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Sample records for action direct sale

  1. 78 FR 39767 - Notice of Realty Action: Direct Sale of Public Land in Blaine County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ... sale. The BLM has completed a mineral potential report which concluded there ] are no known mineral values in the lands proposed for sale. The BLM proposes that conveyance of the Federal mineral interests... Bureau of Land Management Notice of Realty Action: Direct Sale of Public Land in Blaine County, ID...

  2. 77 FR 13145 - Notice of Realty Action: Direct Sale of Public Land in Esmeralda County, Nevada

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-05

    ... Federal Land Policy and Management Act of 1976 (FLPMA), as amended, and BLM sales and mineral conveyance... Federal mineral interests occur simultaneously with the sale of the land. In addition to the appraised... 4500022284; TAS: 14X1109] Notice of Realty Action: Direct Sale of Public Land in Esmeralda County,...

  3. 76 FR 62831 - Notice of Realty Action: Direct Sale of Public Land in Shasta County, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-11

    ... Bureau of Land Management Notice of Realty Action: Direct Sale of Public Land in Shasta County, CA AGENCY..., more or less, in Shasta County, California. The public land would be sold to the County of Shasta for... INFORMATION: The following parcel of public land is being proposed for direct sale to the County of Shasta...

  4. 75 FR 35083 - Notice of Realty Action; Direct Sale of Public Lands in Lincoln County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR Bureau of Land Management Notice of Realty Action; Direct Sale of Public Lands in Lincoln County, ID AGENCY: Bureau of Land Management, Interior. ACTION: Notice of realty action. SUMMARY: The Bureau of...

  5. 75 FR 444 - Notice of Realty Action: Direct Sale of Public Lands in Tehama County, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-05

    ... Bureau of Land Management Notice of Realty Action: Direct Sale of Public Lands in Tehama County, CA AGENCY: Bureau of Land Management, Interior. ACTION: Notice of realty action. SUMMARY: The Bureau of Land Management (BLM) proposes to sell a 70.72- acre parcel of public land in Tehama County, California, to...

  6. 75 FR 13303 - Notice of Realty Action: Direct Sale of Public Lands in Riverside County, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-19

    ... public lands in the N lying south of the Chino Wash Flood Control Levee. The area described contains... Bureau of Land Management Notice of Realty Action: Direct Sale of Public Lands in Riverside County, CA AGENCY: Bureau of Land Management, Interior. ACTION: Notice of Realty Action. SUMMARY: The Bureau of...

  7. 75 FR 60478 - Notice of Realty Action: Direct Sale of Public Lands in Santa Fe County, NM

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-30

    ... Bureau of Land Management Notice of Realty Action: Direct Sale of Public Lands in Santa Fe County, NM... direct sale to Edward Black pursuant to the Act of December 22, 1928, as amended, and an Interior Board of Land Appeals Settlement Agreement for the amount of $10,000. The sale is to resolve a class...

  8. 78 FR 71641 - Notice of Realty Action: Direct Sale of Public Land in Graham County, AZ

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-29

    ... Bureau of Land Management Notice of Realty Action: Direct Sale of Public Land in Graham County, AZ AGENCY... acres of public land in Graham County, Arizona, to Gilligan and Blanca Bowman (proponents) for not less... business hours. SUPPLEMENTARY INFORMATION: The following described parcel of public land in Graham...

  9. 77 FR 61023 - Notice of Realty Action: Direct Sale of Public Land in Shasta County, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-05

    ... Bureau of Land Management Notice of Realty Action: Direct Sale of Public Land in Shasta County, CA AGENCY...), Redding Field Office, proposes to sell a parcel of public land totaling approximately 40 acres in Shasta... Act of 1976 (FLPMA), as amended (43 U.S.C. 1713 and 1719). Mount Diablo Meridian T. 34 N., R. 1...

  10. 78 FR 53780 - Notice of Realty Action: Direct Sale of Public Land in Doña Ana County, NM

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-30

    ... were no known mineral values on the land proposed for sale. The BLM proposes the conveyance of the Federal mineral interests would occur simultaneously with the sale of the land. In addition to this Notice... Bureau of Land Management Notice of Realty Action: Direct Sale of Public Land in Do a Ana County,...

  11. 76 FR 68784 - Notice of Realty Action: Direct Sale of Public Land in Santa Clara County, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ... for sale. The BLM proposes that conveyance of the Federal mineral interests would occur simultaneously... Bureau of Land Management Notice of Realty Action: Direct Sale of Public Land in Santa Clara County, CA.... DATES: Written comments regarding the proposed sale must be received by the BLM on or before December...

  12. 76 FR 68783 - Notice of Realty Action: Direct (Non-Competitive) Sale of Reversionary Interest in Benton County, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ... Bureau of Land Management Notice of Realty Action: Direct (Non-Competitive) Sale of Reversionary Interest... INFORMATION below has been determined suitable for direct sale and release to the City of West Richland... parcel can be used is restricted by the reversionary clause. DATES: Comments regarding the proposed...

  13. 78 FR 15044 - Notice of Realty Action: Direct Sale of Public Land in Pinal County, AZ

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-08

    ... of 1976, as amended (FLPMA) and sales and mineral conveyance regulations. DATES: Comments regarding... concluded the public interest would be best served by a direct sale. The BLM has prepared a mineral... proposed for direct sale. Therefore, the BLM proposes that the conveyance of the Federal mineral...

  14. 78 FR 8188 - Notice of Realty Action: Proposed (Non-Competitive) Direct Sale of Public Land in Carbon County, UT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-05

    ... in Carbon County, UT AGENCY: Bureau of Land Management, Interior. ACTION: Notice of realty action... acres of public land in Carbon County, Utah, at not less than the appraised fair market value to Hunt... Carbon County, Utah, are proposed for direct sale, subject to the applicable provisions of Sections...

  15. 76 FR 16810 - Notice of Realty Action: Non-Competitive (Direct) Sale of Public Land in Hot Springs County, WY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-25

    ... Bureau of Land Management Notice of Realty Action: Non-Competitive (Direct) Sale of Public Land in Hot...: A 10-acre parcel of public land in Hot Springs County, Wyoming is being considered for non... following described public land in Hot Springs County, Wyoming has been examined and found suitable for...

  16. 76 FR 50492 - Notice of Realty Action: Direct Sale of Public Land in San Benito County, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-15

    ... Bureau of Land Management Notice of Realty Action: Direct Sale of Public Land in San Benito County, CA... approximately 15.61 acres in San Benito County, California. The public land would be sold to Windfield Ranch... contains approximately 15.61 acres, more or less, in San Benito County. The public land was...

  17. 75 FR 39273 - Notice of Realty Action: Proposed Direct Sale of Public Land, Chaves County, NM

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-08

    ... parcels are being proposed for direct sale to the Roswell Gun Club at no less than the appraised fair... property is currently owned by the New Mexico Military Institute and the Roswell Gun Club. The unauthorized... Roswell Gun Club, firing ranges, sightings-in range, small arms firing range, and various earthen...

  18. 78 FR 40503 - Notice of Realty Action: Direct Sale of Public Lands in Pima County, AZ

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-05

    ... 1976, as amended (FLPMA), and the BLM sales and mineral conveyance regulations for the appraised fair... that the lands identified for sale have no known mineral value. The BLM proposes that conveyance of the Federal mineral interests would occur simultaneously with the sale of the land. The project is...

  19. 77 FR 24978 - Notice of Realty Action: Non-Competitive (Direct) Sale of Public Land in Washakie County, Wyoming

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-26

    ..., Wyoming, by non- competitive (direct) sale to the town of Ten Sleep under the provisions of the Federal... United States. 3. A reservation of a right-of-way for a Federal-aid Highway (Ten Sleep-Big Trails Road.... This land is being offered by direct sale to the Town of Ten Sleep pursuant to 43 CFR 2711.3-3....

  20. 75 FR 6701 - Notice of Realty Action: Proposed Direct Sale of Public Land, Utah

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-10

    ... land will be segregated from all forms of appropriation under the public land laws, including location and entry under the United States mining laws, except the sale provisions of the Federal Land Policy... affecting the identified public land. The effect of segregation will terminate upon: (1) Issuance of...

  1. 76 FR 47237 - Notice of Realty Action: Direct Sale of Public Land in Monterey County, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-04

    ... appraised fair market value of $25,000. DATES: Written comments regarding the proposed sale must be received... including your address, phone number, e-mail address, or other personal identifying information in your comment, be advised that your entire comment--including your personal identifying information-- may...

  2. 78 FR 76855 - Notice of Realty Action: Non-Competitive (Direct) Sale of Public Land in Campbell County, WY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ... totaling 4.15 acres in Campbell County, Wyoming, to the Craig G. and Peggy S. Means Revocable Trust under... Campbell County, WY AGENCY: Bureau of Land Management, Interior. ACTION: Notice of realty action. SUMMARY... sale of the lands until February 3, 2014. ADDRESSES: Send written comments concerning this notice...

  3. 78 FR 76854 - Notice of Realty Action: Non-Competitive (Direct) Sale of Public Land in Sheridan County, WY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ...The Bureau of Land Management proposes to sell eight parcels of public land totaling 208.12 acres in Sheridan County, Wyoming, to Farmland Reserve, Inc. (FRI) under the direct sale provisions of the Federal Land Policy and Management Act of 1976 (FLPMA), for not less than the appraised fair market value of...

  4. 40 CFR 73.72 - Direct sales.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 17 2013-07-01 2013-07-01 false Direct sales. 73.72 Section 73.72... ALLOWANCE SYSTEM Auctions, Direct Sales, and Independent Power Producers Written Guarantee § 73.72 Direct sales. Allowances that were formerly part of the direct sale program, which has been terminated...

  5. 40 CFR 73.72 - Direct sales.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 17 2012-07-01 2012-07-01 false Direct sales. 73.72 Section 73.72... ALLOWANCE SYSTEM Auctions, Direct Sales, and Independent Power Producers Written Guarantee § 73.72 Direct sales. Allowances that were formerly part of the direct sale program, which has been terminated...

  6. 40 CFR 73.72 - Direct sales.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 17 2014-07-01 2014-07-01 false Direct sales. 73.72 Section 73.72... ALLOWANCE SYSTEM Auctions, Direct Sales, and Independent Power Producers Written Guarantee § 73.72 Direct sales. Allowances that were formerly part of the direct sale program, which has been terminated...

  7. 40 CFR 73.72 - Direct sales.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Direct sales. 73.72 Section 73.72... ALLOWANCE SYSTEM Auctions, Direct Sales, and Independent Power Producers Written Guarantee § 73.72 Direct sales. Allowances that were formerly part of the direct sale program, which has been terminated...

  8. 40 CFR 73.72 - Direct sales.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 16 2011-07-01 2011-07-01 false Direct sales. 73.72 Section 73.72... ALLOWANCE SYSTEM Auctions, Direct Sales, and Independent Power Producers Written Guarantee § 73.72 Direct sales. Allowances that were formerly part of the direct sale program, which has been terminated...

  9. 75 FR 67393 - Notice of Realty Action: Direct Sale of Public Lands in Santa Barbara County, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    ... land sale and mineral conveyance regulations at 43 CFR 2710 and 2720. DATES: Comments regarding the... exception of oil and gas, the lands identified for sale are considered to have no known mineral value and the proposed sale would include the conveyance of both the surface interests and remaining...

  10. 14 CFR 212.7 - Direct sales.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Direct sales. 212.7 Section 212.7... REGULATIONS CHARTER RULES FOR U.S. AND FOREIGN DIRECT AIR CARRIERS § 212.7 Direct sales. (a) Certificated and foreign air carriers may sell or offer for sale, and operate, as principal, Public Charter flights...

  11. 14 CFR 212.7 - Direct sales.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Direct sales. 212.7 Section 212.7... REGULATIONS CHARTER RULES FOR U.S. AND FOREIGN DIRECT AIR CARRIERS § 212.7 Direct sales. (a) Certificated and foreign air carriers may sell or offer for sale, and operate, as principal, Public Charter flights...

  12. 14 CFR 212.7 - Direct sales.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Direct sales. 212.7 Section 212.7... REGULATIONS CHARTER RULES FOR U.S. AND FOREIGN DIRECT AIR CARRIERS § 212.7 Direct sales. (a) Certificated and foreign air carriers may sell or offer for sale, and operate, as principal, Public Charter flights...

  13. 14 CFR 212.7 - Direct sales.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Direct sales. 212.7 Section 212.7... REGULATIONS CHARTER RULES FOR U.S. AND FOREIGN DIRECT AIR CARRIERS § 212.7 Direct sales. (a) Certificated and foreign air carriers may sell or offer for sale, and operate, as principal, Public Charter flights...

  14. 14 CFR 212.7 - Direct sales.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Direct sales. 212.7 Section 212.7... REGULATIONS CHARTER RULES FOR U.S. AND FOREIGN DIRECT AIR CARRIERS § 212.7 Direct sales. (a) Certificated and foreign air carriers may sell or offer for sale, and operate, as principal, Public Charter flights...

  15. 77 FR 40897 - Notice of Realty Action: Proposed Direct Sale of Public Land in Harney County, OR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-11

    ... comments concerning this proposed sale may be submitted to Three Rivers Resource Area Field Manager, BLM... use a telecommunications device for the deaf (TDD) may call the Federal Information Relay Service... the BLM Three Rivers Resource Management Plan (RMP) for Land Tenure. The 1992 BLM Three Rivers RMP...

  16. 75 FR 28650 - Notice of Realty Action: Proposed Direct Sale of Public Lands in Riverside County, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-21

    ... market value of $77,000. DATES: Comments regarding the proposed sale must be received by the BLM on or... Management Act of 1976 (FLPMA), as amended (43 U.S.C. 1713), at not less than the appraised fair market value... acres in Riverside County. The appraised fair market value is $77,000. The public land is identified...

  17. 76 FR 11264 - Notice of Realty Action: Proposed Direct Sale of Public Land in Shoshone County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ...: Written comments concerning this proposed sale may be submitted to Field Manager, BLM Coeur d'Alene Field Office, 3815 Schreiber Way, Coeur d'Alene, Idaho 83815. FOR FURTHER INFORMATION CONTACT: Janna Paronto, Realty Specialist, at 3815 Schreiber Way, Coeur d'Alene, Idaho 83815 or phone (208)...

  18. 78 FR 46600 - Notice of Realty Action: Direct Sale of Public Land (N-91073) for Affordable Housing Purposes in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-01

    ... Las Vegas, Clark County, NV AGENCY: Bureau of Land Management, Interior. ACTION: Notice of Realty... in the southern portion of the Las Vegas Valley in Clark County, Nevada, under the authorities of... Valley in Clark County, Nevada, further described as: Mount Diablo Meridian T. 22 S., R. 61 E., Sec....

  19. 75 FR 51841 - Notice of Realty Action: Proposed sale of Public Lands, Churchill County, NV

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-23

    ... 4500012544; TAS: 14X5260] Notice of Realty Action: Proposed sale of Public Lands, Churchill County, NV AGENCY... of public lands in Churchill County, Nevada, through direct sale procedures under the provisions of...: The following described public lands in Churchill County, Nevada, proposed for sale are located...

  20. 43 CFR 2711.3-3 - Direct sales.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Direct sales. 2711.3-3 Section 2711.3-3..., DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) SALES: FEDERAL LAND POLICY AND MANAGEMENT ACT Sales: Procedures § 2711.3-3 Direct sales. (a) Direct sales (without competition) may be utilized,...

  1. 43 CFR 2711.3-3 - Direct sales.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Direct sales. 2711.3-3 Section 2711.3-3..., DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) SALES: FEDERAL LAND POLICY AND MANAGEMENT ACT Sales: Procedures § 2711.3-3 Direct sales. (a) Direct sales (without competition) may be utilized,...

  2. 43 CFR 2711.3-3 - Direct sales.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Direct sales. 2711.3-3 Section 2711.3-3..., DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) SALES: FEDERAL LAND POLICY AND MANAGEMENT ACT Sales: Procedures § 2711.3-3 Direct sales. (a) Direct sales (without competition) may be utilized,...

  3. 43 CFR 2711.3-3 - Direct sales.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Direct sales. 2711.3-3 Section 2711.3-3..., DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) SALES: FEDERAL LAND POLICY AND MANAGEMENT ACT Sales: Procedures § 2711.3-3 Direct sales. (a) Direct sales (without competition) may be utilized,...

  4. 75 FR 18881 - Notice of Realty Action: Proposed Sale of Public Land in Caribou Co., ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... for direct sale. Without the lands proposed for sale, mineral development under this specific... of this land through sale to the mineral lessee. The mineral lessee would suffer substantial economic... laws and mineral leasing laws, except the sale provisions of the FLPMA. Until completion of the sale...

  5. 7 CFR 927.122 - Consumer direct pear sales.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Consumer direct pear sales. 927.122 Section 927.122... AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE PEARS GROWN IN OREGON AND WASHINGTON Rules and Regulations Exemptions and Safeguards § 927.122 Consumer direct pear...

  6. 7 CFR 927.122 - Consumer direct pear sales.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Consumer direct pear sales. 927.122 Section 927.122... AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE PEARS GROWN IN OREGON AND WASHINGTON Rules and Regulations Exemptions and Safeguards § 927.122 Consumer direct pear...

  7. 7 CFR 927.122 - Consumer direct pear sales.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Consumer direct pear sales. 927.122 Section 927.122... Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE PEARS GROWN IN OREGON AND WASHINGTON Rules and Regulations Exemptions and Safeguards § 927.122 Consumer direct pear...

  8. 76 FR 31627 - Notice of Realty Action: Competitive Sale of Public Lands in Lake County, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-01

    ... Bureau of Land Management Notice of Realty Action: Competitive Sale of Public Lands in Lake County, CA..., California. The sale will be conducted as a competitive bid auction in which interested bidders must submit...: Comments regarding the proposed sale must be received by the BLM on or before July 11, 2011. Sealed...

  9. 76 FR 6155 - Notice of Realty Action: Competitive Sale of Public Lands in Sandoval County, NM

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... Bureau of Land Management Notice of Realty Action: Competitive Sale of Public Lands in Sandoval County... of Land Management (BLM) proposes to offer, by competitive sale, a parcel of Federally owned land near Golden, New Mexico, containing approximately 130.56 acres. The sale will be subject to...

  10. 76 FR 44355 - Notice of Realty Action: Competitive Sale of Public Land in Carson City, NV

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-25

    ...; TAS: 14X1109] Notice of Realty Action: Competitive Sale of Public Land in Carson City, NV AGENCY... BLM Carson City District in Carson City, Nevada. The sales will be conducted as a competitive bid... the proposed sales to the BLM on or before September 8, 2011. The deadline for submission of...

  11. 24 CFR 291.210 - Direct sales procedures.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Direct sales procedures. 291.210 Section 291.210 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF HUD-ACQUIRED SINGLE FAMILY PROPERTY...

  12. 24 CFR 291.210 - Direct sales procedures.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Direct sales procedures. 291.210 Section 291.210 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF HUD-ACQUIRED SINGLE FAMILY PROPERTY...

  13. 24 CFR 291.210 - Direct sales procedures.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Direct sales procedures. 291.210 Section 291.210 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF HUD-ACQUIRED SINGLE FAMILY PROPERTY...

  14. 24 CFR 291.210 - Direct sales procedures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Direct sales procedures. 291.210 Section 291.210 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF HUD-ACQUIRED SINGLE FAMILY PROPERTY...

  15. 24 CFR 291.210 - Direct sales procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Direct sales procedures. 291.210 Section 291.210 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF HUD-ACQUIRED SINGLE FAMILY PROPERTY...

  16. 75 FR 79018 - Notice of Realty Action: Proposed Sale of Public Lands in Bear Lake County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-17

    ... Bureau of Land Management Notice of Realty Action: Proposed Sale of Public Lands in Bear Lake County, ID... Management (BLM) proposes the sale of 26 parcels of public lands totaling 1,543.14 acres in Bear Lake County... Bear Lake County, Idaho, are proposed for sale under the authority of Sections 203 and 209 of FLPMA...

  17. 77 FR 20413 - Notice of Realty Action: Modified Competitive, Sealed-Bid Sale of Public Land in Clark County, NV

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-04

    ...: 14X5232] Notice of Realty Action: Modified Competitive, Sealed-Bid Sale of Public Land in Clark County, NV... Management (BLM) proposes to offer by modified competitive, sealed-bid sale, one parcel of public land... (FMV) of $10,560,000. The parcel will be offered in a sale pursuant to the Southern Nevada Public...

  18. 76 FR 37373 - Notice of Realty Action: Competitive Sale of Public Lands in Colusa, Glenn, and Lake Counties...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-27

    ... Bureau of Land Management Notice of Realty Action: Competitive Sale of Public Lands in Colusa, Glenn, and... land totaling 1,003.40 acres in Colusa, Glenn, and Lake Counties, California. The sale will be... sale must be received by the BLM on or before August 11, 2011. Sealed bids must be received no...

  19. 77 FR 67021 - Notice of Realty Action: Competitive Sealed-Bid Sale of Public Land in Clark County, NV

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-08

    ...: 14X5232] Notice of Realty Action: Competitive Sealed-Bid Sale of Public Land in Clark County, NV AGENCY...) proposes to offer by competitive sealed-bid sale, one parcel of public land totaling approximately 12.5...), Public Law 105-263, as amended. The sale will be subject to the applicable provisions of Section 203...

  20. 78 FR 59055 - Notice of Realty Action: Modified Competitive Sealed-Bid Sale of Public Land at Schoolhouse Butte...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-25

    ... land sale and mineral conveyance regulations. DATES: The BLM must receive written comments regarding... procedures and conditions, CERCLA, maps delineating the individual sale parcels, mineral potential report...: 14X5260] Notice of Realty Action: Modified Competitive Sealed-Bid Sale of Public Land at Schoolhouse...

  1. 76 FR 56793 - Notice of Realty Action: Competitive, Sealed-Bid Sale of Public Lands in Clark County, NV

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... Federal Land Policy and Management Act of 1976 (FLPMA) and applicable BLM land sale and mineral conveyance... listed. The patent, when issued for sale parcel N-85660, will contain a mineral reservation to the United...; TAS: 14X5232] Notice of Realty Action: Competitive, Sealed-Bid Sale of Public Lands in Clark...

  2. 77 FR 13142 - Notice of Realty Action: Modified-Competitive Sale of Public Land in Pahrump, Nye County, NV

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-05

    ... delineating the proposed sale parcel, mineral potential report, EA, and other environmental documents will be...- way as authorized after the sale. Terms and Conditions: Certain minerals for the parcel will be...; TAS: 14X5232] Notice of Realty Action: Modified-Competitive Sale of Public Land in Pahrump, Nye...

  3. 75 FR 65649 - Notice of Realty Action: Segregation To Consider Proposed Sale of Public Lands in Blaine County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-26

    ... Bureau of Land Management Notice of Realty Action: Segregation To Consider Proposed Sale of Public Lands... laws, including the mining laws, except the sale provisions of FLPMA. The BLM is no longer accepting..., publication in the Federal Register of a termination of the segregation, or October 26, 2012 unless...

  4. 77 FR 33235 - Notice of Realty Action: Modified Competitive Sale of Public Lands in Becker County, MN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR Bureau of Land Management Notice of Realty Action: Modified Competitive Sale of Public Lands in Becker County, MN AGENCY: Bureau of Land Management, Interior. ACTION: Notice of realty action. SUMMARY:...

  5. 78 FR 56242 - Notice of Realty Action: Competitive Sale of 28 Parcels of Public Land in Clark County, NV

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-12

    ... Bureau of Land Management [LLNVS00560 L58530000 EU0000 241A; N-78190 et al.; 13-08807; MO 4500053642; TAS: 14X5232] Notice of Realty Action: Competitive Sale of 28 Parcels of Public Land in Clark County, NV AGENCY: Bureau of Land Management, Interior. ACTION: Notice of Realty Action. SUMMARY: The Bureau of...

  6. Goal-Directed Action Representation in Autism

    ERIC Educational Resources Information Center

    Zalla, Tiziana; Labruyere, Nelly; Georgieff, Nicolas

    2006-01-01

    The aim of the present study was to investigate the ability of individuals with autism to represent goal-directed behavioural actions. We compared the performance of subjects with autism (n=16), mentally retarded subjects (n=14) and normal healthy subjects (n=15) in a sequencing task consisted in arranging pictures of single events in their…

  7. Mitigation action plan sale of Naval Petroleum Reserve No. 1 (Elk Hills) Kern County, California

    SciTech Connect

    1998-01-01

    Naval Petroleum Reserve No. 1 (NPR-1, also called {open_quotes}Elk Hills{close_quotes}), a Federally-owned oil and gas production field in Kern County, California, was created by an Executive Order issued by President Taft on September 2, 1912. He signed another Executive Order on December 13, 1912, to establish Naval Petroleum Reserve No. 2 (NPR-2), located immediately south of NPR-1 and containing portions of the town of Taft, California. NPR-1 was not developed until the 1973-74 oil embargo demonstrated the nation`s vulnerability to oil supply interruptions. Following the embargo, Congress passed the Naval Petroleum Reserves Production Act of 1976 which directed that the reserve be explored and developed to its fall economic potential at the {open_quotes}maximum efficient rate{close_quotes} (MER) of production. Since Elk Hills began full production in 1976, it has functioned as a commercial operation, with total revenues to the Federal government through FY 1996 of $16.4 billion, compared to total exploration, development and production costs of $3.1 billion. In February 1996, Title 34 of the National Defense Authorization Act for Fiscal Year 1996 (P.L. 104-106), referred to as the Elk Hills Sales Statute, directed the Secretary of Energy to sell NPR-1 by February 10, 1998.The Secretary was also directed to study options for enhancing the value of the other Naval Petroleum and Oil Shale Reserve properties such as NPR-2, located adjacent to NPR-1 in Kern County- Naval Petroleum Reserve No. 3 (NPR-3) located in Natrona County, Wyoming; Naval Oil Shale Reserves No. 1 and No. 3 (NOSR-1 and NOSR-3) located in Garfield County, Colorado; and Naval Oil Shale Reserve No. 2 (NOSR-2) located in Uintah and Carbon Counties, Utah. The purpose of these actions was to remove the Federal government from the inherently non-Federal function of operating commercial oil fields while making sure that the public would obtain the maximum value from the reserves.

  8. 75 FR 55349 - Notice of Realty Action: Modified Competitive Sealed Bid Sale of Public Lands in Rio Arriba...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-10

    ... in Rio Arriba County, NM AGENCY: Bureau of Land Management, Interior. ACTION: Notice of realty action... Manager, Farmington Field Office, 1235 La Plata Highway, Suite A, Farmington, New Mexico 87401. FOR... described contains 160 acres, more or less, in Rio Arriba County. The sale is in conformance with the...

  9. 75 FR 35832 - Notice of Realty Action: Competitive Sale of Public Lands in Tehama County, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-23

    ... land sale and mineral conveyance regulations. The sales will be conducted as a competitive bid auction.... The lands identified for sale are considered to have no known mineral value except for oil and gas... proposed land sales, including the appraisal, planning and environmental documents, and a mineral...

  10. 29 CFR 42.7 - Complaint/directed action logs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Complaint/directed action logs. 42.7 Section 42.7 Labor Office of the Secretary of Labor COORDINATED ENFORCEMENT § 42.7 Complaint/directed action logs. (a) To... operation of a system of coordinated Complaint/Directed Action Logs (logs). The logs shall be maintained...

  11. 29 CFR 42.7 - Complaint/directed action logs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 1 2013-07-01 2013-07-01 false Complaint/directed action logs. 42.7 Section 42.7 Labor Office of the Secretary of Labor COORDINATED ENFORCEMENT § 42.7 Complaint/directed action logs. (a) To... operation of a system of coordinated Complaint/Directed Action Logs (logs). The logs shall be maintained...

  12. 29 CFR 42.7 - Complaint/directed action logs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 1 2012-07-01 2012-07-01 false Complaint/directed action logs. 42.7 Section 42.7 Labor Office of the Secretary of Labor COORDINATED ENFORCEMENT § 42.7 Complaint/directed action logs. (a) To... operation of a system of coordinated Complaint/Directed Action Logs (logs). The logs shall be maintained...

  13. 29 CFR 42.7 - Complaint/directed action logs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Complaint/directed action logs. 42.7 Section 42.7 Labor Office of the Secretary of Labor COORDINATED ENFORCEMENT § 42.7 Complaint/directed action logs. (a) To... operation of a system of coordinated Complaint/Directed Action Logs (logs). The logs shall be maintained...

  14. 29 CFR 42.7 - Complaint/directed action logs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 1 2011-07-01 2011-07-01 false Complaint/directed action logs. 42.7 Section 42.7 Labor Office of the Secretary of Labor COORDINATED ENFORCEMENT § 42.7 Complaint/directed action logs. (a) To... operation of a system of coordinated Complaint/Directed Action Logs (logs). The logs shall be maintained...

  15. Administrative Actions for Noncompliance; Lesser Administrative Actions. Direct final rule.

    PubMed

    2016-04-01

    The Food and Drug Administration (FDA) is amending the regulation describing lesser administrative actions that may be imposed on an Institutional Review Board (IRB) that has failed to comply with FDA's IRB regulations. We are clarifying that FDA may require the IRB to withhold approval of new FDA-regulated studies, stop the enrollment of new subjects in ongoing studies, and terminate ongoing studies, or any combination of these actions until the noncompliance with FDA's IRB regulations is corrected. We are taking this action to ensure clarity and improve the accuracy of the regulations.

  16. Action Congruency Influences Crowding When Discriminating Biological Motion Direction.

    PubMed

    Ikeda, Hanako; Watanabe, Katsumi

    2016-09-01

    Identification and discrimination of peripheral stimuli are often difficult when a few stimuli adjacent to the target are present (crowding). Our previous study showed that crowding occurs for walking direction discrimination of a biological motion stimulus. In the present study, we attempted to examine whether action congruency between the target and flankers would influence the crowding effect on biological motion stimuli. Each biological motion stimulus comprised one action (e.g., walking, throwing wastepaper, etc.) and was rotated in one of five directions around the vertical axis. In Experiment 1, observers discriminated between the directions of the target stimulus actions, which were surrounded by two flankers in the peripheral visual field. The crowding effect was stronger when the flankers performed the same action as the target and the directions differed. The congruency of action type enhanced the crowding effect in the direction-discrimination task. In Experiment 2, observers discriminated between action types of target stimuli. The crowding effect for the action-discrimination task was not modulated by the congruency of action direction. Thus, identical actions induced a larger crowding effect for action-direction discrimination, but congruent directions did not influence crowding for action-type discrimination. These results suggest that the processes involved in direction discrimination of biological motion are partially distinct from action discrimination processes.

  17. Infants Prefer Motionese to Adult-Directed Action

    ERIC Educational Resources Information Center

    Brand, Rebecca J.; Shallcross, Wendy L.

    2008-01-01

    In two studies, we investigated infants' preference for infant-directed (ID) action or "motionese" (Brand, Baldwin & Ashburn, 2002) relative to adult-directed (AD) action. In Study 1, full-featured videos were shown to 32 6- to 8-month-olds, who demonstrated a strong preference for ID action. In Study 2, infants at 6-8 months (n= 28) and 11-13…

  18. Emotional consequences of collective action participation: differentiating self-directed and outgroup-directed emotions.

    PubMed

    Becker, Julia C; Tausch, Nicole; Wagner, Ulrich

    2011-12-01

    The present research examines the emotional and behavioral consequences of collective action participation. It demonstrates that "positive" and "negative" emotions can be experienced simultaneously as a result of collective action participation, yet it is important to distinguish outgroup-directed from self-directed emotions. Results of two experiments (N = 71 and N = 101) that manipulated participation in collective action illustrate that whereas collective action participants experience more outgroup-directed anger and contempt, they feel more self-directed positive affect. Furthermore, collective action participation predicted willingness to engage in moderate and radical collective actions in the future. These relations were mediated by outgroup-directed, but not by self-directed, emotions, suggesting that outgroup-directed rather than self-directed emotions play a crucial role in the maintenance of protest behavior. Theoretical and practical implications of these findings are discussed. PMID:21737603

  19. Premotor cortex is critical for goal-directed actions

    PubMed Central

    Gremel, Christina M.; Costa, Rui M.

    2013-01-01

    Shifting between motor plans is often necessary for adaptive behavior. When faced with changing consequences of one’s actions, it is often imperative to switch from automatic actions to deliberative and controlled actions. The pre-supplementary motor area (pre-SMA) in primates, akin to the premotor cortex (M2) in mice, has been implicated in motor learning and planning, and action switching. We hypothesized that M2 would be differentially involved in goal-directed actions, which are controlled by their consequences vs. habits, which are more dependent on their past reinforcement history and less on their consequences. To investigate this, we performed M2 lesions in mice and then concurrently trained them to press the same lever for the same food reward using two different schedules of reinforcement that differentially bias towards the use of goal-directed versus habitual action strategies. We then probed whether actions were dependent on their expected consequence through outcome revaluation testing. We uncovered that M2 lesions did not affect the acquisition of lever-pressing. However, in mice with M2 lesions, lever-pressing was insensitive to changes in expected outcome value following goal-directed training. However, habitual actions were intact. We confirmed a role for M2 in goal-directed but not habitual actions in separate groups of mice trained on the individual schedules biasing towards goal-directed versus habitual actions. These data indicate that M2 is critical for actions to be updated based on their consequences, and suggest that habitual action strategies may not require processing by M2 and the updating of motor plans. PMID:23964233

  20. Direct-to-consumer sales of genetic services on the Internet

    PubMed Central

    Gollust, Sarah E.; Wilfond, Benjamin S.; Hull, Sara Chandros

    2016-01-01

    Purpose The increasing use of the Internet to obtain genetics information and to order medical services without a prescription, combined with a rise in direct-to-consumer marketing for genetic testing, suggests the potential for the Internet to be used to sell genetic services. Methods A systematic World Wide Web search was conducted in May 2002 to assess the availability of genetic services sold directly to consumers on the Internet. Results Out of 105 sites that offered genetic services directly, most offered non–health-related services, including parentage confirmation testing (83%), identity testing (56%), and DNA banking (24%); however, health-related genetic tests were offered through 14 sites (13%). The health-related genetic tests available ranged from standard tests, such as hemochromatosis and cystic fibrosis, to more unconventional tests related to nutrition, behavior, and aging. Of these 14 sites, 5 described risks associated with the genetic services and 6 described the availability of counseling. Conclusions The availability of direct sales of health-related genetic tests creates the potential for inadequate pretest decision making, misunderstanding test results, and access to tests of questionable clinical value. PMID:12865763

  1. Direct-to-consumer sales of genetic services on the Internet.

    PubMed

    Gollust, Sarah E; Wilfond, Benjamin S; Hull, Sara Chandros

    2003-01-01

    PURPOSE The increasing use of the Internet to obtain genetics information and to order medical services without a prescription, combined with a rise in direct-to-consumer marketing for genetic testing, suggests the potential for the Internet to be used to sell genetic services. METHODS A systematic World Wide Web search was conducted in May 2002 to assess the availability of genetic services sold directly to consumers on the Internet. RESULTS Out of 105 sites that offered genetic services directly, most offered non-health-related services, including parentage confirmation testing (83%), identity testing (56%), and DNA banking (24%); however, health-related genetic tests were offered through 14 sites (13%). The health-related genetic tests available ranged from standard tests, such as hemochromatosis and cystic fibrosis, to more unconventional tests related to nutrition, behavior, and aging. Of these 14 sites, 5 described risks associated with the genetic services and 6 described the availability of counseling. CONCLUSIONS The availability of direct sales of health-related genetic tests creates the potential for inadequate pretest decision making, misunderstanding test results, and access to tests of questionable clinical value. PMID:12865763

  2. 26 CFR 1.6041A-1 - Returns regarding payments of remuneration for services and certain direct sales.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Returns regarding payments of remuneration for... Returns regarding payments of remuneration for services and certain direct sales. (a) through (c) (d... withholding agent. (B) Returns of information are not required for payments of remuneration for services...

  3. Infants' Understanding of Object-Directed Action: An Interdisciplinary Synthesis.

    PubMed

    Robson, Scott J; Kuhlmeier, Valerie A

    2016-01-01

    Recognizing that the object-directed actions of others are governed by goals and intentions is a crucial component of human interaction. These actions often occur rapidly and without explanation, yet we learn from and predict the actions of others with remarkable speed and accuracy, even during the first year of life. This review paper will serve as a bridge between several disparate literatures that, we suggest, can each contribute to our understanding of how infants interpret action. Specifically, we provide a review not just of research on infant goal attribution per se, but also incorporate findings from studies on the mirror neuron system and infant object cognition. The integration of these various research approaches allows for a novel construal of the extents and limits of early goal attribution - one in which the importance of the entire action context is considered - and points to specific future research directions. PMID:26903918

  4. Infants’ Understanding of Object-Directed Action: An Interdisciplinary Synthesis

    PubMed Central

    Robson, Scott J.; Kuhlmeier, Valerie A.

    2016-01-01

    Recognizing that the object-directed actions of others are governed by goals and intentions is a crucial component of human interaction. These actions often occur rapidly and without explanation, yet we learn from and predict the actions of others with remarkable speed and accuracy, even during the first year of life. This review paper will serve as a bridge between several disparate literatures that, we suggest, can each contribute to our understanding of how infants interpret action. Specifically, we provide a review not just of research on infant goal attribution per se, but also incorporate findings from studies on the mirror neuron system and infant object cognition. The integration of these various research approaches allows for a novel construal of the extents and limits of early goal attribution – one in which the importance of the entire action context is considered – and points to specific future research directions. PMID:26903918

  5. The nature of goal-directed action representations in infancy.

    PubMed

    Sommerville, Jessica A; Upshaw, Michaela B; Loucks, Jeff

    2012-01-01

    A critical question for developmental psychologists concerns how representations in infancy are best characterized. Past and current research provides paradoxical evidence regarding the nature of early representations: in some ways, infants appear to build concrete and specific representations that guide their online perception and understanding of different events; in other ways, infants appear to possess abstract representations that support inferences regarding unseen event outcomes. Characterizing the nature of early representations across domains is a central charge for developmentalists because this task can provide important information regarding the underlying learning process or processes that drive development. Yet, little existing work has attempted to resolve this paradox by characterizing the ways in which infants' representations may have both abstract and concrete elements. The goal of this chapter is to take a close look at infants' early representations of goal-directed action in order to describe the nature of these representations. We first discuss the nature of representations of action that infants build through acting on the world and argue that these representations possess both concrete and abstract elements. On the one hand, infants appear to build representations of action that stress goal-relevant features of actions in an action- or event-specific fashion, suggesting specificity or concreteness. On the other hand, these representations are sufficiently abstract to not only drive action but also support infants' perception of others actions and to support inferences regarding unseen action outcomes. We next discuss evidence to suggest that by the end of the first year of life, infants possess increasingly abstract representations of the actions of others and use contextual cues, including linguistic statements accompanying action, to flexibly specify the level of representational specificity. We further consider the possibility that

  6. The nature of goal-directed action representations in infancy.

    PubMed

    Sommerville, Jessica A; Upshaw, Michaela B; Loucks, Jeff

    2012-01-01

    A critical question for developmental psychologists concerns how representations in infancy are best characterized. Past and current research provides paradoxical evidence regarding the nature of early representations: in some ways, infants appear to build concrete and specific representations that guide their online perception and understanding of different events; in other ways, infants appear to possess abstract representations that support inferences regarding unseen event outcomes. Characterizing the nature of early representations across domains is a central charge for developmentalists because this task can provide important information regarding the underlying learning process or processes that drive development. Yet, little existing work has attempted to resolve this paradox by characterizing the ways in which infants' representations may have both abstract and concrete elements. The goal of this chapter is to take a close look at infants' early representations of goal-directed action in order to describe the nature of these representations. We first discuss the nature of representations of action that infants build through acting on the world and argue that these representations possess both concrete and abstract elements. On the one hand, infants appear to build representations of action that stress goal-relevant features of actions in an action- or event-specific fashion, suggesting specificity or concreteness. On the other hand, these representations are sufficiently abstract to not only drive action but also support infants' perception of others actions and to support inferences regarding unseen action outcomes. We next discuss evidence to suggest that by the end of the first year of life, infants possess increasingly abstract representations of the actions of others and use contextual cues, including linguistic statements accompanying action, to flexibly specify the level of representational specificity. We further consider the possibility that

  7. Child-directed action promotes 2-year-olds' imitation.

    PubMed

    Williamson, Rebecca A; Brand, Rebecca J

    2014-02-01

    Children are voracious learners and adults are ubiquitous teachers. This project investigated whether the special infant-directed action modifications parents use when teaching their children (called "motionese" by Brand et al., Developmental Science, 2002, Vol. 5, pp. 72-83) improves 2-year-olds' imitation. Children saw an adult perform a series of acts on four novel objects using either an infant-directed style (including larger range of motion and enhanced boundary marking) or an adult-directed style. Children's imitation of the acts was higher in the infant-directed condition relative to the adult-directed condition, and both types of demonstration increased imitation relative to baseline (no demonstration). We propose that motionese provides information about actions, objects, and intentionality, thereby enhancing toddlers' observational learning.

