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Sample records for acta zoologica sinica

  1. Acta Genetica Sinica (Selected Articles),

    DTIC Science & Technology

    1986-04-04

    0879-8SF/ /3 N IT 0󈧬 112. MIRCK L~~Nj~ %. *- - - - - - - - -I.. * .. - II , I FTD-ID(RS)T-0879-85 oM FOREIGN TECHNOLOGY DIVISION ACTA GENETICA SINICA...34 ’ ° ° ° !4 :A.. it.i FTD- ID(RS)T-0879-85 HUMAN TRANSLATION FTD-ID(RS)T-0879-85 4 April 1986 MICROFICHE NR: FTD-86-C-001691 ACTA GENETICA SINICA...merged into this translation were extracted from the best quality copy available. •i 12 (2): 93-101, 1985 Yichuan Xuebao (Acta Genetica Sinica) Genetic

  2. [The thirty years of Acta Genetica Sinica].

    PubMed

    Li, Shao-Wu; Zhou, Su; Xue, Yong-Biao; Zhu, Li-Huang

    2003-04-01

    Acta Genetica Sinica (AGS) is sponsored by the Genetics Society of China and the Institute of Genetics and Developmental Biology of Chinese Academy of Sciences, and is published by Science Press. The journal is a leading national academic periodical and one of the Chinese key periodicals of natural sciences. Currently, AGS is being indexed by several well-known domestic and international indexing systems, such as the American Chemical Digest (CA), BIOSIS database, Biological Digest (BA), Medical Index and Russian Digest (P [symbol: see text]). Papers in the areas of genetics, developmental biology, cell molecular biology and evolution are regularly published by AGS.

  3. Acta Aerodynamica Sinica,

    DTIC Science & Technology

    1986-11-03

    r &t ar + rx Re -1 ar r ((vur) + 3t) O a~ p ~~ (u 4) r aX 2 -T...radius of curvature of the surface and R is the gas constant. For the dust (a,u , r ) +t--(,ur. (a,u,/h) ’) P + V , , + a uv, F,±L - &I +a"v - ’ R "h - IC...h,~h Here, r is the dust particle concentration. The mutual interaction force is F..Ua_____ T, Tm where Tm=4d2 p Re , Re=av(Up-U)2+(Vp-v)2 d P P

  4. Acta Mechanica Sinica (Selected Articles).

    DTIC Science & Technology

    1981-09-15

    Hodgkings have all tried to calculate equation (7.1) with non-steady state method. For reference, see [1, 17, 18]. They call this the dynamic...Pe,,.yu (9*16). Sci,’ua Sinea (1977), 287- 304 .- 19 J ,a.-,eieKKa*. 0. A.. MaTOMaTI4e.K11e u(ipocu ,tIHa,,K)I a3KO Nt aeiolk Nw.KrA.ocT.. l:i0IAr

  5. Acta Aeronautica et Astronautica Sinica,

    DTIC Science & Technology

    1983-07-28

    displacement of the origin in1] the various directions, and da.. = cdP . Figure l(c) shows13 Jj* the model [7) obtained by modifying the moving hardening...1 -. 𔃼 1sinl[ QQ(, - ,) + ,¢+2i.,.. - -) Q ( ) + 4,++ 24.)J The constant vector v can be determined from x (tf ) = 0. Sx ,+x 2 ,-1 o )+ F(-(X39-)e

  6. Acta Aeronautica et Astronautica Sinica,

    DTIC Science & Technology

    1982-10-14

    3 400 Fig.2 Gand specimas - 1--plate; 2--washer; 3--screw head; 4-- crack warning transducer The Ko,* at stress concentration point in the structure...628 office 1975 [4] R. E. Peterson, Design Stress Concentrating Coefficient, China Industrial Publication Co. 1965. 66 I- THE CRACK -FREE LIFE...this large scale structural component was carried out using these two spectra. The stress spectrum was obtained by directly measuring at the cracked f

  7. Acta Aeronautica et Astronautica Sinica.

    DTIC Science & Technology

    1981-12-29

    SPECIMENS 68 WITH SINGLE EDGE NOTCH Liu Ligeng, Chen Xianxi and Cai Qigong (Central Iron and Steel Research Institute) ON THE DESIGN OF TRANSONIC TURBINE...et al, Mechanism of Overload Effect on Fatigue Crack Propagation in Aluminum Alloy. Eng. Fract. Mech. 1978 No. 2. (13) Chen Hu, Cai Qigong et al...this paper. 67b J-INTEGRAL EXPERIMENTAL CALIBRATION OF SHEET SPECIMENS WITH SINGLE EDGE NOTCH Lui Ligeng, Chen Xianxi and Cai Qigong (Central Iron and

  8. Acta Aeronautica et Astronautica Sinica.

    DTIC Science & Technology

    1987-04-07

    technology. Recently the design of aircraft structure has already been developed into the stages of safety lifetime and damage tolerance. It is required to...but also influenced by the interior structures and the fatigue damages produced in manufacture and application. Iri i Ino’., although some models...downward wing. Special attention should be paid to the joint design of ,)f nomposite materials. An inadequate joint design will lead to early joint damage

  9. Acta Aeronautica et Astronautica Sinica,

    DTIC Science & Technology

    1983-03-04

    numerical subsonic solution (Sells, 1968). Example 2 was an experimental wing NACA R14 A51G31 having airfoil NACA 64A010 which is perpendicular to...perpendicular to the 1/4 chord line is NACA 64A010 . X1/4= 45 , =3, n=2 . Choose a mesh of 31xl3xl9. There are 15 sections along the half wing span. Each section...small perturbation velocity potential equation and I--±0.2 were used at the blunt leading-edge. Table 1. Computed cases of NACA RM A51G31 Wing. M. a

  10. Acta Optica Sinica (Selected Articles),

    DTIC Science & Technology

    1986-04-04

    Selected Articles) C= Approved for public release; LL 4..::.: .... y ,, .,, FTD- ID(RS)T- 1089 -85 O"V%r. - HUMAN TRANSLATION FTD-ID(RS)T- 1089 -85 4 April...OPINION OF THE FOREIGN TECHNOLOGY DIVISION WPAFB. OHIO FTo- ID(RS)T- 1089 -85 Date 4 April 19 86 GRAPHICS DISCLAIMER All figures, graphics, tables

  11. Acta Aeronautica et Astronautica Sinica (Selected Articles),

    DTIC Science & Technology

    1986-05-29

    method was developed in our country using the technique with generating lines and center lines and has been applied in various aricraft design. However...public release; Distribution unlimited. - , . 16 06 *11 Zo ! 4F , FTD- ID(RS)T-1265-85 HUMAN TRANSLATION FTD-ID(RS)T-1265-85 29 May 1986 MICROFICHE...4 4 . ,, .ii Development in Vortex Motion Research /1 Liu Mouji and Su Wenhan (Beijing Institute of Aeronautics and Astronautics) Abstract This paper

  12. Acta Aeronautica et Astronautica Sinica (Selected Articles),

    DTIC Science & Technology

    1986-05-09

    N.oreover, according to K.C. Wang’s analogue senaration criter- ion , under certain conditions, the two-dimensional unsteady flow can -- 5-I be...that the seoaration line is a convergent asymp- tote of the limiting streamlines in the vicinity of the separation line. In this sen:se, therefore

  13. Acta Aeronautica et Astronautica Sinica (Selected Articles),

    DTIC Science & Technology

    1984-11-27

    Coefficients-of the Stability Augmentation System in Order to Improve Riding Qualities, by Gao Han 13 The Compilation and Application of a State-Time...34~%*** ... . Selection of the Longitudinal Feedback Coefficients /18 of the Stability Augmentation System in Order to Improve Riding Qualities...Northwestern Polytechnical University Gao Hao ABSTRACT The longitudinal feedback coefficients of a stability augmentation system (SAS) for a sample

  14. Acta Aeronautica et Astronautica Sinica (Selected Articles),

    DTIC Science & Technology

    2014-09-26

    located at the wing tip and under the wing using flexible hangers. Different span and chord positions as well as hanger pitches , yawing and sway flexibility...causing the bending of the wing surface and pitching of the external store, and (3) flutter causing the swaying of the external store and yawing. 27...almost bent by the pitch frequency of the external store *when the pitch rigidity of the external store is low. In this * case, wing bending and twisting

  15. Acta Aeronautica et Astronautica Sinica (Selected Articles)

    DTIC Science & Technology

    1988-02-18

    tables, equations, etc. merged into this tra!,slation were extracted from the best quality copy available. I I iii ti New Content of Tactical-Technical...and Astronautics SubnmitteJ December 16, 1986 Abstrac t "This paper demionstrates the importance of stealth pane- tration ability for future military...niques, etc. The emphasis of this paper is placed on the anal- ysis of the new content of tactical-technical requirements for military aircrafts in

  16. Acta Aeronautica et Astronautica Sinica (Selected Articles),

    DTIC Science & Technology

    2014-09-26

    enthalpy drops can be increased in a single-stage type turbine by con- trolling vortices at the exhaust of the gas turbine . The number or stages is...are used in experiments and their configurations are relatively simple . Based on the existing data. the general rules of wing-tip mounted winglet...in a NH-2 low-speed wind tunnel at Nanjing Institute of Aeronautics and Astronautics. The wind speed of experiments was 40 m/s. The main wing model

  17. Antioxidative oligostilbenes from Caragana sinica.

    PubMed

    Jin, Qinghao; Han, Xiang Hua; Hong, Seong Su; Lee, Chul; Choe, Sanggil; Lee, Dongho; Kim, Youngsoo; Hong, Jin Tae; Lee, Mi Kyeong; Hwang, Bang Yeon

    2012-01-15

    Two new oligostilbenes, caragasinins A (5) and B (10), and eight known compounds, kobophenol A (1), (+)-α-viniferin (2), (+)-ampelopsin F (3), pallidol (4), (+)-isoampelopsin F (6), miyabenol C (7), carasinaurone (8) and caraphenol B (9) were isolated from the ethylacetate-soluble extract of the roots of Caragana sinica. The structures of the isolates were determined on the basis of extensive spectroscopic analysis including 1D, 2D NMR and HRESI-MS. These compounds were assessed for antioxidant activities. Caragasinin A (5), caraphenol B (9), and caragasinin B (10) showed moderate DPPH scavenging activity and lipid peroxidation inhibitory activities with IC(50) values ranging from 34.7±1.0 to 89.1±2.3μM.

  18. Two new oligostilbenes from Caragana sinica.

    PubMed

    Wang, Shu-Guang; Ma, Da-You; Hu, Chang-Qi

    2004-12-01

    A new resveratrol dimer, carasiphenol A (1), and a new resveratrol trimer, carasiphenol B (2), have been isolated from the aerial parts of Caragana sinica. Their structures have been elucidated from spectroscopic evidence, especially HMBC and NOE experiments. The relative configuration of the known dimer pallidol (6) was confirmed by X-ray diffraction.

  19. Nobel laureates at the Stazione Zoologica Anton Dohrn: phenomenology and paths to discovery in neuroscience.

    PubMed

    Groeben, Christiane; de Sio, Fabio

    2006-12-01

    The practice of science usually involves more than a solitary genius in a solitary room, coping with the problem of her/his life. From the second half of the 19th century onwards, scientific research, especially in the field of the Natural Sciences, has grown into a more and more complex practice, which often entangles very special needs, in terms of research objects, techniques, sources, and perspectives. A few special places, such as the Stazione Zoologica di Napoli, have represented in this period the focal points of an ever growing international scientific network, promoting independent research, exchange and diffusion of novel practices and techniques and unrestricted confrontation. The so-called "Naples experience" has been cited by a large number of renowned scientists of the last two centuries as a key moment in their scientific life. Here we have tried to test it against the experience of three great scientists par excellence, i.e. three Nobel laureates (T. H. Morgan, Otto Warburg, J. D. Watson). The different experiences they have had at Naples represent, in our view, three different moments of the professional life of almost every scientist. Therefore, we have chosen to present them as a phenomenology. The final section is dedicated to a survey of the Zoological Station's contribution to neurosciences, especially to the Naples experience of the Nobel Prize winner Sir Bernard Katz and his assistant Ricardo Miledi, between 1965 and 1970. Their work on the squid at Naples allowed probing and quantitative refinement of results already obtained on different animals and contributed to reinforce the long lasting neurophysiological tradition of the institute.

  20. ACTA Technology Presents EPA with Patent Copy

    EPA Pesticide Factsheets

    US EPA SBIR awardee, ACTA Technology, presented James H. Johnson, Director of the US EPA National Center for Environmental Research, and April Richards, Program Manager of the US EPA's SBIR Program, with a copy of their Red Ribbon patent.

  1. 50th Anniversary of Acta stomatologica Croatica

    PubMed Central

    2016-01-01

    Summary Acta stomatologica Croatisa (ASCRO) is scientific-professional magazine whose first issue was published back in 1966. Ever since the magazine publishers were the School of Dental Medicine of the University of Zagreb and the Croatian Dental Association of the Croatian Medical Association. Over the past fifty years two hundred regular editions were pubslihed along with three additions. The magazine has been internationally indexed and it was granted the DOI number. In this way by means of CrossCheck possible plagiarisms are being checked which aims at obtaining originality of the published results. Another peculiarity of ASCRO is bilingualism throughout the whole edition, international recognizability, open source and tradition based on sound foundations. PMID:27688420

  2. Entering the 60th year of Acta Astronautica

    NASA Astrophysics Data System (ADS)

    Chang, Yi-Wei; Chern, Jeng-Shing; Marec, Jean-Pierre

    2014-04-01

    The Acta Astronautica Journal was firstly published in 1955 as the official Journal of the International Astronautical Federation (IAF) with the title Astronautica Acta. It is entering its 60th year in 2014. In 1962, the Astronautica Acta became the official Journal of the International Academy of Astronautics (IAA) established in 1960. A total of 18 volumes had been published from 1955 to 1973 under the leadership of three Editor-in-Chiefs: F. Hecht, Theodore von Karman, and Martin Summerfield. In 1974, A.K. Oppenheim became the new Editor-in-Chief and several evolved changes were performed including change of the title to Acta Astronautica (for grammatical correctness), cover page change, and format change. From 1974 to 2010, another three Editor-in-Chiefs led the journal with 67 volumes published. They were A.K. Oppenheim, Jean-Pierre Marec, and Rupert Gerzer. The current Editor-in-Chief Jeng-Shing Chern (Rock) took over the job from 2011. Total pages and articles published in 2012 are 3586 and 356, respectively. Currently, the Acta Astronautica Editorial Board consists of one Editor-in-Chief, 15 Co-Editors, one Managing Editor and one Honorary Editor-in-Chief (Jean-Pierre Marec). After 59 years, the Acta Astronautica has become a well-known journal worldwide. Its current rank and impact factor are 7/63 and 0.701, respectively. This paper presents some of the details as well as new strategies and steps. In particular, supports from the IAA Academicians are mandatory and most welcome.

  3. Elsevier/Spectrochimica Acta Atomic Spectroscopy Award 2014

    NASA Astrophysics Data System (ADS)

    Omenetto, Nicolo'; de Loos, Greet

    2016-03-01

    This is to announce the 2014 Elsevier/Spectrochimica Acta Award, the annual award honoring the most significant article(s) published in a volume. Elsevier makes this award on behalf of Spectrochimica Acta, Part B, to encourage the publication of top articles in this journal. All papers published during one year are considered for this award and the Editorial Advisory Board and the Guest Editor(s) of the special issue(s) are responsible for the selection. The award consists of a monetary prize of 1000 together with a presentation certificate.

  4. Elsevier/Spectrochimica Acta atomic spectroscopy award 2015

    NASA Astrophysics Data System (ADS)

    Omenetto, Nicolo; de Loos-Vollebregt, Margaretha

    2016-12-01

    This is to announce the 2015 Elsevier/Spectrochimica Acta award, the annual award honoring the most significant article(s) published in a volume. Elsevier makes this award on behalf of Spectrochimica Acta, Part B, to encourage the publication of top articles in this journal. All papers published during one year are considered for this award and the Editorial Advisory Board and the Guest Editor(s) of the special issue(s) are responsible for the selection. The award consists of a monetary prize of 1000 together with a presentation certificate.

  5. Elsevier/Spectrochimica Acta Atomic Spectroscopy Award 2013

    NASA Astrophysics Data System (ADS)

    Omenetto, Nicolo'; de Loos, Greet

    2015-01-01

    This is to announce the 2013 Elsevier/Spectrochimica Acta Award, the annual award honoring the most significant article(s) published in a volume. Elsevier makes this award on behalf of Spectrochimica Acta, Part B, to encourage the publication of top articles in this journal. All papers published during one year are considered for this award and the Editorial Advisory Board and the Guest Editor(s) of the special issue(s) are responsible for the selection. The award consists of a monetary prize of 1000 together with a presentation certificate.

  6. Advertising in Actas Dermosifiliográficas, 1909-1939.

    PubMed

    Díaz-Díaz, R M

    2014-05-01

    We review advertisements published in the journal Actas Dermosifiliográficas between 1909 and 1939. Treatments for sexually transmitted diseases were advertised with particular frequency, and they offer a case in point that exemplifies the close relationship between the pharmaceutical industry and medical journals.

  7. Identification and expression pattern of candidate olfactory genes in Chrysoperla sinica by antennal transcriptome analysis.

    PubMed

    Li, Zhao-Qun; Zhang, Shuai; Luo, Jun-Yu; Wang, Si-Bao; Wang, Chun-Yi; Lv, Li-Min; Dong, Shuang-Lin; Cui, Jin-Jie

    2015-09-01

    Chrysoperla sinica is one of the most prominent natural enemies of many agricultural pests. Host seeking in insects is strongly mediated by olfaction. Understanding the sophisticated olfactory system of insect antennae is crucial for studying the physiological bases of olfaction and could also help enhance the effectiveness of C. sinica in biological control. Obtaining olfactory genes is a research priority for investigating the olfactory system in this species. However, no olfaction sequence information is available for C. sinica. Consequently, we sequenced female- and male-antennae transcriptome of C. sinica. Many candidate chemosensory genes were identified, including 12 odorant-binding proteins (OBPs), 19 chemosensory proteins (CSPs), 37 odorant receptors (ORs), and 64 ionotropic receptors from C. sinica. The expression patterns of 12 OBPs, 19 CSPs and 37 ORs were determined by RT-PCR, and demonstrated antennae-dominantly expression of most OBP and OR genes. Our finding provided large scale genes for further investigation on the olfactory system of C. sinica at the molecular level.

  8. Aortic Disease Presentation and Outcome Associated with ACTA2 mutations

    PubMed Central

    Regalado, Ellen S.; Guo, Dongchuan; Prakash, Siddharth; Bensend, Tracy A.; Flynn, Kelly; Estrera, Anthony; Safi, Hazim; Liang, David; Hyland, James; Child, Anne; Arno, Gavin; Boileau, Catherine; Jondeau, Guillaume; Braverman, Alan; Moran, Rocio; Morisaki, Takayuki; Morisaki, Hiroko; Consortium, Montalcino Aortic; Pyeritz, Reed; Coselli, Joseph; LeMaire, Scott; Milewicz, Dianna M.

    2015-01-01

    Background ACTA2 mutations are the major cause of familial thoracic aortic aneurysms and dissections. We sought to characterize these aortic diseases in a large case series of individuals with ACTA2 mutations. Methods and Results Aortic disease, management, and outcome associated with the first aortic event (aortic dissection or aneurysm repair) were abstracted from the medical records of 277 individuals with 41 various ACTA2 mutations. Aortic events occurred in 48% of these individuals, with the vast majority presenting with thoracic aortic dissections (88%) associated with 25% mortality. Type A dissections were more common than type B dissections (54% versus 21%), but the median age of onset of type B dissections was significantly younger than type A dissections (27 years, IQR 18–41 versus 36 years, IQR 26–45). Only 12% of aortic events were repair of ascending aortic aneurysms, which variably involved the aortic root, ascending aorta and aortic arch. Overall cumulative risk of an aortic event at age 85 years was 0.76 (95% CI 0.64, 0.86). After adjustment for intra-familial correlation, gender and race, mutations disrupting p.R179 and p.R258 were associated with significantly increased risk for aortic events, whereas p.R185Q and p.R118Q mutations showed significantly lower risk of aortic events compared to other mutations. Conclusions ACTA2 mutations are associated with high risk of presentation with an acute aortic dissection. The lifetime risk for an aortic event is only 76%, suggesting that additional environmental or genetic factors play a role in expression of aortic disease in individuals with ACTA2 mutations. PMID:25759435

  9. Cerebral arteriopathy associated with Arg179His ACTA2 mutation

    PubMed Central

    Amans, Matthew R; Stout, Charles; Fox, Christine; Narvid, Jared; Hetts, Steven W; Cooke, Daniel L; Higashida, Randall T; Dowd, Christopher F; McSwain, Hugh; Halbach, Van V

    2013-01-01

    ACTA2 mutations have recently been shown to cause a multisystem smooth muscle dysfunction syndrome that may result in pediatric stroke. We report a case of ACTA2 mutation in a 3-year-old girl presenting with acute ischemic stroke and provide high resolution imaging of the cerebral arteries demonstrating novel findings of multiple tiny aneurysms (particularly in the posterior circulation), as well as the more characteristic imaging phenotype of straightened and narrowed proximal intracranial vessels, dilated cervical vessels and occlusion of the M1 MCA segment without lenticulostriate collateral formation. This newly identified disease should be added to the differential diagnosis of pediatric stroke and cerebral vasculopathy. Neuroradiologists, interventionalists, surgeons and neurologists should become familiar with this rare disease and its clinical sequelae. PMID:24293535

  10. Composition and stereochemistry of ephedrine alkaloids accumulation in Ephedra sinica Stapf.

    PubMed

    Krizevski, Raz; Bar, Einat; Shalit, Or; Sitrit, Yaron; Ben-Shabat, Shimon; Lewinsohn, Efraim

    2010-06-01

    Ephedra sinica Stapf (Ephedraceae) is a widely used Chinese medicinal plant (Chinese name: Ma Huang). The main active constituents of E. sinica are the unique and taxonomically restricted adrenergic agonists phenylpropylamino alkaloids, also known as ephedrine alkaloids: (1R,2S)-norephedrine (1S,2S)-norpseudoephedrine, (1R,2S)-ephedrine, (1S,2S)-pseudoephedrine, (1R,2S)-N-methylephedrine and (1S,2S)-N-methylpseudoephedrine. GC-MS analysis of freshly picked young E. sinica stems enabled the detection of 1-phenylpropane-1,2-dione and (S)-cathinone, the first two putative committed biosynthetic precursors to the ephedrine alkaloids. These metabolites are only present in young E. sinica stems and not in mature stems or roots. The related Ephedra foemina and Ephedra foliata also lack ephedrine alkaloids and their metabolic precursors in their aerial parts. A marked diversity in the ephedrine alkaloids content and stereochemical composition in 16 different E. sinica accessions growing under the same environmental conditions was revealed, indicating genetic control of these traits. The accessions can be classified into two groups according to the stereochemistry of the products accumulated: a group that displayed only 1R stereoisomers, and a group that displayed both 1S and 1R stereoisomers. (S)-cathinone reductase activities were detected in E. sinica stems capable of reducing (S)-cathinone to (1R,2S)-norephedrine and (1S,2S)-norpseudoephedrine in the presence of NADH. The proportion of the diastereoisomers formed varied according to the accession tested. A (1R,2S)-norephedrine N-methyltransferase capable of converting (1R,2S)-norephedrine to (1R,2S)-ephedrine in the presence of S-adenosylmethionine (SAM) was also detected in E. sinica stems. Our studies further support the notion that 1-phenylpropane-1,2-dione and (S)-cathinone are biosynthetic precursors of the ephedrine alkaloids in E. sinica stems and that the activity of (S)-cathinone reductases directs and

  11. Cardiac α-actin over-expression therapy in dominant ACTA1 disease.

    PubMed

    Ravenscroft, Gianina; McNamara, Elyshia; Griffiths, Lisa M; Papadimitriou, John M; Hardeman, Edna C; Bakker, Anthony J; Davies, Kay E; Laing, Nigel G; Nowak, Kristen J

    2013-10-01

    More than 200 mutations in the skeletal muscle α-actin gene (ACTA1) cause either dominant or recessive skeletal muscle disease. Currently, there are no specific therapies. Cardiac α-actin is 99% identical to skeletal muscle α-actin and the predominant actin isoform in fetal muscle. We previously showed cardiac α-actin can substitute for skeletal muscle α-actin, preventing the early postnatal death of Acta1 knock-out mice, which model recessive ACTA1 disease. Dominant ACTA1 disease is caused by the presence of 'poison' mutant actin protein. Experimental and anecdotal evidence nevertheless indicates that the severity of dominant ACTA1 disease is modulated by the relative amount of mutant skeletal muscle α-actin protein present. Thus, we investigated whether transgenic over-expression of cardiac α-actin in postnatal skeletal muscle could ameliorate the phenotype of mouse models of severe dominant ACTA1 disease. In one model, lethality of ACTA1(D286G). Acta1(+/-) mice was reduced from ∼59% before 30 days of age to ∼12%. In the other model, Acta1(H40Y), in which ∼80% of male mice die by 5 months of age, the cardiac α-actin transgene did not significantly improve survival. Hence cardiac α-actin over-expression is likely to be therapeutic for at least some dominant ACTA1 mutations. The reason cardiac α-actin was not effective in the Acta1(H40Y) mice is uncertain. We showed that the Acta1(H40Y) mice had endogenously elevated levels of cardiac α-actin in skeletal muscles, a finding not reported in dominant ACTA1 patients.

  12. Langkocyclines: novel angucycline antibiotics from Streptomyces sp. Acta 3034(*).

    PubMed

    Kalyon, Bahar; Tan, Geok-Yuan A; Pinto, John M; Foo, Cheau-Yee; Wiese, Jutta; Imhoff, Johannes F; Süssmuth, Roderich D; Sabaratnam, Vikineswary; Fiedler, Hans-Peter

    2013-10-01

    Langkocyclines A1-A3 and B1 and B2, five new angucycline antibiotics produced by Streptomyces sp. Acta 3034, were detected in the course of our HPLC-diode array screening. The producing strain was isolated from the rhizospheric soil of a Clitorea sp. collected from Burau Bay, Langkawi, Malaysia, and was characterized by morphological, physiological and chemotaxonomic features in addition to 16S ribosomal RNA gene sequence information. Strain Acta 3034 is closely related to Streptomyces psammoticus NBRC 13971(T) and Streptomyces lanatus NBRC 12787(T). Langkocyclines consist of an angular tetracyclic benz[a]anthracene skeleton and hydrolyzable O-glycosidic sugar moieties. The yellow-colored A-type langkocyclines differ in their aglycon from the blue-lilac-colored B-type langkocyclines. The A-type langkocycline aglycon is identical to that of aquayamycin and urdamycin A. The chemical structures of the langkocyclines were elucidated by HR-MS, 1D and 2D NMR experiments. They are biologically active against Gram-positive bacteria and exhibit a moderate antiproliferative activity against various human tumor cell lines.

  13. Electromagnetic separation of stable isotopes at the Institute of Atomic Energy, Academia Sinica

    NASA Astrophysics Data System (ADS)

    Ming-da, Hua; Gong-pan, Li; Shi-jun, Su; Nai-feng, Mao; Hung-yung, Lu

    1981-07-01

    For almost 20 years the Institute of Atomic Energy, Academia Sinica has been separating stable isotopes of the elements by electromagnetic separators and supplying these materials to research work in many fields of our country. In this article we shall attempt to outline the growth of the effort and describe the present situation.

  14. Activity of Bacillus thuringiensis against Pryeria sinica(Lepidoptera: Zygaenidae), an invasive pest of Euonymus

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Pryeria sinica Moore (Lepidoptera: Zygaenidae), an invasive pest of Euonymus, is susceptible in the second instar to the Bacillus thuringiensis Berliner product Thuricide®, and to several strains isolated from other B. thuringiensis products. Third instars are also susceptible, while susceptibility...

  15. Acta stomatologica Croatica and PubMed Central

    PubMed Central

    Brkić, Hrvoje

    2016-01-01

    April 15 2016 marked the 50th anniversary of continuous publishing of the journal Acta stomatologica Croatica (ASCRO). The celebration was held in the great hall of the Croatian Medical Association, with numerous guests from the biomedical field. The history of the journal was presented by Goran Knežević (editor-in-chief 1996-2006) and Hrvoje Brkić (current editor-in-chief), who presented all the current information on the electronical editing and its current indexation. Only a few days later, the Editorial Office received the information that ASCRO has been included in PubMed Central since volume 48, an impulse for the members of the Editorial Board and the Editor-in-Chief to make ASCRO better and more cited PMID:27789906

  16. Caragasinin C: a new oligostilbene from the roots of Caragana sinica.

    PubMed

    Jeong, Wonsik; Ahn, Eun-Kyung; Oh, Joa Sub; Hong, Seong Su

    2017-03-28

    A new oligostilbene, caragasinin C (1), and seven known compounds, betulinic acid (2), 4-hydroxybenzaldehyde (3), (‒)-medicarpin (4), wistin (5), (2E,4S)-4-hydroxy-2-nonenoic acid (6), pallidol (7), and (+)-α-viniferin (8), were isolated from the roots of Caragana sinica. The structure of caragasinin C was established on the basis of spectroscopic techniques, including HRESIMS, 1D and 2D-NMR.

  17. Acta Clinica Croatica: progress of a journal step by step.

    PubMed

    Ramljak, Gordana

    2014-03-01

    The journal Acta Clinica Croatica (ACC) was founded in 1962 under the title Anali Bolnice Dr. M. Stojanović. In 1995, the title of the journal was changed into its present form and ever since all papers have been published in English. In 2000, the electronic (online) edition of the ACC was released in addition to the print version. The paper presents development of the journal from 1962 to 2012 based on the analysis of the following SCOPUS citation index parameters: type and number of documents published in the journal; number of citations; and number of domestic and foreign authors. The studied period was analyzed in three time segments: the period from 1995 to 1999, the period from 2000 to 2006 and the period from 2007 to 2012. The same parameters were analyzed in the Web of Science/SCI-Expanded bibliographic and citation index for the 2007-2012 period. The increasing number of documents, authors (both domestic and foreign) and citations demonstrates gradual rise in the quality, visibility and impact of the journal. The fifty years of experience show that a goal, at first very distant and almost unachievable, may be reached by progressing step by step.

  18. Acta informatica medica is indexed in pubmed and archived in pubmed central.

    PubMed

    Masic, Izet

    2013-03-01

    Acta Informatica Medica journal has been accepted for archiving in PubMed Central from 2011 onward. The journal started in 1993 as the official journal of the Society for Medical Informatics of Bosnia and Herzegovina. During the last 3 years, Acta Informatica Medica has een included in almost all prestigious online databases, including PubMed, Scopus and EMBASE. The 20th volume of the journal is fully international, with papers from 18 countries.

  19. Acute aortic dissections with pregnancy in women with ACTA2 mutations.

    PubMed

    Regalado, Ellen S; Guo, Dong-chuan; Estrera, Anthony L; Buja, L Maximilian; Milewicz, Dianna M

    2014-01-01

    Mutations in ACTA2 predispose to thoracic aortic aneurysms and dissection as well as coronary artery and cerebrovascular disease. Here we examined the risk of aortic dissections, stroke and myocardial infarct with pregnancy in women with ACTA2 mutations. Of the 53 women who had a total of 137 pregnancies, eight had aortic dissections in the third trimester or the postpartum period (6% of pregnancies). One woman also had a myocardial infarct that occurred during pregnancy that was independent of her aortic dissection. Compared to the population-based frequency of peripartum aortic dissections of 0.6%, the rate of peripartum aortic dissections in women with ACTA2 mutations is much higher (8 out of 39; 20%). Six of these dissections initiated in the ascending aorta (Stanford type A), three were fatal. Three women had ascending aortic dissections at diameters less that 5.0 cm (range 3.8-4.7 cm). Aortic pathology showed mild to moderate medial degeneration of the aorta in three women. Of note, five of the women had hypertension either during or before the pregnancy. In summary, the majority of women with ACTA2 mutations did not have aortic or other vascular complications with pregnancy. However, these findings show that pregnancy is associated with significant risk for aortic dissection in women with ACTA2 mutations. Women with ACTA2 mutations who are planning to get pregnant should be counseled about this risk of aortic dissection, and proper clinical management should be initiated to reduce this risk.

  20. Beneficial effect of dietary Ephedra sinica on obesity and glucose intolerance in high-fat diet-fed mice

    PubMed Central

    SONG, MOON-KOO; UM, JAE-YOUNG; JANG, HYEUNG-JIN; LEE, BYUNG-CHEOL

    2012-01-01

    Obesity is a major contributor to both glucose intolerance and metabolic syndrome. In this study, we investigated the anti-obesity and anti-hyperglycemic effects of Ephedra sinica on high-fat diet-fed mice. Male ICR mice were divided into four groups; the normal group, the obese and diabetic control group treated with a high-fat diet, the positive control group treated with a high-fat diet containing acarbose, and the experimental group treated with a high-fat diet containing Ephedra sinica. The effects of Ephedra sinica on obesity and glucose intolerance were measured by an oral glucose tolerance test (OGTT), plasma biochemistry, body and epididymal fat weight; the expression of adiponectin, peroxisome-proliferator-activated receptor α (PPAR-α), tumor necrosis factor α (TNF-α) and leptin was also determined. Ephedra sinica reduced weight gain and epididymal fat accumulation, improved glucose intolerance on the OGTT, decreased triglycerides and increased high-density lipoprotein cholesterol compared to the controls. Moreover, it reduced weight gain and fasting glucose levels and improved HDL-cholesterol levels more than acarbose. Gene expression analysis revealed that Ephedra sinica upregulated the expression of adiponectin and PPAR-α, and downregulated the expression of TNF-α. From these results, we suggest that Ephedra sinica may reduce obesity and hyperglycemia by increasing PPAR-α and adiponectin and reducing TNF-α, and that it may have the potential to be used clinically as an ingredient in food or drugs effective in obesity-related glucose intolerance treatments. PMID:22969956

  1. Anti-hepatoma activities of ethyl acetate extract from Ampelopsis sinica root.

    PubMed

    Wang, Jia-Zhi; Huang, Bi-Sheng; Cao, Yan; Chen, Ke-Li; Li, Juan

    2017-03-13

    Ampelopsis sinica root (ASR) is a known hepatoprotective folk traditional Chinese medicine. The anti‑hepatoma activity of ethyl acetate extract from A. sinica root (ASRE) in vitro and in vivo and its possible mechanism were explored. This study was designed to investigate cytotoxicity by MTT assay, induction of apoptosis via Hoechst 33258 staining, scanning electron microscopy and bivariate flow cytometric analysis (Annexin V-FITC/PI), inflammation and apoptosis related genes expression by RT-PCR and p53 protein expression by immunofluorescence assay in HepG2 cells. Then, the antitumor activity in vivo was detected by hepatoma H22 xenograft tumor in mice. The results showed that ASRE had powerful anti‑hepatoma activity in vitro without obvious toxicity on normal cells and could induce HepG2 cell apoptosis. The mechanism may be associated with downregulation of inflammatory cytokines including cyclooxygenase-2, 5-lipoxygenase and FLAP, increase of the ratio of bax/bcl-2, activation caspase-3 and inhibition of survivin, and increased expression of p53 protein. Furthermore, the HPLC assay showed the main compounds of ASRE were gallic acid, catechin and gallic acid ethyl ester. In animal experiments, ASR ethanol extract decreased the tumor weights of hepatoma H22 tumor-bearing mice. Therefore, ASR may be a potential therapeutic agent in the treatment of hepatocellular carcinoma.

  2. Bacterial Shape and ActA Distribution Affect Initiation of Listeria monocytogenes Actin-Based Motility

    PubMed Central

    Rafelski, Susanne M.; Theriot, Julie A.

    2005-01-01

    We have examined the process by which the intracellular bacterial pathogen Listeria monocytogenes initiates actin-based motility and determined the contribution of the variable surface distribution of the ActA protein to initiation and steady-state movement. To directly correlate ActA distributions to actin dynamics and motility of live bacteria, ActA was fused to a monomeric red fluorescent protein (mRFP1). Actin comet tail formation and steady-state bacterial movement rates both depended on ActA distribution, which in turn was tightly coupled to the bacterial cell cycle. Motility initiation was found to be a highly complex, multistep process for bacteria, in contrast to the simple symmetry breaking previously observed for ActA-coated spherical beads. F-actin initially accumulated along the sides of the bacterium and then slowly migrated to the bacterial pole expressing the highest density of ActA as a tail formed. Early movement was highly unstable with extreme changes in speed and frequent stops. Over time, saltatory motility and sensitivity to the immediate environment decreased as bacterial movement became robust at a constant steady-state speed. PMID:15980176

  3. Beitraege zur Astronomiegeschichte, Band 5 (Acta Historica Astronomiae Vol. 18)

    NASA Astrophysics Data System (ADS)

    Duerbeck, H. W.; Dick, W. R.; Hamel, J.

    2003-01-01

    The 18th volume of the Acta Historica Astronomiae is at the same time the sixth collection of essays on the history of astronomy ("Beitræge zur Astronomiegeschichte, Band 6"), edited by the historians of astronomy W.R. Dick (Potsdam) and J. Hamel (Berlin). Besides a few short notices and book reviews, the book contains eight major articles, which deal with astronomical topics covering the time from the 16th to the 19th centuries. The first article by Michael Weichenhan (Berlin) deals with "the invention of the disk-shaped earth: a chapter of Copernican apologetics". The author shows that the concept of a "disc-shaped Earth" was by no means widespread in the middle ages, but restricted to the father of the church Lactantius and some adherents. Nevertheless, it was used by adherents of Copernicus to show the absurd consequences of a strictly literal biblical interpretation -- here concerning the Earth's shape, disc versus sphere, there the geocentric versus the heliocentric system. This thorough philosophical study is followed by two very short articles. "The measuring accuracy of Tycho's large sextant" by Johann Wünsch investigates O-C values of planet-star distances, as based on Tycho's observations as published in the Historia Coelestis (a compilation, which is also based on Tycho's manuscripts, and published in Regensburg in 1672). The result is that standard deviations are 80 arcseconds for Saturn and 89 arcseconds for Jupiter and Mars, an unexpectedly poor result in view of the general opinion that Tycho was famous for his precision work. "The astronomer Christoph Grienberger and the Galilei trial" by Franz Daxecker deals with a Jesuit astronomer who was both the disciple and successor of the mathematician-astronomer Christopher Clavius at the Collegium Romanum. While he was inclined to Galilei early on, he was forced to propagate Aristotelian doctrine. The brief article is very concise, but extremely tiresome to read (3 pages of pure text are embellished by

  4. The euonymus leaf-notcher, Pryeria sinica Moore (Lepidoptera: Zygaenidae) - alive and well in Fairfax County, Virginia

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Pryeria sinica Moore, a species native to the eastern Palearctic, was first detected in North America in 2001, where the conspicuous, gregariously-feeding larvae were noticed on ornamental Euonymous (Celastraceae) in a residential area of Fairfax County, Virginia. Although the species was moderatel...

  5. Acta Dermatovenerologica Alpina, Pannonica et Adriatica accepted for coverage in Thomson Reuters' Emerging Sources Citation Index (ESCI).

    PubMed

    Poljak, Mario; Miljković, Jovan; Triglav, Tina

    2016-09-01

    Acta Dermatovenerologica Alpina, Pannonica et Adriatica (Acta Dermatovenerol APA) is the leading journal in dermatology and sexually transmitted infections in the region. Several important steps were taken during the last 25 years to improve the journal's quality, global visibility, and international impact. After a 1-year trial period, Thomson Reuters recently informed the editorial office that they had accepted Acta Dermatovenerol APA for coverage in Thomson Reuters' new index in the Web of Science Core Collection called the Emerging Sources Citation Index (ESCI). The coverage of Acta Dermatovenerol APA begins with the journal content published online in 2016; that is, from volume 25 onwards.

  6. Acute Aortic Dissections with Pregnancy in Women with ACTA2 Mutations

    PubMed Central

    Regalado, Ellen S.; Guo, Dong-chuan; Estrera, Anthony L.; Buja, L. Maximilian; Milewicz, Dianna M.

    2014-01-01

    Mutations in ACTA2 predispose to thoracic aortic aneurysms and dissections as well as coronary artery and cerebrovascular disease. Here we examined the risk of aortic dissections, stroke and myocardial infarct with pregnancy in women with ACTA2 mutations. Of the 53 women who had a total of 137 pregnancies, eight had aortic dissections in the third trimester or the postpartum period (6% of pregnancies). One woman also had a myocardial infarct that occurred during pregnancy that was independent of her aortic dissection. Compared to the population-based frequency of peripartum aortic dissections of 0.6%, the rate of peripartum aortic dissections in women with ACTA2 mutations is much higher (8 out of 39; 20%). Six of these dissections initiated in the ascending aorta (Stanford type A), three of which were fatal. Three women had ascending aortic dissections at diameters less that 5.0 cm (range 3.8 to 4.7 cm). Aortic pathology showed mild to moderate medial degeneration of the aorta in three women. Of note, five of the women had hypertension either during or before the pregnancy. In summary, the majority of women with ACTA2 mutations did not have aortic or other vascular complications with pregnancy. However, these findings show that pregnancy is associated with significant risk for aortic dissections in women in whom diagnosis of ACTA2 mutation has not been made. Women with ACTA2 mutations who are planning to get pregnant should be counseled about this risk of aortic dissections, and proper clinical management should be initiated to reduce this risk. PMID:24243736

  7. A novel distinctive cerebrovascular phenotype is associated with heterozygous Arg179 ACTA2 mutations

    PubMed Central

    Munot, Pinki; Saunders, Dawn E.; Milewicz, Dianna M.; Regalado, Ellen S.; Ostergaard, John R.; Braun, Kees P.; Kerr, Timothy; Lichtenbelt, Klaske D.; Philip, Sunny; Rittey, Christopher; Jacques, Thomas S.; Cox, Timothy C.

    2012-01-01

    Mutations in the ACTA2 gene lead to diffuse and diverse vascular diseases; the Arg179His mutation is associated with an early onset severe phenotype due to global smooth muscle dysfunction. Cerebrovascular disease associated with ACTA2 mutations has been likened to moyamoya disease, but appears to have distinctive features. This study involved the analysis of neuroimaging of 13 patients with heterozygous missense mutations in ACTA2 disrupting Arg179. All patients had persistent ductus arteriosus and congenital mydriasis, and variable presentation of pulmonary hypertension, bladder and gastrointestinal problems associated with this mutation. Distinctive cerebrovascular features were dilatation of proximal internal carotid artery, occlusive disease of terminal internal carotid artery, an abnormally straight course of intracranial arteries, and absent basal ‘moyamoya’ collaterals. Patterns of brain injury supported both large and small vessel disease. Key differences from moyamoya disease were more widespread arteriopathy, the combination of arterial ectasia and stenosis and, importantly, absence of the typical basal ‘moyamoya’ collaterals. Evaluation of previously published cases suggests some of these features are also seen in the ACTA2 mutations disrupting Arg258. The observation that transition from dilated to normal/stenotic arterial calibre coincides with where the internal carotid artery changes from an elastic to muscular artery supports the hypothesis that abnormal smooth muscle cell proliferation caused by ACTA2 mutations is modulated by arterial wall components. Patients with persistent ductus arteriosus or congenital mydriasis with a label of ‘moyamoya’ should be re-evaluated to ensure the distinctive neuroimaging features of an ACTA2 mutation have not been overlooked. This diagnosis has prognostic and genetic implications, and mandates surveillance of other organ systems, in particular the aorta, to prevent life-threatening aortic dissection

  8. De Novo ACTA2 Mutation Causes a Novel Syndrome of Multisystemic Smooth Muscle Dysfunction

    PubMed Central

    Milewicz, Dianna M.; Østergaard, John R.; Ala-Kokko, Leena M.; Khan, Nadia; Grange, Dorothy K.; Mendoza-Londono, Roberto; Bradley, Timothy J.; Olney, Ann Haskins; Adès, Lesley; Maher, Joseph F.; Guo, Dongchuan; Buja, L. Maximilian; Kim, Dong; Hyland, James C.; Regalado, Ellen S.

    2011-01-01

    Smooth muscle cells (SMCs) contract to perform many physiological functions, including regulation of blood flow and pressure in arteries, contraction of the pupils, peristalsis of the gut and voiding of the bladder. SMC lineage in these organs is characterized by cellular expression of the SMC isoform of α-actin, encoded by the ACTA2 gene. We report here on a unique and de novo mutation in ACTA2, R179H, that causes a syndrome characterized by dysfunction of SMCs throughout the body, leading to aortic and cerebrovascular disease, fixed dilated pupils, hypotonic bladder, malrotation and hypoperistalsis of the gut and pulmonary hypertension. PMID:20734336

  9. Identification of the glycerol kinase gene and its role in diapause embryo restart and early embryo development of Artemia sinica.

    PubMed

    Cheng, Cheng; Yao, Feng; Chu, Bing; Li, Xuejie; Liu, Yan; Wu, Yang; Mei, Yanli; Wang, Peisheng; Hou, Lin; Zou, Xiangyang

    2014-03-01

    Glycerol kinase (GK) catalyzes the rate-limiting step in glycerol utilization by transferring a phosphate from ATP to glycerol, yielding glycerol 3-phosphate, which is an important intermediate for both energy metabolism and glycerolipid production. Artemia sinica has an unusual diapause process under stress conditions of high salinity, low temperature and lack of food. In the process, diapause embryos of A. sinica (brine shrimp) accumulate high concentrations of glycerol as a cryoprotectant to prevent low temperature damage to embryos. Upon embryo restart, glycerol is converted into glucose and other carbohydrates. Therefore, GK plays an important role in the diapause embryo restart process. However, the role of GK in diapause termination of embryo development in A. sinica remains unknown. In the present study, a 2096 bp full-length cDNA of gk from A. sinica (As-gk) was obtained, encoding putative 551 amino acids, 60.6 kDa protein. As a crucial enzyme in glycerol uptake and metabolism, GK has been conserved structurally and functionally during evolution. The expression pattern of As-gk was investigated by quantitative real-time PCR and Western blotting. Expression locations of As-gk were analyzed using in situ hybridization. As-gk was widely distributed in the early embryo and several main parts of Artemia after differentiation. The expression of As-GK was also induced by stresses such as cold exposure and high salinity. This initial research into the expression pattern and stress response of GK in Artemia provides a sound basis for further understanding of the function and regulation of genes in early embryonic development in A. sinica and the stress response.

  10. [Studies on chemical constituents from the root of Coriaria nepalensis wall (Coriaria sinica Maxim)].

    PubMed

    Wei, H; Zeng, F; Lu, M; Tang, R

    1998-09-01

    The root of Coriaria nepalensis Wall (Coriaria sinica Maxim) is a Chinese herbal medicine and has been used to treat numbness, toothache due to wind and heat, phlegm-retention syndrome, traumatic injury and acute conjunctivitis. Nine compounds were isolated from the root of Coriaria nepalensis Wall and they were identified as braylin (I), norbraylin (II), dihydrocoriamyrtin (III), coriamyrtin (IV), tutin (V), coriatin (VI), apotutin (VII), hydroxycoriatin (VIII) and gallic acid (IX) on the basis of their physicochemical properties and IR, UV, MS, 1HNMR, 13CNMR data. I, II were isolated from the title plant for the first time; III was obtained from plant origin for the first time, and VII, VIII were new compounds.

  11. Neutron therapy facility at the Institute of High Energy Physics, Academia Sinica

    SciTech Connect

    Zhu, Y.C.

    1983-12-01

    The 10 MeV proton linac which was designed as preinjector for the Beijing 50 GeV Proton Synchrotron (BPS) was completed by the end of 1982. Because of the economic readjustment in the People's Republic of China the BPS project was cancelled. Then, the Institute of High Energy Physics decided to increase the energy of the linac from 10 MeV to 35.5 MeV. This increase will take place using the primary five megawatts RF system of the 10 MeV linac. This 35.5 MeV proton linac will be used for research in radiomedicine and radiobiology in general and in particular for research in fast neutron therapy and radiopharmaceutical production. This project has been approved by the Academia Sinica.

  12. Physiological characteristics of the anaerobic ammonium-oxidizing bacterium 'Candidatus Brocadia sinica'.

    PubMed

    Oshiki, Mamoru; Shimokawa, Masaki; Fujii, Naoki; Satoh, Hisashi; Okabe, Satoshi

    2011-06-01

    The present study investigated the phylogenetic affiliation and physiological characteristics of bacteria responsible for anaerobic ammonium oxidization (anammox); these bacteria were enriched in an anammox reactor with a nitrogen removal rate of 26.0 kg N m(-3) day(-1). The anammox bacteria were identified as representing 'Candidatus Brocadia sinica' on the basis of phylogenetic analysis of rRNA operon sequences. Physiological characteristics examined were growth rate, kinetics of ammonium oxidation and nitrite reduction, temperature, pH and inhibition of anammox. The maximum specific growth rate (μ(max)) was 0.0041 h(-1), corresponding to a doubling time of 7 days. The half-saturation constants (K(s)) for ammonium and nitrite of 'Ca. B. sinica' were 28±4 and 86±4 µM, respectively, higher than those of 'Candidatus Brocadia anammoxidans' and 'Candidatus Kuenenia stuttgartiensis'. The temperature and pH ranges of anammox activity were 25-45 °C and pH 6.5-8.8, respectively. Anammox activity was inhibited in the presence of nitrite (50 % inhibition at 16 mM), ethanol (91 % at 1 mM) and methanol (86 % at 1 mM). Anammox activities were 80 and 70 % of baseline in the presence of 20 mM phosphorus and 3 % salinity, respectively. The yield of biomass and dissolved organic carbon production in the culture supernatant were 0.062 and 0.005 mol C (mol NH (+)(-4))(-1), respectively. This study compared physiological differences between three anammox bacterial enrichment cultures to provide a better understanding of anammox niche specificity in natural and man-made ecosystems.

  13. Simple, rapid and effective preservation and reactivation of anaerobic ammonium oxidizing bacterium "Candidatus Brocadia sinica".

    PubMed

    Ali, Muhammad; Oshiki, Mamoru; Okabe, Satoshi

    2014-06-15

    It is still the biggest challenge to secure enough seeding biomass for rapid start-up of full-scale (anaerobic ammonium oxidation) anammox processes due to slow growth. Preservation of active anammox biomass could be one of the solutions. In this study, biomass of anammox bacterium, "Candidatus Brocadia sinica", immersed in various nutrient media were preserved at -80 °C, 4 °C and room temperature. After 45, 90 and 150 days of preservation, specific anammox activity (SAA) of the preserved anammox biomass was determined by measuring (29)N2 production rate and transcription levels of hzsA gene encoding hydrazine synthase alpha subunit. Storage in nutrient medium containing 3 mM of molybdate at room temperature with periodical (every 45 days) supply of NH4(+) and NO2(-) was proved to be the most effective storage technique for "Ca. Brocadia sinica" biomass. Using this preservation condition, 96, 92 and 65% of the initial SAA was sustained after 45, 90 and 150 days of storage, respectively. Transcription levels of hzsA gene in biomass correlated with the SAA (R(2) = 0.83), indicating it can be used as a genetic marker to evaluate the anammox activity of preserved biomass. Furthermore, the 90-day-stored biomass was successfully reactivated by immobilizing in polyvinyl alcohol (6%, w/v) and sodium alginate (2%, w/v) gel and then inoculated to up-flow column reactors. Total nitrogen removal rates rapidly increased to 7 kg-N m(-3) d(-1) within 35 days of operation. Based on these results, the room temperature preservation with molybdate addition is simple, cost-effective and feasible at a practical scale, which will accelerate the practical use of anammox process for wastewater treatment.

  14. The potential role of As-sumo-1 in the embryonic diapause process and early embryo development of Artemia sinica.

    PubMed

    Chu, Bing; Yao, Feng; Cheng, Cheng; Wu, Yang; Mei, Yanli; Li, Xuejie; Liu, Yan; Wang, Peisheng; Hou, Lin; Zou, Xiangyang

    2014-01-01

    During embryonic development of Artemia sinica, environmental stresses induce the embryo diapause phenomenon, required to resist apoptosis and regulate cell cycle activity. The small ubiquitin-related modifier-1 (SUMO), a reversible post-translational protein modifier, plays an important role in embryo development. SUMO regulates multiple cellular processes, including development and other biological processes. The molecular mechanism of diapause, diapause termination and the role of As-sumo-1 in this processes and in early embryo development of Artemia sinica still remains unknown. In this study, the complete cDNA sequences of the sumo-1 homolog, sumo ligase homolog, caspase-1 homolog and cyclin B homolog from Artemia sinica were cloned. The mRNA expression patterns of As-sumo-1, sumo ligase, caspase-1, cyclin B and the location of As-sumo-1 were investigated. SUMO-1, p53, Mdm2, Caspase-1, Cyclin B and Cyclin E proteins were analyzed during different developmental stages of the embryo of A. sinica. Small interfering RNA (siRNA) was used to verify the function of sumo-1 in A. sinica. The full-length cDNA of As-sumo-1 was 476 bp, encoding a 92 amino acid protein. The As-caspases-1 cDNA was 966 bp, encoding a 245 amino-acid protein. The As-sumo ligase cDNA was 1556 bp encoding, a 343 amino acid protein, and the cyclin B cDNA was 739 bp, encoding a 133 amino acid protein. The expressions of As-sumo-1, As-caspase-1 and As-cyclin B were highest at the 10 h stage of embryonic development, and As-sumo ligase showed its highest expression at 0 h. The expression of As-SUMO-1 showed no tissue or organ specificity. Western blotting showed high expression of As-SUMO-1, p53, Mdm2, Caspase-1, Cyclin B and Cyclin E at the 10 h stage. The siRNA caused abnormal development of the embryo, with increased malformation and mortality. As-SUMO-1 is a crucial regulation and modification protein resumption of embryonic diapause and early embryo development of A. sinica.

  15. Proteomic analysis of acute responses to copper sulfate stress in larvae of the brine shrimp, Artemia sinica

    NASA Astrophysics Data System (ADS)

    Zhou, Qian; Wu, Changgong; Dong, Bo; Li, Fuhua; Liu, Fengqi; Xiang, Jianhai

    2010-03-01

    Proteomics was used to reveal the differential protein expression profiles of acute responses to copper sulfate exposure in larvae of Artemia sinica. Fourteen differentially displayed protein spots were detected and seven of them were identified. Three spots were up-expressed and identified: actin, heat shock protein 70, and chaperone subunit 1; three down-regulated proteins were identified: arginine kinase, elongation factor-2, and glycine-rich protein; and a newly expressed protein was identified as peroxiredoxin. The study indicates the involvement of all the differentially expressed proteins in the early responses of protein expression, and in the survival of A. sinica in the presence of copper and other heavy metals; the findings improve understanding of the organism’s adaptive responses and resistance.

