Science.gov

Sample records for action establishes class

  1. 75 FR 42 - Establishment of Class E Airspace; Spencer, WV

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-04

    ... October 19, 2009 (74 FR 53407), Docket No. FAA- 2009-0602; Airspace Docket No. 09-AEA-13. The FAA uses the... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Spencer, WV AGENCY... that establishes Class E Airspace at Spencer, WV. This action enhances the safety and...

  2. Defendants challenge class action certification.

    PubMed

    Dubin, C S; Wadleigh, J

    1995-04-01

    The National Hemophilia Foundation (NHF) and the manufacturers of Anti-Hemophilia Factor Concentrates (AHF) are being sued in a class action case for ignoring and downplaying risks of HIV infection from AHF in order to enhance their financial gain. The defendants in the case, however, have challenged the class action certification. Their Petition for a Writ of Mandamus argues that a class action lawsuit is not an appropriate legal vehicle for this type of case because, among other reasons, it will place an entire industry's survival in the hands of a single jury decision. The two primary challenges to certification by the petition are that 1) it would complicate hemophilia/AIDS litigation and not simplify it, and 2) there is no common definition of negligence throughout state law. With certification in question, it is conceivable, according to attorney David Shrager, "that hundreds or even thousands of additional claims will now be filed in state and Federal courts throughout the country." Essentially, the defense against the Writ argues that the defendants knew in the 1960s of the high risk from known and new viruses in the plasma pools, that they had a duty to reduce such risk, and that they not only failed to withdraw their products from the market, they downplayed the harm done to persons who used contaminated AHF by making misleading statements. The class action trial is scheduled to begin October 2, 1995. PMID:11362336

  3. 76 FR 36285 - Establishment of Class E Airspace; Brunswick, ME

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-22

    ... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR...: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action establishes Class E... Approach Procedures developed for Brunswick Executive Airport. This enhances the safety and...

  4. Class Action Suits against Public Schools.

    ERIC Educational Resources Information Center

    Mesibov, Laurie

    1984-01-01

    If a suit is brought as a class action, either plaintiff or defendant may move to uphold or challenge class certification. If neither does so, the court decides whether the action may be maintained as a class suit. Prerequisites for class certification from Rule 23 (Federal Rules of Civil Procedure) are explained. (TE)

  5. 75 FR 43815 - Amendment of Class E Airspace; Clemson, SC and Establishment of Class E Airspace: Pickens, SC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-27

    ... amend Class E airspace at Clemson, SC and establish Class E airspace at Pickens, SC (75 FR 13697) Docket... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Clemson, SC and Establishment of Class E Airspace: Pickens, SC AGENCY: Federal Aviation Administration (FAA), DOT. ACTION:...

  6. 77 FR 22190 - Amendment of Class E Airspace; Columbia, SC, and Establishment of Class E Airspace; Pelion, SC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Columbia, SC, and Establishment of Class E Airspace; Pelion, SC AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E Airspace at Columbia, SC, by removing Corporate Airport...

  7. 78 FR 33015 - Proposed Amendment of Class D Airspace; Waco, TX, and Establishment of Class D Airspace; Waco...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-03

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Amendment of Class D Airspace; Waco, TX, and Establishment of Class D Airspace; Waco, TSTC-Waco Airport, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM). SUMMARY: This action proposes to amend Class...

  8. 16 CFR 1025.18 - Class actions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... parties on behalf of all respondents if: (1) The class is so numerous or geographically dispersed that..., and the difficulties likely to be encountered in the management of a class action, as well as...

  9. 16 CFR 1025.18 - Class actions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... parties on behalf of all respondents if: (1) The class is so numerous or geographically dispersed that..., and the difficulties likely to be encountered in the management of a class action, as well as...

  10. 16 CFR 1025.18 - Class actions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... parties on behalf of all respondents if: (1) The class is so numerous or geographically dispersed that..., and the difficulties likely to be encountered in the management of a class action, as well as...

  11. 16 CFR 1025.18 - Class actions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... parties on behalf of all respondents if: (1) The class is so numerous or geographically dispersed that..., and the difficulties likely to be encountered in the management of a class action, as well as...

  12. 16 CFR 1025.18 - Class actions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... parties on behalf of all respondents if: (1) The class is so numerous or geographically dispersed that..., and the difficulties likely to be encountered in the management of a class action, as well as...

  13. 78 FR 73752 - Proposed Establishment of Class E Airspace; Mansfield, OH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-09

    ...: This action proposes to establish Class E airspace at Mansfield, OH. A Class E surface area is... CFR), Part 71 by establishing Class E airspace designated as a surface area within a 4.4-mile radius... 6002: Class E Airspace Designated as Surface Areas * * * * * AGL OH E2 Mansfield, OH Mansfield...

  14. 75 FR 13697 - Amendment of Class E Airspace; Clemson, SC and Establishment of Class E Airspace; Pickens, SC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Clemson, SC and Establishment of Class E Airspace; Pickens, SC AGENCY: Federal Aviation Administration (FAA), DOT. ACTION..., SC, to correct the airspace description and establish Class E airspace at Pickens, SC, to achieve...

  15. 75 FR 16335 - Establishment of Class E Airspace; Mount Pleasant, SC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Mount Pleasant, SC.... SUMMARY: This action establishes Class E airspace at Mount Pleasant, SC, to accommodate Standard... establishes Class E airspace at Mount Pleasant, SC, to provide controlled airspace extending upward from...

  16. 75 FR 57216 - Proposed Establishment of Class E Airspace; Bamberg, SC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-20

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Bamberg, SC...: This action proposes to establish Class E Airspace at Bamberg, SC, to accommodate the additional... Federal Regulations (14 CFR) part 71 to establish Class E airspace at Bamberg, SC to provide...

  17. 75 FR 52654 - Proposed Establishment of Class E Airspace; Bamberg, SC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-27

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Bamberg, SC...: This action proposes to establish Class E Airspace at Bamberg, SC, to accommodate the additional... Federal Regulations (14 CFR) part 71 to establish Class E airspace at Bamberg, SC to provide...

  18. Oil and gas: Oilfield class actions

    SciTech Connect

    McArthur, J.B.

    1997-06-01

    The use of class actions is getting alot of attention in the oilfield. Plaintiffs have filed class actions challenging two of the most rooted industry practices, oil posted prices and deregulated natural gas affiliate deduction and charges. The classes will include tens or hundreds of thousands of plaintiffs and may transform two of the industry`s most settled practices. The emotions surrounding the class action risk obscuring the fact that it is an old and oft-used tool in oilfield litigation. The class action {open_quotes}provides a means by which, where a large group of persons are interested in a matter, one or more may sue or be sued as representatives of the class without needing to join every member of the class.{close_quotes} The procedure avoids waste by combining scattered disputes, even if some injured might sue individually, and it enables plaintiffs who could not afford to sue to be represented anyway. The lawyers draw their fees from any recovery. Almost all oilpatch class actions are brought to resolve a {open_quotes}common question{close_quotes} under Federal Rules of Civil Procedure 23(b)(3) or state counterparts. The rule`s {open_quotes}opt-out{close_quotes} provisions give class actions a tremendous boost because members stay in unless they take steps to get out. This article discusses present and future class actions.

  19. 76 FR 36017 - Proposed Amendment of Class D and Class E Airspace and Establishment of Class E Airspace; Casper, WY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-21

    ... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The incorporation by... airport. This action also would establish Class E En Route Domestic airspace at the airport, to...

  20. 75 FR 65226 - Establishment of Class E Airspace; Bamberg, SC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-22

    ... Register a notice of proposed rulemaking to establish Class E airspace at Bamberg, SC (75 FR 52654) Docket... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Bamberg, SC AGENCY... establishes Class E airspace at Bamberg, SC. Lists of Subjects in 14 CFR Part 71 Airspace, Incorporation...

  1. Disability, disparate impact, and class actions.

    PubMed

    Stein, Michael Ashley; Waterstone, Michael E

    2006-12-01

    Following Title VII's enactment, group-based employment discrimination actions flourished due to disparate impact theory and the class action device. Courts recognized that subordination that defined a group's social identity was also sufficient legally to bind members together, even when relief had to be issued individually. Woven through these cases was a notion of panethnicity that united inherently unrelated groups into a common identity, for example, Asian Americans. Stringent judicial interpretation subsequently eroded both legal frameworks and it has become increasingly difficult to assert collective employment actions, even against discriminatory practices affecting an entire group. This deconstruction has immensely disadvantaged persons with disabilities. Under the Americans with Disabilities Act (ADA), individual employee claims to accommodate specific impairments, such as whether to install ramps or replace computer screens, have all but eclipsed a coherent theory of disability-based disparate impact law. Moreover, the class action device has been virtually nonexistent in disability discrimination employment cases. The absence of collective action has been especially harmful because the realm of the workplace is precisely where group-based remedies are needed most. Specifically, a crucial but overlooked issue in disability integration is the harder-to-reach embedded norms that require job and policy modifications. The Article argues that pandisability theory serves as an analogue to earlier notions of panethnicity and provides an equally compelling heuristic for determining class identity. It shows that pandisability undergirds ADA public service and public accommodation class actions in which individualized remedy assessments have been accepted as part of group-based challenges to social exclusion. The Article also demonstrates that this broader vision of collective action is consistent with the history underlying the class action device. Taking

  2. 75 FR 4270 - Establishment of Class E Airspace; Tompkinsville, KY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-27

    ... September 14, 2009 (74 FR 46890), Docket No. FAA-2009-0604; Airspace Docket No. 09-ASO-18. The FAA uses the... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Tompkinsville, KY AGENCY... September 14, 2009 that establishes Class E Airspace at Tompkinsville--Monroe County Airport,...

  3. 75 FR 4269 - Establishment of Class E Airspace; Lewisport, KY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-27

    ... September 14, 2009 (74 FR 46896), Docket No. FAA-2009-0706; Airspace Docket No. 09-ASO-26. The FAA uses the... TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Lewisport, KY... Register September 14, 2009 that establishes Class E Airspace at Hancock Co.--Ron Lewis Field,...

  4. 75 FR 4269 - Establishment of Class E Airspace; Clayton, GA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-27

    ... (74 FR 46893), Docket No. FAA-2009-0605; Airspace Docket 09-ASO-19. The FAA uses the direct final... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Clayton, GA AGENCY... September 14, 2009 that establishes Class E Airspace at Heaven's Landing Airport, Clayton, GA....

  5. 78 FR 67024 - Establishment of Class E Airspace; Glasgow, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ... Federal Aviation Administration 14 CFR Parts 71 Establishment of Class E Airspace; Glasgow, MT AGENCY... a final rule published in the Federal Register of September 30, 2013, that establishes Class E... aid, Glasgow, MT. A favorable comment from the National Business Aviation Association (NBAA)...

  6. 75 FR 4270 - Establishment of Class E Airspace; Saluda, SC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-27

    ... TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Saluda, SC... Register September 14, 2009 that establishes Class E Airspace at Saluda County Airport, Saluda, SC. DATES... (74 FR 46894), Docket No. FAA-2009-0603; Airspace Docket No. 09-ASO-16. The FAA uses the direct...