  8. Global Reach of Direct-to-Consumer Advertising Using Social Media for Illicit Online Drug Sales

    PubMed Central

    Liang, Bryan A

    2013-01-01

    Background Illicit or rogue Internet pharmacies are a recognized global public health threat that have been identified as utilizing various forms of online marketing and promotion, including social media. Objective To assess the accessibility of creating illicit no prescription direct-to-consumer advertising (DTCA) online pharmacy social media marketing (eDTCA2.0) and evaluate its potential global reach. Methods We identified the top 4 social media platforms allowing eDTCA2.0. After determining applicable platforms (ie, Facebook, Twitter, Google+, and MySpace), we created a fictitious advertisement advertising no prescription drugs online and posted it to the identified social media platforms. Each advertisement linked to a unique website URL that consisted of a site error page. Employing Web search analytics, we tracked the number of users visiting these sites and their location. We used commercially available Internet tools and services, including website hosting, domain registration, and website analytic services. Results Illicit online pharmacy social media content for Facebook, Twitter, and MySpace remained accessible despite highly questionable and potentially illegal content. Fictitious advertisements promoting illicit sale of drugs generated aggregate unique user traffic of 2795 visits over a 10-month period. Further, traffic to our websites originated from a number of countries, including high-income and middle-income countries, and emerging markets. Conclusions Our results indicate there are few barriers to entry for social media–based illicit online drug marketing. Further, illicit eDTCA2.0 has globalized outside US borders to other countries through unregulated Internet marketing. PMID:23718965

  9. Direct and indirect dorsolateral striatum pathways reinforce different action strategies.

    PubMed

    Vicente, Ana M; Galvão-Ferreira, Pedro; Tecuapetla, Fatuel; Costa, Rui M

    2016-04-01

    The basal ganglia, and the striatum in particular, are critical for action reinforcement [1,2]. The dorsal striatum, which can be further subdivided into dorsomedial (DMS) and dorsolateral (DLS) striatum, is mainly composed of two subpopulations of striatal medium spiny projection neurons (MSNs): dopamine D1 receptor-expressing MSNs that constitute the striatonigral or direct pathway (dMSNs); and dopamine D2 receptor-expressing MSNs that constitute the striatopallidal or indirect pathway (iMSNs) [3]. It has been suggested that each pathway has opposing roles in reinforcement, with dMSNs being important to learn positive reinforcement and iMSNs to learn to avoid undesired actions (Go/No-Go) [1]. Furthermore, optogenetic self-stimulation of dMSNs in DMS leads to reinforcement of actions, while self-stimulation of iMSNs leads to avoidance of actions [2]. However, in DLS, which has been implicated in the consolidation of well-trained actions and habits in mice [4,5], both pathways are active during lever-pressing for reward [6]. Furthermore, extensive skill training leads to long-lasting potentiation of glutamatergic inputs into both dMSNs and iMSNs [4]. We report here that, in DLS, both dMSNs and iMSNs are involved in positive reinforcement, but support different action strategies. PMID:27046807

  10. Training and Work Organisation: An Action-Research Study in a Sales and Distribution Company

    ERIC Educational Resources Information Center

    Bernardes, Alda Cristina; Lopes, Albino Pedro

    2005-01-01

    This study seeks to define a method of designing work-linked training, based on day-to-day work practices and the collaboration between all those involved. From diagnosis to evaluation, no training is designed or given without considering the opinions and interests of the parties involved. The method used is based on action research (AR) and on…

  11. A tobacco-free world: a call to action to phase out the sale of tobacco products by 2040.

    PubMed

    Beaglehole, Robert; Bonita, Ruth; Yach, Derek; Mackay, Judith; Reddy, K Srinath

    2015-03-14

    The time has come for the world to acknowledge the unacceptability of the damage being done by the tobacco industry and work towards a world essentially free from the sale (legal and illegal) of tobacco products. A tobacco-free world by 2040, where less than 5% of the world's adult population use tobacco, is socially desirable, technically feasible, and could become politically practical. Three possible ways forward exist: so-called business-as-usual, with most countries steadily implementing the WHO Framework Convention on Tobacco Control (FCTC) provisions; accelerated implementation of the FCTC by all countries; and a so-called turbo-charged approach that complements FCTC actions with strengthened UN leadership, full engagement of all sectors, and increased investment in tobacco control. Only the turbo-charged approach will achieve a tobacco-free world by 2040 where tobacco is out of sight, out of mind, and out of fashion--yet not prohibited. The first and most urgent priority is the inclusion of an ambitious tobacco target in the post-2015 sustainable development health goal. The second priority is accelerated implementation of the FCTC policies in all countries, with full engagement from all sectors including the private sector--from workplaces to pharmacies--and with increased national and global investment. The third priority is an amendment of the FCTC to include an ambitious global tobacco reduction goal. The fourth priority is a UN high-level meeting on tobacco use to galvanise global action towards the 2040 tobacco-free world goal on the basis of new strategies, new resources, and new players. Decisive and strategic action on this bold vision will prevent hundreds of millions of unnecessary deaths during the remainder of this century and safeguard future generations from the ravages of tobacco use.

  12. Response actions influence the categorization of directions in auditory space.

    PubMed

    Velten, Marcella C C; Bläsing, Bettina E; Hermann, Thomas; Vorwerg, Constanze; Schack, Thomas

    2015-01-01

    Spatial region concepts such as "front," "back," "left," and "right" reflect our typical interaction with space, and the corresponding surrounding regions have different statuses in memory. We examined the representation of spatial directions in the auditory space, specifically in how far natural response actions, such as orientation movements toward a sound source, would affect the categorization of egocentric auditory space. While standing in the middle of a circle with 16 loudspeakers, participants were presented acoustic stimuli coming from the loudspeakers in randomized order, and verbally described their directions by using the concept labels "front," "back," "left," "right," "front-right," "front-left," "back-right," and "back-left." Response actions varied in three blocked conditions: (1) facing front, (2) turning the head and upper body to face the stimulus, and (3) turning the head and upper body plus pointing with the hand and outstretched arm toward the stimulus. In addition to a protocol of the verbal utterances, motion capture and video recording generated a detailed corpus for subsequent analysis of the participants' behavior. Chi-square tests revealed an effect of response condition for directions within the left and right sides. We conclude that movement-based response actions influence the representation of auditory space, especially within the sides' regions. Moreover, the representation of auditory space favors the front and the back regions in terms of resolution, which is possibly related to the physiological characteristics of the human auditory system, as well as to the ecological requirements of action control in the different regions. PMID:26300837

  13. Response actions influence the categorization of directions in auditory space

    PubMed Central

    Velten, Marcella C. C.; Bläsing, Bettina E.; Hermann, Thomas; Vorwerg, Constanze; Schack, Thomas

    2015-01-01

    Spatial region concepts such as “front,” “back,” “left,” and “right” reflect our typical interaction with space, and the corresponding surrounding regions have different statuses in memory. We examined the representation of spatial directions in the auditory space, specifically in how far natural response actions, such as orientation movements toward a sound source, would affect the categorization of egocentric auditory space. While standing in the middle of a circle with 16 loudspeakers, participants were presented acoustic stimuli coming from the loudspeakers in randomized order, and verbally described their directions by using the concept labels “front,” “back,” “left,” “right,” “front-right,” “front-left,” “back-right,” and “back-left.” Response actions varied in three blocked conditions: (1) facing front, (2) turning the head and upper body to face the stimulus, and (3) turning the head and upper body plus pointing with the hand and outstretched arm toward the stimulus. In addition to a protocol of the verbal utterances, motion capture and video recording generated a detailed corpus for subsequent analysis of the participants’ behavior. Chi-square tests revealed an effect of response condition for directions within the left and right sides. We conclude that movement-based response actions influence the representation of auditory space, especially within the sides’ regions. Moreover, the representation of auditory space favors the front and the back regions in terms of resolution, which is possibly related to the physiological characteristics of the human auditory system, as well as to the ecological requirements of action control in the different regions. PMID:26300837

  14. Human and Rodent Homologies in Action Control: Corticostriatal Determinants of Goal-Directed and Habitual Action

    PubMed Central

    Balleine, Bernard W; O'Doherty, John P

    2010-01-01

    Recent behavioral studies in both humans and rodents have found evidence that performance in decision-making tasks depends on two different learning processes; one encoding the relationship between actions and their consequences and a second involving the formation of stimulus–response associations. These learning processes are thought to govern goal-directed and habitual actions, respectively, and have been found to depend on homologous corticostriatal networks in these species. Thus, recent research using comparable behavioral tasks in both humans and rats has implicated homologous regions of cortex (medial prefrontal cortex/medial orbital cortex in humans and prelimbic cortex in rats) and of dorsal striatum (anterior caudate in humans and dorsomedial striatum in rats) in goal-directed action and in the control of habitual actions (posterior lateral putamen in humans and dorsolateral striatum in rats). These learning processes have been argued to be antagonistic or competing because their control over performance appears to be all or none. Nevertheless, evidence has started to accumulate suggesting that they may at times compete and at others cooperate in the selection and subsequent evaluation of actions necessary for normal choice performance. It appears likely that cooperation or competition between these sources of action control depends not only on local interactions in dorsal striatum but also on the cortico-basal ganglia network within which the striatum is embedded and that mediates the integration of learning with basic motivational and emotional processes. The neural basis of the integration of learning and motivation in choice and decision-making is still controversial and we review some recent hypotheses relating to this issue. PMID:19776734

  15. 78 FR 13079 - Notice of Realty Action: Modified Competitive Sale of Public Land in Marquette County, Michigan

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-26

    ... question with the above individual. You will receive a reply during normal business hours. SUPPLEMENTARY... preference consideration offered by the modified competitive sale and no successful bid is received, then the... time, at the BLM, Northeastern States Field Office, until a successful bid is received or the sale...

  16. Action Recognition and Movement Direction Discrimination Tasks Are Associated with Different Adaptation Patterns.

    PubMed

    de la Rosa, Stephan; Ekramnia, Mina; Bülthoff, Heinrich H

    2016-01-01

    The ability to discriminate between different actions is essential for action recognition and social interactions. Surprisingly previous research has often probed action recognition mechanisms with tasks that did not require participants to discriminate between actions, e.g., left-right direction discrimination tasks. It is not known to what degree visual processes in direction discrimination tasks are also involved in the discrimination of actions, e.g., when telling apart a handshake from a high-five. Here, we examined whether action discrimination is influenced by movement direction and whether direction discrimination depends on the type of action. We used an action adaptation paradigm to target action and direction discrimination specific visual processes. In separate conditions participants visually adapted to forward and backward moving handshake and high-five actions. Participants subsequently categorized either the action or the movement direction of an ambiguous action. The results showed that direction discrimination adaptation effects were modulated by the type of action but action discrimination adaptation effects were unaffected by movement direction. These results suggest that action discrimination and direction categorization rely on partly different visual information. We propose that action discrimination tasks should be considered for the exploration of visual action recognition mechanisms.

  17. 78 FR 25097 - Notice of Realty Action: Competitive, Sealed-Bid, Spring SNPLMA Sale of Public Lands in Clark...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-29

    ... Environmental Policy Act Adequacy (DNA). DATES: Interested parties may submit written comments regarding the... specific DNA document numbered DOI-BLM-NV-S010-2012-0106-DNA. Sale procedures: Sealed bids must...

  18. 78 FR 64974 - Notice of Realty Action; Modified Competitive Sealed-Bid Sale of Public Land at Schoolhouse Butte...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-30

    ... sealed bids for this public land sale. The original notice, which published on September 25, 2013 (78 FR 59055), incorrectly stated the date. On page 59055, column 2, line 4 below the chart, which...

  19. 76 FR 29784 - Notice of Realty Action; Direct Sale of Public Lands in Jerome County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-23

    ... owners of the adjacent private land, Todd and Bridget Buschhorn, for the appraised fair market value of... than the appraised fair market value: Boise Meridian T. 10 S., R. 19 E., sec. 25, lot 10. The area described contains 7.45 acres in Jerome County. The appraised fair market value is $5,600. The public...

  20. 76 FR 2413 - Notice of Realty Action: Direct Sale of Public Land in Lawrence County, SD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-13

    ... Dakota Field Office, 310 Roundup Street, Belle Fourche, South Dakota 57717. FOR FURTHER INFORMATION CONTACT: Charles Berdan, Realty Specialist, BLM, South Dakota Field Office, 310 Roundup Street,...

  1. 75 FR 80839 - Notice of Realty Action: Direct Sale of Public Lands in Lane County, OR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-23

    ... Determination of National Environmental Policy Act Adequacy (DOI-BLM-OR-E050-2010-0006- DNA) that was approved... Determination of NEPA Adequacy (DOI-BLM-OR-E050-2010-0006- DNA), EA (EA OR-090-97-42), Decision Record, map,...

  2. 75 FR 39580 - Notice of Realty Action; Direct Sale of Public Lands in Minidoka County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-09

    ...The Bureau of Land Management (BLM) proposes to sell four parcels of public land totaling 262.11 acres in Minidoka County, Idaho, to the owners of the surrounding private land for the appraised fair market value of $85,200. The private land surrounding the public land is owned by the Western Mortgage and Realty...

  3. 75 FR 80841 - Notice of Realty Action: Direct Sale of Public Land in Kern County, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-23

    ...The Bureau of Land Management (BLM), Ridgecrest Field Office, proposes to sell a parcel of public land consisting of 160 acres in Kern County, California to the County of Kern for the appraised fair market value of...

  4. 75 FR 71143 - Notice of Realty Action: Direct Sale of Public Land in Blaine County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-22

    ... Animal Shelter of Wood River Valley (Animal Shelter) for the appraised fair market value of $18,700.... The Animal Shelter is a non-profit corporation that provides public benefits to Blaine County (County.... The Animal Shelter was issued a right-of-way for a road and a fence that cross the 17-acre...

  5. 75 FR 22625 - Notice of Realty Action; Direct Sale of Public Land in Jerome County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-29

    ... FURTHER INFORMATION CONTACT: Lisa Claxton, Natural Resource Specialist, at the above address or phone (208... 1985 BLM Monument Resource Management Plan, as amended by the 2003 Amendments to BLM Shoshone...

  6. Luteinizing hormone: Evidence for direct action in the CNS.

    PubMed

    Blair, Jeffrey A; Bhatta, Sabina; McGee, Henry; Casadesus, Gemma

    2015-11-01

    This article is part of a Special Issue "SBN 2014". Hormonal dysfunction due to aging, especially during menopause, plays a substantial role in cognitive decline as well as the progression and development of neurodegenerative diseases. The hypothalamic-pituitary-gonadal (HPG) axis has long been implicated in changes in behavior and neuronal morphology. Most notably, estrogens have proven beneficial in the healthy brain through a host of different mechanisms. Recently, luteinizing hormone (LH) has emerged as a candidate for further investigation for its role in the CNS. The basis of this is that both LH and the LH receptor are expressed in the brain, and serum levels of LH correlate with cognitive deficits and Alzheimer's disease (AD) incidence. The study of LH in cognition and AD primarily focuses on evaluating the effects of downregulation of this peptide. This literature has shown that decreasing peripheral LH, through a variety of pharmacological interventions, reduces cognitive deficits in ovariectomy and AD models. However, few studies have researched the direct actions of LH on neurons and glial cells. Here we summarize the role of luteinizing hormone in modulating cognition, and we propose a mechanism that underlies a role for brain LH in this process.

  7. 76 FR 6154 - Notice of Realty Action: Modified Competitive Bid Sale of Public Lands in Santa Cruz County, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... government. It is the buyer's responsibility to be aware of all applicable local government policies, laws... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR... sale in accordance with Sections 203 and 209 of the Federal Land Policy and Management Act (FLPMA)...

  8. 14 CFR 39.11 - What actions do airworthiness directives require?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false What actions do airworthiness directives require? 39.11 Section 39.11 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS DIRECTIVES § 39.11 What actions do airworthiness directives...

  9. Infants' Perception of Goal-Directed Actions on Video

    ERIC Educational Resources Information Center

    Hofer, Tanja; Hauf, Petra; Aschersleben, Gisa

    2007-01-01

    Imitation studies and object search studies show that infants have difficulties using action information presented on video to guide their own behaviour. The present study investigated whether infants also have problems interpreting information shown on video relative to real live information. It was examined whether 6-month-olds interpret an…

  10. 12 CFR 308.201 - Directives to take prompt corrective action.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Directives to take prompt corrective action. 308.201 Section 308.201 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF... Action Provisions of the Federal Deposit Insurance Act § 308.201 Directives to take prompt...

  11. 10 CFR 205.14 - Ratification of prior directives, orders, and actions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Ratification of prior directives, orders, and actions. 205.14 Section 205.14 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS General Provisions § 205.14 Ratification of prior directives, orders, and actions. All interpretations,...

  12. Target- and Effect-Directed Actions towards Temporal Goals: Similar Mechanisms?

    ERIC Educational Resources Information Center

    Walter, Andrea M.; Rieger, Martina

    2012-01-01

    The goal of an action can consist of generating a change in the environment (to produce an effect) or changing one's own situation in the environment (to move to a physical target). To investigate whether the mechanisms of effect-directed and target-directed action control are similar, participants performed continuous reversal movements. They…

  13. Enhancing the Professional Mindset of Future Sales Professionals: Key Insights from a Master in Sales Transformation

    ERIC Educational Resources Information Center

    Marcos-Cuevas, Javier; Critten, Peter; Squire, Phil; Speakman, James I. F.

    2014-01-01

    Sales education has grown in importance, particularly throughout the last decade, with an increasing number of university sales centers offering programs to prepare new generations of sales professionals. In this article, we describe how work-based learning, action research, and reflective practice used in a sales master program can be used in…

  14. The time course of direction specification in brief interceptive actions.

    PubMed

    Marinovic, Welber; Plooy, Annaliese M; Tresilian, James R

    2010-01-01

    In fastball sports such as baseball and tennis people are required to produce accurate responses following brief observations of the ball. This limits the time available to prepare the movement. To cope with constrained viewing periods which precede the interception of fast approaching balls, performers are likely to prepare their responses in advance. Although motor preparation may begin before the moving object is seen, accuracy requires that certain program parameters are determined from observations of the target. The aim of the experiment reported here was to determine the last moment at which information about the direction of the target can be incorporated into a motor program. The empirical protocol used in this study allowed us to examine whether new direction information is incorporated discretely or continuously into the program during short intervals prior to movement onset (MO) - the preparation interval. Participants were trained to hit moving targets at two directions with movements of a specific duration (180 ms). This method permitted an estimate of MO. Preparation intervals were controlled by issuing a stimulus cue for movement direction at various times prior to the estimated MO. Results showed that direction information could be fully incorporated into the program with a preparation interval as brief as 250 ms. In addition, the results indicated that direction was specified predominantly in a discrete fashion even at short preparation intervals. PMID:20178919

  15. The time course of direction specification in brief interceptive actions.

    PubMed

    Marinovic, Welber; Plooy, Annaliese M; Tresilian, James R

    2010-01-01

    In fastball sports such as baseball and tennis people are required to produce accurate responses following brief observations of the ball. This limits the time available to prepare the movement. To cope with constrained viewing periods which precede the interception of fast approaching balls, performers are likely to prepare their responses in advance. Although motor preparation may begin before the moving object is seen, accuracy requires that certain program parameters are determined from observations of the target. The aim of the experiment reported here was to determine the last moment at which information about the direction of the target can be incorporated into a motor program. The empirical protocol used in this study allowed us to examine whether new direction information is incorporated discretely or continuously into the program during short intervals prior to movement onset (MO) - the preparation interval. Participants were trained to hit moving targets at two directions with movements of a specific duration (180 ms). This method permitted an estimate of MO. Preparation intervals were controlled by issuing a stimulus cue for movement direction at various times prior to the estimated MO. Results showed that direction information could be fully incorporated into the program with a preparation interval as brief as 250 ms. In addition, the results indicated that direction was specified predominantly in a discrete fashion even at short preparation intervals.

  16. Direct action of endocrine disrupting chemicals on human sperm.

    PubMed

    Schiffer, Christian; Müller, Astrid; Egeberg, Dorte L; Alvarez, Luis; Brenker, Christoph; Rehfeld, Anders; Frederiksen, Hanne; Wäschle, Benjamin; Kaupp, U Benjamin; Balbach, Melanie; Wachten, Dagmar; Skakkebaek, Niels E; Almstrup, Kristian; Strünker, Timo

    2014-07-01

    Synthetic endocrine disrupting chemicals (EDCs), omnipresent in food, household, and personal care products, have been implicated in adverse trends in human reproduction, including infertility and increasing demand for assisted reproduction. Here, we study the action of 96 ubiquitous EDCs on human sperm. We show that structurally diverse EDCs activate the sperm-specific CatSper channel and, thereby, evoke an intracellular Ca(2+) increase, a motility response, and acrosomal exocytosis. Moreover, EDCs desensitize sperm for physiological CatSper ligands and cooperate in low-dose mixtures to elevate Ca(2+) levels in sperm. We conclude that EDCs interfere with various sperm functions and, thereby, might impair human fertilization. PMID:24820036

  17. Direct action of endocrine disrupting chemicals on human sperm

    PubMed Central

    Schiffer, Christian; Müller, Astrid; Egeberg, Dorte L; Alvarez, Luis; Brenker, Christoph; Rehfeld, Anders; Frederiksen, Hanne; Wäschle, Benjamin; Kaupp, U Benjamin; Balbach, Melanie; Wachten, Dagmar; Skakkebaek, Niels E; Almstrup, Kristian; Strünker, Timo

    2014-01-01

    Synthetic endocrine disrupting chemicals (EDCs), omnipresent in food, household, and personal care products, have been implicated in adverse trends in human reproduction, including infertility and increasing demand for assisted reproduction. Here, we study the action of 96 ubiquitous EDCs on human sperm. We show that structurally diverse EDCs activate the sperm-specific CatSper channel and, thereby, evoke an intracellular Ca2+ increase, a motility response, and acrosomal exocytosis. Moreover, EDCs desensitize sperm for physiological CatSper ligands and cooperate in low-dose mixtures to elevate Ca2+ levels in sperm. We conclude that EDCs interfere with various sperm functions and, thereby, might impair human fertilization. PMID:24820036

  18. 7 CFR 930.16 - Sales constituency.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Sales constituency. 930.16 Section 930.16 Agriculture... Definitions § 930.16 Sales constituency. Sales constituency means a common marketing organization or brokerage... consignments of cherries and does not direct where the consigned cherries are sold is not a sales constituency....

  19. 7 CFR 930.16 - Sales constituency.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Sales constituency. 930.16 Section 930.16 Agriculture... Definitions § 930.16 Sales constituency. Sales constituency means a common marketing organization or brokerage... consignments of cherries and does not direct where the consigned cherries are sold is not a sales constituency....

  20. Target- and effect-directed actions towards temporal goals: similar mechanisms?

    PubMed

    Walter, Andrea M; Rieger, Martina

    2012-08-01

    The goal of an action can consist of generating a change in the environment (to produce an effect) or changing one's own situation in the environment (to move to a physical target). To investigate whether the mechanisms of effect-directed and target-directed action control are similar, participants performed continuous reversal movements. They either synchronized movement reversals with regularly presented tones (temporal targets) or produced tones at reversals isochronously (temporal effects). In both goal conditions an irrelevant goal characteristic was integrated into the goal representation (loudness, Experiment 1). When targets and effects were presented within the same reversal movement, similarities were enhanced (Experiment 2). When the task posed spatial demands in addition to temporal demands, target- and effect-directed movement kinematics changed equally with tempo (Experiment 3). Correlations between target-directed and effect-directed movements in temporal variability indicated similar timing mechanisms (Experiments 1 and 2). Only gradual differences between target- and effect-directed movements were observed. We conclude that the same mechanisms of action control, including the anticipation of upcoming events, underlie effect-directed and target-directed movements. Ideomotor theories of action control should incorporate action targets as goals similar to action effects. PMID:22686693

  1. Intentional Forgetting of Actions: Comparison of List-Method and Item-Method Directed Forgetting

    ERIC Educational Resources Information Center

    Sahakyan, Lili; Foster, Nathaniel L.

    2009-01-01

    Performing action phrases (subject-performed tasks, SPTs) leads to better memory than verbal learning instructions (verbal tasks, VTs). In Experiments 1-3, the list-method directed forgetting design produced equivalent directed forgetting impairment for VTs and SPTs; however, directed forgetting enhancement emerged only for VTs, but not SPTs.…

  2. Testing of Action of Direct Flame on Concrete

    PubMed Central

    Valek, Jaroslav; Novosad, Petr

    2015-01-01

    The paper states results of experimental exposition of concrete test specimens to direct flame. Concrete test specimens made from various mixtures differing in the type of aggregate, binder, dispersed reinforcement, and technological procedure were subjected to thermal load. Physicomechanical and other properties of all test specimens were tested before exposition to open flame: density, compressive strength, flexural strength, moisture content, and surface appearance. The specimens were visually observed during exposition to open flame and changes were recorded. Exposed surface was photographically documented before thermal load and at 10-minute intervals. Development of temperature of the specimens was documented with a thermocamera. After exposition to thermal load and cooling down, concrete specimens were visually observed, network of cracks was photographically documented, and maximal depth of spalled area was measured. PMID:25830162

  3. Fathers Show Modifications of Infant-Directed Action Similar to that of Mothers

    ERIC Educational Resources Information Center

    Rutherford, M. D.; Przednowek, Malgorzata

    2012-01-01

    Mothers' actions are more enthusiastic, simple, and repetitive when demonstrating novel object properties to their infants than to adults, a behavioral modification called "infant-directed action" by Brand and colleagues (2002). The current study tested whether fathers also tailor their behavior when interacting with infants and whether this…

  4. A distributed network critical for selecting among tool-directed actions.

    PubMed

    Watson, Christine E; Buxbaum, Laurel J

    2015-04-01

    Tools pose a challenge to the need to select actions appropriate for task goals and environmental constraints. For many tools (e.g., calculator), actions for "using" and "grasping-to-move" conflict with each other and may compete during selection. To date, little is known about the mechanisms that enable selection between possible tool actions or their neural substrates. The study of patients with chronic left hemisphere stroke, many of whom are deficient in tool-use action (apraxic), provides an opportunity to elucidate these issues. Here, 31 such patients pantomimed or recognized tool use actions for "conflict" and "non-conflict" tools. Voxel-based lesion-symptom mapping (VLSM), lesion subtraction, and tractographic overlap analyses were used to determine brain regions necessary for selecting among tool-directed actions. Lesions to posterior middle temporal gyrus (pMTG) and anterior intraparietal sulcus (aIPS) tended to impair production of use actions similarly for both conflict and non-conflict tools. By contrast, lesions to the supramarginal gyrus (SMG), inferior frontal gyrus (IFG)/anterior insula, and superior longitudinal fasciculus (SLF) specifically impaired production of use actions for conflict tools. Patients' errors on conflict tools suggested inappropriate selection of grasping actions and difficulty selecting single actions. Use/grasp conflict had no effect on action recognition. We suggest that the SMG/SLF/IFG pathway implements biased competition between possible tool actions, while aIPS and pMTG compute the structure-based and skilled use actions, respectively, that constitute input to this competitive process. This is the first study to demonstrate a reliable link between a characteristic of single tools (i.e., their association with different use and grasp actions) and action selection difficulties. Additionally, the data allow us to posit an SMG-involved subtype of apraxia characterized by an inability to resolve action competition.

  5. A Distributed Network Critical for Selecting Among Tool-Directed Actions

    PubMed Central

    Watson, Christine E.; Buxbaum, Laurel J.

    2015-01-01

    Tools pose a challenge to the need to select actions appropriate for task goals and environmental constraints. For many tools (e.g., calculator), actions for “using” and “grasping-to-move” conflict with each other and may compete during selection. To date, little is known about the mechanisms that enable selection between possible tool actions or their neural substrates. The study of patients with chronic left hemisphere stroke, many of whom are deficient in tool-use action (apraxic), provides an opportunity to elucidate these issues. Here, 31 such patients pantomimed or recognized tool use actions for “conflict” and “non-conflict” tools. Voxel-based lesion-symptom mapping, lesion subtraction, and tractographic overlap analyses were used to determine brain regions necessary for selecting among tool-directed actions. Lesions to posterior middle temporal gyrus (pMTG) and anterior intraparietal sulcus (aIPS) tended to impair production of use actions similarly for both conflict and non-conflict tools. By contrast, lesions to the supramarginal gyrus (SMG), inferior frontal gyrus (IFG)/anterior insula, and superior longitudinal fasciculus (SLF) specifically impaired production of use actions for conflict tools. Patients' errors on conflict tools suggested inappropriate selection of grasping actions and difficulty selecting single actions. Use/grasp conflict had no effect on action recognition. We suggest that the SMG/SLF/IFG pathway implements biased competition between possible tool actions, while aIPS and pMTG compute the structure-based and skilled use actions, respectively, that constitute input to this competitive process. This is the first study to demonstrate a reliable link between a characteristic of single tools (i.e., their association with different use and grasp actions) and action selection difficulties. Additionally, the data allow us to posit a SMG-involved subtype of apraxia characterized by an inability to resolve action competition

  6. Impact of semantic similarity in novel associations: Direct and indirect routes to action.

    PubMed

    Macdonald, Scott N; Richards, Eric D; Desmarais, Geneviève

    2016-01-01

    Actions produced in response to familiar objects are predominantly mediated by the visual structure of objects, and less so by their semantic associations. Choosing an action in response to an object tends to be faster than choosing the object's name, leading to the suggestion that there are direct links between the visual representations of objects and their actions. The relative contribution of semantics, however, is unclear when actions are produced in response to novel objects. To investigate the role of semantics when object-action associations are novel, we had participants learn to use and name novel objects and rehearse the object, action, and name associations over one week. Each object-action pair was associated with a label that was either semantically similar or semantically distinct. We found that semantic similarity only affected action and name production when the object associations were novel, suggesting that semantic information is recruited when actions are produced in response to novel objects. We also observed that the advantage to producing an action was absent when associations were novel, suggesting that practice is necessary for these direct links to develop. PMID:26704564

  7. Direct Antiangiogenic Actions of Cadmium on Human Vascular Endothelial Cells*

    PubMed Central

    Woods, J. M.; Leone, M.; Klosowska, K.; Lamar, P. C.; Shaknovsky, T. J.; Prozialeck, W. C.

    2008-01-01

    The vascular endothelium is a primary target of cadmium (Cd) toxicity, but little is known regarding a potential mechanism whereby Cd may inhibit angiogenesis. Recent findings showing that Cd can disrupt cadherin-mediated cell-cell adhesion suggested that Cd might inhibit angiogenesis by altering the function of VE-cadherin, a molecule that is essential for angiogenesis. To address this issue, endothelial cells (ECs) were exposed to Cd in the presence of serum and subjected to angiogenesis-related cell migration and tube formation assays. Initial examination of cytotoxicity showed that ECs are rather resistant to the acute cytotoxic effects of Cd even at concentrations up to 1mM. However, 10μM Cd decreased migration of ECs. Cd concentrations of 500nM and greater significantly reduced organization of microvascular ECs into tubes. These antiangiogenic effects were evident even when ECs were preincubated with Cd and then washed to remove free Cd, indicating that Cd acted directly on the cells rather than on the extracellular matrix. Immunolocalization studies showed that Cd caused the redistribution of VE-cadherin from cell-cell contacts. These findings indicate that Cd acts in an angiostatic manner on ECs, and that this effect may involve alterations in the localization and function of VE cadherin. PMID:18243643

  8. Interaction in planning movement direction for articulatory gestures and manual actions.

    PubMed

    Vainio, Lari; Tiainen, Mikko; Tiippana, Kaisa; Komeilipoor, Naeem; Vainio, Martti

    2015-10-01

    Some theories concerning speech mechanisms assume that overlapping representations are involved in programming certain articulatory gestures and hand actions. The present study investigated whether planning of movement direction for articulatory gestures and manual actions could interact. The participants were presented with written vowels (Experiment 1) or syllables (Experiment 2) that were associated with forward or backward movement of tongue (e.g., [i] vs. [ɑ] or [te] vs. [ke], respectively). They were required to pronounce the speech unit and simultaneously move the joystick forward or backward according to the color of the stimulus. Manual and vocal responses were performed relatively rapidly when the articulation and the hand action required movement into the same direction. The study suggests that planning horizontal tongue movements for articulation shares overlapping neural mechanisms with planning horizontal movement direction of hand actions. PMID:26126804

  9. Action Video Games Improve Direction Discrimination of Parafoveal Translational Global Motion but Not Reaction Times.

    PubMed

    Pavan, Andrea; Boyce, Matthew; Ghin, Filippo

    2016-10-01

    Playing action video games enhances visual motion perception. However, there is psychophysical evidence that action video games do not improve motion sensitivity for translational global moving patterns presented in fovea. This study investigates global motion perception in action video game players and compares their performance to that of non-action video game players and non-video game players. Stimuli were random dot kinematograms presented in the parafovea. Observers discriminated the motion direction of a target random dot kinematogram presented in one of the four visual quadrants. Action video game players showed lower motion coherence thresholds than the other groups. However, when the task was performed at threshold, we did not find differences between groups in terms of distributions of reaction times. These results suggest that action video games improve visual motion sensitivity in the near periphery of the visual field, rather than speed response. PMID:27495185

  10. Action Video Games Improve Direction Discrimination of Parafoveal Translational Global Motion but Not Reaction Times.

    PubMed

    Pavan, Andrea; Boyce, Matthew; Ghin, Filippo

    2016-10-01

    Playing action video games enhances visual motion perception. However, there is psychophysical evidence that action video games do not improve motion sensitivity for translational global moving patterns presented in fovea. This study investigates global motion perception in action video game players and compares their performance to that of non-action video game players and non-video game players. Stimuli were random dot kinematograms presented in the parafovea. Observers discriminated the motion direction of a target random dot kinematogram presented in one of the four visual quadrants. Action video game players showed lower motion coherence thresholds than the other groups. However, when the task was performed at threshold, we did not find differences between groups in terms of distributions of reaction times. These results suggest that action video games improve visual motion sensitivity in the near periphery of the visual field, rather than speed response.

  11. The Representation of Object-Directed Action and Function Knowledge in the Human Brain.

    PubMed

    Chen, Quanjing; Garcea, Frank E; Mahon, Bradford Z

    2016-04-01

    The appropriate use of everyday objects requires the integration of action and function knowledge. Previous research suggests that action knowledge is represented in frontoparietal areas while function knowledge is represented in temporal lobe regions. Here we used multivoxel pattern analysis to investigate the representation of object-directed action and function knowledge while participants executed pantomimes of familiar tool actions. A novel approach for decoding object knowledge was used in which classifiers were trained on one pair of objects and then tested on a distinct pair; this permitted a measurement of classification accuracy over and above object-specific information. Region of interest (ROI) analyses showed that object-directed actions could be decoded in tool-preferring regions of both parietal and temporal cortex, while no independently defined tool-preferring ROI showed successful decoding of object function. However, a whole-brain searchlight analysis revealed that while frontoparietal motor and peri-motor regions are engaged in the representation of object-directed actions, medial temporal lobe areas in the left hemisphere are involved in the representation of function knowledge. These results indicate that both action and function knowledge are represented in a topographically coherent manner that is amenable to study with multivariate approaches, and that the left medial temporal cortex represents knowledge of object function. PMID:25595179

  12. Translational studies of goal-directed action as a framework for classifying deficits across psychiatric disorders

    PubMed Central

    Griffiths, Kristi R.; Morris, Richard W.; Balleine, Bernard W.

    2014-01-01

    The ability to learn contingencies between actions and outcomes in a dynamic environment is critical for flexible, adaptive behavior. Goal-directed actions adapt to changes in action-outcome contingencies as well as to changes in the reward-value of the outcome. When networks involved in reward processing and contingency learning are maladaptive, this fundamental ability can be lost, with detrimental consequences for decision-making. Impaired decision-making is a core feature in a number of psychiatric disorders, ranging from depression to schizophrenia. The argument can be developed, therefore, that seemingly disparate symptoms across psychiatric disorders can be explained by dysfunction within common decision-making circuitry. From this perspective, gaining a better understanding of the neural processes involved in goal-directed action, will allow a comparison of deficits observed across traditional diagnostic boundaries within a unified theoretical framework. This review describes the key processes and neural circuits involved in goal-directed decision-making using evidence from animal studies and human neuroimaging. Select studies are discussed to outline what we currently know about causal judgments regarding actions and their consequences, action-related reward evaluation, and, most importantly, how these processes are integrated in goal-directed learning and performance. Finally, we look at how adaptive decision-making is impaired across a range of psychiatric disorders and how deepening our understanding of this circuitry may offer insights into phenotypes and more targeted interventions. PMID:24904322

  13. Better sales networks.

    PubMed

    Ustüner, Tuba; Godes, David

    2006-01-01

    Anyone in sales will tell you that social networks are critical. The more contacts you have, the more leads you'll generate, and, ultimately, the more sales you'll make. But that's a vast oversimplification. Different configurations of networks produce different results, and the salesperson who develops a nuanced understanding of social networks will outshine competitors. The salesperson's job changes over the course of the selling process. Different abilities are required in each stage of the sale: identifying prospects, gaining buy-in from potential customers, creating solutions, and closing the deal. Success in the first stage, for instance, depends on the salesperson acquiring precise and timely information about opportunities from contacts in the marketplace. Closing the deal requires the salesperson to mobilize contacts from prior sales to act as references. Managers often view sales networks only in terms of direct contacts. But someone who knows lots of people doesn't necessarily have an effective network because networks often pay off most handsomely through indirect contacts. Moreover, the density of the connections in a network is important. Do a salesperson's contacts know all the same people, or are their associates widely dispersed? Sparse networks are better, for example, at generating unique information. Managers can use three levers--sales force structure, compensation, and skills development--to encourage salespeople to adopt a network-based view and make the best possible use of social webs. For example, the sales force can be restructured to decouple lead generation from other tasks because some people are very good at building diverse ties but not so good at maintaining other kinds of networks. Companies that take steps of this kind to help their sales teams build better networks will reap tremendous advantages.

  14. Better sales networks.

    PubMed

    Ustüner, Tuba; Godes, David

    2006-01-01

    Anyone in sales will tell you that social networks are critical. The more contacts you have, the more leads you'll generate, and, ultimately, the more sales you'll make. But that's a vast oversimplification. Different configurations of networks produce different results, and the salesperson who develops a nuanced understanding of social networks will outshine competitors. The salesperson's job changes over the course of the selling process. Different abilities are required in each stage of the sale: identifying prospects, gaining buy-in from potential customers, creating solutions, and closing the deal. Success in the first stage, for instance, depends on the salesperson acquiring precise and timely information about opportunities from contacts in the marketplace. Closing the deal requires the salesperson to mobilize contacts from prior sales to act as references. Managers often view sales networks only in terms of direct contacts. But someone who knows lots of people doesn't necessarily have an effective network because networks often pay off most handsomely through indirect contacts. Moreover, the density of the connections in a network is important. Do a salesperson's contacts know all the same people, or are their associates widely dispersed? Sparse networks are better, for example, at generating unique information. Managers can use three levers--sales force structure, compensation, and skills development--to encourage salespeople to adopt a network-based view and make the best possible use of social webs. For example, the sales force can be restructured to decouple lead generation from other tasks because some people are very good at building diverse ties but not so good at maintaining other kinds of networks. Companies that take steps of this kind to help their sales teams build better networks will reap tremendous advantages. PMID:16846193

  15. Fine-Grained Analysis of Motionese: Eye Gaze, Object Exchanges, and Action Units in Infant-versus Adult-Directed Action

    ERIC Educational Resources Information Center

    Brand, Rebecca J.; Shallcross, Wendy L.; Sabatos, Maura G.; Massie, Kara Phaedra

    2007-01-01

    Mothers modify their actions when demonstrating objects to infants versus adults. Such modifications have been called infant-directed action (IDA) or "motionese" (Brand, Baldwin, & Ashburn, 2002). We investigated the IDA features of interactiveness and simplification by quantifying eye gaze, object exchanges, and action units enacted between…

  16. Dissociable effects of salience on attention and goal-directed action.

    PubMed

    Moher, Jeff; Anderson, Brian A; Song, Joo-Hyun

    2015-08-01

    Everyday behavior frequently involves encounters with multiple objects that compete for selection. For example, driving a car requires constant shifts of attention between oncoming traffic, rearview mirrors, and traffic signs and signals, among other objects. Behavioral goals often drive this selection process [1, 2]; however, they are not the sole determinant of selection. Physically salient objects, such as flashing, brightly colored hazard signs, or objects that are salient by virtue of learned associations with reward, such as pictures of food on a billboard, often capture attention regardless of the individual's goals [3-6]. It is typically thought that strongly salient distractor objects capture more attention and are more disruptive than weakly salient distractors [7, 8]. Counterintuitively, though, we found that this is true for perception, but not for goal-directed action. In a visually guided reaching task [9-11], we required participants to reach to a shape-defined target while trying to ignore salient distractors. We observed that strongly salient distractors produced less disruption in goal-directed action than weakly salient distractors. Thus, a strongly salient distractor triggers suppression during goal-directed action, resulting in enhanced efficiency and accuracy of target selection relative to when weakly salient distractors are present. In contrast, in a task requiring no goal-directed action, we found greater attentional interference from strongly salient distractors. Thus, while highly salient stimuli interfere strongly with perceptual processing, increased physical salience or associated value attenuates action-related interference.

