevant to his or her individual situation and needs. Every attempt has been made to include the requirements of other statutes and regulations that apply to PCB materials and provide references for the reader to consult for additional information.

  8. FAST ACTING CURRENT SWITCH

    DOEpatents

    Batzer, T.H.; Cummings, D.B.; Ryan, J.F.

    1962-05-22

    A high-current, fast-acting switch is designed for utilization as a crowbar switch in a high-current circuit such as used to generate the magnetic confinement field of a plasma-confining and heat device, e.g., Pyrotron. The device particularly comprises a cylindrical housing containing two stationary, cylindrical contacts between which a movable contact is bridged to close the switch. The movable contact is actuated by a differential-pressure, airdriven piston assembly also within the housing. To absorb the acceleration (and the shock imparted to the device by the rapidly driven, movable contact), an adjustable air buffer assembly is provided, integrally connected to the movable contact and piston assembly. Various safety locks and circuit-synchronizing means are also provided to permit proper cooperation of the invention and the high-current circuit in which it is installed. (AEC)

  9. ACTS mobile propagation campaign

    NASA Technical Reports Server (NTRS)

    Goldhirsh, Julius; Vogel, Wolfhard J.; Torrence, Geoffrey W.

    1994-01-01

    Preliminary results are presented for three propagation measurement campaigns involving a mobile receiving laboratory and 20 GHz transmissions from the Advanced Communications Technology Satellite (ACTS). Four 1994 campaigns were executed during weekly periods in and around Austin, Texas in February and May, in Central Maryland during March, and in Fairbanks, Alaska and environs in June. Measurements tested the following effects at 20 GHz: (1) attenuation due to roadside trees with and without foliage, (2) multipath effects for scenarios in which line-of-sight paths were unshadowed, (3) fades due to terrain and roadside obstacles, (4) fades due to structures in urban environs, (5) single tree attenuation, and (6) effects of fading at low elevation angles (8 deg in Fairbanks, Alaska) and high elevation angles (55 deg in Austin, Texas). Results presented here cover sampled measurements in Austin, Texas for foliage and non-foliage cases and in Central Maryland for non-foliage runs.

  10. Federal Employees' Compensation Act.

    PubMed

    Ladou, Joseph

    2009-01-01

    The Federal Employees' Compensation Act (FECA) program provides wage loss compensation and payments for medical treatment to federal civilian employees. Administered by the Department of Labor (DOL), FECA covers over 2.7 million federal employees in more than 70 different agencies. FECA costs rose from $1.4 billion in 1990 to $2.6 in 2006, while the federal workforce remained essentially unchanged. While federal civilian employees represent only 2.1% of all workers eligible for workers' compensation benefits, federal programs account for 6% of the benefits paid. Disability benefits under FECA are far greater than those in the state workers' compensation programs. The benefit payments often exceed the former salary of the injured employee. The last congressional hearings on the FECA program were held over thirty years ago. It is unlikely that Congressional review will occur any time soon, as the entrenched bureaucracy that benefits from the FECA program defines and protects its future.

  11. Triple acting radial seal

    SciTech Connect

    Ebert, Todd A; Carella, John A

    2012-03-13

    A triple acting radial seal used as an interstage seal assembly in a gas turbine engine, where the seal assembly includes an interstage seal support extending from a stationary inner shroud of a vane ring, the interstage seal support includes a larger annular radial inward facing groove in which an outer annular floating seal assembly is secured for radial displacement, and the outer annular floating seal assembly includes a smaller annular radial inward facing groove in which an inner annular floating seal assembly is secured also for radial displacement. A compliant seal is secured to the inner annular floating seal assembly. The outer annular floating seal assembly encapsulates the inner annular floating seal assembly which is made from a very low alpha material in order to reduce thermal stress.

  12. Delicious Chemicals.

    ERIC Educational Resources Information Center

    Barry, Dana M.

    This paper presents an approach to chemistry and nutrition that focuses on food items that people consider delicious. Information is organized according to three categories of food chemicals that provide energy to the human body: (1) fats and oils; (2) carbohydrates; and (3) proteins. Minerals, vitamins, and additives are also discussed along with…

  13. Chemical Mahjong

    ERIC Educational Resources Information Center

    Cossairt, Travis J.; Grubbs, W. Tandy

    2011-01-01

    An open-access, Web-based mnemonic game is described whereby introductory chemistry knowledge is tested using mahjong solitaire game play. Several tile sets and board layouts are included that are themed upon different chemical topics. Introductory tile sets can be selected that prompt the player to match element names to symbols and metric…

  14. Approaches to Estimate Consumer Exposure under TSCA

    EPA Pesticide Factsheets

    CEM contains a combination of models and default parameters which are used to estimate inhalation, dermal, and oral exposures to consumer products and articles for a wide variety of product and article use categories.

  15. 40 CFR 799.9780 - TSCA immunotoxicity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... examined. (E) Spleen cell viability shall be determined. (F) The numbers of IgM PFC per spleen, and the... YAC-1 lymphoma cells may be appropriate for use in the assay. In all cases, target cell viability... B cells in response to antigens, and bind specifically to the eliciting antigen. The...

  16. 40 CFR 799.9420 - TSCA carcinogenicity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... follows: (A) Gross criteria for reaching the high dose: (1) Erythema (moderate). (2) Scaling. (3) Edema...) Fibrosis. (6) Spongiosis (minimal-mild). (7) Epidermal edema (minimal-mild). (8) Dermal edema (minimal.... (3) Degeneration/necrosis (mild to moderate). (4) Epidermal edema (moderate to marked). (5)...

  17. 40 CFR 799.9420 - TSCA carcinogenicity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... follows: (A) Gross criteria for reaching the high dose: (1) Erythema (moderate). (2) Scaling. (3) Edema...) Fibrosis. (6) Spongiosis (minimal-mild). (7) Epidermal edema (minimal-mild). (8) Dermal edema (minimal.... (3) Degeneration/necrosis (mild to moderate). (4) Epidermal edema (moderate to marked). (5)...

  18. 40 CFR 799.9420 - TSCA carcinogenicity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... follows: (A) Gross criteria for reaching the high dose: (1) Erythema (moderate). (2) Scaling. (3) Edema...) Fibrosis. (6) Spongiosis (minimal-mild). (7) Epidermal edema (minimal-mild). (8) Dermal edema (minimal.... (3) Degeneration/necrosis (mild to moderate). (4) Epidermal edema (moderate to marked). (5)...