  7. 75 FR 20773 - Establishment of Class E Airspace; Jackson, AL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... final rule with a request for comments in the Federal Register on December 7, 2009 (74 FR 63973), Docket... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Jackson, AL AGENCY... December 7, 2009 that establishes Class E airspace at Jackson Muni, Jackson, AL. DATES: Effective...

  8. 23 CFR 771.115 - Classes of actions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false Classes of actions. 771.115 Section 771.115 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RIGHT-OF-WAY AND ENVIRONMENT ENVIRONMENTAL IMPACT AND RELATED PROCEDURES § 771.115 Classes of actions. There are three classes of actions which prescribe the level of documentation required...

  9. 23 CFR 771.115 - Classes of actions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Classes of actions. 771.115 Section 771.115 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RIGHT-OF-WAY AND ENVIRONMENT ENVIRONMENTAL IMPACT AND RELATED PROCEDURES § 771.115 Classes of actions. There are three classes of actions which prescribe the level of documentation required...

  10. 78 FR 46497 - Amendment of Class D and E Airspace, and Establishment of Class E Airspace; Oceana NAS, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-01

    ... Tower at Oceana NAS (Apollo Soucek Field) now operating on a part time basis. This action enhances the... also updates the geographic coordinates of Oceana NAS (Apollo Soucek Field) and NALF Fentress. DATES... airspace, and establish Class E airspace at Oceana Naval Air Station, (NAS), VA, (78 FR 21084)....

  11. 39 CFR 775.5 - Classes of actions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROCEDURES § 775.5 Classes of actions. (a) Actions which normally require an environment impact statement. None, however the Postal Service will prepare an EIS when necessary based on the factors identified in 40 CFR 1508.27. (b) Actions requiring an environmental assessment. Classes of actions that...

  12. 39 CFR 775.5 - Classes of actions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... PROCEDURES § 775.5 Classes of actions. (a) Actions which normally require an environment impact statement. None, however the Postal Service will prepare an EIS when necessary based on the factors identified in 40 CFR 1508.27. (b) Actions requiring an environmental assessment. Classes of actions that...

  13. 39 CFR 775.5 - Classes of actions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 CFR 1508.27. (b) Actions requiring an environmental assessment. Classes of actions that will... scientifically highly controversial; (6) Any action that may have highly uncertain or unknown risks on the...

  14. 39 CFR 775.5 - Classes of actions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 CFR 1508.27. (b) Actions requiring an environmental assessment. Classes of actions that will... scientifically highly controversial; (6) Any action that may have highly uncertain or unknown risks on the...

  15. 39 CFR 775.5 - Classes of actions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 CFR 1508.27. (b) Actions requiring an environmental assessment. Classes of actions that will... scientifically highly controversial; (6) Any action that may have highly uncertain or unknown risks on the...

  16. 75 FR 4269 - Establishment of Class E Airspace; Hertford, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-27

    ... (74 FR 46892), Docket No. FAA-2009-0705; Airspace Docket No. 09-ASO-25. The FAA uses the direct final... September 14, 2009 that establishes Class E Airspace at Harvey Point Defense Testing Activity, Hertford,...

  17. Merging separately established stimulus classes with outcome-specific reinforcement.

    PubMed

    Johnson, Cammarie; Meleshkevich, Olga; Dube, William V

    2014-01-01

    This study extended previous research on equivalence relations established with outcome-specific reinforcers to include the merger of separately established stimulus classes. Participants were four adults. Conditional discriminations AC and BC were trained first. Correct selections of C1 (C2, or C3) in the presence of A1 or B1 (A2 or B2, or A3 or B3) were followed by red (blue, or white) tokens; tokens were exchanged for value added to three participant-selected gift cards. Outcomes on equivalence tests for three-member classes ABC were positive. DF and EF were trained with the same reinforcing consequences, and tests were positive for three-member classes DEF. Results of class merger tests with combinations of stimuli from the ABC and DEF classes (AD, FB, etc.) were immediately positive for two participants, demonstrating six-member classes ABCDEF with reinforcers as nodes. Merger tests for a third participant were initially negative but became positive after brief exposure to unreinforced probe trials with reinforcers as comparison stimuli. Following class merger, tests for matching the reinforcers to samples and comparisons were also positive. Class-merger test results were negative for a fourth participant. The results provide the first demonstration of eight-member equivalence classes including two outcome-specific conditioned reinforcing stimuli.

  18. 78 FR 57789 - Establishment and Modification of Class E Airspace; Oakland, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-20

    .... The Director of the Federal Register approves this incorporation by reference action under 1 CFR Part... rulemaking (NPRM) to establish and modify controlled airspace at Oakland, CA (78 FR 40076). Interested..., 2013, which is incorporated by reference in 14 CFR Part 71.1. The Class E airspace designations...

  19. 75 FR 48551 - Establishment of Class E Airspace; Williamson, WV

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-11

    ... Register a notice of proposed rulemaking to establish Class E airspace at Williamson, WV (75 FR 26150... Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a Regulatory Evaluation..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The...

  20. 76 FR 45177 - Establishment of Class E Airspace; Nephi, UT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-28

    ... airspace at Nephi UT, to accommodate aircraft using new Area Navigation (RNAV) Global Positioning System... proposed rulemaking to establish Class E airspace at Nephi, UT (76 FR 28382). Interested parties were... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3)...

  1. 78 FR 67296 - Establishment of Class D Airspace; Mesquite, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ... Meacham Blvd., Fort Worth, TX 76137; telephone 817-321- 7716. SUPPLEMENTARY INFORMATION: History On August... establish Class D airspace for Mesquite Metro Airport, Mesquite, TX (78 FR 48842) Docket No. FAA-2012- 0580...) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February...

  2. 77 FR 45240 - Establishment of Class E Airspace; Arcadia, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-31

    ... establish Class E airspace at Oneonta, AL (77 FR 33685) Docket No. FAA-2012-0365. Interested parties were..., 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by... rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does...

  3. 78 FR 25384 - Establishment of Class E Airspace; Immokalee, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-01

    ... establish Class E airspace at Immokalee, FL (78 FR 6262) Docket No. FAA-2012-1051. Interested parties were...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44...

  4. 77 FR 60660 - Proposed Establishment Class E Airspace; Kasigluk, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-04

    ...: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment Class E Airspace; Kasigluk,...

  5. 78 FR 61179 - Establishment of Class E Airspace; Comanche, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-03

    ..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Comanche, TX...

  6. 76 FR 65944 - Establishment of Class E Airspace; Tatitlek, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-25

    ... to establish Class E airspace at Tatitlek, AK (76 FR 49388). Interested parties were invited to... U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71... not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February...

  7. 78 FR 38828 - Establishment of Class E Airspace; Captiva, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-28

    ... airspace at Upper Captiva Island Heliport, Captiva, FL, (78 FR 33967). Subsequent to publication, the FAA... Register of June 6, 2013, (78 FR 33967), FR Doc. 2013-13105, is delayed from June 27, 2013, to August 22... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Captiva, FL...

  8. 78 FR 72009 - Establishment of Class E Airspace; Star, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ... Federal Register a notice of proposed rulemaking to establish Class E airspace at Star, NC (78 FR 54413... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a... continues to read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565,...

  9. 76 FR 14802 - Establishment of Class E Airspace; Lancaster, NH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-18

    ... establish Class E airspace at Lancaster, NH (75 FR 81517). Interested parties were invited to participate in... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a.... 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0...

  10. 76 FR 60713 - Establishment of Class E Airspace; Bumpass, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    ... establish Class E airspace at Bumpass, VA (76 FR 45479) Docket No. FAA-2011-0377. Interested parties were...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of...

  11. 77 FR 29875 - Establishment of Class E Airspace; Houston, MO

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ..., area, creating controlled airspace at Houston Memorial Airport (77 FR 4711) Docket No. FAA-2011-0903..., Houston, MO. List of Subjects in 14 CFR Part 71 Airspace, Incorporation by reference, Navigation (air... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Houston, MO...

  12. 75 FR 12677 - Establishment of Class E Airspace; Shaktoolik, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-17

    ...-7587; telephone number (907) 271-5898; fax: (907) 271-2850; e-mail: gary.ctr.rolf@faa.gov . Internet.../rulemaking/ . SUPPLEMENTARY INFORMATION: History On Wednesday, December 16, 2009, the FAA published a notice of proposed rulemaking in the Federal Register to establish Class E airspace at Shaktoolik, AK (74...

  13. 75 FR 12676 - Establishment of Class E Airspace; Koyukuk, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-17

    ... number (907) 271-5898; fax: (907) 271-2850; e-mail: gary.ctr.rolf@faa.gov . Internet address: http://www.../ . SUPPLEMENTARY INFORMATION: History On Wednesday, December 16, 2009, the FAA published a notice of proposed rulemaking in the Federal Register to establish Class E airspace at Koyukuk, AK (74 FR 66594)....

  14. 76 FR 2800 - Establishment of Class E Airspace; Lucin, UT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-18

    ..., 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by.... SUPPLEMENTARY INFORMATION: History In a final rule published in the Federal Register July 8, 2010 (75 FR 39148... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Lucin, UT...

  15. 75 FR 79295 - Establishment of Class E Airspace; Crewe, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... Federal Register a notice of proposed rulemaking to establish Class E airspace at Crewe, VA (75 FR 57215...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3)...

  16. 75 FR 12161 - Establishment of Class E Airspace; Marianna, AR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-15

    ... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of... continues to read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Marianna, AR...

  17. 78 FR 34552 - Modification of Class D and Class E Airspace and Establishment of Class E Airspace; Pasco, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    ... establish Class E surface airspace and modify Class D and E airspace at Pasco, WA (78 FR 18259). Interested... 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034...), 40103, 40113, 40120; E. O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2....

  18. 75 FR 11475 - Establishment of Class D Airspace, Modification of Class E Airspace; Columbus, GA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-11

    ...; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February..., 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The incorporation by... Class E Airspace; Columbus, GA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice...

  19. 78 FR 72001 - Amendment of Class D and E Airspace, and Establishment of Class E Airspace; Salisbury, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ... surface area, and establish Class E airspace designated as an extension to a Class D surface area at... to a Class D surface area airspace is established within a 4.3-mile radius of the airport, with... E Airspace Designated as an Extension to a Class D Surface Area. * * * * * AEA MD E4 Salisbury,...

  20. Assessing a New Approach to Class-Based Affirmative Action

    ERIC Educational Resources Information Center

    Gaertner, Matthew N.

    2011-01-01

    In November, 2008, Colorado and Nebraska voted on amendments that sought to end race-based affirmative action at public universities. In anticipation of the vote, Colorado's flagship public institution--The University of Colorado at Boulder (CU)--explored statistical approaches to support class-based affirmative action. This paper details CU's…

  1. Assessing a New Approach to Class-Based Affirmative Action

    ERIC Educational Resources Information Center

    Gaertner, Matthew Newman

    2011-01-01

    In November, 2008, Colorado and Nebraska voted on amendments that sought to end race-based affirmative action at public universities in those states. In anticipation of the vote, the University of Colorado at Boulder (CU) explored statistical approaches to support class-based (i.e., socioeconomic) affirmative action. This dissertation introduces…

  2. 76 FR 70919 - Proposed Amendment of Class D and Class E Airspace, and Establishment of Class E Airspace...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-16

    ... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR... continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3... would establish Class E En Route Domestic airspace to facilitate vectoring of Instrument Flight...