  17. Responses to the advanced notice of proposed rulemaking EPA published on June 6, 1996 regarding changes to the EPA allowance auctions and elimination of the direct sale

    SciTech Connect

    Critchfield, L.R.

    1997-12-31

    On June 6, 1996, EPA`s Acid Rain Program published an advance notice of proposed rulemaking (ANPRM) in the Federal Register seeking comment on: (1) whether to change the design of the annual sulfur dioxide (SO{sub 2}) allowance auctions; (2) whether to change the timing of the allowance auctions; (3) whether to change the requirement that the minimum price of offered allowances must be in whole dollars, and (4) whether EPA should propose the ability to submit allowance transfers electronically. EPA also published on that day a proposed and direct final rule on whether to eliminate the direct sale. This paper documents the issues addressed in the ANPRM, the comments EPA received, and EPA`s responses to those comments. EPA received comments from 14 separate commenters.

  18. Direct detection of a single evoked action potential with MRS in Lumbricus terrestris.

    PubMed

    Poplawsky, Alexander J; Dingledine, Raymond; Hu, Xiaoping P

    2012-01-01

    Functional MRI (fMRI) measures neural activity indirectly by detecting the signal change associated with the hemodynamic response following brain activation. In order to alleviate the temporal and spatial specificity problems associated with fMRI, a number of attempts have been made to detect neural magnetic fields (NMFs) with MRI directly, but have thus far provided conflicting results. In this study, we used MR to detect axonal NMFs in the median giant fiber of the earthworm, Lumbricus terrestris, by examining the free induction decay (FID) with a sampling interval of 0.32 ms. The earthworm nerve cords were isolated from the vasculature and stimulated at the threshold of action potential generation. FIDs were acquired shortly after the stimulation, and simultaneous field potential recordings identified the presence or absence of single evoked action potentials. FIDs acquired when the stimulus did not evoke an action potential were summed as background. The phase of the background-subtracted FID exhibited a systematic change, with a peak phase difference of (-1.2 ± 0.3) × 10(-5) radians occurring at a time corresponding to the timing of the action potential. In addition, we calculated the possible changes in the FID magnitude and phase caused by a simulated action potential using a volume conductor model. The measured phase difference matched the theoretical prediction well in both amplitude and temporal characteristics. This study provides the first evidence for the direct detection of a magnetic field from an evoked action potential using MR. PMID:21728204

  19. John porter lecture: waves of protest--direct action, deliberation, and diffusion.

    PubMed

    Wood, Lesley

    2015-02-01

    The book Direct Action, Deliberation and Diffusion: Collective Action After the WTO Protests in Seattle argues that the process of diffusion is dependent on social processes in the receiving context. The most important in social movements is an egalitarian and reflexive deliberation among diverse actors. The book traces the direct action tactics associated with the Seattle protests against the World Trade Organization in 1999 and how these spread to activists in Toronto and New York City. It shows how the structure of the political field, racial and class inequalities, identity boundaries, and organizational and conversational dynamics limited deliberation among activists, and thus limited the diffusion of the Seattle tactics. By constraining the spread of the Seattle tactics, this slowed the global justice movement's wave of protest. In this paper, I explore the application of and implications of this model of protest tactic diffusion to the recent Idle No More mobilizations. PMID:25737463

  20. Blazing the Trail: A New Direction in Youth Development & Leadership--Youth Call-to-Action

    ERIC Educational Resources Information Center

    Katzel, A.; LaVant, A.; Richards, C.

    2010-01-01

    In August 2007, more than 200 youth and adults came together in Washington D.C. to discuss what action steps should be done to ensure that young people are best prepared to move successfully from youth to adulthood. A major purpose of the event, called "Blazing the Trail: A New Direction in Youth Development & Leadership," was to talk about…

  1. 30 CFR 253.61 - When is a guarantor subject to direct action for claims?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Claims for Oil-Spill Removal Costs and Damages § 253.61 When is a guarantor subject to direct action for...., oil-spill discharge or substantial threat of the discharge of oil) that is subject to claims...

  2. Should I stay or should I go? Conceptual underpinnings of goal-directed actions

    PubMed Central

    Mirabella, Giovanni

    2014-01-01

    All actions, even the simplest like moving an arm to grasp a pen, are associated with energy costs. Thus all mobile organisms possess the ability to evaluate resources and select those behaviors that are most likely to lead to the greatest accrual of valuable items (reward) in the near or, especially in the case of humans, distant future. The evaluation process is performed at all possible stages of the series of decisions that lead to the building of a goal-directed action or to its suppression. This is because all animals have a limited amount of energy and resources; to survive and be able to reproduce they have to minimize the costs and maximize the outcomes of their actions. These computations are at the root of behavioral flexibility. Two executive functions play a major role in generating flexible behaviors: (i) the ability to predict future outcomes of goal-directed actions; and (ii) the ability to cancel them when they are unlikely to accomplish valuable results. These two processes operate continuously during the entire course of a movement: during its genesis, its planning and even its execution, so that the motor output can be modulated or suppressed at any time before its execution. In this review, functional interactions of the extended neural network subserving generation and inhibition of goal-directed movements will be outlined, leading to the intriguing hypothesis that the performance of actions and their suppression are not specified by independent sets of brain regions. Rather, it will be proposed that acting and stopping are functions emerging from specific interactions between largely overlapping brain regions, whose activity is intimately linked (directly or indirectly) to the evaluations of pros and cons of an action. Such mechanism would allow the brain to perform as a highly efficient and flexible system, as different functions could be computed exploiting the same components operating in different configurations. PMID:25404898

  3. Huntsville Arsenal for Sale

    NASA Technical Reports Server (NTRS)

    1940-01-01

    In the years following World War II, the Army directed that the Huntsville, Alabama Arsenal be advertised for sale. The decision was reversed because the Army found it needed this land for the new missile work that would occur at Redstone Arsenal.

  4. 78 FR 7809 - Notice of Realty Action: Proposed (Non-Competitive) Direct Sale of Public Land in Campbell County...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... address, 307-684-1178, or email to doliveri@blm.gov . Persons who use a telecommunications device for the... Buffalo Resource Management Plan (RMP) approved on October 4, 1985. The parcel is identified for disposal... delivered within 45 days of the initial date of publication of this Notice. Electronic mail (email)...

  5. 75 FR 21037 - Notice of Realty Action: Proposed Non-Competitive (Direct) Sales of Public Lands, Boulder County, CO

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-22

    ... appraised fair market value (FMV) to resolve historical inadvertent, unauthorized occupancy of the parcels... Resource Management Plan, dated September 16, 1986, and have been reviewed with State and local officials... lands and potential effects of local regulations and policies on potential future land uses....

  6. 78 FR 7810 - Notice of Realty Action: Proposed (Non-Competitive) Direct Sale of Public Lands in Sheridan...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... will be segregated from appropriation under the public land laws, including the mining laws, except the..., publication in the Federal Register of a termination of the segregation, or February 4, 2015, unless...

  7. 77 FR 31034 - Notice of Realty Action: Non-Competitive Direct Sale of Reversionary Interest Recreation and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... west of Channel 10 Drive in Las Vegas, Nevada. The following described land was patented to The Roman... is not suitable for management by another Federal department or agency. The Roman Catholic Bishop of... simple title for The Roman Catholic Bishop of Las Vegas to then sell the parcel without conditions...

  8. 75 FR 38547 - Notice of Realty Action: Non-Competitive (Direct) Sale of Public Lands and Termination of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-02

    ... continued use as a construction and demolition (C&D) landfill. In addition, this notice will terminate the.... The Madison County Commissioners propose to continue using the property as a C&D landfill to meet..., for a municipal solid waste landfill. In 1994, the County stopped using the site as a...

  9. 78 FR 75578 - Notice of Realty Action; Notice of Segregation and Proposed (Non-Competitive) Direct Sale of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-12

    ... land totaling 60 acres adjacent to the Jim Bridger Power Plant landfill and located approximately 30..., Rock Springs, WY 82901-3447. Comments may also be emailed to BLM_WY_PacifiCorp_Landfill_Expansion@blm...Corp to expand the adjacent landfill. PacifiCorp's private lands surround three sides of the...

  10. 78 FR 32688 - Notice of Realty Action, Segregation Terminated, Direct Sale of Public Land in San Bernardino...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... February 10, 2010 (75 FR 6702). This previous segregation will terminate on May 31, 2013 and be replaced... cable issued to U.S. Sprint Communications under serial number CACA 20105. 3. Subject to a ROW for...

  11. 78 FR 11899 - Notice of Realty Action: Direct Sale of Public Land in San Mateo County, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-20

    ... potential report which concluded that, with the exception of oil and gas resources in parcel one, there are... lessees to prospect for, mine, and remove the minerals under applicable law and such regulations as...

  12. The feeling of action tendencies: on the emotional regulation of goal-directed behavior.

    PubMed

    Lowe, Robert; Ziemke, Tom

    2011-01-01

    In this article, we review the nature of the functional and causal relationship between neurophysiologically/psychologically generated states of emotional feeling and action tendencies and extrapolate a novel perspective. Emotion theory, over the past century and beyond, has tended to regard feeling and action tendency as independent phenomena: attempts to outline the functional and causal relationship that exists between them have been framed therein. Classically, such relationships have been viewed as unidirectional, but an argument for bidirectionality rooted in a dynamic systems perspective has gained strength in recent years whereby the feeling-action tendency relationship is viewed as a composite whole. On the basis of our review of somatic-visceral theories of feelings, we argue that feelings are grounded upon neural-dynamic representations (elevated and stable activation patterns) of action tendency. Such representations amount to predictions updated by cognitive and bodily feedback. Specifically, we view emotional feelings as minimalist predictions of the action tendency (what the agent is physiologically and cognitively primed to do) in a given situation. The essence of this point is captured by our exposition of action tendency prediction-feedback loops which we consider, above all, in the context of emotion regulation, and in particular, of emotional regulation of goal-directed behavior. The perspective outlined may be of use to emotion theorists, computational modelers, and roboticists.

  13. The Feeling of Action Tendencies: On the Emotional Regulation of Goal-Directed Behavior

    PubMed Central

    Lowe, Robert; Ziemke, Tom

    2011-01-01

    In this article, we review the nature of the functional and causal relationship between neurophysiologically/psychologically generated states of emotional feeling and action tendencies and extrapolate a novel perspective. Emotion theory, over the past century and beyond, has tended to regard feeling and action tendency as independent phenomena: attempts to outline the functional and causal relationship that exists between them have been framed therein. Classically, such relationships have been viewed as unidirectional, but an argument for bidirectionality rooted in a dynamic systems perspective has gained strength in recent years whereby the feeling–action tendency relationship is viewed as a composite whole. On the basis of our review of somatic–visceral theories of feelings, we argue that feelings are grounded upon neural-dynamic representations (elevated and stable activation patterns) of action tendency. Such representations amount to predictions updated by cognitive and bodily feedback. Specifically, we view emotional feelings as minimalist predictions of the action tendency (what the agent is physiologically and cognitively primed to do) in a given situation. The essence of this point is captured by our exposition of action tendency prediction–feedback loops which we consider, above all, in the context of emotion regulation, and in particular, of emotional regulation of goal-directed behavior. The perspective outlined may be of use to emotion theorists, computational modelers, and roboticists. PMID:22207854

  14. Na+/H+ exchanger-1 inhibitors decrease myocardial superoxide production via direct mitochondrial action.

    PubMed

    Garciarena, Carolina D; Caldiz, Claudia I; Correa, María V; Schinella, Guillermo R; Mosca, Susana M; Chiappe de Cingolani, Gladys E; Cingolani, Horacio E; Ennis, Irene L

    2008-12-01

    The possibility of a direct mitochondrial action of Na(+)/H(+) exchanger-1 (NHE-1) inhibitors decreasing reactive oxygen species (ROS) production was assessed in cat myocardium. Angiotensin II and endothelin-1 induced an NADPH oxidase (NOX)-dependent increase in anion superoxide (O(2)(-)) production detected by chemiluminescence. Three different NHE-1 inhibitors [cariporide, BIIB-723, and EMD-87580] with no ROS scavenger activity prevented this increase. The mitochondria appeared to be the source of the NOX-dependent ROS released by the "ROS-induced ROS release mechanism" that was blunted by the mitochondrial ATP-sensitive potassium channel blockers 5-hydroxydecanoate and glibenclamide, inhibition of complex I of the electron transport chain with rotenone, and inhibition of the permeability transition pore (MPTP) by cyclosporin A. Cariporide also prevented O(2)(-) production induced by the opening of mK(ATP) with diazoxide. Ca(2+)-induced swelling was evaluated in isolated mitochondria as an indicator of MPTP formation. Cariporide decreased mitochondrial swelling to the same extent as cyclosporin A and bongkrekic acid, confirming its direct mitochondrial action. Increased O(2)(-) production, as expected, stimulated ERK1/2 and p90 ribosomal S6 kinase phosphorylation. This was also prevented by cariporide, giving additional support to the existence of a direct mitochondrial action of NHE-1 inhibitors in preventing ROS release. In conclusion, we report a mitochondrial action of NHE-1 inhibitors that should lead us to revisit or reinterpret previous landmark observations about their beneficial effect in several cardiac diseases, such as ischemia-reperfusion injury and cardiac hypertrophy and failure. Further studies are needed to clarify the precise mechanism and site of action of these drugs in blunting MPTP formation and ROS release. PMID:18801963

  15. Cortical kinematic processing of executed and observed goal-directed hand actions.

    PubMed

    Marty, Brice; Bourguignon, Mathieu; Jousmäki, Veikko; Wens, Vincent; Op de Beeck, Marc; Van Bogaert, Patrick; Goldman, Serge; Hari, Riitta; De Tiège, Xavier

    2015-10-01

    Motor information conveyed by viewing the kinematics of an agent's action helps to predict how the action will unfold. Still, how observed movement kinematics is processed in the brain remains to be clarified. Here, we used magnetoencephalography (MEG) to determine at which frequency and where in the brain, the neural activity is coupled with the kinematics of executed and observed motor actions. Whole-scalp MEG signals were recorded from 11 right-handed healthy adults while they were executing (Self) or observing (Other) similar goal-directed hand actions performed by an actor placed in front of them. Actions consisted of pinching with the right hand green foam-made pieces mixed in a heap with pieces of other colors placed on a table, and put them in a plastic pot on the right side of the heap. Subjects' and actor's forefinger movements were monitored with an accelerometer. The coherence between movement acceleration and MEG signals was computed at the sensor level. Then, cortical sources coherent with movement acceleration were identified with Dynamic Imaging of Coherent Sources. Statistically significant sensor-level coherence peaked at the movement frequency (F0) and its first harmonic (F1) in both movement conditions. Apart from visual cortices, statistically significant local maxima of coherence were observed in the right posterior superior temporal gyrus (F0), bilateral superior parietal lobule (F0 or F1) and primary sensorimotor cortex (F0 or F1) in both movement conditions. These results suggest that observing others' actions engages the viewer's brain in a similar kinematic-related manner as during own action execution. These findings bring new insights into how human brain activity covaries with essential features of observed movements of others. PMID:26123380

  16. Cortical kinematic processing of executed and observed goal-directed hand actions.

    PubMed

    Marty, Brice; Bourguignon, Mathieu; Jousmäki, Veikko; Wens, Vincent; Op de Beeck, Marc; Van Bogaert, Patrick; Goldman, Serge; Hari, Riitta; De Tiège, Xavier

    2015-10-01

    Motor information conveyed by viewing the kinematics of an agent's action helps to predict how the action will unfold. Still, how observed movement kinematics is processed in the brain remains to be clarified. Here, we used magnetoencephalography (MEG) to determine at which frequency and where in the brain, the neural activity is coupled with the kinematics of executed and observed motor actions. Whole-scalp MEG signals were recorded from 11 right-handed healthy adults while they were executing (Self) or observing (Other) similar goal-directed hand actions performed by an actor placed in front of them. Actions consisted of pinching with the right hand green foam-made pieces mixed in a heap with pieces of other colors placed on a table, and put them in a plastic pot on the right side of the heap. Subjects' and actor's forefinger movements were monitored with an accelerometer. The coherence between movement acceleration and MEG signals was computed at the sensor level. Then, cortical sources coherent with movement acceleration were identified with Dynamic Imaging of Coherent Sources. Statistically significant sensor-level coherence peaked at the movement frequency (F0) and its first harmonic (F1) in both movement conditions. Apart from visual cortices, statistically significant local maxima of coherence were observed in the right posterior superior temporal gyrus (F0), bilateral superior parietal lobule (F0 or F1) and primary sensorimotor cortex (F0 or F1) in both movement conditions. These results suggest that observing others' actions engages the viewer's brain in a similar kinematic-related manner as during own action execution. These findings bring new insights into how human brain activity covaries with essential features of observed movements of others.

  17. How to Build an Intentional Android: Infants' Imitation of a Robot's Goal-Directed Actions

    ERIC Educational Resources Information Center

    Itakura, Shoji; Ishida, Hiraku; Kanda, Takayuki; Shimada, Yohko; Ishiguro, Hiroshi; Lee, Kang

    2008-01-01

    This study examined whether young children are able to imitate a robot's goal-directed actions. Children (24-35 months old) viewed videos showing a robot attempting to manipulate an object (e.g., putting beads inside a cup) but failing to achieve its goal (e.g., beads fell outside the cup). In 1 video, the robot made eye contact with a human…

  18. Observing Grasping Actions Directed to Emotion-Laden Objects: Effects upon Corticospinal Excitability

    PubMed Central

    Nogueira-Campos, Anaelli A.; Saunier, Ghislain; Della-Maggiore, Valeria; De Oliveira, Laura A. S.; Rodrigues, Erika C.; Vargas, Claudia D.

    2016-01-01

    The motor system is recruited whenever one executes an action as well as when one observes the same action being executed by others. Although it is well established that emotion modulates the motor system, the effect of observing other individuals acting in an emotional context is particularly elusive. The main aim of this study was to investigate the effect induced by the observation of grasping directed to emotion-laden objects upon corticospinal excitability (CSE). Participants classified video-clips depicting the right-hand of an actor grasping emotion-laden objects. Twenty video-clips differing in terms of valence but balanced in arousal level were selected. Motor evoked potentials (MEPs) were then recorded from the first dorsal interosseous using transcranial magnetic stimulation (TMS) while the participants observed the selected emotional video-clips. During the video-clip presentation, TMS pulses were randomly applied at one of two different time points of grasping: (1) maximum grip aperture, and (2) object contact time. CSE was higher during the observation of grasping directed to unpleasant objects compared to pleasant ones. These results indicate that when someone observes an action of grasping directed to emotion-laden objects, the effect of the object valence promotes a specific modulation over the motor system. PMID:27625602

  19. Observing Grasping Actions Directed to Emotion-Laden Objects: Effects upon Corticospinal Excitability.

    PubMed

    Nogueira-Campos, Anaelli A; Saunier, Ghislain; Della-Maggiore, Valeria; De Oliveira, Laura A S; Rodrigues, Erika C; Vargas, Claudia D

    2016-01-01

    The motor system is recruited whenever one executes an action as well as when one observes the same action being executed by others. Although it is well established that emotion modulates the motor system, the effect of observing other individuals acting in an emotional context is particularly elusive. The main aim of this study was to investigate the effect induced by the observation of grasping directed to emotion-laden objects upon corticospinal excitability (CSE). Participants classified video-clips depicting the right-hand of an actor grasping emotion-laden objects. Twenty video-clips differing in terms of valence but balanced in arousal level were selected. Motor evoked potentials (MEPs) were then recorded from the first dorsal interosseous using transcranial magnetic stimulation (TMS) while the participants observed the selected emotional video-clips. During the video-clip presentation, TMS pulses were randomly applied at one of two different time points of grasping: (1) maximum grip aperture, and (2) object contact time. CSE was higher during the observation of grasping directed to unpleasant objects compared to pleasant ones. These results indicate that when someone observes an action of grasping directed to emotion-laden objects, the effect of the object valence promotes a specific modulation over the motor system. PMID:27625602

  20. Visual control of braking in goal-directed action and sport.

    PubMed

    Bardy, B G; Warren, W H

    1997-12-01

    Reaching a moving object, avoiding an obstacle, or controlling a rotation are common requirements of experts in sport and goal-directed action. Since the original analysis of optic flow, a large number of studies have addressed the problem of perception and control of braking. In this paper, the perception-action strategies described for deceleration control are reviewed; driving, docking, landing, somersaulting, running and reaching are analysed. The role played by 'tau dot', the first temporal derivative of tau, is shown to be critical. However, the so-called constant tau-dot strategy proposed to explain how we regulate our deceleration in such circumstances is critically examined and rejected. New directions in the problem of braking control are proposed that emphasize: (1) the advantage of tau-dot over other kinematic variables; (2) the task specificity of tau-dot; (3) the need to consider tau-dot as a control variable; and (4) the role played by the controller dynamics in the perception-action loop. Several directions for future research are suggested. PMID:9486438

  1. Observing Grasping Actions Directed to Emotion-Laden Objects: Effects upon Corticospinal Excitability

    PubMed Central

    Nogueira-Campos, Anaelli A.; Saunier, Ghislain; Della-Maggiore, Valeria; De Oliveira, Laura A. S.; Rodrigues, Erika C.; Vargas, Claudia D.

    2016-01-01

    The motor system is recruited whenever one executes an action as well as when one observes the same action being executed by others. Although it is well established that emotion modulates the motor system, the effect of observing other individuals acting in an emotional context is particularly elusive. The main aim of this study was to investigate the effect induced by the observation of grasping directed to emotion-laden objects upon corticospinal excitability (CSE). Participants classified video-clips depicting the right-hand of an actor grasping emotion-laden objects. Twenty video-clips differing in terms of valence but balanced in arousal level were selected. Motor evoked potentials (MEPs) were then recorded from the first dorsal interosseous using transcranial magnetic stimulation (TMS) while the participants observed the selected emotional video-clips. During the video-clip presentation, TMS pulses were randomly applied at one of two different time points of grasping: (1) maximum grip aperture, and (2) object contact time. CSE was higher during the observation of grasping directed to unpleasant objects compared to pleasant ones. These results indicate that when someone observes an action of grasping directed to emotion-laden objects, the effect of the object valence promotes a specific modulation over the motor system.

  2. Anticlockwise or clockwise? A dynamic Perception-Action-Laterality model for directionality bias in visuospatial functioning.

    PubMed

    Karim, A K M Rezaul; Proulx, Michael J; Likova, Lora T

    2016-09-01

    Orientation bias and directionality bias are two fundamental functional characteristics of the visual system. Reviewing the relevant literature in visual psychophysics and visual neuroscience we propose here a three-stage model of directionality bias in visuospatial functioning. We call this model the 'Perception-Action-Laterality' (PAL) hypothesis. We analyzed the research findings for a wide range of visuospatial tasks, showing that there are two major directionality trends in perceptual preference: clockwise versus anticlockwise. It appears these preferences are combinatorial, such that a majority of people fall in the first category demonstrating a preference for stimuli/objects arranged from left-to-right rather than from right-to-left, while people in the second category show an opposite trend. These perceptual biases can guide sensorimotor integration and action, creating two corresponding turner groups in the population. In support of PAL, we propose another model explaining the origins of the biases - how the neurogenetic factors and the cultural factors interact in a biased competition framework to determine the direction and extent of biases. This dynamic model can explain not only the two major categories of biases in terms of direction and strength, but also the unbiased, unreliably biased or mildly biased cases in visuosptial functioning. PMID:27350096

  3. 40 CFR 73.73 - Delegation of auctions and sales and termination of auctions and sales.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 17 2013-07-01 2013-07-01 false Delegation of auctions and sales and termination of auctions and sales. 73.73 Section 73.73 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Auctions, Direct Sales,...

  4. 40 CFR 73.73 - Delegation of auctions and sales and termination of auctions and sales.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Delegation of auctions and sales and termination of auctions and sales. 73.73 Section 73.73 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Auctions, Direct Sales,...

  5. 40 CFR 73.73 - Delegation of auctions and sales and termination of auctions and sales.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 16 2011-07-01 2011-07-01 false Delegation of auctions and sales and termination of auctions and sales. 73.73 Section 73.73 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Auctions, Direct Sales,...

  6. 40 CFR 73.73 - Delegation of auctions and sales and termination of auctions and sales.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 17 2014-07-01 2014-07-01 false Delegation of auctions and sales and termination of auctions and sales. 73.73 Section 73.73 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Auctions, Direct Sales,...

  7. 40 CFR 73.73 - Delegation of auctions and sales and termination of auctions and sales.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 17 2012-07-01 2012-07-01 false Delegation of auctions and sales and termination of auctions and sales. 73.73 Section 73.73 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Auctions, Direct Sales,...

  8. Action!

    ERIC Educational Resources Information Center

    Senese, Joseph

    1998-01-01

    A small group of teachers at one Illinois high school is helping to effect and promote change. Through the Action Research Laboratory (ARL), teams of teachers conduct collaborative action research to improve classroom practices. Data from the first two years of the ARL indicate that teachers are eager to participate in, and have thrived in, their…

  9. 77 FR 51697 - Telemarketing Sales Rule Fees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-27

    ... CFR Part 310 RIN 3084-AA98 Telemarketing Sales Rule Fees AGENCY: Federal Trade Commission. ACTION... Telemarketing Sales Rule (``TSR'') by updating the fees charged to entities accessing the National Do Not Call Registry (the ``Registry'') as required by the Do-Not-Call Registry Fee Extension Act of 2007....

  10. 76 FR 53636 - Telemarketing Sales Rule Fees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-29

    ... CFR Part 310 RIN 3084-AA98 Telemarketing Sales Rule Fees AGENCY: Federal Trade Commission. ACTION... Telemarketing Sales Rule (``TSR'') by updating the fees ] charged to entities accessing the National Do Not Call Registry (the Registry as required by the Do-Not-Call Registry Fee Extension Act of 2007. DATES:...

  11. 78 FR 53642 - Telemarketing Sales Rule Fees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-30

    ... 3084-AA98 16 CFR Part 310 Telemarketing Sales Rule Fees AGENCY: Federal Trade Commission. ACTION: Final... Telemarketing Sales Rule (``TSR'') by updating the fees charged to entities accessing the National Do Not Call Registry (the ``Registry'') as required by the Do-Not-Call Registry Fee Extension Act of 2007....

  12. 76 FR 58716 - Telemarketing Sales Rule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-22

    ... From the Federal Register Online via the Government Publishing Office FEDERAL TRADE COMMISSION 16 CFR Part 310 Telemarketing Sales Rule AGENCY: Federal Trade Commission. ACTION: Correcting amendments. SUMMARY: The Federal Trade Commission published a final amended Telemarketing Sales Rule in the...

  13. 75 FR 51934 - Telemarketing Sales Rule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-24

    ... Protection, Federal Trade Commission, Washington, DC 20580 (202-326-3224). SUPPLEMENTARY INFORMATION: In FR... CFR Part 310 Telemarketing Sales Rule AGENCY: Federal Trade Commission. ACTION: Final rule; correction... amendments to the Telemarketing Sales Rule that address the telemarketing of debt relief services....

  14. Direct and indirect cardiovascular actions of cathinone and MDMA in the anaesthetized rat.

    PubMed

    Alsufyani, Hadeel A; Docherty, James R

    2015-07-01

    The stimulants cathinone (from Khat leaves) and methylenedioxymeth-amphetamine (MDMA) produce adrenoceptor mediated tachycardia and vasopressor actions that may be the result of direct receptor stimulation, actions on the noradrenaline transporter, and/or displacement of noradrenaline from nerve terminals. Effects of cathinone or MDMA were compared with those of the indirect sympathomimetic tyramine. Male Wistar rats were anaesthetized with pentobarbitone for blood pressure and heart rate recording. Some rats were sympathectomised by treatment with 6-hydroxydopamine. In the anaesthetised rat, cathinone, MDMA and tyramine (all 0.001-1 mg/kg) produced marked tachycardia, tyramine produced marked pressor responses and MDMA produced small pressor responses. The tachycardia to cathinone and MDMA was almost abolished by propranolol (1mg/kg). Pretreatment with cocaine (1mg/kg) did not significantly affect the tachycardia to cathinone or MDMA, but reduced the response to tyramine. However, in sympathectomised rats, the tachycardia to cathinone or MDMA was markedly attenuated, but the tachycardia to tyramine was only partially reduced. Blood pressure effects of tyramine and MDMA were also markedly attenuated by sympathectomy. The results demonstrate firstly that cocaine may not be the most suitable agent for assessing direct versus indirect agonism in cardiovascular studies. Secondly, the use of chemical sympathectomy achieved the desired goal of demonstrating that cardiac β-adrenoceptor mediated actions of cathinone and MDMA are probably largely indirect.

  15. Modeling Geometric-Temporal Context With Directional Pyramid Co-Occurrence for Action Recognition.

    PubMed

    Yuan, Chunfeng; Li, Xi; Hu, Weiming; Ling, Haibin; Maybank, Stephen J

    2014-02-01

    In this paper, we present a new geometric-temporal representation for visual action recognition based on local spatio-temporal features. First, we propose a modified covariance descriptor under the log-Euclidean Riemannian metric to represent the spatio-temporal cuboids detected in the video sequences. Compared with previously proposed covariance descriptors, our descriptor can be measured and clustered in Euclidian space. Second, to capture the geometric-temporal contextual information, we construct a directional pyramid co-occurrence matrix (DPCM) to describe the spatio-temporal distribution of the vector-quantized local feature descriptors extracted from a video. DPCM characterizes the co-occurrence statistics of local features as well as the spatio-temporal positional relationships among the concurrent features. These statistics provide strong descriptive power for action recognition. To use DPCM for action recognition, we propose a directional pyramid co-occurrence matching kernel to measure the similarity of videos. The proposed method achieves the state-of-the-art performance and improves on the recognition performance of the bag-of-visual-words (BOVWs) models by a large margin on six public data sets. For example, on the KTH data set, it achieves 98.78% accuracy while the BOVW approach only achieves 88.06%. On both Weizmann and UCF CIL data sets, the highest possible accuracy of 100% is achieved. PMID:26270910

  16. The direct perception hypothesis: perceiving the intention of another’s action hinders its precise imitation

    PubMed Central

    Froese, Tom; Leavens, David A.

    2014-01-01

    We argue that imitation is a learning response to unintelligible actions, especially to social conventions. Various strands of evidence are converging on this conclusion, but further progress has been hampered by an outdated theory of perceptual experience. Comparative psychology continues to be premised on the doctrine that humans and non-human primates only perceive others’ physical “surface behavior,” while mental states are perceptually inaccessible. However, a growing consensus in social cognition research accepts the direct perception hypothesis: primarily we see what others aim to do; we do not infer it from their motions. Indeed, physical details are overlooked – unless the action is unintelligible. On this basis we hypothesize that apes’ propensity to copy the goal of an action, rather than its precise means, is largely dependent on its perceived intelligibility. Conversely, children copy means more often than adults and apes because, uniquely, much adult human behavior is completely unintelligible to unenculturated observers due to the pervasiveness of arbitrary social conventions, as exemplified by customs, rituals, and languages. We expect the propensity to imitate to be inversely correlated with the familiarity of cultural practices, as indexed by age and/or socio-cultural competence. The direct perception hypothesis thereby helps to parsimoniously explain the most important findings of imitation research, including children’s over-imitation and other species-typical and age-related variations. PMID:24600413

  17. The direct perception hypothesis: perceiving the intention of another's action hinders its precise imitation.

    PubMed

    Froese, Tom; Leavens, David A

    2014-01-01

    We argue that imitation is a learning response to unintelligible actions, especially to social conventions. Various strands of evidence are converging on this conclusion, but further progress has been hampered by an outdated theory of perceptual experience. Comparative psychology continues to be premised on the doctrine that humans and non-human primates only perceive others' physical "surface behavior," while mental states are perceptually inaccessible. However, a growing consensus in social cognition research accepts the direct perception hypothesis: primarily we see what others aim to do; we do not infer it from their motions. Indeed, physical details are overlooked - unless the action is unintelligible. On this basis we hypothesize that apes' propensity to copy the goal of an action, rather than its precise means, is largely dependent on its perceived intelligibility. Conversely, children copy means more often than adults and apes because, uniquely, much adult human behavior is completely unintelligible to unenculturated observers due to the pervasiveness of arbitrary social conventions, as exemplified by customs, rituals, and languages. We expect the propensity to imitate to be inversely correlated with the familiarity of cultural practices, as indexed by age and/or socio-cultural competence. The direct perception hypothesis thereby helps to parsimoniously explain the most important findings of imitation research, including children's over-imitation and other species-typical and age-related variations.

  18. The impact of direct-to-consumer advertised drugs on drug sales in the US and New Zealand.

    PubMed

    Norey, Edward; Simone, Tessa M; Mousa, Shaker A

    2008-01-01

    Direct-to-consumer advertising (DTCA) of drugs has been suggested to be a factor in the increased burden of healthcare spending within the US. This review article analyses the pharmaceutical spending differences between the US and New Zealand, two nations that allow DTCA. The pharmaceutical spending burden of New Zealand and the US was compared by assessing the impact of heavily advertised drugs and their position and rank in the pharmaceutical spending of their respective nation. The US spends far more money on pharmaceuticals than New Zealand. It may appear that heavily advertised drugs in the US have a potentially larger impact on what is being prescribed and paid for. It is also probable that the differences in healthcare systems in each nation (free market vs socialized medicine) can have an influence on pharmaceutical spending. The great amount of money being spent on pharmaceuticals per capita in the US is a more complex issue than can be solved solely by targeting DTCA. PMID:19231903

  19. Turning over renal osteodystrophy dogma: direct actions of FGF23 on osteoblast β-catenin pathway.

    PubMed

    Schiavi, Susan C; Moysés, Rosa M A

    2016-07-01

    Although recognized as a major complication of chronic kidney disease (CKD), the pathophysiology of the CKD-related mineral and bone disorder (CKD-MBD) is not completely understood. Recently, the inhibition of Wnt/β-catenin pathway in osteocytes by sclerostin has been shown to play a role in CKD-MBD. The study by Carrilo-Lopez et al. confirms this inhibition in an experimental model of CKD. Moreover, they describe direct actions of FGF23-Klotho on osteoblasts, increasing the expression of DKK1, another Wnt/β-catenin pathway inhibitor. PMID:27312441

  20. Anticipatory synergy adjustments: preparing a quick action in an unknown direction.

    PubMed

    Zhou, Tao; Wu, Yen-Hsun; Bartsch, Angelo; Cuadra, Cristian; Zatsiorsky, Vladimir M; Latash, Mark L

    2013-05-01

    We studied a mechanism of feed-forward control of a multi-finger action, namely anticipatory synergy adjustments (ASAs), prior to a quick force correction in response to a change in the gain of the visual feedback. Synergies were defined as co-varied across trials adjustments of commands to fingers that stabilized (decreased variance of) the total force. We hypothesized that ASAs would be highly sensitive to prior information about the timing of the action but not to information on its direction, i.e., on whether the gain would go up or down. The subjects produced accurate constant total force by pressing with four fingers on individual force sensors. The feedback signal could change from veridical (the sum of finger forces) to modified, with the middle finger force multiplied by 0.2 or by 1.8. The timing of the gain change and its direction could be known or unknown to the subject in advance. When the timing of the gain change was known, ASA was seen as a drop in the synergy index starting about 250-300 ms prior to the first visible correction of the total force. When the gain change timing was unknown, ASAs started much later, less than 100 ms prior to the total force correction. The magnitude of synergy index changes was significantly larger under the "time known" conditions. Information on the direction of the visual gain change had no effect on the ASA timing, while the ASA magnitude was somewhat larger when this information was not available to the subject. After the total force correction, the synergy index was significantly larger for the force signal computed using the modified gain values as compared to the synergy index value for the actual total force. We conclude that ASAs represent an important feed-forward motor control mechanism that allows preparing for a quick action even when the direction of the action is not known in advance. The results emphasize the subtle control of multi-finger synergies that are specific to the exact contributions of

  1. Anticipatory synergy adjustments: Preparing a quick action in an unknown direction

    PubMed Central

    Zhou, Tao; Wu, Yen-Hsun; Bartsch, Angelo; Cuadra, Cristian; Zatsiorsky, Vladimir M.; Latash, Mark L.

    2013-01-01

    We studied a mechanism of feed-forward control of a multi-finger action, namely anticipatory synergy adjustments (ASAs) prior to a quick force correction in response to a change in the gain of the visual feedback. Synergies were defined as co-varied across trials adjustments of commands to fingers that stabilized (decreased variance of) the total force. We hypothesized that ASAs would be highly sensitive to prior information about the timing of the action but not to information on its direction, i.e., on whether the gain would go up or down. The subjects produced accurate constant total force by pressing with four fingers on individual force sensors. The feedback signal could change from veridical (the sum of finger forces) to modified, with the middle finger force multiplied by 0.2 or by 1.8. The timing of the gain change and its direction could be known or unknown to the subject in advance. When the timing of the gain change was known, ASA was seen as a drop in the synergy index starting about 250–300 ms prior to the first visible correction of the total force. When the gain change timing was unknown, ASAs started much later, less than 100 ms prior to the total force correction. The magnitude of synergy index changes was significantly larger under the “time known” conditions. Information on the direction of the visual gain change had no effect on the ASA timing, while the ASA magnitude was somewhat larger when this information was not available to the subject. After the total force correction, the synergy index was significantly larger for the force signal computed using the modified gain values as compared to the synergy index value for the actual total force. We conclude that ASAs represent an important feed-forward motor control mechanism that allows preparing for a quick action even when the direction of the action is not known in advance. The results emphasize the subtle control of multi-finger synergies that are specific to the exact contributions of

  2. 77 FR 64096 - Information Collection; Advertised Timber for Sale

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-18

    ... Forest Service Information Collection; Advertised Timber for Sale AGENCY: Forest Service, USDA. ACTION... of the currently approved information collection 0596-0066 Advertised Timber for Sale. DATES... INFORMATION: Title: Advertised Timber for Sale. OMB Number: 0596-0066. Expiration Date of Approval: April...

  3. Direction of action potential propagation influences calcium increases in distal dendrites of the cricket giant interneurons.

    PubMed

    Ogawa, Hiroto; Baba, Yoshichika; Oka, Kotaro

    2002-10-01

    To understand the relationship between the propagation direction of action potentials and dendritic Ca(2+) elevation, simultaneous measurements of intracellular Ca(2+) concentration ([Ca(2+)](i)) and intradendritic membrane potential were performed in the wind-sensitive giant interneurons of the cricket. The dendritic Ca(2+) transients induced by synaptically-evoked action potentials had larger amplitudes than those induced by backpropagating spikes evoked by antidromic stimulation. The amplitude of the [Ca(2+)](i) changes induced by antidromic stimuli combined with subthreshold synaptic stimulation was not different from that of the Ca(2+) increases evoked by the backpropagating spikes alone. This result means that the synaptically activated Ca(2+) release from intracellular stores does not contribute to enhancement of Ca(2+) elevation induced by backpropagating spikes. On the other hand, the synaptically evoked action potentials were also increased at distal dendrites in which the Ca(2+) elevation was enhanced. When the dendritic and axonal spikes were simultaneously recorded, the delay between dendritic spike and ascending axonal spike depended upon which side of the cercal nerves was stimulated. Further, dual intracellular recording at different dendritic branches illustrated that the dendritic spike at the branch arborizing on the stimulated side preceded the spike recorded at the other side of the dendrite. These results suggest that the spike-initiation site shifts depending on the location of the activated postsynaptic site. It is proposed that the difference of spike propagation manner could change the action potential waveform at the distal dendrite, and could produce synaptic activity-dependent Ca(2+) dynamics in the giant interneurons.

  4. Action of methotrexate and tofacitinib on directly stimulated and bystander-activated lymphocytes.

    PubMed

    Piscianz, Elisa; Candilera, Vanessa; Valencic, Erica; Loganes, Claudia; Paron, Greta; De Iudicibus, Sara; Decorti, Giuliana; Tommasini, Alberto

    2016-07-01

    Chronic inflammation associated with autoimmune activation is characteristic of rheumatic diseases from childhood to adulthood. In recent decades, significant improvements in the treatment of these types of disease have been achieved using disease modifying anti-rheumatic drugs (DMARDs), such as methotrexate (MTX) and, more recently, using biologic inhibitors. The recent introduction of kinase inhibitors (for example, tofacitinib; Tofa) further increases the available ARDs. However, there are patients that do not respond to any treatment strategies, for whom combination therapies are proposed. The data regarding the combined action of different drugs is lacking and the knowledge of the mechanisms of ARDs and their actions upon pathogenic lymphocytes, which are hypothesized to sustain disease, is poor. An in vitro model of inflammation was developed in the current study, in which stimulated and unstimulated lymphocytes were cultured together, but tracked separately, to investigate the action of MTX and Tofa on the two populations. By analysing lymphocyte proliferation and activation, and cytokine secretion in the culture supernatants, it was established that, due to the presence of activated cells, unstimulated cells underwent a bystander activation that was modulated by the ARDs. Additionally, varying administration schedules were demonstrated to affect lymphocytes differently in vitro, either directly or via bystander activation. Furthermore, MTX and Tofa exerted different effects; while MTX showed an antiproliferative effect, Tofa marginally effected activation, although only a slight antiproliferative action, which could be potentiated by sequential treatment with MTX. Thus, it was hypothesized that these differences may be exploited in sequential therapeutic strategies, to maximize the anti‑rheumatic effect. These findings are notable and must be accounted for, as bystander‑activated cells in vivo could contribute to the spread of autoimmune activation

  5. The Neural Representation of Goal-Directed Actions and Outcomes in the Ventral Striatum's Olfactory Tubercle

    PubMed Central

    Gadziola, Marie A.

