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Sample records for acta informatica medica

  1. Acta informatica medica is indexed in pubmed and archived in pubmed central.

    PubMed

    Masic, Izet

    2013-03-01

    Acta Informatica Medica journal has been accepted for archiving in PubMed Central from 2011 onward. The journal started in 1993 as the official journal of the Society for Medical Informatics of Bosnia and Herzegovina. During the last 3 years, Acta Informatica Medica has een included in almost all prestigious online databases, including PubMed, Scopus and EMBASE. The 20th volume of the journal is fully international, with papers from 18 countries.

  2. Review of the Journal Acta Informatica Medica During Eight Year Period: 2008-2015

    PubMed Central

    Masic, Izet; Begic, Edin; Zunic, Lejla

    2016-01-01

    Introduction: Acta Informatica Medica is official journal of the Academy for Medical Sciences of Bosnia and Herzegovina (from 2014 Acta Inform Med is published bimonthly). Aim: To evaluate journal “Acta Informatica Medica” in 2015 and compare findings to previous years. Material and methods: The study has retrospective and descriptive character, and included the period 2008-2015 (included 36 issues of journal). Results: A total of 83 (average 13,8 articles per journal) articles were published in Acta Informatica Medica during 2015. Analyzing the type of articles, original articles are present in majority during 2015 (68,6%) (by analyzing last eight years, 310 (67,3%) were original). During 2015, 27,7% of articles were related to the applied of Health informatics in field of clinical medicine, 63,8% preclinical medicine and 8,5% to public health. Collaboration rate in 2015 was 0,84. Most often the time required for decision on acceptance of article in 2015 is between 50 and 60 days. Articles came from 16 countries. According to scimagojr.com for 2014, Acta Informatica Medica has SCImago Journal Rank 0,166, while Cites / Doc. (2 years) parameter (widely used as impact index) is 0,70. According to GoogleScholar, h5 index is 11 and h5 median is 19. We analyzed the Acta Informatica Medica by “Publish or Perish” software - H index was 14, g index was 19 and e-index was 10.39. Conclusion: Year after year the highest number of original articles are published. Although the period of revision of articles is acceptable, the period up to two months is certainly not long, the goal is to reduce this period. Although the magazine in mentioned field found its place, although it is indexed in numerous bases, including: PubMed, PubMed Central, SCOPUS, EMBASE, EBSCO, etc. The main goal for next year is that the magazine becomes part of the Web of Science. Imperative is further internationalization of the magazine. PMID:27147796

  3. Twenty years of society of medical informatics of b&h and the journal acta informatica medica.

    PubMed

    Masic, Izet

    2012-03-01

    In 2012, Health/Medical informatics profession celebrates five jubilees in Bosnia and Herzegovina: a) Thirty five years from the introduction of the first automatic manipulation of data; b) Twenty five years from establishing Society for Medical Informatics BiH; c) Twenty years from establishing scientific and professional journal of the Society for Medical Informatics of Bosnia and Herzegovina "Acta Informatica Medica"; d) Twenty years from establishing first Cathdra for Medical Informatics on biomedical faculties in Bosnia and Herzegovina and e) Ten years from the introduction of "Distance learning" in medical curriculum. All of the five mentioned activities in the area of Medical informatics had special importance and gave appropriate contribution in the development of Health/Medical informatics in Bosnia And Herzegovina.

  4. Twenty Years of Society of Medical Informatics of B&H and the Journal Acta Informatica Medica

    PubMed Central

    Masic, Izet

    2012-01-01

    In 2012, Health/Medical informatics profession celebrates five jubilees in Bosnia and Herzegovina: a) Thirty five years from the introduction of the first automatic manipulation of data; b) Twenty five years from establishing Society for Medical Informatics BiH; c) Twenty years from establishing scientific and professional journal of the Society for Medical Informatics of Bosnia and Herzegovina „Acta Informatica Medica“; d) Twenty years from establishing first Cathdra for Medical Informatics on biomedical faculties in Bosnia and Herzegovina and e) Ten years from the introduction of “Distance learning” in medical curriculum. All of the five mentioned activities in the area of Medical informatics had special importance and gave appropriate contribution in the development of Health/Medical informatics in Bosnia And Herzegovina. PMID:23322947

  5. Acta Genetica Sinica (Selected Articles),

    DTIC Science & Technology

    1986-04-04

    0879-8SF/ /3 N IT 0󈧬 112. MIRCK L~~Nj~ %. *- - - - - - - - -I.. * .. - II , I FTD-ID(RS)T-0879-85 oM FOREIGN TECHNOLOGY DIVISION ACTA GENETICA SINICA...34 ’ ° ° ° !4 :A.. it.i FTD- ID(RS)T-0879-85 HUMAN TRANSLATION FTD-ID(RS)T-0879-85 4 April 1986 MICROFICHE NR: FTD-86-C-001691 ACTA GENETICA SINICA...merged into this translation were extracted from the best quality copy available. •i 12 (2): 93-101, 1985 Yichuan Xuebao (Acta Genetica Sinica) Genetic

  6. Scientometric Analysis of the Journals of the Academy of Medical Sciences in Bosnia and Herzegovina

    PubMed Central

    Masic, Izet; Begic, Edin; Zunic, Lejla

    2016-01-01

    Introduction: Currently in Bosnia and Herzegovina there are 25 journals in the field of biomedicine, 6 of them are indexed in Medline/PubMed base (Medical Archives, Materia Socio-Medica, Acta Informatica Medica, Acta Medica Academica, Bosnian Journal of Basic Medical Sciences (BJBMS) and Medical Glasnik), and one (BJBMS) is indexed in Science Citation Index Expanded (SCIE)/Web of Science base. Aim: The aim of this study was to show the scope of work of the journals that were published by Academy of Medical Sciences of Bosnia and Herzegovina - Medical Archives, Materia Socio-Medica and Acta Informatica Medica. Material and Methods: The research presents a meta-analysis of three journals, or their issues, during the calendar year 2015 (retrospective and descriptive character). Results: During 2015 calendar year a total of 286 articles were published (in Medical Archives 104 (36.3%), in Materia Socio-Medica 99 (34.6%), and in Acta Informatica Medica 83 (29%)). Original articles are present in the highest number in all three journals (in Medical Archives 80.7%, in Materia Socio Medica 77.7%, and in Acta Informatica Medica 68.6%). In Medical Archives, 90.3% of the articles were related to the field of clinical medicine. In Materia Socio-Medica, the domain of clinical medicine and public health was the most represented. Preclinical areas are most frequent in Acta Informatica Medica. The period of 50-60 days for a decision on the admission of article is most common in all three journals, with trend of shortening of that period. Articles came from 19 countries, mostly from Bosnia and Herzegovina, then from Iran, Kosovo, Saudi Arabia and Greece. Conclusion: In Medical Archives original articles in the field of clinical medicine (usually internal and surgical disciplines) are most often present, and that is the case in last four years. The number of articles in Materia Socio-Medica and Acta Informatica Medica is growing from year to year. In Materia Socio-Medica there is a

  7. [Materia medica in apothecary shops].

    PubMed

    Hadzović, S; Masić, I

    1999-01-01

    Even in 15th and 16th century there were people in Bosnia, preparing medicaments and selling different kinds of medical herbs. At first, they were Jews, later Muslims. They were called "attars"--drugsellers. They were very familiar with herbs of medical purpose. They could recognize herb by its colour and outlook. The goods were sold in specialized shops--attar shop. When analysing Materia Medica from an attar shop--according to the list from the 1911 (dr. Moritz Levy: "Sefards in Bosnia"), we can conclude that assortment of medical herbs and some medicaments was correct. Some Galen forms used in that time, are still in use nowadays. This paper describes all materials encompassed by Materia Medica. They are classified as organic and non-organic materials, and their use in therapy was also emphasized. Materia Medica of attar shops gives us a lot of material for research of non-official medicine and pharmacy from that time.

  8. Natural medicaments in dentistry

    PubMed Central

    Sinha, Dakshita J.; Sinha, Ashish A.

    2014-01-01

    The major objective in root canal treatment is to disinfect the entire root canal system. Cleaning, shaping, and use of antimicrobial medicaments are effective in reducing the bacterial load to some extent, but some bacteria do remain behind and multiply, causing reinfection. Taking into consideration the ineffectiveness, potential side-effects and safety concerns of synthetic drugs, the herbal alternatives for endodontic usage might prove to be advantageous. Over the past decade, interest in drugs derived from medicinal plants has markedly increased. Phytomedicine has been used in dentistry as anti-inflammatory, antibiotic, analgesic, sedative and also as endodontic irrigant. Herbal preparations can be derived from the root, leaves, seeds, stem, and flowers. The PubMed database search revealed that the reference list for natural medicaments featured 1480 articles and in dentistry 173 articles. A forward search was undertaken on the selected articles and author names. This review focuses on various natural drugs and products as well as their therapeutic applications when used as phytomedicine in dentistry. PMID:25558153

  9. Natural medicaments in dentistry.

    PubMed

    Sinha, Dakshita J; Sinha, Ashish A

    2014-04-01

    The major objective in root canal treatment is to disinfect the entire root canal system. Cleaning, shaping, and use of antimicrobial medicaments are effective in reducing the bacterial load to some extent, but some bacteria do remain behind and multiply, causing reinfection. Taking into consideration the ineffectiveness, potential side-effects and safety concerns of synthetic drugs, the herbal alternatives for endodontic usage might prove to be advantageous. Over the past decade, interest in drugs derived from medicinal plants has markedly increased. Phytomedicine has been used in dentistry as anti-inflammatory, antibiotic, analgesic, sedative and also as endodontic irrigant. Herbal preparations can be derived from the root, leaves, seeds, stem, and flowers. The PubMed database search revealed that the reference list for natural medicaments featured 1480 articles and in dentistry 173 articles. A forward search was undertaken on the selected articles and author names. This review focuses on various natural drugs and products as well as their therapeutic applications when used as phytomedicine in dentistry.

  10. ACTA Technology Presents EPA with Patent Copy

    EPA Pesticide Factsheets

    US EPA SBIR awardee, ACTA Technology, presented James H. Johnson, Director of the US EPA National Center for Environmental Research, and April Richards, Program Manager of the US EPA's SBIR Program, with a copy of their Red Ribbon patent.

  11. [Melatonina: old molecule, new medicament].

    PubMed

    Fernández-Tresguerres Hernández, Jesús A

    2008-01-01

    Melatonin is a hormone with indolaminic structure, produced in the pineal gland during darkness, with chronobiological activity that has been known for decades. It is a physiological inducer of sleep and for this indication has been developed as a drug since many years in many international pharmaceutical markets. It has also a relevant antinflammatory and antioxydant capacity that results in beneficial actions on the liver, on cardiovascular diseases, inflammatory processes, in osteoporosis and also in certain tumours. Its neuroprotective action gives founded expectancies of having potential positive effects in several neurodegenerative diseases like parkinson or Alzheimer. It has been recently approved as a drug in the European Medicament Agency (EMEA) and the Spanish Medicament Agency as well. Some of its more relevant pharmacological actions are reviewed.

  12. [The thirty years of Acta Genetica Sinica].

    PubMed

    Li, Shao-Wu; Zhou, Su; Xue, Yong-Biao; Zhu, Li-Huang

    2003-04-01

    Acta Genetica Sinica (AGS) is sponsored by the Genetics Society of China and the Institute of Genetics and Developmental Biology of Chinese Academy of Sciences, and is published by Science Press. The journal is a leading national academic periodical and one of the Chinese key periodicals of natural sciences. Currently, AGS is being indexed by several well-known domestic and international indexing systems, such as the American Chemical Digest (CA), BIOSIS database, Biological Digest (BA), Medical Index and Russian Digest (P [symbol: see text]). Papers in the areas of genetics, developmental biology, cell molecular biology and evolution are regularly published by AGS.

  13. 50th Anniversary of Acta stomatologica Croatica

    PubMed Central

    2016-01-01

    Summary Acta stomatologica Croatisa (ASCRO) is scientific-professional magazine whose first issue was published back in 1966. Ever since the magazine publishers were the School of Dental Medicine of the University of Zagreb and the Croatian Dental Association of the Croatian Medical Association. Over the past fifty years two hundred regular editions were pubslihed along with three additions. The magazine has been internationally indexed and it was granted the DOI number. In this way by means of CrossCheck possible plagiarisms are being checked which aims at obtaining originality of the published results. Another peculiarity of ASCRO is bilingualism throughout the whole edition, international recognizability, open source and tradition based on sound foundations. PMID:27688420

  14. [Irrigants and intracanal medicaments in endodontics].

    PubMed

    Zehnder, Matthias; Lehnert, Birgit; Schönenberger, Kathrin; Waltimo, Tuomas

    2003-01-01

    Modern, biologic root canal therapy should be performed with suitable irrigating solutions and intracanal medicaments. The goal of endodontic treatment is to free the treated tooth from infection and prevent reinfection as thoroughly as possible by means which do not put the organism at risk. In this review of the literature, an evidence-based concept for irrigation and medication of root canal systems is presented. Irrigants and medicaments are discussed with respect to their antimicrobial, tissue-dissolving and endotoxin-decontaminating capacity in relation to their systemic toxicity. Recent findings pertaining to interactions of root canal medicaments and irrigating solutions and their impact on a sound irrigating and medicating concept are discussed.

  15. [A accurate identification method for Chinese materia medica--systematic identification of Chinese materia medica].

    PubMed

    Wang, Xue-Yong; Liao, Cai-Li; Liu, Si-Qi; Liu, Chun-Sheng; Shao, Ai-Juan; Huang, Lu-Qi

    2013-05-01

    This paper put forward a more accurate identification method for identification of Chinese materia medica (CMM), the systematic identification of Chinese materia medica (SICMM) , which might solve difficulties in CMM identification used the ordinary traditional ways. Concepts, mechanisms and methods of SICMM were systematically introduced and possibility was proved by experiments. The establishment of SICMM will solve problems in identification of Chinese materia medica not only in phenotypic characters like the mnorphous, microstructure, chemical constituents, but also further discovery evolution and classification of species, subspecies and population in medical plants. The establishment of SICMM will improve the development of identification of CMM and create a more extensive study space.

  16. Entering the 60th year of Acta Astronautica

    NASA Astrophysics Data System (ADS)

    Chang, Yi-Wei; Chern, Jeng-Shing; Marec, Jean-Pierre

    2014-04-01

    The Acta Astronautica Journal was firstly published in 1955 as the official Journal of the International Astronautical Federation (IAF) with the title Astronautica Acta. It is entering its 60th year in 2014. In 1962, the Astronautica Acta became the official Journal of the International Academy of Astronautics (IAA) established in 1960. A total of 18 volumes had been published from 1955 to 1973 under the leadership of three Editor-in-Chiefs: F. Hecht, Theodore von Karman, and Martin Summerfield. In 1974, A.K. Oppenheim became the new Editor-in-Chief and several evolved changes were performed including change of the title to Acta Astronautica (for grammatical correctness), cover page change, and format change. From 1974 to 2010, another three Editor-in-Chiefs led the journal with 67 volumes published. They were A.K. Oppenheim, Jean-Pierre Marec, and Rupert Gerzer. The current Editor-in-Chief Jeng-Shing Chern (Rock) took over the job from 2011. Total pages and articles published in 2012 are 3586 and 356, respectively. Currently, the Acta Astronautica Editorial Board consists of one Editor-in-Chief, 15 Co-Editors, one Managing Editor and one Honorary Editor-in-Chief (Jean-Pierre Marec). After 59 years, the Acta Astronautica has become a well-known journal worldwide. Its current rank and impact factor are 7/63 and 0.701, respectively. This paper presents some of the details as well as new strategies and steps. In particular, supports from the IAA Academicians are mandatory and most welcome.

  17. Elsevier/Spectrochimica Acta Atomic Spectroscopy Award 2014

    NASA Astrophysics Data System (ADS)

    Omenetto, Nicolo'; de Loos, Greet

    2016-03-01

    This is to announce the 2014 Elsevier/Spectrochimica Acta Award, the annual award honoring the most significant article(s) published in a volume. Elsevier makes this award on behalf of Spectrochimica Acta, Part B, to encourage the publication of top articles in this journal. All papers published during one year are considered for this award and the Editorial Advisory Board and the Guest Editor(s) of the special issue(s) are responsible for the selection. The award consists of a monetary prize of 1000 together with a presentation certificate.

  18. Elsevier/Spectrochimica Acta atomic spectroscopy award 2015

    NASA Astrophysics Data System (ADS)

    Omenetto, Nicolo; de Loos-Vollebregt, Margaretha

    2016-12-01

    This is to announce the 2015 Elsevier/Spectrochimica Acta award, the annual award honoring the most significant article(s) published in a volume. Elsevier makes this award on behalf of Spectrochimica Acta, Part B, to encourage the publication of top articles in this journal. All papers published during one year are considered for this award and the Editorial Advisory Board and the Guest Editor(s) of the special issue(s) are responsible for the selection. The award consists of a monetary prize of 1000 together with a presentation certificate.

  19. Elsevier/Spectrochimica Acta Atomic Spectroscopy Award 2013

    NASA Astrophysics Data System (ADS)

    Omenetto, Nicolo'; de Loos, Greet

    2015-01-01

    This is to announce the 2013 Elsevier/Spectrochimica Acta Award, the annual award honoring the most significant article(s) published in a volume. Elsevier makes this award on behalf of Spectrochimica Acta, Part B, to encourage the publication of top articles in this journal. All papers published during one year are considered for this award and the Editorial Advisory Board and the Guest Editor(s) of the special issue(s) are responsible for the selection. The award consists of a monetary prize of 1000 together with a presentation certificate.

  20. Advertising in Actas Dermosifiliográficas, 1909-1939.

    PubMed

    Díaz-Díaz, R M

    2014-05-01

    We review advertisements published in the journal Actas Dermosifiliográficas between 1909 and 1939. Treatments for sexually transmitted diseases were advertised with particular frequency, and they offer a case in point that exemplifies the close relationship between the pharmaceutical industry and medical journals.

  1. Aortic Disease Presentation and Outcome Associated with ACTA2 mutations

    PubMed Central

    Regalado, Ellen S.; Guo, Dongchuan; Prakash, Siddharth; Bensend, Tracy A.; Flynn, Kelly; Estrera, Anthony; Safi, Hazim; Liang, David; Hyland, James; Child, Anne; Arno, Gavin; Boileau, Catherine; Jondeau, Guillaume; Braverman, Alan; Moran, Rocio; Morisaki, Takayuki; Morisaki, Hiroko; Consortium, Montalcino Aortic; Pyeritz, Reed; Coselli, Joseph; LeMaire, Scott; Milewicz, Dianna M.

    2015-01-01

    Background ACTA2 mutations are the major cause of familial thoracic aortic aneurysms and dissections. We sought to characterize these aortic diseases in a large case series of individuals with ACTA2 mutations. Methods and Results Aortic disease, management, and outcome associated with the first aortic event (aortic dissection or aneurysm repair) were abstracted from the medical records of 277 individuals with 41 various ACTA2 mutations. Aortic events occurred in 48% of these individuals, with the vast majority presenting with thoracic aortic dissections (88%) associated with 25% mortality. Type A dissections were more common than type B dissections (54% versus 21%), but the median age of onset of type B dissections was significantly younger than type A dissections (27 years, IQR 18–41 versus 36 years, IQR 26–45). Only 12% of aortic events were repair of ascending aortic aneurysms, which variably involved the aortic root, ascending aorta and aortic arch. Overall cumulative risk of an aortic event at age 85 years was 0.76 (95% CI 0.64, 0.86). After adjustment for intra-familial correlation, gender and race, mutations disrupting p.R179 and p.R258 were associated with significantly increased risk for aortic events, whereas p.R185Q and p.R118Q mutations showed significantly lower risk of aortic events compared to other mutations. Conclusions ACTA2 mutations are associated with high risk of presentation with an acute aortic dissection. The lifetime risk for an aortic event is only 76%, suggesting that additional environmental or genetic factors play a role in expression of aortic disease in individuals with ACTA2 mutations. PMID:25759435

  2. Cerebral arteriopathy associated with Arg179His ACTA2 mutation

    PubMed Central

    Amans, Matthew R; Stout, Charles; Fox, Christine; Narvid, Jared; Hetts, Steven W; Cooke, Daniel L; Higashida, Randall T; Dowd, Christopher F; McSwain, Hugh; Halbach, Van V

    2013-01-01

    ACTA2 mutations have recently been shown to cause a multisystem smooth muscle dysfunction syndrome that may result in pediatric stroke. We report a case of ACTA2 mutation in a 3-year-old girl presenting with acute ischemic stroke and provide high resolution imaging of the cerebral arteries demonstrating novel findings of multiple tiny aneurysms (particularly in the posterior circulation), as well as the more characteristic imaging phenotype of straightened and narrowed proximal intracranial vessels, dilated cervical vessels and occlusion of the M1 MCA segment without lenticulostriate collateral formation. This newly identified disease should be added to the differential diagnosis of pediatric stroke and cerebral vasculopathy. Neuroradiologists, interventionalists, surgeons and neurologists should become familiar with this rare disease and its clinical sequelae. PMID:24293535

  3. [Substance basis research on Chinese materia medica is one of key scientific problems of inheriting, development and innovation of Chinese materia medica].

    PubMed

    Yang, Xiu-wei

    2015-09-01

    The compound Chinese materia medica is the medication pattern of the traditional Chinese medicine for the disease prevention and treatment. The single Chinese materia medica (mostly in decoction pieces) is the prescription composition of the compound Chinese materia medica. The study of the effective substance basis of Chinese materia medica should be based on the chemical compositions of the compound Chinese materia medica as an entry point considering the different status of "Monarch, Minister, Assistant, and Guide" for a certain single Chinese materia medica in the different compound Chinese materia medica while substance basis research of a certain single Chinese materia medica should be a full component analysis as well as both stable and controllable quality. Substance basis research on Chinese materia medica is one of key scientific problems of inheriting, development and innovation of Chinese materia medica.

  4. [Management of Chinese materia medica market based on information asymmetry].

    PubMed

    Yang, Guang; Wang, Nuo; Guo, Lan-Ping; Wang, Yong-Yan; Huang, Lu-Qi; Liu, Jin-Xin

    2013-12-01

    Pharmaceutical market is a typical market with information asymmetry, and which can lead to "lemons" problem. In all developed countries, firms must receive regulatory approval to market a pharmaceutical product. Such administrative department including SFDA, EMA, FDA and so on. Chinese materia medica is a special part of pharmaceutical market in China. The management of Chinese materia medica is a special challenge in China.

  5. [Influence of compendium of Materia Medica on the materia medica in the late period of the Chosun Dynasty].

    PubMed

    Oh, Chae-Kun

    2012-08-31

    In this paper, I investigated the influence of Compendium of Materia Medica (CM) on Records for Rural Life of Chosun Gentlemen (RRC), and refuted Miki Sakae's opinion, CM did not have much impact on the Materia Medica in the late period of the Chosun Dynasty. When Li Shizhen published CM, it resulted in a shift of mainstream of Materia Medica in Eastern Asia from Classified Emergency Materia Medica to CM and a new categorizing system of Materia Medica by CM led to the division of Materia Medica into medicine and natural history. It is obvious that doctors of the Chosun Dynasty also adopted the latest achievements of Materia Medica by CM, but so far there have been few studies to clarify this. Seo yugu was a scholar of the Realist School of Confucianism during the late period of the Chosun Dynasty, and RRC is his representative work. RRC is a massive encyclopedia of natural history that covers vast areas of science from agriculture, floriculture, writing and drawing, architecture, diet, and medicine, among others which absorbed the achievements of CM, the best Materia Medica book at that time. Miki Sakae also highly regarded the encyclopedic knowledge of RRC, but devalued the results of Materia Medica. He only described a part of RRC's Materia Medica, nurturing volume, on the view of life nurturing and mentioned that it had been strongly influenced by China. According to this study, a large portion of RRC, especially regarding Materia Medica, depends on CM. Seo yugu had accepted the categorizing system and new medicinal information of CM, at the same time he modified the categorizing system of CM practically by the subject of each volume of RRC. We can find many quotations of CM except the nurturing volume, but other books, Treasured Mirror of Eastern Medicine, Materia Medica for Relief of Famines are also quoted. Furthermore, Seo yugu emphasized the differences of natural environments between Chosun and China, and specified the editing criteria, "to be useful in

  6. Cardiac α-actin over-expression therapy in dominant ACTA1 disease.

    PubMed

    Ravenscroft, Gianina; McNamara, Elyshia; Griffiths, Lisa M; Papadimitriou, John M; Hardeman, Edna C; Bakker, Anthony J; Davies, Kay E; Laing, Nigel G; Nowak, Kristen J

    2013-10-01

    More than 200 mutations in the skeletal muscle α-actin gene (ACTA1) cause either dominant or recessive skeletal muscle disease. Currently, there are no specific therapies. Cardiac α-actin is 99% identical to skeletal muscle α-actin and the predominant actin isoform in fetal muscle. We previously showed cardiac α-actin can substitute for skeletal muscle α-actin, preventing the early postnatal death of Acta1 knock-out mice, which model recessive ACTA1 disease. Dominant ACTA1 disease is caused by the presence of 'poison' mutant actin protein. Experimental and anecdotal evidence nevertheless indicates that the severity of dominant ACTA1 disease is modulated by the relative amount of mutant skeletal muscle α-actin protein present. Thus, we investigated whether transgenic over-expression of cardiac α-actin in postnatal skeletal muscle could ameliorate the phenotype of mouse models of severe dominant ACTA1 disease. In one model, lethality of ACTA1(D286G). Acta1(+/-) mice was reduced from ∼59% before 30 days of age to ∼12%. In the other model, Acta1(H40Y), in which ∼80% of male mice die by 5 months of age, the cardiac α-actin transgene did not significantly improve survival. Hence cardiac α-actin over-expression is likely to be therapeutic for at least some dominant ACTA1 mutations. The reason cardiac α-actin was not effective in the Acta1(H40Y) mice is uncertain. We showed that the Acta1(H40Y) mice had endogenously elevated levels of cardiac α-actin in skeletal muscles, a finding not reported in dominant ACTA1 patients.

  7. Langkocyclines: novel angucycline antibiotics from Streptomyces sp. Acta 3034(*).

    PubMed

    Kalyon, Bahar; Tan, Geok-Yuan A; Pinto, John M; Foo, Cheau-Yee; Wiese, Jutta; Imhoff, Johannes F; Süssmuth, Roderich D; Sabaratnam, Vikineswary; Fiedler, Hans-Peter

    2013-10-01

    Langkocyclines A1-A3 and B1 and B2, five new angucycline antibiotics produced by Streptomyces sp. Acta 3034, were detected in the course of our HPLC-diode array screening. The producing strain was isolated from the rhizospheric soil of a Clitorea sp. collected from Burau Bay, Langkawi, Malaysia, and was characterized by morphological, physiological and chemotaxonomic features in addition to 16S ribosomal RNA gene sequence information. Strain Acta 3034 is closely related to Streptomyces psammoticus NBRC 13971(T) and Streptomyces lanatus NBRC 12787(T). Langkocyclines consist of an angular tetracyclic benz[a]anthracene skeleton and hydrolyzable O-glycosidic sugar moieties. The yellow-colored A-type langkocyclines differ in their aglycon from the blue-lilac-colored B-type langkocyclines. The A-type langkocycline aglycon is identical to that of aquayamycin and urdamycin A. The chemical structures of the langkocyclines were elucidated by HR-MS, 1D and 2D NMR experiments. They are biologically active against Gram-positive bacteria and exhibit a moderate antiproliferative activity against various human tumor cell lines.

  8. [Probe into monitoring mechanism of Chinese materia medica resources].

    PubMed

    Zhang, Xiao-Bo; Li, Da-Ning; Guo, Lan-Ping; Lu, Jian-Wei; Sun, Li-Ying; Huang, Lu-Qi

    2013-10-01

    Focusing on the problems of Chinese materia medica resources,and combining with the national Chinese materia medica resources survey, the paper probes into monitoring mechanism of Chinese materia medica resources. The establishment of the monitoring mechanism needs one organization and management agencies to supervise and guide monitoring work, one network system to gather data information, a group of people to perform monitoring work, a system of technical methods to assure monitoring work scientific and practical, a series of achievements and products to figure out the methods for solving problems, a group of monitoring index system to accumulate basic data, and a plenty of funds to keep normal operation of monitoring work.

  9. Acta stomatologica Croatica and PubMed Central

    PubMed Central

    Brkić, Hrvoje

    2016-01-01

    April 15 2016 marked the 50th anniversary of continuous publishing of the journal Acta stomatologica Croatica (ASCRO). The celebration was held in the great hall of the Croatian Medical Association, with numerous guests from the biomedical field. The history of the journal was presented by Goran Knežević (editor-in-chief 1996-2006) and Hrvoje Brkić (current editor-in-chief), who presented all the current information on the electronical editing and its current indexation. Only a few days later, the Editorial Office received the information that ASCRO has been included in PubMed Central since volume 48, an impulse for the members of the Editorial Board and the Editor-in-Chief to make ASCRO better and more cited PMID:27789906

  10. [Consideration for understanding and developing Chinese materia medica].

    PubMed

    Yin, Zhong

    2008-02-01

    To understand and develop Chinese materia medica is a matter not only dealing with progresses of science and technology but also with that of bio-science. In the area of life-science, the activity of human life-science is the most complicated one which is far away to be satisfactorily explained with existing knowledge of science. Therefore, it is much insufficient to explain and qualify the interreaction between Chinese materia medica and process of human-life with knowledge of general science and non-fully developed bioscience. To understand and develop Chinese materia medica is also matter dealing with many issues of social science. In terms of epistemology, it is necessary to consider how to make some social adjustment for scientific practice and drug registration of Chinese materia medica, under precondition of balance among science, life-science, technology, ethics and philosophy.

  11. Medicaments as the possible cause of urticaria in children.

    PubMed

    Balaban, Jagoda

    2002-09-01

    Medicaments are reported as the most common cause of urticaria. The objective of this study was to determine, by retrospective analysis of 132 pediatric patients treated at the Pulmonology and Allergology ward of the Department of Pediatrics, Banja Luka, over a 5-year period, the scope to which medicaments act as the possible cause of urticaria. Results of the study showed that the disease manifested mostly in male children (59.8), mainly of pre-school and school age rather than <1 year age group. Acute urticaria predominated, and it was recorded in 91.7% of cases. A medicament as the possible etiologic factor of acute urticaria was found in 29.8% of cases. Regarding chronic urticaria, in most cases the cause of disease remained unknown (63.6%), whereas a medicament and infection as the possible causal factors were found in 9.1% of cases. Before the occurrence of urticaria, 37 (28%) children took some medicament. Usually, these were antibiotics (45.9%), antipyretics (35.1%), or a combination of antibiotics and antipyretics (16.2%). Penicillin V, G or ampicillin were the most frequently used antibiotics (88.2%), whereas acetylsalicylic acid was the most frequently used antipyretic (53.8%). In 28% of the children suffering from acute urticaria, apart from taking some medicament, clinically manifested infection was also recorded, mostly of the respiratory system, so it could not be stated for sure whether the medicament or infection was the etiologic factor for the occurrence of disease. In only two cases it could be stated for sure that a medicament was the cause of urticaria, one acute and chronic urticaria each

  12. [The introduction of compendium of materia medica and praxis in the late Joseon dynasty].

    PubMed

    Oh, Chaekun; Kim, Yongjin

    2011-06-30

    Sakae Miki said Classified Emergency Materia Medica had been the dominant standard of herbology throughout Joseon Dynasty, and that Compendium of Materia Medica had only been accepted so lately that a few books used herbological result of it in the late Joseon Dynasty. But according to Visiting Old Beijing Diary written by Munjoong Seo in 1690, Compendium of Materia Medica was in fact introduced before the year 1712, the year Miki Sakae argued to be the year Compendium of Materia Medica was accepted to Joseon officially. Now, we can assume that the introducing year of Compendium of Materia Medica was faster than Miki Sakae's opinion by the following reasons; the effort of Joseon government and intellectuals to buy new books of Ming & Ching; the publishing year of the book for living in countryside regarded as the first citing literature of Compendium of Materia Medica. And the True Records of the Joseon Dynasty and many collections written by intellectuals in the 18th century show that the herbological knowledge from Compendium of Materia Medica had already spread to the corners of Joseon Dynasty. Thus we can make the following assumption: Classified Emergency Materia Medica and Compendium of Materia Medica had coexisted in the late Joseon Dynasty. Sakae Miki suggested 6 examples which used Compendium of Materia Medica in the late Joseon Dynasty. I reviewed two of them in this paper, Essentials of Materia Medica & Handbook of Prescriptions from Materia Medica. Essentials of Materia Medica quoted Compendium of Materia Medica briefly focusing clinical use, and Handbook of Prescriptions from Materia Medica also re-compiled Compendium of Materia Medica to practical use according to the form of Treasured Mirror of Eastern Medicine. It means that the results of Compendium of Materia Medica have been used positively, based on the herbology of materia medica from countryside. From this point of view, the hyphothesis there weren't any herbological progress after accepting

  13. Acta Clinica Croatica: progress of a journal step by step.

    PubMed

    Ramljak, Gordana

    2014-03-01

    The journal Acta Clinica Croatica (ACC) was founded in 1962 under the title Anali Bolnice Dr. M. Stojanović. In 1995, the title of the journal was changed into its present form and ever since all papers have been published in English. In 2000, the electronic (online) edition of the ACC was released in addition to the print version. The paper presents development of the journal from 1962 to 2012 based on the analysis of the following SCOPUS citation index parameters: type and number of documents published in the journal; number of citations; and number of domestic and foreign authors. The studied period was analyzed in three time segments: the period from 1995 to 1999, the period from 2000 to 2006 and the period from 2007 to 2012. The same parameters were analyzed in the Web of Science/SCI-Expanded bibliographic and citation index for the 2007-2012 period. The increasing number of documents, authors (both domestic and foreign) and citations demonstrates gradual rise in the quality, visibility and impact of the journal. The fifty years of experience show that a goal, at first very distant and almost unachievable, may be reached by progressing step by step.

  14. Pulpotomy Medicaments used in Deciduous Dentition: An Update.

    PubMed

    Al-Dlaigan, Yousef H

    2015-06-01

    The aim of this paper was to review the history and the scientific literature published on pulpotomy medicaments and to present the findings of these studies. The review showed that pulpotomy of primary teeth has been treated with many different techniques and medicaments, that some of these approaches are controversial and that their results have presented variables of success rates in term of clinical, radiographic and histologic observation. It is important that all clinicians, particularly for pediatric dentists, be up to date with the recent trends in this area of dental treatment for children.

  15. The current global status of Chinese materia medica.

    PubMed

    Liu, Xinmin; Zou, Jiangqiang; Sheng, Zhixiang; Su, Guangqiang; Chen, Shilin

    2009-10-01

    The Chinese government has recently established a national project to improve the standards of Chinese Materia Medica (CMM) products, particularly regarding their quality control and safety evaluation, in order to promote modernization and increase international trade. In 2006, the global sales value of Chinese medicinal products increased to 20 billion US$, and the export value of CMM was up to more than 1 billion US$. However, the standard of these products still needs to be improved to meet the more stringent requirements of the international markets. Over the past decade we have witnessed the increasing growth in popularity of health foods and herbal medicinal products, especially Chinese Materia Medica products (CMM).

  16. Acute aortic dissections with pregnancy in women with ACTA2 mutations.

    PubMed

    Regalado, Ellen S; Guo, Dong-chuan; Estrera, Anthony L; Buja, L Maximilian; Milewicz, Dianna M

    2014-01-01

    Mutations in ACTA2 predispose to thoracic aortic aneurysms and dissection as well as coronary artery and cerebrovascular disease. Here we examined the risk of aortic dissections, stroke and myocardial infarct with pregnancy in women with ACTA2 mutations. Of the 53 women who had a total of 137 pregnancies, eight had aortic dissections in the third trimester or the postpartum period (6% of pregnancies). One woman also had a myocardial infarct that occurred during pregnancy that was independent of her aortic dissection. Compared to the population-based frequency of peripartum aortic dissections of 0.6%, the rate of peripartum aortic dissections in women with ACTA2 mutations is much higher (8 out of 39; 20%). Six of these dissections initiated in the ascending aorta (Stanford type A), three were fatal. Three women had ascending aortic dissections at diameters less that 5.0 cm (range 3.8-4.7 cm). Aortic pathology showed mild to moderate medial degeneration of the aorta in three women. Of note, five of the women had hypertension either during or before the pregnancy. In summary, the majority of women with ACTA2 mutations did not have aortic or other vascular complications with pregnancy. However, these findings show that pregnancy is associated with significant risk for aortic dissection in women with ACTA2 mutations. Women with ACTA2 mutations who are planning to get pregnant should be counseled about this risk of aortic dissection, and proper clinical management should be initiated to reduce this risk.

  17. Technology evaluation: TroVax, Oxford BioMedica.

    PubMed

    Reinis, Milan

    2004-08-01

    TroVax, a gene-based tumor vaccine that uses a poxvirus vector to deliver the tumor antigen gene 5T4, is under development by Oxford BioMedica for the potential treatment of cancer. TroVax is undergoing phase II clinical trials.

  18. [Study on sociocultural history of therapeutic efficacy and processing of chinese materia medica].

    PubMed

    Zheng, Jin-Sheng

    2006-10-01

    The historical evolving examples of the confirmation of therapeutic efficacy of some Chinese materia medica, the social fashion of using medicine, and the processing methods of Chinese materia medica indicate that the social trend of thoughts, customs and economic factors in different ages affected the various aspects of Chinese materia medica. So, Chinese materia medica possesses very outstanding social and cultural features. Not all the actions of Chinese materia medica recorded came from the experiences of doctors. The understanding level to the nature in different ages decides what kind of drugs they would accept. There are three kinds of drug processing in ancient times: effective medicinal processing, fantastic Taoist processing and invalid trading processing. Based on the study of sociocultural history of therapeutic efficacy and processing of Chinese materia medica. It is crucial that the history and medical literature research on Chinese materia medica and pharmacy should be raised to the position as important as clinical and experiment researches.

  19. Bacterial Shape and ActA Distribution Affect Initiation of Listeria monocytogenes Actin-Based Motility

    PubMed Central

    Rafelski, Susanne M.; Theriot, Julie A.

    2005-01-01

    We have examined the process by which the intracellular bacterial pathogen Listeria monocytogenes initiates actin-based motility and determined the contribution of the variable surface distribution of the ActA protein to initiation and steady-state movement. To directly correlate ActA distributions to actin dynamics and motility of live bacteria, ActA was fused to a monomeric red fluorescent protein (mRFP1). Actin comet tail formation and steady-state bacterial movement rates both depended on ActA distribution, which in turn was tightly coupled to the bacterial cell cycle. Motility initiation was found to be a highly complex, multistep process for bacteria, in contrast to the simple symmetry breaking previously observed for ActA-coated spherical beads. F-actin initially accumulated along the sides of the bacterium and then slowly migrated to the bacterial pole expressing the highest density of ActA as a tail formed. Early movement was highly unstable with extreme changes in speed and frequent stops. Over time, saltatory motility and sensitivity to the immediate environment decreased as bacterial movement became robust at a constant steady-state speed. PMID:15980176

  20. Beitraege zur Astronomiegeschichte, Band 5 (Acta Historica Astronomiae Vol. 18)

    NASA Astrophysics Data System (ADS)

    Duerbeck, H. W.; Dick, W. R.; Hamel, J.

    2003-01-01

    The 18th volume of the Acta Historica Astronomiae is at the same time the sixth collection of essays on the history of astronomy ("Beitræge zur Astronomiegeschichte, Band 6"), edited by the historians of astronomy W.R. Dick (Potsdam) and J. Hamel (Berlin). Besides a few short notices and book reviews, the book contains eight major articles, which deal with astronomical topics covering the time from the 16th to the 19th centuries. The first article by Michael Weichenhan (Berlin) deals with "the invention of the disk-shaped earth: a chapter of Copernican apologetics". The author shows that the concept of a "disc-shaped Earth" was by no means widespread in the middle ages, but restricted to the father of the church Lactantius and some adherents. Nevertheless, it was used by adherents of Copernicus to show the absurd consequences of a strictly literal biblical interpretation -- here concerning the Earth's shape, disc versus sphere, there the geocentric versus the heliocentric system. This thorough philosophical study is followed by two very short articles. "The measuring accuracy of Tycho's large sextant" by Johann Wünsch investigates O-C values of planet-star distances, as based on Tycho's observations as published in the Historia Coelestis (a compilation, which is also based on Tycho's manuscripts, and published in Regensburg in 1672). The result is that standard deviations are 80 arcseconds for Saturn and 89 arcseconds for Jupiter and Mars, an unexpectedly poor result in view of the general opinion that Tycho was famous for his precision work. "The astronomer Christoph Grienberger and the Galilei trial" by Franz Daxecker deals with a Jesuit astronomer who was both the disciple and successor of the mathematician-astronomer Christopher Clavius at the Collegium Romanum. While he was inclined to Galilei early on, he was forced to propagate Aristotelian doctrine. The brief article is very concise, but extremely tiresome to read (3 pages of pure text are embellished by

  1. [Ecological agriculture: future of Good Agriculture Practice of Chinese materia medica].

    PubMed

    Guo, Lan-ping; Zhou, Liang-yun; Mo, Ge; Wang, Sheng; Huang, Lu-qi

    2015-09-01

    Based on the ecological and economic problems in Good Agriculture Practice (GAP) of Chinese material medica, we introduced the origin, concept, features and operative technology of eco-agriculture worldwide, emphasizing its modes on different biological levels of landscape, ecosystem, community, population, individual and gene in China. And on this basis, we analyzed the background and current situation of eco-agriculture of Chinese materia medica, and proposed its development ideas and key tasks, including: (1) Analysis and planning of the production pattern of Chinese material medica national wide. (2) Typical features extraction of regional agriculture of Chinese materia medica. (3) Investigation of the interaction and its mechanism between typical Chinese materia medica in each region and the micro-ecology of rhizosphere soil. (4) Study on technology of eco-agriculture of Chinese materia medica. (5) Extraction and solidification of eco-agriculture modes of Chinese materia medica. (6) Study on the theory of eco-agriculture of Chinese materia medica. Also we pointed out that GAP and eco-agriculture of Chinese material medica are both different and relative, but they are not contradictory with their own features. It is an irresistible trend to promote eco-agriculture in the GAP of Chinese material medica and coordinate ecological and economic development.

  2. [Construction of biopharmaceutics classification system of Chinese materia medica].

    PubMed

    Liu, Yang; Wei, Li; Dong, Ling; Zhu, Mei-Ling; Tang, Ming-Min; Zhang, Lei

    2014-12-01

    Based on the characteristics of multicomponent of traditional Chinese medicine and drawing lessons from the concepts, methods and techniques of biopharmaceutics classification system (BCS) in chemical field, this study comes up with the science framework of biopharmaceutics classification system of Chinese materia medica (CMMBCS). Using the different comparison method of multicomponent level and the CMMBCS method of overall traditional Chinese medicine, the study constructs the method process while setting forth academic thoughts and analyzing theory. The basic role of this system is clear to reveal the interaction and the related absorption mechanism of multicomponent in traditional Chinese medicine. It also provides new ideas and methods for improving the quality of Chinese materia medica and the development of new drug research.

  3. [Study on Shi Zhenduo's Ben cao bu (Supplemented materia medica)].

    PubMed

    Zhen, Xueyan; Zheng, Jinsheng

    2002-10-01

    Being called "precursor of pharmacy imported from the west" by Fan Xingzhun, a famous medical historian, Ben cao bu was lost in China. It has been found outside China recently. This article deals with the author, blockprinting edition, contents of the book and makes a comparison with its texts cited in Ben cao gang mu shi yi (Supplemented Compendium of Materia Medica). It also evaluates the practical significance of this book as an early dissemination of pharmacy imported from the west.

  4. Acta Dermatovenerologica Alpina, Pannonica et Adriatica accepted for coverage in Thomson Reuters' Emerging Sources Citation Index (ESCI).

    PubMed

    Poljak, Mario; Miljković, Jovan; Triglav, Tina

    2016-09-01

    Acta Dermatovenerologica Alpina, Pannonica et Adriatica (Acta Dermatovenerol APA) is the leading journal in dermatology and sexually transmitted infections in the region. Several important steps were taken during the last 25 years to improve the journal's quality, global visibility, and international impact. After a 1-year trial period, Thomson Reuters recently informed the editorial office that they had accepted Acta Dermatovenerol APA for coverage in Thomson Reuters' new index in the Web of Science Core Collection called the Emerging Sources Citation Index (ESCI). The coverage of Acta Dermatovenerol APA begins with the journal content published online in 2016; that is, from volume 25 onwards.

  5. Acute Aortic Dissections with Pregnancy in Women with ACTA2 Mutations

    PubMed Central

    Regalado, Ellen S.; Guo, Dong-chuan; Estrera, Anthony L.; Buja, L. Maximilian; Milewicz, Dianna M.

    2014-01-01

    Mutations in ACTA2 predispose to thoracic aortic aneurysms and dissections as well as coronary artery and cerebrovascular disease. Here we examined the risk of aortic dissections, stroke and myocardial infarct with pregnancy in women with ACTA2 mutations. Of the 53 women who had a total of 137 pregnancies, eight had aortic dissections in the third trimester or the postpartum period (6% of pregnancies). One woman also had a myocardial infarct that occurred during pregnancy that was independent of her aortic dissection. Compared to the population-based frequency of peripartum aortic dissections of 0.6%, the rate of peripartum aortic dissections in women with ACTA2 mutations is much higher (8 out of 39; 20%). Six of these dissections initiated in the ascending aorta (Stanford type A), three of which were fatal. Three women had ascending aortic dissections at diameters less that 5.0 cm (range 3.8 to 4.7 cm). Aortic pathology showed mild to moderate medial degeneration of the aorta in three women. Of note, five of the women had hypertension either during or before the pregnancy. In summary, the majority of women with ACTA2 mutations did not have aortic or other vascular complications with pregnancy. However, these findings show that pregnancy is associated with significant risk for aortic dissections in women in whom diagnosis of ACTA2 mutation has not been made. Women with ACTA2 mutations who are planning to get pregnant should be counseled about this risk of aortic dissections, and proper clinical management should be initiated to reduce this risk. PMID:24243736

  6. A novel distinctive cerebrovascular phenotype is associated with heterozygous Arg179 ACTA2 mutations

    PubMed Central

    Munot, Pinki; Saunders, Dawn E.; Milewicz, Dianna M.; Regalado, Ellen S.; Ostergaard, John R.; Braun, Kees P.; Kerr, Timothy; Lichtenbelt, Klaske D.; Philip, Sunny; Rittey, Christopher; Jacques, Thomas S.; Cox, Timothy C.

    2012-01-01

    Mutations in the ACTA2 gene lead to diffuse and diverse vascular diseases; the Arg179His mutation is associated with an early onset severe phenotype due to global smooth muscle dysfunction. Cerebrovascular disease associated with ACTA2 mutations has been likened to moyamoya disease, but appears to have distinctive features. This study involved the analysis of neuroimaging of 13 patients with heterozygous missense mutations in ACTA2 disrupting Arg179. All patients had persistent ductus arteriosus and congenital mydriasis, and variable presentation of pulmonary hypertension, bladder and gastrointestinal problems associated with this mutation. Distinctive cerebrovascular features were dilatation of proximal internal carotid artery, occlusive disease of terminal internal carotid artery, an abnormally straight course of intracranial arteries, and absent basal ‘moyamoya’ collaterals. Patterns of brain injury supported both large and small vessel disease. Key differences from moyamoya disease were more widespread arteriopathy, the combination of arterial ectasia and stenosis and, importantly, absence of the typical basal ‘moyamoya’ collaterals. Evaluation of previously published cases suggests some of these features are also seen in the ACTA2 mutations disrupting Arg258. The observation that transition from dilated to normal/stenotic arterial calibre coincides with where the internal carotid artery changes from an elastic to muscular artery supports the hypothesis that abnormal smooth muscle cell proliferation caused by ACTA2 mutations is modulated by arterial wall components. Patients with persistent ductus arteriosus or congenital mydriasis with a label of ‘moyamoya’ should be re-evaluated to ensure the distinctive neuroimaging features of an ACTA2 mutation have not been overlooked. This diagnosis has prognostic and genetic implications, and mandates surveillance of other organ systems, in particular the aorta, to prevent life-threatening aortic dissection

  7. Discoloration of Roots Caused by Residual Endodontic Intracanal Medicaments

    PubMed Central

    Chen, Belinda Kuan-Jung; Walsh, Laurence James

    2014-01-01

    Aims. This study examined the extent to which intervisit corticosteroid-based antibiotic pastes (CAP) medicaments contribute to staining of tooth structure after attempted removal by irrigation techniques. Methods. A total of 140 roots were prepared and the canals were filled with Ledermix paste (demeclocycline), Odontopaste (clindamycin), and Doxypaste (doxycycline). The pastes were removed after 2 or 4 weeks of storage in the dark using EDTA and NaOCl with either a 27-gauge-slotted needle or an EndoActivator (Dentsply). The roots were then exposed to an intense light source for 30 minutes each week and photographed after a further 1, 3, or 6 months. Digital images were standardized and data for changes in luminosity were analysed using repeated measures ANOVA and a post hoc test. Results. Removal of the medicament did not prevent later discolouration. There was no significant difference between the paste removal methods. Ledermix paste caused the greatest darkening compared to the untreated controls, for both application periods and both methods of removal. Doxypaste and Odontopaste caused less darkening than Ledermix. Conclusion. Medicaments that stain teeth may continue to discolour teeth despite best attempts to remove them. This study stresses the importance of material selection and minimising contact of Ledermix within the coronal aspects of teeth. PMID:24688386

  8. De Novo ACTA2 Mutation Causes a Novel Syndrome of Multisystemic Smooth Muscle Dysfunction

    PubMed Central

    Milewicz, Dianna M.; Østergaard, John R.; Ala-Kokko, Leena M.; Khan, Nadia; Grange, Dorothy K.; Mendoza-Londono, Roberto; Bradley, Timothy J.; Olney, Ann Haskins; Adès, Lesley; Maher, Joseph F.; Guo, Dongchuan; Buja, L. Maximilian; Kim, Dong; Hyland, James C.; Regalado, Ellen S.

    2011-01-01

    Smooth muscle cells (SMCs) contract to perform many physiological functions, including regulation of blood flow and pressure in arteries, contraction of the pupils, peristalsis of the gut and voiding of the bladder. SMC lineage in these organs is characterized by cellular expression of the SMC isoform of α-actin, encoded by the ACTA2 gene. We report here on a unique and de novo mutation in ACTA2, R179H, that causes a syndrome characterized by dysfunction of SMCs throughout the body, leading to aortic and cerebrovascular disease, fixed dilated pupils, hypotonic bladder, malrotation and hypoperistalsis of the gut and pulmonary hypertension. PMID:20734336

  9. [Elementary exploration of the origin and development of marine Chinese materia medica].

    PubMed

    Guan, Hua-Shi; Fu, Xian-Jun; Wu, Qiang-Ming; Wang, Chang-Yun; Wang, Yu; Jiang, Deng-Zhao

    2009-05-01

    According to archaeological discoveries, humans began to make use of marine natural resources early in the Palaeolithic era. In the Spring and Autumn period and Warring States period, they began to use marine life as medicines and also had simple cognitions on their efficacy and processing. In the Qin and Han dynasties, people further deepened the understanding of the marine Chinese materia medica and created prescriptions making use of marine drugs. In the Tang and Song period, the number of marine Chinese materia medica species and corresponding prescriptions apparently increased. The cognitions of the property, flavor, efficacy as well as the compatible principle of marine Chinese materia medica was further deepened and the scope of their treatment also significantly expanded. In the Ming and Qing dynasties, the cognition of the marine Chinese materia medica was mainly the conclusions of the previous experience. After the founding of the People's Republic of China (PRC), with the development of science and technologies, the ability of exploiting and utilizing the marine Chinese materia medica by people dramatically increased, and the species of marine Chinese materia medica reached more than one thousand. However, the development of marine Chinese materia medica is confronted with new problems; although the number of species of marine Chinese materia medica increased, the understanding of their property and flavor is obviously lagging behind, which seriously affects the clinical application of marine Chinese materia medica.

  10. [Application of zebrafish model organism in the research of Chinese materia medica].

    PubMed

    Chen, Lei; Liu, Yi; Liang, Sheng-Wang

    2012-04-01

    Zebrafish has become an important model organism in many fields of biomedical studies and been increasingly used in Chinese materia medica studies in recent years. This article summarized the achievements and prospect for zebrafish as a pharmacological and toxicological tool in the study and development of Chinese materia medica.

  11. [Application of synthetic biology to sustainable utilization of Chinese materia medica resources].

    PubMed

    Huang, Lu-Qi; Gao, Wei; Zhou, Yong-Jin

    2014-01-01

    Bioactive natural products are the material bases of Chinese materia medica resources. With successful applications of synthetic biology strategies to the researches and productions of taxol, artemisinin and tanshinone, etc, the potential ability of synthetic biology in the sustainable utilization of Chinese materia medica resources has been attracted by many researchers. This paper reviews the development of synthetic biology, the opportunities of sustainable utilization of Chinese materia medica resources, and the progress of synthetic biology applied to the researches of bioactive natural products. Furthermore, this paper also analyzes how to apply synthetic biology to sustainable utilization of Chinese materia medica resources and what the crucial factors are. Production of bioactive natural products with synthetic biology strategies will become a significant approach for the sustainable utilization of Chinese materia medica resources.

  12. [Research on nature of Chinese materia medica in view of genetic relationship].

    PubMed

    Yang, Hong-Jun; Tang, Shi-Huan; Huang, Lu-Qi; Xiao, Pei-Gen

    2008-12-01

    In this paper, based on analyzing the status quo and key problem of research on nature of Chinese materia medica, we propose the thinking of research on nature of Chinese materia medica in view of genetic relationship. Namely, according to the cue of documents arrangement and data excavation, in certern scope of genetic relationship, difinite the common pharmaco-effect of the same nature of drug, and analyze the chemical composition correlated the nature of drug, further more, reveal the related regularity of nature of Chinese materia medica-pharmaco-effect- chemical composition. Linking the nature of Chinese materia medica, pharmaco-effect and chemical composition will provide original thinking and view angle to break through the key problem of research on nature of Chinese materia medica.

  13. [Analysis of complexity in Chinese meteria medica industrial chain].

    PubMed

    Liu, Ying; Li, Qi; Wang, Xiao-Fan

    2014-08-01

    Chinese meteria medica (CMM) chain is a long-span chain covering agriculture which mainly depends on the forces of nature as well as high-tech CMM industry, CMM expertise industry and fast developing CMM circulation industry. Imbalance among the development of these industries produces bottlenecks and hinders the operation of the entire production chain. After analyzing the structure of Chinese meteria medica industrial chain from the perspective of national economy industry, three industry classifications and differentiation of factor intensity, we conclude that the complex structure of CMM industry chain is attributable to these three aspects. And the complexity is mainly shown at complex industry, varied product types, different coordination of various industrial sections and different technical growth speed of varied industry. We propose that structural complexity is the natural property of the chain, which is the main reason of industry sector development imbalance and bottleneck. Results of this research could provide theoretical analysis for future research on the coordination of industrial chain and the efficiency of resource allocation.

  14. Review of adverse reactions to injections of Chinese materia medica.

    PubMed

    Bian, Zhaoxiang; Shang, Hongcai; Cheng, Chungwah; Wu, Taixiang; Li, Youping; Zhang, Boli

    2010-05-01

    Using Chinese Materia Medica (CM) as injections is an innovation that is proving effective in extensive clinical use in Mainland China. However, recent reports have focused on adverse reactions, ignoring the considerable successes of these preparations. In order to achieve balance in the media and in the minds of the public, we suggest the first step is to clarify the concepts of and differences between adverse drug reactions (ADR) and adverse events (AE) for all concerned-the public, medical practitioners, government officials, and lawmakers. Second, the State Food and Drug Administration should raise the requirements for Chinese Materia Medica Injection (CMI) registration and license approval and emphasize the importance of evidence-based CMI development and evidence-based CMI license approval. Thirdly, drug companies and institutions should reinforce basic research about the quality control of herbs and CMI-drug interactions. Fourth, the Government should clarify the legal responsibilities for CMI approval agencies, CMI developers, medical doctors, and patients. Fifth, the medical association and Government should enhance training for health care professionals concerning the usage of CMIs. And finally sixth, State Food and Drug Administration should monitor the content and quality of the directions for use of CMI.

  15. Citation analysis of Acta Dermatovenerologica Alpina, Pannonica et Adriatica: 1992-2011.

    PubMed

    Ostrbenk, Anja; Skamperle, Mateja; Poljak, Mario

    2012-09-01

    Acta Dermatovenerologica Alpina, Pannonica et Adriatica is small regional professional journal that started publishing in 1992. Despite the journal's relatively narrow readership, it has significantly improved its quality and global profile during the last 20 years, as shown in this citation analysis update. Since 1992, 654 bibliographical items have been published. Among these, 545 (83.4%) were considered WoS citable items and 109 (16.6%) WoS noncitable items. Since 2008, 90% of all published items have been considered WoS citable items and received an average of 1.9 citations per item. The predicted Acta Dermatovenerol APA impact factor calculated using data from a Cited Reference search of Thomson Scientific's Web of Science has shown steep and continuous increase since 2006, when the journal acquired full indexing status in Index Medicus/Medline, and has been above 0.5 since 2008.

  16. Novel MYH11 and ACTA2 mutations reveal a role for enhanced TGFβ signaling in FTAAD

    PubMed Central

    Renard, Marjolijn; Callewaert, Bert; Baetens, Machteld; Campens, Laurence; MacDermot, Kay; Fryns, Jean-Pierre; Bonduelle, Maryse; Dietz, Hal; Gaspar, Isabel Mendes; Cavaco, Diogo; Stattin, Eva-Lena; Schrander-Stumpel, Constance; Coucke, Paul; Loeys, Bart; De Paepe, Anne; De Backer, Julie

    2011-01-01

    Background Thoracic aortic aneurysm / dissection (TAAD) is a common phenotype that may occur as an isolated manifestation or within the constellation of a defined syndrome. In contrast to syndromic TAAD, the elucidation of the genetic basis of isolated TAAD has only recently started. To date, defects have been found in genes encoding extracellular matrix proteins (fibrillin-1, FBN1; collagen type III alpha 1, COL3A1), proteins involved in transforming growth factor beta (TGFβ) signaling (TGFβ receptor 1 and 2, TGFBR1/2; and SMAD3) or proteins that build up the contractile apparatus of aortic smooth muscle cells (myosin heavy chain 11, MYH11; smooth muscle actin alpha 2, ACTA2; and MYLK). Methods and results In 110 non-syndromic TAAD patients that previously tested negative for FBN1 or TGFBR1/2 mutations, we identified 7 ACTA2 mutations in a cohort of 43 familial TAAD patients, including 2 premature truncating mutations. Sequencing of MYH11 revealed an in frame splice-site alteration in one out of two probands with TAA(D) associated with PDA but none in the series of 22 probands from the cohort of 110 patients with non-syndromic TAAD. Interestingly, immunohistochemical staining of aortic biopsies of a patient and a family member with MYH11 and patients with ACTA2 missense mutations showed upregulation of the TGFβ signaling pathway. Conclusions MYH11 mutations are rare and typically identified in patients with TAAD associated with PDA. ACTA2 mutations were identified in 16% of a cohort presenting familial TAAD. Different molecular defects in TAAD may account for a different pathogenic mechanism of enhanced TGFβ signaling. PMID:21937134

  17. [National and international impact factor of Actas Españolas de Psiquiatría].

    PubMed

    Aleixandre Benavent, R; Valderrama Zurián, J C; Castellano Gómez, M; Simó Meléndez, R; Navarro Molina, C

    2004-01-01

    The aim of this paper is to present the bibliometric indicators of Actas Españolas de Psiquiatría that were obtained from the study "Potential impact factor of the Spanish medical journals in 2001", financed by the Spanish Ministerio de Educación, Cultura y Deporte. The citations made in Actas Españolas de Psiquiatría and its national and international impact factor and immediacy index have been obtained by the use of a methodology similar to the one used by the Institute for Scientific Information. The national indicators only take into account the citations made in 87 Spanish journals considered as sources, while those from the foreign source journals of Science Citation Index have been added to the previously cited ones. Actas Españolas de Psiquiatría has obtained a national impact factor of 0.315 and an international impact factor of 0.395, which places it as a leader in the Spanish psychiatric journals.

  18. [Popular knowledge about medicaments in 19th century periodicals].

    PubMed

    Arabas, Iwona

    2004-01-01

    Polish periodicals published since the beginning of 19th century contained household knowledge which was of great importance to peasants. In the second half of 19th century the number of articles related to prevention, treatment as well as life hygiene (including nutrition guidance) enlarged significantly. The term "household medicine box# was very often used in periodicals as titles of both: sections dedicated to hygiene or medicine as well as for articles describing medicaments intended to be kept in the boxes. Articles referenced law regulations stated in "law for pharmacists and pharmacies# from 1844. The availability of medical handbooks widened with the end of the century and this fact may have caused the changes in profiles of numerous medical sections in popular periodicals. However the changes did not affect publications related to contents of medical boxes.