  19. 40 CFR 799.9420 - TSCA carcinogenicity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... follows: (A) Gross criteria for reaching the high dose: (1) Erythema (moderate). (2) Scaling. (3) Edema...) Fibrosis. (6) Spongiosis (minimal-mild). (7) Epidermal edema (minimal-mild). (8) Dermal edema (minimal.... (3) Degeneration/necrosis (mild to moderate). (4) Epidermal edema (moderate to marked). (5)...

  20. 40 CFR 799.9420 - TSCA carcinogenicity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... follows: (A) Gross criteria for reaching the high dose: (1) Erythema (moderate). (2) Scaling. (3) Edema...) Fibrosis. (6) Spongiosis (minimal-mild). (7) Epidermal edema (minimal-mild). (8) Dermal edema (minimal.... (3) Degeneration/necrosis (mild to moderate). (4) Epidermal edema (moderate to marked). (5)...

  1. 40 CFR 707.20 - Chemical substances import policy.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Chemical substances import policy. 707... SUBSTANCES CONTROL ACT CHEMICAL IMPORTS AND EXPORTS General Import Requirements and Restrictions § 707.20 Chemical substances import policy. (a) Scope. (1) This statement addresses the policy of the...

  2. 40 CFR 712.30 - Chemical lists and reporting periods.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Chemical lists and reporting periods. 712.30 Section 712.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT CHEMICAL INFORMATION RULES Manufacturers Reporting-Preliminary Assessment Information § 712.30 Chemical lists and...

  3. Pediatric considerations in chemical exposures: are we prepared?

    PubMed

    Lynch, Elizabeth Lea; Thomas, Tamara L

    2004-03-01

    Manmade disasters have risen over the past decaFde. Specifically, chemical weapons used in acts of aggression pose an increasing threat to our society. These potential disaster situations raise concerns regarding preparedness for both adults and children. This article's purpose is to review general principles of chemical exposure and treatment of specific chemical agents, and to identify specific pediatric considerations involved.

  4. Chemical warfare

    PubMed Central

    Samuels, Richard Ian; Mattoso, Thalles Cardoso; Moreira, Denise D.O.

    2013-01-01

    Leaf-cutting ants are well known for their highly complex social organization, which provides them with a strong defense against parasites invading their colonies. Besides this attribute, these insects have morphological, physiological and structural characteristics further reinforcing the defense of their colonies. With the discovery of symbiotic bacteria present on the integument of leaf-cutting ants, a new line of defense was proposed and considered to be specific for the control of a specialized fungal parasite of the ants’ fungus gardens (Escovopsis). However, recent studies have questioned the specificity of the integumental bacteria, as they were also found to inhibit a range of fungi, including entomopathogens. The microbiota associated with the leaf-cutting ant gardens has also been proposed as another level of chemical defense, protecting the garden from parasite invasion. Here we review the chemical defense weaponry deployed by leaf-cutting ants against parasites of their fungus gardens and of the ants themselves. PMID:23795235

  5. Fast-Acting Valve

    NASA Technical Reports Server (NTRS)

    Wojciechowski, Bogdan V. (Inventor); Pegg, Robert J. (Inventor)

    2003-01-01

    A fast-acting valve includes an annular valve seat that defines an annular valve orifice between the edges of the annular valve seat, an annular valve plug sized to cover the valve orifice when the valve is closed, and a valve-plug holder for moving the annular valve plug on and off the annular valve seat. The use of an annular orifice reduces the characteristic distance between the edges of the valve seat. Rather than this distance being equal to the diameter of the orifice, as it is for a conventional circular orifice, the characteristic distance equals the distance between the inner and outer radii (for a circular annulus). The reduced characteristic distance greatly reduces the gap required between the annular valve plug and the annular valve seat for the valve to be fully open, thereby greatly reducing the required stroke and corresponding speed and acceleration of the annular valve plug. The use of a valve-plug holder that is under independent control to move the annular valve plug between its open and closed positions is important for achieving controllable fast operation of the valve.

  6. Double acting bit holder

    DOEpatents

    Morrell, Roger J.; Larson, David A.; Ruzzi, Peter L.

    1994-01-01

    A double acting bit holder that permits bits held in it to be resharpened during cutting action to increase energy efficiency by reducing the amount of small chips produced. The holder consist of: a stationary base portion capable of being fixed to a cutter head of an excavation machine and having an integral extension therefrom with a bore hole therethrough to accommodate a pin shaft; a movable portion coextensive with the base having a pin shaft integrally extending therefrom that is insertable in the bore hole of the base member to permit the moveable portion to rotate about the axis of the pin shaft; a recess in the movable portion of the holder to accommodate a shank of a bit; and a biased spring disposed in adjoining openings in the base and moveable portions of the holder to permit the moveable portion to pivot around the pin shaft during cutting action of a bit fixed in a turret to allow front, mid and back positions of the bit during cutting to lessen creation of small chip amounts and resharpen the bit during excavation use.

  7. Long-acting progestogens.

    PubMed

    Affandi, Biran

    2002-04-01

    Steroids can be administered in at least five different ways: injectables; hormone-releasing intra-uterine devices (IUDs); implants; vaginal rings; and pills. Progestogens which are synthetic steroids, are used as the main bioactive substances. Different progestogens are effective for different periods of time. Progestins in daily oral pills are effective for 24 hours. The effectiveness of a progestogen can be prolonged by incorporating it in a sustained-release system that gradually releases the hormone; therefore they can be effective up to 5 years or more. Two progestogen-only injectables are widely available in the family planning programmes, (DMPA and NET-EN) and two combined injectables, Cyclofem (DMPA + EC), and Mesigyna (NET-EN + EV). The ring is placed by the woman in her vagina, where it gradually releases hormone. Implantable contraceptives are placed just under the skin on the inside of the woman's arm. Implant capsules release the progestogen at a slow, steady rate. There are three implantables available in the market: Implanon; Norplant; and Jadelle. They are effective for 1-5 years, but then must be replaced. Natural and synthetic progestogens were first added to IUDs in the early 1970s. The main problem of long-acting progestogens is the disruption of the menstrual cycle.