    2016-01-01

    The ventral striatum is critical for evaluating reward information and the initiation of goal-directed behaviors. The many cellular, afferent, and efferent similarities between the ventral striatum's nucleus accumbens and olfactory tubercle (OT) suggests the distributed involvement of neurons within the ventral striatopallidal complex in motivated behaviors. Although the nucleus accumbens has an established role in representing goal-directed actions and their outcomes, it is not known whether this function is localized within the nucleus accumbens or distributed also within the OT. Answering such a fundamental question will expand our understanding of the neural mechanisms underlying motivated behaviors. Here we address whether the OT encodes natural reinforcers and serves as a substrate for motivational information processing. In recordings from mice engaged in a novel water-motivated instrumental task, we report that OT neurons modulate their firing rate during initiation and progression of the instrumental licking behavior, with some activity being internally generated and preceding the first lick. We further found that as motivational drive decreases throughout a session, the activity of OT neurons is enhanced earlier relative to the behavioral action. Additionally, OT neurons discriminate the types and magnitudes of fluid reinforcers. Together, these data suggest that the processing of reward information and the orchestration of goal-directed behaviors is a global principle of the ventral striatum and have important implications for understanding the neural systems subserving addiction and mood disorders. SIGNIFICANCE STATEMENT Goal-directed behaviors are widespread among animals and underlie complex behaviors ranging from food intake, social behavior, and even pathological conditions, such as gambling and drug addiction. The ventral striatum is a neural system critical for evaluating reward information and the initiation of goal-directed behaviors. Here we

  6. Visual control of action directed toward two-dimensional objects relies on holistic processing of object shape.

    PubMed

    Freud, Erez; Ganel, Tzvi

    2015-10-01

    Visual perception relies on holistic processing of object shape. In contrast to perception, previous studies demonstrated that vision-for-action operates in a fundamentally different manner based on an analytical representation of objects. This notion was mainly supported by the absence of Garner interference for visually guided actions, compared to robust interference effects for perceptual estimations of the same objects. This study examines the nature of the representations that subserve visually guided actions toward two-dimensional (2D) stimuli. Based on recent results suggesting that actions directed toward 2D objects are mediated by different underlying processes compared to normal actions, we predicted that visually guided actions toward 2D stimuli would rely on perceptually driven holistic representations of object shape. To test this idea, we asked participants to grasp 2D rectangular objects presented on a computer monitor along their width while the values of the irrelevant dimension of length were either kept constant (baseline condition) or varied between trials (filtering condition). Worse performance in the filtering blocks is labeled Garner interference, which indicates holistic processing of object shape. Unlike in previous studies that used real objects, the results showed that grasping toward 2D objects produced a significant Garner interference effect, with more variable within-subject performance in the filtering compared to the baseline blocks. This finding suggests that visually guided actions directed toward 2D targets are mediated by different computations compared to visually guided actions directed toward real objects.

  7. The mechanisms of action of flavonoids in the brain: Direct versus indirect effects.

    PubMed

    Rendeiro, Catarina; Rhodes, Justin S; Spencer, Jeremy P E

    2015-10-01

    The projected increase in the incidence of dementia in the population highlights the urgent need for a more comprehensive understanding of how different aspects of lifestyle, in particular exercise and diet, may affect neural function and consequent cognitive performance throughout the life course. In this regard, flavonoids, found in a variety of fruits, vegetables and derived beverages, have been identified as a group of promising bioactive compounds capable of influencing different aspects of brain function, including cerebrovascular blood flow and synaptic plasticity, both resulting in improvements in learning and memory in mammalian species. However, the precise mechanisms by which flavonoids exert these actions are yet to be fully established, although accumulating data indicate an ability to interact with neuronal receptors and kinase signaling pathways which are key to neuronal activation and communication and synaptic strengthening. Alternatively or concurrently, there is also compelling evidence derived from human clinical studies suggesting that flavonoids can positively affect peripheral and cerebrovascular blood flow, which may be an indirect effective mechanism by which dietary flavonoids can impact on brain health and cognition. The current review examines the beneficial effects of flavonoids on both human and animal brain function and attempts to address and link direct and indirect actions of flavonoids and their derivatives within the central nervous system (CNS).

  8. Nutrient Sensor in the Brain Directs the Action of the Brain-Gut Axis in Drosophila.

    PubMed

    Dus, Monica; Lai, Jason Sih-Yu; Gunapala, Keith M; Min, Soohong; Tayler, Timothy D; Hergarden, Anne C; Geraud, Eliot; Joseph, Christina M; Suh, Greg S B

    2015-07-01

    Animals can detect and consume nutritive sugars without the influence of taste. However, the identity of the taste-independent nutrient sensor and the mechanism by which animals respond to the nutritional value of sugar are unclear. Here, we report that six neurosecretory cells in the Drosophila brain that produce Diuretic hormone 44 (Dh44), a homolog of the mammalian corticotropin-releasing hormone (CRH), were specifically activated by nutritive sugars. Flies in which the activity of these neurons or the expression of Dh44 was disrupted failed to select nutritive sugars. Manipulation of the function of Dh44 receptors had a similar effect. Notably, artificial activation of Dh44 receptor-1 neurons resulted in proboscis extensions and frequent episodes of excretion. Conversely, reduced Dh44 activity led to decreased excretion. Together, these actions facilitate ingestion and digestion of nutritive foods. We propose that the Dh44 system directs the detection and consumption of nutritive sugars through a positive feedback loop. PMID:26074004

  9. The androgen receptor has no direct antiresorptive actions in mouse osteoclasts.

    PubMed

    Sinnesael, Mieke; Jardi, Ferran; Deboel, Ludo; Laurent, Michaël R; Dubois, Vanessa; Zajac, Jeffrey D; Davey, Rachel A; Carmeliet, Geert; Claessens, Frank; Vanderschueren, Dirk

    2015-08-15

    Androgen deficiency or androgen receptor knockout (ARKO) causes high-turnover osteopenia, but the target cells for this effect remain unclear. To examine whether AR in osteoclasts directly suppresses bone resorption, we crossed AR-floxed with cathepsin K-Cre mice. Osteoclast-specific ARKO (ocl-ARKO) mice showed no changes neither in osteoclast surface nor in bone microarchitecture nor in the response to orchidectomy and androgen replacement, indicating that the AR in osteoclasts is not critical for bone maintenance. In line with the lack of a bone phenotype, the levels of AR were very low in osteoclast-enriched cultures derived from bone marrow (BM) and undetectable in osteoclasts generated from spleen precursors. Since tibiae of ubiquitous ARKO mice displayed increased osteoclast counts, the role of AR was further explored using cell cultures from these animals. Osteoclast generation and activity in vitro were similar between ARKO and wildtype control (WT) mice. In co-culture experiments, BM stromal cells (BMSCs) were essential for the suppressive action of AR on osteoclastogenesis and osteoclast activity. Stimulation with 1,25(OH)2 vitamin D3 increased Rankl and decreased Tnfsf11 (osteoprotegerin, Opg) gene expression in BMSCs more than in osteoblasts. This increase in the Rankl/Opg ratio following 1,25(OH)2D3 stimulation was lower, not higher, in ARKO mice. Runx2 expression in BMSCs was however higher in ARKO vs. WT, suggesting that ARKO mice may more readily commit osteoprogenitor cells to osteoblastogenesis. In conclusion, the AR does not seem to suppress bone resorption through direct actions in osteoclasts. BMSCs may however represent an alternative AR target in the BM milieu.

  10. DIRECT-ACTING, DNA-DAMAGING AS (III)-METHYLATED SPECIES: IMPLICATIONS FOR A CARCINOGENIC MECHANISM OF ACTION OF ARSENICALS

    EPA Science Inventory

    Direct-acting, DNA-damaging As (III)-methylated species: implications for a carcinogenic . mechanism of action of arsenicals

    Inorganic arsenic (iAs, arsenite and arsenate) has been thought to act as a carcinogen without reacting directly with DNA; neither iAs nor the As(...

  11. Neuronostatin inhibits glucose-stimulated insulin secretion via direct action on the pancreatic α-cell

    PubMed Central

    Salvatori, Alison S.; Elrick, Mollisa M.; Samson, Willis K.; Corbett, John A.

    2014-01-01

    Neuronostatin is a recently described peptide hormone encoded by the somatostatin gene. We previously showed that intraperitoneal injection of neuronostatin into mice resulted in c-Jun accumulation in pancreatic islets in a pattern consistent with the activation of glucagon-producing α-cells. We therefore hypothesized that neuronostatin could influence glucose homeostasis via a direct effect on the α-cell. Neuronostatin enhanced low-glucose-induced glucagon release in isolated rat islets and in the immortalized α-cell line αTC1-9. Furthermore, incubation with neuronostatin led to an increase in transcription of glucagon mRNA, as determined by RT-PCR. Neuronostatin also inhibited glucose-stimulated insulin secretion from isolated islets. However, neuronostatin did not alter insulin release from the β-cell line INS 832/13, indicating that the effect of neuronostatin on insulin secretion may be secondary to a direct action on the α-cell. In agreement with our in vitro data, intra-arterial infusion of neuronostatin in male rats delayed glucose disposal and inhibited insulin release during a glucose challenge. These studies suggest that neuronostatin participates in maintaining glucose homeostasis through cell-cell interactions between α-cells and β-cells in the endocrine pancreas, leading to attenuation in insulin secretion. PMID:24735892

  12. Direct inhibition of arcuate proopiomelanocortin neurons: a potential mechanism for the orexigenic actions of dynorphin

    PubMed Central

    Zhang, Xiaobing; van den Pol, Anthony N

    2013-01-01

    Dynorphin, an endogenous ligand of kappa (κ) opioid receptors, has multiple roles in the brain, and plays a positive role in energy balance and food intake. However, the mechanism for this is unclear. With immunocytochemistry, we find that axonal dynorphin immunoreactivity in the arcuate nucleus is strong, and that a large number of dynorphin-immunoreactive boutons terminate on or near anorexigenic proopiomelanocortin (POMC) cells. Here we provide evidence from whole-cell patch-clamp recording that dynorphin-A (Dyn-A) directly and dose-dependently inhibits arcuate nucleus POMC neurons. Dyn-A inhibition was eliminated by the κ opioid receptor antagonist nor-BNI, but not by the μ receptor antagonist CTAP. The inhibitory effect was mimicked by the κ2 receptor agonist GR89696, but not by the κ1 receptor agonist U69593. No presynaptic effect of κ2 agonists was found. These results suggest that Dyn-A inhibits POMC neurons through activation of the κ2 opioid receptor. In whole-cell voltage clamp, Dyn-A opened G-protein-coupled inwardly rectifying potassium (GIRK)-like channels on POMC neurons. Dynorphin attenuated glutamate and GABA neurotransmission to POMC neurons. In contrast to the strong inhibition of POMC neurons by Dyn-A, we found a weaker direct inhibitory effect of Dyn-A on arcuate nucleus neuropeptide Y (NPY) neurons mediated by both κ1 and κ2 receptors. Taken together, these results indicate a direct inhibitory effect of Dyn-A on POMC neurons through activation of the κ2 opioid receptor and GIRK channels. A number of orexigenic hypothalamic neurons release dynorphin along with other neuropeptides. The inhibition of anorexigenic POMC neurons may be one mechanism underlying the orexigenic actions of dynorphin. PMID:23318874

  13. Direct comparisons of hand and mouth kinematics during grasping, feeding and fork-feeding actions

    PubMed Central

    Quinlan, D. J.; Culham, J. C.

    2015-01-01

    While a plethora of studies have examined the kinematics of human reach-to-grasp actions, few have investigated feeding, another ethologically important real-world action. Two seminal studies concluded that the kinematics of the mouth during feeding are comparable to those of the hand during grasping (Castiello, 1997; Churchill et al., 1999); however, feeding was done with a fork or spoon, not with the hand itself. Here, we directly compared grasping and feeding kinematics under equivalent conditions. Participants were presented with differently sized cubes of cheese (10-, 20- or 30-mm on each side) and asked to use the hand to grasp them or to use a fork to spear them and then bring them to the mouth to bite. We measured the apertures of the hand during grasping and the teeth during feeding, as well as reaching kinematics of the arm in both tasks. As in many past studies, we found that the hand oversized considerably larger (~11–27 mm) than the food item during grasping; moreover, the amount of oversizing scaled with food size. Surprisingly, regardless of whether the hand or fork was used to transport the food, the mouth oversized only slightly larger (~4–11 mm) than the food item during biting and the oversizing did not increase with food size. Total movement times were longer when using the fork compared to the hand, particularly when using the fork to bring food to the mouth. While reach velocity always peaked approximately halfway through the movement, relative to the reach the mouth opened more slowly than the hand, perhaps because less time was required for the smaller oversizing. Taken together, our results show that while many aspects of kinematics share some similarity between grasping and feeding, oversizing may reflect strategies unique to the hand vs. mouth (such as the need to have the digits approach the target surface perpendicularly for grip stability during lifting) and differences in the neural substrates of grasping and feeding. PMID

  14. Searching for New Directions: Developing MA Action Research Project as a Tool for Teaching

    ERIC Educational Resources Information Center

    Lee, Young Ah; Wang, Ye

    2012-01-01

    Action research has been recognized as a useful professional development tool for teaching, but for inservice teachers, conducting action research can be challenging. Their learning about action research can be influenced by social situations--whether in an MA (Master of Arts) program or other professional development. The purpose of this…

  15. Similarities and Distinctions in Actions of Surface-Directed and Classic Androgen Receptor Antagonists.

    PubMed

    Suh, Ji Ho; Chattopadhyay, Arundhati; Sieglaff, Douglas H; Storer Samaniego, Cheryl; Cox, Marc B; Webb, Paul

    2015-01-01

    The androgen receptor (AR) surface-directed antagonist MJC13 inhibits AR function and proliferation of prostate cancer (PC) cells. These effects are related to arrest of an AR/chaperone complex in the cytoplasm. Here, we compared MJC13 and classic AR antagonists such as flutamide and bicalutamide. Microarray analysis and confirmatory qRT-PCR reveals that MJC13 and flutamide inhibit dihydrotestosterone (DHT)-dependent genes in LNCaP PC cells. Both compounds are equally effective on a genome wide basis and as effective as second generation AR antagonists (MDV3100, ARN-509) at selected genes. MJC13 inhibits AR binding to the prostate specific antigen (PSA) promoter more strongly than flutamide, consistent with different mechanisms of action. Examination of efficacy of MJC13 in conditions that reflect aspects castrate resistant prostate cancer (CRPC) reveals that it inhibits flutamide activation of an AR mutant (ART877A) that emerges during flutamide withdrawal syndrome, but displays greatly restricted gene-specific activity in 22Rv1 cells that express a constitutively active truncated AR and is inactive against glucocorticoid receptor (GR), which can co-opt androgen-dependent signaling networks in CRPC. Importantly, MJC13 inhibits AR interactions with SRC2 and β-catenin in the nucleus and, unlike flutamide, strongly inhibits amplification of AR activity obtained with transfected SRC2 and β-catenin. MJC13 also inhibits DHT and β-catenin-enhanced cell division in LNCaP cells. Thus, a surface-directed antagonist can block AR activity in some conditions in which a classic antagonist fails and may display utility in particular forms of CRPC.

  16. An Analysis of Sales Training Effectiveness within the Housing Market

    ERIC Educational Resources Information Center

    Ronbinson, John Cheney, IV

    2012-01-01

    The purpose of this study was to assess the performance outcomes of a sales training program. This study is unique in a number of ways. First, it focuses on an under-studied area (sales training effectiveness). Second, it is directed at the evaluation of sales training programs completed by Realtors within the housing industry. Finally, it…

  17. 27 CFR 10.24 - Sales promotion contests.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Sales promotion contests..., DEPARTMENT OF THE TREASURY LIQUORS COMMERCIAL BRIBERY Commercial Bribery § 10.24 Sales promotion contests. Sales contests sponsored by an industry member which offer prizes directly or indirectly to trade...

  18. 48 CFR 245.604-3 - Sale of surplus property.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Disposal 245.604-3 Sale of surplus property. (a) Plant clearance officers shall determine a best value..., e.g., potential sales proceeds. (b) Informal bid procedures. The plant clearance officer may direct... (3) Informal bids are confirmed in writing. (c) Sale approval and award. Plant clearance...

  19. 48 CFR 245.604-3 - Sale of surplus property.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Disposal 245.604-3 Sale of surplus property. (a) Plant clearance officers shall determine a best value..., e.g., potential sales proceeds. (b) Informal bid procedures. The plant clearance officer may direct... (3) Informal bids are confirmed in writing. (c) Sale approval and award. Plant clearance...

  20. Action Direction of Muscle Synergies in Three-Dimensional Force Space

    PubMed Central

    Hagio, Shota; Kouzaki, Motoki

    2015-01-01

    Redundancy in the musculoskeletal system was supposed to be simplified by muscle synergies, which modularly organize muscles. To clarify the underlying mechanisms of motor control using muscle synergies, it is important to examine the spatiotemporal contribution of muscle synergies in the task space. In this study, we quantified the mechanical contribution of muscle synergies as considering spatiotemporal correlation between the activation of muscle synergies and endpoint force fluctuations. Subjects performed isometric force generation in the three-dimensional force space. The muscle-weighting vectors of muscle synergies and their activation traces across different trials were extracted from electromyogram data using decomposing technique. We then estimated mechanical contribution of muscle synergies across each trial based on cross-correlation analysis. The contributing vectors were averaged for all trials, and the averaging was defined as action direction (AD) of muscle synergies. As a result, we extracted approximately five muscle synergies. The ADs of muscle synergies mainly depended on the anatomical functions of their weighting muscles. Furthermore, the AD of each muscle indicated the synchronous activation of muscles, which composed of the same muscle synergy. These results provide the spatiotemporal characteristics of muscle synergies as neural basis. PMID:26618156

  1. Nutrient Sensor in the Brain Directs the Action of the Brain-Gut Axis in Drosophila

    PubMed Central

    Dus, Monica; Sih-Yu Lai, Jason; Gunapala, Keith M.; Min, Soohong; Tayler, Timothy D.; Hergarden, Anne C.; Geraud, Eliot; Joseph, Christina M.; Suh, Greg S. B.

    2015-01-01

    Summary Animals can detect and consume nutritive sugars without the influence of taste. However, the identity of the taste-independent nutrient sensor and the mechanism by which animals respond to the nutritional value of sugar are unclear. Here, we report that six neurosecretory cells in the Drosophila brain that produce Diuretic hormone 44 (Dh44), a homologue of the mammalian corticotropin-releasing hormone (CRH), were specifically activated by nutritive sugars. Flies in which the activity of these neurons or the expression of Dh44 was disrupted failed to select nutritive sugars. Manipulation of the function of Dh44 receptors had a similar effect. Notably, artificial activation of Dh44 receptor-1 neurons resulted in proboscis extensions, and frequent episodes of excretion. Conversely, reduced Dh44 activity led to decreased excretion. Together, these actions facilitate ingestion and digestion of nutritive foods. We propose that the Dh44 system directs the detection and consumption of nutritive sugars through a positive feedback loop. PMID:26074004

  2. 7 CFR 930.16 - Sales constituency.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE TART CHERRIES GROWN IN THE STATES OF... consignments of cherries and does not direct where the consigned cherries are sold is not a sales constituency....

  3. 7 CFR 930.16 - Sales constituency.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE TART CHERRIES GROWN IN THE STATES OF... consignments of cherries and does not direct where the consigned cherries are sold is not a sales constituency....

  4. 7 CFR 930.16 - Sales constituency.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE TART CHERRIES GROWN IN THE STATES OF... consignments of cherries and does not direct where the consigned cherries are sold is not a sales constituency....

  5. Enhanced Neural Processing of Goal-directed Actions After Active Training in 4-Month-Old Infants.

    PubMed

    Bakker, Marta; Sommerville, Jessica A; Gredebäck, Gustaf

    2016-03-01

    The current study explores the neural correlates of action perception and its relation to infants' active experience performing goal-directed actions. Study 1 provided active training with sticky mittens that enables grasping and object manipulation in prereaching 4-month-olds. After training, EEG was recorded while infants observed images of hands grasping toward (congruent) or away from (incongruent) objects. We demonstrate that brief active training facilitates social perception as indexed by larger amplitude of the P400 ERP component to congruent compared with incongruent trials. Study 2 presented 4-month-old infants with passive training in which they observed an experimenter perform goal-directed reaching actions, followed by an identical ERP session to that used in Study 1. The second study did not demonstrate any differentiation between congruent and incongruent trials. These results suggest that (1) active experience alters the brains' response to goal-directed actions performed by others and (2) visual exposure alone is not sufficient in developing the neural networks subserving goal processing during action observation in infancy.

  6. Transcranial Direct Current Stimulation of the Motor Cortex Biases Action Choice in a Perceptual Decision Task.

    PubMed

    Javadi, Amir-Homayoun; Beyko, Angeliki; Walsh, Vincent; Kanai, Ryota

    2015-11-01

    One of the multiple interacting systems involved in the selection and execution of voluntary actions is the primary motor cortex (PMC). We aimed to investigate whether the transcranial direct current stimulation (tDCS) of this area can modulate hand choice. A perceptual decision-making task was administered. Participants were asked to classify rectangles with different height-to-width ratios into horizontal and vertical rectangles using their right and left index fingers while their PMC was stimulated either bilaterally or unilaterally. Two experiments were conducted with different stimulation conditions: the first experiment (n = 12) had only one stimulation condition (bilateral stimulation), and the second experiment (n = 45) had three stimulation conditions (bilateral, anodal unilateral, and cathodal unilateral stimulations). The second experiment was designed to confirm the results of the first experiment and to further investigate the effects of anodal and cathodal stimulations alone in the observed effects. Each participant took part in two sessions. The laterality of stimulation was reversed over the two sessions. Our results showed that anodal stimulation of the PMC biases participants' responses toward using the contralateral hand whereas cathodal stimulation biases responses toward the ipsilateral hand. Brain stimulation also modulated the RT of the left hand in all stimulation conditions: Responses were faster when the response bias was in favor of the left hand and slower when the response bias was against it. We propose two possible explanations for these findings: the perceptual bias account (bottom-up effects of stimulation on perception) and the motor-choice bias account (top-down modulation of the decision-making system by facilitation of response in one hand over the other). We conclude that motor responses and the choice of hand can be modulated using tDCS. PMID:26151605

  7. Direct Visualization of the Action of Triton X-100 on Giant Vesicles of Erythrocyte Membrane Lipids

    PubMed Central

    Casadei, Bruna R.; Domingues, Cleyton C.; de Paula, Eneida; Riske, Karin A.

    2014-01-01

    The raft hypothesis proposes that microdomains enriched in sphingolipids, cholesterol, and specific proteins are transiently formed to accomplish important cellular tasks. Equivocally, detergent-resistant membranes were initially assumed to be identical to membrane rafts, because of similarities between their compositions. In fact, the impact of detergents in membrane organization is still controversial. Here, we use phase contrast and fluorescence microscopy to observe giant unilamellar vesicles (GUVs) made of erythrocyte membrane lipids (erythro-GUVs) when exposed to the detergent Triton X-100 (TX-100). We clearly show that TX-100 has a restructuring action on biomembranes. Contact with TX-100 readily induces domain formation on the previously homogeneous membrane of erythro-GUVs at physiological and room temperatures. The shape and dynamics of the formed domains point to liquid-ordered/liquid-disordered (Lo/Ld) phase separation, typically found in raft-like ternary lipid mixtures. The Ld domains are then separated from the original vesicle and completely solubilized by TX-100. The insoluble vesicle left, in the Lo phase, represents around 2/3 of the original vesicle surface at room temperature and decreases to almost 1/2 at physiological temperature. This chain of events could be entirely reproduced with biomimetic GUVs of a simple ternary lipid mixture, 2:1:2 POPC/SM/chol (phosphatidylcholine/sphyngomyelin/cholesterol), showing that this behavior will arise because of fundamental physicochemical properties of simple lipid mixtures. This work provides direct visualization of TX-100-induced domain formation followed by selective (Ld phase) solubilization in a model system with a complex biological lipid composition. PMID:24896120

  8. Numeric removal action levels for contaminated drinking water sites. Update 2. Directive

    SciTech Connect

    1995-03-01

    This document is an updated table of numeric action levels for contaminated drinking water sites. It was originally published as an attachment to 9360.1-02 (Oct. 93) which described the new methodology used by OERR to calculate removal action levels (RALs) in drinking water.

  9. University Hospitals for Sale.

    ERIC Educational Resources Information Center

    Culliton, Barbara J.

    1984-01-01

    Although faculty opposition stopped the sale of Harvard's McLean Hospital to the Hospital Corporation of America (HCA), a partnership remains a possibility. Issues related to the proposed sale as well as those affecting hospital economics are considered. Proposed terms of the sale are included. (JN)

  10. CAN-DOO: The Climate Action Network through Direct Observations and Outreach

    NASA Astrophysics Data System (ADS)

    Taubman, B.; Sherman, J. P.; Perry, L. B.; Markham, J.; Kelly, G.

    2011-12-01

    The urgency of climate change demands a greater understanding of our climate system, not only by the leaders of today, but by the scientists, policy makers, and citizens of tomorrow. Unfortunately, a large segment of the population currently possesses inadequate knowledge of climate science. In direct response to a need for greater scientific literacy with respect to climate science, researchers from Appalachian State University's Appalachian Atmospheric Interdisciplinary Research (AppalAIR) group, with support from NASA, have developed CAN-DOO: the Climate Action Network through Direct Observations and Outreach. CAN-DOO addresses climate science literacy by 1) Developing the infrastructure for sustaining and expanding public outreach through long-term climate measurements capable of complementing existing NASA measurements, 2) Enhancing public awareness of climate science and NASA's role in advancing our understanding of the Earth System, and 3) Introducing Science, Technology, Engineering, and Mathematics principles to homeschooled, public school, and Appalachian State University students through applied climate science activities. Project partners include the Grandfather Mountain Stewardship Foundation, Pisgah Astronomical Research Institute, and local elementary schools. In partnership with Grandfather Mountain, climate science awareness is promoted through citizen science activities, interactive public displays, and staff training. CAN-DOO engages students by involving them in the entire scientific investigative process as applied to climate science. We introduce local elementary and middle school students, homeschooled students throughout North Carolina, and undergraduate students in a new Global Climate Change course and select other courses at Appalachian State University to instrument assembly, measurement techniques, data collection, hypothesis testing, and drawing conclusions. Results are placed in the proper context via comparisons with other student

  11. Action Type and Goal Type Modulate Goal-Directed Gaze Shifts in 14-Month-Old Infants

    ERIC Educational Resources Information Center

    Gredeback, Gustaf; Stasiewicz, Dorota; Falck-Ytter, Terje; von Hofsten, Claes; Rosander, Kerstin

    2009-01-01

    Ten- and 14-month-old infants' gaze was recorded as the infants observed videos of different hand actions directed toward multiple goals. Infants observed an actor who (a) reached for objects and displaced them, (b) reached for objects and placed them inside containers, or (c) moved his fisted hand. Fourteen-month-olds, but not 10-month-olds,…

  12. Fuel oil and kerosene sales 1994

    SciTech Connect

    1995-09-27

    This publication contains the 1994 survey results of the ``Annual Fuel Oil and Kerosene Sales Report`` (Form EIA-821). This is the sixth year that the survey data have appeared in a separate publication. Prior to the 1989 report, the statistics appeared in the Petroleum Marketing Annual (PMA)for reference year 1988 and the Petroleum Marketing Monthly (PMM) for reference years 1984 through 1987. The 1994 edition marks the 11th annual presentation of the results of the ongoing ``Annual Fuel Oil and Kerosene Sales Report`` survey. Distillate and residual fuel oil sales continued to move in opposite directions during 1994. Distillate sales rose for the third year in a row, due to a growing economy. Residual fuel oil sales, on the other hand, declined for the sixth year in a row, due to competitive natural gas prices, and a warmer heating season than in 1993. Distillate fuel oil sales increased 4.4 percent while residual fuel oil sales declined 1.6 percent. Kerosene sales decreased 1.4 percent in 1994.

  13. Development of goal-directed action selection guided by intrinsic motivations: an experiment with children.

    PubMed

    Taffoni, Fabrizio; Tamilia, Eleonora; Focaroli, Valentina; Formica, Domenico; Ricci, Luca; Di Pino, Giovanni; Baldassarre, Gianluca; Mirolli, Marco; Guglielmelli, Eugenio; Keller, Flavio

    2014-07-01

    Action selection is extremely important, particularly when the accomplishment of competitive tasks may require access to limited motor resources. The spontaneous exploration of the world plays a fundamental role in the development of this capacity, providing subjects with an increasingly diverse set of opportunities to acquire, practice and refine the understanding of action-outcome connection. The computational modeling literature proposed a number of specific mechanisms for autonomous agents to discover and target interesting outcomes: intrinsic motivations hold a central importance among those mechanisms. Unfortunately, the study of the acquisition of action-outcome relation was mostly carried out with experiments involving extrinsic tasks, either based on rewards or on predefined task goals. This work presents a new experimental paradigm to study the effect of intrinsic motivation on action-outcome relation learning and action selection during free exploration of the world. Three- and four-year-old children were observed during the free exploration of a new toy: half of them were allowed to develop the knowledge concerning its functioning; the other half were not allowed to learn anything. The knowledge acquired during the free exploration of the toy was subsequently assessed and compared. PMID:24691755

  14. The sales learning curve.

    PubMed

    Leslie, Mark; Holloway, Charles A

    2006-01-01

    When a company launches a new product into a new market, the temptation is to immediately ramp up sales force capacity to gain customers as quickly as possible. But hiring a full sales force too early just causes the firm to burn through cash and fail to meet revenue expectations. Before it can sell an innovative product efficiently, the entire organization needs to learn how customers will acquire and use it, a process the authors call the sales learning curve. The concept of a learning curve is well understood in manufacturing. Employees transfer knowledge and experience back and forth between the production line and purchasing, manufacturing, engineering, planning, and operations. The sales learning curve unfolds similarly through the give-and-take between the company--marketing, sales, product support, and product development--and its customers. As customers adopt the product, the firm modifies both the offering and the processes associated with making and selling it. Progress along the manufacturing curve is measured by tracking cost per unit: The more a firm learns about the manufacturing process, the more efficient it becomes, and the lower the unit cost goes. Progress along the sales learning curve is measured in an analogous way: The more a company learns about the sales process, the more efficient it becomes at selling, and the higher the sales yield. As the sales yield increases, the sales learning process unfolds in three distinct phases--initiation, transition, and execution. Each phase requires a different size--and kind--of sales force and represents a different stage in a company's production, marketing, and sales strategies. Adjusting those strategies as the firm progresses along the sales learning curve allows managers to plan resource allocation more accurately, set appropriate expectations, avoid disastrous cash shortfalls, and reduce both the time and money required to turn a profit.

  15. Understanding what your sales manager is up against.

    PubMed

    Trailer, Barry; Dickie, Jim

    2006-01-01

    Every year, the research firm CSO Insights publishes the results of its Sales Performance Optimization survey, an online questionnaire given to more than 1,000 sales executives worldwide that seeks to examine the effectiveness of key sales practices and metrics. In this article, two partners from CSO provide the 2005 and 2006 survey highlights, which describe the challenges today's sales organizations face and how they're responding. An overall theme is the degree to which the buy cycle has gotten out of sync with the sell cycle. Buyers have always had a buy cycle, starting at the point they perceive a need. Sellers have always had a sales cycle, starting at the point they spot a prospect. Traditionally, the two have dovetailed--either because the seller created the buyer's perception of need or because the buyer pursued a need by contacting a salesperson (often for product information). Now the buy cycle is often well under way before the seller is even aware there is a cycle--in part because of the information asymmetry created by the Internet. The implications for managing a sales organization are profound in that sales training must now address how reps handle an environment in which buyers have more knowledge than they do. The authors offer evidence that sales executives are taking--and should take--aggressive action to train and retain sales talent, manage the sales process, and use sales support technologies to meet the challenges of this new environment.

  16. 76 FR 18240 - Notice of Competitive Coal Lease Sale, Wyoming

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-01

    ... Bureau of Land Management Notice of Competitive Coal Lease Sale, Wyoming AGENCY: Bureau of Land Management, Interior. ACTION: Notice of competitive coal lease sale. SUMMARY: Notice is hereby given that certain coal resources in the West Antelope II South Coal Tract described below in Converse...

  17. 76 FR 11258 - Notice of Competitive Coal Lease Sale, Wyoming

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ... Bureau of Land Management Notice of Competitive Coal Lease Sale, Wyoming AGENCY: Bureau of Land Management, Interior. ACTION: Notice of Competitive Coal Lease Sale. SUMMARY: Notice is hereby given that certain coal resources in the West Antelope II North Coal Tract described below in Campbell...

  18. 76 FR 64099 - Notice of Competitive Coal Lease Sale, Wyoming

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-17

    ... Bureau of Land Management Notice of Competitive Coal Lease Sale, Wyoming AGENCY: Bureau of Land Management, Interior. ACTION: Notice of competitive coal lease sale. SUMMARY: Notice is hereby given that certain coal resources in the South Hilight Field Coal Tract described below in Campbell County,...

  19. 76 FR 35465 - Notice of Competitive Coal Lease Sale, Wyoming

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-17

    ... Bureau of Land Management Notice of Competitive Coal Lease Sale, Wyoming AGENCY: Bureau of Land Management, Interior. ACTION: Notice of competitive coal lease sale. SUMMARY: Notice is hereby given that certain coal resources in the Caballo West Coal Tract described below in Campbell County, Wyoming, will...

  20. 76 FR 63951 - Notice of Competitive Coal Lease Sale, Utah

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-14

    ... November 7, 2005, are subject to cost recovery on a case-by-case basis (See 43 CFR 3000.10(d)(1), 70 FR... Bureau of Land Management Notice of Competitive Coal Lease Sale, Utah AGENCY: Bureau of Land Management, Interior. ACTION: Notice of competitive coal lease sale. SUMMARY: Notice is hereby given that that...

  1. 77 FR 40630 - Notice of Competitive Coal Lease Sale, Colorado

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-10

    ... Bureau of Land Management Notice of Competitive Coal Lease Sale, Colorado AGENCY: Bureau of Land Management, Interior. ACTION: Notice of competitive coal lease sale. SUMMARY: Notice is hereby given that certain coal reserves in the Wadge Seam described below in Routt County, Colorado, will be offered...

  2. 77 FR 21803 - Notice of Competitive Coal Lease Sale, Colorado

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ... Bureau of Land Management Notice of Competitive Coal Lease Sale, Colorado AGENCY: Bureau of Land Management, Interior. ACTION: Notice. SUMMARY: Notice is hereby given that certain coal reserves in the Elk... receive a reply during normal business hours. SUPPLEMENTARY INFORMATION: This coal lease sale is...

  3. The Charlotte Action Research Project: A Model for Direct and Mutually Beneficial Community-University Engagement

    ERIC Educational Resources Information Center

    Morrell, Elizabeth; Sorensen, Janni; Howarth, Joe

    2015-01-01

    This article describes the evolution of the Charlotte Action Research Project (CHARP), a community-university partnership founded in 2008 at the University of North Carolina at Charlotte, and focuses particularly on the program's unique organizational structure. Research findings of a project evaluation suggest that the CHARP model's unique…

  4. Action-Specific Influences on Perception and Post-Perceptual Processes: Present Controversies and Future Directions

    PubMed Central

    Philbeck, John W.; Witt, Jessica K.

    2015-01-01

    The action-specific perception account holds that people perceive the environment in terms of their ability to act in it. In this view, for example, decreased ability to climb a hill due to fatigue makes the hill visually appear to be steeper. Though influential, this account has not been universally accepted, and in fact a heated controversy has emerged. The opposing view holds that action capability has little or no influence on perception. Heretofore, the debate has been quite polarized, with efforts largely being focused on supporting one view and dismantling the other. We argue here that polarized debate can impede scientific progress and that the search for similarities between two sides of a debate can sharpen the theoretical focus of both sides and illuminate important avenues for future research. In this paper, we present a synthetic review of this debate, drawing from the literatures of both approaches, to clarify both the surprising similarities and the core differences between them. We critically evaluate existing evidence, discuss possible mechanisms of action-specific effects, and make recommendations for future research. A primary focus of future work will involve not only the development of methods that guard against action-specific post-perceptual effects, but also development of concrete, well-constrained underlying mechanisms. The criteria for what constitutes acceptable control of post-perceptual effects and what constitutes an appropriately specific mechanism vary between approaches, and bridging this gap is a central challenge for future research. PMID:26501227

  5. Direct Perception of Action-Scaled Affordances: The Shrinking Gap Problem

    ERIC Educational Resources Information Center

    Fajen, Brett R.; Matthis, Jonathan S.

    2011-01-01

    The aim of this study was to investigate the perception of possibilities for action (i.e., affordances) that depend on one's movement capabilities, and more specifically, the passability of a shrinking gap between converging obstacles. We introduce a new optical invariant that specifies in intrinsic units the minimum locomotor speed needed to…

  6. Final guidance on numeric removal action levels for contaminated drinking water sites. Directive

    SciTech Connect

    1993-10-01

    The purpose of this memorandum is to transmit the final OERR methodology and guidance on the calculation of numeric removal action levels (RALs), to assist Superfund personnel in deciding whether to provide alternate sources of drinking water to populations adversely affected by releases of hazardous substances into the environment.

  7. The cognition-enhancing effects of psychostimulants involve direct action in the prefrontal cortex.

    PubMed

    Spencer, Robert C; Devilbiss, David M; Berridge, Craig W

    2015-06-01

    Psychostimulants are highly effective in the treatment of attention-deficit/hyperactivity disorder. The clinical efficacy of these drugs is strongly linked to their ability to improve cognition dependent on the prefrontal cortex (PFC) and extended frontostriatal circuit. The procognitive actions of psychostimulants are only associated with low doses. Surprisingly, despite nearly 80 years of clinical use, the neurobiology of the procognitive actions of psychostimulants has only recently been systematically investigated. Findings from this research unambiguously demonstrate that the cognition-enhancing effects of psychostimulants involve the preferential elevation of catecholamines in the PFC and the subsequent activation of norepinephrine α2 and dopamine D1 receptors. In contrast, while the striatum is a critical participant in PFC-dependent cognition, where examined, psychostimulant action within the striatum is not sufficient to enhance cognition. At doses that moderately exceed the clinical range, psychostimulants appear to improve PFC-dependent attentional processes at the expense of other PFC-dependent processes (e.g., working memory, response inhibition). This differential modulation of PFC-dependent processes across dose appears to be associated with the differential involvement of noradrenergic α2 versus α1 receptors. Collectively, this evidence indicates that at low, clinically relevant doses, psychostimulants are devoid of the behavioral and neurochemical actions that define this class of drugs and instead act largely as cognitive enhancers (improving PFC-dependent function). This information has potentially important clinical implications as well as relevance for public health policy regarding the widespread clinical use of psychostimulants and for the development of novel pharmacologic treatments for attention-deficit/hyperactivity disorder and other conditions associated with PFC dysregulation.