  16. Review of the Journal Acta Informatica Medica During Eight Year Period: 2008-2015

    PubMed Central

    Masic, Izet; Begic, Edin; Zunic, Lejla

    2016-01-01

    Introduction: Acta Informatica Medica is official journal of the Academy for Medical Sciences of Bosnia and Herzegovina (from 2014 Acta Inform Med is published bimonthly). Aim: To evaluate journal “Acta Informatica Medica” in 2015 and compare findings to previous years. Material and methods: The study has retrospective and descriptive character, and included the period 2008-2015 (included 36 issues of journal). Results: A total of 83 (average 13,8 articles per journal) articles were published in Acta Informatica Medica during 2015. Analyzing the type of articles, original articles are present in majority during 2015 (68,6%) (by analyzing last eight years, 310 (67,3%) were original). During 2015, 27,7% of articles were related to the applied of Health informatics in field of clinical medicine, 63,8% preclinical medicine and 8,5% to public health. Collaboration rate in 2015 was 0,84. Most often the time required for decision on acceptance of article in 2015 is between 50 and 60 days. Articles came from 16 countries. According to scimagojr.com for 2014, Acta Informatica Medica has SCImago Journal Rank 0,166, while Cites / Doc. (2 years) parameter (widely used as impact index) is 0,70. According to GoogleScholar, h5 index is 11 and h5 median is 19. We analyzed the Acta Informatica Medica by “Publish or Perish” software - H index was 14, g index was 19 and e-index was 10.39. Conclusion: Year after year the highest number of original articles are published. Although the period of revision of articles is acceptable, the period up to two months is certainly not long, the goal is to reduce this period. Although the magazine in mentioned field found its place, although it is indexed in numerous bases, including: PubMed, PubMed Central, SCOPUS, EMBASE, EBSCO, etc. The main goal for next year is that the magazine becomes part of the Web of Science. Imperative is further internationalization of the magazine. PMID:27147796

  17. Identification, expression pattern and functional characterization of As-kip2 in diapause embryo restarting process of Artemia sinica.

    PubMed

    Zhang, Mengchen; Yao, Feng; Qin, Tong; Hou, Lin; Zou, Xiangyang

    2017-04-15

    Proper control of the cellular processes requires a variety of regulatory proteins that are involved in the cell cycle, proliferation and apoptosis. Cyclin-dependent kinase inhibitor (CKI) negatively regulates transcription and arrests the cell cycle in G1 phase. KIP2 is a member of CKI family, which could inhibit proliferation by tight-binding with several cyclin-CDK complexes. During the embryonic development of the brine shrimp, Artemia sinica, KIP2 plays a key role in the cell cycle regulation, but the specific mechanisms remain unknown. Herein, the 1023bp full-length cDNA of kip2 from A. sinica was cloned. The mRNA expression patterns of As-kip2, As-carp-1 in different development stages and pattern of As-kip2 under environmental stresses were investigated. In situ hybridization of As-kip2 mRNA and immunofluorescence of As-CARP-1 protein showed no tissue or organ specificity. Furthermore, western blotting showed the expressions levels of As-KIP2, As-E2F1, As-p53, As-cyclin E, As-SODD protein, and pattern of As-KIP2 under environmental stresses. Our research revealed that As-KIP2 plays crucial role in the restarting process of diapause embryo in Artemia sinica.

  18. APC/CCDC20 and APC/C play pivotal roles in the process of embryonic development in Artemia sinica

    PubMed Central

    Zhang, Mengchen; Yao, Feng; Luan, Hong; Zhao, Wei; Jing, Ting; Zhang, Shuang; Hou, Lin; Zou, Xiangyang

    2016-01-01

    Anaphase Promoting Complex or Cyclosome (APC/C) is a representative E3 ubiquitin ligase, triggering the transition of metaphase to anaphase by regulating degradation and ensures the exit from mitosis. Cell division cycle 20 (CDC20) and Cell division cycle 20 related protein 1 (CDH1), as co-activators of APC/C, play significant roles in the spindle assembly checkpoint, guiding ubiquitin-mediated degradation, together with CDC23. During the embryonic development of the brine shrimp, Artemia sinica, CDC20, CDH1 and CDC23 participate in cell cycle regulation, but the specific mechanisms of their activities remain unknown. Herein, the full-length cDNAs of cdc20 and cdc23 from A. sinica were cloned. Real-time PCR analyzed the expression levels of As-cdc20 and As-cdc23. The locations of CDH1, CDC20 and CDC23 showed no tissue or organ specificity. Furthermore, western blotting showed that the levels of As-CDC20, securin, cyclin B, CDK1, CDH1, CDC14B, CDC23 and geminin proteins conformed to their complicated degradation relationships during different embryo stages. Our research revealed that As-CDC20, As-CDH1 and APC mediate the mitotic progression, downstream proteins degradation and cellular differentiation in the process of embryonic development in A. sinica. PMID:27991546

  19. Citation analysis of Acta Dermatovenerologica Alpina, Pannonica et Adriatica: 1992-2011.

    PubMed

    Ostrbenk, Anja; Skamperle, Mateja; Poljak, Mario

    2012-09-01

    Acta Dermatovenerologica Alpina, Pannonica et Adriatica is small regional professional journal that started publishing in 1992. Despite the journal's relatively narrow readership, it has significantly improved its quality and global profile during the last 20 years, as shown in this citation analysis update. Since 1992, 654 bibliographical items have been published. Among these, 545 (83.4%) were considered WoS citable items and 109 (16.6%) WoS noncitable items. Since 2008, 90% of all published items have been considered WoS citable items and received an average of 1.9 citations per item. The predicted Acta Dermatovenerol APA impact factor calculated using data from a Cited Reference search of Thomson Scientific's Web of Science has shown steep and continuous increase since 2006, when the journal acquired full indexing status in Index Medicus/Medline, and has been above 0.5 since 2008.

  20. Novel MYH11 and ACTA2 mutations reveal a role for enhanced TGFβ signaling in FTAAD

    PubMed Central

    Renard, Marjolijn; Callewaert, Bert; Baetens, Machteld; Campens, Laurence; MacDermot, Kay; Fryns, Jean-Pierre; Bonduelle, Maryse; Dietz, Hal; Gaspar, Isabel Mendes; Cavaco, Diogo; Stattin, Eva-Lena; Schrander-Stumpel, Constance; Coucke, Paul; Loeys, Bart; De Paepe, Anne; De Backer, Julie

    2011-01-01

    Background Thoracic aortic aneurysm / dissection (TAAD) is a common phenotype that may occur as an isolated manifestation or within the constellation of a defined syndrome. In contrast to syndromic TAAD, the elucidation of the genetic basis of isolated TAAD has only recently started. To date, defects have been found in genes encoding extracellular matrix proteins (fibrillin-1, FBN1; collagen type III alpha 1, COL3A1), proteins involved in transforming growth factor beta (TGFβ) signaling (TGFβ receptor 1 and 2, TGFBR1/2; and SMAD3) or proteins that build up the contractile apparatus of aortic smooth muscle cells (myosin heavy chain 11, MYH11; smooth muscle actin alpha 2, ACTA2; and MYLK). Methods and results In 110 non-syndromic TAAD patients that previously tested negative for FBN1 or TGFBR1/2 mutations, we identified 7 ACTA2 mutations in a cohort of 43 familial TAAD patients, including 2 premature truncating mutations. Sequencing of MYH11 revealed an in frame splice-site alteration in one out of two probands with TAA(D) associated with PDA but none in the series of 22 probands from the cohort of 110 patients with non-syndromic TAAD. Interestingly, immunohistochemical staining of aortic biopsies of a patient and a family member with MYH11 and patients with ACTA2 missense mutations showed upregulation of the TGFβ signaling pathway. Conclusions MYH11 mutations are rare and typically identified in patients with TAAD associated with PDA. ACTA2 mutations were identified in 16% of a cohort presenting familial TAAD. Different molecular defects in TAAD may account for a different pathogenic mechanism of enhanced TGFβ signaling. PMID:21937134

  1. [National and international impact factor of Actas Españolas de Psiquiatría].

    PubMed

    Aleixandre Benavent, R; Valderrama Zurián, J C; Castellano Gómez, M; Simó Meléndez, R; Navarro Molina, C

    2004-01-01

    The aim of this paper is to present the bibliometric indicators of Actas Españolas de Psiquiatría that were obtained from the study "Potential impact factor of the Spanish medical journals in 2001", financed by the Spanish Ministerio de Educación, Cultura y Deporte. The citations made in Actas Españolas de Psiquiatría and its national and international impact factor and immediacy index have been obtained by the use of a methodology similar to the one used by the Institute for Scientific Information. The national indicators only take into account the citations made in 87 Spanish journals considered as sources, while those from the foreign source journals of Science Citation Index have been added to the previously cited ones. Actas Españolas de Psiquiatría has obtained a national impact factor of 0.315 and an international impact factor of 0.395, which places it as a leader in the Spanish psychiatric journals.

  2. A pure polysaccharide from Ephedra sinica treating on arthritis and inhibiting cytokines expression.

    PubMed

    Wang, Qiuhong; Shu, Zunpeng; Xing, Na; Xu, Bingqing; Wang, Changfu; Sun, Guibo; Sun, Xiaobo; Kuang, Haixue

    2016-05-01

    In our previous study, we found that the acidic polysaccharides of Ephedra sinica had immunosuppressive effect to treat rheumatoid arthritis and the pure polysaccharide ESP-B4 was the main composition of the acidic polysaccharides. At present, the exact molecular mechanism of ESP-B4 on treating arthritis is unclear. We are thus evaluating the properties of ESP-B4 on LPS-induced THP-1 pro-monocytic cells and adjuvant-induced arthritis in Wistar rats via TLR4. In vitro, ESP-B4 decreased the production of cytokines induced by LPS. In addition, ESP-B4 reduced the LPS-stimulated nuclear translocation of p65 subunit of NF-κB. Pretreatment with ESP-B4 significantly down-regulated the phosphorylation of MAPKs induced by LPS. Furthermore, in vivo, after 12 days of disease induced by adjuvant, rats were treated with ESP-B4 for 16 days. ESP-B4 significantly improved all parameters of inflammation. ESP-B4 reduced the release of inflammatory factors and cytokines by inhibiting the TLR4 signaling pathway to treat rheumatoid arthritis.

  3. Metabolites and the pharmacokinetics of kobophenol A from Caragana sinica in rats.

    PubMed

    Liang, Gao Lin; Bi, Jing Bo; Huang, Hong Qing; Zhang, Su; Hu, Chang-Qi

    2005-10-03

    This research aims to study the metabolism and pharmacokinetics of phytoestrogen kobophenol A (1), the main active compound of Caragana sinica (Buc'hoz) Rehd. (Fabaceae), in rats. Metabolites of 1 in rats' feces were isolated and purified by multi-chromatograph techniques; three new metabolites of 1, named koboquinone A (M1), koboquinone B (M2) and koboquinone C (M3), were isolated, purified from rats' feces after they being orally administered with 1. Structure identification of the metabolites was fulfilled by spectroscopic analysis. M1 and M2 are structurally different to those natural occurring stilbene tetramers, which also have para-quinone structure. M1 also showed the activity of stimulating the proliferation of cultured osteoblasts. The pharmacokinetics of 1 in rats could be described by a two-compartmental model (P<0.05). The half-life was 0.68 h for i.v. administration and 5.78 h for oral administration. The oral bioavailability of 1 was calculated to be 2.0%; rats tissue distribution experiments show that 1 was prominently concentrated in livers. Both of the low oral bioavailability and the rapid reduction of 1 in blood indicated a suitable formulation is needed while it is developed as a new drug.

  4. Stilbene derivatives as human 5-HT(6) receptor antagonists from the root of Caragana sinica.

    PubMed

    Kim, Dong Hyuk; Kim, Soon-Hee; Kim, Hyoung Ja; Jin, Changbae; Chung, Kwang Chul; Rhim, Hyewhon

    2010-01-01

    The 5-HT₆ receptor (5-HT₆R) is a member of the class of recently discovered 5-hydroxytryptamine (5-HT) receptors. Due to the lack of selective 5-HT₆R ligands, the cellular signaling mechanisms of the 5-HT₆R are poorly understood. We previously developed a cell-based high-throughput screening (HTS) method for the 5-HT₆R and screened synthetic chemical compounds. In the present study, we expanded our screening into natural products to find novel 5-HT₆R ligands. We found that the ethyl acetate fraction from the root of Caragana sinica (537-18BE) produced the most potent antagonistic activity. After further isolation of 537-18BE, we found that three stilbene derivatives, (+)-α-viniferin, miyabenol C and pallidol, are active constituents of 537-18BE inhibiting the 5-HT₆R. Among them, (+)-α-viniferin showed the most potent inhibition, and miyabenol C also produced a considerable inhibition. When examined effects on other neurotransmitters for selectivity, 537-18BE and three stilbene derivatives did not produce any notable effects on 5-HT₄, 5-HT₇, or muscarinic acetylcholine M1 (M(1)) receptors. Furthermore, 5-HT₆R antagonistic effects of (+)-α-viniferin, miyabenol C and pallidol were confirmed on extracellular signal-regulated kinase 1 and 2 (ERK1/2) which exerts effects in downstream pathways of 5-HT₆R activation.

  5. Structural characterization of lignins isolated from Caragana sinica using FT-IR and NMR spectroscopy.

    PubMed

    Xiao, Ling-Ping; Shi, Zheng-Jun; Xu, Feng; Sun, Run-Cang; Mohanty, Amar K

    2011-09-01

    In order to efficiently explore and use woody biomass, six lignin fractions were isolated from dewaxed Caragana sinica via successive extraction with organic solvents and alkaline solutions. The lignin structures were characterized by Fourier transform infrared spectroscopy (FT-IR) and 1D and 2D Nuclear Magnetic Resonance (NMR). FT-IR spectra revealed that the "core" of the lignin structure did not significantly change during the treatment under the conditions given. The results of 1H and 13C NMR demonstrated that the lignin fraction L2, isolated with 70% ethanol containing 1% NaOH, was mainly composed of beta-O-4 ether bonds together with G and S units and trace p-hydroxyphenyl unit. Based on the 2D HSQC NMR spectrum, the ethanol organosolv lignin fraction L1, extracted with 70% ethanol, presents a predominance of beta-O-4' aryl ether linkages (61% of total side chains), and a low abundance of condensed carbon-carbon linked structures (such as beta-beta', beta-1', and beta-5') and a lower S/G ratio. Furthermore, a small percentage (ca. 9%) of the linkage side chain was found to be acylated at the gamma-carbon.

  6. Stabilization of Ephedrine Alkaloid Content in Ephedra sinica by Selective Breeding and Stolon Propagation.

    PubMed

    Hiyama, Hajime; Ozawa, Aya; Kumazawa, Hiroaki; Takeda, Osami

    2017-01-01

    The Ephedra herb, which has been used in Kampo medicines, originates from terrestrial stems of Ephedra species. It is important to establish cultivation methods and cultivars to secure a stable supply of the Ephedra herb that would meet the quality standards for the ephedrine alkaloids content. In this study, we first grew Ephedra sinica plants derived from seeds in the field for 5 years. Then, for selective breeding of cultivars that could meet the quality standards for the ephedrine alkaloids content, we measured the content of total alkaloids (TAs), ephedrine (Eph), and pseudoephedrine (PEph) in individual plants derived from seedlings and grown for 4 years in the field. The range of the TA content in each individual plant was narrower than that among individual plants grown in the field. Therefore, individual plants were selected according to their TA content, Eph/PEph ratio, and stolon-formation capability. The selected individuals were propagated using stolons, and their TA content was studied for 2 years. In the second year, the TA content in terrestrial stems derived from stolons of the selected individuals was as high as that of their parents. Therefore, it was confirmed that the selected individuals that were propagated using stolons could produce TA reproducibly. This study suggested that selective breeding using stolon propagation is effective for stabilizing Ephedra herb TA content.

  7. Identification, expression pattern, cellular location and potential role of the caveolin-1 gene from Artemia sinica.

    PubMed

    Li, Xuejie; Yao, Feng; Zhang, Wei; Cheng, Cheng; Chu, Bing; Liu, Yan; Mei, Yanli; Wu, Yang; Zou, Xiangyang; Hou, Lin

    2014-05-01

    Caveolins are integral membrane proteins that serve as scaffolds to recruit numerous signaling molecules. Caveolins play an important role in membrane trafficking, signal transduction, substrate transport and endocytosis in differentiated cells. In this study, a caveolin-1 gene from Artemia sinica (As-cav-1) was successfully cloned for the first time. The full-length cDNA of As-cav-1 comprises 974 bp, with a 675 bp open reading frame (ORF) that encodes a polypeptide of 224 amino acids with a caveolin scaffolding domain (CSD) and two transmembrane domains. Multiple sequence alignment revealed that the putative As-CAV-1 protein sequence was relatively conserved across species, especially in the CSD domain. Real-time PCR revealed high levels of the As-cav-1 transcript at 0h of embryo development. Furthermore, As-cav-1 transcripts were highly upregulated under high salinity (200‰) and low temperature stresses (15°C). To further characterize As-cav-1, recombinant pET30a-cav-1 protein was expressed using a prokaryotic expression system. The recombinant protein comprised 290 amino acids with a theoretical molecular weight of 32kDa, and a predicted isoelectric point of 5.6. Western blotting of the expression levels of As-CAV-1 during different embryo development stages revealed that As-CAV-1 levels decreased gradually during development stages from 0 h to 40 h, and increased at 3d. Furthermore, western blotting showed that As-CAV-1 was upregulated to its highest expression level by low temperature stress (15°C) and high salinity. Confocal laser microscopy analysis, using antibodies generated against the recombinant As-CAV-1 protein, showed that As-CAV-1 was mostly located in the cell membrane. Our results suggested that As-cav-1 plays a vital role in protecting embryos from high salt damage and low temperature stress, especially during post-diapause embryonic development.

  8. Borrelia sinica sp. nov., a lyme disease-related Borrelia species isolated in China.

    PubMed

    Masuzawa, T; Takada, N; Kudeken, M; Fukui, T; Yano, Y; Ishiguro, F; Kawamura, Y; Imai, Y; Ezaki, T

    2001-09-01

    A survey was performed for Lyme disease borrelia in the southern part of China, in Zhejiang, Sichuan and Anhui provinces, along the Yangtze River valley, in May of 1997 and 1998. Twenty isolates from Ixodes granulatus, Ixodes ovatus, Apodemus agrarius and Niviventer confucianus were obtained. These isolates were characterized by RFLP of the 5S-23S rDNA intergenic spacer, sequence analysis of the intergenic spacer, 16S rDNA and flagellin gene, DNA-DNA hybridization analysis, SDS-PAGE and Western blotting with mAbs. Six isolates from A. agrarius, five from I. granulatus collected in Zhejiang province and one from N. confucianus in Sichuan province were highly similar to strains 10MT and 5MT isolated in Korea and classified as Borrelia valaisiana. Four isolates from A. agrarius and I. granulatus collected in Zhejiang province generated unique RFLP patterns and phylogenetic analysis of the 16S rDNA and flagellin gene sequences suggested that the isolates should be classified as B. valaisiana. Furthermore, three isolates (CMN1a, CNM2, CMN3T) from N. confucianus captured in Sichuan province and one (CWO1) from I. ovatus in Anhui province showed lower 165 rDNA sequence similarity (less than 99.0%) to sequences of previously described Lyme disease-related Borrelia species. DNA-DNA hybridization results revealed that strains CMN3T and CMN1a were clearly distinct from all other known Lyme disease Borrelia species. Electron microscope observation showed the spirochaetes to be morphologically similar to those of Borrelia, but the cells contained only four periplasmic flagella inserted at each end of the spirochaetes. Based on these results, a new Borrelia species, Borrelia sinica sp. nov., is proposed. Strain CMN3T is the type strain of this new species.

  9. Association of ActA to Peptidoglycan Revealed by Cell Wall Proteomics of Intracellular Listeria monocytogenes*

    PubMed Central

    García-del Portillo, Francisco; Calvo, Enrique; D'Orazio, Valentina; Pucciarelli, M. Graciela

    2011-01-01

    Listeria monocytogenes is a Gram-positive intracellular bacterial pathogen that colonizes the cytosol of eukaryotic cells. Recent transcriptomic studies have revealed that intracellular L. monocytogenes alter expression of genes encoding envelope components. However, no comparative global analysis of this cell wall remodeling process is yet known at the protein level. Here, we used high resolution mass spectrometry to define the cell wall proteome of L. monocytogenes growing inside epithelial cells. When compared with extracellular bacteria growing in a nutrient-rich medium, a major difference found in the proteome was the presence of the actin assembly-inducing protein ActA in peptidoglycan purified from intracellular bacteria. ActA was also identified in the peptidoglycan of extracellular bacteria growing in a chemically defined minimal medium. In this condition, ActA maintains its membrane anchoring domain and promotes efficient bacterial entry into nonphagocytic host cells. Unexpectedly, Internalin-A, which mediates entry of extracellular L. monocytogenes into eukaryotic cells, was identified at late infection times (6 h) as an abundant protein in the cell wall of intracellular bacteria. Other surface proteins covalently bound to the peptidoglycan, as Lmo0514 and Lmo2085, were detected exclusively in intracellular and extracellular bacteria, respectively. Altogether, these data provide the first insights into the changes occurring at the protein level in the L. monocytogenes cell wall as the pathogen transits from the extracellular environment to an intracytosolic lifestyle inside eukaryotic cells. Some of these changes include alterations in the relative amount and the mode of association of certain surface proteins. PMID:21846725

  10. Simultaneous determination of the contents of three stilbene oligomers in Caragana sinica collected in different seasons using an improved HPLC method.

    PubMed

    Shu, Na; Zhou, Hong; Hu, Changqi

    2006-04-01

    The objectives of this research were to determine simultaneously the contents of two stilbene tetramers, carasinol B (1) and kobophenol A (2), and one stilbene trimer, (+)-alpha-viniferin (3), in the roots, tubers, and leaves of Caragana sinica in various seasons. A HPLC method has been developed for efficiently quantifying the three analytes in the plant. Using this method, different samples of Caragana sinica were evaluated. The results showed that the contents of 1, 2, and 3 in the roots were much higher than those in the tubers, and the contents of stilbene tetramers were maximal in winter while the contents of the stilbene trimer were maximal in summer. Compounds 1, 2, and 3 could not be detected in the flowers of Caragana sinica in our detection ranges.

  11. Twins with progressive thoracic aortic aneurysm, recurrent dissection and ACTA2 mutation.

    PubMed

    Ware, Stephanie M; Shikany, Amy; Landis, Benjamin J; James, Jeanne F; Hinton, Robert B

    2014-10-01

    Thoracic aortic aneurysm (TAA) is a genetically mediated disease with variable age of onset. In the pediatric age range, nonsyndromic TAA frequently has a milder course than syndromic forms of TAA, such as Marfan syndrome or Loeys-Dietz syndrome. Herein, we describe 17-year-old identical twin brothers with severe progressive TAA due to a novel de novo ACTA2 mutation. Interestingly, both boys were diagnosed at age 11 with congenital mydriasis, a recently recognized manifestation of some ACTA2 mutations due to smooth muscle dysfunction. One of the brothers presented with acute-onset lower back pain that was identified as dissection of an abdominal aortic aneurysm. Imaging of the chest at this time showed severe fusiform TAA. Cardiac imaging in his twin showed similar TAA, but no abdominal aortic aneurysm. Both brothers underwent valve-sparing aortic root replacement, but have had progressive aortic disease with recurrent dissection requiring multiple surgeries. This case emphasizes the importance of identifying physical stigmata of smooth muscle dysfunction, such as mydriasis, as potential markers for associated aortopathy and vascular diseases.

  12. Detrimental effect of CO2-driven seawater acidification on a crustacean brine shrimp, Artemia sinica.

    PubMed

    Zheng, Chao-qun; Jeswin, Joseph; Shen, Kai-li; Lablche, Meghan; Wang, Ke-jian; Liu, Hai-peng

    2015-03-01

    The effects of the decline in ocean pH, termed as ocean acidification due to the elevated carbon dioxide in the atmosphere, on calcifying organisms such as marine crustacean are unclear. To understand the possible effects of ocean acidification on the physiological responses of a marine model crustacean brine shrimp, Artemia sinica, three groups of the cysts or animals were raised at different pH levels (8.2 as control; 7.8 and 7.6 as acidification stress according to the predictions for the end of this century and next century accordingly) for 24 h or two weeks, respectively, followed by examination of their hatching success, morphological appearance such as deformity and microstructure of animal body, growth (i.e. body length), survival rate, expression of selected genes (involved in development, immunity and cellular activity etc), and biological activity of several key enzymes (participated in antioxidant responses and physiological reactions etc). Our results clearly demonstrated that the cysts hatching rate, growth at late stage of acidification stress, and animal survival rate of brine shrimp were all reduced due to lower pH level (7.6 & 7.8) on comparison to the control group (pH 8.2), but no obvious change in deformity or microstructure of brine shrimp was present under these acidification stress by microscopy observation and section analysis. In addition, the animals subjected to a lower pH level of seawater underwent changes on their gene expressions, including Spätzle, MyD88, Notch, Gram-negative bacteria binding protein, prophenoloxidase, Apoptosis inhibitor 5, Trachealess, Caveolin-1 and Cyclin K. Meanwhile, several key enzyme activities, including superoxide dismutase, catalase, peroxidase, alkaline phosphatase and acid phosphatase, were also affected by acidified seawater stress. Taken together, our findings supports the idea that CO2-driven seawater acidification indeed has a detrimental effect, in case of hatching success, growth and survival, on

  13. [History of Actas Dermo-Sifiliográficas, part I: 1909-1959].

    PubMed

    Del Río, E

    2011-11-01

    Actas Dermo-Sifiliográficas was born in May 1909. At first, issues appeared in step with the academic year, but publication began to follow the calendar year in 1957. Volume 18 was skipped in 1926-7 in an effort to correct confusion in the numbering of volumes and pages of earlier issues. October 1928 saw the journal grow from 6 issues per year to 9. Although the Spanish Civil War brought publication to a halt during the 1936-7 academic year, Actas Dermo-Sifiliográficas was one of the first Spanish scientific journals to recover from the conflict. The initial print run of 100 copies was increased to 700 after the war. The content evolved over time: while originally conceived to provide a strict account of sessions of the Spanish Academy of Dermatology and Venereology (AEDV) -originally known as the Spanish Academy of Dermatology and Syphilology- the journal gradually came to include review articles, case reports, a section summarizing the content of international journals, news and various other types of writing. The editorial board and the association's board of directors were one and the same for many years. According to the earliest charter, the editor-in-chief was also the president of the association and the associate editor was the association's vice-president. The subjects of articles provide a faithful portrait of how the specialty has changed. Syphilis, a main concern before the introduction of penicillin in the 1940s, was sidelined afterwards. The appearance of 20th-century pharmaceuticals such as salvarsan, sulfa drugs, thiazides, and corticosteroids were soon reflected in the number of articles describing their use. Certain original contributions by Spanish authors to international dermatology first appeared in Actas Dermo-Sifiliográficas. Examples are Azúa's description of pseudoepithelioma and Covisa and Bejarano's of chancriform pyoderma. Volume 50 (1959), which included accounts of the 50th anniversary of the association and the journal, closed

  14. Association between ACTA1 candidate gene and performance, organs and carcass traits in broilers.

    PubMed

    Venturini, G C; Stafuzza, N B; Cardoso, D F; Baldi, F; Ledur, M C; Peixoto, J O; El Faro, L; Munari, D P

    2015-12-01

    This study investigates the genetic association of the SNP present in the ACTA1 gene with performance traits, organs and carcass of broilers to help marker-assisted selection of a paternal broiler line (TT) from EMBRAPA Swine and Poultry, Brazil. Genetic and phenotypic data of 1,400 broilers for 68 traits related to body performance, organ weights, weight of carcass parts, and yields as a percentage of organs and carcass parts were used. The maximum likelihood method, considering 4 analytical models, was used to analyze the genetic association between the SNP and these important economic traits. The association analysis was performed using a mixed animal model including the random effect of the animal (polygenic), and the fixed effects of sex (2 levels), hatch (5 levels) and SNP (3 levels), besides the random error. The traits significantly associated (P<0.05) with the SNP were analyzed, along with body weight at 42 days of age (BW42), by the restricted maximum likelihood method using the multi-trait animal model to estimate genetic parameters. The analysis included the residual and additive genetic random effects and the sex-hatch fixed effect. The additive effects of the SNP were associated with breast meat (BMY), liver yield (LIVY), body weight at 35 days of age (BW35); drumstick skin (DSW), drumstick (DW) and breast (BW) weights. The heritability estimates for these traits, in addition to BW42, ranged from 0.24±0.06 to 0.45±0.08 for LIVY and BW35, respectively. The genetic correlation ranged from 0.02±0.18 for LIVY and BMY to 0.97±0.01 for BW35 and BW42. Based on the results of this study, it can be concluded that ACTA1 gene is associated with performance traits BW35, LIV and BMY, DW, BW and DW adjusted for body weight at 42 days of age. Therefore, the ACTA1 gene is an important molecular marker that could be used together with others already described to increase the economically important traits in broilers.

  15. Cerebral arteriopathy associated with heterozygous Arg179Cys mutation in the ACTA2 gene: Report in 2 newborn siblings.

    PubMed

    de Grazia, Jose; Delgado, Ignacio; Sanchez-Montanez, Angel; Boronat, Susana; Del Campo, Miguel; Vazquez, Elida

    2017-01-01

    Mutations in the ACTA2 gene lead to a multisystemic smooth muscle dysfunction syndrome that causes vascular disease, congenital mydriasis, and variable presentation of urinary and gastrointestinal problems. The heterozygous Arg179 mutation is associated with a distinctive cerebrovascular phenotype. We report the cases of two newborn siblings with heterozygous ACTA2 Arg179Cys substitution and provide neuroimaging exams that demonstrate the distinctive cerebrovascular phenotype, also associated with variable degree of hypoplasia of the vertebro-basilar circulation as well as hypoxic-ischemic lesions.

  16. Nordisk ophthalmologisk tidsskrift 1889-1892: the Nordic Journal of Ophthalmology - a forerunner of Acta Ophthalmologica.

    PubMed

    Ehlers, Niels

    2012-06-01

    In the second half of the nineteenth century several ophthalmological journals appeared (Germany, England, France, United States). In the northern countries (Denmark, Finland, Norway, Sweden) an initiative lead to 'Nordisk ophthalmologisk Tidsskrift' published in the scandinavian languages in the years 1889-92. The 'driving force' behind the journal was the first professor in Ophthalmology in Copenhagen, Dr. Edmund Hansen Grut. The purpose with this presentation is to give the background for the rise and fall of the journal which was an attempt to promote Nordic Ophthalmology. The authors turned out, however, to be mainly those involved as editors. The journal never gained broad acceptance and it simply stopped in 1892, without any closing remarks. In spite of its short life the journal should be remembered for the very first publication on the arcuate scotoma, the Bjerrum scotoma from 1889. Although shortlived the initiative was not in vain, as can be read in the preface to the very first volume of Acta ophthalmologica.

  17. Citation analysis of Acta Dermatovenerologica Alpina, Pannonica et Adriatica: 1992-2013.

    PubMed

    Oštrbenk, Anja; Poljak, Mario

    2015-01-01

    Acta Dermatovenerologica Alpina, Pannonica et Adriatica is the leading journal in the field of dermatology and sexually transmitted infections in the region. Several important steps were taken during the last 20 years to improve the journal's quality, global visibility, and international impact. Since 1992, 699 bibliographical items have been published, which received 1,360 citations. Web of Science citable items received on average 2.29 citations per item. Importantly, almost half (49.6%) of all citations retrieved to date were received from 2012 onwards. The predicted impact factor was calculated in a way to match official impact factors published annually in Thomson Scientific Journal Citation Reports. Citation analysis shows a substantial increase of the predicted impact factor since 2006, with values above 0.5 since 2007. For the first time in the journal's history, a predicted impact factor value above 1.0 was recorded in 2013.

  18. Research on imaging, sensing, and characterization of cells at Research Center for Applied Sciences (RCAS), Academia Sinica

    NASA Astrophysics Data System (ADS)

    Tsai, Hui-Chen; Chang, Chun-Fang; Chen, Bi-Chang; Cheng, Ji-Yen; Chu, Chih-Wei; Han, Hsieh-Cheng; Hatanaka, Koji; Hsieh, Tung-Han; Lee, Chau-Hwang; Lin, Jung-Hsin; Tung, Yi-Chung; Wei, Pei-Kuen; Yang, Fu-Liang; Tsai, Din Ping

    2015-12-01

    Development of imaging, sensing, and characterization of cells at Research Center for Applied Sciences (RCAS) of Academia Sinica in Taiwan is progressing rapidly. The research on advanced lattice light sheet microscopy for temporal visualization of cells in three dimensions at sub-cellular resolution shows novel imaging results. Label-free observation on filopodial dynamics provides a convenient assay on cancer cell motility. The newly-developed software enables us to track the movement of two types of particles through different channels and reconstruct the co-localized tracks. Surface plasmon resonance (SPR) for detecting urinary microRNA for diagnosis of acute kidney injury demonstrates excellent sensitivity. A fully automated and integrated portable reader was constructed as a home-based surveillance system for post-operation hepatocellular carcinoma. New microfluidic cell culture devices for fast and accurate characterizations prove various diagnosis capabilities.

  19. Stereochemistry and conformation of skyllamycin, a non-ribosomally synthesized peptide from Streptomyces sp. Acta 2897.

    PubMed

    Schubert, Vivien; Di Meo, Florent; Saaidi, Pierre-Loïc; Bartoschek, Stefan; Fiedler, Hans-Peter; Trouillas, Patrick; Süssmuth, Roderich D

    2014-04-22

    Skyllamycin is a non-ribosomally synthesized cyclic depsipeptide from Streptomyces sp. Acta 2897 that inhibits PDGF-signaling. The peptide scaffold contains an N-terminal cinnamoyl moiety, a β-methylation of aspartic acid, three β-hydroxylated amino acids and one rarely occurring α-hydroxy glycine. With the exception of α-hydroxy glycine, the stereochemistry of the amino acids was assigned by comparison to synthetic reference amino acids applying chiral GC-MS and Marfey-HPLC analysis. The stereochemistry of α-hydroxy glycine, which is unstable under basic and acidic conditions, was determined by conformational analysis, employing a combination of data from NOESY-NMR spectroscopy, simulated annealing and free MD simulations. The simulation procedures were applied for both R- and S-configured α-hydroxy glycine of the skyllamycin structure and compared to the NOESY data. Both methods, simulated annealing and free MD simulations independently support S-configured α-hydroxy glycine thus enabling the assignment of all stereocenters in the structure of skyllamycin and devising the role of two-component flavin dependent monooxygenase (Sky39) as S-selective.

  20. Mutations in Smooth Muscle Alpha-Actin (ACTA2) Cause Coronary Artery Disease, Stroke, and Moyamoya Disease, Along with Thoracic Aortic Disease

    PubMed Central

    Guo, Dong-Chuan; Papke, Christina L.; Tran-Fadulu, Van; Regalado, Ellen S.; Avidan, Nili; Johnson, Ralph Jay; Kim, Dong H.; Pannu, Hariyadarshi; Willing, Marcia C.; Sparks, Elizabeth; Pyeritz, Reed E.; Singh, Michael N.; Dalman, Ronald L.; Grotta, James C.; Marian, Ali J.; Boerwinkle, Eric A.; Frazier, Lorraine Q.; LeMaire, Scott A.; Coselli, Joseph S.; Estrera, Anthony L.; Safi, Hazim J.; Veeraraghavan, Sudha; Muzny, Donna M.; Wheeler, David A.; Willerson, James T.; Yu, Robert K.; Shete, Sanjay S.; Scherer, Steven E.; Raman, C.S.; Buja, L. Maximilian; Milewicz, Dianna M.

    2009-01-01

    The vascular smooth muscle cell (SMC)-specific isoform of α-actin (ACTA2) is a major component of the contractile apparatus in SMCs located throughout the arterial system. Heterozygous ACTA2 mutations cause familial thoracic aortic aneurysms and dissections (TAAD), but only half of mutation carriers have aortic disease. Linkage analysis and association studies of individuals in 20 families with ACTA2 mutations indicate that mutation carriers can have a diversity of vascular diseases, including premature onset of coronary artery disease (CAD) and premature ischemic strokes (including Moyamoya disease [MMD]), as well as previously defined TAAD. Sequencing of DNA from patients with nonfamilial TAAD and from premature-onset CAD patients independently identified ACTA2 mutations in these patients and premature onset strokes in family members with ACTA2 mutations. Vascular pathology and analysis of explanted SMCs and myofibroblasts from patients harboring ACTA2 suggested that increased proliferation of SMCs contributed to occlusive diseases. These results indicate that heterozygous ACTA2 mutations predispose patients to a variety of diffuse and diverse vascular diseases, including TAAD, premature CAD, ischemic strokes, and MMD. These data demonstrate that diffuse vascular diseases resulting from either occluded or enlarged arteries can be caused by mutations in a single gene and have direct implications for clinical management and research on familial vascular diseases. PMID:19409525

  1. Cloning and expression of retinoblastoma-binding protein 4 gene in embryo diapause termination and in response to salinity stress from brine shrimp Artemia sinica.

    PubMed

    Wang, Xiaolu; Yao, Feng; Liang, Xiaoyu; Zhu, Xiaolin; Zheng, Ren; Jia, Baolin; Hou, Lin; Zou, Xiangyang

    2016-10-15

    Retinoblastoma binding protein 4 (RBBP4) is a nuclear protein with four WD-repeat sequences and thus belongs to a highly conserved subfamily of proteins with such domains. This retinoblastoma-binding protein plays an important role in nucleosome assembly and histone modification, which influences gene transcription and regulates cell cycle and proliferation. Artemia sinica (brine shrimp) undergoes an unusual diapause process under stress conditions of high salinity and low temperature. However, the role of RBBP4 in diapause termination of embryo development in A. sinica remains unknown. Here, the full-length cDNA of the As-rbbp4 gene was obtained from A. sinica and found to contain 1411 nucleotides, including a 1281 bp open reading frame (ORF), 63 bp 5'-untranslated region (UTR) and a 67-bp 3'-UTR, which encodes a 427 amino acid (48 kDa) protein. Bioinformatic analysis indicated As-RBBP4 to be mainly located in the nucleus, with a theoretical isoelectric point of 4.79. Protein sequence domain analysis showed that As-RBBP4 is a conserved protein, especially in the WD40 domain. No specificity in expression of this gene was observed in tissues or organs by in situ hybridization. Real-time quantitative PCR and Western blot analyses of As-RBBP4 gene and protein expression, respectively, showed notably high levels at 10 h and a subsequent downward trend. Obvious trends in upregulation of As-RBBP4 were observed under conditions of low temperature and high salinity stress. As-E2F1 and As-CyclinE also presented similar trends as that of As-RBBP4 in Western blots. Analysis of the RBBP4 expression in early embryonic development of A. sinica indicated that this protein plays an important role in diapause termination and cell cycle regulation.

  2. Identification, expression pattern and functional characterization of As-MyD88 in bacteria challenge and during different developmental stages of Artemia sinica.

    PubMed

    Qin, Tong; Zhao, Xinxin; Luan, Hong; Ba, Huazhong; Yang, Lei; Li, Zhenegmin; Hou, Lin; Zou, Xiangyang

    2015-05-01

    Myeloid differentiation factor 88 (MYD88), a key adapter protein in Toll-like receptor signaling, affects the immune response and the formation of the dorsal-ventral axis. Here, the 1555bp full-length cDNA of MyD88 from Artemia sinica (As-MyD88) was obtained. Molecular characterization revealed that the sequence includes an 1182bp open reading frame encoding a predicted protein of 393 amino acids. The predicted protein contains a death domain in the N-terminus, and box1 and 2 motifs of the TIR domain in the C-terminus. Real-time quantitative PCR, Western blotting and immunohistochemistry were used to determine the expression level, protein production and location of As-MYD88 during embryonic development and bacterial challenge. The highest expression level during embryonic development was at the 0h and 5h stages of A. sinica. As-MYD88 was remarkably upregulated after bacterial challenge. Our results suggested that As-MYD88 plays a vital role in response to bacterial challenge, and during post-diapause embryonic development of A. sinica.

  3. Differential protein expression using proteomics from a crustacean brine shrimp (Artemia sinica) under CO2-driven seawater acidification.

    PubMed

    Chang, Xue-Jiao; Zheng, Chao-Qun; Wang, Yu-Wei; Meng, Chuang; Xie, Xiao-Lu; Liu, Hai-Peng

    2016-11-01

    Gradually increasing atmospheric CO2 partial pressure (pCO2) has caused an imbalance in carbonate chemistry and resulted in decreased seawater pH in marine ecosystems, termed seawater acidification. Anthropogenic seawater acidification is postulated to affect the physiology of many marine calcifying organisms. To understand the possible effects of seawater acidification on the proteomic responses of a marine crustacean brine shrimp (Artemia sinica) three groups of cysts were hatched and further raised in seawater at different pH levels (8.2 as control and 7.8 and 7.6 as acidification stress levels according to the predicted levels at the end of this century and next century, respectively) for 1, 7 and 14 days followed by examination of the protein expression changes via two-dimensional gel electrophoresis. Searches of protein databases revealed that 67 differential protein spots were altered due to lower pH level (7.6 and 7.8) stress in comparison to control groups (pH 8.2) by mass spectrometry. Generally, these differentially expressed proteins included the following: 1) metabolic process-related proteins involved in glycolysis and glucogenesis, nucleotide/amino acid/fatty acid metabolism, protein biosynthesis, DNA replication and apoptosis; 2) stress response-related proteins, such as peroxiredoxin, thioredoxin peroxidase, 70-kDa heat shock protein, Na/K ATPase, and ubiquinol-cytochrome c reductase; 3) immune defence-related proteins, such as prophenoloxidase and ferritin; 4) cytoskeletal-related proteins, such as myosin light chain, TCP1 subunit 2, tropomyosin and tubulin alpha chain; and 5) signal transduction-related proteins, such as phospholipase C-like protein, 14-3-3 zeta, translationally controlled tumour protein and RNA binding motif protein. Taken together, these data support the idea that CO2-driven seawater acidification may affect protein expression in the crustacean A. sinica and possibly also in other species that feed on brine shrimp in the

  4. Arboreal adaptations of body fat in wild toque macaques (Macaca sinica) and the evolution of adiposity in primates.

    PubMed

    Dittus, Wolfgang P J

    2013-11-01

    There is a paucity of information on body composition and fat patterning in wild nonhuman primates. Dissected adipose tissue from wild toque macaques (Macaca sinica) (WTM), feeding on a natural diet, accounted for 2.1% of body weight. This was far less than fatness reported for nonhuman primates raised in captivity or for contemporary humans. In WTM, fatness increased with age and diet richness, but did not differ by sex. In WTM (none of which were obese) intra-abdominal fat filled first, and "excess" fat was stored peripherally in a ratio of about 6:1. Intermuscular fat was minimal (0.1%). The superficial paunch held <15% of subcutaneous fat weight in contrast to its much larger proportions in obese humans and captive monkeys where most added fat accumulates subcutaneously. With increasing total adiposity, accumulating fat shifted in its distribution among eight different main internal and peripheral deposit areas-consistent with maintaining body balance and a low center of gravity. The available data suggest that, in arboreal primates, adaptations for agile locomotion and terminal branch feeding set constraints on the quantity and distribution of fat. The absence of a higher percentage of body fat in females and neonates (as are typical of humans) suggests that arboreal adaptations preclude the development of fat-dependent, large-brained infants and the adipose-rich mothers needed to sustain them. The lifestyle and body composition of wild primates represent a more appropriate model for early human foragers than well-fed captive monkeys do.

  5. Vinculin Proteolysis Unmasks an ActA Homolog for Actin-based Shigella Motility

    PubMed Central

    Laine, Roney O.; Zeile, William; Kang, Fan; Purich, Daniel L.; Southwick, Frederick S.

    1997-01-01

    To generate the forces needed for motility, the plasma membranes of nonmuscle cells adopt an activated state that dynamically reorganizes the actin cytoskeleton. By usurping components from focal contacts and the actin cytoskeleton, the intracellular pathogens Shigella flexneri and Listeria monocytogenes use molecular mimicry to create their own actin-based motors. We raised an antibody (designated FS-1) against the FEFPPPPTDE sequence of Listeria ActA, and this antibody: (a) localized at the trailing end of motile intracellular Shigella, (b) inhibited intracellular locomotion upon microinjection of Shigella-infected cells, and (c) cross-reacted with the proteolytically derived 90-kD human vinculin head fragment that contains the Vinc-1 oligoproline sequence, PDFPPPPPDL. Antibody FS-1 reacted only weakly with full-length vinculin, suggesting that the Vinc-1 sequence in full-length vinculin may be masked by its tail region and that this sequence is unmasked by proteolysis. Immunofluoresence staining with a monoclonal antibody against the head region of vinculin (Vin 11-5) localized to the back of motile bacteria (an identical staining pattern observed with the anti-ActA FS-1 antibody), indicating that motile bacteria attract a form of vinculin containing an unmasked Vinc-1 oligoproline sequence. Microinjection of submicromolar concentrations of a synthetic Vinc-1 peptide arrested Shigella intracellular motility, underscoring the functional importance of this sequence. Western blots revealed that Shigella infection induces vinculin proteolysis in PtK2 cells and generates p90 head fragment over the same 1–3 h time frame when intracellular bacteria move within the host cell cytoplasm. We also discovered that microinjected p90, but not full-length vinculin, accelerates rates of pathogen motility by a factor of 3 ± 0.4 in Shigella-infected PtK2 cells. These experiments suggest that vinculin p90 is a rate-limiting component in actin-based Shigella motility, and that

  6. Transcriptome Profiling of Khat (Catha edulis) and Ephedra sinica Reveals Gene Candidates Potentially Involved in Amphetamine-Type Alkaloid Biosynthesis

    PubMed Central

    Groves, Ryan A.; Hagel, Jillian M.; Zhang, Ye; Kilpatrick, Korey; Levy, Asaf; Marsolais, Frédéric; Lewinsohn, Efraim; Sensen, Christoph W.; Facchini, Peter J.

    2015-01-01

    Amphetamine analogues are produced by plants in the genus Ephedra and by khat (Catha edulis), and include the widely used decongestants and appetite suppressants (1S,2S)-pseudoephedrine and (1R,2S)-ephedrine. The production of these metabolites, which derive from L-phenylalanine, involves a multi-step pathway partially mapped out at the biochemical level using knowledge of benzoic acid metabolism established in other plants, and direct evidence using khat and Ephedra species as model systems. Despite the commercial importance of amphetamine-type alkaloids, only a single step in their biosynthesis has been elucidated at the molecular level. We have employed Illumina next-generation sequencing technology, paired with Trinity and Velvet-Oases assembly platforms, to establish data-mining frameworks for Ephedra sinica and khat plants. Sequence libraries representing a combined 200,000 unigenes were subjected to an annotation pipeline involving direct searches against public databases. Annotations included the assignment of Gene Ontology (GO) terms used to allocate unigenes to functional categories. As part of our functional genomics program aimed at novel gene discovery, the databases were mined for enzyme candidates putatively involved in alkaloid biosynthesis. Queries used for mining included enzymes with established roles in benzoic acid metabolism, as well as enzymes catalyzing reactions similar to those predicted for amphetamine alkaloid metabolism. Gene candidates were evaluated based on phylogenetic relationships, FPKM-based expression data, and mechanistic considerations. Establishment of expansive sequence resources is a critical step toward pathway characterization, a goal with both academic and industrial implications. PMID:25806807

  7. Intentional introduction of Artemia sinica (Anostraca) in the high-altitude Tibetan lake Dangxiong Co: the new population and consequences for the environment and for humans

    NASA Astrophysics Data System (ADS)

    Jia, Qinxian; Anufriieva, Elena; Liu, Xifang; Kong, Fanjing; Shadrin, Nickolai

    2015-11-01

    The imbalance between supply and demand of Artemia cysts in China and around the world is increasing now. Salt lakes in Tibet may contribute to the solution of the problem. In Northern Tibet there are 26 saline lakes whose salinity and temperature may support Artemia survival at an altitude of 4 000-5 100 m. We found Artemia in 15 of these lakes. The saline lakes with Artemia populations mainly belong to the shallow basin lakes, and the majority of these lakes are small in area. The total area of lakes without Artemia is more than 1 000 km2. Lake Dangxiong Co (Co means lake in Tibet) was chosen for the intentional introduction of Artemia sinica. In 2004, 850 g of A. sinica cysts, originating from Qinghai, were introduced in the lake. Surveys in 2006-2014 showed that the average abundance of Artemia adults in the lake gradually increased from 20 ind./m3 in 2006 to 1950 ind./m3 in 2013. We assume that two subpopulations of A. sinica, separated by depth, may exist in the lake. The new Artemia population caused an increase in the number of species of phytoplankton and heterotrophic protozoa with a decrease of their total abundance. Water transparency also increased. Dominance in phytoplankton passed from cyanobacteria to diatoms. Changes occurred not only in the lake ecosystem; the number of water birds using the lakes also dramatically increased. Preliminary calculations showed that is it possible to harvest at least about 150 t cysts per year from the lake as well as 3.2 thousand tons of frozen or 350 t of dried biomass of adult Artemia.

  8. Book Review: Beitraege zur Astronomiegeschichte, Band 5 (Acta Historica Astronomiae Vol. 15)

    NASA Astrophysics Data System (ADS)

    Duerbeck, H. W.; Dick, W. R.; Hamel, J.

    2002-12-01

    The 15th volume of the Acta Historica Astronomiae is at the same time the fifth collection of essays on the history of astronomy (Beitraege zur Astronomiegeschichte, Band 5), edited by the historians of astronomy W.R. Dick (Potsdam) and J. Hamel (Berlin). Besides a few short notices and book reviews, the book contains 11 major articles, which deal with astronomical topics covering the time from the 16th to the 20th centuries. The first article, on the analysis and interpretation of historical horoscopes as a source of the history of science, is based on the inaugural lecture of its author, Guenther Oestmann. After a general introduction, which deals with the principles of horoscope making, the author discusses the horoscope of Count Heinrich Ranzau (1526-1598), the Danish governor of Schleswig-Holstein, who was a friend of Tycho Brahe. Oestmann shows that the astronomical-mathematical basis of such a horoscope can be reconstructed and interpreted. However, it is hardly possible to gain an insight in the process how the interpretation of a horoscope was done in detail. The second and third articles, by Franz Daxecker, deal with Athanasius Kircher and Christoph Scheiner, two catholic astronomers of the 17th century. Kircher's Organum Mathematicum is a calculating device that can be used in the fields of arithmetic, geometry, chronology, astronomy, astrology and others. The author provides extracts of the description of the Organum taken from a book by Caspar Schott, which deal with chronology and astronomy. A photograph of the Organum indicates that this tool consists of a set of tables glued on wooden or cardboard, but details of its contents and applications remain pretty obscure for the reader - a few elaborated examples would have been helpful. The second paper deals with the life of Christoph Scheiner SJ, the co-discoverer of sunspots (next to Galileo), after leaving Rome in 1633 - the year of the Galileo trial. Scheiner spent his later years in the Austrian and

  9. Molecular cloning, characterization and expression analysis of the protein arginine N-methyltransferase 1 gene (As-PRMT1) from Artemia sinica.

    PubMed

    Jiang, Xue; Yao, Feng; Li, Xuejie; Jia, Baolin; Zhong, Guangying; Zhang, Jianfeng; Zou, Xiangyang; Hou, Lin

    2015-07-01

    Protein arginine N-methyltransferase 1 (PRMT1) is an important epigenetic regulation factor in eukaryotic genomes. PRMT1 is involved in histone arginine loci methylation modification, changes in eukaryotic genomes' chromatin structure, and gene expression regulation. In the present paper, the full-length 1201-bp cDNA sequence of the PRMT1 homolog of Artemia sinica (As-PRMT1) was cloned for the first time. The putative As-PRMT1 protein comprises 346 amino acids with a SAM domain and a PRMT5 domain. Multiple sequence alignments revealed that the putative sequence of As-PRMT1 protein was relatively conserved across species, especially in the SAM domain. As-PRMT1 is widely expressed during embryo development of A. sinica. This is followed by a dramatic upregulation after diapause termination and then downregulation from the nauplius stage. Furthermore, As-PRMT1 transcripts are highly upregulated under conditions of high salinity and low temperature stress. These findings suggested that As-PRMT1 is a stress-related factor that might promote or inhibit the expression of certain genes, play a critical role in embryonic development and in resistance to low temperature and high salinity stress.

  10. Molecular characterization and expression of As-nurp1 gene from Artemia sinica during development and in response to salinity and temperature stress.

    PubMed

    Li, Qiuying; Zhang, Qiaozhi; Han, Lulu; Yuan, Zhe; Tan, Jian; Du, Bin; Zou, Xiangyang; Hou, Lin

    2012-06-01

    Nuclear protein 1 (NURP1) is a stress-related protein and closely related to diapause in the development of Artemia. In the present paper, the full-length 568-bp cDNA sequence of the nurp1 homolog of Artemia sinica (As-nurp1) was isolated by RACE technology for the first time. The putative As-nurp1 protein consists of 66 amino acids with a basic helix-loop-helix (bHLH) motif and a bipartite nuclear localization signal (NLS). Multiple sequence alignments revealed that the putative As-nurp1 protein sequence was relatively conserved across species, especially in the bHLH domain. The expression of As-nurp1 is widely distributed during A. sinica development. This is followed by a dramatic downregulation after diapause and is newly upregulated from the larval nauplius stage. Furthermore, As-nurp1 transcripts are highly upregulated under conditions of high salinity and low temperature. These findings suggest that As-nurp1 is stress-related and may act as a protective factor in embryonic development.

  11. Fetal akinesia caused by a novel actin filament aggregate myopathy skeletal muscle actin gene (ACTA1) mutation.

    PubMed

    Stenzel, Werner; Prokop, Stefan; Kress, Wolfram; Huppmann, Stephanie; Loui, Andrea; Sarioglu, Nanette M E; Laing, Nigel G; Sparrow, John C; Heppner, Frank L; Goebel, Hans H

    2010-08-01

    We report a female newborn, diagnosed with fetal akinesia in utero, who died one hour after birth. Post-mortem muscle biopsy demonstrated actin-filament myopathy based on immunolabelling for sarcomeric actin, and large areas of filaments, without rod formation, ultrastructurally. Analysis of DNA extracted from the muscle disclosed a novel de novo heterozygous c.44G>A, GGC>GAC, 'p.Gly15Asp' mutation in the ACTA1 gene. Analysis of the location of the mutated amino-acid in the actin molecule suggests the mutation most likely causes abnormal nucleotide binding, and consequent pathological actin polymerization. This case emphasizes the association of fetal akinesia with actin-filament myopathy.

  12. Twenty Years of Society of Medical Informatics of B&H and the Journal Acta Informatica Medica

    PubMed Central

    Masic, Izet

    2012-01-01

    In 2012, Health/Medical informatics profession celebrates five jubilees in Bosnia and Herzegovina: a) Thirty five years from the introduction of the first automatic manipulation of data; b) Twenty five years from establishing Society for Medical Informatics BiH; c) Twenty years from establishing scientific and professional journal of the Society for Medical Informatics of Bosnia and Herzegovina „Acta Informatica Medica“; d) Twenty years from establishing first Cathdra for Medical Informatics on biomedical faculties in Bosnia and Herzegovina and e) Ten years from the introduction of “Distance learning” in medical curriculum. All of the five mentioned activities in the area of Medical informatics had special importance and gave appropriate contribution in the development of Health/Medical informatics in Bosnia And Herzegovina. PMID:23322947

  13. Twenty years of society of medical informatics of b&h and the journal acta informatica medica.

    PubMed

    Masic, Izet

    2012-03-01

    In 2012, Health/Medical informatics profession celebrates five jubilees in Bosnia and Herzegovina: a) Thirty five years from the introduction of the first automatic manipulation of data; b) Twenty five years from establishing Society for Medical Informatics BiH; c) Twenty years from establishing scientific and professional journal of the Society for Medical Informatics of Bosnia and Herzegovina "Acta Informatica Medica"; d) Twenty years from establishing first Cathdra for Medical Informatics on biomedical faculties in Bosnia and Herzegovina and e) Ten years from the introduction of "Distance learning" in medical curriculum. All of the five mentioned activities in the area of Medical informatics had special importance and gave appropriate contribution in the development of Health/Medical informatics in Bosnia And Herzegovina.

  14. Molecular analysis and its expression of a pou homeobox protein gene during development and in response to salinity stress from brine shrimp, Artemia sinica.