  19. [Japanese monograph of dietary Chinese materia medica: Ben chao shi jian].

    PubMed

    Zhou, Min

    2009-01-01

    Ben chao shi jian was a monograph of dietary Chinese materia medica written by Japanese doctor: [see text], following the style of Ben cao gang mu (Compendium of Materia Medica). The book consulted Ben cao gang mu and associated with the actual situation of Japan, making elaborate illustrations on the function, toxicity, form feature, manufacture and collection of 442 kinds of dietary Chinese material medica produced from Japan and combining organically with all kinds of knowledges including medicice and pharmacology, health preservation, nutriology and gastrology etc. It was a very important work in the developmental history of dietology and medicative dietology in Japan with high practical and academic values.

  20. Association of ActA to Peptidoglycan Revealed by Cell Wall Proteomics of Intracellular Listeria monocytogenes*

    PubMed Central

    García-del Portillo, Francisco; Calvo, Enrique; D'Orazio, Valentina; Pucciarelli, M. Graciela

    2011-01-01

    Listeria monocytogenes is a Gram-positive intracellular bacterial pathogen that colonizes the cytosol of eukaryotic cells. Recent transcriptomic studies have revealed that intracellular L. monocytogenes alter expression of genes encoding envelope components. However, no comparative global analysis of this cell wall remodeling process is yet known at the protein level. Here, we used high resolution mass spectrometry to define the cell wall proteome of L. monocytogenes growing inside epithelial cells. When compared with extracellular bacteria growing in a nutrient-rich medium, a major difference found in the proteome was the presence of the actin assembly-inducing protein ActA in peptidoglycan purified from intracellular bacteria. ActA was also identified in the peptidoglycan of extracellular bacteria growing in a chemically defined minimal medium. In this condition, ActA maintains its membrane anchoring domain and promotes efficient bacterial entry into nonphagocytic host cells. Unexpectedly, Internalin-A, which mediates entry of extracellular L. monocytogenes into eukaryotic cells, was identified at late infection times (6 h) as an abundant protein in the cell wall of intracellular bacteria. Other surface proteins covalently bound to the peptidoglycan, as Lmo0514 and Lmo2085, were detected exclusively in intracellular and extracellular bacteria, respectively. Altogether, these data provide the first insights into the changes occurring at the protein level in the L. monocytogenes cell wall as the pathogen transits from the extracellular environment to an intracytosolic lifestyle inside eukaryotic cells. Some of these changes include alterations in the relative amount and the mode of association of certain surface proteins. PMID:21846725

  1. [Discuss on effect of physical environmental factors on nature of Chinese materia medica].

    PubMed

    Tang, Shihuan; Yang, Hongjun; Huang, Luqi

    2010-01-01

    Nature of Chinese materia medica is the nucleus in the theory of Chinese material medica, according to the recognition of Traditional Chinese Medicine, which is the character of the drug related on curative effect. Nature and efficacy of a drug is through the medical material, then, physical environment, including the temperature, humidity, atmospheric water, wind, topography, soil, micro-organism, and so on, influence the growth and development of the medical meterial. In this paper, we researched the explanation on nature of Chinese materia medica in the medical books of past dynasties, combined with the modem research, analyzed the relationship between generative reception and physical environmental factors, and discussed the effect of physical environmental factors on nature of Chinese materia medica. We indicated that the formation of Chinese materia medical nature is that the drug receptive the change of physical environmental factors, and resulted by the synthetic action of the factors, such as climate, soil, biology, topography, etc.

  2. Medicinal plants for the treatment of urogenital tract pathologies according to Dioscorides' De Materia Medica.

    PubMed

    Touwaide, A; Pollio, A; Aliotta, G; Piomelli, D; De Santo, N G

    1997-01-01

    The De Materia Medica of the Greek Dioscorides reports about 200 plants used for the treatment of pathologies of the urogenital tract during the 1st century AD. On the basis of explicit and implicit affirmations by Dioscorides, a theoretical system concerning the specific properties of these plants has been attempted. Comparison of the species reported by Dioscorides and Pliny the Elder for renal affections does not support the thesis of a close relationship between De Materia Medica and the Naturalis Historia.

  3. Twins with progressive thoracic aortic aneurysm, recurrent dissection and ACTA2 mutation.

    PubMed

    Ware, Stephanie M; Shikany, Amy; Landis, Benjamin J; James, Jeanne F; Hinton, Robert B

    2014-10-01

    Thoracic aortic aneurysm (TAA) is a genetically mediated disease with variable age of onset. In the pediatric age range, nonsyndromic TAA frequently has a milder course than syndromic forms of TAA, such as Marfan syndrome or Loeys-Dietz syndrome. Herein, we describe 17-year-old identical twin brothers with severe progressive TAA due to a novel de novo ACTA2 mutation. Interestingly, both boys were diagnosed at age 11 with congenital mydriasis, a recently recognized manifestation of some ACTA2 mutations due to smooth muscle dysfunction. One of the brothers presented with acute-onset lower back pain that was identified as dissection of an abdominal aortic aneurysm. Imaging of the chest at this time showed severe fusiform TAA. Cardiac imaging in his twin showed similar TAA, but no abdominal aortic aneurysm. Both brothers underwent valve-sparing aortic root replacement, but have had progressive aortic disease with recurrent dissection requiring multiple surgeries. This case emphasizes the importance of identifying physical stigmata of smooth muscle dysfunction, such as mydriasis, as potential markers for associated aortopathy and vascular diseases.

  4. Chinese Marine Materia Medica Resources: Status and Potential

    PubMed Central

    Fu, Xiu-Mei; Zhang, Meng-Qi; Shao, Chang-Lun; Li, Guo-Qiang; Bai, Hong; Dai, Gui-Lin; Chen, Qian-Wen; Kong, Wei; Fu, Xian-Jun; Wang, Chang-Yun

    2016-01-01

    Chinese marine materia medica (CMMM) is a vital part of traditional Chinese medicine (TCM). Compared with terrestrial TCM, CMMM, derived from specific marine habitats, possesses peculiar chemical components with unique structures reflecting as potent pharmacological activities, distinct drug properties and functions. Nowadays, CMMM appears to be especially effective in treating such difficult diseases as cancers, diabetes, cardio-cerebrovascular diseases, immunodeficiency diseases and senile dementia, and therefore has become an important medicinal resource for the research and development of new drugs. In recent years, such development has attracted wide attention in the field of medicine. In this study, the CMMM resources in China were systematically investigated and evaluated. It was found that the historic experiences of Chinese people using CMMM have continuously accumulated over a period of more than 3600 years, and that the achievements of the research on modern CMMM are especially outstanding. By June 2015, 725 kinds of CMMMs from Chinese coastal sea areas have been identified and recorded, covering 1552 organisms and minerals. More than 3100 traditional prescriptions containing CMMMs have been imparted and inherited. However, the number of CMMMs is less than the 8188 terrestrial TCMs, from more than 12,100 medicinal terrestrial plants, animals and minerals. In the future, the research and development of CMMM should focus on the channel entries (TCM drug properties), compatibility, effective ingredients, acting mechanisms, drug metabolism and quality standard. This study reveals the high potential of CMMM development. PMID:26950133

  5. Effects of dentin on the antimicrobial properties of endodontic medicaments.

    PubMed

    Haapasalo, Markus; Qian, Wei; Portenier, Isabelle; Waltimo, Tuomas

    2007-08-01

    Successful treatment of apical periodontitis is dependent on the elimination of the infective microflora from the necrotic root canal system. Antimicrobial irrigating solutions and other locally used disinfecting agents and medicaments have a key role in the eradication of the microbes. While most if not all presently used disinfecting agents rapidly kill even the resistant microbes when tested in vitro in a test tube, the effectiveness of the same agents is clearly weaker in the in vivo conditions. Recent studies have given valuable information about the interaction of endodontic disinfecting agents with dentin and other compounds present in the necrotic root canal. As a result of such interactions the antimicrobial effectiveness of several of our key disinfectants may be weakened, or even eliminated under certain circumstances. Different disinfectants show different sensitivity to the action by the various potential inactivators, such as dentin, serum proteins, hydroxyapatite, collagen derived from different sources, and microbial biomass. This review is a summary of our present knowledge of the mostly negative interactions between endodontic disinfecting agents and the various compounds present in the root canal environment.

  6. Home Delivery Medicament Program: access, inactivity and cardiovascular risk 1

    PubMed Central

    Araújo, Roque da Silva; Arcuri, Edna Apparecida Moura; Lopes, Victor Cauê

    2016-01-01

    ABSTRACT Objective: to verify causes of inactivity in the Home Delivery Medicament Program, as referred by users from a Primary Health Care Service in São Paulo, comparing them to the causes registered in the program and analyzing them in the theoretical model Concept of Access to Health. Methods: cross-sectional study, interviewing 111 inactive users; and documentary study in the program records. Results: half of the users did not know the condition of inactivity. Discrepancies were found between the user's and the program's information, observing different levels of agreement: Absence of physician and administrative staff member 0%; Transfer to other service 25%; Death 50%; Option to quit 50%; Address change 57% and Change in therapeutic schedule 80%. The users' feeling of accepting the program was observed. In the health access concept, inactivity can be explained in the information dimension, in the degree of asymmetry between the patient's and the health professional's knowledge, identified through the indicators: education, knowledge and information sources. Conclusions: due to the low education level, the user does not assimilate the information on the steps of the program flowchart, does not return for the assessment that guarantees its continuity. Consequently, (s)he stops receiving the medication and spends a long time without treatment, increasing the cardiovascular risk of hypertensive (92% of the sample), diabetic (44%) and dyslipidemic patients (31%). PMID:27737378

  7. The classification and application of toxic Chinese materia medica.

    PubMed

    Liu, Xinmin; Wang, Qiong; Song, Guangqing; Zhang, Guangping; Ye, Zuguang; Williamson, Elizabeth M

    2014-03-01

    Many important drugs in the Chinese materia medica (CMM) are known to be toxic, and it has long been recognized in classical Chinese medical theory that toxicity can arise directly from the components of a single CMM or may be induced by an interaction between combined CMM. Traditional Chinese Medicine presents a unique set of pharmaceutical theories that include particular methods for processing, combining and decocting, and these techniques contribute to reducing toxicity as well as enhancing efficacy. The current classification of toxic CMM drugs, traditional methods for processing toxic CMM and the prohibited use of certain combinations, is based on traditional experience and ancient texts and monographs, but accumulating evidence increasingly supports their use to eliminate or reduce toxicity. Modern methods are now being used to evaluate the safety of CMM; however, a new system for describing the toxicity of Chinese herbal medicines may need to be established to take into account those herbs whose toxicity is delayed or otherwise hidden, and which have not been incorporated into the traditional classification. This review explains the existing classification and justifies it where appropriate, using experimental results often originally published in Chinese and previously not available outside China.

  8. Chinese Marine Materia Medica Resources: Status and Potential.

    PubMed

    Fu, Xiu-Mei; Zhang, Meng-Qi; Shao, Chang-Lun; Li, Guo-Qiang; Bai, Hong; Dai, Gui-Lin; Chen, Qian-Wen; Kong, Wei; Fu, Xian-Jun; Wang, Chang-Yun

    2016-03-03

    Chinese marine materia medica (CMMM) is a vital part of traditional Chinese medicine (TCM). Compared with terrestrial TCM, CMMM, derived from specific marine habitats, possesses peculiar chemical components with unique structures reflecting as potent pharmacological activities, distinct drug properties and functions. Nowadays, CMMM appears to be especially effective in treating such difficult diseases as cancers, diabetes, cardio-cerebrovascular diseases, immunodeficiency diseases and senile dementia, and therefore has become an important medicinal resource for the research and development of new drugs. In recent years, such development has attracted wide attention in the field of medicine. In this study, the CMMM resources in China were systematically investigated and evaluated. It was found that the historic experiences of Chinese people using CMMM have continuously accumulated over a period of more than 3600 years, and that the achievements of the research on modern CMMM are especially outstanding. By June 2015, 725 kinds of CMMMs from Chinese coastal sea areas have been identified and recorded, covering 1552 organisms and minerals. More than 3100 traditional prescriptions containing CMMMs have been imparted and inherited. However, the number of CMMMs is less than the 8188 terrestrial TCMs, from more than 12,100 medicinal terrestrial plants, animals and minerals. In the future, the research and development of CMMM should focus on the channel entries (TCM drug properties), compatibility, effective ingredients, acting mechanisms, drug metabolism and quality standard. This study reveals the high potential of CMMM development.

  9. Authentication of Chinese Materia Medica decoction dregs, part 1: comparison of morphological and microscopic features of four Chinese Materia Medica before and after decoction.

    PubMed

    Wong, Lailai; Liang, Zhitao; Chen, Hubiao; Zhao, Zhongzhen

    2011-04-01

    Chinese Materia Medica (CMM) decoction dregs are the residues of medicinal materials after decoction. Accurate identification of CMM in decoction dregs will be helpful for exploring the causes of poisoning or other medical incidents arising after the ingestion of CMM decoctions. To determine how decoction affects the characteristics used to authenticate specific CMM, a systematic study was carried out. In this study, two pairs of Materia Medica that are commonly confused-namely, Baizhu (Atractylodis Macrocephalae Rhizoma) and Cangzhu (Atractylodis Rhizoma), Baishao (Paeoniae Alba Radix) and Chishao (Paeoniae Rubra Radix)-were chosen for investigation. Each pair of Materia Medica has similar morphology in appearance, but they have different functions in Chinese clinic. After decoction, with regard to gross morphological characters, the results showed that bark and wood could be easily distinguished. The striation of vessels and fibers became more prominent because of the contraction of parenchymatous cells, but the lignified cells did not. As for the microscopic characteristics, the cells with thickened walls, such as stone cells and fibers, were basically stable. Most of the parenchymatous cells were broken. Crystals of calcium oxalate showed no changes as they were insoluble in water. Starch granules were gelatinized and aggregated in parenchymatous cells. Inulins were substantially reduced in number as they dissolved in water during decoction. According to these changes in morphological and microscopic characteristics after decoction, the dregs of two pairs of Materia Medica could be distinguished.

  10. [Investigation on supplements from Tang Edition (TE) cited in Jia You ben cao (Materia medica of Jia You reign)].

    PubMed

    Yu, Shun

    2004-01-01

    Xin xiu ben cao (Newly Revised Materia Medica), also called Tang ben cao (Materia Medica of the Tang Dynasty) is the first state pharmacopoeia in the world, the original edition of which was lost yet cited by various books. After analyzing the TE in Jia You ben cao (Materia Medica of Jia You Reign) supplemantarily cited by Zhang Yuxi in the Song Dynasty, the author holds that Zhang himself didn't witness Xin xiu ben cao (Newly Revised Materia Medica) and the so-called TE ought to be derived from Shu ben cao (Materia Medica of Sichuan) because both share the same features. Inference can also be drawn that Xin xiu ben cao (Newly Revised Materia Medica) might have been lost at the time when Jia You ben cao (Materia Medica of Jia You Reign) was compiled in the 2nd year of Jia You Reign (A.D.1057). As the TE was not directly extracted from Xin xiu ben cao (Newly Revised Materia Medica), the trustworthiness of the texts allegedly cited from Xin xiu ben cao should be evaluated in many ways and it should be dealt with prudently while recompiling Xin xiu ben cao (Newly Revised Materia Medica).

  11. [History of Actas Dermo-Sifiliográficas, part I: 1909-1959].

    PubMed

    Del Río, E

    2011-11-01

    Actas Dermo-Sifiliográficas was born in May 1909. At first, issues appeared in step with the academic year, but publication began to follow the calendar year in 1957. Volume 18 was skipped in 1926-7 in an effort to correct confusion in the numbering of volumes and pages of earlier issues. October 1928 saw the journal grow from 6 issues per year to 9. Although the Spanish Civil War brought publication to a halt during the 1936-7 academic year, Actas Dermo-Sifiliográficas was one of the first Spanish scientific journals to recover from the conflict. The initial print run of 100 copies was increased to 700 after the war. The content evolved over time: while originally conceived to provide a strict account of sessions of the Spanish Academy of Dermatology and Venereology (AEDV) -originally known as the Spanish Academy of Dermatology and Syphilology- the journal gradually came to include review articles, case reports, a section summarizing the content of international journals, news and various other types of writing. The editorial board and the association's board of directors were one and the same for many years. According to the earliest charter, the editor-in-chief was also the president of the association and the associate editor was the association's vice-president. The subjects of articles provide a faithful portrait of how the specialty has changed. Syphilis, a main concern before the introduction of penicillin in the 1940s, was sidelined afterwards. The appearance of 20th-century pharmaceuticals such as salvarsan, sulfa drugs, thiazides, and corticosteroids were soon reflected in the number of articles describing their use. Certain original contributions by Spanish authors to international dermatology first appeared in Actas Dermo-Sifiliográficas. Examples are Azúa's description of pseudoepithelioma and Covisa and Bejarano's of chancriform pyoderma. Volume 50 (1959), which included accounts of the 50th anniversary of the association and the journal, closed

  12. Association between ACTA1 candidate gene and performance, organs and carcass traits in broilers.

    PubMed

    Venturini, G C; Stafuzza, N B; Cardoso, D F; Baldi, F; Ledur, M C; Peixoto, J O; El Faro, L; Munari, D P

    2015-12-01

    This study investigates the genetic association of the SNP present in the ACTA1 gene with performance traits, organs and carcass of broilers to help marker-assisted selection of a paternal broiler line (TT) from EMBRAPA Swine and Poultry, Brazil. Genetic and phenotypic data of 1,400 broilers for 68 traits related to body performance, organ weights, weight of carcass parts, and yields as a percentage of organs and carcass parts were used. The maximum likelihood method, considering 4 analytical models, was used to analyze the genetic association between the SNP and these important economic traits. The association analysis was performed using a mixed animal model including the random effect of the animal (polygenic), and the fixed effects of sex (2 levels), hatch (5 levels) and SNP (3 levels), besides the random error. The traits significantly associated (P<0.05) with the SNP were analyzed, along with body weight at 42 days of age (BW42), by the restricted maximum likelihood method using the multi-trait animal model to estimate genetic parameters. The analysis included the residual and additive genetic random effects and the sex-hatch fixed effect. The additive effects of the SNP were associated with breast meat (BMY), liver yield (LIVY), body weight at 35 days of age (BW35); drumstick skin (DSW), drumstick (DW) and breast (BW) weights. The heritability estimates for these traits, in addition to BW42, ranged from 0.24±0.06 to 0.45±0.08 for LIVY and BW35, respectively. The genetic correlation ranged from 0.02±0.18 for LIVY and BMY to 0.97±0.01 for BW35 and BW42. Based on the results of this study, it can be concluded that ACTA1 gene is associated with performance traits BW35, LIV and BMY, DW, BW and DW adjusted for body weight at 42 days of age. Therefore, the ACTA1 gene is an important molecular marker that could be used together with others already described to increase the economically important traits in broilers.

  13. Cerebral arteriopathy associated with heterozygous Arg179Cys mutation in the ACTA2 gene: Report in 2 newborn siblings.

    PubMed

    de Grazia, Jose; Delgado, Ignacio; Sanchez-Montanez, Angel; Boronat, Susana; Del Campo, Miguel; Vazquez, Elida

    2017-01-01

    Mutations in the ACTA2 gene lead to a multisystemic smooth muscle dysfunction syndrome that causes vascular disease, congenital mydriasis, and variable presentation of urinary and gastrointestinal problems. The heterozygous Arg179 mutation is associated with a distinctive cerebrovascular phenotype. We report the cases of two newborn siblings with heterozygous ACTA2 Arg179Cys substitution and provide neuroimaging exams that demonstrate the distinctive cerebrovascular phenotype, also associated with variable degree of hypoplasia of the vertebro-basilar circulation as well as hypoxic-ischemic lesions.

  14. Nordisk ophthalmologisk tidsskrift 1889-1892: the Nordic Journal of Ophthalmology - a forerunner of Acta Ophthalmologica.

    PubMed

    Ehlers, Niels

    2012-06-01

    In the second half of the nineteenth century several ophthalmological journals appeared (Germany, England, France, United States). In the northern countries (Denmark, Finland, Norway, Sweden) an initiative lead to 'Nordisk ophthalmologisk Tidsskrift' published in the scandinavian languages in the years 1889-92. The 'driving force' behind the journal was the first professor in Ophthalmology in Copenhagen, Dr. Edmund Hansen Grut. The purpose with this presentation is to give the background for the rise and fall of the journal which was an attempt to promote Nordic Ophthalmology. The authors turned out, however, to be mainly those involved as editors. The journal never gained broad acceptance and it simply stopped in 1892, without any closing remarks. In spite of its short life the journal should be remembered for the very first publication on the arcuate scotoma, the Bjerrum scotoma from 1889. Although shortlived the initiative was not in vain, as can be read in the preface to the very first volume of Acta ophthalmologica.

  15. Citation analysis of Acta Dermatovenerologica Alpina, Pannonica et Adriatica: 1992-2013.

    PubMed

    Oštrbenk, Anja; Poljak, Mario

    2015-01-01

    Acta Dermatovenerologica Alpina, Pannonica et Adriatica is the leading journal in the field of dermatology and sexually transmitted infections in the region. Several important steps were taken during the last 20 years to improve the journal's quality, global visibility, and international impact. Since 1992, 699 bibliographical items have been published, which received 1,360 citations. Web of Science citable items received on average 2.29 citations per item. Importantly, almost half (49.6%) of all citations retrieved to date were received from 2012 onwards. The predicted impact factor was calculated in a way to match official impact factors published annually in Thomson Scientific Journal Citation Reports. Citation analysis shows a substantial increase of the predicted impact factor since 2006, with values above 0.5 since 2007. For the first time in the journal's history, a predicted impact factor value above 1.0 was recorded in 2013.

  16. The effect of endodontic regeneration medicaments on mechanical properties of radicular dentin

    NASA Astrophysics Data System (ADS)

    Yassen, Ghaeth H.

    Endodontic regeneration treatment of necrotic immature teeth has gained popularity in recent years. The approach suggests a biological alternative to induce a continuous root development. In this project, three in vitro experiments were conducted to investigate the effect of three medicaments used in endodontic regeneration on mechanical properties and chemical structure of radicular dentin. In the first experiment, we investigated longitudinally the effect of medicaments on the indentation properties of the root canal surface of immature teeth using a novel BioDent reference point indenter. A significant difference in the majority of indentation parameters between all groups was found after one-week and one-month application of medicaments (p double antibiotic paste (DAP) > control > calcium hydroxide [Ca(OH)2]. The four-week exposure of dentin to TAP and DAP caused 43% and 31% increase in total indentation distance outcome, respectively. In the second experiment, we investigated longitudinally the effect of medicaments on the chemical structure of immature radicular dentin by measuring the phosphate/amide I ratios of dentin using Attenuated Total Reflection Fourier Transform Infrared Spectroscopy. Phosphate/amide I ratios were significantly different between the four groups after one week, two weeks and four week application of medicaments (p untreated dentin > DAP-treated dentin > TAP-treated dentin. In the third experiment, we investigated longitudinally the effect of medicaments on root fracture resistance and microhardness of radicular dentin. For the microhardness, the two-way interaction between group and time was significant (p<0.001). TAP and DAP caused a significant and continuous decrease in dentin microhardness after one and three month application, respectively. The three-month intracanal application of Ca(OH)2 significantly increased the microhardness of root dentin. The time factor had a significant effect on fracture resistance (p<0.001). All

  17. [The research on the edition of Daquanbencao (Complete Collection of Materia Medica)].

    PubMed

    Li, Jian; Zhang, Wei; Zhang, Rui-xian

    2009-07-01

    Zhengleibencao (Classified Materia Medica) had been formed into several kinds of edition systems during its dissemination, among which there was the edition system of Daquanbencao (Complete Collection of Materia Medica). Daquanbencao was originally carved in the Jin dynasty, thereafter it was re-carved in the Yuan, Ming and Qing dynasties so as to form a series of editions such as the edition of Zhenyou in the second year of the Jin dynasty; the edition of the Zongwenshuyuan college in Dade renyan year of the Yuan dynasty; the WANG Qiu's carved edition of Shangyitang hall in the Ming dynasty; the carved edition of Jishanshuyuan, the Jishang mountain college in the Ming dynasty, the reprinted edition of PENG Duan-wu in the Ming dynasty, the supplementary edition of YANG Bi-da in the Qing dynasty;, and the carved edition of KE Feng-shi in the Qing dynasty. Among all the editions, Chongkanjingshizhengleidaquanbencao (Reprinted Classified Daquan Materia Medica from Historical Classics) was the representative one. As a representative of the above editions, the carved edition of WANG took the edition of the Zongwenshuyuan college of the Yuan dynasty as the original edition, but the images picture of materia medica adopted from the edition of Zhenghebencao (Materia Medica of the Zhenghe era).

  18. [Textual research on adulteration of Chinese materia medica in ancient China].

    PubMed

    Xie, Jin; Wang, De-Qun

    2013-09-01

    By investigating the mainstream works of herbal classics of successive ages, it is found that adulteration of Chinese materia medica appeared early in ancient China. The main methods of adulteration was producing fraud medicines in the Northern-Southern Dynasties, fake medicines began to appear in the Tang Dynasty, and status of adulteration of Chinese materia medica ran unchecked since the Ming and Qing Dynasty. By statistics, there were 76 kinds of adulteration varieties before the Republican period. The main varieties were precious drugs, animal drugs and artifacts. Commonly methods used in the process included forging and adulterating, dealing with 11 kinds and 68 kinds respectively. Adulteration probably lead to the result of imposing the changes of the used medicinal parts of Herba Pogostemonis; Radix Aconiti Lateralis prepared by adding salt, Radix Angelica Sinensis processed by wine, and Radix Astragalis seu Hedysaris processed with bee honey. However, the root cause of adulteration in Chinese materia medica was the dissociation of professional physician and pharmacist, resulting in the ignorance of medical practitioners became unable to recognize Chinese materia medica; and the immorality of medicinal merchants. Besides, rating the quality of materia medica based on its producing areas without differentiating the false from the genuine may also contribute to this result passively.

  19. [Hypothesis and application of bimolecular marking methods in Chinese materia medica].

    PubMed

    Huang, Lu-qi; Qian, Dan; Deng, Chao

    2015-01-01

    Based on the current shortage of genuine/false authentication and quality evaluation in the molecular identification, and the weak functional gene research in the establishment of two-dimensional molecular markering methods for Chinese materia medica, the authors proposed a new method, the bimolecular marking methods (BIMM) for Chinese materia medica, combining DNA marker and metabolomics marker, that could simultaneously research the species and quality differences at the molecular level at the present stage. The authors introduced the concept, principle, methods, and technical process of BIMM, and summarized the technical advantages in this paper. Meanwhile, the application of BIMM in the identification of multiple sources of Chinese materia medica, years-identification, different locations, elite germplasm research, discovery of new drugs resources, protection of new varieties was also discussed. As a supplement of two-dimensional molecular markering method for Chinese materia medica, BIMM would not only expand connotation of identification of Chinese materia medica but also provide another effective way for quality evaluating.

  20. A Short History of Medical Informatics in Bosnia and Herzegovina

    PubMed Central

    Masic, Izet

    2014-01-01

    The health informatics profession in Bosnia and Herzegovina has relatively long history. Thirty five years from the introduction of the first automatic manipulation of data, thirty years from the establishment of Society for Medical Informatics BiH, twenty years from the establishment of the Scientific journal “Acta Informatica Medica (Acta Inform Med”, indexed in PubMed, PubMed Central Scopus, Embase, etc.), twenty years on from the establishment of the first Cathedra for Medical Informatics on Biomedical Faculties in Bosnia and Herzegovina, ten years on from the introduction of the method of “Distance learning” in medical curriculum. The author of this article is eager to mark the importance of the above mentioned Anniversaries in the development of Health informatics in Bosnia and Herzegovina and have attempted, very briefly, to present the most significant events and persons with essential roles throughout this period. PMID:24648621

  1. A short history of medical informatics in bosnia and herzegovina.

    PubMed

    Masic, Izet

    2014-02-01

    The health informatics profession in Bosnia and Herzegovina has relatively long history. Thirty five years from the introduction of the first automatic manipulation of data, thirty years from the establishment of Society for Medical Informatics BiH, twenty years from the establishment of the Scientific journal "Acta Informatica Medica (Acta Inform Med", indexed in PubMed, PubMed Central Scopus, Embase, etc.), twenty years on from the establishment of the first Cathedra for Medical Informatics on Biomedical Faculties in Bosnia and Herzegovina, ten years on from the introduction of the method of "Distance learning" in medical curriculum. The author of this article is eager to mark the importance of the above mentioned Anniversaries in the development of Health informatics in Bosnia and Herzegovina and have attempted, very briefly, to present the most significant events and persons with essential roles throughout this period.

  2. [Principles for molecular identification of traditional Chinese materia medica using DNA barcoding].

    PubMed

    Chen, Shi-Lin; Yao, Hui; Han, Jian-Ping; Xin, Tian-Yi; Pang, Xiao-Hui; Shi, Lin-Chun; Luo, Kun; Song, Jing-Yuan; Hou, Dian-Yun; Shi, Shang-Mei; Qian, Zhong-Zhi

    2013-01-01

    Since the research of molecular identification of Chinese Materia Medica (CMM) using DNA barcode is rapidly developing and popularizing, the principle of this method is approved to be listed in the Supplement of the Pharmacopoeia of the People's Republic of China. Based on the study on comprehensive samples, the DNA barcoding systems have been established to identify CMM, i.e. ITS2 as a core barcode and psbA-trnH as a complementary locus for identification of planta medica, and COI as a core barcode and ITS2 as a complementary locus for identification of animal medica. This article introduced the principle of molecular identification of CMM using DNA barcoding and its drafting instructions. Furthermore, its application perspective was discussed.

  3. [The application of metabonomics in modern studies of Chinese materia medica].

    PubMed

    Chen, Hai-Bin; Zhou, Hong-Guang; Yu, Xiao-Yi

    2012-06-01

    Metabonomics, a newly developing subject secondary to genomics, transcriptomics, and proteomics, is an important constituent part of systems biology. It is believed to be the final direction of the systems biology. It can be directly applied to understand the physiological and biochemical states by its "metabolome profile" as a whole. Therefore, it can provide a huge amount of information different from those originating from other "omics". In the modernization of Chinese materia medica research, the application of metabonomics methods and technologies has a broad potential for future development. Especially it is of important theoretical significance and application value in holistic efficacies evaluation, active ingredients studies, and safety research of Chinese materia medica.

  4. Stereochemistry and conformation of skyllamycin, a non-ribosomally synthesized peptide from Streptomyces sp. Acta 2897.

    PubMed

    Schubert, Vivien; Di Meo, Florent; Saaidi, Pierre-Loïc; Bartoschek, Stefan; Fiedler, Hans-Peter; Trouillas, Patrick; Süssmuth, Roderich D

    2014-04-22

    Skyllamycin is a non-ribosomally synthesized cyclic depsipeptide from Streptomyces sp. Acta 2897 that inhibits PDGF-signaling. The peptide scaffold contains an N-terminal cinnamoyl moiety, a β-methylation of aspartic acid, three β-hydroxylated amino acids and one rarely occurring α-hydroxy glycine. With the exception of α-hydroxy glycine, the stereochemistry of the amino acids was assigned by comparison to synthetic reference amino acids applying chiral GC-MS and Marfey-HPLC analysis. The stereochemistry of α-hydroxy glycine, which is unstable under basic and acidic conditions, was determined by conformational analysis, employing a combination of data from NOESY-NMR spectroscopy, simulated annealing and free MD simulations. The simulation procedures were applied for both R- and S-configured α-hydroxy glycine of the skyllamycin structure and compared to the NOESY data. Both methods, simulated annealing and free MD simulations independently support S-configured α-hydroxy glycine thus enabling the assignment of all stereocenters in the structure of skyllamycin and devising the role of two-component flavin dependent monooxygenase (Sky39) as S-selective.

  5. [Poppy, opium and associated objects in the museum of Materia Medica of the Faculty of Pharmacy].

    PubMed

    Debue-Barazer, Christine; Baudouin, Geneviève; Tillequin, François

    2002-01-01

    The collection of the museum of Materia Medica of the Faculty of Pharmacy, consists of some 400 samples, including poppy capsules and opiums of various geographical origins (indigenous, Turkish, Persian, Egyptian, Indian and Chinese) and numerous tools related to the production of these drugs. Most samples were collected during the XIXth and XXth centuries.

  6. Genetic analysis of citron (Citrus medica L.) using simple sequence repeats and single nucleotide polymorphisms

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Citron (Citrus medica L.) is one of the three basic species of the genus Citrus L. that has contributed to the development of many commercial cultivars. We analyzed the genetic diversity of a total of 54 varieties (47 citrons) to understand the relationships within the species. Thirty two varieties ...

  7. [Revision to origin of northern Artemisia argyi in Compendium of Materia Medica (Bencao gangmu)].

    PubMed

    Huang, Lu-qi; Qiu, Le

    2014-12-01

    The origin of northern Artemisia argyi recorded in Compendium of Materia Medica(Bencao gangmu) is Fudao(Chinese characters) in Tangyin county, While there is only Fudao(Chinese characters) instead of Fudao(Chinese characters). Whether indeed Fudao(Chinese characters) is Fudao(Chinese characters)? By reviewing the genuine evolution of A. argyi, doing textual research on Fudao(Chinese characters) and combing with field survey data of national census of Chinese Materia Medica resources, this paper concluded that the word Fudao(Chinese characters) firstly emerged in Figure Canon of Chinese Materia Medica(Bencao tujing) of Susong in Song dynasty and was applied in later generations, but the implication was not clear, then emerged both Tangyin and Fudao(Chinese characters) in Compendium of Materia Medica(Bencao gangmu). The place Fudao(Chinese characters) is one of the graves of Bianque, that existed from Shang and Zhou dynasty and never changed until now, the A. argyi of Tangyin was famous from the grave of Bianque in Fudao(Chinese characters), which could infer that Lishizhen considered Fudao (Chinese characters) was Fudao(Chinese characters) indeed, and the origin of northern A. argyi was Fudao(Chinese characters) in Tangyin county.

  8. New sensor technologies in quality evaluation of Chinese materia medica: 2010-2015.

    PubMed

    Miao, Xiaosu; Cui, Qingyu; Wu, Honghui; Qiao, Yanjiang; Zheng, Yanfei; Wu, Zhisheng

    2017-03-01

    New sensor technologies play an important role in quality evaluation of Chinese materia medica (CMM) and include near-infrared spectroscopy, chemical imaging, electronic nose and electronic tongue. This review on quality evaluation of CMM and the application of the new sensors in this assessment is based on studies from 2010 to 2015, with prospects and opportunities for future research.

  9. [Differences of bi-directional regulative effects between acu-moxibustion and Chinese materia medica interventions].

    PubMed

    Cao, Xin; Yu, Zhi; Xu, Bin

    2012-10-01

    Bi-directional regulation is referred to a balancing effect of both acu-moxibustion and Chinese materia medica interventions when the human body is experiencing a hyperactivity or hypoactivity due to abnormal intrinsic or external factors. In the present paper, the authors analyze their identical and different characteristics from: 1) definition; 2) characters of regulative effects of acu-moxibustion therapy: A) differentiation of meridian and zangfu-organs being the basis of treatment, B) four factors (acupoint-location, body's functional state, acupoint-formula and needle-manipulation techniques) dependant, C) entirety regulation, and D) centrotaxis modulation; 3) characters of Chinese materia medica intervention: including a) correspondence between the drug property and the syndrome being the basis of the regulative effect, b) multi-factors [components (antagonist and agonist), combination, dosages and processing quality of Chinese materia medica, and functional state of the human body] dependant, c) entirety regulation, and d) both centrotaxis and deviation adjustment. In one word, the bi-directional regulation effect is one of the basic characteristics of both acu-moxibustion and Chinese materia medica in clinical practice, but their basis and modes for inducing effects are different.

  10. [Essential procedure and key methods for survey of traditional knowledge related to Chinese materia medica resources].

    PubMed

    Cheng, Gong; Huang, Lu-qi; Xue, Da-yuan; Zhang, Xiao-bo

    2014-12-01

    The survey of traditional knowledge related to Chinese materia medica resources is the important component and one of the innovative aspects of the fourth national survey of the Chinese materia medica resources. China has rich traditional knowledge of traditional Chinese medicine (TCM) and the comprehensive investigation of TCM traditional knowledge aims to promote conservation and sustainable use of Chinese materia medica resources. Building upon the field work of pilot investigations, this paper introduces the essential procedures and key methods for conducting the survey of traditional knowledge related to Chinese materia medica resources. The essential procedures are as follows. First is the preparation phrase. It is important to review all relevant literature and provide training to the survey teams so that they have clear understanding of the concept of traditional knowledge and master key survey methods. Second is the field investigation phrase. When conducting field investigations, survey teams should identify the traditional knowledge holders by using the 'snowball method', record the traditional knowledge after obtaining prior informed concerned from the traditional knowledge holders. Researchers should fill out the survey forms provided by the Technical Specification of the Fourth National Survey of Chinese Materia Medica Resources. Researchers should pay particular attention to the scope of traditional knowledge and the method of inheriting the knowledge, which are the key information for traditional knowledge holders and potential users to reach mutual agreed terms to achieve benefit sharing. Third is the data compilation and analysis phrase. Researchers should try to compile and edit the TCM traditional knowledge in accordance with intellectual property rights requirements so that the information collected through the national survey can serve as the basic data for the TCM traditional knowledge database. The key methods of the survey include regional

  11. [Research progress on standards of commodity classes of Chinese materia medica and discussion on several key problems].

    PubMed

    Yang, Guang; Zeng, Yan; Guo, Lan-Ping; Huang, Lu-Qi; Jin, Yan; Zheng, Yu-Guang; Wang, Yong-Yan

    2014-05-01

    Standards of commodity classes of Chinese materia medica is an important way to solve the "Lemons Problem" of traditional Chinese medicine market. Standards of commodity classes are also helpful to rebuild market mechanisms for "high price for good quality". The previous edition of commodity classes standards of Chinese materia medica was made 30 years ago. It is no longer adapted to the market demand. This article researched progress on standards of commodity classes of Chinese materia medica. It considered that biological activity is a better choice than chemical constituents for standards of commodity classes of Chinese materia medica. It is also considered that the key point to set standards of commodity classes is finding the influencing factors between "good quality" and "bad quality". The article also discussed the range of commodity classes of Chinese materia medica, and how to coordinate standards of pharmacopoeia and commodity classes. According to different demands, diversiform standards can be used in commodity classes of Chinese materia medica, but efficacy is considered the most important index of commodity standard. Decoction pieces can be included in standards of commodity classes of Chinese materia medica. The authors also formulated the standards of commodity classes of Notoginseng Radix as an example, and hope this study can make a positive and promotion effect on traditional Chinese medicine market related research.

  12. Mutations in Smooth Muscle Alpha-Actin (ACTA2) Cause Coronary Artery Disease, Stroke, and Moyamoya Disease, Along with Thoracic Aortic Disease

    PubMed Central

    Guo, Dong-Chuan; Papke, Christina L.; Tran-Fadulu, Van; Regalado, Ellen S.; Avidan, Nili; Johnson, Ralph Jay; Kim, Dong H.; Pannu, Hariyadarshi; Willing, Marcia C.; Sparks, Elizabeth; Pyeritz, Reed E.; Singh, Michael N.; Dalman, Ronald L.; Grotta, James C.; Marian, Ali J.; Boerwinkle, Eric A.; Frazier, Lorraine Q.; LeMaire, Scott A.; Coselli, Joseph S.; Estrera, Anthony L.; Safi, Hazim J.; Veeraraghavan, Sudha; Muzny, Donna M.; Wheeler, David A.; Willerson, James T.; Yu, Robert K.; Shete, Sanjay S.; Scherer, Steven E.; Raman, C.S.; Buja, L. Maximilian; Milewicz, Dianna M.

    2009-01-01

    The vascular smooth muscle cell (SMC)-specific isoform of α-actin (ACTA2) is a major component of the contractile apparatus in SMCs located throughout the arterial system. Heterozygous ACTA2 mutations cause familial thoracic aortic aneurysms and dissections (TAAD), but only half of mutation carriers have aortic disease. Linkage analysis and association studies of individuals in 20 families with ACTA2 mutations indicate that mutation carriers can have a diversity of vascular diseases, including premature onset of coronary artery disease (CAD) and premature ischemic strokes (including Moyamoya disease [MMD]), as well as previously defined TAAD. Sequencing of DNA from patients with nonfamilial TAAD and from premature-onset CAD patients independently identified ACTA2 mutations in these patients and premature onset strokes in family members with ACTA2 mutations. Vascular pathology and analysis of explanted SMCs and myofibroblasts from patients harboring ACTA2 suggested that increased proliferation of SMCs contributed to occlusive diseases. These results indicate that heterozygous ACTA2 mutations predispose patients to a variety of diffuse and diverse vascular diseases, including TAAD, premature CAD, ischemic strokes, and MMD. These data demonstrate that diffuse vascular diseases resulting from either occluded or enlarged arteries can be caused by mutations in a single gene and have direct implications for clinical management and research on familial vascular diseases. PMID:19409525

  13. Antimicrobial and Cytotoxic Activity of Cuminum Cyminum as an Intracanal Medicament Compared to Chlorhexidine Gel

    PubMed Central

    Abbaszadegan, Abbas; Gholami, Ahmad; Ghahramani, Yasamin; Ghareghan, Razieh; Ghareghan, Marzieh; Kazemi, Aboozar; Iraji, Aida; Ghasemi, Younes

    2016-01-01

    Introduction: The aims of this study were i) to define the chemical constituents of Cuminum cyminum (cumin) essential oil, ii) to compare the antimicrobial activity of this oil to that of chlorhexidine (CHX) and co-trimoxazole on planktonic and biofilm forms of bacteria isolated from the teeth with persistent endodontic infection and iii) to compare the cytotoxicity of these medicaments on L929 fibroblasts. Methods and Materials: Three groups of microorganisms [aerobic bacterial mixture, anaerobic bacterial mixture and Enterococcus faecalis (E .faecalis)] were isolated from the teeth with persistent apical periodontitis. Zone of inhibition (ZOI), minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), minimum biofilm inhibitory concentration (MBIC) and time-kill tests were performed to assess the antimicrobial efficacy of the medicaments. Further, a cytocompatibility analysis of the medicaments was performed on L929 fibroblasts. The results obtained from disc diffusion test and mean cell viability values of the experimental medicaments were analyzed using two-way and one-way analysis of variance (ANOVA). Results: Seventeen constituents were recognized in cumin oil (predominantly cumin aldehyde and γ-terpinene). Co-trimoxazole showed the greatest ZOI followed by cumin and CHX. The smallest MIC and MBC belonged to co-trimoxazole followed by cumin and CHX for all groups of bacteria except for E. faecalis for which the MBC of cumin was smaller than co-trimoxazole. The results of time-kill assay revealed that all medicaments totally inhibited the bacterial growth in all groups after 24 h. CHX was the most cytotoxic solution while there were no significant differences between the cytocompatibility of different concentrations of cumin essential oil and co-trimoxazole. Conclusion: Cumin exhibited a strong antimicrobial efficiency against the microbial flora of the teeth with failed endodontic treatments and it was biocompatible for L929 mouse

  14. The effect of different root canal medicaments on the elimination of Enterococcus faecalis ex vivo

    PubMed Central

    Dammaschke, Till; Jung, Nina; Harks, Inga; Schafer, Edgar

    2013-01-01

    Objective: The aim of this study was to evaluate the antimicrobial effect of chlorhexidine gel (CHX-G) 2%, chlorhexidine powder (CHX-P) 1%, povidone-iodine (PVP-I), polyhexanide and camphorated-and-mentholated chlorophenol (ChKM) ex vivo. Materials and Methods: For every medicament group 10 root segments (15 mm long) of extracted human teeth were prepared to ISO-size 45 and sterilized (n = 50). The root segments were then inoculated with Enterococcus faecalis and aerobically incubated at 37°C. After 1 week, ten root canals were filled with one of the medicaments, respectively and aerobically incubated at 37°C for another week. Ten teeth served as positive controls and were filled with sterile saline solution. After 7 days, the medicaments were inactivated and all root canals were instrumented to ISO-size 50. The obtained dentin samples were dispersed in Ringer solution followed by the preparation of serial dilutions. 10 μl per sample were applied to an agar plate and incubated at 37°C for 48 h. The colony forming units were counted and the reduction factors (RFs) were calculated and statistically analyzed. Results: Compared with the positive controls all medicaments exhibited an antibacterial effect against E. faecalis. The RFs for CHX-G, CHX-P and ChKM were significantly higher compared to PVP-I and polyhexanide (P < 0.05). In contrast to PVP-I and polyhexanide, CHX-G, CHX-P and ChKM were able to eliminate E. faecalis from all dentin samples. Conclusions: Within the limitations of this ex vivo investigation, 2% CHX-G and CHX-P were as effective as ChKM against E. faecalis. Thus, when choosing a root canal medicament the better biocompatibility of CHX compared with ChKM should be taken in consideration. PMID:24932119

  15. Effects of different intra canal medicaments on the push out bond strength of endodontic sealers

    PubMed Central

    Shakouie, Sahar; Shahi, Shahriar; Samiei, Mohammad; Milani, Amin-Salem; Reyhani, Mohammad-Frough; Paksefat, Sara; Eskandarinekhad, Mahsa

    2017-01-01

    Background One of the essential properties of the root canal sealers is the adhesion to root canal dentin and their higher bond strength decreases the microleakage. The aim of the present study was to compare the effect of Different Intracanal medicaments on the push out bond strength of AH26 and MTA Fillapex sealers. Material and Methods A total of 104 one-rooted extracted human teeth were divided into 4 (n=26) experimental groups. After the cleaning and shaping, the root canals were filled with Ca(OH)2, triantibiotic paste (TAP), Metapex or 2% chlorhexidine gel for two weeks. Then, intracanal medicaments were rinsed away and the samples in the sub-groups were obturated with gutta-percha and AH26 or MTA Fillapex sealers. After two weeks incubation, 2-mm-thick middle section of each root was then subjected to push-out testing. Data were analyzed with two-way ANOVA and LSD test. Results With all the intracanal medicaments, the overall mean of bond strength values were significantly higher with AH26 compared to MTA Fillapex (p<0.05). With the use of MTA Fillapex the maximum and minimum means of bond strength values were recorded with CHX and Metapex and for AH26 were recorded with Ca(OH)2 and chlorhexidine, respectively. Conclusions The bond strengths of sealers to dentin are under the influence of pre-treatment with intracanal medicaments. Under the limitations of the present study, the effect of TAP on the bond strength of endodontic sealers was not negative. Key words:AH26, medicament, MTA Fillapex, push-out bond. PMID:28298989

  16. [Important application of intestinal transporters and metabolism enzymes on gastrointestinal disposal of active ingredients of Chinese materia medica].

    PubMed

    Bi, Xiaolin; Du, Qiu; Di, Liuqing

    2010-02-01

    Oral drug bioavailability depends on gastrointestinal absorption, intestinal transporters and metabolism enzymes are the important factors in drug gastrointestinal absorption and they can also be induced or inhibited by the active ingredients of Chinese materia medica. This article presents important application of intestinal transporters and metabolism enzymes on gastrointestinal disposal of the active ingredients of Chinese materia medica, and points out the importance of research on transport and metabolism of the active ingredients of Chinese materia medica in Chinese extract and Chinese medicinal formulae.

  17. [Application of bioassay in quality control of Chinese materia medica-taking Radix Isatidis as an example].

    PubMed

    Yan, Dan; Ren, Yongshen; Luo, Jiaoyang; Li, Hanbing; Feng, Xue; Xiao, Xiaohe

    2010-10-01

    Bioassay, which construct the characteristics consistents with Chinese medical science, is the core mode and methods for the quality control of Chinese materia medica. Taking the bioassay of Radix Isatidis as an example, the contribution, status and application of bioassay in the quality control of Chinese materia medica were introduced in this article, and two key issue (the selection of reference and measurement methods) in the process of establishing bioassay were also explained. This article expects to provide a reference for the development and improvement of the bioassay of Chinese materia medica in a practical manipulation level.

  18. Chemical Composition and in Vitro Antimicrobial, Cytotoxic, and Central Nervous System Activities of the Essential Oils of Citrus medica L. cv. 'Liscia' and C. medica cv. 'Rugosa' Cultivated in Southern Italy.

    PubMed

    Aliberti, Luigi; Caputo, Lucia; De Feo, Vincenzo; De Martino, Laura; Nazzaro, Filomena; Souza, Lucéia Fátima

    2016-09-18

    Citrus medica cv. 'liscia' and C. medica cv. 'rugosa' are two taxa of citron, belonging to the biodiversity of South Italy, in particular of Amalfi Coast, in the Campania region. The chemical composition of the essential oils (EOs) from fruit peels of both C. medica cultivars was studied by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) analyses. In all, 100 compounds were identified, 82 for C. medica cv. 'liscia', accounting for 91.4% of the total oil, and 88 for C. medica cv. 'rugosa', accounting for 92.0% of the total oil. Monoterpene hydrocarbons are the main constituents in both oils of C. medica cv. 'liscia' (79.1%) and C. medica cv. 'rugosa' (80.2%). In both oils, limonene (67.2%-62.8%) and camphene (8.5%-10.9%) are the main constituents. The antimicrobial activity of the EOs was assayed against some bacterial strains: Bacillus cereus (DSM 4313), Bacillus cereus (DSM 4384), Staphylococcus aureus (DSM 25693), Pseudomonas aeruginosa (ATCC 50071), and Escherichia coli (DSM 8579). Low concentrations of C. medica cv. 'rugosa' EO showed an inhibitory effect on P. aeruginosa and higher concentrations inhibited more B. cereus (4384) and E. coli than S. aureus. The cytotoxicity of the EO was evaluated against SH-SY5Y cell line. The influence of the EO on the expression of adenylate cyclase 1 (ADCY1) was also studied. The antimicrobial activity registered confirm their traditional uses as food preserving agents and led us to hypothesize the possible use of these oils as antimicrobials. The alterations in ADCY1 expression suggested a role for limonene in effects on the central nervous system.

  19. Antimicrobial Activity of Endodontic Medicaments and Vehicles using Agar Well Diffusion Method on Facultative and Obligate Anaerobes

    PubMed Central

    Bhat, Kishore G; Sogi, Suma

    2016-01-01

    Aims The aim of this study was to determine the relative antimicrobial effectiveness of these endodontic medicaments and various vehicles using an agar well diffusion assay. Materials and methods Double Antibiotic Paste(DAP), modified DAP, 2% Chlorhexidine gluconate and their combination with four vehicles namely Polyethylene glycol 400 (PEG), Propylene glycol (PG), combinations of PG with PEG and lastly Glycerine were tested using agar well diffusion assay. The minimum bactericidal concentration was noted against four standard strains of organisms ie Streptococcus mutans ATCC( American Type Culture Collection) 25175, Staphylococcus aureus ATCC 12598, Enterococcus faecalis ATCC 35550 and Eschericia coli ATCC 25922. Successful endodontic therapy depends upon thorough disinfection of root canals. In some refractory cases, routine endodontic therapy is not sufficient, so intracanal medicaments are used for proper disinfection of canals. Issues of resistance, limited spectrum of activity and lack of antifungal properties, the hunt for the ideal intracanal medicament continues. In this regard, the vehicles used to form the pastes play a supportive role by forming the appropriate consistency for placement and may dramatically influence their chemical characteristics like their solubility and diffusion. Thus, inorder to use safer and equally effective intracanal medicaments, Chlorhexidine gluconate is being unveiled in this study. Results The difference between the four vehicles when combined with the same endodontic medicament studied above is nonsignificant (NS) except against Porphyromonas gingivalis. Propylene glycol is significantly effective than Glycerine when used with DAP ie C+M medicament combination. (p = 0.029) Conclusion 2% chlorhexidine gluconate and modified DAP can definitely replace DAP and triple antibiotic paste as end-odontic medicaments with chlorhexidine having an added advantage of bactericidal action, substantivity, biocompatibility, low toxicity

  20. Vinculin Proteolysis Unmasks an ActA Homolog for Actin-based Shigella Motility

    PubMed Central

    Laine, Roney O.; Zeile, William; Kang, Fan; Purich, Daniel L.; Southwick, Frederick S.

    1997-01-01

    To generate the forces needed for motility, the plasma membranes of nonmuscle cells adopt an activated state that dynamically reorganizes the actin cytoskeleton. By usurping components from focal contacts and the actin cytoskeleton, the intracellular pathogens Shigella flexneri and Listeria monocytogenes use molecular mimicry to create their own actin-based motors. We raised an antibody (designated FS-1) against the FEFPPPPTDE sequence of Listeria ActA, and this antibody: (a) localized at the trailing end of motile intracellular Shigella, (b) inhibited intracellular locomotion upon microinjection of Shigella-infected cells, and (c) cross-reacted with the proteolytically derived 90-kD human vinculin head fragment that contains the Vinc-1 oligoproline sequence, PDFPPPPPDL. Antibody FS-1 reacted only weakly with full-length vinculin, suggesting that the Vinc-1 sequence in full-length vinculin may be masked by its tail region and that this sequence is unmasked by proteolysis. Immunofluoresence staining with a monoclonal antibody against the head region of vinculin (Vin 11-5) localized to the back of motile bacteria (an identical staining pattern observed with the anti-ActA FS-1 antibody), indicating that motile bacteria attract a form of vinculin containing an unmasked Vinc-1 oligoproline sequence. Microinjection of submicromolar concentrations of a synthetic Vinc-1 peptide arrested Shigella intracellular motility, underscoring the functional importance of this sequence. Western blots revealed that Shigella infection induces vinculin proteolysis in PtK2 cells and generates p90 head fragment over the same 1–3 h time frame when intracellular bacteria move within the host cell cytoplasm. We also discovered that microinjected p90, but not full-length vinculin, accelerates rates of pathogen motility by a factor of 3 ± 0.4 in Shigella-infected PtK2 cells. These experiments suggest that vinculin p90 is a rate-limiting component in actin-based Shigella motility, and that

  1. Use study of Excerpta Medica abstract journals: to drop or not to drop?

    PubMed Central

    Alligood, E C; Russo-Martin, E; Peterson, R A

    1983-01-01

    The directors of the Claude Moore Health Sciences Library, a medium-sized library serving the University of Virginia medical and nursing schools, were concerned over the increasing cost of periodical subscriptions and so studied the use of the printed copy of Excerpta Medica. This study had six parts: (1) availability in other campus libraries; (2) staff perceptions of in-library use; (3) results of studies performed by other libraries in the United States; (4) recorded in-library use; (5) users' opinions; and (6) personal interviews with library users and with selected departments tht corresponded with the forty-four subject areas of Excerpta Medica. The user-survey parts (4 and 5) elicited few responses, but personal interviews allowed a good look at levels of use and interest. The overall results convinced staff to drop some sections and publicize those that remained. PMID:6626797

  2. [Data validation methods and discussion on Chinese materia medica resource survey].

    PubMed

    Zhang, Yue; Ma, Wei-Feng; Zhang, Xiao-Bo; Zhu, Shou-Dong; Guo, Lan-Ping; Wang, Xing-Xing

    2013-07-01

    From the beginning of the fourth national survey of the Chinese materia medica resources, there were 22 provinces have conducted pilots. The survey teams have reported immense data, it put forward the very high request to the database system construction. In order to ensure the quality, it is necessary to check and validate the data in database system. Data validation is important methods to ensure the validity, integrity and accuracy of census data. This paper comprehensively introduce the data validation system of the fourth national survey of the Chinese materia medica resources database system, and further improve the design idea and programs of data validation. The purpose of this study is to promote the survey work smoothly.

  3. [Study on early-warning of Chinese materia medica price base on ARMA model].

    PubMed

    Chang, Feng; Mao, Yang-Dui

    2014-05-01

    This study sets up an early-warning system framework of Chinese materia medica price, using price index as early warning indicator to establish black early-warning model, with indicator of price index volatility and limit line of "price principal". The research divides warning degree into 5 parts named negative heavy warning, negative light warning, no warning, positive light warning and positive heavy warning, with 5 corresponding lights to describe the change level of the medicine price. Then make an early-warning empirical research based on Chengdu Chinese materia medica price index from December in 2010 to October in 2013. ARMA model is applied to forecast index and the result of early-warning is analyzed, and finally farmer households, companies, customers and the government are recommended respectively.

  4. Endodontic 'solutions' part 1: a literature review on the use of endodontic lubricants, irrigants and medicaments.

    PubMed

    Good, Melissa; El, Karim Ikhlas A; Hussey, David L

    2012-05-01

    Endodontic lubricants, irrigants and medicaments help prepare and disinfect root canal systems (RCS) but primary and secondary cases involve different microbes and therefore it is unlikely that one protocol will be effective for both case types. Each individual 'solution' or sequence of'solutions' could play a significant role in each case type, but there are no detailed published guidelines in existence. To help inform clinical practice it was decided to undertake a literature review followed by a UK and Republic of Ireland wide audit on current endodontic'solution' usage within dental schools. The literature review was undertaken under the following headings: pre-op oral rinse; file lubricants; root canal irrigants and intracanal medicaments and provides an evidence base for protocol development for both primary and retreatment cases.The audit project and the protocols developed from the findings of both the literature review and audit will be presented in Part 2.

  5. Probing for pH-regulated genes in Sinorhizobium medicae using transcriptional analysis.

    PubMed

    Tiwari, Ravi P; Reeve, Wayne G; Fenner, Beau J; Dilworth, Michael J; Glenn, Andrew R; Howieson, John G

    2004-01-01

    The low pH sensitivity of Sinorhizobium species is one of the major causes of reduced productivity of Medicago species (such as lucerne) sown in acidic soils. To investigate the pH response of an acid-tolerant Sinorhizobium medicae strain, a pool of random promoter fusions to gusA was created using minitransposon insertional mutagenesis. Acid-activated expression was identified in 11 mutants; rhizobial DNA flanking insertions in 10 mutants could be cloned and the DNA sequences obtained were used to interrogate the genome database of Sinorhizobium meliloti strain 1021. Acid activated expression was detected for fixNO, kdpC, lpiA, and phrR and for genes encoding a putative lipoprotein, two ABC-transporter components, a putative DNA ligase and a MPA1-family protein. These findings implicate cytochrome synthesis, potassium ion cycling, lipid biosynthesis and transport processes as key components of pH response in S. medicae.

  6. Effect of intracanal medicaments used in endodontic regeneration procedures on microhardness and chemical structure of dentin

    PubMed Central

    Eckert, George Joseph; Platt, Jeffrey Allen

    2015-01-01

    Objectives This study was performed to investigate the effects of different intracanal medicaments on chemical structure and microhardness of dentin. Materials and Methods Fifty human dentin discs were obtained from intact third molars and randomly assigned into two control groups and three treatment groups. The first control group received no treatment. The second control group (no medicament group) was irrigated with sodium hypochlorite (NaOCl), stored in humid environment for four weeks and then irrigated with ethylenediaminetetraacetic acid (EDTA). The three treatment groups were irrigated with NaOCl, treated for four weeks with either 1 g/mL triple antibiotic paste (TAP), 1 mg/mL methylcellulose-based triple antibiotic paste (DTAP), or calcium hydroxide [Ca(OH)2] and finally irrigated with EDTA. After treatment, one half of each dentin disc was subjected to Vickers microhardness (n = 10 per group) and the other half was used to evaluate the chemical structure (phosphate/amide I ratio) of treated dentin utilizing attenuated total reflection Fourier transform infrared spectroscopy (n = 5 per group). One-way ANOVA followed by Fisher's least significant difference were used for statistical analyses. Results Dentin discs treated with different intracanal medicaments and those treated with NaOCl + EDTA showed significant reduction in microhardness (p < 0.0001) and phosphate/amide I ratio (p < 0.05) compared to no treatment control dentin. Furthermore, dentin discs treated with TAP had significantly lower microhardness (p < 0.0001) and phosphate/amide I ratio (p < 0.0001) compared to all other groups. Conclusions The use of DTAP or Ca(OH)2 medicaments during endodontic regeneration may cause significantly less microhardness reduction and superficial demineralization of dentin compared to the use of TAP. PMID:25984471

  7. [Experta--the first society specializing in scientific evaluation of medicaments].