  8. The cognition-enhancing effects of psychostimulants involve direct action in the prefrontal cortex.

    PubMed

    Spencer, Robert C; Devilbiss, David M; Berridge, Craig W

    2015-06-01

    Psychostimulants are highly effective in the treatment of attention-deficit/hyperactivity disorder. The clinical efficacy of these drugs is strongly linked to their ability to improve cognition dependent on the prefrontal cortex (PFC) and extended frontostriatal circuit. The procognitive actions of psychostimulants are only associated with low doses. Surprisingly, despite nearly 80 years of clinical use, the neurobiology of the procognitive actions of psychostimulants has only recently been systematically investigated. Findings from this research unambiguously demonstrate that the cognition-enhancing effects of psychostimulants involve the preferential elevation of catecholamines in the PFC and the subsequent activation of norepinephrine α2 and dopamine D1 receptors. In contrast, while the striatum is a critical participant in PFC-dependent cognition, where examined, psychostimulant action within the striatum is not sufficient to enhance cognition. At doses that moderately exceed the clinical range, psychostimulants appear to improve PFC-dependent attentional processes at the expense of other PFC-dependent processes (e.g., working memory, response inhibition). This differential modulation of PFC-dependent processes across dose appears to be associated with the differential involvement of noradrenergic α2 versus α1 receptors. Collectively, this evidence indicates that at low, clinically relevant doses, psychostimulants are devoid of the behavioral and neurochemical actions that define this class of drugs and instead act largely as cognitive enhancers (improving PFC-dependent function). This information has potentially important clinical implications as well as relevance for public health policy regarding the widespread clinical use of psychostimulants and for the development of novel pharmacologic treatments for attention-deficit/hyperactivity disorder and other conditions associated with PFC dysregulation. PMID:25499957

  9. Anticipating Intentional Actions: The Effect of Eye Gaze Direction on the Judgment of Head Rotation

    ERIC Educational Resources Information Center

    Hudson, Matthew; Liu, Chang Hong; Jellema, Tjeerd

    2009-01-01

    Using a representational momentum paradigm, this study investigated the hypothesis that judgments of how far another agent's head has rotated are influenced by the perceived gaze direction of the head. Participants observed a video-clip of a face rotating 60[degrees] towards them starting from the left or right profile view. The gaze direction of…

  10. From recording discrete actions to studying continuous goal-directed behaviours in team sports.

    PubMed

    Correia, Vanda; Araújo, Duarte; Vilar, Luís; Davids, Keith

    2013-01-01

    This paper highlights the importance of examining interpersonal interactions in performance analysis of team sports, predicated on the relationship between perception and action, compared to the traditional cataloguing of actions by individual performers. We discuss how ecological dynamics may provide a potential unifying theoretical and empirical framework to achieve this re-emphasis in research. With reference to data from illustrative studies on performance analysis and sport expertise, we critically evaluate some of the main assumptions and methodological approaches with regard to understanding how information influences action and decision-making during team sports performance. Current data demonstrate how the understanding of performance behaviours in team sports by sport scientists and practitioners may be enhanced with a re-emphasis in research on the dynamics of emergent ongoing interactions. Ecological dynamics provides formal and theoretically grounded descriptions of player-environment interactions with respect to key performance goals and the unfolding information of competitive performance. Developing these formal descriptions and explanations of sport performance may provide a significant contribution to the field of performance analysis, supporting design and intervention in both research and practice.

  11. 75 FR 55269 - Telemarketing Sales Rule Fees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-10

    ... CFR Part 310 RIN 3084-AA98 Telemarketing Sales Rule Fees AGENCY: Federal Trade Commission. ACTION... that there will be no increase in the fees charged to entities accessing the National Do Not Call.... SUPPLEMENTARY INFORMATION: The Do-Not-Call Registry Fee Extension Act of 2007 (Pub. L. 110-188, 122 Stat....

  12. [Development and consolidation of General Student Welfare Direction at National University of Cordoba: institutional actions directed to integrated student health. Decades of 1960-1970].

    PubMed

    Altamirano Bentolila, Patricia; Clark, Carmen; Stabile, Carmen

    2014-01-01

    Starting from historical records attempts to identify the events which made possible the creation and regulation of Welfare Student Department. A Decade of 60 and 70 was fruitful for starting and development of first institutional politics designed to attend the health and welfare of students. In that way, the actions of Welfare Student Direction and Vocational Guidance focus their objective to bring on welfare, permanence, development of university student. It stand out the accent put it on the integral health exam of students, the concern about the empty in his cultural training, the possibility of make it easier vocational support and the execution of health insurance.

  13. 38 CFR 36.4524 - Sale of loans.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Sale of loans. 36.4524 Section 36.4524 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) LOAN GUARANTY Direct Loans § 36.4524 Sale of loans. In the event a direct loan is purchased from the...

  14. 38 CFR 36.4524 - Sale of loans.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2012-07-01 2012-07-01 false Sale of loans. 36.4524 Section 36.4524 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) LOAN GUARANTY Direct Loans § 36.4524 Sale of loans. In the event a direct loan is purchased from the...

  15. Some Advertising Sales Tips.

    ERIC Educational Resources Information Center

    Schick, C. Dennis

    1980-01-01

    Enumerates information that advertising sales people for school newspapers should have before they call on potential customers. Includes ideas on what to know about a number of items, including the publication, readers and nonreaders, advertising, sales opportunities, prospects, prospects' problems, shopping factors, and stores' images. (TJ)

  16. Cellular and Molecular Mechanisms of Action of Transcranial Direct Current Stimulation: Evidence from In Vitro and In Vivo Models

    PubMed Central

    Pelletier, Simon J.

    2015-01-01

    Transcranial direct current stimulation is a noninvasive technique that has been experimentally tested for a number of psychiatric and neurological conditions. Preliminary observations suggest that this approach can indeed influence a number of cellular and molecular pathways that may be disease relevant. However, the mechanisms of action underlying its beneficial effects are largely unknown and need to be better understood to allow this therapy to be used optimally. In this review, we summarize the physiological responses observed in vitro and in vivo, with a particular emphasis on cellular and molecular cascades associated with inflammation, angiogenesis, neurogenesis, and neuroplasticity recruited by direct current stimulation, a topic that has been largely neglected in the literature. A better understanding of the neural responses to transcranial direct current stimulation is critical if this therapy is to be used in large-scale clinical trials with a view of being routinely offered to patients suffering from various conditions affecting the central nervous system. PMID:25522391

  17. Understanding Human Original Actions Directed at Real-World Goals: The Role of the Lateral Prefrontal Cortex

    PubMed Central

    Sitnikova, Tatiana; Rosen, Bruce R.; Lord, Louis-David; West, W. Caroline

    2014-01-01

    Adaptive, original actions, which can succeed in multiple contextual situations, require understanding of what is relevant to a goal. Recognizing what is relevant may also help in predicting kinematics of observed, original actions. During action observation, comparisons between sensory input and expected action kinematics have been argued critical to accurate goal inference. Experimental studies with laboratory tasks, both in humans and nonhuman primates, demonstrated that the lateral prefrontal cortex (LPFC) can learn, hierarchically organize, and use goal-relevant information. To determine whether this LPFC capacity is generalizable to real-world cognition, we recorded functional magnetic resonance imaging (fMRI) data in the human brain during comprehension of original and usual object-directed actions embedded in video-depictions of real-life behaviors. We hypothesized that LPFC will contribute to forming goal-relevant representations necessary for kinematic predictions of original actions. Additionally, resting-state fMRI was employed to examine functional connectivity between the brain regions delineated in the video fMRI experiment. According to behavioral data, original videos could be understood by identifying elements relevant to real-life goals at different levels of abstraction. Patterns of enhanced activity in four regions in the left LPFC, evoked by original, relative to usual, video scenes, were consistent with previous neuroimaging findings on representing abstract and concrete stimuli dimensions relevant to laboratory goals. In the anterior left LPFC, the activity increased selectively when representations of broad classes of objects and actions, which could achieve the perceived overall behavioral goal, were likely to bias kinematic predictions of original actions. In contrast, in the more posterior regions, the activity increased even when concrete properties of the target object were more likely to bias the kinematic prediction. Functional

  18. Is Agency Skin Deep? Surface Attributes Influence Infants' Sensitivity to Goal-Directed Action

    ERIC Educational Resources Information Center

    Guajardo, Jose J.; Woodward, Amanda L.

    2004-01-01

    Three studies investigated the role of surface attributes in infants' identification of agents, using a habituation paradigm designed to tap infants' interpretation of grasping as goal directed (Woodward, 1998). When they viewed a bare human hand grasping objects, 7- and 12-month-old infants focused on the relation between the hand and its goal.…

  19. 12 CFR 565.7 - Directives to take prompt corrective action.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... OTS's discretion to require or impose under section 38 of the FDI Act, including sections 38(e)(5), (f... directive. If the OTS finds it necessary in order to carry out the purposes of section 38 of the FDI Act... require or impose under section 38 of the FDI Act, including section 38(e)(5), (f)(2), (f)(3), or...

  20. They Sell Skulls Online?! A Review of Internet Sales of Human Skulls on eBay and the Laws in Place to Restrict Sales.

    PubMed

    Halling, Christine L; Seidemann, Ryan M

    2016-09-01

    Internet sales of human remains occur despite the existence of laws prohibiting such action in most jurisdictions. The most popular public platform for online sales, eBay, allows users to postskeletal material for sale, largely anonymously and without much fear of legal repercussions. This survey of skeletal sales was conducted 10 years after the first article published about online human remains sales. A review of current laws reveals that, while many states have laws that restrict any sale of human remains, those laws have questionable deterrent effect. Assessing the skeletal material posted for sale provides law enforcement agencies with a necessary starting point to curtail the sale of human remains through enforcement of existing laws. Ultimately, the goal is to stem the commodification of such items and to recover skeletal material, especially that which may be of archaeological or forensic significance, and provide the proper final disposition for such material. PMID:27373546

  1. Control of Inhibition by the Direct Action of Cannabinoids on GABAA Receptors.

    PubMed

    Golovko, Tatiana; Min, Rogier; Lozovaya, Natalia; Falconer, Caroline; Yatsenko, Natalia; Tsintsadze, Timur; Tsintsadze, Vera; Ledent, Catherine; Harvey, Robert J; Belelli, Delia; Lambert, Jeremy J; Rozov, Andrei; Burnashev, Nail

    2015-09-01

    Cannabinoids are known to regulate inhibitory synaptic transmission via activation of presynaptic G protein-coupled cannabinoid CB1 receptors (CB1Rs). Additionally, recent studies suggest that cannabinoids can also directly interact with recombinant GABAA receptors (GABAARs), potentiating currents activated by micromolar concentrations of γ-aminobutyric acid (GABA). However, the impact of this direct interaction on GABAergic inhibition in central nervous system is unknown. Here we report that currents mediated by recombinant GABAARs activated by high (synaptic) concentrations of GABA as well as GABAergic inhibitory postsynaptic currents (IPSCs) at neocortical fast spiking (FS) interneuron to pyramidal neuron synapses are suppressed by exogenous and endogenous cannabinoids in a CB1R-independent manner. This IPSC suppression may account for disruption of inhibitory control of pyramidal neurons by FS interneurons. At FS interneuron to pyramidal neuron synapses, endocannabinoids induce synaptic low-pass filtering of GABAAR-mediated currents evoked by high-frequency stimulation. The CB1R-independent suppression of inhibition is synapse specific. It does not occur in CB1R containing hippocampal cholecystokinin-positive interneuron to pyramidal neuron synapses. Furthermore, in contrast to synaptic receptors, the activity of extrasynaptic GABAARs in neocortical pyramidal neurons is enhanced by cannabinoids in a CB1R-independent manner. Thus, cannabinoids directly interact differentially with synaptic and extrasynaptic GABAARs, providing a potent novel context-dependent mechanism for regulation of inhibition.

  2. LXA{sub 4} actions direct fibroblast function and wound closure

    SciTech Connect

    Herrera, Bruno S.; Kantarci, Alpdogan; Zarrough, Ahmed; Hasturk, Hatice; Leung, Kai P.; Van Dyke, Thomas E.

    2015-09-04

    Timely resolution of inflammation is crucial for normal wound healing. Resolution of inflammation is an active biological process regulated by specialized lipid mediators including the lipoxins and resolvins. Failure of resolution activity has a major negative impact on wound healing in chronic inflammatory diseases that is manifest as excess fibrosis and scarring. Lipoxins, including Lipoxin A{sub 4} (LXA{sub 4}), have known anti-fibrotic and anti-scarring properties. The goal of this study was to elucidate the impact of LXA{sub 4} on fibroblast function. Mouse fibroblasts (3T3 Mus musculus Swiss) were cultured for 72 h in the presence of TGF-β1, to induce fibroblast activation. The impact of exogenous TGF-β1 (1 ng/mL) on LXA{sub 4} receptor expression (ALX/FPR2) was determined by flow cytometry. Fibroblast proliferation was measured by bromodeoxyuridine (BrdU) labeling and migration in a “scratch” assay wound model. Expression of α-smooth muscle actin (α-SMA), and collagen types I and III were measured by Western blot. We observed that TGF-β1 up-regulates LXA{sub 4} receptor expression, enhances fibroblast proliferation, migration and scratch wound closure. α-SMA levels and Collagen type I and III deposition were also enhanced. LXA{sub 4} slowed fibroblast migration and scratch wound closure at early time points (24 h), but wound closure was equal to TGF-β1 alone at 48 and 72 h. LXA{sub 4} tended to slow fibroblast proliferation at both concentrations, but had no impact on α-SMA or collagen production by TGF-β1 stimulated fibroblasts. The generalizability of the actions of resolution molecules was examined in experiments repeated with resolvin D2 (RvD2) as the agonist. The activity of RvD2 mimicked the actions of LXA{sub 4} in all assays, through an as yet unidentified receptor. The results suggest that mediators of resolution of inflammation enhance wound healing and limit fibrosis in part by modulating fibroblast function. - Highlights: • TGF

  3. Marketing/Sales Students' Understanding of What Counts as Sales

    ERIC Educational Resources Information Center

    Hoshower, Leon; Gupta, Ashok K.

    2009-01-01

    Improper sales revenue recognition is the single largest issue contributing to financial restatements. Understanding and applying the rules of sales revenue recognition is not just an accounting problem; it is a marketing problem, too. Thus, it is important that the sales force has a basic understanding of the rules of sales recognition and be…

  4. Direct Evidence for the Economy of Action: Glucose and the Perception of Geographical Slant

    PubMed Central

    Schnall, Simone; Zadra, Jonathan R.; Proffitt, Dennis R.

    2012-01-01

    When locomoting in a physically challenging environment, the body draws upon available energy reserves to accommodate increased metabolic demand. Ingested glucose supplements the body’s energy resources, whereas non-caloric sweetener does not. Two experiments demonstrate that participants who had consumed a glucose-containing drink perceived a hills slant to be less steep than did participants who had consumed a drink containing non-caloric sweetener. The glucose manipulation influenced participants’ explicit awareness of hill slant but, as predicted, it did not affect a visually-guided action of orienting a tilting palmboard to be parallel to the hill. Measured individual differences in factors related to bioenergetic state such as fatigue, sleep quality, fitness, mood, and stress also affected perception such that lower energetic states were associated with steeper perceptions of hill slant. This research shows that the perception of the environment’s spatial layout is influenced by the energetic resources available for locomotion within it. Our findings are consistent with the view that spatial perceptions are influenced by bioenergetic factors. PMID:20514996

  5. Sensitivity of locus ceruleus neurons to reward value for goal-directed actions.

    PubMed

    Bouret, Sebastien; Richmond, Barry J

    2015-03-01

    The noradrenergic nucleus locus ceruleus (LC) is associated classically with arousal and attention. Recent data suggest that it might also play a role in motivation. To study how LC neuronal responses are related to motivational intensity, we recorded 121 single neurons from two monkeys while reward size (one, two, or four drops) and the manner of obtaining reward (passive vs active) were both manipulated. The monkeys received reward under three conditions: (1) releasing a bar when a visual target changed color; (2) passively holding a bar; or (3) touching and releasing a bar. In the first two conditions, a visual cue indicated the size of the upcoming reward, and, in the third, the reward was constant through each block of 25 trials. Performance levels and lipping intensity (an appetitive behavior) both showed that the monkeys' motivation in the task was related to the predicted reward size. In conditions 1 and 2, LC neurons were activated phasically in relation to cue onset, and this activation strengthened with increasing expected reward size. In conditions 1 and 3, LC neurons were activated before the bar-release action, and the activation weakened with increasing expected reward size but only in task 1. These effects evolved as monkeys progressed through behavioral sessions, because increasing fatigue and satiety presumably progressively decreased the value of the upcoming reward. These data indicate that LC neurons integrate motivationally relevant information: both external cues and internal drives. The LC might provide the impetus to act when the predicted outcome value is low. PMID:25740528

  6. Institutional frameworks to direct development and implementation of great lakes remedial action plans

    NASA Astrophysics Data System (ADS)

    Hartig, John H.; Law, Neely

    1994-11-01

    Locally designed, institutional frameworks are being used to develop and implement remedial action plans (RAPs) to restore beneficial uses in 43 Great Lakes areas of concern. A 1993 Canada-United States roundtable was convened to learn from case studies and to develop recommendations regarding essential characteristics of RAP institutional frameworks, guidance to ensure linkages to other related plans, and ways of embracing new institutional frameworks from RAP development to implementation. Major roundtable recommendations are: (1) RAP institutional frameworks should be empowered to pursue their mission of restoring uses. Empowerment would be demonstrated by: a watershed focus, inclusive and shared decision-making, clear responsibilities and sufficient authority, creative funding capability, flexibility and continuity in the process, an iterative process of continuous improvement, and commitment to education and outreach. (2) RAP institutional frameworks should be used as mechanisms to coordinate programs at the local level. Such local coordination should be complemented with governmental commitments to intra- and interagency coordination in work plans. (3) RAP institutional frameworks can help build the capacity of governments to achieve their goals. Therefore, governments must adopt long-term, visionary goals and commit to a customer-driven RAP process of continuous improvement.

  7. INFORMAS (International Network for Food and Obesity/non-communicable diseases Research, Monitoring and Action Support): summary and future directions.

    PubMed

    Kumanyika, S

    2013-10-01

    This supplement presents the foundational elements for INFORMAS (International Network for Food and Obesity/non-communicable diseases Research, Monitoring and Action Support). As explained in the overview article by Swinburn and colleagues, INFORMAS has a compelling rationale and has set forth clear objectives, outcomes, principles and frameworks for monitoring and benchmarking key aspects of food environments and the policies and actions that influence the healthiness of food environments. This summary highlights the proposed monitoring approaches for the 10 interrelated INFORMAS modules: public and private sector policies and actions; key aspects of food environments (food composition, labelling, promotion, provision, retail, prices, and trade and investment) and population outcomes (diet quality). This ambitious effort should be feasible when approached in a step-wise manner, taking into account existing monitoring efforts, data sources, country contexts and capacity, and when adequately resourced. After protocol development and pilot testing of the modules, INFORMAS aims to be a sustainable, low-cost monitoring framework. Future directions relate to institutionalization, implementation and, ultimately, to leveraging INFORMAS data in ways that will bring key drivers of food environments into alignment with public health goals.

  8. Further evidence against a direct genotoxic mode of action for arsenic-induced cancer

    SciTech Connect

    Klein, Catherine B.; Leszczynska, Joanna; Hickey, Christina; Rossman, Toby G.

    2007-08-01

    Arsenic in drinking water, a mixture of arsenite and arsenate, is associated with increased skin and other cancers in Asia and Latin America, but not the United States. Arsenite alone in drinking water does not cause skin cancers in experimental animals; therefore, it is not a complete carcinogen in skin. We recently showed that low concentrations of arsenite enhanced the tumorigenicity of solar UV irradiation in hairless mice, suggesting arsenic cocarcinogenesis with sunlight in skin cancer and perhaps with different carcinogenic partners for lung and bladder tumors. Cocarcinogenic mechanisms could include blocking DNA repair, stimulating angiogenesis, altering DNA methylation patterns, dysregulating cell cycle control, induction of aneuploidy and blocking apoptosis. Arsenicals are documented clastogens but not strong mutagens, with weak mutagenic activity reported at highly toxic concentrations of inorganic arsenic. Previously, we showed that arsenite, but not monomethylarsonous acid (MMA[III]), induced delayed mutagenesis in HOS cells. Here, we report new data on the mutagenicity of the trivalent methylated arsenic metabolites MMA(III) and dimethylarsinous acid [DMA(III)] at the gpt locus in Chinese hamster G12 cells. Both methylated arsenicals seemed mutagenic with apparent sublinear dose responses. However, significant mutagenesis occurred only at highly toxic concentrations of MMA(III). Most mutants induced by MMA(III) and DMA(III) exhibited transgene deletions. Some non-deletion mutants exhibited altered DNA methylation. A critical discussion of cell survival leads us to conclude that clastogenesis occurs primarily at highly cytotoxic arsenic concentrations, casting further doubt as to whether a genotoxic mode of action (MOA) for arsenicals is supportable.

  9. Direct action of capsaicin in brown adipogenesis and activation of brown adipocytes.

    PubMed

    Kida, Ryosuke; Yoshida, Hirofumi; Murakami, Masaru; Shirai, Mitsuyuki; Hashimoto, Osamu; Kawada, Teruo; Matsui, Tohru; Funaba, Masayuki

    2016-01-01

    The ingestion of capsaicin, the principle pungent component of red and chili peppers, induces thermogenesis, in part, through the activation of brown adipocytes expressing genes related to mitochondrial biogenesis and uncoupling such as peroxisome proliferator-activated receptor (Ppar) γ coactivator-1α (Pgc-1α) and uncoupling protein 1 (Ucp1). Capsaicin has been suggested to induce the activation of brown adipocytes, which is mediated by the stimulation of sympathetic nerves. However, capsaicin may directly affect the differentiation of brown preadipocytes, brown adipocyte function, or both, through its significant absorption. We herein demonstrated that Trpv1, a capsaicin receptor, is expressed in brown adipose tissue, and that its expression level is increased during the differentiation of HB2 brown preadipocytes. Furthermore, capsaicin induced calcium influx in brown preadipocytes. A treatment with capsaicin in the early stage of brown adipogenesis did not affect lipid accumulation or the expression levels of Fabp4 (a gene expressed in mature adipocytes), Pparγ2 (a master regulator of adipogenesis) or brown adipocyte-selective genes. In contrast, a treatment with capsaicin in the late stage of brown adipogenesis slightly increased the expression levels of Fabp4, Pparγ2 and Pgc-1α. Although capsaicin did not affect the basal expression level of Ucp1, Ucp1 induction by forskolin was partially inhibited by capsaicin, irrespective of the dose of capsaicin. The results of the present study suggest the direct effects of capsaicin on brown adipocytes or in the late stage of brown adipogenesis. PMID:26781688

  10. Direct cytotoxic action of Shiga toxin on human vascular endothelial cells.

    PubMed Central

    Obrig, T G; Del Vecchio, P J; Brown, J E; Moran, T P; Rowland, B M; Judge, T K; Rothman, S W

    1988-01-01

    To help explain a role of the Shiga toxin family in hemorrhagic colitis and hemolytic-uremic syndrome in humans, it has been hypothesized that these toxins cause direct damage to the vascular endothelium. We now report that Shiga toxin purified from Shigella dysenteriae 1 does indeed have a direct cytotoxic effect on vascular endothelial cells in cultures. Human umbilical vein endothelial cells (HUVEC) in confluent monolayers were reduced 50% by 10(-8) M Shiga toxin after a lag period of 48 to 96 h. In comparison, nonconfluent HUVEC were reduced 50% by 10(-10) M Shiga toxin within a 24-h period. These data suggest that dividing endothelial cells are more sensitive to Shiga toxin than are quiescent cells in confluent monolayers. Both confluent and nonconfluent HUVEC specifically bound 125I-Shiga toxin. However, in response to the toxin, rates of incorporation of [3H]leucine into protein were more severely reduced in nonconfluent cells than in confluent cells. Toxin inhibition of protein synthesis preceded detachment of cells from the substratum. The specific binding of 125I-Shiga toxin to human endothelial cells and the cytotoxic response were both toxin dose dependent and neutralized by anti-Shiga toxin antibody. Heat-denatured Shiga toxin was without the cytotoxic effect. In addition, the complete culture system contained less than 0.1 ng of bacterial endotoxin per ml, as measured by the Limulus amoebocyte lysate test. PMID:3044997

  11. Direct action of capsaicin in brown adipogenesis and activation of brown adipocytes.

    PubMed

    Kida, Ryosuke; Yoshida, Hirofumi; Murakami, Masaru; Shirai, Mitsuyuki; Hashimoto, Osamu; Kawada, Teruo; Matsui, Tohru; Funaba, Masayuki

    2016-01-01

    The ingestion of capsaicin, the principle pungent component of red and chili peppers, induces thermogenesis, in part, through the activation of brown adipocytes expressing genes related to mitochondrial biogenesis and uncoupling such as peroxisome proliferator-activated receptor (Ppar) γ coactivator-1α (Pgc-1α) and uncoupling protein 1 (Ucp1). Capsaicin has been suggested to induce the activation of brown adipocytes, which is mediated by the stimulation of sympathetic nerves. However, capsaicin may directly affect the differentiation of brown preadipocytes, brown adipocyte function, or both, through its significant absorption. We herein demonstrated that Trpv1, a capsaicin receptor, is expressed in brown adipose tissue, and that its expression level is increased during the differentiation of HB2 brown preadipocytes. Furthermore, capsaicin induced calcium influx in brown preadipocytes. A treatment with capsaicin in the early stage of brown adipogenesis did not affect lipid accumulation or the expression levels of Fabp4 (a gene expressed in mature adipocytes), Pparγ2 (a master regulator of adipogenesis) or brown adipocyte-selective genes. In contrast, a treatment with capsaicin in the late stage of brown adipogenesis slightly increased the expression levels of Fabp4, Pparγ2 and Pgc-1α. Although capsaicin did not affect the basal expression level of Ucp1, Ucp1 induction by forskolin was partially inhibited by capsaicin, irrespective of the dose of capsaicin. The results of the present study suggest the direct effects of capsaicin on brown adipocytes or in the late stage of brown adipogenesis.

  12. Motor planning of goal-directed action is tuned by the emotional valence of the stimulus: a kinematic study

    PubMed Central

    Esteves, P. O.; Oliveira, L. A. S.; Nogueira-Campos, A. A.; Saunier, G.; Pozzo, T.; Oliveira, J. M.; Rodrigues, E. C.; Volchan, E.; Vargas, C. D.

    2016-01-01

    The basic underpinnings of homeostatic behavior include interacting with positive items and avoiding negative ones. As the planning aspects of goal-directed actions can be inferred from their movement features, we investigated the kinematics of interacting with emotion-laden stimuli. Participants were instructed to grasp emotion-laden stimuli and bring them toward their bodies while the kinematics of their wrist movement was measured. The results showed that the time to peak velocity increased for bringing pleasant stimuli towards the body compared to unpleasant and neutral ones, suggesting higher easiness in undertaking the task with pleasant stimuli. Furthermore, bringing unpleasant stimuli towards the body increased movement time in comparison with both pleasant and neutral ones while the time to peak velocity for unpleasant stimuli was the same as for that of neutral stimuli. There was no change in the trajectory length among emotional categories. We conclude that during the “reach-to-grasp” and “bring-to-the-body” movements, the valence of the stimuli affects the temporal but not the spatial kinematic features of motion. To the best of our knowledge, we show for the first time that the kinematic features of a goal-directed action are tuned by the emotional valence of the stimuli. PMID:27364868

  13. Motor planning of goal-directed action is tuned by the emotional valence of the stimulus: a kinematic study.

    PubMed

    Esteves, P O; Oliveira, L A S; Nogueira-Campos, A A; Saunier, G; Pozzo, T; Oliveira, J M; Rodrigues, E C; Volchan, E; Vargas, C D

    2016-07-01

    The basic underpinnings of homeostatic behavior include interacting with positive items and avoiding negative ones. As the planning aspects of goal-directed actions can be inferred from their movement features, we investigated the kinematics of interacting with emotion-laden stimuli. Participants were instructed to grasp emotion-laden stimuli and bring them toward their bodies while the kinematics of their wrist movement was measured. The results showed that the time to peak velocity increased for bringing pleasant stimuli towards the body compared to unpleasant and neutral ones, suggesting higher easiness in undertaking the task with pleasant stimuli. Furthermore, bringing unpleasant stimuli towards the body increased movement time in comparison with both pleasant and neutral ones while the time to peak velocity for unpleasant stimuli was the same as for that of neutral stimuli. There was no change in the trajectory length among emotional categories. We conclude that during the "reach-to-grasp" and "bring-to-the-body" movements, the valence of the stimuli affects the temporal but not the spatial kinematic features of motion. To the best of our knowledge, we show for the first time that the kinematic features of a goal-directed action are tuned by the emotional valence of the stimuli.

  14. The antinociceptive action of etorphine in the dorsal horn is due to a direct spinal action and not to activation of descending inhibition.

    PubMed Central

    Clark, S. L.; Ryall, R. W.

    1983-01-01

    1--Etorphine, microinjected into the brainstem or administered intravenously, inhibited the firing of dorsal horn neurones to noxious heat in spinal or non-spinal anaesthetized cats and in decerebrate, non-anaesthetized cats with intact spinal cords. 2--Small doses of etorphine sometimes caused facilitation, especially when the cord was intact, but this was invariably followed by inhibition at higher doses. 3--The ED50 for inhibition (mean 3.9 micrograms/kg) after microinjection into nucleus raphe magnus, nucleus reticularis magnocellularis or the lateral tegmental field was similar at all sites in anaesthetized, non-spinal cats. 4--The ED50 for microinjection was not increased by spinal transection in anaesthetized cats (mean ED50, 2.6 micrograms/kg) and was similar to the ED50 in decerebrate, non-anaesthetized cats. 5--Intravenous administration was 2 to 3 times more effective than microinjection and the time course of inhibition was faster after intravenous administration than after microinjection. 6--It is concluded that etorphine inhibits dorsal horn neurones after microinjection or intravenous administration by a direct action on the spinal cord and not by activating a descending inhibition. After microinjection it rapidly enters the general circulation and subsequently distributes into the spinal cord. 7--It is also concluded that naloxone readily gains entry to the circulation from the brain because microinjection antagonized the effects of systemic etorphine on dorsal horn neurones in spinal cats. PMID:6338986

  15. The molecular basis of the antiplatelet action of ajoene: direct interaction with the fibrinogen receptor.

    PubMed

    Apitz-Castro, R; Ledezma, E; Escalante, J; Jain, M K

    1986-11-26

    Ajoene, the major antiplatelet compound derived from garlic inhibits the fibrinogen-supported aggregation of washed human platelets (ID50 = 13 microM) and, inhibits binding of 125I-fibrinogen to ADP-stimulated platelets (ID50 = 0.8 microM). In both cases, the inhibition is of the mixed non-competitive type. Furthermore, fibrinogen-induced aggregation of chymotrypsin-treated platelets is also inhibited by ajoene in a dose-dependent manner (ID50 = 2.3 microM). Other membrane receptors such as ADP or epinephrine receptors are not affected by ajoene. Ajoene strongly quenches the intrinsic fluorescence emission of purified glycoproteins IIb-IIIa (ID50 = 10 microM). These results indicate that the antiaggregatory effect of ajoene is causally related to its direct interaction with the putative fibrinogen receptor.

  16. Thrombostatin FM compounds: direct thrombin inhibitors - mechanism of action in vitro and in vivo

    SciTech Connect

    Nieman, M T; Burke, F; Warnock, M; Zhou, Y; Sweigart, J; Chen, A; Ricketts, D; Lucchesi, B R; Chen, Z; Cera, E Di; Hilfinger, J; Kim, J S; Mosberg, H I; Schmaier, A H

    2008-04-29

    Novel pentapeptides called Thrombostatin FM compounds consisting mostly of D-isomers and unusual amino acids were prepared based upon the stable angiotensin converting enzyme breakdown product of bradykinin - RPPGF. These peptides are direct thrombin inhibitors prolonging the thrombin clotting time, activated partial thromboplastin time, and prothrombin time at ≥0.78, 1.6, and 1.6 μm, respectively. They competitively inhibit α-thrombin-induced cleavage of a chromogenic substrate at 4.4--8.2 μm. They do not significantly inhibit plasma kallikrein, factor (F) XIIa, FXIa, FIXa, FVIIa-TF, FXa, plasmin or cathepsin G. One form, FM19 [rOicPaF(p-Me)], blocks α-thrombin-induced calcium flux in fibroblasts with an IC50 of 6.9 ± 1.2 μm. FM19 achieved 100% inhibition of threshold α- or γ-thrombin-induced platelet aggregation at 8.4 ± 4.7 μm and 16 ± 4 μm, respectively. The crystal structure of thrombin in complex with FM19 shows that the N-terminal D-Arg retrobinds into the S1 pocket, its second residue Oic interacts with His-57, Tyr-60a and Trp-60d, and its C-terminal p-methyl Phe engages thrombin's aryl binding site composed of Ile-174, Trp-215, and Leu-99. When administered intraperitoneal, intraduodenal, or orally to mice, FM19 prolongs thrombin clotting times and delays carotid artery thrombosis. FM19, a low affinity reversible direct thrombin inhibitor, might be useful as an add-on agent to address an unmet need in platelet inhibition in acute coronary syndromes in diabetics and others who with all current antiplatelet therapy still have reactive platelets.

  17. Thrombostatin FM compounds: direct thrombin inhibitors – mechanism of action in vitro and in vivo

    PubMed Central

    Nieman, M. T.; Burke, F.; Warnock, M.; Zhou, Y.; Sweigart, J.; Chen, A.; Ricketts, D.; Lucchesi, B. R.; Chen, Z.; Di Cera, E.; Hilfinger, J.; Kim, J. S.; Mosberg, H. I.; Schmaier, A. H.

    2009-01-01

    Summary Background Novel pentapeptides called Thrombostatin FM compounds consisting mostly of D-isomers and unusual amino acids were prepared based upon the stable angiotensin converting enzyme breakdown product of bradykinin – RPPGF. Methods and Results These peptides are direct thrombin inhibitors prolonging the thrombin clotting time, activated partial thromboplastin time, and prothrombin time at ≥0.78, 1.6, and 1.6 µm, respectively. They competitively inhibit α-thrombin-induced cleavage of a chromogenic substrate at 4.4–8.2 µm. They do not significantly inhibit plasma kallikrein, factor (F) XIIa, FXIa, FIXa, FVIIa-TF, FXa, plasmin or cathepsin G. One form, FM19 [rOicPaF(p-Me)], blocks α-thrombin-induced calcium flux in fibroblasts with an IC50 of 6.9 ± 1.2 µm. FM19 achieved 100% inhibition of threshold α- or γ-thrombin-induced platelet aggregation at 8.4 ± 4.7 µm and 16 ± 4 µm, respectively. The crystal structure of thrombin in complex with FM19 shows that the N-terminal D-Arg retrobinds into the S1 pocket, its second residue Oic interacts with His-57, Tyr-60a and Trp-60d, and its C-terminal p-methyl Phe engages thrombin_s aryl binding site composed of Ile-174, Trp-215, and Leu-99. When administered intraperitoneal, intraduodenal, or orally to mice, FM19 prolongs thrombin clotting times and delays carotid artery thrombosis. Conclusion FM19, a low affinity reversible direct thrombin inhibitor, might be useful as an add-on agent to address an unmet need in platelet inhibition in acute coronary syndromes in diabetics and others who with all current antiplatelet therapy still have reactive platelets. PMID:18315550

  18. 24 CFR 1710.18 - No action letter.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION General Requirements § 1710.18 No action letter. (a) If the sale of lots is subject to the registration requirements of the Act but the circumstances of the sale are such that no affirmative action to enforce the registration requirements is...

  19. 24 CFR 1710.18 - No action letter.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION General Requirements § 1710.18 No action letter. (a) If the sale of lots is subject to the registration requirements of the Act but the circumstances of the sale are such that no affirmative action to enforce the registration requirements is...

  20. Report on Action Research: An Analysis of the Effects of a Six Step Approach to Direct Vocabulary Instruction on Student Achievement at the Middle School Level

    ERIC Educational Resources Information Center

    Haystead, Mark W.

    2009-01-01

    This report describes the findings of an analysis of a series of action research projects conducted by Goshen Community Schools at the middle school level. During the 2008-2009 school year, six teachers at Goshen Middle School participated in independent action research studies regarding the extent to which a six step approach to direct vocabulary…

  1. 20 CFR 10.709 - What happens if a beneficiary directed by OWCP or SOL to take action against a third party does...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... OWCP or SOL to take action against a third party does not believe that a claim can be successfully... beneficiary directed by OWCP or SOL to take action against a third party does not believe that a claim can be... should request that OWCP or SOL release him or her from the obligation to proceed. This request should...

  2. 20 CFR 10.709 - What happens if a beneficiary directed by OWCP or SOL to take action against a third party does...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... OWCP or SOL to take action against a third party does not believe that a claim can be successfully... beneficiary directed by OWCP or SOL to take action against a third party does not believe that a claim can be... should request that OWCP or SOL release him or her from the obligation to proceed. This request should...

  3. Sildenafil increases serum testosterone levels by a direct action on the testes.

    PubMed

    Spitzer, M; Bhasin, S; Travison, T G; Davda, M N; Stroh, H; Basaria, S

    2013-11-01

    Phosphodiesterase-5-inhibitors, such as sildenafil, increase intracavernosal cyclic guanosine monophosphate levels, which results in corporal smooth muscle relaxation and penile erection. Here, we determined the effects of sildenafil administration on the hypothalamic-pituitary-gonadal axis in men with erectile dysfunction and low testosterone levels. The Testosterone and Erectile Dysfunction trial (ClinicalTrials.gov # NCT00512707) initially administered an optimized dose of sildenafil to 140 men, aged 40-70 years with erectile dysfunction, low serum total testosterone (<11.4 nmol/L; 330 ng/dL) and/or free testosterone (<173 pmol/L; 50 pg/mL) over 3-7 weeks. Sex steroids and gonadotropins were measured at baseline and after sildenafil optimization in a longitudinal study without a separate control group. Serum testosterone, dihydrotestosterone (DHT) and oestrogens were measured using liquid chromatography-tandem mass spectrometry. Administration of an optimized dose of sildenafil was associated with mean increases of 3.6 nmol/L (103 ng/dL; p < 0.001) and 110 pmol/L (31.7 pg/mL; p < 0.001) in total and free testosterone levels respectively. This was accompanied by parallel increases in serum DHT (0.17 nmol/L; 4.9 ng/dL; p < 0.001) and oestradiol (14 pmol/L; 3.7 pg/mL; p < 0.001) and significant suppression of luteinizing hormone (change -1.3 units/L; p = 0.003) levels, suggesting a direct effect at the testicular level. Androstenedione and oestrone increased by 1.3 nmol/L (38 ng/dL; p = 0.011) and 10.7 pmol/L (2.9 pg/mL; p = 0.012), respectively, supporting a possible effect of sildenafil on adrenal steroidogenesis. In conclusion, sildenafil administration was associated with increased testosterone levels likely ascribable to a direct effect on the testis.

  4. Direct vascular actions of quercetin in aorta from renal hypertensive rats

    PubMed Central

    Choi, Seok; Ryu, Kwon Ho; Park, Sang Hag; Jun, Jae Yeoul; Shin, Byung Chul; Chung, Jong Hoon; Yeum, Cheol Ho

    2016-01-01

    Background Chronic treatment with the dietary flavonoid quercetin is known to lower blood pressure and restore endothelial dysfunction in animal models of hypertension. This study investigated the direct effects of quercetin on vascular response in chronic 2-kidney, 1-clip (2K1C) renal hypertensive rats. The effects of antioxidant vitamin ascorbic acid on the vasoreactivity were also examined. Methods 2K1C renal hypertension was induced by clipping the left renal artery; age-matched rats that received sham treatment served as controls. Thoracic aortae were mounted in tissue baths for the measurement of isometric tension. Results Relaxant responses to acetylcholine were significantly attenuated in 2K1C rats in comparison with sham rats. Quercetin or ascorbic acid augmented acetylcholine-induced relaxation in 2K1C rats, whereas no significant differences were noted in sham rats. The relaxation response to sodium nitroprusside was comparable between 2K1C and sham rats, and sodium nitroprusside–induced relaxation was not altered by quercetin or ascorbic acid in either group. The contractile response to phenylephrine was significantly enhanced in 2K1C rats compared with sham rats. Phenylephrine-induced contraction was inhibited by pretreatment with quercetin or ascorbic acid in 2K1C rats, whereas neither chemical affected responses in sham rats. Nw-nitro-L-arginine methyl ester markedly augmented the contractile response to phenylephrine in sham rats, whereas no significant differences were observed in 2K1C rats. Quercetin or ascorbic acid did not affect phenylephrine-induced contraction in the presence of Nw-nitro-L-arginine methyl ester in either 2K1C or sham rats. Conclusion Acute exposure to quercetin appears to improve endothelium-dependent relaxation and inhibit the contractile response, similar to the effect of ascorbic acid in 2K1C hypertension. These results partially explain the vascular beneficial effects of quercetin in renal hypertension. PMID:27069853

  5. Direct estradiol and diethylstilbestrol actions on early- vs. late-stage prostate cancer cells

    PubMed Central

    Koong, Luke Y.; Watson, Cheryl S.

    2014-01-01

    BACKGROUND: Diethylstilbestrol (DES) and other pharmaceutical estrogens have been used at ≥μM concentrations to treat advanced prostate tumors, with successes primarily attributed to indirect hypothalamic-pituitary-testicular axis control mechanisms. However, estrogens also directly affect tumor cells, though the mechanisms involved are not well understood. METHODS: LAPC-4 (androgen-dependent) and PC-3 (androgen-independent) cell viability was measured after estradiol (E2) or DES treatment across wide concentration ranges. We then examined multiple rapid signaling mechanisms at 0.1 nM E2 and 1μM DES optima including levels of: activation (phosphorylation) for mitogen-activated protein kinases, cell-cycle proteins, and caspase 3, necroptosis, and reactive oxygen species (ROS). RESULTS: LAPC-4 cells were more responsive than PC-3 cells. Robust and sustained extracellular-regulated kinase activation with E2, but not DES, correlated with ROS generation and cell death. c-Jun N-terminal kinase was only activated in E2-treated PC-3 cells and was not correlated with caspase 3-mediated apoptosis; necroptosis was not involved. The cell-cycle inhibitor protein p16INK4A was phosphorylated in both cell lines by both E2 and DES, but to differing extents. In both cell types, both estrogens activated p38 kinase, which subsequently phosphorylated cyclin D1, tagging it for degradation, except in DES-treated PC-3 cells. CONCLUSIONS: Cyclin D1 status correlated most closely with disrupted cell cycling as a cause of reduced cell numbers, though other mechanisms also contributed. As low as 0.1 nM E2 effectively elicited these mechanisms, and its use could dramatically improve outcomes for both early- and late-stage prostate cancer patients, while avoiding the side effects of high-dose DES treatment. PMID:25213831

  6. Affirmative Action: A Course for the Future. Affirmative Action Task Force for the Study "New Directions: African Americans in a Diversifying Nation."