  8. Acting to gain information

    NASA Technical Reports Server (NTRS)

    Rosenchein, Stanley J.; Burns, J. Brian; Chapman, David; Kaelbling, Leslie P.; Kahn, Philip; Nishihara, H. Keith; Turk, Matthew

    1993-01-01

    This report is concerned with agents that act to gain information. In previous work, we developed agent models combining qualitative modeling with real-time control. That work, however, focused primarily on actions that affect physical states of the environment. The current study extends that work by explicitly considering problems of active information-gathering and by exploring specialized aspects of information-gathering in computational perception, learning, and language. In our theoretical investigations, we analyzed agents into their perceptual and action components and identified these with elements of a state-machine model of control. The mathematical properties of each was developed in isolation and interactions were then studied. We considered the complexity dimension and the uncertainty dimension and related these to intelligent-agent design issues. We also explored active information gathering in visual processing. Working within the active vision paradigm, we developed a concept of 'minimal meaningful measurements' suitable for demand-driven vision. We then developed and tested an architecture for ongoing recognition and interpretation of visual information. In the area of information gathering through learning, we explored techniques for coping with combinatorial complexity. We also explored information gathering through explicit linguistic action by considering the nature of conversational rules, coordination, and situated communication behavior.

  9. 75 FR 9900 - Agency Forms Undergoing Paperwork Reduction Act Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... should be received within 30 days of this notice. Proposed Project Laboratory Response Network (LRN...). Background and Brief Description The Laboratory Response Network (LRN) was established by the Department of... international network of laboratories that can respond to suspected acts of biological, chemical,...

  10. [Euthanasia and medical act].

    PubMed

    2011-05-01

    Right to life -as the prohibition of intentionally and arbitrarily taking life, even with authorization of the concerned one- is an internationally recognized right. In many countries, debate regarding euthanasia is more centered in its convenience, social acceptability and how it is regulated, than in its substantial legitimacy. Some argue that euthanasia should be included as part of clinical practice of health professionals, grounded on individual's autonomy claims-everyone having the liberty to choose how to live and how to die. Against this, others sustain that life has a higher value than autonomy, exercising autonomy without respecting the right to life would become a serious moral and social problem. Likewise, euthanasia supporters some-times claim a 'right to live with dignity', which must be understood as a personal obligation, referred more to the ethical than to the strictly legal sphere. In countries where it is already legalized, euthanasia practice has extended to cases where it is not the patient who requests this but the family or some healthcare professional, or even the legal system-when they think that the patient is living in a condition which is not worthy to live. Generalization of euthanasia possibly will end in affecting those who need more care, such as elder, chronically ill or dying people, damaging severely personal basic rights. Nature, purpose and tradition of medicine rule out the practice of euthanasia, which ought not be considered a medical act or legitimately compulsory for physicians. Today's medicine counts with effective treatments for pain and suffering, such as palliative care, including sedative therapy, which best preserves persons dignity and keeps safe the ethos of the medical profession.

  11. Legal Careers in the Office of Regional Counsel in Lenexa, KS (EPA Region 7)

    EPA Pesticide Factsheets

    Legal Careers in the Office of Regional Counsel in Lenexa, KS (EPA Region 7). Specific experience with the Resource Conservation and Recovery Act (RCRA), the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA), the Toxic Substances Control Act (TSCA

  12. 7 CFR 1170.2 - Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PRODUCT MANDATORY REPORTING § 1170.2 Act. Act means the Agricultural Marketing Act of 1946, 7 U.S.C. 1621 et seq., as amended by the Dairy Market Enhancement Act...

  13. 76 FR 59073 - Privacy Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-23

    ...: Consistent with the Privacy Act (PA), the Central Intelligence Agency (CIA) has undertaken and completed a... clearly reflect the current CIA organizational structure and policies and practices, and to eliminate... Act (PA), the CIA has undertaken and completed a review of its public PA regulations. As a result...

  14. Implementing the Amended FOI Act.

    ERIC Educational Resources Information Center

    McClain, Wallis

    The Freedom of Information Act amendments, which became effective in February 1975, have so far yielded mixed results. This report provides an account of how different federal agencies are implementing this amended statute. Among the topics discussed are modifications of the original 1966 Freedom of Information Act, which were made in the attempt…

  15. Online Challenge versus Offline ACT

    ERIC Educational Resources Information Center

    Peckham, Irvin

    2010-01-01

    This article compares essays written in response to the ACT Essay prompt and a locally developed prompt used for placement. The two writing situations differ by time and genre: the ACT Essay is timed and argumentative; the locally developed is untimed and explanatory. The article analyzes the differences in student performance and predictive…

  16. Education Leaders Applaud ATTAIN Act

    ERIC Educational Resources Information Center

    Curriculum Review, 2007

    2007-01-01

    This article talks about Achievement Through Technology and Innovation (ATTAIN) Act, a bill introduced by Senators Bingaman (D-NM), Burr (R-NC), and Murray (D-WA) and applauded by a coalition of education and industry groups. The proposed ATTAIN Act is similar to its companion in the House (HR 2449), and builds upon the Enhancing Education Through…

  17. Clean Air Act 1990 Amendments

    SciTech Connect

    Stensvaag, J.M.

    1991-01-01

    This book is an analysis of the 1990 Amendments to the Clean Air Act that includes compliance requirements, the new operating permit system, the enhanced enforcement provisions and criminal penalties, potential for citizen enforcement, and the increased reporting requirements. Also analyzed are the new defenses such as permit compliance and protection of employees acting within the direction of employers.

  18. Biomass Program Recovery Act Factsheet

    SciTech Connect

    2010-03-01

    The Biomass Program has awarded about $718 million in American Recovery and Reinvestment Act (Recovery Act) funds. The projects the Program is supporting are intended to: Accelerate advanced biofuels research, development, and demonstration; Speed the deployment and commercialization of advanced biofuels and bioproducts; Further the U.S. bioindustry through market transformation and creating or saving a range of jobs.

  19. Nurse Reinvestment Act. Public Law.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC.

    This document contains the text of the Nurse Reinvestment Act, which amends the Public Health Service Act to address the increasing shortage of registered nurses by instituting a series of policies to improve nurse recruitment and nurse retention. Title I details two initiatives to boost recruitment of nurses. The first initiative includes the…

  20. 15 CFR 719.2 - Violations of the Act subject to administrative and criminal enforcement proceedings.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ENFORCEMENT § 719.2 Violations of the Act subject to...