    PubMed

    Valásková, L

    2007-12-01

    The Experta Company, specializing in scientific evaluation of medicaments, was founded in the city of Brno in 1933. Its main task was to control medicaments and mass-produced medicinal preparations, the so-called specialties, offered for their evaluation by pharmaceutical factories. The specialties were analysed using chemical, pharmacological, pharmaceutical, and biological methods. The analyses took place in the laboratories of the Medical Faculty and the Faculty of Natural Sciences, Masaryk University in Brno, and also at the College of Veterinary Surgeons in Brno. The main aim of Experta was to confirm and openly show that the composition of specialties is safe and that the medicaments could be trusted by doctors once evaluated and marked by an Experta mark. The company also made an attempt to prove that medicaments produced in our homeland are equal to those produced abroad, and hereby to support medical prescriptions of Czechoslovak remedies. All the steps taken by Experta were to contribute to economic cost savings of not only our state and health insurance companies but also to those of the patients themselves. Officially the Experta Company came to an end of its existence in 1948; however, the clouds over it darkened earlier, before the Second World War broke out. Despite the fact that Experta existed for only a relatively short period of time and that it did not implement all its aims, its conception and attempts to create in Czechoslovakia in 1934-1948 an independent controlling institute for medical specialties were remarkable and progressive (especially the emphasis on biological control of specialties).

  8. Materia Socio Medica is Indexed in Pubmed and Archived in PubMed Central.

    PubMed

    Masic, Izet

    2013-01-01

    Materia Socio Medica Journal has been accepted for archiving in PubMed Central from 2011. The journal started in 1993 as offi cial journal of Social Medicine Association of B&H. During last 3 years Mat Soc Med has included in almost all femous on-line databases (except WoS). All issues of Mat Soc Med published in 2012 are now visible on PubMed/PubMed Central.

  9. Analgesic Effect of Odontopaste and a Compound Intracanal Medicament Between Root Canal Therapy Appointments

    PubMed Central

    Eftekhar, Behrooz; Moghimipour, Eskandar; Pourakbar Jahandideh, Pejman; Jalali, Sahar; Mahmoudian, Mahsa

    2013-01-01

    Background Pain experience makes a serious anxiety for both patient and clinician before and after root canal treatment. Pain is a complex psychophysiologic phenomenon. Objectives The aim of this randomized control trial study was to evaluate the analgesic effect of Odontopaste® and a corticosteroid containing compound medicament between root canal therapy appointments. Materials and Methods One hundred and twenty lower first and second mandibular molars with spontaneous pain and sensitivity to percussion were selected and divided into three groups (40 patients per each group). After root canal preparation, patients were entered one of these groups randomly. Root canals in group 1 were dressed with Odontopaste, in group 2 with a compound intracanal medicament, and in group 3 with placebo. Patients determined their pain rate and percussion sensitivity on Heft-parker VAS diagram, before the first appointment and 24 hours and 7 days after that. Results Spontaneous pain and Percussion sensitivity score averages of 24 hours after the first appointment in group 1 and group 2 were less than group 3, which indicates statistically significant difference between these groups. There was no statistically significant difference between these groups after 7 days neither on spontaneous pain nor percussion sensitivity. Conclusions Odontopaste® and compound intracanal medicaments resulted in statistically significant reduction in postoperative pain and percussion sensitivity after 24 hours, but there was no statistically significant difference after 7 days with placebo. PMID:24624209

  10. Book Review: Beitraege zur Astronomiegeschichte, Band 5 (Acta Historica Astronomiae Vol. 15)

    NASA Astrophysics Data System (ADS)

    Duerbeck, H. W.; Dick, W. R.; Hamel, J.

    2002-12-01

    The 15th volume of the Acta Historica Astronomiae is at the same time the fifth collection of essays on the history of astronomy (Beitraege zur Astronomiegeschichte, Band 5), edited by the historians of astronomy W.R. Dick (Potsdam) and J. Hamel (Berlin). Besides a few short notices and book reviews, the book contains 11 major articles, which deal with astronomical topics covering the time from the 16th to the 20th centuries. The first article, on the analysis and interpretation of historical horoscopes as a source of the history of science, is based on the inaugural lecture of its author, Guenther Oestmann. After a general introduction, which deals with the principles of horoscope making, the author discusses the horoscope of Count Heinrich Ranzau (1526-1598), the Danish governor of Schleswig-Holstein, who was a friend of Tycho Brahe. Oestmann shows that the astronomical-mathematical basis of such a horoscope can be reconstructed and interpreted. However, it is hardly possible to gain an insight in the process how the interpretation of a horoscope was done in detail. The second and third articles, by Franz Daxecker, deal with Athanasius Kircher and Christoph Scheiner, two catholic astronomers of the 17th century. Kircher's Organum Mathematicum is a calculating device that can be used in the fields of arithmetic, geometry, chronology, astronomy, astrology and others. The author provides extracts of the description of the Organum taken from a book by Caspar Schott, which deal with chronology and astronomy. A photograph of the Organum indicates that this tool consists of a set of tables glued on wooden or cardboard, but details of its contents and applications remain pretty obscure for the reader - a few elaborated examples would have been helpful. The second paper deals with the life of Christoph Scheiner SJ, the co-discoverer of sunspots (next to Galileo), after leaving Rome in 1633 - the year of the Galileo trial. Scheiner spent his later years in the Austrian and

  11. Identification of Sinorhizobium (Ensifer) medicae based on a specific genomic sequence unveiled by M13-PCR fingerprinting.

    PubMed

    Dourado, Ana Catarina; Alves, Paula I L; Tenreiro, Tania; Ferreira, Eugénio M; Tenreiro, Rogério; Fareleira, Paula; Crespo, M Teresa Barreto

    2009-12-01

    A collection of nodule isolates from Medicago polymorpha obtained from southern and central Portugal was evaluated by M13-PCR fingerprinting and hierarchical cluster analysis. Several genomic clusters were obtained which, by 16S rRNA gene sequencing of selected representatives, were shown to be associated with particular taxonomic groups of rhizobia and other soil bacteria. The method provided a clear separation between rhizobia and co-isolated non-symbiotic soil contaminants. Ten M13-PCR groups were assigned to Sinorhizobium (Ensifer) medicae and included all isolates responsible for the formation of nitrogen-fixing nodules upon re-inoculation of M. polymorpha test-plants. In addition, enterobacterial repetitive intergenic consensus (ERIC)-PCR fingerprinting indicated a high genomic heterogeneity within the major M13- PCR clusters of S. medicae isolates. Based on nucleotide sequence data of an M13-PCR amplicon of ca. 1500 bp, observed only in S. medicae isolates and spanning locus Smed_3707 to Smed_3709 from the pSMED01 plasmid sequence of S. medicae WSM419 genome's sequence, a pair of PCR primers was designed and used for direct PCR amplification of a 1399-bp sequence within this fragment. Additional in silico and in vitro experiments, as well as phylogenetic analysis, confirmed the specificity of this primer combination and therefore the reliability of this approach in the prompt identification of S. medicae isolates and their distinction from other soil bacteria.

  12. ICMJE authorship criteria are not met in a substantial proportion of manuscripts submitted to Biochemia Medica

    PubMed Central

    Šupak-Smolčić, Vesna; Mlinarić, Ana; Antončić, Dragana; Horvat, Martina; Omazić, Jelena; Šimundić, Ana-Maria

    2015-01-01

    Introduction Our aim was to investigate if: (a) authors of Biochemia Medica meet authorship criteria given by International Committee of Medical Journal Editors (ICMJE), (b) authorship violations are more frequent in submissions containing some type of scientific misconduct. Materials and methods Self-reported authorship contributions regarding the three ICMJE criteria were analysed for all submissions to Biochemia Medica (February 2013-April 2015) which were forwarded to peer-review. To test the differences in frequencies we used Chi-squared test. P < 0.05 was considered statistically significant. Results 186 manuscripts were authored by 804 authors. All ICMJE criteria were met by 487/804 (61%) authors. The first and the last author met all the criteria more frequently than those authors in between (P < 0.001). The degree to which ICMJE criteria was met for the first author did not differ between manuscripts authored by only one author and those authored by >1 author (P = 0.859). In 9% of the manuscripts ICMJE criteria were not met by a single author. Authors of the 171/186 manuscripts declared that all persons qualify for authorship but only 49% of them satisfied all ICMJE criteria. Authors have failed to acknowledge contributors in 88/186 (47%) manuscripts; instead these contributors have been listed as authors without fulfilling ICMJE criteria. Authorship violation was not more common in 42 manuscripts with some type of scientific misconduct (P = 0.135). Conclusion Large proportion of authors of the manuscripts submitted to Biochemia Medica do not fulfil ICMJE criteria. Violation of authorship criteria is not more common for manuscripts with some type of scientific misconduct. PMID:26526700

  13. [Preliminary investigation on the materia medica of the Zhuang ethnic group].

    PubMed

    Rong, Xiao-Xiang; Li, Gui

    2013-09-01

    By Zhuang materia medica, it refers to application of medicines under the instructions of medical theory of Zhuang ethnic group. By studying the pronunciation of the Zhuang language for the terms "zhu yu", "bai jiu", and "mi gu" included in the shan hai jing nan shan jing (The Classic of Southern Mountain in Classic of Seas and Mountains) carried out by the Zhuang scholar Qin Bao-lin, it was concluded that the Zhuang minority already applied medicines early in the pre-Qin period. Through extensive cultural communication in different regions in the Wei-Jin-Southern-Northern Dynasties, the medicinal experiences of the Zhuang ethnic group appeared in ancient literature. The antidotes in Zhou hou fang (Handbook of Prescriptions for Emergency), for instance, were mostly coming from the Southern Ridge area. Since the Sui-Tang Dynasties, many materia medica recorded in the herbal works and regional gazetteers, and Annals such as the Guangxi Annals, Gazetteer of Nanning County, and Gazetteer of Liuzhou County, Gazetteer of Binzhou County etc., also carry medicines such as Cinnamom twigs and bark, and mangosteen etc., which are similar to those of the Zhuang medicines. In the Republican period, many manuscripts of Zhuang medicines appeared. After 1949, many institutions of Zhuang medicine were set up successively, including The Nanning Medical Institute, The Medical Institute of Wuzhou, The Medical Institute of Guilin. Systematic researches were also done, with publication of a series of works on Zhuang materia medica. Reformation of part of the prescription forms of Zhuang medicine were also accomplished.

  14. [Current situation of toxicity classification of Chinese materia medica and its research thoughts].

    PubMed

    Sun, Wenyan; Hou, Xiujuan; Wang, Bin; Zhu, Yuelan; Zhang, Shuofeng; Chang, Hongsheng; Sun, Jianning

    2012-08-01

    Toxicity of Chinese materia medica (CMM) is an important part of Chinese herbal nature theory. In clinical application, the dosage, time limitation and compatibility of CMM is mainly determined by toxicity. At present, there is no uniform toxicity classification standard for the evaluation of Chinese herbal toxicity. Therefore, it is significant to research toxicity classification of CMM. The current situation of toxicity classification of CMM is reviewed in this paper, and proposed research thoughts are as follows: the measurement of toxicity parameters, the confirmation of poisoning target organs, the investigation on toxic mechanism by serum pharmacology and toxicokinetics, the comprehensive evaluation on toxicity based on quantitative theory.

  15. [The translation and its meanings of Materia Medica Part. I in the Jejungwon].

    PubMed

    Park, Junhyoung; Park, Hyoungwoo

    2011-12-31

    For more systematic medical education, Dr. O. R. Avison translated medical textbooks into Korean since he took charge of Jejungwon in 1893. The first book he chose was Anatomy of the Human Body. He, however, failed to see it published after losing its manuscript twice. Instead, Materia Medica Part. I was brought into the world first in 1905, for which he translated Materia Medica and Therapeutics written by John Mitchell Bruce from the U. K. At that time, this book was in widespread use in the English-speaking world as a textbook for pharmacology. It is also assumed that Avison used it as a textbook for his classes in Canada before coming to Korea. For the publication of Materia Medica Part. I, Avison did not translate Bruce's original text in full, but translated only the selected passages. He followed a principle of using Korean alphabets (Hangeul) only, but in combination with Chinese characters, if necessary. He put pharmacological terms into existing Korean equivalents or newly coined words, but also borrowed many from Japanese terms. That's because Japan moved faster to introduce Western medicine than Korea did, so that many pharmacological terms could be defined and arranged more systematically in Japanese. Moreover, Japan took such a favorable stance in the state of international affairs that many of Japanese-style terms could be introduced into Korea in most fields including medicine. By translating Materia Medica Part. I in cooperation with his disciple KIM Pilsoon after Gray's Anatomy of the Human Body, Avison tried to lay groundwork for providing medical education in Korea based on the British-American medicine. It is assumed that he took an independent stance in selecting and translating Western medical textbooks on his own rather than simply accepting the existing Chinese translation of Western medical textbooks. Despite all his efforts, he might find it difficult to translate all the Western medical terms into Korean within a short period of time

  16. Excerpta Medica abstracting journals: a case study of costs to medical school libraries.

    PubMed

    La Rocco, A; Feng, C

    1977-04-01

    A cost comparison study was made of Excerpta Medica's abstracting journals, based upon actual costs to a library. Unit costs were determined for six sections of EM as compared with six corresponding abstract journals. On average, EM sections were found to be 138% more costly than corresponding abstract journals. The effects of splitting of EM journal titles were also analyzed. This practice increases the price of a total subscription to EM and makes comprehensive information retrieval more difficult. A survey of medical school librarians as users of EM points to dissatisfaction with its increasing price, particularly when it results from title splitting.

  17. Identification of species and materia medica within Angelica L. (Umbelliferae) based on phylogeny inferred from DNA barcodes

    PubMed Central

    YUAN, QING-JUN; ZHANG, BIN; JIANG, DAN; ZHANG, WEN-JING; LIN, TSAI-YUN; WANG, NIAN-HE; CHIOU, SHU-JIAU; HUANG, LU-QI

    2015-01-01

    DNA barcodes have been increasingly used in authentication of medicinal plants, while their wide application in materia medica is limited in their accuracy due to incomplete sampling of species and absence of identification for materia medica. In this study, 95 leaf accessions of 23 species (including one variety) and materia medica of three Pharmacopoeia-recorded species of Angelica in China were collected to evaluate the effectiveness of four DNA barcodes (rbcL, matK, trnH-psbA and ITS). Our results showed that ITS provided the best discriminatory power by resolving 17 species as monophyletic lineages without shared alleles and exhibited the largest barcoding gap among the four single barcodes. The phylogenetic analysis of ITS showed that Levisticum officinale and Angelica sinensis were sister taxa, which indicates that L. officinale should be considered as a species of Angelica. The combination of ITS + rbcL + matK + trnH-psbA performed slight better discriminatory power than ITS, recovering 23 species without shared alleles and 19 species as monophyletic clades in ML tree. Authentication of materia medica using ITS revealed that the decoction pieces of A. sinensis and A. biserrata were partially adulterated with those of L. officinale, and the temperature around 80 °C processing A. dahurica decoction pieces obviously reduced the efficiency of PCR and sequencing. The examination of two cultivated varieties of A. dahurica from different localities indicated that the four DNA barcodes are inefficient for discriminating geographical authenticity of conspecific materia medica. This study provides an empirical paradigm in identification of medicinal plants and their materia medica using DNA barcodes. PMID:24961287

  18. Identification of species and materia medica within Angelica L. (Umbelliferae) based on phylogeny inferred from DNA barcodes.

    PubMed

    Yuan, Qing-Jun; Zhang, Bin; Jiang, Dan; Zhang, Wen-Jing; Lin, Tsai-Yun; Wang, Nian-He; Chiou, Shu-Jiau; Huang, Lu-Qi

    2015-03-01

    DNA barcodes have been increasingly used in authentication of medicinal plants, while their wide application in materia medica is limited in their accuracy due to incomplete sampling of species and absence of identification for materia medica. In this study, 95 leaf accessions of 23 species (including one variety) and materia medica of three Pharmacopoeia-recorded species of Angelica in China were collected to evaluate the effectiveness of four DNA barcodes (rbcL, matK, trnH-psbA and ITS). Our results showed that ITS provided the best discriminatory power by resolving 17 species as monophyletic lineages without shared alleles and exhibited the largest barcoding gap among the four single barcodes. The phylogenetic analysis of ITS showed that Levisticum officinale and Angelica sinensis were sister taxa, which indicates that L. officinale should be considered as a species of Angelica. The combination of ITS + rbcL + matK + trnH-psbA performed slight better discriminatory power than ITS, recovering 23 species without shared alleles and 19 species as monophyletic clades in ML tree. Authentication of materia medica using ITS revealed that the decoction pieces of A. sinensis and A. biserrata were partially adulterated with those of L. officinale, and the temperature around 80 °C processing A. dahurica decoction pieces obviously reduced the efficiency of PCR and sequencing. The examination of two cultivated varieties of A. dahurica from different localities indicated that the four DNA barcodes are inefficient for discriminating geographical authenticity of conspecific materia medica. This study provides an empirical paradigm in identification of medicinal plants and their materia medica using DNA barcodes.

  19. [Work and health of the Cordoba National University teachers: medicaments/legal drugs use and infantile-maternal plan].

    PubMed

    Giacone, Marta Susana; Costa, Maria Cristina Silva

    2004-01-01

    This study aimed to investigate university teachers in reproductive age--life conditions, work and health process and medicaments use. Beside, aimed research the use, opinions and suggestions of Infantile-Maternal Plan of the University Social Assistance clients. In dialectic and historic materialism theory and method way, this is a social research developed by a strategic and correlative-descriptive fieldwork with 50 persons sample. The results showed degraded work and life conditions, affecting the teachers' health profile and medicaments use. The Infantile-Maternal Plan is good or very good and demands best information accord the teachers in high percent opinion.

  20. Fetal akinesia caused by a novel actin filament aggregate myopathy skeletal muscle actin gene (ACTA1) mutation.

    PubMed

    Stenzel, Werner; Prokop, Stefan; Kress, Wolfram; Huppmann, Stephanie; Loui, Andrea; Sarioglu, Nanette M E; Laing, Nigel G; Sparrow, John C; Heppner, Frank L; Goebel, Hans H

    2010-08-01

    We report a female newborn, diagnosed with fetal akinesia in utero, who died one hour after birth. Post-mortem muscle biopsy demonstrated actin-filament myopathy based on immunolabelling for sarcomeric actin, and large areas of filaments, without rod formation, ultrastructurally. Analysis of DNA extracted from the muscle disclosed a novel de novo heterozygous c.44G>A, GGC>GAC, 'p.Gly15Asp' mutation in the ACTA1 gene. Analysis of the location of the mutated amino-acid in the actin molecule suggests the mutation most likely causes abnormal nucleotide binding, and consequent pathological actin polymerization. This case emphasizes the association of fetal akinesia with actin-filament myopathy.

  1. [Discussion on Tang edition (TE) and notes of the Tang edition (NT) under the "ink cap" in Zheng lei ben cao (Classified materia medica)].

    PubMed

    Shang, Zhijun

    2002-04-01

    The TE and NT cited under ink cap in Zheng lei ben cao (Classified Materia Medica) cannot be found in the contents and fragmentary volumes of Xin xiu ben cao (Newly Revised Materia Medica), yet can be seen in the "annotations of Shu ben cao (Materia Medica of Sichuan)", cited by Zhang Yuxi. This showed that the TE and NT were, in fact, coming from Shu ben cao, whose old name was Chong guang ying gong ben cao (Augmented Yinggong's Materia Medica). The so - called Yinggong was Li Ji, who compiled Tang ben cao (Materia Medica of the Tang Dynasty) by the imperial order, and gained the title Master Yingguogong, hence the title. Chong guang ying gong ben cao was meant revised Tang ben cao. This was the reason why Tang Shenwei called Shu ben cao as Tang ben cao right away in his Zheng lei ben cao.

  2. [Research practices of conversion efficiency of resources utilization model of castoff from Chinese material medica industrialization].

    PubMed

    Duan, Jin-Ao; Su, Shu-Lan; Guo, Sheng; Liu, Pei; Qian, Da-Wei; Jiang, Shu; Zhu, Hua-Xu; Tang, Yu-Ping; Wu, Qi-Nan

    2013-12-01

    The industrialization chains and their products, which were formed from the process of the production of medicinal materials-prepared drug in pieces and deep processed product of Chinese material medica (CMM) resources, have generated large benefits of social and economic. However, The large of herb-medicine castoff of "non-medicinal parts" and "rejected materials" produced inevitably during the process of Chinese medicinal resources produce and process, and the residues, waste water and waste gas were produced during the manufactured and deep processed product of CMM. These lead to the waste of resources and environmental pollution. Our previous researches had proposed the "three utilization strategies" and "three types of resources models" of herb-medicine castoff according to the different physicochemical property of resources constitutes, resources potential and utility value of herb-medicine castoff. This article focus on the conversion efficiency of resources model and analysis the ways, technologies, practices, and application in herb-medicine cast off of the conversion efficiency of resources model based on the recycling economy theory of resources and thoughts of resources chemistry of CMM. These data may be promote and resolve the key problems limited the industrialization of Chinese material medica for long time and promote the realization of herb-medicine castoff resources utilization.

  3. Bacteriological evaluation of Allium sativum oil as a new medicament for pulpotomy of primary teeth

    PubMed Central

    Mohammad, Shukry Gamal; Baroudi, Kusai

    2015-01-01

    Objective: To compare the effects of Allium sativum oil and formocresol on the pulp tissue of the pulpotomized teeth. Materials and Methods: Twenty children were selected for this study. All children had a pair of non-vital primary molars. A sterile paper point was dipped in the root canals prior to the mortal pulpotomy. These paper points were collected in transfer media and immediately transported to the microbiological lab to be investigated microbiologically (for Streptococcus mutans and Lactobacillus acidophilus). Then the procedure of mortal pulpotomy was performed. After 2 weeks, the cotton pellets were removed and sterile paper points were dipped in the root canals for microbiological examination. Then comparison between the count of bacteria before and after treatment was conducted. Statistical analysis was performed using independent t-test and paired t-test at the significance level of α = 0.05. Results: After application of both medicaments, there was a marked decrease in S. mutans and L. acidophilus counts. The difference between the mean of log values of the count before and after the application was highly significant for both medicaments (P < 0.05); however, better results were obtained when A. sativum oil was used. Conclusion: A. sativum oil had more powerful antimicrobial effects than formocresol on the bacteria of the infected root canals. PMID:25992338

  4. Study Comparing the Effectiveness of Chlorhexidine, Calcium Hydroxide and Linezolid Based Medicaments Against Enterococcus Faecalis

    PubMed Central

    Pavaskar, Rajdeep; Chalakkal, Paul; Krishnan, Ramesh; Sirikonda, Saritha; Vasepalli, Madhu; Venkataramana, Pammi

    2014-01-01

    Purpose: This study evaluated the efficacy of 2% chlorhexidine (CX), calcium hydroxide (CH), Vitapex® (VP), linezolid (LZ), a combination of LZ with CH (LC) against Enterococcus faecalis (EF). Study Design: EF strains were mixed with peptone water and the turbidity was adjusted to the McFarland’s turbidity standard tube No: 0.5. The inoculum obtained was used to make lawn cultures on the agar plates. A total of 30 agar plates were prepared, such that each plate had five wells containing the five medicaments. The plates were incubated and evaluated for zones of inhibition after intervals of 24 hours and 72 hours. The results were statistically evaluated by paired t-test, ANOVA and Post-hoc analysis using Tukey’s HSD. Results: The difference between values of the zones of inhibition around various medicaments after 24 hours and 72 hours was found to be statistically significant. A comparison between the five groups after 24 hours or 72 hours showed that each group differed significantly from the rest of the groups. Conclusions: LC had the greatest effectiveness against EF, followed by LZ, CX, VP and CH. PMID:24783147

  5. Coverage of Acta Dermatovenerologica Alpina, Pannonica et Adriatica in Elsevier's CiteScore index: a new tool for measuring the citation impact of academic journals.

    PubMed

    Poljak, Mario

    2017-03-01

    In December 2016, Elsevier launched a new tool that helps measure the citation impact of academic journals, called the CiteScore index. The CiteScore index values for 2015 confirmed the status of Acta Dermatovenerologica Alpina, Pannonica et Adriatica (Acta Dermatovenerol APA) as the leading journal in dermatology and sexually transmitted infections in the region. Sixty-five articles published in Acta Dermatovenerol APA from 2012 to 2014 received a total of 77 citations in 2015, resulting in a CiteScore index value of 1.18 for the journal. More than half of the articles published from 2012 to 2014 received at least one citation in 2015. Acta Dermatovenerol APA performed well in all three categories listed because it is ranked 384th out of 1,549 journals in the category General Medicine (75th percentile), 53rd out of 122 journals in the category Dermatology (56th percentile), and 142nd out of 246 journals in the category Infectious Diseases (42nd percentile).

  6. Streptomyces rochei ACTA1551, an Indigenous Greek Isolate Studied as a Potential Biocontrol Agent against Fusarium oxysporum f.sp. lycopersici

    PubMed Central

    Kanini, Grammatiki S.; Katsifas, Efstathios A.; Savvides, Alexandros L.; Karagouni, Amalia D.

    2013-01-01

    Many studies have shown that several Greek ecosystems inhabit very interesting bacteria with biotechnological properties. Therefore Streptomyces isolates from diverse Greek habitats were selected for their antifungal activity against the common phytopathogenic fungus Fusarium oxysporum. The isolate encoded ACTA1551, member of Streptomyces genus, could strongly suppress the fungal growth when examined in antagonistic bioassays in vitro. The isolate was found phylogenetically relative to Streptomyces rochei after analyzing its 16S rDNA sequence. The influence of different environmental conditions, such as medium composition, temperature, and pH on the expression of the antifungal activity was thoroughly examined. Streptomyces rochei ACTA1551 was able to protect tomato seeds from F. oxysporum infection in vivo while it was shown to promote the growth of tomato plants when the pathogen was absent. In an initial effort towards the elucidation of the biochemical and physiological nature of ACTA1551 antifungal activity, extracts from solid streptomycete cultures under antagonistic or/and not antagonistic conditions were concentrated and fractionated. The metabolites involved in the antagonistic action of the isolate showed to be more than one and produced independently of the presence of the pathogen. The above observations could support the application of Streptomyces rochei ACTA1551 as biocontrol agent against F. oxysporum. PMID:23762841

  7. Authentication of Chinese Materia Medica decoction dregs. Part II: comparison before and after decoction of four Chinese Materia Medica that mainly comprise storage tissue.

    PubMed

    Wong, Lailai; Liang, Zhitao; Chen, Hubiao; Zhao, Zhongzhen

    2012-02-01

    Authentication of Chinese Materia Medica (CMM) decoction dregs is important for ensuring the efficacy and safety of CMM when they are used in decoction. If someone got worse or poisoned after taking a decoction while the formula is appropriate, the authentication of CMM dregs is the effective method to explore the reasons. Therefore, a systematic study on the authentication of CMM dregs was carried out. In this study, two pairs of easily confused CMM dregs, Fenge (Puerariae Thomsonii Radix) and Shanyao (Dioscoreae Rhizoma), Dihuang (Rehmanniae Radix) and Huangjing (Polygonati Rhizoma), which mostly comprise storage tissues, were investigated by comparing the morphological and microscopic characteristics. Fenge and Shanyao contain abundant starch granules. After decoction their dregs were hard, nonstarchy and horn-like. Fully gelatinized starch granules were found in the powder of Fenge dregs while incompletely gelatinized starch granules were occasionally found in the Shanyao dregs. In contrast, Dihuang and Huangjing contain water-soluble sugars. After decoction, their dregs were hard and brittle. Their parenchymatous cells were shrunken and unknown crystals were found under microscope. Hence, the morphological and microscopic characteristics of CMM before and after decoction were different, and different changes in the CMM dregs can be illustrated by the different nature of their ergastic substance. These differences could be used to authenticate CMM dregs.

  8. Evaluation of Fluid Absorbency of Retraction Cords after Immersing in Two Retraction Medicaments – An In-vitro Study

    PubMed Central

    Vishnubhotla, Gautam; Karnati, Rajeev Kumar Reddy; Dasari, Pradeep Prabhu; Thommandru, Mani Victor; Bethu, Mohana Bindu

    2016-01-01

    Introduction Dry retraction cords help to displace the gingiva and also to absorb the gingival crevicular fluid and saliva to maintain a dry field. When used along with medicaments whether these medicaments help to improve the absorption of fluid or affect the fluid absorption by decreasing the efficiency of the retraction cord is unknown. Aim The aim of the study was to know the effect of various medicaments on the fluid absorbency of the retraction cords and also, to know whether the thickness of the retraction cords influences it’s fluid absorbency. Materials and Methods A total of 90 samples of 5cm length retraction cords were taken. Cords were divided into 30 samples for each cord thickness of 0, 1 and 2. Of these 30 samples, 10 samples were used to measure dry weight (Group I), 10 samples were immersed in 15.5% ferric sulfate (Group II) and remaining 10 samples were immersed in 10% aluminium chloride (Group III) for a period of 20 minutes. The excess medicament was removed by blotting paper. Initial weight was recorded. Following this, five cords from each group were immersed in plasma solution and remaining in artificial saliva for 10 minutes. Then these were taken out and measured. The amount of the fluid absorbed was determined by subtracting the weight before fluid immersion (weight after immersion in test medicament) from the weight after fluid immersion (weight after immersion in plasma or artificial saliva). The study was analyzed through one-way ANOVA and Bonferroni post-hoc comparisons for pair wise differences. Results When immersed in medicaments, there is a significant difference in absorption of fluids (artificial saliva and plasma) between the untreated dry cord and cord treated with 15.5% ferric sulfate (p<0.05). But, there was no significant difference in fluid absorption between the dry untreated cord and cord treated with 10% aluminum chloride and between cords treated with 15.5% ferric sulfate and 10% aluminum chloride. Conclusion Ferric

  9. The beginnings of Acta Neurochirurgica and the work of Fritz Loew, chief editor from 1958 - 1997. An historical vignette.

    PubMed

    Reulen, Hans-Jürgen; Collmann, Hartmut

    2012-07-01

    Acta Neurochirurgica was founded in 1950, in the difficult time after World War II, by Mario Milletti (Bologna) and Wolfram Sorgo (Innsbruck), and published by Springer press, Vienna. From the beginning the new journal was conceived as an international journal with an impressive list of outstanding neurosurgeons in the editorial board. Only a few years later the issues appeared at irregular intervals due to individual problems of both editors. Wilhelm Tönnis took the initiative to keep the journal alive, when he asked-in consent with Springer press-his staff member Fritz Loew to continue the editorial work and to assemble a new prestigious editorial board. Loew succeeded with both tasks and remained editor-in-chief for nearly 38 years. Initially, all papers were published in the native languages of the authors: English, French, German, Italian and Spanish. With ongoing time the journal accepted manuscripts in English only. The slow progress of this process exemplifies the slow integration of the European countries. In 1971, at the founding meeting of the European Association of Neurosurgical Societies (EANS) in Prague, Acta Neurochirurgica became the official organ of the EANS. Right from the beginning of Acta Neurochirurgica, Supplement volumes were added. Also, the book series Advances and Technical Standards in Neurosurgery is an offspring of Acta Neurochirurgica. Acta Neurochirurgica has become one of the most important neurosurgical journals worldwide. This historical sketch is based on an interview with Fritz Loew, now 91 years old, to which data from the available literature and the Archives of German Neurosurgery, as well as personal information by several colleagues were added.

  10. Comparison of Endodontic Medicaments on Bond Strength of Fiber Post to Root Dentin Using Resin Cement

    PubMed Central

    Zare Jahromi, Maryam; Barekatain, Mehrdad; Ravanbod, Shirin; Ranjbarian, Parisa; Kousehlar, Sara

    2017-01-01

    Statement of the Problem: Endodontic irrigants and medicaments may affect the bond strength of intracanal posts to root dentin. Purpose: The aim of this study was to compare the effect of calcium hydroxide (Ca(OH)2) and 2% chlorhexidine gel (CHX) on bond strength of fiber post cemented with resin cement to root dentin. Materials and Method: This in vitro experimental study was conducted on 36 mandibular premolars. Canals were prepared using the step back technique. After root canal irrigation, the teeth were divided into three groups of 12. Ca(OH)2 paste and CHX gel were used as intracanal medicaments in the first and second groups respectively. No intracanal medicament was used in the third group (control group). Access cavities were then sealed and the teeth were incubated for one week. The root canals were then filled using gutta percha and AH26 sealer and the teeth were incubated for 72 hours. Tooth crowns were then cut at the level of the cementoenamel junction and intracanal posts were placed. The teeth were mounted in auto-polymerizing acrylic resin, and incubated for one week .They were then sectioned into 1.5mm thick slices from their coronal surface using a fully automated cutting machine, and subjected to push-out test until failure. The load at debonding was recorded and data were analyzed using one-way ANOVA, post-hoc test and t-test. The coronal margin of the root was at the level of the surface of acrylic resin in the mold. Results: The mean bond strength was 4.45 MPa in the Ca(OH)2, 2.45 MPa in the CHX and 2.48 MPa in the control group. The difference in this regard was statistically significant among groups (p= 0.04). The Ca(OH)2 group had significant differences with the CHX and control groups (p= 0.03 and p= 0.02, respectively). The difference between the CHX and control groups was not significant (p= 0.974). Conclusion: Based on the results, Ca(OH)2 increased the bond strength of fiber post to root dentin but 2% CHX had no effect on bond

  11. Efficacy of Various Intracanal Medicaments in Human Primary Teeth with Necrotic Pulp against Candida Biofilms: An in vivo Study

    PubMed Central

    Sreedharan, Sheela; Philomina, Beena; Kannan, VP; Santhakumar, Madhu; Kumar, TV Anupam

    2017-01-01

    Background Candida has been associated with cases of secondary and persistent root canal infections. The purpose of this study was to evaluate and compare the effectiveness of commonly used intracanal medicament against Candida biofilms found in root canals of human primary teeth with necrotic pulp. Materials and methods Pulp canals of 45 single-rooted primary maxillary anterior teeth with pulp necrosis in 34 children were included in the study. They were divided into three groups of 15 samples each - group I: Ca(OH)2 (calcium hydroxide); group II: 1% chlorhexidine gel (CHX); and group III: 1% metronidazole gel. Bacterial count was obtained from each tooth at two different stages: (1) after instrumentation, and (2) after placement of the medication. Statistical analysis using the Statistical Package for the Social Sciences version 10.0 software program (Inc., Chicago, IL, USA) with Wilcoxon signed rank test after grouping the samples was performed. Results Ca(OH)2, 1% CHX gel, and 1% metronidazole gel were ineffective in completely eliminating Candida biofilms from root canal of human primary teeth with necrotic pulp. Conclusion None of the commonly used intracanal medicaments, i.e., Ca(OH)2, 1% CHX gel, and 1% metronidazole gel, was effective in completely eliminating Candida biofilm from root canal of human primary teeth with necrotic pulp. Ineffectiveness of these medicaments against Candida has opened new door of research regarding the use of suitable intracanal medicaments against single and multispecies biofilms. How to cite this article Paikkatt JV, Sreedharan S, Philomina B, Kannan VP, Santhakumar M, Kumar TVA. Efficacy of Various Intracanal Medicaments in Human Primary Teeth with Necrotic Pulp against Candida Biofilms: An in vivo Study. Int J Clin Pediatr Dent 2017;10(1):45-48.

  12. Chemical and biological comparison of the fruit extracts of Citrus wilsonii Tanaka and Citrus medica L.

    PubMed

    Zhao, Pan; Duan, Li; Guo, Long; Dou, Li-Li; Dong, Xin; Zhou, Ping; Li, Ping; Liu, E-Hu

    2015-04-15

    Citri Fructus (CF), the mature fruit of Citrus wilsonii Tanaka (CWT) or Citrus medica L. (CML), is an important citrus by-product with health promoting and nutritive properties. The present study compares the chemical and biological differences of CWT and CML. Thin layer chromatography and high performance liquid chromatography, coupled with quadrupole time-of-flight tandem mass spectrometry techniques, were employed to compare the chemical profiles of CWT and CML. A total of 25 compounds were identified and the results indicated that there were significant differences in chemical composition between the two CF species. The quantitative results obtained by HPLC coupled with diode array detector method demonstrated that naringin was present in the highest amounts in CWT, whilst nomilin was the most dominant constituent in CML. It was also found that CWT had significantly higher free radical-scavenging activity than CML.

  13. An Update on the Management of Endodontic Biofilms Using Root Canal Irrigants and Medicaments

    PubMed Central

    Mohammadi, Zahed; Soltani, Mohammad Karim; Shalavi, Sousan

    2014-01-01

    Microbial biofilm is defined as a sessile multicellular microbial community characterized by cells that are firmly attached to a surface and enmeshed in a self-produced matrix of extracellular polymeric substances. Biofilms play a very important role in pulp and periradicular pathosis. The aim of this article was to review the role of endodontic biofilms and the effects of root canal irrigants, medicaments as well as lasers on biofilms A Medline search was performed on the English articles published from 1982 to 2013 and was limited to papers published in English. The searched keywords were “Biofilms AND endodontics”, “Biofilms AND sodium hypochlorite”, "Biofilms AND chlorhexidine", "Biofilms AND MTAD", "Biofilms AND calcium hydroxide", “Biofilms AND ozone”, “Biofilms AND lasers” and "Biofilms AND nanoparticles". The reference list of each article was manually searched to find other suitable sources of information. PMID:24688576

  14. From Materia Medica to the Pharmacopoeia: Challenges of Writing the History of Drugs in India

    PubMed Central

    2016-01-01

    Abstract Historians of indigenous medicine in colonial India have looked more closely at the changes, reinventions and reformulations of institutions of Ayurveda and Unani than at the cognitive content of the drugs themselves. The few historians who have examined the changing content of indigenous medicines have conceptualised the creation of materia medica of Indian drugs through two tropes: one of circulation (of specific drugs) through epistemological and geographic boundaries and the second, of marginalisation of certain other drugs either through a lack of textual legitimacy or the lack of the newly discovered ‘active principles’ within each drug. While these approaches have been useful, there is a case to be made for understanding the creation of formularies of Indian drugs in 19th and 20th centuries through the prism of medical praxis in India. PMID:27570491

  15. [Feasibility analysis of application of future contract in Chinese materia medica transaction].

    PubMed

    Huang, Luqi; Yang, Guang; Zhang, Ruixian; Ma, Chaoyi

    2011-08-01

    With the rapid development of Chinese economy, the traditional Chinese medicine has been paid more attention worldwide because of its therapeutic effect and the special health care function. The future contract which was born under the modern economic system, by its price discovery function and the circumvention risk function, occupies the main superiority in the commodity exchange. The traditional Chinese medicine, which has a glorious transaction history commodity, whether future contract could be used to carry on the transaction still to lack the scientific examination. This article reviewed traditional Chinese medicine tradition trading mode forms with in the evolution foundation, summarized the Chinese materia medica tradition trading mode characteristic, discussed necessity and feasibility of the future contract as a supplement sale way for traditional Chinese medicine transaction. It also forecasted possible risk of future contract, proposed the preliminary implementation method for traditional Chinese medicine future contract.

  16. PAT: From Western solid dosage forms to Chinese materia medica preparations using NIR-CI.

    PubMed

    Zhou, Luwei; Xu, Manfei; Wu, Zhisheng; Shi, Xinyuan; Qiao, Yanjiang

    2016-01-01

    Near-infrared chemical imaging (NIR-CI) is an emerging technology that combines traditional near-infrared spectroscopy with chemical imaging. Therefore, NIR-CI can extract spectral information from pharmaceutical products and simultaneously visualize the spatial distribution of chemical components. The rapid and non-destructive features of NIR-CI make it an attractive process analytical technology (PAT) for identifying and monitoring critical control parameters during the pharmaceutical manufacturing process. This review mainly focuses on the pharmaceutical applications of NIR-CI in each unit operation during the manufacturing processes, from the Western solid dosage forms to the Chinese materia medica preparations. Finally, future applications of chemical imaging in the pharmaceutical industry are discussed.

  17. [Formulation of technical specification for national survey of Chinese materia medica resources].

    PubMed

    Guo, Lan-Ping; Lu, Jian-Wei; Zhang, Xiao-Bo; Zhao, Run-Huai; Zhang, Ben-Gang; Sun, Li-Ying; Huang, Lu-Qi

    2013-04-01

    According to the process of the technical specification (TS) design for the fourth national survey of the Chinese materia medica resources (CMMR), we analyzed the assignment and objectives of the national survey and pointed out that the differences about CMMR management around China, the distribution of CMMR and their habitat, the economic and technological level, and even enthusiasm and initiative of the staff, etc. are the most difficult points for TS design. And we adopt the principle of combination of the mandatory and flexibility in TS design. We fixed the key points which would affect the quality of national survey first, then proposed the framework of TS which including 3 parts of organization and 11 parts of technique itself. The framework will serve and lead the TS preparation, which will not only provide an action standard to the national survey but will also have a profound influence to the popularization and application of the survey technology of CMMR. [Key words

  18. [Real-time detection of quality of Chinese materia medica: strategy of NIR model evaluation].

    PubMed

    Wu, Zhi-sheng; Shi, Xin-yuan; Xu, Bing; Dai, Xing-xing; Qiao, Yan-jiang

    2015-07-01

    The definition of critical quality attributes of Chinese materia medica ( CMM) was put forward based on the top-level design concept. Nowadays, coupled with the development of rapid analytical science, rapid assessment of critical quality attributes of CMM was firstly carried out, which was the secondary discipline branch of CMM. Taking near infrared (NIR) spectroscopy as an example, which is a rapid analytical technology in pharmaceutical process over the past decade, systematic review is the chemometric parameters in NIR model evaluation. According to the characteristics of complexity of CMM and trace components analysis, a multi-source information fusion strategy of NIR model was developed for assessment of critical quality attributes of CMM. The strategy has provided guideline for NIR reliable analysis in critical quality attributes of CMM.

  19. A unique issue in the standardization of Chinese materia medica: processing.

    PubMed

    Zhao, Zhongzhen; Liang, Zhitao; Chan, Kelvin; Lu, Guanghua; Lee, Eko Lai Mei; Chen, Hubiao; Li, Lin

    2010-12-01

    Processing of Chinese Materia Medica (CMM) is a pharmaceutical technique to fulfill the different requirements of therapy, dispensing and making preparations according to traditional Chinese medicine theory. The aims of processing are to enhance the efficacy and/or reduce the toxicity of crude drugs. Those processed products are named as decoction pieces, which are used in clinics. Therefore, there is a close relationship between processing, safety, and efficacy of Chinese medicines. Some toxicity or side effects are caused by improper processing methods and some are due to improper combination of herbal mixtures. Standardization of processing methods for Chinese herbs is as important as authentication to maintain their quality and ensure their safe use. The objective of this paper is to review the literature covering the current situation and problems of CMM processing as well as recent progress in research in this area. A summary of the most urgent work needed is proposed.

  20. [Key content and formulation of national Chinese materia medica resources survey at county level].

    PubMed

    Lu, Jian-Wei; Zhang, Xiao-Bo; Li, Hai-Tao; Guo, Lan-Ping; Zhao, Run-Huai; Zhang, Ben-Gang; Sun, Li-Ying; Huang, Lu-Qi

    2013-08-01

    According to National Census for Water, National Population Census, National Land and Resources Survey, and work experience of experimental measures for national Chinese materia medica resources(CMMR) survey,the national CMMR survey at the county level is the key point of whole survey, that includes organization and management, field survey, sorting data three key links. Organization and management works of national CMMR survey needs to finish four key contents, there are definite goals and tasks, practicable crew, preparation directory, and security assurance. Field survey works of the national CMMR survey needs to finish five key contents, there are preparation works for field survey, the choice of the key survey area (samples), fill in the questionnaire, video data collection, specimen and other physical collection. Sorting data works of the national CMMR survey needs to finish tree key contents, there are data, specimen and census results.

  1. [Impacts of multicomponent environment on solubility of puerarin in biopharmaceutics classification system of Chinese materia medica].

    PubMed

    Hou, Cheng-Bo; Wang, Guo-Peng; Zhang, Qiang; Yang, Wen-Ning; Lv, Bei-Ran; Wei, Li; Dong, Ling

    2014-12-01

    To illustrate the solubility involved in biopharmaceutics classification system of Chinese materia medica (CMMBCS) , the influences of artificial multicomponent environment on solubility were investigated in this study. Mathematical model was built to describe the variation trend of their influence on the solubility of puerarin. Carried out with progressive levels, single component environment: baicalin, berberine and glycyrrhizic acid; double-component environment: baicalin and glycyrrhizic acid, baicalin and berberine and glycyrrhizic acid and berberine; and treble-component environment: baicalin, berberin, glycyrrhizic acid were used to describe the variation tendency of their influences on the solubility of puerarin, respectively. And then, the mathematical regression equation model was established to characterize the solubility of puerarin under multicomponent environment.

  2. [Academic heritage of Jiu huang ben cao (Materia Medica for Relief of Famines) in Japan].

    PubMed

    He, Huiling; Xiao, Yongzhi

    2014-11-01

    Jiu huang ben cao (Materia Medica for Relief of Famines) was the first monograph on famines herbal in the history of China, which creates a new research field of edible plants. Around the middle and late 17th century, Jiu huang ben cao was spread to Japan and aroused great attention of famous Japanese herbalists. Thus, all versions of different edition systems were circulated in Japan. Later, some famous Japanese scholar ssuccessively quoted texts of Jiu huang ben cao from the Nong zheng quan shu (Whole book on Agricultural Administration) spread in Japan, and block-printed it as an independent work. As a result, Jiu huang ben cao virtually circulated widely in Japan.

  3. From Materia Medica to the Pharmacopoeia: Challenges of Writing the History of Drugs in India.

    PubMed

    Bhattacharya, Nandini

    2016-04-01

    Historians of indigenous medicine in colonial India have looked more closely at the changes, reinventions and reformulations of institutions of Ayurveda and Unani than at the cognitive content of the drugs themselves. The few historians who have examined the changing content of indigenous medicines have conceptualised the creation of materia medica of Indian drugs through two tropes: one of circulation (of specific drugs) through epistemological and geographic boundaries and the second, of marginalisation of certain other drugs either through a lack of textual legitimacy or the lack of the newly discovered 'active principles' within each drug. While these approaches have been useful, there is a case to be made for understanding the creation of formularies of Indian drugs in 19th and 20th centuries through the prism of medical praxis in India.

  4. Alshamel fi Sana’at Tebbi’at: A Comprehensive Book on the Materia Medica

    PubMed Central

    Mosaffa-Jahromi, Maryam; Kiani, Hossein

    2016-01-01

    Background: Ala-al-din abu Al-Hassan Ali ibn Abi-Hazm al-Qarshi al-Dimashqi, known as Ibn al-Nafis (1210-1288 AD), was a Muslim Syrian physician primarily famous for being the first to describe the pulmonary circulation of the blood. The most voluminous of his books is Alshamel fi Sana’at tebbi’at, which is a comprehensive medical encyclopedia. It comprised 300 volumes of notes, from which only 80 volumes are published. His writings are cataloged in many libraries around the world. The aim of this review article, as a tribute to Ibn al-Nafis, was to introduce his valuable but neglected encyclopedia of Materia Medica. Methods: Ibn al-Nafis’ traditional approach in his “Alshamel fi Sana’at tebbi’at” book is studied in the present article. Results: Alshamel fi Sana’at tebbi’at covers three branches of knowledge. The first category is devoted to theoretical traditional medicine. The second is in four sections where much of it is not available yet. The third category is on Materia Medica covering the aspect of Unani medicine, from which only 28 volumes of the comprehensive book on the traditional medicine have been found so far. The latter, introduces mono-ingredient medications in alphabetical order. Each chapter, in several parts, is dedicated to the botanical characteristics and nature of each mono-ingredient medication. In addition, this book explains traditional pharmacokinetic of every single medication for each human body organs. Conclusion: Based on pharmaco-mechanistic perspective on Alshamel fi Sana’at tebbi’at, it could be considered as the main reference book on traditional medicine and pharmacy, worthy of revival. PMID:27840486

  5. Studies of beneficial interactions between active medicaments and excipients in pharmaceutical formulations.

    PubMed

    Kalinkova, G N

    1999-09-30

    A review of "up to date" research findings leading to new concepts of the pharmaceutical formulations and their interactions has been presented. The rational approaches to the excipients choice as well as to their interactions with medicaments have been shown as a basis for modern modelling of pharmaceutical formulations. The importance of complexation, hydrogen bonding, ion-dipole, dipole-dipole and van der Waals attractions as the tools which can modify the physicochemical, pharmacological or pharmacokinetical behaviour of the medicaments has been emphasised. In vivo studies (carried out in healthy human subjects-volunteers, in beagle dogs, in rats etc.) and in vitro studies (on excised human skin, hairless mouse skin etc.) as well as studies of chemical stability and bioavailability serve also as a proof of these interactions. Therefore, excipients are important components of pharmaceutical formulations and they can take an active part in the improvement of the characteristics of formulations (but they may also reduce the effectiveness of some preparations). In this context, the so called active and inactive ingredients in pharmaceutical formulations are inexact, old and "out-of date". Their further use is only conventional. In conclusion, among the various modern techniques applied the combination of infrared spectroscopy and X-ray diffraction has been estimated as the most successful in proving the interactions between drugs and excipients. Finally, pharmaceutical formulations and their interactions have constituted a diverse and rapidly expanding field of Pharmacy (Pharmaceutical Technology, Pharmaceutical Industry and Pharmaceutical Sciences) which covers a wide range of numerical topics within an unified framework.

  6. Population genomics of the facultatively mutualistic bacteria Sinorhizobium meliloti and S. medicae.

    PubMed

    Epstein, Brendan; Branca, Antoine; Mudge, Joann; Bharti, Arvind K; Briskine, Roman; Farmer, Andrew D; Sugawara, Masayuki; Young, Nevin D; Sadowsky, Michael J; Tiffin, Peter

    2012-01-01

    The symbiosis between rhizobial bacteria and legume plants has served as a model for investigating the genetics of nitrogen fixation and the evolution of facultative mutualism. We used deep sequence coverage (>100×) to characterize genomic diversity at the nucleotide level among 12 Sinorhizobium medicae and 32 S. meliloti strains. Although these species are closely related and share host plants, based on the ratio of shared polymorphisms to fixed differences we found that horizontal gene transfer (HGT) between these species was confined almost exclusively to plasmid genes. Three multi-genic regions that show the strongest evidence of HGT harbor genes directly involved in establishing or maintaining the mutualism with host plants. In both species, nucleotide diversity is 1.5-2.5 times greater on the plasmids than chromosomes. Interestingly, nucleotide diversity in S. meliloti but not S. medicae is highly structured along the chromosome - with mean diversity (θ(π)) on one half of the chromosome five times greater than mean diversity on the other half. Based on the ratio of plasmid to chromosome diversity, this appears to be due to severely reduced diversity on the chromosome half with less diversity, which is consistent with extensive hitchhiking along with a selective sweep. Frequency-spectrum based tests identified 82 genes with a signature of adaptive evolution in one species or another but none of the genes were identified in both species. Based upon available functional information, several genes identified as targets of selection are likely to alter the symbiosis with the host plant, making them attractive targets for further functional characterization.

  7. Population Genomics of the Facultatively Mutualistic Bacteria Sinorhizobium meliloti and S. medicae

    PubMed Central

    Epstein, Brendan; Branca, Antoine; Mudge, Joann; Bharti, Arvind K.; Briskine, Roman; Farmer, Andrew D.; Sugawara, Masayuki; Young, Nevin D.; Sadowsky, Michael J.; Tiffin, Peter

    2012-01-01

    The symbiosis between rhizobial bacteria and legume plants has served as a model for investigating the genetics of nitrogen fixation and the evolution of facultative mutualism. We used deep sequence coverage (>100×) to characterize genomic diversity at the nucleotide level among 12 Sinorhizobium medicae and 32 S. meliloti strains. Although these species are closely related and share host plants, based on the ratio of shared polymorphisms to fixed differences we found that horizontal gene transfer (HGT) between these species was confined almost exclusively to plasmid genes. Three multi-genic regions that show the strongest evidence of HGT harbor genes directly involved in establishing or maintaining the mutualism with host plants. In both species, nucleotide diversity is 1.5–2.5 times greater on the plasmids than chromosomes. Interestingly, nucleotide diversity in S. meliloti but not S. medicae is highly structured along the chromosome – with mean diversity (θπ) on one half of the chromosome five times greater than mean diversity on the other half. Based on the ratio of plasmid to chromosome diversity, this appears to be due to severely reduced diversity on the chromosome half with less diversity, which is consistent with extensive hitchhiking along with a selective sweep. Frequency-spectrum based tests identified 82 genes with a signature of adaptive evolution in one species or another but none of the genes were identified in both species. Based upon available functional information, several genes identified as targets of selection are likely to alter the symbiosis with the host plant, making them attractive targets for further functional characterization. PMID:22876202

  8. [Investigation on pattern of quality control for Chinese materia medica based on famous-region drug and bioassay--the work reference].

    PubMed

    Yan, Dan; Xiao, Xiaohe

    2011-05-01

    Selection and standardization of the work reference are the technical issues to be faced with in the bioassay of Chinese materia medica. Taking the bioassay of Coptis chinensis. as an example, the manufacture process of the famous-region drugs extraction was explained from the aspects of original identification, routine examination, component analysis and bioassay. The common technologies were extracted, and the selection and standardization procedures of the work reference for the bioassay of Chinese materia medica were drawn up, so as to provide technical support for constructing a new mode and method of the quality control of Chinese materia medica based on the famous-region drugs and bioassay.

  9. Genetic subtyping of Listeria monocytogenes via multiple-locus sequence typing using iap, sigB and actA

    PubMed Central

    YOSHIKAWA, Yuko; OCHIAI, Yoshitsugu; MOCHIZUKI, Mariko; FUJITA, Osamu; TAKANO, Takashi; HONDO, Ryo; UEDA, Fukiko

    2016-01-01

    Pulse field gel electrophoresis (PFGE) is widely used for listeriosis surveillance. Although this technique is effective for epidemiology, the data among laboratories are inconsistent. We previously reported a method for Listeria monocytogenes subtyping combined with sequence analysis of partial iap and whole genome restriction fragment length polymorphism (RFLP) using XbaI, ClaI (BanIII) and PstI. However, distinguishing subtypes was challenging, because the output comprised complicated fragment patterns. In this study, we aimed to establish a simple genotyping method that does not depend on visual observation, rather it focuses on multi-locus sequence typing (MLST) using three genes, iap, sigB and actA. Sixty-eight strains of L. monocytogenes including EGD-e as a reference strain were investigated to ensure consistency with previous data on the genetic characterization. All strains were grouped into 29 types by both analyses. Although there are some differences in classification, major clades included the same strains. Simpson’s indices of diversity (SID) by MLST and iap-RFLP-based typing were 0.967 (95% confidence interval [CI]: 0.955/0.978) and 0.967 (95% CI: 0.955/0.979), respectively. The discriminatory power of both methods can be considered almost identical. Compared with the results of 38 selected strains, the strains within the MLST clusters in this study coincided with those obtained using PFGE. Thus, the MLST strategy could help differentiate among L. monocytogenes isolates during epidemiological studies. PMID:27725353

  10. Comment on “Chen et al., Fabrication and photovoltaic conversion enhancement…”, Electrochimica Acta, 2014

    NASA Astrophysics Data System (ADS)

    Valentic, Lara; Gorji, Nima E.

    2015-09-01

    In a recent article, Chen et al. [Electrochimica Acta, 2014, 130: 279] presented their fabrication and characterization results on a graphene/n-Si solar cell where the Au nanoparticles were inserted in graphene to increase its optical and electrical properties. The higher efficiency of the device was attributed to increased conductivity of graphene after doping with Au nanoparticles. However, the knowledge in the field of Schottky diode solar cells relates this to increased band bending at the junction. Also, to explain the instability behaviour, they concluded that the growth of silicon oxide on the Si surface or oxygen adsorption on the window layer resulted in the device performance increasing initially and decreasing in the end. However, this instability seems to be due to variation in series resistance reduced at the beginning because of slightly lowered Fermi level and increased at the end by the self-compensation by deep in-diffusion of Au nanoparticles into n-Si layer. We also propose that inserting a very thin p-type layer at the junction will enhance the carrier collection and performance of this device.

  11. [Applications and approved projectsof general program, young scientist fund and fund for less developedregion of national natural science funds in discipline of Chinese materia medica, NSFC in 2012].

    PubMed

    Huang, Ming-Qing; Han, Li-Wei; Wu, Xiu-Hong; Bi, Ming-Gang; Shang, Hong-Cai; Liu, Yun-Fang; He, Wei-Ming; Li, Dan-Dan; Dong, Yan; Wang, Chang-En

    2013-01-01

    The applications accepted and approved by general program, young scientist fund and fund for less developed region of national natural science funds in the discipline of Chinese materia medica, NSFC in 2012 have been introduced. The research contents of the funded projects in the popular research areas have been summarized and the problems in the applications have been analyzed to give a reference to the scientists in the field of Chinese materia medica.

  12. Volatile and Flavonoid Composition of the Peel of Citrus medica L. var. Corsican Fruit for Quality Assessment of Its Liqueur.

    PubMed

    Venturini, Nicolas; Barboni, Toussaint; Curk, Franck; Costa, Jean; Paolini, Julien

    2014-12-01

    The volatile and flavonoid compositions of the peel of Citrus medica L. var. Corsican fruits cultivated in Corsica were studied according to the maturity of the citron fruits measured using growing degree-days. Quantitative variation with the stage of development of the fruit was observed using gas chromatography, gas chromatography-mass spectrometry, and liquid chromatography-mass spectrometry/mass spectrometry. Thirty volatile compounds were identified in the peel essential oil. Limonene and γ-terpinene were the major compounds. The volatile compositions of commercial citron liqueurs were also characterized by high amounts of monoterpene hydrocarbons with the same two major components. The main flavonoid components of citron fruits and derived liqueurs were rutin and neohesperidin. This chemical characterization can be used for quality assessment of food products from C. medica var. Corsican.

  13. Genome sequence of Ensifer medicae strain WSM1369; an effective microsymbiont of the annual legume Medicago sphaerocarpos.

    PubMed

    Terpolilli, Jason; Garau, Giovanni; Hill, Yvette; Tian, Rui; Howieson, John; Bräu, Lambert; Goodwin, Lynne; Han, James; Liolios, Konstantinos; Huntemann, Marcel; Pati, Amrita; Woyke, Tanja; Mavromatis, Konstantinos; Markowitz, Victor; Ivanova, Natalia; Kyrpides, Nikos; Reeve, Wayne

    2013-12-20

    Ensifer medicae WSM1369 is an aerobic, motile, Gram-negative, non-spore-forming rod that can exist as a soil saprophyte or as a legume microsymbiont of Medicago. WSM1369 was isolated in 1993 from a nodule recovered from the roots of Medicago sphaerocarpos growing at San Pietro di Rudas, near Aggius in Sardinia (Italy). WSM1369 is an effective microsymbiont of the annual forage legumes M. polymorpha and M. sphaerocarpos. Here we describe the features of E. medicae WSM1369, together with genome sequence information and its annotation. The 6,402,557 bp standard draft genome is arranged into 307 scaffolds of 307 contigs containing 6,656 protein-coding genes and 79 RNA-only encoding genes. This rhizobial genome is one of 100 sequenced as part of the DOE Joint Genome Institute 2010 Genomic Encyclopedia for Bacteria and Archaea-Root Nodule Bacteria (GEBA-RNB) project.

  14. Genome sequence of Ensifer medicae strain WSM1369; an effective microsymbiont of the annual legume Medicago sphaerocarpos

    PubMed Central

    Terpolilli, Jason; Garau, Giovanni; Hill, Yvette; Tian, Rui; Howieson, John; Bräu, Lambert; Goodwin, Lynne; Han, James; Liolios, Konstantinos; Huntemann, Marcel; Pati, Amrita; Woyke, Tanja; Mavromatis, Konstantinos; Markowitz, Victor; Ivanova, Natalia; Kyrpides, Nikos; Reeve, Wayne

    2013-01-01

    Ensifer medicae WSM1369 is an aerobic, motile, Gram-negative, non-spore-forming rod that can exist as a soil saprophyte or as a legume microsymbiont of Medicago. WSM1369 was isolated in 1993 from a nodule recovered from the roots of Medicago sphaerocarpos growing at San Pietro di Rudas, near Aggius in Sardinia (Italy). WSM1369 is an effective microsymbiont of the annual forage legumes M. polymorpha and M. sphaerocarpos. Here we describe the features of E. medicae WSM1369, together with genome sequence information and its annotation. The 6,402,557 bp standard draft genome is arranged into 307 scaffolds of 307 contigs containing 6,656 protein-coding genes and 79 RNA-only encoding genes. This rhizobial genome is one of 100 sequenced as part of the DOE Joint Genome Institute 2010 Genomic Encyclopedia for Bacteria and Archaea-Root Nodule Bacteria (GEBA-RNB) project. PMID:24976897

  15. Biochemia Medica has started using the CrossCheck plagiarism detection software powered by iThenticate.

    PubMed

    Supak-Smolcić, Vesna; Simundić, Ana-Maria

    2013-01-01

    In February 2013, Biodhemia Medica has joined CrossRef, which enabled us to implement CrossCheck plagiarism detection service. Therefore, all manuscript submitted to Biodchemia Medica are now first assigned to Research integrity editor (RIE), before sending the manuscript for peer-review. RIE submits the text to CrossCheck analysis and is responsible for reviewing the results of the text similarity analysis. Based on the CrossCheck analysis results, RIE subsequently provides a recommendation to the Editor-in-chief (EIC) on whether the manuscript should be forwarded to peer-review, corrected for suspected parts prior to peer-review or immediately rejected. Final decision on the manuscript is, however, with the EIC. We hope that our new policy and manuscript processing algorithm will help us to further increase the overall quality of our Journal.