    ERIC Educational Resources Information Center

    Joint Center for Political and Economic Studies, Washington, DC.

    A primary social dilemma today is that current strategies have led to the perception that affirmative action favors some population groups at the expense of others, that in a sense it uses one form of discrimination to combat another. It is essential to reconsider affirmative action strategies to implement those that are most appropriate for today…

  7. Contribution of direct actions of the oxime HI-6 in reversing soman-induced muscle weakness in the rat diaphragm.

    PubMed

    Adler, M; Maxwell, D M; Filbert, M G; Deshpande, S S

    1994-01-01

    The actions of the bispyridinium oxime HI-6 ([[[(4-aminocarbonyl)pyridino]-methoxy]methyl]-2- [(hydroxyimino)methyl]-pyridinium dichloride) were investigated in vitro on rat phrenic nerve-hemidiaphragm preparations. Isometric twitch and tetanic tensions were elicited at 37 degrees C with supramaximal nerve stimulation at frequencies of 20 and 50 Hz. To approximate normal respiration patterns, trials consisting of 30 successive 0.55 s trains were alternated with 1.25 s rest periods. Under control conditions, the above stimulation pattern generated tensions that were well maintained at both frequencies. In contrast, a marked depression of muscle tension was observed in diaphragms removed from rats administered 339 micrograms/kg soman (3 LD50) and tested in vitro. Addition of HI-6, 4 h after soman exposure, led to a nearly complete recovery of muscle tension at 20 Hz. At 50 Hz, muscle tensions still declined especially when trains were elicited at 1.25 and 3 s intervals. The recovery by HI-6 observed in this study appears to be mediated by mechanisms unrelated to acetylcholinesterase reactivation since no increase of enzymatic activity was detected and the effect was reversed by a brief washout in oxime-free physiological solution. The results suggest that the direct action of HI-6 may play a role in restoring soman-induced diaphragmatic failure but this effect would be significant primarily under low use conditions. PMID:8157086

  8. The Allocation of Attention to Learning of Goal-Directed Actions: A Cognitive Neuroscience Framework Focusing on the Basal Ganglia

    PubMed Central

    Franz, E. A.

    2012-01-01

    The present paper builds on the idea that attention is largely in service of our actions. A framework and model which captures the allocation of attention for learning of goal-directed actions is proposed and developed. This framework highlights an evolutionary model based on the notion that rudimentary functions of the basal ganglia have become embedded into increasingly higher levels of networks which all contribute to adaptive learning. Supporting the proposed model, background literature is presented alongside key evidence based on experimental studies in the so-called “split-brain” (surgically divided cerebral hemispheres), and selected evidence from related areas of research. Although overlap with other existing findings and models is acknowledged, the proposed framework is an original synthesis of cognitive experimental findings with supporting evidence of a neural system and a carefully formulated model of attention. It is the hope that this new synthesis will be informative in fields of cognition and other fields of brain sciences and will lead to new avenues for experimentation across domains. PMID:23267335

  9. A comparison of the other-directed stigmatization produced by legal and illegal forms of affirmative action.

    PubMed

    Evans, David C

    2003-02-01

    Recent studies have begun to show that the stigma of incompetence sometimes directed toward the beneficiaries of affirmative action may be significantly reduced as the preferences granted to women and minorities become more moderate. The author examined whether the stigmatization of African Americans would differ under hiring policies that represented legal and illegal levels of racial preference according to federal regulations. Participants were 178 students and 161 corporate employees who rated fictitious Black and White target employees working under (a) an illegal policy of selection of unequal candidates, (b) a legal policy of selection of comparable candidates, or (c) equal opportunity. Participants rated Black targets' achievement-related traits lower than White targets only under the illegal policy. Under the legal policy, no such stigmatization was observed. Additional dependent measures and theoretical implications were explored. PMID:12675400

  10. A Sales Representative: One Marketing Technique.

    ERIC Educational Resources Information Center

    Moore, George R.

    In 1985, in response to a sharp decline in student enrollment in vocational programs, especially in forestry and drafting technologies, Chemeketa Community College (CCC) (Oregon) adopted a carefully targeted marketing technique involving the use of a sales representative to approach prospective students directly. A temporary part-time position of…

  11. 21 CFR 1314.110 - Reports for mail-order sales.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Reports for mail-order sales. 1314.110 Section... LISTED CHEMICAL PRODUCTS Mail-Order Sales § 1314.110 Reports for mail-order sales. (a) Each regulated... Administration, submit the report in electronic form, either via computer disk or direct electronic...

  12. Effects of Targeted Sales Messages on Subscription Sales and Retention.

    ERIC Educational Resources Information Center

    Gamst, Glenn; And Others

    1987-01-01

    Investigates the effects of targeted sales messages on newspaper subscription sales and retention by combining two large research projects--a demographic market segmentation scheme, and a readership-lifestyle survey. Proposes that the content of sales messages influences new subscriptions but does not affect retention. (MM)

  13. Making It in Computer Sales.

    ERIC Educational Resources Information Center

    Davidson, Robert L., III

    1987-01-01

    Discusses some of the possibilities for careers in computer sales. Describes some of the attributes of quality computer salespersons, as illustrated by interviews with two experts on computer sales. (TW)

  14. Computerized Point of Sale = Faster Service + Better Accountability.

    ERIC Educational Resources Information Center

    Pannell, Dorothy V.

    1991-01-01

    Describes selecting and installing a computerized point of sale for a district food service program; the equipment needed and preferred; and the training of trainers, managers, and cashiers. Also discusses the direct benefits and side benefits of the system. (MLF)

  15. 7 CFR 1955.147 - Sealed bid sales.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Law 103-354 will accept the bid or bids which are in the best financial interest of the Government... Director may authorize either another sealed bid or auction sale of direct negotiations with the...

  16. 7 CFR 1955.147 - Sealed bid sales.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Law 103-354 will accept the bid or bids which are in the best financial interest of the Government... Director may authorize either another sealed bid or auction sale of direct negotiations with the...

  17. 7 CFR 1955.147 - Sealed bid sales.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Law 103-354 will accept the bid or bids which are in the best financial interest of the Government... Director may authorize either another sealed bid or auction sale of direct negotiations with the...

  18. 7 CFR 1955.147 - Sealed bid sales.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Law 103-354 will accept the bid or bids which are in the best financial interest of the Government... Director may authorize either another sealed bid or auction sale of direct negotiations with the...

  19. 7 CFR 1955.147 - Sealed bid sales.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Law 103-354 will accept the bid or bids which are in the best financial interest of the Government... Director may authorize either another sealed bid or auction sale of direct negotiations with the...

  20. From the 1996 groundwater action programme to the 2006 groundwater directive--what have we done, what have we learnt, what is the way ahead?

    PubMed

    Quevauviller, Philippe

    2008-04-01

    The need for action to avoid long term deterioration of fresh water quantity and quality was recognised by the Ministerial Seminar on groundwater held at The Hague in November 1991, which underlined the need to establish a programme of actions to be implemented by the year 2000 at national and Community level, aiming at sustainable management and protection of water resources. These discussions resulted in a communication from the European Commission in 1996 about a "Groundwater Action Programme" (GWAP). In parallel, a wide consultation had started on the need to streamline EU water policies, which led to the adoption of the Water Framework Directive in December 2000, later complemented by a "daughter" groundwater directive adopted in December 2006. This paper recalls the orientations of the GWAP and studies whether and how recommended actions have been tackled by the actual EU regulatory framework.

  1. Setting the Direction. Partnerships in Action: First Nations, Metis and Inuit Learning Access and Success. A Learning Alberta

    ERIC Educational Resources Information Center

    Alberta Advanced Education, 2006

    2006-01-01

    The Aboriginal Learning Subcommittee looked specifically at developing recommendations that address First Nations, Metis and Inuit learning needs and supports. The Subcommittee proposes policy actions and recommends that all stakeholders work together to implement these actions. The first recommendation for action is to build on partnerships to…

  2. Wildlife for sale.

    PubMed

    Martin, E; Redford, T

    2000-02-01

    Myanmar, famous for the smuggling of opium and gemstones, is losing much of its wildlife to illegal traders. In 1998, a survey of goods for sale in two border towns showed a thriving trade in body parts from some of the world's most endangered species.

  3. Gun Sales. Firearm Facts.

    ERIC Educational Resources Information Center

    Duker, Laurie, Ed.

    Minimal federal regulations on firearm sales have facilitated the proliferation of guns, gun owners, and gun dealers in the United States. This fact sheet offers data on the growing number of firearm dealers, the relative ease of obtaining and keeping a license to sell guns from the Federal Bureau of Alcohol, Tobacco, and Firearms, the lack of…

  4. Ariad suspends ponatinib sales.

    PubMed

    2014-01-01

    Because of concerns about serious cardiovascular side effects, the U.S. Food and Drug Administration asked Ariad Pharmaceuticals to temporarily suspend sales and marketing of ponatinib to treat chronic myeloid leukemia in patients resistant to first-line therapy. PMID:24402926

  5. Wildlife for sale.

    PubMed

    Martin, E; Redford, T

    2000-02-01

    Myanmar, famous for the smuggling of opium and gemstones, is losing much of its wildlife to illegal traders. In 1998, a survey of goods for sale in two border towns showed a thriving trade in body parts from some of the world's most endangered species. PMID:11190214

  6. Investigation of gender differences in the cardiovascular actions of direct and indirect sympathomimetic stimulants including cathinone in the anaesthetized rat.

    PubMed

    Alsufyani, H A; Docherty, J R

    2016-01-01

    We have studied gender differences in the direct and indirect sympathomimetic cardiovascular effects of the stimulant cathinone (from Khat) (and for comparison methylenedioxymethamphetamine [MDMA]) and the archetypal indirect sympathomimetic agent tyramine, employing male and female Wistar rats. Animals were sympathectomized by treatment with 6-hydroxydopamine or treated with vehicle. In male and female vehicle-treated pentobarbitone-anaesthetized rats, all three agonists (0.001-1 mg/kg) produced significant tachycardia, tyramine produced large pressor, and in high doses small depressor responses, MDMA produced small pressor responses, and cathinone produced only minor pressor effects. In sympathectomized rats, pressor responses, even those to tyramine, were virtually abolished, and depressor responses to tyramine were abolished. In vehicle-treated rats, the tachycardia to tyramine, but not the tachycardia to cathinone or MDMA, was significantly greater in male than female rats. This may suggest that the mechanism of the tachycardia to tyramine differs from those of the stimulants cathinone and MDMA. Following sympathectomy, there were no differences between male and female rats in the tachycardia to any agent. Hence, there were gender differences in the tachycardia response for tyramine, but no gender differences in the cardiovascular responses to the widely used recreational stimulants cathinone and MDMA. Cardiac stimulant actions of cathinone and MDMA were similar in male and female rats. PMID:27534387

  7. Reducing the illegal sale of cigarettes to minors.

    PubMed

    Altman, D G; Foster, V; Rasenick-Douss, L; Tye, J B

    1989-01-01

    This study reports on an effort to stop the illegal sale of cigarettes to minors. In Santa Clara County, Calif, 412 stores and 30 vending machines were visited by 18 minors aged 14 through 16 years with the intent to purchase cigarettes; they were successful at 74% of the stores and 100% of the vending machines. After an aggressive six-month campaign using communitywide media, direct merchant education, contact with the chief executive officers of chain stores and franchise operations owned by major companies, and grassroots work with community organizations, the percentage of stores with illegal over-the-counter sale of cigarettes to minors was reduced to 39%. Sales from vending machines were not reduced. While much remains to be accomplished in stopping the illegal sale of tobacco to minors, data from this study illustrate that a well-designed community and merchant education campaign can significantly reduce such sales. PMID:2908999

  8. Sales Education Efficacy: Examining the Relationship between Sales Education and Sales Success

    ERIC Educational Resources Information Center

    Bolander, William; Bonney, Leff; Satornino, Cinthia

    2014-01-01

    Sales education is on the rise and for good reason. Statistics say that sales jobs will continue to grow at a rapid rate over the next few years. Many universities are preparing their students to start their careers in the professional selling function through the inclusion of sales education in their business curriculum. Yet little research…

  9. Is automatic imitation based on goal coding or movement coding? A comparison of goal-directed and goal-less actions.

    PubMed

    Chiavarino, Claudia; Bugiani, Stefano; Grandi, Elisa; Colle, Livia

    2013-01-01

    A key issue for research on automatic imitation is whether it occurs primarily at the level of movements, that is, by automatically activating a representation of the movement/effector involved in the execution of the observed action, or at the level of goals, that is, by triggering a representation of the action goal, irrespective of how the motor act is physically instantiated. The present study presents two experiments aimed at investigating the contribution of movement coding and goal coding to automatic imitation, by assessing participants' performance in a spatial compatibility task where the observed stimuli were goal-directed and goal-less actions, which have been demonstrated to elicit, respectively, goal and movement coding. We found a significant automatic imitation effect both when the stimuli were goal-less actions and when they were actions directed toward a goal. However, the effect was stronger for the goal-less actions, even after controlling for saliency effects. These results suggest that goal coding contributes to automatic imitation, but to a lesser degree compared to movement coding. The implications of these results for theory and research on automatic imitation are discussed. PMID:23422654

  10. Is automatic imitation based on goal coding or movement coding? A comparison of goal-directed and goal-less actions.

    PubMed

    Chiavarino, Claudia; Bugiani, Stefano; Grandi, Elisa; Colle, Livia

    2013-01-01

    A key issue for research on automatic imitation is whether it occurs primarily at the level of movements, that is, by automatically activating a representation of the movement/effector involved in the execution of the observed action, or at the level of goals, that is, by triggering a representation of the action goal, irrespective of how the motor act is physically instantiated. The present study presents two experiments aimed at investigating the contribution of movement coding and goal coding to automatic imitation, by assessing participants' performance in a spatial compatibility task where the observed stimuli were goal-directed and goal-less actions, which have been demonstrated to elicit, respectively, goal and movement coding. We found a significant automatic imitation effect both when the stimuli were goal-less actions and when they were actions directed toward a goal. However, the effect was stronger for the goal-less actions, even after controlling for saliency effects. These results suggest that goal coding contributes to automatic imitation, but to a lesser degree compared to movement coding. The implications of these results for theory and research on automatic imitation are discussed.

  11. Hospitals for sale.

    PubMed

    Costello, Michael M; West, Daniel J; Ramirez, Bernardo

    2011-01-01

    The pace of hospital merger and acquisition activity reflects the economic theory of supply and demand: Publicly traded hospital companies, private equity funds, and large nonprofit hospital systems are investing capital to purchase and operate freestanding community hospitals at a time when many of those hospitals find themselves short of capital reserves and certain forms of management expertise. But the sale of those community hospitals also raises questions about the impact of absentee ownership on the communities which those hospitals serve.

  12. The vasorelaxing action of rutaecarpine: direct paradoxical effects on intracellular calcium concentration of vascular smooth muscle and endothelial cells.

    PubMed

    Wang, G J; Shan, J; Pang, P K; Yang, M C; Chou, C J; Chen, C F

    1996-03-01

    We have examined both the hypotensive effect and the mechanism of intracellular Ca++ regulation, underlying rutaecarpine (Rut)-induced vasodilatation. An i.v. bolus injection of Rut in anesthetized Sprague-Dawley rats produced a dose-dependent hypotensive effect. In isolated rat aorta rings, Rut (0.1-3 mu M) inhibited the phasic and tonic responses of norepinephrine- and phyenylephrine-induced contractions, respectively, mainly through an endothelium-dependent mechanism. However, the vasorelaxing effect of Rut (3 microM) persisted in denuded aorta, although to a much less extent than in intact tissue. As determined by the fura-2/AM (1-[2-(5-carboxyoxazol-2-yl)-6-aminobenzofuran-5-oxy]-2-(2'- amino-5'-methylphenoxy)-ethane-N,N,N,N-tetraacetic acid pentaacetoxymethyl ester) method, Rut (10 microM), in the presence of extracellular Ca++, suppressed the KCI-induced increment in the intracellular Ca++ concentration ([Ca++]i) of cultured vascular smooth muscle cells (VSMC). Rut (10 microM) also attenuated the norepinephrine-induced peak rise of [Ca++]i in VSMC placed in Ca++-free solution. On the other hand, Rut (1 and 10 microM) increased the level of [Ca++]i of cultured endothelial cells (EC) in the presence of extracellular Ca++. In conclusion, Rut acts on both VSMC and EC directly. In VSMC, it reduces [Ca++]i through the inhibition of Ca++ influx and Ca++ release from intracellular stores. In EC, Rut augments EC [Ca++]i by increasing Ca++ influx, possibly leading to nitric oxide release. The paradoxical regulation of Ca++ in both VSMC and EC acts simultaneously to cause vasorelaxation which could account, at least in part, for the hypotensive action. This is a most significant and a unique feature of this study. PMID:8786530

  13. A Comparison of Beliefs and Disbeliefs and Reference Category Characteristics as Directive Factors of Social Action in Five Cultures.

    ERIC Educational Resources Information Center

    Reeder, William W.; And Others

    In order to illustrate the cross-culture applicability of Reeder's Theory of Beliefs, Disbeliefs, and Social Action and its usefulness in predicting and explaining social actions, studies conducted in communities in India, Sudan, Lebanon, northeastern United States, and western United States are examined. Using this theory, beliefs and disbeliefs…

  14. Sales promotions and food consumption.

    PubMed

    Hawkes, Corinna

    2009-06-01

    Sales promotions are widely used to market food to adults, children, and youth. Yet, in contrast to advertising, practically no attention has been paid to their impacts on dietary behaviors, or to how they may be used more effectively to promote healthy eating. This review explores the available literature on the subject. The objective is to identify if and what literature exists, examine the nature of this literature, and analyze what can be learned from it about the effects of sales promotions on food consumption. The review finds that while sales promotions lead to significant sales increases over the short-term, this does not necessarily lead to changes in food-consumption patterns. Nevertheless, there is evidence from econometric modeling studies indicating that sales promotions can influence consumption patterns by influencing the purchasing choices of consumers and encouraging them to eat more. These effects depend on the characteristics of the food product, sales promotion, and consumer. The complexity of the effects means that sales promotions aiming to encourage consumption of nutritious foods need to be carefully designed. These conclusions are based on studies that use mainly sales data as a proxy for dietary intake. The nutrition (and economics) research communities should add to this existing body of research to provide evidence on the impact of sales promotions on dietary intake and related behaviors. This would help support the development of a sales promotion environment conducive to healthy eating. PMID:19519674

  15. 26 CFR 301.7505-1 - Sale of personal property acquired by the United States.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... to make deposits to secure the performance of their agreements. Any such deposit, but not more than... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Sale of personal property acquired by the... Actions by the United States § 301.7505-1 Sale of personal property acquired by the United States....

  16. 78 FR 19520 - Notice of Competitive Coal Lease Sale COC-74813, CO

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-01

    ... Bureau of Land Management Notice of Competitive Coal Lease Sale COC-74813, CO AGENCY: Bureau of Land Management, Interior. ACTION: Notice of Competitive Coal Lease Sale. SUMMARY: Notice is hereby given that certain Federal coal reserves (Red Wash Tracts 1 and 2) in Moffat and Rio Blanco Counties, Colorado,...

  17. 7 CFR 46.19 - Sales tickets.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Sales tickets. 46.19 Section 46.19 Agriculture... Receivers § 46.19 Sales tickets. Sales tickets shall bear printed serial numbers running consecutively and...-day period. The sales tickets shall be prepared and all the details of the sale shall be entered...

  18. 27 CFR 11.22 - Consignment sales.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Consignment sales. 11.22... OF THE TREASURY LIQUORS CONSIGNMENT SALES Unlawful Sales Arrangements § 11.22 Consignment sales. Consignment sales are arrangements wherein the trade buyer is under no obligation to pay for distilled...

  19. 29 CFR 779.327 - Wholesale sales.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Wholesale sales. 779.327 Section 779.327 Labor Regulations... Particular Industryâ § 779.327 Wholesale sales. A wholesale sale, of course, is not recognized as a retail sale. If an establishment derives more than 25 percent of its annual dollar volume from sales made...

  20. 29 CFR 779.327 - Wholesale sales.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Wholesale sales. 779.327 Section 779.327 Labor Regulations... Particular Industryâ § 779.327 Wholesale sales. A wholesale sale, of course, is not recognized as a retail sale. If an establishment derives more than 25 percent of its annual dollar volume from sales made...

  1. 27 CFR 11.22 - Consignment sales.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Consignment sales. 11.22... OF THE TREASURY ALCOHOL CONSIGNMENT SALES Unlawful Sales Arrangements § 11.22 Consignment sales. Consignment sales are arrangements wherein the trade buyer is under no obligation to pay for distilled...

  2. 32 CFR 644.544 - Negotiated sales.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 4 2012-07-01 2011-07-01 true Negotiated sales. 644.544 Section 644.544... ESTATE HANDBOOK Disposal Sale Procedure § 644.544 Negotiated sales. (a) To private parties. Negotiated sales to private parties are not viewed with favor. Generally, such negotiated sales will be...

  3. 7 CFR 46.19 - Sales tickets.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Sales tickets. 46.19 Section 46.19 Agriculture... Receivers § 46.19 Sales tickets. Sales tickets shall bear printed serial numbers running consecutively and...-day period. The sales tickets shall be prepared and all the details of the sale shall be entered...

  4. 29 CFR 779.327 - Wholesale sales.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Wholesale sales. 779.327 Section 779.327 Labor Regulations... Particular Industryâ § 779.327 Wholesale sales. A wholesale sale, of course, is not recognized as a retail sale. If an establishment derives more than 25 percent of its annual dollar volume from sales made...

  5. 7 CFR 46.19 - Sales tickets.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Sales tickets. 46.19 Section 46.19 Agriculture... Receivers § 46.19 Sales tickets. Sales tickets shall bear printed serial numbers running consecutively and...-day period. The sales tickets shall be prepared and all the details of the sale shall be entered...

  6. 29 CFR 779.327 - Wholesale sales.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Wholesale sales. 779.327 Section 779.327 Labor Regulations... Particular Industryâ § 779.327 Wholesale sales. A wholesale sale, of course, is not recognized as a retail sale. If an establishment derives more than 25 percent of its annual dollar volume from sales made...

  7. 32 CFR 644.544 - Negotiated sales.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 4 2013-07-01 2013-07-01 false Negotiated sales. 644.544 Section 644.544... ESTATE HANDBOOK Disposal Sale Procedure § 644.544 Negotiated sales. (a) To private parties. Negotiated sales to private parties are not viewed with favor. Generally, such negotiated sales will be...

  8. 27 CFR 11.22 - Consignment sales.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Consignment sales. 11.22... OF THE TREASURY LIQUORS CONSIGNMENT SALES Unlawful Sales Arrangements § 11.22 Consignment sales. Consignment sales are arrangements wherein the trade buyer is under no obligation to pay for distilled...

  9. 7 CFR 46.19 - Sales tickets.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Sales tickets. 46.19 Section 46.19 Agriculture... Receivers § 46.19 Sales tickets. Sales tickets shall bear printed serial numbers running consecutively and...-day period. The sales tickets shall be prepared and all the details of the sale shall be entered...

  10. 27 CFR 11.22 - Consignment sales.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Consignment sales. 11.22... OF THE TREASURY ALCOHOL CONSIGNMENT SALES Unlawful Sales Arrangements § 11.22 Consignment sales. Consignment sales are arrangements wherein the trade buyer is under no obligation to pay for distilled...

  11. 32 CFR 644.544 - Negotiated sales.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 4 2014-07-01 2013-07-01 true Negotiated sales. 644.544 Section 644.544... ESTATE HANDBOOK Disposal Sale Procedure § 644.544 Negotiated sales. (a) To private parties. Negotiated sales to private parties are not viewed with favor. Generally, such negotiated sales will be...

  12. 27 CFR 11.22 - Consignment sales.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Consignment sales. 11.22... OF THE TREASURY LIQUORS CONSIGNMENT SALES Unlawful Sales Arrangements § 11.22 Consignment sales. Consignment sales are arrangements wherein the trade buyer is under no obligation to pay for distilled...

  13. 7 CFR 46.19 - Sales tickets.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Sales tickets. 46.19 Section 46.19 Agriculture... Receivers § 46.19 Sales tickets. Sales tickets shall bear printed serial numbers running consecutively and...-day period. The sales tickets shall be prepared and all the details of the sale shall be entered...

  14. Fuel Oil and Kerosene Sales

    EIA Publications

    2015-01-01

    Provides information, illustrations and state-level statistical data on end-use sales of kerosene; No.1, No. 2, and No. 4 distillate fuel oil; and residual fuel oil. State-level kerosene sales include volumes for residential, commercial, industrial, farm, and all other uses. State-level distillate sales include volumes for residential, commercial, industrial, oil company, railroad, vessel bunkering, military, electric utility, farm, on-highway, off-highway construction, and other uses. State-level residual fuel sales include volumes for commercial, industrial, oil company, vessel bunkering, military, electric utility, and other uses.

  15. Satellites For Sale

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Astronaut Dale A. Gardner, having just completed the major portion of his second extravehicular activity (EVA) period in three days, holds up a 'For Sale' sign refering to the two satellites, Palapa B-2 and Westar 6 that they retrieved from orbit after their Payload Assist Modules (PAM) failed to fire. Astronaut Joseph P. Allen IV, who also participated in the two EVAs, is reflected in Gardner's helmet visor. A portion of each of two recovered satellites is in the lower right corner, with Westar 6 nearer Discovery's aft.

  16. Estimating sales and sales market share from sales rank data for consumer appliances

    NASA Astrophysics Data System (ADS)

    Touzani, Samir; Van Buskirk, Robert

    2016-06-01

    Our motivation in this work is to find an adequate probability distribution to fit sales volumes of different appliances. This distribution allows for the translation of sales rank into sales volume. This paper shows that the log-normal distribution and specifically the truncated version are well suited for this purpose. We demonstrate that using sales proxies derived from a calibrated truncated log-normal distribution function can be used to produce realistic estimates of market average product prices, and product attributes. We show that the market averages calculated with the sales proxies derived from the calibrated, truncated log-normal distribution provide better market average estimates than sales proxies estimated with simpler distribution functions.

  17. 78 FR 62588 - 36(b)(1) Arms Sales Notification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Office of the Secretary 36(b)(1) Arms Sales Notification AGENCY: Defense Security Cooperation Agency, Department of Defense. ACTION: Notice. SUMMARY: The Department of Defense is publishing the unclassified...

  18. 78 FR 62590 - 36(b)(1) Arms Sales Notification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Office of the Secretary 36(b)(1) Arms Sales Notification AGENCY: Department of Defense, Defense Security Cooperation Agency. ACTION: Notice. SUMMARY: The Department of Defense is publishing the unclassified text...

  19. 78 FR 62600 - 36(b)(1) Arms Sales Notification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Office of the Secretary 36(b)(1) Arms Sales Notification AGENCY: Defense Security Cooperation Agency, Department of Defense. ACTION: Notice. SUMMARY: The Department of Defense is publishing the unclassified...

  20. 78 FR 62592 - 36(b)(1) Arms Sales Notification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Office of the Secretary 36(b)(1) Arms Sales Notification AGENCY: Defense Security Cooperation Agency, Department of Defense. ACTION: Notice. SUMMARY: The Department of Defense is publishing the unclassified...

  1. 78 FR 15004 - 36(b)(1) Arms Sales Notification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Office of the Secretary 36(b)(1) Arms Sales Notification AGENCY: Defense Security Cooperation Agency, Department of Defense. ACTION: Notice. SUMMARY: The Department of Defense is publishing the unclassified...

  2. 78 FR 72066 - 36(b)(1) Arms Sales Notification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Office of the Secretary 36(b)(1) Arms Sales Notification AGENCY: Department of Defense, Defense Security Cooperation Agency. ACTION: Notice. SUMMARY: The Department of Defense is publishing the unclassified text...

  3. 75 FR 30787 - 36(b)(1) Arms Sales Notification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-02

    ... of the Secretary 36(b)(1) Arms Sales Notification AGENCY: Defense Security Cooperation Agency, DoD. ACTION: Notice. SUMMARY: The Department of Defense is publishing the unclassified text of a section 36(b... July 1996. FOR FURTHER INFORMATION CONTACT: Ms. B. English, DSCA/DBO/CFM, (703) 601-3740. The...

  4. 75 FR 51445 - 36(b)(1) Arms Sales Notification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-20

    ... of the Secretary 36(b)(1) Arms Sales Notification AGENCY: Defense Security Cooperation Agency, DoD. ACTION: Notice. SUMMARY: The Department of Defense is publishing the unclassified text of a section 36(b... July 1996. FOR FURTHER INFORMATION CONTACT: Ms. B. English, DSCA/DBO/CFM, (703) 601-3740....

  5. 75 FR 4785 - 36(b)(1) Arms Sales Notification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-29

    ... of the Secretary 36(b)(1) Arms Sales Notification AGENCY: Defense Security Cooperation Agency, DoD. ACTION: Notice. SUMMARY: The Department of Defense is publishing the unclassified text of a section 36(b... July 1996. FOR FURTHER INFORMATION CONTACT: Ms. B. English, DSCA/DBO/CFM, (703) 601-3740....

  6. 75 FR 48947 - 36(b)(1) Arms Sales Notification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-12

    ... of the Secretary 36(b)(1) Arms Sales Notification AGENCY: Defense Security Cooperation Agency, DoD. ACTION: Notice. SUMMARY: The Department of Defense is publishing the unclassified text of a section 36(b... July 1996. FOR FURTHER INFORMATION CONTACT: Ms. B. English, DSCA/DBO/CFM, (703) 601-3740....

  7. 76 FR 63323 - Notice of Competitive Coal Lease Sale, Montana

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ... Bureau of Land Management Notice of Competitive Coal Lease Sale, Montana AGENCY: Bureau of Land Management, Interior. ACTION: Notice. SUMMARY: Notice is hereby given that the coal reserves in the lands... by application (LBA) filed by Signal Peak Energy LLC. The Federal coal resource to be...

  8. 77 FR 31385 - Notice of Competitive Coal Lease Sale, Wyoming

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-25

    ... Bureau of Land Management Notice of Competitive Coal Lease Sale, Wyoming AGENCY: Bureau of Land Management, Interior. ACTION: Notice. SUMMARY: Notice is hereby given that certain coal resources in the North Porcupine Coal Tract described below in Campbell County, Wyoming, will be offered for...

  9. 77 FR 3790 - Notice of Competitive Coal Lease Sale, Wyoming

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-25

    ... Bureau of Land Management Notice of Competitive Coal Lease Sale, Wyoming AGENCY: Bureau of Land Management, Interior. ACTION: Notice. SUMMARY: Notice is hereby given that certain coal resources in the South Porcupine Coal Tract described below in Campbell County, Wyoming, will be offered for...

  10. 77 FR 22607 - Notice of Competitive Coal Lease Sale, Wyoming

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-16

    ... Bureau of Land Management Notice of Competitive Coal Lease Sale, Wyoming AGENCY: Bureau of Land Management, Interior. ACTION: Notice. SUMMARY: Notice is hereby given that certain coal resources in the South Porcupine Coal Tract described below in Campbell County, Wyoming, will be reoffered...

  11. 77 FR 2316 - Notice of Competitive Coal Lease Sale, Montana

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-17

    ... Bureau of Land Management Notice of Competitive Coal Lease Sale, Montana AGENCY: Bureau of Land Management, Interior. ACTION: Notice. SUMMARY: Notice is hereby given that the coal reserves in the lands... lease by application (LBA) filed by Signal Peak Energy LLC. The Federal coal resource to be...

  12. 76 FR 28063 - Notice of Competitive Coal Lease Sale, Wyoming

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ... Bureau of Land Management Notice of Competitive Coal Lease Sale, Wyoming AGENCY: Bureau of Land Management, Interior. ACTION: Notice. SUMMARY: Notice is hereby given that certain coal resources in the Belle Ayr North Coal Tract described below in Campbell County, Wyoming, will be offered for...

  13. 78 FR 26326 - 36(b)(1) Arms Sales Notification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-06

    ... Cooperation Agency. ACTION: Notice. SUMMARY: The Department of Defense is publishing the unclassified text of a section 36(b)(1) arms sales notification. This is published to fulfill the requirements of section.../DBO/CFM, (703) 601-3740. The following is a copy of a letter to the Speaker of the House...

  14. 78 FR 26328 - 36(b)(1) Arms Sales Notification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-06

    ..., Department of Defense. ACTION: Notice. SUMMARY: The Department of Defense is publishing the unclassified text of a section 36(b)(1) arms sales notification. This is published to fulfill the requirements of..., DSCA/DBO/CFM, (703) 601-3740. The following is a copy of a letter to the Speaker of the House...

  15. 78 FR 26324 - 36(b)(1) Arms Sales Notification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-06

    ..., Department of Defense. ACTION: Notice. SUMMARY: The Department of Defense is publishing the unclassified text of a section 36(b)(1) arms sales notification. This is published to fulfill the requirements of..., DSCA/DBO/CFM, (703) 601-3740. The following is a copy of a letter to the Speaker of the House...

  16. 78 FR 46579 - 36(b)(1) Arms Sales Notification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-01

    ... Cooperation Agency. ACTION: Notice. SUMMARY: The Department of Defense is publishing the unclassified text of a section 36(b)(1) arms sales notification. This is published to fulfill the requirements of section.../DBO/CFM, (703) 601-3740. The following is a copy of a letter to the Speaker of the House...

  17. 78 FR 78941 - 36(b)(1) Arms Sales Notification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-27

    ... Cooperation Agency. ACTION: Notice. SUMMARY: The Department of Defense is publishing the unclassified text of a section 36(b)(1) arms sales notification. This is published to fulfill the requirements of section.../DBO/CFM, (703) 601-3740. The following is a copy of a letter to the Speaker of the House...

  18. 75 FR 57106 - Public Notice for Sale of Airport Property at Houlton International Airport, Houlton, ME

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-17

    ... Federal Aviation Administration Public Notice for Sale of Airport Property at Houlton International Airport, Houlton, ME AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Request for public... (.73 acres) of Airport property. The property was acquired from the United States Government...

  19. Characterizing the associative content of brain structures involved in habitual and goal-directed actions in humans: a multivariate FMRI study.

    PubMed

    McNamee, Daniel; Liljeholm, Mimi; Zika, Ondrej; O'Doherty, John P

    2015-03-01

    While there is accumulating evidence for the existence of distinct neural systems supporting goal-directed and habitual action selection in the mammalian brain, much less is known about the nature of the information being processed in these different brain regions. Associative learning theory predicts that brain systems involved in habitual control, such as the dorsolateral striatum, should contain stimulus and response information only, but not outcome information, while regions involved in goal-directed action, such as ventromedial and dorsolateral prefrontal cortex and dorsomedial striatum, should be involved in processing information about outcomes as well as stimuli and responses. To test this prediction, human participants underwent fMRI while engaging in a binary choice task designed to enable the separate identification of these different representations with a multivariate classification analysis approach. Consistent with our predictions, the dorsolateral striatum contained information about responses but not outcomes at the time of an initial stimulus, while the regions implicated in goal-directed action selection contained information about both responses and outcomes. These findings suggest that differential contributions of these regions to habitual and goal-directed behavioral control may depend in part on basic differences in the type of information that these regions have access to at the time of decision making. PMID:25740507

  20. Using Magazine Ads to Teach Sales Writing.

    ERIC Educational Resources Information Center

    Halper, Cheryl A.

    1980-01-01

    Notes that using magazine advertisements to teach sales letter writing can help students understand sales techniques they see daily, but do not think much about. Presents a four-point strategy to help them put together effective sales letters. (FL)

  1. 48 CFR 245.7302 - Competitive sales.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Competitive sales. 245..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY Sale of Surplus Contractor Inventory 245.7302 Competitive sales....

  2. Electric sales and revenue: 1993

    SciTech Connect

    Not Available

    1995-01-01

    The Electric Sales and Revenue is prepared by the Survey Management Division, Office of Coal, Nuclear, Electric and Alternate Fuels; Energy Information Administration (EIA); US Department of Energy. This publication provides information about sales of electricity, its associated revenue, and the average revenue per kilowatthour sold to residential, commercial, industrial, and other consumers throughout the United States. The sales, revenue, and average revenue per kilowatthour data provided in the Electric Sales and Revenue are based on annual data reported by electric utilities for the calendar year ending December 31, 1993. Operating revenue includes energy charges, demand charges, consumer service charges, environmental surcharges, fuel adjustments, and other miscellaneous charges. The revenue does not include taxes, such as sales and excise taxes, that are assessed on the consumer and collected through the utility. Average revenue per kilowatthour is defined as the cost per unit of electricity sold and is calculated by dividing retail sales into the associated electric revenue. Because electric rates vary based on energy usage, average revenue per kilowatthour are affected by changes in the volume of sales. The sales of electricity, associated revenue, and average revenue per kilowatthour data provided in this report are presented at the national, Census division, State, and electric utility levels.

  3. Electric sales and revenue 1996

    SciTech Connect

    1997-12-01

    Information is provided on electricity sales, associated revenue, average revenue per kilowatthour sold, and number of consumers throughout the US. The data provided in the Electric Sales and Revenue are presented at the national, Census division, State, and electric utility levels. The information is based on annual data reported by electric utilities for the calendar year ending December 31, 1996. 16 figs., 20 tabs.

  4. Global Sales Training's Balancing Act

    ERIC Educational Resources Information Center

    Boehle, Sarah

    2010-01-01

    A one-size-fits-all global sales strategy that fails to take into account the cultural, regulatory, geographic, and economic differences that exist across borders is a blueprint for failure. For training organizations tasked with educating globally dispersed sales forces, the challenge is adapting to these differences while simultaneously…

  5. Is Earth F**ked? Dynamical Futility of Global Environmental Management and Possibilities for Sustainability via Direct Action Activism

    NASA Astrophysics Data System (ADS)

    wErnEr, B.

    2012-12-01

    Environmental challenges are dynamically generated within the dominant global culture principally by the mismatch between short-time-scale market and political forces driving resource extraction/use and longer-time-scale accommodations of the Earth system to these changes. Increasing resource demand is leading to the development of two-way, nonlinear interactions between human societies and environmental systems that are becoming global in extent, either through globalized markets and other institutions or through coupling to global environmental systems such as climate. These trends are further intensified by dissipation-reducing technological advances in transactions, communication and transport, which suppress emergence of longer-time-scale economic and political levels of description and facilitate long-distance connections, and by predictive environmental modeling, which strengthens human connections to a short-time-scale virtual Earth, and weakens connections to the longer time scales of the actual Earth. Environmental management seeks to steer fast scale economic and political interests of a coupled human-environmental system towards longer-time-scale consideration of benefits and costs by operating within the confines of the dominant culture using a linear, engineering-type connection to the system. Perhaps as evidenced by widespread inability to meaningfully address such global environmental challenges as climate change and soil degradation, nonlinear connections reduce the ability of managers to operate outside coupled human-environmental systems, decreasing their effectiveness in steering towards sustainable interactions and resulting in managers slaved to short-to-intermediate-term interests. In sum, the dynamics of the global coupled human-environmental system within the dominant culture precludes management for stable, sustainable pathways and promotes instability. Environmental direct action, resistance taken from outside the dominant culture, as in

  6. Tertiary Students and Social Development: An Area for Direct Action--Student Rural Service Activities in Malaysia.

    ERIC Educational Resources Information Center

    Kong, Kee Poo

    The study is a survey of the different kinds of voluntary rural service (service-learning) corps of students from the institutions of higher education in Malaysia. The history, organization, and activities of the service corps are examined, and this type of student social action is viewed with reference to the role of higher education in the…

  7. Class Action: Improving School Performance in the Developing World through Better Health and Nutrition. Directions in Development.