  3. Social Class and Social Action: The Middle-Class Bias of Democratic Theory in Education

    ERIC Educational Resources Information Center

    Schutz, Aaron

    2008-01-01

    Background: This article examines the emergence of the middle and working classes in America and describes key characteristics of these cultures as they manifest themselves today. It then explores the effects of social class on our conceptions of democracy. Purpose: To help educators understand the relationship between social action strategies and…

  4. 75 FR 47736 - Amendment of Class D and E Airspace, Establishment of Class E Airspace; Patuxent River, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-09

    ... control tower and establish Class E airspace designated as surface areas to accommodate the additional... extension to Class D surface area at Patuxent River NAS, Patuxent River, MD, to reflect the part-time..., and establish Class E airspace designated as surface areas to provide controlled airspace required...

  5. 76 FR 77727 - Proposed Amendment of Class E Airspace; Columbia, SC, and Proposed Establishment of Class E...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-14

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Amendment of Class E Airspace; Columbia, SC, and Proposed Establishment of Class E Airspace; Pelion, SC AGENCY: Federal Aviation Administration (FAA), DOT... Columbia, SC by removing Corporate Airport from the airspace designation, and would establish Class...

  6. 78 FR 52109 - Proposed Amendment of Class D and E Airspace, and Establishment of Class E Airspace; Salisbury, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-22

    ... Wicomico Regional Airport, Salisbury, MD. Class D airspace and Class E surface area airspace would be... an extension to a Class D surface area airspace would be established within a 4.3-mile radius of the... Directory. Paragraph 6002 Class E airspace designated as surface areas. * * * * * AEA MD E2 Salisbury,...

  7. 50 CFR 530.3 - Typical classes of action.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false Typical classes of action. 530.3 Section 530.3 Wildlife and Fisheries MARINE MAMMAL COMMISSION COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL... marine mammal protection and conservation for which an EIS or environmental assessment is either...

  8. 50 CFR 530.3 - Typical classes of action.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false Typical classes of action. 530.3 Section 530.3 Wildlife and Fisheries MARINE MAMMAL COMMISSION COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL... marine mammal protection and conservation for which an EIS or environmental assessment is either...

  9. 50 CFR 530.3 - Typical classes of action.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false Typical classes of action. 530.3 Section 530.3 Wildlife and Fisheries MARINE MAMMAL COMMISSION COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL... marine mammal protection and conservation for which an EIS or environmental assessment is either...

  10. 50 CFR 530.3 - Typical classes of action.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Typical classes of action. 530.3 Section 530.3 Wildlife and Fisheries MARINE MAMMAL COMMISSION COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL... marine mammal protection and conservation for which an EIS or environmental assessment is either...

  11. 50 CFR 530.3 - Typical classes of action.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Typical classes of action. 530.3 Section 530.3 Wildlife and Fisheries MARINE MAMMAL COMMISSION COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL... marine mammal protection and conservation for which an EIS or environmental assessment is either...

  12. 28 CFR 61.5 - Typical classes of action.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Department of Justice shall independently determine whether an EIS or an environmental assessment is required... 61.5 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROCEDURES FOR IMPLEMENTING THE NATIONAL ENVIRONMENTAL POLICY ACT Implementing Procedures § 61.5 Typical classes of action. (a) The...

  13. 28 CFR 61.5 - Typical classes of action.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Department of Justice shall independently determine whether an EIS or an environmental assessment is required... 61.5 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROCEDURES FOR IMPLEMENTING THE NATIONAL ENVIRONMENTAL POLICY ACT Implementing Procedures § 61.5 Typical classes of action. (a) The...

  14. 28 CFR 61.5 - Typical classes of action.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Department of Justice shall independently determine whether an EIS or an environmental assessment is required... 61.5 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROCEDURES FOR IMPLEMENTING THE NATIONAL ENVIRONMENTAL POLICY ACT Implementing Procedures § 61.5 Typical classes of action. (a) The...

  15. 28 CFR 61.5 - Typical classes of action.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Department of Justice shall independently determine whether an EIS or an environmental assessment is required... 61.5 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROCEDURES FOR IMPLEMENTING THE NATIONAL ENVIRONMENTAL POLICY ACT Implementing Procedures § 61.5 Typical classes of action. (a) The...

  16. 28 CFR 61.5 - Typical classes of action.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Department of Justice shall independently determine whether an EIS or an environmental assessment is required... 61.5 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROCEDURES FOR IMPLEMENTING THE NATIONAL ENVIRONMENTAL POLICY ACT Implementing Procedures § 61.5 Typical classes of action. (a) The...

  17. 7 CFR 632.52 - Identifying typical classes of action.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Identifying typical classes of action. 632.52 Section 632.52 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL ABANDONED MINE PROGRAM...

  18. 7 CFR 632.52 - Identifying typical classes of action.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Identifying typical classes of action. 632.52 Section 632.52 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL ABANDONED MINE PROGRAM...

  19. 7 CFR 632.52 - Identifying typical classes of action.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Identifying typical classes of action. 632.52 Section 632.52 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL ABANDONED MINE PROGRAM...

  20. 7 CFR 632.52 - Identifying typical classes of action.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Identifying typical classes of action. 632.52 Section 632.52 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL ABANDONED MINE PROGRAM...

  1. 7 CFR 632.52 - Identifying typical classes of action.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Identifying typical classes of action. 632.52 Section 632.52 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL ABANDONED MINE PROGRAM...

  2. 76 FR 35369 - Proposed Establishment of Class D and Amendment of Class E Airspace; Los Angeles, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-17

    ... the Los Angeles VFR Task Force, and the Los Angeles Class B Workgroup. This action would further... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR... Aviation Administration proposes to amend 14 CFR part 71 as follows: PART 71--DESIGNATION OF CLASS A, B,...

  3. Regulation of androgen action during establishment of pregnancy.

    PubMed

    Gibson, Douglas A; Simitsidellis, Ioannis; Saunders, Philippa T K

    2016-07-01

    During the establishment of pregnancy, the ovarian-derived hormones progesterone and oestradiol regulate remodelling of the endometrium to promote an environment that is able to support and maintain a successful pregnancy. Decidualisation is characterised by differentiation of endometrial stromal cells that secrete growth factors and cytokines that regulate vascular remodelling and immune cell influx. This differentiation process is critical for reproduction, and inadequate decidualisation is implicated in the aetiology of pregnancy disorders such as foetal growth restriction and preeclampsia. In contrast to progesterone and oestradiol, the role of androgens in regulating endometrial function is poorly understood. Androgen receptors are expressed in the endometrium, and androgens are reported to regulate both the transcriptome and the secretome of endometrial stromal cells. In androgen-target tissues, circulating precursors are activated to mediate local effects, and recent studies report that steroid concentrations detected in endometrial tissue are distinct to those detected in the peripheral circulation. New evidence suggests that decidualisation results in dynamic changes in the expression of androgen biosynthetic enzymes, highlighting a role for pre-receptor regulation of androgen action during the establishment of pregnancy. These results suggest that such enzymes could be future therapeutic targets for the treatment of infertility associated with endometrial dysfunction. In conclusion, these data support the hypothesis that androgens play a beneficial role in regulating the establishment and maintenance of pregnancy. Future studies should be focussed on investigating the safety and efficacy of androgen supplementation with the potential for utilisation of novel therapeutics, such as selective androgen receptor modulators, to improve reproductive outcomes in women.

  4. 76 FR 64234 - Establishment of Class E Airspace; Palmyra, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... (NPRM) to amend Class E airspace 700 feet above the surface, at Palmyra, PA (76 FR 49390). Interested.... 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2... Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a Regulatory...

  5. 75 FR 26148 - Establishment of Class E Airspace; Homestead, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-11

    ... needed for the Standard Instrument Approach Procedures (SIAPs) developed for Homestead General Aviation... airspace required to support the SIAPs for Homestead General Aviation Airport. Class E airspace extending... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3)...

  6. 78 FR 1750 - Establishment of Class E Airspace; Princeton, KY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-09

    ... Class E airspace at Princeton, KY (77 FR 64919) Docket No. FAA-2011-1444. Subsequent to publication... Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a Regulatory Evaluation... continues to read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565,...

  7. 76 FR 14800 - Establishment of Class E Airspace; Wolfeboro, NH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-18

    ... Class E airspace at Wolfeboro, NH (75 FR 81518). Interested parties were invited to participate in this... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a.... 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0...

  8. 76 FR 55232 - Establishment of Class E Airspace; Copperhill, TN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-07

    ... Class E airspace at Copperhill, TN (76 FR 35370) Docket No. FAA-2011-0402. Interested parties were... Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a Regulatory Evaluation...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p....

  9. 76 FR 59503 - Establishment of Class E Airspace; Lebanon, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ... proposed rulemaking to amend Class E airspace 700 feet above the surface, at Lebanon, PA (76 FR 39038... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p....

  10. 75 FR 41772 - Establishment of Class E Airspace; Colebrook, NH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ... Procedure (SIAP) serving the Upper Valley Connecticut Hospital. This action would enhance the safety and airspace management of Instrument Flight Rules (IFR) operations in the National Airspace System. DATES... triplicate to the Docket Management System (see ADDRESSES section for address and phone number). You may...

  11. Cupreines and cupreidines: an established class of bifunctional cinchona organocatalysts.

    PubMed

    Bryant, Laura A; Fanelli, Rossana; Cobb, Alexander J A

    2016-01-01

    Cinchona alkaloids with a free 6'-OH functionality are being increasingly used within asymmetric organocatalysis. This fascinating class of bifunctional catalyst offers a genuine alternative to the more commonly used thiourea systems and because of the different spacing between the functional groups, can control enantioselectivity where other organocatalysts have failed. In the main, this review covers the highlights from the last five years and attempts to show the diversity of reactions that these systems can control. It is hoped that chemists developing asymmetric methodologies will see the value in adding these easily accessible, but underused organocatalysts to their screens. PMID:27340439

  12. Cupreines and cupreidines: an established class of bifunctional cinchona organocatalysts

    PubMed Central

    Bryant, Laura A; Fanelli, Rossana

    2016-01-01

    Summary Cinchona alkaloids with a free 6'-OH functionality are being increasingly used within asymmetric organocatalysis. This fascinating class of bifunctional catalyst offers a genuine alternative to the more commonly used thiourea systems and because of the different spacing between the functional groups, can control enantioselectivity where other organocatalysts have failed. In the main, this review covers the highlights from the last five years and attempts to show the diversity of reactions that these systems can control. It is hoped that chemists developing asymmetric methodologies will see the value in adding these easily accessible, but underused organocatalysts to their screens. PMID:27340439

  13. 76 FR 45177 - Establishment of Class E Airspace; Kayenta, AZ

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-28

    ... Navigation (RNAV) Global Positioning System (GPS) standard instrument approach procedures at Kayenta Airport... Federal Register a notice of proposed rulemaking to establish controlled airspace at Kayenta, AZ (76 FR... a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26,...