    PubMed

    Wang, Jia-Qing; Hou, Lin; Yi, Nan; Zhang, Riu-Feng; Zou, Xiang-Yang

    2012-01-01

    Brine shrimps of the genus Artemia are aquatic species of economic importance because of their important significance to aquaculture and are used as a model species in physiology and developmental biology. Research on Artemia POU homeobox gene function will enhance our understanding of the physiological and developmental processes of POU homeobox gene in animals. Herein, a full-length cDNA encoding an Artemia POU homeobox protein gene 1 (APH-1) from Artemia sinica (designated as As-APH-1) was cloned and characterized by a reverse-transcription polymerase chain reaction (RT-PCR) and rapid amplification of cDNA end (RACE) method. The As-APH-1 gene encoded a protein of 388 amino acid polypeptide with a calculated molecular mass of 42.85kDa and an isoelectric point of 6.90 and the protein belongs to the POU III family. Multiple sequence alignments revealed that A. sinica As-APH-1 protein sequence shared a conserved POU homeobox domain with other species. The early and persistent expression of As-APH-1 in the naupliar stages by semi-quantitative RT-PCR and whole-mount embryonic immunohistochemistry suggest that As-APH-1 functions very early in the salt gland and may be required continuously in this organ. Later in development, expression of As-APH-1 begins to dramatically decrease and disappear in salt gland of the sub-adult Artemia. In addition, we also discovered that As-APH-1 increased obviously as the salinity increased, indicating that As-APH-1 might be used as a good indicator of salinity stress. In summary, we are the first to identify the As-APH-1 gene and to determine its gene expression patterns in early embryogenesis stages and in different salinity stress in brine shrimp, A. sinica. The result of expression of As-APH-1 affected by salinity changes will provide us further understanding of the underlying mechanisms of osmoregulation in Artemia early embryonic development.

  15. Coverage of Acta Dermatovenerologica Alpina, Pannonica et Adriatica in Elsevier's CiteScore index: a new tool for measuring the citation impact of academic journals.

    PubMed

    Poljak, Mario

    2017-03-01

    In December 2016, Elsevier launched a new tool that helps measure the citation impact of academic journals, called the CiteScore index. The CiteScore index values for 2015 confirmed the status of Acta Dermatovenerologica Alpina, Pannonica et Adriatica (Acta Dermatovenerol APA) as the leading journal in dermatology and sexually transmitted infections in the region. Sixty-five articles published in Acta Dermatovenerol APA from 2012 to 2014 received a total of 77 citations in 2015, resulting in a CiteScore index value of 1.18 for the journal. More than half of the articles published from 2012 to 2014 received at least one citation in 2015. Acta Dermatovenerol APA performed well in all three categories listed because it is ranked 384th out of 1,549 journals in the category General Medicine (75th percentile), 53rd out of 122 journals in the category Dermatology (56th percentile), and 142nd out of 246 journals in the category Infectious Diseases (42nd percentile).

  16. Streptomyces rochei ACTA1551, an Indigenous Greek Isolate Studied as a Potential Biocontrol Agent against Fusarium oxysporum f.sp. lycopersici

    PubMed Central

    Kanini, Grammatiki S.; Katsifas, Efstathios A.; Savvides, Alexandros L.; Karagouni, Amalia D.

    2013-01-01

    Many studies have shown that several Greek ecosystems inhabit very interesting bacteria with biotechnological properties. Therefore Streptomyces isolates from diverse Greek habitats were selected for their antifungal activity against the common phytopathogenic fungus Fusarium oxysporum. The isolate encoded ACTA1551, member of Streptomyces genus, could strongly suppress the fungal growth when examined in antagonistic bioassays in vitro. The isolate was found phylogenetically relative to Streptomyces rochei after analyzing its 16S rDNA sequence. The influence of different environmental conditions, such as medium composition, temperature, and pH on the expression of the antifungal activity was thoroughly examined. Streptomyces rochei ACTA1551 was able to protect tomato seeds from F. oxysporum infection in vivo while it was shown to promote the growth of tomato plants when the pathogen was absent. In an initial effort towards the elucidation of the biochemical and physiological nature of ACTA1551 antifungal activity, extracts from solid streptomycete cultures under antagonistic or/and not antagonistic conditions were concentrated and fractionated. The metabolites involved in the antagonistic action of the isolate showed to be more than one and produced independently of the presence of the pathogen. The above observations could support the application of Streptomyces rochei ACTA1551 as biocontrol agent against F. oxysporum. PMID:23762841

  17. Rimitas Zoologicas - para Colorear ("doodle art"). (Aminal Rhymes - for Coloring.)

    ERIC Educational Resources Information Center

    Marquez, Jerry

    The animal rhymes are written in Spanish and dittoed on white card stock, ready for coloring and use. The rhyme, together with a basic vocabulary and pronunciation difficulties for English-speakers, is printed on the back of each picture so that the cards may be shown and read at the same time. Rhymes are about a butterfly, frog, cow, fish, cat,…

  18. The beginnings of Acta Neurochirurgica and the work of Fritz Loew, chief editor from 1958 - 1997. An historical vignette.

    PubMed

    Reulen, Hans-Jürgen; Collmann, Hartmut

    2012-07-01

    Acta Neurochirurgica was founded in 1950, in the difficult time after World War II, by Mario Milletti (Bologna) and Wolfram Sorgo (Innsbruck), and published by Springer press, Vienna. From the beginning the new journal was conceived as an international journal with an impressive list of outstanding neurosurgeons in the editorial board. Only a few years later the issues appeared at irregular intervals due to individual problems of both editors. Wilhelm Tönnis took the initiative to keep the journal alive, when he asked-in consent with Springer press-his staff member Fritz Loew to continue the editorial work and to assemble a new prestigious editorial board. Loew succeeded with both tasks and remained editor-in-chief for nearly 38 years. Initially, all papers were published in the native languages of the authors: English, French, German, Italian and Spanish. With ongoing time the journal accepted manuscripts in English only. The slow progress of this process exemplifies the slow integration of the European countries. In 1971, at the founding meeting of the European Association of Neurosurgical Societies (EANS) in Prague, Acta Neurochirurgica became the official organ of the EANS. Right from the beginning of Acta Neurochirurgica, Supplement volumes were added. Also, the book series Advances and Technical Standards in Neurosurgery is an offspring of Acta Neurochirurgica. Acta Neurochirurgica has become one of the most important neurosurgical journals worldwide. This historical sketch is based on an interview with Fritz Loew, now 91 years old, to which data from the available literature and the Archives of German Neurosurgery, as well as personal information by several colleagues were added.

  19. Genetic subtyping of Listeria monocytogenes via multiple-locus sequence typing using iap, sigB and actA

    PubMed Central

    YOSHIKAWA, Yuko; OCHIAI, Yoshitsugu; MOCHIZUKI, Mariko; FUJITA, Osamu; TAKANO, Takashi; HONDO, Ryo; UEDA, Fukiko

    2016-01-01

    Pulse field gel electrophoresis (PFGE) is widely used for listeriosis surveillance. Although this technique is effective for epidemiology, the data among laboratories are inconsistent. We previously reported a method for Listeria monocytogenes subtyping combined with sequence analysis of partial iap and whole genome restriction fragment length polymorphism (RFLP) using XbaI, ClaI (BanIII) and PstI. However, distinguishing subtypes was challenging, because the output comprised complicated fragment patterns. In this study, we aimed to establish a simple genotyping method that does not depend on visual observation, rather it focuses on multi-locus sequence typing (MLST) using three genes, iap, sigB and actA. Sixty-eight strains of L. monocytogenes including EGD-e as a reference strain were investigated to ensure consistency with previous data on the genetic characterization. All strains were grouped into 29 types by both analyses. Although there are some differences in classification, major clades included the same strains. Simpson’s indices of diversity (SID) by MLST and iap-RFLP-based typing were 0.967 (95% confidence interval [CI]: 0.955/0.978) and 0.967 (95% CI: 0.955/0.979), respectively. The discriminatory power of both methods can be considered almost identical. Compared with the results of 38 selected strains, the strains within the MLST clusters in this study coincided with those obtained using PFGE. Thus, the MLST strategy could help differentiate among L. monocytogenes isolates during epidemiological studies. PMID:27725353

  20. Comment on “Chen et al., Fabrication and photovoltaic conversion enhancement…”, Electrochimica Acta, 2014

    NASA Astrophysics Data System (ADS)

    Valentic, Lara; Gorji, Nima E.

    2015-09-01

    In a recent article, Chen et al. [Electrochimica Acta, 2014, 130: 279] presented their fabrication and characterization results on a graphene/n-Si solar cell where the Au nanoparticles were inserted in graphene to increase its optical and electrical properties. The higher efficiency of the device was attributed to increased conductivity of graphene after doping with Au nanoparticles. However, the knowledge in the field of Schottky diode solar cells relates this to increased band bending at the junction. Also, to explain the instability behaviour, they concluded that the growth of silicon oxide on the Si surface or oxygen adsorption on the window layer resulted in the device performance increasing initially and decreasing in the end. However, this instability seems to be due to variation in series resistance reduced at the beginning because of slightly lowered Fermi level and increased at the end by the self-compensation by deep in-diffusion of Au nanoparticles into n-Si layer. We also propose that inserting a very thin p-type layer at the junction will enhance the carrier collection and performance of this device.

  1. Vascular disease-causing mutation R258C in ACTA2 disrupts actin dynamics and interaction with myosin

    PubMed Central

    Lu, Hailong; Fagnant, Patricia M.; Bookwalter, Carol S.; Joel, Peteranne; Trybus, Kathleen M.

    2015-01-01

    Point mutations in vascular smooth muscle α-actin (SM α-actin), encoded by the gene ACTA2, are the most prevalent cause of familial thoracic aortic aneurysms and dissections (TAAD). Here, we provide the first molecular characterization, to our knowledge, of the effect of the R258C mutation in SM α-actin, expressed with the baculovirus system. Smooth muscles are unique in that force generation requires both interaction of stable actin filaments with myosin and polymerization of actin in the subcortical region. Both aspects of R258C function therefore need investigation. Total internal reflection fluorescence (TIRF) microscopy was used to quantify the growth of single actin filaments as a function of time. R258C filaments are less stable than WT and more susceptible to severing by cofilin. Smooth muscle tropomyosin offers little protection from cofilin cleavage, unlike its effect on WT actin. Unexpectedly, profilin binds tighter to the R258C monomer, which will increase the pool of globular actin (G-actin). In an in vitro motility assay, smooth muscle myosin moves R258C filaments more slowly than WT, and the slowing is exacerbated by smooth muscle tropomyosin. Under loaded conditions, small ensembles of myosin are unable to produce force on R258C actin-tropomyosin filaments, suggesting that tropomyosin occupies an inhibitory position on actin. Many of the observed defects cannot be explained by a direct interaction with the mutated residue, and thus the mutation allosterically affects multiple regions of the monomer. Our results align with the hypothesis that defective contractile function contributes to the pathogenesis of TAAD. PMID:26153420

  2. Acta Armamentarii (Selected Articles),

    DTIC Science & Technology

    1982-12-01

    method is not appropriate in engineering technology. In 1968, A.N. Krayko, V.K. Starkov and L.Ye. Sternin (2] used the supposition of the one-dimensional...Equation (23) is written as the general form ~- G GA_ * dx -~& AA 4 .) 2 1W G,, +2’, 4 XpACP rym In the Equation 10 2vv, p2K-! PVV.-i-UtV’n,, +V j K Yay...Lag Loss", Marble, F.E. AIAA J., Vol. 1, No. 12, 1963. 14 [2] A.N. Krayko, L.E. Sternin, V.K. Starkov , "bo±urion or one- dimensional approximation of a

  3. Acta Armamentarii (Selected Articles).

    DTIC Science & Technology

    1986-07-08

    the position of the change point can be determined. This is very helpful in understanding the reason for unsteady burning. Therefore, this is superior...properties of CIDP propellant have been published. Domestically, there were attempts to measure the dynamic mechanical properties of solid propellants with...these three propellants are rather large. Besides the different formulas and composite concentrations, the main reason is that they have different

  4. New record of Apoholosticha sinica (Ciliophora, Urostylida) from the UK: morphology, 18S rRNA gene phylogeny and notes on morphogenesis.

    PubMed

    Hu, Xiaozhong; Fan, Yangbo; Warren, Alan

    2015-08-01

    The benthic urostylid ciliate Apoholosticha sinicaFan et al., 2014 was isolated from a salt marsh at Blakeney, UK, and reinvestigated using light microscopy and small-subunit rRNA gene sequencing. Morphologically, it corresponds well with the original description. Several stages of divisional morphogenesis and physiological reorganization were also observed from which the following could be deduced: (i) the oral apparatus is completely newly built in the proter; (ii) frontal-ventral-transverse cirral anlage II does not produce a buccal cirrus; (iii) each of the posteriormost three or four anlagen contributes one transverse cirrus at its posterior end; (iv) a row of frontoterminal cirri originates from the rearmost frontal-ventral-transverse cirral anlage; (v) the last midventral row is formed from the penultimate frontal-ventral-transverse cirral anlage. Based on new data, two diagnostic features were added to the genus definition: (i) the midventral complex is composed of midventral pairs and midventral row and (ii) pretransverse ventral cirri are absent. Based on a combination of morphological and morphogenetic data, the genus Apoholosticha is assigned to the recently erected subfamily Nothoholostichinae Paiva et al., 2014, which is consistent with sequence comparison and phylogenetic analyses based on SSU rRNA gene data. It is also concluded that this benthic species, previously reported only from China, is not an endemic form.

  5. [The false positive reaction of the Triage panel drug-of-abuse by herbal drugs ma-huang (Ephedra sinica (Ephedraceae))].

    PubMed

    Nishiguchi, M; Kinoshita, H; Higasa, K; Taniguchi, T; Ouchi, H; Minami, T; Marukawa, S; Yoshinaga, K; Yamauchi, J; Aoki, S; Hishida, S

    2001-11-01

    We investigated false-positive reactions obtained from a drug screening test using a Triage panel. We detected 2 cases giving false-positive reaction for AMP (amphetamine, methamphetamine) during the screening of 187 normal subjects. Subsequent follow up testing by high-performance liquid chromatography (HPLC), showed both to be false-positive reactions. As both cases have a history of ingesting the herbal drug, Ma-huang (Ephedra sinica (Ephedraceae)), containing ephedrine, we examined the relationship between false-positive reactions on Triage and Ma-huang. All urine samples collected from 7 healthy volunteers following administration of Ma-huang indicated AMP positive on Triage. Also a high ratio of AMP positives was observed in the patients who were administered Ma-huang-containing drugs at the hospital. However, none of them were identified as true-positives by HPLC or gas chromatography mass spectrometry (GC/MS) analysis. The extract of Ma-huang contained in herbal drugs, which otherwise contain neither amphetamine nor its derivatives, gives (AMP) positive indications on Triage. We speculate that unidentified components of Ma-huang cause the false-positive reactions. We suggest that follow-up tests by GC/MS or HPLC are needed wherever a positive result is obtained from a screening test by Triage. Furthermore, it will be established to continue collecting information on prescribed and non-prescribed drugs.

  6. BOOK REVIEW: Astronomie von Olbers bis Schwarzschild. Nationale Entwicklungen und internationale Beziehungen im 19. Jahrhundert (Acta Historica Astronomiae Vol. 16)

    NASA Astrophysics Data System (ADS)

    Sterken, C.; Dick, W. R.; Hamel, J.

    2002-12-01

    The 14th volume of the Acta Historica Astronomiae is the Proceedings of a Colloquium International Relationships in Astronomy (in German) organised by the History of Astronomy Section of the Astronomische Gesellschaft held on September 18 in Lilienthal, Germany. The book contains 13 articles on astronomical topics covering the 19th and 20th centuries. The first paper is by Guenther Oestmann and deals with contemporary assessments of Johann Hieronymus Schroeter's (1745-1816) astronomical works and with later judgements of the scientific importance and significance of his observations as seen by astronomers and historians. This report is complemented by a second article on Schroeter's 25-ft reflector in Lilienthal near Bremen. To this end, author Felix Luehning has constructed a scale model of the telescope, and shows how the building of a model brings a deeper understanding of function and handling of this instrument. This brings us to a third paper on telescope building in Lilienthal: Hans-Joachim Leue describes the cooperation of Johann Hieronymus Schroeter and Johann Gottlieb Schrader in developing a white reflecting metal alloy for use as telescope mirror. The fourth article, by Klaus Schillinger, describes on the basis of archival documents the aquisition history of the Herschel telescopes, including telescope quality check, repair and building. Memorial sites referring to Wilhelm Olbers, Johann Hieronymus Schroeter, Friedrich Wilhelm Bessel and Carl Friedrich Gauss are described by Arno Langkavel in two walks outlined in the very last paper of this book. Peter Brosche, in the fifth paper, discusses the rediscovery of Ceres in December1801, a discovery that was the result of the combined efforts of a theoretician (Gauss) and an observer (Zach). Juergen Hamel's paper is based on previously unused archival sources and discusses the outstanding role played by H. C. Schumacher (1780-1850, editor of the Astronomische Nachrichten) in the communication between

  7. Anti-arthritic effects of Ephedra sinica STAPF herb-acupuncture: inhibition of lipopolysaccharide-induced inflammation and adjuvant-induced polyarthritis.

    PubMed

    Yeom, Mi-Jung; Lee, Han-Chang; Kim, Gun-Ho; Lee, Hye-Jung; Shim, Insop; Oh, Seung-Kyu; Kang, Sung-Keel; Hahm, Dae-Hyun

    2006-01-01

    Anti-inflammatory and anti-arthritic effects of water distillates of Ephedra sinica STAPF (ES), in herb-acupuncture, on the inflammatory responses of arthritis was investigated using phorbol 12-myristate 13-acetate (PMA)/lipopolysaccharide (LPS)-induced human macrophage and adjuvant-induced arthritic rat. The luciferase reporter vectors driven by the tumor necrosis factor (TNF)-alpha and cyclooxygenase-2 promoters were transiently transfected into U937 cells, which were then differentiated and stimulated by PMA and LPS, respectively, to develop an in vitro anti-inflammation assay system. The luciferase activities, observed in the activated U937 cells, were significantly inhibited by ES herb-acupuncture, compared to those of PD98509 and berberine. To evaluate ES herb-acupuncture as a novel anti-arthritic therapy, a polyarthritic rat model was developed using heat-killed Mycobacterium tuberculosis, and 50 mul of ES distillate was subcutaneously injected into the ST36 acupoint on each knee joint. While the articular indexes of arthritic rats were evidently decreased by ES herb-acupuncture, their body weights did not regain their initial levels. This may be due to the accelerating effects of ES on weight-loss and fat consumption. The mRNA expressions of TNF-alpha and interleukin (IL)-6 genes, which were closely stimulated in the arthritic rat joints, were found to be restored to the normal levels through the ES treatment. In the case of IL-1beta, the recovery was not significant but substantial. The anti-arthritic effect of ES herb-acupuncture was not found in the ES-treated/non-acupoint group. In conclusion, the ES herb-acupuncture into the ST36 acupoint was found to be effective in alleviating the inflammatory response and thus arthritic symptoms in adjuvant-induced arthritic rats.

  8. Validating skinfold thickness as a proxy to estimate total body fat in wild toque macaques (Macaca sinica) using the mass of dissected adipose tissue.

    PubMed

    Dittus, Wolfgang P J; Gunathilake, K A Sunil

    2015-06-01

    Skinfold thickness (SFT) has been used often in non-human primates and humans as a proxy to estimate fatness (% body fat). We intended to validate the relation between SFT (in recently deceased specimens) and the mass of adipose tissue as determined from dissection of fresh carcasses of wild toque macaques (Macaca sinica). In adult male and female toque macaques body composition is normally 2% adipose tissue. Calipers for measuring SFT were suitable for measuring only some subcutaneous deposits of adipose tissue but were not suitable for measuring large fat deposits within the body cavity or minor intermuscular ones. The anatomical distribution of 13 different adipose deposits, in different body regions (subcutaneous, intra-abdominal and intermuscular) and their proportional size differences, were consistent in this species (as in other primates), though varying in total mass among individuals. These consistent allometric relationships were fundamental for estimating fatness of different body regions based on SFT. The best fit statistically significant correlations and regressions with the known masses of dissectible adipose tissue were evident between the SFT means of the seven sites measured, as well as with a single point on the abdomen anterior to the umbilicus. SFT related to total fat mass and intra-abdominal fat mass in curvilinear regressions and to subcutaneous fat mass in a linear relationship. To adjust for differences in body size among individuals, and to circumvent intangible variations in total body mass allocated, for example to the gastro-intestinal contents, dissected fat mass was estimated per unit body size (length of crown-rump)(3). SFT had greater coefficients of correlation and regressions with this Fat Mass Index (g/dm(3)) than with Percent Body Fat.

  9. China Report, Science and Technology, No. 188

    DTIC Science & Technology

    1983-02-18

    PHYSICS DIWEN WULI [ACTA PHYSICA TEMPERATURAE HUMILIS SINICA], No 4, 1982 ...................................................... 13 THERMOPHYSIC S...Epoxy Resin" SOURCE: Beijing DIWEN WULI [ACTA PHYSICA TEMPERATURAE HUMILIS SINICA] in Chinese No 4, 1982 pp 284-290 TEXT OF ENGLISH ABSTRACT: A...34Investigations of Model JWL-150A Superconducting Magnet Power Supply and SCR Automatic Protection System" SOURCE: Beijing DIWEN WULI [ACTA PHYSICA TEMPERATURAE

  10. JPRS Report, Science & Technology. China: Stealth/Counter-Stealth Research.

    DTIC Science & Technology

    1992-11-19

    Frequency-Selective Surfaces 92FE0801F Beijing DIANZIXUEBAO [ACTA ELECTRONICA SINICA] in Chinese Vol 20 No 6, Jun 92 pp 85-88 [Article by Shen...microwave devices and electromag- netic scattering. Motion Compensation Method in ISAR Imaging 92FE0801A Beijing DIANZIXUEBAO [ACTA ELECTRONICA ...Chinese Society of Electronics and an editor of DIANZI XUEBAO [ACTA ELECTRONICA SINICA]. Deng Wenbiao Born in February 1961, he graduated from the

  11. A rebuttal to "A comment to 'Normalization of urinary pteridines by urine specific gravity for early cancer detection' [Clin. Chim. Acta 435 (2014) 42-47]".

    PubMed

    Ma, Yinfa; Burton, Casey; Shi, Honglan

    2015-01-01

    We really appreciate the comments from Drs. Reibnegger and Fuchs regarding our recent publication "Normalization of urinary pteridines by urine specific gravity for early cancer detection [Clin. Chim. Acta 435 (2014) 42-47]". In their letter, Drs. Reibnegger and Fuchs identify several potential concerns regarding our recent publication [1] that evaluated the normalization performance of urine specific gravity (USG) and urinary creatinine with respect to the diagnostic properties of selected pteridines in discerning aggressive and benign breast cancers. Their letter not only provides unique insights that are both relevant and helpful to many researchers engaging in similar studies, but also provides a wonderful opportunity for us to address these potential concerns that may also be shared by other readers. We addressed all of the comments by Drs. Reibnegger and Fuchs in this letter.

  12. In-Vitro, Anti-Bacterial Activities of Aqueous Extracts of Acacia catechu (L.F.)Willd, Castanea sativa, Ephedra sinica stapf and shilajita mumiyo Against Gram Positive and Gram Negative Bacteria

    PubMed Central

    Dashtdar, Mehrab; Dashtdar, Mohammad Reza; Dashtdar, Babak; shirazi, Mohammad khabaz; Khan, Saeed Ahmad

    2013-01-01

    Objective: Evaluations of the in-vitro anti-bacterial activities of aqueous extracts of Acacia catechu (L.F.)Willd, Castanea sativa, Ephedra sinica stapf and Shilajita mumiyo against gram-positive bacteria (Staphylococcus aureus, Streptococcus pneumonia) and gram-negative bacteria (Escherichia coli, klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa) are reasonable since these ethnomedicinal plants have been used in Persian folk medicine for treating skin diseases, venereal diseases, respiratory problems and nervous disorders for ages. Methods: The well diffusion method (KB testing) with a concentration of 250 μg/disc was used for evaluating the minimal inhibitory concentrations (MIC). Maximum synergistic effects of different combinations of components were also observed. Results: A particular combination of Acacia catechu (L.F.) Willd, Castanea sativa, Ephedra sinica stapf and shilajita mumiyo extracts possesses an outstanding anti-bacterial activity. It's inhibiting effect on microorganisms is significant when compared to the control group (P< 0.05). Staphylococcus aureus was the most sensitive microorganism. The highest antibacterial activity against gram-positive bacteria (Staphylococcus aureus, Streptococcus pneumonia) or gram-negative bacteria (Escherichia coli, Klebsiella pneumonia, Proteus mirabilis and Pseudomonas aeruginosa) was exerted by formula number 2 (Table1). Conclusion: The results reveal the presence of antibacterial activities of Acacia catechu, Castanea sativa husk, Ephedra sp. and Mumiyo against gram-positive and gram-negative bacteria. Synergistic effects in a combined formula, especially in formula number 2 (ASLANⓇ) can lead to potential sources of new antiseptic agents for treatment of acute or chronic skin ulcers. These results considering the significant antibacterial effect of the present formulation, support ethno-pharmacological uses against diarrheal and venereal diseases and demonstrate use of these plants to treat

  13. Pioneering Studies on Cephalopod's Eye and Vision at the Stazione Zoologica Anton Dohrn (1883-1977)

    PubMed Central

    Dröscher, Ariane

    2016-01-01

    From the late nineteenth century onwards, the phenomena of vision and the anatomy and physiology of the eye of marine animals induced many zoologists, ethologists, physiologists, anatomists, biochemists, and ophthalmologists to travel to the Zoological Station in Naples. Initially, their preferred research objects were fish, but it soon became evident that cephalopods have features which make them particularly suited to research. After the first studies, which outlined the anatomical structure of cephalopods' eyes and optic nerves, the research rapidly shifted to the electrophysiology and biochemistry of vision. In the twentieth century these results were integrated with behavioral tests and training techniques. Between 1909 and 1913 also the well-known debate on color vision between ophthalmologist Carl von Hess and zoologist Karl von Frisch took place in Naples. Largely unknown is that the debate also concerned cephalopods. A comparative historical analysis of these studies shows how different experimental devices, theoretical frameworks, and personal factors gave rise to two diametrically opposing views. PMID:28066256

  14. Annals of Shanghai Observatory, Academia Sinica

    NASA Astrophysics Data System (ADS)

    Huang, Cheng; Jiang, Dong-Rong; Li, Zhi-Fang; Wan, Ning-Shan; Wang, Lan-Juan; Wang, Jia-Ji; Jiang, Xiao-Yuan; Zhu, Neng-Hong; Xu, Hua-Guan; Li, Zhi-Fang; Yan, Hao-Jian; Jin, Wen-Jing; Zheng, Da-Wei; Liang, Shi-Guang; Huang, Cheng; Fu, Cheng-Qi; Zhai, Zao-Cheng; Tan, De-Tong

    1996-01-01

    This is a report of scientific researches at Shanghai Observatory. Topics presented include achievements in the fields of astro-geodynamics, astrophysics, time and frequency, and development of astronomical instrumentation.

  15. Retraction: Two novel duck antibacterial peptides, avian β-defensins 9 and 10, with antimicrobial activity.

    PubMed

    2013-01-01

    The article by Ma et al. that published in the Journal of Microbiology and Biotechnology (2009, 19: 1447-1455) was used the same data in two journal articles (Acta Veterinaria et Zootechnica Sinica, 2009, 40(9): 1320-1326, Scientia Agricultura Sinica, 2009, 42(4): 1406-1412). Therefore, the article is retracted from JMB as a misconduct of the authors. JMB as the publisher regrets for any inconvenience may have caused by the retraction to readers.

  16. JPRS Report, Science & Technology, China

    DTIC Science & Technology

    1988-11-10

    Plasma-Enhanced CVD Silicon Nitride as Antirefleetion Coating for Silicon Solar Cells 40090008f Beijing TAIYANGNENG XUEBAO [ACTA ENERGIAE SOLARIS SINICA...al.; TAIYANGNENG XUEBAO, No 3, Jul 88] 52 Plasma-Enhanced CVD Silicon Nitride as Antireflection Coating for Silicon Solar Cells [Mao Ganru, et al...130 First Fiber-Optic Line in Jiangxi 130 Solar Power Supply for Fiber-Optic Lines 130 Birefringent Single-Mode Optical Fiber 131 Nanchang

  17. Acta Aeronautica et Astronautica Sinicia (Selected Articles),

    DTIC Science & Technology

    1984-01-04

    target group is I g, C ( ),(:,)..(t,), X’(0) 0 g,<x,(I,)x(,) x,(,)) o The... target groups . II. The Zero Miss Minimum Energy Guidance Law The target group is x I (tf) =0 The other parameters of the terminal are free. Based on...guidance law of the various different systems [3]. III. Guidance Laws of the Target Group as a Zero Control Intercept Curved Surface When

  18. Science, evolution and natural selection: in praise of Darwin at the Stazione Zoologica Anton Dohrn of Naples.

    PubMed

    Ayala, Francisco J

    2015-01-01

    Copernicus, Galileo, Newton and other physical scientists ushered in a conception of the universe as matter in motion governed by natural laws. Their discoveries brought about a fundamental revolution, namely a commitment to the postulate that the universe obeys immanent laws that can account for natural phenomena. The workings of the universe were brought into the realm of science: explanation through natural laws. Darwin completed the Copernican revolution by extending it to the living world. Darwin demonstrated the evolution of organisms. More important yet is that he discovered natural selection, the process that explains the 'design' of organisms. The adaptations and diversity of organisms, the origin of novel and complex species, even the origin of mankind, could now be explained by an orderly process of change governed by natural laws. The origin of species and the exquisite features of organisms had previously been explained as special creations of an omniscient God. Darwin brought them into the domain of science.

  19. Evaluation of Composting Implementation: A Literature Review

    DTIC Science & Technology

    1990-07-13

    Yang. 1987. Properties of TNT- Degrading Enzymes in Intact Cells of Citrobacter -Freundii. Inst. Microbiol., Acad. Sinica, Beijing. Acta Microbiol Sin...27(3): 257-263. 7. Li, W., Y. Yang, and H. Yang. 1989. TNT-Degrading Enzyme of Citrobacter -Freundii and its Regulation by Carbon and Nitrogen Source

  20. The Court Interpreters Act--A Step towards Equal Justice.

    ERIC Educational Resources Information Center

    Barcelo, Cosme J., Jr.

    1979-01-01

    The Court Interpreters Act of 1978, signed by President Carter on October 29, 1978, establishes the right of any individual involved in federal proceedings to have a certified court interpreter if his/her communication or comprehension capabilities are inhibited because of a language barrier or a hearing or speech impairment. (NQ)

  1. JPRS Report, Science & Technology, China.

    DTIC Science & Technology

    2007-11-02

    XUEBAO, Apr 92] 13 Cloning and Expression of Coat Protein Gene of Turnip Mosaic Virus [Qiu Bingsheng, WangJinfang, et ai; WEISHENGWU XUEBAO, Apr...of Coat Protein Gene of Turnip Mosaic Virus 400910171 Beijing WEISHENGWU XUEBAO [ACTA MICROBIOLOGICA SINICAJ in Chinese Vol 32 No 2, Apr 92 pp...Academia Sinica, Beijing] [Text] Turnip mosaic virus (TuMV), a member of the polyvirus group, and considered to be the main virus that cause severe

  2. Translations on People’s Republic of China, No. 467.

    DTIC Science & Technology

    2007-11-02

    his trade with us. 52 The newly established export plants are also instrumental in renovating old plants and in raising our level of production...import new technology and equipment from abroad to renovate the old plants through using subsidy grants, PRC foreign exchange reserves and loans...China. The results in physics are published in Chinese (with English summary) in the periodicals in Acta Physica Sinica and Physica Energiae Fortis

  3. ErbB4 Overexpression as an Antagonist of ErbB2/HER2/Neu Induced Human Breast Cancer Cell Proliferation

    DTIC Science & Technology

    2006-08-01

    Pseudomonas Fluorescens X16L2 and Arbuscular Mycorrhizal (AMF) Glomus mosseae in wheat rhizosphere . Acta Pedologica Sinica. 37: 410-418 Long W., W...University, Department of Microbiology, Wuhan, P. R. China. Dr. Ping Wang, principle investigator. Research Interest: Interactions between Pseudomonas ...Fluorescens X16L2 and Arbuscular Mycorrhizal (AMF) Glomus mosseae in wheat rhizosphere . Honors: Awarded with full scholarship Grant Support

  4. Measurement of radon gas on major faults in California, USA

    USGS Publications Warehouse

    Zhang, W.; King, C.-Y.

    1994-01-01

    Abundant data have been gathered through measurements of radon gas emission in the soil on several major active faults, such as San Andreas and Calaveras, in California, U.S.A.. They show radon emissions and their spatial variations at the unlocked, locked, and creeping sections of faults with different tectonic movements. The characteristics of these variations and the role of fault gases in the research on earthquake prediction are discussed in this paper. ?? 1994 Acta Seismologica Sinica.

  5. Laser Journal (Selected Articles).

    DTIC Science & Technology

    1981-05-01

    optical field at the back focal plane is given by •a ,(u, s,) - Ae- %" + i H (u, V) I e - l’ (1) wrhre H(u,v)is the Fourier transform of the pulse...10 - ~1 automated design programs in general. Design of a Fourier Transform lens with high precision yielded more ideal results. There were also...ents in optical science research, the society still decided to publish "ACTA OPTICA SINICA" and form a editorial board. The administrative body of the

  6. Introduction to a Theory of Language Planning. Acta Universitatis Upsaliensis, Studia Philologiae Scandinavicae Upsaliensia, 6.

    ERIC Educational Resources Information Center

    Tauli, Valter

    Although technical and social engineering and planning have made tremendous progress, an almost prescientific attitude regarding language planning still prevails in some linguistic circles. (Language planning is defined here as the "methodical activity of regulating and improving existing languages or creating new common regional, national or…

  7. Digitalization of "Acta Stomatologica Croatica" Journal (1966;1 - 1999;33).

    PubMed

    Borić, Vesna

    2014-09-01

    Modern documents, scientific articles and books are primarily issued in electronic form and their availability depends on the publisher's, or the document owner's, business ethics. The primary purpose of publishing a scientific article is to communicate with the scientific and professional community; therefore, the published article has to be available worldwide. The question is: Who really needs scientific papers from the 1960's? In cases of brilliant and bold visionaries, new concepts and scientific discoveries often come before their time; hence they have to be "reinvented" decades later. Besides, the scientists of today can enter the spiritual spheres of their professional ancestors and give respect to their legacy.
We have processed more than 1 200 articles published by 1999 and entered more than
6 000 names and surnames of authors.

  8. Digitalization of “Acta Stomatologica Croatica” Journal (1966;1 – 1999;33)

    PubMed Central

    Borić, Vesna

    2014-01-01

    Summary Modern documents, scientific articles and books are primarily issued in electronic form and their availability depends on the publisher's, or the document owner's, business ethics. The primary purpose of publishing a scientific article is to communicate with the scientific and professional community; therefore, the published article has to be available worldwide. The question is: Who really needs scientific papers from the 1960's? In cases of brilliant and bold visionaries, new concepts and scientific discoveries often come before their time; hence they have to be "reinvented" decades later. Besides, the scientists of today can enter the spiritual spheres of their professional ancestors and give respect to their legacy.
We have processed more than 1 200 articles published by 1999 and entered more than
6 000 names and surnames of authors. PMID:27688363

  9. Acoustic Cluster Therapy (ACT)--A novel concept for ultrasound mediated, targeted drug delivery.

    PubMed

    Sontum, Per; Kvåle, Svein; Healey, Andrew John; Skurtveit, Roald; Watanabe, Rira; Matsumura, Manabu; Østensen, Jonny

    2015-11-30

    A novel approach for ultrasound (US) mediated drug delivery - Acoustic Cluster Therapy (ACT) - is proposed, and basic characteristics of the ACT formulation are elucidated. The concept comprises administration of free flowing clusters of negatively charged microbubbles and positively charged microdroplets. The clusters are activated within the target pathology by diagnostic US, undergo an ensuing liquid-to-gas phase shift and transiently deposit 20-30 μm large bubbles in the microvasculature, occluding blood flow for ∼5-10 min. Further application of US will induce biomechanical effects that increases the vascular permeability, leading to a locally enhanced extravasation of components from the vascular compartment (e.g. released or co-administered drugs). Methodologies are detailed for determination of vital in-vitro characteristics of the ACT compound; cluster concentration and size distribution. It is shown how these attributes can be engineered through various formulation parameters, and their significance as predictors of biological behaviour, such as deposit characteristics, is demonstrated by US imaging in a dog model. Furthermore, in-vivo properties of the activated ACT bubbles are studied by intravital microscopy in a rat model, confirming the postulated behaviour of the concept.

  10. Trace metal concentration in Great Tit (Parus major) and Greenfinch (Carduelis sinica) at the Western Mountains of Beijing, China.

    PubMed

    Deng, Haili; Zhang, Zhengwang; Chang, Chongyan; Wang, Yong

    2007-07-01

    We examined the concentrations of 11 trace metals in tissues from 10 body parts of Great Tits and Greenfinches collected at Badachu Park in the Western Mountains of Beijing, China to assess the metal accumulation level, distribution among body parts, and species and gender related variations. The highest concentrations of Hg, Ni, Zn, and Mn were found in the feather; Pb and Co in the bone; Cd, Cr, and Se in the kidney, and Cu in the liver and heart. Metal concentrations had substantial interspecific variation with Great Tits showing higher levels of Hg, Cr, Ni, and Mn than Greenfinches in tissues of most body parts. Gender related variations were body part and species specific. Meta-analyses using data from this study and other studies suggested that metal concentrations of Great Tits at our study site were relatively low and below the toxic levels.

  11. 40Ar/39Ar dating of the Honghuaqiao Formation in SE China

    NASA Astrophysics Data System (ADS)

    Chang, S.; Zhang, H.; Hemming, S. R.; Mesko, G. T.; Fang, Y.

    2010-12-01

    The Jehol Biota, defined as the characteristic Eosestheria-Ephemeropsis-Lycoptera assemblage (Grabau, 1923, Bulletin of the Geological Survey of China), is widely distributed in eastern and central Asia (Li et al., 1982, Acta Geologica Sinica; Chen, 1988, Acta Palaeontologica Sinica). Abundant and varied fossils of the terrestrial Jehol Biota, including plants, insects, dinosaurs, birds, mammals, and freshwater invertebrates, have been discovered from the Dabeigou, the Yixian and the Jiufotang Formations (or their correlative strata) in northeast China from the Liaoning and Hebei Provinces and Inner Mongolia (Chen and Jin, 1999, Acta Palaeontologica Sinica). In addition, strata that may be correlative with the classic Jehol fossil-bearing formations have been identified extensively in central and eastern China, the Korean Peninsula, Mongolia, and Siberia. In the past three decades mollusk, conchostracan, ostracod, insect, fish, and plant fossils from localities in southeastern China, interpreted as related to the Jehol biota of the northeast, have been found (Mateer and Chen, 1986, Cretaceous Research; Li, 2003, Chinese Science Bulletin; Chen, Li and Batten, 2007, Geological Journal). However, a detailed correlation between the classic Jehol outcrops and the more recently found localities to the South and West has yet to emerge. Volcanic rocks from the Honghuaqiao fossil-bearing Formation in Tuzhou City of eastern Anhui Province, southeastern China provide an excellent opportunity to rectify this situation. Preliminary results of a pilot study suggest that the Honghuaqiao Formation is equivalent to the Longwanshan Formation of Anhui Province, southeastern China and the Yixian Formation, northeastern China (Chang et al., 2009, AGU abstract). Initial 40Ar/39Ar results indicate that conchostracans from the upper Honghuaqiao Formation are approximately 130 Ma. Our ongoing work aims to establish a high-resolution chronostratigraphy for Tuzhou City in Anhui Province

  12. Perspectives on Discourse: Proceedings from the 1998 and 1999 Discourse Symposia at Vaxjo University. Acta Wexionesia, No. 2.

    ERIC Educational Resources Information Center

    Virtanen, Tuija, Ed.; Maricic, Ibolya, Ed.

    2000-01-01

    This volume brings together the majority of lectures and papers presented at the 1998 and 1999 discourse symposia at Vaxjo University. Part one, "Four Perspectives on Discourse," offers a matrix perspective on narrative, a cross cultural perspective on academic rhetoric, a cognitive perspective on informational discourse, and a construction…

  13. Comment on "Apatite: A new redox proxy for silicic magmas?" [Geochimica et Cosmochimica Acta 132 (2014) 101-119

    NASA Astrophysics Data System (ADS)

    Marks, Michael A. W.; Scharrer, Manuel; Ladenburger, Sara; Markl, Gregor

    2016-06-01

    Recently Miles et al. (2014) proposed that a negative correlation between oxygen fugacity (expressed as logfO2 and the Mn content of apatite from a range of intermediate to silicic igneous rocks could be used as an oxybarometer (Eq. (1)).

  14. Corrigendum to "The viscosity of planetary tholeiitic melts: A configurational entropy model" [Geochim. Cosmochim. Acta 191 (2016) 277-299

    NASA Astrophysics Data System (ADS)

    Sehlke, Alexander; Whittington, Alan G.

    2017-01-01

    The authors regret some of the information presented in the original article was incorrect. The coefficients for five sub-parameters (s1 to s5) to calculate Sconf in Table 6 are incorrect, which resulted in lower Sconf values, affecting the viscosity prediction near the glass transition temperature (Tg). We provide the correct coefficients (s1 to s5) for in Table 6.

  15. Towards Understanding Leadership in Early Childhood Context: Cross-Cultural Perspectives. Acta Universitatis Ouluensis, E Scientique Rerum Socialium 35.

    ERIC Educational Resources Information Center

    Hujala, Eeva, Ed.; Puroila, Anna-Maija, Ed.

    Recognizing the importance of leadership in determining the quality of early care and education programs, the International Leadership Project (ILP) was initiated in 1996 to develop an understanding of cross-cultural perspectives on leadership, to develop a conceptual framework of leadership, and to develop cross-cultural methodologies for…

  16. Reply to "Comment on papers by K. Shanahan that propose to explain anomalous heat generated by cold fusion", E. Storms, Thermochim. Acta (2005)

    SciTech Connect

    Shanahan, Kirk

    2005-09-21

    Dr. E. Storms has published a Letter [1] in which he argues that in a sequence of recent papers [2-5], the apparent excess heat signal claimed by Dr. Shanahan to arise from a calibration constant shift is actually true excess heat. In particular he proposes that the mechanisms proposed that foster the proposed calibration constant shifts [3,5] cannot occur as postulated for several reasons. As well, he proposes Shanahan has ignored the extant data proving this. Because this Letter may lend unwarranted support to acceptance of cold fusion claims, these erroneous arguments used by Storms need to be answered.

  17. Simposio sobre Educacion de Ninas: Evidencias, Temas, Acciones. Actas de sesiones. (Symposium on Girls Education: Evidence, Issues, Actions. Proceedings). (Washington, DC, May 17-18, 2000).

    ERIC Educational Resources Information Center

    Agency for International Development (IDCA), Washington, DC.

    This symposium highlighted core issues of controversy in girls' education and developed implications for policy and practice. Its evidence-based discussion forum encouraged dialogue, debate, and increased interaction and developed partnerships among academic institutions, nongovernmental organizations, multilateral development agencies, and other…

  18. Erratum to "Combustion oscillation study in a kerosene fueled rocket-based combined-cycle engine combustor" [Acta Astronaut. 129 (2016) 260-270

    NASA Astrophysics Data System (ADS)

    Huang, Zhi-Wei; He, Guo-Qiang; Qin, Fei; Xue, Rui; Wei, Xiang-Geng; Shi, Lei

    2017-03-01

    The publisher regrets that in the above article we found that Table 1 is present online, in the html version in ScienceDirect, but has been omitted in error from the final version of the PDF online and in the print version. The table can be found below:

  19. Reply to comment by Marks et al. (2016) on "Apatite: A new redox proxy for silicic magmas?" [Geochimica et Cosmochimica Acta 132 (2014) 101-119

    NASA Astrophysics Data System (ADS)

    Miles, Andrew; Graham, Colin; Hawkesworth, Chris; Gillespie, Martin; Hinton, Richard; Bromiley, Geoffrey

    2016-06-01

    Marks et al. (2016) investigate the applicability of the Mn-in-apatite oxybarometer proposed by Miles et al. (2014) across a range of magma compositions using published data on well-characterised samples. The authors show that for magma compositions outside of the calc-alkaline and intermediate to silicic range used in the preliminary calibration, fO2 values calculated from Mn-in-apatite vary significantly from independently constrained estimates. These data are used to reiterate our warnings that other controls that are additional to oxygen fugacity are likely to affect Mn partitioning into apatite in some rock types, and particularly so in magmas that lie outside of the range of compositions and conditions used in the calibration. Marks et al. (2016) highlight that temperature may have an especially important effect on Mn partitioning in apatite in some rock types.

  20. Tiny tweaks, big changes: An alternative strategy to empower ethical culture of human research in anesthesia (A Taiwan Acta Anesthesiologica Taiwanica-Ethics Review Task Force Report).

    PubMed

    Luk, Hsiang-Ning; Ennever, John F; Day, Yuan-Ji; Wong, Chih-Shung; Sun, Wei-Zen

    2015-03-01

    For this guidance article, the Ethics Review Task Force (ERTF) of the Journal reviewed and discussed the ethics issues related to publication of human research in the field of anesthesia. ERTF first introduced international ethics principles and minimal requirements of reporting of ethics practices, followed by discussing the universal problems of publication ethics. ERTF then compared the accountability and methodology of several medical journals in assuring authors' ethics compliance. Using the Taiwan Institutional Review Board system as an example, ERTF expressed the importance of institutional review board registration and accreditation to assure human participant protection. ERTF presented four major human research misconducts in the field of anesthesia in recent years. ERTF finally proposed a flow-chart to guide journal peer reviewers and editors in ethics review during the editorial process in publishing. Examples of template languages applied in the Ethics statement section in the manuscript are expected to strengthen the ethics compliance of the authors and to set an ethical culture for all the stakeholders involved in human research.

  1. Curriculum Perspectives: Challenges for the Future. Proceedings of a Binational Symnposium = Perspectivas curriculares: Retos para el futuro. Actas del simposio binacional (Austin, Texas, November 9-10, 1994).

    ERIC Educational Resources Information Center

    Southwest Educational Development Lab., Austin, TX.

    This proceedings, in English and Spanish, describes the first U.S./Mexico Curriculum Symposium, held in Austin, Texas, in November 1994. The symposium grew out of an ongoing exchange between educators in the Republic of Mexico and the United States and was attended by over 200 teachers, administrators, staff from state and regional education…

  2. Corrigendum to "Equilibrium magnesium isotope fractionation between aqueous Mg2+ and carbonate minerals: Insights from path integral molecular dynamics" [Geochim. Cosmochim. Acta 163 (2015) 126-139

    NASA Astrophysics Data System (ADS)

    Pinilla, Carlos; Blanchard, Marc; Balan, Etienne; Natarajan, Suresh K.; Vuilleumier, Rodolphe; Mauri, Francesco

    2015-10-01

    The theoretical 26Mg/24Mg β-factor of aqueous Mg2+ of Schauble (2011) has been reported with an error in Pinilla et al. (2015). The corresponding value in Table 7 is incorrect and should read 25.5‰ at 298 K. In Section 3.6 (page 133), one sentence is affected and should be rephrased as: "It is noteworthy that the estimate of the Mg(aq)β-factor from a set of salts containing the Mg(H20)62+ complex leads to a value ∼2‰ higher than the other estimates at 298 K." Finally, the curves in Fig. 8 corresponding to the calculations of Schauble (2011) have been corrected in the figure below.

  3. Lithostratigraphy and depositional history of the Late Cenozoic hominid-bearing successions in the Yuanmou Basin, southwest China

    NASA Astrophysics Data System (ADS)

    Urabe, Atsushi; Nakaya, Hideo; Muto, Tetsuji; Katoh, Shigehiro; Hyodo, Masayuki; Shunrong, Xue

    2001-09-01

    Late Cenozoic strata bearing hominids and hominoids are distributed in the Yuanmou Basin, Yunnan, southwest China. Incisors of Homo erectus discovered in these strata in 1965 reportedly show primitive features known in Africa (Hu, Acta geologica sinica 1 (1973, p. 65). However, recent paleomagnetic study has revealed that the age of the hominid correlates to the early Brunhes chron (Hyodo et al., Journal of human evolution (2001), submitted). The lithostratigraphy of the successions that yield many mammalian fossils including those of the hominid, and the record of Equus is re-examined. The successions are divided in ascending order into the Longchuan, Shagou, Gantang (newly proposed Yangliuchun and Daipojing Members) and Yuanmou (newly proposed Dainawu and Niujianbao Members) Formations, based on different lithology and sedimentary facies. The newly proposed depositional systems of the formations are in ascending order, alluvial fan, ephemeral braided river, sandy braided river, ephemeral gravelly braided river and alluvial fan systems. The change in facies and paleocurrents revealed in the successions suggest that the basin was initiated as a syncline basin at ca 3.5 Ma and was completed as an asymmetric half graben by active movement of the eastern marginal fault in the early Middle Pleistocene.

  4. RETRACTED: The influence of sand diameter and wind velocity on sand particle lift-off and incident angles in the windblown sand flux

    NASA Astrophysics Data System (ADS)

    Bo, Tian-Li; Zheng, Xiao-Jing; Duan, Shao-Zhen; Liang, Yi-Rui

    2013-05-01

    This article has been retracted: please see Elsevier Policy on Article Withdrawal. This article has been retracted at the request of the Editors-in-Chief. This article also contains significant similarity with parts of text, written by the same author(s), that have appeared in Tian-Li Bo, Xiao-Jing Zheng, Shao-Zhen Duan, Yi-Rui Liang, The influence of wind velocity and sand grain diameter on the falling velocities of sand particles, Powder Technology, Volume 241, June 2013, Pages 158-165. Tian-Li Bo, Xiao-Jing Zheng, Shao-Zhen Duan, Yi-Rui Liang, Analysis of sand particles' lift-off and incident velocities in wind-blown sand flux, Acta Mechanica Sinica, April 2013, Volume 29, Issue 2, pp 158-165. Tian-Li Bo, Xiao-Jing Zheng, Shao-Zhen Duan, Yi-Rui Liang, Influence of sand grain diameter and wind velocity on lift-off velocities of sand particles, The European Physical Journal E, May 2013, 36:50. Tian-Li Bo, Shao-Zhen Duan, Xiao-Jing Zheng, Yi-Rui Liang, The influence of sand bed temperature on lift-off and falling parameters in windblown sand flux, Geomorphology, Volume 204, 1 January 2014, Pages 477-484. The scientific community takes a very strong view on this matter and apologies are offered to readers of the journal that this was not detected during the submission process.

  5. Suppression of generalized oscillator strengths in particular kinematic situations

    NASA Astrophysics Data System (ADS)

    Avdonina, N. B.; Pratt, R. H.

    2002-05-01

    We find suppression of generalized oscillator strengths (GOS) in electron excitation and ionization at small angles in various atomic targets, including excited atoms and ions, in particular kinematic situations. The suppression occurs in optically allowed transitions, and the reason for the effect is the same as for the existence of Cooper minima for these transitions in the photo processes. Since at small momentum transfer Q the dipole approximation is valid (independent of the approximation made for the incident and scattered electrons) GOSs are proportional to the optical oscillator strengths (OOS). Minima of the scattering matrix elements, corresponding to the Cooper minima of OOS, exist and do not depend on energy transfer in a large range of small Q [1,2]. We note also that many-electron correlations are very important in the calculation of small angle GOSs in the cases considered. We contrast our results with other findings. 1. X-M. Tong, L. Yang and J.-M. Li, Acta Physica Sinica 38, 398 (1989). 2. N.B. Avdonina, Msezane, A.Z., and Pratt, R.H., International Conference on Photonic, Electronic and Atomic Collisions (ICPEAC), Santa Fe (New Mexico, USA) July 18 - 24 (2001), Abstracts.

  6. Existence of almost periodic solutions for forced perturbed systems with piecewise constant argument

    NASA Astrophysics Data System (ADS)

    Xia, Yonghui; Huang, Zhenkun; Han, Maoan

    2007-09-01

    Certain almost periodic forced perturbed systems with piecewise argument are considered in this paper. By using the contraction mapping principle and some new analysis technique, some sufficient conditions are obtained for the existence and uniqueness of almost periodic solution of these systems. Furthermore, we study the harmonic and subharmonic solutions of these systems. The obtained results generalize the previous known results such as [A.M. Fink, Almost Periodic Differential Equation, Lecture Notes in Math., volE 377, Springer-Verlag, Berlin, 1974; C.Y. He, Almost Periodic Differential Equations, Higher Education Press, Beijing, 1992 (in Chinese); Z.S. Lin, The existence of almost periodic solution of linear system, Acta Math. Sinica 22 (5) (1979) 515-528 (in Chinese); C.Y. He, Existence of almost periodic solutions of perturbation systems, Ann. Differential Equations 9 (2) (1992) 173-181; Y.H. Xia, M. Lin, J. Cao, The existence of almost periodic solutions of certain perturbation system, J. Math. Anal. Appl. 310 (1) (2005) 81-96]. Finally, a tangible example and its numeric simulations show the feasibility of our results, the comparison between non-perturbed system and perturbed system, the relation between systems with and without piecewise argument.

  7. Corrigendum to "Basin-scale controls on the molybdenum-isotope composition of seawater during Oceanic Anoxic Event 2 (Late Cretaceous)" [Geochim. Cosmochim. Acta 178 (2016) 291-306

    NASA Astrophysics Data System (ADS)

    Dickson, Alexander J.; Jenkyns, Hugh C.; Porcelli, Donald; van den Boorn, Sander; Idiz, Erdem; Owens, Jeremy D.

    2016-09-01

    A recent molybdenum-isotope estimate of the extent of anoxic and euxinic conditions in the world ocean during Oceanic Anoxic Event 2 (∼94 Ma) concluded by discussing a contrast between the new results with existing estimates of marine euxinia based on sulphur isotopes. This suggested contrast was erroneous; when areal extents of marine anoxia and euxinia are calculated for both isotopic proxies, the agreement is actually striking, and highlights the fact that large areas of the global ocean probably remained well ventilated during this event.

  8. Erratum to "A novel strategy for spectrophotometric simultaneous determination of amitriptyline and nortriptyline based on derivation with a quinonoid compound in serum samples" [Spectrochim. Acta A Mol. Biomol. Spectrosc. 168, 2016, 235-243

    NASA Astrophysics Data System (ADS)

    Farnoudiyan-Habibi, Amir; Massoumi, Bakhshali; Jaymand, Mehdi

    2017-04-01

    The authors regret that the surname of author Amir Farnoudiyan-Habibi was misspelt as Amir Farnoudian-Habibi. In addition, the affiliation for the author was incorrect and should have been ;Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, P.O. Box: 5157944533, Tabriz, Islamic Republic of Iran;.

  9. Western Hemisphere Conference on Persons with Disabilities. Conference Proceedings (Washington, D.C., March 14-18, 1993) = Conferencia Hemisferica Occidental sobre Personas con Discapacidades. Actas de la Conferencia. (Washington, D.C., 14 al 18 de Marzo de 1993).

    ERIC Educational Resources Information Center

    Kelley, Jerry D., Ed.; And Others

    This document presents the proceedings of a conference which brought together delegates and First Ladies representing western hemisphere nations to address needs and issues affecting people with disabilities in the Americas. It presents the texts of two keynote addresses: "Small Triumphs, Big Victories: A Global View of Persons with…

  10. Comments on "Synthesis aspects, structural, spectroscopic, antimicrobial and room temperature ferromagnetism of zinc iodide complex with Schiff based ligand" by K. Shakila and S. Kalainathan, Spectrochim. Acta 135 A (2015) 1059-1065

    NASA Astrophysics Data System (ADS)

    Srinivasan, Bikshandarkoil R.; Nadkarni, V. S.