  16. Biochemia Medica has started using the CrossCheck plagiarism detection software powered by iThenticate

    PubMed Central

    Šupak-Smolčić, Vesna; Šimundić, Ana-Maria

    2013-01-01

    In February 2013, Biochemia Medica has joined CrossRef, which enabled us to implement CrossCheck plagiarism detection service. Therefore, all manuscript submitted to Biochemia Medica are now first assigned to Research integrity editor (RIE), before sending the manuscript for peer-review. RIE submits the text to CrossCheck analysis and is responsible for reviewing the results of the text similarity analysis. Based on the CrossCheck analysis results, RIE subsequently provides a recommendation to the Editor-in-chief (EIC) on whether the manuscript should be forwarded to peer-review, corrected for suspected parts prior to peer-review or immediately rejected. Final decision on the manuscript is, however, with the EIC. We hope that our new policy and manuscript processing algorithm will help us to further increase the overall quality of our Journal. PMID:23894858

  17. [Research on Zhang's collated edition of Lei gong pao zhi lun (Master Lei's Discourse on Processing of Chinese Materia Medica)].

    PubMed

    Cheng, Li

    2010-05-01

    Lei gong pao zhi lun (Master Lei's Discourse on Processing of Chinese Materia Medica) collated by Zhang Ji, and printed by Zhang's Yisheng Tang in Chengdu in 1932 was the first collated edition. Its original edition was not Jing shi zheng lei bei ji ben cao (Classified Materia Medica from Historical Classics for Emergency) of the Song Dynasty, but was Xiu shi zhi nan (Instruction for Drug Processing) and Lei gong pao zhi yao xing jie (Explanation on Master Lei's Properties of Drugs Processing) of the Qing Dynasty. The contents of this collated edition was far from Lei gong pao zhi lun with many mistakes, and was not the best edition to study Lei gong pao zhi lun.

  18. [Textual research on Costus root (Aucklandia lappa Decne) in the Sheng nong ben cao jing (Shennong's Classic of Materia Medica)].

    PubMed

    Li, Guangyan; Wang, Dequn; Fang, Shiying; Xu, Maohong

    2014-05-01

    Aucklandia lappa Decne was first recorded in the Sheng nong ben cao jing (Shennong's Classic of Materia Medica). Through the textual research of herbal literature, it was found that the costus root in the Sheng nong ben cao jing perhaps was not the plant of Aucklandia lappa Decne of Compositae, but the eaglewood or Lignum Aquilasria Resinatum based on the comprehensive judgment of shape, taste, nature, and function etc. In the Sheng nong ben cao jing, it only includes costus root without the title of eaglewood, and Tao Hongjing recorded both herbs together in his Ming yi bie lu (Supplementary Records of Celebrated Physicians), which became a foreshadow of misunderstanding of the later generations. Beginning from the Tang ben cao (Materia Medica of the Tang Dynasty), the costus root was considered as the plant of Auckiandia lappa Decne from the Compostae with its profound influence until now.

  19. Volatile and Flavonoid Composition of the Peel of Citrus medica L. var. Corsican Fruit for Quality Assessment of Its Liqueur

    PubMed Central

    Venturini, Nicolas; Barboni, Toussaint; Curk, Franck; Costa, Jean

    2014-01-01

    Summary The volatile and flavonoid compositions of the peel of Citrus medica L. var. Corsican fruits cultivated in Corsica were studied according to the maturity of the citron fruits measured using growing degree-days. Quantitative variation with the stage of development of the fruit was observed using gas chromatography, gas chromatography-mass spectrometry, and liquid chromatography-mass spectrometry/mass spectrometry. Thirty volatile compounds were identified in the peel essential oil. Limonene and γ-terpinene were the major compounds. The volatile compositions of commercial citron liqueurs were also characterized by high amounts of monoterpene hydrocarbons with the same two major components. The main flavonoid components of citron fruits and derived liqueurs were rutin and neohesperidin. This chemical characterization can be used for quality assessment of food products from C. medica var. Corsican. PMID:27904313

  20. Vascular disease-causing mutation R258C in ACTA2 disrupts actin dynamics and interaction with myosin

    PubMed Central

    Lu, Hailong; Fagnant, Patricia M.; Bookwalter, Carol S.; Joel, Peteranne; Trybus, Kathleen M.

    2015-01-01

    Point mutations in vascular smooth muscle α-actin (SM α-actin), encoded by the gene ACTA2, are the most prevalent cause of familial thoracic aortic aneurysms and dissections (TAAD). Here, we provide the first molecular characterization, to our knowledge, of the effect of the R258C mutation in SM α-actin, expressed with the baculovirus system. Smooth muscles are unique in that force generation requires both interaction of stable actin filaments with myosin and polymerization of actin in the subcortical region. Both aspects of R258C function therefore need investigation. Total internal reflection fluorescence (TIRF) microscopy was used to quantify the growth of single actin filaments as a function of time. R258C filaments are less stable than WT and more susceptible to severing by cofilin. Smooth muscle tropomyosin offers little protection from cofilin cleavage, unlike its effect on WT actin. Unexpectedly, profilin binds tighter to the R258C monomer, which will increase the pool of globular actin (G-actin). In an in vitro motility assay, smooth muscle myosin moves R258C filaments more slowly than WT, and the slowing is exacerbated by smooth muscle tropomyosin. Under loaded conditions, small ensembles of myosin are unable to produce force on R258C actin-tropomyosin filaments, suggesting that tropomyosin occupies an inhibitory position on actin. Many of the observed defects cannot be explained by a direct interaction with the mutated residue, and thus the mutation allosterically affects multiple regions of the monomer. Our results align with the hypothesis that defective contractile function contributes to the pathogenesis of TAAD. PMID:26153420

  1. Acta Armamentarii (Selected Articles),

    DTIC Science & Technology

    1982-12-01

    method is not appropriate in engineering technology. In 1968, A.N. Krayko, V.K. Starkov and L.Ye. Sternin (2] used the supposition of the one-dimensional...Equation (23) is written as the general form ~- G GA_ * dx -~& AA 4 .) 2 1W G,, +2’, 4 XpACP rym In the Equation 10 2vv, p2K-! PVV.-i-UtV’n,, +V j K Yay...Lag Loss", Marble, F.E. AIAA J., Vol. 1, No. 12, 1963. 14 [2] A.N. Krayko, L.E. Sternin, V.K. Starkov , "bo±urion or one- dimensional approximation of a

  2. Acta Aerodynamica Sinica,

    DTIC Science & Technology

    1986-11-03

    r &t ar + rx Re -1 ar r ((vur) + 3t) O a~ p ~~ (u 4) r aX 2 -T...radius of curvature of the surface and R is the gas constant. For the dust (a,u , r ) +t--(,ur. (a,u,/h) ’) P + V , , + a uv, F,±L - &I +a"v - ’ R "h - IC...h,~h Here, r is the dust particle concentration. The mutual interaction force is F..Ua_____ T, Tm where Tm=4d2 p Re , Re=av(Up-U)2+(Vp-v)2 d P P

  3. Acta Armamentarii (Selected Articles).

    DTIC Science & Technology

    1986-07-08

    the position of the change point can be determined. This is very helpful in understanding the reason for unsteady burning. Therefore, this is superior...properties of CIDP propellant have been published. Domestically, there were attempts to measure the dynamic mechanical properties of solid propellants with...these three propellants are rather large. Besides the different formulas and composite concentrations, the main reason is that they have different

  4. Complete genome sequence of the Medicago microsymbiont Ensifer (Sinorhizobium) medicae strain WSM419

    SciTech Connect

    Reeve, Wayne; Chain, Patrick S. G.; O'Hara, Graham; Ardley, Julie; Nandesena, Kemanthi; Brau, Lambert; Tiwari, Ravi; Malfatti, Stephanie; Kiss, Hajnalka; Lapidus, Alla L.; Copeland, A; Nolan, Matt; Land, Miriam L; Hauser, Loren John; Chang, Yun-Juan; Ivanova, N; Mavromatis, K; Markowitz, Victor; Kyrpides, Nikos C; Gollagher, Margaret; Yates, Ron; Dilworth, Michael; Howieson, John

    2010-01-01

    Ensifer (Sinorhizobium) medicae is an effective nitrogen fixing microsymbiont of a diverse range of annual Medicago (medic) species. Strain WSM419 is an aerobic, motile, non-spore forming, Gram-negative rod isolated from a M. murex root nodule collected in Sardinia, Italy in 1981. WSM419 was manufactured commercially in Australia as an inoculant for annual medics during 1985 to 1993 due to its nitrogen fixation, saprophytic competence and acid tolerance properties. Here we describe the basic features of this organism, together with the complete genome sequence, and annotation. This is the first report of a complete genome sequence for a microsymbiont of the group of annual medic species adapted to acid soils. We reveal that its genome size is 6,817,576 bp encoding 6,518 protein-coding genes and 81 RNA only encoding genes. The genome contains a chromosome of size 3,781,904 bp and 3 plasmids of size 1,570,951 bp, 1,245,408 bp and 219,313 bp. The smallest plasmid is a feature unique to this medic microsymbiont.

  5. European Materia Medica in Historical Texts: Longevity of a Tradition and Implications for Future Use

    PubMed Central

    De Vos, Paula

    2010-01-01

    Recent research in the area of new drug discovery has shown the continued promise of looking to natural products for bioactive compounds. Researchers have thus turned to traditional medicine, which is still used widely throughout the world and increasingly in industrialized countries as well, to provide clues as to which products to investigate. The oral traditions on which much of this medical knowledge rests, however, are unstable, prompting researchers to turn to textual sources for potential drugs. This study uses Mediterranean/European medical texts from the 5th century BC to the 19th century A.D. to compile a list of the most commonly used “simples” – or single action drug substances – used in therapeutics in traditional European medicine. It finds that traditional European materia medica was based on a Dioscordean tradition that lasted through the 19th century with remarkably little variation, but is significantly different from the present-day herbal pharmacopoeia as represented by the National Institutes of Health. The most prominent simples of that tradition can thus provide clues to further bioactive compounds that have not as of yet been fully exploited for their potential, but were clearly of great use in the past. PMID:20561577

  6. Complete genome sequence of the Medicago microsymbiont Ensifer (Sinorhizobium) medicae strain WSM419

    PubMed Central

    Reeve, Wayne; Chain, Patrick; O’Hara, Graham; Ardley, Julie; Nandesena, Kemanthi; Bräu, Lambert; Tiwari, Ravi; Malfatti, Stephanie; Kiss, Hajnalka; Lapidus, Alla; Copeland, Alex; Nolan, Matt; Land, Miriam; Hauser, Loren; Chang, Yun-Juan; Ivanova, Natalia; Mavromatis, Konstantinos; Markowitz, Victor; Kyrpides, Nikos; Gollagher, Margaret; Yates, Ron; Dilworth, Michael; Howieson, John

    2010-01-01

    Ensifer (Sinorhizobium) medicae is an effective nitrogen fixing microsymbiont of a diverse range of annual Medicago (medic) species. Strain WSM419 is an aerobic, motile, non-spore forming, Gram-negative rod isolated from a M. murex root nodule collected in Sardinia, Italy in 1981. WSM419 was manufactured commercially in Australia as an inoculant for annual medics during 1985 to 1993 due to its nitrogen fixation, saprophytic competence and acid tolerance properties. Here we describe the basic features of this organism, together with the complete genome sequence, and annotation. This is the first report of a complete genome sequence for a microsymbiont of the group of annual medic species adapted to acid soils. We reveal that its genome size is 6,817,576 bp encoding 6,518 protein-coding genes and 81 RNA only encoding genes. The genome contains a chromosome of size 3,781,904 bp and 3 plasmids of size 1,570,951 bp, 1,245,408 bp and 219,313 bp. The smallest plasmid is a feature unique to this medic microsymbiont. PMID:21304680

  7. Purification and characterization of a thermostable soluble peroxidase from Citrus medica leaf.

    PubMed

    Mall, Ruckminee; Naik, Gaurav; Mina, Usha; Mishra, Sarad Kumar

    2013-01-01

    A soluble and thermostable peroxidase enzyme (POD) was extracted from the leaf of Citrus medica. The enzyme was purified 15.10-fold with a total yield of 28.6% by ammonium sulfate precipitation followed by Sephadex G-100 gel filtration chromatography. The purified enzyme came as a single band on native polyacrylamide gel electrophoresis (PAGE) as well as sodium dodecyl sulfate (SDS) PAGE. The molecular mass of the enzyme was about 32 kD as determined by SDS-PAGE. The enzyme was optimally active at pH 6.0 and 50°C temperature. The enzyme was active in wide range of pH (5.0-8.0) and temperature (30-80°C). From the thermal inactivation studies in the range of 60-75°C, the half-life (t(1/2)) values of the enzyme ranged from 8 to 173 min. The inactivation energy (Ea) value of POD was estimated to be 21.7 kcal mol(-1). The Km values for guaiacol and H(2)O(2) were 8 mM and 1.8 mM, respectively. This enzyme was activated by some metals and reagents such as Ca(2+), Cu(2+), Mg(2+), Co(2+), ferulic acid, and indole acetic acid (IAA), while it was inhibited by Fe(2+), Zn(2+), Hg(2+), and Mn(2+), L-cysteine, L-proline, and protocatechuic acid.

  8. Advances and challenges in screening traditional Chinese anti-aging materia medica.

    PubMed

    Li, Chun-Sheng; Deng, Hong-Bin; Li, Dian-Dong; Li, Zhao-He

    2013-04-01

    To provide a better service for senior health care, we summarized screening studies of traditional Chinese anti-aging materia medica (TCAM). We collected and analyzed literature of TCAM screening studies using the lifespan test and animal models of aging from 1984 to 2012. We found 26 screening methods for TCAM, and 153 single herbs or active ingredients of TCAM that have been screened out during the past 28 years. The cell lifespan test, the fruit fly lifespan test, and D-galactose aging model were the most widely used and intensively studied screening methods. However, the method for establishing the D-galactose aging model needs to be standardized, and the D-galactose aging model cannot completely be a substitute for the normal aging mouse model. Great success has been achieved in screening studies in TCAM. To further improve screening studies in TCAM, we suggest that the D-galactose aging model be incorporated into the lifespan test in the New Drugs of Traditional Chinese Medicine Research Guide.

  9. [Rapid assessment of critical quality attributes of Chinese materia medica (II): strategy of NIR assignment].

    PubMed

    Pei, Yan-Ling; Wu, Zhi-Sheng; Shi, Xin-Yuan; Zhou, Lu-Wei; Qiao, Yan-Jiang

    2014-09-01

    The present paper firstly reviewed the research progress and main methods of NIR spectral assignment coupled with our research results. Principal component analysis was focused on characteristic signal extraction to reflect spectral differences. Partial least squares method was concerned with variable selection to discover characteristic absorption band. Two-dimensional correlation spectroscopy was mainly adopted for spectral assignment. Autocorrelation peaks were obtained from spectral changes, which were disturbed by external factors, such as concentration, temperature and pressure. Density functional theory was used to calculate energy from substance structure to establish the relationship between molecular energy and spectra change. Based on the above reviewed method, taking a NIR spectral assignment of chlorogenic acid as example, a reliable spectral assignment for critical quality attributes of Chinese materia medica (CMM) was established using deuterium technology and spectral variable selection. The result demonstrated the assignment consistency according to spectral features of different concentrations of chlorogenic acid and variable selection region of online NIR model in extract process. Although spectral assignment was initial using an active pharmaceutical ingredient, it is meaningful to look forward to the futurity of the complex components in CMM. Therefore, it provided methodology for NIR spectral assignment of critical quality attributes in CMM.

  10. Effects of Chinese Materia Medica-Fubao Danggui Jiao on experimental endometriosis.

    PubMed

    Sun, Xing; Chen, Lijue; Zeng, Fanbo

    2011-01-01

    The objective of this paper was to investigate the effects of a Chinese Materia Medica variant -Fubao Danggui Jiao (FDJ)-on experimental endometriosis. An endometriosis model was created by virtue of auto-transplantation of endometrial tissue onto rats' abdominal walls. The implants were allowed to grow for 30 days until the successful completion of the model. After that, forty endometriotic rats were randomly divided into four study groups and given different treatments: (1) negative control group (water, 2ml/kg, per os); (2) FDJ-A group (FDJ, 2ml/kg, per os); (3) FDJ-B group (FDJ, 4ml/kg, per os); (4) Danazol group (70mg/kg, per os). After 30 days with treatments, the volumes of endometriotic implants in each rat were measured. The implants and normal uterine horns were removed for routine histological examination. FDJ caused significant decreases in volumes of the surviving endometriotic implants, with two different doses having statistically equivalent effects. Upon histological examination, FDJ was observed to cause regression of epithelium and stroma of endometriotic implants. FDJ had revealed promising therapeutic effects on endometriosis.

  11. Green synthesis of copper nanoparticles by Citrus medica Linn. (Idilimbu) juice and its antimicrobial activity.

    PubMed

    Shende, Sudhir; Ingle, Avinash P; Gade, Aniket; Rai, Mahendra

    2015-06-01

    We report an eco-friendly method for the synthesis of copper nanoparticles (CuNPs) using Citron juice (Citrus medica Linn.), which is nontoxic and cheap. The biogenic copper nanoparticles were characterized by UV-Vis spectrophotometer showing a typical resonance (SPR) at about 631 nm which is specific for CuNPs. Nanoparticles tracking analysis by NanoSight-LM20 showed the particles in the range of 10-60 nm with the concentration of 2.18 × 10(8) particles per ml. X-ray diffraction revealed the FCC nature of nanoparticles with an average size of 20 nm. The antimicrobial activity of CuNPs was determined by Kirby-Bauer disk diffusion method against some selected species of bacteria and plant pathogenic fungi. It was reported that the synthesized CuNPs demonstrated a significant inhibitory activity against Escherichia coli followed by Klebsiella pneumoniae, Pseudomonas aeruginosa, Propionibacterium acnes and Salmonella typhi. Among the plant pathogenic fungi tested, Fusarium culmorum was found to be most sensitive followed by F. oxysporum and F. graminearum. The novelty of this work is that for the first time citron juice was used for the synthesis of CuNPs.

  12. Extraction Optimization, Purification and Physicochemical Properties of Polysaccharides from Gynura medica.

    PubMed

    Li, Fengwei; Gao, Jian; Xue, Feng; Yu, Xiaohong; Shao, Tao

    2016-03-23

    Extraction of polysaccharides from Gynura medica (GMPs) was optimized by response surface methodology (RSM). A central composition design including three parameters, namely extraction temperature (X₁), ratio of water to raw material (X₂) and extraction time (X₃), was used. The best conditions were extraction temperature of 91.7 °C, extraction time of 4.06 h and ratio of water to raw material of 29.1 mL/g. Under the optimized conditions, the yield of GMPs was 5.56%, which was similar to the predicted polysaccharides yield of 5.66%. A fraction named GMP-1 was obtained after isolation and purification by DEAE-52 and Sephadex G-100 gel chromatography, respectively. GMP-1, with a molecular weight of 401 kDa, mainly consisted of galacturonic acid (GalA), xylose (Xyl), glucose (Glu). Infrared spectroscopy was used to characterize the major functional groups of GMP-1 and the results indicated that it was an acidic polysaccharide. The antioxidant and α-glucosidase inhibitory activities of GMPs and GMP-1 were determined in vitro. The results indicated that GMPs and GMP-1 show potential for use in functional foods or medicines.

  13. What has been overlooked on study of Chinese materia medica in the West?

    PubMed

    Liu, Willow J H

    2015-07-01

    Chinese materia medica (CMM), including Chinese herbal, animal, and mineral medicine, has been widely researched in the past century for their biological and pharmacological activities. However, their mechanism and clinical efficacy studies did not always give expected results. For example, the most commonly used Chinese herb for menstrual disorders, Radix Angelicae sinensis, showed neither estrogenic nor progesteronic activity in laboratory and clinical studies. Its efficacy should not be denied simply based on such results, because it is mostly used together with other herbs in formulae. Moreover, its regulation on menstruation may take effect through other mechanisms, such as regulation of blood circulation. The key difference of Chinese medicine (CM) from conventional medicine is its unique holistic view on human body and diseases. CMM is mostly applied in clinic in the form of formulae. Study on individual CMM, simply using methods for development of conventional drugs, is unable to thoroughly reveal the power of CMM formulae. The reason may partly result from improper design due to the lack understanding about application principle of CMMs in CM, and/or to current lack of knowledge about the causes of some symptoms and diseases. This paper will introduce the importance of qi and blood in CM etiology and pathology, Zheng differentiation, formulation of CMMs, and explain why one formula can treat different diseases and one disease can be treated with different formulae. Examples in the paper will demonstrate that proper studies on Zheng and its corresponding clinically proven formulae could help scientists find new direction to explain and treat symptoms and diseases that so far modern medicine has been unable to, provided that the designer properly understands CM theories, etiology and pathology of CM, as well as modern medicine. Strategy suggestions about research methods for CMM and its formulae will be given at the end.

  14. Effect of intracanal medicaments on push-out bond strength of Smart-Seal system

    PubMed Central

    Hegde, Vibha; Arora, Shashank

    2015-01-01

    Aim: To evaluate the effects of calcium hydroxide (CH), triple and double antibiotic pastes (DAPs) on the bond strength of Smart-Seal obturation, C-points with Endosequence Bio-ceramic (BC) sealer to the root canal dentin. Materials and Methods: Sixty-four freshly extracted single-rooted human mandibular premolars were de-coronated and prepared using rotary Pro-taper system with full sequence till F3. The specimens were randomly divided into a control group (without intracanal dressing) and 3 experimental groups that received an intracanal dressing with either CH, DAP, or triple antibiotic paste (TAP) (n = 16). The intracanal dressing was removed after 3 weeks by rinsing with 10 mL 17% ethylenediaminetetraacetic acid, followed by 10 mL 3% sodium hypochlorite. The root canals were then obturated with C-points and Endosequence BC sealer. A push-out test was used to measure the bond strength between the root canal dentin and the obturating system. The data were analyzed using two-way analysis of variance and Tukey post-hoc test. Results: The push-out bond strength values were significantly affected by the intracanal medicaments (P < 0.001), but not by the root canal thirds (P > 0.05). In the middle and apical third, the bond strength of the TAP group was higher than those of the CH and DAP groups (P < 0.05). Conclusions: The DAP and CH did not affect the bond strength of the novel hydrophilic obutrating system. TAP improved the bond strength of Smart-Seal system in the middle and apical thirds. PMID:26430308

  15. Alfalfa microsymbionts from different ITS and nodC lineages of Ensifer meliloti and Ensifer medicae symbiovar meliloti establish efficient symbiosis with alfalfa in Spanish acid soils.

    PubMed

    Ramírez-Bahena, Martha-Helena; Vargas, Margarita; Martín, María; Tejedor, Carmen; Velázquez, Encarna; Peix, Álvaro

    2015-06-01

    Alfalfa (Medicago sativa L.) is an important crop worldwide whose cropping in acid soils is hampered by the poor nodulation and yield commonly attributed to the sensitivity of its endosymbionts to acid pH. In this work, we isolated several acid-tolerant strains from alfalfa nodules in three acid soils in northwestern Spain. After grouping by RAPD fingerprinting, most strains were identified as Ensifer meliloti and only two strains as Ensifer medicae according to their 16S-23S intergenic spacer (ITS) sequences that allowed the differentiation of two groups within each one of these species. The two ITS groups of E. meliloti and the ITS group I of E. medicae have been previously found in Medicago nodules; however, the group II of E. medicae has been only found to date in Prosopis alba nodules. The analysis of the nodC gene showed that all strains isolated in this study belong to the symbiovar meliloti, grouping with the type strains of E. meliloti or E. medicae, but some harboured nodC gene alleles different from those found to date in alfalfa nodules. The strains of E. medicae belong to the symbiovar meliloti which should be also recognised in this species, although they harboured a nodC allele phylogenetically divergent to those from E. meliloti strains. Microcosm experiments showed that inoculation of alfalfa with selected acid-tolerant strains significantly increased yields in acid soils representing a suitable agricultural practice for alfalfa cropping in these soils.

  16. BOOK REVIEW: Astronomie von Olbers bis Schwarzschild. Nationale Entwicklungen und internationale Beziehungen im 19. Jahrhundert (Acta Historica Astronomiae Vol. 16)

    NASA Astrophysics Data System (ADS)

    Sterken, C.; Dick, W. R.; Hamel, J.

    2002-12-01

    The 14th volume of the Acta Historica Astronomiae is the Proceedings of a Colloquium International Relationships in Astronomy (in German) organised by the History of Astronomy Section of the Astronomische Gesellschaft held on September 18 in Lilienthal, Germany. The book contains 13 articles on astronomical topics covering the 19th and 20th centuries. The first paper is by Guenther Oestmann and deals with contemporary assessments of Johann Hieronymus Schroeter's (1745-1816) astronomical works and with later judgements of the scientific importance and significance of his observations as seen by astronomers and historians. This report is complemented by a second article on Schroeter's 25-ft reflector in Lilienthal near Bremen. To this end, author Felix Luehning has constructed a scale model of the telescope, and shows how the building of a model brings a deeper understanding of function and handling of this instrument. This brings us to a third paper on telescope building in Lilienthal: Hans-Joachim Leue describes the cooperation of Johann Hieronymus Schroeter and Johann Gottlieb Schrader in developing a white reflecting metal alloy for use as telescope mirror. The fourth article, by Klaus Schillinger, describes on the basis of archival documents the aquisition history of the Herschel telescopes, including telescope quality check, repair and building. Memorial sites referring to Wilhelm Olbers, Johann Hieronymus Schroeter, Friedrich Wilhelm Bessel and Carl Friedrich Gauss are described by Arno Langkavel in two walks outlined in the very last paper of this book. Peter Brosche, in the fifth paper, discusses the rediscovery of Ceres in December1801, a discovery that was the result of the combined efforts of a theoretician (Gauss) and an observer (Zach). Juergen Hamel's paper is based on previously unused archival sources and discusses the outstanding role played by H. C. Schumacher (1780-1850, editor of the Astronomische Nachrichten) in the communication between

  17. META-ANALYSIS OF THE SCIENTIFIC CONTENTS OF MATERIA SOCIO-MEDICA JOURNAL IN THE PERIOD 2009–2015

    PubMed Central

    Masic, Izet; Begic, Edin; Zunic, Lejla; Donev, Doncho

    2016-01-01

    Introduction: Materia Socio Medica Journal has a long history. It was founded in 1978. Aim: To evaluate journal articles in 2015 and compare findings to previous years. Material and methods: The study has retrospective and descriptive character, and included the period 2009-2015. Results: A total of 99 articles were published in Materia Socio Medica during 2015 and it shows an upward trend during the period 2009-2015. Original articles are present in majority during the last seven years (69,2%). Analyzing the last seven years, 44,1% of articles were from the field of clinical medicine. Articles from the fields of public health show an upward trend during the last four years. Collaboration rate in 2015 was 0,95. Authors of the articles are from ten countries (four continents). H index of journal is 8 and g index is 12 (Publish or Perish software). According to GoogleScholar, h5 index for Materia Socio Medica is 8 and h5 median is 9. Conclusions: The objectives of the journal in the next year are: to become a part of the Scopus and Web of Science databases, further internationalization and promotion of the journal in the country and the region, revision and broadening of the Editorial Board, trying to follow trend in reducing the number of days required for a decision on acceptance or revision of article and involvement of the younger generation of professionals and scientists into the journal work and publishing scope, which will lead to emergence of new enthusiasm and ideas (Journal intends to follow the trends of modern biomedical publishing worldwide). PMID:27047258

  18. [The archaic pronunciation of materia medica from Central Plains in the Han dynasty retained in Chinese medicinal business in Taiwan].

    PubMed

    Zhang, Xian-Zhe; Cai, Gui-Hua

    2004-10-01

    Chinese traditional medicine took its root in Taiwan together with the culture of Central Plains since our ancestors traveled to Taiwan during the turn of the Ming-Qing dynasties. For 400 years, the profession of Chinese medicine continues to develop through the transmission from fathers to sons, from tutors to disciples. During our contacts with Chinese medicinal businessmen, we found that this routinely closed and time-honored profession retained the archaic pronunciation of materia medica from Central Plains in the Han dynasty. This is a living database for studying ancient Chinese language.

  19. De Materia Medica Versus Codex Alimentarius for the Reinforcement of the Gynecologic Immune System: the Case of Endometriosis

    PubMed Central

    Vassiliadis, Simon

    2013-01-01

    Since the first Pharmacopoeia under the title “De Materia Medica,” the importance of the utilization of plants and herbs has been an invaluable medicinal tool successfully employed for strengthening the immune system for combating a number of diseases in general, or assisting fertility and reproductive issues in particular. The beneficial use of herbal extracts, constituting the basis of modern medicines, is lately under the shadow of Codex Alimentarius that threatens, if not properly applied, serious immunity features rendering the host defenseless for intercepting harmful invaders, one of which is the mesenchymal endometriotic stem cell causing endometriosis. PMID:24665212

  20. [Analysis of projects funded by NSFC in field of processing Chinese materia medica in recent five years].

    PubMed

    Chen, Lei; Xia, Xing; He, Bo-sai; Hah, Li-wei

    2015-05-01

    The general situation of the approved and concluded projects of National Natural Science Foundation of China in the field of processing Chinese Materia Medica in recent five years has been reviewed. The progresses and achievements of some projects have been summarized in accordance with research area such as the processing principle, the processing technology, quality evaluation, toxicity and safety evaluation, etc. The researchers and project support units of the funded projects have been analyzed, and the problems of the applications have been also summarized.

  1. [Study on processing adjuvant medicines in Lei Gong's treatise on preparation and broiling of materia medica (Leigong Paozhi Lun)].

    PubMed

    Zhang, Wei; Zhang, Ruixian

    2010-09-01

    There were 268 kinds of medicines recorded in the book of Lei Gong's Treatise on preparation and broiling of materia medica (Leigong Paozhi Lun). Among these medicines, 178 medicines were prepared with adjuvant medicines, including general and special compatible adjuvant medicines. These adjuvant medicines used in this book can be explained by the theory of "seven-relation compatibility". The author tried to explain the usage and their compatibility of these adjuvant medicines and put forward that attention should be paid to the changes in functions of medicines and the influences of society should be paid attention.

  2. De materia medica versus codex alimentarius for the reinforcement of the gynecologic immune system: the case of endometriosis.

    PubMed

    Vassiliadis, Simon

    2013-01-01

    Since the first Pharmacopoeia under the title "De Materia Medica," the importance of the utilization of plants and herbs has been an invaluable medicinal tool successfully employed for strengthening the immune system for combating a number of diseases in general, or assisting fertility and reproductive issues in particular. The beneficial use of herbal extracts, constituting the basis of modern medicines, is lately under the shadow of Codex Alimentarius that threatens, if not properly applied, serious immunity features rendering the host defenseless for intercepting harmful invaders, one of which is the mesenchymal endometriotic stem cell causing endometriosis.

  3. [Inheritance on and innovation of traditional Chinese medicine (TCM) flavor theory and TCM flavor standardization principle flavor theory in Compendium of Materia Medica].

    PubMed

    Zhang, Wei; Zhang, Rui-xian; Li, Jian

    2015-12-01

    All previous literatures about Chinese herbal medicines show distinctive traditional Chinese medicine (TCM) flavors. Compendium of Materia Medica is an influential book in TCM history. The TCM flavor theory and flavor standardization principle in this book has important significance for modern TCM flavor standardization. Compendium of Materia Medica pays attention to the flavor theory, explain the relations between the flavor of medicine and its therapeutic effects by means of Neo-Confucianism of the Song and Ming Dynasties. However,the book has not reflected and further developed the systemic theory, which originated in the Jin and Yuan dynasty. In Compendium of Materia Medica , flavor are standardized just by tasting medicines, instead of deducing flavors. Therefore, medicine tasting should be adopted as the major method to standardize the flavor of medicine.

  4. [Applications and spproved projects of general program, young scientist fund and fund for less developed region of national natural science funds in discipline of Chinese materia medica, NSFC in 2011].

    PubMed

    Han, Liwei; Wang, Yueyun; He, Wenbin; Zhang, Junjie; Bi, Minggang; Shang, Hongcai; Shang, Deyang; Wang, Chang'en

    2012-03-01

    The applications accepted and approved by general program, young scientist fund and fund for less developed region of national natural science funds in the discipline of Chinese materia medica, NSFC in 2011 have been introduced. The character and problems in these applications have been analyzed to give a reference to the scientists in the field of Chinese material medica.

  5. Effect of Calcium Hydroxide Based Intracanal Medicaments on the Apical Sealing Ability of Resin Based Sealer and Guttapercha Obturated Root Canals

    PubMed Central

    Sumanthini, MV; Shenoy, Vanitha U; Bodhwani, Mohit A

    2017-01-01

    Introduction Calcium Hydroxide (CH) is one of the most commonly used intracanal medicaments which can be used with various vehicles. Aim The aim of this in vitro study was to evaluate the effect of three CH based intracanal medicaments on the apical sealing ability of AH Plus – guttapercha obturation. Materials and Methods Crowns of 100 extracted single rooted human teeth were sectioned at the Cemento-Enamel Junction (CEJ) to a standardized length. The root canals were instrumented upto ISO size 40 using step back technique and the specimens were randomly divided into two control and four experimental groups. The control groups were not medicated. Specimens in positive control group (Group I) were obturated with guttapercha without placing sealer and in negative control group (Group II) were obturated with guttapercha and AH Plus sealer. Among the experimental groups, specimens of Group III were not medicated while groups IV, V and VI were medicated with CH-saline, CH-2% Chlorhexidine (CHX) and Vitapex respectively for a period of 14 days. The medicaments were removed from the specimens and the teeth were obturated with AH Plus sealer and guttapercha using lateral compaction technique. The specimens were immersed in India ink dye, demineralized and diphanized. The extent of dye penetration was assessed using a 10X stereomicroscope. Data obtained was statistically analyzed by one-way ANOVA (p<0.05) followed by Post-hoc Tukey test. Results Amongst the three CH medicaments, CH-2% CHX when used as an intracanal medicament showed a significantly higher microleakage as compared to the other groups with p<0.001. The microleakage values between the remaining groups were not statistically significant. Conclusion Under the conditions of this study it was concluded that all groups with or without intracanal medicament showed apical leakage. The vehicle used to carry CH may significantly influence the apical sealing ability of guttapercha – AH Plus obturated canals. PMID

  6. [Classes of crude drugs and its distribution of producing area in the attached illustrations in Ben cao tu jing (Illustrated Classic of Materia Medica)].

    PubMed

    Xu, T; Peng, H S

    2016-03-01

    Ben cao tu jing (Illustrated Classic of Materia Medica) is the earliest extant atlas book of materia medica in China, with 933 attached drawings. Among them, the largest portion, amounting to 670, are herbaceous plants, mostly commonly used, with definite marks of the origin producing areas, distributed across 149 administrative divisions(prefectures and counties) of the Song Dynasty, most of them in Northern area which were distributed denser than those in Southern area. The densest ones were located in Southern Shanxi, Eastern Sichuan and Eastern Anhui. In the attached drawings, the frequency of highest occurrence appeared in this Classic are three prefectures, Chuzhou, Shizhou and Guangzhou.

  7. [Investigation on pattern and methods of quality control for Chinese materia medica based on dao-di herbs and bioassay - bioassay for Coptis chinensis].

    PubMed

    Yan, Dan; Xiao, Xiao-he

    2011-05-01

    Establishment of bioassay methods is the technical issues to be faced with in the bioassay of Chinese materia medica. Taking the bioassay of Coptis chinensis Franch. as an example, the establishment process and application of the bioassay methods (including bio-potency and bio-activity fingerprint) were explained from the aspects of methodology, principle of selection, experimental design, method confirmation and data analysis. The common technologies were extracted and formed with the above aspects, so as to provide technical support for constructing pattern and method of the quality control for Chinese materia medica based on the dao-di herbs and bioassay.

  8. The Doctrine of Signatures, Materia Medica of Orchids, and the Contributions of Doctor - Orchidologists.

    PubMed

    Pearn, John

    2012-12-01

    The heritage of medicine is written in many forms. One repository is to be found in the history of orchids, the world's largest family of flowering plants. Orchids were so named by Theophrastus (c.372-288 BC) who recorded their medicinal use as an aphrodisiac and the promoter of virility, in the context of the Doctrine of Signatures. Such use endured for millennia, and was recorded both by Paracelsus (1493-1551) and Linnaeus (1707-1778). The history of orchidology and medicine are entwined in four domains: (a) orchids and their historical materia medica, within the paradigm of the Doctrine of Signatures; (b) the enduring and extensive contemporary medicinal and culinary use of orchids such as Vanilla and salep extracts of Orchis; (c) the scientific contributions of doctors as orchidologists; and (d) the heritage of more than a hundred doctors' names in the scientific etymology of the Orchidaceae family. Prominent orchidologists have included the Scottish doctor-soldier and botanist, Robert Brown (1773-1858); the Director of the State Herbarium at Leyden and the Rijks Museum, Carl Ludwig Blume (1796-1862); and Dr William Sterling MD (1888-1967). Among the more than 1250 genus names (and 33,000 species) of orchids are the names of more than a hundred doctors, their lives and works perpetuated in the scientific etymology of this family of exotic, beautiful, flamboyant, intriguing and often expensive flowers. Generic names record the lives and works of such as Aristotle (384-322BC) in Aristotelia Loureiro 1790; Cadet de Gassicourt (1769-1821) in Cadetia Gaudichaud 1826; Sir Joseph Dalton Hooker (1817-1911) in Sirhookera O. Kuntze 1891; and Dr Theodore Daniel Vrydag Zynen (fl. 1820-1850) in Vrydagzynea Blume 1858. One of the principal horticultural genera of orchids, Brassavola, records the life and work of the Ferrara and Padua physician and botanist, Antonio Musa Brassavola (1500-1555). The first Slipper Orchid bred as a hybrid, Paphiopedilum harrisianum (by John

  9. [Good agricultural practice (GAP) of Chinese materia medica (CMM) for ten years: achievements, problems and proposals].

    PubMed

    Guo, Lan-Ping; Zhang, Yan; Zhu, Shou-Dong; Wang, Gui-Hua; Wang, Xiu; Zhang, Xiao-Bo; Chen, Mei-Lan; He, Ya-Li; Han, Bang-Xing; Chen, Nai-Fu; Huang, Lu-Qi

    2014-04-01

    This paper aims to summarize the achievements during the implementation process of good agricultural practice (GAP) in Chinese Materia Medica (CMM), and on basis of analyzing the existing problems of GAP, to propose further implementation of GAP in TCM growing. Since the launch of GAP in CMM growing ten years ago, it has acquired great achievements, including: (1) The promulgation of a series of measures for the administration of the GAP approval in the CMM growing; (2) The expanded planting area of CMM; (3) The increased awareness of standardized CMM growing among farmers and enterprises; (4) The establishment of GAP implementation bases for CMM growing; (5) The improvement of theory and methodology for CMM growing; (6) The development of a large group of experts and scholars in GAP approval for CMM production. The problems existing in the production include: (1) A deep understanding of GAP and its certification is still needed; (2) The distribution of the certification base is not reasonable; (3) The geo-economics effect and the backward farming practices are thought to be the bottlenecks in the standardization of CMM growing and the scale production of CMM; (4) Low comparative effectiveness limits the development of the GAP; (5) The base of breeding improved variety is blank; (6) The immature of the cultivation technique lead to the risk of production process; (7) The degradation of soil microbial and the continuous cropping obstacle restrict the sustainable development of the GAP base. To further promote the health and orderly GAP in the CMM growing, the authors propose: (1) To change the mode of production; (2) To establish a sound standard system so as to ensure quality products for fair prices; (3) To fully consider the geo-economic culture and vigorously promote the definite cultivating of traditional Chinese medicinal materials; (4) To strengthen the transformation and generalization of basic researches and achievements, in order to provide technical

  10. Clinical and radiographical evaluation of mineral trioxide aggregate, biodentine and propolis as pulpotomy medicaments in primary teeth

    PubMed Central

    Rakesh, Kumar; Richa, Khanna

    2015-01-01

    Objectives The purpose of this study was to evaluate the efficacy of mineral trioxide aggregate (MTA), Biodentine and Propolis as pulpotomy medicaments in primary dentition, both clinically and radiographically. Materials and Methods A total of 75 healthy 3 to 10 yr old children each having at least one carious primary molar tooth were selected. Random assignment of the pulpotomy medicaments was done as follows: Group I, MTA; Group II, Biodentine; Group III, Propolis. All the pulpotomized teeth were evaluated at 3, 6, and 9 mon clinically and radiographically, based on the scoring criteria system. Results The clinical success rates were found to be similar among the three groups at 3 and 6 mon where as a significant decrease in success rate was observed in Group III (84%) compared to both Group I (100%) and Group II (100%) at 9 mon. Radiographic success rates over a period of 9 mon in Groups I, II, and III were 92, 80, and 72%, respectively. Conclusions Teeth treated with MTA and Biodentine showed more favorable clinical and radiographic success as compared to Propolis at 9 mon follow-up. PMID:26587413

  11. Optimization of Total Flavonoid Compound Extraction from Gynura medica Leaf Using Response Surface Methodology and Chemical Composition Analysis

    PubMed Central

    Liu, Wei; Yu, Yanying; Yang, Ruzhen; Wan, Chunpeng; Xu, Binbin; Cao, Shuwen

    2010-01-01

    Optimization of total flavonoid compound (TFC) extraction from Gynura medica leaf was investigated using response surface methodology (RSM) in this paper. The conditions investigated were 30–60% (v/v) ethanol concentration (X1), 85–95 °C extraction temperature (X2) and 30–50 (v/w) liquid-to-solid ratio (X3). Statistical analysis of the experiments indicated that temperature and liquid-to-solid ratio significantly affected TFC extraction (p < 0.01). The Box-Behnken experiment design showed that polynomial regression models were in good agreement with the experimental results, with the coefficients of determination of 0.9325 for TFC yield. The optimal conditions for maximum TFC yield were 55% ethanol, 92 °C and 50 (v/w) liquid-to-solid ratio with a 30 min extraction time. Extracts from these conditions showed a moderate antioxidant value of 54.78 μmol quercetin/g dry material (DM), 137.3 μmol trolox/g DM for 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 108.21 μmol quercetin/g DM, 242.31 μmol trolox/g DM for 2,2-azino-bis-(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS+), respectively. HPLC-DAD-MS analysis showed that kaempferol-3-O-glucoside was the principal flavonoid compound in Gynura medica leaf. PMID:21151469

  12. Genome sequence of Ensifer medicae Di28; an effective N2-fixing microsymbiont of Medicago murex and M. polymorpha

    PubMed Central

    2014-01-01

    Ensifer medicae Di28 is an aerobic, motile, Gram-negative, non-spore-forming rod that can exist as a soil saprophyte or as a legume microsymbiont of Medicago spp. Di28 was isolated in 1998 from a nodule recovered from the roots of M. polymorpha growing in the south east of Sardinia (Italy). Di28 is an effective microsymbiont of the annual forage legumes M. polymorpha and M. murex and is capable of establishing a partially effective symbiotic association with the perennial M. sativa. Here we describe the features of E. medicae Di28, together with genome sequence information and its annotation. The 6,553,624 bp standard draft genome is arranged into 104 scaffolds of 104 contigs containing 6,394 protein-coding genes and 75 RNA-only encoding genes. This rhizobial genome is one of 100 sequenced as part of the DOE Joint Genome Institute 2010 Genomic Encyclopedia for Bacteria and Archaea-Root Nodule Bacteria (GEBA-RNB) project. PMID:25780497

  13. Genome sequence of Ensifer medicae strain WSM1115; an acid-tolerant Medicago-nodulating microsymbiont from Samothraki, Greece.

    PubMed

    Reeve, Wayne; Ballard, Ross; Howieson, John; Drew, Elizabeth; Tian, Rui; Bräu, Lambert; Munk, Christine; Davenport, Karen; Chain, Patrick; Goodwin, Lynne; Pagani, Ioanna; Huntemann, Marcel; Mavrommatis, Konstantinos; Pati, Amrita; Markowitz, Victor; Ivanova, Natalia; Woyke, Tanja; Kyrpides, Nikos

    2014-06-15

    Ensifer medicae strain WSM1115 forms effective nitrogen fixing symbioses with a range of annual Medicago species and is used in commercial inoculants in Australia. WSM1115 is an aerobic, motile, Gram-negative, non-spore-forming rod. It was isolated from a nodule recovered from the root of burr medic (Medicago polymorpha) collected on the Greek Island of Samothraki. WSM1115 has a broad host range for nodulation and N2 fixation capacity within the genus Medicago, although this does not extend to all medic species. WSM1115 is considered saprophytically competent in moderately acid soils (pH(CaCl2) 5.0), but it has failed to persist at field sites where soil salinity exceeded 10 ECe (dS/m). Here we describe the features of E. medicae strain WSM1115, together with genome sequence information and its annotation. The 6,861,065 bp high-quality-draft genome is arranged into 7 scaffolds of 28 contigs, contains 6,789 protein-coding genes and 83 RNA-only encoding genes, and is one of 100 rhizobial genomes sequenced as part of the DOE Joint Genome Institute 2010 Genomic Encyclopedia for Bacteria and Archaea-Root Nodule Bacteria (GEBA-RNB) project.

  14. Genome sequence of Ensifer medicae Di28; an effective N2-fixing microsymbiont of Medicago murex and M. polymorpha.

    PubMed

    Garau, Giovanni; Terpolilli, Jason; Hill, Yvette; Tian, Rui; Howieson, John; Bräu, Lambert; Goodwin, Lynne; Han, James; Reddy, Tbk; Huntemann, Marcel; Pati, Amrita; Woyke, Tanja; Mavromatis, Konstantinos; Markowitz, Victor; Ivanova, Natalia; Kyrpides, Nikos; Reeve, Wayne

    2014-01-01

    Ensifer medicae Di28 is an aerobic, motile, Gram-negative, non-spore-forming rod that can exist as a soil saprophyte or as a legume microsymbiont of Medicago spp. Di28 was isolated in 1998 from a nodule recovered from the roots of M. polymorpha growing in the south east of Sardinia (Italy). Di28 is an effective microsymbiont of the annual forage legumes M. polymorpha and M. murex and is capable of establishing a partially effective symbiotic association with the perennial M. sativa. Here we describe the features of E. medicae Di28, together with genome sequence information and its annotation. The 6,553,624 bp standard draft genome is arranged into 104 scaffolds of 104 contigs containing 6,394 protein-coding genes and 75 RNA-only encoding genes. This rhizobial genome is one of 100 sequenced as part of the DOE Joint Genome Institute 2010 Genomic Encyclopedia for Bacteria and Archaea-Root Nodule Bacteria (GEBA-RNB) project.

  15. Genome sequence of Ensifer medicae strain WSM1115; an acid-tolerant Medicago-nodulating microsymbiont from Samothraki, Greece

    PubMed Central

    Reeve, Wayne; Ballard, Ross; Howieson, John; Drew, Elizabeth; Tian, Rui; Bräu, Lambert; Munk, Christine; Davenport, Karen; Chain, Patrick; Goodwin, Lynne; Pagani, Ioanna; Huntemann, Marcel; Mavrommatis, Konstantinos; Pati, Amrita; Markowitz, Victor; Ivanova, Natalia; Woyke, Tanja; Kyrpides, Nikos

    2013-01-01

    Ensifer medicae strain WSM1115 forms effective nitrogen fixing symbioses with a range of annual Medicago species and is used in commercial inoculants in Australia. WSM1115 is an aerobic, motile, Gram-negative, non-spore-forming rod. It was isolated from a nodule recovered from the root of burr medic (Medicago polymorpha) collected on the Greek Island of Samothraki. WSM1115 has a broad host range for nodulation and N2 fixation capacity within the genus Medicago, although this does not extend to all medic species. WSM1115 is considered saprophytically competent in moderately acid soils (pH(CaCl2) 5.0), but it has failed to persist at field sites where soil salinity exceeded 10 ECe (dS/m). Here we describe the features of E. medicae strain WSM1115, together with genome sequence information and its annotation. The 6,861,065 bp high-quality-draft genome is arranged into 7 scaffolds of 28 contigs, contains 6,789 protein-coding genes and 83 RNA-only encoding genes, and is one of 100 rhizobial genomes sequenced as part of the DOE Joint Genome Institute 2010 Genomic Encyclopedia for Bacteria and Archaea-Root Nodule Bacteria (GEBA-RNB) project. PMID:25197437

  16. [Effect of multicomponent environment on intestinal permeability of puerarin in biopharmaceutics classification system of Chinese materia medica].

    PubMed

    Liu, Yang; Wang, Gang; Dong, Ling; Tang, Ming-Min; Zhu, Mei-Ling; Dong, Hong-Huant; Hou, Cheng-Bo

    2014-12-01

    The evaluation of permeability in biopharmaceutics classification system of Chinese materia medica (CMMBCS) requires multicomponent as a whole in order to conduct research, even in the study of a specific component, should also be put in the multicomponent environment. Based on this principle, the high content components in Gegen Qinlian decoction were used as multicomponent environmental impact factors in the experiment, and the relevant parameters of intestinal permeability about puerarin were measured with using in situ single-pass intestinal perfusion model, to investigate and evaluate the intestinal permeability of puerarin with other high content components. The experimental results showed that different proportions of baicalin, glycyrrhizic acid and berberine had certain influence on intestinal permeability of puerarin, and glycyrrhizic acid could significantly inhibit the intestinal absorption of puerarin, moreover, high concentration of berberine could promote the absorption of puerarin. The research results indicated that the important research ideas of permeability evaluation in biopharmaceutics classification system of Chinese materia medica with fully considering the effects of other ingredients in multicomponent environment.

  17. Effect of addition of lycopene to calcium hydroxide and chlorhexidine as intracanal medicament on fracture resistance of radicular dentin at two different time intervals: An in vitro study

    PubMed Central

    Madhusudhana, Koppolu; Archanagupta, Kasamsetty; Suneelkumar, Chinni; Lavanya, Anumula; Deepthi, Mandava

    2015-01-01

    Background: Long-term use of intracanal medicaments such as calcium hydroxide (CH) reduces the fracture resistance of dentin. The present study was undertaken to evaluate the fracture resistance of radicular dentin on long-term use of CH, chlorhexidine (CHX) with lycopene (LP). Aim: To compare the fracture resistance of radicular dentin when intracanal medicaments such as CH, CHX with LP were used for 1-week and 1-month time interval. Settings and Design: Sixty single-rooted extracted human permanent premolars were collected, and complete instrumentation was done. Samples were divided into three groups based on intracanal medicament used. Materials and Methods: Group 1 - no medicament was placed (CON), group 2 - mixture of 1.5 g of CH and 1 ml of 2% CHX (CHCHX), group 3 - mixture of 1.5 g of CH, 1 ml of CHX and 1 ml of 5% LP solution (CHCHXLP). After storage period of each group for 1-week and 1-month, middle 8 mm root cylinder was sectioned and tested for fracture resistance. Statistical Analysis: Results were analyzed using paired t-test. Results: At 1-month time interval, there was a statistically significant difference in fracture resistance between CHCHX and CHCHXLP groups. Conclusion: Addition of LP has not decreased the fracture resistance of radicular dentin after 1-month. PMID:26069405

  18. A rebuttal to "A comment to 'Normalization of urinary pteridines by urine specific gravity for early cancer detection' [Clin. Chim. Acta 435 (2014) 42-47]".

    PubMed

    Ma, Yinfa; Burton, Casey; Shi, Honglan

    2015-01-01

    We really appreciate the comments from Drs. Reibnegger and Fuchs regarding our recent publication "Normalization of urinary pteridines by urine specific gravity for early cancer detection [Clin. Chim. Acta 435 (2014) 42-47]". In their letter, Drs. Reibnegger and Fuchs identify several potential concerns regarding our recent publication [1] that evaluated the normalization performance of urine specific gravity (USG) and urinary creatinine with respect to the diagnostic properties of selected pteridines in discerning aggressive and benign breast cancers. Their letter not only provides unique insights that are both relevant and helpful to many researchers engaging in similar studies, but also provides a wonderful opportunity for us to address these potential concerns that may also be shared by other readers. We addressed all of the comments by Drs. Reibnegger and Fuchs in this letter.

  19. An automated method for the determination of deoxyribonuclease activity as exemplified by fractionation of the components of the medicament Varidase.

    PubMed

    Locke, I C; Ramsey, M P; Hill, S S; Carpenter, B G

    1993-01-01

    The activity of most deoxyribonuclease enzymes can be monitored by measuring the change in absorbance at 260 nm which accompanies the breakdown of the double-stranded structure of native DNA. An automated method for determining deoxyribonuclease activity, based on such an absorbance change, which can overcome problems of inhibition arising from the presence of inorganic cations, is described. Variations in inorganic cation concentration is a particular problem when measuring the activity of chromatographic fractions eluted via a salt gradient. A comparison is made between the automated and a manual method for the assay of deoxyribonuclease active constituents, of the medicament 'Varidase', eluted from a Cellex-D (Bio-Rad Laboratories Ltd) anionic exchange resin using a 0.05-1.0 M sodium chloride gradient.

  20. [Study on supply and demand relation based on two stages division of market of Chinese materia medica].

    PubMed

    Yang, Guang; Guo, Lan-Ping; Wang, Nuo; Zeng, Yan; Huang, Lu-Qi

    2014-01-01

    The complex production processes and long industrial chain in traditional Chinese medicine (TCM) market result in difficulty in Chinese market microstructure research. Based on the defining the logical relationships among different concepts. This paper divides TCM market into two stages as Chinese materia medica resource market and traditional Chinese Patent Medicines market. Under this foundation, we investigated the supply capacity, approaching rules and motivation system of suppliers in TCM market, analyzed the demand situation in the perspective of demand side, and evaluated the purchasing power in terms of population profile, income, and insurance. Furthermore we also analyzed the price formation mechanism in two stages of TCM market. We hope this study can make a positive and promotion effect on TCM market related research.

  1. [The significance of drawing on experience of experimental study on Chinese materia medica during the Republican period].

    PubMed

    Li, Nan; Wan, Fang

    2015-05-01

    During the period of the Republic of China, researches of experiments on Chinese materia medica developed extensively with the scientific process of Chinese medicine. Although the technology standard was relatively low and the reference value, limited. The experiences, positive or negative, obtained at that time still has reference significance to today's Chinese medicine scientific research. The notion that traditional Chinese medical and scientific research be conducted under the guidance of TCM theory; valuable experience contained in the ancient literature of traditional Chinese medicine be collected; and the transformation capacity of scientific research be elevated, has been accepted by modern TCM professionals. If you go back to the history, it can be seen that this notion was summarized through repeated practice during the critical moment of traditional Chinese medicine, which should be emphasized and its understanding deepened at any time.

  2. Clinical and Radiological Evaluation of Turmeric Powder as a Pulpotomy Medicament in Primary Teeth: An in vivo Study

    PubMed Central

    Bhatt, Manohar; Purohit, Kanchan; Acharya, Jitendra; Kumar, Rajesh; Garg, Rakesh

    2017-01-01

    Many plants with biological and antimicrobiological properties have been studied since there has been a relevant increase in the incidence of antibiotic overuse and misuse. In dentistry, phytomedicines have been used as anti-inflammatory, antibiotic, analgesic, and sedative agents. Turmeric is used extensively in foods for its flavor and color, as well as having a long tradition of use in the Chinese and Ayurvedic systems of medicine, particularly as an anti-inflammatory and for the treatment of flatulence, jaundice, menstrual difficulties, hematuria, hemorrhage, and colic. This article studies ahead with a new idea of using powdered turmeric as a material of pulpotomy procedure in primary teeth. How to cite this article Purohit RN, Bhatt M, Purohit K, Acharya J, Kumar R, Garg R. Clinical and Radiological Evaluation of Turmeric Powder as a Pulpotomy Medicament in Primary Teeth: An in vivo Study. Int J Clin Pediatr Dent 2017;10(1):37-40. PMID:28377653

  3. Essential oil composition of Citrus meyerii Y. Tan. and Citrus medica L. cv. Diamante and their lemon hybrids.

    PubMed

    Verzera, Antonella; Trozzi, Alessandra; Zappalá, Mario; Condurso, Cettina; Cotroneo, Antonella

    2005-06-15

    In this paper we report the volatile fraction composition of Citrus meyerii Y. Tan. and Citrus medica L. cv. Diamante and two new lemon hybrids obtained by cross-breeding them with the tetraploid Citrus limon Burm. cv. Cavone. Both parent and hybrid oils were laboratory-extracted from the peel fruits and analyzed by HRGC-MS and HRGC-FID. Sixty-three components were fully characterized by mass spectra, linear retention indices, and injection of standards. The average composition as single components for all the oils analyzed is reported. Moreover, the data obtained were statistically analyzed. Since limonene is by far the main component of all the essential oils examined, analysis of variance and multivariate analysis gave interesting information on the similarities and differences between the oils analyzed. The new hybrid oils analyzed have potential commercial value because they could be an acceptable alternative to the valuable lemon oil.

  4. The First Mediterranean Seminar on Science Writing, Editing and Publishing, Sarajevo, December 2-3, 2016

    PubMed Central

    Masic, Izet; Donev, Doncho; Sinanovic, Osman; Jakovljevic, Miro; Zerem, Enver; Milosevic, Dejan B.; Gajovic, Srecko; Gasparyan, Armen Yuri; Sokolovic, Sekib; Salkic, Nermin; Uzunovic, Selma; Dobric, Silva; Kurti, Floreta; Begic, Edin; Kurtcehajic, Admir

    2016-01-01

    The First Mediterranean Seminar on Science Writing, Editing & Publishing (SWEP 2016) was held in Sarajevo, Bosnia & Herzegovina from 2nd to 3rd December 2016. It was organized by Academy of Medical Sciences of Bosnia and Herzegovina, running concurrent sessions as part of its Annual Meeting titled “ “Days of AMNuBiH - Theory and Practice in Science Communication and Scientometrics”. Hotel Bosnia in the city centre was the chosen venue. On the first day, nineteen presentations on various issues of science writing and publication ethics were delivered by speakers from Croatia, Serbia, Macedonia, Albania, Bosnia & Herzegovina and the UK (Asim Kurjak, Milivoj Boranić, Doncho Donev, Osman Sinanović, Miro Jakovljević, Enver Zerem, Dejan Milošević, Silva Dobrić, Srećko Gajović, Izet Mašić, Armen Yuri Gasparyan, Šekib Sokolović, Nermin Salkić, Selma Uzunović, Admir Kurtčehajić, Edin Begić and Floreta Kurti). Each presentation had a take-home message for novice and seasoned authors, encountering numerous problems in non-Anglophone research environment. Lecturers, who were internationally recognized editors of regional journals, generously shared their experience of adhering to the best ethical guidance. Elegant presentations by Srećko Gajović (Editor-in-Chief of the Croatian Medical Journal) and Armen Yuri Gasparyan (past Chief Editor of the European Science Editing) showcased their accomplishments that strengthened ties between authors from all over the world. Gasparyan reflected on educational resources of editorial associations, such as the International Committee of Medical Journal Editors (ICMJE) and the Committee on Publication Ethics (COPE), and called not just to declare the adherence to, but also to enforce their ethical guidance in daily practice. Editors of Medical Archives, Croatian Medica Journal, Vojnosanitetski Pregled, Psychiatria Danubina, Acta Informatica Medica, Materia Socio-Medica, The Donald School Journal of Ultrasound in

  5. The First Mediterranean Seminar on Science Writing, Editing and Publishing, Sarajevo, December 2-3, 2016.

    PubMed

    Masic, Izet; Donev, Doncho; Sinanovic, Osman; Jakovljevic, Miro; Zerem, Enver; Milosevic, Dejan B; Gajovic, Srecko; Gasparyan, Armen Yuri; Sokolovic, Sekib; Salkic, Nermin; Uzunovic, Selma; Dobric, Silva; Kurti, Floreta; Begic, Edin; Kurtcehajic, Admir

    2016-12-01

    The First Mediterranean Seminar on Science Writing, Editing & Publishing (SWEP 2016) was held in Sarajevo, Bosnia & Herzegovina from 2nd to 3rd December 2016. It was organized by Academy of Medical Sciences of Bosnia and Herzegovina, running concurrent sessions as part of its Annual Meeting titled " "Days of AMNuBiH - Theory and Practice in Science Communication and Scientometrics". Hotel Bosnia in the city centre was the chosen venue. On the first day, nineteen presentations on various issues of science writing and publication ethics were delivered by speakers from Croatia, Serbia, Macedonia, Albania, Bosnia & Herzegovina and the UK (Asim Kurjak, Milivoj Boranić, Doncho Donev, Osman Sinanović, Miro Jakovljević, Enver Zerem, Dejan Milošević, Silva Dobrić, Srećko Gajović, Izet Mašić, Armen Yuri Gasparyan, Šekib Sokolović, Nermin Salkić, Selma Uzunović, Admir Kurtčehajić, Edin Begić and Floreta Kurti). Each presentation had a take-home message for novice and seasoned authors, encountering numerous problems in non-Anglophone research environment. Lecturers, who were internationally recognized editors of regional journals, generously shared their experience of adhering to the best ethical guidance. Elegant presentations by Srećko Gajović (Editor-in-Chief of the Croatian Medical Journal) and Armen Yuri Gasparyan (past Chief Editor of the European Science Editing) showcased their accomplishments that strengthened ties between authors from all over the world. Gasparyan reflected on educational resources of editorial associations, such as the International Committee of Medical Journal Editors (ICMJE) and the Committee on Publication Ethics (COPE), and called not just to declare the adherence to, but also to enforce their ethical guidance in daily practice. Editors of Medical Archives, Croatian Medica Journal, Vojnosanitetski Pregled, Psychiatria Danubina, Acta Informatica Medica, Materia Socio-Medica, The Donald School Journal of Ultrasound in Obstretics

  6. Antimicrobial effect of calcium hydroxide as an intracanal medicament in root canal treatment: a literature review - Part I. In vitro studies

    PubMed Central

    2014-01-01

    The goal of endodontic treatment is the prevention and control of pulpal and periradicular infections. Calcium hydroxide (Ca(OH)2) has been widely used in endodontics as an intracanal medicament to eliminate the remaining microorganisms after chemomechanical preparation. The purpose of this article is to review the antimicrobial properties of Ca(OH)2 as an intracanal medicament in root canal treatment. The first part of this review details the characteristics of Ca(OH)2 and summarizes the results of in vitro studies related to its antimicrobial effect. The antimicrobial effect of Ca(OH)2 results from the release of hydroxyl ions when it comes into contact with aqueous fluids. Ca(OH)2 has a wide range of antimicrobial effects against common endodontic pathogens, but is less effective against Enterococcus faecalis and Candida albicans. The addition of vehicles or other agents might contribute to the antimicrobial effect of Ca(OH)2. PMID:25383341

  7. [Experience of treatment and understanding of impediment disease in Shen nong ben cao jing (Shen-ntonz's Classic of Materia Medica)].