  14. 78 FR 34556 - Establishment of Class E Airspace; Tobe, CO

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    .... SUPPLEMENTARY INFORMATION: History On March 26, 2013, the FAA published in the Federal Register a notice of proposed rulemaking (NPRM) to establish controlled airspace at Tobe, CO (78 FR 18264). Interested parties... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44...

  15. 78 FR 34555 - Establishment of Class E Airspace; Gillette, WY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    .... SUPPLEMENTARY INFORMATION: History On March 26, 2013, the FAA published in the Federal Register a notice of proposed rulemaking (NPRM) to establish controlled airspace at Gillette, WY (78 FR 18266). Interested...'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not...

  16. 77 FR 68067 - Establishment of Class E Airspace; Coaldale, NV

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-15

    ... U.S.C. 106(g), 40103, 40113, 40120; E. O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71... establish controlled airspace at Coaldale, NV (77 FR 43181). Interested parties were invited to participate... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44...

  17. 78 FR 65555 - Establishment of Class E Airspace; Salmon, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-01

    ... proposed rulemaking (NPRM) to establish controlled airspace at Salmon, ID (78 FR 45478). Interested parties...'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant... FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in 14 CFR...

  18. 78 FR 65554 - Establishment of Class E Airspace; Rome, OR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-01

    ... read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959... proposed rulemaking (NPRM) to establish controlled airspace at Rome, OR (78 FR 45475). Interested parties...'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not...

  19. 76 FR 18041 - Establishment of Class E Airspace; Kahului, HI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-01

    ... establish controlled airspace at Kahului, HI (76 FR 3571). Interested parties were invited to participate in... a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979.... 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in...

  20. 75 FR 63708 - Establishment of Class E Airspace; Kalaupapa, HI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-18

    ... Federal Register a notice of proposed rulemaking to establish controlled airspace at Kalaupapa, HI (75 FR... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of... follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963...

  1. 75 FR 12974 - Establishment of Class E Airspace; Hailey, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-18

    ... E airspace at Hailey, ID, to accommodate aircraft using the Area Navigation (RNAV) Global Positioning System (GPS) Standard Instrument Approach Procedure (SIAP) at Friedman Memorial Airport. This will... Register a notice of proposed rulemaking to establish additional controlled airspace at Hailey, ID (74...

  2. 78 FR 59805 - Establishment of Class E Airspace; Cody, WY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-30

    ..., Cody, WY, to facilitate vectoring of Instrument Flight Rules (IFR) aircraft under control of Salt Lake...) to establish controlled airspace at Cody, WY (78 FR 40078). Interested parties were invited to... VOR/DME navigation aid, Cody, WY, to accommodate IFR aircraft under control of Salt Lake City ARTCC...

  3. 78 FR 59807 - Establishment of Class E Airspace; Glasgow, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-30

    ... Salt Lake City, and Minneapolis Air Route Traffic Control Centers (ARTCCs). This improves the safety... proposed rulemaking (NPRM) to establish controlled airspace at Glasgow, MT (78 FR 41337). Interested... control of Salt Lake City, and Minneapolis ARTCCs by vectoring aircraft from en route airspace to...

  4. 78 FR 31397 - Establishment of Class E Airspace; Cherokee, WY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-24

    ... Denver and Salt Lake City Air Route Traffic Control Centers (ARTCCs). This improves the safety and... proposed rulemaking (NPRM) to establish controlled airspace at Cherokee, WY (78 FR 14032). Interested... aircraft under control of Denver and Salt Lake City ARTCCs by vectoring aircraft from en route airspace...

  5. 76 FR 41397 - Establishment of Class E Airspace; Florence, OR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-14

    ... Register a notice of proposed rulemaking to establish controlled airspace at Florence, OR (76 FR 21269... 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034.... 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in...

  6. 77 FR 44120 - Establishment of Class E Airspace; Roundup, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-27

    ... notice of proposed rulemaking (NPRM) to establish controlled airspace at Roundup, MT (77 FR 27148... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The...

  7. 78 FR 67298 - Establishment of Class E Airspace; Ennis, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ... rulemaking (NPRM) to establish controlled airspace at Ennis, MT (78 FR 54415). Interested parties were... 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034...), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2....

  8. 76 FR 57634 - Establishment of Class E Airspace; Chinle, AZ

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-16

    ... Federal Register a notice of proposed rulemaking to establish controlled airspace at Chinle, AZ (76 FR... a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979.... 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in...

  9. 75 FR 57374 - Establishment of Class E Airspace; Fillmore, UT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-21

    ... Federal Register a notice of proposed rulemaking to establish controlled airspace at Fillmore, UT (75 FR... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of... follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963...

  10. 77 FR 38476 - Establishment of Class E Airspace; Eureka, NV

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-28

    ... notice of proposed rulemaking to establish controlled airspace at Eureka, NV (77 FR 21509). Interested... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does.... 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in...

  11. 78 FR 17084 - Establishment of Class E Airspace; Wilbur, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-20

    ... proposed rulemaking (NPRM) to establish controlled airspace at Wilbur, WA (77 FR 75597). Interested parties... ``significant rule'' under DOT Regulatory Policies and Procedures (44 ] FR 11034; February 26, 1979); and (3..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation...

  12. Consumers versus managed care: the new class actions.

    PubMed

    Havighurst, C C

    2001-01-01

    The plaintiffs in pending consumer class-action lawsuits against health maintenance organizations (HMOs) should fail in their claims for damages for fraud under federal anti-racketeering legislation. Although HMOs have regularly failed to disclose their business methods and have not strictly honored their contractual coverage promises, the circumstances in which they introduced cost controls into a market sadly lacking them suggest motives not deserving punitive sanctions. Courts could easily find that HMOs violated the Employee Retirement Income Security Act (ERISA), however. Injunctive relief compelling more extensive disclosures and clearer contracts might well legitimize HMOs' methods and generally improve the performance of the health care marketplace.

  13. 76 FR 64233 - Amendment of Class D and Class E Airspace and Establishment of Class E Airspace; Casper, WY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ..., published on August 25, 2011 (76 FR 53048), amends Class D airspace, Class E surface airspace, Class E..., the Class E airspace descriptions as published in the Federal Register of August 25, 2011 (76 FR 53048) (FR Doc. 2011-21663) for Natrona County International Airport, Casper, WY, is corrected under...

  14. 75 FR 59608 - Amendment of Class D and E Airspace; Establishment of Class E Airspace; Patuxent River, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-28

    ... airspace designated as surface areas to accommodate Standard Instrument Approach Procedures (SIAPs... designated as an extension to Class D surface area at Patuxent River NAS (Trapnell Field), Patuxent River, MD... and times by a Notice to Airmen, and establishes Class E surface area airspace to provide...

  15. 78 FR 25403 - Proposed Amendment of Class E Airspace; Dayton, TN, Establishment of Class E Airspace; Cleveland...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-01

    ... Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a Regulatory Evaluation... read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959..., Establishment of Class E Airspace; Cleveland, TN, and Revocation of Class E Airspace; Bradley Memorial...

  16. 29 CFR 1608.4 - Establishing affirmative action plans.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... AFFIRMATIVE ACTION APPROPRIATE UNDER TITLE VII OF THE CIVIL RIGHTS ACT OF 1964, AS AMENDED § 1608.4... reasonable action. (a) Reasonable self analysis. The objective of a self analysis is to determine whether... disparate treatment of previously excluded or restricted groups or leave uncorrected the effects of...

  17. 78 FR 33965 - Establishment of Class E Airspace; Immokalee-Big Cypress Airfield, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ..., establishes Class E airspace at Big Cypress Airfield, Immokalee, FL (78 FR 25384). Subsequent to publication..., 2013 (78 FR 25384) FR Doc. 2013-10214, is corrected to read ``. . . Immokalee-Big Cypress, FL''; and in... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Immokalee-Big...

  18. 75 FR 32268 - Establishment of Class E Airspace; Mount Pleasant, SC.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-08

    ... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Mount Pleasant, SC... Register April 1, 2010 that establishes Class E airspace at Mt Pleasant Regional Airport-Faison Field, Mount Pleasant, SC. DATES: Effective Date: 0901 UTC, June 8, 2010. FOR FURTHER INFORMATION...

  19. 76 FR 52596 - Proposed Establishment of Class C Airspace for Long Beach, CA; Public Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-23

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class C Airspace for Long Beach... airspace users and others, concerning a proposal to establish Class C airspace at Long Beach, CA. The... on or before December 12, 2011. ADDRESSES: The meetings will be held at the Holiday Inn Long...

  20. 75 FR 20774 - Establishment of Class E Airspace; Fort A.P. Hill, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... final rule with a request for comments in the Federal Register on December 7, 2009 (74 FR 63974), Docket... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Fort A.P. Hill, VA... Register December 7, 2009 that establishes Class E airspace at Fort A.P. Hill, VA. DATES: Effective...

  1. 75 FR 20774 - Establishment of Class E Airspace; Mountain City, TN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... FR 63976), Docket No. FAA-2009-0061; Airspace Docket No. 09-ASO-10. The FAA uses the direct final... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Mountain City, TN AGENCY... December 7, 2009 that establishes Class E airspace at Johnson County Airport, Mountain City, TN....

  2. 78 FR 62498 - Proposed Establishment of Class E Airspace, Amendment of Class D and Class E Airspace, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... Class E airspace designated as surface area. The geographic coordinates of the airport also would be... extension to Class D surface area would be modified from the 4.3-mile radius of the airport to 8 miles... modification eliminates the need for Class E airspace designated as surface area, and, therefore, would...

  3. Energy Master dealers mull class action: overpricing, bad support charged

    SciTech Connect

    Schwartz, R.

    1982-04-19

    Thirteen disgruntled Energy Master Inc. (EMI) dealers may take out a class-action suit against the firm and World Wide Energy Systems Inc., both based in Atlanta, because of alleged overpricing, poor service practices, and misrepresentations. EMI was organized in 1977 by persons who have since served prison terms for unrelated mail fraud, but the new management blames dealer unhappiness on poor selling efforts. The company has increased dealer training, but cannot make up for all the problems dating from past management. World Wide Energy Systems denies any connection with economic prices, and some dealers see no cause to join in the suit. Dealers complain, however, that their background is inadequate for the technical requirements of handling the systems. (DCK)

  4. 75 FR 13698 - Establishment of Class D Airspace, Modification of Class E Airspace; Columbus, GA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    ... Register on March 11, 2010 (75 FR 11475), is hereby withdrawn. Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Issued in College Park, Georgia, on March... Airspace; Columbus, GA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of...

  5. 42 CFR 416.185 - Process for establishing a new class of new technology IOLs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Adjustment in Payment Amounts for New Technology Intraocular Lenses Furnished by Ambulatory Service Centers § 416.185 Process for establishing a new class of new technology IOLs. (a) Announcement of deadline for... new classes of new technology IOLs for which review requests have been made and solicitation of...