    2016-06-01

    Shakila and Kalainathan report on the synthetic and structural aspects of a zinc iodide complex with Schiff based ligand, which exhibits room temperature ferromagnetism. In this comment, many points of criticism, concerning the characterization of this so called zinc iodide complex of Schiff based ligand are highlighted to prove that the title paper is completely erroneous.

  11. Corrigendum to "Historical review: Anders Jonas Ångström and the foundation of spectroscopy - Commemorative article on the second centenary of his birth" [Spectrochim. Acta Part B, 102 (2014) 12-23

    NASA Astrophysics Data System (ADS)

    Reif-Acherman, Simón

    2015-07-01

    The following addendum should be added to the Acknowledgments of the above article. Due to the multiplicity of simultaneous activities in which I am continuously involved, I forgot mentioning that Prof. Dr. Klaus Hentschel, of the History Department of the University of Stuttgart (Germany) was helpful in obtaining some of the source material used in my review. In particular, Prof. Hentschel provided the scans of Anne Beckmann's work to which I was guided by passages in his book on "Mapping the spectrum", Oxford University Press (2002). I also followed his recommendation of contacting the Swedish historians of science, and Prof. Sven Widmalm among them; however, the correspondence was not successful.

  12. Corrigendum to "Isotopic and geochemical characterization of fossil brines of the Cambrian Mt. Simon sandstone and Ironton-Galesville formation from the Illinois Basin, USA" [Geochim. Cosmochim. Acta 165 (2015) 342-360

    NASA Astrophysics Data System (ADS)

    Labotka, Dana M.; Panno, Samuel V.; Locke, Randall A.; Freiburg, Jared T.

    2016-08-01

    The original Fig. 4 incorrectly represented data from Clayton et al. (1966). The deuterium values were reported in percent deuterium and mistaken by the authors as per mille. The corrected Fig. 4 Corrigendum is given and shows the data from Clayton et al. (1966) plotting in a similar manner as other published data for groundwater in the Illinois Basin. The data from Clayton et al. (1966) was not used in the discussion of the deep-seated Cambrian brines, and, therefore, this misrepresentation does not affect the conclusions of the original manuscript. The authors apologize for the oversight.

  13. Corrigendum to ‘Evidence for shock heating and constraints on Martian surface temperatures revealed by 40Ar/39Ar thermochronometry of Martian meteorites’ [Geochim. Cosmochim. Acta (2010) 6900–6920

    DOE PAGES

    Cassata, William S.; Shuster, David L.; Renne, Paul R.; ...

    2014-10-23

    Here, the authors regret they have discovered errors in Eq. (3) and in a spreadsheet used to calculate cosmogenic exposure ages shown in Table 1. Eq. (3) is missing a term. The spreadsheet errors concerned an incorrect cell reference and application of Eq. (3). Correction of these errors results in ~15–20% changes to the exposure ages of all samples, minor (generally <0.2%) changes to the radioisotopic ages of some samples (those that entailed a correction for chlorine-derived 38Ar calculated based on the exposure age; see Section 3.3), and statistically insignificant changes to the inferred trapped components identified through isochron analyses.more » These modifications have no impact on the modeling, discussions, or conclusions in the paper, nor do the changes to radioisotopic ages exceed the 1 sigma uncertainties.« less

  14. Corrigendum to ‘Evidence for shock heating and constraints on Martian surface temperatures revealed by 40Ar/39Ar thermochronometry of Martian meteorites’ [Geochim. Cosmochim. Acta (2010) 6900–6920

    SciTech Connect

    Cassata, William S.; Shuster, David L.; Renne, Paul R.; Weiss, Benjamin P.

    2014-10-23

    Here, the authors regret they have discovered errors in Eq. (3) and in a spreadsheet used to calculate cosmogenic exposure ages shown in Table 1. Eq. (3) is missing a term. The spreadsheet errors concerned an incorrect cell reference and application of Eq. (3). Correction of these errors results in ~15–20% changes to the exposure ages of all samples, minor (generally <0.2%) changes to the radioisotopic ages of some samples (those that entailed a correction for chlorine-derived 38Ar calculated based on the exposure age; see Section 3.3), and statistically insignificant changes to the inferred trapped components identified through isochron analyses. These modifications have no impact on the modeling, discussions, or conclusions in the paper, nor do the changes to radioisotopic ages exceed the 1 sigma uncertainties.

  15. Actas de la 4th mesa redonda sobre investigacion en "Lenguas Extranjeras" en la Universidad Autonoma Metropolitana 1996. (Proceedings from the 4th Roundtable on Investigation in Foreign Languages in the Autonomous Metropolitan University 1996).

    ERIC Educational Resources Information Center

    Zoreda, Margaret Lee, Comp.; Diop, Mamoudou Si, Comp.; Vivaldo Lima, Javier, Comp.

    The articles included in this volume were selected as exemplary papers from the conference in Mexico. The goal of the forum was to provide an opportunity for researchers from the three branches of the Universidad Autonoma Metropolitana (UAM) to meet and discuss research projects currently in progress at the university. The works presented here…

  16. Corrigendum to 'Evidence for shock heating and constraints on Martian surface temperatures revealed by 40Ar/39Ar thermochronometry of Martian meteorites' [Geochim. Cosmochim. Acta (2010) 6900-6920

    NASA Astrophysics Data System (ADS)

    Cassata, William S.; Shuster, David L.; Renne, Paul R.; Weiss, Benjamin P.

    2015-01-01

    The authors regret they have discovered errors in Eq. (3) and in a spreadsheet used to calculate cosmogenic exposure ages shown in Table 1. Eq. (3) is missing a term. The spreadsheet errors concerned an incorrect cell reference and application of Eq. (3). Correction of these errors results in ∼15-20% changes to the exposure ages of all samples, minor (generally <0.2%) changes to the radioisotopic ages of some samples (those that entailed a correction for chlorine-derived 38Ar calculated based on the exposure age; see Section 3.3), and statistically insignificant changes to the inferred trapped components identified through isochron analyses. These modifications have no impact on the modeling, discussions, or conclusions in the paper, nor do the changes to radioisotopic ages exceed the 1 sigma uncertainties.

  17. Reply to "Methane origin in the Samail ophiolite: Comment on 'Modern water/rock reactions in Oman hyperalkaline peridotite aquifers and implications for microbial habitability'" [Geochim. Cosmochim. Acta 179 (2016) 217-241

    NASA Astrophysics Data System (ADS)

    Miller, Hannah M.; Matter, Jürg M.; Kelemen, Peter; Ellison, Eric T.; Conrad, Mark; Fierer, Noah; Ruchala, Tyler; Tominaga, Masako; Templeton, Alexis S.

    2017-01-01

    We thank Dr. Giuseppe Etiope for his comment and the opportunity to further discuss why we consider the origin of the methane detected in subsurface fluids obtained from a peridotite aquifer in Oman to be enigmatic.

  18. Methane origin in the Samail ophiolite: Comment on "Modern water/rock reactions in Oman hyperalkaline peridotite aquifers and implications for microbial habitability" [Geochim. Cosmochim. Acta 179 (2016) 217-241

    NASA Astrophysics Data System (ADS)

    Etiope, Giuseppe

    2017-01-01

    Miller et al. (2016) report a new study of fluids in the peridotites of the Samail ophiolite in Oman related to modern serpentinization (olivine hydration), a process that can provide energy and raw materials for chemosynthetic microbial life. The authors, in particular, report an isotopic composition for methane (CH4) in groundwater near Ibra (up to 1.4 mM) that is unusually 13C-enriched (δ13CCH4 ∼ +2.4 and +3‰ VPDB), and consider the gas origin to be uncertain, i.e., abiotic or microbial, and to be modulated by significant fractionation due to oxidation or diffusion. The purpose of this comment is to clarify and correct a few points concerning the possible origin of the δ13CCH4 values, with the intention to promote a fruitful and constructive debate, considering the interest that there is for serpentinization and the associated formation of various gases.

  19. Coping with Social Change: Programs That Work. Proceedings of a Conference (Acapulco, Mexico, June 1989) = Como enfrentarse al cambio social: programas eficaces. Actas de uno Conferencia (Acapulco, Mexico, Junio de 1989).

    ERIC Educational Resources Information Center

    Hoskins, Irene, Ed.

    Written in English and Spanish, this document contains the proceedings of the 14th International Congress of Gerontology on concerns about the impact of rapid social change on the well-being of older women and families in Latin American and the Caribbean and about effective programs that address the needs of the older populations. The first…

  20. Corrigendum to "Synthesis and spectral characterization of new homologous 1,3,5-triaryl-2-pyrazolines: Influence of alkyloxy chain length on fluorescence" [Spectrochim. Acta Part A: Mol. Biomol. Spectrosc. 133 (2014) 182-189

    NASA Astrophysics Data System (ADS)

    Abbas, Asghar; Hussain, Safdar; Hafeez, Noureen; Naseer, Muhammad Moazzam

    2015-03-01

    The authors regret to inform that the affiliation of one of the authors, namely, Noureen Hafeez has been written as Department of Forensic Medicine & Toxicology, Rawalpindi Institute of Health Sciences (RIHS), Bahria University, Islamabad, Pakistan in the published article. The correct address is shown above.

  1. Comment on "Assessment of new DFT methods for predicting vibrational spectra and structure of cisplatin: Which density functional should we choose for studying platinum(II) complexes?" [Spectrochim. Acta A125 (2014) 431-439

    NASA Astrophysics Data System (ADS)

    Marques, Maria Paula M.; Batista de Carvalho, Luis A. E.; Parker, Stewart F.

    2015-02-01

    As researchers in the field of Pt(II) and Pd(II) compounds as potential anticancer agents, we were surprised by the recent paper by Malik and Michalska (hereafter MM) on the application of DFT methods to cisplatin

  2. WITHDRAWN: Corrigendum to "High-sensitive cardiac troponin I (hs-cTnl) values in patients with stable cardiovascular disease: An initial foray" [Clinica Chimica Acta 411 (2010) 812--817].

    PubMed

    Schulz, Olaf; Reinicke, Markus; Berghoefer, Gunnar H; Bensch, Ricarda; Kraemer, Jochen; Schimke, Ingolf; Jaffe, Allan S

    2010-05-18

    This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

  3. Comment on "Behavior of Re and Os during contact between an aqueous solution and oil: Consequences for the application of the Re-Os geochronometer to petroleum" [Geochim. Cosmochim. Acta 158 (2015) 1-21

    NASA Astrophysics Data System (ADS)

    Wu, Jia; Li, Zhen; Wang, Xuan-ce

    2016-08-01

    In a recent study, Mahdaoui et al. (2015) simulated the contact of oil with Re/Os-bearing aqueous fluids in petroleum reservoirs and concluded that both metals could be rapidly and substantially enriched in the oil fraction. These findings could have significant geological ramifications for the use of rhenium-osmium (Re-Os) geochronology in the age-dating of oil deposits. However, the lack of data reproducibility between parallel experiments and misused parameter of "recovery rate" has cast doubt on the main conclusions of the paper. Re-analyses of the raw data provided sufficient evidence to suggest that in petroleum basins with very low abundances of Re and Os, the extraction of these metals to oil is unlikely to be a geologically instantaneous process as the authors implied in their study. In addition, the possibility of reactor leakage in the contacting experiments cannot be completely ruled out.

  4. Corrigendum to "Recycling of crustal material by the Iceland mantle plume: New evidence from nitrogen elemental and isotope systematics of subglacial basalts" [Geochim. Cosmochim. Acta 176 (2016) 206-226

    NASA Astrophysics Data System (ADS)

    Halldórsson, Sæmundur A.; Hilton, David R.; Barry, Peter H.; Füri, Evelyn; Grönvold, Karl

    2016-08-01

    In Table 1 of the above published paper, N2/40Ar* ratios (column 13) are incorrect. A corrected table and updated figures (Figs. 6-8) are shown below. The correct N2/40Ar* values vary between 178 and 2.6 × 104, with a mean of 4.1 ± 2.1 (×103). Although this range in N2/40Ar* ratios is somewhat smaller compared to what was reported, it still displays considerably more heterogeneity compared to the DMM database. The new mean value is also significantly higher than the DMM mean (138 ± 65), as discussed. Therefore, the findings in the paper concerning heterogeneous and elevated N2/40Ar* ratios in Icelandic subglacial basalts still stand.

  5. Corrigendum to "Pharmaceutical analysis in solids using front face fluorescence spectroscopy and multivariate calibration with matrix correction by piecewise direct standardization" [Spectrochim. Acta Part A: Mol. Biomol. Spectrosc. 103 (2013) 311-318

    NASA Astrophysics Data System (ADS)

    Alves, Julio Cesar L.; Poppi, Ronei J.

    2014-03-01

    The authors regret to inform that the tick labels of the ternary diagram axes in Fig. 1 were shown from 0% to 1.0% instead of 0% to 100%. The correct values of 0% to 100% are shown in the corrected Fig. 1 (see below). The right contents of the active ingredients in the sample sets shown in the diagram are now in agreement with the stated throughout the paper.

  6. Derechos Educacionales de los Padres: Una Explicacion de los Procedimientos de Seguridad para los Padres de Ninos con Discapacidades. Bajo la Clausula del Acta de Educacion para Individuos con Discapacidades (IDEA) y las Reglas para la Administracion del Acta de Educacion para Ninos Excepcionales (Educational Rights of Parents: An Explanation of Procedural Safeguards Available to Parents of Children with Disabilities. Under Provisions of the Individuals with Disabilities Education Act (IDEA) and the Rules for the Administration of the Exceptional Children's Educational Act [ECEA]).

    ERIC Educational Resources Information Center

    Mountain Plains Regional Resource Center, Des Moines, IA.

    This pamphlet, in Spanish, describes Colorado parents' educational rights under federal and state special education rules and regulations. It addresses: (1) free appropriate public education and termination of services; (2) required prior notice to parents if there is a proposed change or refusal to change a child's special education program; (3)…

  7. RETRACTED: The influence of sand bed temperature on lift-off and falling parameters in windblown sand flux

    NASA Astrophysics Data System (ADS)

    Bo, Tian-Li; Duan, Shao-Zhen; Zheng, Xiao-Jing; Liang, Yi-Rui

    2014-01-01

    This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy) This article has been retracted at the request of the Editors-in-Chief. This article also contains significant similarity with parts of text, written by the same author(s), that have appeared in Tian-Li Bo, Xiao-Jing Zheng, Shao-Zhen Duan, Yi-Rui Liang, The influence of sand diameter and wind velocity on sand particle lift-off and incident angles in the windblown sand flux, Sedimentary Geology, Volume 290, 15 May 2013, Pages 149-156. Tian-Li Bo, Xiao-Jing Zheng, Shao-Zhen Duan, Yi-Rui Liang, The influence of wind velocity and sand grain diameter on the falling velocities of sand particles, Powder Technology, Volume 241, June 2013, Pages 158-165. Tian-Li Bo, Xiao-Jing Zheng, Shao-Zhen Duan, Yi-Rui Liang, Analysis of sand particles' lift-off and incident velocities in wind-blown sand flux, Acta Mechanica Sinica, April 2013, Volume 29, Issue 2, pp 158-165. Tian-Li Bo, Xiao-Jing Zheng, Shao-Zhen Duan, Yi-Rui Liang, Influence of sand grain diameter and wind velocity on lift-off velocities of sand particles, The European Physical Journal E, May 2013, 36:50. The "slicing" of research that would form one meaningful paper into several different papers represents an abuse of the scientific publishing system. The scientific community takes a very strong view on this matter and apologies are offered to readers of the journal that this was not detected during the submission process.

  8. CROSS-DISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY: The structural analysis of protein sequences based on the quasi-amino acids code

    NASA Astrophysics Data System (ADS)

    Zhu, Ping; Tang, Xu-Qing; Xu, Zhen-Yuan

    2009-01-01

    Proteomics is the study of proteins and their interactions in a cell. With the successful completion of the Human Genome Project, it comes the postgenome era when the proteomics technology is emerging. This paper studies protein molecule from the algebraic point of view. The algebraic system (Σ, +, *) is introduced, where Σ is the set of 64 codons. According to the characteristics of (Σ, +, *), a novel quasi-amino acids code classification method is introduced and the corresponding algebraic operation table over the set ZU of the 16 kinds of quasi-amino acids is established. The internal relation is revealed about quasi-amino acids. The results show that there exist some very close correlations between the properties of the quasi-amino acids and the codon. All these correlation relationships may play an important part in establishing the logic relationship between codons and the quasi-amino acids during the course of life origination. According to Ma F et al (2003 J. Anhui Agricultural University 30 439), the corresponding relation and the excellent properties about amino acids code are very difficult to observe. The present paper shows that (ZU, ⊕, otimes) is a field. Furthermore, the operational results display that the codon tga has different property from other stop codons. In fact, in the mitochondrion from human and ox genomic codon, tga is just tryptophane, is not the stop codon like in other genetic code, it is the case of the Chen W C et al (2002 Acta Biophysica Sinica 18(1) 87). The present theory avoids some inexplicable events of the 20 kinds of amino acids code, in other words it solves the problem of 'the 64 codon assignments of mRNA to amino acids is probably completely wrong' proposed by Yang (2006 Progress in Modern Biomedicine 6 3).

  9. CPTAC Establishes Formal Relationships with Two Academic Institutions in Taiwan - Office of Cancer Clinical Proteomics Research

    Cancer.gov

    The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium (CPTAC) has entered into memorandum of understandings (MOUs) with Chang Gung University and Academia Sinica, in Taipei, Taiwan.

  10. An appreciation of Christiane Groehen: the correspondence between Charles Darwin and Anton Dohrn.

    PubMed

    Browne, Janet

    2015-01-01

    Anton Dohrn was introduced to Darwinism by Ernst Haeckel during his student years at Jena, and became an eager disciple of Charles Darwin's work. He founded the Stazione Zoologica in 1872. Darwin became a patron of Dohrn's Stazione, and the two naturalists corresponded regularly. This article discusses their relationship and the contributions of Christiane Groeben to its elucidation.

  11. Detrital zircon U-Pb geochronology and provenance of the Carboniferous-Permian glaciomarine pebbly slates in the Tibetan Plateau

    NASA Astrophysics Data System (ADS)

    Wang, Q.; Zhu, D.; Zhao, Z.; Chung, S.; Li, C.; Sui, Q.; Fu, X.; Mo, X.

    2011-12-01

    from different terranes of the Tibetan Plateau. Such difference may have been associated primarily with the different paleogeographical positions of the Lhasa Terrane that was adjacent to northern Australia and of the Qiangtang and Tethyan Himalaya terranes that were situated in the northern margin of the Indian continent, respectively. [Financially supported by the National Key Project for Basic Research of China (2011CB403102), the Chinese National Natural Science Foundation (41073013 and 40830317), and the Programme of the China Geological Survey (1212011121260 and 1212011121066)]. Zhu, D.C., et al., 2011a. Geology 39, 727-730. Zhu, D.C., et al., 2011b. Acta Petrologica Sinica 27, 1917-1930.

  12. On searching applicants for mechanism of solar-lithosphere relations

    NASA Astrophysics Data System (ADS)

    Kairatkyzy, Dina; Andreyev, Alexey; Zhumabayeva, Saltanat; Seraliyev, Alibek

    2016-04-01

    It is actively discussed at present a question on possible influence of solar activity (high-speed solar wind streams bearing the "frozen" magnetic field lines of the Sun) on the stress status of the lithosphere and, consequently, on the Earth's seismic activity (e.g. Zhang, 1998, Acta Seismologica Sinica; Khachikyan et al., EGU2016-2754-1; IUGG2015-3132). There are at least two ideas on possible applicants for physical mechanism of solar-lithosphere relations: (i) - the muons of cosmic rays, which can penetrate the Earth's crust to a depth of at least the first ten kilometers and in tense seismic environment generate nuclear-electromagnetic cascade which energy can be a trigger of earthquake (Tsarev and Chechin, 1988, Preprint № 179, Physical Institute after Lebedev, Moscow); (ii) - the geomagnetic storms (Sobolev et al., 1998, Physics of the Earth #7) when the high-frequency oscillations of the geomagnetic field during the main phase of the storm generate significant induction currents which electric energy entering into the crust can be converted into mechanical energy increasing the stress status of the lithosphere (Sobolev and Demin, Mechano-electric phenomena into the Earth. M . Nauka. 1980). Besides this, among the possible cosmogenic factors changing the stress state of the lithosphere, could be the variation of the angular velocity of rotation of the Earth (e.g. Bostrom, 2000. Tectonic consequence of the Earth's Rotation), if it depends on solar activity variations. More of 50 years ago, Munk and Donald (The Rotation of the Earth, Cambrige University Press, 1960) suggested that the interaction between solar wind and geomagnetic field would probably influence the short period variation of angular velocity of the Earth. In this work, we check up this suggestion on the base of very precise data on the length of day (LOD) from 1986 to the present, which are presented by the International Earth Rotation and Reference Systems Service (IERS). Using the methods

  13. Flameless Atomic Absorption Spectroscopy: Effects of Nitrates and Sulfates.

    DTIC Science & Technology

    1980-05-01

    oxide by graphite followed by sublimation of the metal. Frech and Cedergren investigated high temperature equilibria in graphite furnace atomizers. 1 4...Acta, 72, 49 (1974). 13. R.E. Sturgeon, C.L. Chakrabarti, and C.H. Langford, Anal. Chem., 48, 1792 (1976). 14. W. Frech and A. Cedergren , Anal. Chim...Acta, 82, 83 (1976). 15. W. Frech, Anal. Chim. Acta, 77, 43 (1975). 16. W. Frech and A. Cedergren , Anal. Chim. Acta, 88, 57 (1977). CHAPTER III

  14. Adaptive continuous twisting algorithm

    NASA Astrophysics Data System (ADS)

    Moreno, Jaime A.; Negrete, Daniel Y.; Torres-González, Victor; Fridman, Leonid

    2016-09-01

    In this paper, an adaptive continuous twisting algorithm (ACTA) is presented. For double integrator, ACTA produces a continuous control signal ensuring finite time convergence of the states to zero. Moreover, the control signal generated by ACTA compensates the Lipschitz perturbation in finite time, i.e. its value converges to the opposite value of the perturbation. ACTA also keeps its convergence properties, even in the case that the upper bound of the derivative of the perturbation exists, but it is unknown.

  15. Microinclusion of Lower-Mantle Rock in Diamond

    NASA Astrophysics Data System (ADS)

    Kaminsky, Felix; Wirth, Richard

    2014-05-01

    A microinclusion of a rock fragment was identified within one of the diamonds from the Rio Soriso placer deposit in the Juina area, Brazil. It is composed of iron carbide, magnesiowüstite and two orthorhombic, postspinel phases, Fe-Mg-Cr and Ca-Cr oxides. All mineral grains are closely intergrown, demonstrating their single-stage origin, except iron carbide, which is partly resorped that implies its early crystallization. Diffraction patterns of iron carbide grains reveal two mineral species, nitrogen-containing analogues of chalypite Fe7C3 (or Fe2C) [1] and yarlongite Fe9C4 [2]. They contain up to 17.5 at.% of N in the cation part (N/(C+N) = 0.47) and should be considered as nitrocarbides. In addition to N, admixtures of O and Si present in these mineral species. Magnesiowüstite has, in its cation composition, 47.75-67.16 at.% Fe, 36.72-47.75 at.% Mg, and minor admixtures of Mn and Cr. Among the two new oxides with orthorhombic structure, one is a polymorph of chromite (Fe2+,Mg,Mn) (Cr,Fe3+,Al,V)2O4, which is new in terrestrial environment. It is analogues to xieite, found in the Suizhou meteorite [3], but strongly enriched in Fe. The other orthorhombic mineral fits the stoichiometry Ca(Cr,Fe3+)2O4. This compound is new in the natural environment; the CaCr2O4 postspinel phase is known only as a synthetic compound [4]. The studied association was formed within the lower mantle at pressure conditions above 40 GPa (that correspond to the formation of CaTi2O4 [5]). The presence of magnesiowüstite and chalypite suggests the rock origin in the lower part of the lower mantle. References: Kaminsky, F.V., Wirth, R. (2011) Iron carbide inclusions in lower-mantle diamond from Juina, Brazil. Canadian Mineralogist 49(2), p. 555-572. Shi, N., Bai, W., Li, G., Xiong, M., Fang, Q., Yang, J., Ma, Z., Rong, H. (2009) Yarlongite: A new metallic carbide mineral. Acta Geologica Sinica 83(1), 52-56. Chen, M., Shu, J., Mao, H.-k. (2008) Xieite, a new mineral of high-pressure FeCr2O4

  16. In situ SIMS oxygen isotope analysis of olivine in the Tibetan mantle xenoliths

    NASA Astrophysics Data System (ADS)

    Zhao, Zhidan; Zhu, Di-Cheng; Liu, Dong; Mo, Xuanxue

    2016-04-01

    around 90, but also as low as Fo of 70; (4) In olivine crystals in mantle xenolith, the oxygen isotopes in rim (δ18O=6.96-7.98‰ Fo#=78-82) significantly shift to high δ18O values that similar to their neighboring lava olivine phenocrysts (δ18O=8.03‰ Fo# =80). These data suggest that the oxygen isotopes in mantle xenolith olivines are more stable during the processes of metasomatism. The mantle xenolith may have been metasomatized by the host lava, in addition to other enriched reservoir in the sub-arc mantle. [Financially supported by the NSF of China, grants 41273044, 41225006, 41230209, 41130314]. References: [1] Zhao Z, et al., 2008a. Acta Petrologica Sinica, 24 (2): 193-202 [2] Zhao Z, et al., 2008b. Geochimica et Cosmochimica Acta, 72, 12 (Supp.): A1095 [3] Zhao Z, et al., 2009. Lithos, 113: 190-212 [4] Liu C-Z, et al., 2011, Geology, 39, 923-926 [5] Liu C-Z, et al., 2014, Geology, Scientific Report, 4, 4232; DOI:10.1038/srep04232

  17. The Behaviors that College Students Classify as Political Bias: Preliminary Findings and Implications

    ERIC Educational Resources Information Center

    Tollini, Craig

    2009-01-01

    There have been a number of recently published books and reports about the existence of a liberal bias in academia (e.g., ACTA 2005, ACTA 2006, Berube 2006, Black 2004, Horowitz 2006, Horowitz 2008, and Shapiro 2004). Sociology is one of the disciplines that is most frequently cited as "producers" of bias in two of these studies (ACTA 2006,…

  18. Guia del Proceso del IFSP de Colorado: Conexiones para la Ninez Temprana, Iniciativa Infantil de Colorado Parte C del Acta de Educacion para Individuos con Desabilidades (Colorado Guidelines for the IFSP Process: Early Childhood Connections, Colorado's Infant/Toddler Initiative for Part C of the Individuals with Disabilities Education Act).

    ERIC Educational Resources Information Center

    Miller, Jerri; Petersen, Sandy

    This booklet for Spanish-speaking parents of young children with disabilities describes Colorado's Individualized Family Service Plan (IFSP) process. It explains guidelines, shares family stories and reflections for families and care providers, and the describes the values that drive the IFSP process in Colorado. Information is provided on…

  19. Comment on "Structural and vibrational studies on 1-(5-Methyl- [1,3,4] thiadiazol-2-yl)-pyrolidin-2-ol" [Spectrochimica Acta Part A, 152 (2016) 252-261]. The importance of intramolecular OH ⋯ N hydrogen bonding in the conformational properties of thiadiazol-pyrrolidin-2-ol bearing species

    NASA Astrophysics Data System (ADS)

    Laurella, Sergio L.; Erben, Mauricio F.

    2016-07-01

    The title paper [1] reports a study on the spectroscopic and physicochemical properties of 1-(5-methyl- [1,3,4]thiadiazol-2-yl)-pyrrolidin-2-ol (MTPN) based on experimental and theoretical data. The latter ones are based on the computed molecular structure for a rather unusual conformer. Here, after a careful analysis of the conformational space of MTPN, the most stable conformation was determined for the molecule isolated in a vacuum, which results to be 21.9 kJ/mol more stable than the conformer reported previously. Our study also includes the closely related species 1-(5-trifluoromethyl- [1,3,4]thiadiazol-2-yl)-pyrrolidin-2-ol (FMTPN). An intramolecular OH ⋯ N hydrogen bond determines the conformational behavior of the [1,3,4]thiadiazol-2-yl)-pyrrolidin-2-ol group as demonstrated by Natural Bond Orbital population analysis.

  20. Comment on "Structural and vibrational studies on 1-(5-Methyl- [1,3,4] thiadiazol-2-yl)-pyrolidin-2-ol" [Spectrochimica Acta Part A, 152 (2016) 252-261]. The importance of intramolecular OH⋯N hydrogen bonding in the conformational properties of thiadiazol-pyrrolidin-2-ol bearing species.

    PubMed

    Laurella, Sergio L; Erben, Mauricio F

    2016-07-05

    The title paper [1] reports a study on the spectroscopic and physicochemical properties of 1-(5-methyl- [1,3,4]thiadiazol-2-yl)-pyrrolidin-2-ol (MTPN) based on experimental and theoretical data. The latter ones are based on the computed molecular structure for a rather unusual conformer. Here, after a careful analysis of the conformational space of MTPN, the most stable conformation was determined for the molecule isolated in a vacuum, which results to be 21.9kJ/mol more stable than the conformer reported previously. Our study also includes the closely related species 1-(5-trifluoromethyl- [1,3,4]thiadiazol-2-yl)-pyrrolidin-2-ol (FMTPN). An intramolecular OH⋯N hydrogen bond determines the conformational behavior of the [1,3,4]thiadiazol-2-yl)-pyrrolidin-2-ol group as demonstrated by Natural Bond Orbital population analysis.

  1. Reply to the comment by Wu et al. (2016) on "Behavior of Re and Os during contact between an aqueous solution and oil: Consequences for the application of the Re-Os geochronometer to petroleum" [Geochim. Cosmochim. Acta 158 (2015) 1-21

    NASA Astrophysics Data System (ADS)

    Reisberg, Laurie; Michels, Raymond; Mahdaoui, Fatima

    2016-08-01

    We reply here to the questions raised by Wu et al. concerning the results published by Mahdaoui et al. (2015). This paper describes experiments in which aqueous solutions containing ReO4- and OsCl62- were brought in contact with natural oils at various ranges of concentration, time and temperature. The main observation is that the transfer of Re and Os to oils is very efficient under all experimental conditions. Wu et al. argue that thermodynamic equilibrium was not achieved in these experiments as apparent partition coefficients are inconsistent. They conclude that the experiments were flawed by possible leaking of reactors and that the conclusions by Mahdaoui et al. (2015) were not justified. In the following reply we explain that Mahdaoui et al. (2015) never claimed that thermodynamic equilibrium was achieved. Any calculations or considerations in this context are therefore meaningless. We recall the objectives of our publication, which were to experimentally test the behavior of ReO4- and OsCl6- (two plausible chemical forms of Re and Os in deep aquifers of petroleum systems) in aqueous solution-oil systems. To our knowledge these are the first experiments of their kind. The parameters that could influence the precision and reproducibility of our results were discussed in detail in Mahdaoui et al. (2015). The essential point is that all 60 of the experiments provide evidence of substantial transfer of Re and Os from water to oil. In contrast to what was mistakenly understood by Wu et al., the paper does not challenge the use of Re-Os to date geological events affecting petroleum. Instead, by providing a mechanism that might allow Os isotopic homogenization on a basin-wide scale, a critical step missing from most current models, it offers a possible explanation of how Re-Os geochronology in oils could potentially work. More generally, our study suggests that transfer of Re and Os from waters to oil may be an important phenomenon that should not be overlooked.

  2. Two new species of the genus Amphilimna (Echinodermata: Ophiuroidea) from southern China

    NASA Astrophysics Data System (ADS)

    Liao, Yulin

    1989-12-01

    Two new species of the ophiuriod genus Amphilimna from 280 m depth water east of Hainan Island are described. A. sinica sp. nov. shows affinities with A. transacta (Koehler), and A. granulosa is related to A. cribriformis A. M. Clark.

  3. Taiwan Earthquake Damage Index Sin Mei Nga* and Masataka Andob a* Department of Geology, Chinese Culture University, No. 55, Hwa-Kang Road, Yang-Ming-Shan, Taipei 11114, Taiwan b Institute of Earth Sciences, Academia Sinica, 128, Sec2, Academia Road, Nangang, Taipei 11529, Taiwan * Corresponding author. Tel.: +886 (02) 28 61 05 11 ext.26133 fax: +886 (02) 28 61 49 59 E-mail: wsw2@ulive.pccu.edu.tw or sin_mei_josephine_ng@hotmail.com

    NASA Astrophysics Data System (ADS)

    Ng, S.

    2012-12-01

    Taking advantage of a previous study and twelve-year, free-field strong motion data in Taiwan, a preliminary, five-level earthquake damage index is newly proposed: I-No (no damage), II-Very Light, III-Light, IV-Moderate, and V-Heavy. For index I, PGA and PGV are, respectively, <62.5 gal and <11 cm/s. Likewise, for index II, PGA is ≧62.5 and ≦187.5 gal; but, PGV is ≧11 and ≦35 cm/s. Similarly, PGA is ≧187.5 and ≦325 gal; but, PGV is ≧35 and ≦55 cm/s for index III. The corresponding PGA and PGV, for index IV, are ≧325 and ≦450 gal and ≧55 and ≦75 cm/s. Finally, for index V, PGA and PGV are respectively >450 gal and >75 cm/s. Ten damaging seismic events in the past twelve years are redefined using this new earthquake damage index, with the devastating Chi-Chi earthquake and one non-damaging event as reference earthquakes. This newly proposed index depicts seismic hazard of these earthquakes with higher accuracy when compared to the existing intensity scale in Taiwan region. For further analysis, Japan earthquakes are also plotted as references.

  4. Actin isoform specificity is required for the maintenance of lactation

    PubMed Central

    Weymouth, Nate; Shi, Zengdun; Rockey, Don C.

    2014-01-01

    Smooth muscle α-actin (Acta2) is one of six highly conserved mammalian actin isoforms that appear to exhibit functional redundancy. Nonetheless, we have postulated a specific functional role for the smooth muscle specific isoform. Here, we show that Acta2 deficient mice have a remarkable mammary phenotype such that dams lacking Acta2 are unable to nurse their offspring effectively. The phenotype was rescued in cross fostering experiments with wild type mice, excluding a developmental defect in Acta2 null pups. The mechanism for the underlying phenotype is due to myoepithelial dysfunction postpartum resulting in precocious involution. Further, we demonstrate a specific defect in myoepithelial cell contractility in Acta2 null mammary glands, despite normal expression of cytoplasmic actins. We conclude that Acta2 specifically mediates myoepithelial cell contraction during lactation and that this actin isoform therefore exhibits functional specificity. PMID:22123032

  5. Toxicity of nine insecticides on four natural enemies of Spodoptera exigua.

    PubMed

    Liu, Yongqiang; Li, Xiangying; Zhou, Chao; Liu, Feng; Mu, Wei

    2016-12-13

    Spodoptera exigua, which feeds on various crops worldwide, has natural enemies that are susceptible to the insecticides used against S. exigua. We investigate the toxicity and residue risk of 9 insecticides on the development of H. axyridis, C. sinica, S. manilae and T. remus. S. manilae and T. remus adults were sensitive to all 9 insecticides (LC50 less than 2.75 mg a.i. liter(-1)), while H. axyridis and C. sinica adults were less sensitive (LC50 between 6 × 10(-5) mg a.i. liter(-1) and 78.95 mg a.i. liter(-1)). Emamectin benzoate, spinosad, indoxacarb, alpha-cypermethrin, chlorfenapyr and chlorantraniliprole showed no toxicity on H. axyridis, C. sinica, S. manilae and T. remus pupae with the recommended field concentrations. The risk analysis indicated that chlorantraniliprole is harmless to larvae of four natural enemies and adult of H. axyridis, C. sinica and S. manilae. Emamectin benzoate and spinosad had higher safety to the development of H. axyridis, C. sinica, S. manilae and T. remus with the risk duration less than 4d. Indoxacarb, tebufenozide, chlorfenapyr, methomyl, alpha-cypermethrin and chlorpyrifos showed dangerously toxic and long risk duration on S. manilae and T. remus adults.

  6. Toxicity of nine insecticides on four natural enemies of Spodoptera exigua

    PubMed Central

    Liu, Yongqiang; Li, Xiangying; Zhou, Chao; Liu, Feng; Mu, Wei

    2016-01-01

    Spodoptera exigua, which feeds on various crops worldwide, has natural enemies that are susceptible to the insecticides used against S. exigua. We investigate the toxicity and residue risk of 9 insecticides on the development of H. axyridis, C. sinica, S. manilae and T. remus. S. manilae and T. remus adults were sensitive to all 9 insecticides (LC50 less than 2.75 mg a.i. liter−1), while H. axyridis and C. sinica adults were less sensitive (LC50 between 6 × 10−5 mg a.i. liter−1 and 78.95 mg a.i. liter−1). Emamectin benzoate, spinosad, indoxacarb, alpha-cypermethrin, chlorfenapyr and chlorantraniliprole showed no toxicity on H. axyridis, C. sinica, S. manilae and T. remus pupae with the recommended field concentrations. The risk analysis indicated that chlorantraniliprole is harmless to larvae of four natural enemies and adult of H. axyridis, C. sinica and S. manilae. Emamectin benzoate and spinosad had higher safety to the development of H. axyridis, C. sinica, S. manilae and T. remus with the risk duration less than 4d. Indoxacarb, tebufenozide, chlorfenapyr, methomyl, alpha-cypermethrin and chlorpyrifos showed dangerously toxic and long risk duration on S. manilae and T. remus adults. PMID:27958333

  7. Resonance Scattering Analysis by Autoregressive Models Applied to Air-Filled, Cylindrical, Thin Walled Shells in Water

    DTIC Science & Technology

    1997-10-01

    plane wave by a circular cylindrical shell. Results of computations. Acustica - Acta Acustica , 82, 1996: 689-697. [5] de Billy M., Determination of the...circumferential waves on cylindrical elastic shells. Acustica - Acta Acustica , 82, 1996: 707-716. [14] Bhattacharyya G.K., and Johnson R.A., Statistical...22] Batard H, Talmant M., and Quentin G.J., The Acoustical Characteristics Estimation Method (MECA) applied to cylinders and shells. Acta Acustica

  8. Outdoor Sound Propagation Modelling in Complex Environments: Recent Developments in the Parabolic Equation Method

    DTIC Science & Technology

    2006-10-01

    equation for sound waves in inhomogeneous moving media”, Acustica united with Acta Acustica , Vol 83(3), pp 455-460,1997. [3] L. Dallois, Ph. Blanc...propagation in a turbulent atmosphere within the parabolic approximation”, Acustica united with Acta Acustica , Vol 87(1), pp 659-669, 2001 [6] M. Karweit...approaches", Acta Acustica united with Acustica , 89 (6), 980-991, (2003). [40] Ph. Voisin, Ph. Blanc-Benon, "The influence of meteorological

  9. Spatial Hearing in Echoic Environments

    DTIC Science & Technology

    2008-02-29

    target from masker and thereby support selective attention. (Published in 2005 in Acta Acustica united with Acustica [J3]) A paper was published...localization. (Published in 2008 in Acta Acustica united with Acustica [J10]) Interest in the perceptual consequences of reverberation on perception...E Larson and Satyavarta (2005). “Top-down and bottom-up influences on spatial unmasking,” Acta Acustica united with Acustica . [J4] Naka, Y, A

  10. Creativity and Democratic Governance. Adult Learning: A Strategic Choice. Proceedings of the ICAE World Assembly (6th, Ocho Rios, Jamaica, August 9-12, 2001) = Creativite et Gouvernance Democratique. L'apprentissage des Adultes: Un Choix Strategique. Actes de la Assemblee Mondiale du CIEA (6th, Ocho Rios, Jamaique, 9 au 12 aout 2001) = Creatividad y Gobernabilidad Democratica. Educacion de Adultos: Una Eleccion Estrategica. Actas de la Asamblea Mundial del ICAE (6th, Ocho Rios, Jamaica, Agosto 9-12, 2001).

    ERIC Educational Resources Information Center

    Dobson, Stephan, Ed.

    This document contains information from and about a world assembly on creativity and democratic governance in adult learning that was held by the International Council for Adult Education (ICAE) and its partner organizations in the Caribbean. The proceedings begin with English, French, and Spanish translations of the address…

  11. The Genesis of tectonically and hydrothermally controlled industry mineral deposits: A geochemical and structural study

    NASA Astrophysics Data System (ADS)

    Wölfler, Anke; Prochaska, Walter; Henjes-Kunst, Friedhelm; Fritz, Harald

    2010-05-01

    surfaces was proposed by Sandrone & Zucchetti, 1988. Magnesite and talc bearing shearzones in ultramafic hostrocks (Lahnaslampi & Horsmanaho, Finland): Both deposits are situated in the Proterozoic schist belt where the talc-magnesite rocks at Lahnaslampi are associated with minor serpentine breccias. The steatitization took place in two different stages: During prograde metamorphism with H2O-dominated solutions and at declining temperature and pressure in the presence of CO2-bearing fluids that resulted in the main steatitization along tectonic structures. A combined geological, petrological and geochronological is chosen to resolve mechanism of mineralisation within the different tectonic setting. Different phases of mineral formation are first distinguished by pertrological and structural field work and then dated by radiometric techniques. Fluid species and chemical environment during mineralisation is resolved by geochemical techniques and stable isotope studies. References Grillo, S., Prochaska, W. (2007): Fluid Chemistry and Stable Isotope Evidence of Shearzone related Talc and Chlorite Mineralizations in Central Sardinia-Italy, In: Conference Abstracts SGA-Meeting. Radvanec, M., Koděra, P., Prochaska, W. (2004): Mg replacement of the Gemerska Poloma talk-magnesite deposit, Western Carpathians, Slovakia. Acta Petrologica Sinica, 20, 773-790. Sandrone, Zucchetti (1988): Geology of the Italian high-quality cosmetic talc from the Pinerolo district (Western Alps). Zuffar' Days - Symposium held in Cagliari, 10-15

  12. Multi-stage barites in partially melted UHP eclogite: implications for fluid/melt activities during deep continental subduction in the Sulu orogenic belt

    NASA Astrophysics Data System (ADS)

    Wang, Songjie; Wang, Lu

    2015-04-01

    . Zr-in-rutile thermometry shows their formation temperature to be 586-664 oC at 1.5-2.5 GPa. Barite-bearing MS inclusions with Ba-bearing K-feldspar (type-II) connected by Kfs+Pl+Bt veinlets of in-situ phengite breakdown and thin barite veinlets along grain boundaries (type-III) are products of phengite breakdown and induced fluid flow during exhumation. These barites have witnessed the gradational separation process of melt/ fluid from miscibility on/above the second critical endpoint during UHP metamorphism, to immiscibility along the exhumation path of the subducted slab. Associated reactions from pyrite to hematite and goethite with the type-III barite ring surrounding the pyrite provide evidence for a local high oxygen fugacity environment during eclogite partial melting and subsequent melt/fluid crystallization processes. Moreover, large grain barite aggregations (type-IV) modified by amphibole+albite symplectite are most likely formed by release of molecular and hydroxyl water from anhydrous minerals of eclogite during high-grade amphibolite-facies retrogression. The growth of multi-stage barites in UHP eclogite further advances our understanding of fluid/melt transfer, crystallization processes along the subduction-exhumation path of the partially melted eclogite, broadening our knowledge of melt/fluid evolution within subduction-collision zones worldwide. REFERENCES Chen Y.X., et al., 2014, Lithos, 200, 1-21. Liu J.B., et al., 2000, Acta Petrologica Sinica 16(4), 482-484. Zeng L.S., et al., 2007, Chinese Science Bulletin, 52(21), 2995-3001. Gao X.Y., et al., 2012, Journal of Metamorphic Geology, 30(2), 193-212.

  13. Advances in membrane protein crystallography: in situ and in meso data collection

    SciTech Connect

    Weyand, Simone; Tate, Christopher G.

    2015-05-23

    Membrane protein structural biology has made tremendous advances over the last decade but there are still many challenges associated with crystallization, data collection and structure determination. Two independent groups, Axford et al. [(2015), Acta Cryst. D71, 1228–1237] and Huang et al. [(2015), Acta Cryst. D71, 1238–1256], have published methods that make a major contribution to addressing these challenges.

  14. Interactions and Binding Energies of Dimethyl Methylphosphonate and Dimethyl Chlorophosphate with Amorphous Silica

    DTIC Science & Technology

    2012-07-10

    Phys. 2007, 127, 184708. (17) Palmero, A.; Aldao, C. M. Readsorption and Diffusion-Limited TPD of Water from Zeolite Linde 4A. Thermochim. Acta 1998...319, 177−184. (18) Palmero, A.; Loffler, D. G. Kinetics of Water Desorption from Pelletized 4A and 5A Zeolites . Thermochim. Acta 1990, 159, 171−176

  15. Wave Propagation in Granular Media Including Marine Sediments

    DTIC Science & Technology

    2002-09-30

    the latter were present at all). Our preliminary findings have been reported in papers published in Acta Acustica , the Journal of Computational...underwater acoustics experiments”, Acta Acustica , in press. 19. M. J. Buckingham, E. M. Giddens, J. B. Pompa, F. Simonet and T. R. Hahn, “A light

  16. Auditory and Cross-Modal Spatial Attention

    DTIC Science & Technology

    2007-01-01

    interaural level and interaural envelope timing (weak cues for left-right direction). This work, published in Acustica united with Acta Acustica in... Acta Acust united Acustica 2005; 91:967-9. Durlach NI, Mason CR, Gallun FJ, Shinn-Cunningham BG, Colburn HS, and Kidd G Jr. Informational masking for

  17. Emergence of the Green’s Functions from Noise and Passive Acoustic Remote Sensing of Ocean Dynamics

    DTIC Science & Technology

    2010-09-30

    environments, Acta Acustica united with Acustica , 95, no. 6, p. 963–974 (2009b) [published, refereed] O. A. Godin, Emergence of deterministic Green’s...Godin, Emergence of acoustic Green’s functions from time averages of ambient noise, Acta Acustica united with Acustica (2010) [in press, refereed

  18. Real Time Urban Acoustics Using Commerical Technologies

    DTIC Science & Technology

    2011-08-01

    situations with a non-refracting atmosphere: Model based on analytical solutions for diffraction and reflection. Acustica — Acta Acustica 1997;83:436...by hard sound barriers and seamounts.’ [20] E. Salomons, 1997 ACTA ACUSTICA , 83, 436-454, ’Sound propagation in complex outdoor situations with a

  19. Leading the Charge: Governors, Higher Education and Accountability

    ERIC Educational Resources Information Center

    American Council of Trustees and Alumni, 2014

    2014-01-01

    With this new tool, ACTA [American Council of Trustees and Alumni] is working to expand its outreach to governors nationwide on behalf of higher education reform, focusing on key issues of quality, cost, and accountability. ACTA has worked with governors and education leaders from across the country, and that experience has proven that innovative…

  20. USSR Report, Life Sciences Biomedical and Behavioral Sciences.

    DTIC Science & Technology

    2007-11-02

    Pharmacological College, Niigata, Japan [Abstract] Following research that described Rickettsia rickettsii and R. prowazekii, using an electron...of Mice Fibroblasts Infected With Rickettsia Tsutsugamushi (T. Tsuruhara, et al.; ACTA VIROLOGICA, No 6, Nov 82) 13 Some Clinical...Russian, 13 Western. [230-12131] SURFACE MORPHOLOGY OF MICE FIBROBIASTS INFECTED WITH RICKETTSIA TSUTSUGAMUSHI Bratislava’ACTA VIROLOGICA in Russian

  1. The Vanishing Shakespeare: A Report by the American Council of Trustees and Alumni

    ERIC Educational Resources Information Center

    Neal, Anne D.; Mitchell, Charles

    2007-01-01

    As this report goes to press, the nation's capital is in the midst of a six-moth, city-wide celebration of William Shakespeare. With this celebration as a backdrop, the American Council of Trustees and Alumni (ACTA) researched how Shakespeare fits into English curricula at 70 of the nation's leading colleges and universities. ACTA surveyed English…

  2. The Effect of an Experimental Missile Wound to the Brain on Brain Electrolytes, Regional Cerebral Blood Flow and Blood Brain Barrier Permeability.

    DTIC Science & Technology

    1987-02-10

    13:59-64, 1980 @@ - -.q e SO86 17. Anden N-E, Dahlstrom A, Fuxe K, et al: Functional role of the nigro-striatal dopamine neurons. Acta Pharmac Tox 24...Acta Physiol Scand Suppl 367:69-93, 1971 19. Anden N-E: Effect of amphetamine and some other drugs on central catecholamine mechanisms, in Costa E

  3. Science and Technology Policy in the People's Republic of China: Organizational Structures and Processes.

    ERIC Educational Resources Information Center

    Handberg, Roger; Xinming, Liu

    In the People's Republic of China, science and technology policy is directed by the state and is an all encompassing managerial system through which courses of action are determined. The Chinese Academy of Sciences (Academia Sinica), a national comprehensive research center was established in 1949 to train qualified scientists and technicians. The…

  4. Bibliography of Chinese Materials on Tai Linguistics.

    ERIC Educational Resources Information Center

    Boltz, William G.

    This bibliography is an effort to establish a convenient listing of works in Chinese which deal with any of the various aspects of Tai linguistics. There are 50 entries including cross-references. Some of the sources covered are: Academia Sinica, Bulletin of the Institute of History and Philology, Institute of History and Philology, Yu-yen…

  5. A novel denitrifying methanotroph of the NC10 phylum and its microcolony.

    PubMed

    He, Zhanfei; Cai, Chaoyang; Wang, Jiaqi; Xu, Xinhua; Zheng, Ping; Jetten, Mike S M; Hu, Baolan

    2016-09-01

    The NC10 phylum is a candidate phylum of prokaryotes and is considered important in biogeochemical cycles and evolutionary history. NC10 members are as-yet-uncultured and are difficult to enrich, and our knowledge regarding this phylum is largely limited to the first species 'Candidatus Methylomirabilis oxyfera' (M. oxyfera). Here, we enriched NC10 members from paddy soil and obtained a novel species of the NC10 phylum that mediates the anaerobic oxidation of methane (AOM) coupled to nitrite reduction. By comparing the new 16S rRNA gene sequences with those already in the database, this new species was found to be widely distributed in various habitats in China. Therefore, we tentatively named it 'Candidatus Methylomirabilis sinica' (M. sinica). Cells of M. sinica are roughly coccus-shaped (0.7-1.2 μm), distinct from M. oxyfera (rod-shaped; 0.25-0.5 × 0.8-1.1 μm). Notably, microscopic inspections revealed that M. sinica grew in honeycomb-shaped microcolonies, which was the first discovery of microcolony of the NC10 phylum. This finding opens the possibility to isolate NC10 members using microcolony-dependent isolation strategies.

  6. Extended Abstracts. The Electrochemical Society Fall Meeting (174th) Held in Chicago, Illinois on 9-14 October 1988. Volume 88-2

    DTIC Science & Technology

    1988-10-14

    sealed under moderate vacuum with Bunsen J. Ortega and J. Herrero flame. The sealed tube was annealed at Instituto Energias Renovables . CIEMAT 400*C for...B.Shao.Y.Wu and J.WanaAcracurrent Iph , the readout of the same Iph when Energiae Solaris Sinica,No.4,35: (19S6).light was chopped off manually and the total

  7. JPRS Report, Science & Technology China

    DTIC Science & Technology

    1989-02-23

    are albinos , probably due to their long-term culture history (1 and 1/2 years). References 1. Chen Ying, et al., SCIENTIA SINICA, Vol 1, 1974 pp... TEA C02 laser; 17 -- Beam spreading telescope; 18,26 ~ He-Ne laser; 23 — Slit; 25 — Step motor controlled reflecting mirror; 27 — Bolometer or

  8. JPRS Report, Science & Technology, China

    DTIC Science & Technology

    2007-11-02

    Cultures of Lyme Disease Spirochetes ( Borrelia burgdorferi ) [Wan Kanglin, Zhang Jinsheng, et aL.; ZHONGHUA LIUXINGBINGXUE ZAZHI, No 5, Oct 91] ......... 12...Spirochetes ( Borrelia SINICAE] in Chinese Vol 13 No 5, Oct 91 pp 332-337 burgdorferi ) [English abstract of article by Tian Jide [3944 1323 40091004H

  9. Journal of the Chinese Silicate Society (Selected Articles).

    DTIC Science & Technology

    2014-09-26

    Diameter Sapphire Crystals in Tubular and Rod Shapes;, by Zhang Shouqing, Tang Lianan, Wang Wen, and Le Xiuhong ................................ 1...Jingwen....... ......................................... 21 ’< .. .L7- THE EFG GROWTH AND APPLICATION OF SMALL DIAMETER SAPPHIRE CRYSTALS • LIN TUBULAR AND...ROD SHAPES Zhang Shouqing, Tang Lianan, Wang Wen, Le Xiuhong (Shanghai Institute of Ceramics, Academia Sinica) Small diameter sapphire crystals in

  10. The crucial role of Activin A on the formation of primordial germ cell-like cells from skin-derived stem cells in vitro.

    PubMed

    Sun, Rui; Sun, Yuan-Chao; Ge, Wei; Tan, Hui; Cheng, Shun-Feng; Yin, Shen; Sun, Xiao-Feng; Li, Lan; Dyce, Paul; Li, Julang; Yang, Xiao; Shi, Qing-Hua; Shen, Wei

    2015-01-01

    Primordial germ cells (PGCs) are founder cells of the germ cell lineage, and can be differentiated from stem cells in an induced system in vitro. However, the induction conditions need to be optimized in order to improve the differentiation efficiency. Activin A (ActA) is a member of the TGF-β super family and plays an important role in oogenesis and folliculogenesis. In the present study, we found that ActA promoted PGC-like cells (PGCLCs) formation from mouse skin-derived stem cells (SDSCs) in both embryoid body-like structure (EBLS) differentiation and the co-culture stage in a dose dependent manner. ActA treatment (100 ng/ml) during EBLS differentiation stage and further co-cultured for 6 days without ActA significantly increased PGCLCs from 53.2% to 82.8%, and as well as EBLS differentiation without ActA followed by co-cultured with 100 ng/ml ActA for 4 to 12 days with the percentage of PGCLCs increasing markedly in vitro. Moreover, mice treated with ActA at 100 ng/kg body weight from embryonic day (E) 5.5-12.5 led to more PGCs formation. However, the stimulating effects of ActA were interrupted by Smad3 RNAi, and in an in vitro cultured Smad3(-/-) mouse skin cells scenario. SMAD3 is thus likely a key effecter molecule in the ActA signaling pathway. In addition, we found that the expression of some epiblast cell markers, Fgf5, Dnmt3a, Dnmt3b and Wnt3, was increased in EBLSs cultured for 4 days or PGCLCs co-cultured for 12 days with ActA treatment. Interestingly, at 16 days of differentiation, the percentage of PGCLCs was decreased in the presence of ActA, but the expression of meiosis-relative genes, such as Stra8, Dmc1, Sycp3 and Sycp1, was increased. In conclusion, our data here demonstrated that ActA can promote PGCLC formation from SDSCs in vitro, at early stages of differentiation, and affect meiotic initiation of PGCLCs in later stages.