    PubMed

    Ding, Hongchang; Wang, Zhenrui

    2015-01-01

    As a book with significant historical materials for the research of impediment disease not to be ignored, Shen nong ben cao jing (Shennong's Classic of Materia Medica) contains, among its 365 kinds of materia medica, 75 kinds of medicines related to impediment disease. Among the latter ones, 51 are related to "damp impediment", "cold-damp impediment", "wind-cold-damp impediment", "wind impediment", "wind-damp impediment", and "cold impediment"; 16 are related to "laryngeal impediment", "general impediment", and "blood impediment"; 8 are related to "muscular impediment", "stomach impediment", "hernia-conglomeration impediment", "internal consumptive-thirst impediment", "wilting impediment", and "hemiplegic impediment". To systematically analyze the properties, tastes, and effects of these medicines and its related knowledge, and then further explore the overall recognition and their treating experience of the physicians at that period would not only enrich the historical research on impediment disease, but also offer much help and reference to the understanding and treatment of impediment for contemporary clinicians.

  8. Inferring Phylogenetic Relationships of Indian Citron (Citrus medica L.) based on rbcL and matK Sequences of Chloroplast DNA.

    PubMed

    Uchoi, Ajit; Malik, Surendra Kumar; Choudhary, Ravish; Kumar, Susheel; Rohini, M R; Pal, Digvender; Ercisli, Sezai; Chaudhury, Rekha

    2016-06-01

    Phylogenetic relationships of Indian Citron (Citrus medica L.) with other important Citrus species have been inferred through sequence analyses of rbcL and matK gene region of chloroplast DNA. The study was based on 23 accessions of Citrus genotypes representing 15 taxa of Indian Citrus, collected from wild, semi-wild, and domesticated stocks. The phylogeny was inferred using the maximum parsimony (MP) and neighbor-joining (NJ) methods. Both MP and NJ trees separated all the 23 accessions of Citrus into five distinct clusters. The chloroplast DNA (cpDNA) analysis based on rbcL and matK sequence data carried out in Indian taxa of Citrus was useful in differentiating all the true species and species/varieties of probable hybrid origin in distinct clusters or groups. Sequence analysis based on rbcL and matK gene provided unambiguous identification and disposition of true species like C. maxima, C. medica, C. reticulata, and related hybrids/cultivars. The separation of C. maxima, C. medica, and C. reticulata in distinct clusters or sub-clusters supports their distinctiveness as the basic species of edible Citrus. However, the cpDNA sequence analysis of rbcL and matK gene could not find any clear cut differentiation between subgenera Citrus and Papeda as proposed in Swingle's system of classification.

  9. High-quality permanent draft genome sequence of Ensifer medicae strain WSM244, a microsymbiont isolated from Medicago polymorpha growing in alkaline soil

    DOE PAGES

    Ardley, Julie; Tian, Rui; O’Hara, Graham; ...

    2015-12-01

    We report that Ensifer medicae WSM244 is an aerobic, motile, Gram-negative, non-spore-forming rod that can exist as a soil saprophyte or as a legume microsymbiont of Medicago species. WSM244 was isolated in 1979 from a nodule recovered from the roots of the annual Medicago polymorpha L. growing in alkaline soil (pH 8.0) in Tel Afer, Iraq. WSM244 is the only acid-sensitive E. medicae strain that has been sequenced to date. It is effective at fixing nitrogen with M. polymorpha L., as well as with more alkaline-adapted Medicago spp. such as M. littoralis Loisel., M. scutellata (L.) Mill., M. tornata (L.)more » Mill. and M. truncatula Gaertn. This strain is also effective with the perennial M. sativa L. Here we describe the features of E. medicae WSM244, together with genome sequence information and its annotation. The 6,650,282 bp high-quality permanent draft genome is arranged into 91 scaffolds of 91 contigs containing 6,427 protein-coding genes and 68 RNA-only encoding genes, and is one of the rhizobial genomes sequenced as part of the DOE Joint Genome Institute 2010 Genomic Encyclopedia for Bacteria and Archaea-Root Nodule Bacteria (GEBA-RNB) project proposal.« less

  10. [A glance at the property of acupoints--analysis on functions of acupoints in view of actions of Chinese materia medica].

    PubMed

    Wang, Jun; Zhao, Ji-ping

    2008-08-01

    The acupoint is one of the basic elements of the acupuncture prescription. Just as thinking over different properties of every Chinese materia medica in a prescription, we should also sufficiently consider the characteristics of each acupoint in a prescription of acupuncture or moxibustion. Chinese materia medica have their own action-tendencies of lifting, lowering, floating and sinking, properties of cold, hot, warm and cool, five flavors of sour, bitter, sweet, acrid and salty, target-meridian distribution, different toxicity and actions, etc. What are the properties of acupoints? The authors of the present paper summarize them by simulating the characters of Chinese materia medica. It is found that acupoints also have functions in regulating lifting, lowering, floating and sinking of Qi, inducing cold and heat effects, producing different needling sensations; and pertain to different meridians (meridian distribution). And acupoint stimulation may produce adverse effects under certain specific conditions, etc. Full understanding of the properties of acupoints is definitely helpful in improving clinical therapeutic effects and shortening therapeutic courses by reasonably selecting and combining related acupoints.

  11. High-quality permanent draft genome sequence of Ensifer medicae strain WSM244, a microsymbiont isolated from Medicago polymorpha growing in alkaline soil

    SciTech Connect

    Ardley, Julie; Tian, Rui; O’Hara, Graham; Seshadri, Rekha; Reddy, T. B. K.; Pati, Amrita; Woyke, Tanja; Markowitz, Victor; Ivanova, Natalia; Kyrpides, Nikos; Howieson, John; Reeve, Wayne

    2015-12-01

    We report that Ensifer medicae WSM244 is an aerobic, motile, Gram-negative, non-spore-forming rod that can exist as a soil saprophyte or as a legume microsymbiont of Medicago species. WSM244 was isolated in 1979 from a nodule recovered from the roots of the annual Medicago polymorpha L. growing in alkaline soil (pH 8.0) in Tel Afer, Iraq. WSM244 is the only acid-sensitive E. medicae strain that has been sequenced to date. It is effective at fixing nitrogen with M. polymorpha L., as well as with more alkaline-adapted Medicago spp. such as M. littoralis Loisel., M. scutellata (L.) Mill., M. tornata (L.) Mill. and M. truncatula Gaertn. This strain is also effective with the perennial M. sativa L. Here we describe the features of E. medicae WSM244, together with genome sequence information and its annotation. The 6,650,282 bp high-quality permanent draft genome is arranged into 91 scaffolds of 91 contigs containing 6,427 protein-coding genes and 68 RNA-only encoding genes, and is one of the rhizobial genomes sequenced as part of the DOE Joint Genome Institute 2010 Genomic Encyclopedia for Bacteria and Archaea-Root Nodule Bacteria (GEBA-RNB) project proposal.

  12. High-quality permanent draft genome sequence of Ensifer medicae strain WSM244, a microsymbiont isolated from Medicago polymorpha growing in alkaline soil.

    PubMed

    Ardley, Julie; Tian, Rui; O'Hara, Graham; Seshadri, Rekha; Reddy, T B K; Pati, Amrita; Woyke, Tanja; Markowitz, Victor; Ivanova, Natalia; Kyrpides, Nikos; Howieson, John; Reeve, Wayne

    2015-01-01

    Ensifer medicae WSM244 is an aerobic, motile, Gram-negative, non-spore-forming rod that can exist as a soil saprophyte or as a legume microsymbiont of Medicago species. WSM244 was isolated in 1979 from a nodule recovered from the roots of the annual Medicago polymorpha L. growing in alkaline soil (pH 8.0) in Tel Afer, Iraq. WSM244 is the only acid-sensitive E. medicae strain that has been sequenced to date. It is effective at fixing nitrogen with M. polymorpha L., as well as with more alkaline-adapted Medicago spp. such as M. littoralis Loisel., M. scutellata (L.) Mill., M. tornata (L.) Mill. and M. truncatula Gaertn. This strain is also effective with the perennial M. sativa L. Here we describe the features of E. medicae WSM244, together with genome sequence information and its annotation. The 6,650,282 bp high-quality permanent draft genome is arranged into 91 scaffolds of 91 contigs containing 6,427 protein-coding genes and 68 RNA-only encoding genes, and is one of the rhizobial genomes sequenced as part of the DOE Joint Genome Institute 2010 Genomic Encyclopedia for Bacteria and Archaea-Root Nodule Bacteria (GEBA-RNB) project proposal.

  13. Assessment of the potential of Allium sativum oil as a new medicament for non-vital pulpotomy of primary teeth

    PubMed Central

    Mohammad, Shukry Gamal; Baroudi, Kusai

    2015-01-01

    Objective: The objective of this study was to compare the clinical and radiographic effects of Allium sativum oil and formocresol in nonvital pulpotomy in primary teeth. Materials and Methods: Twenty children ranging in age from 4 to 8 years were included in the study. In every one of those children, pulpotomy was indicated for the primary molars. Pulpotomy procedure was performed and the radicular pulp tissue of one molar was capped with A. sativum oil in a cotton pellet while the other molar was capped with formocresol. The teeth were evaluated clinically and radiographically before and after 6 months using standard clinical and radiographic criteria. Statistically, these results revealed significant difference between the radiographic findings of nonvital pulpotomy in primary molars with the two medicaments. Statistical analysis was performed using independent t-test and paired t-test at the significance level of α = 0.05. Results: A. sativum oil has potent antibacterial properties that enable it to combat intracanal microbes in the infected pulp of primary molars. Better results were obtained when A. sativum oil was used. Conclusion: A. sativum oil had more powerful effects than formocresol on the infected pulp of primary nonvital molars. PMID:26312232

  14. Clinical and Radiographic Evaluation of Allium sativum Oil as a New Medicament for Vital Pulp Treatment of Primary Teeth

    PubMed Central

    Mohammad, Shukry Gamal; Raheel, Syed Ahmed; Baroudi, Kusai

    2014-01-01

    Background: The objective of this study was to compare between the clinical and radiographic effects of Allium sativum oil and those of formocresol in vital pulpotomy in primary teeth. Materials and Methods: A total of 20 children age ranged from 4 to 8 years were included in the study. In every one of those children, the primary molars indicated for pulpotomy. Pulpotomy procedure was performed, and the radicular pulp tissue of one molar capped with A. sativum oil in a cotton pellet, whereas the other molar capped with formocresol, the teeth evaluated clinically and radiographically before and after 6 months, using standard clinical and radiographical criteria. Statistically, these results revealed no significant difference between the radiographic findings of vital pulpotomy in primary molars with the two medicaments was found. Results: A. sativum oil offers a good healing potential, leaving the remaining pulp tissue healthy and functioning. Vital pulpotomy with allium sativa oil was given raise 90% success rate while that with formocresol was 85%. Conclusion: A. sativum oil is a biocompatible material that is compatible with vital human pulp tissue. It offers a good healing potential, leaving the remaining pulp tissue healthy and functioning. PMID:25628480

  15. Clinical and radiographic comparison of various medicaments used for pulpotomy in primary molars: A randomized clinical trial

    PubMed Central

    Goyal, Prachi; Pandit, I. K.; Gugnani, Neeraj; Gupta, Monica; Goel, Richa; Gambhir, Ramandeep Singh

    2016-01-01

    Objective: To evaluate and compare the efficacy of ferric sulfate, glutaraldehyde, and mineral trioxide aggregate (MTA) as pulpotomy medicaments in primary molars. Materials and Methods: This was a perspective randomized clinical trial. A total of 90 molars from 42 children aged 4–8 years were selected for pulpotomy procedure. Teeth were randomly divided into three equal groups of 30 teeth each. Teeth in Group I were intended to be treated with ferric sulfate, Group II were intended to be treated with buffered glutaraldehyde and Group III with MTA. All the molars were evaluated clinically at 24 h and both clinically and radio graphically at 1, 3, and 6 months. The observations were statistically analyzed using Chi-square test and Fisher's exact test. Results: After 1 month, there was no clinical finding observed in all the three groups. At 3 months postoperative evaluation, 13.3% of teeth in Group I and 12.5% of teeth in Group II had mobility. At 6 months interval, pain and sinus formation each was noted in 9.1% of primary teeth in Group I while periodontal ligament widening was reported in 66.7% of teeth in Group I and 85.7% of teeth in Group II. Conclusion: MTA exhibited overall best results as pulpotomy agent for primary molars followed by 15.5% ferric sulfate, whereas 2% buffered glutaraldehyde was found to be least effective as a pulpotomy agent. PMID:27403046

  16. [Applications and prospects of on-line near infrared spectroscopy technology in manufacturing of Chinese materia medica].

    PubMed

    Li, Yang; Wu, Zhi-Sheng; Pan, Xiao-Ning; Shi, Xin-Yuan; Guo, Ming-Ye; Xu, Bing; Qiao, Yan-Jiang

    2014-10-01

    The quality of Chinese materia medica (CMM) is affected by every process in CMM manufacturing. According to multi-unit complex features in the production of CMM, on-line near infrared spectroscopy (NIR) is used as an evaluating technology with its rapid, non-destructive and non-pollution etc. advantages. With the research in institutions, the on-line NIR applied in process analysis and control of CMM was described systematically, and the on-line NIR platform building was used as an example to clarify the feasibility of on-line NIR technology in CMM manufacturing process. Then, from the point of application by pharmaceutical companies, the current on-line NIR research on CMM and its production in pharmaceutical companies was relatively comprehensively summarized. Meanwhile, the types of CMM productions were classified in accordance with two formulations (liquid and solid dosage formulations). The different production processes (extraction, concentration and alcohol precipitation, etc. ) were used as liquid formulation diacritical points; the different types (tablets, capsules and plasters, etc.) were used as solid dosage formulation diacritical points, and the reliability of on-line NIR used in the whole process in CMM production was proved in according to the summary of literatures in recent 10 years, which could support the modernization of CMM production.

  17. Distinguishing the Chinese materia medica Tiepishihu from similar Dendrobium species of the same genus using histological and microscopic method.

    PubMed

    Yu, Kun-Zi; Yan, Hua; Tai, Hai-Chuan; Zhang, Nan-Ping; Cheng, Xian-Long; Guo, Zeng-Xi; Ma, Shuang-Cheng; Wei, Feng

    2017-03-17

    The Chinese Materia Medica, Tiepishihu, used as a tonic for over one thousand years, is a well-known precious medicine in China. According to the Chinese Pharmacopoeia, its source is the species Dendrobium officinale Kimura et Migo, which is distinguished from other species in Dendrobium genus. However, these species from the same genus are similar with Tiepishihu and caused confusion in the market. To find a quick and simple method to distinguish Tiepishihu from other similar species, histologic and microscopic methods were combined together to investigate the transverse section of stem of Tiepishihu and other similar species. Phloroglucinol test solution with hydrochloric acid was used to reveal the lignified tissue by staining the transverse section of Tiepishihu and similar species. Results revealed the unique identification characteristics to distinguish Tiepishihu from similar species, which were difficult to distinguish by other methods. The identification characteristics of Tiepishihu include the cells of vascular bundle sheath were stained red, parenchyma cells were not stained red. What's more, other species can be distinguished from each other with microscopic and histological characteristics. These characteristics proved stable and can be easily observed by normal light microscopic examination. This method is rapid, accurate, stable, and inexpensive.

  18. Acta Mechanica Sinica (Selected Articles).

    DTIC Science & Technology

    1981-09-15

    Hodgkings have all tried to calculate equation (7.1) with non-steady state method. For reference, see [1, 17, 18]. They call this the dynamic...Pe,,.yu (9*16). Sci,’ua Sinea (1977), 287- 304 .- 19 J ,a.-,eieKKa*. 0. A.. MaTOMaTI4e.K11e u(ipocu ,tIHa,,K)I a3KO Nt aeiolk Nw.KrA.ocT.. l:i0IAr

  19. Acta Aeronautica et Astronautica Sinica,

    DTIC Science & Technology

    1983-07-28

    displacement of the origin in1] the various directions, and da.. = cdP . Figure l(c) shows13 Jj* the model [7) obtained by modifying the moving hardening...1 -. 𔃼 1sinl[ QQ(, - ,) + ,¢+2i.,.. - -) Q ( ) + 4,++ 24.)J The constant vector v can be determined from x (tf ) = 0. Sx ,+x 2 ,-1 o )+ F(-(X39-)e

  20. Acta Aeronautica et Astronautica Sinica,

    DTIC Science & Technology

    1982-10-14

    3 400 Fig.2 Gand specimas - 1--plate; 2--washer; 3--screw head; 4-- crack warning transducer The Ko,* at stress concentration point in the structure...628 office 1975 [4] R. E. Peterson, Design Stress Concentrating Coefficient, China Industrial Publication Co. 1965. 66 I- THE CRACK -FREE LIFE...this large scale structural component was carried out using these two spectra. The stress spectrum was obtained by directly measuring at the cracked f

  1. Acta Aeronautica et Astronautica Sinica.

    DTIC Science & Technology

    1981-12-29

    SPECIMENS 68 WITH SINGLE EDGE NOTCH Liu Ligeng, Chen Xianxi and Cai Qigong (Central Iron and Steel Research Institute) ON THE DESIGN OF TRANSONIC TURBINE...et al, Mechanism of Overload Effect on Fatigue Crack Propagation in Aluminum Alloy. Eng. Fract. Mech. 1978 No. 2. (13) Chen Hu, Cai Qigong et al...this paper. 67b J-INTEGRAL EXPERIMENTAL CALIBRATION OF SHEET SPECIMENS WITH SINGLE EDGE NOTCH Lui Ligeng, Chen Xianxi and Cai Qigong (Central Iron and

  2. Acta Aeronautica et Astronautica Sinica.

    DTIC Science & Technology

    1987-04-07

    technology. Recently the design of aircraft structure has already been developed into the stages of safety lifetime and damage tolerance. It is required to...but also influenced by the interior structures and the fatigue damages produced in manufacture and application. Iri i Ino’., although some models...downward wing. Special attention should be paid to the joint design of ,)f nomposite materials. An inadequate joint design will lead to early joint damage

  3. Acta Aeronautica et Astronautica Sinica,

    DTIC Science & Technology

    1983-03-04

    numerical subsonic solution (Sells, 1968). Example 2 was an experimental wing NACA R14 A51G31 having airfoil NACA 64A010 which is perpendicular to...perpendicular to the 1/4 chord line is NACA 64A010 . X1/4= 45 , =3, n=2 . Choose a mesh of 31xl3xl9. There are 15 sections along the half wing span. Each section...small perturbation velocity potential equation and I--±0.2 were used at the blunt leading-edge. Table 1. Computed cases of NACA RM A51G31 Wing. M. a

  4. Acta Optica Sinica (Selected Articles),

    DTIC Science & Technology

    1986-04-04

    Selected Articles) C= Approved for public release; LL 4..::.: .... y ,, .,, FTD- ID(RS)T- 1089 -85 O"V%r. - HUMAN TRANSLATION FTD-ID(RS)T- 1089 -85 4 April...OPINION OF THE FOREIGN TECHNOLOGY DIVISION WPAFB. OHIO FTo- ID(RS)T- 1089 -85 Date 4 April 19 86 GRAPHICS DISCLAIMER All figures, graphics, tables

  5. Genetic and chemical diversity of citron (Citrus medica L.) based on nuclear and cytoplasmic markers and leaf essential oil composition.

    PubMed

    Luro, François; Venturini, Nicolas; Costantino, Gilles; Paolini, Julien; Ollitrault, Patrick; Costa, Jean

    2012-05-01

    Native to southeast Asia, the citron (Citrus medica L.) was the first citrus fruit to be introduced to the Mediterranean area, in the third century BC, and remained its only citrus representative until the tenth century. The citron was used for its aroma - stemming from its essential oils in leaves and fruit peels - and as symbols in the Jewish religion. Subsequently, the cultivation of citron was extended significantly, peaking in the nineteenth century, when its fruits were used in cosmetics and confectioneries. The objective of this study was to examine the genetic diversity of the Mediterranean citron with regard to the multiplication and dissemination practices that were related to its uses. We studied the polymorphisms of 27 nuclear and cytoplasmic genetic markers of 24 citron varieties, preserved in the citrus germplasm of INRA-CIRAD, San Giuliano, France. The composition of leaf essential oils was determined to establish varieties and phylogenic relationships between accessions. Other major citrus species were included in the molecular analysis, which demonstrated the existence of 13 genetically linked citrons, differing from other citrus species, based on low heterozygosity and specific alleles; these citrons were considered true-type citrons, confirmed by their convergent chemical profiles. We also detected a polymorphism in the chloroplastic genome in these 13 citrons, which, when combined with allelic diversity of 2.4 alleles per locus, suggests that multiple citrons were introduced to the Mediterranean area in last 2 millennia. We determined the genetic origin and relationships of several varieties, such as Corsican, which could have arisen from the selfing of Poncire Commun. We noted a higher-than-expected polymorphism rate among Mediterranean citron varieties, likely due to crossfecundation. The chemical leaf oil composition of several economical varieties, such as Corsican, is distinct and can increase the quality of specific agriculture products

  6. Review of Allergic and Photoallergic Contact Dermatitis from an Ingredient in a Medicament Vehicle Consisting of a Compress, Poultice, Plaster, and Tape

    PubMed Central

    Oiso, Naoki; Kawada, Akira

    2011-01-01

    The topical application of a medicament vehicle consisting of a compress, poultice, plaster, and tape containing a nonsteroidal anti-inflammatory drug or methyl salicylate is prevalent in Japan. The method is effective for conveying ingredients to the muscles via the skin for the relief of muscular pain. However, an ingredient in the occlusive vehicle can cause allergic and photoallergic contact dermatitis. We summarize cases reported over the past decade and discuss the current strategy for diminishing the risk of allergic and photoallergic contact dermatitis. PMID:21603165

  7. Circulation and production of knowledge and scientific practices in southern America in the eighteenth century: an analysis of Materia medica misionera, a manuscript by Pedro Montenegro (1710).

    PubMed

    Fleck, Eliane Cristina Deckmann; Poletto, Roberto

    2012-12-01

    The article analyzes a 1790 manuscript copy of Materia medica misionera, a book written in 1710 by a Jesuit, Pedro Montenegro. Alongside knowledge of a magical or religious nature, and exotic ingredients for the recipes, this work also contains the unmistakable presence of Hippocratic and Galenic conceptions and a growing empiricism, characteristic of the scientific transformations seen in the eighteenth century. The analysis of this work also prompts reflections about the diffusion, circulation and production of pharmacological and medical knowledge in the first half of the eighteenth century within the missions and colleges installed in the area that was the Jesuit Province of Paraguay, southern America.

  8. Sequential cloud-point extraction for toxicological screening analysis of medicaments in human plasma by high pressure liquid chromatography with diode array detector.

    PubMed

    Madej, Katarzyna; Persona, Karolina; Wandas, Monika; Gomółka, Ewa

    2013-10-18

    A complex extraction system with the use of cloud-point extraction technique (CPE) was developed for sequential isolation of basic and acidic/neutral medicaments from human plasma/serum, screened by HPLC/DAD method. Eight model drugs (paracetamol, promazine, chlorpromazine, amitriptyline, salicyclic acid, opipramol, alprazolam and carbamazepine) were chosen for the study of optimal CPE conditions. The CPE technique consists in partition of an aqueous sample with addition of a surfactant into two phases: micelle-rich phase with the isolated compounds and water phase containing a surfactant below the critical micellar concentration, mainly under influence of temperature change. The proposed extraction system consists of two chief steps: isolation of basic compounds (from pH 12) and then isolation of acidic/neutral compounds (from pH 6) using surfactant Triton X-114 as the extraction medium. Extraction recovery varied from 25.2 to 107.9% with intra-day and inter-day precision (RSD %) ranged 0.88-1087 and 5.32-17.96, respectively. The limits of detection for the studied medicaments at λ 254nm corresponded to therapeutic or low toxic plasma concentration levels. Usefulness of the proposed CPE-HPLC/DAD method for toxicological drug screening was tested via its application to analysis of two serum samples taken from patients suspected of drug overdosing.

  9. Bioactive Glass S53P4 versus Chlorhexidine Gluconate as Intracanal Medicament in Primary Teeth: An In-vivo Study Using Polymerase Chain Reaction Analysis

    PubMed Central

    Goel, Ankit; Sinha, Abhishek; Khandeparker, Rakshit Vijay Sinai; Mehrotra, Rachit; Vashisth, Pallavi; Garg, Anuj

    2015-01-01

    Background: Bacteria have long been recognized as the primary etiology for pulpal and periapical lesions, which necessitates the elimination of bacteria from the root canal system. In primary teeth, irrigation and debridement is the main protocol required to disinfect the canal. Biomechanical preparation cannot be vigorously done on the primary teeth due to anatomical barrier such as thin and flared roots. This calls for the use of an effective intracanal medication that will assist disinfection of root canal system. Aim of the study was to examine the in-vivo susceptibility of root canal bacteria to chlorhexidine (CHX) gluconate-1% gel and bioactive glass (BAG) S53P4 when used as intracanal medicaments using polymerase chain reaction (PCR). Methodology: PCR (analysis used oligonucleotide primers of Escherichia coli) was used to detect and compare the microbial load reduction after medication of 14 teeth for a week with either CHX gel - 1% or BAG S53P4. The pre and post microbial load was checked in the form of colony forming units. When analysis was done, a statistically significant difference was observed between the two groups. Results: The study revealed that both medicaments caused a considerable amount of microbial load reduction. BAG S53P4 caused much more reduction than CHX 1% gel. Statistical analysis showed a significant difference between the two groups. Conclusion: BAG S53P4 has superior antibacterial property as compared to CHX 1% gel. PMID:26464542

  10. [The Seongho () School's Study of the Ancient Learning () and Its Influence on the Debate about Materia Medica in the Late Joseon Dynasty].

    PubMed

    Cho, Sung-San

    2015-08-01

    This study will determine the ways in which the ancient learning (gu xue, ) scholarship of the Seongho School, and its interest in the materia medica (ben cao xue, ) were related during the late Joseon period. The Seongho School centered its studies mainly on classical Chinese texts of the Han (206 BC-AD 220) and pre-Han (?-221 BC) (xian-qin lianghan, ) periods rather than those of the Tang and Song dynasties (618-1279). gu xue scholarship emerged during the Ming dynasty era (1368 -1644) as an alternative to the scholarly trends of the Song dynasty, which were dependent on Zhu Xi's (, 1130-1200) Neo-Confucianism and its interpretation of Han and pre-Han classical Chinese texts. This scholarly trend influenced Korean and Japanese literature, philosophy, and even medicine from the seventeenth through the nineteenth centuries. Focusing on Korean scholarship, we find a great deal of research regarding the influence of gu xue on Korean classical Chinese literature and Confucian philosophy in the late Joseon period; however, no study has examined how this style of scholarship influenced the field of medicine during the same period. This study will investigate how the intellectuals of the Seongho School, who did the most to develop gu xue among Joseon intellectuals, were influenced by this style of scholarship in their study of the materia medica. Jeong Yak-yong (1762-1836), the representative intellectual of the Seongho School, did not focus on complicated metaphysical medical theories, such as the Yin-Yang and Five Elements theory (yin yang wu xing shui, ) or the Five Movements and Six Atmospheres theory (wu yun liu qi shui, ). Instead, his interests lay in the exact diagnoses of diseases and meticulous herbal prescriptions which formed an essential part of the Treatise on Exogenous Febrile Disease (Shang han lun, ) written by Zhang Zhungjing (, 150-219) in the Han dynasty. The Treatise was compatible with the scholarly purpose of gu xue in that they both

  11. Automatic Verification of Serializers.

    DTIC Science & Technology

    1980-03-01

    Programming Languages, Academic Press, New York, 1968. Dijkstra 71 E. Dijkstra, Hierarchical Ordering of Sequential Processes, Acta Informatica , vol. 1...Programming Languages, Las Vegas, January 1980, 174-185. Lanipson and Redell 79 B. Lanipson, 1). RedelI , Experience with monitors and processes in

  12. Citrus medica L. cv Diamante (Rutaceae) peel extract improves glycaemic status of Zucker diabetic fatty (ZDF) rats and protects against oxidative stress.

    PubMed

    Menichini, Francesco; Tundis, Rosa; Loizzo, Monica R; Bonesi, Marco; D'Angelo, Danila; Lombardi, Pietro; Mastellone, Vincenzo

    2016-12-01

    This study aimed to investigate the antidiabetic, antilipidaemic and antioxidant activities of Citrus medica cv Diamante (Rutaceae) hydroalcoholic (CD) peel extract in Zucker diabetic fatty (ZDF) rats. The ability of CD to protect against oxidative stress was investigated by using different in vitro assays and in vivo by using the reactive oxygen metabolites-derived compounds (d-ROMs) test and the biological antioxidant potential test (BAP). Two different doses of CD extract (300 and 600 mg/kg/die) were administered at ZDF rats for 4 weeks. CD reduced cholesterol and triglycerides levels. A dose-dependent effect on body weight and serum glucose levels was observed. A decrease of d-ROMs and an increase of BAP were recorded by using the dose of 600 mg/kg. The extract inhibited lipid peroxidation (IC50 value of 0.23 mg/ml). These findings suggest as an efficient phytotherapeutic approach in combating hyperlipidaemic and hyperglycaemic disorders.

  13. An improved association-mining research for exploring Chinese herbal property theory: based on data of the Shennong's Classic of Materia Medica.

    PubMed

    Jin, Rui; Lin, Zhi-jian; Xue, Chun-miao; Zhang, Bing

    2013-09-01

    Knowledge Discovery in Databases is gaining attention and raising new hopes for traditional Chinese medicine (TCM) researchers. It is a useful tool in understanding and deciphering TCM theories. Aiming for a better understanding of Chinese herbal property theory (CHPT), this paper performed an improved association rule learning to analyze semistructured text in the book entitled Shennong's Classic of Materia Medica. The text was firstly annotated and transformed to well-structured multidimensional data. Subsequently, an Apriori algorithm was employed for producing association rules after the sensitivity analysis of parameters. From the confirmed 120 resulting rules that described the intrinsic relationships between herbal property (qi, flavor and their combinations) and herbal efficacy, two novel fundamental principles underlying CHPT were acquired and further elucidated: (1) the many-to-one mapping of herbal efficacy to herbal property; (2) the nonrandom overlap between the related efficacy of qi and flavor. This work provided an innovative knowledge about CHPT, which would be helpful for its modern research.

  14. [Preliminary textual research on Zhijintang Sanctum re-revised version of Jinling edition of Ben cao gang mu (Compendium of Materia Medica)].

    PubMed

    Zheng, Jinsheng

    2014-03-01

    The Zhijintang Sanctum version of the re-revised edition of Jinling edition of Ben cao gang mu (Compendium of Materia Medica)collected by Zhao Huiyuan of Baihe, Henan Province in 2008 was opted as one of the third batch of the National Directory of Rare Ancient Worksin 2010. On the second cover page (patent page), it is recorded as"Original Jiangxi version". However, it is investigated to find that most of its paper sheets were reprinted after the original Jinling version, only scores of paper sheets were supplemented block-printed, including the additional block-printed second preface and Li Jianyuan's submitted report of the Jiangxi version, the re-revised time of which should be after the Jiangxi edition, or 1603. The exact time can be determined only by checking it carefully against another Jinling re-revised version (the Sheyuantang Sanctum edition).

  15. In vitro susceptibility of e.faecalis and c.albicans isolates from apical periodontitis to common antimicrobial agents, antibiotics and antifungal medicaments

    PubMed Central

    Yoldas, Oguz; Yilmaz, Sehnaz; Akcimen, Beril; Seydaoglu, Gulsah; Kipalev, Arzu; Koksal, Fatih

    2012-01-01

    The aim of this study was to evaluate in vitro antimicrobial activity of 4 antibiotic agents (for E.faecalis) and 4 antifungal agents (for C.albicans) by agar dilution method. Additionally, modified strip diffusion method was used for detection of in vitro antimicrobial activities of 5% NaOCl, 2.5% NaOCl, 17% EDTA and 2% CHX and agar diffusion method for detection of in vitro susceptibilities of three intracanal medicaments for 18 E.faecalis and 18 C.albicans isolates from primary and secondary root canal infection. Isolates were recovered from 231 endodontic samples of patients, with the need of root canal treatment and retreatment. All tested E.faecalis isolates showed resistance to antibiotics. For irrigation solutions, 2% CHX was more effective in eliminating E.faecalis but 5% NaOCl showed larger inhibition zone than 2.5% NaOCl, 17% EDTA and 2% CHX. For intracanal medication, Ca(OH)2-CHX worked efficiently in killing E.faecalis isolates compared to Ca(OH)2-Steril saline solution, Ca(OH)2-Glycerin. For C.albicans, 18 isolates were susceptible to amphotericin B, nistatin, fluconazole but showed resistance to ketoconazole. 5% NaOCl was more effective in eliminating and produced larger inhibition zone compared to 2.5% NaOCl, 17% EDTA and 2% CHX. Ca(OH)2-Glycerin intracanal medication was better in eliminating C.albicans isolates and produced larger inhibition zone compared to other Ca(OH)2 medicaments. Key words:E.faecalis, C.albicans, antimicrobial, antibiotic, antifungal. PMID:24558517

  16. Chemical composition and bioactivity of Citrus medica L. cv. Diamante essential oil obtained by hydrodistillation, cold-pressing and supercritical carbon dioxide extraction.

    PubMed

    Menichini, Federica; Tundis, Rosa; Bonesi, Marco; de Cindio, Bruno; Loizzo, Monica R; Conforti, Filomena; Statti, Giancarlo A; Menabeni, Roberta; Bettini, Ruggero; Menichini, Francesco

    2011-04-01

    The chemical composition of the essential oil of Citrus medica L. cv. Diamante peel obtained by hydrodistillation, cold-pressing and supercritical carbon dioxide extraction techniques was determined by GC/MS analysis. Forty-six components were fully characterised. Limonene and γ-terpinene were the major components of the oils obtained by hydrodistillation (HD) and cold-pressing (CP), while citropten was the major constituent in the oil obtained by supercritical carbon dioxide extraction (SFE). Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities were evaluated. The essential oil obtained by hydrodistillation exerted the highest inhibitory activity against BChE (IC₅₀ value of 154.6 µg mL⁻¹) and AChE (IC₅₀ value of 171.3 µg mL⁻¹. Interestingly, the oil obtained by cold-pressing exhibited a selective inhibitory activity against AChE. The essential oils have also been evaluated for the inhibition of NO production in LPS induced RAW 264.7 macrophages. The oil obtained by hydrodistillation exerted a significant inhibition of NO production with an IC₅₀ value of 17 µg mL⁻¹ (IC₅₀ of positive control 53 µg mL⁻¹).

  17. [Textual research on Guang dong xin yu (New Sayings of Guangdong) quoted in Ben cao gang mu shi yi (Supplements to Compendium of Materia Medica].

    PubMed

    Zhang, Ruixian; Zhang, Wei; Li, Jian; Liang, Fei

    2014-05-01

    Altogether 15 terms for Guang dong xin yu (New Sayings of Guangdong) were used in Ben cao gang mu shi yi (Supplements to Compendium of Materia Medica), including Yue yu (Cantonese sayings), Chong yu (Sayings from Insect Drug), Jie yu (Sayings from Crustacean Drug), Xin yu (New Sayings), Yue hai xiang yu (Fragrant Sayings from Cantonese Region), Yue zhi mu yu (Sayings from Plants in Cantonese Annals), Guang dong suo yu (Trivial Sayings from Guangdong), Yue shan lu (Records of Cantonese Mountains), Yue lu (Cantonese Records), Jiao guang lu (Joint Guangdong Records), Yue cao zhi (Records of Cantonese Grasses), Guang guo lu (Records of Guangdong Fruits), Nan yue suo ji (Trivial Records of Southern Canton), Guang zhi (Guangdong Records), Yue zhi (Cantonese Records) etc. dealing with 57 sorts of drugs (with individual overlapping ones), the author of Xin yu was Qu Dajun, a surviving fogy of the Ming Dynasty actively involved in the activities to restore the old dynasty and resist the Qing Dynasty, and was persecuted in the literary inquisition in which his works were burnt so that Zhao Xuemin, when quoting his texts, had to go in a roundabout way.

  18. Stability and accuracy assessment of identification of traditional Chinese materia medica using DNA barcoding: a case study on Flos Lonicerae Japonicae.

    PubMed

    Hou, Dianyun; Song, Jingyuan; Shi, Linchun; Ma, Xiaochong; Xin, Tianyi; Han, Jianping; Xiao, Wei; Sun, Zhiying; Cheng, Ruiyang; Yao, Hui

    2013-01-01

    DNA barcoding is a novel molecular identification method that aids in identifying traditional Chinese materia medica using traditional identification techniques. However, further study is needed to assess the stability and accuracy of DNA barcoding. Flos Lonicerae Japonicae, a typical medicinal flower, is widely used in China, Korea, and other Southeast Asian countries. However, Flos Lonicerae Japonicae and its closely related species have been misused and traded at varying for a wide range of prices. Therefore, Flos Lonicerae Japonicae must be accurately identified. In this study, the ITS2 and psbA-trnH regions were amplified by polymerase chain reaction (PCR). Sequence assembly was performed using CodonCode Aligner V 3.5.4. The intra- versus inter-specific variations were assessed using six metrics and "barcoding gaps." Species identification was conducted using BLAST1 and neighbor-joining (NJ) trees. Results reveal that ITS2 and psbA-trnH exhibited an average intraspecific divergence of 0.001 and 0, respectively, as well as an average inter-specific divergence of 0.0331 and 0.0161. The identification efficiency of ITS2 and psbA-trnH evaluated using BLAST1 was 100%. Flos Lonicerae Japonicae was formed into one clade through the NJ trees. Therefore, Flos Lonicerae Japonicae can be stably and accurately identified through the ITS2 and psbA-trnH regions, respectively.

  19. Ameliorating effects of traditional Chinese medicine preparation, Chinese materia medica and active compounds on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage.

    PubMed

    Sun, Kai; Fan, Jingyu; Han, Jingyan

    2015-01-01

    Ischemic stroke and ischemia/reperfusion (I/R) injury induced by thrombolytic therapy are conditions with high mortality and serious long-term physical and cognitive disabilities. They have a major impact on global public health. These disorders are associated with multiple insults to the cerebral microcirculation, including reactive oxygen species (ROS) overproduction, leukocyte adhesion and infiltration, brain blood barrier (BBB) disruption, and capillary hypoperfusion, ultimately resulting in tissue edema, hemorrhage, brain injury and delayed neuron damage. Traditional Chinese medicine (TCM) has been used in China, Korea, Japan and other Asian countries for treatment of a wide range of diseases. In China, the usage of compound TCM preparation to treat cerebrovascular diseases dates back to the Han Dynasty. Even thousands of years earlier, the medical formulary recorded many classical prescriptions for treating cerebral I/R-related diseases. This review summarizes current information and underlying mechanisms regarding the ameliorating effects of compound TCM preparation, Chinese materia medica, and active components on I/R-induced cerebral microcirculatory disturbances, brain injury and neuron damage.

  20. Evaluation of antimicrobial efficacy of calcium hydroxide paste, chlorhexidine gel, and a combination of both as intracanal medicament: An in vivo comparative study

    PubMed Central

    Sinha, Nidhi; Patil, Santosh; Dodwad, Preeti Kore; Patil, Anand C; Singh, Bijay

    2013-01-01

    Aim: To compare the antimicrobial efficacy of calcium hydroxide (CH), 2% chlorhexidine gel (CHX) and a combination of both, on obligate anaerobes, facultative anaerobes and Candida spp . Materials and Methods: 90 single rooted permanent teeth were included in the study. After complete disinfection and access opening, the first microbiological pre-treatment sample (S1) was collected. After completion of instrumentation, a post-instumentation sample (S2) was taken and the teeth were divided into three groups: Group I: CH, Group II: 2% CHX, Group III: 2% CHX with CH. After 1 week, a post-medication sample (S3) was collected. Results: All three medicaments were effective in the elimination of obligate anaerobes. CHX and combination showed higher antimicrobial effect against facultative anaerobes and Candida spp. in comparison with CH. But there was no statistical significant difference between Group II and Group III. Conclusion: CHX with or without CH was more effective than CH alone against all the tested micro-organisms. PMID:23349580

  1. Insights into the history of a bacterial group II intron remnant from the genomes of the nitrogen-fixing symbionts Sinorhizobium meliloti and Sinorhizobium medicae.

    PubMed

    Toro, N; Martínez-Rodríguez, L; Martínez-Abarca, F

    2014-10-01

    Group II introns are self-splicing catalytic RNAs that act as mobile retroelements. In bacteria, they are thought to be tolerated to some extent because they self-splice and home preferentially to sites outside of functional genes, generally within intergenic regions or in other mobile genetic elements, by mechanisms including the divergence of DNA target specificity to prevent target site saturation. RmInt1 is a mobile group II intron that is widespread in natural populations of Sinorhizobium meliloti and was first described in the GR4 strain. Like other bacterial group II introns, RmInt1 tends to evolve toward an inactive form by fragmentation, with loss of the 3' terminus. We identified genomic evidence of a fragmented intron closely related to RmInt1 buried in the genome of the extant S. meliloti/S. medicae species. By studying this intron, we obtained evidence for the occurrence of intron insertion before the divergence of ancient rhizobial species. This fragmented group II intron has thus existed for a long time and has provided sequence variation, on which selection can act, contributing to diverse genetic rearrangements, and to generate pan-genome divergence after strain differentiation. The data presented here suggest that fragmented group II introns within intergenic regions closed to functionally important neighboring genes may have been microevolutionary forces driving adaptive evolution of these rhizobial species.

  2. Ameliorating effects of traditional Chinese medicine preparation, Chinese materia medica and active compounds on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage

    PubMed Central

    Sun, Kai; Fan, Jingyu; Han, Jingyan

    2015-01-01

    Ischemic stroke and ischemia/reperfusion (I/R) injury induced by thrombolytic therapy are conditions with high mortality and serious long-term physical and cognitive disabilities. They have a major impact on global public health. These disorders are associated with multiple insults to the cerebral microcirculation, including reactive oxygen species (ROS) overproduction, leukocyte adhesion and infiltration, brain blood barrier (BBB) disruption, and capillary hypoperfusion, ultimately resulting in tissue edema, hemorrhage, brain injury and delayed neuron damage. Traditional Chinese medicine (TCM) has been used in China, Korea, Japan and other Asian countries for treatment of a wide range of diseases. In China, the usage of compound TCM preparation to treat cerebrovascular diseases dates back to the Han Dynasty. Even thousands of years earlier, the medical formulary recorded many classical prescriptions for treating cerebral I/R-related diseases. This review summarizes current information and underlying mechanisms regarding the ameliorating effects of compound TCM preparation, Chinese materia medica, and active components on I/R-induced cerebral microcirculatory disturbances, brain injury and neuron damage. PMID:26579420

  3. Authentication of Polygonati Odorati Rhizoma and other two Chinese Materia Medica of the Liliaceae family by pharmacognosy technique with GC-MS analysis.

    PubMed

    Liu, Yingjiao; Liu, Canhuang; Yu, Yafei; Xu, Bei; Gong, Limin; Zeng, Xiaoyan; Xiao, Lan; Cheng, Qilai; Liu, Tasi

    2015-02-01

    Yuzhu (Polygonati Odorati Rhizoma), Kangdingyuzhu (Polygonati Prattii Rhizoma), and zhugenqiyuzhu (Disporopsis Fuscopictae Rhizoma) are of the same family, but of different genera. They have all often used in Chinese Materia Medica (CMM) as Polygonati Odorati Rhizoma in China market. Three species of CMM are confused. For better application, we need to identify these plants accurately. This study use pharmacognosy technique and GC-MS analysis, three species of CMM were authenticated. In macroscopic characteristics, the fruit of Polygonati Odorati Rhizoma is blue-black, while the other two are maroon and dark purple orderly. Nodes of Polygonati Odorati Rhizoma are upward and light uplift, about 1 cm spacing, while the other are not. As for microscopic characteristics, the cortex of Polygonati Odorati Rhizoma only occupies about 1/5 of the radius of the transverse section with inconspicuous endodermis, which is much smaller than others. The type of vascular bundles of Polygonati Odorati Rhizoma is closed collateral, but the other is amphivasal. Raphides of calcium oxalate are scattered, but Raphides of the other two are like brooms and neat rows. GC-MS analysis of essential oil could provide different characteristics to distinguish three species. Twenty-three compounds were identified from essential oil of Polygonati Odorati Rhizoma and the main components were n-hexadecanoic acid (49.45%), while n-hexadecanoic acid of the other two are 23.92% and 9.45%. The content of n-hexadecanoic is strongly different. This research was aimed to establish a method by pharmacognosy and GC-MS analysis to identify three CMM and for providing scientifical data to ensure accuracy of origin of three species.

  4. Acta Aeronautica et Astronautica Sinica (Selected Articles),

    DTIC Science & Technology

    1986-05-29

    method was developed in our country using the technique with generating lines and center lines and has been applied in various aricraft design. However...public release; Distribution unlimited. - , . 16 06 *11 Zo ! 4F , FTD- ID(RS)T-1265-85 HUMAN TRANSLATION FTD-ID(RS)T-1265-85 29 May 1986 MICROFICHE...4 4 . ,, .ii Development in Vortex Motion Research /1 Liu Mouji and Su Wenhan (Beijing Institute of Aeronautics and Astronautics) Abstract This paper

  5. Acta Aeronautica et Astronautica Sinica (Selected Articles),

    DTIC Science & Technology

    1986-05-09

    N.oreover, according to K.C. Wang’s analogue senaration criter- ion , under certain conditions, the two-dimensional unsteady flow can -- 5-I be...that the seoaration line is a convergent asymp- tote of the limiting streamlines in the vicinity of the separation line. In this sen:se, therefore

  6. Acta Aeronautica et Astronautica Sinica (Selected Articles),

    DTIC Science & Technology

    1984-11-27

    Coefficients-of the Stability Augmentation System in Order to Improve Riding Qualities, by Gao Han 13 The Compilation and Application of a State-Time...34~%*** ... . Selection of the Longitudinal Feedback Coefficients /18 of the Stability Augmentation System in Order to Improve Riding Qualities...Northwestern Polytechnical University Gao Hao ABSTRACT The longitudinal feedback coefficients of a stability augmentation system (SAS) for a sample

  7. Acta Aeronautica et Astronautica Sinica (Selected Articles),

    DTIC Science & Technology

    2014-09-26

    located at the wing tip and under the wing using flexible hangers. Different span and chord positions as well as hanger pitches , yawing and sway flexibility...causing the bending of the wing surface and pitching of the external store, and (3) flutter causing the swaying of the external store and yawing. 27...almost bent by the pitch frequency of the external store *when the pitch rigidity of the external store is low. In this * case, wing bending and twisting

  8. Acta Aeronautica et Astronautica Sinica (Selected Articles)

    DTIC Science & Technology

    1988-02-18

    tables, equations, etc. merged into this tra!,slation were extracted from the best quality copy available. I I iii ti New Content of Tactical-Technical...and Astronautics SubnmitteJ December 16, 1986 Abstrac t "This paper demionstrates the importance of stealth pane- tration ability for future military...niques, etc. The emphasis of this paper is placed on the anal- ysis of the new content of tactical-technical requirements for military aircrafts in

  9. Acta Aeronautica et Astronautica Sinica (Selected Articles),

    DTIC Science & Technology

    2014-09-26

    enthalpy drops can be increased in a single-stage type turbine by con- trolling vortices at the exhaust of the gas turbine . The number or stages is...are used in experiments and their configurations are relatively simple . Based on the existing data. the general rules of wing-tip mounted winglet...in a NH-2 low-speed wind tunnel at Nanjing Institute of Aeronautics and Astronautics. The wind speed of experiments was 40 m/s. The main wing model

  10. Acta Aeronautica et Astronautica Sinicia (Selected Articles),

    DTIC Science & Technology

    1984-01-04

    target group is I g, C ( ),(:,)..(t,), X’(0) 0 g,<x,(I,)x(,) x,(,)) o The... target groups . II. The Zero Miss Minimum Energy Guidance Law The target group is x I (tf) =0 The other parameters of the terminal are free. Based on...guidance law of the various different systems [3]. III. Guidance Laws of the Target Group as a Zero Control Intercept Curved Surface When

  11. MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats.

    PubMed

    Atkinson, Laura L; Kelly, Sandra E; Russell, James C; Bar-Tana, Jacob; Lopaschuk, Gary D

    2002-05-01

    Intracellular triacylglycerol (TG) content of liver and skeletal muscle contributes to insulin resistance, and a significant correlation exists between TG content and the development of insulin resistance. Because acetyl-CoA carboxylase (ACC) is the rate-limiting enzyme for liver fatty acid biosynthesis and a key regulator of muscle fatty acid oxidation, we examined whether ACC plays a role in the accumulation of intracellular TG. We also determined the potential role of 5'-AMP-activated protein kinase (AMPK) in this process, since it can phosphorylate and inhibit ACC activity in both liver and muscle. TG content, ACC, and AMPK were examined in the liver and skeletal muscle of insulin-resistant JCR:LA-cp rats during the time frame when insulin resistance develops. At 12 weeks of age, there was a threefold elevation in liver TG content and a sevenfold elevation in skeletal muscle TG content. Hepatic ACC activity was significantly elevated in 12-week-old JCR:LA-cp rats compared with lean age-matched controls (8.75 +/- 0.53 vs. 3.30 +/- 0.18 nmol. min(-1). mg(-1), respectively), even though AMPK activity was also increased. The observed increase in hepatic ACC activity was accompanied by a 300% increase in ACC protein expression. There were no significant differences in ACC activity, ACC protein expression, or AMPK activity in the skeletal muscle of the 12-week JCR:LA-cp rats. Treatment of 12-week JCR:LA-cp rats with MEDICA 16 (an ATP-citrate lyase inhibitor) resulted in a decrease in hepatic ACC and AMPK activities, but had no effect on skeletal muscle ACC and AMPK. Our data suggest that alterations in ACC or AMPK activity in muscle do not contribute to the development of insulin resistance. However, increased liver ACC activity in the JCR:LA-cp rat appears to contribute to the development of lipid abnormalities, although this increase does not appear to occur secondary to a decrease in AMPK activity.

  12. An In-vitro Evaluation of the pH Change Through Root Dentin Using Different Calcium Hydroxide Preparations as an Intracanal Medicament

    PubMed Central

    Manjunath, M.K.; Tejaswi, Sunil

    2014-01-01

    Context: The aim of the study was to evaluate the pH variation in the surrounding medium after the use of two different vehicles of Calcium hydroxide – Saline (aqueous), Propylene glycol (viscous) and Calcium hydroxide containing guttapercha points over a period of 7 days as an intracanal medicament. Materials and Methods: Sixty single rooted premolars were decoronated at the cementoenamel junction and cleaned and shaped uptil size 40 master apical file. External defects were made on the mesial surface in the coronal third of the roots and divided randomly into 4 groups. One control and three experimental. In the control - group I the root canals were left empty. In the experimental groups - group II was filled with Ca(OH)2 + saline, group III was filled with Ca(OH)2 + propylene glycol and group IV the root canals were filled with Calcium hydroxide points. The coronal accesses were sealed with 3mm of Cavit G and all the surfaces of the root except the defect were covered with 3 coats at Nail varnish. The samples were then placed in air tight vials containing 2ml of distilled water. The vials were kept in an incubator and the pH of the surrounding medium was measured using a digital pH meter after 1,3,5 and 7 days respectively. Results: A statistically significant difference (p<0.05) existed between the experimental groups over the observation period. At day 1, a high pH was recorded by the calcium hydroxide points and saline groups and a lower pH by the propylene group. At day’s 3 and 5, the maximum pH was recorded by the propylene glycol group and minimum by the calcium hydroxide points and saline groups. At day 7, the pH of all the groups had dropped, with propylene glycol recording the maximum pH followed by saline and lastly calcium hydroxide points. Conclusion: Within the limitations of this study, a viscous vehicle is better among other vehicles, calcium hydroxide paste of propylene glycol provided the highest 7 days release of hydroxyl ions. PMID

  13. The relevance of the urinary concentration of ephedrines in anti-doping analysis: determination of pseudoephedrine, cathine, and ephedrine after administration of over-the-counter medicaments.

    PubMed

    Strano-Rossi, Sabina; Leone, Daniele; de la Torre, Xavier; Botrè, Francesco

    2009-08-01

    This article describes a method for the detection and quantitation of cathine, pseudoephedrine, ephedrine, and methylephedrine in urine, using their deuterated analogues as internal standards and derivatization to form the corresponding trimethylsilyl derivatives after a simple liquid-liquid extraction. The study was designed to evaluate whether the urinary cutoff values set by the World Anti-Doping Agency for the banned ephedrines (cathine >5 microg/mL, ephedrine and methylephedrine >10 microg/mL) can be exceeded after the normal self-administration of common over-the-counter medicaments containing nonbanned ephedrines. The present method, after validation, has been applied on real urine samples obtained from 9 healthy volunteers taking different doses of over-the-counter preparations containing ephedrines. Results obtained from excretion studies show high interindividual differences in the urinary concentrations of both pseudoephedrine and cathine, not dependent on body weight or sex nor, in some instances, on the administered dose. The same typical therapeutic dose of pseudoephedrine (60 mg) produced a urinary concentration of more than 5 microg/mL for cathine and of more than 100 microg/mL for pseudoephedrine in 2 of 9 subjects only. When a dose of 120 mg was administered, cathine concentration exceeded 5 microg/mL in 4 of 7 subject, and also concentrations of pseudoephedrine above 100 microg/mL. After administration of 5 x 120 mg of pseudoephedrine (120 mg administered every 7 days for 5 weeks) to one of the subjects exceeding the urinary threshold values, the urinary concentration of cathine and pseudoephedrine exceeded 5 microg/mL (peak concentration 14.8 microg/mL) and 100 microg/mL (peak concentration 275 microg/mL), respectively. When the same subject took 180 mg of pseudoephedrine, the urinary concentration values were below 5 microg/mL for ephedrine and 100 microg/mL for pseudoephedrine. In the case of ephedrine administration in a sustained

  14. [Marihuana and cannobinoids as medicaments].

    PubMed

    Tkaczyk, Marek; Florek, Ewa; Piekoszewski, Wojciech

    2012-01-01

    Biological activity of cannabinoids is caused by binding to two cannabinoid receptors CB1 and CB2. Psychoactive is not only tetrahydrocannabinol (THC) but also: cannabidiol, cannabigerol or cannabichromen. Formerly, the usefulness of hemp was assessed in the relation to temporary appeasement of the symptoms of some ailments as nausea or vomiting. Present discoveries indicates that cannabis-based drugs has shown ability to alleviate of autoimmunological disorders such as: Multiple sclerosis (MS), Rheumatoid arthritis (RA) or inflammatory bowel disease. Another studies indicates that cannabinoids play role in treatment of neurological disorders like Alzheimer disease or Amyotrophic lateral sclerosis (ALS) or even can reduce spreading of tumor cells. Cannabinoids stand out high safety profile considering acute toxicity, it is low possibility of deadly overdosing and side-effects are comprise in range of tolerated side-effects of other medications. In some countries marinol and nabilone are used as anti vomiting and nausea drug. First cannabis-based drug containg naturally occurring cannabinoids is Sativex. Sativex is delivered in an mucosal spray for patients suffering from spasticity in MS, pain relevant with cancer and neuropathic pain of various origin. Despite the relatively low acute toxicity of cannabinoids they should be avoid in patients with psychotic disorders, pregnant or breastfeeding woman. Cannabinoids prolong a time of reaction and decrease power of concentration that's why driving any vehicles is forbidden. Cannabis side-effects varies and depend from several factors like administrated dose, rout of administration and present state of mind. After sudden break from long-lasting use, withdrawal symptoms can appear, although they entirely disappear after a week or two.

  15. Status Report on Image Information Systems and Image Data Base Technology

    DTIC Science & Technology

    1989-12-01

    1.6] R. Bayer and E. McCreight, Organization and Maintenance of Large Ordered Indexes, Acta Informatica , Vol. 1, No. 3, pp 173-189, 1972. [1.7] N...There are many examples, GEOVISION, ARC-INFO, a VAR (Value Added Reseller) is FSTI ( Forensic Science Technology International). (See Chapter 4...author is uncertain whether it will find a permanent place in public reading rooms or merely be a tool for library staff. Forensic Science Technology

  16. Authentication of the 31 species of toxic and potent Chinese materia medica by microscopic technique assisted by ICP-MS analysis, part 4: four kinds of toxic and potent mineral arsenical CMMs.

    PubMed

    Li, Qin; Chu, Chu; Wang, Ya-Qiong; Chen, Hu-Biao; Li, Ping; Zhao, Zhong-Zhen

    2011-01-01

    Toxic and Potent Chinese Materia Medica (T/PCMM) is a special and very important category of Chinese medicines. They have long been used in traditional medical practice and are being used more and more widely throughout the world in recent years. As there may be many fatal toxic effects caused by misusing or confusion of T/PCMM, their quality and safety control arouse increasing attention internationally. Researches on the accurate identification to ensure the safe use of T/PCMM are acquired; however, there are few reports on authentication. We are carrying out a series of studies on 31 T/PCMM originating from plants, animals, minerals, and secreta. In our previous studies, we proved that modern microscopic authentication is a simple, fast, effective, low cost, and less toxic method for identifying animal, seed, and flower T/PCMM. In the present study, we focused on the authentication of four kinds of mineral arsenicals, including orpiment (mainly containing As₂S₃), realgar (mainly containing As₄S₄), arsenolite, and arsenic trioxide (mainly containing As₂O₃). We examined the macroscopic and microscopic characteristics of the above minerals and found that they all can be easily identified and authenticated by using light microscopy coupled with polarized microscopy. Moreover, the authentication results for arsenolite and arsenic trioxide are confirmed by ICP-MS analysis. We are sure that the morphological and microscopic characteristics indicated here are indispensable to establishing standards for these four mineral T/PCMMs.

  17. Una Metodologia de Analisis de la Interaccion Alumno-Orgendaor en la Investigacion Sobre Informatica Educativa.

    ERIC Educational Resources Information Center

    Estepa, A.; And Others

    1992-01-01

    The recording of the interaction between pupil and computer is one of the data sources frequently used in research on the use of computers in teaching. Describes the analysis methodology of these recordings to determine the use of computers in statistics and its adaptation to other research work on the use of computers in education. (Author/MDH)

  18. A multi-residue method for simultaneous determination of 74 pesticides in Chinese material medica using modified QuEChERS sample preparation procedure and gas chromatography tandem mass spectrometry.