  1. 15 CFR 719.2 - Violations of the Act subject to administrative and criminal enforcement proceedings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ENFORCEMENT § 719.2 Violations of the Act subject to...

  2. 76 FR 14439 - No FEAR Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-16

    ... TRANSPARENCY BOARD No FEAR Act Notice AGENCY: Recovery Accountability and Transparency Board. ACTION: Notice... and Retaliation Act (No FEAR Act or Act), as implemented by Office of Personnel Management (OPM... No FEAR Act. See Public Law 107-174, codified at 5 U.S.C. 2301 note. One purpose of the Act is...

  3. 78 FR 7777 - Information Collection Request Submitted to OMB for Review and Approval; Comment Request...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ...; Notification of Chemical Exports--TSCA Section 12(b) AGENCY: Environmental Protection Agency (EPA). ACTION... of Chemical Exports--TSCA Section 12(b)'' and identified as EPA ICR No. 0795.14 and OMB Control No... Section 12(b) ICR numbers: EPA ICR No. 0795.14, OMB Control No. 2070-0030. ICR Status: EPA is...

  4. 76 FR 14655 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-17

    ... approval: Correction of Misreported Chemical Substances on the TSCA Inventory; EPA ICR No. 1741.06, OMB No... review and approval according to the procedures prescribed in 5 CFR 1320.12. On August 6, 2010 (75 FR... Misreported Chemical Substances on the TSCA Inventory; EPA ICR No. 1741.06, OMB No. 2070-0145. ICR...

  5. Chemical Analyses

    NASA Technical Reports Server (NTRS)

    Bulluck, J. W.; Rushing, R. A.

    1994-01-01

    As a preliminary study on the effects of chemical aging of polymer materials MERL and TRI have examined two polymeric materials that are typically used for offshore umbilical applications. These two materials were Tefzel, a copolymer of ethylene and tetrafluoroethylene, and Coflon, polyvinylidene fluoride. The Coflon specimens were cut from pipe sections and exposed to H2S at various temperatures and pressures. One of these specimens was tested for methane permeation, and another for H2S permeation. The Tefzel specimens were cut from .05 mm sheet stock material and were exposed to methanol at elevated temperature and pressure. One of these specimens was exposed to methanol permeation for 2 days at 100 C and 2500 psi. An additional specimen was exposed to liquid methanol for 3 days at 150 C and 15 Bar. Virgin specimens of each material were similarly prepared and tested.

  6. Household Chemical Emergencies

    MedlinePlus

    ... Chemical Emergencies Hurricanes Landslides & Debris Flow Nuclear ... containing hazardous materials or chemicals. Although the risk of a chemical accident is slight, knowing how to handle these products ...

  7. In Silico Studies of the Toxcast Chemicals Interacting with Biomolecular targets

    EPA Science Inventory

    Molecular docking, a structure-based in silico tool for chemical library pre-screening in drug discovery, can be used to explore the potential toxicity of environmental chemicals acting at specific biomelcular targets.

  8. UTILIZING INFORMATION COLLECTED UNDER THE CLEAN WATER ACT FOR PUBLIC HEALTH ANALYSIS

    EPA Science Inventory

    The Clean Water Act was established to "restore and maintain the chemical, physical, and biological integrity of the Nation's waters". Under Section 303(d) of the Clean Water Act, the U.S.Environmental Protection Agency collects information from each state regarding the intended ...

  9. 78 FR 73884 - Notice Pursuant to the National Cooperative Research and Production Act of 1993; National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-09

    ..., Santa Rosa Beach, FL; Defined PRO Machining LLC, Wharton, NJ; Gramago, LLC, Norman, OK; Helicon Chemical... a notice in the Federal Register pursuant to Section 6(b) of the Act on June 30, 2000 (65 FR 40693... Federal Register pursuant to Section 6(b) of the Act on August 26, 2013 (78 FR 52787). Patricia A....

  10. ACTS and OLYMPUS propagation experiments

    NASA Technical Reports Server (NTRS)

    Bostian, Charles W.; Baker, Kenneth R.

    1988-01-01

    The OLYMPUS and ACTS satellites both provide opportunities for 10 to 30 GHz propagation measurements. The spacecraft are sufficiently alike that OLYMPUS can be used to test some prototype ACTS equipment and experiments. Data are particularly needed on short term signal behavior and in support of uplink power control and adaptive forward error correction (FEC) techniques. The Virginia Tech Satellite Communications Group has proposed a set of OLYMPUS experiments including attenuation and fade rate measurements, data communications, uplink power control, rain scatter interference, and small-scale site diversity operation. A digital signal processing receiver for the OLYMPUS and ACTS beacon signals is being developed.

  11. Assessment & Commitment Tracking System (ACTS)

    SciTech Connect

    Bryant, Robert A.; Childs, Teresa A.; Miller, Michael A.; Sellars, Kevin J.

    2004-12-20

    The ACTS computer code provides a centralized tool for planning and scheduling assessments, tracking and managing actions associated with assessments or that result from an event or condition, and "mining" data for reporting and analyzing information for improving performance. The ACTS application is designed to work with the MS SQL database management system. All database interfaces are written in SQL. The following software is used to develop and support the ACTS application: Cold Fusion HTML JavaScript Quest TOAD Microsoft Visual Source Safe (VSS) HTML Mailer for sending email Microsoft SQL Microsoft Internet Information Server

  12. 40 CFR 766.38 - Reporting on precursor chemical substances.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... SUBSTANCES CONTROL ACT DIBENZO-PARA-DIOXINS/DIBENZOFURANS Specific Chemical Testing/Reporting Requirements... molecular structure is conducive to HDD/HDF formation under favorable reaction conditions when they are...

  13. 40 CFR 766.38 - Reporting on precursor chemical substances.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... SUBSTANCES CONTROL ACT DIBENZO-PARA-DIOXINS/DIBENZOFURANS Specific Chemical Testing/Reporting Requirements... molecular structure is conducive to HDD/HDF formation under favorable reaction conditions when they are...