  11. Solid Electrolytes: Alkali-Ion Transport in Skeleton Structures

    DTIC Science & Technology

    1975-12-31

    Hagman and P. Kierkegaard , Acta Chem. Scand. 2_2, 1822 (1968). R.G. Sizova, A.A. Voronkov. N.G. Shomyatskaga. V.V. Pynkhin and N V Belov...Subsequently it was w learned that Hagman and Kierkegaard (6) had reported the structure of NaZr2P3012. With the same space group, they...Dokl. Akad. Nauk SSSR. Ser. 205, Issue 1. 90 (1972). 5 H.Y-P. Hong, Acta. Cryst. B30, 468 (1974). 6. L. Hagman and P. Kierkegaard , Acta. Chem

  12. Prediction of Molecular Properties.

    DTIC Science & Technology

    1987-08-01

    21. Cobbledick, R.E. and Small, R.W.H., Acta Cryst, Vol. B30, p. 1918, 1974. 22. Filhol, A., Bravic, G., Rey-Lafon, M., and Thomas , M., Acta Cryst...Mortimer, C.T., Quincey , P.G., and Springall, H.D., J Chem Soc, p. 958, 1958. 27. Captain Michael Coolidge was of great assisstance in completing the...Bravic, G., Rey-Lafon, M.. and Thomas , M., Acta Cryst, Vol. B36, p. 575, 1980. 205/206 APPENDIX B The following file is the VAX DCL command file that

  13. Between the laboratory and the deep blue sea: space issues in the marine stations of Naples and Wimereux.

    PubMed

    de Bont, Raf

    2009-04-01

    In the 1870s, the life sciences witnessed the rise of a new site for scientific research: the marine station. This new workplace brought the laboratory of the biologist closer to the natural surroundings of the marine organisms that he/she was studying. It was therefore a site where the lab could be 'renaturalized'. In this paper, the extent of this 'renaturalization' is studied with regard to two stations. The first, Anton Dohrn's Stazione zoologica in Naples, was to become an international centre for laboratory research, while the second, Alfred Giard's marine station in Wimereux (France), turned out to be an important hub for field studies. Field-oriented animal life studies could be developed in Wimereux, whereas these were largely outshone by physiological and morphological research in Naples. I argue that differences in the physical and social organization of the two stations - or their 'ecologies' - accounted for the varying practices and types of knowledge found in Naples and Wimereux.

  14. Invertebrate neuroscience and CephsInAction at the Mediterranean Society for Neuroscience Meeting Cagliari 2015.

    PubMed

    Holden-Dye, Lindy; Fiorito, Graziano; Ponte, Giovanna

    2015-12-01

    Invertebrate neuroscience, and in particular cephalopod research, is well represented in the Mediterranean region. Therefore, the recent meeting of the Mediterranean Society for Neuroscience in Santa Margherita di Pula, Sardinia (12-15 June 2015) provided an excellent opportunity for invertebrate contributions. Furthermore, the Chair of an EU COST Action for cephalopod research (FA1301; www.cephsinaction.org ), Giovanna Ponte, together with Graziano Fiorito from the Stazione Zoologica, Naples, aligned a meeting of research groups working in the field of cephalopod neurophysiology from across Europe to coincide with the neuroscience meeting. This provided an exciting forum for exchange of ideas. Here we provide brief highlights of both events and an explanation of the activities of the COST Action for the broader invertebrate neuroscience community.

  15. Five scientists on excursion — a picture of marine biology on Helgoland before 1892

    NASA Astrophysics Data System (ADS)

    Zissler, D.

    1995-03-01

    Five scientists on excursion — a picture of marine biology on Helgoland before 1892. The picture, of which several variant poses with minor differences exist, is a photograph taken on Helgoland in September, 1865. The original is to be found in the collections of the Ernst-Haeckel-Haus in Jena. The photograph shows only a few objects and fewer persons, but they are arranged like a bouquet: in front, collecting vessels; behind, grouped around a table, five scientists, Dohrn, Greeff, Haeckel, Salverda, Marchi. They hold up their catching nets like insignia, identifying their basic activity. This photograph is a unique document for the marine biological research on Helgoland before 1892. Furthermore, it illustrates a time and place for the birth of the idea of establishing the world's most famous marine biological station, the Stazione Zoologica di Napoli.

  16. Genetics Home Reference: familial thoracic aortic aneurysm and dissection

    MedlinePlus

    ... the arteries to maintain their shape instead of stretching out as blood is pumped through them. ACTA2 ... the sarcomeres' ability to prevent the arteries from stretching. The aorta, where the force of blood pumped ...

  17. Genetics Home Reference: myosin storage myopathy

    MedlinePlus

    ... proteins accumulate in type I skeletal muscle fibers, forming the protein clumps characteristic of the disorder. It ... Epub 2007 Mar 2. Citation on PubMed Tajsharghi H, Oldfors A. Myosinopathies: pathology and mechanisms. Acta Neuropathol. ...

  18. Genetics Home Reference: Bowen-Conradi syndrome

    MedlinePlus

    ... protein that is involved in the production of cellular structures called ribosomes , which process the cell's genetic instructions ... 8. Citation on PubMed Sondalle SB, Baserga SJ. Human diseases of the SSU processome. Biochim Biophys Acta. ...

  19. Bedside calculation of hemodynamic parameters with a hand held programmable calculator. Part II: Programs for hemodynamic and oxygen transport parameters computation.

    PubMed

    Laurent, M

    1980-01-01

    Two programs calculating oxygen transport parameters and hemodynamic values respectively are described. They may be used indifferently with HP 67 or HP 97 Hewlett Packard calculators. (Acta anaesth. belg., 1980, 31, 53-59).

  20. Genetics Home Reference: hyperphosphatemic familial tumoral calcinosis

    MedlinePlus

    ... regulation of phosphate levels within the body (phosphate homeostasis). Among its many functions, phosphate plays a critical ... of O-glycosylation in the maintenance of phosphate homeostasis. Biochim Biophys Acta. 2009 Sep;1792(9):847- ...

  1. Genetics Home Reference: Miller-Dieker syndrome

    MedlinePlus

    ... Pizzardi G, Del Balzo F, Iannetti P. Neuronal migration disorders: clinical, neuroradiologic and genetics aspects. Acta Paediatr. ... A. 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for ...

  2. USING BIOMONITORING DATA TO INFORM EXPOSURE ASSESSMENT IN CHILDREN

    EPA Science Inventory

    Discussing the challenges associated with estimating and interpreting toxicant exposures and health risks from biomonitoring data. Extended abstract will also be translated in Spanish and published in Acta Toxicologica Argentina.

  3. VISIÓN GENERAL DE LA EVALUACIÓN DEL RIESGO EN SALUD INFANTIL EMPLEANDO UN ENFOQUE POR ETAPAS DE DESARROLLO (American translation is: Overview of a Life Stage Approach to Children's Health Risk Assessment)

    EPA Science Inventory

    Discussing the challenges associated with estimating and interpreting toxicant exposures and health risks from biomonitoring data. This extended abstract was translated in Spanish and published in Acta Toxicologica Argentina.

  4. Uso de los Datos de Biomonitoreo para Informar sobre la Evaluacion Infantil (American translation is: USING BIOMONITORING DATA TO INFORM EXPOSURE ASSESSMENT IN CHILDREN)

    EPA Science Inventory

    Discussing the challenges associated with estimating and interpreting toxicant exposures and health risks from biomonitoring data. This extended abstract was translated in Spanish and published in Acta Toxicologica Argentina.

  5. Genetics Home Reference: aspartylglucosaminuria

    MedlinePlus

    ... This Page Aronson NN Jr. Aspartylglycosaminuria: biochemistry and molecular biology. Biochim Biophys Acta. 1999 Oct 8;1455(2-3):139-54. Review. Citation on PubMed Arvio MA, ... L. Molecular pathogenesis of a disease: structural consequences of aspartylglucosaminuria ...

  6. 76 FR 6683 - Information Related to Risks and Benefits of Powdered Gloves; Request for Comments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-07

    ..., 2003. 2. Malinger, G., S. Ginath, L. Zeidel, et al., ``Starch Peritonitis Outbreak After Introduction of a New Brand of Starch Powdered Latex Gloves,'' Acta Obstetricia et Gynecologica Scandinavica,...

  7. 2-D and 3-D Digital Analysis of Breast Calcifications: A Technique to Improve Mammographic Specificity

    DTIC Science & Technology

    2001-06-01

    the Institute of Laboratory Resources, national Research Council (NIH Publication No. 86-23, Revised 1985). X For the protection of human subjects...193-200, 1983. 23 Sigfusson BF, Andersson I, Aspegren K, et al. Clustered breast calcifications. Acta Radiologica 24: 273-281, 1983. September 19...the breast. Clin Radiol 34:193-200, 1983. 23. Sigfusson BF, Andersson I, Aspegren K, et al. Clustered breast calcifications. Acta Radiologica 24: 273

  8. Cellular and Tissue Injury During Nonfreezing Cold Injury and Frostbite

    DTIC Science & Technology

    1993-09-30

    membranes and is believed to interact primarily with the bulk solvent properties of water on a colligative basis. PVPs, due to their high molecular weights...phase transitions on the selective permeability properties of liposomes. Biochim. Biophys. Acta 406, 423-433 (1975). I 8. Bowers, Jr., W.D., Hubbard...The effects of chain length and lipid phase tiansitions on the selective permeability properties of 3 liposomes. Biochim. Biophys. Acta 406: 187-196. I

  9. A Method for the Analysis of Tabun in Multisol Using Gas Chromatographic Flame Photometric Detection

    DTIC Science & Technology

    2006-05-01

    ethoxy-phosphoryl cyanide (Tabun), Acta Chim.Scand. 1953; 7: 306-314. 12. Holmstedt B. Synthesis and pharmacology of dimethylamido-ethoxy-phosphoryl... cyanide (Tabun). Acta Chim. Scand. 1951, Suppl. No. 90, Stockholm, half-lives taken from figure 2, p 35. 13. Desire B, Saint-Andre, S...Anticonvulsant treatment of nerve agent seizures: anticholinergics vs diazepam in soman- intoxicated guinea pigs. Epilepsy Research 2000; 38: 1-14. 19

  10. Triazolam - Performance Side Effects: Vestibular, Musculoskeletal, and Complex Performance Tests.

    DTIC Science & Technology

    1987-03-04

    nitrazepam 5 mg with triazolam 0.5 mg in young psychiatric insomniac inpatients. Acta Psychiatrica Scandinavica, 62:519-524. 9. Borbely A. A., Loepfe...Kullingsjo H. 1982. Comparison of nitrazepam with triazolam in insomniac out-patients. Acta Psychiatrica Scandinavica, 65:86-92. 17. Damos D. L. 1985. The...1981. Triazolam compared with nitrazepam and with oxazepam in insomnia: Two double-blind crossover studies analyzed sequentially. British Journal of

  11. Activin A accelerates the progression of fetal oocytes throughout meiosis and early oogenesis in the mouse.

    PubMed

    Liang, Gui-Jin; Zhang, Xi-Feng; Wang, Jun-Jie; Sun, Yuan-Chao; Sun, Xiao-Feng; Cheng, Shun-Feng; Li, Lan; De Felici, Massimo; Shen, Wei

    2015-10-15

    Activins can exert several roles in ovary development. However, little is known about their involvement in early mammalian oogenesis. In this study, we reported that activin receptors (including ActRIA, ActRIB, ActRIIA, and ActRIIB) are expressed throughout the development of the mouse ovaries from 12.5 days postcoitum (dpc) to 21 days postparturition (dpp). Moreover, we found that in vitro, the addition of activin A (ActA) to the culture medium of 12.5 dpc ovarian tissues accelerated the progression of oocytes throughout meiotic prophase I stages. This result was reproduced in vivo following administration of ActA to pregnant mice. The in vitro effect of ActA was associated with increased expression of premeiotic and meiotic genes (including Dazl, Spo11, Stra8, Scp3, and Rec8) in the ovarian tissues. Mechanistically, ActA-dependent SMAD3 signaling modulated the expression of members of the retinoic acid (RA) system, including the RA degradation CYP26B1 enzyme and the RA receptors. Finally, ActA promoted the survival and growth of fetal and early postnatal oocytes and primordial follicle assembly both in vitro and in vivo. In conclusion, the present study identifies new roles of ActA in early oogenesis and suggested that ActA and RA might cooperate in promoting meiosis in female germ cells.

  12. On Chinese earthquake history - An attempt to model an incomplete data set by point process analysis

    USGS Publications Warehouse

    Lee, W.H.K.; Brillinger, D.R.

    1979-01-01

    Since the 1950s, the Academia Sinica in Peking, People's Republic of China, has carried out extensive research on the Chinese earthquake history. With a historical record dating back some 3000 years, a wealth of information on Chinese earthquakes exists. Despite this monumental undertaking by the Academia Sinica, much work is still necessary to correct the existing earthquake data for historical changes in population, customs, modes of communication, and dynasties. In this paper we report on the status of our investigation of Chinese earthquake history and present some preliminary results. By applying point process analysis of earthquakes in 'Central China', we found suggestions of (1) lower earthquake activity at intervals of about 175 years and 375 years, and (2) higher earthquake activity at an interval of about 300 years. ?? 1979 Birkha??user Verlag.

  13. Paleozoic exhumation history of the North Qinling terrane,China

    NASA Astrophysics Data System (ADS)

    Dong, Yunpeng; Genser, Johann; Neubauer, Franz; Liu, Xiaoming; Yang, Zhao; Zhang, Guowei; Heberer, Bianca

    2010-05-01

    Ar ages below ca. 300°C at about 367.2 ± 3.0 Ma ~329.5 ± 0.45 Ma. The ages are used to construct a cooling path with slow/non-exhumation during 517~445 Ma, a time-integrated cooling at a rate < 2.5°C/Ma during the 445 - 411Ma period, an acceleration of cooling and exhumation at a cooling rate of 6°C/Ma from 411 Ma to 367 Ma, and subsequently slow/non-cooling from 367 to 330 Ma. The data show a significant delay of exhumation after peak metamorphic conditions and a long period of tectonic quiescence between the Silurian and the Devonian/Carboniferous boundary when the suturing of the Shangdan suture occurred. These relationships exclude classical exhumation models of formation and exhumation of metamorphic cores in orogens, which all imply rapid cooling after peak conditions of metamorphism. References Dong, Y.P., Zhou, M.F., Zhang, G.W., Zhou, D.W., Liu, L., Zhang, Q., 2008. The Grenvillian Songshugou ophiolite in the Qinling Mountains, Central China: Implications for the tectonic evolution of the Qinling orogenic belt. Journal of Asian Earth Sciences, 32: 325-335. Li, S.Z., Kusky, T. M., Wang, L., 2007. Collision leading to multiple-stage large-scale extrusion in the Qinling orogen: Insights from the Mianlue suture. Gondwana Research, 12: 121-143. Meng, Q.R., Zhang, G.W., 1999. Timing of collision of the North and South China blocks: Controversy and reconciliation. Geology, 27:123-126. Zhang, G.W., Zhang, Z.Q., Dong, Y.P., 1995. Nature of Main Tectono-Lithostratigraphic Units of the Qinling Orogen: Implications for the Tectonic Evolution. Acta Petrologica Sinica, 11: 101-114. (In Chinese with English abstract).

  14. A novel denitrifying methanotroph of the NC10 phylum and its microcolony

    PubMed Central

    He, Zhanfei; Cai, Chaoyang; Wang, Jiaqi; Xu, Xinhua; Zheng, Ping; Jetten, Mike S. M.; Hu, Baolan

    2016-01-01

    The NC10 phylum is a candidate phylum of prokaryotes and is considered important in biogeochemical cycles and evolutionary history. NC10 members are as-yet-uncultured and are difficult to enrich, and our knowledge regarding this phylum is largely limited to the first species ‘Candidatus Methylomirabilis oxyfera’ (M. oxyfera). Here, we enriched NC10 members from paddy soil and obtained a novel species of the NC10 phylum that mediates the anaerobic oxidation of methane (AOM) coupled to nitrite reduction. By comparing the new 16S rRNA gene sequences with those already in the database, this new species was found to be widely distributed in various habitats in China. Therefore, we tentatively named it ‘Candidatus Methylomirabilis sinica’ (M. sinica). Cells of M. sinica are roughly coccus-shaped (0.7–1.2 μm), distinct from M. oxyfera (rod-shaped; 0.25–0.5 × 0.8–1.1 μm). Notably, microscopic inspections revealed that M. sinica grew in honeycomb-shaped microcolonies, which was the first discovery of microcolony of the NC10 phylum. This finding opens the possibility to isolate NC10 members using microcolony-dependent isolation strategies. PMID:27582299

  15. A novel denitrifying methanotroph of the NC10 phylum and its microcolony

    NASA Astrophysics Data System (ADS)

    He, Zhanfei; Cai, Chaoyang; Wang, Jiaqi; Xu, Xinhua; Zheng, Ping; Jetten, Mike S. M.; Hu, Baolan

    2016-09-01

    The NC10 phylum is a candidate phylum of prokaryotes and is considered important in biogeochemical cycles and evolutionary history. NC10 members are as-yet-uncultured and are difficult to enrich, and our knowledge regarding this phylum is largely limited to the first species ‘Candidatus Methylomirabilis oxyfera’ (M. oxyfera). Here, we enriched NC10 members from paddy soil and obtained a novel species of the NC10 phylum that mediates the anaerobic oxidation of methane (AOM) coupled to nitrite reduction. By comparing the new 16S rRNA gene sequences with those already in the database, this new species was found to be widely distributed in various habitats in China. Therefore, we tentatively named it ‘Candidatus Methylomirabilis sinica’ (M. sinica). Cells of M. sinica are roughly coccus-shaped (0.7–1.2 μm), distinct from M. oxyfera (rod-shaped; 0.25–0.5 × 0.8–1.1 μm). Notably, microscopic inspections revealed that M. sinica grew in honeycomb-shaped microcolonies, which was the first discovery of microcolony of the NC10 phylum. This finding opens the possibility to isolate NC10 members using microcolony-dependent isolation strategies.

  16. Smooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-β

    PubMed Central

    Papke, Christina L.; Cao, Jiumei; Kwartler, Callie S.; Villamizar, Carlos; Byanova, Katerina L.; Lim, Soon-Mi; Sreenivasappa, Harini; Fischer, Grant; Pham, John; Rees, Meredith; Wang, Miranda; Chaponnier, Christine; Gabbiani, Giulio; Khakoo, Aarif Y.; Chandra, Joya; Trache, Andreea; Zimmer, Warren; Milewicz, Dianna M.

    2013-01-01

    Mutations in ACTA2, encoding the smooth muscle cell (SMC)-specific isoform of α-actin (α-SMA), cause thoracic aortic aneurysms and dissections and occlusive vascular diseases, including early onset coronary artery disease and stroke. We have shown that occlusive arterial lesions in patients with heterozygous ACTA2 missense mutations show increased numbers of medial or neointimal SMCs. The contribution of SMC hyperplasia to these vascular diseases and the pathways responsible for linking disruption of α-SMA filaments to hyperplasia are unknown. Here, we show that the loss of Acta2 in mice recapitulates the SMC hyperplasia observed in ACTA2 mutant SMCs and determine the cellular pathways responsible for SMC hyperplasia. Acta2−/− mice showed increased neointimal formation following vascular injury in vivo, and SMCs explanted from these mice demonstrated increased proliferation and migration. Loss of α-SMA induced hyperplasia through focal adhesion (FA) rearrangement, FA kinase activation, re-localization of p53 from the nucleus to the cytoplasm and increased expression and ligand-independent activation of platelet-derived growth factor receptor beta (Pdgfr-β). Disruption of α-SMA in wild-type SMCs also induced similar cellular changes. Imatinib mesylate inhibited Pdgfr-β activation and Acta2−/− SMC proliferation in vitro and neointimal formation with vascular injury in vivo. Loss of α-SMA leads to SMC hyperplasia in vivo and in vitro through a mechanism involving FAK, p53 and Pdgfr-β, supporting the hypothesis that SMC hyperplasia contributes to occlusive lesions in patients with ACTA2 missense mutations. PMID:23591991

  17. Smooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-β.

    PubMed

    Papke, Christina L; Cao, Jiumei; Kwartler, Callie S; Villamizar, Carlos; Byanova, Katerina L; Lim, Soon-Mi; Sreenivasappa, Harini; Fischer, Grant; Pham, John; Rees, Meredith; Wang, Miranda; Chaponnier, Christine; Gabbiani, Giulio; Khakoo, Aarif Y; Chandra, Joya; Trache, Andreea; Zimmer, Warren; Milewicz, Dianna M

    2013-08-01

    Mutations in ACTA2, encoding the smooth muscle cell (SMC)-specific isoform of α-actin (α-SMA), cause thoracic aortic aneurysms and dissections and occlusive vascular diseases, including early onset coronary artery disease and stroke. We have shown that occlusive arterial lesions in patients with heterozygous ACTA2 missense mutations show increased numbers of medial or neointimal SMCs. The contribution of SMC hyperplasia to these vascular diseases and the pathways responsible for linking disruption of α-SMA filaments to hyperplasia are unknown. Here, we show that the loss of Acta2 in mice recapitulates the SMC hyperplasia observed in ACTA2 mutant SMCs and determine the cellular pathways responsible for SMC hyperplasia. Acta2(-/-) mice showed increased neointimal formation following vascular injury in vivo, and SMCs explanted from these mice demonstrated increased proliferation and migration. Loss of α-SMA induced hyperplasia through focal adhesion (FA) rearrangement, FA kinase activation, re-localization of p53 from the nucleus to the cytoplasm and increased expression and ligand-independent activation of platelet-derived growth factor receptor beta (Pdgfr-β). Disruption of α-SMA in wild-type SMCs also induced similar cellular changes. Imatinib mesylate inhibited Pdgfr-β activation and Acta2(-/-) SMC proliferation in vitro and neointimal formation with vascular injury in vivo. Loss of α-SMA leads to SMC hyperplasia in vivo and in vitro through a mechanism involving FAK, p53 and Pdgfr-β, supporting the hypothesis that SMC hyperplasia contributes to occlusive lesions in patients with ACTA2 missense mutations.

  18. Origin and characterization of alpha smooth muscle actin-positive cells during murine lung development.

    PubMed

    Moiseenko, Alena; Kheirollahi, Vahid; Chao, Cho-Ming; Ahmadvand, Negah; Quantius, Jennifer; Wilhelm, Jochen; Herold, Susanne; Ahlbrecht, Katrin; Morty, Rory E; Rizvanov, Albert A; Minoo, Parviz; El Agha, Elie; Bellusci, Saverio

    2017-04-03

    ACTA2 expression identifies pulmonary airway and vascular smooth muscle cells (SMCs) as well as alveolar myofibroblasts (MYF). Mesenchymal progenitors expressing fibroblast growth factor 10 (Fgf10), Wilms tumor 1 (Wt1), or glioma-associated oncogene 1 (Gli1) contribute to SMC formation from early stages of lung development. However, their respective contribution and specificity to the SMC and/or alveolar MYF lineages remain controversial. In addition, the contribution of mesenchymal cells undergoing active WNT signaling remains unknown. Using Fgf10(CreERT2) , Wt1(CreERT2) , Gli1(CreERT2) , and Axin2(CreERT2) inducible driver lines in combination with a tdTomato(flox) reporter line, the respective differentiation of each pool of labeled progenitor cells along the SMC and alveolar MYF lineages was quantified. The results revealed that while FGF10(+) and WT1(+) cells show a minor contribution to the SMC lineage, GLI1(+) and AXIN2(+) cells significantly contribute to both the SMC and alveolar MYF lineages, but with limited specificity. Lineage tracing using the Acta2-CreERT2 transgenic line showed that ACTA2(+) cells labeled at embryonic day (E)11.5 do not expand significantly to give rise to new SMCs at E18.5. However, ACTA2(+) cells labeled at E15.5 give rise to the majority (85%-97%) of the SMCs in the lung at E18.5 as well as alveolar MYF progenitors in the lung parenchyma. Fluorescence-activated cell sorting-based isolation of different subpopulations of ACTA2(+) lineage-traced cells followed by gene arrays, identified transcriptomic signatures for alveolar MYF progenitors versus airway and vascular SMCs at E18.5. Our results establish a new transcriptional landscape for further experiments addressing the function of signaling pathways in the formation of different subpopulations of ACTA2(+) cells. Stem Cells 2017.

  19. Modulating myosin restores muscle function in a mouse model of nemaline myopathy

    PubMed Central

    Lindqvist, Johan; Levy, Yotam; Pati‐Alam, Alisha; Hardeman, Edna C.; Gregorevic, Paul

    2016-01-01

    Objective Nemaline myopathy, one of the most common congenital myopathies, is associated with mutations in various genes including ACTA1. This disease is also characterized by various forms/degrees of muscle weakness, with most cases being severe and resulting in death in infancy. Recent findings have provided valuable insight into the underlying pathophysiological mechanisms. Mutations in ACTA1 directly disrupt binding interactions between actin and myosin, and consequently the intrinsic force‐generating capacity of muscle fibers. ACTA1 mutations are also associated with variations in myofiber size, the mechanisms of which have been unclear. In the present study, we sought to test the hypotheses that the compromised functional and morphological attributes of skeletal muscles bearing ACTA1 mutations (1) would be directly due to the inefficient actomyosin complex and (2) could be restored by manipulating myosin expression. Methods We used a knockin mouse model expressing the ACTA1 His40Tyr actin mutation found in human patients. We then performed in vivo intramuscular injections of recombinant adeno‐associated viral vectors harboring a myosin transgene known to facilitate muscle contraction. Results We observed that in the presence of the transgene, the intrinsic force‐generating capacity was restored and myofiber size was normal. Interpretation This demonstrates a direct link between disrupted attachment of myosin molecules to actin monomers and muscle fiber atrophy. These data also suggest that further therapeutic interventions should primarily target myosin dysfunction to alleviate the pathology of ACTA1‐related nemaline myopathy. Ann Neurol 2016;79:717–725 PMID:26891371

  20. Pseudopolymorphism in hydroxybenzophenones: the dihydrate of 2,2',4,4'-tetrahydroxybenzophenone.

    PubMed

    Landre, I M R; Martins, F T; Ellena, J A; Dos Santos, M H; Doriguetto, A C

    2012-04-01

    A dihydrate pseudopolymorph of bis(2,4-dihydroxyphenyl)methanone, C(13)H(10)O(5)·2H(2)O, (I), was obtained during polymorphism screening of hydroxybenzophenone derivatives. This structure, in which the molecule sits on a twofold axis, was compared with the known anhydrous form of (I) [Schlemper (1982). Acta Cryst. B38, 554-559]. The role of water in the crystal assembly was established on the basis of the known monohydrate pseudopolymorph of 3,4-dihydroxybenzophenone [Landre, Souza, Corrêa, Martins & Doriguetto (2010). Acta Cryst. C66, o463-o465].

  1. Multiscale Modeling and Process Optimization for Engineered Microstructural Complexity

    DTIC Science & Technology

    2007-10-26

    2005. 25. R. T. Brewer , D. A. Boyd, M. Y. El-Naggar, S. W. Boland, Y.-B. Park, S. M. Haile, D. G. Goodwin, and H. A. Atwater, Growth of biaxially...Zhang and K. Bhattacharya. A computational model of ferroelectric domains. Part II: Grain boundaries and defect pinning. Acta Materialia 53: 199...electromechanical actuation Acta Materialia, 51, 5941-5960, 2003. 37. R.T. Brewer , H.A. Atwater, J.R. Groves and P.N. Arendt Reflection high-energy electron

  2. Integration of Statistical and Physical Models of Short Fatigue Crack Growth.

    DTIC Science & Technology

    1987-02-01

    M.R. James and B.N. Cox, *Fundamental Characterization of Surface Microplasticity ," Final Report on NSF Grant No. DMR-8310652, July 1986. 23. W.L...Dec. 1985. 24. W.L. Morris, B.N. Cox and M.R. James, " Microplastic Deformation of Al 2219- T85 I," to be published in Acta Metall. 25. B.N. Cox, W.L...Morris and M.R. James, "Two-Stage Microplastic Surface Defor- mation in Al 2219-T851," to be published in Acta Metall. 26. W.L. Morris, M.R. James and

  3. A Novel Approach to Regeneration of Bone: Using Focused Ultrasound for the Spatiotemporal Patterning of Angiogenic and Osteogenic Factors

    DTIC Science & Technology

    2012-04-01

    FM, Ruíz-Hernández, E, Boré, A, Arcos , D, Vallet-Regí, M and Vilaboa, N . Acta Biomater 6:12, 4522-31 (2010) 10 APPENDICES 1.) Abstract submitted...Martín-Saavedra FM, Ruíz-Hernández E, Boré A, Arcos D, Vallet-Regí M, and Vilaboa N . Acta Biomater 6, 2010, pp.4522-31. 5. Kruse DE, Mackanos MA...unstimulated controls. Data are means + standard deviation for n = 3. We have characterized the kinetics of activation and re-inducibility of 10T1/2

  4. Temperature Regulation during Upper Body Exercise: Able Bodied and Spinal Cord Injured

    DTIC Science & Technology

    1989-04-01

    REFERENCES 1. Asmussen. E. and M . Nielsen. The regulation of the body temperature during work performed with the arms and with the legs. Acta Physiol. Scand...14:373-382. 1947. 2. Astrand. I. Aerobic work capacity in men and women. Acta Physiol. Scand. 49: (Suppl. 169)64-73, 1960. 3. Attia, M . and P. Engel...9:225-228. 1984. 10. Downey. J.A.. H.P. Chiodi and R.C. Darling. Central temperature regulation in the spinal man. J. AppI. Physiol. 22:91-94. 1967

  5. An In Vivo Selection Identifies Listeria monocytogenes Genes Required to Sense the Intracellular Environment and Activate Virulence Factor Expression

    PubMed Central

    Portnoy, Daniel A.

    2016-01-01

    Listeria monocytogenes is an environmental saprophyte and facultative intracellular bacterial pathogen with a well-defined life-cycle that involves escape from a phagosome, rapid cytosolic growth, and ActA-dependent cell-to-cell spread, all of which are dependent on the master transcriptional regulator PrfA. The environmental cues that lead to temporal and spatial control of L. monocytogenes virulence gene expression are poorly understood. In this study, we took advantage of the robust up-regulation of ActA that occurs intracellularly and expressed Cre recombinase from the actA promoter and 5’ untranslated region in a strain in which loxP sites flanked essential genes, so that activation of actA led to bacterial death. Upon screening for transposon mutants that survived intracellularly, six genes were identified as necessary for ActA expression. Strikingly, most of the genes, including gshF, spxA1, yjbH, and ohrA, are predicted to play important roles in bacterial redox regulation. The mutants identified in the genetic selection fell into three broad categories: (1) those that failed to reach the cytosolic compartment; (2) mutants that entered the cytosol, but failed to activate the master virulence regulator PrfA; and (3) mutants that entered the cytosol and activated transcription of actA, but failed to synthesize it. The identification of mutants defective in vacuolar escape suggests that up-regulation of ActA occurs in the host cytosol and not the vacuole. Moreover, these results provide evidence for two non-redundant cytosolic cues; the first results in allosteric activation of PrfA via increased glutathione levels and transcriptional activation of actA while the second results in translational activation of actA and requires yjbH. Although the precise host cues have not yet been identified, we suggest that intracellular redox stress occurs as a consequence of both host and pathogen remodeling their metabolism upon infection. PMID:27414028

  6. Scientometric Analysis of the Journals of the Academy of Medical Sciences in Bosnia and Herzegovina

    PubMed Central

    Masic, Izet; Begic, Edin; Zunic, Lejla

    2016-01-01

    Introduction: Currently in Bosnia and Herzegovina there are 25 journals in the field of biomedicine, 6 of them are indexed in Medline/PubMed base (Medical Archives, Materia Socio-Medica, Acta Informatica Medica, Acta Medica Academica, Bosnian Journal of Basic Medical Sciences (BJBMS) and Medical Glasnik), and one (BJBMS) is indexed in Science Citation Index Expanded (SCIE)/Web of Science base. Aim: The aim of this study was to show the scope of work of the journals that were published by Academy of Medical Sciences of Bosnia and Herzegovina - Medical Archives, Materia Socio-Medica and Acta Informatica Medica. Material and Methods: The research presents a meta-analysis of three journals, or their issues, during the calendar year 2015 (retrospective and descriptive character). Results: During 2015 calendar year a total of 286 articles were published (in Medical Archives 104 (36.3%), in Materia Socio-Medica 99 (34.6%), and in Acta Informatica Medica 83 (29%)). Original articles are present in the highest number in all three journals (in Medical Archives 80.7%, in Materia Socio Medica 77.7%, and in Acta Informatica Medica 68.6%). In Medical Archives, 90.3% of the articles were related to the field of clinical medicine. In Materia Socio-Medica, the domain of clinical medicine and public health was the most represented. Preclinical areas are most frequent in Acta Informatica Medica. The period of 50-60 days for a decision on the admission of article is most common in all three journals, with trend of shortening of that period. Articles came from 19 countries, mostly from Bosnia and Herzegovina, then from Iran, Kosovo, Saudi Arabia and Greece. Conclusion: In Medical Archives original articles in the field of clinical medicine (usually internal and surgical disciplines) are most often present, and that is the case in last four years. The number of articles in Materia Socio-Medica and Acta Informatica Medica is growing from year to year. In Materia Socio-Medica there is a

  7. UF Biomotor/Biosensor Nanotechnologies

    DTIC Science & Technology

    2007-09-25

    beads by taking the product of the volume of stock beads and surface area of one bead by the volume of one bead (0.338 m2 for 50 IiL of 5.63% (v/v) stock...BSA) divided by the circumference of the Stokes radius of ActA (6.3 nm for ActA and 3.5 nm for BSA). The product of bead area and protein mass/area...data not shown). To address this issue, we first noted that DHLA QDs coated with maltose binding protein (MBP) did not aggregate in the cytoplasm of

  8. Time Dependent Fluid Occurrence Offshore Taiwan

    NASA Astrophysics Data System (ADS)

    Chen, L.

    2010-12-01

    Time Dependent Fluid Occurrence Offshore Taiwan Liwen Chenab, Wu-Cheng Chia, Char-Shine Liuc (mma@earth.sinica.edu.tw)(wchi@gate.sinica.edu.tw) ; aInstitute of Earth Sciences, Academia Sinica, Taipei, Taiwan bInstitute of Geosciences, National Taiwan University, Taipei, Taiwan ; cInstitute of Oceanography, National Taiwan University, Taipei, Taiwan Earthquake-induced groundwater flows have been observed recently. Such fluid flow might temporarily change the temperature field in the crust. Here we used seismically detected gas hydrate under seafloor to study the temperature fields at a few hundred meters subbottom depth before, and after the 2006 Henchuan earthquake (Mw7.0). We used the hydrate-related bottom-simulating-reflector (BSR) in seismic profiles to study the effects of gas/fluid migration on the BSR attributes. We have conducted two seismic experiments before and after the earthquake across the same transects near the hypocenter of the earthquake using similar air gun arrays and streamers. By analyzing this unique dataset, we found enhanced BSR reflectivity in average after the earthquake (~0.03), but the Sea-floor reflectivity is very similar (~0.5). We also found changed amplitudes versus offset (AVO) in the dataset (the gradient of reflection coefficient versus the angles was ~-0.34). We interpret these results as a consequence of earthquake-induced gas and fluid migration, bringing the gases underneath the BSR, thus the enhanced reflection coefficients. Next we will explore new methods to use the BSR as a flow meter. Using time-dependent seismic attribute analyses across transects before and after a large earthquake, we found strong evidences of earthquake-related fluid migrations and possibly associated temperature perturbations. This is among the first studies to document such feature in the offshore region.

  9. Genetic diversity of Ephedra plants in mongolia inferred from internal transcribed spacer sequence of nuclear ribosomal DNA.

    PubMed

    Kitani, Yuki; Zhu, Shu; Batkhuu, Javzan; Sanchir, Chinbat; Komatsu, Katsuko

    2011-01-01

    Ephedrae herba has been used for treating colds, relieving coughs and asthma from ancient times. We previously reported the distribution of Ephedra sinica, E. equisetina, E. przewalskii, E. regeliana, E. monosperma and Ephedra sp. in Mongolia, and among them E. sinica and E. equisetina were potential new resources of Ephedrae herba of Japanese pharmacopoeia grade, based on our field survey and subsequent molecular and chemical assessments. However, the Ephedra population in southwestern areas showed a high possibility of having hybrid origins. Further field surveys in southwestern areas, and sequence analysis of the partial nuclear internal transcribed spacer 1 (ITS1) region, besides trnK and 18S ribosomal RNA (rRNA) gene regions, were conducted in order to obtain detailed evidence of hybridization status. As a result, the distribution of E. glauca in western area and E. lomatolepis in western-most area was confirmed. The ITS sequences from all 8 Ephedra species collected in Mongolia were roughly divided into 5 types (types I-V). Type II sequence, having several additive nucleotides, was found in Ephedra sp., E. glauca, E. regeliana and E. sinica, which provided useful information for tracing hybrid origins. Morphological, genetic and distribution evidence suggested that the hybridization of Ephedra species occurred widely in southwestern Mongolia, and several Ephedra species including E. przewalkskii and E. intermedia were involved in these events. Integrated with our previous report, trnK-, 18S- and ITS-types from pure lines of each species are proposed. In addition, we propose a practicable method for detecting additive peaks on a direct sequencing electropherogram.

  10. [Analysis of the preferred conformations and determination of the concentrations of ephedrine and pseudoephedrine based on hollow fiber liquid-phase microextraction].

    PubMed

    Chen, Xuan; Bai, Xiaohong; Wang, Xiao; Wang, Jing; Bu, Wei

    2010-12-01

    The preferred conformations of the ephedrine and pseudoephedrine in Ephedra sinica Stapf and rat urine were analyzed by the hollow fiber liquid-phase microextraction (HF-LPME) and their extraction mechanisms were illuminated. The method of the separation of the ephedrine and pseudoephedrine and the determination of their concentrations with high performance liquid chromatography (HPLC) were established. The optimal experimental conditions were as follows: the organic phase carrier was the hollow fiber of polyvinylidene fluoride (MOF-503), organic solvent was n-hexanol, the extraction time was 35 min, the stirring rate was 1200 r/min, the sample phase was the NaOH solution (5 mol/L) of the analyte, the acceptor was 0.01 mol/L H2SO4 solution. The extracts were analyzed by HPLC. Under the optimal conditions, the method is convenient and highly sensitive. In Ephedra sinica Stapf, the linear ranges of ephedrine and pseudoephedrine were 5-100 microg/L, the detection limits were 1.9 microg/L and 1.2 microg/L and the enrichment factors were 38 and 61, respectively. The average recoveries of ephedrine and pseudoephedrine were 100.6% +/- 1.2% and 103.2% +/- 3.5%, respectively. In rat urine, their linear ranges were 100 - 5 x 10(4) microg/L, the detection limits were 30 microg/L and 42 microg/L and the enrichment factors were 20 and 17, respectively. In rat urine, their average recoveries were 108.4% +/- 4.4% and 106. 1% +/- 5.4%, respectively. The obtained results indicated that the method can be successfully applied for the extraction and determination of the ephedrine and pseudoephedrine in Ephedra sinica Stapf and rat urine.

  11. Study on the EGG masses of 12 species of cypraeidae

    NASA Astrophysics Data System (ADS)

    Qi, Zhongyan; Ma, Xiutong

    1988-06-01

    Researchers of the Institute of Oceanology, Academia Sinica, collected 46 species and subspecies of Cypraeidae during their 1955 1978 surveys on the marine mollusks along the coasts of Guangdong, Guangxi and Hainan Provinces and Xisha (Paracels) Islands in the South China Sea. Twelve species belonging to 7 genera with their egg masses were collected mainly from the intertidal zone where the animals were laying their eggs. The collection dates of each of the species and a preliminary description of their egg masses are given in this paper.

  12. Silicon Based Mid Infrared SiGeSn Heterostructure Emitters and Detectors

    DTIC Science & Technology

    2016-05-16

    subsequently implemented this structure on a GeSn p-i-n photodiode. Following the deposition of a gold thin film, the nanoholes are milled using a focused...Tsai at Academia Sinica. The beam currents and accelerating voltages are 40 pA and 30 keV, respectively. The target diameter and period of nanoholes ...comparison. One as is (control sample) without any metal on top, another with gold film but no pattern, the third with the gold film with 2D nanohole

  13. The Greenland Telescope: antenna retrofit status and future plans

    NASA Astrophysics Data System (ADS)

    Raffin, Philippe; Ho, Paul T. P.; Asada, Keiichi; Blundell, Raymond; Bower, Geoffrey C.; Burgos, Roberto; Chang, Chih-Cheng; Chen, Ming-Tang; Christensen, Robert; Chu, You-Hua; Grimes, Paul K.; Han, C. C.; Huang, Chih-Wei L.; Huang, Yau-De; Hsieh, Fang-Chia; Inoue, Makoto; Koch, Patrick M.; Kubo, Derek; Leiker, Steve; Lin, Lupin; Liu, Ching-Tang; Lo, Shih-Hsiang; Martin-Cocher, Pierre; Matsushita, Satoki; Nakamura, Masanori; Meyer-Zhao, Zheng; Nishioka, Hiroaki; Norton, Tim; Nystrom, George; Paine, Scott N.; Patel, Nimesh A.; Pu, Hung-Yi; Snow, William; Sridharan, T. K.; Srinivasan, Ranjani; Wang, Jackie

    2016-07-01

    Since the ALMA North America Prototype Antenna was awarded to the Smithsonian Astrophysical Observatory (SAO), SAO and the Academia Sinica Institute of Astronomy and Astrophysics (ASIAA) are working jointly to relocate the antenna to Greenland. This paper shows the status of the antenna retrofit and the work carried out after the recommissioning and subsequent disassembly of the antenna at the VLA has taken place. The next coming months will see the start of the antenna reassembly at Thule Air Base. These activities are expected to last until the fall of 2017 when commissioning should take place. In parallel, design, fabrication and testing of the last components are taking place in Taiwan.

  14. Achievements in Chinese Traditional Medical Treatment of Schistosomiasis and Malaria - Communist China

    DTIC Science & Technology

    2007-11-02

    Afcademia Sinica, the resalts of syst^J.^^fp^ention and show that pumpkin seed taken orally " effective^in the^pr ev n treateent of exper^entaa sc "jg...34™^ S d^^re was 95-77^ three grams of pumpkan seed orally daily ior o J parasites, it raised the ^f ^^f^^^Äics Departoent of the fell and the...the drug from three to seven days. , „, ,. ,_. * (c) Ch’ien-chin-tzu and Hsiao-shui Pills: Ch’xen chxn-tzu is the seed of a plant of the family

  15. Control and monitoring software for the Greenland Telescope

    NASA Astrophysics Data System (ADS)

    Patel, Nimesh A.; Nishioka, Hiroaki; Huang, Chih-Wei Locutus

    2016-08-01

    The Greenland Telescope (GLT) is a 12m diameter antenna that is being developed from the ALMA North America prototype antenna, for VLBI observations and single-dish science approaching THz, at the Summit station in Greenland. The GLT is a collaboration between the Smithsonian Astrophysical Observatory and the Academia Sinica Institute of Astronomy and Astrophysics. We describe the control and monitoring software that is being developed for GLT. The present version of the software is ready for the initial tests of the antenna at Thule, including optical and radio pointing calibration, holography, and VLBI observations at 230 GHz.

  16. Highland macrolichen flora of Northwestern Yunnan, China.

    PubMed

    Hur, Jae-Seoun; Wang, Li-Song; Oh, Soon-Ok; Kim, Gyoung Hee; Lim, Kwang-Mi; Jung, Jae-Sung; Koh, Young Jin

    2005-06-01

    Fifty-six species in 36 genera of macrolichens are reported from the Zhongdian area, northwest Yunnan, China during the lichenological expedition for highland macrolichen survey in June, 2004. More than 60% of these species have not been reported in South Korea. All of the 182 collected specimens are deposited in the Korean Lichen Research Institute (KoLRI) at Sunchon National University in Korea, and some of them are duplicated in the lichen herbarium, Crytogamic Herbarium, Kunming Institute of Botany, Academia Sinica (KUN-L) in China. This is the first report on the macrolichen flora in the visited areas.

  17. Biological effects of carbon ions with medium energy on plant seeds

    SciTech Connect

    Zengquan Wei; Yuyan Liu; Guiling Wang; Xuebing Chen; Huiling Li; Hanmin Yang; Lihong Wang; Qingxiang Gao; Chongying Wang; Yafu Wang

    1995-03-01

    The biological effects of 46.6 MeV/u {sup 12}C{sup 6+} ions on four kinds of plant seeds were studied at the Heavy Ion Research Facility in Lanzhou (HIRFL), Institute of Modern Physics (IMP), Academia Sinica. The results show that germination of the seeds is inhibited by exposure to ions. In root tip cells of irradiated seeds, a great variety of chromosomal aberrations were observed. Sensitivities in terms of inhibition of germination and induction of chromosomal aberrations in the four species are correlated. 7 refs., 1 fig., 1 tab.

  18. Total Phenolic Contents and Antioxidant Capacities of Selected Chinese Medicinal Plants

    PubMed Central

    Song, Feng-Lin; Gan, Ren-You; Zhang, Yuan; Xiao, Qin; Kuang, Lei; Li, Hua-Bin

    2010-01-01

    Antioxidant capacities of 56 selected Chinese medicinal plants were evaluated using the Trolox equivalent antioxidant capacity (TEAC) and ferric reducing antioxidant power (FRAP) assays, and their total phenolic content was measured by the Folin-Ciocalteu method. The strong correlation between TEAC value and FRAP value suggested that the antioxidants in these plants possess free radical scavenging activity and oxidant reducing power, and the high positive correlation between antioxidant capacities and total phenolic content implied that phenolic compounds are a major contributor to the antioxidant activity of these plants. The results showed that Dioscorea bulbifera, Eriobotrya japonica, Tussilago farfara and Ephedra sinica could be potential rich sources of natural antioxidants. PMID:20640157

  19. Laser Journal (Selected Articles),

    DTIC Science & Technology

    1982-09-10

    OPTICAL PROPERTIES OF SINGLE CRYSTAL SULPHONATED SALICYLIC ACID Wang Gongming, Jiang Xiengmei) Wang Wencheng (Physics Department, Fudan University) A...laser is described. The apparatus structure and some experimental results are reported. MATERIAL AND ELEMENT MAGNETO-OPTIC PROPERTIES OF Pr dYb),(1oAI...Sinica) The 9,,.d of (BiPzGdyb0,(F!AI 1, single crystal thin film at 6328A is as high as 3.69-4.05’/dB . This property has been applied to optical

  20. ZOONET: perspectives on the evolution of animal form. Meeting report.

    PubMed

    Fischer, Antje H L; Arboleda, Enrique; Egger, Bernhard; Hilbrant, Maarten; McGregor, Alistair P; Cole, Alison G; Daley, Allison C

    2009-11-15

    What drives evolution? This was one of the main questions raised at the final ZOONET meeting in Budapest, Hungary, in November 2008. The meeting marked the conclusion of ZOONET, an EU-funded Marie-Curie Research Training Network comprising nine research groups from all over Europe (Max Telford, University College London; Michael Akam, University of Cambridge; Detlev Arendt, EMBL Heidelberg; Maria Ina Arnone, Stazione Zoologica Anton Dohrn Napoli; Michalis Averof, IMBB Heraklion; Graham Budd, Uppsala University; Richard Copley, University of Oxford; Wim Damen, University of Cologne; Ernst Wimmer, University of Göttingen). ZOONET meetings and practical courses held during the past four years provided researchers from diverse backgrounds--bioinformatics, phylogenetics, embryology, palaeontology, and developmental and molecular biology--the opportunity to discuss their work under a common umbrella of evolutionary developmental biology (Evo Devo). The Budapest meeting emphasized in-depth discussions of the key concepts defining Evo Devo, and bringing together ZOONET researchers with external speakers who were invited to present their views on the evolution of animal form. The discussion sessions addressed four main topics: the driving forces of evolution, segmentation, fossils and phylogeny, and the future of Evo Devo.

  1. Antibodies to Liposomal, Phosphatidylcholine and Phosphatidylsulfocholine

    DTIC Science & Technology

    1990-01-01

    Biochim. Biophys. tidylcholine have also been induced by immuniz- Acta, 689: 319-326. ing mice with bromelain -treated mouse erythrocytes (Cox BISSERET, P...with lysolecithin and sphingomyelin, thus bromelain -modified RBC are specifically inhibited by a common indicating specificity for the phosphocholine

  2. Effects of space flights on human allergic status (IgE-mediated sensitivity)

    NASA Astrophysics Data System (ADS)

    Buravkova, L. B.; Rykova, M. P.; Gertsik, Y. G.; Antropova, E. N.

    2007-02-01

    Suppression of the immune system after space flights of different duration has been reported earlier by Konstantinova [Immune system in extreme conditions, Space immunology. B. 59. M. Science 1988. 289p. (in Russian) [4]; Immunoresistance of man in space flight, Acta Astronautica 23 (1991) 123-127 [5

  3. Upper Airway Sequelae in Burn Patients Requiring Endotracheal Intubation or Tracheostomy

    DTIC Science & Technology

    1985-03-01

    airways. In adult patients, our experi - It was remarkable that autopsy findings in 12 patients ence is that as long as the nasotracheal tube is not...tracheostomy. Acta Anaesthesiol TB et al., eds. Progress in Anaesthesiology : Proceedings of the Scand 1979; 23:57-68. Fourth World Congress of

  4. Passive Dynamics in the Control of Gymnastic Maneuvers.

    DTIC Science & Technology

    1995-03-01

    that must be satis ed for the moon to exhibit stable librational motion. In 1885, Henri Poincar e [ Poincare ] realized that a linearized analysis could... Poincare ] Poincar e, H. 1885. Sur l’equilibre d’une mass uide. Acta math. VIII, 293-299. [Nigg 74] Nigg, B.M., 1974. Analysis of Twisting and Turning

  5. Prepared in Mind and Resources? A Report on Public Higher Education in South Carolina

    ERIC Educational Resources Information Center

    Alacbay, Armand; Poliakoff, Michael

    2011-01-01

    In 2011, South Carolina Governor Nikki Haley signed into law the South Carolina Higher Education Efficiency and Administrative Policies Act, maintaining the transparency and accountability that lead to increased academic quality and affordability at colleges and universities. It is in this context that ACTA (American Council of Trustees and…

  6. How technology is reshaping the practice of nongynecologic cytology: frontiers of cytology symposium.

    PubMed

    Bibbo, Marluce

    2007-01-01

    To pay tribute to the Founders of Acta Cytologica, this Golden Anniversary symposium on nongynecologic cytology revives the written symposium style of the 1950s. Participants from countries throughout the world were asked how new technologies are currently applied in their laboratories and whether future advances and challenges can be predicted. The specific questions and the participants' answers follow.

  7. 77 FR 63203 - 50th Anniversary of the Office of the United States Trade Representative

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ... Trade Representative By the President of the United States of America A Proclamation On October 11, 1962, President John F. Kennedy signed the Trade Expansion Act--a landmark piece of legislation that established a..., and build a business. NOW, THEREFORE, I, BARACK OBAMA, President of the United States of America,...

  8. A New NDE Capability for Thin-Shelled Structures

    DTIC Science & Technology

    1989-02-03

    package was enclosed with a radiation-shielded sheet-metal housing. This protected the package from ambient light, X-rays, and electro-magnetic...6] Edholm, P.R., Quiding, L., "Elimination of Blur in Linear Tomography," Acta Radiologica , Vol. 10, pp. 441-447, 1970. [71 Strohbehn, J.W., Yates

  9. Follow-Up Care for Older Women With Breast Cancer

    DTIC Science & Technology

    1999-08-01

    Resources, national Research Council (NIH Publication No. 86-23, Revised 1985). •ZFor the protection of human subjects, the investigator(s) adhered to...Cancer: Complications of Axillary Management. Acta Radiologica Oncology. 1986; 25:105-108. 16. Christenson SB and Lundgren E. Sequelae of Axillary

  10. Microstructurally Based Cross-slip Mechanisms and Their Effects on Dislocation Microstructure Evolution in fcc Crystals

    DTIC Science & Technology

    2015-01-01

    nickel microcrystals, Acta Mater. 56 (13) (2008) 2008. [58] G Makov P Landau , R Z Shneck, A. Venkert, Evolution of dislocation patterns in fcc metals, IOP...orientation: I. disloca- tion arrangement and cell structure of crystals deformed in tension, Philos. Mag. 28 (1973) 1057–1976. [61] P. Landau , R.Z. Shneck

  11. Archeological Investigations in the Truscott Reservoir Area. King and Knox Counties, Texas,

    DTIC Science & Technology

    1978-06-01

    Aspectos de Arqueologia e Historic del Noreste, Monterrey, Mexico, April 23-26, 1975. 1976 The Panhandle Archaic. In The Texas Archaic: A Symposium...Texas Panhandle. Actas del 41 Congreso Inter- nacional de Americanistas, Vol. 1, pp. 270-278. Institute Nacional de Antropologia e Historia

  12. On Dynamic Loads in Parallel Shaft Transmissions. 1. Modelling and Analysis.

    DTIC Science & Technology

    1987-08-01

    NASA CR-179473, 1986. 16. Lundberg, G.; and Palmgren , A.: Dynamic Capacity of Rolling Bearings . Acta Polytech. Mech. Eng. Sci., vol. 1, no. 3, 1947...founda- tion (ref. 15). Let qcj be the contribution to q" from the local compliance due to contact stresses. With the procedures o Lundberg and Palmgren

  13. 77 FR 72909 - International Day of Persons With Disabilities, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-06

    ... persons with disabilities through the Americans with Disabilities Act--a sweeping civil rights bill that... the rights of every person does not end at our borders, but extends to every country and every community. It continues for the woman who is at greater risk of abuse because of a disability and for...