    PubMed

    Liu, Xiao-qin; Li, Yun-fei; Meng, Wen-ting; Li, Dong-xiang; Sun, Henry; Tong, Ling; Sun, Guo-xiang

    2016-03-15

    The present study is focused on the development of an analytical method for the simultaneous analysis of seventy-four pesticides belonging to different chemical classes (organochlorines, organophosphates, pyrethroids, dinitroanilines, dicarboximides, triazoles, etc.) in Chinese material medica. The samples were extracted according to the acetate QuEChERS protocol. To reduce the amount of co-extracted compounds, n-hexane instead of acetonitrile was employed as the extraction solvent. To improve the overall recoveries of problematic basic and base-sensitive compounds, sodium acetate was used to adjust the pH to a neutral condition, and florisil combined with octadecyl-modified silica (C18) were utilized in the cleanup step. The samples were analysed by GC-MS/MS, and quantified by matrix-matched calibration. The validation study was carried out on two representative herbs, Chuanxiong Rhizoma and Angelica Sinensis Radix. In two matrices, the linearity of the calibration was good between 5 and 250 ng/mL concentration ranges, and the limits of quantification (LOQs) less than 0.01 mg/kg for most pesticides. At the LOQs and ten times the LOQs, the mean recoveries of almost all pesticides were within 70-120%, with relative standard deviations (RSDs) lower than 10%. The method was applied on twenty real samples. Seven batches of Chuanxiong and five batches of Danggui were found to contain the residues. The combination of modified QuEChERS and GC-MS/MS offers low cost of analysis as well as excellent accuracy and sensitivity. This method could be especially useful for trace analysis of pesticide residues in complex matrices.

  19. Genetic and functional characterization of a yet-unclassified rhizobial Dtr (DNA-transfer-and-replication) region from a ubiquitous plasmid conjugal system present in Sinorhizobium meliloti, in Sinorhizobium medicae, and in other nonrhizobial Gram-negative bacteria.

    PubMed

    Giusti, María de los Ángeles; Pistorio, Mariano; Lozano, Mauricio J; Tejerizo, Gonzalo A Torres; Salas, María Eugenia; Martini, María Carla; López, José Luis; Draghi, Walter O; Del Papa, María Florencia; Pérez-Mendoza, Daniel; Sanjuán, Juan; Lagares, Antonio

    2012-05-01

    Rhizobia are Gram-negative bacteria that live in soils and associate with leguminous plants to establish nitrogen-fixing symbioses. The ability of these bacteria to undergo horizontal gene transfer (HGT) is thought to be one of the main features to explain both the origin of their symbiotic life-style and the plasticity and dynamics of their genomes. In our laboratory we have previously characterized at the species level the non-pSym plasmid mobilome in Sinorhizobium meliloti, the symbiont of Medicago spp., and have found a high incidence of conjugal activity in many plasmids (Pistorio et al., 2008). In this work we characterized the Dtr (DNA-transfer-and-replication) region of one of those plasmids, pSmeLPU88b. This mobilization region was found to represent a previously unclassified Dtr type in rhizobia (hereafter type-IV), highly ubiquitous in S. meliloti and found in other genera of Gram-negative bacteria as well; including Agrobacterium, Ochrobactrum, and Chelativorans. The oriT of the type-IV Dtr described here could be located by function within a DNA fragment of 278 bp, between the divergent genes parA and mobC. The phylogenetic analysis of the cognate relaxase MobZ indicated that this protein groups close to the previously defined MOB(P3) and MOB(P4) type of enzymes, but is located in a separate and novel cluster that we have designated MOB(P0). Noteworthy, MOB(P0) and MOB(P4) relaxases were frequently associated with plasmids present in rhizospheric soil bacteria. A comparison of the nod-gene locations with the phylogenetic topology of the rhizobial relaxases revealed that the symbiotic genes are found on diverse plasmids bearing any of the four Dtr types, thus indicating that pSym plasmids are not specifically associated with any particular mobilization system. Finally, we demonstrated that the type-IV Dtr promoted the mobilization of plasmids from S. meliloti to Sinorhizobium medicae as well as from these rhizobia to other bacteria by means of their own

  20. Scientometric Analysis of Scientific Validity of Medical Archives Regarding Other Medical Journals in Bosnia and Herzegovina

    PubMed Central

    Masic, Izet; Begic, Edin; Zunic, Lejla

    2016-01-01

    Introduction: Medical Archives is the oldest medical journal in Bosnia and Herzegovina (B&H) (founded in 1947.). A total of 104 articles were published in Medical Archives during 2015. Analyzing the type of articles, original articles are present in majority during 2015–80.7% (in last seven years, 561 (76%) were original out of 738). In last seven years, 651 (88.2%) articles were from the field of clinical medicine (preclinical disciplines, in the last three years are more represented than in previous years). Collaboration rate in 2015 was 0,92. Articles written in collaboration of five authors (21.1 %) are found to be predominant. From year to year, most often required time for a decision on acceptance or on the revision prior acceptance is between 50 and 60 days (30% of cases in 2015). During 2015, 47.1% of articles were originally from B&H (eleven countries were represented). H index of Medical Archive for 2014 was 12, and does not vary during the last decade. Findings: In 2015 in B&H about twenty-five journals are issued in the field of biomedical and life sciences in general (six are indexed on Medline/PubMed, one is indexed in the Science Citation Index Expanded (SCIE)/Web of Science base). According to GoogleScholar the biggest h5 index has Bosnian Journal of Basic Medical Sciences (BJBMS) and Medical Archives, while the biggest h5 median has BJBMS i Acta Informatica Medica. The highest H-index (13) in B&H has Izet Masic MD, PhD, Enver Zerem MD, PhD and Semir Vranic MD, PhD, while highest g-index (22) has Enver Zerem MD, PhD (analyzed by software package “Publish or Perish”). Conclusion: By comparing the state of medical publishing in B&H with neighboring countries (Croatia, Serbia, Montenegro), we have concluded that B&H is behind Croatia and Serbia by following parameters: Total Documents, Total Cites and H index but in front of Montenegro. PMID:26980926

  1. Meta-analysis as Statistical and Analytical Method of Journal’s Content Scientific Evaluation

    PubMed Central

    Masic, Izet; Begic, Edin

    2015-01-01

    Introduction: A meta-analysis is a statistical and analytical method which combines and synthesizes different independent studies and integrates their results into one common result. Goal: Analysis of the journals “Medical Archives”, “Materia Socio Medica” and “Acta Informatica Medica”, which are located in the most eminent indexed databases of the biomedical milieu. Material and methods: The study has retrospective and descriptive character, and included the period of the calendar year 2014. Study included six editions of all three journals (total of 18 journals). Results: In this period was published a total of 291 articles (in the “Medical Archives” 110, “Materia Socio Medica” 97, and in “Acta Informatica Medica” 84). The largest number of articles was original articles. Small numbers have been published as professional, review articles and case reports. Clinical events were most common in the first two journals, while in the journal “Acta Informatica Medica” belonged to the field of medical informatics, as part of pre-clinical medical disciplines. Articles are usually required period of fifty to fifty nine days for review. Articles were received from four continents, mostly from Europe. The authors are most often from the territory of Bosnia and Herzegovina, then Iran, Kosovo and Macedonia. Conclusion: The number of articles published each year is increasing, with greater participation of authors from different continents and abroad. Clinical medical disciplines are the most common, with the broader spectrum of topics and with a growing number of original articles. Greater support of the wider scientific community is needed for further development of all three of the aforementioned journals. PMID:25870484

  2. The Court Interpreters Act--A Step towards Equal Justice.

    ERIC Educational Resources Information Center

    Barcelo, Cosme J., Jr.

    1979-01-01

    The Court Interpreters Act of 1978, signed by President Carter on October 29, 1978, establishes the right of any individual involved in federal proceedings to have a certified court interpreter if his/her communication or comprehension capabilities are inhibited because of a language barrier or a hearing or speech impairment. (NQ)

  3. The scientific conferences organized during war time (1992-1995) in sarajevo.

    PubMed

    Masic, Izet

    2011-01-01

    Author of this paper spent 1479 days in the siege of Sarajevo, during the period of war time in Bosnia and Herzegovina (B&H). This siege, lasting from 1992 to 1995 (e.g. Dayton Piece agreement was signed in November, 1995) represents the longest siege in the history of the world. Besides usual daily work, as the associate professor of Health education, Medical deontology and Medical informatics for the students of the Faculty of medicine, Faculty of dental medicine, Faculty of Pharmacy and Nursing college of University of Sarajevo, the author organized by himself and contributors, 10 scientific conferences in a sieged Sarajevo. All presented papers at those conferences are published in Proceedings abstract books, as the proof of continuing scientific work, in Sarajevo and other cities in B&H. Additionally, the author continued to publish, in that time, unique PubMed/MedLine indexed journal, - Medical Archives, (i.e. established in 1947) and, in 1993 formed a new journal named - "Acta Informatica Medica" (AIM) , as the Journal of the Bosnian Society of Medical informatics. Bosnian Society of Medical Informatics, thus became the first scientific association from Bosnia and Herzegovina, included in 1994, in the European Federation of Medical Informatics (EFMI) and the International Medical Informatics Assiciation (IMIA) , which was "miracle" from the besieged Sarajevo and war time result of aggression on Bosnia and Herzegovina. It should be noted that the importance of maintaining these academic gatherings, in the circumstances of war, was multifaceted. First of all, thanks to these meetings, the continuity of scientific meetings and activities in the besieged city of Sarajevo was not broken, as well as the continuity of scientific publication, which was crucial for the maintenance of the teaching staff at the university and, finally, in the expansion of the "scientific truth" about what happened in Sarajevo and B&H in these difficult times. All of this was critical

  4. A national neurological excellence centers network.

    PubMed

    Pazzi, S; Cristiani, P; Cavallini, A

    1998-02-01

    The most relevant problems related to the management of neurological disorders are (i) the frequent hospitalization in nonspecialist departments, with the need for neurological consultation, and (ii) the frequent requests of GPs for highly specialized investigations that are very expensive and of little value in arriving at a correct diagnosis. In 1996, the Consorzio di Bioingegneria e Informatica Medica in Italy realized the CISNet project (in collaboration with the Consorzio Istituti Scientifici Neuroscienze e Tecnologie Biomediche and funded by the Centro Studi of the National Public Health Council) for the implementation of a national neurological excellence centers network (CISNet). In the CISNet project, neurologists will be able to give on-line interactive consultation and off-line consulting services identifying correct diagnostic/therapeutic procedures, evaluating the need for both examination in specialist centers and admission to specialized centers, and identifying the most appropriate ones.

  5. [Status and future of natural resource for Chinese materia medica].

    PubMed

    Ma, Xiao-jing; Guo, Juan; Tang, Jin-fu; Ma, Xiao-hui; Ma, Ying; Dai, Zhu-bo; Guo, Lan-ping; Huang, Lu-qi

    2015-05-01

    For thousands of years, the natural resource for Chinese materiamedica has been the foundation of the traditional Chinese medicine industry, which provides abundant medicine for human. In recent years, increasing demands and irrational exploitation led to a lot of problems such as rapid decrease of traditional Chinese herbs reserves, low quality of medicine and dismishing traditional cultures. These restricted the development of the traditional Chinese medicine. To solve these problems, scientists have done much work on investigating traditional Chinese medicine resources, exploring the metabolic pathway of bioactive ingredients, cultivating new varieties, and carrying out synthetic biology. These studies provided a theoretical basis for sustainable utilizationand future developmentof traditional Chinese medicine resources.

  6. Introduction to a Theory of Language Planning. Acta Universitatis Upsaliensis, Studia Philologiae Scandinavicae Upsaliensia, 6.

    ERIC Educational Resources Information Center

    Tauli, Valter

    Although technical and social engineering and planning have made tremendous progress, an almost prescientific attitude regarding language planning still prevails in some linguistic circles. (Language planning is defined here as the "methodical activity of regulating and improving existing languages or creating new common regional, national or…

  7. Digitalization of "Acta Stomatologica Croatica" Journal (1966;1 - 1999;33).

    PubMed

    Borić, Vesna

    2014-09-01

    Modern documents, scientific articles and books are primarily issued in electronic form and their availability depends on the publisher's, or the document owner's, business ethics. The primary purpose of publishing a scientific article is to communicate with the scientific and professional community; therefore, the published article has to be available worldwide. The question is: Who really needs scientific papers from the 1960's? In cases of brilliant and bold visionaries, new concepts and scientific discoveries often come before their time; hence they have to be "reinvented" decades later. Besides, the scientists of today can enter the spiritual spheres of their professional ancestors and give respect to their legacy.
We have processed more than 1 200 articles published by 1999 and entered more than
6 000 names and surnames of authors.

  8. Digitalization of “Acta Stomatologica Croatica” Journal (1966;1 – 1999;33)

    PubMed Central

    Borić, Vesna

    2014-01-01

    Summary Modern documents, scientific articles and books are primarily issued in electronic form and their availability depends on the publisher's, or the document owner's, business ethics. The primary purpose of publishing a scientific article is to communicate with the scientific and professional community; therefore, the published article has to be available worldwide. The question is: Who really needs scientific papers from the 1960's? In cases of brilliant and bold visionaries, new concepts and scientific discoveries often come before their time; hence they have to be "reinvented" decades later. Besides, the scientists of today can enter the spiritual spheres of their professional ancestors and give respect to their legacy.
We have processed more than 1 200 articles published by 1999 and entered more than
6 000 names and surnames of authors. PMID:27688363

  9. Acoustic Cluster Therapy (ACT)--A novel concept for ultrasound mediated, targeted drug delivery.

    PubMed

    Sontum, Per; Kvåle, Svein; Healey, Andrew John; Skurtveit, Roald; Watanabe, Rira; Matsumura, Manabu; Østensen, Jonny

    2015-11-30

    A novel approach for ultrasound (US) mediated drug delivery - Acoustic Cluster Therapy (ACT) - is proposed, and basic characteristics of the ACT formulation are elucidated. The concept comprises administration of free flowing clusters of negatively charged microbubbles and positively charged microdroplets. The clusters are activated within the target pathology by diagnostic US, undergo an ensuing liquid-to-gas phase shift and transiently deposit 20-30 μm large bubbles in the microvasculature, occluding blood flow for ∼5-10 min. Further application of US will induce biomechanical effects that increases the vascular permeability, leading to a locally enhanced extravasation of components from the vascular compartment (e.g. released or co-administered drugs). Methodologies are detailed for determination of vital in-vitro characteristics of the ACT compound; cluster concentration and size distribution. It is shown how these attributes can be engineered through various formulation parameters, and their significance as predictors of biological behaviour, such as deposit characteristics, is demonstrated by US imaging in a dog model. Furthermore, in-vivo properties of the activated ACT bubbles are studied by intravital microscopy in a rat model, confirming the postulated behaviour of the concept.

  10. Perspectives on Discourse: Proceedings from the 1998 and 1999 Discourse Symposia at Vaxjo University. Acta Wexionesia, No. 2.

    ERIC Educational Resources Information Center

    Virtanen, Tuija, Ed.; Maricic, Ibolya, Ed.

    2000-01-01

    This volume brings together the majority of lectures and papers presented at the 1998 and 1999 discourse symposia at Vaxjo University. Part one, "Four Perspectives on Discourse," offers a matrix perspective on narrative, a cross cultural perspective on academic rhetoric, a cognitive perspective on informational discourse, and a construction…

  11. Comment on "Apatite: A new redox proxy for silicic magmas?" [Geochimica et Cosmochimica Acta 132 (2014) 101-119

    NASA Astrophysics Data System (ADS)

    Marks, Michael A. W.; Scharrer, Manuel; Ladenburger, Sara; Markl, Gregor

    2016-06-01

    Recently Miles et al. (2014) proposed that a negative correlation between oxygen fugacity (expressed as logfO2 and the Mn content of apatite from a range of intermediate to silicic igneous rocks could be used as an oxybarometer (Eq. (1)).

  12. Corrigendum to "The viscosity of planetary tholeiitic melts: A configurational entropy model" [Geochim. Cosmochim. Acta 191 (2016) 277-299

    NASA Astrophysics Data System (ADS)

    Sehlke, Alexander; Whittington, Alan G.

    2017-01-01

    The authors regret some of the information presented in the original article was incorrect. The coefficients for five sub-parameters (s1 to s5) to calculate Sconf in Table 6 are incorrect, which resulted in lower Sconf values, affecting the viscosity prediction near the glass transition temperature (Tg). We provide the correct coefficients (s1 to s5) for in Table 6.

  13. Towards Understanding Leadership in Early Childhood Context: Cross-Cultural Perspectives. Acta Universitatis Ouluensis, E Scientique Rerum Socialium 35.

    ERIC Educational Resources Information Center

    Hujala, Eeva, Ed.; Puroila, Anna-Maija, Ed.

    Recognizing the importance of leadership in determining the quality of early care and education programs, the International Leadership Project (ILP) was initiated in 1996 to develop an understanding of cross-cultural perspectives on leadership, to develop a conceptual framework of leadership, and to develop cross-cultural methodologies for…

  14. Antioxidant mix: A novel pulpotomy medicament: A scanning electron microscopy evaluation

    PubMed Central

    Reddy, M. Ajay; Niharika, P.; Reddy, Harivinder; Reddy, N. Venugopal; Manoj Kumar, M. G.; Pranitha, V.

    2014-01-01

    Aim: This study aims to evaluate the clinical, radiographic, and histological success rate of antioxidant mix as a new pulpotomy agent for primary teeth. Settings and Design: Commercially available antioxidants, namely Antioxidants plus trace elements (OXIn-Xttm, India) were used. Materials and Methods: This prospective study was carried out on 36 primary molar teeth in 32 children, with age that ranged from 6 to 9 years. Regular conventional pulpotomy procedure followed by placement of antioxidant mix over the radicular orifice was done. Recall was scheduled for 3, 6, and 9 months, respectively, after treatment. Results: Thirty-six pulpotomized primary molars were available for follow-up evaluations. Scanning electron microscopy analysis of samples showing convex shaped hard tissue barrier formation may be proof of the role of antioxidant material in localization and direction and morphology of the hard tissue barrier. One tooth which presented with pain was assessed as unsuccessful. Conclusion: Quite promising clinical, radiographic, and histological results of antioxidants in the present study shows their potential to be an ideal pulpotomy agent. PMID:25395754

  15. Receta Medica: Communicating Medication Information across the Language/Literacy Divide

    ERIC Educational Resources Information Center

    Faux, Nancy R.

    2004-01-01

    Clear communication between physicians and their patients is essential for the success of any health program or intervention. In some cases, though, doctors and patients do not speak the same language. Also, patients sometimes cannot read, or they read very little in any language, including their native tongue. Occasionally, interpreters may be…

  16. Consideraciones medicas y psicologicas en ninos de 5 y 6 anos de 6 guarderias infantiles

    ERIC Educational Resources Information Center

    DeSilva, Milagros Guerra; DeViloria, Carmen Leon

    1975-01-01

    This study assessed the effect of attendance at state kindergartens of a group of 181 five- and six-year-olds from low socioeconomic backgrounds. The effects of a supplemental nutritional program as well as the children's attitudes toward attendance were considered. (MS)

  17. [Claudio Costa Casaretto M.D. (1914-1999) in Revista Medica de Chile].

    PubMed

    Goic, A

    1999-10-01

    The work of Dr. Claudio Costa Casaretto covers a broad field in the history of Medicine in Chile. He contributed with the historical aspects in the Centennial issue of Revista Médica de Chile in July, 1972. He published 85 papers in this journal in a lapse of 20 years. In his works, he investigated about medical personalities with the highest relevance for Chilean medicine such as Dr. William Blest, graduated in Edinburgh and director of the first Medicine Course in Chile in 1833, the French obstetrician Dr. Lorenzo Sazie, first Dean of the Faculty of Medicine of the University of Chile in 1843 and Dr. Eloisa Díaz, first physician graduated in Chile and South America in 1887. He published the translation from Latin of Juan Ignacio Molina's verses "Elegies to smallpox", Chilean writer and erudite of the XVIII century. He also undertook the origins of Universidad de San Felipe (1737), Universidad de Chile (1842) and Pontificia Universidad Católica de Chile (1889) and the main educational events occurred in the Faculty of Medicine of the University of Chile, during the past century. He also published about the public health situation and sanitary care during the XIX century, about the conflict between private and public teaching and other political events of the past century. The work of Dr. Costa as a whole, is a real history textbook of Chilean Medicine. Dr. Costa and Dr. Enrique Laval are the most important Chilean medical historians of the XX century.

  18. In vitro studies on interactions of iron salts and complexes with food-stuffs and medicaments.

    PubMed

    Geisser, P

    1990-07-01

    It has been shown in the present study that food components such as phytic acid, oxalic acid, tannin, sodium alginate, choline and choline salts, vitamins A, D3 and E, soy oil and soy flour, do not undergo any interactions with iron(III)-hydroxide polymaltose complex (Ferrum Hausmann). Phytic acid, oxalic acid, tannin and sodium alginate, however, react with iron(II) or iron(III)-salts at pH values of 3.0, 5.5 and 8.0, giving rise to iron complexes. Trimethylamine-N-oxide, which is present in fish meal, reacts with iron(II)-sulphate to produce iron(III) reaction products; it does not react with iron(III)-hydroxide polymaltose complex. Special soybean flours show no irreversible adsorption or precipitation with iron(III)-hydroxyide polymaltose complex over the pH range 3.0-8.0, in contrast to iron(II)-sulphate. Antacids containing aluminium hydroxide, talc, ion exchange resins or other unabsorbable, insoluble components absorb iron(III)-hydroxide polymaltose complex in the pH range 3.0-8.0 in a reversible manner, while the strong adsorption or precipitation observed with iron(II)-sulphate at pH 8.0 is irreversible. No interaction was observed between the steroid hormones studied and iron(II)-sulphate or iron(III)-hydroxide polymaltose complex. On the basis of the measured compatibilities, iron(III)-hydroxide polymaltose complex can be administered orally simultaneously with many other drugs, without prejudicing the absorption of iron or of the other drug as is often seen with iron(II) and iron(III) salts.

  19. Clinical pharmacokinetics of amoxycillin and theophylline during cotreatment with both medicaments.

    PubMed

    Jonkman, J H; van der Boon, W J; Schoenmaker, R; Holtkamp, A H; Hempenius, J

    1985-01-01

    The influence of amoxycillin and theophylline on their mutual steady-state pharmacokinetics was studied in healthy adults by comparing the pharmacokinetic parameters as obtained during a 10-day course of each drug alone and after giving the drugs in combination. Amoxycillin and theophylline plasma concentrations were measured by means of HPLC methods. On the 9th day of each of the two periods of drug administration, a concentration-time curve was evaluated. These showed no influence of theophylline on absorption, elimination or volume of distribution of amoxycillin, demonstrating that the mean steady-state plasma concentrations were not significantly different during the two treatments. Amoxycillin also has no significant effect on theophylline steady-state pharmacokinetics. It is concluded that both drugs can be given concomitantly without any dosage adjustment.

  20. Clinical pharmacokinetics of teicoplanin and aminophylline during cotreatment with both medicaments.

    PubMed

    Angrisani, M; Cazzola, M; Loffreda, A; Losasso, C; Lucarelli, C; Rossi, F

    1992-01-01

    The influence of teicoplanin and aminophylline (theophylline ethylenediamine) on their mutual steady-state pharmacokinetics was studied in two parts, namely experimental and clinical studies. The concentrations of teicoplanin and aminophylline (theophylline) were evaluated at several times after intravenous administration of teicoplanin (3 and 15 mg/kg) and aminophylline (5 mg/kg) in 12 rabbits. Ten COPD patients were treated for 5 consecutive days with a short-term intravenous infusion of 240 mg aminophylline twice daily; ten more patients received for 5 days a short-term intravenous infusion of 200 mg teicoplanin twice daily. On the last day, blood samples were taken for teicoplanin and theophylline determination by means of the HPLC method. Subsequently, while aminophylline and teicoplanin were continued at the same dosage, the first ten patients received in addition a short-term intravenous infusion of 200 mg teicoplanin twice daily, and the second ten patients a short-term intravenous infusion of 240 mg aminophylline twice daily. After 5 days the serial assays of serum teicoplanin and theophylline were repeated. Our results demonstrated, in both experimental and clinical studies, no influence of theophylline on the steady-state pharmacokinetics of teicoplanin. Likewise teicoplanin had no significant effect on the steady-state pharmacokinetics of intravenous administration of theophylline in the form of aminophylline.

  1. [Ars medica Anhaltina (V): Physicians and scientists of the Anhalt territories in Goethe's circle of friends].

    PubMed

    Kaiser, W; Völker, A

    1986-11-15

    From the view of regional history for the Anhaltine territory several medical and natural scientists are to be mentioned whom a remarkable role can be ascribed in the Weimarian circle round Goethe. The Bernburg physician and pharmaceutist Bucholz became there for many years his consultee for questions of natural sciences; Gren, who also came from Bernburg, became the antipode in the dispute about problems of optics. Goethe visited Gilbert, who was educated in Dessau, in his laboratory in Halle. In old age the poet was supported as physician and friend by Carl Vogel, born in Dessau, who described Goethe's last disease.

  2. [Ars medica Anhaltina (II): Carl Ferdinand Graefe (1787-1840) and the Alexisbad spa].

    PubMed

    Kaiser, W; Völker, A

    1986-04-15

    In 1985 the spa Alexisbad in the Harz Mountains celebrated the 175th anniversary of its creation. Its establishment is to be seen in close connection with the activities of the subsequent Berlin professor in ordinary Carl Ferdinand Graefe (1787-1840) in Anhalt-Bernburg. The early development of the spa which for a certain time was fused with the Beringerbrunnen in Suderode is characterized by the activities of several engaged sanatory physicians whose spectre of task allows insights in the balneological organisation of the 19th century.

  3. La linguistica, la glottodidattica e l'elaboratore elettronico: Note sull'introduzione dell'informatica nell'insegnamento delle lingue (Linguistics, Language Pedagogy, and Computers: Notes on the Introduction of Computer Science in the Teaching of Languages).

    ERIC Educational Resources Information Center

    Colmayer, Ciro

    1991-01-01

    Attempts to show that the use of computers in the classroom should not be limited to the teaching of math but that the language classroom is an even more appropriate place for the introduction and use of computers. (CFM)

  4. Stability of the IMEX Methods, CNLF and BDF2-AB2, for Uncoupling Systems of Evolution Equations

    DTIC Science & Technology

    2011-02-01

    Implicit-Explicit linear multistep methods, Tech. rep., Centrum Wiskunde and Informatica (CWI) (1996). [14] W. Hundsdorfer, J. Verwer, Numerical...component splitting for the Crank-Nicolson Leap- Frog integration method, Tech. rep., Centrum Wiskunde and Informatica (CWI) (2009). [23] J. Verwer

  5. Toward the Attribution of Web Behavior

    DTIC Science & Technology

    2012-07-01

    den Poel, “Predicting website audience demo- graphics for Web advertising targeting using multi-website clickstream data,” Fundamenta Informaticae ...and M. Sydow, “Effective prediction of web user behaviour with user-level models,” Fundamenta Informaticae , vol. 89, no. 2, pp. 189–206, 2008. [24] J

  6. Close Combat Missile Methodology Study

    DTIC Science & Technology

    2010-10-14

    Modeling: Industrial Applications of DEX.” Informatica 23 (1999): 487-491. Bohanec, Marko, Blaz Zupan, and Vladislav Rajkovic. “Applications of...Lisec. “Multi-attribute Decision Analysis in GIS: Weighted Linear Combination and Ordered Weighted Averaging.” Informatica 33, (1999): 459- 474

  7. Reply to "Comment on papers by K. Shanahan that propose to explain anomalous heat generated by cold fusion", E. Storms, Thermochim. Acta (2005)

    SciTech Connect

    Shanahan, Kirk

    2005-09-21

    Dr. E. Storms has published a Letter [1] in which he argues that in a sequence of recent papers [2-5], the apparent excess heat signal claimed by Dr. Shanahan to arise from a calibration constant shift is actually true excess heat. In particular he proposes that the mechanisms proposed that foster the proposed calibration constant shifts [3,5] cannot occur as postulated for several reasons. As well, he proposes Shanahan has ignored the extant data proving this. Because this Letter may lend unwarranted support to acceptance of cold fusion claims, these erroneous arguments used by Storms need to be answered.

  8. Simposio sobre Educacion de Ninas: Evidencias, Temas, Acciones. Actas de sesiones. (Symposium on Girls Education: Evidence, Issues, Actions. Proceedings). (Washington, DC, May 17-18, 2000).

    ERIC Educational Resources Information Center

    Agency for International Development (IDCA), Washington, DC.

    This symposium highlighted core issues of controversy in girls' education and developed implications for policy and practice. Its evidence-based discussion forum encouraged dialogue, debate, and increased interaction and developed partnerships among academic institutions, nongovernmental organizations, multilateral development agencies, and other…

  9. Erratum to "Combustion oscillation study in a kerosene fueled rocket-based combined-cycle engine combustor" [Acta Astronaut. 129 (2016) 260-270

    NASA Astrophysics Data System (ADS)

    Huang, Zhi-Wei; He, Guo-Qiang; Qin, Fei; Xue, Rui; Wei, Xiang-Geng; Shi, Lei

    2017-03-01

    The publisher regrets that in the above article we found that Table 1 is present online, in the html version in ScienceDirect, but has been omitted in error from the final version of the PDF online and in the print version. The table can be found below:

  10. Reply to comment by Marks et al. (2016) on "Apatite: A new redox proxy for silicic magmas?" [Geochimica et Cosmochimica Acta 132 (2014) 101-119

    NASA Astrophysics Data System (ADS)

    Miles, Andrew; Graham, Colin; Hawkesworth, Chris; Gillespie, Martin; Hinton, Richard; Bromiley, Geoffrey

    2016-06-01

    Marks et al. (2016) investigate the applicability of the Mn-in-apatite oxybarometer proposed by Miles et al. (2014) across a range of magma compositions using published data on well-characterised samples. The authors show that for magma compositions outside of the calc-alkaline and intermediate to silicic range used in the preliminary calibration, fO2 values calculated from Mn-in-apatite vary significantly from independently constrained estimates. These data are used to reiterate our warnings that other controls that are additional to oxygen fugacity are likely to affect Mn partitioning into apatite in some rock types, and particularly so in magmas that lie outside of the range of compositions and conditions used in the calibration. Marks et al. (2016) highlight that temperature may have an especially important effect on Mn partitioning in apatite in some rock types.

  11. Tiny tweaks, big changes: An alternative strategy to empower ethical culture of human research in anesthesia (A Taiwan Acta Anesthesiologica Taiwanica-Ethics Review Task Force Report).

    PubMed

    Luk, Hsiang-Ning; Ennever, John F; Day, Yuan-Ji; Wong, Chih-Shung; Sun, Wei-Zen

    2015-03-01

    For this guidance article, the Ethics Review Task Force (ERTF) of the Journal reviewed and discussed the ethics issues related to publication of human research in the field of anesthesia. ERTF first introduced international ethics principles and minimal requirements of reporting of ethics practices, followed by discussing the universal problems of publication ethics. ERTF then compared the accountability and methodology of several medical journals in assuring authors' ethics compliance. Using the Taiwan Institutional Review Board system as an example, ERTF expressed the importance of institutional review board registration and accreditation to assure human participant protection. ERTF presented four major human research misconducts in the field of anesthesia in recent years. ERTF finally proposed a flow-chart to guide journal peer reviewers and editors in ethics review during the editorial process in publishing. Examples of template languages applied in the Ethics statement section in the manuscript are expected to strengthen the ethics compliance of the authors and to set an ethical culture for all the stakeholders involved in human research.

  12. Curriculum Perspectives: Challenges for the Future. Proceedings of a Binational Symnposium = Perspectivas curriculares: Retos para el futuro. Actas del simposio binacional (Austin, Texas, November 9-10, 1994).

    ERIC Educational Resources Information Center

    Southwest Educational Development Lab., Austin, TX.

    This proceedings, in English and Spanish, describes the first U.S./Mexico Curriculum Symposium, held in Austin, Texas, in November 1994. The symposium grew out of an ongoing exchange between educators in the Republic of Mexico and the United States and was attended by over 200 teachers, administrators, staff from state and regional education…

  13. Corrigendum to "Equilibrium magnesium isotope fractionation between aqueous Mg2+ and carbonate minerals: Insights from path integral molecular dynamics" [Geochim. Cosmochim. Acta 163 (2015) 126-139

    NASA Astrophysics Data System (ADS)

    Pinilla, Carlos; Blanchard, Marc; Balan, Etienne; Natarajan, Suresh K.; Vuilleumier, Rodolphe; Mauri, Francesco

    2015-10-01

    The theoretical 26Mg/24Mg β-factor of aqueous Mg2+ of Schauble (2011) has been reported with an error in Pinilla et al. (2015). The corresponding value in Table 7 is incorrect and should read 25.5‰ at 298 K. In Section 3.6 (page 133), one sentence is affected and should be rephrased as: "It is noteworthy that the estimate of the Mg(aq)β-factor from a set of salts containing the Mg(H20)62+ complex leads to a value ∼2‰ higher than the other estimates at 298 K." Finally, the curves in Fig. 8 corresponding to the calculations of Schauble (2011) have been corrected in the figure below.

  14. Nationwide program of education for undergraduates in the field of disaster medicine: development of a core curriculum centered on blended learning and simulation tools.

    PubMed

    Ingrassia, Pier Luigi; Ragazzoni, Luca; Tengattini, Marco; Carenzo, Luca; Della Corte, Francesco

    2014-10-01

    In recent years, effective models of disaster medicine curricula for medical schools have been established. However, only a small percentage of medical schools worldwide have considered at least basic disaster medicine teaching in their study program. In Italy, disaster medicine has not yet been included in the medical school curriculum. Perceiving the lack of a specific course on disaster medicine, the Segretariato Italiano Studenti in Medicina (SISM) contacted the Centro di Ricerca Interdipartimentale in Medicina di Emergenza e dei Disastri ed Informatica applicata alla didattica e alla pratica Medica (CRIMEDIM) with a proposal for a nationwide program in this field. Seven modules (introduction to disaster medicine, prehospital disaster management, definition of triage, characteristics of hospital disaster plans, treatment of the health consequences of different disasters, psychosocial care, and presentation of past disasters) were developed using an e-learning platform and a 12-hour classroom session which involved problem-based learning (PBL) activities, table-top exercises, and a computerized simulation (Table 1). The modules were designed as a framework for a disaster medicine curriculum for undergraduates and covered the three main disciplines (clinical and psychosocial, public health, and emergency and risk management) of the core of "Disaster Health" according to the World Association for Disaster and Emergency Medicine (WADEM) international guidelines for disaster medicine education. From January 2011 through May 2013, 21 editions of the course were delivered to 21 different medical schools, and 524 students attended the course. The blended approach and the use of simulation tools were appreciated by all participants and successfully increased participants' knowledge of disaster medicine and basic competencies in performing mass-casualty triage. This manuscript reports on the designing process and the initial outcomes with respect to learners

  15. Two different stable low molecular weight RNA (LMW RNA) profiles within Sinorhizobium meliloti and within Sinorhizobium medicae

    Technology Transfer Automated Retrieval System (TEKTRAN)

    LMW RNA profiles of 179 isolates from Medicago, Melilotus and Trigonella species growing in a field site in northern Spain were analysed. Four different LMW RNA profiles designated I through IV were identified. Most of the isolates displayed either LMW RNA profile I or III (37 and 45%, respectively)...

  16. Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells.

    PubMed

    Efferth, Thomas; Kahl, Stefan; Paulus, Kerstin; Adams, Michael; Rauh, Rolf; Boechzelt, Herbert; Hao, Xiaojiang; Kaina, Bernd; Bauer, Rudolf

    2008-01-01

    The cure from cancer is still not a reality for all patients, which is mainly due to the limitations of chemotherapy (e.g., drug resistance and toxicity). Apart from the high-throughput screening of synthetic chemical libraries, natural products represent attractive alternatives for drug development. We have done a systematic bioactivity-based screening of natural products derived from medicinal plants used in traditional Chinese medicine. Plant extracts with growth-inhibitory activity against tumor cells have been fractionated by chromatographic techniques. We have isolated the bioactive compounds and elucidated the chemical structures by nuclear magnetic resonance and mass spectrometry. By this strategy, we identified 25-O-acetyl-23,24-dihydro-cucurbitacin F as a cytotoxic constituent of Quisqualis indica. Another promising compound identified by this approach was miltirone from Salvia miltiorrhiza. The IC50 values for miltirone of 60 National Cancer Institute cell lines were associated with the microarray-based expression of 9,706 genes. By COMPARE and hierarchical cluster analyses, candidate genes were identified, which significantly predicted sensitivity or resistance of cell lines to miltirone.

  17. Relationships between fasting plasma insulin, anthropometrics, and metabolic parameters in a very old healthy population. Associazione Medica Sabin.

    PubMed

    Carantoni, M; Zuliani, G; Volpato, S; Palmieri, E; Mezzetti, A; Vergnani, L; Fellin, R

    1998-05-01

    Several studies have shown that insulin resistance and hyperinsulinemia are associated with many metabolic disorders predisposing to coronary heart disease (CHD). This syndrome has been termed syndrome X. However, it is not completely known whether these relationships are still present in the elderly, or whether other factors such as age, gender, and body fat distribution modulate them. Therefore, we investigated the relationship between fasting plasma insulin, total and regional adiposity, fasting plasma glucose and lipids, plasma plasminogen activator inhibitor-1 (PAI-1), fibrinogen, and coagulation factor VII in a sample of 100 healthy free-living octogenarians-nonagenarians (52 men and 48 women) who were disability-free according to the Katz index. By univariate analysis, fasting insulin correlated positively with all anthropometric measures except the waist to hip ratio (WHR) in women. There was a positive correlation between fasting insulin and fasting glucose (r=.40, P < .01), plasma triglycerides ([TGs] r=.21, P < .05), and PAI-1 levels (r=.33, P < .01), whereas a negative relation was found with high-density lipoprotein cholesterol (HDL-C) and apolipoprotein, A-I (apo A-I) levels (r=-.22 and =-.24, respectively, P < .05). These relationships were weaker and less significant in women. In pooled data, stepwise multiple regression analysis showed an independent relationship of both the body mass index (BMI) and fasting insulin level with TGs (R2=.14), while gender and fasting insulin were the best predictors of HDL-C variance (R2=.17). Furthermore, fasting insulin was the only variable independently related to PAI-1 (R2=.12). Our findings support the existence of a metabolic syndrome even in very old age by showing that high insulin levels are related to various metabolic and hemostatic disorders.

  18. Outcomes of vital pulp therapy in permanent teeth with different medicaments based on review of the literature

    PubMed Central

    Akhlaghi, Najmeh; Khademi, Abbasali

    2015-01-01

    Vital pulp therapy (VPT) is a biologic and conservative treatment modality to preserve the vitality and function of the coronal or remaining radicular pulp tissue in vital permanent teeth. A search was conducted via the Cochrane database, PubMed, MEDLINE, and Ovid for any articles with the criteria for “pulp-capping,” or “pulp-capping materials” and “VPT outcomes” from 1978 to mid 2014. All articles were evaluated and the valid papers were selected. The outcomes of various VPT techniques, including indirect pulp treatment, direct pulp treatment, partial pulpotomy, and complete pulpotomy in vital permanent teeth were extracted. Although various studies have different research approach, most studies noted a favorable treatment outcome. Mineral trioxide aggregate (MTA) appears to be more effective than calcium hydroxide (Ca(OH)2) for maintaining long-term pulp vitality after indirect and direct pulp-capping. However, it seems that the success rate for partial pulpotomy and pulpotomy with Ca(OH)2 is similar to MTA. PMID:26604953

  19. Ions Release and pH of Calcium Hydroxide-, Chlorhexidine- and Bioactive Glass-Based Endodontic Medicaments.

    PubMed

    Carvalho, Ceci Nunes; Freire, Laila Gonzales; Carvalho, Alexandre Pinheiro Lima de; Duarte, Marco Antonio Húngaro; Bauer, José; Gavini, Giulio

    2016-01-01

    This study evaluated pH and release of calcium, sodium and phosphate ions from different medications in human dentin. Fifty premolars were prepared and randomly divided into groups: (CHX) - 2% chlorhexidine gel; (CHX + CH) - CHX + calcium hydroxide PA; (CH) - CH + propylene glycol 600; (NPBG) - experimental niobium phosphate bioactive glass + distilled water; (BG) - bioactive glass (Bio-Gran) + distilled water. The specimens were immersed in deionized water and the pH variations were measured. The quantification of ions in the solutions was made by inductively coupled plasma - atomic emission spectroscopy (ICP/AES) at 10 min, 24 h, 7, 14, 21 and 30 days. The results were analyzed by ANOVA and Tukey`s test, with a significance level of 5%. CH had the highest level of calcium ions release at 30 days, while CHX and BG released more sodium ions. BG, NPBG and CHX released a higher amount of phosphate ions. The pH of CH was significantly higher compared with the other groups. CH favored the greatest increase of pH and calcium ions release. The bioactive glasses released more sodium and phosphate ions and presented an alkaline pH immediately and after 30 days.

  20. [The struggle of early Christians against Isis medica: breaks and continuity in traditions in the context of health and healing].

    PubMed

    Moog, Ferdinand Peter

    2009-01-01

    The study of health and healing gods may offer significant examples of how certain ideas survive, with hardly any substantial loss, across periods of great change. It is no surprise that, following centuries of struggle by early Christians against the worship of pagan gods, some originally heathen ideas and elements of thinking should have been in due course, if with prudence, adapted to Christian needs and sensibilities. A most remarkable instance of such practice is to be found, somewhat surprisingly, in the life of the bishop St. Cyril of Alexandria. He opposed rigorously the cult of Isis, above all in Egypt, but nevertheless adapted features of Isis to his conception of the Blessed Virgin Mary as 'Theotokos'. In this manner Isis, the goddess-mother, with her child Horus became--in a certain measure--a type of the Blessed Virgin Mother of God, accompanied by the Infant Jesus. The legendary arson perpetrated at the start of the 6th century A.D. against a temple in Cologne wherein a healing deity was worshipped should, it is argued here for the first time, be understood in the context of conflict between early Christianity and the cult of Isis. There is good reason to believe that the aforementioned temple set on fire by Gallus, later Bishop of Clermont, was in fact the shrine of Isis in Cologne.

  1. Histological evaluation of the effect of three medicaments; trichloracetic acid, formocresol and mineral trioxide aggregate on pulpotomised teeth of dogs.

    PubMed

    Karami, Babak; Khayat, Akbar; Moazami, Fariborz; Pardis, Soheil; Abbott, Paul

    2009-04-01

    The aim of this study was to use clinical, radiographic and histological examinations to compare the dental pulp response in 162 premolar roots of eight dogs when trichloracetic acid (TCA), formocresol, mineral trioxide aggregate (MTA) and zinc oxide eugenol were used as pulpotomy agents. The teeth were divided into four groups. Following pulpotomy, the teeth were restored with amalgam. The animals were sacrificed at 48 h, 2, 4 and 8 weeks (two dogs at each interval). Histological evaluation indicated no cases with necrosis. After 8 weeks follow up, dentine bridge formation was evident in 20%, 50% and 91.7% of formocresol, TCA and MTA cases respectively. The first signs of bridge formation were seen for MTA at 2 weeks and for TCA at 4 weeks. MTA was superior to formocresol and TCA in treating pulps in dogs. However, bridge formation was seen in 50% of TCA cases after 8 weeks which is a desirable finding in pulpotomy procedures.

  2. [Contention on the theory of processing techniques of Chinese materia medica in the Ming-Qing period].

    PubMed

    Chen, Bin; Jia, Tianzhu

    2015-03-01

    On the basis of the golden stage of development of processing techniques of medicinals in the Song dynasty, the theory and techniques of processing in the Ming-Qing dynasties developed and accomplished further. The knowledge of some physicians on the processing of common medicinal, such as Radix rehmannia and Radixophiopogonis, was questioned, with new idea of processing methods put forward and argued against those insisting traditional ones, marking the progress of the art of processing. By reviewing the contention of technical theory of medicinal processing in the Ming-Qing period, useful references can be provided for the inheritance and development of the traditional art of processing medicinals.

  3. Retrievabilty of calcium hydroxide intracanal medicament with Chitosan from root canals: An in vitro CBCT volumetric analysis

    PubMed Central

    Vineeta, Nikhil; Gupta, Sachin; Chandra, Aditi

    2014-01-01

    Aim: This study compared the amount of aqueous-based and oil-based calcium hydroxide [Ca(OH)2 ] remaining in the canal, after removal with two different chelators 17% EDTA and 0.2% Chitosan in combination with ultrasonic agitation. Materials and Methods: Cleaning and shaping of root canals of 28 mandibular premolar was done and canals were filled either with Metapex or Ca(OH)2 mixed with distilled water. Volumetric analysis was performed utilizing cone beam-computed tomography (CBCT) after 7 days of incubation. Ca(OH)2 was removed using either 17% EDTA or 0.2% Chitosan in combination with ultrasonic agitation. Volumetric analysis was repeated and percentage difference was calculated and statistically analysed using Kruskal-Wallis and Mann-Whitney U test. Results: Both the chelators failed to remove aqueous-based as well as oil-based Ca(OH)2 completely from the root canal. Aqueous-based Ca(OH)2 was easier to be removed than oil-based Ca(OH)2. 0.2% Chitosan was significantly more effective for removal of oil-based Ca(OH)2 (P < 0.01) while both 17% EDTA and 0.2% Chitosan were equally effective in removing aqueous-based Ca(OH)2 . Conclusion: Combination of 0.2% Chitosan and ultrasonic agitation results in lower amount of Ca(OH)2 remnants than 17% EDTA irrespective of type of vehicle present in the mix. PMID:25298647

  4. Evaluation of Antimicrobial and Antifungal Efficacy of Inter Appointment Intracanal Medicaments against Enterococcus and Candida albicans: An In Vitro Study

    PubMed Central

    Gupta, Shubh Prabhat; Bhati, Manisha; Jhajharia, Kapil; Patel, Hardik; Paliwal, Ashutosh; Franklin, Sundeep

    2015-01-01

    Background: Microorganisms and their by-products in pulpal and periapical diseases are to be considered as the primary etiological agents of the pulpal necrosis and apical periodontitis. Enterococcus faecalis, which is the most common organism isolated from failed root canals, is a Gram-positive facultative anaerobe. Yeasts can be detected in 7-18% of infected root canals. Materials and Methods: Designed to evaluate the antimicrobial and antifungal efficacy of chlorhexidine gutta-percha (CHX-GP), and calcium hydroxide GP points against E. faecalis and Candida albicans. The test materials used are divided into 3 groups; Group A - Control, Regular GP, Group B – CHX-GP, Group C - Calcium hydroxide GP. Detail Method is explained in the article. Results: There was a significant difference in the inhibition of E. faecalis, in different materials at each time interval period (P < 0.05). Similarly, the inhibition of C. albicans in the different materials at each time period was found to be statistically significant (P < 0.05). Calcium hydroxide GP did not exhibit any antimicrobial effect on any of tested microorganisms for all the time periods. Conclusion: CHX-GP had the maximum effect on the test microorganisms, with the maximum efficacy on E. faecalis followed by C. albicans. Regular GP also had a significant efficacy on test microorganisms, with the maximum efficacy on E. faecalis followed by C. albicans. Calcium hydroxide GP did not have any effect on any test microorganisms during the entire test periods. PMID:26124609

  5. Medication for Military Aircrew: Current Use, Issues, and Strategies for Expanded Options (les medicaments pour les equipaes militaires: Consommation actuelle, questions et strategies pour des options elargies)

    DTIC Science & Technology

    2001-06-01

    such as isoproterenol have been superseded by relatively selective beta2 agonists including terbutaline, isoetharine, and albuterol ( salbutamol ...United States Air Force The United States Air Force (USAF) has used amphetamines and caffeine in support of air operations since the early 1960s... Amphetamine was used during the Vietnam War and during the air strike on Libya in 1986.3 During the campaign to liberate Kuwait it was used occasionally

  6. News at Biochemia Medica: research integrity corner, updated guidelines to authors, revised author statement form and adopted ICMJE Conflict-of-Interest Form.

    PubMed

    Simundic, Ana-Maria

    2013-01-01

    From the issue 23(1) we have implemented several major changes in the editorial policies and procedures. We hope that those changes will raise awareness of our potential authors and reviewers for research and publication integrity issues as well as to improve the quality of our submissions and published articles. Among those changes is the launch of a special journal section called Research Integrity Corner. In this section we aim to publish educational articles dealing with different research and publication misconduct issues. Moreover, we have done a comprehensive revision of our Instructions to authors. Whereas our former Instructions to authors have mostly been concerned with recommendations for manuscript preparation and submission, the revised document additionally describes the editorial procedure for all submitted articles and provides exact journal policies towards research integrity, authorship, copyright and conflict of interest. By putting these Guidelines into action, we hope that our main ethical policies and requirements are now visible and available to all our potential authors. We have also revised the former Authorship and copyright form which is now called the Author statement form. This form now contains statements on the authorship, originality of work, research ethics, patient privacy and confidentiality, and copyright transfer. Finally, Journal has adopted the ICMJE Form for Disclosure of Potential Conflicts of Interest. From this issue, for each submitted article, authors are requested to fill out the "ICMJE Form for Disclosure of Potential Conflicts of Interest" as well as the Author statement form and upload those forms during the online manuscript submission process. We honestly believe that our authors and readers will appreciate such endeavors. In this Editorial article we briefly explain the background and the nature of those recent major editorial changes.

  7. [Characteristics of women participating in the family planning program of the Direccion General de Atencion Medica Materna Infantil y Planificacion Familiar de la SSA].

    PubMed

    Correu Azcona, S; Cervantes, A; Campos, J; Keller, A

    1978-01-01

    It is evident that since the period 1973-4, some important changes have occurred with regard to the age, number of living children, and educational status of new acceptors within the family planning program of the Secretaria de Salubriad y Asistencia. While the 1973-4 acceptors were older, had more children, and had more education, the 1976 acceptors were younger, had less education, and had a number of children similar to the population at large. It is interesting to note that 1976 rural acceptors exhibit the same fertility levels as those acceptors of the 1973-4 urban programs, although as a whole, they are younger and less educated. It is possible that through the same legitimization process, accelerated by communication and motivation campaigns, it will shortly be possible for the rural program to recruit acceptors with fewer children. (author's modified)

  8. The Influence of Dentine on the pH of Calcium Hydroxide, Chlorhexidine Gel, and Experimental Bioactive Glass-Based Root Canal Medicament

    PubMed Central

    Nunes Carvalho, Ceci; Gonzales Freire, Laila; Pinheiro Lima de Carvalho, Alexandre; Luiz Siqueira, Evandro; Bauer, José; Cunha Gritti, Giovana; Pereira de Souza, Juliana; Gavini, Giulio

    2015-01-01

    Objectives. To evaluate the influence of dentine on the pH of different medications in standardized simulated canals. Materials and Methods. Forty resin blocks were divided into groups with and without dentine powder, as follows: 2% chlorhexidine gel; 2% chlorhexidine gel associated with calcium hydroxide PA; calcium hydroxide PA delivered in propylene glycol 600; and NPG delivered in distilled water. The dentine powder was obtained from the root dentine of bovine teeth and added to the medications. The simulated canals were placed in containers with 1.5 mL of deionized water and pH was monitored in multiple intervals, up to 30 days. The mean pH values were calculated and submitted to statistical analysis using paired Student's t-test and ANOVA complemented by the Tukey test (p < 0.05). Results. There was no statistical difference between the groups with and without dentine powder (p > 0.05). The pH values of calcium hydroxide were significantly higher than those of NPG in the first 24 hours (p < 0.05). After 7 days, both behaved in a similar manner. Conclusion. The addition of dentine powder to the medications evaluated did not alter the pH of the external solution in any of the time points tested. PMID:26347249

  9. Corrigendum to "Basin-scale controls on the molybdenum-isotope composition of seawater during Oceanic Anoxic Event 2 (Late Cretaceous)" [Geochim. Cosmochim. Acta 178 (2016) 291-306

    NASA Astrophysics Data System (ADS)

    Dickson, Alexander J.; Jenkyns, Hugh C.; Porcelli, Donald; van den Boorn, Sander; Idiz, Erdem; Owens, Jeremy D.

    2016-09-01

    A recent molybdenum-isotope estimate of the extent of anoxic and euxinic conditions in the world ocean during Oceanic Anoxic Event 2 (∼94 Ma) concluded by discussing a contrast between the new results with existing estimates of marine euxinia based on sulphur isotopes. This suggested contrast was erroneous; when areal extents of marine anoxia and euxinia are calculated for both isotopic proxies, the agreement is actually striking, and highlights the fact that large areas of the global ocean probably remained well ventilated during this event.

  10. Erratum to "A novel strategy for spectrophotometric simultaneous determination of amitriptyline and nortriptyline based on derivation with a quinonoid compound in serum samples" [Spectrochim. Acta A Mol. Biomol. Spectrosc. 168, 2016, 235-243

    NASA Astrophysics Data System (ADS)

    Farnoudiyan-Habibi, Amir; Massoumi, Bakhshali; Jaymand, Mehdi

    2017-04-01

    The authors regret that the surname of author Amir Farnoudiyan-Habibi was misspelt as Amir Farnoudian-Habibi. In addition, the affiliation for the author was incorrect and should have been ;Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, P.O. Box: 5157944533, Tabriz, Islamic Republic of Iran;.

  11. Western Hemisphere Conference on Persons with Disabilities. Conference Proceedings (Washington, D.C., March 14-18, 1993) = Conferencia Hemisferica Occidental sobre Personas con Discapacidades. Actas de la Conferencia. (Washington, D.C., 14 al 18 de Marzo de 1993).

    ERIC Educational Resources Information Center

    Kelley, Jerry D., Ed.; And Others

    This document presents the proceedings of a conference which brought together delegates and First Ladies representing western hemisphere nations to address needs and issues affecting people with disabilities in the Americas. It presents the texts of two keynote addresses: "Small Triumphs, Big Victories: A Global View of Persons with…

  12. Comments on "Synthesis aspects, structural, spectroscopic, antimicrobial and room temperature ferromagnetism of zinc iodide complex with Schiff based ligand" by K. Shakila and S. Kalainathan, Spectrochim. Acta 135 A (2015) 1059-1065

    NASA Astrophysics Data System (ADS)

    Srinivasan, Bikshandarkoil R.; Nadkarni, V. S.

    2016-06-01

    Shakila and Kalainathan report on the synthetic and structural aspects of a zinc iodide complex with Schiff based ligand, which exhibits room temperature ferromagnetism. In this comment, many points of criticism, concerning the characterization of this so called zinc iodide complex of Schiff based ligand are highlighted to prove that the title paper is completely erroneous.

  13. Corrigendum to "Historical review: Anders Jonas Ångström and the foundation of spectroscopy - Commemorative article on the second centenary of his birth" [Spectrochim. Acta Part B, 102 (2014) 12-23

    NASA Astrophysics Data System (ADS)

    Reif-Acherman, Simón

    2015-07-01

    The following addendum should be added to the Acknowledgments of the above article. Due to the multiplicity of simultaneous activities in which I am continuously involved, I forgot mentioning that Prof. Dr. Klaus Hentschel, of the History Department of the University of Stuttgart (Germany) was helpful in obtaining some of the source material used in my review. In particular, Prof. Hentschel provided the scans of Anne Beckmann's work to which I was guided by passages in his book on "Mapping the spectrum", Oxford University Press (2002). I also followed his recommendation of contacting the Swedish historians of science, and Prof. Sven Widmalm among them; however, the correspondence was not successful.

  14. Corrigendum to "Isotopic and geochemical characterization of fossil brines of the Cambrian Mt. Simon sandstone and Ironton-Galesville formation from the Illinois Basin, USA" [Geochim. Cosmochim. Acta 165 (2015) 342-360

    NASA Astrophysics Data System (ADS)

    Labotka, Dana M.; Panno, Samuel V.; Locke, Randall A.; Freiburg, Jared T.

    2016-08-01

    The original Fig. 4 incorrectly represented data from Clayton et al. (1966). The deuterium values were reported in percent deuterium and mistaken by the authors as per mille. The corrected Fig. 4 Corrigendum is given and shows the data from Clayton et al. (1966) plotting in a similar manner as other published data for groundwater in the Illinois Basin. The data from Clayton et al. (1966) was not used in the discussion of the deep-seated Cambrian brines, and, therefore, this misrepresentation does not affect the conclusions of the original manuscript. The authors apologize for the oversight.

  15. Corrigendum to ‘Evidence for shock heating and constraints on Martian surface temperatures revealed by 40Ar/39Ar thermochronometry of Martian meteorites’ [Geochim. Cosmochim. Acta (2010) 6900–6920

    DOE PAGES

    Cassata, William S.; Shuster, David L.; Renne, Paul R.; ...

    2014-10-23

    Here, the authors regret they have discovered errors in Eq. (3) and in a spreadsheet used to calculate cosmogenic exposure ages shown in Table 1. Eq. (3) is missing a term. The spreadsheet errors concerned an incorrect cell reference and application of Eq. (3). Correction of these errors results in ~15–20% changes to the exposure ages of all samples, minor (generally <0.2%) changes to the radioisotopic ages of some samples (those that entailed a correction for chlorine-derived 38Ar calculated based on the exposure age; see Section 3.3), and statistically insignificant changes to the inferred trapped components identified through isochron analyses.more » These modifications have no impact on the modeling, discussions, or conclusions in the paper, nor do the changes to radioisotopic ages exceed the 1 sigma uncertainties.« less

  16. Corrigendum to ‘Evidence for shock heating and constraints on Martian surface temperatures revealed by 40Ar/39Ar thermochronometry of Martian meteorites’ [Geochim. Cosmochim. Acta (2010) 6900–6920

    SciTech Connect

    Cassata, William S.; Shuster, David L.; Renne, Paul R.; Weiss, Benjamin P.

    2014-10-23

    Here, the authors regret they have discovered errors in Eq. (3) and in a spreadsheet used to calculate cosmogenic exposure ages shown in Table 1. Eq. (3) is missing a term. The spreadsheet errors concerned an incorrect cell reference and application of Eq. (3). Correction of these errors results in ~15–20% changes to the exposure ages of all samples, minor (generally <0.2%) changes to the radioisotopic ages of some samples (those that entailed a correction for chlorine-derived 38Ar calculated based on the exposure age; see Section 3.3), and statistically insignificant changes to the inferred trapped components identified through isochron analyses. These modifications have no impact on the modeling, discussions, or conclusions in the paper, nor do the changes to radioisotopic ages exceed the 1 sigma uncertainties.

  17. Actas de la 4th mesa redonda sobre investigacion en "Lenguas Extranjeras" en la Universidad Autonoma Metropolitana 1996. (Proceedings from the 4th Roundtable on Investigation in Foreign Languages in the Autonomous Metropolitan University 1996).

    ERIC Educational Resources Information Center

    Zoreda, Margaret Lee, Comp.; Diop, Mamoudou Si, Comp.; Vivaldo Lima, Javier, Comp.

    The articles included in this volume were selected as exemplary papers from the conference in Mexico. The goal of the forum was to provide an opportunity for researchers from the three branches of the Universidad Autonoma Metropolitana (UAM) to meet and discuss research projects currently in progress at the university. The works presented here…

  18. Corrigendum to 'Evidence for shock heating and constraints on Martian surface temperatures revealed by 40Ar/39Ar thermochronometry of Martian meteorites' [Geochim. Cosmochim. Acta (2010) 6900-6920

    NASA Astrophysics Data System (ADS)

    Cassata, William S.; Shuster, David L.; Renne, Paul R.; Weiss, Benjamin P.

    2015-01-01

    The authors regret they have discovered errors in Eq. (3) and in a spreadsheet used to calculate cosmogenic exposure ages shown in Table 1. Eq. (3) is missing a term. The spreadsheet errors concerned an incorrect cell reference and application of Eq. (3). Correction of these errors results in ∼15-20% changes to the exposure ages of all samples, minor (generally <0.2%) changes to the radioisotopic ages of some samples (those that entailed a correction for chlorine-derived 38Ar calculated based on the exposure age; see Section 3.3), and statistically insignificant changes to the inferred trapped components identified through isochron analyses. These modifications have no impact on the modeling, discussions, or conclusions in the paper, nor do the changes to radioisotopic ages exceed the 1 sigma uncertainties.

  19. Reply to "Methane origin in the Samail ophiolite: Comment on 'Modern water/rock reactions in Oman hyperalkaline peridotite aquifers and implications for microbial habitability'" [Geochim. Cosmochim. Acta 179 (2016) 217-241

    NASA Astrophysics Data System (ADS)

    Miller, Hannah M.; Matter, Jürg M.; Kelemen, Peter; Ellison, Eric T.; Conrad, Mark; Fierer, Noah; Ruchala, Tyler; Tominaga, Masako; Templeton, Alexis S.