  14. 78 FR 4806 - Proposed Significant New Use Rule on Certain Chemical Substances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-23

    ... protective measures to limit exposures or otherwise mitigate the potential unreasonable risk. The so-called... exposures, thereby constituting a ``significant new use.'' This so-called ``TSCA non- section 5(e) SNUR'' is... incineration of the PMN substances at low temperatures. EPA has preliminary evidence, including data on...

  15. 75 FR 36067 - Agency Information Collection Activities; Proposed Collection; Comment Request; Chemical-Specific...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-24

    ... Rules, TSCA Section 8(a); EPA ICR No. 1198.09, OMB Control No. 2070-0067 AGENCY: Environmental....S.C. 3501 et seq.), this document announces that EPA is planning to submit a request to renew an... and OMB Control No. 2070-0067, is scheduled to expire on January 31, 2011. Before submitting the...

  16. Monitoring EERE's Recovery Act Portfolio

    SciTech Connect

    2011-01-01

    Performance monitoring of Recovery Act projects within EERE has been an ongoing effort. Project recipients have been reporting technical and financial progress to project officers on a quarterly basis.

  17. Summary of the Privacy Act

    EPA Pesticide Factsheets

    The purpose of the Privacy Act is to balance the government's need to maintain information about individuals with the rights of individuals to be protected against unwarranted invasions of their privacy.

  18. Prelinguistic Vocalizations Distinguish Pointing Acts

    ERIC Educational Resources Information Center

    Grunloh, Thomas; Liszkowski, Ulf

    2015-01-01

    The current study investigated whether point-accompanying characteristics, like vocalizations and hand shape, differentiate infants' underlying motives of prelinguistic pointing. We elicited imperative (requestive) and declarative (expressive and informative) pointing acts in experimentally controlled situations, and analyzed accompanying…

  19. Criminal Acts Against Civil Aviation

    DTIC Science & Technology

    1991-01-01

    28 Soviet Union ...34 Feature Articles Civil Aviation in the Soviet Union ................................................................. 39 Attacks on Airline...relief transport aircraft or hijackings; none were related to the Gulf war. Likewise, in Asia, there were few criminal acts against civil aviation

  20. Applying mixture toxicity modelling to predict bacterial bioluminescence inhibition by non-specifically acting pharmaceuticals and specifically acting antibiotics.

    PubMed

    Neale, Peta A; Leusch, Frederic D L; Escher, Beate I

    2017-04-01

    Pharmaceuticals and antibiotics co-occur in the aquatic environment but mixture studies to date have mainly focused on pharmaceuticals alone or antibiotics alone, although differences in mode of action may lead to different effects in mixtures. In this study we used the Bacterial Luminescence Toxicity Screen (BLT-Screen) after acute (0.5 h) and chronic (16 h) exposure to evaluate how non-specifically acting pharmaceuticals and specifically acting antibiotics act together in mixtures. Three models were applied to predict mixture toxicity including concentration addition, independent action and the two-step prediction (TSP) model, which groups similarly acting chemicals together using concentration addition, followed by independent action to combine the two groups. All non-antibiotic pharmaceuticals had similar EC50 values at both 0.5 and 16 h, indicating together with a QSAR (Quantitative Structure-Activity Relationship) analysis that they act as baseline toxicants. In contrast, the antibiotics' EC50 values decreased by up to three orders of magnitude after 16 h, which can be explained by their specific effect on bacteria. Equipotent mixtures of non-antibiotic pharmaceuticals only, antibiotics only and both non-antibiotic pharmaceuticals and antibiotics were prepared based on the single chemical results. The mixture toxicity models were all in close agreement with the experimental results, with predicted EC50 values within a factor of two of the experimental results. This suggests that concentration addition can be applied to bacterial assays to model the mixture effects of environmental samples containing both specifically and non-specifically acting chemicals.

  1. Clean Air Act: Senate mulls revision bill

    SciTech Connect

    Fairley, P.

    1995-12-13

    Senator Lauch Faircloth (R., NC) has circulated a draft summary of possible revisions of the Clean Air Act (CAA). Chemical industry sources say the proposal would provide some regulatory relief but fear that supporting Faircloth could jeopardize their relationship with EPA. Faircloth`s proposal addresses various controversial aspect of CAA`s Title V permit program including the monitoring and permit modification provisions. The proposal would also define a facility`s {open_quotes}potential to emit,{close_quotes} upon which Title V permits are based. In the past year EPA has substantially revised its Title V program to address complaints from industry, the states, and Congress that the monitoring and modification provisions were too burdensome.

  2. 77 FR 75145 - Impact of the Implementation of the Chemical Weapons Convention (CWC) on Commercial Activities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... Bureau of Industry and Security Impact of the Implementation of the Chemical Weapons Convention (CWC) on... implementation of the Chemical Weapons Convention (CWC), through the Chemical Weapons Convention Implementation Act (CWCIA) and the Chemical Weapons Convention Regulations (CWCR), has had on commercial...

  3. 75 FR 24688 - Access to Confidential Business Information by Guident Technologies Inc.’s Identified Subcontractor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-05

    ... has been submitted to EPA under all sections of the Toxic Substances Control Act (TSCA). Some of the...., Washington, DC 20460- 0001; telephone number: (202) 554-1404; e-mail address: TSCA-Hotline@epa.gov . For..., DC 20460-0001; telephone number: (202) 564-8257; fax number: (202) 564-8251; e-mail address:...

  4. 40 CFR 761.253 - Chemical analysis.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Chemical analysis. 761.253 Section 761.253 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT... for Evaluating Solid Waste, or a method validated under subpart Q of this part. Use Method 8082...

  5. 40 CFR 761.253 - Chemical analysis.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Chemical analysis. 761.253 Section 761.253 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT... Sample Sites, Collecting Surface Samples, and Analyzing Standard PCB Wipe Samples § 761.253...

  6. 40 CFR 761.253 - Chemical analysis.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Chemical analysis. 761.253 Section 761.253 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT... Sample Sites, Collecting Surface Samples, and Analyzing Standard PCB Wipe Samples § 761.253...

  7. 40 CFR 761.253 - Chemical analysis.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Chemical analysis. 761.253 Section 761.253 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT... Sample Sites, Collecting Surface Samples, and Analyzing Standard PCB Wipe Samples § 761.253...