  14. Earlier Debridement and Antibiotic Administration Decrease Infection

    DTIC Science & Technology

    2010-01-01

    closure (No Antibiotics) or treatment with tobramycin or vancomycin-impregnated polymethylmethacrylate (PMMA) beads (Antibiotics) and closed. Each time... polymethylmethacrylate beads and hip spacers in vivo. Acta Orthop. 80(2):193– 197, 2009. 10. Gustilo, R. B., Anderson, J. T. Prevention of infection

  15. An Analysis of the Microstructure and Reinforcement Distribution of an Extruded Particle-Reinforced AL 6061-10 Volume Percent Al2O3 Metal Matrix Composite

    DTIC Science & Technology

    1993-09-01

    grain diameter. An upper limit for the grain size, if boundary migration were limited by Zener drag , would obey: D= (34d) / (2 Fv) (S) with variables...Properties, Roskilde, Denmark, 2-6 September 1991. 12. Nes, E., Ryum, N., and Hunderi, 0., "On the Zener Drag ", Acta Metallurgica, Vol. 33, No. 1, p. 22

  16. Synthesis and Structural Characterization of New High-Valent Inorganic Fluorine Compounds and their Oxidizing Properties. Volume 1

    DTIC Science & Technology

    1992-02-01

    G.J. Schrobilgen, unpublished work. 48. A. Zalkin, D.L. Ward, R.N. Biagioni and D.H. Templeton, Inorg. Chem., 1978, 17, 1318. 49. N. Bartlett, B.G...Spcctrochiin. Acta 1960, 10, 505. 25. This work. 26. Zalkin. A., Ward. D.L.; Biagioni , R.N.; Templetoi, DIH.; Bartlett, N. Inorg. Chem. 1978, 17, 1318. 2.7

  17. Dielectric Analysis of Thermoset Cure.

    DTIC Science & Technology

    1985-10-07

    the polymerization of thermosetting polymers, 3. Polyst . Sci., 31, 30S (1959) 58. Warfield, R. V. * Petro*, M. C.: A study of the polymerization of...cure: isothemal curs kinetics, Ihermochimica Acta, 14. 41 (1976) 64. ludd. N. C. W.: Investigation of the polymerization of an unsaturated polyester

  18. Center for Advanced Propulsion Systems

    DTIC Science & Technology

    1993-02-01

    engine also has a Bowditch -type see-through piston. The instrumentation port was used to measure surface temperature from which the instantaneous heat...Analytical Correction for Small Viscous Heating Errors. Rheological Acta. November/December, 28,464-472. Lodge, A., Pritchard, W., and Scott , L. (1991

  19. Emergency Physician Estimation of Blood Loss

    DTIC Science & Technology

    2011-01-01

    between laboratory determination and visual estimation of blood loss during normal delivery. Eur J Obstet Gynecol Reprod Biol. 1991;38:119–124. 3...exaggeration. Acta Obstet Gynecol Scand. 2006;85:1448–1452. 4. Meiser A, Casagranda O, Skipka G, et al. Quantification of blood loss. How precise is visual

  20. Critical Percolation Stresses of Random Frank-Read Sources in Micron-Sized Crystals of Superalloys (Preprint)

    DTIC Science & Technology

    2011-11-01

    tendency for a saturation stress value, most likely because the experimental size-effect data does not include small enough sizes of micron-sized crystals...D, Gumbsch P, Kraft O, Scripta Mater 2008; 58:587. 7) Tang H, Schwarz KW, Espinosa HD, Acta Mater 2007; 55:1607. 8) Zhou C, Biner S, Lesar R

  1. Critical Percolation Stresses of Random Frank-Read Sources in Micrometer-Sized Crystals of Superalloys (Postprint)

    DTIC Science & Technology

    2012-07-09

    controls the yield stress [20]. However, the experimental data [4] do not show any such tendency for a saturation stress value, most likely because the...D M, Parthasarathy T A, Uchic M D, Tang M and Woodward C 2008 Acta Mater. 56 3245 [6] Senger J, Weygand D, Gumbsch P and Kraft O 2008 Scr. Mater. 58

  2. Organization of the Optical Society of America Photonic Science Topical Meeting Series. Volume 3. The Microphysics of Surfaces: Beam-Induced Processes Held in Santa Fe, New Mexico on 11-13 February 1991

    DTIC Science & Technology

    1992-05-22

    as semiconductor material. Impor- tant applications are thin film solar cells, thin film transistors for liquid crystal displays, photoreceptors for...171, 1989. 307-311 3 T.MINAMI, H.NANTO and S.TAKATA, Thin Solid Films, Vol.124, 1985. 43-47 4 D.Z.DA, F.R.ZHU and H.S.TANG, Acta Energiae Solaris

  3. Surface-Bound Biomembranes Incorporating Receptors: Electrochemical and Structural Characterization.

    DTIC Science & Technology

    1991-06-06

    receptnr; (Darszon, 1983; Levitzki , 1985). Here it is used to form planar structures that are potentially more stable and reproducible than the...4, 90-96. Levitzki , A.(1985). Reconstitution of membrane receptor systems. Biochim. Biophys. Acta, 822, 127-153. 16 Heuser, J.E. & Salpeter, S.R

  4. Shallow Water Reverberation and Low Frequency Seabed Scattering

    DTIC Science & Technology

    2012-09-30

    Analytical method of angular power spectrum, range and depth structure of the echo-to-reverberation ratio in shallow water Sound Field,” (Chinese) ACTA ... ACUSTICA , 5 (2), 86-99 (1980). 2. D.R. Jackson and M.D. Richardson, <High-frequency Seafloor Acoustics>, 616 pages, Springer, 2007. 3. J.X. Zhou, X.Z

  5. The Impact of Hearing Protection on Sound Localization and Orienting Behavior

    DTIC Science & Technology

    2005-06-01

    practical implications of the effects of hearing protection devices on ceedings of the Human Factors and Ergonom- localization ability. Acta ...exposure in selection of personal hearing Acustica , 22, 205-213. protection equipment for Chinook aircrews. Aviation, Space, Bolia, R. S., D’Angelo, W

  6. Hazard from an Intense Midrange Impulse

    DTIC Science & Technology

    1989-12-01

    cobaye," Acustica 59, 21-29. 1986), even up to very high sound levels, e.g., the French Hamernik, R. P.. Patterson, J. H., and Salvi. R. J. (1987...Noise on the Cat," Acta -Otolaryngol. Suppl 176, 91 pp. an energy measure at high levels. It is recognized that results MIL-STD 1474(B) (1979). "Noise

  7. Objective Measurement of the Speech Transmission Quality of Vocoders by Means of the Speech Transmission Index

    DTIC Science & Technology

    2005-04-01

    Elberling, C., Keidser, G. and Poulsen, T. (1990). Prediction of intelligibility of non- linearly processed speech. Acta Otolaryngol Suppl., 469, 190-5... Acustica 46, 59-72. [6] Steeneken, H.J.M. (1992) On measuring and predicting speech intelligibility. Soesterberg: TNO Institute for Perception

  8. The U.S. Army Research Laboratory’s Auditory Research for the Dismounted Soldier: Present (2009-2011) and Future

    DTIC Science & Technology

    2012-03-01

    S.; Bronkhorst, A. Auditory Distance Perception in Humans: A Summary of Past and Present Research. Acta Acustica 2005, 91, 409–420. 19...Laboratory. Pollard, K.A., Blumstein, D.T., & Griffin , S.C. (2010). Pre-screening acoustic and other natural signatures for use in noninvasive

  9. AFOSR(Air Force Office of Scientific Research) Chemical and Atmospheric Sciences Program Review (33rd) FY88

    DTIC Science & Technology

    1990-07-01

    and Dimethylnitrosamine", Donald F. McMillen, S. Esther Nigenda, Alicia C. Gonzales, and David M. Golden, Spectrochimica Acta Parta A, Molecular...Computer, and Systems Engineering Boston University Boston, MA 02215 Investigations of the Dynamics and Gonzalo Hernandez Thermodvnamics of the...Polar Regions. PRINCIPAL INVESTIGATOR: Gonzalo Hernandez Research Scientist Space Physics Research Laboratory University of Michigan 2455 Hayward Ann

  10. Analysis of Breast Cell-Lineage Response Differences to Taxol Using a Novel Co-Culture System

    DTIC Science & Technology

    2005-06-01

    oxide ions. These intracellular oxygen-derived free radicals, also called reactive-oxygen intermediates (ROI) accumulate intracellularly, nicking the DNA...immortalization. [Review]. Biochimica et Biophysica Acta, 1991. 1072(1): p. 1-7. 166. Harley , C.B., Telomere loss: mitotic clock or genetic time bomb

  11. Distribution and Characterization of Antigens Found in Subcellular Fractions of African Trypanosomes.

    DTIC Science & Technology

    1979-08-01

    and T. brucei Voorhies et al 1979), with the possible exception of Acanthamoeba custellani (Schultz and Thompson 1969), all demonstrate low...in membrane fragments isolated from Acanthamoeba sp. Biochem. Biophys. Acta 193 203-211. Voorheis, H.P. Gale, J.S., Owen, M.J. and Edwards W. (1979

  12. S&T Efforts for Navy Corrosion Control

    DTIC Science & Technology

    2010-11-01

    compressive surface stress Interstitially carburized layer is referred to as “S-phase” 309SS mag. 100x XRD on 316SS Ref: G. M. Michal, et al., Acta...temperature Inhibits carburization Activation via HCl thins oxide layer and allows carbon diffusion to substrate Corrosion Resistant Surface Treatment

  13. Oral Glycerol Solutions as a Deterrent to Dehydration during Heat Exposure.

    DTIC Science & Technology

    1982-01-01

    Glycerol oxidation in the animal organism Acta Physiol. Scand. 7:69-79. Larsen , Jens Anker . 1963. Elimination of glycerol as a measure of the...Following a single pharmacological oral dose the glycerol is distributed throughout 56 to 85% of the body mass (Shafrir and Gorin 1963, Larsen 1963, Holst

  14. Investigating Multitasking in High-Functioning Adolescents with Autism Spectrum Disorders Using the Virtual Errands Task

    ERIC Educational Resources Information Center

    Rajendran, Gnanathusharan; Law, Anna S.; Logie, Robert H.; van der Meulen, Marian; Fraser, Diane; Corley, Martin

    2011-01-01

    Using a modified version of the Virtual Errands Task (VET; McGeorge et al. in "Presence-Teleop Virtual Environ" 10(4):375-383, 2001), we investigated the executive ability of multitasking in 18 high-functioning adolescents with ASD and 18 typically developing adolescents. The VET requires multitasking (Law et al. in "Acta Psychol" 122(1):27-44,…

  15. Regulatory mimicry in Listeria monocytogenes actin-based motility

    PubMed Central

    Chong, Ryan; Swiss, Rachel; Briones, Gabriel; Stone, Kathryn L.; Gulcicek, Erol E.; Agaisse, Hervé

    2009-01-01

    Summary The actin-based motility of the intracellular pathogen Listeria monocytogenes relies on ActA, a bacterial factor mimicking the activity of host cell nucleation-promoting factors of the WASP/WAVE family. The activity of WASP and WAVE is tightly regulated in cells. However, it is not known whether the activity of ActA is regulated upon L. monocytogenes infection. Here, we used an RNAi-based genetic approach in combination with computer-assisted image analysis to investigate the role of host factors in L. monocytogenes spread from cell to cell. We showed that the host cell serine/threonine kinase CK2 is required for efficient actin tail formation. We demonstrated that, similar to WASP and WAVE, the affinity of ActA for the ARP2/3 complex is regulated by CK2-mediated phosphorylation. We also demonstrated the importance of this regulatory mechanism in a mouse model of infection. Our work suggests that ActA is a bacterial virulence factor that not only displays a structural mimic of the VCA domain of WASP/WAVE family members, but also co-opted CK2 as the host cell factor regulating its activity, a form of mimicry that we refer to as regulatory mimicry. We present comparative evidence supporting the notion that unrelated pathogens displaying actin-based motility may have evolved a similar strategy. PMID:19748468

  16. Stability of Dilute Tabun (GA) Solutions in Various Vehicles

    DTIC Science & Technology

    2007-11-01

    Board for Disarmament, Helsinki, 1977. 2. Larson L. The hydrolysis of dimethylamido-ethoxy-phosphoryl cyanide (Tabun), Acta Chim.Scand. 1953; 7: 306... intoxicated guinea pigs. Epilepsy Research 2000; 38: 1-14. 7. McDonough JH, McMonagle J, Copeland T, Zoeffel D, Shih T-M. A comparative evaluation of

  17. Mechanisms of Retinal Damage from Chronic Laser Radiation.

    DTIC Science & Technology

    1981-07-01

    stopped at the corneal epithelium and at high intensity can cause damage there. The arc welders’ superficial keratitis and the "eyes open sun lamp...John Wiley & Sons Inc., New York, p. 218. 1967. 31. Osterberg, G.: Topography of the layer of rods and cones in the human retina. Acta

  18. Education or Reputation? A Look at America's Top-Ranked Liberal Arts Colleges

    ERIC Educational Resources Information Center

    Poliakoff, Michael; Alacbay, Armand

    2014-01-01

    ACTA [American Council of Trustees and Alumni] today released a report that examines the country's most prestigious liberal arts colleges. Despite endowments soaring as high as $1.8 billion, nearly all institutions increased tuition during the Great Recession to finance bloated administrative spending, with many college presidents enjoying…

  19. SETI-3: the Search for ExtraTerrestrial Intelligence. A selection of papers from 1987-1990 Symposia of the International Academy of Astronautics held during the 38th-41st Congress (Brighton, Bangalore, Malaga, Dresden) of the International Astronautical Federation.

    PubMed

    1992-01-01

    This special issue of Acta Astronautica is a compilation of selected papers presented at Review Meetings on SETI at the 1987-1990 International Academy of Astronautics Congresses. Papers are drawn from seven areas: bioastronomical context, SETI technology, SETI searches, radio frequency interferences, possibilities for newer instrumentation, interdisciplinary connections, and public relations. Two papers presented at the Pesek Lecture are included.

  20. Evaluation of Fuzzy Fiber Sensors for Structural Health Monitoring

    DTIC Science & Technology

    2010-11-01

    as Electrodes”, J. Ceram. Soc. Japan, 102(12); pp. 745-51 (1994). 10. M. Pumera , S. Sanchez, I. Ichinose, and J. Tang, “Electrochemical...Pingarron, Anal. Chim. Acta 622, p. 11, (2008). 16. M. Pumera , S. Sanchez, I. Ichinose, and J. Tang, Sens. Actuators B 123, p. 1195 (2007). 17. K

  1. Amnesia Production by Visual Stimulation.

    DTIC Science & Technology

    1982-12-01

    electroconvulsive shock-produced retro- grade amnesia in the rat. J Comp Physiol Psychol 88:373-377 (1975). 5. Cronholm, B., and L. Molander. Memory...disturbances after electrocon- vulsive therapy : 5. Conditions one month after a series of treat- ments. Acta Psychiatr Scand 40:211-216 (1964). 6. Dinc, H. I

  2. Increased expression of a plant actin gene during a biotrophic interaction between round-leaved mallow, Malva pusilla, and Colletotrichum gloeosporioides f. sp. malvae.

    PubMed

    Jin, S; Xu, R; Wei, Y; Goodwin, P H

    1999-10-01

    Two actin genes, actA from the hemibiotrophic anthracnose fungus, Colletotrichum gloeosporioides (Penz.) Penz. & Sacc. f. sp. malvae, and act1 from its host, Malva pusilla (Sm.) were cloned from a cDNA library developed from infected host tissue. The actin gene, actA, of C. gloeosporioides f. sp. malvae, which is similar to that of other euascomycetes, appears to be expressed constitutively. The actin gene of M. pusilla is most similar to one of the actin genes of Arabidopsis thaliana that is unique in being responsive to environmental stimuli such as wounding. Expression of actA was used to follow the growth of the fungus in the plant tissue. Low actA expression occurred until 72-96 h after inoculation and then increased rapidly, corresponding with the timing of the shift from slower biotrophic fungal growth to much more rapid necrotrophic growth. In contrast, expression of act1 approximately doubled during the biotrophic phase and then rapidly declined during the necrotrophic phase. Increased host actin expression could be due to host cytoskeleton rearrangement in response to biotrophic infection, and the subsequent decrease in host actin expression could be due to host cell disruption resulting from tissue maceration during necrosis. This is the first report of a host actin gene that can increase in expression during a compatible plant-pathogen interaction.

  3. The Cost of Chaos in the Curriculum. Perspectives on Higher Education

    ERIC Educational Resources Information Center

    Capaldi Phillips, Elizabeth D.; Poliakoff, Michael B.

    2015-01-01

    ACTA's report "The Cost of Chaos in the Curriculum" reveals that the vast array of course choices given to college students is a cause of exploding costs and poor academic outcomes. And a bloated undergraduate curriculum is particularly detrimental to the success of students from lower socioeconomic backgrounds. The report documents how…

  4. AFRRI (Armed Forces Radiobiology Research Institute) Reports, October, November, December 1986

    DTIC Science & Technology

    1986-12-01

    55,492 Beer, M., Stern, S., Carmalt, D. & Mohlhenrich, K. H. (1966) Biochemistry 5, 2283-2288 Behrend, R. & Roosen, O. (1889) Justus Liebigs Ann. Chem...227, 375-381 Chang, C. H., Ford, H. & Behrman, E. J. (1981) Inorg. Chim. Acta 55, 77-80 Criegee, R. (1936) Justus Liebigs Ann. Chem. 522, 75-93

  5. Final Sequestration Report for Fiscal Year 2013

    DTIC Science & Technology

    2013-03-01

    program integrity initiatives. In addition, on August 20, 2012, OMB released its estimate of the maxi - mum extent to which the caps for 2013 can be...With those reductions, the overall limit on discretionary 2014 2015 2016 2017 2018 2019 2020 2021 Caps Set in the Deficit Control Acta Defense

  6. Bold Leadership Real Reform [Annual Report, 2014

    ERIC Educational Resources Information Center

    American Council of Trustees and Alumni, 2015

    2015-01-01

    Higher education has never been more "front and center"--almost daily we hear about spiraling costs, the lack of academic rigor, and the stifling political correctness on our college campuses. Long before such issues were hot, ACTA [American Council of Trustees and Alumni] was already pointing out these worrisome trends and calling on…

  7. Genetics Home Reference: cap myopathy

    MedlinePlus

    ... fibers and are important for muscle contraction. Attachment (binding) and release of the overlapping thick and thin filaments allows them to move relative to each other so that the muscles can contract. The mutation in the ACTA1 gene that causes ...

  8. Genetics Home Reference: intranuclear rod myopathy

    MedlinePlus

    ... fibers and are important for muscle contraction. Attachment (binding) and release of the overlapping thick and thin filaments allows them to move relative to each other so that the muscles can contract. ACTA1 gene mutations that cause intranuclear rod myopathy ...

  9. Genetics Home Reference: actin-accumulation myopathy

    MedlinePlus

    ... fibers and are important for muscle contraction. Attachment (binding) and release of the overlapping thick and thin filaments allows them to move relative to each other so that the muscles can contract. ACTA1 gene mutations that cause actin-accumulation myopathy ...

  10. Ruthenium Oxide-Based Microelectrochemical Devices: Electrochemical Behavior of the Oxide Formed by Reduction of RuO4(2-)

    DTIC Science & Technology

    1988-08-15

    Pizzini, S.; Buzzana , G.; Marl, C.; Rossi, K.; Torcho, S. Mat. Res. Bull., 1972, 7, 449. * 10. Sze, S. M. Physics of Semiconductor Devices, 2nd Edition...Kim, K.S.; Winograd, N. J. Catal., 1974, 35, 66; (b) Folkesson, B. Acta Chem. Scand. 1973, 27, 287. 13. (a) Trassati, S.; Buzzana , G. J. Electroanal

  11. Finding of No Significant Impact and Environmental Assessment for Flight Test to the Edge of Space

    DTIC Science & Technology

    2008-12-01

    Tech, Inc.,501 Soledad ,San Antonio,TX,78205 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) Dr...PERFORMING ORGANIZATION REPORT NUMBER Jim Knight Tetra Tech, Inc. 501 Soledad San Antonio, TX 78205 Jerry Haber ACTA Inc. 2790 Skypark

  12. Spectrochemical Measurements with Multichannel Integrating Detectors.

    DTIC Science & Technology

    1987-05-26

    The practical limit is set by cosmic rays and nuclear decay events that obscure the image. In practice, the long term - 10 - drift (low frequency 1/f...SturbriOge, Massachusetts. 14. R.8. Bilnorn, P.M. Epperson and M.8. Denton, Spectrocnim. Acta (1987), submitted. 15. EGAG Reticon , Image Sensing Products

  13. Precipitation Under Cyclic Strain in Solution-Treated Al-4wt%Cu II: Precipitation Behavior

    DTIC Science & Technology

    2009-02-01

    Physics A. 37:1, 31-36, (1985). 4. JB Murphy, Acta Met. 9, 563 (1961). 5. MS Anand, SP Muraka and RP Agarwala. J appl . Phys. 36, 3860 (1965). 6. M...Interphase Boundaries.” Metals Sci. J. 2, 155-158. (1968). 10. Ramanathan Sankaran. Misfit Dislocation Structures, Growth Kinetics, and Morphology of

  14. An Animal-to-Human Scaling Law for Blast-Induced Traumatic Brain Injury Risk Assessment

    DTIC Science & Technology

    2014-10-28

    02139; and cSoldier Protection and Individual Equipment , Program Executive Office Soldier, US Army, Fort Belvoir, VA 22060 Contributed by John D... Biomedical Imaging (IEEE, Piscataway, NJ), Vol 53, pp 1142–1145. 39. Prevost TP, Balakrishnan A, Suresh S, Socrate S (2011) Biomechanics of brain tissue. Acta

  15. Editor's note

    NASA Astrophysics Data System (ADS)

    Umapathy, Siva

    2017-01-01

    This is an editor's note related to the publication 'Biologically active and thermally stable polymeric Schiff base and its metal polychelates: Their synthesis and spectral aspects' by Raza Rasool and Sumaiya Hasnain, which appeared in Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 148 (2015) 435-443.

  16. Rapid, Femtomolar Bioassays in Complex Matrices ComBining Microfluidics and Magnetoelectronics

    DTIC Science & Technology

    2007-03-22

    environmental monitoring (Baeumner, 2003; Farre and Barcelo , 2003). The diversity of applications and sample matrices results in a nonuniform set of...Erickson, D., Li, D.Q., 2004. Analytica Chimica Acta 507, 11-26. Farre, M., Barcelo , D., 2003. Trac-Trends In Analytical Chemistry 22, 299-310

  17. Ignition of Nanocomposite Thermites by Electric Spark and Shock Wave

    DTIC Science & Technology

    2014-04-30

    Thermochim. Acta 2011, 521, 125. [15] P. Swaminathan, M. D. Grapes , K. Woll, S. C. Barron, D. A. Lavan, T. P. Weihs, Studying Exothermic Reactions in...the Ni-Al System at Rapid Heating Rates Using a Nanocalorimeter, J. Appl. Phys. 2013, 113, 143509. [16] M. Vohra, M. Grapes , P. Swaminathan, T. P

  18. Approaches to Cell Biology Teaching: Mapping the Journey--Concept Maps as Signposts of Developing Knowledge Structures

    ERIC Educational Resources Information Center

    Allen, Deborah; Tanner, Kimberly

    2003-01-01

    An instructor contemplating a course transformation to incorporate a student-centered learning environment may feel faced with what seems like a high-wire balancing act--a constantly renegotiated compromise between students' legitimate needs for structure, well-understood expectations, and good grades and instructors' foreknowledge that the path…

  19. Superplasticity - A Fundamental Investigation on Deformation Mechanism and Cavitation Phenomena.

    DTIC Science & Technology

    1988-02-15

    also be estimated from Fib. lb using approaches suggested by Mohamad [8] and Nardone et al [9]. Following Mohamad [8], a threshold stress was derived...ASM, Uj, (1969), 291. 8 F.A. Mohamed, J. Mat. Sci., 8, (1983), 582. r. .. •., • is. 22 9. V.C. Nardone , D.E. Matejczyk, and J.K. Tien, Acta Metall., 2

  20. Yersinia pestis YopD 150-287 Fragment is Partially Unfolded in the Native State

    DTIC Science & Technology

    2007-11-17

    Hoiczyk, G. Blobel, Polymerization of a single protein of the pathogen Yersinia enterocolitica into needles punctures eukaryotic cells, Proc. Natl...12] C.B. Trame, D.B. McKay, Structure of the Yersinia enterocolitica molecular-chaperone protein SycE, Acta Crystallogr. D Biol. Crys- tallogr. 59

  1. Eventos de Agosto (August Events).

    ERIC Educational Resources Information Center

    Toro, Leonor; Pla, Myrna

    Written in Spanish, this booklet contains brief information on seven August events celebrated by Puerto Ricans: Herbert Hoover's birthdate (August 10); Acta del Seguro Social (Social Security Act, August 14); Julian E. Blanco (August 14), Enmienda 19 Sufragia de la Mujer (Amendment 19, Women's Suffrage, August 26); Benjamin Harrison (August 20);…

  2. Crystal Field Study of Gd(3+)-Doped La(x)RE(1-x)F3 (RE=Ce,Pr,Nd) Single Crystals

    DTIC Science & Technology

    2001-01-01

    the vacuum ultraviolet:LalCeF 3 " Appl. Optics 12, pp. 138-139, 1973. 6. W. Korczak and P. Mikolajczak , "Crystal growth and temperature variation of...spin-phonon interactions and spin-lattice relaxations" Acta Phys. Pol. A 95, pp. 367-380, 1999. 12. L. E. Misiak, S. K. Misra and P. Mikolajczak

  3. Development of Guidance for States Transitioning to New Safety Analysis Tools

    ERIC Educational Resources Information Center

    Alluri, Priyanka

    2010-01-01

    With about 125 people dying on US roads each day, the US Department of Transportation heightened the awareness of critical safety issues with the passage of SAFETEA-LU (Safe Accountable Flexible Efficient Transportation Equity Act--A Legacy for Users) legislation in 2005. The legislation required each of the states to develop a Strategic Highway…

  4. Generation and Evaluation of PEGylated Recombinant Human Acetylcholinesterase as an Optimal OP-Bioscavenger

    DTIC Science & Technology

    2009-04-27

    acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target. Structure 3:1355-1366. 24 Kronman, C., Velan, B... snake venom toxin fasciculin-II. ACTA Cryst. D56: 1385-1394. Li, B., Stribley, J.A., Ticu, A., Xie, W., Schopfer, L.M., Hammond, P., Brimijoin, S

  5. Diffusive Insights: On the Disagreement of Christian Bohr and August Krogh at the Centennial of the Seven Little Devils

    ERIC Educational Resources Information Center

    Gjedde, Albert

    2010-01-01

    The year 2010 is the centennial of the publication of the "Seven Little Devils" in the predecessor of "Acta Physiologica". In these seven papers, August and Marie Krogh sought to refute Christian Bohr's theory that oxygen diffusion from the lungs to the circulation is not entirely passive but rather facilitated by a specific cellular activity…

  6. Determinants of Infectivity of Pathogens in Vector Ticks

    DTIC Science & Technology

    1990-11-15

    andersonistiles. Part II. The feeding mechanism in relation to the host. Acta trop. 17: 72-79. Holt, S.C. (1978). Anatomy and chemistry of spirochetes...Helminthol. 40:337-342. Lees, A.D. (1948). The sensory phisiology of the sheep Ixodes ricinus L. J. Exp. Biol. 25:145-207. Lemaux, P.G., Herendeen, S.L

  7. Ultra Low Thermal Expansion Ceramics

    DTIC Science & Technology

    1986-07-01

    Lars-Ove Hagman and P. Kierkegaard , Acta Chem. Scand. 22, 1822 (1968). 5. J. Alamo and R. Roy, 3. Mat. Sci. 21, 444 (1986). 6. D.K. Agrawal and R...caticns (1-3). Earlier, Hagman and KierKegaard ( ) had synthesized saGe P3 3 and determied its crystal structure by using a single crystal. hev had

  8. Synthesis of New Solid Electrolytes.

    DTIC Science & Technology

    1982-03-01

    Subsequently, some of these new peaks were identified as the peaks belonging to the 3 x 3 cubic superstructure first described by Kierkegaard 2 . In...34 ’ I i " I II i REFERENCES 1. C. Bush, B . S.- Thesis, Polytechnic institute of New York, 1977. 2. L. Hagman and P. Kierkegaard , Acta Chem

  9. Two Week Oral Dose Range-Finding Toxicity Study of WR269410 in Rats

    DTIC Science & Technology

    1993-07-09

    Clin. Chem. Acta, 4_L 209, 1972 Total Protein Biuret technique Ciba-Corning 550 Express Clinical Chemistry System Kingsley, G.J. Lab. Clin. Med. 27...Triglvcerides Methodology of Nagele, et al & a final Trinder reaction . Ciba-Corning 550 Express Clinical Chemistry System Nagele, U., Hagele, E. O., et al

  10. Solidification Structure Synthesis in Undercooled Liquids

    DTIC Science & Technology

    1993-10-18

    Perepezko in "Rapidly Solidifying Alloys", ed. H. Liebermann (Marcel Dekker, NY), 17 (1993). 13. "Nucleation Kinetics in Undercooled Liquid Metals and...Acta Met., 22, 677 (1974). 93. H. J. Schurhoff, W. Gruhl and W. G. Burchard , Z Metallkde., 74, 132 (1983). 94. 0. M. Suirez. M. S. Thesis, University

  11. Control of Venous Thromboembolism and Metastasis in Breast Cancer by Anti-Fibrinolysis Mechanism

    DTIC Science & Technology

    2010-11-01

    1990;87:7235-9. 7 Scanlan MJ, Raj BK, Calvo B, Garin-Chesa P, Sanz-Moncasi MP, Healey JH, Old LJ, Rettig WJ. Molecular cloning of fibroblast activation... Molecular cloning of seprase: A serine integral membrane protease from human melanoma, Biochimica et Biophysica Acta, 1997;1361:11-9. 10

  12. Wavelength Dependence on the Forensic Analysis of Glass by Laser Induced Breakdown Spectroscopy

    DTIC Science & Technology

    2009-10-29

    spectroscopy [2,4], atomic absorption spectroscopy (AAS) [3], x - ray fluorescence ( XRF ) [3,4], neutron activation analysis (NAA) [5...micro X - ray fluorescence spectroscopy , and laser induced breakdown spectroscopy for the discrimination of automotive glass,” Spectrochim. Acta Part...refractive index, energy dispersive X - ray fluorescence and inductively coupled plasma atomic emission spectrometry for forensic characterization

  13. Governance for a New Era: A Blueprint for Higher Education Trustees

    ERIC Educational Resources Information Center

    Schmidt, Benno C.

    2014-01-01

    "Governance for a New Era: A Blueprint for Higher Education Governance," is the product of a summit facilitated by ACTA [American Council of Trustees and Alumni] and chaired by Benno Schmidt, City University of New York Board chairman. Signatories to the statement, a diverse group of 22 distinguished national leaders, include college…

  14. Near-Unity Quantum Yields for Intersystem Crossing and Singlet Oxygen Generation in Polymethine-like Molecules: Design and Experimental Realization

    DTIC Science & Technology

    2010-01-01

    Oliveira, A. S.; Vieira Ferreira, L. F. Synthesis and Photoche- mical Evaluation of Iodinated Squarylium Cyanine Dyes. Helv. Chim. Acta 2005, 88, 1135...Generation Ability of Squar- ylium Cyanine Dyes. J. Photochem. Photobiol., A 2003, 160, 159–161. (18) Drobizhev, M.; Stepanenko, Yu.; Dzenis, Yu.; Karotki, A

  15. Supernumerary maxillary and Mandibular Fourth Molars.

    DTIC Science & Technology

    1981-09-23

    of agenesis and polygenesis in the primate dentition . Am J Phys Anthropol 38:671-679, 1973. 10. Bohn, A.: Hyperdontia. Acta Odontol Scand 21(Suppl 38...Company. 12. Luten, J.R.: The prevalence of supernumerary teeth in primary and mixed dentitions . J Dent Child 9:346-353, 1967. LEGEND Fig 1 Impacted

  16. Regenerative Medicine and Restoration of Joint Function

    DTIC Science & Technology

    2013-10-01

    applications in bone replacement and repair. Acta Biomater 2011;7:16–30. 4. Dobbs HS, Robertson JLM. Heat treatment of cast Co-Cr-Mo for...2012;19(3):283-90. 45. Seymour PA, Freude KK, Dubois CL, Shih HP, Patel NA, Sander M. A dosage-dependent requirement for Sox9 in pancreatic

  17. Dimethylnitrosamine Detection and Measurement Using Laser Raman Spectroscopy

    DTIC Science & Technology

    1976-12-10

    instrumental APPLIED SPECTROSCOPY 517 . , ! , ,, - ..... ... . .T r ,,d .I I,. *, L *i, - 7 ...... settings, solution preparation, and actual measurement each...nitrosamines; however, these other interferents 5. P Rodemacher and W Luttke, Spectrochim Acta 27, 715 (1971) 59 518 Volume 31 Number 6, 1977 APPLIED SPECTROSCOPY

  18. Expression of concern

    NASA Astrophysics Data System (ADS)

    2017-02-01

    This is an expression of concern related to the following publications: Nanostructures formed by cyclodextrin covered procainamide through supramolecular self assembly - Spectral and molecular modeling study (2015) Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 136 (PB), pp. 875-883, by Rajendiran, N., Mohandoss, T., Sankaranarayanan, R.K.

  19. Bedside calculation of hemodynamic parameters with a hand-held programmable calculator. Part I.: Choice of hemodynamic formulas.

    PubMed

    Laurent, M

    1980-01-01

    Currently used hemodynamic and oxygen transport formulas are reviewed in order to chose the shortest form compatible with an optimal clinical accuracy. Programming of hand held calculators with these selected equations spares steps available in the program memory. (Acta anaesth. belg., 1980, 31, 45-52).

  20. On the existence of ‘L-alanine cadmium bromide'

    NASA Astrophysics Data System (ADS)

    Srinivasan, Bikshandarkoil R.

    2013-12-01

    It is argued that the recently reported nonlinear optical crystal L-alanine cadmium bromide, grown by slow solvent evaporation method at room temperature [P. Ilayabarathi, J. Chandrasekaran, Spectrochim. Acta 96A (2012) 684-689] is the well-known L-alanine crystal. The isolation of L-alanine crystal is explained due to fractional crystallization.

  1. On the existence of 'L-alanine cadmium bromide'.

    PubMed

    Srinivasan, Bikshandarkoil R

    2013-12-01

    It is argued that the recently reported nonlinear optical crystal L-alanine cadmium bromide, grown by slow solvent evaporation method at room temperature [P. Ilayabarathi, J. Chandrasekaran, Spectrochim. Acta 96A (2012) 684-689] is the well-known L-alanine crystal. The isolation of L-alanine crystal is explained due to fractional crystallization.

  2. Vigilance, Precaution and Routine Behavior - The Socio-cultural Impact

    DTIC Science & Technology

    2011-03-01

    H., Mort, J. and Eilam, D. Obsessive - Compulsive Disorder ( OCD ): A disorder of pessimal (non-functional) motor behavior. Acta Psychiatrica... compulsive cleaning and compulsive checking in obsessive - compulsive disorder . European Neuropsychopharmacology, in press. 4. Eilam, D., Izhar, R., and...everyday routines: The counterpart of compulsive rituals. Behavioural Brain Research, 212 (2010): 90-95. 2. Zor, R., Keren, H., Hermesh, H., Szechtman

  3. Liquid Propellant Blast Yields for Delta IV Heavy Vehicles

    DTIC Science & Technology

    2010-07-01

    exterior shells shown in a layered construction. Unfortunately, the 3D model is too computationally intensive to run on a PC, and may even be too large to...Research Triangle Institute, Cocoa Beach, FL, 30 July 2004. LIQUID PROPELLANT BLAST YIELDS FOR DELTA IV HEAVY VEHICLES Ron R. Lambert ACTA Lompoc, CA

  4. Automatic Verification of Serializers.

    DTIC Science & Technology

    1980-03-01

    Programming Languages, Academic Press, New York, 1968. Dijkstra 71 E. Dijkstra, Hierarchical Ordering of Sequential Processes, Acta Informatica , vol. 1...Programming Languages, Las Vegas, January 1980, 174-185. Lanipson and Redell 79 B. Lanipson, 1). RedelI , Experience with monitors and processes in

  5. Reconfigurable Wires

    DTIC Science & Technology

    2004-12-31

    switches to minimize the number required in a given protosat; • Low-cost inertial reference sensors for limited ability to support intrinsic attitude...p. 154. 88 C. Angus, Brit. J. Appl. Phys. 13, 58 (19 89 D. Maugis and H. M. Pollock , Acta metall. (USA). 32, 1323 (1984). 90 A. Tonck, F. H 91 J

  6. Experiences of a local arrangement committee for a large scientific conference

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This paper is an an invited condensation of a paper that appeared in Acta. Hort. 745: 513-532 last year. It describes the history and organization of the combined meeting of the 90th Annual Meeting of the Potato Association of America, the VI International Solanaceae Conference, and the III Solanace...

  7. Curing of Graphite/Epoxy Composites.

    DTIC Science & Technology

    1983-03-01

    365-371 (1973). 21. Pappalardo , L. T., "DSC Evaluation of B-Stage Epoxy-Glass Prepregs For Multilayer Boards," SPE Technical Papers, 20, 13-16 (1974...Kamal, M. R., "Differential Scanning Calorimetry of Epoxy Cure: Isothermal Cure Kinetics," Thermochimica Acta, 14, 41-59 (1976). 24. Pappalardo , L. T

  8. Complexation Reactions Between Trace Metals and Specific Functional Groups in Natural Organic Matter from Estuarine Waters

    DTIC Science & Technology

    2001-09-30

    pre-concentration by lyophilization. Analyt. Chim. Acta, 427, 111-117. Hung, C.-C., Guo, L., Santschi, P.H., Alvarado- Quiroz , N., Pinckney, J., and...Santschi, P.H., Alvarado- Quiroz , N., Haye, J., Pinckney, J., Lumsden, B., and Walsh, I. 2001. Production and distribution of total carbohydrates and

  9. Separation of Strontium from Calcium by Ion-Exchange in the Presence of Complex III - USSR .

    DTIC Science & Technology

    2007-11-02

    height of_the cationite was 100 mm. In order to convert" the resin into tbe BEL-form an ammoniacal solution of 0.02 M M)TA at a pH of 10 was run...Inorganic Analysis, State Chemical" Publishing House, Moscow, 19;/. W *• Singbom, E. Wanninen, Analyt. chinn acta..^ l ^Ai’* ; (reference: H. Fribil

  10. Basal Ganglia Dopamine-gamma-Aminobutyric Acid-Acetylcholine Interaction in Organophosphate-Induced Neurotoxicity. Appendices

    DTIC Science & Technology

    1982-12-01

    chollnerglc (excitatory) mechanisms Interact In a delicate way to maintain the normal function of strlatum ( Anden et a1_., 1966). The strlatal...Acad. Sd_ 100, 314-320. Anden N. E., Oahlstrom A. L., Fuxe K. and Larsson K. (1966) Functional role of the n1gro-neostr1atal dopamlne neurons. Acta

  11. Nanostructuring of Aluminum Alloy Powders by Cryogenic Attrition with Hydrogen-Free Process Control Agent

    DTIC Science & Technology

    2015-02-01

    24 h (Fig. 5). This indicates that before or at 8 h of cryomilling time, there is a balance in the rate of the respective fracturing and cold welding...Thermal stability of nano -RuAl produced by mechanical alloying. Acta Materialia. 2001;49(3):395–403. 11. Natter H, Schmelzer M, Löffler M, C Krill

  12. A Partial Exploration of the Potential Energy Surfaces of SCN and HSCN: Implications for the Enzyme-Mediated Detoxification of Cyanide

    DTIC Science & Technology

    2009-01-01

    its role in toxicology , Tox. Sci. 78 (2004) 185–188. [6] (a) B.H. Sorbo, Crystalline rhodanese. I. Purification and physicochemical exam- ination, Acta...the devel- opment of quantitative structure–activity relationships ( QSARs ). pKa-values of phenols and aromatic and aliphatic carboxylic acids, Chemosphere 19 (1989) 1595.

  13. The Metalloprotease Mpl Supports Listeria monocytogenes Dissemination through Resolution of Membrane Protrusions into Vacuoles

    PubMed Central

    Alvarez, Diego E.

    2016-01-01

    Listeria monocytogenes is an intracellular pathogen that disseminates within the intestinal epithelium through acquisition of actin-based motility and formation of plasma membrane protrusions that project into adjacent cells. The resolution of membrane protrusions into vacuoles from which the pathogen escapes results in bacterial spread from cell to cell. This dissemination process relies on the mlp-actA-plcB operon, which encodes ActA, a bacterial nucleation-promoting factor that mediates actin-based motility, and PlcB, a phospholipase that mediates vacuole escape. Here we investigated the role of the metalloprotease Mpl in the dissemination process. In agreement with previous findings showing that Mpl is required for PlcB activation, infection of epithelial cells with the ΔplcB or Δmpl strains resulted in the formation of small infection foci. As expected, the ΔplcB strain displayed a strong defect in vacuole escape. However, the Δmpl strain showed an unexpected defect in the resolution of protrusions into vacuoles, in addition to the expected but mild defect in vacuole escape. The Δmpl strain displayed increased levels of ActA on the bacterial surface in protrusions. We mapped an Mpl-dependent processing site in ActA between amino acid residues 207 to 238. Similar to the Δmpl strain, the ΔactA207–238 strain displayed increased levels of ActA on the bacterial surface in protrusions. Although the ΔactA207–238 strain displayed wild-type actin-based motility, it formed small infection foci and failed to resolve protrusions into vacuoles. We propose that, in addition to its role in PlcB processing and vacuole escape, the metalloprotease Mpl is required for ActA processing and protrusion resolution. PMID:27068088

  14. Proliferation of rat small hepatocytes requires follistatin expression.

    PubMed

    Ooe, Hidekazu; Chen, Qijie; Kon, Junko; Sasaki, Kazunori; Miyoshi, Hiroyuki; Ichinohe, Norihisa; Tanimizu, Naoki; Mitaka, Toshihiro

    2012-06-01

    Small hepatocytes (SHs) are a subpopulation of hepatocytes that have high growth potential in culture and can differentiate into mature hepatocytes (MHs). The activin (Act)/follistatin (Fst) system critically contributes to homeostasis of cell growth in the normal liver. ActA and ActB consist of two disulfide-linked Inhibin (Inh)β subunits, InhβA and InhβB, respectively. Fst binds to Act and blocks its bioactivity. In the present study we carried out the experiments to clarify how Fst regulates the proliferation of SHs. The gene expression was analyzed using DNA microarray analysis, reverse transcription-polymerase chain reaction (RT-PCR) and real-time PCR, and protein expression was examined by western blots, immunocytochemistry, and enzyme-linked immunosorbent assay. RT-PCR showed that Fst expression was high in SHs and low in MHs. Although the ActA expression was opposite to that of Fst, ActB expression was high in SHs and low in MHs and increased with time in culture. Fst protein was detected in the cytoplasm of SHs and secreted into the culture medium. ActB protein was also secreted into the medium. Although the exogenous administration of ActA and ActB apparently suppressed the proliferation of SHs, apoptosis of SHs was not induced by treatment with ActA or ActB. On the other hand, Fst treatment did not affect the colony formation of SHs but prevented the inhibitory effect of ActA. Neutralization by the anti-Fst antibody resulted in the suppression of DNA synthesis in SHs, and small hairpin RNA against Fst suppressed the expansion of SH colonies. In conclusion, Fst expression is necessary for the proliferation of SHs.

  15. A Case of Ischemic Colitis Associated with the Herbal Food Supplement Ma Huang

    PubMed Central

    Song, Hyun Joo; Ryu, Kum Hei; Kim, Tae Hun; Jung, Sung-Ae; Yoo, Kwon

    2008-01-01

    Ischemic colitis is a condition that usually occurs in the elderly, as a form of vascular disease. However, ischemic colitis also occurs, though rarely, in healthy young adults. Moreover, food supplements containing Ephedra sinica or ma huang have been linked to adverse central nervous and cardiovascular events. A 40-year-old man was admitted to our emergency department after 2 episodes of abdominal pain and bloody diarrhea that lasted 24 hours. His medical history was unremarkable for risk factors of bowel ischemia, except for well-controlled hypertension. However, a weight-loss supplement, Ephedra sinica, had been prescribed for daily use during the previous month. Both abdominal/pelvic computed tomography and colonoscopy revealed findings compatible with ischemic colitis. His conditions spontaneously improved without any serious complications, and he was advised to discontinue the use of herbal medications containing ephedrine. In this paper, we describe a case of ischemic colitis that was potentially linked to the use of ma huang with a review of the relevant literature. PMID:18581601

  16. International Symposium on Grids and Clouds (ISGC) 2014

    NASA Astrophysics Data System (ADS)

    The International Symposium on Grids and Clouds (ISGC) 2014 will be held at Academia Sinica in Taipei, Taiwan from 23-28 March 2014, with co-located events and workshops. The conference is hosted by the Academia Sinica Grid Computing Centre (ASGC).“Bringing the data scientist to global e-Infrastructures” is the theme of ISGC 2014. The last decade has seen the phenomenal growth in the production of data in all forms by all research communities to produce a deluge of data from which information and knowledge need to be extracted. Key to this success will be the data scientist - educated to use advanced algorithms, applications and infrastructures - collaborating internationally to tackle society’s challenges. ISGC 2014 will bring together researchers working in all aspects of data science from different disciplines around the world to collaborate and educate themselves in the latest achievements and techniques being used to tackle the data deluge. In addition to the regular workshops, technical presentations and plenary keynotes, ISGC this year will focus on how to grow the data science community by considering the educational foundation needed for tomorrow’s data scientist. Topics of discussion include Physics (including HEP) and Engineering Applications, Biomedicine & Life Sciences Applications, Earth & Environmental Sciences & Biodiversity Applications, Humanities & Social Sciences Application, Virtual Research Environment (including Middleware, tools, services, workflow, ... etc.), Data Management, Big Data, Infrastructure & Operations Management, Infrastructure Clouds and Virtualisation, Interoperability, Business Models & Sustainability, Highly Distributed Computing Systems, and High Performance & Technical Computing (HPTC).

  17. International Symposium on Grids and Clouds (ISGC) 2016

    NASA Astrophysics Data System (ADS)

    The International Symposium on Grids and Clouds (ISGC) 2016 will be held at Academia Sinica in Taipei, Taiwan from 13-18 March 2016, with co-located events and workshops. The conference is hosted by the Academia Sinica Grid Computing Centre (ASGC). The theme of ISGC 2016 focuses on“Ubiquitous e-infrastructures and Applications”. Contemporary research is impossible without a strong IT component - researchers rely on the existence of stable and widely available e-infrastructures and their higher level functions and properties. As a result of these expectations, e-Infrastructures are becoming ubiquitous, providing an environment that supports large scale collaborations that deal with global challenges as well as smaller and temporal research communities focusing on particular scientific problems. To support those diversified communities and their needs, the e-Infrastructures themselves are becoming more layered and multifaceted, supporting larger groups of applications. Following the call for the last year conference, ISGC 2016 continues its aim to bring together users and application developers with those responsible for the development and operation of multi-purpose ubiquitous e-Infrastructures. Topics of discussion include Physics (including HEP) and Engineering Applications, Biomedicine & Life Sciences Applications, Earth & Environmental Sciences & Biodiversity Applications, Humanities, Arts, and Social Sciences (HASS) Applications, Virtual Research Environment (including Middleware, tools, services, workflow, etc.), Data Management, Big Data, Networking & Security, Infrastructure & Operations, Infrastructure Clouds and Virtualisation, Interoperability, Business Models & Sustainability, Highly Distributed Computing Systems, and High Performance & Technical Computing (HPTC), etc.

  18. Comparison of contents of five ephedrine alkaloids in three official origins of Ephedra Herb in China by high-performance liquid chromatography.

    PubMed

    Hong, Hao; Chen, Hu-Biao; Yang, Dong-Hui; Shang, Ming-Ying; Wang, Xuan; Cai, Shao-Qing; Mikage, Masayuki

    2011-07-01

    In the present paper, a fast and economical HPLC method [on a Phenomenex Polar-RP column with a solution of (phosphoric acid:triethylamine:dibutylamine:water = 0.40:0.1:0.2:499.3) and methanol] is developed, and applied for the determination of norephedrine, norpseudoephedrine, ephedrine (E), pseudoephedrine (PE) and methylephedrine (ME) in 64 samples of three species from main habitats in China. Quantitation data showed that total alkaloid content in Ephedra equisetina Bge. (2.708 ± 0.642%) is higher than that in E. sinica Stapf. (1.365 ± 0.624%) and E. intermedia Schrenk et C. A. Mey. (1.537 ± 0.746%), but the range of total alkaloid content in each species is so wide that the ranges of the three species greatly overlap. The contents of E, PE and ME are different among the three species. The ratio E/total alkaloid content and ratio E/PE as well as E and ME contents can be used for identification of E. sinica, E. intermedia and E. equisetina from one another.

  19. Liquid chromatography-particle beam electron ionization mass spectrometry method for analysis of botanical extracts: evaluation of ephedrine alkaloids in standard reference materials.

    PubMed

    Castro, Joaudimir; Krishna, M V Balarama; Marcus, R Kenneth

    2010-01-01

    The preliminary validation of a high-performance liquid chromatography particle beam mass spectrometry method (HPLC-PB/MS) with electron impact ionization source for analysis of botanical extracts is presented. The LC-PB/MS system was evaluated for the analysis of ephedrine alkaloids using ephedra-containing National Institute of Standards and Technology dietary supplement standard reference materials (SRMs) 3241 Ephedra Sinica Stapf Native Extract and 3242 Ephedra Sinica Stapf Commercial Extract. The ephedrine alkaloids were separated by reversed-phase chromatography using a phenyl column at room temperature. A linear gradient method with a mobile phase composition varying from 5:95 [MeOH:0.1% trifluoroacetic acid (TFA) in water] to 20:80 (MeOH:0.1% TFA in water) at a flow rate of 1.0 ml/min, with an analysis time of less than 20 min, was used. The source block temperature was evaluated to determine the optimal operating conditions by monitoring the intensities and fragmentation patterns of the ephedrine alkaloids. Ephedrine and N-methylephedrine were taken as a representative of the test alkaloids. The LODs on the sub-nanogram level were achieved, with ephedrine, pseudoephedrine, and methylephedrine in the SRMs quantified by a standard addition method with recoveries of > or = 86% and RSDs of < or = 14% (n = 3).

  20. Recognition of two classes of oligoproline sequences in profilin- mediated acceleration of actin-based Shigella motility

    PubMed Central

    1996-01-01

    The gram negative rod Shigella flexneri uses it surface protein IcsA to induce host cell actin assembly and to achieve intracellular motility. Yet, the IcsA protein lacks the oligoproline sequences found in ActA, the surface protein required for locomotion of the gram positive rod Listeria monocytogenes. Microinjection of a peptide matching the second ActA oligoproline repeat (FEFPPPPTDE) stops Listeria locomotion (Southwick, F.S., and D.L. Purich. 1994a. Proc. Natl. Acad. Sci. USA. 91:5168-5172), and submicromolar concentrations (intracellular concentration 80-800 nM) similarly arrest Shigella rocket-tail assembly and intracellular motility. Coinjection of a binary solution containing profilin and the ActA analogue increased the observed rates of intracellular motility by a factor of three (mean velocity 0.90 +/- 0.07 mu m/s, SD n=16 before injection vs 0.3 +/- 0.1 mu m/s, n=33 postinjection, intracellular concentration = 80 nM profilin plus 80 nM ActA analogue). Recent evidence suggests the ActA analogue may act by displacing the profilin-binding protein VASP (Pistor, S.C., T. Chakaborty, V. Walter, and J. Wehland. 1995. Curr. Biol. 5:517-525). At considerably higher intracellular concentrations (10 muM), the VASP oligoproline sequence (GPPPPP)3 thought to represent the profilin- binding site (Reinhard, M., K. Giehl, K. Abel, C. Haffner, T. Jarchau, V. Hoppe, B.M. Jockusch, and U. Walter. 1995. EMBO (Eur. Mol. Biol. Organ.) J. 14:1583-1589) also inhibited Shigella movement. A binary mixture of the VASP analogue and profilin (each 10 muM intracellular concentration) led to a doubling of Shigella intracellular migration velocity (0.09 +/- 0.06 mu m/s, n = 25 preinjection vs 0.18 +/- 0.10 mu m/s, n = 61 postinjection). Thus, the two structurally divergent bacteria, Listeria and Shigella, have adopted convergent mechanisms involving profilin recognition of VASP oligoproline sequences and VASP recognition of oligoproline sequences in ActA or an ActA-like host protein

  1. Determination of Ephedrine Alkaloids in Botanicals and Dietary Supplements by HPLC-UV

    PubMed Central

    Roman, Mark C.; Gray, D.; Luo, G.; McClanahan, R.; Perez, R.; Roper, C.; Roscoe, V.; Shevchuk, C.; Suen, E.; Sullivan, D.; Walther, H.J.

    2008-01-01

    An international collaborative study was conducted of a high-performance liquid chromatography (HPLC)-UV method for the determination of the major (ephedrine [EP] and pseudoephedrine [PS]) and minor (norephedrine [NE], norpseudoephedrine [NP], methylephedrine [ME], and methylpseudoephedrine [MP]) alkaloids in selected dietary supplements representative of the commercially available products. Ten collaborating laboratories determined the ephedrine-type alkaloid content in 8 blind replicate samples. Five products contained ephedra ground herb or ephedra extract. These 5 products included ground botanical raw material of Ephedra sinica, a common powdered extract of Ephedra sinica, a finished product containing only Ephedra sinica ground botanical raw material, a complex multicomponent dietary supplement containing Ma Huang, and a high-protein chocolate flavored drink mix containing Ma Huang extract. In addition, collaborating laboratories received a negative control and negative control spiked with ephedrine alkaloids at high and low levels for recovery studies. Test extracts were treated to solid-phase extraction using a strong-cation exchange column to help remove interferences. The HPLC analyses were performed on a polar-embedded phenyl column using UV detection at 210 nm. Repeatability relative standard deviations (RSDr) ranged from 0.64–3.0% for EP and 2.0–6.6% for PS, excluding the high protein drink mix. Reproducibility relative standard deviations (RSDR) ranged from 2.1–6.6% for EP and 9.0–11.4% for PS, excluding the high protein drink mix. Recoveries ranged from 84.7–87.2% for EP and 84.6–98.2% for PS. The data developed for the minor alkaloids are more variable with generally unsatisfactory HORRATS(i.e., >2). However, since these alkaloids generally add little to the total alkaloid content of the products, the method gives satisfactory results in measuring total alkaloid content (RSDr 0.85–3.13%; RSDR 2.03–10.97%, HORRAT 0.69–3

  2. Ovarian follicle development in the laying hen is accompanied by divergent changes in inhibin A, inhibin B, activin A and follistatin production in granulosa and theca layers.

    PubMed

    Lovell, T M; Gladwell, R T; Groome, N P; Knight, P G

    2003-04-01

    To study the potential involvement of inhibin A (inhA), inhibin B (inhB), activin A (actA) and follistatin (FS) in the recruitment of follicles into the preovulatory hierarchy, growing follicles (ranging from 1 mm to the largest designated F1) and the three most recent postovulatory follicles (POFs) were recovered from laying hens (n=11). With the exception of <4 mm follicles and POFs, follicle walls were dissected into separate granulosa (G) and theca (T) layers before extraction. Contents of inhA, inhB, actA and FS in tissue extracts were assayed using specific two-site ELISAs and results are expressed per mg DNA. InhB content of both G and T followed a similar developmental pattern, although the content was >4-fold higher in G than in T at all stages. InhB content was very low in follicles <4 mm but increased ~50-fold (P<0.0001) to peak in 7-9 mm follicles, before falling steadily as follicles entered and moved up the follicular hierarchy (40-fold; 8 mm vs F2). In stark contrast, inhA remained very low in prehierarchical follicles (< or =9 mm) but then increased progressively as follicles moved up the preovulatory hierarchy to peak in F1 (approximately 100-fold increase; P<0.0001); In F1 >97% of inhA was confined to the G layer whereas in 5-9 mm follicles inhA was only detected in the T layer. Both inhA and inhB contents of POFs were significantly reduced compared with F1. Follicular actA was mainly confined to the T layer although detectable levels were present in G from 9 mm; actA was low between 1 and 9 mm but increased sharply as follicles entered the preovulatory hierarchy (approximately 6-fold higher in F4; P<0.0001); levels then fell approximately 2-fold as the follicle progressed to F1. Like actA, FS predominated in the T although significant amounts were also present in the G of prehierarchical follicles (4-9 mm), in contrast to actA, which was absent from the G. The FS content of T rose approximately 3-fold from 6 mm to a plateau which was sustained

  3. A Short History of Medical Informatics in Bosnia and Herzegovina

    PubMed Central

    Masic, Izet

    2014-01-01

    The health informatics profession in Bosnia and Herzegovina has relatively long history. Thirty five years from the introduction of the first automatic manipulation of data, thirty years from the establishment of Society for Medical Informatics BiH, twenty years from the establishment of the Scientific journal “Acta Informatica Medica (Acta Inform Med”, indexed in PubMed, PubMed Central Scopus, Embase, etc.), twenty years on from the establishment of the first Cathedra for Medical Informatics on Biomedical Faculties in Bosnia and Herzegovina, ten years on from the introduction of the method of “Distance learning” in medical curriculum. The author of this article is eager to mark the importance of the above mentioned Anniversaries in the development of Health informatics in Bosnia and Herzegovina and have attempted, very briefly, to present the most significant events and persons with essential roles throughout this period. PMID:24648621

  4. Vibrational frequencies and structural determinations of di-vinyl sulfone

    NASA Astrophysics Data System (ADS)

    Ellzy, Michael W.; Jensen, James O.; Kay, Jack G.