    2017-01-01

    We thank Dr. Giuseppe Etiope for his comment and the opportunity to further discuss why we consider the origin of the methane detected in subsurface fluids obtained from a peridotite aquifer in Oman to be enigmatic.

  20. Methane origin in the Samail ophiolite: Comment on "Modern water/rock reactions in Oman hyperalkaline peridotite aquifers and implications for microbial habitability" [Geochim. Cosmochim. Acta 179 (2016) 217-241

    NASA Astrophysics Data System (ADS)

    Etiope, Giuseppe

    2017-01-01

    Miller et al. (2016) report a new study of fluids in the peridotites of the Samail ophiolite in Oman related to modern serpentinization (olivine hydration), a process that can provide energy and raw materials for chemosynthetic microbial life. The authors, in particular, report an isotopic composition for methane (CH4) in groundwater near Ibra (up to 1.4 mM) that is unusually 13C-enriched (δ13CCH4 ∼ +2.4 and +3‰ VPDB), and consider the gas origin to be uncertain, i.e., abiotic or microbial, and to be modulated by significant fractionation due to oxidation or diffusion. The purpose of this comment is to clarify and correct a few points concerning the possible origin of the δ13CCH4 values, with the intention to promote a fruitful and constructive debate, considering the interest that there is for serpentinization and the associated formation of various gases.

  1. Coping with Social Change: Programs That Work. Proceedings of a Conference (Acapulco, Mexico, June 1989) = Como enfrentarse al cambio social: programas eficaces. Actas de uno Conferencia (Acapulco, Mexico, Junio de 1989).

    ERIC Educational Resources Information Center

    Hoskins, Irene, Ed.

    Written in English and Spanish, this document contains the proceedings of the 14th International Congress of Gerontology on concerns about the impact of rapid social change on the well-being of older women and families in Latin American and the Caribbean and about effective programs that address the needs of the older populations. The first…

  2. Corrigendum to "Synthesis and spectral characterization of new homologous 1,3,5-triaryl-2-pyrazolines: Influence of alkyloxy chain length on fluorescence" [Spectrochim. Acta Part A: Mol. Biomol. Spectrosc. 133 (2014) 182-189

    NASA Astrophysics Data System (ADS)

    Abbas, Asghar; Hussain, Safdar; Hafeez, Noureen; Naseer, Muhammad Moazzam

    2015-03-01

    The authors regret to inform that the affiliation of one of the authors, namely, Noureen Hafeez has been written as Department of Forensic Medicine & Toxicology, Rawalpindi Institute of Health Sciences (RIHS), Bahria University, Islamabad, Pakistan in the published article. The correct address is shown above.

  3. Comment on "Assessment of new DFT methods for predicting vibrational spectra and structure of cisplatin: Which density functional should we choose for studying platinum(II) complexes?" [Spectrochim. Acta A125 (2014) 431-439

    NASA Astrophysics Data System (ADS)

    Marques, Maria Paula M.; Batista de Carvalho, Luis A. E.; Parker, Stewart F.

    2015-02-01

    As researchers in the field of Pt(II) and Pd(II) compounds as potential anticancer agents, we were surprised by the recent paper by Malik and Michalska (hereafter MM) on the application of DFT methods to cisplatin

  4. WITHDRAWN: Corrigendum to "High-sensitive cardiac troponin I (hs-cTnl) values in patients with stable cardiovascular disease: An initial foray" [Clinica Chimica Acta 411 (2010) 812--817].

    PubMed

    Schulz, Olaf; Reinicke, Markus; Berghoefer, Gunnar H; Bensch, Ricarda; Kraemer, Jochen; Schimke, Ingolf; Jaffe, Allan S

    2010-05-18

    This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

  5. Comment on "Behavior of Re and Os during contact between an aqueous solution and oil: Consequences for the application of the Re-Os geochronometer to petroleum" [Geochim. Cosmochim. Acta 158 (2015) 1-21

    NASA Astrophysics Data System (ADS)

    Wu, Jia; Li, Zhen; Wang, Xuan-ce

    2016-08-01

    In a recent study, Mahdaoui et al. (2015) simulated the contact of oil with Re/Os-bearing aqueous fluids in petroleum reservoirs and concluded that both metals could be rapidly and substantially enriched in the oil fraction. These findings could have significant geological ramifications for the use of rhenium-osmium (Re-Os) geochronology in the age-dating of oil deposits. However, the lack of data reproducibility between parallel experiments and misused parameter of "recovery rate" has cast doubt on the main conclusions of the paper. Re-analyses of the raw data provided sufficient evidence to suggest that in petroleum basins with very low abundances of Re and Os, the extraction of these metals to oil is unlikely to be a geologically instantaneous process as the authors implied in their study. In addition, the possibility of reactor leakage in the contacting experiments cannot be completely ruled out.

  6. Corrigendum to "Recycling of crustal material by the Iceland mantle plume: New evidence from nitrogen elemental and isotope systematics of subglacial basalts" [Geochim. Cosmochim. Acta 176 (2016) 206-226

    NASA Astrophysics Data System (ADS)

    Halldórsson, Sæmundur A.; Hilton, David R.; Barry, Peter H.; Füri, Evelyn; Grönvold, Karl

    2016-08-01

    In Table 1 of the above published paper, N2/40Ar* ratios (column 13) are incorrect. A corrected table and updated figures (Figs. 6-8) are shown below. The correct N2/40Ar* values vary between 178 and 2.6 × 104, with a mean of 4.1 ± 2.1 (×103). Although this range in N2/40Ar* ratios is somewhat smaller compared to what was reported, it still displays considerably more heterogeneity compared to the DMM database. The new mean value is also significantly higher than the DMM mean (138 ± 65), as discussed. Therefore, the findings in the paper concerning heterogeneous and elevated N2/40Ar* ratios in Icelandic subglacial basalts still stand.

  7. Corrigendum to "Pharmaceutical analysis in solids using front face fluorescence spectroscopy and multivariate calibration with matrix correction by piecewise direct standardization" [Spectrochim. Acta Part A: Mol. Biomol. Spectrosc. 103 (2013) 311-318

    NASA Astrophysics Data System (ADS)

    Alves, Julio Cesar L.; Poppi, Ronei J.

    2014-03-01

    The authors regret to inform that the tick labels of the ternary diagram axes in Fig. 1 were shown from 0% to 1.0% instead of 0% to 100%. The correct values of 0% to 100% are shown in the corrected Fig. 1 (see below). The right contents of the active ingredients in the sample sets shown in the diagram are now in agreement with the stated throughout the paper.

  8. Derechos Educacionales de los Padres: Una Explicacion de los Procedimientos de Seguridad para los Padres de Ninos con Discapacidades. Bajo la Clausula del Acta de Educacion para Individuos con Discapacidades (IDEA) y las Reglas para la Administracion del Acta de Educacion para Ninos Excepcionales (Educational Rights of Parents: An Explanation of Procedural Safeguards Available to Parents of Children with Disabilities. Under Provisions of the Individuals with Disabilities Education Act (IDEA) and the Rules for the Administration of the Exceptional Children's Educational Act [ECEA]).

    ERIC Educational Resources Information Center

    Mountain Plains Regional Resource Center, Des Moines, IA.

    This pamphlet, in Spanish, describes Colorado parents' educational rights under federal and state special education rules and regulations. It addresses: (1) free appropriate public education and termination of services; (2) required prior notice to parents if there is a proposed change or refusal to change a child's special education program; (3)…

  9. Conference on Applications of Artificial Neural Networks and Related Technologies to Manpower, Personnel, and Training

    DTIC Science & Technology

    1993-08-01

    34 unpublished Ph.D. Dissertation, Erasmus Universiteit Rotterdam, Centrum voor Wiskunde en Informatica . Wahba, G. [1984]: "Cross-Validated Spline Methods for...identification purposes. Biochemical systems such as genetic testing are being increasingly used for forensic testing, but are not yet practical as an applied

  10. High Resolution Radar Clutter Analysis and Modeling for Advanced Target Detection Strategies

    DTIC Science & Technology

    2007-11-01

    UNIVERSITÀ DI PISA DIPARTIMENTO DI INGEGNERIA DELL’INFORMAZIONE ELETTRONICA, INFORMATICA, TELECOMUNICAZIONI ANALYSIS OF THE...Muralidhar Rangaswamy* *collaborating engineer from the Air Force Research Laboratory Pisa , November 2007 REPORT DOCUMENTATION...University of Pisa Via Caruso, 14 Pisa 56122 Italy 8. PERFORMING ORGANIZATION REPORT NUMBER N/A 10. SPONSOR/MONITOR’S ACRONYM(S

  11. Safety, Immunogenicity and Lot Stability of the Whole Cell/Recombinant B Subunit (WC/rCTB) Cholera Vaccine in Peruvian Adults and Children

    DTIC Science & Technology

    1999-01-01

    Lima, Peru; Department of Medical Microbiology and Immunology, University of Göteborg, Göteborg, Sweden; Division of Communicable Diseases and...Romulo Puga, Proyectos en Informatica. Salud, Medicina y Agricultura, Lima, Peru. Ann- Mari Svenncrholm. Department of Medical Microbiology and Im

  12. Computer Education in the Vocational Teacher Training Centre at Eindhoven.

    ERIC Educational Resources Information Center

    Houben, J. W. M. A.; Verbunt, J. A.

    1985-01-01

    Teachers from The Netherland's 26 higher technical colleges in need of a teaching qualification (called an "informatica") were able to obtain it by in-service training, organized and offered by universities. Types of courses offered and policy describing information technology activities to be developed in the country by 1989 are…

  13. Informacion Bibliografica: Ano 3, Num. 9, Enero-Febrero, 1972 (Bibliographic Information: Volume 3, Number 9, January-February 1972).

    ERIC Educational Resources Information Center

    Martinez Martinez, Antonio L., Ed.

    This bulletin contains several articles on various topics concerning information science. The first article is a report on the November 1971 Seminar on Documentation and Pedagogical Information in Latin America held in Panama. The second article, entitled "Informatica," provides a discussion of information science by three Soviet writers;…

  14. European Scientific Notes. Volume 38. Number 1.

    DTIC Science & Technology

    1984-01-01

    software Dipartimento di Informatica e engineering, knowledge engineering, " 9 Sistemistica, Via Eudossiana 18, artificial intelligence , and pattern 00184...graph- support software development and the ics, and patterns, and for artificial architecture of the machines. The intelligence --including inference...Application programs using Figure 4. Hardware configuration of sophisticated techniques cf artificial PSI. intelligence will f nable natural lan

  15. From the Sierra to the Cities: The Urban Campaign of the Shining Path

    DTIC Science & Technology

    1992-01-01

    from the Institute Nacional de Estadistica y Informatica (INEI), Peru: Producto bruto interno regional, 1970-1988, Lima, 1990; INEI, Peru: Compendia...over the past five to ten years. 23Estimates derived from INEI, Peru: Producto bruto and Peru: Compendia esta· dlstico. 51 supply, which is

  16. Device Discovery in Frequency Hopping Wireless Ad Hoc Networks

    DTIC Science & Technology

    2004-09-01

    Thesis, Blekinge Institute of Technology, Available: http://www.inst-informatica.pt/v20/cid/ biblioteca digital /telecomunicacoes...Single-Channel Ground And Airborne Radio System,” Available: http://www.fas.org/man/dod-101/sys/land/docs/sincgars.pdf, 1996. Skl01. B. Sklar, Digital

  17. Nations Hospitable to Organized Crime and Terrorism

    DTIC Science & Technology

    2003-10-01

    http://www.inegi.gob.mx/ estadistica /espanol/sociodem/gobernacion/gob_04.html> 656 George W. Grayson, Mexico’s Forgotten Southern Border (Washington...Other Extremist Groups. Washington, D.C.: Federal Research Division, Library of Congress, 2002. Instituto Nacional de Estadistica , Geografia e...Informatica. Estadisticas Sociodemograficas, Atencion y Control de Indocumentados, 2002 [Sociodemographic Statistics: Illegal Alien Processing and

  18. Campylobacter Antimicrobial Resistance in Peru: A Ten-year Observational Study

    DTIC Science & Technology

    2012-08-16

    Veterinaria , Universidad de San Marcos, San Marcos, Peru Abstract Background Campylobacter jejuni and Campylobacter coli are food-borne pathogens of...2004, 10(6):1056–1063. 18. Nacional C: Instituto Nacional de Estadistica e Informatica. Lima: Segundo Edicion; 2008. 19. Patrick RM, Baron EJ

  19. A Calculus of Macro-Events: Progress Report

    DTIC Science & Technology

    2000-01-01

    1410, USA iliano@itd.nrl.navy.mil Angelo Montanari Dipartimento di Matematica e Informatica Universita di Udine Via delle Scienze, 206 { 33100 Udine...nition of ECTD-structure only by the following points: M MT is a set of macro-events over T . The codomain of [jji and hjj] are rede ned to be

  20. [Exploration of Yu Shen-chu's achievements in pharmacology and his academic idea].

    PubMed

    Hua, Bi-Chun

    2003-01-01

    Prof. Yu not only explored the origin of Chinese materia medica and its development, but also emphasized the education and popularization of Chinese, materia medica. He was arduous in practicing, summarizing, and writing of Chinese material medica and devoted all his life to the development and ducation of TCM. He was conversant with both TCM and Chinese pharmacology.

  1. Developing a validated liquid chromatography-mass spectrometric method for the simultaneous analysis of five bioactive quassinoid markers for the standardization of manufactured batches of Eurycoma longifolia Jack extract as antimalarial medicaments.

    PubMed

    Teh, Chin-Hoe; Murugaiyah, Vikneswaran; Chan, Kit-Lam

    2011-04-08

    An extensive comparative study on the electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) mass spectrometry using automated flow injection analysis (FIA), was performed on eurycomanone (1), 13α(21)-epoxyeurycomanone (2), eurycomanol (3), eurycomanol-2-O-β-d-glucopyranoside (4), and 13,21-dihydroeurycomanone (5), the bioactive markers isolated from Eurycoma longifolia. The effects of eluent mixture (methanol or acetonitrile in water) and acidic modifiers (acetic acid, formic acid and trifluoroacetic acid) on the ionization efficiency of the markers were also investigated. The ESI in the positive ion mode with methanol containing 0.1% (v/v) acetic acid was selected for the subsequent optimization of nebulizer pressure, dry gas flow, dry gas temperature and capillary voltage to improve the sensitivity of the total ion chromatogram (TIC). Fragmentation of the analytes was further investigated by varying the capillary exit offset voltage and fragmentation amplitude in positive mode of ESI. The detection limits (LODs) were determined in isolation mode (selected ion monitoring, SIM). Their limits of detection (LODs) ranged between 0.03 and 0.1μgmL(-1) while the intra-day and inter-day precisions were less than 5.72% and 4.82%, respectively. The method was next applied for the simultaneous analysis of the markers to standardize various batches of manufactured extracts of E. longifolia for potential use as antimalarial products. Multiple Reaction Monitoring (MRM) mode was used for the quantification of analytes which gave protonated molecular ion, [M+H](+). For those without pseudo-molecular ions, SIM mode was used to quantify the analytes. The batches contained 5.65-9.95% of eurycomanone (1), 5.21-19.75% of eurycomanol (3) and 7.59-19.95% of eurycomanol-2-O-β-d-glucopyranoside (4) as major quassinoids whereas, 13α(21)-epoxyeurycomanone (2), and 13,21-dihydroeurycomanone (5) were much lower in concentrations of 0.78-3.90% and 0.47-1.76%, respectively.

  2. La Seccion de Investigacion sobre Educacion Medica de la Facultad de Medicina de la Universidad National Autonoma de Mexico (The Medical Education Investigation Section of the School of Medicine of UNAM).

    ERIC Educational Resources Information Center

    Campillo Sainz, Carlos; Alvarez, Tostado, Juan

    This document is an English-language abstract (approximately 1,500 words) of a survey of Mexican medical education needs for the future. To plan for these needs, SISEM of UNAM was formed with the objectives of carrying out and promoting investigations in the different areas of medical education. It also wants to distribute the information…

  3. [Deciphering the argots of the names of materia medica and its dosage in the Yi lin kou pu liu zhi mi shu (A Secret Medical Book of Six Therapies in Rhymes of Medical Professionals)].

    PubMed

    Zhou, Jian; Lin, Shiyi; Liu, Shijue

    2014-11-01

    Yi lin kou pu liu zhi mi shu (A Secret Medical Book of Six Therapies in Rhymes of Medical Professionals) was additionally compiled, supplemented and annotated by Zhou Sheng, a famous doctor of the Qing Dynasty, based on Yi lin kou pu (Rhymes of Medical Professionals) which was composed by Lu Qi. The book contains four volumes in total, dealing mainly with the miscellaneous diseases of internal medicine, as well as external medicine, gynecology, and pediatrics etc. The syndrome differentiation and treatment, prescriptions and medications in this book has its own characteristic with rather high academic value and practical significance. There were 20 drug names were deciphered by the argots, for instance, "you che" was the argot of golden thread, and "wu yue (May)" was the argot of medicinal evodia fruit, etc. In addition, the argots were often used to decipher numerals and quantifiers, for example, "su, qi, zi, qi, man" referring to 1, 2, 3, 4, 5 respectively, and "huo, pu, xiang, feng, lai" referring to 6, 7, 8, 9, 10 respectively, and "qing","zhong","xi" referring to qian, liang and fen respectively. Hence, deciphering of these argots could help to understand and apply these prescriptions correctly.

  4. Reconstruction of the inventory of materia medica used by members of the Jewish community of medieval Cairo according to prescriptions found in the Taylor-Schechter Genizah collection, Cambridge.

    PubMed

    Lev, Efraim; Amar, Zohar

    2006-12-06

    The Taylor-Schechter (T-S) collection at Cambridge University Library is the biggest of all Cairo Genizah collections in the world. The importance and the potential of research into the medical aspects of the Genizah documents were clear to researcher since the early 1960s. A few works have been published since, usually focusing on one subject, or even important single manuscripts. The current research concerned mainly with one aspect of the history of medicine of the Jewish community of Cairo (as a reflection of Eastern medieval societies), namely the practical uses of natural substances for medicine. The most interesting and original information is undoubtedly to be found in the 141 prescriptions, as they reflect the medical reality that actually existed. And indeed, 242 substances were recorded in the prescriptions identified: 195 substances of plants origin (80.6%), 27 inorganic materials (11.2%) and 20 substances of animal origin (8.2%) were recorded as being in practical used for medicinal purposes. The most frequently mentioned substances were the rose, myrobalan, sugar, almonds, and endive. The most prevalent ailments: eye diseases, headache, constipations (purgative), cough, skin diseases, stomach, fever, gynaecological problems, haemorrhoids, liver ailments, lice, swellings, dental trouble, ulcers, and problems of the urinary tract.

  5. Flameless Atomic Absorption Spectroscopy: Effects of Nitrates and Sulfates.

    DTIC Science & Technology

    1980-05-01

    oxide by graphite followed by sublimation of the metal. Frech and Cedergren investigated high temperature equilibria in graphite furnace atomizers. 1 4...Acta, 72, 49 (1974). 13. R.E. Sturgeon, C.L. Chakrabarti, and C.H. Langford, Anal. Chem., 48, 1792 (1976). 14. W. Frech and A. Cedergren , Anal. Chim...Acta, 82, 83 (1976). 15. W. Frech, Anal. Chim. Acta, 77, 43 (1975). 16. W. Frech and A. Cedergren , Anal. Chim. Acta, 88, 57 (1977). CHAPTER III

  6. Adaptive continuous twisting algorithm

    NASA Astrophysics Data System (ADS)

    Moreno, Jaime A.; Negrete, Daniel Y.; Torres-González, Victor; Fridman, Leonid

    2016-09-01

    In this paper, an adaptive continuous twisting algorithm (ACTA) is presented. For double integrator, ACTA produces a continuous control signal ensuring finite time convergence of the states to zero. Moreover, the control signal generated by ACTA compensates the Lipschitz perturbation in finite time, i.e. its value converges to the opposite value of the perturbation. ACTA also keeps its convergence properties, even in the case that the upper bound of the derivative of the perturbation exists, but it is unknown.

  7. The Behaviors that College Students Classify as Political Bias: Preliminary Findings and Implications

    ERIC Educational Resources Information Center

    Tollini, Craig

    2009-01-01

    There have been a number of recently published books and reports about the existence of a liberal bias in academia (e.g., ACTA 2005, ACTA 2006, Berube 2006, Black 2004, Horowitz 2006, Horowitz 2008, and Shapiro 2004). Sociology is one of the disciplines that is most frequently cited as "producers" of bias in two of these studies (ACTA 2006,…

  8. Guia del Proceso del IFSP de Colorado: Conexiones para la Ninez Temprana, Iniciativa Infantil de Colorado Parte C del Acta de Educacion para Individuos con Desabilidades (Colorado Guidelines for the IFSP Process: Early Childhood Connections, Colorado's Infant/Toddler Initiative for Part C of the Individuals with Disabilities Education Act).

    ERIC Educational Resources Information Center

    Miller, Jerri; Petersen, Sandy

    This booklet for Spanish-speaking parents of young children with disabilities describes Colorado's Individualized Family Service Plan (IFSP) process. It explains guidelines, shares family stories and reflections for families and care providers, and the describes the values that drive the IFSP process in Colorado. Information is provided on…

  9. Comment on "Structural and vibrational studies on 1-(5-Methyl- [1,3,4] thiadiazol-2-yl)-pyrolidin-2-ol" [Spectrochimica Acta Part A, 152 (2016) 252-261]. The importance of intramolecular OH ⋯ N hydrogen bonding in the conformational properties of thiadiazol-pyrrolidin-2-ol bearing species

    NASA Astrophysics Data System (ADS)

    Laurella, Sergio L.; Erben, Mauricio F.

    2016-07-01

    The title paper [1] reports a study on the spectroscopic and physicochemical properties of 1-(5-methyl- [1,3,4]thiadiazol-2-yl)-pyrrolidin-2-ol (MTPN) based on experimental and theoretical data. The latter ones are based on the computed molecular structure for a rather unusual conformer. Here, after a careful analysis of the conformational space of MTPN, the most stable conformation was determined for the molecule isolated in a vacuum, which results to be 21.9 kJ/mol more stable than the conformer reported previously. Our study also includes the closely related species 1-(5-trifluoromethyl- [1,3,4]thiadiazol-2-yl)-pyrrolidin-2-ol (FMTPN). An intramolecular OH ⋯ N hydrogen bond determines the conformational behavior of the [1,3,4]thiadiazol-2-yl)-pyrrolidin-2-ol group as demonstrated by Natural Bond Orbital population analysis.

  10. Comment on "Structural and vibrational studies on 1-(5-Methyl- [1,3,4] thiadiazol-2-yl)-pyrolidin-2-ol" [Spectrochimica Acta Part A, 152 (2016) 252-261]. The importance of intramolecular OH⋯N hydrogen bonding in the conformational properties of thiadiazol-pyrrolidin-2-ol bearing species.

    PubMed

    Laurella, Sergio L; Erben, Mauricio F

    2016-07-05

    The title paper [1] reports a study on the spectroscopic and physicochemical properties of 1-(5-methyl- [1,3,4]thiadiazol-2-yl)-pyrrolidin-2-ol (MTPN) based on experimental and theoretical data. The latter ones are based on the computed molecular structure for a rather unusual conformer. Here, after a careful analysis of the conformational space of MTPN, the most stable conformation was determined for the molecule isolated in a vacuum, which results to be 21.9kJ/mol more stable than the conformer reported previously. Our study also includes the closely related species 1-(5-trifluoromethyl- [1,3,4]thiadiazol-2-yl)-pyrrolidin-2-ol (FMTPN). An intramolecular OH⋯N hydrogen bond determines the conformational behavior of the [1,3,4]thiadiazol-2-yl)-pyrrolidin-2-ol group as demonstrated by Natural Bond Orbital population analysis.

  11. Reply to the comment by Wu et al. (2016) on "Behavior of Re and Os during contact between an aqueous solution and oil: Consequences for the application of the Re-Os geochronometer to petroleum" [Geochim. Cosmochim. Acta 158 (2015) 1-21

    NASA Astrophysics Data System (ADS)

    Reisberg, Laurie; Michels, Raymond; Mahdaoui, Fatima

    2016-08-01

    We reply here to the questions raised by Wu et al. concerning the results published by Mahdaoui et al. (2015). This paper describes experiments in which aqueous solutions containing ReO4- and OsCl62- were brought in contact with natural oils at various ranges of concentration, time and temperature. The main observation is that the transfer of Re and Os to oils is very efficient under all experimental conditions. Wu et al. argue that thermodynamic equilibrium was not achieved in these experiments as apparent partition coefficients are inconsistent. They conclude that the experiments were flawed by possible leaking of reactors and that the conclusions by Mahdaoui et al. (2015) were not justified. In the following reply we explain that Mahdaoui et al. (2015) never claimed that thermodynamic equilibrium was achieved. Any calculations or considerations in this context are therefore meaningless. We recall the objectives of our publication, which were to experimentally test the behavior of ReO4- and OsCl6- (two plausible chemical forms of Re and Os in deep aquifers of petroleum systems) in aqueous solution-oil systems. To our knowledge these are the first experiments of their kind. The parameters that could influence the precision and reproducibility of our results were discussed in detail in Mahdaoui et al. (2015). The essential point is that all 60 of the experiments provide evidence of substantial transfer of Re and Os from water to oil. In contrast to what was mistakenly understood by Wu et al., the paper does not challenge the use of Re-Os to date geological events affecting petroleum. Instead, by providing a mechanism that might allow Os isotopic homogenization on a basin-wide scale, a critical step missing from most current models, it offers a possible explanation of how Re-Os geochronology in oils could potentially work. More generally, our study suggests that transfer of Re and Os from waters to oil may be an important phenomenon that should not be overlooked.

  12. [Behind the naming of herbal section as the decoction section in Treasured Mirror Of Eastern Medicine].

    PubMed

    Oh, Chaekun

    2011-12-31

    Heo Jun, who is the main compiler of Treasured Mirror of Eastern Medicine, states to applicate Shennong's Classic of Materia Medica, Rihuazi's annotations and Li Gao and Zhu Zhenheng's opinion to arrange materia medica on the introductory notes of Treasured Mirror of Eastern Medicine. While Shennong's Classic of Materia Medica and Rihuazi's annotations are both conventional texts dealing with materia medica, Li Gao and Zhu Zhenheng are just clinical practitioners. Not only Li Gao has no authorship on materia medica, but also Zhu Zhenheng's Supplement to the Elucidation of Materia Medica is assessed to have no distinctive achievements. Nevertheless, Heo Jun shows positive considerations for their achievements of materia medica. Specifically, on the Decoction Section in Treasured Mirror of Eastern Medicine, theories of lift, lower, float, sink and Channel Entry, both representative achievements of Yishui school-including Li Gao-are adopted as it is, and Zhu Zhenheng's expressions are frequently utilized for conclusive remarks of medicinal effect. Furthermore, applications of both clinicians can be found within nature & flavour which is one of the principal terms of understanding materia medica. While being based on the conventional materia medica text Classified Emergency Materia Medica, the Decoction section in Treasured Mirror of Eastern Medicine is not restrained by the intricate traditional compositions and shows a new aspect of depiction by adding clinical information. And I think it is a important meaning of the Decoction section, which is the herbal chapter of Treasured Mirror of Eastern Medicine.

  13. [Research of Zhanbra Dorje's contribution on the development of Mongolian medicine].

    PubMed

    Bao, Ha-shen

    2010-01-01

    Zhanbra Dorje, a famous Mongolian physician, is one of the top ten Mongolian scientists. He firstly presented the illustrations for 561 kinds of Mongolian materia medica in his book, Classic Canon of Mongolian Materia Medica, which was greatly helpful to the recognition, collection, using, learning, research and identification of Mongolian materia medica. In this book, he annotated the name of Mongolian materia medica by four kinds of languages, which contributed significantly to the academic and cultural exchanges among Mongolian, Tibetan, Han and Manchu medicine. He also cleared up the confusion of the name of Mongolian materia medica, which led to the irrational use of materia medica, and improved the qualities and clinical effects of Mongolian patent medicine. In addition, he pointed out 82 acu-points and their locations for moxibustion with relevant indications, which promoted actively to the maturity and systematization of Mongolian traditional therapeutics.

  14. [The effect of food intake on drug action].

    PubMed

    Pletscher, W; Peretti, E

    1990-01-01

    Interactions between medicaments and food are only incompletely documented--despite their frequent occurrence. Food can influence the effect of medicaments in a variety of ways: the effect of the medicament can be delayed or weakened; in some cases the effect may also be increased. The interactions between the kinetics of medicaments and food are described in the present survey. The absorption conditions in the stomach and small intestine are influenced physiologically and chemically by food. In very rare cases the elimination of active ingredients too can be modified by the quality and quantity of the food. Detailed knowledge about the physical-chemical properties of the medicaments used help to optimize the pharmacotherapy in the individual case. For the patient, the easiest suggestion to follow would be to take the medicaments with plenty of water and always at the same time.

  15. The Spanish National Reference Database for Ionizing Radiations (BANDRRI)

    PubMed

    Los Arcos JM; Bailador; Gonzalez; Gonzalez; Gorostiza; Ortiz; Sanchez; Shaw; Williart

    2000-03-01

    The Spanish National Reference Database for Ionizing Radiations (BANDRRI) is being implemented by a reasearch team in the frame of a joint project between CIEMAT (Unidad de Metrologia de Radiaciones Ionizantes and Direccion de Informatica) and the Universidad Nacional de Educacion a Distancia (UNED, Departamento de Mecanica y Departamento de Fisica de Materiales). This paper presents the main objectives of BANDRRI, its dynamic and relational data base structure, interactive Web accessibility and its main radionuclide-related contents at this moment.

  16. NAFTA Effects on Income Inequality between 1998 and 2006: A Comparative Analysis

    DTIC Science & Technology

    2013-12-01

    ANALYSIS 5. FUNDING NUMBERS 6. AUTHOR(S) Celil Aybar 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Postgraduate School Monterey, CA...INTERNATIONAL LABOUR ORGANIZATION IMF INTERNATIONAL MONETARY FUND INEGI INSTITUTO NACIONAL DE ESTADISTICA, GEOGRAFIA E INFORMATICA NAAEC NORTH...In the way of finding an answer to the research question, the first part (Chapters I and II) of the thesis will include the definition of income

  17. PRISMATIC: Unified Hierarchical Probabilistic Verification Tool

    DTIC Science & Technology

    2011-09-01

    M. Hiserote 19b. TELEPHONE NUMBER (Include Area Code) (937) 255-2252 Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std. Z39-18 i ...developed two variants: ( i ) learning minimum consistent partition and (ii) learning minimum state separating automata. We have implemented the algorithms...H., Hahn, E.M., Wachter , B., and Zhang, L., “Time-bounded Model Checking of Infinite-state Continuous-time Markov Chains,” Fundamenta Informaticae

  18. Bone-97 Alcohol and Skeletal Adaptation to Mechanical Usage

    DTIC Science & Technology

    2002-10-01

    Revista Medica de Chile 124:423, 1996. 41. Schnitzler CM and Solomon L. S...postmenopausal estrogen therapy on bone density without evidence of liver damage. Revista Medica de Chile 124:423-430. in elderly women. N Engl J Med 329:1141...Lillo R, Bustamante E (1996) Assessment of bone status in intermittent and continuous alcoholics, without evidence of liver damage. Revista Medica de Chile

  19. Biosignal alterations generated by parabolic flights of small aerobatic aircrafts

    NASA Astrophysics Data System (ADS)

    Simon, M. Jose; Perez-Poch, Antoni; Ruiz, Xavier; Gavalda, Fina; Saez, Nuria

    characteristics of the aerobatic parabolic flights are different from the ones corresponding to the big Airbus-300 of Novespace-CNES-ESA aircraft. In this case, the two episodes of hypergravity reach 1.8g for 3 seconds with 20-25 seconds of low gravity in between whereas the small aerobatic plane reaches 3g level during roughly 2.5 seconds and 8 seconds period of low gravity. This means that the present potential alterations of the human body are more aggressive but also faster. [1] Y. Kawai, M. Doi, A. Setogawa, R. Shimoyama, K. Ueda, Y. Asai, K. Tatebayashi, Effects of Microgravity on Cerebral Hemodynamics, Yonago Acta Medica, 46 (2003) 1-8. [2] E.A.I. Aidu, V.G. Trunov, L.I. Titomir, A. Capderou, P. Vaïda, Transformation of Vectorcardiogram Due to Gravitation Alteration, Measurement, Science Review, 3 (2003) 29-32. [3] R.J. Von Baumgarten, G. Baldrighi, G.L. Schillinger, O. Harth, R. Thuemler, Vestibular function in the space environment, Acta Astronautica, 2 (1975) 49-58. [4] http://reversiblefigures.blogspot.com.es/p/outreach.html

  20. Actin isoform specificity is required for the maintenance of lactation

    PubMed Central

    Weymouth, Nate; Shi, Zengdun; Rockey, Don C.

    2014-01-01

    Smooth muscle α-actin (Acta2) is one of six highly conserved mammalian actin isoforms that appear to exhibit functional redundancy. Nonetheless, we have postulated a specific functional role for the smooth muscle specific isoform. Here, we show that Acta2 deficient mice have a remarkable mammary phenotype such that dams lacking Acta2 are unable to nurse their offspring effectively. The phenotype was rescued in cross fostering experiments with wild type mice, excluding a developmental defect in Acta2 null pups. The mechanism for the underlying phenotype is due to myoepithelial dysfunction postpartum resulting in precocious involution. Further, we demonstrate a specific defect in myoepithelial cell contractility in Acta2 null mammary glands, despite normal expression of cytoplasmic actins. We conclude that Acta2 specifically mediates myoepithelial cell contraction during lactation and that this actin isoform therefore exhibits functional specificity. PMID:22123032

  1. China Report, Science and Technology, No. 188

    DTIC Science & Technology

    1983-02-18

    PHYSICS DIWEN WULI [ACTA PHYSICA TEMPERATURAE HUMILIS SINICA], No 4, 1982 ...................................................... 13 THERMOPHYSIC S...Epoxy Resin" SOURCE: Beijing DIWEN WULI [ACTA PHYSICA TEMPERATURAE HUMILIS SINICA] in Chinese No 4, 1982 pp 284-290 TEXT OF ENGLISH ABSTRACT: A...34Investigations of Model JWL-150A Superconducting Magnet Power Supply and SCR Automatic Protection System" SOURCE: Beijing DIWEN WULI [ACTA PHYSICA TEMPERATURAE

  2. JPRS Report, Science & Technology. China: Stealth/Counter-Stealth Research.

    DTIC Science & Technology

    1992-11-19

    Frequency-Selective Surfaces 92FE0801F Beijing DIANZIXUEBAO [ACTA ELECTRONICA SINICA] in Chinese Vol 20 No 6, Jun 92 pp 85-88 [Article by Shen...microwave devices and electromag- netic scattering. Motion Compensation Method in ISAR Imaging 92FE0801A Beijing DIANZIXUEBAO [ACTA ELECTRONICA ...Chinese Society of Electronics and an editor of DIANZI XUEBAO [ACTA ELECTRONICA SINICA]. Deng Wenbiao Born in February 1961, he graduated from the

  3. Resonance Scattering Analysis by Autoregressive Models Applied to Air-Filled, Cylindrical, Thin Walled Shells in Water

    DTIC Science & Technology

    1997-10-01

    plane wave by a circular cylindrical shell. Results of computations. Acustica - Acta Acustica , 82, 1996: 689-697. [5] de Billy M., Determination of the...circumferential waves on cylindrical elastic shells. Acustica - Acta Acustica , 82, 1996: 707-716. [14] Bhattacharyya G.K., and Johnson R.A., Statistical...22] Batard H, Talmant M., and Quentin G.J., The Acoustical Characteristics Estimation Method (MECA) applied to cylinders and shells. Acta Acustica

  4. Outdoor Sound Propagation Modelling in Complex Environments: Recent Developments in the Parabolic Equation Method

    DTIC Science & Technology

    2006-10-01

    equation for sound waves in inhomogeneous moving media”, Acustica united with Acta Acustica , Vol 83(3), pp 455-460,1997. [3] L. Dallois, Ph. Blanc...propagation in a turbulent atmosphere within the parabolic approximation”, Acustica united with Acta Acustica , Vol 87(1), pp 659-669, 2001 [6] M. Karweit...approaches", Acta Acustica united with Acustica , 89 (6), 980-991, (2003). [40] Ph. Voisin, Ph. Blanc-Benon, "The influence of meteorological

  5. Spatial Hearing in Echoic Environments

    DTIC Science & Technology

    2008-02-29

    target from masker and thereby support selective attention. (Published in 2005 in Acta Acustica united with Acustica [J3]) A paper was published...localization. (Published in 2008 in Acta Acustica united with Acustica [J10]) Interest in the perceptual consequences of reverberation on perception...E Larson and Satyavarta (2005). “Top-down and bottom-up influences on spatial unmasking,” Acta Acustica united with Acustica . [J4] Naka, Y, A

  6. Creativity and Democratic Governance. Adult Learning: A Strategic Choice. Proceedings of the ICAE World Assembly (6th, Ocho Rios, Jamaica, August 9-12, 2001) = Creativite et Gouvernance Democratique. L'apprentissage des Adultes: Un Choix Strategique. Actes de la Assemblee Mondiale du CIEA (6th, Ocho Rios, Jamaique, 9 au 12 aout 2001) = Creatividad y Gobernabilidad Democratica. Educacion de Adultos: Una Eleccion Estrategica. Actas de la Asamblea Mundial del ICAE (6th, Ocho Rios, Jamaica, Agosto 9-12, 2001).

    ERIC Educational Resources Information Center

    Dobson, Stephan, Ed.

    This document contains information from and about a world assembly on creativity and democratic governance in adult learning that was held by the International Council for Adult Education (ICAE) and its partner organizations in the Caribbean. The proceedings begin with English, French, and Spanish translations of the address…

  7. US Army Medical Bioengineering Research and Development Laboratory Annual Progress Report for FY 84. Volume 1

    DTIC Science & Technology

    2015-12-24

    being considered for chemical hardening of equipment, a Thermoelectric Field Refrigerator, a newly marketed Rescue Stretcher, and a Modified...WARFARE MEDICAMENTS Objective: To determine, by market search, the best method/appliance to contain and deliver chemical warfare medicaments. Military...Feasibility studies have been conducted to determine the most efficient motors and compressors available on the market . The product- improved nozzle

  8. Redescription of the Holotype of Culex (Culex) Peus Speiser and Taxonomy of Culex (Culex) Stigmatosoma Dyar and Thriambus Dyar (Diptera: Culicidae)

    DTIC Science & Technology

    1988-10-12

    Publica, Boletines T&r& cos, Serie A: Entomologia Medica y Parasitologia No. 1. 66 pp. Matheson, R. 1944. Handbook of the Mosquitoes of North America...Ver- teneuil, Brussels. 257 pp. + 5 pls. Forattini, 0. P. 1965. Entomologia Medica . 2” Vol- ume_ Editora da Universidade de Sao Paulo. 506 PP

  9. Advances in membrane protein crystallography: in situ and in meso data collection

    SciTech Connect

    Weyand, Simone; Tate, Christopher G.

    2015-05-23

    Membrane protein structural biology has made tremendous advances over the last decade but there are still many challenges associated with crystallization, data collection and structure determination. Two independent groups, Axford et al. [(2015), Acta Cryst. D71, 1228–1237] and Huang et al. [(2015), Acta Cryst. D71, 1238–1256], have published methods that make a major contribution to addressing these challenges.

  10. Interactions and Binding Energies of Dimethyl Methylphosphonate and Dimethyl Chlorophosphate with Amorphous Silica

    DTIC Science & Technology

    2012-07-10

    Phys. 2007, 127, 184708. (17) Palmero, A.; Aldao, C. M. Readsorption and Diffusion-Limited TPD of Water from Zeolite Linde 4A. Thermochim. Acta 1998...319, 177−184. (18) Palmero, A.; Loffler, D. G. Kinetics of Water Desorption from Pelletized 4A and 5A Zeolites . Thermochim. Acta 1990, 159, 171−176

  11. Wave Propagation in Granular Media Including Marine Sediments

    DTIC Science & Technology

    2002-09-30

    the latter were present at all). Our preliminary findings have been reported in papers published in Acta Acustica , the Journal of Computational...underwater acoustics experiments”, Acta Acustica , in press. 19. M. J. Buckingham, E. M. Giddens, J. B. Pompa, F. Simonet and T. R. Hahn, “A light

  12. Auditory and Cross-Modal Spatial Attention

    DTIC Science & Technology

    2007-01-01

    interaural level and interaural envelope timing (weak cues for left-right direction). This work, published in Acustica united with Acta Acustica in... Acta Acust united Acustica 2005; 91:967-9. Durlach NI, Mason CR, Gallun FJ, Shinn-Cunningham BG, Colburn HS, and Kidd G Jr. Informational masking for

  13. Emergence of the Green’s Functions from Noise and Passive Acoustic Remote Sensing of Ocean Dynamics

    DTIC Science & Technology

    2010-09-30

    environments, Acta Acustica united with Acustica , 95, no. 6, p. 963–974 (2009b) [published, refereed] O. A. Godin, Emergence of deterministic Green’s...Godin, Emergence of acoustic Green’s functions from time averages of ambient noise, Acta Acustica united with Acustica (2010) [in press, refereed

  14. Real Time Urban Acoustics Using Commerical Technologies

    DTIC Science & Technology

    2011-08-01

    situations with a non-refracting atmosphere: Model based on analytical solutions for diffraction and reflection. Acustica — Acta Acustica 1997;83:436...by hard sound barriers and seamounts.’ [20] E. Salomons, 1997 ACTA ACUSTICA , 83, 436-454, ’Sound propagation in complex outdoor situations with a

  15. Leading the Charge: Governors, Higher Education and Accountability

    ERIC Educational Resources Information Center

    American Council of Trustees and Alumni, 2014

    2014-01-01

    With this new tool, ACTA [American Council of Trustees and Alumni] is working to expand its outreach to governors nationwide on behalf of higher education reform, focusing on key issues of quality, cost, and accountability. ACTA has worked with governors and education leaders from across the country, and that experience has proven that innovative…

  16. USSR Report, Life Sciences Biomedical and Behavioral Sciences.

    DTIC Science & Technology

    2007-11-02

    Pharmacological College, Niigata, Japan [Abstract] Following research that described Rickettsia rickettsii and R. prowazekii, using an electron...of Mice Fibroblasts Infected With Rickettsia Tsutsugamushi (T. Tsuruhara, et al.; ACTA VIROLOGICA, No 6, Nov 82) 13 Some Clinical...Russian, 13 Western. [230-12131] SURFACE MORPHOLOGY OF MICE FIBROBIASTS INFECTED WITH RICKETTSIA TSUTSUGAMUSHI Bratislava’ACTA VIROLOGICA in Russian

  17. The Vanishing Shakespeare: A Report by the American Council of Trustees and Alumni

    ERIC Educational Resources Information Center

    Neal, Anne D.; Mitchell, Charles

    2007-01-01

    As this report goes to press, the nation's capital is in the midst of a six-moth, city-wide celebration of William Shakespeare. With this celebration as a backdrop, the American Council of Trustees and Alumni (ACTA) researched how Shakespeare fits into English curricula at 70 of the nation's leading colleges and universities. ACTA surveyed English…

  18. The Effect of an Experimental Missile Wound to the Brain on Brain Electrolytes, Regional Cerebral Blood Flow and Blood Brain Barrier Permeability.

    DTIC Science & Technology

    1987-02-10

    13:59-64, 1980 @@ - -.q e SO86 17. Anden N-E, Dahlstrom A, Fuxe K, et al: Functional role of the nigro-striatal dopamine neurons. Acta Pharmac Tox 24...Acta Physiol Scand Suppl 367:69-93, 1971 19. Anden N-E: Effect of amphetamine and some other drugs on central catecholamine mechanisms, in Costa E

  19. Visual Distinctness Determined by Partially Invariant Features

    DTIC Science & Technology

    2000-03-01

    DISTINCTNESS DETERMINED BY PARTIALLY INVARIANT FEATURES. J.A. Garcia, J. Fdez-Valdivia Departamento de Ciencias de la Computacion e I.A. Univ. de Granada...E.T.S. de Ingenieria Informatica. 18071 Granada. Spain E-mail: jagsadecsai.ugr.es, J.Fdez-Valdivia@decsai.ugr.es Xose R. Fdez-Vidal Departamento de... Fisica Aplicada. Univ. de Santiago de Compostela. Facultad de Fisica . 15706 Santiago de Compostela. Spain E-mail: faxose@usc.es Rosa Rodriguez-Sanchez

  20. [The registration of deaths in Venezuela: an evaluation of coverage].

    PubMed

    Bidegain, G; Lopez, D

    1987-08-01

    "This paper presents six indirect techniques for estimating the degree of death coverage as applied to vital statistics information in Venezuela between 1960 and 1982, collected by two public institutions, namely, the 'Oficina Central de Estadistica e Informatica' (OCEI) and the Ministry of Health and Social Assistance (MSAS).... The results show remarkable improvements in the death registry coverage for both institutions, that amount to 97 or 98 per cent at the beginning of the 80's. Nevertheless, great differences can be observed between them regarding both structure and volume of deaths by sex and age." Among the problems discussed are the impact of immigration and errors in age reporting. (SUMMARY IN ENG)

  1. [Interactions between herbal medicines and drugs].

    PubMed

    Tůmová, L

    2000-07-01

    At present the use of medicaments of plant origin is on the increase. It is therefore necessary to take into consideration that there exist known as well as potential interactions between the medicament of the medicinal plant. The problematic plants include Echinacea, Allium cepa, Gingko biloba, Panax ginseng, as well as Hypericum perforatum, Valeriana officinalis, or Glycyrrhiza glabra. Its use should be limited, or completely excluded in the cases of simultaneous therapy with, e.g., warfarin, hepatotoxically acting medicaments, MAOI inhibitors, phenelzin sulphate, or phenytoin, as they may decrease of completely eliminate the therapeutic effect of the administered drugs, or they may cause a toxic damage to the organism.

  2. 77 FR 23807 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-20

    ..., Col. Roma, Zapopan, Jalisco, Mexico; Blvd. Puerta de Hierro No 6094, Zapopan, Jalisco, Mexico; Paseo...- 583093 (Panama) DISTRIBUIDORA MEDICA HOSPITALARIA, S.A. DE C.V., Colima No. 323 Int. 9, Col. Roma...

  3. The Screening and Evaluation of Experimental Antiparasitic Drugs

    DTIC Science & Technology

    1990-09-27

    Oil Sources Exhibiting Antimalarial Activity in Vitamin E-Deficient Mice. 1989. IX Congreso Latinoamericano de Parasitologia . Caracas, Venezuela. A...Peroxidized Fish Oil. XIIth International Congress for Tropical Medicine and Malaria. Amsterdam, The Netherlands. Excepta Medica . International

  4. [Non steroidal anti-inflammatory drugs and rheumatic diseases].

    PubMed

    Cossermelli, W; Pastor, E H

    1995-01-01

    Nonsteroidal anti-inflammatory drugs (NSAID) comprise an important class of medicaments that reduced the symptoms of inflamation in rheumatic disease. This article emphasizes similarities and class characteristics of the NSAID, mechanisms of action, and drug-interactions.

  5. Implantable drug therapy device: A concept

    NASA Technical Reports Server (NTRS)

    Feldstein, C.

    1972-01-01

    Design is described of small, rechargeable, implantable infusor which contains fluid medicament stored under pressure and which dispenses fluid continuously through catheter. Body of infusor is covered by pliable silicone rubber sheath attached to suture pad for securing device.

  6. 77 FR 3774 - Sunshine Act Meeting Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-25

    ... Health System, Inc. Docket 9346. ] Portion Closed to the Public (2) Executive Session to follow Oral Argument in ProMedica Health System, Inc., Docket 9346. CONTACT PERSON FOR MORE INFORMATION: Mitch...

  7. The crucial role of Activin A on the formation of primordial germ cell-like cells from skin-derived stem cells in vitro.

    PubMed

    Sun, Rui; Sun, Yuan-Chao; Ge, Wei; Tan, Hui; Cheng, Shun-Feng; Yin, Shen; Sun, Xiao-Feng; Li, Lan; Dyce, Paul; Li, Julang; Yang, Xiao; Shi, Qing-Hua; Shen, Wei

    2015-01-01

    Primordial germ cells (PGCs) are founder cells of the germ cell lineage, and can be differentiated from stem cells in an induced system in vitro. However, the induction conditions need to be optimized in order to improve the differentiation efficiency. Activin A (ActA) is a member of the TGF-β super family and plays an important role in oogenesis and folliculogenesis. In the present study, we found that ActA promoted PGC-like cells (PGCLCs) formation from mouse skin-derived stem cells (SDSCs) in both embryoid body-like structure (EBLS) differentiation and the co-culture stage in a dose dependent manner. ActA treatment (100 ng/ml) during EBLS differentiation stage and further co-cultured for 6 days without ActA significantly increased PGCLCs from 53.2% to 82.8%, and as well as EBLS differentiation without ActA followed by co-cultured with 100 ng/ml ActA for 4 to 12 days with the percentage of PGCLCs increasing markedly in vitro. Moreover, mice treated with ActA at 100 ng/kg body weight from embryonic day (E) 5.5-12.5 led to more PGCs formation. However, the stimulating effects of ActA were interrupted by Smad3 RNAi, and in an in vitro cultured Smad3(-/-) mouse skin cells scenario. SMAD3 is thus likely a key effecter molecule in the ActA signaling pathway. In addition, we found that the expression of some epiblast cell markers, Fgf5, Dnmt3a, Dnmt3b and Wnt3, was increased in EBLSs cultured for 4 days or PGCLCs co-cultured for 12 days with ActA treatment. Interestingly, at 16 days of differentiation, the percentage of PGCLCs was decreased in the presence of ActA, but the expression of meiosis-relative genes, such as Stra8, Dmc1, Sycp3 and Sycp1, was increased. In conclusion, our data here demonstrated that ActA can promote PGCLC formation from SDSCs in vitro, at early stages of differentiation, and affect meiotic initiation of PGCLCs in later stages.

  8. Solid Electrolytes: Alkali-Ion Transport in Skeleton Structures

    DTIC Science & Technology

    1975-12-31

    Hagman and P. Kierkegaard , Acta Chem. Scand. 2_2, 1822 (1968). R.G. Sizova, A.A. Voronkov. N.G. Shomyatskaga. V.V. Pynkhin and N V Belov...Subsequently it was w learned that Hagman and Kierkegaard (6) had reported the structure of NaZr2P3012. With the same space group, they...Dokl. Akad. Nauk SSSR. Ser. 205, Issue 1. 90 (1972). 5 H.Y-P. Hong, Acta. Cryst. B30, 468 (1974). 6. L. Hagman and P. Kierkegaard , Acta. Chem

  9. Prediction of Molecular Properties.

    DTIC Science & Technology

    1987-08-01

    21. Cobbledick, R.E. and Small, R.W.H., Acta Cryst, Vol. B30, p. 1918, 1974. 22. Filhol, A., Bravic, G., Rey-Lafon, M., and Thomas , M., Acta Cryst...Mortimer, C.T., Quincey , P.G., and Springall, H.D., J Chem Soc, p. 958, 1958. 27. Captain Michael Coolidge was of great assisstance in completing the...Bravic, G., Rey-Lafon, M.. and Thomas , M., Acta Cryst, Vol. B36, p. 575, 1980. 205/206 APPENDIX B The following file is the VAX DCL command file that

  10. Marginal Leakage of a Softened Temporary Restoration as Determined by Microorganism Penetration.

    DTIC Science & Technology

    1980-03-31

    intracanal medicaments into the oral cavity. Intermediate Restorative Material , IRM , basically zinc oxide reinforced with a polymer resin mixed with eugenol...of a 2% aniline dye; however, neither study evaluated IRM . Marosky and associates2 studied temporary sealing 2 materials by using calcium chloride 45Ca...softening of IRM caused by a medicament would allow penetration by a specific highly motile microorganism (Proteus vulgaris.) 12 METHODS AND MATERIALS

  11. ["Revista Médica de Chile": 120 years (July 1872-July 1992)].

    PubMed

    Costa-Casaretto, C

    1992-07-01

    The "Revista Medica de Chile" founded in 1872 is the second oldest medical journal in Latin America after the "Gaceta Medica de Mexico" (1864). Among medical journals in the world it is placed 24. It has been published monthly without interruption, except for the period January through December 1891, due to the revolution taking place at that time. The first Editor was German Schneider, a German physician from Bonn who came to Chile in 1850 with the immigrants that settled in the South.

  12. Genetics Home Reference: familial thoracic aortic aneurysm and dissection

    MedlinePlus

    ... the arteries to maintain their shape instead of stretching out as blood is pumped through them. ACTA2 ... the sarcomeres' ability to prevent the arteries from stretching. The aorta, where the force of blood pumped ...

  13. Genetics Home Reference: myosin storage myopathy

    MedlinePlus

    ... proteins accumulate in type I skeletal muscle fibers, forming the protein clumps characteristic of the disorder. It ... Epub 2007 Mar 2. Citation on PubMed Tajsharghi H, Oldfors A. Myosinopathies: pathology and mechanisms. Acta Neuropathol. ...

  14. Genetics Home Reference: Bowen-Conradi syndrome

    MedlinePlus

    ... protein that is involved in the production of cellular structures called ribosomes , which process the cell's genetic instructions ... 8. Citation on PubMed Sondalle SB, Baserga SJ. Human diseases of the SSU processome. Biochim Biophys Acta. ...

  15. Bedside calculation of hemodynamic parameters with a hand held programmable calculator. Part II: Programs for hemodynamic and oxygen transport parameters computation.

    PubMed

    Laurent, M

    1980-01-01

    Two programs calculating oxygen transport parameters and hemodynamic values respectively are described. They may be used indifferently with HP 67 or HP 97 Hewlett Packard calculators. (Acta anaesth. belg., 1980, 31, 53-59).

  16. Genetics Home Reference: hyperphosphatemic familial tumoral calcinosis

    MedlinePlus

    ... regulation of phosphate levels within the body (phosphate homeostasis). Among its many functions, phosphate plays a critical ... of O-glycosylation in the maintenance of phosphate homeostasis. Biochim Biophys Acta. 2009 Sep;1792(9):847- ...

  17. Genetics Home Reference: Miller-Dieker syndrome

    MedlinePlus

    ... Pizzardi G, Del Balzo F, Iannetti P. Neuronal migration disorders: clinical, neuroradiologic and genetics aspects. Acta Paediatr. ... A. 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for ...

  18. USING BIOMONITORING DATA TO INFORM EXPOSURE ASSESSMENT IN CHILDREN

    EPA Science Inventory

    Discussing the challenges associated with estimating and interpreting toxicant exposures and health risks from biomonitoring data. Extended abstract will also be translated in Spanish and published in Acta Toxicologica Argentina.

  19. VISIÓN GENERAL DE LA EVALUACIÓN DEL RIESGO EN SALUD INFANTIL EMPLEANDO UN ENFOQUE POR ETAPAS DE DESARROLLO (American translation is: Overview of a Life Stage Approach to Children's Health Risk Assessment)

    EPA Science Inventory

    Discussing the challenges associated with estimating and interpreting toxicant exposures and health risks from biomonitoring data. This extended abstract was translated in Spanish and published in Acta Toxicologica Argentina.

  20. Uso de los Datos de Biomonitoreo para Informar sobre la Evaluacion Infantil (American translation is: USING BIOMONITORING DATA TO INFORM EXPOSURE ASSESSMENT IN CHILDREN)

    EPA Science Inventory

    Discussing the challenges associated with estimating and interpreting toxicant exposures and health risks from biomonitoring data. This extended abstract was translated in Spanish and published in Acta Toxicologica Argentina.

  1. Genetics Home Reference: aspartylglucosaminuria

    MedlinePlus

    ... This Page Aronson NN Jr. Aspartylglycosaminuria: biochemistry and molecular biology. Biochim Biophys Acta. 1999 Oct 8;1455(2-3):139-54. Review. Citation on PubMed Arvio MA, ... L. Molecular pathogenesis of a disease: structural consequences of aspartylglucosaminuria ...

  2. 76 FR 6683 - Information Related to Risks and Benefits of Powdered Gloves; Request for Comments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-07

    ..., 2003. 2. Malinger, G., S. Ginath, L. Zeidel, et al., ``Starch Peritonitis Outbreak After Introduction of a New Brand of Starch Powdered Latex Gloves,'' Acta Obstetricia et Gynecologica Scandinavica,...

  3. 2-D and 3-D Digital Analysis of Breast Calcifications: A Technique to Improve Mammographic Specificity

    DTIC Science & Technology

    2001-06-01

    the Institute of Laboratory Resources, national Research Council (NIH Publication No. 86-23, Revised 1985). X For the protection of human subjects...193-200, 1983. 23 Sigfusson BF, Andersson I, Aspegren K, et al. Clustered breast calcifications. Acta Radiologica 24: 273-281, 1983. September 19...the breast. Clin Radiol 34:193-200, 1983. 23. Sigfusson BF, Andersson I, Aspegren K, et al. Clustered breast calcifications. Acta Radiologica 24: 273

  4. Cellular and Tissue Injury During Nonfreezing Cold Injury and Frostbite

    DTIC Science & Technology

    1993-09-30

    membranes and is believed to interact primarily with the bulk solvent properties of water on a colligative basis. PVPs, due to their high molecular weights...phase transitions on the selective permeability properties of liposomes. Biochim. Biophys. Acta 406, 423-433 (1975). I 8. Bowers, Jr., W.D., Hubbard...The effects of chain length and lipid phase tiansitions on the selective permeability properties of 3 liposomes. Biochim. Biophys. Acta 406: 187-196. I

  5. A Method for the Analysis of Tabun in Multisol Using Gas Chromatographic Flame Photometric Detection

    DTIC Science & Technology

    2006-05-01

    ethoxy-phosphoryl cyanide (Tabun), Acta Chim.Scand. 1953; 7: 306-314. 12. Holmstedt B. Synthesis and pharmacology of dimethylamido-ethoxy-phosphoryl... cyanide (Tabun). Acta Chim. Scand. 1951, Suppl. No. 90, Stockholm, half-lives taken from figure 2, p 35. 13. Desire B, Saint-Andre, S...Anticonvulsant treatment of nerve agent seizures: anticholinergics vs diazepam in soman- intoxicated guinea pigs. Epilepsy Research 2000; 38: 1-14. 19

  6. Triazolam - Performance Side Effects: Vestibular, Musculoskeletal, and Complex Performance Tests.

    DTIC Science & Technology

    1987-03-04

    nitrazepam 5 mg with triazolam 0.5 mg in young psychiatric insomniac inpatients. Acta Psychiatrica Scandinavica, 62:519-524. 9. Borbely A. A., Loepfe...Kullingsjo H. 1982. Comparison of nitrazepam with triazolam in insomniac out-patients. Acta Psychiatrica Scandinavica, 65:86-92. 17. Damos D. L. 1985. The...1981. Triazolam compared with nitrazepam and with oxazepam in insomnia: Two double-blind crossover studies analyzed sequentially. British Journal of

  7. Activin A accelerates the progression of fetal oocytes throughout meiosis and early oogenesis in the mouse.

    PubMed

    Liang, Gui-Jin; Zhang, Xi-Feng; Wang, Jun-Jie; Sun, Yuan-Chao; Sun, Xiao-Feng; Cheng, Shun-Feng; Li, Lan; De Felici, Massimo; Shen, Wei

    2015-10-15

    Activins can exert several roles in ovary development. However, little is known about their involvement in early mammalian oogenesis. In this study, we reported that activin receptors (including ActRIA, ActRIB, ActRIIA, and ActRIIB) are expressed throughout the development of the mouse ovaries from 12.5 days postcoitum (dpc) to 21 days postparturition (dpp). Moreover, we found that in vitro, the addition of activin A (ActA) to the culture medium of 12.5 dpc ovarian tissues accelerated the progression of oocytes throughout meiotic prophase I stages. This result was reproduced in vivo following administration of ActA to pregnant mice. The in vitro effect of ActA was associated with increased expression of premeiotic and meiotic genes (including Dazl, Spo11, Stra8, Scp3, and Rec8) in the ovarian tissues. Mechanistically, ActA-dependent SMAD3 signaling modulated the expression of members of the retinoic acid (RA) system, including the RA degradation CYP26B1 enzyme and the RA receptors. Finally, ActA promoted the survival and growth of fetal and early postnatal oocytes and primordial follicle assembly both in vitro and in vivo. In conclusion, the present study identifies new roles of ActA in early oogenesis and suggested that ActA and RA might cooperate in promoting meiosis in female germ cells.