  6. 42 CFR 416.185 - Process for establishing a new class of new technology IOLs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Payment Amounts for New Technology Intraocular Lenses Furnished by Ambulatory Service Centers § 416.185 Process for establishing a new class of new technology IOLs. (a) Announcement of deadline for requests for review. CMS announces the deadline for each year's requests for review of a new class of new...

  7. 7 CFR 201.71 - Establishing the source of all classes of certified seed.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... seed. 201.71 Section 201.71 Agriculture Regulations of the Department of Agriculture (Continued... (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Certified Seed § 201.71 Establishing the source of all classes of certified seed. The certifying agency shall have evidence of the class and source...

  8. 7 CFR 201.71 - Establishing the source of all classes of certified seed.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... seed. 201.71 Section 201.71 Agriculture Regulations of the Department of Agriculture (Continued... (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Certified Seed § 201.71 Establishing the source of all classes of certified seed. The certifying agency shall have evidence of the class and source...

  9. 7 CFR 201.71 - Establishing the source of all classes of certified seed.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... seed. 201.71 Section 201.71 Agriculture Regulations of the Department of Agriculture (Continued... (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Certified Seed § 201.71 Establishing the source of all classes of certified seed. The certifying agency shall have evidence of the class and source...

  10. 7 CFR 201.71 - Establishing the source of all classes of certified seed.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... seed. 201.71 Section 201.71 Agriculture Regulations of the Department of Agriculture (Continued... (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Certified Seed § 201.71 Establishing the source of all classes of certified seed. The certifying agency shall have evidence of the class and source...

  11. 7 CFR 201.71 - Establishing the source of all classes of certified seed.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... seed. 201.71 Section 201.71 Agriculture Regulations of the Department of Agriculture (Continued... (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Certified Seed § 201.71 Establishing the source of all classes of certified seed. The certifying agency shall have evidence of the class and source...

  12. 78 FR 58158 - Establishment of Class D Airspace; Bryant AAF, Anchorage, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-23

    ... Register establishing Class D airspace at Bryant AAF, Anchorage, AK (78 FR 48299, August 8, 2013). In the..., as published in the Federal Register on August 8, 2013 (78 FR 48299), FR Doc. 2013-18866, are... description for Bryant AAF, in that the language indicating Class D airspace as part time was left out....

  13. 77 FR 37569 - Establishment of Class D Airspace and Amendment of Class E Airspace; East Hampton, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-22

    ... Hampton, NY, to accommodate a new air traffic control tower at East Hampton Airport (77 FR 15297... establishes higher weather minima for VFR flights, thus restricting access of VFR flights to the airspace... Class D airspace during adverse weather conditions. While the FAA agrees that one-at-a-time Special...

  14. 78 FR 72006 - Establishment of Class D Airspace and Class E Airspace; Laguna AAF, AZ

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ... Register a notice of proposed rulemaking (NPRM) to establish controlled airspace at Laguna AAF, AZ (78 FR... Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a regulatory evaluation... read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E. O. 10854, 24 FR 9565, 3 CFR,...

  15. 78 FR 2879 - Establishment of Class D and Class E Airspace; Camp Guernsey, WY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-15

    ..., 1601 Lind Avenue SW., Renton, WA 98057; telephone (425) 203-4537. SUPPLEMENTARY INFORMATION: History On... establish controlled airspace at Camp Guernsey Airport, Camp Guernsey, WY (77 FR 56174). Interested parties... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3)...

  16. 75 FR 63709 - Revocation of Class C Airspace, Establishment of Class D Airspace, and Modification of Class E...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-18

    ... area and the 700 foot Class E airspace area at Columbus, GA (75 FR 27670). Interested parties were... Transportation (DOT) Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not... read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR,...

  17. 77 FR 48060 - Establishment of Class E Airspace; Fort Morgan, CO

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-13

    ... notice of proposed rulemaking (NPRM) to establish controlled airspace at Fort Morgan, CO (77 FR 33687... U.S.C. 106(g), 40103, 40113, 40120; E. O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Fort Morgan, CO...

  18. 78 FR 40381 - Establishment of Class E Airspace; Grand Canyon, AZ

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-05

    ...) to establish controlled airspace at Grand Canyon, AZ (78 FR 25404). Interested parties were invited... Administration 14 CFR Part 71 Establishment of Class E Airspace; Grand Canyon, AZ AGENCY: Federal Aviation... Canyon VHF Omni-Directional Radio Range/Distance Measuring Equipment (VOR/DME) navigation aid,...

  19. 75 FR 42631 - Proposed Establishment of Class E Airspace; Wolfeboro, NH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-22

    ...) serving Huggins Hospital. This action would enhance the safety and airspace management of Instrument...; Airspace Docket No. 10-ANE-104) and be submitted in triplicate to the Docket Management System (see... airspace required to support the special SIAPs for Huggins Hospital. The existing Class E...

  20. 76 FR 75448 - Establishment of Class D and E Airspace; Frederick, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-02

    ... Class D and E airspace at Frederick, MD, to accommodate new Area Navigation (RNAV) Global Positioning System (GPS) Standard Instrument Approach Procedures (SIAPs) at Frederick Municipal Airport. This action... and E airspace for the new Frederick Municipal Airport, Frederick, MD (76 FR 50156) Docket No....

  1. 77 FR 9839 - Amendment of Class D and Class E Airspace, and Establishment of Class E Airspace; Bozeman, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-21

    ... rulemaking to amend and establish controlled airspace at Bozeman, MT (76 FR 70919). Interested parties were... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does.... 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in...

  2. The role of monoamines in the actions of established and "novel" antidepressant agents: a critical review.

    PubMed

    Millan, Mark J

    2004-10-01

    Monoaminergic pathways are highly responsive to aversive stimuli and play a crucial role in the control of affect, cognition, endocrine secretion, chronobiotic rhythms, appetite, and motor function, all of which are profoundly disrupted in depressive states. Accordingly, a perturbation of monoaminergic transmission is implicated in the aetiology of depressive disorders, and all clinically available antidepressants increase corticolimbic availability of monoamines. However, their limited efficacy, delayed onset of action, and undesirable side effects underlie ongoing efforts to identify improved therapeutic agents. Sequencing the human genome has raised the hope not only of better symptomatic control of depression, but even of the prevention or cure of depressive states. In the pursuit of these goals, there is currently a tendency to focus on selective ligands of "novel" nonmonoaminergic targets. However, certain classes of novel agent (such as neurokinin(1) receptor antagonists) indirectly modulate the activity of monoaminergic networks. Others may act "downstream" of them, converging onto common cellular substrates controlling gene expression, synaptic plasticity, and neurogenesis. Further, by analogy to the broad-based actions of currently employed drugs, multitarget agents may be better adapted than selective agents to the management of depression-a complex disorder with hereditary, developmental, and environmental origins. It is, thus, important to continue the creative exploration of clinically validated and innovative monoaminergic strategies within a multitarget framework. In this light, drugs combining monoaminergic and nonmonoaminergic mechanisms of action may be of particular interest. The present article provides a critical overview of monoaminergic strategies for the treatment of depressive states, both established and under development, and discusses interactions of novel "nonmonoaminergic" antidepressants with monoaminergic mechanisms.

  3. "Hoffman v. Monsanto": Courts, Class Actions, and Perceptions of the Problem of GM Drift

    ERIC Educational Resources Information Center

    McLeod-Kilmurray, Heather

    2007-01-01

    "Hoffman v. Monsanto" raises questions about the civil litigation system. Are courts appropriate institutions, and are class actions the appropriate procedure, for resolving disputes about genetically modified organisms (GMOs)? After addressing the institutional question, this article focuses on procedure. Although class actions are designed to…

  4. 75 FR 34393 - Proposed Establishment of Class E Airspace; Port Clarence, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-17

    ... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of... continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Port...

  5. 75 FR 62457 - Establishment of Class E Airspace; Port Clarence, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-12

    ... Federal Register to establish Class E airspace at Port Clarence, AK (75 FR 34393). Interested parties were... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does... U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec....

  6. 76 FR 44288 - Establishment of Class E Airspace; New Market, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-25

    ...; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; New Market, VA...

  7. 76 FR 64236 - Establishment of Class E Airspace; New Market, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... establish Class E airspace at New Market, VA (76 FR 44288). Interested parties were invited to participate... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does... continues to read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565,...

  8. 42 CFR 416.185 - Process for establishing a new class of new technology IOLs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... technology IOLs. 416.185 Section 416.185 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT... Adjustment in Payment Amounts for New Technology Intraocular Lenses Furnished by Ambulatory Service Centers § 416.185 Process for establishing a new class of new technology IOLs. (a) Announcement of deadline...

  9. 42 CFR 416.185 - Process for establishing a new class of new technology IOLs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... technology IOLs. 416.185 Section 416.185 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT... Adjustment in Payment Amounts for New Technology Intraocular Lenses Furnished by Ambulatory Service Centers § 416.185 Process for establishing a new class of new technology IOLs. (a) Announcement of deadline...

  10. 42 CFR 416.185 - Process for establishing a new class of new technology IOLs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... technology IOLs. 416.185 Section 416.185 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT... Payment Amounts for New Technology Intraocular Lenses Furnished by Ambulatory Service Centers § 416.185 Process for establishing a new class of new technology IOLs. (a) Announcement of deadline for requests...

  11. 76 FR 50156 - Proposed Establishment of Class D and E Airspace; Frederick, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-12

    ... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of..., 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The incorporation by... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class D and E Airspace;...

  12. 76 FR 3571 - Proposed Establishment of Class E Airspace; Kahului, HI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-20

    ... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The incorporation by... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Kahului,...

  13. 75 FR 49868 - Proposed Establishment of Class E Airspace; Kalaupapa, HI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ... Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a regulatory evaluation... follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Kalaupapa,...

  14. 78 FR 54413 - Proposed Establishment of Class E Airspace; Star, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-04

    ... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does...); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Star, NC...

  15. 77 FR 4713 - Proposed Establishment of Class E Airspace; Red Cloud, NE

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-31

    ... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a... continues to read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Red Cloud,...

  16. 77 FR 4709 - Proposed Establishment of Class E Airspace; Branson West, MO

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-31

    ...'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant... continues to read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Branson...

  17. 77 FR 33687 - Proposed Establishment of Class E Airspace; Fort Morgan, CO

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-07

    ... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR... follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Fort Morgan,...

  18. 75 FR 68558 - Proposed Establishment of Class E Airspace; New Hampton, IA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-08

    ...'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant... continues to read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; New Hampton,...

  19. 76 FR 53360 - Proposed Establishment of Class E Airspace; Stuart, IA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-26

    ... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of... read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Stuart,...

  20. 77 FR 27148 - Proposed Establishment of Class E Airspace; Roundup, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-09

    ...'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and does not warrant... 71 continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR... TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace;...

  1. 75 FR 81517 - Proposed Establishment of Class E Airspace; Lancaster, NH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ... not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26... follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Lancaster,...