    ERIC Educational Resources Information Center

    Del Rosso, Joy Miller; Marek, Tonia

    This book summarizes how better nutrition and health for youths in developing nations will enhance: (1) school enrollment, attendance, and performance; (2) economic productivity; and (3) the health of future generations. By discussing the many low-cost and highly efficient actions that can improve school-age children's health and nutrition, this…

  8. IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor γ1

    PubMed Central

    Bendixen, Amy C.; Shevde, Nirupama K.; Dienger, Krista M.; Willson, Timothy M.; Funk, Colin D.; Pike, J. Wesley

    2001-01-01

    IL-4 is a pleiotropic immune cytokine secreted by activated TH2 cells that inhibits bone resorption both in vitro and in vivo. The cellular targets of IL-4 action as well as its intracellular mechanism of action remain to be determined. We show here that IL-4 inhibits receptor activator of NF-κB ligand-induced osteoclast differentiation through an action on osteoclast precursors that is independent of stromal cells. Interestingly, this inhibitory effect can be mimicked by both natural as well as synthetic peroxisome proliferator-activated receptor γ1 (PPARγ1) ligands and can be blocked by the irreversible PPARγ antagonist GW 9662. These findings suggest that the actions of IL-4 on osteoclast differentiation are mediated by PPARγ1, an interpretation strengthened by the observation that IL-4 can activate a PPARγ1-sensitive luciferase reporter gene in RAW264.7 cells. We also show that inhibitors of enzymes such as 12/15-lipoxygenase and the cyclooxygenases that produce known PPARγ1 ligands do not abrogate the IL-4 effect. These findings, together with the observation that bone marrow cells from 12/15-lipoxygenase-deficient mice retain sensitivity to IL-4, suggest that the cytokine may induce novel PPARγ1 ligands. Our results reveal that PPARγ1 plays an important role in the suppression of osteoclast formation by IL-4 and may explain the beneficial effects of the thiazolidinedione class of PPARγ1 ligands on bone loss in diabetic patients. PMID:11226258

  9. Goal-directed actions activate the face-sensitive posterior superior temporal sulcus and fusiform gyrus in the absence of human-like perceptual cues.

    PubMed

    Shultz, Sarah; McCarthy, Gregory

    2012-05-01

    The conditions under which we identify entities as animate agents and the neural mechanisms supporting this ability are central questions in social neuroscience. Prior studies have focused upon 2 perceptual cues for signaling animacy: 1) surface features representing body forms such as faces, torsos, and limbs and 2) motion cues associated with biological forms. Here, we consider a third cue--the goal-directedness of an action. Regions in the social brain network, such as the right posterior superior temporal sulcus (pSTS) and fusiform face area (FFA), are activated by human-like motion and body form perceptual cues signaling animacy. Here, we investigate whether these same brain regions are activated by goal-directed motion even when performed by entities that lack human-like perceptual cues. We observed an interaction effect whereby the presence of either human-like perceptual cues or goal-directed actions was sufficient to activate the right pSTS and FFA. Only stimuli that lacked human-like perceptual cues and goal-directed actions failed to activate the pSTS and FFA at the same level. PMID:21768227

  10. Weather, land satellite sale

    NASA Astrophysics Data System (ADS)

    Richman, Barbara T.

    President Ronald Reagan announced on March 8 plans to sell to private industry the nation's land and meteorological remote-sensing satellites, including the responsibility for any future ocean-observing systems. According to the plan, the private firm successful in its bid to buy the five satellites would sell back to the government the data received by the satellites. The Reagan administration says the sale will save money and will put activities appropriate for commercial ventures into the commercial sector. Response to the announcement from scientists and congressmen has been anything but dulcet; one senator, in fact, charges that the Commerce Department and the corporation most likely to purchase the satellites are engaged in a ‘sweetheart deal.’

  11. Electric sales and revenue, 1990

    SciTech Connect

    Not Available

    1992-02-21

    The Electric Sales and Revenue is prepared by the Survey Management Division, Office of Coal, Nuclear, Electric and Alternate Fuels; Energy Information Administration (EIA); US Department of Energy. This publication provides information about sales of electricity, its associated revenue, and the average revenue per kilowatthour sold to residential, commercial, industrial, and other consumers throughout the United States. Previous publications presented data on typical electric bills at specified consumption levels as well as sales, revenues, and average revenue. The sales, revenue, and average revenue per kilowatthour provided in the Electric Sales and Revenue are based on annual data reported by electric utilities for the calendar year ending December 31, 1990. The electric revenue reported by each electric utility includes the revenue billed for the amount of kilowatthours sold, revenue from income, unemployment and other State and local taxes, energy or demand charges, consumer services charges, environmental surcharges, franchise fees, fuel adjustments, and other miscellaneous charges. Average revenue per kilowatthour is defined as the cost per unit of electricity sold and is calculated by dividing retail sales into the associated electric revenue. The sales of electricity, associated revenue, and average revenue per kilowatthour provided in this report are presented at the national, Census division, State, and electric utility levels.

  12. The mechanical actions of muscles predict the direction of muscle activation during postural perturbations in the cat hindlimb.

    PubMed

    Honeycutt, Claire F; Nichols, T Richard

    2014-03-01

    Humans and cats respond to balance challenges, delivered via horizontal support surface perturbations, with directionally selective muscle recruitment and constrained ground reaction forces. It has been suggested that this postural strategy arises from an interaction of limb biomechanics and proprioceptive networks in the spinal cord. A critical experimental validation of this hypothesis is to test the prediction that the principal directions of muscular activation oppose the directions responding muscles exert their forces on the environment. Therefore, our objective was to quantify the endpoint forces of a diverse set of cat hindlimb muscles and compare them with the directionally sensitive muscle activation patterns generated in the intact and decerebrate cat. We hypothesized that muscles are activated based on their mechanical advantage. Our primary expectation was that the principal direction of muscle activation during postural perturbations will be directed oppositely (180°) from the muscle endpoint ground reaction force. We found that muscle activation during postural perturbations was indeed directed oppositely to the endpoint reaction forces of that muscle. These observations indicate that muscle recruitment during balance challenges is driven, at least in part, by limb architecture. This suggests that sensory sources that provide feedback about the mechanical environment of the limb are likely important to appropriate and effective responses during balance challenges. Finally, we extended the analysis to three dimensions and different stance widths, laying the groundwork for a more comprehensive study of postural regulation than was possible with measurements confined to the horizontal plane and a single stance configuration.

  13. Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity

    PubMed Central

    León, Silvia; Barroso, Alexia; Vázquez, María J.; García-Galiano, David; Manfredi-Lozano, María; Ruiz-Pino, Francisco; Heras, Violeta; Romero-Ruiz, Antonio; Roa, Juan; Schutz, Günther; Kirilov, Milen; Gaytan, Francisco; Pinilla, Leonor; Tena-Sempere, Manuel

    2016-01-01

    Kisspeptins, ligands of the receptor, Gpr54, are potent stimulators of puberty and fertility. Yet, whether direct kisspeptin actions on GnRH neurons are sufficient for the whole repertoire of their reproductive effects remains debatable. To dissect out direct vs. indirect effects of kisspeptins on GnRH neurons in vivo, we report herein the detailed reproductive/gonadotropic characterization of a Gpr54 null mouse line with selective re-introduction of Gpr54 expression only in GnRH cells (Gpr54−/−Tg; rescued). Despite preserved fertility, adult rescued mice displayed abnormalities in gonadal microstructure, with signs of precocious ageing in females and elevated LH levels with normal-to-low testosterone secretion in males. Gpr54−/−Tg rescued mice showed also altered gonadotropin responses to negative feedback withdrawal, while luteinizing hormone responses to various gonadotropic regulators were variably affected, with partially blunted relative (but not absolute) responses to kisspeptin-10, NMDA and the agonist of tachykinin receptors, NK2R. Our data confirm that direct effects of kisspeptins on GnRH cells are sufficient to attain fertility. Yet, such direct actions appear to be insufficient to completely preserve proper functionality of gonadotropic axis, suggesting a role of kisspeptin signaling outside GnRH cells. PMID:26755241

  14. Electric sales and revenue 1994

    SciTech Connect

    1995-11-01

    The Electric Sales and Revenue is prepared by the Coal and Electric Data and Renewables Division; Office of Coal, Nuclear, Electric and Alternate Fuels; Energy Information Administration (EIA); US Department of Energy. Information is provided on electricity sales, associated revenue, average revenue per kilowatthour sold, and number of consumers throughout the United States. The data provided in the Electric Sales and Revenue are presented at the national, Census division, State, and electric utility levels. The information is based on annual data reported by electric utilities for the calendar year ending December 31, 1994.

  15. Electric sales and revenue 1997

    SciTech Connect

    1998-10-01

    The Electric Sales and Revenue is prepared by the Electric Power Division; Office of Coal, Nuclear, Electric and Alternate Fuels; Energy Information Administration (EIA); US Department of Energy. Information is provided on electricity sales, associated revenue, average revenue per kilowatthour sold, and number of consumers throughout the US. The data provided in the Electric Sales and Revenue are presented at the national, Census division, State, and electric utility levels. The information is based on annual data reported by electric utilities for the calendar year ending December 31, 1997. 16 figs., 17 tabs.

  16. Sphingosine 1-phosphate-mediated α1B-adrenoceptor desensitization and phosphorylation. Direct and paracrine/autocrine actions

    PubMed Central

    Castillo-Badillo, Jean A.; Molina-Muñoz, Tzindilú; Romero-Ávila, M. Teresa; Vázquez-Macías, Aleida; Rivera, Richard; Chun, Jerold; García-Sáinz, J. Adolfo

    2012-01-01

    Sphingosine-1-phosphate-induced α1B-adrenergic receptor desensitization and phosphorylation was studied in rat-1 fibroblasts stably expressing enhanced green fluorescent protein-tagged adrenoceptors. Sphingosine-1-phosphate induced adrenoceptor desensitization and phosphorylation through a signaling cascade that involved phosphoinositide 3-kinase and protein kinase C activities. The autocrine/paracrine role of sphingosine-1-phosphate was also studied. It was observed that activation of receptor tyrosine kinases, such as insulin growth factor-1 (IGF-I) and epidermal growth factor (EGF) receptors increased sphingosine kinase activity. Such activation and consequent production of sphingosine-1-phosphate appears to be functionally relevant in IGF-I- and EGF-induced α1B-adrenoceptor phosphorylation and desensitization as evidenced by the following facts: a) expression of a catalytically inactive (dominant-negative) mutant of sphingosine kinase 1 or b) S1P1 receptor knockdown markedly reduced this growth factor action. This action of sphingosine-1-phosphate involves EGF receptor transactivation. In addition, taking advantage of the presence of the eGFP tag in the receptor construction, we showed that S1P was capable of inducing α1B-adrenergic receptor internalization and that its autocrine/paracrine generation was relevant for internalization induced by IGF-I. Four distinct hormone receptors and two autocrine/paracrine mediators participate in IGF-I receptor- α1B-adrenergic receptor crosstalk. PMID:22019450

  17. 31 CFR 56.2 - Sales price.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Sales price. 56.2 Section 56.2 Money and Finance: Treasury Regulations Relating to Money and Finance MONETARY OFFICES, DEPARTMENT OF THE TREASURY DOMESTIC GOLD AND SILVER OPERATIONS SALE OF SILVER § 56.2 Sales price. Sales of silver will be...

  18. 31 CFR 56.2 - Sales price.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Sales price. 56.2 Section 56.2 Money and Finance: Treasury Regulations Relating to Money and Finance MONETARY OFFICES, DEPARTMENT OF THE TREASURY DOMESTIC GOLD AND SILVER OPERATIONS SALE OF SILVER § 56.2 Sales price. Sales of silver will be...

  19. 31 CFR 56.2 - Sales price.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Sales price. 56.2 Section 56.2 Money and Finance: Treasury Regulations Relating to Money and Finance MONETARY OFFICES, DEPARTMENT OF THE TREASURY DOMESTIC GOLD AND SILVER OPERATIONS SALE OF SILVER § 56.2 Sales price. Sales of silver will be...

  20. 31 CFR 56.2 - Sales price.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Sales price. 56.2 Section 56.2 Money and Finance: Treasury Regulations Relating to Money and Finance DOMESTIC GOLD AND SILVER OPERATIONS SALE OF SILVER § 56.2 Sales price. Sales of silver will be at prices offered through the...

  1. 31 CFR 56.2 - Sales price.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Sales price. 56.2 Section 56.2 Money and Finance: Treasury Regulations Relating to Money and Finance MONETARY OFFICES, DEPARTMENT OF THE TREASURY DOMESTIC GOLD AND SILVER OPERATIONS SALE OF SILVER § 56.2 Sales price. Sales of silver will be...

  2. 48 CFR 245.7306 - Sales services.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Sales services. 245.7306... OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY Sale of Surplus Contractor Inventory 245.7306 Sales services. When sale services are needed, the plant clearance officer will document the reasons...

  3. 43 CFR 2566.2 - Public sale.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Public sale. 2566.2 Section 2566.2 Public... § 2566.2 Public sale. (a) Generally. The unreserved and unsold lots will be offered at public sale to the... Interior the superintendent of the sale will be, and he is hereby, authorized to make all appraisements...

  4. 30 CFR 556.12 - Supplemental sales.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false Supplemental sales. 556.12 Section 556.12... Management, General § 556.12 Supplemental sales. (a) The Secretary may conduct a supplemental sale in accordance with the provisions of this section. (b) Supplemental sales shall be governed by the...

  5. 24 CFR 291.90 - Sales methods.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Sales methods. 291.90 Section 291... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF HUD-ACQUIRED SINGLE FAMILY PROPERTY Disposition by Sale § 291.90 Sales methods. HUD will prescribe the terms and conditions for all methods of sale. HUD may,...

  6. 43 CFR 3602.40 - Competitive sales.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Competitive sales. 3602.40 Section 3602.40..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL MATERIALS DISPOSAL Mineral Materials Sales Competitive Sales § 3602.40 Competitive sales. In addition to the following sections, §§ 3602.41 through...

  7. 24 CFR 291.90 - Sales methods.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Sales methods. 291.90 Section 291... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF HUD-ACQUIRED SINGLE FAMILY PROPERTY Disposition by Sale § 291.90 Sales methods. HUD will prescribe the terms and conditions for all methods of sale. HUD may,...

  8. 43 CFR 2566.2 - Public sale.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Public sale. 2566.2 Section 2566.2 Public... § 2566.2 Public sale. (a) Generally. The unreserved and unsold lots will be offered at public sale to the... Interior the superintendent of the sale will be, and he is hereby, authorized to make all appraisements...

  9. 43 CFR 2566.2 - Public sale.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Public sale. 2566.2 Section 2566.2 Public... § 2566.2 Public sale. (a) Generally. The unreserved and unsold lots will be offered at public sale to the... Interior the superintendent of the sale will be, and he is hereby, authorized to make all appraisements...

  10. 43 CFR 3602.30 - Noncompetitive sales.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Noncompetitive sales. 3602.30 Section 3602..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL MATERIALS DISPOSAL Mineral Materials Sales Noncompetitive Sales § 3602.30 Noncompetitive sales. In addition to the following sections, §§ 3602.31...

  11. 24 CFR 291.90 - Sales methods.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Sales methods. 291.90 Section 291... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF HUD-ACQUIRED SINGLE FAMILY PROPERTY Disposition by Sale § 291.90 Sales methods. HUD will prescribe the terms and conditions for all methods of sale. HUD may,...

  12. 43 CFR 3602.30 - Noncompetitive sales.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Noncompetitive sales. 3602.30 Section 3602..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL MATERIALS DISPOSAL Mineral Materials Sales Noncompetitive Sales § 3602.30 Noncompetitive sales. In addition to the following sections, §§ 3602.31...

  13. 43 CFR 2566.2 - Public sale.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Public sale. 2566.2 Section 2566.2 Public... § 2566.2 Public sale. (a) Generally. The unreserved and unsold lots will be offered at public sale to the... Interior the superintendent of the sale will be, and he is hereby, authorized to make all appraisements...

  14. 7 CFR 46.25 - Auction sales.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Auction sales. 46.25 Section 46.25 Agriculture... THAN RULES OF PRACTICE) UNDER THE PERISHABLE AGRICULTURAL COMMODITIES ACT, 1930 Auction Sales § 46.25 Auction sales. Commission merchants, dealers and brokers who offer produce for sale through...

  15. 30 CFR 556.12 - Supplemental sales.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false Supplemental sales. 556.12 Section 556.12... Management, General § 556.12 Supplemental sales. (a) The Secretary may conduct a supplemental sale in accordance with the provisions of this section. (b) Supplemental sales shall be governed by the...

  16. 43 CFR 3602.40 - Competitive sales.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Competitive sales. 3602.40 Section 3602.40..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL MATERIALS DISPOSAL Mineral Materials Sales Competitive Sales § 3602.40 Competitive sales. In addition to the following sections, §§ 3602.41 through...

  17. 43 CFR 3602.30 - Noncompetitive sales.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Noncompetitive sales. 3602.30 Section 3602..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL MATERIALS DISPOSAL Mineral Materials Sales Noncompetitive Sales § 3602.30 Noncompetitive sales. In addition to the following sections, §§ 3602.31...

  18. 43 CFR 3602.40 - Competitive sales.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Competitive sales. 3602.40 Section 3602.40..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL MATERIALS DISPOSAL Mineral Materials Sales Competitive Sales § 3602.40 Competitive sales. In addition to the following sections, §§ 3602.41 through...

  19. 30 CFR 556.12 - Supplemental sales.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false Supplemental sales. 556.12 Section 556.12... Management, General § 556.12 Supplemental sales. (a) The Secretary may conduct a supplemental sale in accordance with the provisions of this section. (b) Supplemental sales shall be governed by the...

  20. 43 CFR 3602.40 - Competitive sales.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Competitive sales. 3602.40 Section 3602.40..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL MATERIALS DISPOSAL Mineral Materials Sales Competitive Sales § 3602.40 Competitive sales. In addition to the following sections, §§ 3602.41 through...

  1. 7 CFR 46.25 - Auction sales.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Auction sales. 46.25 Section 46.25 Agriculture... THAN RULES OF PRACTICE) UNDER THE PERISHABLE AGRICULTURAL COMMODITIES ACT, 1930 Auction Sales § 46.25 Auction sales. Commission merchants, dealers and brokers who offer produce for sale through...

  2. 43 CFR 3602.30 - Noncompetitive sales.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Noncompetitive sales. 3602.30 Section 3602..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL MATERIALS DISPOSAL Mineral Materials Sales Noncompetitive Sales § 3602.30 Noncompetitive sales. In addition to the following sections, §§ 3602.31...

  3. 24 CFR 291.90 - Sales methods.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Sales methods. 291.90 Section 291... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF HUD-ACQUIRED SINGLE FAMILY PROPERTY Disposition by Sale § 291.90 Sales methods. HUD will prescribe the terms and conditions for all methods of sale. HUD may,...

  4. Paid to Persuade: Careers in Sales

    ERIC Educational Resources Information Center

    Torpey, Elka Maria

    2011-01-01

    Workers who make a living in sales are paid to persuade others to buy goods and services. Just about anything, from apricots to zip-line tours, needs an intermediary to move from producer to buyer. That go-between person is the sales worker. Sales jobs are numerous. In May 2010, there were over 13 million wage and salary sales workers in the…

  5. 24 CFR 291.90 - Sales methods.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Sales methods. 291.90 Section 291....90 Sales methods. HUD will prescribe the terms and conditions for all methods of sale. HUD may, in... following methods of sale: (a) Future REO acquisition method. The Future Real Estate-Owned (REO)...

  6. Directivity patterns and pulse profiles of ultrasound emitted by laser action on interface between transparent and opaque solids: Analytical theory

    SciTech Connect

    Nikitin, Sergey M. E-mail: vitali.goussev@univ-lemans.fr; Tournat, Vincent; Chigarev, Nikolay; Castagnede, Bernard; Gusev, Vitalyi E-mail: vitali.goussev@univ-lemans.fr; Bulou, Alain; Zerr, Andreas

    2014-01-28

    The analytical theory for the directivity patterns of ultrasounds emitted from laser-irradiated interface between two isotropic solids is developed. It is valid for arbitrary combinations of transparent and opaque materials. The directivity patterns are derived both in two-dimensional and in three-dimensional geometries, by accounting for the specific features of the sound generation by the photo-induced mechanical stresses distributed in the volume, essential in the laser ultrasonics. In particular, the theory accounts for the contribution to the emitted propagating acoustic fields from the converted by the interface evanescent photo-generated compression-dilatation waves. The precise analytical solutions for the profiles of longitudinal and shear acoustic pulses emitted in different directions are proposed. The developed theory can be applied for dimensional scaling, optimization, and interpretation of the high-pressure laser ultrasonics experiments in diamond anvil cell.

  7. Ethanol directly depresses AMPA and NMDA glutamate currents in spinal cord motor neurons independent of actions on GABAA or glycine receptors.

    PubMed

    Wang, M Y; Rampil, I J; Kendig, J J

    1999-07-01

    Ethanol is a general anesthetic agent as defined by abolition of movement in response to noxious stimulation. This anesthetic endpoint is due to spinal anesthetic actions. This study was designed to test the hypothesis that ethanol acts directly on motor neurons to inhibit excitatory synaptic transmission at glutamate receptors. Whole cell recordings were made in visually identified motor neurons in spinal cord slices from 14- to 23-day-old rats. Currents were evoked by stimulating a dorsal root fragment or by brief pulses of glutamate. Ethanol at general anesthetic concentrations (50-200 mM) depressed both responses. Ethanol also depressed glutamate-evoked responses in the presence of tetrodotoxin (300 nM), showing that its actions are postsynaptic. Block of inhibitory gamma-aminobutyric acidA and glycine receptors by bicuculline (50 microM) and strychnine (5 microM), respectively, did not significantly reduce the effects of ethanol on glutamate currents. Ethanol also depressed glutamate-evoked currents when the inhibitory receptors were blocked and either D, L-2-amino-5-phosphonopentanoic acid (40 microM) or 6-cyano-7-nitroquinoxaline-2,3-dione disodium (10 microM) were applied to block N-methyl-D-aspartate or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate receptors, respectively. The results show that ethanol exerts direct depressant effects on both alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and N-methyl-D-aspartate glutamate currents in motor neurons. Enhancement of gamma-aminobutyric acidA and glycine inhibition is not required for this effect. Direct depression of glutamatergic excitatory transmission by a postsynaptic action on motor neurons thus may contribute to general anesthesia as defined by immobility in response to a noxious stimulus. PMID:10381800

  8. 24 CFR 1715.20 - Unlawful sales practices-regulatory provisions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... unlawful sales practice for any developer or agent, directly or indirectly, to: (a) Give the Property... the terms of a contract or any other document used by the developer as a sales inducement. (e) Refuse... basis of the increase in value shall rest upon the developer. (i) Represent a lot as a homesite...

  9. 24 CFR 1715.20 - Unlawful sales practices-regulatory provisions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... unlawful sales practice for any developer or agent, directly or indirectly, to: (a) Give the Property... the terms of a contract or any other document used by the developer as a sales inducement. (e) Refuse... basis of the increase in value shall rest upon the developer. (i) Represent a lot as a homesite...

  10. 41 CFR 102-38.295 - May we retain sales proceeds?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... costs of care and handling directly related to the sale of personal property by the SC (e.g., shipment to the SC, storage pending sale, and inspection by prospective buyers). (c) After accounting for... Governmentwide costs to support the eFAS Internet portal and Governmentwide reporting requirements) incurred...

  11. 78 FR 59952 - Notice of National Petroleum Reserve-Alaska Oil and Gas Lease Sale 2013 and Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-30

    ... Bureau of Land Management Notice of National Petroleum Reserve-Alaska Oil and Gas Lease Sale 2013 and... Petroleum Reserve- Alaska AGENCY: Bureau of Land Management, Interior. ACTION: Notice. SUMMARY: The Bureau... National Petroleum Reserve-Alaska oil and gas lease sale bid opening for tracts in the National...

  12. 77 FR 61022 - Notice of National Petroleum Reserve-Alaska Oil and Gas Lease Sale 2012 and Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-05

    ... Bureau of Land Management Notice of National Petroleum Reserve-Alaska Oil and Gas Lease Sale 2012 and... Petroleum Reserve-- Alaska AGENCY: Bureau of Land Management, Interior. ACTION: Notice. SUMMARY: The Bureau... notifies the public that it will hold a National Petroleum Reserve-Alaska oil and gas lease sale...

  13. 76 FR 174 - International Business Machines (IBM), Global Sales Operations Organization, Sales and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-03

    ..., 2010 (75 FR 71460). The workers provide Relations Analyst and Band 8 Program Manager services. At the... Employment and Training Administration International Business Machines (IBM), Global Sales Operations...; International Business Machines (IBM), Global Sales Operations Organization, Sales and Distribution...

  14. Internet cigarette sales and Native American sovereignty: political and public health contexts.

    PubMed

    Samuel, Kari A; Ribisl, Kurt M; Williams, Rebecca S

    2012-05-01

    Internet cigarette vendors (ICVs) advertise low prices for tobacco products, subverting public health policy efforts to curtail smoking by raising prices. Many online retailers in the United States claim affiliation with Native American tribes and share in tribal tax-free status. Sales of discounted cigarettes from both online vendors and brick-and-mortar stores have angered non-Native retailers and triggered enforcement actions by state and federal governments in the United States concerned over lost cigarette excise tax revenue. Examination of the history and politics of cigarette sales on reservations and attempts to regulate Internet cigarette sales highlights the potential role for greater use of negotiated intergovernmental agreements to address reservation-based tobacco sales. Our review notes global parallels and explicates history and politics of such regulation in the United States, and offers background for collaborative efforts to regulate tobacco sales and decrease tobacco use. PMID:22358120

  15. Internet cigarette sales and Native American sovereignty: political and public health contexts.

    PubMed

    Samuel, Kari A; Ribisl, Kurt M; Williams, Rebecca S

    2012-05-01

    Internet cigarette vendors (ICVs) advertise low prices for tobacco products, subverting public health policy efforts to curtail smoking by raising prices. Many online retailers in the United States claim affiliation with Native American tribes and share in tribal tax-free status. Sales of discounted cigarettes from both online vendors and brick-and-mortar stores have angered non-Native retailers and triggered enforcement actions by state and federal governments in the United States concerned over lost cigarette excise tax revenue. Examination of the history and politics of cigarette sales on reservations and attempts to regulate Internet cigarette sales highlights the potential role for greater use of negotiated intergovernmental agreements to address reservation-based tobacco sales. Our review notes global parallels and explicates history and politics of such regulation in the United States, and offers background for collaborative efforts to regulate tobacco sales and decrease tobacco use.

  16. Nitrous oxide directly inhibits action potential-dependent neurotransmission from single presynaptic boutons adhering to rat hippocampal CA3 neurons.

    PubMed

    Wakita, Masahito; Kotani, Naoki; Yamaga, Toshitaka; Akaike, Norio

    2015-09-01

    We evaluated the effects of N2O on synaptic transmission using a preparation of mechanically dissociated rat hippocampal CA3 neurons that allowed assays of single bouton responses evoked from native functional nerve endings. We studied the effects of N2O on GABAA, glutamate, AMPA and NMDA receptor-mediated currents (IGABA, IGlu, IAMPA and INMDA) elicited by exogenous application of GABA, glutamate, (S)-AMPA, and NMDA and spontaneous, miniature, and evoked GABAergic inhibitory and glutamatergic excitatory postsynaptic current (sIPSC, mIPSC, eIPSC, sEPSC, mEPSC and eEPSC) in mechanically dissociated CA3 neurons. eIPSC and eEPSC were evoked by focal electrical stimulation of a single bouton. Administration of 70% N2O altered neither IGABA nor the frequency and amplitude of both sIPSCs and mIPSCs. In contrast, N2O decreased the amplitude of eIPSCs, while increasing failure rates (Rf) and paired-pulse ratios (PPR) in a concentration-dependent manner. On the other hand, N2O decreased IGlu, IAMPA and INMDA. Again N2O did not change the frequency and amplitude of either sEPSCs of mEPSCs. N2O also decreased amplitudes of eEPSCs with increased Rf and PPR. The decay phases of all synaptic responses were unchanged. The present results indicated that N2O inhibits the activation of AMPA/KA and NMDA receptors and also that N2O preferentially depress the action potential-dependent GABA and glutamate releases but had little effects on spontaneous and miniature releases. PMID:26343381

  17. Green synthesis of silver nanoparticles using Terminalia cuneata and its catalytic action in reduction of direct yellow-12 dye.

    PubMed

    Edison, Thomas Nesakumar Jebakumar Immanuel; Lee, Yong Rok; Sethuraman, Mathur Gopalakrishnan

    2016-05-15

    Facile green synthesis of silver nanoparticles (AgNPs) using aqueous bark extract of Terminalia cuneata has been reported in this article. The effects of concentration of the extract, reaction time and pH were studied by UV-Vis spectroscopy. Appearance of yellow color with λmax around ~420 nm suggested the formation of AgNPs. The stable AgNPs were further characterized by Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), dynamic light scattering (DLS) with zeta potential and high resolution transmission electron microscopy (HR-TEM) with energy dispersive X-ray spectroscopy (EDS) analysis. The synthesized AgNPs were in the size range of 25-50 nm with a distorted spherical shape identified from HR-TEM analysis. The catalytic activity of AgNPs on the reduction of direct yellow-12 using NaBH4 was analyzed using a UV-Vis spectrophotometer. This study showed the efficacy of biogenic AgNPs in catalyzing the reduction of direct yellow-12. PMID:26967513

  18. Green synthesis of silver nanoparticles using Terminalia cuneata and its catalytic action in reduction of direct yellow-12 dye

    NASA Astrophysics Data System (ADS)

    Edison, Thomas Nesakumar Jebakumar Immanuel; Lee, Yong Rok; Sethuraman, Mathur Gopalakrishnan

    2016-05-01

    Facile green synthesis of silver nanoparticles (AgNPs) using aqueous bark extract of Terminalia cuneata has been reported in this article. The effects of concentration of the extract, reaction time and pH were studied by UV-Vis spectroscopy. Appearance of yellow color with λmax around ~ 420 nm suggested the formation of AgNPs. The stable AgNPs were further characterized by Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), dynamic light scattering (DLS) with zeta potential and high resolution transmission electron microscopy (HR-TEM) with energy dispersive X-ray spectroscopy (EDS) analysis. The synthesized AgNPs were in the size range of 25-50 nm with a distorted spherical shape identified from HR-TEM analysis. The catalytic activity of AgNPs on the reduction of direct yellow-12 using NaBH4 was analyzed using a UV-Vis spectrophotometer. This study showed the efficacy of biogenic AgNPs in catalyzing the reduction of direct yellow-12.

  19. A novel strategy for dissecting goal-directed action and arousal components of motivated behavior with a progressive hold-down task.

    PubMed

    Bailey, Matthew R; Jensen, Greg; Taylor, Kathleen; Mezias, Chris; Williamson, Cait; Silver, Rae; Simpson, Eleanor H; Balsam, Peter D

    2015-06-01

    Motivation serves 2 important functions: It guides actions to be goal-directed, and it provides the energy and vigor required to perform the work necessary to meet those goals. Dissociating these 2 processes with existing behavioral assays has been a challenge. In this article, we report a novel experimental strategy to distinguish the 2 processes in mice. First, we characterize a novel motivation assay in which animals must hold down a lever for progressively longer intervals to earn each subsequent reward; we call this the progressive hold-down (PHD) task. We find that performance on the PHD task is sensitive to both food deprivation level and reward value. Next, we use a dose of methamphetamine (METH) 1.0 mg/kg, to evaluate behavior in both the progressive ratio (PR) and PHD tasks. Treatment with METH leads to more persistent lever pressing for food rewards in the PR. In the PHD task, we found that METH increased arousal, which leads to numerous bouts of hyperactive responding but neither increases nor impairs goal-directed action. The results demonstrate that these tools enable a more precise understanding of the underlying processes being altered in manipulations that alter motivated behavior.

  20. Function of the Histone-Like Protein H-NS in Motility of Escherichia coli: Multiple Regulatory Roles Rather than Direct Action at the Flagellar Motor

    PubMed Central

    Kim, Eun A

    2015-01-01

    ABSTRACT A number of investigations of Escherichia coli have suggested that the DNA-binding protein H-NS, in addition to its well-known functions in chromosome organization and gene regulation, interacts directly with the flagellar motor to modulate its function. Here, in a study initially aimed at characterizing the H-NS/motor interaction further, we identify problems and limitations in the previous work that substantially weaken the case for a direct H-NS/motor interaction. Null hns mutants are immotile, largely owing to the downregulation of the flagellar master regulators FlhD and FlhC. We, and others, previously reported that an hns mutant remains poorly motile even when FlhDC are expressed constitutively. In the present work, we use better-engineered strains to show that the motility defect in a Δhns, FlhDC-constitutive strain is milder than that reported previously and does not point to a direct action of H-NS at the motor. H-NS regulates numerous genes and might influence motility via a number of regulatory molecules besides FlhDC. To examine the sources of the motility defect that persists in an FlhDC-constitutive Δhns mutant, we measured transcript levels and overexpression effects of a number of genes in candidate regulatory pathways. The results indicate that H-NS influences motility via multiple regulatory linkages that include, minimally, the messenger molecule cyclic di-GMP, the biofilm regulatory protein CsgD, and the sigma factors σS and σF. The results are in accordance with the more standard view of H-NS as a regulator of gene expression rather than a direct modulator of flagellar motor performance. IMPORTANCE Data from a number of previous studies have been taken to indicate that the nucleoid-organizing protein H-NS influences motility not only by its well-known DNA-based mechanisms but also by binding directly to the flagellar motor to alter function. In this study, H-NS is shown to influence motility through diverse regulatory pathways

  1. 77 FR 69437 - 36(b)(1) Arms Sales Notification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-19

    ... needs these aircraft to sustain its aging fleet, which faces increasing obsolescence. The proposed sale... only solutions. Classified elements include Selective Availability Anti-spoofing Module (SAASM) for...-directed anti-aircraft artillery (AAA), radar command-guided missiles, radar homing guided missiles,...

  2. 19 CFR 351.410 - Differences in circumstances of sale

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Differences in circumstances of sale 351.410 Section 351.410 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND... commissions, credit expenses, guarantees, and warranties, that result from, and bear a direct relationship...

  3. 75 FR 17156 - Gulf of Mexico, Outer Continental Shelf, Western Planning Area, Oil and Gas Lease Sale 215 (2010...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-05

    ... Minerals Management Service Gulf of Mexico, Outer Continental Shelf, Western Planning Area, Oil and Gas Lease Sale 215 (2010) Environmental Assessment AGENCY: Minerals Management Service, Interior. ACTION: Notice of availability of an environmental assessment. SUMMARY: The Minerals Management Service (MMS)...

  4. Site-directed mutagenesis of the heterotrimeric killer toxin zymocin identifies residues required for early steps in toxin action.

    PubMed

    Wemhoff, Sabrina; Klassen, Roland; Meinhardt, Friedhelm

    2014-10-01

    Zymocin is a Kluyveromyces lactis protein toxin composed of αβγ subunits encoded by the cytoplasmic virus-like element k1 and functions by αβ-assisted delivery of the anticodon nuclease (ACNase) γ into target cells. The toxin binds to cells' chitin and exhibits chitinase activity in vitro that might be important during γ import. Saccharomyces cerevisiae strains carrying k1-derived hybrid elements deficient in either αβ (k1ORF2) or γ (k1ORF4) were generated. Loss of either gene abrogates toxicity, and unexpectedly, Orf2 secretion depends on Orf4 cosecretion. Functional zymocin assembly can be restored by nuclear expression of k1ORF2 or k1ORF4, providing an opportunity to conduct site-directed mutagenesis of holozymocin. Complementation required active site residues of α's chitinase domain and the sole cysteine residue of β (Cys250). Since βγ are reportedly disulfide linked, the requirement for the conserved γ C231 was probed. Toxicity of intracellularly expressed γ C231A indicated no major defect in ACNase activity, while complementation of k1ΔORF4 by γ C231A was lost, consistent with a role of β C250 and γ C231 in zymocin assembly. To test the capability of αβ to carry alternative cargos, the heterologous ACNase from Pichia acaciae (P. acaciae Orf2 [PaOrf2]) was expressed, along with its immunity gene, in k1ΔORF4. While efficient secretion of PaOrf2 was detected, suppression of the k1ΔORF4-derived k1Orf2 secretion defect was not observed. Thus, the dependency of k1Orf2 on k1Orf4 cosecretion needs to be overcome prior to studying αβ's capability to deliver other cargo proteins into target cells. PMID:25128337

  5. MYB Promotes Desmoplasia in Pancreatic Cancer through Direct Transcriptional Up-regulation and Cooperative Action of Sonic Hedgehog and Adrenomedullin.

    PubMed

    Bhardwaj, Arun; Srivastava, Sanjeev K; Singh, Seema; Tyagi, Nikhil; Arora, Sumit; Carter, James E; Khushman, Moh'd; Singh, Ajay P

    2016-07-29

    Extensive desmoplasia is a prominent pathological characteristic of pancreatic cancer (PC) that not only impacts tumor development, but therapeutic outcome as well. Recently, we demonstrated a novel role of MYB, an oncogenic transcription factor, in PC growth and metastasis. Here we studied its effect on pancreatic tumor histopathology and associated molecular and biological mechanisms. Tumor-xenografts derived from orthotopic-inoculation of MYB-overexpressing PC cells exhibited far-greater desmoplasia in histological analyses compared with those derived from MYB-silenced PC cells. These findings were further confirmed by immunostaining of tumor-xenograft sections with collagen-I, fibronectin (major extracellular-matrix proteins), and α-SMA (well-characterized marker of myofibroblasts or activated pancreatic stellate cells (PSCs)). Likewise, MYB-overexpressing PC cells provided significantly greater growth benefit to PSCs in a co-culture system as compared with the MYB-silenced cells. Interrogation of deep-sequencing data from MYB-overexpressing versus -silenced PC cells identified Sonic-hedgehog (SHH) and Adrenomedullin (ADM) as two differentially-expressed genes among others, which encode for secretory ligands involved in tumor-stromal cross-talk. In-silico analyses predicted putative MYB-binding sites in SHH and ADM promoters, which was later confirmed by chromatin-immunoprecipitation. A cooperative role of SHH and ADM in growth promotion of PSCs was confirmed in co-culture by using their specific-inhibitors and exogenous recombinant-proteins. Importantly, while SHH acted exclusively in a paracrine fashion on PSCs and influenced the growth of PC cells only indirectly, ADM could directly impact the growth of both PC cells and PSCs. In summary, we identified MYB as novel regulator of pancreatic tumor desmoplasia, which is suggestive of its diverse roles in PC pathobiology. PMID:27246849

  6. Enforcing regulations on alcohol sales and use as universal environmental prevention.

    PubMed

    Villalbí, Joan R; Bartroli, Montserrat; Bosque-Prous, Marina; Guitart, Anna M; Serra-Batiste, Enric; Casas, Conrad; Brugal, M Teresa

    2015-12-15

    The informal social control over alcohol consumption that was traditional in Southern European countries has weakened. At the same time there is an increase in binge drinking and drunkenness among young people in Spain. To mitigate this problem, regulations on alcohol and driving and restrictions on the sale and consumption of alcohol have been adopted. This paper documents the current regulations in the city of Barcelona and describes efforts to enforce them and their outcomes. Data from the municipal information systems on infringements reported for the period 2008-13 are provided. There is an increasing pressure of municipal services to enforce the rules in two areas: a) alcohol sales at night (retailers); and b) consumption in the public space (citizens). An increase in the controls of drink-driving has also taken place, and the proportion above legal limits has decreased. The largest relative increase occurred in the control of retailers. In Barcelona interventions are made to limit the supply and consumption of alcohol at low cost and during the night, and of driving under the influence of alcohol. There have been no documented episodes of massive drinking in public spaces (known as 'botellón') in the city. These actions, which complement other preventive efforts based on health education, can change the social perceptions of alcohol by minors in a direction less favorable to consumption, promoting environmental prevention.

  7. Enforcing regulations on alcohol sales and use as universal environmental prevention.

    PubMed

    Villalbí, Joan R; Bartroli, Montserrat; Bosque-Prous, Marina; Guitart, Anna M; Serra-Batiste, Enric; Casas, Conrad; Brugal, M Teresa

    2015-01-01

    The informal social control over alcohol consumption that was traditional in Southern European countries has weakened. At the same time there is an increase in binge drinking and drunkenness among young people in Spain. To mitigate this problem, regulations on alcohol and driving and restrictions on the sale and consumption of alcohol have been adopted. This paper documents the current regulations in the city of Barcelona and describes efforts to enforce them and their outcomes. Data from the municipal information systems on infringements reported for the period 2008-13 are provided. There is an increasing pressure of municipal services to enforce the rules in two areas: a) alcohol sales at night (retailers); and b) consumption in the public space (citizens). An increase in the controls of drink-driving has also taken place, and the proportion above legal limits has decreased. The largest relative increase occurred in the control of retailers. In Barcelona interventions are made to limit the supply and consumption of alcohol at low cost and during the night, and of driving under the influence of alcohol. There have been no documented episodes of massive drinking in public spaces (known as 'botellón') in the city. These actions, which complement other preventive efforts based on health education, can change the social perceptions of alcohol by minors in a direction less favorable to consumption, promoting environmental prevention. PMID:26706811

  8. 43 CFR 3120.5 - Competitive sale.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Competitive sale. 3120.5 Section 3120.5 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... Competitive sale....

  9. 43 CFR 3120.5 - Competitive sale.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Competitive sale. 3120.5 Section 3120.5 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... Competitive sale....

  10. 43 CFR 3120.5 - Competitive sale.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Competitive sale. 3120.5 Section 3120.5 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... Competitive sale....

  11. 43 CFR 3120.5 - Competitive sale.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Competitive sale. 3120.5 Section 3120.5 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... Competitive sale....