    2003-03-01

    We present a detailed analysis of the structure and infrared spectra of di-vinyl sulfone. The vibrational frequencies of the di-vinyl sulfone molecule were analyzed using standard quantum chemical techniques. Frequencies were calculated at the MP2 and DFT levels of theory using the standard 6-311G* basis set. The structural transformation of the chemical agent bis(2-chloroehtyl) sulfide (HD, mustard gas) and the related symmetry to a previously study compounds [Spectrochim. Acta Part A 55 (1999) 121; Spectrochim. Acta Part A 57 (2001) 2417] makes the symmetry of the di-vinyl sulfone molecule an interesting candidate for study. The molecule exists normally in a C2 configuration. High-energy forms of di-vinyl sulfone with CS and C1 symmetries also exist.

  5. IDAS: a Windows based software package for cluster analysis

    NASA Astrophysics Data System (ADS)

    Bondarenko, Igor; Treiger, Boris; Van Grieken, René; Van Espen, Pierre

    1996-03-01

    This article is an electronic publication in Spectrochimica Acta Electronica (SAE), the electronic section of Spectrochimica Acta Part B (SAB). The hardcopy text, comprising the main article and one appendix, is accompanied by two installation diskettes with the software package and data files. The main article discusses the chemometric aspects of the package and explains its purpose. The IDAS software package combines three cluster analysis methods (hierarchical, non-hierarchical and fuzzy) and runs under MS Windows. Modified algorithms for non-hierarchical and fuzzy clusterings are described. The interpretation of the clustering results is facilitated by the extensive use of different types of graph. New approaches to the graphical representation of the results of fuzzy clustering are proposed. Two data sets, the Iris data by Fisher and a data set on the chemical composition of tea, are used to demonstrate the capabilities of the software.

  6. A short history of medical informatics in bosnia and herzegovina.

    PubMed

    Masic, Izet

    2014-02-01

    The health informatics profession in Bosnia and Herzegovina has relatively long history. Thirty five years from the introduction of the first automatic manipulation of data, thirty years from the establishment of Society for Medical Informatics BiH, twenty years from the establishment of the Scientific journal "Acta Informatica Medica (Acta Inform Med", indexed in PubMed, PubMed Central Scopus, Embase, etc.), twenty years on from the establishment of the first Cathedra for Medical Informatics on Biomedical Faculties in Bosnia and Herzegovina, ten years on from the introduction of the method of "Distance learning" in medical curriculum. The author of this article is eager to mark the importance of the above mentioned Anniversaries in the development of Health informatics in Bosnia and Herzegovina and have attempted, very briefly, to present the most significant events and persons with essential roles throughout this period.

  7. National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions

    ClinicalTrials.gov

    2016-12-19

    Marfan Syndrome; Turner Syndrome; Ehlers-Danlos Syndrome; Loeys-Dietz Syndrome; FBN1, TGFBR1, TGFBR2, ACTA2 or MYH11 Genetic Mutation; Bicuspid Aortic Valve Without Known Family History; Bicuspid Aortic Valve With Family History; Bicuspid Aortic Valve With Coarctation; Familial Thoracic Aortic Aneurysm and Dissections; Shprintzen-Goldberg Syndrome; Other Aneur/Diss of Thoracic Aorta Not Due to Trauma, <50yo; Other Congenital Heart Disease

  8. Thin film adhesion by nanoindentation-induced superlayers. Final report

    SciTech Connect

    Gerberich, William W.; Volinsky, A.A.

    2001-06-01

    This work has analyzed the key variables of indentation tip radius, contact radius, delamination radius, residual stress and superlayer/film/interlayer properties on nanoindentation measurements of adhesion. The goal to connect practical works of adhesion for very thin films to true works of adhesion has been achieved. A review of this work titled ''Interfacial toughness measurements of thin metal films,'' which has been submitted to Acta Materialia, is included.

  9. Collaborative Research and Development (CR&D) III Task Order 0090: Image Processing Framework: From Acquisition and Analysis to Archival Storage

    DTIC Science & Technology

    2013-05-01

    loy in three and two dimensions using the Saltykov method .’ ’ Scripta Materialia. Acta Materialia Inc., 66(8), 554-557. 15 Approved for public...images and data. 15. SUBJECT TERMS DREAM3D, Finite Element Method (FEM), Integrated Computational Materials Science (ICME), Graphical Interface...Finite E lement Method algorithms. data acqui sition sensitivity studi es and linking material properties to material structure. T he software is s

  10. Prognosis of Long-Term Load-Bearing Capability in Aerospace Structures: Quantification of Microstructurally Short Crack Growth

    DTIC Science & Technology

    2013-07-31

    grain size distributions in a Ni-based superalloy in three and two dimensions using the Saltykov method .” Scripta Materialia, Acta Materialia Inc., 66...Ni-based superalloy in three and two dimensions using the Saltykov method .” Scripta Materialia, 66(8):554–557. ...follows, and as input for the elastic FFT simulation. The spectral method is an alternative to finite element modeling, used in this instance

  11. Antibodies to Liposomes, Phospholipids, and Cholesterol, Implications for Autoimmunity, Atherosclerosis and Aging

    DTIC Science & Technology

    1990-01-01

    bromelain , the autoantibodies recognize the con- figuration of phosphatidyicholine in the membranes." In summary, autoantibodies to lipids and lipid...Cox, JO, Hardy, SJ (1985). Autoantibodies against mouse bromelain -modified RBC are specifically inhibited by a common membrane phospholipid...Biophys Acta 903:265-272. Fujiwara M, Akiyama, Y (1980). LPS-induced autoantibody response. I. Ontogenic development of PFC response to bromelain

  12. Targeting Neuroendocrine Differentiation for Prostate Cancer Radiosensitization

    DTIC Science & Technology

    2014-10-01

    Biophys Acta. 2001;1539:28-43. [24] Bang YJ, Pirnia F, Fang WG, Kang WK, Sartor O, Whitesell L, Ha MJ, Tsokos M, Sheahan MD, Nguyen P, and et al...Executive Committee Member of Purdue University Center for Cancer Research 2013- Member of Big Ten Cancer Research Consortium (BTRC) GU Clinical...cancer P a g e | 9 09/08/10 Place: Purdue University BIG Symposium Title: Fluorescence complementation: An emerging tool for

  13. Clinical Microbiology Reviews. Volume 2, April 1989 Supplement. Perspectives on Pathogenic Neisseriae

    DTIC Science & Technology

    1989-04-01

    11. Elkins, C., H. C. Wilde , C. Farrell, and R. Rest. 1988. The role a model of isolated cerebral capillaries from the rat brain, of PHi outer...recovered MOLECULAR BIOLOGY AND EVOLUTION OF in the Netherlands (74). These isolates carried cryptic (4.2- IP-LACTANIASE PLASMIDS IN kb) and transfer (39.2...goniorrlioeoe isolated in Canada 1976-1984: evolution strains of V\\eiseriu monorrliocae. Acta Pathol. Microbiol. Im- of new auxotypes and (-lactamase-encoding

  14. Ultra-high Strength Nanostructured Mg

    DTIC Science & Technology

    2014-03-31

    27709-2211 Nanostructured Mg and Mg alloys, Mg metallic glass, Cryomilling, Powder consolidation, Spark plasma sintering , Deformation mechanisms REPORT...mechanically milled powder and high pressure on spark plasma sintering of Mg-Cu-Gd metallic glasses; (9) microstructure and mechanical behavior of Mg-10Li-3Al...pressure on spark plasma sintering of Mg– Cu–Gd metallic glasses, Acta Materialia , (07 2013): 4414. doi: Baolong Zheng, Ying Li, Weizong Xu

  15. Prostaglandin E2 Regulation of Chondrocyte Proliferation and Differentiation

    DTIC Science & Technology

    1994-05-01

    increases bone prostaglandin E. Effect of acetylsalicylic acid on disuse osteoporosis studied in dogs. Acta Orthopaedica Scandinavica, 62:238-243. 121...bovine serum, 1% antibiotics, and 50 pg/ml ascorbic acid in 100% humidity at 37oC. Prostaglandin E2 was added to confluent, fourth passage cultures... acid from membrane phospholipids. This, in turn, may lead to the formation of prostaglandins, thromboxanes and prostacyclins through the metabolism of

  16. MICROMECHANICS AND MICROSTRUCTURE EVOLUTION: Modeling, Simulation and Experiments. Held in Madrid, Spain on 12-16 September 2005

    DTIC Science & Technology

    2006-10-30

    hardening–softening curves for ferritic X10CrAl24 steel in constant plastic strain amplitude cycling (the dotted curve separates the initial region before...stress–strain curve for ferritic X10CrAl24 steel. 3432 M. Petrenec et al. / Acta Materialia 54 (2006) 3429–3443of all specimens. Two different regimes...TITLE AND SUBTITLE MICROMECHANICS AND MICROSTRUCTURE EVOLUTION: Modeling, Simulation and Experiments 5c. PROGRAM ELEMENT NUMBER 5d. PROJECT NUMBER

  17. Micromechanics and Microstructure Evolution: Modeling, Simulation and Experiments. Conference Held in Madrid, Spain, 12-16 Sep 2005

    DTIC Science & Technology

    2006-10-30

    hardening–softening curves for ferritic X10CrAl24 steel in constant plastic strain amplitude cycling (the dotted curve separates the initial region before...stress–strain curve for ferritic X10CrAl24 steel. 3432 M. Petrenec et al. / Acta Materialia 54 (2006) 3429–3443of all specimens. Two different regimes...TITLE AND SUBTITLE MICROMECHANICS AND MICROSTRUCTURE EVOLUTION: Modeling, Simulation and Experiments 5c. PROGRAM ELEMENT NUMBER 5d. PROJECT NUMBER

  18. Analytical Transmission Electron Microscopy Studies on Copper-Alumina Interfaces.

    DTIC Science & Technology

    1999-06-01

    examine the data carefully in order to assess the interdependence, if any, between each aspect in relation to the interface microstructure. Finally, there...Eo = accelerating voltage (kV) Z = atomic number A = atomic weight t = thickness (cm) p = density (g cmŗ). b is related to d;, the initial beam...th ng, Proc. 4 Japan International SAMPE Trumble, K. P., Themodynamic Analysis of Aluminate formation at Fe/AhO^ and C14/AI2O3 Interfaces, Acta

  19. Comparison Of The Direct Costs, Length Of Recovery, And Incidence Of Post Operative Anti Emetic Use After Anesthesia Induction With Propofol Or A 1:1 Mixture Of Thiopental And Propofol

    DTIC Science & Technology

    1999-10-01

    in the receptor protein that more fully exposed the receptor site of the other agent. The net result was enhanced GABA function. Further experiments ...anaesthesia: The rationale. European Journal of Anaesthesiology Supplement, 12, p. 5. Anderson, L. R. (1997). The frequency of use and cost of selected...Rhodin, A. (1996). A cost-benefit evaluation of using propofol and alfentanil for a short gynecological procedure. Acta Anaesthesiology Scandinavia, 40

  20. Comparison of the Direct Costs, Length of Recovery, and Incidence of Post Operative Anti-Emetic use After Anesthesia Induction with Propofol or a 1:1 Mixture of Thiopental and Propofol

    DTIC Science & Technology

    1999-10-01

    other agent. The net result was enhanced GABA function. Further experiments need to be done to confirm this. Propofol and midazolam (a...REFERENCES Amrein, R., Hetzel, W., & Allen, S. R. (1995). Co-induction of anaesthesia: The rationale. European Journal of Anaesthesiology Supplement...alfentanil for a short gynecological procedure. Acta Anaesthesiology Scandinavia, 40(4), 416-420. 1:1 Mixture 47 Gan, T.J., Ginsberg, B., Grant, A.P

  1. A Comparison of Intrathecal and Epidural Analgesia and Its Effect on Length of Labor

    DTIC Science & Technology

    2013-01-31

    meperidine > codeine. Their experiments indicated that the analgesic effects of systemically administered narcotics is in part mediated by the...explanation is that subjects who experience prolonged, painful labor may be more likely to ask for pain control with regional analgesia. Thus creating...reference to the use of different local anesthetic agents. Acta Anaesthesiology Scandinavia. 23, 519-529. Wood, C, Huig-Ng, K., & Hounslow, D. (1973). The

  2. The Compressive Failure of Aluminum Nitride Considered as a Model Advanced Ceramic

    DTIC Science & Technology

    2012-06-01

    and fragmentation of hot-pressed silicon carbide under uniaxial compression. Acta Materialia 52 (2), 355–367. Xia, Q., Xia, H., Ruoff, A.L., 1993...Orphal et al., 1996) both as a standalone material and as part of ceramic composites (particularly with SiC ). Much of the literature on bulk...compression experiments. Tungsten carbide platens jacketed by the Ti-6Al-4V titanium alloy were used to protect the loading surfaces of the testing

  3. Status Report on Image Information Systems and Image Data Base Technology

    DTIC Science & Technology

    1989-12-01

    1.6] R. Bayer and E. McCreight, Organization and Maintenance of Large Ordered Indexes, Acta Informatica , Vol. 1, No. 3, pp 173-189, 1972. [1.7] N...There are many examples, GEOVISION, ARC-INFO, a VAR (Value Added Reseller) is FSTI ( Forensic Science Technology International). (See Chapter 4...author is uncertain whether it will find a permanent place in public reading rooms or merely be a tool for library staff. Forensic Science Technology

  4. Superresolved Imaging Using the Hartley Transform and a Hemispherical Object Space

    DTIC Science & Technology

    1988-12-01

    in the far field is a Bessel function - the intensity being later called an Airy pattern (6:419). In 1896, Lord John William Strutt Rayleigh ...April 1968). 13. Walker John G. "Optical Imaging with Resolution Exceeding the Rayleigh Criterion," Optica ACTA, 30: 1197-1202 (1983). 14. Joyce...for challenging my work; Bruce Hornsby, Pink Floyd and Rush for inspiration; and John T. Kelly, my father, for always asking me "Why?". Aoesifoln d/or

  5. A Morphofunctional Study on the Effect of Cytochalasin B on Intestinal Water Transport.

    DTIC Science & Technology

    1986-05-10

    Topic Category Selection hydrochloride . c. Signature Block for Member’s Signature d. Check Presentation Preference Box Each Abstract Form submitted...1999: 4-(2-isopropylamino-I-hydroxyethyl) methanesulfonanilide b. Topic Category Selection hydrochloride . c. Signature Block for Member’s Signature d...intestinal glyco- protein incorporation of 01-14 ) Glucosamine in vitro. Biochim Biophys Acta 261:353. Moe H (1955). On goblet cells, especially of

  6. Isotopic studies of planetary and nuclear materials: A scientific tribute to Ian Douglass Hutcheon (1947-2015)

    NASA Astrophysics Data System (ADS)

    Huss, Gary R.

    2017-03-01

    This issue of Geochimica et Cosmochimica Acta is a scientific tribute to Dr. Ian D. Hutcheon (Fig. 1), who passed away on March 26th, 2015. Ian was a pioneer in the fields of isotope cosmochemistry and nuclear forensics, a friend and colleague to many of us, and an effective and dedicated mentor to young scientists. His scientific interests were wide-ranging and are reflected in the papers in this issue. Many of the authors worked closely with him over the years.

  7. Ethanol-Drug Metabolic Interactions

    DTIC Science & Technology

    1984-06-13

    increased the rate of SNL or PA acetylation , L (-)carnltine, which may enhance the translocation of AcCoA across the mitochondrial membrane, also...J. Lab. Clin. Med. 76:114-125 (1970) 82. Stranberg, I., Bowman, G., Hassler, L ., and Sjoqvist, F.: Acetylator phenotype in patients with...pyruvate, citrate, and L (-) carnitine in isolated rat liver parenchymal cells. Acta Pharmacol. Toxicol. 50:67-74 (1982) 150. Sinclair, J.F., Smith, L

  8. Temporal Subtraction of Digital Breast Tomosynthesis Images for Improved Mass Detection

    DTIC Science & Technology

    2007-10-01

    Hoeschen, U. Fill, M. Zankl, et al., "A High-Resolution Voxel Phantom of the Breast for Dose Calculations in Mammography," Radiation Protection ...34, Acta radiologica 41 (1), 52 (2000). 11 M.P. Callaway, C.R.M. Boggis, S.A. Astley, and I. Hutt, "The influence of previous films on screening...properties of digital mammograms using a computer simulation", Radiation Protection Dosimetry 114, 395 (2005). 75 P. Bakic, M. Albert, D. Brzakovic, and A

  9. Computer Program for Analysis of High Speed, Single Row, Angular Contact, Spherical Roller Bearing, SASHBEAN. Volume 1. User’s Guide

    DTIC Science & Technology

    1993-09-01

    actual fatigue test data for bearings manufactured from "Through Hard- ened" SAE 52100 steel. As per Palmgren [10], for conmmonly used bearing steels...and Palmgren , A., "Dynamic Capacity of Rolling Bearings ", ACTA POLYTECHNICA, Mech. Eng. Ser. 1, No. 3, Vol. 7, 1947. 8. Lundberg, G., and Palmgren , A...Mobil Technical Publications, 1981. 10. Palmgren , A. "Ball and Roller Bearing Engineering", Second Edition, Translated by Palmgren , G., and Ruley, B

  10. Molecular Design and Synthesis of New Noncrystalline Solids

    DTIC Science & Technology

    1981-06-01

    P. Luongo, Thermochimica Acta, S, 141 (1974). 3. Lina Ben-Dor, Eli Fischbein, Israel Feliner and Zvi Kalman, J. Flectrchcm. Soc.: Solid State Science...hexaborides. Increased participation 1121 VVol-II’r fi,Nmn1i itI , i PHY~SICAL. RElVIE\\\\’ L.ETTElRS 29SI ’ I NIIHi 1980 of di electrons in the Y alloy0 may

  11. Assessment of Thermal Dehydration Using the Human Eye: What is the Potential?

    DTIC Science & Technology

    2012-01-01

    pressure during general anaesthesia. Acta Ophthal- mol. 59, 465–475. Institute of Medicine, 2005. Water, Dietary Reference Intakes for Water, Sodium...restriction were reflected in increases in Tosm (Fig. 4) (Fortes et al., 2011). In addition, decreases in plasma osmolality during a fluid intake ...h) during fluid restriction (FR K) and with fluid intake to offset fluid losses (FI J). Values are means and SD (n¼14). HSD indicates Tukey’s honestly

  12. The Modeling of Coupled Electromagnetic-Thermo-Mechanical Laser Interactions and Microstructural Behavior of Energetic Aggregates

    DTIC Science & Technology

    2015-01-01

    Mag. 89 (2009) 2381-402. [12] Rae ,PJ, Hooks,DE, Liu,C, (2006) 293.13th International Symposium on DetonationNorfolk, Virginia, USA. [13] van der...Annapragada,SR, Sun,D, Garimella,SV, Comp. Mater. Sci. 40 (2007) 255-66. [16] Baer,MR, Thermochimica Acta. 384 (2002) 351-67. [17] Brown,EN, Rae ,PJ

  13. Optical applications of von Neumann's alternating-projection theorem.

    PubMed

    Montgomery, W D

    1982-01-01

    The previous work of Gerchberg [Opt. Acta 21, 709 (1974)], Papoulis [IEEE Trans. Circuits Syst. CAS-22, 735 (1975)], Youla [IEEE Trans. Circuits Syst. CAS-25, 694 (1978)], and Stark et al. [J. Opt. Soc. Am. 71, 735 (1981)] on image restoration is presented in a generalized setting. New examples using three projections are given. The method is used to solve the general problem of diffraction by a perfectly conducting plane screen of arbitrary configuration.

  14. The Analytical Exponential Decay Coefficient of the Submarine Light Field.

    DTIC Science & Technology

    1986-01-01

    fundamental optical terms is required. An exact expression can be derived from Schellenberger 14 which is Kd = (a/p)(l - R) + RK (10) UU where R is...Bingham Oceanogr. Coll. 15, 15 (1956). -, 33 *1% * .~.., 5-. .;.~.*4(5%~Ilk 10. G. Schellenberger , "Uber Zusammenhange Zwischen Optischen Parametern Von...Oceanogr. 20, 976 (1975). 14. G. Schellenberger , "Die Form der Raumlichen Strahlungsver- teilung in Gewassern", Acta Hydrophys. 14, 207 (1969). 15. A

  15. Meeting on Solute/Solvent Interactions Held in Aberdeen Proving Ground, Maryland on May 29-30, 1991

    DTIC Science & Technology

    1992-01-01

    J. Taylor, Tetrahedxon Letters, 29, 1587 (1988). 6. G. M. Brown & 0. A. W. Strydom, Acta Crystallogr, Sewt. B 30,801 (1974). 7. P. Marsh & D. E...APPENDIX 3 ORGANIZATIONS OF AUTHORS IN THESE PROCEEDINGS Central Michigan University 49 Instituto de Quimica Fisica 33 La Sierra University, Riverside 71...Aberdeen Proving Gd, MD Joxe-Luis Abbud Christopher Cramer Instituto de Quimica Fisica SMCCR-RSP-C "Rocasolano" U.S. Army Chemical RD&E Center Conajo

  16. Electrosorptive Detection of Simple Organic Compounds in Liquid Chromatography.

    DTIC Science & Technology

    1987-09-30

    Jehring , Elektrosorpelonsanalyse mit der Wechselstrompolarographle, Akademie-Verlag, Berlin, 1974. 3. F. G. Banica, A. Sadoveanu and C. Patroescu...13. 30. H. Jehring , op. cit., Ch. 11. 31. T. Raxnstad and M. J. Weaver, Anal. Chim. Acta, in press. 32. T. Ramstad and M. J. Weaver, submitted for...Comprehensive Treatise of Electrochemistry, Plenum, New York, 1980, Vol. 1, Ch. 8. 41. H. Jehring , op. cit., Ch. 10. 24 42. Ibid., Cbs. 6 and 10. 43

  17. MM&T: Bibliography on Optical Testing with Appendix.

    DTIC Science & Technology

    1982-02-26

    I963-A ITI to TECHNICAL REPORT RH-CR-82-6’.-4 MM&T: BIBLIOGRAPHY ON OPTICAL TESTING WITH APPENDIX A. Comejo-Rodriguez Apdo..Postal 216 Puebla , Puebla ...15 Refs.). Descriptors: LENSES; OPTICAL TESTING; INTERFEROMETERS; LIGHT REFRACTION; VISION Identifiers: TALBOT INTERFEROMETERS; MOIRE FRINGES; LENS...here described. MARTIN, S. "INFLUENCE OF SURFACE DEFECTS ON THE GLARE CHARACTERISTICS OF A NIGHT VISION SYSTEM WITH REFRACTIVE OPTICS" Opt. Acta, 25

  18. Evaluation of the Erythrocyte Malondialdehyde (MDA) Release Assay.

    DTIC Science & Technology

    1987-01-01

    a functional measure of vitamin E status. Clin Chim Acta 1985;151:169-176. 4. Haddad E, Blankenship J. Short term effect of a low fat diet on plasma...with increased plasma tocopherol accompanying hyperlipemia. Haddad placed hyperlipidemic men on low fat diets and found a decreased plasma tocopherol...Kitagawa et al (73,74). From another perspective, Haddad et al placed hyperlipidemic males on a short-term low fat diet and observed a decrease in the plasma

  19. What Will They Learn? A Survey of Core Requirements at Our Nation's Colleges and Universities. 2011-12

    ERIC Educational Resources Information Center

    Kempson, Lauri; Bako, Tom; Markley, Eric

    2012-01-01

    What does it mean to be a college graduate? One knows about the time and ever-increasing amount of money that a diploma demands. But when it comes down to what matters--the skills and knowledge acquired--what does a college degree mean? That is the question the American Council of Trustees and Alumni (ACTA) answers in this book. Inside one will…

  20. Reduction Pathways of Cyclooctatetraene Iron Tricarbonyl as Examined Using Infrared Spectroelectrochemistry.

    DTIC Science & Technology

    1987-09-25

    Examined using Infrared Spectroelectrochemistry by 00 NM. N. Golovin and M. J. Weaver Prepared for Publication 00 00 in the I- Inorg. Chim. Acta IDTlC 0...Examined using Infrared Spectroelectrochemistry M. N. Golovin and M. J. Weaver* Department of Chemistry Purdue University West Lafayette, Indiana...spectra. Upon reduction to (COT)Fe(CO)3 : these bands are both shifted substantially to lower -19 frequencies, 1890 and 1940 cm 1 (Fig. 2B). These

  1. Controlling the Electrostatic Discharge Ignition Sensitivity of Composite Energetic Materials Using Carbon Nanotube Additives

    DTIC Science & Technology

    2014-08-10

    Michelle L. Pantoya, Michael A. Daniels Se. TASK NUMBER Sf. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAMES AND ADDRESSES 8. PERFORMING ORGANIZATION...of composite energetic materials using carbon nanotube additives Kade H. Poper a, Eric S. Collins a, Michelle L. Pantoya a, *, Michael A. Daniels b a...Thermochim. Acta 451 (1 2) (2006). [2] Chelsea Weir, Michelle L. Pantoya, Michael Daniels , Electrostatic discharge sensitivity and electrical conductivity

  2. Regulation & Development of Membrane Transport Processes.

    DTIC Science & Technology

    1985-05-15

    Laboratory, Oak Ridge, Tennessee DAVID W. PLMPLIN Department of Anatomy, University of Maryland School of Medicine, Baltimore, Maryland MARILYN D. RESH...Muscle 265 Douglas M. Fambrough, Barry A. Wolitzky, and David W. Pumplin Index 283 REGULATION AND DEVELOPMENT OF MEMBRANE TRANSPORT PROCESSES 77, II PART 1...243 (Cell Physiol. 12). C 124-C132. 16. Huang. C. C.. Tsai. C. M.. and Canellakis, E. S. (1973) Bochiom. Biophys. Acta. 332, 59-68. 17. Hume . S. and

  3. Slip Continuity in Explicit Crystal Plasticity Simulations Using Nonlocal Continuum and Semi-discrete Approaches

    DTIC Science & Technology

    2013-01-01

    C. F .; Canova, G. R .; Boulanger, L. Three-Dimensional Modeling of Indent-Induced Plastic Zone at a Mesoscale. Acta Mater. 1998, 46, 6183–6194...Dynamics. Modelling Simul. Mater. Sci. Eng. 2007, 15, 553–595. Arsenlis, A.; Parks, D. M.; Becker, R .; Bulatov, V. On the Evolution of Crystallographic...Dislocation Density in Homogeneously Deforming Crystals. J. Mech. Phys. Solids 2004, 52, 1213–1246. Asaro, R . J. Micromechanics of Crystals and

  4. A Method for the Analysis of Tabun in Multisol Using Gas Chromatographic Flame Photometric Detection

    DTIC Science & Technology

    2006-01-01

    Holmstedt, B. 1951. Synthesis and pharmacology of dimethylamido-ethoxy- hydrolysis as shown by the slow rise over 14 h of the resonance phosphoryl cyanide ...phosphoryl cyanide life at -70’C of GA in Multisol versus GA in saline provides (Tabun). Acta Chim. Scand. 7:306-314. more reliable solutions of this nerve...nerve agent seizures: we are investigating reduced concentrations of ethanol in anticholinergics vs diazepam in soman- intoxicated guinea pigs

  5. Libration Point Orbit Utilization for Tactical Advantage in Communications, Surveillance, and Risk Mitigation

    DTIC Science & Technology

    2014-10-27

    Earth ) as the worst case. Different constellation like four different combinations of two spacecrafts in two different orbits (1 s/c in L3 orbit...2013 Received Paper 4.00 Kathryn Davis, George Born, Eric Butcher. Transfers to Earth –Moon L3 halo orbits, Acta Astronautica, (07 2013): 116. doi... Earth -Moon Libration Point Orbits, 2013 AAS Spaceflight Mechanics Conference. 10-FEB-13, . : , Daero Lee, Eric Butcher, Amit Sanyal. Optimal Mixed

  6. Neutrophilic Iron-Oxidizing "Zetaproteobacteria" and Mild Steel Corrosion in Nearshore Marine Environments

    DTIC Science & Technology

    2011-02-16

    hydrothermal venting , to our knowledge, there has been only one report of a single Zetaproteobacteria sequence found in sediments associ- ated with a fish...formation at mid-ocean ridge hydrothermal vents : Juan de Fuca Ridge. Geochim. Cosmochim. Acta 73:388-403. doi:10.1016/j.gca.2008 09.035. 46. Videla...low 02 concentrations, allowing FeOB to compete (6, 38). In marine habitats, such conditions are known to exist in association with hydrothermal

  7. Different Interfacial Behaviors of N- and C-Terminus Cysteine-Modified Cecropin P1 Chemically Immobilized onto Polymer Surface

    DTIC Science & Technology

    2013-08-06

    Rivas, G.; Cai, X. Screen-printed electrochemical hybridization biosensor for the detection of DNA sequences from the Escherichia coli pathogen...Chicharro, M. DNA electrochemical biosensors for environmental monitoring. A review. Anal. Chim. Acta 1997, 347 (1), 1−8. (8) Song, J.; Cheng, Q.; Zhu, S...research shows the different interaction mechanisms between CP1c and PS-MA and between cCP1 and PS-MA. 1. INTRODUCTION Biosensors have been widely used to

  8. Mechanism(s) of Electricity Production by Shewanella and other Microbes: Understanding and Optimization

    DTIC Science & Technology

    2013-08-23

    Figure 1). This system had multiple inputs for electrodes so that a variety of electrochemical analyses could be done during the experiments...Characterization of electrochemically active bacteria utilizing a high- throughput voltage-based screening assay. Biotechnol Bioeng 102:436-44. 4...Acta 53:3508 - 3515. 16. Manohar, A. K., O. Bretschger, K. Nealson, and F. Mansfeld. 2008. The use of electrochemical impedance spectroscopy (EIS) in

  9. A New Model for the Brittle-to-Ductile Transition Based on a Collective Dislocation Generation Instability: Theory and Experiment

    DTIC Science & Technology

    2007-11-02

    Khantha 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) Univ of Pennsylvania 133 South 36th St ., Suite 300 Philadelphia, PA 19104-3246 9...Khantha, D. P. Pope and V. Vitek, Acta mater. 45, 4687 (1997). 6. C. St . John , Philos. Mag. 32,1193 (1975). 7. H. A. Lipsitt, D. Shechtman and E...Collective Dislocation Generation Instability: Theory and Experiment 1998 5. FUNDING NUMBERS F49620-95-1-0143 6. AUTHOR( S ) V. Vitek, D. P. Pope, M

  10. Computer Vision Research and its Applications to Automated Cartography

    DTIC Science & Technology

    1985-09-01

    of specificity. We will use the notation developed by Carnap [381. We assume that a curve or surface has a precise description that captures all...can use any convenient base and treat entropy as a pure number. The following definition, given by Carnap , has some useful properties: S(D’ ) = Inz...and van Doom, A.J., Photometric invariants related to solid shape, Optica Acta, 1980, vol. 27, no. 7, 981-996. [38] Carnap , R., Two Essays on Entropy

  11. Changes in the Vestibular System with Age: An Abstracted Bibliography,

    DTIC Science & Technology

    1981-04-30

    suffering from otosclerosis REFERENCE: Acta Otolaryng. (Stockh.), 1976, 81, 127-129 SUBJECTS (Number-age): Three groups: 20 females, average age 20 (19-22...20 females, average age 42 (36-50) 60 patients - otosclerosis - average age 42 (18-64) EXPERIMENTAL PROCEDURES: Rotation test (nystagmus threshold...FINDINGS: No differences between the normal groups (young/old) in thresholds of acceleration. Otosclerosis patients had significantly higher thresholds

  12. The Role of Endothelial Cells in Myofiber Differentiation and the Vascularization and Innervation of Bioengineered Muscle Tissue in vivo

    DTIC Science & Technology

    2012-10-08

    Udompanyanan K, Yoo JJ, Nomi M, et al. Angiogenic gene -modified muscle cells for enhancement of tissue formation. Tissue Eng 2005;11:1034e44. [10] Saik JE...glycol) hydrogels. Acta Biomater 2011;7:133e43. [11] Delo DM, Eberli D, Williams JK, Andersson KE, Atala A, Soker S. Angiogenic gene modification of...phenotype with adipogenic and osteogenic differentiation potential. Differentiation 2008;76:1031e43. [13] Machingal MA, Corona BT, Walters TJ

  13. Visible Chemical Lasers: Reactions of Metastable Oxygen and the Study of the Red Yoshida Reaction

    DTIC Science & Technology

    1992-05-31

    Lamarre, •, Y. Louvet, M. Nota, D. Pigache, A.J. Ross and M. Setra Europhysics Lett. 12 569 (1990) 13 H.P. Yang, Y. Qin, T.J. Cui, Q.N. Yuan, X.B. Xie ... Q . Zhuang and C.H. Zhang Chem. Phys. Lett. 191 130 (1992) 14 F. Dienstback, F.P. Emmenegger and C.W. Sclapher Hefv. Chem. Acta 60 2460 (1977) Table

  14. Isotopes, an Eight-Year Summary of U.S. Distribution and Utilization

    DTIC Science & Technology

    1955-03-01

    is an increasing need for institutional exhibits, and sends teaching aids on request. radiological safety officers. The AEC is helping to meet the...1 wvith Sniall Ions. Na--24 andl Br--82 Spaces. (1953). S. A. Blersoni andl B1. S. Yalow. Science 12!, NAA 63 Teaching Radiochemnist rv at...llennessy. Acta Med. AA 101 ltow D)evelopnments in Radioactivity Will Scand. 11,2, 228-30(1952). Affect the Teaching of Courses in Pharniaceuti- AA

  15. Molecular Surface Electrostatic Potentials in the Analysis of Non- Hydrogen-Bonding Noncovalent Interactions

    DTIC Science & Technology

    1993-12-27

    preferences (e.g., Brinck , et al., 1993; Kollman, et al., 1975; Leroy, et al., 1976) as well as accepting and donating tendencies (Murray and Politzer, 1991...halogenated methanes ( Brinck , et al., 1992); (b) substituted aromatics, (c) s-tetrazine (Politzer, et al., 1992) and (d) 1,3- bisphenylurea (Murray, et al...and Liquori, A. M. (1956) Acta Cryst., 9, 510. Blackstock, S. C., Lorand, J. P. and Kochi, J. K. (1987) J. Org. Chem., 52, 1451. Brinck , T., Murray, J

  16. Sensory Information Processing

    DTIC Science & Technology

    1975-12-31

    covariance matrix would also be achieved. Prior to loading the covariance matrix to calculate the a(i) coefficients, weighted least squares was used to zero...used in computing the covariance matrix . 1 Synthetic speech generated using the glottal waveform modelling technique described here is...34 Acta Math. 99(1958) pp.265-311 group [12] A.A. Kirrilov "Unitary Representations of Nilpotent Lie groups" Russ. Math. Surveys 17(1962) pp.53

  17. Two Week Oral Dose Range-Finding Toxicity Study of WR242511 in Rats

    DTIC Science & Technology

    1993-07-08

    oximeter (Instrumentation Laboratory Model 282). The assay was performed within one hour of sample collection. The specimens were kept on wet ice prior...were observed. Percent purity of initial WR242511 sample was found to be 99.51%, standard deviation - 0.02%, follow 99.59% ± 0.04%. The assay results...Ciba-Corning 550 Express Clinical Chemistry System Larsen. K. Clin. Chem. Acta, 41, 209, 1972 Total Protein Biuret technique Ciba-Corning 550

  18. Determination of Kinetic Parameters for Thermal Decomposition of Phenolic Ablative Materials by Multiple Heating Rate Method

    DTIC Science & Technology

    1980-07-01

    the ratio method to analyze thermogravimetric data obtained for a urethane polymer. Baer, Hedges, Seader , Jayakar, and Wojcik6 heated samples of...reinforced polymers at heating rates up to 4200°C/min. The data were correlated by a numerical technique developed by Burningham and Seader .7 Friedman...Decomposition Through Thermogravimetric Analysis," Thermochimica Acta, No, 1, (1970), pp. 147-158. 6. A. D. Baer, J. H. Hedges, J. D. Seader , K. M. Jayakar

  19. Identification of Cytoplasmic Proteins Interacting with the Mammary Cell Transforming Domain of Ese-1

    DTIC Science & Technology

    2009-04-01

    and Nordheim, A. 1993. Gene regulation by Ets proteins. Biochim. Biophys. Acta 1155:346-356. 7. Chang, C , Scott, G, Kuo, W, Xiong, X, Suzdaltseva, Y...families, consisting of 27 ETS genes in humans, 26 in mice, 10 in Caenorhabditis elegans and 9 in Drosophila that can be structurally categorized...transcription factor genes in prostate cancer. Science 310, 644–648 40 Chen, C . et al. (2005) ERM is required for transcriptional control of the

  20. AFRRI Reports, Third-Fourth Quarters

    DTIC Science & Technology

    1998-02-01

    Lewis rats because of evidence that VP may regulate secretion of 370 WHITNALL AND SMALLRIDGE TSH from thyrotrope cells in the anterior lobe of the...Metab 50:52-56. 21. Visser TJ, Lambert SWJ. 1981 Regulation of TSH secretion and thyroid function in Cushing’s disease. Acta Endocrinol 96:480- 483. 22...glucocorticoids on thyrotropin secretion . J Clin Invest 48:2096-2103. 28. Brown MR, Hedge GA. 1974 Effects of glucocorticoids on TRH and TSH secretion : dose and

  1. Chinese duo fired for scientific fraud

    NASA Astrophysics Data System (ADS)

    Jiao, Li

    2010-02-01

    A major case of academic fraud in China has led to calls for the country to adopt a new system of academic evaluation that steers away from heavily supporting scientists who publish the most papers. The calls have been made after some 70 papers published by Chinese scientists in Acta Crystallographica Section E were retracted from the journal late last year. The authors acknowledged that their analysis had been fabricated.

  2. Influence of Caffeine on Serum Substrate Changes During Running in Trained and Untrained Individuals,

    DTIC Science & Technology

    1982-04-15

    Frith and J. Karlsson. Effect of physical training on LDH activity and LDH isozyme pattern in human skeletal muscle. Acta Physiol. Scand. 97: 150-157...construed as an official department of the Army position, policy, or decision, unless so designated by other official documentation. Human subjects...UNCLASSIFIED SECURTY CLASIFICATION OF TIS PAG9 (When Date Enter*Q UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGE(hmn Dea Entered) 20. Abstract (continued

  3. On the determination of fiber tilt angles in fiber diffraction.

    PubMed

    Stribeck, Norbert

    2009-01-01

    The common digital method that is used to eliminate the effect of fiber tilt from fiber diffraction patterns is based on an approximation given by Franklin & Gosling [Acta Cryst. (1953), 6, 678-685]. The estimate of the tilt angle is iteratively optimized in the so-called ;Fraser correction'. Building on the fundamental work of Polanyi [Z. Phys. (1921), 7, 149-180], the exact solution is presented.

  4. Joint DoD/DoE Shale Oil Project. Volume 3. Testing of Refined Shale Oil Fuels.

    DTIC Science & Technology

    1983-12-01

    National Laboratory, Oak Ridge, Tennessee 37830. 16-29. Chapter 13, "Comparative Mammalian Genetic Toxicology of Shale Oil Products Assayed Invitro and...34, Analytica Chemica Acta 151, 1983, pp. 349-358. 16-10. Griddings, J. M., "Summary of Research on Coal Liquefaction Product Spills", ORNL /TM-7966, Oak Ridge...Matrix Program", ORNL /TM-7346, Oak Ridge National Laboratory, Oak Ridge, Tennessee, June 1980. 16-14. Gogolak, C. V., "An Evaluation of the Potential

  5. Population Structure of the Primary Malaria Vector in South America, Anopheles darlingi, Using Isozyme, Random Amplified Polymorphic DNA, Internal Transcribed Spacer 2, and Morphologic Markers

    DTIC Science & Technology

    1999-01-01

    derscoring some congruence, in this case, between two dif- ferent molecular markers. Intraspecific variation in the ITS2 region of 21 members of...morphism in the salivary gland chromosomes of Anopheles darlingi. Mosq News 32: 555-565. 29. Tadei WP, Santos JMN, Rabbani MG, 1982. Biologia de ano...Contel EPB, dos Santos JMM, Tadei Wp, 1984. Biologia de Anophelinos Amazonicos. VI. Enzimatica em Anopheles dar- lingi Root (Dipt.: Culicidae). Acta

  6. Dislocation Decorrelation and Relationship to Deformation Microtwins during Creep of a Gamma’ Precipitate Strengthened Ni-based Superalloy

    DTIC Science & Technology

    2011-11-01

    Deformation is highly localized around stress concentrators such as carbides, borides and serrated grain boundaries, which act as sources of a/2h110i...highly localized around stress concentrators such as carbides, borides and serrated grain boundaries, which act as sources of a/2h110i matrix-type...phase at different thicknesses. 7328 R.R. Unocic et al. / Acta Materialia 59 (2011) 7325–7339 the image. A number of carbide and/or boride phases are

  7. Proceedings of the 2nd Annual Conference on Atmospheric Contamination in Confined Spaces, 4 and 5 May 1966

    DTIC Science & Technology

    1966-12-01

    With respect to the ultrastructure of the damages, our findings differ in some points from those of Cedergren et al (ref 14). We could not find any...as compared to the earlier work of Cedergren et al. In the other points our observations agree, particularly with respect to the occurrence of...N. Y. Acad. Sci., Vol 121, p 823, 1965. 145 REFERENCES (CONT’D) 14. Cedergren , B., L. Gyllensten, and J. Wersall, Acta Pediat., Vol 48, p 477, 1959

  8. Center for Advanced Bioengineering for Soldier Survivability

    DTIC Science & Technology

    2013-06-01

    and wettability on the differential response of human osteoblast lineage cells. Acta Biomater. 2013 Apr;9(4):6268-77. doi: 10.1016/j.actbio...Templeman KL, South AB , Gaulding JC, Shoemaker JT, Laplaca MC, Bellamkonda RV, Lyon LA, García AJ. Host response to microgel coatings on neural...Boyan BD, Tannenbaum R, Schwartz Z. The responses to surface wettability gradients induced by chitosan nanofilms on microtextured titanium mediated

  9. The Effects of Hyperbaric Pressure on in vitro Neural Receptors.

    DTIC Science & Technology

    1984-06-01

    induced changes in the molecular organization of a lipid-peptide complex. Polymyxin binding to phosphatidic acid membranes. Biochim. Biophys. Acta 602...nicotinic acetylcholine receptor from rat muscle and eel electroplax were chemically and pharmacologically characterized and then subjected to...nicotinic AChR from rat gastrocnemius muscle , isolated either as a protein or proteoglycolipid, is altered in its binding toward cholinergic agents by

  10. Exposure to transforming growth factor-β1 after basic fibroblast growth factor promotes the fibroblastic differentiation of human periodontal ligament stem/progenitor cell lines.

    PubMed

    Kono, Kiyomi; Maeda, Hidefumi; Fujii, Shinsuke; Tomokiyo, Atsushi; Yamamoto, Naohide; Wada, Naohisa; Monnouchi, Satoshi; Teramatsu, Yoko; Hamano, Sayuri; Koori, Katsuaki; Akamine, Akifumi

    2013-05-01

    Basic fibroblast growth factor (bFGF) is a cytokine that promotes the regeneration of the periodontium, the specialized tissues supporting the teeth. bFGF, does not, however, induce the synthesis of smooth muscle actin alpha 2 (ACTA2), type I collagen (COL1), or COL3, which are principal molecules in periodontal ligament (PDL) tissue, a component of the periodontium. We have suggested the feasibility of using transforming growth factor-β1 (TGFβ1) to induce fibroblastic differentiation of PDL stem/progenitor cells (PDLSCs). Here, we investigated the effect of the subsequent application of TGFβ1 after bFGF (bFGF/TGFβ1) on the differentiation of PDLSCs into fibroblastic cells. We first confirmed the expression of bFGF and TGFβ1 in rat PDL tissue and primary human PDL cells. Receptors for both bFGF and TGFβ1 were expressed in the human PDLSC lines 1-11 and 1-17. Exposure to bFGF for 2 days promoted vascular endothelial growth factor gene and protein expression in both cell lines and down-regulated the expression of ACTA2, COL1, and COL3 mRNA in both cell lines and the gene fibrillin 1 (FBN1) in cell line 1-11 alone. Furthermore, bFGF stimulated cell proliferation of these cell lines and significantly increased the number of cells in phase G2/M in the cell lines. Exposure to TGFβ1 for 2 days induced gene expression of ACTA2 and COL1 in both cell lines and FBN1 in cell line 1-11 alone. BFGF/TGFβ1 treatment significantly up-regulated ACTA2, COL1, and FBN1 expression as compared with the group treated with bFGF alone or the untreated control. This method might thus be useful for accelerating the generation and regeneration of functional periodontium.

  11. Battlefield Acquired Immunogenicity to Metals Affects Orthopedic Implant Outcome

    DTIC Science & Technology

    2013-10-01

    include minor bruising/ hematoma (12.3%), diaphoresis with hypotension (2.6%), syncope (ə%), and cellulitis or phlebitis (ə%). Standard aseptic...PROBLEMS, AND DEVIATIONS Possible adverse events Possible adverse events following phlebotomy include: • Minor bruising/ hematoma (12.3...Lucht U. Metal sensitivity in patients treated for tibial fractures with plates of stainless steel. Acta Orthopedica Scandinavia 1977;48:245-9. Page 11

  12. No Effect of Moderate Hypohydration or Hyperthermia on Anaerobic Exercise Performance

    DTIC Science & Technology

    2006-01-01

    exercise performance using WAnT or similar tests (13,23,30,31) but with possible confounding factors. Webster et al . (30) reported a substantial decline in...release: distribution is unlimited. REFERENCES 1. ARMSTRONG, L. E., C. M. MARESH, J. W. CASTELLANI, et al . Urinary indices of hydration status. Int. J...Sport Nutr. 4: 265 –279, 1994. 2. ASMUSSEN, E., and O. BOJE . Body temperature and capacity for work. Acta. Physiol. Scand. 10:1–22, 1945. 3

  13. Regeneration of the Adult Rat Spinal Cord in Response to Ensheathing Cells and Methylprednisolone

    DTIC Science & Technology

    2002-01-01

    me in academics and research, and also as my friend. I thank Dr. Linda L. Porter, for her continuous efforts on my behalf as the Chairperson of...and Spinal Cord Injury Program. We are grateful to Drs. Barbara S. Bregman and Linda L. Porter for their wonderful suggestions and guidance; to Anna...ES, Pietronigro DD, Seligman ML (1980) The free radical pathology and the microcirculation in the major central nervous system disorders. Acta

  14. Kurzweil's Singularity as a part of Evo-SETI Theory

    NASA Astrophysics Data System (ADS)

    Maccone, Claudio

    2017-03-01

    Ray Kurzweil's famous 2006 book "The Singularity Is Near" predicted that the Singularity (i.e. computers taking over humans) would occur around the year 2045. In this paper we prove that Kurzweil's prediction is in agreement with the "Evo-SETI" (Evolution and SETI)" mathematical model that this author has developed over the last five years in a series of mathematical papers published in both Acta Astronautica and the International Journal of Astrobiology.

  15. Chemistry and Electrochemistry in Lewis Acid and Superacid Ionic Liquids

    DTIC Science & Technology

    1994-04-30

    LEWIS ACID AND SUPERACID IONIC LIQUIDS PRINCIPAL INVESTIGATOR: Dr. Robert A. Osteryoung Department of Chemistry North Carolina State University...Spectroscopic Study of Anthracene in a Mixed Lewis-Bronsted Acid Ambient Temperature Molten Salt System", Electrochim. Acta, 37, 2615-2628 (1992...investigated. In acidic melts, electrochemical oxidation of anthracene produces a cation radical which exhibits stability similar to that found in "Msuperdry

  16. Triclinic polymorph of 4-[4-(4-formyl-phen-oxy)but-oxy]benzaldehyde.

    PubMed

    Balić, Tomislav; Marković, Berislav; Balić, Ivana

    2013-01-01

    The title compound, C18H18O4, is a triclinic polymorph of the previously reported monoclinic polymorph [Han & Zhen (2005 ▶). Acta Cryst. E61, o4358-o4359]. In the crystal of the triclinic polymorph, molecules are linked by two pairs of C-H⋯O hydrogen bonds, forming a two-dimensional network parallel to (102), and enclosing loops with graph set motifs of R2(2)(8) and R2(2)(6).

  17. Astrometric and Photometric Data Fusion for Mass and Surface Material Estimation using Refined Bidirectional Reflectance Distribution Functions-Solar Radiation Pressure Model

    DTIC Science & Technology

    2013-09-01

    M. J., “Survey and Chase: A New Method of Observations for the Michigan Orbital DEbris Survey Telescope (MODEST),” Acta Astronautica, Vol. 65, 2009...pp. 103– 111. [4] Jorgensen, K. M., Using Reflectance Spectroscopy to Determine Material Type of Orbital Debris , Ph.D. thesis, University of... Orbital Debris Photometric Properties Derived from Laboratory-Based Measurements,” Proceedings of the Advanced Maui Optical and Space Surveillance

  18. Endogenous 6-Hydroxymelatonin Excretion and Subsequent Risk of Breast Cancer: A Prospective Study

    DTIC Science & Technology

    2005-03-01

    Epidemiologia e Prevenzione 46:359-363; 1991. Bojkowski CJ. Arendt J. Shih MC. Markey SP. Melatonin secretion in humans assessed by measuring its...urinary 6-hydroxymelatonin excretion. Clinica Chimica Acta. 150(3):221-5, 1985. Mawson AR. Breast cancer in female flight attendants. Lancet. 352(9128...expected cases in a dynamic cohort. Epidemiologia e Prevenzione. 18(60): 164-9; 1994. Muti P, Celentano E, Panico S, Berrino F. Measurement of cutaneous

  19. Endogenous 6-Hydroxylmelatonin Excretion and Subsequent Risk of Breast Cancer: A Prospective Study

    DTIC Science & Technology

    2006-03-01

    D, Zarini E. Progettazione di uno studio prospettico con banca biologica. Epidemiologia e Prevenzione 46:359-363; 1991. Bojkowski CJ. Arendt J...melatonin levels and urinary 6-hydroxymelatonin excretion. Clinica Chimica Acta. 150(3):221-5, 1985. Mawson AR. Breast cancer in female flight...computer program to calculate expected cases in a dynamic cohort. Epidemiologia e Prevenzione.18(60):164-9; 1994. Muti P, Celentano E, Panico S

  20. Endogenous 6-Hydroxymelatonin Excretion and Subsequent Risk of Breast Cancer: A Prospective Study

    DTIC Science & Technology

    2008-03-01

    biologica. Epidemiologia e Prevenzione 46:359-363; 1991. 15 Bojkowski CJ. Arendt J. Shih MC. Markey SP. Melatonin secretion in humans assessed by...Danforth DN. Tamarkin L. The correlation between human plasma melatonin levels and urinary 6-hydroxymelatonin excretion. Clinica Chimica Acta. 150(3...women. J Clin Epidemiol 44:1055-60; 1991. Micheli A, Krogh V. A computer program to calculate expected cases in a dynamic cohort. Epidemiologia e

  1. Endogenous 6-Hydroxymelatonin Excretion and Subsequent Risk of Breast Cancer: A Prospective Study

    DTIC Science & Technology

    2007-03-01

    Zarini E. Progettazione di uno studio prospettico con banca biologica. Epidemiologia e Prevenzione 46:359-363; 1991. Bojkowski CJ. Arendt J. Shih...levels and urinary 6-hydroxymelatonin excretion. Clinica Chimica Acta. 150(3):221-5, 1985. Mawson AR. Breast cancer in female flight attendants...program to calculate expected cases in a dynamic cohort. Epidemiologia e Prevenzione.18(60):164-9; 1994. Muti P, Celentano E, Panico S, Berrino F

  2. Present Development and Current Problems about Composite in Our Country

    DTIC Science & Technology

    1989-12-20

    4 papers discuss about fibre - reinforced concrete. Indian authors recommend reinforcing concrete by natural plant fibre . One paper from them suggests...and << Acta Compound Matarial >>, published book << Mechanics of Short Fibre Composite >> and related papers in the amount of more than 40. Abstract...temperature material, cost of composite in civil use, fibre , development of polymer basegroup, interface study, processing technique, damageless flaw

  3. Mechanisms of Laser Induced Reactions in Opaque Heterogeneous Environments

    DTIC Science & Technology

    1993-11-01

    has been used to study triplet state absorption and fluorescence emission of monomers and dimers of acridine orange and other dyes which are shown to...absorption and fluorescence emission of monomers and dimers of acridine orange and other dyes which are shown to aggregate when adsorbed on...State Absorption of Acridine Orange Adsorbed on Microcrystalline Cellulose. Spectrochemica Acta, 1992, 48A, 135-145. F. Diffuse Reflectance Laser

  4. Terbium to Quantum Dot FRET Bioconjugates for Clinical Diagnostics: Influence of Human Plasma on Optical and Assembly Properties

    DTIC Science & Technology

    2011-10-12

    99, 2344-2354. 11. Selvin, P.R. Lanthanide -based resonance energy transfer. IEEE J. Sel. Top. Quant. Electron. 1996, 2, 1077-1087. 12. Van der Meer...Hildebrandt, N.; Ziessel, R.F.; Löhmannsröben, H.G. Lanthanides to quantum dots resonance energy transfer in time-resolved fluoro-immunoassays and...transfer between cadmium telluride nanoparticle and lanthanide (III) chelate in competitive bioaffinity assays of biotin and estradiol. Anal. Chim. Acta

  5. Osteoblast-Derived PTHRP and Breast Cancer Bone Metastasis

    DTIC Science & Technology

    2004-11-01

    hyperparathyroidism were distinct from those of the immunoreactive PTH found in the serum of patients with primary hyperparathyroidism [14, 15]. In...malignant disease without evidence of bone destmction. A case simu- lating acute hyperparathyroidism . Acta Med Scand 175:353-357 9. Gellhom A... Hyperparathyroidism associated with malignant tumors of nonparathyroid origin. Cancer 24: 1004-1011 11. BuckleR (1974) Ectopic ITH syndrome

  6. Entropic Elastomeric Force in Protein Structure/Function.

    DTIC Science & Technology

    1987-07-01

    5175 (1975). (9) J. M . Gosline and J. Rosenbloom, Extracellular Matrix Biochemistry (Else- vier Press, 1984). (10) A. L. Andrady and J. E . Mark...T. L. Trapane, D. W. Urry and C. E . Bugg, J. Am. Chem. Soc. 102, 5502 (1980). (35) C. M . Venkatachalam and 0. W. Urry, Macromolecules 14, 1225 (1981...63) L. M . Barone, 3. Faris, S. I). Chipman, P. Toselli , B. W. Oakes and C. Franzblau, Biochim. qiophys. Acta., 840, 245 (1985). (64) F. L. Hisaw

  7. From deep TLS validation to ensembles of atomic models built from elemental motions. Addenda and corrigendum.

    PubMed

    Urzhumtsev, Alexandre; Afonine, Pavel V; Van Benschoten, Andrew H; Fraser, James S; Adams, Paul D

    2016-09-01

    Researcher feedback has indicated that in Urzhumtsev et al. [(2015) Acta Cryst. D71, 1668-1683] clarification of key parts of the algorithm for interpretation of TLS matrices in terms of elemental atomic motions and corresponding ensembles of atomic models is required. Also, it has been brought to the attention of the authors that the incorrect PDB code was reported for one of test models. These issues are addressed in this article.