  8. 40 CFR 761.253 - Chemical analysis.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Chemical analysis. 761.253 Section 761.253 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT... Sample Sites, Collecting Surface Samples, and Analyzing Standard PCB Wipe Samples § 761.253...

  9. Chemical Facility Preparedness: A Comprehensive Approach

    DTIC Science & Technology

    2006-09-01

    Situation ...............................................................................20 6. Lessons Learned from Disasters...Because of this situation , a catastrophic chemical release or explosion at these facilities could kill thousands or tens of thousands of Americans...facilities remain inadequately prepared for acts of terrorism. Two primary reasons influence this situation . First, few requirements exist regarding

  10. 77 FR 60962 - Clean Water Act; Contractor Access to Confidential Business Information

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-05

    ... EPA and in EPA's confidentiality regulations found at 40 CFR part 2, Subpart B. ERG will adhere to EPA... and dressing; organic chemicals, plastics, and synthetic fibers; pesticide chemicals; petroleum..., 2012. Jeffrey L. Lape, Acting Director, Office of Science and Technology. BILLING CODE 6560-50-P...

  11. USA PATRIOT Improvement and Reauthorization Act of 2005: A Legal Analysis

    DTIC Science & Technology

    2006-12-21

    Act contains subtitles concerning regulation of domestic and international commerce in three methamphetamine (meth) precursor chemicals: ephedrine ...197 The bill defines a “scheduled listed chemicals product” as one “that contains ephedrine , (continued...) The degree of regulatory scrutiny...over-the-counter sale, without regulatory complications, of cold remedies containing ephedrine , pseudoephedrine or phenlypropanolamine (EPP

  12. 7 CFR 33.1 - Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AUTHORITY OF THE EXPORT APPLE ACT Definitions § 33.1 Act. Act and Export Apple Act are synonymous and mean “An act to promote the foreign trade of the United States in apples to protect the reputation of American-grown apples in foreign markets, to prevent deception or misrepresentation as to the quality...

  13. 7 CFR 33.1 - Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AUTHORITY OF THE EXPORT APPLE ACT Definitions § 33.1 Act. Act and Export Apple Act are synonymous and mean “An act to promote the foreign trade of the United States in apples to protect the reputation of American-grown apples in foreign markets, to prevent deception or misrepresentation as to the quality...

  14. 7 CFR 33.1 - Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AUTHORITY OF THE EXPORT APPLE ACT Definitions § 33.1 Act. Act and Export Apple Act are synonymous and mean “An act to promote the foreign trade of the United States in apples to protect the reputation of American-grown apples in foreign markets, to prevent deception or misrepresentation as to the quality...

  15. 7 CFR 33.1 - Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AUTHORITY OF THE EXPORT APPLE ACT Definitions § 33.1 Act. Act and Export Apple Act are synonymous and mean “An act to promote the foreign trade of the United States in apples to protect the reputation of American-grown apples in foreign markets, to prevent deception or misrepresentation as to the quality...

  16. 7 CFR 33.1 - Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AUTHORITY OF THE EXPORT APPLE ACT Definitions § 33.1 Act. Act and Export Apple Act are synonymous and mean “An act to promote the foreign trade of the United States in apples to protect the reputation of American-grown apples in foreign markets, to prevent deception or misrepresentation as to the quality...

  17. 78 FR 17403 - No FEAR Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-21

    ... AGENCY No FEAR Act Notice AGENCY: Federal Housing Finance Agency. ACTION: Notice. SUMMARY: The Federal... and Federal Employee Antidiscrimination and Retaliation Act of 2002, which is now known as the No FEAR Act (No FEAR Act), (Pub. L. 107-174). One purpose of the No FEAR Act is to require that...

  18. 7 CFR 1170.2 - Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PRODUCT MANDATORY REPORTING § 1170.2 Act. Act means the Agricultural Marketing Act of 1946, 7 U.S.C. 1621 et seq., as amended by the Dairy Market Enhancement Act of 2000, Public Law 106-532, 114 Stat. 2541, and the Farm Security and Rural Investment Act of...

  19. 7 CFR 1170.2 - Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ORDERS; MILK), DEPARTMENT OF AGRICULTURE DAIRY PRODUCT MANDATORY REPORTING § 1170.2 Act. Act means the Agricultural Marketing Act of 1946, 7 U.S.C. 1621 et seq., as amended by the Dairy Market Enhancement Act of 2000, Pub. L. 106-532, 114 Stat. 2541; the Farm Security and Rural Investment Act of 2002, Pub. L....

  20. 7 CFR 1170.2 - Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ORDERS; MILK), DEPARTMENT OF AGRICULTURE DAIRY PRODUCT MANDATORY REPORTING § 1170.2 Act. Act means the Agricultural Marketing Act of 1946, 7 U.S.C. 1621 et seq., as amended by the Dairy Market Enhancement Act of 2000, Pub. L. 106-532, 114 Stat. 2541; the Farm Security and Rural Investment Act of 2002, Pub. L....

  1. 7 CFR 1170.2 - Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PRODUCT MANDATORY REPORTING § 1170.2 Act. Act means the Agricultural Marketing Act of 1946, 7 U.S.C. 1621 et seq., as amended by the Dairy Market Enhancement Act of 2000, Public Law 106-532, 114 Stat. 2541, and the Farm Security and Rural Investment Act of...

  2. Standard Review Risk Assessment on Medium-chain and Long-chain Chlorinated paraffin PMN submissions by Qualice, LLC

    EPA Pesticide Factsheets

    This assessment was conducted under EPA’s TSCA Section 5 New Chemicals Program. EPA is assessing Medium-chain Chlorinated Paraffin (MCCP) and Long-Chain Chlorinated Paraffin (LCCP) chemicals as part of its New Chemicals Review program.

  3. Standard Review Risk Assessment on Medium-chain and Long-chain Chlorinated paraffin PMN submissions by INEOS Chlor Americas

    EPA Pesticide Factsheets

    This assessment was conducted under EPA’s TSCA Section 5 New Chemicals Program. EPA is assessing Medium-chain Chlorinated Paraffin (MCCP) and Long-Chain Chlorinated Paraffin (LCCP) chemicals as part of its New Chemicals Review program.