  2. 75 FR 42630 - Proposed Establishment of Class E Airspace; Lancaster, NH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-22

    ... not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Lancaster,...

  3. Techniques of Play Activity at Physical Education Classes at Specialized Secondary Educational Establishments

    ERIC Educational Resources Information Center

    Martynova, Victoria A.; Kapustin, Aleksandr G.

    2016-01-01

    The issue is urgent today because at present the organization and content of Physical Education (PE) classes at specialized secondary educational establishments (SSEEs) do not completely meet contemporary requirements. The following negative trends prove that, namely: the physical and psychological health decline in school leavers and students,…

  4. 78 FR 72007 - Establishment of Class E Airspace; McConnellsburg, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ... proposed rulemaking (NPRM) to establish Class E airspace at McConnellsburg, PA, (78 FR 48081) Docket No... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The...

  5. 78 FR 41335 - Proposed Establishment of Class E Airspace; Battle Mountain, NV

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-10

    ... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR... continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Battle...

  6. 78 FR 68699 - Establishment of Class E Airspace; Battle Mountain, NV

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-15

    ... establishing Class E airspace at the Battle Mountain VORTAC navigation aid, Battle Mountain, NV (78 FR 58159... heading, as published in the Federal Register on September 23, 2013 (78 FR 58159), Airspace Docket No. 13- AWP-9, FR Doc. 2013-58159, is corrected as follows: On page 58160, column 1, line 2, remove...

  7. 77 FR 75598 - Proposed Establishment of Class E Airspace; White Mountain, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-21

    ... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of... 71 continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; White...

  8. 78 FR 48838 - Proposed Establishment of Class E Airspace; Curtis, NE

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-12

    ...'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant... continues to read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Curtis,...

  9. 76 FR 39038 - Proposed Establishment of Class E Airspace; Lebanon, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-05

    ...'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant.... 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The incorporation by reference in 14 CFR... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Lebanon,...

  10. 78 FR 45478 - Proposed Establishment of Class E Airspace; Salmon, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-29

    ... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Salmon,...

  11. 77 FR 50646 - Proposed Establishment of Class D Airspace; Bryant AAF, Anchorage, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-22

    ... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR....S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class D Airspace; Bryant...

  12. 77 FR 41108 - Proposed Establishment of Class E Airspace; Fort Garland, CO

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-12

    ... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The incorporation by... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Fort...

  13. 78 FR 14479 - Proposed Establishment of Class E Airspace; Boca Grande, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-06

    ...'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant... continues to read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Boca Grande,...

  14. 78 FR 25234 - Proposed Establishment of Class E Airspace; Walker, MN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    ... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of... read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Walker,...

  15. 78 FR 18267 - Proposed Establishment of Class E Airspace; Elbow Lake, MN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ...; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Elbow Lake,...

  16. 75 FR 22044 - Proposed Establishment of Class E Airspace; Paynesville, MN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-27

    ...; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February.... 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Paynesville,...

  17. 75 FR 3879 - Proposed Establishment of Class E Airspace; Luverne, MN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-25

    ...; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February.... 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Luverne,...

  18. 78 FR 41290 - Establishment of Class E Airspace; Elbow Lake, MN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-10

    ... establish Class E airspace at Elbow Lake Municipal--Pride of the Prairie Airport, Elbow Lake, MN (78 FR... 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034... read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E. O. 10854, 24 FR 9565, 3 CFR,...

  19. 78 FR 25233 - Proposed Establishment of Class E Airspace; Mahnomen, MN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    ...'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant... read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Mahnomen,...

  20. 76 FR 53359 - Proposed Establishment of Class E Airspace; Nashville, AR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-26

    ...; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February.... 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Nashville,...

  1. 75 FR 62460 - Revocation and Establishment of Class E Airspace; Northeast Alaska, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-12

    ... address: http://www.faa.gov/about/office_org/headquarters_offices/ato/service_units/systemops/fs/alaskan... establish other Class E airspace near the Eagle Airport, Eagle, AK (75 FR 30746). The proposal did not fully... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3)...

  2. 21 CFR 509.4 - Establishment of tolerances, regulatory limits, and action levels.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... IN ANIMAL FOOD AND FOOD-PACKAGING MATERIAL General Provisions § 509.4 Establishment of tolerances... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Establishment of tolerances, regulatory limits, and action levels. 509.4 Section 509.4 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT...

  3. As the Pendulum Swings—Medical Products Class Actions Litigation in Canada: Recent Developments

    PubMed Central

    Pliszka, Peter J.; Armstrong, Sarah J.

    2013-01-01

    During the relatively short history of class proceedings in Canada, developers and manufacturers of medical devices and pharmaceuticals (“medical products”), including medical products designed for patients with diabetes, have found themselves at the receiving end of a significant number of class action claims. As a result, medical products litigation has become the battleground for some of the most significant developments in Canadian class actions law. This article provides a broad overview of some of the most significant developments. The authors pay particular attention to developments regarding the test for class action certification and consider whether high-profile dismissals of certification motions represent a trend toward raising the threshold for plaintiffs seeking to obtain certification of a proposed class action. The authors also consider a decision arising out of a lengthy class action common issues trial in which the medical device company was victorious. In the authors’ view, the class action pendulum in Canada, particularly as it relates to medical products claims, remains in motion. It behooves all affected players to keep their eye on this ball with rapt attention to see where it may move next. PMID:23566988

  4. As the pendulum swings--medical products class actions litigation in Canada: recent developments.

    PubMed

    Pliszka, Peter J; Armstrong, Sarah J

    2013-03-01

    During the relatively short history of class proceedings in Canada, developers and manufacturers of medical devices and pharmaceuticals ("medical products"), including medical products designed for patients with diabetes, have found themselves at the receiving end of a significant number of class action claims. As a result, medical products litigation has become the battleground for some of the most significant developments in Canadian class actions law. This article provides a broad overview of some of the most significant developments. The authors pay particular attention to developments regarding the test for class action certification and consider whether high-profile dismissals of certification motions represent a trend toward raising the threshold for plaintiffs seeking to obtain certification of a proposed class action. The authors also consider a decision arising out of a lengthy class action common issues trial in which the medical device company was victorious. In the authors' view, the class action pendulum in Canada, particularly as it relates to medical products claims, remains in motion. It behooves all affected players to keep their eye on this ball with rapt attention to see where it may move next.

  5. Co-Teaching an Online Action Research Class

    ERIC Educational Resources Information Center

    Wilson, Brent G.; Linder VanBerschot, Jennifer

    2014-01-01

    Two instructors report our experience co-teaching an action research (AR) required as part of an e-learning master's degree. Adopting a practice-centered stance we focus on the course activities of participants (instructors and students), with particular attention to the careful crafting of course elements with the goal of achieving an…

  6. 23 CFR 771.115 - Classes of actions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... on a new location. (3) New construction or extension of fixed rail transit facilities (e.g., rapid rail, light rail, commuter rail, automated guideway transit). (4) New construction or extension of a... significantly affect the environment require an EIS (40 CFR 1508.27). The following are examples of actions...

  7. 23 CFR 771.115 - Classes of actions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... on a new location. (3) New construction or extension of fixed rail transit facilities (e.g., rapid rail, light rail, commuter rail, automated guideway transit). (4) New construction or extension of a... significantly affect the environment require an EIS (40 CFR 1508.27). The following are examples of actions...

  8. 23 CFR 771.115 - Classes of actions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... on a new location. (3) New construction or extension of fixed rail transit facilities (e.g., rapid rail, light rail, commuter rail, automated guideway transit). (4) New construction or extension of a... significantly affect the environment require an EIS (40 CFR 1508.27). The following are examples of actions...

  9. 7 CFR 3407.5 - Classes of action.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... are determined to have a significant impact on the quality of the human environment or which will be... individual or cumulative effect on the quality of the human environment. These include those activities... or cumulative effects on the quality of the human environment. Such actions generally include...

  10. NIH study uncovers new mechanism of action for class of chemotherapy drugs

    Cancer.gov

    NIH researchers have discovered a significant new mechanism of action for a class of chemotherapy drugs known as poly (ADP-ribose) polymerase inhibitors, or PARP inhibitors. They have also identified differences in the toxic capabilities of three drugs in

  11. 76 FR 80231 - Establishment of Class D and E Airspace and Amendment of Class E; Punta Gorda, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-23

    ... as an extension to Class D surface area. The existing Class E airspace area extending upward from 700... published in the Airport/Facility Directory. Paragraph 6002 Class E airspace designated as surface areas.... Paragraph 6004 Class E airspace areas designated as an extension to a class D surface area. * * * * * ASO...

  12. The Back Pay Remedy in Title VII Class Actions: Problems of Procedure

    ERIC Educational Resources Information Center

    Edwards, Charles A.

    1974-01-01

    The class action for back pay has developed as a significant factor in employment discrimination litigation under Title VII of the Civil Rights Act of 1964. Problems of demonstrating each class member's entitlement are examined and a bifurcated trial procedure is proposed as a method for handling such cases. (JT)

  13. Naming Action in Japanese: Effects of Semantic Similarity and Grammatical Class

    ERIC Educational Resources Information Center

    Iwasaki, Noriko; Vinson, David P.; Vigliocco, Gabriella; Watanabe, Masumi; Arciuli, Joanne

    2008-01-01

    This study investigated whether the semantic similarity and grammatical class of distracter words affects the naming of pictured actions (verbs) in Japanese. Three experiments used the picture-word interference paradigm with participants naming picturable actions while ignoring distracters. In all three experiments, we manipulated the semantic…

  14. Phonemic Awareness Education with an ESL Class. Action Research Monograph.

    ERIC Educational Resources Information Center

    Barton, Anne Y.

    This study was designed to include a segment of phonemic awareness in a multi-level English-as-a-Second-Language (ESL) classroom as learning progress seemed to be inhibited in part by a lack of understanding of the structure of the English language. A survey was developed and administered to measure student progress to establish a baseline.…

  15. Esperamicins, a class of potent antitumor antibiotics: mechanism of action.

    PubMed

    Long, B H; Golik, J; Forenza, S; Ward, B; Rehfuss, R; Dabrowiak, J C; Catino, J J; Musial, S T; Brookshire, K W; Doyle, T W

    1989-01-01

    The esperamicins represent a class of antitumor antibiotics characterized by an unusual chemical core structure and extremely potent cytotoxicity. The mechanism by which these drugs produce cytotoxicity was investigated and found to be related to the formation of single- and double-strand DNA breaks. Using five structurally related analogs, we defined a structure-activity relationship for cytotoxicity in various eukaryotic and DNA-repair-deficient prokaryotic cell lines, for DNA breakage in a human colon carcinoma cell line, and for DNA breakage in vitro in pBR322 DNA. Mild reducing agents such as dithiothreitol greatly increased the DNA breakage potency of these analogs in vitro. Results suggest that the pendant aromatic chromophore of esperamicin A1 may contribute to the uptake of the drug into cells but may also hinder double-strand DNA break formation. Little DNA breakage specificity was observed for the drug in a 139-base-pair fragment of pBR322 DNA. Evidence supports a previously proposed mechanism whereby esperamicins may produce the observed DNA breaks through reduction of the methyl trisulfide group to a thiolate anion followed by a Michael addition of the anion across the alpha,beta-unsaturated ketone. This addition may result in the saturation of the bridgehead double bond, thus allowing the two triple bonds to approach each other, causing cyclization of the diyn-ene to form a phenylene diradical. It is likely that this diradical is the active form of the drug responsible for single- and double-strand DNA breakage produced by this class of antitumor agents.