  8. Pharmacological interactions of vasoconstrictors.

    PubMed

    Gómez-Moreno, Gerardo; Guardia, Javier; Cutando, Antonio; Calvo-Guirado, José Luis

    2009-01-01

    This article is the first of a series on pharmacological interactions involving medicaments commonly prescribed and/or used in odontology: vasoconstrictors in local anaesthetics and anti-inflammatory and anti-microbial analgesics. The necessity for the odontologist to be aware of adverse reactions as a result of the pharmacological interactions is due to the increase in medicament consumption by the general population. There is a demographic change with greater life expectancy and patients have increased chronic health problems and therefore have increased medicament intake. The presence of adrenaline (epinephrine) and other vasoconstrictors in local odontological anaesthetics is beneficial in relation to the duration and depth of anaesthesia and reduces bleeding and systemic toxicity of the local anaesthetic. However, it might produce pharmacological interactions between the injected vasoconstrictors and the local anaesthetic and adrenergic medicament administered exogenically which the odontologist should be aware of, especially because of the risk of consequent adverse reactions. Therefore the importance of conducting a detailed clinical history of the general state of health and include all medicaments, legal as well as illegal, taken by the patient.

  9. Smooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-β

    PubMed Central

    Papke, Christina L.; Cao, Jiumei; Kwartler, Callie S.; Villamizar, Carlos; Byanova, Katerina L.; Lim, Soon-Mi; Sreenivasappa, Harini; Fischer, Grant; Pham, John; Rees, Meredith; Wang, Miranda; Chaponnier, Christine; Gabbiani, Giulio; Khakoo, Aarif Y.; Chandra, Joya; Trache, Andreea; Zimmer, Warren; Milewicz, Dianna M.

    2013-01-01

    Mutations in ACTA2, encoding the smooth muscle cell (SMC)-specific isoform of α-actin (α-SMA), cause thoracic aortic aneurysms and dissections and occlusive vascular diseases, including early onset coronary artery disease and stroke. We have shown that occlusive arterial lesions in patients with heterozygous ACTA2 missense mutations show increased numbers of medial or neointimal SMCs. The contribution of SMC hyperplasia to these vascular diseases and the pathways responsible for linking disruption of α-SMA filaments to hyperplasia are unknown. Here, we show that the loss of Acta2 in mice recapitulates the SMC hyperplasia observed in ACTA2 mutant SMCs and determine the cellular pathways responsible for SMC hyperplasia. Acta2−/− mice showed increased neointimal formation following vascular injury in vivo, and SMCs explanted from these mice demonstrated increased proliferation and migration. Loss of α-SMA induced hyperplasia through focal adhesion (FA) rearrangement, FA kinase activation, re-localization of p53 from the nucleus to the cytoplasm and increased expression and ligand-independent activation of platelet-derived growth factor receptor beta (Pdgfr-β). Disruption of α-SMA in wild-type SMCs also induced similar cellular changes. Imatinib mesylate inhibited Pdgfr-β activation and Acta2−/− SMC proliferation in vitro and neointimal formation with vascular injury in vivo. Loss of α-SMA leads to SMC hyperplasia in vivo and in vitro through a mechanism involving FAK, p53 and Pdgfr-β, supporting the hypothesis that SMC hyperplasia contributes to occlusive lesions in patients with ACTA2 missense mutations. PMID:23591991

  10. Smooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-β.

    PubMed

    Papke, Christina L; Cao, Jiumei; Kwartler, Callie S; Villamizar, Carlos; Byanova, Katerina L; Lim, Soon-Mi; Sreenivasappa, Harini; Fischer, Grant; Pham, John; Rees, Meredith; Wang, Miranda; Chaponnier, Christine; Gabbiani, Giulio; Khakoo, Aarif Y; Chandra, Joya; Trache, Andreea; Zimmer, Warren; Milewicz, Dianna M

    2013-08-01

    Mutations in ACTA2, encoding the smooth muscle cell (SMC)-specific isoform of α-actin (α-SMA), cause thoracic aortic aneurysms and dissections and occlusive vascular diseases, including early onset coronary artery disease and stroke. We have shown that occlusive arterial lesions in patients with heterozygous ACTA2 missense mutations show increased numbers of medial or neointimal SMCs. The contribution of SMC hyperplasia to these vascular diseases and the pathways responsible for linking disruption of α-SMA filaments to hyperplasia are unknown. Here, we show that the loss of Acta2 in mice recapitulates the SMC hyperplasia observed in ACTA2 mutant SMCs and determine the cellular pathways responsible for SMC hyperplasia. Acta2(-/-) mice showed increased neointimal formation following vascular injury in vivo, and SMCs explanted from these mice demonstrated increased proliferation and migration. Loss of α-SMA induced hyperplasia through focal adhesion (FA) rearrangement, FA kinase activation, re-localization of p53 from the nucleus to the cytoplasm and increased expression and ligand-independent activation of platelet-derived growth factor receptor beta (Pdgfr-β). Disruption of α-SMA in wild-type SMCs also induced similar cellular changes. Imatinib mesylate inhibited Pdgfr-β activation and Acta2(-/-) SMC proliferation in vitro and neointimal formation with vascular injury in vivo. Loss of α-SMA leads to SMC hyperplasia in vivo and in vitro through a mechanism involving FAK, p53 and Pdgfr-β, supporting the hypothesis that SMC hyperplasia contributes to occlusive lesions in patients with ACTA2 missense mutations.

  11. [The computer assisted pacemaker clinic at the regional hospital of Udine (author's transl)].

    PubMed

    Feruglio, G A; Lestuzzi, L; Carminati, D

    1978-01-01

    For a close follow-up of large groups of pacemaker patients and for evaluation of long term pacing on a reliable statistical basis, many pacemaker centers in the world are now using computer systems. A patient data system with structured display records, designed to give complete, comprehensive and surveyable information and which are immediately retrievable 24 hours a day, on display or printed sets, seems to offer an ideal solution. The pacemaker clinic at the Regional Hospital of Udine has adopted this type of system. The clinic in linked to a live, on-line patient data system (G/3, Informatica Friuli-Venezia Giulia). The input and retrieval of information are made through a conventional keyboard. The input formats have fixed headings with coded alternatives and a limited space for comments in free text. The computer edits the coded information to surveyable reviews. Searches can be made on coded information and data of interest.

  12. [Antimicrobial therapy in pregnancy (author's transl)].

    PubMed

    Reinlein, J M; Garcia, F S

    1979-12-14

    At the present time there is no medicament completely harmless to the embryo or fetus. Passage through the placenta probably occurs by simple diffusion. Substances with a molecular weight under 600, low protein binding, a low degree of ionization and good solubility in lipids cross the placenta most easily. The harmful effects of the different groups of medicaments are describedand the substances classified into those not particularly toxic, those which can only be used in certain conditions and those only to be used in exceptional cases. The treatment of the most common infections in pregnancy is dealth with in detail. Infections of the maternal urinary tract and amnionitis raise most problems. For the treatment of amnionitis, direct instillation of the medicament into the amniotic sac is recommended.

  13. Antibacterial properties of the Vietnamese cajeput oil and ocimum oil in combination with antibacterial agents.

    PubMed

    Jedlicková, Z; Mottl, O; Serý, V

    1992-01-01

    Main antibacterially active agents obtained from plants-Cajeput essential oil--1,8 cineol, linalool, alpha-terpineol and terpinen-4-ol, for example from Melalleuce leucadendron (Myrtaceae) as well as essential oil from Ocimum gratissimum (Labiatae) were combined in tests in vitro with selected antibiotics. Above mentioned plant products were found to be effective medicaments for local application in modern medical practice. Combinations with antibiotics potentiated their therapeutical action. On the basis of tests in vitro the synergistic action of these two kinds of medicaments, i.e., preparations traditionally used for a few last decades--antibiotics--might be well applied for therapeutical needs.

  14. [Reflections about the historical development of biomedical sciences in Chile and the role of Revista Médica de Chile: an homage on 130-years old].

    PubMed

    Vargas Fernández, Luis

    2002-12-01

    When Revista Médica de Chile turns to be 130 years old, the author reflects about the difficulties that scientific and technological creativity faces in Chile, considering that there was a 70 years gap between its historical origin in Chile compared to developed countries. The scientific progress erases the boundaries between Biomedicine and science and technology. This progress has resulted in an improvement in the quality of scientific publications in Revista Medica de Chile. The editorial work has also contributed to this improvement. Revista Medica de Chile has obtained international recognition and stands in a good position as a medical journal in Latin America and Chile.

  15. [Fake malaria drugs].

    PubMed

    Bygbjerg, Ib Christian

    2009-03-02

    The literature on fake medicaments is sparse, even if approximately 15% of all medicaments are fake, a figure that for antimalarials in particular reaches 50% in parts of Africa and Asia. Sub-standard and fake medicines deplete the public's confidence in health systems, health professionals and in the pharmaceutical industry - and increase the risk that resistance develops. For a traveller coming from a rich Western country, choosing to buy e.g. preventive antimalarials over the internet or in poor malaria-endemic areas, the consequences may be fatal. International trade-, control- and police-collaboration is needed to manage the problem, as is the fight against poverty and poor governance.

  16. Origin and characterization of alpha smooth muscle actin-positive cells during murine lung development.

    PubMed

    Moiseenko, Alena; Kheirollahi, Vahid; Chao, Cho-Ming; Ahmadvand, Negah; Quantius, Jennifer; Wilhelm, Jochen; Herold, Susanne; Ahlbrecht, Katrin; Morty, Rory E; Rizvanov, Albert A; Minoo, Parviz; El Agha, Elie; Bellusci, Saverio

    2017-04-03

    ACTA2 expression identifies pulmonary airway and vascular smooth muscle cells (SMCs) as well as alveolar myofibroblasts (MYF). Mesenchymal progenitors expressing fibroblast growth factor 10 (Fgf10), Wilms tumor 1 (Wt1), or glioma-associated oncogene 1 (Gli1) contribute to SMC formation from early stages of lung development. However, their respective contribution and specificity to the SMC and/or alveolar MYF lineages remain controversial. In addition, the contribution of mesenchymal cells undergoing active WNT signaling remains unknown. Using Fgf10(CreERT2) , Wt1(CreERT2) , Gli1(CreERT2) , and Axin2(CreERT2) inducible driver lines in combination with a tdTomato(flox) reporter line, the respective differentiation of each pool of labeled progenitor cells along the SMC and alveolar MYF lineages was quantified. The results revealed that while FGF10(+) and WT1(+) cells show a minor contribution to the SMC lineage, GLI1(+) and AXIN2(+) cells significantly contribute to both the SMC and alveolar MYF lineages, but with limited specificity. Lineage tracing using the Acta2-CreERT2 transgenic line showed that ACTA2(+) cells labeled at embryonic day (E)11.5 do not expand significantly to give rise to new SMCs at E18.5. However, ACTA2(+) cells labeled at E15.5 give rise to the majority (85%-97%) of the SMCs in the lung at E18.5 as well as alveolar MYF progenitors in the lung parenchyma. Fluorescence-activated cell sorting-based isolation of different subpopulations of ACTA2(+) lineage-traced cells followed by gene arrays, identified transcriptomic signatures for alveolar MYF progenitors versus airway and vascular SMCs at E18.5. Our results establish a new transcriptional landscape for further experiments addressing the function of signaling pathways in the formation of different subpopulations of ACTA2(+) cells. Stem Cells 2017.

  17. Modulating myosin restores muscle function in a mouse model of nemaline myopathy

    PubMed Central

    Lindqvist, Johan; Levy, Yotam; Pati‐Alam, Alisha; Hardeman, Edna C.; Gregorevic, Paul

    2016-01-01

    Objective Nemaline myopathy, one of the most common congenital myopathies, is associated with mutations in various genes including ACTA1. This disease is also characterized by various forms/degrees of muscle weakness, with most cases being severe and resulting in death in infancy. Recent findings have provided valuable insight into the underlying pathophysiological mechanisms. Mutations in ACTA1 directly disrupt binding interactions between actin and myosin, and consequently the intrinsic force‐generating capacity of muscle fibers. ACTA1 mutations are also associated with variations in myofiber size, the mechanisms of which have been unclear. In the present study, we sought to test the hypotheses that the compromised functional and morphological attributes of skeletal muscles bearing ACTA1 mutations (1) would be directly due to the inefficient actomyosin complex and (2) could be restored by manipulating myosin expression. Methods We used a knockin mouse model expressing the ACTA1 His40Tyr actin mutation found in human patients. We then performed in vivo intramuscular injections of recombinant adeno‐associated viral vectors harboring a myosin transgene known to facilitate muscle contraction. Results We observed that in the presence of the transgene, the intrinsic force‐generating capacity was restored and myofiber size was normal. Interpretation This demonstrates a direct link between disrupted attachment of myosin molecules to actin monomers and muscle fiber atrophy. These data also suggest that further therapeutic interventions should primarily target myosin dysfunction to alleviate the pathology of ACTA1‐related nemaline myopathy. Ann Neurol 2016;79:717–725 PMID:26891371

  18. Pseudopolymorphism in hydroxybenzophenones: the dihydrate of 2,2',4,4'-tetrahydroxybenzophenone.

    PubMed

    Landre, I M R; Martins, F T; Ellena, J A; Dos Santos, M H; Doriguetto, A C

    2012-04-01

    A dihydrate pseudopolymorph of bis(2,4-dihydroxyphenyl)methanone, C(13)H(10)O(5)·2H(2)O, (I), was obtained during polymorphism screening of hydroxybenzophenone derivatives. This structure, in which the molecule sits on a twofold axis, was compared with the known anhydrous form of (I) [Schlemper (1982). Acta Cryst. B38, 554-559]. The role of water in the crystal assembly was established on the basis of the known monohydrate pseudopolymorph of 3,4-dihydroxybenzophenone [Landre, Souza, Corrêa, Martins & Doriguetto (2010). Acta Cryst. C66, o463-o465].

  19. Multiscale Modeling and Process Optimization for Engineered Microstructural Complexity

    DTIC Science & Technology

    2007-10-26

    2005. 25. R. T. Brewer , D. A. Boyd, M. Y. El-Naggar, S. W. Boland, Y.-B. Park, S. M. Haile, D. G. Goodwin, and H. A. Atwater, Growth of biaxially...Zhang and K. Bhattacharya. A computational model of ferroelectric domains. Part II: Grain boundaries and defect pinning. Acta Materialia 53: 199...electromechanical actuation Acta Materialia, 51, 5941-5960, 2003. 37. R.T. Brewer , H.A. Atwater, J.R. Groves and P.N. Arendt Reflection high-energy electron

  20. Integration of Statistical and Physical Models of Short Fatigue Crack Growth.

    DTIC Science & Technology

    1987-02-01

    M.R. James and B.N. Cox, *Fundamental Characterization of Surface Microplasticity ," Final Report on NSF Grant No. DMR-8310652, July 1986. 23. W.L...Dec. 1985. 24. W.L. Morris, B.N. Cox and M.R. James, " Microplastic Deformation of Al 2219- T85 I," to be published in Acta Metall. 25. B.N. Cox, W.L...Morris and M.R. James, "Two-Stage Microplastic Surface Defor- mation in Al 2219-T851," to be published in Acta Metall. 26. W.L. Morris, M.R. James and

  1. A Novel Approach to Regeneration of Bone: Using Focused Ultrasound for the Spatiotemporal Patterning of Angiogenic and Osteogenic Factors

    DTIC Science & Technology

    2012-04-01

    FM, Ruíz-Hernández, E, Boré, A, Arcos , D, Vallet-Regí, M and Vilaboa, N . Acta Biomater 6:12, 4522-31 (2010) 10 APPENDICES 1.) Abstract submitted...Martín-Saavedra FM, Ruíz-Hernández E, Boré A, Arcos D, Vallet-Regí M, and Vilaboa N . Acta Biomater 6, 2010, pp.4522-31. 5. Kruse DE, Mackanos MA...unstimulated controls. Data are means + standard deviation for n = 3. We have characterized the kinetics of activation and re-inducibility of 10T1/2

  2. Temperature Regulation during Upper Body Exercise: Able Bodied and Spinal Cord Injured

    DTIC Science & Technology

    1989-04-01

    REFERENCES 1. Asmussen. E. and M . Nielsen. The regulation of the body temperature during work performed with the arms and with the legs. Acta Physiol. Scand...14:373-382. 1947. 2. Astrand. I. Aerobic work capacity in men and women. Acta Physiol. Scand. 49: (Suppl. 169)64-73, 1960. 3. Attia, M . and P. Engel...9:225-228. 1984. 10. Downey. J.A.. H.P. Chiodi and R.C. Darling. Central temperature regulation in the spinal man. J. AppI. Physiol. 22:91-94. 1967

  3. An In Vivo Selection Identifies Listeria monocytogenes Genes Required to Sense the Intracellular Environment and Activate Virulence Factor Expression

    PubMed Central

    Portnoy, Daniel A.

    2016-01-01

    Listeria monocytogenes is an environmental saprophyte and facultative intracellular bacterial pathogen with a well-defined life-cycle that involves escape from a phagosome, rapid cytosolic growth, and ActA-dependent cell-to-cell spread, all of which are dependent on the master transcriptional regulator PrfA. The environmental cues that lead to temporal and spatial control of L. monocytogenes virulence gene expression are poorly understood. In this study, we took advantage of the robust up-regulation of ActA that occurs intracellularly and expressed Cre recombinase from the actA promoter and 5’ untranslated region in a strain in which loxP sites flanked essential genes, so that activation of actA led to bacterial death. Upon screening for transposon mutants that survived intracellularly, six genes were identified as necessary for ActA expression. Strikingly, most of the genes, including gshF, spxA1, yjbH, and ohrA, are predicted to play important roles in bacterial redox regulation. The mutants identified in the genetic selection fell into three broad categories: (1) those that failed to reach the cytosolic compartment; (2) mutants that entered the cytosol, but failed to activate the master virulence regulator PrfA; and (3) mutants that entered the cytosol and activated transcription of actA, but failed to synthesize it. The identification of mutants defective in vacuolar escape suggests that up-regulation of ActA occurs in the host cytosol and not the vacuole. Moreover, these results provide evidence for two non-redundant cytosolic cues; the first results in allosteric activation of PrfA via increased glutathione levels and transcriptional activation of actA while the second results in translational activation of actA and requires yjbH. Although the precise host cues have not yet been identified, we suggest that intracellular redox stress occurs as a consequence of both host and pathogen remodeling their metabolism upon infection. PMID:27414028

  4. UF Biomotor/Biosensor Nanotechnologies

    DTIC Science & Technology

    2007-09-25

    beads by taking the product of the volume of stock beads and surface area of one bead by the volume of one bead (0.338 m2 for 50 IiL of 5.63% (v/v) stock...BSA) divided by the circumference of the Stokes radius of ActA (6.3 nm for ActA and 3.5 nm for BSA). The product of bead area and protein mass/area...data not shown). To address this issue, we first noted that DHLA QDs coated with maltose binding protein (MBP) did not aggregate in the cytoplasm of

  5. 75 FR 3523 - Additional Designation of Entities and Individuals Pursuant to Executive Order 12978

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ...); (INDIVIDUAL) . 11. LOPEZ RODRIGUEZ, Walter, c/o CARMILE INVERSIONES LOPEZ Y CIA. S.C.A., Cali, Colombia; c/o... INVERSIONES LOPEZ Y CIA. S.C.A., Cali, Colombia; c/o INVERSIONES MEDICAS Y QUIRUGICAS ESPECIALIZADAS LTDA... TERESITA S.A., Cali, Colombia; c/o BOSQUE DE SANTA TERESITA LTDA., Cali, Colombia; c/o SAAVEDRA Y CIA....

  6. A Integracao de Ensino das Ciencias da Saude (An Integrated Medical Education Program [in Brazil]).

    ERIC Educational Resources Information Center

    Pourchet-Campos, M. A.; Guimaraes Junior, Paulino

    At the Sixth Annual Reunion of the Brazilian Association of Medical Schools (VI Reuniao Anual da Associacao Brasileira de Escolas Medicas) leaders in the Brazilian medical profession proposed an integrated educational program for training students in the fields of medicine and public health. Under Brazil's present system of education, all…

  7. 76 FR 70520 - Rovac Corp., RS Group of Companies, Inc., Rymer Foods, Inc. Stratus Services Group, Inc., Sun Cal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... COMMISSION Rovac Corp., RS Group of Companies, Inc., Rymer Foods, Inc. Stratus Services Group, Inc., Sun Cal Energy, Inc., Sun Motor International, Inc., Surebet Casinos, Inc., and Swiss Medica, Inc.; Order of... Sun Cal Energy, Inc. because it has not filed any periodic reports since the period ended March...

  8. Quality of Indexing in Online Data Bases.

    ERIC Educational Resources Information Center

    White, Howard D.; Griffith, Belver C.

    1987-01-01

    Describes study that compared and judged the quality of subject indexing in online bibliographic databases. Documents from medical behavioral science literature are used with terms drawn from MEDLINE, PsychINFO, BIOSIS, and Excerpta Medica. Comparative statistics are presented on how each database links related documents and discriminates among…

  9. Cost Comparison of Abstracts and Indexes on Paper, CD-ROM, and Online.

    ERIC Educational Resources Information Center

    Cohen, Elaine; Young, Margo

    1986-01-01

    Describes a model enumerating cost factors for comparing costs for paper, online, and CD-ROM indexes and abstracts. The model is applied to start-up and annual costs, and to the cost of storing and providing access to ERIC, Applied Science and Fisheries Abstracts, and Excerpta Medica, based on anticipated academic library usage. (MBR)

  10. Combinatorial Strategies and Hypothesis-Based Drug Design in Drug Discovery Targeted to the Protease and Channel Activities of Botulinum Toxin A

    DTIC Science & Technology

    2000-02-01

    Program, Stanfi"e University Medica ! Sckhool, S ants- CA -4305 Universty, Stanford, CA 94305. We have adac!ed fluorescent in situ hybridizatio" z!S...Elche. Spain. ("Departamento de Bioquimica y Biologia Molecular. Universitat de Valencia. Burjassot. Spain. (4bDepartment of Biology. University of

  11. International Symposium on Neurotoxins in Neurobiology (4th) Held in Bath, United Kingdom on 19th-23rd September 1993. Speakers’ Abstracts 1-25

    DTIC Science & Technology

    1993-01-01

    Jorge H. Medina+ 0 *Instituto de Quimica y Fisiocoquimica Biologicas, Facultad de Farmacia y Bioquimica , Junin 956 (1113) and +Instituto de Biologia...Action", pp 6-67. Lunt. G.G. (Ed). Excerpta Medica . Elsevier, Amsterdam. 8. Jackson. H. and Usherwood. P.N.R. (1988). TINs, 11, 278-283. 0 "* 0 0 01 0

  12. Laser-assisted drug delivery in dermatology: from animal models to clinical practice.

    PubMed

    Ali, Faisal R; Al-Niaimi, Firas

    2016-02-01

    Topical medicaments are the mainstay of the dermatologists' therapeutic arsenal. Laser-assisted drug delivery enhances the ability of topically applied medicaments to penetrate the skin. We discuss the mechanisms of laser-assisted drug delivery and animal models that have informed clinical practice. We review clinical studies that have employed laser-assisted drug delivery for a range of indications to date including non-melanoma skin cancer, vitiligo, scarring, vaccination, local anaesthesia, analgesia, viral warts, infantile haemangiomas and cosmetic uses. Studies thus far suggest that laser pre-treatment improves transepidermal absorption of topical agents and allows for a much deeper penetration of drugs than is possible with topical medicaments alone. This may allow more efficacious action of current treatments, such that conventional duration of treatment can be shortened or lower concentrations of active agents be used, potentially obviating side effects of treatment. The prospect of using laser technologies to facilitate transdermal vaccination and as an adjunct for inflammatory dermatoses and cosmetic indications remains in its infancy. As larger trials are published, involving greater numbers of patients and utilising various laser and topical medicament parameters, we will enhance our understanding of this nascent modality of treatment delivery.

  13. Searching the History of Science Online.

    ERIC Educational Resources Information Center

    Skinner, Robert E.

    1983-01-01

    Surveys major databases offering access to historical and biographical information in the sciences and highlights special features of each--Histline, America: History and Life, Historical Abstracts, Agricola, Biosis Previews, CA Condensates, Compendex, Excerpta Medica, Inspec, and Medline. Two references are listed. (EJS)

  14. Bibliography on Venezuelan Equine Encephalomyelitis (VEE). Supplement 7, 1247-1300.

    DTIC Science & Technology

    1982-05-01

    1089, 1213, 1260 Reitmwn, M. 347, 350, 537 Reta Pettersson, C. A. 736, 737, 895 Revista Medica Dominicana 351 Revista Venezolana Sanidad Asistencia ... Social 352 Revo, M. V. 353 Reynolds, J. A. 1283, 1284 Reynolds, S. L. 79, 354 Rhodes, H. A. 998 Richmond, G. 252 Richter, H. 896 Riemann, H. P. 1056

  15. [Clinical use and action mechanism of propranolol].

    PubMed

    Tieri, O; Polzella, A

    1975-01-01

    Propranololum reduces the intraocular tension by inhibiting the production of aqueous humour. In about 50% of all cases the medicament, given as 1% drops, proves an effective anti-glaucomatous agent. Combined with adrenaline it is particularly effective and well tolerated.

  16. Application of Multilocus Sequence Typing To Study the Genetic Structure of Megaplasmids in Medicago-Nodulating Rhizobia

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A multilocus sequence typing (MLST) analysis was used to examine the relatedness and distribution of genotypic variants of the two large extrachromosomal replicons in Medicago-nodulating rhizobia (Sinorhizobium meliloti and S. medicae). One goal was to develop a strategy for the characterization of...

  17. [Pharmacological prophylaxis of vestibulo-autonomous syndrome (motion sickness) in model investigations].

    PubMed

    Shashkov, V S; Iasnetsov, V V; Shashkov, A V; Il'ina, S L; Galle, R R; Sabaev, V V; Potapov, M G

    2000-01-01

    The authors summarize results of multiyear investigations at the Institute of Biomedical Problems of induced motion sickness and development of prophylactic medicaments representing various classes of biologically active substances (choline blocking agents, sympathomimetics, antihistamines etc.) prescribed singularly or in an combination based on the knowledge of MS-provoking inter-receptor interactions and therapeutic effects of drugs.

  18. [Cartesianism and Henricus Regius' dentistry (1598--1679--1979) (Henricus de Roy, René Descartes].

    PubMed

    Gysel, C

    1979-01-01

    Henricues Regius (1598--1679), professor at the University of Utrecht was the first physician who accepted the physiology of the philosopher Descartes (1596--1750) that he exposed in Fundamenta physices (1646) and in Fundamenta Medicinae (1647) but in Praxis Medica (1657) his therapy of the "odontalgia" is still mediaeval according to the principles of Galen.

  19. Changes in anthocyanin production during domestication of citrus

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Mandarin (C. reticulata), citron (C. medica) and pummelo (C. maxima) are imortant fruit species of the genus Citrus and parents of the interspecific hybrids that constitute the most familiar commercial varities of citrus: sweet orange, sour orange, clementine, lemon lme and grapefruit. Citron and it...

  20. Sealing Quality of a Temporary Filling Material.

    DTIC Science & Technology

    1977-05-10

    microorganisms from gaining entrance into the root canal , thus preventing infection or re-infection; second, to prevent medicaments placed into the pulp ...integrity and stored until their use in water. Endodontic access cavity preparations were performed . The pulp chamber content was removed but no attempt

  1. Vanga Bhasma and its XRD analysis

    PubMed Central

    Hiremath, Rudramma; Jha, C.B.; Narang, K.K.

    2010-01-01

    Bhasmas are potent Ayurvedic medicaments, biologically active and powerful healing preparations in all aspects. Properly prepared Bhasmas have not reported any serious untoward effects in clinical practice. Vanga Bhasma is an effective Ayurvedic medicine among various Bhasmas which are classically explained and advised specially in genitourinary disorders. XRD peaks of Vanga Bhasma are identified to be as Tindioxide (SnO2) PMID:22557364

  2. Computerized Drug Information Services

    ERIC Educational Resources Information Center

    And Others; Smith, Daniel R.

    1972-01-01

    To compare computerized services in chemistry, pharmacology, toxicology, and clinical medicine of pharmaceutical interest, equivalent profiles were run on magnetic tape files of CA-Condensates," CBAC," Excerpta Medica," MEDLARS" and Ringdoc." The results are tabulated for overlap of services, relative speed of citing references, and unique…

  3. The Effects of Middle Ear Pressure on Hearing.

    DTIC Science & Technology

    1984-04-30

    Hultcrantz et al., 1982; Larsen et al., 1982; Prazma & Rogers , 1982); 3) direct visualization of flow in selected cochlear vessels (Perlman & Kimura, 1955...Plenum Publishers, New York. 4. DeVincetits, I., Bozzi, L. and Pizzichetta, V. 1964. Sulla terapia medica di alcuwe gravi ipoacusie. Valsalua 40:65-79

  4. Online Database Coverage of Forensic Medicine.

    ERIC Educational Resources Information Center

    Snow, Bonnie; Ifshin, Steven L.

    1984-01-01

    Online seaches of sample topics in the area of forensic medicine were conducted in the following life science databases: Biosis Previews, Excerpta Medica, Medline, Scisearch, and Chemical Abstracts Search. Search outputs analyzed according to criteria of recall, uniqueness, overlap, and utility reveal the need for a cross-database approach to…

  5. [Endodontic microbiology: antimicrobial canal medications].

    PubMed

    Seltzer, S; Farber, P A

    1989-06-01

    Medicaments used for reducing or eliminating microorganisms from infected root canals include: irrigating solutions, such as sodium hypochlorite, urea peroxide and hydrogen peroxide, chloramine, iodine-potassium-iodide solution, and chlorhexidine solution. In addition, various intracanal drugs, such as calcium hydroxide and antibiotics, are in use. The characteristics of these drugs are discussed.

  6. Identification and characterization of Citrus yellow vein clearing virus, a putative new member of the genus Mandarivirus infecting Citrus spp.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Yellow vein clearing virus, an uncharacterized filamentous virus, was first observed in Pakistan in 1988 and later in India in 1997 in Etrog citron (Citrus medica). Based on electron microscopic evidence of filamentous particles, the virus, provisionally named Citrus yellow vein clearing virus (CYVC...

  7. Quantitative and Qualitative Usage Data of an Internet-Based Asthma Monitoring Tool

    PubMed Central

    Nielsen, Lene

    2004-01-01

    Background In May 2000, AstraZeneca launched a Web service for asthma patients and health-care providers called LinkMedica, which includes an asthma diary for monitoring and self-management. In the diary, the patient enters his or her peak flow, number of doses of rescue medication, and if there have been any asthma symptoms during the previous 24 hours. The patient receives an immediate response from LinkMedica, telling him or her if the asthma is under control and what to do if not, eg, increase the dose of inhaled steroid. Health-care providers have access to the patient diary. Objectives The primary objective of the study was to describe patients' and health-care providers' use of LinkMedica. Secondary objectives were to evaluate their perception of the system and how the users' interaction with the system is influenced by their everyday lives. Methods Site statistics regarding number of registered users and diary usage were analyzed. An online survey among users (85 respondents), a mailed questionnaire to health-care providers (131 respondents; response rate 26.8%), as well as in-depth interviews with 10 patients and 5 general practitioners, elicited further quantitative and qualitative data on users' perceptions. Results In February 2003, a total of 7653 users had registered. During 2002, the growth in registered users averaged 50 per month. In the same period, the number of unique diary users per month decreased from 307 to 138. Patients usually stopped using the diary after a short time; the doctors were reluctant to introduce the diary to patients because of time constraints. Several user subtypes were identified among patients and their relatives. Conclusion The self-selected survey responses and in-depth interviews indicated that LinkMedica is generally considered a trustworthy and reliable site by both patients and doctors. However, there was a contrast between users' positive perception of LinkMedica and their unwillingness to use the site for more

  8. Improving legume nodulation and Cu rhizostabilization using a genetically modified rhizobia.

    PubMed

    Delgadillo, Julián; Lafuente, Alejandro; Doukkali, Bouchra; Redondo-Gómez, Susana; Mateos-Naranjo, Enrique; Caviedes, Miguel A; Pajuelo, Eloísa; Rodríguez-Llorente, Ignacio D

    2015-01-01

    The rhizobia-legume interaction has been proposed as an interesting and appropriate tool for rhizostabilization of soils contaminated with heavy metals. One of the main requirements to use this symbiosis is the availability of tolerant and symbiotically effective rhizobia. The aim of this work was to improve the symbiotic properties of the arsenic-resistant wild-type strain Ensifer medicae MA11 in Cu-contaminated substrates. The copAB genes from a Cu-resistant Pseudomonas fluorescens strain were expressed in E. medicae MA11 under the control of the nifH promoter. The resulting strain E. medicae MA11-copAB was able to alleviate the toxic effect of Cu in Medicago truncatula. At 300 µM Cu, root and shoot dry matter production, nitrogen content, number of nodules and photosynthetic rate were significantly reduced in plants inoculated with the wild-type strain. However, these parameters were not altered in plants inoculated with the genetically modified strain. Moreover, nodules elicited by this strain were able to accumulate twofold the Cu measured in nodules formed by the wild-type strain. In addition, the engineered E. medicae strain increased Cu accumulation in roots and decreased the content in shoots. Thus, E. medicae MA11-copAB increased the capacity of M. truncatula to rhizostabilize Cu, decreasing the translocation factor and avoiding metal entry into the food chain. The plasmid containing the nifH promoter-copAB construct could be a useful biotool for Cu rhizostabilization using legumes, since it can be transferred to different rhizobia microsymbionts of authoctonous legumes growing in Cu-contaminated soils.

  9. Influence of calcium hydroxide on the post-treatment pain in Endodontics: A systematic review

    PubMed Central

    Anjaneyulu, K.; Nivedhitha, Malli Sureshbabu

    2014-01-01

    Introduction: Pain of endodontic origin has been a major concern to the patients and the clinicians for many years. Post-operative pain is associated with inflammation in the periradicular tissues caused by irritants egressing from root canal during treatment. It has been suggested that calcium hydroxide intra-canal medicament has pain-preventive properties because of its anti-microbial or tissue altering effects. Some dispute this and reasoned that calcium hydroxide may initiate or increase pain by inducing or increasing inflammation. Objective: To evaluate the effectiveness of calcium hydroxide in reducing the post-treatment pain when used as an intra-canal medicament Materials and Methods: The following databases were searched: PubMed CENTRAL (until July 2013), MEDLINE, and Cochrane Database of Systematic Reviews. Bibliographies of clinical studies and reviews identified in the electronic search were analyzed for studies published outside the electronically searched journals. The primary outcome measure was to evaluate the post-treatment pain reduction when calcium hydroxide is used as an intra-canal medicament in patients undergoing root canal therapy. Results: The reviews found some clinical evidence that calcium hydroxide is not very effective in reducing post-treatment pain when it is used alone, but its effectiveness can be increased when used in combination with other medicaments like chlorhexidine and camphorated monochlorophenol (CMCP). Conclusion: Even though calcium hydroxide is one of the most widely used intra-canal medicament due to its anti-microbial properties, there is no clear evidence of its effect on the post-treatment pain after the chemo-mechanical root canal preparation. PMID:24944439

  10. Antibodies to Liposomal, Phosphatidylcholine and Phosphatidylsulfocholine

    DTIC Science & Technology

    1990-01-01

    Biochim. Biophys. tidylcholine have also been induced by immuniz- Acta, 689: 319-326. ing mice with bromelain -treated mouse erythrocytes (Cox BISSERET, P...with lysolecithin and sphingomyelin, thus bromelain -modified RBC are specifically inhibited by a common indicating specificity for the phosphocholine

  11. Effects of space flights on human allergic status (IgE-mediated sensitivity)

    NASA Astrophysics Data System (ADS)

    Buravkova, L. B.; Rykova, M. P.; Gertsik, Y. G.; Antropova, E. N.

    2007-02-01

    Suppression of the immune system after space flights of different duration has been reported earlier by Konstantinova [Immune system in extreme conditions, Space immunology. B. 59. M. Science 1988. 289p. (in Russian) [4]; Immunoresistance of man in space flight, Acta Astronautica 23 (1991) 123-127 [5

  12. Upper Airway Sequelae in Burn Patients Requiring Endotracheal Intubation or Tracheostomy

    DTIC Science & Technology

    1985-03-01

    airways. In adult patients, our experi - It was remarkable that autopsy findings in 12 patients ence is that as long as the nasotracheal tube is not...tracheostomy. Acta Anaesthesiol TB et al., eds. Progress in Anaesthesiology : Proceedings of the Scand 1979; 23:57-68. Fourth World Congress of

  13. Passive Dynamics in the Control of Gymnastic Maneuvers.

    DTIC Science & Technology

    1995-03-01

    that must be satis ed for the moon to exhibit stable librational motion. In 1885, Henri Poincar e [ Poincare ] realized that a linearized analysis could... Poincare ] Poincar e, H. 1885. Sur l’equilibre d’une mass uide. Acta math. VIII, 293-299. [Nigg 74] Nigg, B.M., 1974. Analysis of Twisting and Turning

  14. Prepared in Mind and Resources? A Report on Public Higher Education in South Carolina

    ERIC Educational Resources Information Center

    Alacbay, Armand; Poliakoff, Michael

    2011-01-01

    In 2011, South Carolina Governor Nikki Haley signed into law the South Carolina Higher Education Efficiency and Administrative Policies Act, maintaining the transparency and accountability that lead to increased academic quality and affordability at colleges and universities. It is in this context that ACTA (American Council of Trustees and…

  15. How technology is reshaping the practice of nongynecologic cytology: frontiers of cytology symposium.

    PubMed

    Bibbo, Marluce

    2007-01-01

    To pay tribute to the Founders of Acta Cytologica, this Golden Anniversary symposium on nongynecologic cytology revives the written symposium style of the 1950s. Participants from countries throughout the world were asked how new technologies are currently applied in their laboratories and whether future advances and challenges can be predicted. The specific questions and the participants' answers follow.

  16. 77 FR 63203 - 50th Anniversary of the Office of the United States Trade Representative

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ... Trade Representative By the President of the United States of America A Proclamation On October 11, 1962, President John F. Kennedy signed the Trade Expansion Act--a landmark piece of legislation that established a..., and build a business. NOW, THEREFORE, I, BARACK OBAMA, President of the United States of America,...

  17. A New NDE Capability for Thin-Shelled Structures

    DTIC Science & Technology

    1989-02-03

    package was enclosed with a radiation-shielded sheet-metal housing. This protected the package from ambient light, X-rays, and electro-magnetic...6] Edholm, P.R., Quiding, L., "Elimination of Blur in Linear Tomography," Acta Radiologica , Vol. 10, pp. 441-447, 1970. [71 Strohbehn, J.W., Yates

  18. Follow-Up Care for Older Women With Breast Cancer

    DTIC Science & Technology

    1999-08-01

    Resources, national Research Council (NIH Publication No. 86-23, Revised 1985). •ZFor the protection of human subjects, the investigator(s) adhered to...Cancer: Complications of Axillary Management. Acta Radiologica Oncology. 1986; 25:105-108. 16. Christenson SB and Lundgren E. Sequelae of Axillary

  19. Microstructurally Based Cross-slip Mechanisms and Their Effects on Dislocation Microstructure Evolution in fcc Crystals

    DTIC Science & Technology

    2015-01-01

    nickel microcrystals, Acta Mater. 56 (13) (2008) 2008. [58] G Makov P Landau , R Z Shneck, A. Venkert, Evolution of dislocation patterns in fcc metals, IOP...orientation: I. disloca- tion arrangement and cell structure of crystals deformed in tension, Philos. Mag. 28 (1973) 1057–1976. [61] P. Landau , R.Z. Shneck

  20. Archeological Investigations in the Truscott Reservoir Area. King and Knox Counties, Texas,

    DTIC Science & Technology

    1978-06-01

    Aspectos de Arqueologia e Historic del Noreste, Monterrey, Mexico, April 23-26, 1975. 1976 The Panhandle Archaic. In The Texas Archaic: A Symposium...Texas Panhandle. Actas del 41 Congreso Inter- nacional de Americanistas, Vol. 1, pp. 270-278. Institute Nacional de Antropologia e Historia

  1. On Dynamic Loads in Parallel Shaft Transmissions. 1. Modelling and Analysis.

    DTIC Science & Technology

    1987-08-01

    NASA CR-179473, 1986. 16. Lundberg, G.; and Palmgren , A.: Dynamic Capacity of Rolling Bearings . Acta Polytech. Mech. Eng. Sci., vol. 1, no. 3, 1947...founda- tion (ref. 15). Let qcj be the contribution to q" from the local compliance due to contact stresses. With the procedures o Lundberg and Palmgren

  2. 77 FR 72909 - International Day of Persons With Disabilities, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-06

    ... persons with disabilities through the Americans with Disabilities Act--a sweeping civil rights bill that... the rights of every person does not end at our borders, but extends to every country and every community. It continues for the woman who is at greater risk of abuse because of a disability and for...

  3. Earlier Debridement and Antibiotic Administration Decrease Infection

    DTIC Science & Technology

    2010-01-01

    closure (No Antibiotics) or treatment with tobramycin or vancomycin-impregnated polymethylmethacrylate (PMMA) beads (Antibiotics) and closed. Each time... polymethylmethacrylate beads and hip spacers in vivo. Acta Orthop. 80(2):193– 197, 2009. 10. Gustilo, R. B., Anderson, J. T. Prevention of infection

  4. An Analysis of the Microstructure and Reinforcement Distribution of an Extruded Particle-Reinforced AL 6061-10 Volume Percent Al2O3 Metal Matrix Composite

    DTIC Science & Technology

    1993-09-01

    grain diameter. An upper limit for the grain size, if boundary migration were limited by Zener drag , would obey: D= (34d) / (2 Fv) (S) with variables...Properties, Roskilde, Denmark, 2-6 September 1991. 12. Nes, E., Ryum, N., and Hunderi, 0., "On the Zener Drag ", Acta Metallurgica, Vol. 33, No. 1, p. 22

  5. Synthesis and Structural Characterization of New High-Valent Inorganic Fluorine Compounds and their Oxidizing Properties. Volume 1

    DTIC Science & Technology

    1992-02-01

    G.J. Schrobilgen, unpublished work. 48. A. Zalkin, D.L. Ward, R.N. Biagioni and D.H. Templeton, Inorg. Chem., 1978, 17, 1318. 49. N. Bartlett, B.G...Spcctrochiin. Acta 1960, 10, 505. 25. This work. 26. Zalkin. A., Ward. D.L.; Biagioni , R.N.; Templetoi, DIH.; Bartlett, N. Inorg. Chem. 1978, 17, 1318. 2.7

  6. Dielectric Analysis of Thermoset Cure.

    DTIC Science & Technology

    1985-10-07

    the polymerization of thermosetting polymers, 3. Polyst . Sci., 31, 30S (1959) 58. Warfield, R. V. * Petro*, M. C.: A study of the polymerization of...cure: isothemal curs kinetics, Ihermochimica Acta, 14. 41 (1976) 64. ludd. N. C. W.: Investigation of the polymerization of an unsaturated polyester

  7. Center for Advanced Propulsion Systems

    DTIC Science & Technology

    1993-02-01

    engine also has a Bowditch -type see-through piston. The instrumentation port was used to measure surface temperature from which the instantaneous heat...Analytical Correction for Small Viscous Heating Errors. Rheological Acta. November/December, 28,464-472. Lodge, A., Pritchard, W., and Scott , L. (1991

  8. Emergency Physician Estimation of Blood Loss

    DTIC Science & Technology

    2011-01-01

    between laboratory determination and visual estimation of blood loss during normal delivery. Eur J Obstet Gynecol Reprod Biol. 1991;38:119–124. 3...exaggeration. Acta Obstet Gynecol Scand. 2006;85:1448–1452. 4. Meiser A, Casagranda O, Skipka G, et al. Quantification of blood loss. How precise is visual

  9. Critical Percolation Stresses of Random Frank-Read Sources in Micron-Sized Crystals of Superalloys (Preprint)

    DTIC Science & Technology

    2011-11-01

    tendency for a saturation stress value, most likely because the experimental size-effect data does not include small enough sizes of micron-sized crystals...D, Gumbsch P, Kraft O, Scripta Mater 2008; 58:587. 7) Tang H, Schwarz KW, Espinosa HD, Acta Mater 2007; 55:1607. 8) Zhou C, Biner S, Lesar R

  10. Critical Percolation Stresses of Random Frank-Read Sources in Micrometer-Sized Crystals of Superalloys (Postprint)

    DTIC Science & Technology

    2012-07-09

    controls the yield stress [20]. However, the experimental data [4] do not show any such tendency for a saturation stress value, most likely because the...D M, Parthasarathy T A, Uchic M D, Tang M and Woodward C 2008 Acta Mater. 56 3245 [6] Senger J, Weygand D, Gumbsch P and Kraft O 2008 Scr. Mater. 58

  11. Organization of the Optical Society of America Photonic Science Topical Meeting Series. Volume 3. The Microphysics of Surfaces: Beam-Induced Processes Held in Santa Fe, New Mexico on 11-13 February 1991

    DTIC Science & Technology

    1992-05-22

    as semiconductor material. Impor- tant applications are thin film solar cells, thin film transistors for liquid crystal displays, photoreceptors for...171, 1989. 307-311 3 T.MINAMI, H.NANTO and S.TAKATA, Thin Solid Films, Vol.124, 1985. 43-47 4 D.Z.DA, F.R.ZHU and H.S.TANG, Acta Energiae Solaris

  12. Surface-Bound Biomembranes Incorporating Receptors: Electrochemical and Structural Characterization.

    DTIC Science & Technology

    1991-06-06

    receptnr; (Darszon, 1983; Levitzki , 1985). Here it is used to form planar structures that are potentially more stable and reproducible than the...4, 90-96. Levitzki , A.(1985). Reconstitution of membrane receptor systems. Biochim. Biophys. Acta, 822, 127-153. 16 Heuser, J.E. & Salpeter, S.R

  13. Shallow Water Reverberation and Low Frequency Seabed Scattering

    DTIC Science & Technology

    2012-09-30

    Analytical method of angular power spectrum, range and depth structure of the echo-to-reverberation ratio in shallow water Sound Field,” (Chinese) ACTA ... ACUSTICA , 5 (2), 86-99 (1980). 2. D.R. Jackson and M.D. Richardson, <High-frequency Seafloor Acoustics>, 616 pages, Springer, 2007. 3. J.X. Zhou, X.Z

  14. The Impact of Hearing Protection on Sound Localization and Orienting Behavior

    DTIC Science & Technology

    2005-06-01

    practical implications of the effects of hearing protection devices on ceedings of the Human Factors and Ergonom- localization ability. Acta ...exposure in selection of personal hearing Acustica , 22, 205-213. protection equipment for Chinook aircrews. Aviation, Space, Bolia, R. S., D’Angelo, W

  15. Hazard from an Intense Midrange Impulse

    DTIC Science & Technology

    1989-12-01

    cobaye," Acustica 59, 21-29. 1986), even up to very high sound levels, e.g., the French Hamernik, R. P.. Patterson, J. H., and Salvi. R. J. (1987...Noise on the Cat," Acta -Otolaryngol. Suppl 176, 91 pp. an energy measure at high levels. It is recognized that results MIL-STD 1474(B) (1979). "Noise

  16. Objective Measurement of the Speech Transmission Quality of Vocoders by Means of the Speech Transmission Index

    DTIC Science & Technology

    2005-04-01

    Elberling, C., Keidser, G. and Poulsen, T. (1990). Prediction of intelligibility of non- linearly processed speech. Acta Otolaryngol Suppl., 469, 190-5... Acustica 46, 59-72. [6] Steeneken, H.J.M. (1992) On measuring and predicting speech intelligibility. Soesterberg: TNO Institute for Perception

  17. The U.S. Army Research Laboratory’s Auditory Research for the Dismounted Soldier: Present (2009-2011) and Future

    DTIC Science & Technology

    2012-03-01

    S.; Bronkhorst, A. Auditory Distance Perception in Humans: A Summary of Past and Present Research. Acta Acustica 2005, 91, 409–420. 19...Laboratory. Pollard, K.A., Blumstein, D.T., & Griffin , S.C. (2010). Pre-screening acoustic and other natural signatures for use in noninvasive

  18. AFOSR(Air Force Office of Scientific Research) Chemical and Atmospheric Sciences Program Review (33rd) FY88

    DTIC Science & Technology

    1990-07-01

    and Dimethylnitrosamine", Donald F. McMillen, S. Esther Nigenda, Alicia C. Gonzales, and David M. Golden, Spectrochimica Acta Parta A, Molecular...Computer, and Systems Engineering Boston University Boston, MA 02215 Investigations of the Dynamics and Gonzalo Hernandez Thermodvnamics of the...Polar Regions. PRINCIPAL INVESTIGATOR: Gonzalo Hernandez Research Scientist Space Physics Research Laboratory University of Michigan 2455 Hayward Ann

  19. Analysis of Breast Cell-Lineage Response Differences to Taxol Using a Novel Co-Culture System

    DTIC Science & Technology

    2005-06-01

    oxide ions. These intracellular oxygen-derived free radicals, also called reactive-oxygen intermediates (ROI) accumulate intracellularly, nicking the DNA...immortalization. [Review]. Biochimica et Biophysica Acta, 1991. 1072(1): p. 1-7. 166. Harley , C.B., Telomere loss: mitotic clock or genetic time bomb

  20. Distribution and Characterization of Antigens Found in Subcellular Fractions of African Trypanosomes.

    DTIC Science & Technology

    1979-08-01

    and T. brucei Voorhies et al 1979), with the possible exception of Acanthamoeba custellani (Schultz and Thompson 1969), all demonstrate low...in membrane fragments isolated from Acanthamoeba sp. Biochem. Biophys. Acta 193 203-211. Voorheis, H.P. Gale, J.S., Owen, M.J. and Edwards W. (1979

  1. S&T Efforts for Navy Corrosion Control

    DTIC Science & Technology

    2010-11-01

    compressive surface stress Interstitially carburized layer is referred to as “S-phase” 309SS mag. 100x XRD on 316SS Ref: G. M. Michal, et al., Acta...temperature Inhibits carburization Activation via HCl thins oxide layer and allows carbon diffusion to substrate Corrosion Resistant Surface Treatment

  2. Oral Glycerol Solutions as a Deterrent to Dehydration during Heat Exposure.

    DTIC Science & Technology

    1982-01-01

    Glycerol oxidation in the animal organism Acta Physiol. Scand. 7:69-79. Larsen , Jens Anker . 1963. Elimination of glycerol as a measure of the...Following a single pharmacological oral dose the glycerol is distributed throughout 56 to 85% of the body mass (Shafrir and Gorin 1963, Larsen 1963, Holst

  3. Investigating Multitasking in High-Functioning Adolescents with Autism Spectrum Disorders Using the Virtual Errands Task

    ERIC Educational Resources Information Center

    Rajendran, Gnanathusharan; Law, Anna S.; Logie, Robert H.; van der Meulen, Marian; Fraser, Diane; Corley, Martin

    2011-01-01

    Using a modified version of the Virtual Errands Task (VET; McGeorge et al. in "Presence-Teleop Virtual Environ" 10(4):375-383, 2001), we investigated the executive ability of multitasking in 18 high-functioning adolescents with ASD and 18 typically developing adolescents. The VET requires multitasking (Law et al. in "Acta Psychol" 122(1):27-44,…

  4. Regulatory mimicry in Listeria monocytogenes actin-based motility

    PubMed Central

    Chong, Ryan; Swiss, Rachel; Briones, Gabriel; Stone, Kathryn L.; Gulcicek, Erol E.; Agaisse, Hervé

    2009-01-01

    Summary The actin-based motility of the intracellular pathogen Listeria monocytogenes relies on ActA, a bacterial factor mimicking the activity of host cell nucleation-promoting factors of the WASP/WAVE family. The activity of WASP and WAVE is tightly regulated in cells. However, it is not known whether the activity of ActA is regulated upon L. monocytogenes infection. Here, we used an RNAi-based genetic approach in combination with computer-assisted image analysis to investigate the role of host factors in L. monocytogenes spread from cell to cell. We showed that the host cell serine/threonine kinase CK2 is required for efficient actin tail formation. We demonstrated that, similar to WASP and WAVE, the affinity of ActA for the ARP2/3 complex is regulated by CK2-mediated phosphorylation. We also demonstrated the importance of this regulatory mechanism in a mouse model of infection. Our work suggests that ActA is a bacterial virulence factor that not only displays a structural mimic of the VCA domain of WASP/WAVE family members, but also co-opted CK2 as the host cell factor regulating its activity, a form of mimicry that we refer to as regulatory mimicry. We present comparative evidence supporting the notion that unrelated pathogens displaying actin-based motility may have evolved a similar strategy. PMID:19748468

  5. Stability of Dilute Tabun (GA) Solutions in Various Vehicles

    DTIC Science & Technology

    2007-11-01

    Board for Disarmament, Helsinki, 1977. 2. Larson L. The hydrolysis of dimethylamido-ethoxy-phosphoryl cyanide (Tabun), Acta Chim.Scand. 1953; 7: 306... intoxicated guinea pigs. Epilepsy Research 2000; 38: 1-14. 7. McDonough JH, McMonagle J, Copeland T, Zoeffel D, Shih T-M. A comparative evaluation of

  6. Evaluation of Composting Implementation: A Literature Review

    DTIC Science & Technology

    1990-07-13

    Yang. 1987. Properties of TNT- Degrading Enzymes in Intact Cells of Citrobacter -Freundii. Inst. Microbiol., Acad. Sinica, Beijing. Acta Microbiol Sin...27(3): 257-263. 7. Li, W., Y. Yang, and H. Yang. 1989. TNT-Degrading Enzyme of Citrobacter -Freundii and its Regulation by Carbon and Nitrogen Source

  7. Mechanisms of Retinal Damage from Chronic Laser Radiation.

    DTIC Science & Technology

    1981-07-01

    stopped at the corneal epithelium and at high intensity can cause damage there. The arc welders’ superficial keratitis and the "eyes open sun lamp...John Wiley & Sons Inc., New York, p. 218. 1967. 31. Osterberg, G.: Topography of the layer of rods and cones in the human retina. Acta

  8. Education or Reputation? A Look at America's Top-Ranked Liberal Arts Colleges

    ERIC Educational Resources Information Center

    Poliakoff, Michael; Alacbay, Armand

    2014-01-01

    ACTA [American Council of Trustees and Alumni] today released a report that examines the country's most prestigious liberal arts colleges. Despite endowments soaring as high as $1.8 billion, nearly all institutions increased tuition during the Great Recession to finance bloated administrative spending, with many college presidents enjoying…

  9. SETI-3: the Search for ExtraTerrestrial Intelligence. A selection of papers from 1987-1990 Symposia of the International Academy of Astronautics held during the 38th-41st Congress (Brighton, Bangalore, Malaga, Dresden) of the International Astronautical Federation.

    PubMed

    1992-01-01

    This special issue of Acta Astronautica is a compilation of selected papers presented at Review Meetings on SETI at the 1987-1990 International Academy of Astronautics Congresses. Papers are drawn from seven areas: bioastronomical context, SETI technology, SETI searches, radio frequency interferences, possibilities for newer instrumentation, interdisciplinary connections, and public relations. Two papers presented at the Pesek Lecture are included.

  10. Evaluation of Fuzzy Fiber Sensors for Structural Health Monitoring

    DTIC Science & Technology

    2010-11-01

    as Electrodes”, J. Ceram. Soc. Japan, 102(12); pp. 745-51 (1994). 10. M. Pumera , S. Sanchez, I. Ichinose, and J. Tang, “Electrochemical...Pingarron, Anal. Chim. Acta 622, p. 11, (2008). 16. M. Pumera , S. Sanchez, I. Ichinose, and J. Tang, Sens. Actuators B 123, p. 1195 (2007). 17. K

  11. Amnesia Production by Visual Stimulation.

    DTIC Science & Technology

    1982-12-01

    electroconvulsive shock-produced retro- grade amnesia in the rat. J Comp Physiol Psychol 88:373-377 (1975). 5. Cronholm, B., and L. Molander. Memory...disturbances after electrocon- vulsive therapy : 5. Conditions one month after a series of treat- ments. Acta Psychiatr Scand 40:211-216 (1964). 6. Dinc, H. I

  12. Increased expression of a plant actin gene during a biotrophic interaction between round-leaved mallow, Malva pusilla, and Colletotrichum gloeosporioides f. sp. malvae.

    PubMed

    Jin, S; Xu, R; Wei, Y; Goodwin, P H

    1999-10-01

    Two actin genes, actA from the hemibiotrophic anthracnose fungus, Colletotrichum gloeosporioides (Penz.) Penz. & Sacc. f. sp. malvae, and act1 from its host, Malva pusilla (Sm.) were cloned from a cDNA library developed from infected host tissue. The actin gene, actA, of C. gloeosporioides f. sp. malvae, which is similar to that of other euascomycetes, appears to be expressed constitutively. The actin gene of M. pusilla is most similar to one of the actin genes of Arabidopsis thaliana that is unique in being responsive to environmental stimuli such as wounding. Expression of actA was used to follow the growth of the fungus in the plant tissue. Low actA expression occurred until 72-96 h after inoculation and then increased rapidly, corresponding with the timing of the shift from slower biotrophic fungal growth to much more rapid necrotrophic growth. In contrast, expression of act1 approximately doubled during the biotrophic phase and then rapidly declined during the necrotrophic phase. Increased host actin expression could be due to host cytoskeleton rearrangement in response to biotrophic infection, and the subsequent decrease in host actin expression could be due to host cell disruption resulting from tissue maceration during necrosis. This is the first report of a host actin gene that can increase in expression during a compatible plant-pathogen interaction.

  13. The Cost of Chaos in the Curriculum. Perspectives on Higher Education

    ERIC Educational Resources Information Center

    Capaldi Phillips, Elizabeth D.; Poliakoff, Michael B.

    2015-01-01

    ACTA's report "The Cost of Chaos in the Curriculum" reveals that the vast array of course choices given to college students is a cause of exploding costs and poor academic outcomes. And a bloated undergraduate curriculum is particularly detrimental to the success of students from lower socioeconomic backgrounds. The report documents how…

  14. AFRRI (Armed Forces Radiobiology Research Institute) Reports, October, November, December 1986

    DTIC Science & Technology

    1986-12-01

    55,492 Beer, M., Stern, S., Carmalt, D. & Mohlhenrich, K. H. (1966) Biochemistry 5, 2283-2288 Behrend, R. & Roosen, O. (1889) Justus Liebigs Ann. Chem...227, 375-381 Chang, C. H., Ford, H. & Behrman, E. J. (1981) Inorg. Chim. Acta 55, 77-80 Criegee, R. (1936) Justus Liebigs Ann. Chem. 522, 75-93

  15. Final Sequestration Report for Fiscal Year 2013

    DTIC Science & Technology

    2013-03-01

    program integrity initiatives. In addition, on August 20, 2012, OMB released its estimate of the maxi - mum extent to which the caps for 2013 can be...With those reductions, the overall limit on discretionary 2014 2015 2016 2017 2018 2019 2020 2021 Caps Set in the Deficit Control Acta Defense

  16. Bold Leadership Real Reform [Annual Report, 2014

    ERIC Educational Resources Information Center

    American Council of Trustees and Alumni, 2015

    2015-01-01

    Higher education has never been more "front and center"--almost daily we hear about spiraling costs, the lack of academic rigor, and the stifling political correctness on our college campuses. Long before such issues were hot, ACTA [American Council of Trustees and Alumni] was already pointing out these worrisome trends and calling on…

  17. Genetics Home Reference: cap myopathy

    MedlinePlus

    ... fibers and are important for muscle contraction. Attachment (binding) and release of the overlapping thick and thin filaments allows them to move relative to each other so that the muscles can contract. The mutation in the ACTA1 gene that causes ...

  18. Genetics Home Reference: intranuclear rod myopathy

    MedlinePlus

    ... fibers and are important for muscle contraction. Attachment (binding) and release of the overlapping thick and thin filaments allows them to move relative to each other so that the muscles can contract. ACTA1 gene mutations that cause intranuclear rod myopathy ...

  19. Genetics Home Reference: actin-accumulation myopathy

    MedlinePlus

    ... fibers and are important for muscle contraction. Attachment (binding) and release of the overlapping thick and thin filaments allows them to move relative to each other so that the muscles can contract. ACTA1 gene mutations that cause actin-accumulation myopathy ...

  20. Ruthenium Oxide-Based Microelectrochemical Devices: Electrochemical Behavior of the Oxide Formed by Reduction of RuO4(2-)

    DTIC Science & Technology

    1988-08-15

    Pizzini, S.; Buzzana , G.; Marl, C.; Rossi, K.; Torcho, S. Mat. Res. Bull., 1972, 7, 449. * 10. Sze, S. M. Physics of Semiconductor Devices, 2nd Edition...Kim, K.S.; Winograd, N. J. Catal., 1974, 35, 66; (b) Folkesson, B. Acta Chem. Scand. 1973, 27, 287. 13. (a) Trassati, S.; Buzzana , G. J. Electroanal