  4. Chemical Genetics in Dissecting Membrane Glycerolipid Functions.

    PubMed

    Chevalier, Florian; Carrera, Laura Cuyàs; Nussaume, Laurent; Maréchal, Eric

    2016-01-01

    Chemical genetics has emerged as a powerful approach to dissect biological processes, based on the utilization of small molecules disturbing the function of specific target proteins. By analogy with classical genetics, 'reverse chemical genetics' refers to the utilization of drugs acting on a known target, enabling its functional characterization at the levels of the cells, tissues and organisms. Likewise, 'direct chemical genetics' refers to the utilization of a drug of unknown mode of action, but triggering a phenotype of interest. In that case, one has to identify the target(s) possibly blocked (or possibly activated) by the small molecule. This chapter illustrates both approaches, like the analysis of the elongation of fatty acids, the biosynthesis of galactoglycerolipids or the catabolism of phosphoglycerolipids by reverse chemical genetics or the study of the membrane glycerolipid remodeling triggered upon phosphate starvation, by direct chemical genetics.

  5. Ultrafast Dynamics of Chemical Reactions.

    DTIC Science & Technology

    2007-11-02

    Michael R. Berman 11 SUPPLEMENTARY NOTES 12a D!STRIBUTION AVAILABILITY STATEMENT 12b. DISTRIBUTION CODE 13 Ap’-,T,,,ACT `’,Ii "•--200words) The research and...Caltech), Professor K. Wilson (UC, San Diego), and Professor J. Polanyi (Toronto). 3 6. Publications (1995/1996) Books Collected Works (up to 1994...1995) Direct Observation of The Transition State J. C. Polanyi and A. H. Zewail Accounts of Chemical Research (Holy-Grail Special Issue), 28,119 (1995

  6. 7 CFR 65.100 - Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL..., AND GINSENG General Provisions Definitions § 65.100 Act. Act means the Agricultural Marketing Act...

  7. 7 CFR 1150.101 - Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Dairy Promotion and Research Order Definitions § 1150.101 Act. Act means Title I, Subtitle B, of the Dairy and Tobacco Adjustment Act of...

  8. An Example of a Human Topological Rubber Glove Act

    NASA Astrophysics Data System (ADS)

    Chai Toong, Yock; Yung Wang, Shih

    1997-04-01

    A hitherto unreported human body narcissistic inversion which is an example of the rubber glove act has been uncovered from a Chinese acrobatic performance. This inversion is related to the unimolecular enantiomerizations of chiral molecules, a topological figure and a rubber glove via chiral pathway. The possible mechanism of enantiomerization of an unknown cyclopolypetide based on this finding is suggested. The importance of chemical topology in biomolecules is stressed.

  9. The chemical and environmental property space of REACH chemicals.

    PubMed

    Öberg, Tomas; Iqbal, M Sarfraz

    2012-05-01

    The European regulation on chemicals, REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals), came into force on 1 June 2007. With pre-registration complete in 2008, data for these substances may provide an overview of the expected chemical space and its characteristics. In this paper, using various in silico computation tools, we evaluate 48782 neutral organic compounds from the list to identify hazardous and safe compounds. Two different classification schemes (modified Verhaar and ECOSAR) identified between 17% and 25% of the compounds as expressing only baseline toxicity (narcosis). A smaller portion could be identified as reactive (19%) or specifically acting (2.7%), while the majority were non-assigned (61%). Overall environmental persistence, bioaccumulation and long-range transport potential were evaluated using structure-activity relationships and a multimedia fugacity-based model. A surprisingly high proportion of compounds (20%), mainly aromatic and halogenated, had a very high estimated persistence (>195 d). The proportion of compounds with a very high estimated bioconcentration or bioaccumulation factor (>5000) was substantially less (6.9%). Finally, a list was compiled of those compounds within the applicability domain of the models used, meeting both persistence and bioaccumulation criteria, and with a long-range transport potential comparable to PCB. This list of 68 potential persistent organic pollutants contained many well-known compounds (all halogenated), but notably also five fluorinated compounds that were not included in the EINECS inventory. This study demonstrates the usability of in silico tools for identification of potentially environmentally hazardous chemicals.

  10. CHEMICAL SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORS

    PubMed Central

    Swarts, Benjamin M.; Guo, Zhongwu

    2013-01-01

    Many eukaryotic cell-surface proteins and glycoproteins are anchored to the plasma membrane by glycosylphosphatidylinositols (GPIs), a family of glycolipids that are post-translationally attached to proteins at their C-termini. GPIs and GPI-anchored proteins play important roles in many biological and pathological events, such as cell recognition and adhesion, signal transduction, host defense, and acting as receptors for viruses and toxins. Chemical synthesis of structurally defined GPI anchors and GPI derivatives is a necessary step toward understanding the properties and functions of these molecules in biological systems and exploring their potential therapeutic applications. In the first part of this comprehensive article on the chemical synthesis of GPIs, classic syntheses of naturally occurring GPI anchors from protozoan parasites, yeast, and mammals are covered. The second part of the article focuses on recent diversity-oriented strategies for the synthesis of GPI anchors containing unsaturated lipids, “click chemistry” tags, and highly branched and modified structures. PMID:22794184

  11. Chemical Ecology: Chemical Communication in Nature.

    ERIC Educational Resources Information Center

    Wood, William F.

    1983-01-01

    Substances that deliver chemical messages between same/different species are called semiochemicals. Surveyed are three types of semiochemicals (pheromones, allomones, and kairomones), types of organisms involved, and specific chemicals used to carry the various kinds of messages. (JN)

  12. Self-acting shaft seals

    NASA Technical Reports Server (NTRS)

    Ludwig, L. P.

    1978-01-01

    Self-acting seals are described in detail. The mathematical models for obtaining a seal force balance and the equilibrium operating film thickness are outlined. Particular attention is given to primary ring response (seal vibration) to rotating seat face runout. This response analysis reveals three different vibration models with secondary seal friction being an important parameter. Leakage flow inlet pressure drop and affects of axisymmetric sealing face deformations are discussed. Experimental data on self-acting face seals operating under simulated gas turbine conditions are given. Also a spiral groove seal design operated to 244 m/sec (800 ft/sec) is described.