  16. 21 CFR 109.4 - Establishment of tolerances, regulatory limits, and action levels.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Establishment of tolerances, regulatory limits, and action levels. 109.4 Section 109.4 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION UNAVOIDABLE CONTAMINANTS IN FOOD FOR HUMAN CONSUMPTION AND FOOD-PACKAGING...

  17. Industrial Sites Project Establishment of Final Action Levels, Rev. No.: 0

    SciTech Connect

    Boehlecke, Robert F.

    2006-02-01

    The U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) oversees numerous sites on the Nevada Test Site (NTS) and other locations in the State of Nevada that have been impacted by activities related to the development and testing of nuclear devices and by other activities. NNSA/NSO is responsible for protecting members of the public, including site workers, from harmful exposure to both chemical and radiological contaminants at these sites as they remediate these sites. The Nevada Division of Environmental Protection (NDEP) is the primary state agency responsible for protection of human health and the environment with respect to chemical and radiological wastes. In 1996 the DOE, U.S. Department of Defense, and the State of Nevada entered into an agreement known as the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996). Appendix VI to the FFACO describes the strategy employed to plan, implement, and complete environmental corrective action activities at NTS and other locations in the state of Nevada. One of the categories of corrective action units (CAUs) is Industrial Sites, which consists of approximately 1,150 locations that may require some level of investigation and corrective action. To evaluate the need for the extent of corrective action at a particular site, NNSA/NSO assesses the potential impacts to receptors by comparing measurements of contaminant concentrations to risk-based (chemical) and dose-based (radionuclide) standards (action levels). Preliminary action levels (PALs) are established as part of the data quality objective (DQO) process, and are presented in one or more FFACO documents generated as part of the corrective action process. This document formally defines and clarifies the NDEP-approved process NNSA/NSO Industrial Sites Project uses to fulfill the requirements of the FFACO and state regulations. This process establishes final action levels (FALs) based on the risk

  18. Maintenance of MHC Class IIB diversity in a recently established songbird population

    PubMed Central

    Whittaker, Danielle J.; Dapper, Amy L.; Peterson, Mark P.; Atwell, Jonathan W.; Ketterson, Ellen D.

    2012-01-01

    We examined variation at MHC Class IIB genes in a recently established population of dark-eyed juncos (Junco hyemalis) in a coastal urban environment in southern California, USA relative to an ancestral-range population from a nearby species-typical montane environment. The founding population is estimated to have been quite small, but we predicted that variation at the major histocompatibility complex (MHC) among the founders would nevertheless be preserved owing to the high functional significance of MHC. Previous studies of MHC in songbirds have had varying degrees of success in isolating loci, as passerines show extensive MHC gene duplication. In order to compare diversity in the two populations, we employed two published approaches to sequencing MHC Class II exon 2: direct sequencing with exon-based primers, and traditional cloning and sequencing with intron-based primers. Results from both methods show that the colonist population has maintained high levels of variation. Our results also indicate varying numbers of alleles across individuals, corroborating evidence for gene duplication in songbird MHC. While future studies in songbirds may need to take a genomic approach to fully understand the structure of MHC in this lineage, our results show that it is possible to use traditional methods to reveal functional variation across populations. PMID:22685370

  19. Maintenance of MHC Class IIB diversity in a recently established songbird population.

    PubMed

    Whittaker, Danielle J; Dapper, Amy L; Peterson, Mark P; Atwell, Jonathan W; Ketterson, Ellen D

    2012-03-01

    We examined variation at MHC Class IIB genes in a recently established population of dark-eyed juncos (Junco hyemalis) in a coastal urban environment in southern California, USA relative to an ancestral-range population from a nearby species-typical montane environment. The founding population is estimated to have been quite small, but we predicted that variation at the major histocompatibility complex (MHC) among the founders would nevertheless be preserved owing to the high functional significance of MHC. Previous studies of MHC in songbirds have had varying degrees of success in isolating loci, as passerines show extensive MHC gene duplication. In order to compare diversity in the two populations, we employed two published approaches to sequencing MHC Class II exon 2: direct sequencing with exon-based primers, and traditional cloning and sequencing with intron-based primers. Results from both methods show that the colonist population has maintained high levels of variation. Our results also indicate varying numbers of alleles across individuals, corroborating evidence for gene duplication in songbird MHC. While future studies in songbirds may need to take a genomic approach to fully understand the structure of MHC in this lineage, our results show that it is possible to use traditional methods to reveal functional variation across populations.

  20. The Luke S. Class Action Suit: A Lesson in System Change.

    ERIC Educational Resources Information Center

    Taylor, John M.; And Others

    1986-01-01

    The background and effects of Luke S. and Hans S. vs. Nix et al, a class action suit in Louisiana are discussed. The resulting changes in assessment practices, includng prereferral intervention, curriculum based assessment, and state-wide inservice training for assessment staff are noted. (Author/CL)

  1. For the Welfare of Children: Lessons Learned from Class Action Litigation

    ERIC Educational Resources Information Center

    Meltzer, Judith, Ed.; Joseph, Rachel Molly, Ed.; Shookhoff, Andy, Ed.

    2012-01-01

    This series of papers brings together distinguished experts writing on the use of class action litigation to reform public child welfare systems. It is an effort to tease out of four decades of experience in this work, the factors that increase the likelihood that litigation will result in successful system reform. This publication is an outgrowth…

  2. The Use of Psychodrama Action Techniques in a Race Relations Class

    ERIC Educational Resources Information Center

    Kranz, Peter L.; Ramirez, Sylvia Z.; Lund, Nick L.

    2007-01-01

    This article describes psychodrama action techniques that were effectively implemented in a university-level race relations course. Essential elements of these techniques included acting out and critical self-examination of the individual's personal beliefs. In a semi-structured class format in which uncensored spontaneity was stressed, students…

  3. 7 CFR 1940.318 - Completing environmental assessments for Class II actions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 13 2014-01-01 2013-01-01 true Completing environmental assessments for Class II actions. 1940.318 Section 1940.318 Agriculture Regulations of the Department of Agriculture (Continued... AGENCY, DEPARTMENT OF AGRICULTURE (CONTINUED) PROGRAM REGULATIONS (CONTINUED) GENERAL...

  4. 7 CFR 1940.319 - Completing environmental assessments for Class I actions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 13 2014-01-01 2013-01-01 true Completing environmental assessments for Class I actions. 1940.319 Section 1940.319 Agriculture Regulations of the Department of Agriculture (Continued... AGENCY, DEPARTMENT OF AGRICULTURE (CONTINUED) PROGRAM REGULATIONS (CONTINUED) GENERAL...

  5. 10 CFR Appendix D to Subpart D of... - Classes of Actions That Normally Require EISs

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... hazardous waste as designated in 40 CFR part 261). D12Siting, construction, and operation of incinerators... designated in 40 CFR part 261.4(b)). ... 10 Energy 4 2010-01-01 2010-01-01 false Classes of Actions That Normally Require EISs D Appendix...

  6. New tainted-blood class actions in Québec and Alberta.

    PubMed

    2003-08-01

    In two cases in Québec and Alberta, people infected with HIV and HCV through infected blood and blood products have successfully defended motions to strike out all or parts of their legal actions against federal and provincial governments and the Canadian Red Cross Society (CRCS). On 16 January 2003, the Québec Superior Court ruled that the plaintiffs in a class action could rely on the Krever Commission Report in their application for certification of a class proceeding. On 20 February 2003, the Alberta Court of Queen's Bench dismissed an application brought by the Canadian and Alberta governments to strike out the legal action brought against them. These cases illustrate that the settlement schemes proposed by the federal and provincial governments and the CRCS, and approved by the courts, have not put an end to the civil and constitutional claims brought by people seeking compensation for infection through tainted blood.

  7. 75 FR 30746 - Proposed Revocation and Establishment of Class E Airspace; Northeast, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-02

    ... providing service to Eagle, AK, must currently operate under Visual Flight Rules (VFR). With the... Regulatory Policies ] and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation... A, CLASS B, CLASS C, CLASS D, AND CLASS E AIRSPACE AREAS; AIR TRAFFIC SERVICE ROUTES; AND...

  8. Voluntary Climate Change Mitigation Actions of Young Adults: A Classification of Mitigators through Latent Class Analysis

    PubMed Central

    Korkala, Essi A. E.; Hugg, Timo T.; Jaakkola, Jouni J. K.

    2014-01-01

    Encouraging individuals to take action is important for the overall success of climate change mitigation. Campaigns promoting climate change mitigation could address particular groups of the population on the basis of what kind of mitigation actions the group is already taking. To increase the knowledge of such groups performing similar mitigation actions we conducted a population-based cross-sectional study in Finland. The study population comprised 1623 young adults who returned a self-administered questionnaire (response rate 64%). Our aims were to identify groups of people engaged in similar climate change mitigation actions and to study the gender differences in the grouping. We also determined if socio-demographic characteristics can predict group membership. We performed latent class analysis using 14 mitigation actions as manifest variables. Three classes were identified among men: the Inactive (26%), the Semi-active (63%) and the Active (11%) and two classes among women: the Semi-active (72%) and the Active (28%). The Active among both genders were likely to have mitigated climate change through several actions, such as recycling, using environmentally friendly products, preferring public transport, and conserving energy. The Semi-Active had most probably recycled and preferred public transport because of climate change. The Inactive, a class identified among men only, had very probably done nothing to mitigate climate change. Among males, being single or divorced predicted little involvement in climate change mitigation. Among females, those without tertiary degree and those with annual income €≥16801 were less involved in climate change mitigation. Our results illustrate to what extent young adults are engaged in climate change mitigation, which factors predict little involvement in mitigation and give insight to which segments of the public could be the audiences of targeted mitigation campaigns. PMID:25054549

  9. Voluntary climate change mitigation actions of young adults: a classification of mitigators through latent class analysis.