  12. 32 CFR 171.5 - Sale procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... WILDFIRE SUPPRESSION AIRCRAFT TRANSFER ACT OF 1996 § 171.5 Sale procedures. Disposal of aircraft and... suppression sale if there is indication that reoffer may be successful, or, (ii) With DLA concurrence,...

  13. 32 CFR 171.5 - Sale procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... WILDFIRE SUPPRESSION AIRCRAFT TRANSFER ACT OF 1996 § 171.5 Sale procedures. Disposal of aircraft and... suppression sale if there is indication that reoffer may be successful, or, (ii) With DLA concurrence,...

  14. 32 CFR 171.5 - Sale procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... WILDFIRE SUPPRESSION AIRCRAFT TRANSFER ACT OF 1996 § 171.5 Sale procedures. Disposal of aircraft and... suppression sale if there is indication that reoffer may be successful, or, (ii) With DLA concurrence,...

  15. 32 CFR 171.5 - Sale procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... WILDFIRE SUPPRESSION AIRCRAFT TRANSFER ACT OF 1996 § 171.5 Sale procedures. Disposal of aircraft and... suppression sale if there is indication that reoffer may be successful, or, (ii) With DLA concurrence,...

  16. 32 CFR 171.5 - Sale procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... suppression sale if there is indication that reoffer may be successful, or, (ii) With DLA concurrence, as... contract. (i) Sales contracts include provisions for on-site visits to the purchaser's place(s) of...

  17. Curriculum for Sale?

    ERIC Educational Resources Information Center

    Melehy, Hassan

    2012-01-01

    Given the widespread tendency to direct budget cuts in higher education toward areas perceived as less essential to economic productivity, there is not a single college or university humanities program in the United States that would not benefit from philanthropy. However, because some moneyed interests use the current crisis as a pretext to…

  18. 43 CFR 4150.4-5 - Sale.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Sale. 4150.4-5 Section 4150.4-5 Public... Grazing Use § 4150.4-5 Sale. If the livestock are not redeemed on or before the date and time fixed for their sale, they shall be offered at public sale to the highest bidder by the authorized officer...

  19. 43 CFR 4150.4-5 - Sale.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Sale. 4150.4-5 Section 4150.4-5 Public... Grazing Use § 4150.4-5 Sale. If the livestock are not redeemed on or before the date and time fixed for their sale, they shall be offered at public sale to the highest bidder by the authorized officer...

  20. 43 CFR 4150.4-5 - Sale.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Sale. 4150.4-5 Section 4150.4-5 Public... Grazing Use § 4150.4-5 Sale. If the livestock are not redeemed on or before the date and time fixed for their sale, they shall be offered at public sale to the highest bidder by the authorized officer...

  1. 43 CFR 4150.4-5 - Sale.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Sale. 4150.4-5 Section 4150.4-5 Public... Grazing Use § 4150.4-5 Sale. If the livestock are not redeemed on or before the date and time fixed for their sale, they shall be offered at public sale to the highest bidder by the authorized officer...

  2. Direct effects of exendin-(9,39) and GLP-1-(9,36)amide on insulin action, β-cell function, and glucose metabolism in nondiabetic subjects.

    PubMed

    Sathananthan, Matheni; Farrugia, Luca P; Miles, John M; Piccinini, Francesca; Dalla Man, Chiara; Zinsmeister, Alan R; Cobelli, Claudio; Rizza, Robert A; Vella, Adrian

    2013-08-01

    Exendin-(9,39) is a competitive antagonist of glucagon-like peptide-1 (GLP-1) at its receptor. However, it is unclear if it has direct and unique effects of its own. We tested the hypothesis that exendin-(9,39) and GLP-1-(9,36)amide have direct effects on hormone secretion and β-cell function as well as glucose metabolism in healthy subjects. Glucose containing [3-(3)H]glucose was infused to mimic the systemic appearance of glucose after a meal. Saline, GLP-1-(9,36)amide, or exendin-(9,39) at 30 pmol/kg/min (Ex 30) or 300 pmol/kg/min (Ex 300) were infused in random order on separate days. Integrated glucose concentrations were slightly but significantly increased by exendin-(9,39) (365 ± 43 vs. 383 ± 35 vs. 492 ± 49 vs. 337 ± 50 mmol per 6 h, saline, Ex 30, Ex 300, and GLP-1-[9,36]amide, respectively; P = 0.05). Insulin secretion did not differ among groups. However, insulin action was lowered by exendin-(9,39) (25 ± 4 vs. 20 ± 4 vs. 18 ± 3 vs. 21 ± 4 10(-4) dL/kg[min per μU/mL]; P = 0.02), resulting in a lower disposition index (DI) during exendin-(9,39) infusion (1,118 ± 118 vs. 816 ± 83 vs. 725 ± 127 vs. 955 ± 166 10(-14) dL/kg/min(2) per pmol/L; P = 0.003). Endogenous glucose production and glucose disappearance did not differ significantly among groups. We conclude that exendin-(9,39), but not GLP-1-(9,36)amide, decreases insulin action and DI in healthy humans.

  3. Pricing of GPO Sales Publications.

    ERIC Educational Resources Information Center

    Schwarzkopf, LeRoy C.

    This report analyzes the pricing policy of the Government Printing Office (GPO) for publications sold to the public. It discusses the sharp rise in prices for GPO sales publications from November 1972 through 1975. This is a detailed report which expands on the summary report prepared by the author as chairman of the Pricing Subcommittee, GPO…

  4. The Student Body, for Sale

    ERIC Educational Resources Information Center

    Troop, Don

    2013-01-01

    The sale of bodily goods or services--"body commodification"--is nothing new among college students. But strides in medical technology, the encroachment of market values on all facets of life, and the reach and culture of the Internet have combined to create a fertile environment for people who want or need to exploit the value of their skin or…

  5. Advertising and Sales Promotion Guide.

    ERIC Educational Resources Information Center

    North Carolina State Dept. of Public Instruction, Raleigh. Div. of Vocational Education.

    This document contains teacher materials for a 4-unit, 1-year marketing education course in advertising and sales promotion offered in grades 11 and 12 in North Carolina. The preface contains a rationale for the development of the course, a course description, course objectives, a list of the instructional units of the course, and a list of the…

  6. 36 CFR 223.227 - Sale advertisement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Sale advertisement. 223.227... DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER Special Forest Products Advertisement and Bids § 223.227 Sale advertisement. (a) The Forest Service shall advertise any special forest products sales with an appraised...

  7. 32 CFR 644.544 - Negotiated sales.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ESTATE HANDBOOK Disposal Sale Procedure § 644.544 Negotiated sales. (a) To private parties. Negotiated... requirement for appraisal by contract. (2) All other proposals to negotiate sales without advertising will be...) Appraisal by contract. Pursuant to Federal Property Management Regulation, § 101-47.304-9(b), where...

  8. 14 CFR 381.9 - Sales.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Sales. 381.9 Section 381.9 Aeronautics and... SPECIAL EVENT TOURS § 381.9 Sales. (a) Except as provided in paragraph (b) of this section: (1) No... booking must be returned within 3 business days. (2) Upon acceptance of the money for a sale, the...

  9. 7 CFR 1955.148 - Auction sales.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 14 2011-01-01 2011-01-01 false Auction sales. 1955.148 Section 1955.148 Agriculture... REGULATIONS (CONTINUED) PROPERTY MANAGEMENT Disposal of Inventory Property General § 1955.148 Auction sales. This section provides guidance on the sale of all inventory property by auction, except FSA...

  10. 14 CFR 381.9 - Sales.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Sales. 381.9 Section 381.9 Aeronautics and... SPECIAL EVENT TOURS § 381.9 Sales. (a) Except as provided in paragraph (b) of this section: (1) No... booking must be returned within 3 business days. (2) Upon acceptance of the money for a sale, the...

  11. 24 CFR 290.13 - Negotiated sales.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Negotiated sales. 290.13 Section... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.13 Negotiated sales. When HUD conducts a negotiated...

  12. 7 CFR 1955.148 - Auction sales.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Auction sales. 1955.148 Section 1955.148 Agriculture... REGULATIONS (CONTINUED) PROPERTY MANAGEMENT Disposal of Inventory Property General § 1955.148 Auction sales. This section provides guidance on the sale of all inventory property by auction, except FSA...

  13. 7 CFR 1955.148 - Auction sales.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 14 2014-01-01 2014-01-01 false Auction sales. 1955.148 Section 1955.148 Agriculture... REGULATIONS (CONTINUED) PROPERTY MANAGEMENT Disposal of Inventory Property General § 1955.148 Auction sales. This section provides guidance on the sale of all inventory property by auction, except FSA...

  14. 43 CFR 5422.1 - Cruise sales.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Cruise sales. 5422.1 Section 5422.1 Public... OF THE INTERIOR FOREST MANAGEMENT (5000) PREPARATION FOR SALE Volume Measurements § 5422.1 Cruise sales. As the general practice, the Bureau will sell timber on a tree cruise basis....

  15. 7 CFR 1955.148 - Auction sales.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 14 2013-01-01 2013-01-01 false Auction sales. 1955.148 Section 1955.148 Agriculture... REGULATIONS (CONTINUED) PROPERTY MANAGEMENT Disposal of Inventory Property General § 1955.148 Auction sales. This section provides guidance on the sale of all inventory property by auction, except FSA...

  16. 24 CFR 290.13 - Negotiated sales.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Negotiated sales. 290.13 Section... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.13 Negotiated sales. When HUD conducts a negotiated...

  17. 14 CFR 381.9 - Sales.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Sales. 381.9 Section 381.9 Aeronautics and... SPECIAL EVENT TOURS § 381.9 Sales. (a) Except as provided in paragraph (b) of this section: (1) No... booking must be returned within 3 business days. (2) Upon acceptance of the money for a sale, the...

  18. 24 CFR 290.13 - Negotiated sales.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Negotiated sales. 290.13 Section... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.13 Negotiated sales. When HUD conducts a negotiated...

  19. 7 CFR 1955.148 - Auction sales.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 14 2012-01-01 2012-01-01 false Auction sales. 1955.148 Section 1955.148 Agriculture... REGULATIONS (CONTINUED) PROPERTY MANAGEMENT Disposal of Inventory Property General § 1955.148 Auction sales. This section provides guidance on the sale of all inventory property by auction, except FSA...

  20. 36 CFR 228.58 - Competitive sales.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Competitive sales. 228.58... Disposal of Mineral Materials Types and Methods of Disposal § 228.58 Competitive sales. (a) Invitation for bid. Sales must be conducted as described below after inviting competitive bids through...

  1. 36 CFR 228.58 - Competitive sales.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Competitive sales. 228.58... Disposal of Mineral Materials Types and Methods of Disposal § 228.58 Competitive sales. (a) Invitation for bid. Sales must be conducted as described below after inviting competitive bids through...

  2. 21 CFR 203.20 - Sales restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 4 2012-04-01 2012-04-01 false Sales restrictions. 203.20 Section 203.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL PRESCRIPTION DRUG MARKETING Sales Restrictions § 203.20 Sales restrictions. Except as provided in § 203.22...

  3. 24 CFR 290.13 - Negotiated sales.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Negotiated sales. 290.13 Section... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.13 Negotiated sales. When HUD conducts a negotiated...

  4. 43 CFR 5452.1 - Cash sales.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Cash sales. 5452.1 Section 5452.1 Public... OF THE INTERIOR FOREST MANAGEMENT (5000) AWARD OF CONTRACT Method of Payment § 5452.1 Cash sales. For sales under $500 the full amount shall be paid prior to or at the time the authorized officer signs...

  5. 15 CFR 904.505 - Summary sale.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 3 2013-01-01 2013-01-01 false Summary sale. 904.505 Section 904.505... and Forfeiture Procedures § 904.505 Summary sale. (a) In view of the perishable nature of fish, any... the sale to a person authorized to enforce a statute administered by NOAA immediately upon request...

  6. 21 CFR 203.20 - Sales restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 4 2013-04-01 2013-04-01 false Sales restrictions. 203.20 Section 203.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL PRESCRIPTION DRUG MARKETING Sales Restrictions § 203.20 Sales restrictions. Except as provided in § 203.22...

  7. 43 CFR 5422.1 - Cruise sales.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Cruise sales. 5422.1 Section 5422.1 Public... OF THE INTERIOR FOREST MANAGEMENT (5000) PREPARATION FOR SALE Volume Measurements § 5422.1 Cruise sales. As the general practice, the Bureau will sell timber on a tree cruise basis....

  8. 21 CFR 203.20 - Sales restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 4 2011-04-01 2011-04-01 false Sales restrictions. 203.20 Section 203.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL PRESCRIPTION DRUG MARKETING Sales Restrictions § 203.20 Sales restrictions. Except as provided in § 203.22...

  9. 15 CFR 904.505 - Summary sale.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Summary sale. 904.505 Section 904.505... and Forfeiture Procedures § 904.505 Summary sale. (a) In view of the perishable nature of fish, any... the sale to a person authorized to enforce a statute administered by NOAA immediately upon request...

  10. 43 CFR 5422.1 - Cruise sales.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Cruise sales. 5422.1 Section 5422.1 Public... OF THE INTERIOR FOREST MANAGEMENT (5000) PREPARATION FOR SALE Volume Measurements § 5422.1 Cruise sales. As the general practice, the Bureau will sell timber on a tree cruise basis....

  11. 36 CFR 228.58 - Competitive sales.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Competitive sales. 228.58... Disposal of Mineral Materials Types and Methods of Disposal § 228.58 Competitive sales. (a) Invitation for bid. Sales must be conducted as described below after inviting competitive bids through...

  12. 21 CFR 203.20 - Sales restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 4 2014-04-01 2014-04-01 false Sales restrictions. 203.20 Section 203.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL PRESCRIPTION DRUG MARKETING Sales Restrictions § 203.20 Sales restrictions. Except as provided in § 203.22...

  13. 36 CFR 228.58 - Competitive sales.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Competitive sales. 228.58... Disposal of Mineral Materials Types and Methods of Disposal § 228.58 Competitive sales. (a) Invitation for bid. Sales must be conducted as described below after inviting competitive bids through...

  14. 14 CFR 381.9 - Sales.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Sales. 381.9 Section 381.9 Aeronautics and... SPECIAL EVENT TOURS § 381.9 Sales. (a) Except as provided in paragraph (b) of this section: (1) No... booking must be returned within 3 business days. (2) Upon acceptance of the money for a sale, the...

  15. 15 CFR 904.505 - Summary sale.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 3 2012-01-01 2012-01-01 false Summary sale. 904.505 Section 904.505... and Forfeiture Procedures § 904.505 Summary sale. (a) In view of the perishable nature of fish, any... the sale to a person authorized to enforce a statute administered by NOAA immediately upon request...

  16. 43 CFR 5452.1 - Cash sales.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Cash sales. 5452.1 Section 5452.1 Public... OF THE INTERIOR FOREST MANAGEMENT (5000) AWARD OF CONTRACT Method of Payment § 5452.1 Cash sales. For sales under $500 the full amount shall be paid prior to or at the time the authorized officer signs...

  17. 43 CFR 5452.1 - Cash sales.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Cash sales. 5452.1 Section 5452.1 Public... OF THE INTERIOR FOREST MANAGEMENT (5000) AWARD OF CONTRACT Method of Payment § 5452.1 Cash sales. For sales under $500 the full amount shall be paid prior to or at the time the authorized officer signs...

  18. 24 CFR 290.13 - Negotiated sales.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Negotiated sales. 290.13 Section... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.13 Negotiated sales. When HUD conducts a negotiated...

  19. 43 CFR 5452.1 - Cash sales.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Cash sales. 5452.1 Section 5452.1 Public... OF THE INTERIOR FOREST MANAGEMENT (5000) AWARD OF CONTRACT Method of Payment § 5452.1 Cash sales. For sales under $500 the full amount shall be paid prior to or at the time the authorized officer signs...

  20. 43 CFR 5422.1 - Cruise sales.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Cruise sales. 5422.1 Section 5422.1 Public... OF THE INTERIOR FOREST MANAGEMENT (5000) PREPARATION FOR SALE Volume Measurements § 5422.1 Cruise sales. As the general practice, the Bureau will sell timber on a tree cruise basis....

  1. 14 CFR 381.9 - Sales.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Sales. 381.9 Section 381.9 Aeronautics and... SPECIAL EVENT TOURS § 381.9 Sales. (a) Except as provided in paragraph (b) of this section: (1) No... booking must be returned within 3 business days. (2) Upon acceptance of the money for a sale, the...

  2. 7 CFR 929.13 - Sales history.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Sales history. 929.13 Section 929.13 Agriculture... LONG ISLAND IN THE STATE OF NEW YORK Order Regulating Handling Definitions § 929.13 Sales history. Sales history means the number of barrels of cranberries established for a grower by the...

  3. 36 CFR 228.58 - Competitive sales.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Disposal of Mineral Materials Types and Methods of Disposal § 228.58 Competitive sales. (a) Invitation for... over 25,000 cubic yards. Mineral material sales offered by competitive bidding and which exceed 25,000...) Advertising smaller sales. Advertisement of mineral materials amounting to 25,000 cubic yards in volume...

  4. Inferences about Action Engage Action Systems

    ERIC Educational Resources Information Center

    Taylor, Lawrence J.; Lev-Ari, Shiri; Zwaan, Rolf A.

    2008-01-01

    Verbal descriptions of actions activate compatible motor responses [Glenberg, A. M., & Kaschak, M. P. (2002). Grounding language in action. "Psychonomic Bulletin & Review, 9", 558-565]. Previous studies have found that the motor processes for manual rotation are engaged in a direction-specific manner when a verb disambiguates the direction of…

  5. Tracking Cholera through Surveillance of Oral Rehydration Solution Sales at Pharmacies: Insights from Urban Bangladesh

    PubMed Central

    Azman, Andrew S.; Lessler, Justin; Satter, Syed Moinuddin; Mckay, Michael V.; Khan, Azharul; Ahmed, Dilruba; Gurley, Emily S.

    2015-01-01

    Background In Bangladesh, pharmacy-purchased oral rehydration solution (ORS) is often used to treat diarrhea, including cholera. Over-the-counter sales have been used for epidemiologic surveillance in the past, but rarely, if ever, in low-income countries. With few early indicators for cholera outbreaks in endemic areas, diarrhea-related product sales may serve as a useful surveillance tool. Methodology/Principal Findings We tracked daily ORS sales at 50 pharmacies and drug-sellers in an urban Bangladesh community of 129,000 for 6-months while simultaneously conducting surveillance for diarrhea hospitalizations among residents. We developed a mobile phone based system to track the sales of ORS and deployed it in parallel with a paper-based system. Our objectives were to determine if the mobile phone system was practical and acceptable to pharmacists and drug sellers, whether data were reported accurately compared to a paper-based system, and whether ORS sales were associated with future incidence of cholera hospitalizations within the community. We recorded 47,215 customers purchasing ORS, and 315 hospitalized diarrhea cases, 22% of which had culture-confirmed cholera. ORS sales and diarrhea incidence were independently associated with the mean daily temperature; therefore both unadjusted and adjusted models were explored. Through unadjusted cross-correlation statistics and generalized linear models, we found increases in ORS sales were significantly associated with increases in hospitalized diarrhea cases up to 9-days later and hospitalized cholera cases up to one day later. After adjusting for mean daily temperature, ORS was significantly associated with hospitalized diarrhea two days later and hospitalized cholera one day later. Conclusions/Significance Pharmacy sales data may serve as a feasible and useful surveillance tool. Given the relatively short lagged correlation between ORS sales and diarrhea, rapid and accurate sales data are key. More work is needed

  6. Evidence of direct thermal action upon the vestibular receptors in the caloric test. A re-interpretation of the data of Coats and Smith.

    PubMed

    Hood, J D

    1989-01-01

    Although Bárány's convection theory has gained wide acceptance, there is strong evidence that the caloric response may include a component resulting from direct thermal stimulation of the vestibular end organs. It is argued on theoretical grounds that important new information could be obtained from a precise determination of the neutral head positions at which caloric irrigation fails to elicit a response. Although experimental studies using a bracketing procedure proved unsuccessful for this purpose, a re-examination of the extensive studies of Coats and Smith revealed that this information was already available. Reinterpreted in this way, their data clearly indicate that the hot and cold components resulting from direct thermal action equate to 42% and 34% respectively of the responses obtained in the planes of maximum reactivity. This is of sufficient magnitude to account for the anomalous findings in Spacelab I. Because of non-linearity in the relationship between neural discharge evoked by caloric irrigation and nystagmus magnitude, this component may be significantly less in the conventional caloric position. For this and other reasons there would seem to be no good reason to re-evaluate the clinical reliability of the caloric test.

  7. Fuel oil and kerosene sales 1997

    SciTech Connect

    1998-08-01

    The Fuel Oil and Kerosene Sales 1997 report provides information, illustrations and state-level statistical data on end-use sales of kerosene; No. 1, No. 2, and No. 4 distillate fuel oil; and residual fuel oil. State-level kerosene sales include volumes for residential, commercial, industrial, farm, and all other uses. State-level distillate sales include volumes for residential, commercial, industrial, oil company, railroad, vessel bunkering, military, electric utility, farm, on-highway, off highway construction, and other uses. State-level residual fuel sales include volumes for commercial, industrial, oil company, vessel bunkering, military, electric utility, and other uses. 24 tabs.

  8. Trypsin action on the growth of Sendai virus in tissue culture cells. I. Restoration of the infectivity for L cells by direct action of tyrpsin on L cell-borne Sendai virus.

    PubMed

    Homma, M

    1971-11-01

    Sendai virus grown in fertile eggs (egg Sendai) infects L cells in which the synthesis of L Sendai (grown in L cells) occurs by the one-step mechanism. L Sendai is not infectious for L cells when tested by the tube titration method although it is infectious for chick embryos. When L cells infected with egg Sendai were dispersed by trypsin and plated on a monolayer culture of L cells, the viral agents spread to the adjacent recipient cells in which the synthesis of L Sendai occurred. The newly infected L cells became infectious for L cells again by trypsin treatment. Kinetic experiments suggested that the target of trypsin is the mature virus, of L Sendai nature, just budding from the L-cell surface. By using an immunofluorescent cell-counting technique, recovery of the infectivity of L Sendai for L cells due to a direct enzymatic action of trypsin was demonstrated. Under the optimal condition, the infectivity increased 1,000-fold for L cells and 10-fold for chick embryos, and both the titers could favorably be compared. No increasing effect of trypsin was observed on the infectivity of egg Sendai. Density centrifugation studies revealed a difference between egg Sendai and L Sendai in the density. Trypsin treatment which induced the maximal enhancement of L Sendai infectivity did not affect both the densities, showing that variations of Sendai virus in the infectivity for L cells and in the density are independent types of host-controlled modification.

  9. Evaluation of a regional community action intervention in New Zealand to improve age checks for young people purchasing alcohol.

    PubMed

    Huckle, Taisia; Conway, Kim; Casswell, Sally; Pledger, Megan

    2005-06-01

    This paper describes the evaluation of a regional community action intervention to reduce access to alcohol from off-license premises by minors. The intervention focussed on: (1) monitoring alcohol sales made without age identification from off-licenses; (2) utilizing data on alcohol sales for media advocacy and direct contact with alcohol retailers and (3) working with key enforcement staff to encourage increased monitoring and enforcement of minimum purchase age legislation for off-licenses. Evaluation of this intervention used a case study design. Purchase survey data was obtained before and after intervention. Media items were monitored and included pre- and post-intervention phases. Interviews, with key enforcement staff, and document review were undertaken post-intervention. Purchase survey data showed a significant decrease (p < 0.05) in sales of alcohol made to young people without age identification pre- and post-intervention. Pre-intervention: 60% of visits resulted in a sale made without age identification; post-intervention this proportion was 46%. Principal component analysis of newsprint media indicated increased coverage of items advocating improved age checking for off-licenses following intervention. Interview data and document review indicate that some enforcement staff in the region implemented increased enforcement strategies including, controlled purchase operations and increased visits to off-licenses due to the intervention. Evaluation findings indicate that collaborative and intersectoral community action interventions implemented regionally can be effective in redirecting resources to achieve preventive outcomes at a population level.

  10. Evaluation of a regional community action intervention in New Zealand to improve age checks for young people purchasing alcohol.

    PubMed

    Huckle, Taisia; Conway, Kim; Casswell, Sally; Pledger, Megan

    2005-06-01

    This paper describes the evaluation of a regional community action intervention to reduce access to alcohol from off-license premises by minors. The intervention focussed on: (1) monitoring alcohol sales made without age identification from off-licenses; (2) utilizing data on alcohol sales for media advocacy and direct contact with alcohol retailers and (3) working with key enforcement staff to encourage increased monitoring and enforcement of minimum purchase age legislation for off-licenses. Evaluation of this intervention used a case study design. Purchase survey data was obtained before and after intervention. Media items were monitored and included pre- and post-intervention phases. Interviews, with key enforcement staff, and document review were undertaken post-intervention. Purchase survey data showed a significant decrease (p < 0.05) in sales of alcohol made to young people without age identification pre- and post-intervention. Pre-intervention: 60% of visits resulted in a sale made without age identification; post-intervention this proportion was 46%. Principal component analysis of newsprint media indicated increased coverage of items advocating improved age checking for off-licenses following intervention. Interview data and document review indicate that some enforcement staff in the region implemented increased enforcement strategies including, controlled purchase operations and increased visits to off-licenses due to the intervention. Evaluation findings indicate that collaborative and intersectoral community action interventions implemented regionally can be effective in redirecting resources to achieve preventive outcomes at a population level. PMID:15722363

  11. iES - An Intelligent Electronic Sales Platform

    SciTech Connect

    Stanton, V L; Korbe III, W; Gao, J G

    2003-10-02

    Current e-commerce systems support online shopping based on electronic product catalogs. The major issues associated with catalog-based commerce systems are: difficulty in distinguishing one retailer from another, complex navigation with confusing links, and a lack of personalized service. This paper reports an intelligent solution to address these issues. Our solution will provide a more personalized sales experience through the use of a transaction-based knowledge model that includes both the rules used for reasoning as well as the corresponding actions. Based on this solution, we have developed an intelligent electronic sales platform that is supported by a framework which provides the desired personalization as well as extensibility and customization capabilities. This paper reports our design and development of this system and application examples.

  12. Conscious Action/Zombie Action

    PubMed Central

    Shepherd, Joshua

    2015-01-01

    Abstract I argue that the neural realizers of experiences of trying (that is, experiences of directing effort towards the satisfaction of an intention) are not distinct from the neural realizers of actual trying (that is, actual effort directed towards the satisfaction of an intention). I then ask how experiences of trying might relate to the perceptual experiences one has while acting. First, I assess recent zombie action arguments regarding conscious visual experience, and I argue that contrary to what some have claimed, conscious visual experience plays a causal role for action control in some circumstances. Second, I propose a multimodal account of the experience of acting. According to this account, the experience of acting is (at the very least) a temporally extended, co‐conscious collection of agentive and perceptual experiences, functionally integrated and structured both by multimodal perceptual processing as well as by what an agent is, at the time, trying to do. PMID:27667859

  13. Conscious Action/Zombie Action

    PubMed Central

    Shepherd, Joshua

    2015-01-01

    Abstract I argue that the neural realizers of experiences of trying (that is, experiences of directing effort towards the satisfaction of an intention) are not distinct from the neural realizers of actual trying (that is, actual effort directed towards the satisfaction of an intention). I then ask how experiences of trying might relate to the perceptual experiences one has while acting. First, I assess recent zombie action arguments regarding conscious visual experience, and I argue that contrary to what some have claimed, conscious visual experience plays a causal role for action control in some circumstances. Second, I propose a multimodal account of the experience of acting. According to this account, the experience of acting is (at the very least) a temporally extended, co‐conscious collection of agentive and perceptual experiences, functionally integrated and structured both by multimodal perceptual processing as well as by what an agent is, at the time, trying to do.

  14. Numerical Study of Convection in the Directional Solidification of a Binary Alloy Driven by the Combined Action of Buoyancy, Surface Tension, and Electromagnetic Forces

    NASA Astrophysics Data System (ADS)

    Sampath, Rajiv; Zabaras, Nicholas

    2001-04-01

    Directional solidification of a dilute electrically conducting binary alloy driven by the combined action of buoyancy, surface-tension, and electromagnetic forces is considered. A numerical methodology using a moving finite element technique is proposed for the simulation of the above phase change process. The melt is modeled as a Boussinesq fluid and the transient Navier-Stokes equations are solved simultaneously with the transient heat and solute transport equations. The location of the advancing solid-liquid interface is numerically determined using an energy preserving weak form of the Stefan condition. The standard SUPG/PSPG method for the simulation of incompressible fluid flow is here extended to flows driven by the combination of buoyancy, surface tension, and electromagnetic forces. A reference problem of directional solidification of a dilute germanium alloy in a horizontal open-boat configuration is considered. The relative influence of thermocapillary convection and buoyancy-driven convection on the solidification process is investigated by varying the Bond number. Thermocapillary convection is shown to have a significant influence on various solidification parameters, such as the shape of the solid-liquid interface and the solute segregation, especially under low gravity conditions. The influence of an external magnetic field on the reference solidification problem is investigated both in a normal and a reduced gravity environment. It is demonstrated that the application of an appropriate strong magnetic field significantly damps the melt flow and improves the solute segregation pattern. The relative influence of an external magnetic field on the solidification process is also studied by independently varying the orientation and magnitude of the applied magnetic field.

  15. Electro-optically responsive composites of gold nanospheres in 5CB liquid crystal under direct current and alternating current joint action

    SciTech Connect

    Hadjichristov, Georgi B.; Marinov, Yordan G.; Petrov, Alexander G.; Bruno, Emanuela; Marino, Lucia; Scaramuzza, Nicola

    2014-02-28

    Direct current (DC) electro-optical (EO) control of transmitted laser beam intensity based on EO controlled coherent light scattering and diffraction by stationary longitudinal texture pattern (LTP) is achieved in planar-oriented cells with a composite mixture of polymer-coated gold spherical nanoparticles (Au-NPs) with a mean diameter of about 12 nm and the room-temperature nematic pentylcyanobiphenyl (5CB). At relatively low DC voltage of about 5 V, the effective scattering/diffraction by Au-NPs/5CB composites leads to a spatial spreading of transmitted coherent light from a low-power continuous wave laser beam, resulting in a drastic reduction of its local intensity. The effect is polarization dependent and is strongest when the polarization of the input laser beam is along the LTP. The EO response of Au-NPs/5CB mixtures is studied under DC and alternating current (AC) joint action with the aim of the potential use of these composite materials as EO controlled diffusers. The specific V-shaped sharp dip in the DC voltage-dependent coherent light transmittance of Au-NPs/5CB planar films, as well as the possibility for erasing the scattering/diffractive LTP in the films by joint low AC voltage, can be useful for EO applications in the field of process control and for detection of weak dynamic electric fields.

  16. Electro-optically responsive composites of gold nanospheres in 5CB liquid crystal under direct current and alternating current joint action

    NASA Astrophysics Data System (ADS)

    Hadjichristov, Georgi B.; Marinov, Yordan G.; Petrov, Alexander G.; Bruno, Emanuela; Marino, Lucia; Scaramuzza, Nicola

    2014-02-01

    Direct current (DC) electro-optical (EO) control of transmitted laser beam intensity based on EO controlled coherent light scattering and diffraction by stationary longitudinal texture pattern (LTP) is achieved in planar-oriented cells with a composite mixture of polymer-coated gold spherical nanoparticles (Au-NPs) with a mean diameter of about 12 nm and the room-temperature nematic pentylcyanobiphenyl (5CB). At relatively low DC voltage of about 5 V, the effective scattering/diffraction by Au-NPs/5CB composites leads to a spatial spreading of transmitted coherent light from a low-power continuous wave laser beam, resulting in a drastic reduction of its local intensity. The effect is polarization dependent and is strongest when the polarization of the input laser beam is along the LTP. The EO response of Au-NPs/5CB mixtures is studied under DC and alternating current (AC) joint action with the aim of the potential use of these composite materials as EO controlled diffusers. The specific V-shaped sharp dip in the DC voltage-dependent coherent light transmittance of Au-NPs/5CB planar films, as well as the possibility for erasing the scattering/diffractive LTP in the films by joint low AC voltage, can be useful for EO applications in the field of process control and for detection of weak dynamic electric fields.

  17. Further steps toward direct magnetic resonance (MR) imaging detection of neural action currents: optimization of MR sensitivity to transient and weak currents in a conductor.

    PubMed

    Pell, Gaby S; Abbott, David F; Fleming, Steven W; Prichard, James W; Jackson, Graeme D

    2006-05-01

    The characteristics of an MRI technique that could be used for direct detection of neuronal activity are investigated. It was shown that magnitude imaging using echo planar imaging can detect transient local currents. The sensitivity of this method was thoroughly investigated. A partial k-space EPI acquisition with homodyne reconstruction was found to increase the signal change. A unique sensitivity to the position of the current pulse within the imaging sequence was demonstrated with the greatest signal change occurring when the current pulse coincides with the acquisition of the center lines of k-space. The signal change was shown to be highly sensitive to the spatial position of the current conductor relative to the voxel. Furthermore, with the use of optimization of spatial and temporal placement of the current pulse, the level of signal change obtained at this lower limit of current detectability was considerably magnified. It was possible to detect a current of 1.7 microA applied for 20 ms with an imaging time of 1.8 min. The level of sensitivity observed in our study brings us closer to that theoretically required for the detection of action currents in nerves.

  18. Action in Development

    ERIC Educational Resources Information Center

    von Hofsten, Claes

    2007-01-01

    It is argued that cognitive development has to be understood in the functional perspective provided by actions. Actions reflect all aspects of cognitive development including the motives of the child, the problems to be solved, and the constraints and possibilities of the child's body and sensorimotor system. Actions are directed into the future…

  19. Fuel oil and kerosene sales 1996

    SciTech Connect

    1997-08-01

    The Fuel Oil and Kerosene Sales 1996 report provides information, illustrations and State-level statistical data on end-use sales of kerosene; No. 1, No. 2, and No. 4 distillate fuel oil; and residual fuel oil. State-level kerosene sales include volumes for residential, commercial, industrial, farm, and all other uses. State-level distillate sales include volumes for residential, commercial, industrial, oil company, railroad, vessel bunkering, military, electric utility, farm, on-highway, off highway construction, and other uses. State-level residual fuel sales include volumes for commercial, industrial, oil company, vessel bunkering, military, electric utility, and other uses. The Petroleum Marketing Division, Office of Oil and Gas, Energy Information Administration ensures the accuracy, quality, and confidentiality of the published data in the Fuel Oil and Kerosene Sales 1996. 24 tabs.

  20. 27 CFR 6.71 - Quota sales.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Quota sales. 6.71 Section 6.71 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS âTIED-HOUSEâ Unlawful Inducements Quota Sales § 6.71 Quota sales. The act by an industry member of requiring a retailer to...

  1. 27 CFR 6.71 - Quota sales.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Quota sales. 6.71 Section 6.71 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL âTIED-HOUSEâ Unlawful Inducements Quota Sales § 6.71 Quota sales. The act by an industry member of requiring a retailer to...

  2. 27 CFR 6.71 - Quota sales.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Quota sales. 6.71 Section 6.71 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL âTIED-HOUSEâ Unlawful Inducements Quota Sales § 6.71 Quota sales. The act by an industry member of requiring a retailer to...

  3. 27 CFR 6.71 - Quota sales.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Quota sales. 6.71 Section 6.71 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS âTIED-HOUSEâ Unlawful Inducements Quota Sales § 6.71 Quota sales. The act by an industry member of requiring a retailer to...

  4. 27 CFR 6.71 - Quota sales.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Quota sales. 6.71 Section 6.71 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS âTIED-HOUSEâ Unlawful Inducements Quota Sales § 6.71 Quota sales. The act by an industry member of requiring a retailer to...

  5. 76 FR 21033 - International Business Machines (IBM), Sales and Distribution Business Unit, Global Sales...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-14

    ... on November 17, 2010 (75 FR 70296). The workers supply computer software development and maintenance... Employment and Training Administration International Business Machines (IBM), Sales and Distribution Business... workers of International Business Machines (IBM), Sales and Distribution Business Unit, Global...

  6. 7 CFR 1955.118 - Processing cash sales or MFH credit sales on NP terms.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Inventory Property Rural Housing (rh) Real Property § 1955.118 Processing cash sales or MFH credit sales on... be amortized using a 30-year factor with payment in full (balloon payment) due not later than...

  7. 7 CFR 1955.118 - Processing cash sales or MFH credit sales on NP terms.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Inventory Property Rural Housing (rh) Real Property § 1955.118 Processing cash sales or MFH credit sales on... be amortized using a 30-year factor with payment in full (balloon payment) due not later than...

  8. 7 CFR 1955.118 - Processing cash sales or MFH credit sales on NP terms.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Inventory Property Rural Housing (rh) Real Property § 1955.118 Processing cash sales or MFH credit sales on... be amortized using a 30-year factor with payment in full (balloon payment) due not later than...

  9. 7 CFR 1955.118 - Processing cash sales or MFH credit sales on NP terms.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Inventory Property Rural Housing (rh) Real Property § 1955.118 Processing cash sales or MFH credit sales on... be amortized using a 30-year factor with payment in full (balloon payment) due not later than...

  10. 7 CFR 1955.118 - Processing cash sales or MFH credit sales on NP terms.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Inventory Property Rural Housing (rh) Real Property § 1955.118 Processing cash sales or MFH credit sales on... be amortized using a 30-year factor with payment in full (balloon payment) due not later than...

  11. 10 CFR 625.3 - Standard sales provisions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... DEPARTMENT OF ENERGY (CONTINUED) SALES REGULATION PRICE COMPETITIVE SALE OF STRATEGIC PETROLEUM RESERVE PETROLEUM § 625.3 Standard sales provisions. (a) Contents. The Standards Sales Provisions shall contain contract clauses which may be applicable to price competitive sales of SPR petroleum, including terms...

  12. 10 CFR 625.3 - Standard sales provisions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DEPARTMENT OF ENERGY (CONTINUED) SALES REGULATION PRICE COMPETITIVE SALE OF STRATEGIC PETROLEUM RESERVE PETROLEUM § 625.3 Standard sales provisions. (a) Contents. The Standards Sales Provisions shall contain contract clauses which may be applicable to price competitive sales of SPR petroleum, including terms...

  13. 10 CFR 625.3 - Standard sales provisions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DEPARTMENT OF ENERGY (CONTINUED) SALES REGULATION PRICE COMPETITIVE SALE OF STRATEGIC PETROLEUM RESERVE PETROLEUM § 625.3 Standard sales provisions. (a) Contents. The Standards Sales Provisions shall contain contract clauses which may be applicable to price competitive sales of SPR petroleum, including terms...

  14. 10 CFR 625.3 - Standard sales provisions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DEPARTMENT OF ENERGY (CONTINUED) SALES REGULATION PRICE COMPETITIVE SALE OF STRATEGIC PETROLEUM RESERVE PETROLEUM § 625.3 Standard sales provisions. (a) Contents. The Standards Sales Provisions shall contain contract clauses which may be applicable to price competitive sales of SPR petroleum, including terms...

  15. 10 CFR 625.3 - Standard sales provisions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... DEPARTMENT OF ENERGY (CONTINUED) SALES REGULATION PRICE COMPETITIVE SALE OF STRATEGIC PETROLEUM RESERVE PETROLEUM § 625.3 Standard sales provisions. (a) Contents. The Standards Sales Provisions shall contain contract clauses which may be applicable to price competitive sales of SPR petroleum, including terms...

  16. 29 CFR 541.501 - Making sales or obtaining orders.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Making sales or obtaining orders. 541.501 Section 541.501... SALES EMPLOYEES Outside Sales Employees § 541.501 Making sales or obtaining orders. (a) Section 541.500 requires that the employee be engaged in: (1) Making sales within the meaning of section 3(k) of the...

  17. 29 CFR 541.501 - Making sales or obtaining orders.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Making sales or obtaining orders. 541.501 Section 541.501... SALES EMPLOYEES Outside Sales Employees § 541.501 Making sales or obtaining orders. (a) Section 541.500 requires that the employee be engaged in: (1) Making sales within the meaning of section 3(k) of the...

  18. 29 CFR 541.501 - Making sales or obtaining orders.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Making sales or obtaining orders. 541.501 Section 541.501... SALES EMPLOYEES Outside Sales Employees § 541.501 Making sales or obtaining orders. (a) Section 541.500 requires that the employee be engaged in: (1) Making sales within the meaning of section 3(k) of the...

  19. 29 CFR 541.501 - Making sales or obtaining orders.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Making sales or obtaining orders. 541.501 Section 541.501... SALES EMPLOYEES Outside Sales Employees § 541.501 Making sales or obtaining orders. (a) Section 541.500 requires that the employee be engaged in: (1) Making sales within the meaning of section 3(k) of the...

  20. 29 CFR 541.501 - Making sales or obtaining orders.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Making sales or obtaining orders. 541.501 Section 541.501... SALES EMPLOYEES Outside Sales Employees § 541.501 Making sales or obtaining orders. (a) Section 541.500 requires that the employee be engaged in: (1) Making sales within the meaning of section 3(k) of the...