  13. Long-acting reversible contraception.

    PubMed

    Peck, Susan A

    2013-10-01

    Although short-acting reversible hormonal contraceptives, such as oral contraceptives and the contraceptive patch and vaginal ring, remain the most commonly used contraceptive methods in the United States, they are also associated with the highest failure rates. Long-acting reversible contraception (LARC) methods, such as intrauterine devices and contraceptive implants, offer high continuation rates and very low failure rates, and are safe for use in most women. The provision of LARC methods to adolescent, young adult and nulliparous women is a relatively new concept that offers an innovative option for these populations.

  14. Advanced Communications Technology Satellite (ACTS)

    NASA Technical Reports Server (NTRS)

    Gedney, Richard T.; Schertler, Ronald J.

    1989-01-01

    The NASA Advanced Communications Technology Satellite (ACTS) was conceived to help maintain U.S. leadership in the world's communications-satellite market. This experimental satellite is expected to be launched by NASA in 1992 and to furnish the technology necessary for establishing very small aperture terminal digital networks which provide on-demand full-mesh connectivity, and 1.544-MBPS services with only a single hop. Utilizing on-board switching and processing, each individual voice or data circuit can be separately routed to any location in the network. This paper provides an overview of the ACTS and discusses the value of the technology for future communications systems.

  15. 7 CFR 1207.302 - Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan Definitions § 1207.302 Act. Act means the Potato Research...

  16. 7 CFR 1207.302 - Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan Definitions § 1207.302 Act. Act means the Potato Research...

  17. 7 CFR 1207.302 - Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan Definitions § 1207.302 Act. Act means the Potato Research...

  18. 7 CFR 1207.302 - Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan Definitions § 1207.302 Act. Act means the Potato Research...

  19. 7 CFR 1207.302 - Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan Definitions § 1207.302 Act. Act means the Potato Research...

  20. 7 CFR 1221.1 - Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SORGHUM PROMOTION, RESEARCH, AND INFORMATION ORDER Sorghum Promotion, Research, and Information Order Definitions § 1221.1 Act. Act means...

  1. 7 CFR 1221.1 - Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SORGHUM PROMOTION, RESEARCH, AND INFORMATION ORDER Sorghum Promotion, Research, and Information Order Definitions § 1221.1 Act. Act means...

  2. 7 CFR 1221.1 - Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SORGHUM PROMOTION, RESEARCH, AND INFORMATION ORDER Sorghum Promotion, Research, and Information Order Definitions § 1221.1 Act. Act means...

  3. 7 CFR 1221.1 - Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SORGHUM PROMOTION, RESEARCH, AND INFORMATION ORDER Sorghum Promotion, Research, and Information Order Definitions § 1221.1 Act. Act means...

  4. 7 CFR 1221.1 - Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SORGHUM PROMOTION, RESEARCH, AND INFORMATION ORDER Sorghum Promotion, Research, and Information Order Definitions § 1221.1 Act. Act means...

  5. 7 CFR 1218.1 - Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BLUEBERRY PROMOTION, RESEARCH, AND INFORMATION ORDER Blueberry Promotion, Research, and Information Order Definitions § 1218.1 Act. Act means...

  6. 7 CFR 1218.1 - Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BLUEBERRY PROMOTION, RESEARCH, AND INFORMATION ORDER Blueberry Promotion, Research, and Information Order Definitions § 1218.1 Act. Act means...

  7. 7 CFR 1218.1 - Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BLUEBERRY PROMOTION, RESEARCH, AND INFORMATION ORDER Blueberry Promotion, Research, and Information Order Definitions § 1218.1 Act. Act means...

  8. 7 CFR 1218.1 - Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BLUEBERRY PROMOTION, RESEARCH, AND INFORMATION ORDER Blueberry Promotion, Research, and Information Order Definitions § 1218.1 Act. Act means...

  9. 7 CFR 1218.1 - Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BLUEBERRY PROMOTION, RESEARCH, AND INFORMATION ORDER Blueberry Promotion, Research, and Information Order Definitions § 1218.1 Act. Act means...

  10. 7 CFR 65.100 - Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) COUNTRY OF ORIGIN LABELING OF BEEF, PORK, LAMB, CHICKEN, GOAT MEAT, PERISHABLE AGRICULTURAL COMMODITIES, MACADAMIA NUTS, PECANS,...

  11. 7 CFR 65.100 - Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) COUNTRY OF ORIGIN LABELING OF BEEF, PORK, LAMB, CHICKEN, GOAT MEAT, PERISHABLE AGRICULTURAL COMMODITIES, MACADAMIA NUTS, PECANS,...

  12. 7 CFR 65.100 - Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) COUNTRY OF ORIGIN LABELING OF BEEF, PORK, LAMB, CHICKEN, GOAT MEAT, PERISHABLE AGRICULTURAL COMMODITIES, MACADAMIA NUTS, PECANS,...

  13. 7 CFR 65.100 - Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) COUNTRY OF ORIGIN LABELING OF BEEF, PORK, LAMB, CHICKEN, GOAT MEAT, PERISHABLE AGRICULTURAL COMMODITIES, MACADAMIA NUTS, PECANS,...

  14. 7 CFR 1216.1 - Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE PEANUT PROMOTION, RESEARCH, AND INFORMATION ORDER Peanut Promotion, Research, and Information Order Definitions § 1216.1 Act. Act means...

  15. 7 CFR 1216.1 - Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE PEANUT PROMOTION, RESEARCH, AND INFORMATION ORDER Peanut Promotion, Research, and Information Order Definitions § 1216.1 Act. Act means...

  16. 7 CFR 1216.1 - Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE PEANUT PROMOTION, RESEARCH, AND INFORMATION ORDER Peanut Promotion, Research, and Information Order Definitions § 1216.1 Act. Act means...

  17. 7 CFR 1216.1 - Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE PEANUT PROMOTION, RESEARCH, AND INFORMATION ORDER Peanut Promotion, Research, and Information Order Definitions § 1216.1 Act. Act means...

  18. 7 CFR 1216.1 - Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE PEANUT PROMOTION, RESEARCH, AND INFORMATION ORDER Peanut Promotion, Research, and Information Order Definitions § 1216.1 Act. Act means...

  19. 7 CFR 1220.600 - Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Procedures To Request a Referendum Definitions § 1220.600 Act. Act means the...

  20. 7 CFR 1220.600 - Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Procedures To Request a Referendum Definitions § 1220.600 Act. Act means the...