  8. Effects of Hemorrhagic Shock on Antioxidant Enzyme Activities

    DTIC Science & Technology

    1989-07-01

    Granger DN: Xanthine oxidase: biochemistry , distribution, and physiology. Acta Physiol Scand Suppl. 548:87-89, 1986. 8. Weiss SJ: Oxygen, ischemia, and...each) INVESTIGATORS Dr. Michael Artman Dr. Alfred H. Merrill, Jr. Dept. of Pediatrics Dept. of Biochemistry Univ. of South Alabama Emory University...20814-5055 Dr. Robert J. Cohen Dr. Benjamin F. Trump Dept. of Biochemistry and Dept. of Pathology Molecular Biology Univ. of Maryland College of

  9. The Analysis of 2-amino-2-thiazoline-4-carboxylic Acid in the Plasma of Smokers and Non-Smokers

    DTIC Science & Technology

    2009-01-01

    Smoking and Tobacco Control Monograph No.7, National Cancer Institute, Bathesda, pp. 59-70. Hartung. R. 1982. Cyanides and nitriles. In: Clayton, G. D...Chromatogr. 3:209- 212. Scherer, G. 2006. Carboxyhemoglobin and thiocyanate as biomarkers of exposure to carbon monoxide and hydrogen cyanide in tobacco ...reprint. 15. SUBJECT TERMS Cyanide , 2-amino-2-thiazoline-4-carboxylic acid, ACTA, biomarker, gas chromatography-mass spectrometry 16. SECURITY

  10. Targeting Histone Abnormality in Triple-Negative Breast Cancer

    DTIC Science & Technology

    2015-08-01

    1985 Medical or other Professional Licensure: State of Maryland 1982 Commonwealth of Pennsylvania 2009 MEMBERSHIPS IN PROFESSIONAL SCIENTIFIC...inhibition of glucocorticoid binding capacity of rat liver nuclei. Biochim. Biophys. Acta 473:200-10, 1976. PMID 181075 2. Kensler TW, Busby WF, Davidson NE...and Wogan GN. Effect of hepatocarcinogens on the binding of glucocorticoid-receptor complex in rat liver nuclei. Cancer Res. 36:4647-51, 1976. PMID

  11. Buckling of Delaminated Long Panels Under Pressure and of Radially-Loaded Stiffened Annular Plates.

    DTIC Science & Technology

    1985-10-01

    Sheinman [7-10]. The governing equations for the nonlinear analysis of imperfect, stiffened, laminated, circular, cylindrical thin shells, subjected to...No. 4, 1985, pp. 529-544. 7. Simi tses, G. J.I Sheinman , I., and Shaw, D., "Stability of Laminated ComposJte Shells Subjected to Uniform Axial... Sheinman , I., "Imperfect, Laminated, Cyl ndri cal Shells in Torsion and Axial Compression", Acta -,Ftronautica, v. 10, No. 5-6, 1983, pp. 395-400

  12. Grain-Structure Development in Heavily Cold-Rolled Alpha-Titanium (Postprint)

    DTIC Science & Technology

    2014-04-01

    H.P. Lee, C. Esling , H.J. Bunge, Textures Microstruct. 7 (1988) 317–337. [10] S. Nourbakhsh, T.D. O’Brien, Mater. Sci. Eng. 100 (1988) 109–114. [11...2010) 4536–4548. [20] Y. Zhong, F. Yin, K. Nagai, J. Mater. Res. 23 (2008) 2954–2966. [21] M.J. Philippe, M. Serghat, P. Van Houtte, C. Esling , Acta

  13. Novel Expressions of Equations of Relative Motion and Control in Keplerian Orbits

    DTIC Science & Technology

    2009-04-01

    spacecraft , and thus prediction and control of relative motion is significantly sensitive to relative orbit modeling errors [9...proposed a continuous feedback controller for rendezvous navigation in elliptical orbit . In this work, the full equations of relative motion (see [9... Rendezvous in Elliptical Orbits ,” Acta Astronautica, Vol. 41, No. 2, July 1997, pp. 95–101. doi:10.1016/S0094-5765(97)00204-X [19] Yu, S., “ Control

  14. The Shock and Vibration Digest. Volume 17, Number 2

    DTIC Science & Technology

    1985-02-01

    Seismicity, Groundwater rium Emanations from Rock Specimens Chemistry , and Groundwater Radon in under Pressure," Acta Seismol. Sin., 2, (2), Southern...The keynote address was given by Colonel The 55th Shock and Vibration Symposium, Craig 0. Schaum , Deputy for Engineering sponsored by the Shock and...It was hosted by the Aeronau- cussed developments at ASD. Colonel tical Systems Division of Wright-Patterson Schaum traced the early developments in

  15. Biomedical Effects of Chemical-Threat-Agent Antidote and Pretreatment Drugs. An Abstracted Bibliography. Volume 1.

    DTIC Science & Technology

    1986-04-01

    and average atropine tissue levels. No correlation existed between pulse rate and plasma levels of atropine. (Cont’d) 10 3. There was no significant...change in blood pressure. 4. Atropine was widely distributed in tissues . Atropine disappears rapidly from the plasma after i.v. administration. INDEX...TITLE: Drug effects on the auditory speech discrimination mechanism : The action of atropine and scopolamine C : Acta Otolaryngologica kStockh), 1964, 58

  16. A note on the neutral stochastic functional differential equation with infinite delay and Poisson jumps in an abstract space

    NASA Astrophysics Data System (ADS)

    Ren, Yong; Chen, Li

    2009-08-01

    In this note, we prove the existence and uniqueness of the solution to neutral stochastic functional differential equation with infinite delay and Poisson jumps in the phase space B with non-Lipschitz coefficients. The known results that appeared in the studies by Ren and Xia [Appl. Math. Comput. 210, 72 (2009); Ren and XiaAppl. Math. Comput. 214, 457 (2009)] and Xu and Hu [Acta Appl. Math. (unpublished)] are generalized and improved. An example is provided to illustrate the theory.

  17. A Combined Isotropic-Kinematic Hardening Model for Large Deformation Metal Plasticity

    DTIC Science & Technology

    1988-12-01

    713C and Waspaloy, ASME Series D, 87, p. 275. 1965 WILSON, D.V., Reversible Work Hardening in Alloys of Cubic Metals, Acta Metallurgica, 13, pp. 807-814...Sum m ary ............................................................ 32 3. Micromodeling of a Particle-Hardened Alloy Using the Finite Element M...in a particle hardened alloy is presented. A finite element model was used to model the effects of the particle-matrix interaction. The results

  18. Liquid Crystal Based Optical Phased Array for Steering Lasers

    DTIC Science & Technology

    2009-10-01

    OPD3 E1 → E2a E2b Fourier T f θ1 θ2 θ r1 r2 Fig. 2.3 Scalar integral approach of three-layer decentered micro-lens array...1987). 38 Robert Guenther, “Modern Optics”, John Wiley & Sons, NY, 345-346 (1990). 39 L. Nikolova, T. Todorov, Optica Acta, vol. 31, pp. 579-588

  19. Wood Anatomy of the Neotropical Sapotaceae. XXV. Ragala

    DTIC Science & Technology

    1981-05-01

    Sapoticeas da Amazonia . Acta Amazonica 4(3):15-16. 7.1C TAB f• icatio By-- - Table 1.--Ragala: Specimens examined and their selected parameters-I Wood Species... WOOD ANATOMY OF THE NEOTROPICAL SAPOTACEAE / XXV. RAGALA RESEARCH PAPER FPL 396 FOREST PRODUCTS LABORATORY FOREST SERVICE U.S. DEPARTMENT OF... wood anatomy supports the separation of Ecclinusa and Rmagala as well as their removal from Chrysophyllum. Ragala is a silica-accumulating genus

  20. The Aorta: Built to Last a Lifetime?

    DTIC Science & Technology

    2007-11-02

    that coronary heart disease [14], stroke [15], hypertension [16] and atherosclerosis [17], are associated with impaired growth and development...in adult life," Lancet, vol. 341, pp. 938-941, 1993. [15] D.J. Barker, "Intrauterine programming of coronary heart disease and stroke," Acta...Abstract-The pulse pressure generated by the heart is determined by the hydraulic input impedance of the circulation which, in turn is governed by

  1. Gangliosides During Tumor Progression in Patients With Prostate Cancer

    DTIC Science & Technology

    2004-07-01

    LSCFM, Thiruverkadu S. Saravanan, Ph.D. and Meena Verma, M.B., B.S., for other technical support. 15 References 1. P. M . Gullino , Prostaglandins and...121-135. 3. G. Alessandri, P. Cornaglia-Ferraris, P. M . Gullino , Angiogenic and angiostatic microenvironment in tumors-role of gangliosides. Acta...Wiegandt (Ed), Glycolipids, Elsevier, Amsterdam, 1985, pp. 199-260. 11. M . L . Freimer, K. McIntosh, R. A. Adams, C. R. Alving, D. B. Drachman

  2. Finite Dimensional Approximation of a Class of Constrained Nonlinear Optimal Control Problems

    DTIC Science & Technology

    1994-03-01

    property for Schr ~ dinger Hanxiltonians, Helvetica Physiea Acta, 52 (1979), pp. 655-670. [13) V. GIRAULT AND P. RAVIART, Finite Element Methods for Navier...involves the von Kirma.n plate equations of nonlinear elasticity, the second the Ginzburg-Landau equations of superconductivity, and the third the...Navier-Stokes equations for incompressible, viscous flows. ’This research was supported by the National Aeronautics and Space Administration under NASA

  3. Tissue Distribution of Exogenously Administered Human Serum Butyrylcholinesterase-Soman Conjugate(HuBuChE-GD) in Guinea Pigs to Predict its Toxicity

    DTIC Science & Technology

    2010-02-01

    deficits by pretreatment with human butyrylcholinesterase in rats.Pharmacol. Biochem. Behav. 46, 889-96. [3] Raveh, L., Grauer , E., Grunwald, J...Ashani, Y., Grunwald, J., Raveh, L., Grauer , E., Brandeis, R., Marcus, D., Papier, Y., Kadar, T., Allon, N., Gilat, E., and Lerer, S. (1993...L.T. (1988). Half-life of plasma cholinesterase, Acta Anaesthesiol. Scand., 32, 266-269. [11] Ashani, Y., Grauer , E., Grunwald, J., Allon, N., and

  4. Medical Surveillance Monthly Report (MSMR). Volume 6, Number 5, May/June 2000

    DTIC Science & Technology

    2000-06-01

    palsy and herpes viruses: to (acyclo)vir or not to (acyclo)vir? J Neur Sci, 1999, 170: 19-23. 7. Peitersen P. Natural history of Bell’s palsy . Acta...U S A C H P P M MSMR Data in the MSMR are provisional, based on reports and other sources of data available to the Army Medical Surveillance Activity...events, active duty soldiers .................................... 6 Bell’s Palsy , US Armed Forces, 1998-1999

  5. A New Therapeutic Strategy for Autosomal Dominant Polycystic Kidney Disease: Activation of AMP Kinase by Metformin

    DTIC Science & Technology

    2011-07-01

    Gattone VH, 2nd, Witzmann FA, Blazer-Yost BL (2009) Structural and functional analyses of liver cysts from the BALB/c-cpk mouse model of polycystic kidney...1047–1051. 38. Doctor RB, et al. (2007) Regulated ion transport in mouse liver cyst epithelial cells. Biochim Biophys Acta 1772:345–354. 39. Gattone...Patients are born with normal kidneys but, over the course of decades, they develop large fluid filled cysts that damage the normal kidney tissue. The

  6. Fabrication and Characterization of Novel Refractory Coatings Using Combinatorial Nanocalorimetry

    DTIC Science & Technology

    2015-07-21

    JM Gregoire, PJ McCluskey, JJ Vlassak, A scanning AC calorimetry technique for the analysis of nano -scale quantities of materials Review of...of Physical Chemistry C 118, 21192 (2014) 8. K Xiao, D Lee, JJ Vlassak, Kinetics of solid-gas reactions characterized by scanning AC nano ...rates from 101 to 104 K/s studied by combining scanning AC and DC nano -calorimetry techniques, Thermochimica Acta 603, 29 (2015) 10. PJ McCluskey, K

  7. Effects of Repeated Traumatic Brain Injuries in a Combat Setting

    DTIC Science & Technology

    2011-12-01

    Koepsell, T. D., Reifler, B. V., van Belle, G., Larson, E. B., et al. (1990). The association between head trauma and Alzheimer’s disease . Am J... Alzheimer’s disease . Neurology, 35(2), 264-267. Moser, R. S., & Schatz, P. (2002). Enduring effects of concussion in youth athletes. Arch Clin Neuropsychol...state in dementia pugilistica recapitulate Alzheimer’s disease . Acta Neuropathol, 101(5), 518-524. Slobounov, S., Cao, C., & Sebastianelli, W. (2009

  8. Genomic profiling of multiple sequentially acquired tumor metastatic sites from an “exceptional responder” lung adenocarcinoma patient reveals extensive genomic heterogeneity and novel somatic variants driving treatment response

    PubMed Central

    Biswas, Romi; Gao, Shaojian; Cultraro, Constance M.; Maity, Tapan K.; Venugopalan, Abhilash; Abdullaev, Zied; Shaytan, Alexey K.; Carter, Corey A.; Thomas, Anish; Rajan, Arun; Song, Young; Pitts, Stephanie; Chen, Kevin; Bass, Sara; Boland, Joseph; Hanada, Ken-Ichi; Chen, Jinqiu; Meltzer, Paul S.; Panchenko, Anna R.; Yang, James C.; Pack, Svetlana; Giaccone, Giuseppe; Schrump, David S.; Khan, Javed; Guha, Udayan

    2016-01-01

    We used next-generation sequencing to identify somatic alterations in multiple metastatic sites from an “exceptional responder” lung adenocarcinoma patient during his 7-yr course of ERBB2-directed therapies. The degree of heterogeneity was unprecedented, with ∼1% similarity between somatic alterations of the lung and lymph nodes. One novel translocation, PLAG1-ACTA2, present in both sites, up-regulated ACTA2 expression. ERBB2, the predominant driver oncogene, was amplified in both sites, more pronounced in the lung, and harbored an L869R mutation in the lymph node. Functional studies showed increased proliferation, migration, metastasis, and resistance to ERBB2-directed therapy because of L869R mutation and increased migration because of ACTA2 overexpression. Within the lung, a nonfunctional CDK12, due to a novel G879V mutation, correlated with down-regulation of DNA damage response genes, causing genomic instability, and sensitivity to chemotherapy. We propose a model whereby a subclone metastasized early from the primary site and evolved independently in lymph nodes. PMID:27900369

  9. Crystal structure and Hirshfeld surface analysis of 1-carb-oxy-2-(3,4-di-hydroxy-phen-yl)ethan-1-aminium chloride 2-ammonio-3-(3,4-di-hydroxy-phen-yl)propano-ate: a new polymorph of l-dopa HCl and isotypic with its bromide counterpart.

    PubMed

    Kathiravan, Perumal; Balakrishnan, Thangavelu; Venkatesan, Perumal; Ramamurthi, Kandasamy; Percino, María Judith; Thamotharan, Subbiah

    2016-11-01

    The title mol-ecular salt, C9H12NO4(+)·Cl(-)·C9H11NO4, is isotypic with that of the bromide counterpart [Kathiravan et al. (2016 ▸). Acta Cryst. E72, 1544-1548]. The title salt is a second monoclinic polymorph of the l-dopa HCl structure reported earlier in the monoclinic space group P21 [Jandacek & Earle (1971 ▸). Acta Cryst. B27, 841-845; Mostad & Rømming (1974 ▸). Acta Chemica Scand. B28, 1161-1168]. In the title compound, monoclinic space group I2, one of the dopa mol-ecules has a positive charge with a protonated α-amino group and the α-carb-oxy-lic acid group uncharged, while the second dopa mol-ecule has a neutral charge, the α-amino group is protonated and the α-carb-oxy-lic acid is deprotonated. In the previously reported form, a single dopa mol-ecule is observed in which the α-amino group is protonated and the α-carb-oxy-lic acid group is uncharged. The invariant and variations of various types of inter-molecular inter-actions present in these two forms of dopa HCl structures are discussed with the aid of two-dimensional fingerprint plots.

  10. Crystal structure and Hirshfeld surface analysis of 1-carb­oxy-2-(3,4-di­hydroxy­phen­yl)ethan-1-aminium chloride 2-ammonio-3-(3,4-di­hydroxy­phen­yl)propano­ate: a new polymorph of l-dopa HCl and isotypic with its bromide counterpart

    PubMed Central

    Kathiravan, Perumal; Balakrishnan, Thangavelu; Venkatesan, Perumal; Ramamurthi, Kandasamy; Percino, María Judith; Thamotharan, Subbiah

    2016-01-01

    The title mol­ecular salt, C9H12NO4 +·Cl−·C9H11NO4, is isotypic with that of the bromide counterpart [Kathiravan et al. (2016 ▸). Acta Cryst. E72, 1544–1548]. The title salt is a second monoclinic polymorph of the l-dopa HCl structure reported earlier in the monoclinic space group P21 [Jandacek & Earle (1971 ▸). Acta Cryst. B27, 841–845; Mostad & Rømming (1974 ▸). Acta Chemica Scand. B28, 1161–1168]. In the title compound, monoclinic space group I2, one of the dopa mol­ecules has a positive charge with a protonated α-amino group and the α-carb­oxy­lic acid group uncharged, while the second dopa mol­ecule has a neutral charge, the α-amino group is protonated and the α-carb­oxy­lic acid is deprotonated. In the previously reported form, a single dopa mol­ecule is observed in which the α-amino group is protonated and the α-carb­oxy­lic acid group is uncharged. The invariant and variations of various types of inter­molecular inter­actions present in these two forms of dopa HCl structures are discussed with the aid of two-dimensional fingerprint plots. PMID:27840723

  11. Determination of Structural and Vibrational Properties of 5-QUINOLINECARBOXALDEHYDE Using Experimental Ft-Ir Ft-Raman Techniques and Theoretical HF and DFT Methods

    NASA Astrophysics Data System (ADS)

    Kumru, Mustafa; Kocademir, Mustafa; Bardakci, Tayyibe

    2013-06-01

    Quinoline derivatives have been used in several pharmaceuticals. They have vital roles in regulating the functions of DNA and cancerous cells. It's necessary to determine the structures and spectroscopic properties of quinoline derivates. In this study, the FT-IR (including mid and far regions) and FT-Raman spectra of 5-quinolinecarboxaldehyde have been investigated. Hartree-Fock (HF) and density functional B3LYP calculations have also been employed with the 6-311++G(d,p) basis set for investigating the structural and spectroscopic properties of the cis and trans conformers of 5-quinolinecarboxaldehyde. Experimental and theoretical results have been compared and the results are in good agreement with each other. Keywords: 5-quinolinecarboxaldehyde; Vibrational Spectroscopy; FT-IR spectra; FT-Raman spectra; Vibrational Modes; HF; DFT [1] V. Kucuk, A. Altun, M. Kumru, Spectrochim. Acta Part A 85(2012)92-98 [2] M. Kumru, V. Kucuk, T. Bardakci, Spectrochim. Acta Part A 90(2012)28-34 [3] M. Kumru, V. Kucuk, M. Kocademir, Spectrochim. Acta Part A, 96 (2012) 242-251 We thank the Turkish Scientific and Technical Research Council (TUBITAK) for their financial support through National Postdoctoral Research Scholarship Programme and Scientific Research Fund of Fatih University under the project number P50011001 G (1457).

  12. Chromite alteration processes within Vourinos ophiolite

    NASA Astrophysics Data System (ADS)

    Grieco, Giovanni; Merlini, Anna

    2012-09-01

    The renewed interest in chromite ore deposits is directly related to the increase in Cr price ruled by international market trends. Chromite, an accessory mineral in peridotites, is considered to be a petrogenetic indicator because its composition reflects the degree of partial melting that the mantle experienced while producing the chromium spinel-bearing rock (Burkhard in Geochim Cosmochim Acta 57:1297-1306, 1993). However, the understanding of chromite alteration and metamorphic modification is still controversial (e.g. Evans and Frost in Geochim Cosmochim Acta 39:959-972, 1975; Burkhard in Geochim Cosmochim Acta 57:1297-1306, 1993; Oze et al. in Am J Sci 304:67-101, 2004). Metamorphic alteration leads to major changes in chromite chemistry and to the growth of secondary phases such as ferritchromite and chlorite. In this study, we investigate the Vourinos complex chromitites (from the mines of Rizo, Aetoraches, Xerolivado and Potamia) with respect to textural and chemical analyses in order to highlight the most important trend of alteration related to chromite transformation. The present study has been partially funded by the Aliakmon project in collaboration between the Public Power Corporation of Greece and Institute of Geology and Mineral Exploration of Kozani.

  13. Retraction statement: Dynamics of Cytochrome C Oxidase Activity in Acute Ischemic Stroke' by Selaković, V.M., Jovanović, M.D., Mihajlović, R.R. and Radenović, L.L.J.

    PubMed

    2016-10-01

    The above article from Acta Neurologica Scandinavica, published online on 7 April 2005 in Wiley Online Library (wileyonlinelibrary.com) and in Volume 111, pp. 329-332, has been retracted by agreement between the journal Editor in Chief, Professor Elinor Ben-Menachem, and John Wiley & Sons Ltd. The article has been retracted because a similar article had previously been published in the Jugoslovenska medicinska biohemija in 2003. The authors presumed that since the journal was no longer existing, they felt the need to re-publish their work in Acta Neuorologica Scandinavica. However, in the consideration of the Journal, this constitutes dual publication. References SelakovićVM, JovanovićMD, MihajlovićR, RadenovićLLJ. Cytochrome c oxidase in patients with acute ischaemic brain disease. Jugoslovenska medicinska biohemija. 2003;22:329-334. SelakovićVM, JovanovićMD, MihajlovićRR, RadenovićLLJ. Dynamics of cytochrome c oxidase activity in acute ischemic stroke. Acta Neurol Scand. 2005;111:329-332.

  14. Interactions of Listeria monocytogenes with mammalian cells during entry and actin-based movement: bacterial factors, cellular ligands and signaling.

    PubMed Central

    Cossart, P; Lecuit, M

    1998-01-01

    Although <50 kb of its 3.3 megabase genome is known, Listeria monocytogenes has received much attention and an impressive amount of data has contributed in raising this bacterium among the best understood intracellular pathogens. The mechanisms that Listeria uses to enter cells, escape from the phagocytic vacuole and spread from one cell to another using an actin-based motility process have been analysed in detail. Several bacterial proteins contributing to these events have been identified, including the invasion proteins internalin A (InlA) and B (InlB), the secreted pore-forming toxin listeriolysin O (LLO) which promotes the escape from the phagocytic vacuole, and the surface protein ActA which is required for actin polymerization and bacterial movement. While LLO and ActA are critical for the infectious process and are not redundant with other listerial proteins, the precise role of InlA and InlB in vivo remains unclear. How InlA, InlB, LLO or ActA interact with the mammalian cells is beginning to be deciphered. The picture that emerges is that this bacterium uses general strategies also used by other invasive bacteria but has evolved a panel of specific tools and tricks to exploit mammalian cell functions. Their study may lead to a better understanding of important questions in cell biology such as ligand receptor signalling and dynamics of actin polymerization in mammalian cells. PMID:9669997

  15. Next generation receivers for the submillimeter array

    NASA Astrophysics Data System (ADS)

    Grimes, Paul; Blundell, Ray; Paine, Scott; Tong, C.-Y. Edward; Zeng, Lingzhen

    2016-07-01

    The Submillimeter Array (SMA) is an 8-element mm/sub-mm interferometer on the summit of Maunakea, Hawaii that is operated jointly by the Smithsonian Astrophysical Observatory (SAO) and the Academia Sinica Institute of Astronomy and Astrophysics (ASIAA). After nearly 13 years of operation, we are undertaking a major upgrade of the array's cryogenics, receivers and other systems that will enhance the science capabilities of the array and replace components reaching end-of-life. Here we describe the new receivers, containing dual-polarization, ultra-wideband SIS mixers operating at 230 and 345 GHz, the new ultra-wideband IF signal transport and correlator system, and the enhanced observing capabilities that will be enabled by this upgrade.

  16. Status of the Transneptunian Automated Occultation Survey (TAOS II)

    NASA Astrophysics Data System (ADS)

    Reyes-Ruiz, Mauricio

    2014-11-01

    TAOS II is a next generation occultation survey with the goal of measuring the size distribution of the small objects (diameters between 0.5 and 30 km) in the Kuiper Belt. The project is a collaboration between the Academia Sinica Institute of Astronomy and Astrophysics, the Universidad Nacional Autonoma de Mexico, and the Harvard-Smithsonian Center for Astrophysics, The survey will operate three 1.3 m telescopes at San Pedro Martir Observatory in Baja California, Mexico. Each telescope will be equipped with a custom camera comprising a focal plane array of CMOS imagers. Each camera will be capable of reading out image data from 10,000 stars at a cadence of 20 Hz. All telescopes will monitor the same set of stars simultaneously to search for coincident occultation events while minimizing the false positive rate. This poster describes the project and reports on the progress of the development of the survey infrastructure.

  17. A mysterious blood pressure increase in a drilling Naval reservist.

    PubMed

    Wettach, George E; Falvey, Shelley G

    2002-06-01

    This is a case report of a reservist who presented for a physical examination with hypertension. It was discovered that the reservist was unknowingly taking large doses of Ephedra sinica, or ma huang, a Chinese herbal supplement, for body-building. One of the ingredients in ma huang is ephedrine, an active alpha- and beta-adrenergic stimulant that produces increases in heart rate, blood pressure, and cardiac output. Ma huang has been reported to cause hypertension, hepatitis, nephrolithiasis, and sudden death in healthy, normotensive people. Ma huang will produce a positive urinary drug screen for stimulants and can be a drug of abuse. A recommendation is made to screen for dangerous supplement use before physical readiness training and to stop the supplement for 1 month before beginning any exercise program.

  18. A jump-start for astronomy education in Taiwan

    NASA Astrophysics Data System (ADS)

    Chen, Wen-Ping

    Spurred by the leaping developments of research activities (SMA, TAOS, AMIBA), Taiwan is catching up its education in astronomy in virtually all aspects. The first astronomy research institute was established by the Academia Sinica about 10 years ago, which catalyzed within 2 years the first graduate school of astronomy, as well as an elaborative astronomy museum. Since then the astronomy education at all levels, from colleges to primary schools, has been booming. More than a dozen universities are offering astronomy courses, and two more graduate schools will soon be instituted. Textbooks get written, and books on popular sciences, either translated or composed by local authors, have mushroomed on the market. I will outline these ongoing activities along with plans in the horizon.

  19. Progress of the array of microwave background anisotropy (AMiBA)

    NASA Astrophysics Data System (ADS)

    Raffin, Philippe; Koch, Patrick; Huang, Yau-De; Chang, Chia-Hao; Chang, Joshua; Chen, Ming-Tang; Chen, Ke-Yung; Ho, Paul T. P.; Huang, Chih-Wie; Ibañez Roman, Fabiola; Jiang, Homin; Kesteven, Michael; Lin, Kai-Yang; Liu, Guo-Chin; Nishioka, Hiroaki; Umetsu, Keiichi

    2006-06-01

    The Academia Sinica, Institute for Astronomy and Astrophysics (ASIAA) is installing the AMiBA interferometric array telescope at the Mauna Loa Observatory, Hawaii. The 6-meter carbon fiber fully steerable platform is mounted on the Hexapod Mount. After integration and equipment with dummy weights, the platform has been measured by photogrammetry to verify its behavior predicted by Finite Element Analysis. The Hexapod servo control is now operational and equipment of the platform with the initial 7 60-cm dishes, the correlator and electronics is underway. Pointing has started with the aid of the optical telescope. We present the status of the telescope after the servo and initial pointing tests have been carried out. We also present the results of platform measurements by photogrammetry.

  20. The International Symposium on Grids and Clouds

    NASA Astrophysics Data System (ADS)

    The International Symposium on Grids and Clouds (ISGC) 2012 will be held at Academia Sinica in Taipei from 26 February to 2 March 2012, with co-located events and workshops. The conference is hosted by the Academia Sinica Grid Computing Centre (ASGC). 2012 is the decennium anniversary of the ISGC which over the last decade has tracked the convergence, collaboration and innovation of individual researchers across the Asia Pacific region to a coherent community. With the continuous support and dedication from the delegates, ISGC has provided the primary international distributed computing platform where distinguished researchers and collaboration partners from around the world share their knowledge and experiences. The last decade has seen the wide-scale emergence of e-Infrastructure as a critical asset for the modern e-Scientist. The emergence of large-scale research infrastructures and instruments that has produced a torrent of electronic data is forcing a generational change in the scientific process and the mechanisms used to analyse the resulting data deluge. No longer can the processing of these vast amounts of data and production of relevant scientific results be undertaken by a single scientist. Virtual Research Communities that span organisations around the world, through an integrated digital infrastructure that connects the trust and administrative domains of multiple resource providers, have become critical in supporting these analyses. Topics covered in ISGC 2012 include: High Energy Physics, Biomedicine & Life Sciences, Earth Science, Environmental Changes and Natural Disaster Mitigation, Humanities & Social Sciences, Operations & Management, Middleware & Interoperability, Security and Networking, Infrastructure Clouds & Virtualisation, Business Models & Sustainability, Data Management, Distributed Volunteer & Desktop Grid Computing, High Throughput Computing, and High Performance, Manycore & GPU Computing.

  1. "DUST BUSTER" - A Single Photon Ionization TOF MS for Cometary Dusts

    NASA Technical Reports Server (NTRS)

    Chen, C.-Y.; Calaway, W. F.; Lee, Typhoon; Moore, J. F.; Pellin, M. J.; Veryovkin, I. V.

    2003-01-01

    It is hard to predict the properties and composition of dust that will be returned by STARDUST from WED- 2. The most interesting but challenging case would be grains, pg to fg in weight, each carrying its own isotopic signature characteristic of its source zones in a variety of stars. How do we extract the maximum amount of science from such grains? Clearly, the best that can be accomplished is to measure every atom in each grain.Academia Sinica and Argonne National Laboratory (ANL) have entered into a collaboration to develop a SPI TOF MS instrument for analysis of stardust grains. A new instrument will be built at Academia Sinica based on the new TOF mass spectrometer design developed, built and operating at ANL. The instrument is intended for SPI TOF MS analysis of elements from Ca to Cu plus Li after first using SIMS to measure H, C, N, 0, Si, and S. There are still technical challenges facing the technique. We will need to improve submicrometer sample handling, avoid the effects of space charge, and increase the Mamie range of the detector. The most difficult obstacle to overcome may be the fact that the flux density of present high repetition rate, WV lasers is below the level needed to ensure full ionization (saturation) in the source region, which must be several mm in size to achieve the high useful yield needed for analysis of small stardust grains. A potential breakthrough effort is to exploit the novel free electron laser being pioneered at ANL. In principle, this FEL can reach ionization saturation and is tunable up to photon energies of 25 eV, which is higher than the ionization potential of any element.

  2. A spectral graph theoretic approach to quantification and calibration of collective morphological differences in cell images

    PubMed Central

    Lin, Yu-Shi; Lin, Chung-Chih; Tsai, Yuh-Show; Ku, Tien-Chuan; Huang, Yi-Hung; Hsu, Chun-Nan

    2010-01-01

    Motivation: High-throughput image-based assay technologies can rapidly produce a large number of cell images for drug screening, but data analysis is still a major bottleneck that limits their utility. Quantifying a wide variety of morphological differences observed in cell images under different drug influences is still a challenging task because the result can be highly sensitive to sampling and noise. Results: We propose a graph-based approach to cell image analysis. We define graph transition energy to quantify morphological differences between image sets. A spectral graph theoretic regularization is applied to transform the feature space based on training examples of extremely different images to calibrate the quantification. Calibration is essential for a practical quantification method because we need to measure the confidence of the quantification. We applied our method to quantify the degree of partial fragmentation of mitochondria in collections of fluorescent cell images. We show that with transformation, the quantification can be more accurate and sensitive than that without transformation. We also show that our method outperforms competing methods, including neighbourhood component analysis and the multi-variate drug profiling method by Loo et al. We illustrate its utility with a study of Annonaceous acetogenins, a family of compounds with drug potential. Our result reveals that squamocin induces more fragmented mitochondria than muricin A. Availability: Mitochondrial cell images, their corresponding feature sets (SSLF and WSLF) and the source code of our proposed method are available at http://aiia.iis.sinica.edu.tw/. Contact: chunnan@iis.sinica.edu.tw Supplementary information: Supplementary data are available at Bioinformatics online. PMID:20529919

  3. Toward real-time regional earthquake simulation II: Real-time Online earthquake Simulation (ROS) of Taiwan earthquakes

    NASA Astrophysics Data System (ADS)

    Lee, Shiann-Jong; Liu, Qinya; Tromp, Jeroen; Komatitsch, Dimitri; Liang, Wen-Tzong; Huang, Bor-Shouh

    2014-06-01

    We developed a Real-time Online earthquake Simulation system (ROS) to simulate regional earthquakes in Taiwan. The ROS uses a centroid moment tensor solution of seismic events from a Real-time Moment Tensor monitoring system (RMT), which provides all the point source parameters including the event origin time, hypocentral location, moment magnitude and focal mechanism within 2 min after the occurrence of an earthquake. Then, all of the source parameters are automatically forwarded to the ROS to perform an earthquake simulation, which is based on a spectral-element method (SEM). A new island-wide, high resolution SEM mesh model is developed for the whole Taiwan in this study. We have improved SEM mesh quality by introducing a thin high-resolution mesh layer near the surface to accommodate steep and rapidly varying topography. The mesh for the shallow sedimentary basin is adjusted to reflect its complex geometry and sharp lateral velocity contrasts. The grid resolution at the surface is about 545 m, which is sufficient to resolve topography and tomography data for simulations accurate up to 1.0 Hz. The ROS is also an infrastructural service, making online earthquake simulation feasible. Users can conduct their own earthquake simulation by providing a set of source parameters through the ROS webpage. For visualization, a ShakeMovie and ShakeMap are produced during the simulation. The time needed for one event is roughly 3 min for a 70 s ground motion simulation. The ROS is operated online at the Institute of Earth Sciences, Academia Sinica (http://ros.earth.sinica.edu.tw/). Our long-term goal for the ROS system is to contribute to public earth science outreach and to realize seismic ground motion prediction in real-time.

  4. Toward real-time regional earthquake simulation of Taiwan earthquakes

    NASA Astrophysics Data System (ADS)

    Lee, S.; Liu, Q.; Tromp, J.; Komatitsch, D.; Liang, W.; Huang, B.

    2013-12-01

    We developed a Real-time Online earthquake Simulation system (ROS) to simulate regional earthquakes in Taiwan. The ROS uses a centroid moment tensor solution of seismic events from a Real-time Moment Tensor monitoring system (RMT), which provides all the point source parameters including the event origin time, hypocentral location, moment magnitude and focal mechanism within 2 minutes after the occurrence of an earthquake. Then, all of the source parameters are automatically forwarded to the ROS to perform an earthquake simulation, which is based on a spectral-element method (SEM). We have improved SEM mesh quality by introducing a thin high-resolution mesh layer near the surface to accommodate steep and rapidly varying topography. The mesh for the shallow sedimentary basin is adjusted to reflect its complex geometry and sharp lateral velocity contrasts. The grid resolution at the surface is about 545 m, which is sufficient to resolve topography and tomography data for simulations accurate up to 1.0 Hz. The ROS is also an infrastructural service, making online earthquake simulation feasible. Users can conduct their own earthquake simulation by providing a set of source parameters through the ROS webpage. For visualization, a ShakeMovie and ShakeMap are produced during the simulation. The time needed for one event is roughly 3 minutes for a 70 sec ground motion simulation. The ROS is operated online at the Institute of Earth Sciences, Academia Sinica (http://ros.earth.sinica.edu.tw/). Our long-term goal for the ROS system is to contribute to public earth science outreach and to realize seismic ground motion prediction in real-time.

  5. The Crystallography of Quasicrystals

    NASA Astrophysics Data System (ADS)

    Rabson, David Alan

    A century ago, E. S. Fedorov, A. Schonflies, and W. Barlow, working independently, classified the 230 distinct symmetry groups of objects repeated periodically in three-dimensional space. The 230 space groups determine the symmetries of macroscopic properties and provide crystallographers with their most important tool in deducing structure; as such, they find use in biology, organic chemistry, and virology as well as in physics, geology, and materials science. With the discovery in 1984 of quasicrystals, well-ordered but aperiodic metallic alloys with crystallographically forbidden rotational symmetries, the need arose to develop a space-group theory for these new materials. Based on the work by Rokhsar, Wright, and Mermin^1 in two dimensions, Rabson, Mermin, Rokhsar, and Wright have classified all quasicrystal and crystal three -dimensional axial space groups.^2 Our classification, proceeding in reciprocal space, is elementary, does not rely on projecting higher-dimensional crystallographic space groups, and is valid for arbitrary rotational symmetry. As an additional illustration of quasicrystallographic space groups, I derive and demonstrate algorithms that produce two-dimensional tilings of rhombi with each of the possible plane-group symmetries.^3 While the analogous task for crystallographic plane groups is trivial, the lack of translational symmetry in a quasicrystal tiling makes these constructions interesting. Since the symmetry of a quasicrystal appears more naturally in reciprocal than in direct space, it is not surprising that some of the resulting tilings seem intricate, although in fact their symmetries are quite simple. ftn^1 Acta Cryst. A44, 197-211 (1988). ^2 "The Space Groups of Axial Crystals and Quasicrystals," preprint. ^3See also Rabson, Ho, and Mermin, Acta Cryst. A44, 678 (1988) and Acta Cryst. A45, 538 (1989).

  6. Physicochemical aspects of reaction of ozone with galactolipid and galactolipid-tocopherol layers.

    PubMed

    Rudolphi-Skórska, Elżbieta; Filek, Maria; Zembala, Maria

    2014-07-01

    The impact of reaction of galactolipids with ozone on the physicochemical properties of their monolayers was examined. In Megli and Russo (Biochim Biophys Acta, 1778:143-152, 2008), Cwiklik and Jungwirth (Chem Phys Lett, 486:99-103, 2010), Jurkiewicz et al. (Biochim Biophys Acta, 1818:2388-2402, 2012), Khabiri et al. (Chem Phys Lett, 519:93-99, 2012), and Conte et al. (Biochim Biophys Acta, 1828:510-517, 2013), the properties of layers formed from model mixtures composed of chosen lipids and selected oxidation products were studied, whereas in this work, question was raised as to how the oxidation reactions taking place in situ affect the physical properties of the galactolipid layers. So, set experiment should take into account the effect of all reaction products. The mechanical characteristics of monolayers of monogalactosyldiacyl-glycerol (MGDG) and digalactosyldiacylglycerol (DGDG) were determined by Langmuir trough technique, and the electrical properties of liposomes formed from these lipids by measuring their electrophoretic mobility. Considerable loss of galactolipid molecules forming monolayers was found at ozone concentrations (in aqueous medium) higher than 0.1 ppm with a stronger effect measured for MGDG. That goes along with the greater amounts of MDA found in the extracts of oxidized MGDG films compared with DGDG. Based on this, it was concluded that an additional galactose group present in DGDG molecules acts protectively under oxidative conditions. The surface tension of the solutions (of small volume) contacting the oxidized galactolipids films was significantly reduced, indicating the presence of soluble in polar media, surface active reaction products. The presence of α-tocopherol in mixtures with tested galactolipids at a molar ratio of lipid to tocopherol equal to 1.7:1 caused some inhibition of lipid oxidation, reducing the decrease of amount of lipid particles forming the monolayer. Here, also protective effect of α-tocopherol was greater

  7. Ruminant rhombencephalitis-associated Listeria monocytogenes alleles linked to a multilocus variable-number tandem-repeat analysis complex.

    PubMed

    Balandyté, Lina; Brodard, Isabelle; Frey, Joachim; Oevermann, Anna; Abril, Carlos

    2011-12-01

    Listeria monocytogenes is among the most important food-borne pathogens and is well adapted to persist in the environment. To gain insight into the genetic relatedness and potential virulence of L. monocytogenes strains causing central nervous system (CNS) infections, we used multilocus variable-number tandem-repeat analysis (MLVA) to subtype 183 L. monocytogenes isolates, most from ruminant rhombencephalitis and some from human patients, food, and the environment. Allelic-profile-based comparisons grouped L. monocytogenes strains mainly into three clonal complexes and linked single-locus variants (SLVs). Clonal complex A essentially consisted of isolates from human and ruminant brain samples. All but one rhombencephalitis isolate from cattle were located in clonal complex A. In contrast, food and environmental isolates mainly clustered into clonal complex C, and none was classified as clonal complex A. Isolates of the two main clonal complexes (A and C) obtained by MLVA were analyzed by PCR for the presence of 11 virulence-associated genes (prfA, actA, inlA, inlB, inlC, inlD, inlE, inlF, inlG, inlJ, and inlC2H). Virulence gene analysis revealed significant differences in the actA, inlF, inlG, and inlJ allelic profiles between clinical isolates (complex A) and nonclinical isolates (complex C). The association of particular alleles of actA, inlF, and newly described alleles of inlJ with isolates from CNS infections (particularly rhombencephalitis) suggests that these virulence genes participate in neurovirulence of L. monocytogenes. The overall absence of inlG in clinical complex A and its presence in complex C isolates suggests that the InlG protein is more relevant for the survival of L. monocytogenes in the environment.

  8. An examination of the regulatory mechanism of Pxdn mutation-induced eye disorders using microarray analysis

    PubMed Central

    YANG, YANG; XING, YIQIAO; LIANG, CHAOQUN; HU, LIYA; XU, FEI; MEI, QI

    2016-01-01

    The present study aimed to identify biomarkers for peroxidasin (Pxdn) mutation-induced eye disorders and study the underlying mechanisms involved in this process. The microarray dataset GSE49704 was used, which encompasses 4 mouse samples from embryos with Pxdn mutation and 4 samples from normal tissues. After data preprocessing, the differentially expressed genes (DEGs) between Pxdn mutation and normal tissues were identified using the t-test in the limma package, followed by functional enrichment analysis. The protein-protein interaction (PPI) network was constructed based on the STRING database, and the transcriptional regulatory (TR) network was established using the GeneCodis database. Subsequently, the overlapping DEGs with high degrees in two networks were identified, as well as the sub-network extracted from the TR network. In total, 121 (75 upregulated and 46 downregulated) DEGs were identified, and these DEGs play important roles in biological processes (BPs), including neuron development and differentiation. A PPI network containing 25 nodes such as actin, alpha 1, skeletal muscle (Acta1) and troponin C type 2 (fast) (Tnnc2), and a TR network including 120 nodes were built. By comparing the two networks, seven crucial genes which overlapped were identified, including cyclin-dependent kinase inhibitor 1B (Cdkn1b), Acta1 and troponin T type 3 (Tnnt3). In the sub-network, Cdkn1b was predicted as the target of miRNAs such as mmu-miR-24 and transcription factors (TFs) including forkhead box O4 (FOXO4) and activating enhancer binding protein 4 (AP4). Thus, we suggest that seven crucial genes, including Cdkn1b, Acta1 and Tnnt3, play important roles in the progression of eye disorders such as glaucoma. We suggest that Cdkn1b exert its effects via the inhibition of proliferation and is mediated by mmu-miR-24 and targeted by the TFs FOXO4 and AP4. PMID:27121343

  9. MicroRNA-495 Inhibits Gastric Cancer Cell Migration and Invasion Possibly via Targeting High Mobility Group AT-Hook 2 (HMGA2)

    PubMed Central

    Wang, Huashe; Jiang, Zhipeng; Chen, Honglei; Wu, Xiaobin; Xiang, Jun; Peng, Junsheng

    2017-01-01

    Background Gastric cancer is one of the most common malignancies, and has a high mortality rate. miR-495 acts as a suppressor in some cancers and HMGA2 (high mobility group AT-hook 2) is a facilitator for cell growth and epithelial-mesenchymal transition (EMT), but little is known about their effect in gastric cancer. This study aimed to investigate the role and mechanism of miR-495 in gastric cancer. Material/Methods miR-495 levels were quantitatively analyzed in gastric cancer tissue and GES-1, SGC-7901, BGC-823, and HGC-27 cell lines by qRT-PCR. Levels of miR-495 and HMGA2 were altered by cell transfection, after which cell migration and invasion were examined by Transwell and E-cadherin (CDH1); vimentin (VIM), and alpha smooth muscle actin (ACTA2) were detected by qRT-PCR and Western blotting. The interaction between miR-495 and HMGA2 was verified by dual-luciferase reporter assay. Results miR-495 was significantly downregulated in cancer tissue and cell lines (p<0.05). Its overexpression inhibited cell migration and invasion, elevated CDH1, and inhibited VIM and ACTA2 levels in BGC-823 and HGC-27 cells. miR-495 directly inhibited HMGA2, which was upregulated in gastric cancer tissue, and promoted cell migration and invasion, inhibited CDH1, and elevated VIM and ACTA2. Conclusions miR-495 acts as a tumor suppressor in gastric cancer by inhibiting cell migration and invasion, which may be associated with its direct inhibition on HMGA2. These results suggest a promising therapeutic strategy for gastric cancer treatment. PMID:28159956

  10. A new calibration curve for carbonate clumped isotope thermometer of land snail shells (aragonite)

    NASA Astrophysics Data System (ADS)

    Zhang, N.; Yamada, K.; Yoshida, N.

    2013-12-01

    Clumped isotope data (Δ47) of carbonate is considered as a useful tool to reflect both the temperature and oxygen isotopic composition of water where the carbonate grew [1]. Zarrur et al. reported the relationship between snail shell calcification temperatures and the mean annual/ activity season ambient temperatures based on a calibration curve established by Ghosh et al. [2]. However, the clumped isotope temperature is always higher than the environment temperature. For better understanding this phenomenon, we present a new empirical calibration curve based on land snail shells (aragonite) cultured in the controlled temperature environment. In 2012, we cultured the land snails ';Euhadra' which were collected from Yokohama, Japan. They were cultured from eggs to adults around 6-8 months under the temperature of 20°, 25° and 30°, respectively. Each temperature group contains 15-20 snails. All of them were fed by cabbages during their life span. To study the effect of ingested carbonate, some of them were fed by Ca3(PO4)2 powder while others were fed by CaCO3 powder. Clumped isotope data for all samples were analyzed by a Thermo Finnigan MAT 253 Mass Spectrometer and calibrated by an ';absolute reference frame' [3]. We found an empirical linear relationship between Δ47 and controlled ambient temperature, which is slightly deviated from the published theoretical and experimental calibration curves based on both inorganic and biogenic materials. We will discuss the potential controlling factors caused this kind of deviation combine with the land snail growth environment. [1] Ghosh et al., 2006, Geochimica et Cosmochimica Acta. 70, 1439-1456 [2] Zaarur et al. 2011. Geochimica et Cosmochimica Acta, 75, 6859-6869 [3] Dennis et al., 2011. Geochimica et Cosmochimica Acta 75, 7117-7131

  11. Meta-analysis as Statistical and Analytical Method of Journal’s Content Scientific Evaluation

    PubMed Central

    Masic, Izet; Begic, Edin

    2015-01-01

    Introduction: A meta-analysis is a statistical and analytical method which combines and synthesizes different independent studies and integrates their results into one common result. Goal: Analysis of the journals “Medical Archives”, “Materia Socio Medica” and “Acta Informatica Medica”, which are located in the most eminent indexed databases of the biomedical milieu. Material and methods: The study has retrospective and descriptive character, and included the period of the calendar year 2014. Study included six editions of all three journals (total of 18 journals). Results: In this period was published a total of 291 articles (in the “Medical Archives” 110, “Materia Socio Medica” 97, and in “Acta Informatica Medica” 84). The largest number of articles was original articles. Small numbers have been published as professional, review articles and case reports. Clinical events were most common in the first two journals, while in the journal “Acta Informatica Medica” belonged to the field of medical informatics, as part of pre-clinical medical disciplines. Articles are usually required period of fifty to fifty nine days for review. Articles were received from four continents, mostly from Europe. The authors are most often from the territory of Bosnia and Herzegovina, then Iran, Kosovo and Macedonia. Conclusion: The number of articles published each year is increasing, with greater participation of authors from different continents and abroad. Clinical medical disciplines are the most common, with the broader spectrum of topics and with a growing number of original articles. Greater support of the wider scientific community is needed for further development of all three of the aforementioned journals. PMID:25870484

  12. Involvement of cytoskeletal proteins in the barrier function of the human erythrocyte membrane. III. Permeability of spectrin-depleted inside-out membrane vesicles to hydrophilic nonelectrolytes. Formation of leaks by chemical or enzymatic modification of membrane proteins.

    PubMed

    Klonk, S; Deuticke, B

    1992-04-29

    Spectrin-depleted inside-out vesicles (IOV's) prepared from human erythrocyte membranes were characterized in terms of size, ground permeability to hydrophilic nonelectrolytes and their sensitivity to modification by SH reagents, DIDS and trypsin. IOV's proved to have the same permeability of their lipid domain to erythritol as native erythrocytes, in contrast to resealed ghosts (Klonk, S. and Deuticke, B. (1992) Biochim. Biophys. Acta 1106, 126-136 (Part I in this series)), which have a residual leak. On the other hand, IOV's have a slightly elevated permeability for mannitol and sucrose, nonelectrolytes which are almost (mannitol) or fully (sucrose) impermeant in the native membrane. These increased fluxes, which have a high activation energy and can be stimulated by phloretin, are, however, also much smaller than the corresponding leak fluxes observed in resealed ghosts. In view of these differences, formation of IOV's can be concluded to go along with partial annealing of barrier defects persisting in the erythrocyte membrane after preparation of resealed ghosts. Oxidation of SH groups of the IOV membrane by diamide produces an enhancement of permeability for hydrophilic nonelectrolytes which is much less pronounced than that induced by a similar treatment of erythrocytes or ghosts (Klonk, S. and Deuticke, B. (1992) Biochim. Biophys. Acta 1106, 126-136 (Part I in this series)). Moreover, proteolytic treatment of the vesicle membrane, although leading to a marked digestion of integral membrane proteins, only induces a minor, saturating increase of permeability, much lower than that in trypsinized resealed ghosts (Klonk, S. and Deuticke, B. (1992) Biochim. Biophys. Acta 1106, 137-142 (Part II of this series)). Since absence of the cytoskeletal proteins, spectrin and actin, is the major difference between IOV's and resealed ghosts, these results may be taken as further evidence for a dependence of the barrier properties of the erythrocyte membrane bilayer domain

  13. The Integration of Nanoscale Techniques for an Improved Battery Technology

    DTIC Science & Technology

    2012-06-08

    Journal of Polymer Science, Part B: Polymer Physics 31 (1993) (13) 1941. [110]. Y. Zheng, F. Chia, G. Ungar , P.V. Wright, Chemical Communications...2000) (16) 1459. 42 [111]. Y. Zheng, F. Chia, G. Ungar , T.H. Richardson, P.V. Wright, Electrochimica Acta 46 (2001) (10-11) 1397. [112]. Y...Zheng, F. Chia, G. Ungar , P.V. Wright, Journal of Power Sources 97-98 (2001) 641. [113]. V. Percec, G. Johansson, J. Heck, G. Ungar , S.V. Batty

  14. A triclinic polymorph of catena-poly[[bis-(N,N-dimethyl-formamide-κO)cobalt(II)]-di-μ-1,5-dicyanamido-κ(4)N(1):N(5)].

    PubMed

    Meng, S C

    2012-11-01

    The title compound, [Co(C(2)N(3))(2)(C(3)H(7)NO)(2)](n), is a triclinic polymorph of the previously reported monoclinic structure [Tong et al. (2003 ▶). Acta Cryst. E59, m405-m407]. The Co(II) ion lies on an inversion centre and adopts an almost regular octa-hedral N(4)O(2) coordination geometry. Adjacent Co(II) atoms are connected by two bridging dicyanamide ligands, resulting in the formation of neutral chains parallel to the b axis. The title complex is isotypic with the Mn(II) analogue but not with the Ni(II) analogue.

  15. 4,4'-Dimethoxy-benzophenone: a triclinic polymorph.

    PubMed

    Fun, Hoong-Kun; Franklin, S; Jebas, Samuel Robinson; Balasubramanian, T

    2008-06-13

    The title compound, C(15)H(14)O(3), has been found to crystallize as a new triclinic polymorph. The asymmetric unit of the present structure, as in the previously reported monoclinic structure [Norment & Karle (1962 ▶). Acta Cryst. 15, 873-878], contains two independent mol-ecules, which differ slightly in the orientations of the two benzene rings. The crystal packing of the triclinic polymorph is stabilized by inter-molecular C-H⋯O hydrogen bonds and C-H⋯π inter-actions.

  16. Triclinic Polymorph of Bis(triphenylsilyl) Oxide Toluene Disolvate

    DTIC Science & Technology

    2012-01-01

    Triclinic polymorph of bis(triphenylsilyl) oxide toluene disolvate Andrew P. Purdy,a* Emily Smoot,a‡ Ray J. Butcherb and Andrew Kerrc aNaval Research... triclinic (P1) instead of possessing the previously reported rhombohedral symmetry [Hönle et al. (1990). Acta Cryst. C46, 1982–1984]. Each of the –SiPh3... structures of related compounds, see: Glidewell & Liles (1978); Morosin & Harrah (1981); Suwińska et al. (1986). For the determination by IR

  17. Laser Hazards Bibliography, January 1991

    DTIC Science & Technology

    1991-01-31

    immunologic effect, Z Exp Chir, 10(5): 301-306 (1977) (English abstract, German). 137. Mester, E., Korenyi-Both, T., Spizy, T., Scher, A., and Varga , L...photocoagulation, Acta Soc Ophth Jpn, 78(12): 1442-1448 (10 December 1974) (English abstract). 507. Sanchez del Campo , F., Puchades Orts, A., Panchon Ruiz, A...Ophthalmol, 44(1): 113-120 (1977). 212. Henry , M. M., Henry , L. M., and Henry , L. M., A possible cause of chronic cystic maculopathy, Ann Ophthalmol

  18. Investigation of Material Problems for High Temperature, High Power Space Energy-Conversion Systems

    DTIC Science & Technology

    1985-01-01

    Nasser, North Holland Publishing, Amsterdam). 2.117 I-W. Chen and A. Argon: Creep Cavitation in 304 Stainless Steel , Acta Metallurgica 29, 1321, 1981...eyepieces). Picture size a 24 x 36mm. * Macrohardness : Rockwell type macromet hardness tester. Loads: 60, 100, 150 Kgs. Scales: a) B Scale, 1/16" Steel ...1700 cals/mole for Mo and 200 cals/mole for steel . Fig. 4.36 shows the effect of powder purity on ductile-brittle transition temperature of tungsten and

  19. Comparison of beetroot extracts originating from several sites using time-resolved laser-induced fluorescence spectroscopy

    NASA Astrophysics Data System (ADS)

    Rabasović, M. S.; Šević, D.; Terzić, M.; Marinković, B. P.

    2012-05-01

    Beetroot (Beta vulgaris) juice contains a large number of fluorophores which can fluoresce. There is a growing interest in beetroot extracts analysis. In contrast, there is only limited information about beetroot obtained without sample preparation and/or extraction of components from the sample. In this work, we continue our previous study (Rabasović et al 2009 Acta Phys. Pol. A 116 570-2), analyzing and comparing beetroot extracts from several sites, using the time-resolved laser-induced fluorescence technique to measure the fluorescence of samples at different excitation wavelengths (340-470 nm) and for different sample dilutions.

  20. Multiscale Modeling and Process Optimization for Engineered Microstructural Complexity

    DTIC Science & Technology

    2007-10-26

    in hydrogen-implanted single-crystal BaTiO3 Journal of Applied Physics 97: Art. No. 074311, 2005. 25. R. T. Brewer , D. A. Boyd, M. Y. El-Naggar...ferroelectric domains. Part II: Grain boundaries and defect pinning. Acta Materialia 53: 199-209, 2005. 28. M.Y. El-Naggar, D.A. Boyd, and D.G...2003. 37. R.T. Brewer , H.A. Atwater, J.R. Groves and P.N. Arendt Reflection high-energy electron diffraction analysis of polycrystalline MgO films