    PubMed

    Korkala, Essi A E; Hugg, Timo T; Jaakkola, Jouni J K

    2014-01-01

    Encouraging individuals to take action is important for the overall success of climate change mitigation. Campaigns promoting climate change mitigation could address particular groups of the population on the basis of what kind of mitigation actions the group is already taking. To increase the knowledge of such groups performing similar mitigation actions we conducted a population-based cross-sectional study in Finland. The study population comprised 1623 young adults who returned a self-administered questionnaire (response rate 64%). Our aims were to identify groups of people engaged in similar climate change mitigation actions and to study the gender differences in the grouping. We also determined if socio-demographic characteristics can predict group membership. We performed latent class analysis using 14 mitigation actions as manifest variables. Three classes were identified among men: the Inactive (26%), the Semi-active (63%) and the Active (11%) and two classes among women: the Semi-active (72%) and the Active (28%). The Active among both genders were likely to have mitigated climate change through several actions, such as recycling, using environmentally friendly products, preferring public transport, and conserving energy. The Semi-Active had most probably recycled and preferred public transport because of climate change. The Inactive, a class identified among men only, had very probably done nothing to mitigate climate change. Among males, being single or divorced predicted little involvement in climate change mitigation. Among females, those without tertiary degree and those with annual income €≥16801 were less involved in climate change mitigation. Our results illustrate to what extent young adults are engaged in climate change mitigation, which factors predict little involvement in mitigation and give insight to which segments of the public could be the audiences of targeted mitigation campaigns.

  10. Regulation of MIR165/166 by class II and class III homeodomain leucine zipper proteins establishes leaf polarity

    PubMed Central

    Merelo, Paz; Ram, Hathi; Pia Caggiano, Monica; Ohno, Carolyn; Ott, Felix; Straub, Daniel; Graeff, Moritz; Cho, Seok Keun; Yang, Seong Wook; Wenkel, Stephan; Heisler, Marcus G.

    2016-01-01

    A defining feature of plant leaves is their flattened shape. This shape depends on an antagonism between the genes that specify adaxial (top) and abaxial (bottom) tissue identity; however, the molecular nature of this antagonism remains poorly understood. Class III homeodomain leucine zipper (HD-ZIP) transcription factors are key mediators in the regulation of adaxial–abaxial patterning. Their expression is restricted adaxially during early development by the abaxially expressed microRNA (MIR)165/166, yet the mechanism that restricts MIR165/166 expression to abaxial leaf tissues remains unknown. Here, we show that class III and class II HD-ZIP proteins act together to repress MIR165/166 via a conserved cis-element in their promoters. Organ morphology and tissue patterning in plants, therefore, depend on a bidirectional repressive circuit involving a set of miRNAs and its targets. PMID:27698117

  11. Multi-class Mode of Action Classification of Toxic Compounds Using Logic Based Kernel Methods.

    PubMed

    Lodhi, Huma; Muggleton, Stephen; Sternberg, Mike J E

    2010-09-17

    Toxicity prediction is essential for drug design and development of effective therapeutics. In this paper we present an in silico strategy, to identify the mode of action of toxic compounds, that is based on the use of a novel logic based kernel method. The technique uses support vector machines in conjunction with the kernels constructed from first order rules induced by an Inductive Logic Programming system. It constructs multi-class models by using a divide and conquer reduction strategy that splits multi-classes into binary groups and solves each individual problem recursively hence generating an underlying decision list structure. In order to evaluate the effectiveness of the approach for chemoinformatics problems like predictive toxicology, we apply it to toxicity classification in aquatic systems. The method is used to identify and classify 442 compounds with respect to the mode of action. The experimental results show that the technique successfully classifies toxic compounds and can be useful in assessing environmental risks. Experimental comparison of the performance of the proposed multi-class scheme with the standard multi-class Inductive Logic Programming algorithm and multi-class Support Vector Machine yields statistically significant results and demonstrates the potential power and benefits of the approach in identifying compounds of various toxic mechanisms.

  12. 77 FR 39653 - Proposed Establishment of Class E Airspace; Reidsville, GA, and Proposed Amendment of Class E...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a... continues to read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3... Airspace at Reidsville, GA. Separation of existing Class E airspace surrounding Swinton Smith Field...

  13. 75 FR 4268 - Establishment of Class D and E Airspace and Modification of Class E Airspace; State College, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-27

    ... modifying Class E airspace at University Park Airport, State College, PA (74 FR 54763). A newly commissioned... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The...

  14. 78 FR 21084 - Proposed Amendment of Class D and E Airspace, and Establishment of Class E Airspace; Oceana NAS, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-09

    ... Traffic Control Tower at Oceana NAS (Apollo Soucek Field) operating on a part time basis. This action... contact the FAA's Office of Rulemaking, (202) 267-9677, to request a copy of Advisory circular No. 11-2A... (Apollo Soucek Field), VA. The Air Traffic Control Tower at Oceana NAS is transitioning from a full...

  15. Defending the next round of non-profit hospital class action lawsuits.

    PubMed

    Olson, Mark D

    2005-01-01

    Recent controversies surrounding how not-for-profit hospitals price to and collect from the uninsured have resulted in class action lawsuits, investigations by state attorneys general, and other governmental investigations. The author argues that oversight at the hospital governing board level has been lax and sets forth a series of specific steps that hospital boards should take to deal with these controversies whether or not their specific hospital or hospital system has been investigated or sued. PMID:18973003

  16. 7 CFR 1940.318 - Completing environmental assessments for Class II actions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...; the dedication of environmentally sensitive areas which would otherwise be adversely affected by the...-disturbing activities; the establishment of vegetative buffer zones between project sites and adjacent land... action has the potential for significantly affecting the quality of the human environment or...

  17. Establishing auditory stimulus control over an eight-member equivalence class via conditional discrimination procedures.

    PubMed Central

    Saunders, R R; Wachter, J; Spradlin, J E

    1988-01-01

    Two eight-member equivalence classes of visual stimuli were established during three phases of a training program. In Phase 1, two training arrangements were compared. In one, 3 subjects were taught on different trials to select from a single pair of comparison stimuli (A1, A2) in response to eight sample stimuli that were trained in pairs (B1, B2; C1, C2; D1, D2; E1, E2). In the second arrangement, subjects were taught to select from four pairs of comparisons (B1, B2; C1, C2; D3, D2; E2, E2) in response to two samples (A1, A2). Training with the single pair of comparison stimuli resulted in the development of equivalence relations (B1C1, B2C2, D1B1, D2B2, B1E1, B2E2, C1D1, C2D2, C1E1, C2E2, D1E1, D2E2, and their reciprocals) between the sample stimuli without direct training of these relations. In the other training arrangement, these relations among the comparison stimuli developed in the performance of 1 subject only. In Phase 2, three new pairs of stimuli (F1, F2; G1, G2; H1, H2) were substituted for three of the original pairs (B1, B2; C1, C2; D1, D2) and the training arrangements for the groups were reversed. Following training, the performances that showed equivalence relations on the probes in the first phase also showed equivalence relations in the second phase. If such relations did not develop in the first phase, they did not do so in the second phase. In Phase 3, relations between stimuli across the two previous phases (e.g., B1F1, B2F2, B1G1, B2H2, C1F1, etc.) were investigated. The 4 subjects whose performances showed the development of these relations were taught to select one stimulus from each class (E1 and E2) in response to a verbal label (I1 and I2) and then were tested to see if the verbal label controlled responding to the remaining members of the class (e.g., I1A1, I2A2, I1B1, I2B2, etc.). For 3 subjects, this generalized control occurred; for the 4th, generalization occurred only after verbal training with a second pair of visual stimuli (F1

  18. 76 FR 49388 - Proposed Establishment of Class E Airspace; Tatitlek, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-10

    ... 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034... AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM). SUMMARY... instrument approach procedure at the Tatitlek Airport has made this action necessary to enhance safety...

  19. Action research to promote medical students' motivation in an English for Specific Purposes class.

    PubMed

    Dehnad, Afsaneh; Nasser, Hayedeh

    2014-01-01

    Action research is an attempt to seek immediate solutions to the problems experienced in educational settings. In this type of research, teachers are the researchers who intend to make instant reforms to develop, and improve their teaching styles and reflect on pedagogical practices. The purpose of this study was to conduct an action research to tackle the problem of students' low motivation in English classes at the medical school of Iran University of Medical Sciences in fall 2010. Participants of this study were 98 third-semester ESP students of medicine. To reform the situation and promote students' motivation to participate in classes more actively and eagerly, the researchers changed the syllabus by applying Kemmis and McTaggart's (1988) cyclical model of action research, and adopting task-based teaching. Data was collected by means of interviews with both teachers and students to determine the changes to be made in the syllabus, classroom observations to monitor students' behavioral changes, and a questionnaire to assess students' attitudes towards the changes. This research study had a number of valuable outcomes the most important of which was a change in classroom behavior of the students. PMID:25130157

  20. Action research to promote medical students' motivation in an English for Specific Purposes class.

    PubMed

    Dehnad, Afsaneh; Nasser, Hayedeh

    2014-01-01

    Action research is an attempt to seek immediate solutions to the problems experienced in educational settings. In this type of research, teachers are the researchers who intend to make instant reforms to develop, and improve their teaching styles and reflect on pedagogical practices. The purpose of this study was to conduct an action research to tackle the problem of students' low motivation in English classes at the medical school of Iran University of Medical Sciences in fall 2010. Participants of this study were 98 third-semester ESP students of medicine. To reform the situation and promote students' motivation to participate in classes more actively and eagerly, the researchers changed the syllabus by applying Kemmis and McTaggart's (1988) cyclical model of action research, and adopting task-based teaching. Data was collected by means of interviews with both teachers and students to determine the changes to be made in the syllabus, classroom observations to monitor students' behavioral changes, and a questionnaire to assess students' attitudes towards the changes. This research study had a number of valuable outcomes the most important of which was a change in classroom behavior of the students.

  1. 77 FR 37362 - Implementation of the Middle Class Tax Relief and Job Creation Act of 2012; Establishment of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-21

    ... COMMISSION 47 CFR Parts 1 and 64 Implementation of the Middle Class Tax Relief and Job Creation Act of 2012... Relief and Job Creation Act of 2012'' (Tax Relief Act). Specifically, section 6507 of the Tax Relief Act... establishment and ongoing management of the PSAP registry. The proposed rules are designed to address...

  2. Establishing a Telementoring Program that Can Be Used in Vocational Classes.

    ERIC Educational Resources Information Center

    Wheeldon, Robert Sean; Lehmann, Jean P.

    1999-01-01

    Describes an existing telementoring project formed between a large computer-based company and a transition class in a small rural high school and provides information about the steps necessary to implement such a program. (Author)

  3. Summer Site Visits 95. Workplace Education Class Establishes Innovative Networking between Casco Bay Partners.

    ERIC Educational Resources Information Center

    University of Southern Maine, Gorham.

    Employees of Hannaford Brothers Company, Nichols Portland, and Wood Structures in the Casco Bay area of Maine participated in a series of tours at each worksite for three consecutive Tuesdays in August 1995. Each group of employees, some of whom were limited English speakers engaged in workplace literacy classes, planned a tour of their facility,…

  4. Establishing Response and Stimulus Classes for Initiating Joint Attention in Children with Autism

    ERIC Educational Resources Information Center

    Jones, Emily A.

    2009-01-01

    The absence of the fundamental skill of "initiating joint attention" reflects the social-communicative impairment characterizing autism. Initiating joint attention is related to social and communication development as well as intervention outcomes for children with autism. A behaviorally based intervention was used to teach an expanded class of…

  5. 78 FR 18264 - Proposed Establishment of Class E Airspace; Tobe, CO

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... under control of Denver and Albuquerque Air Route Traffic Control Centers (ARTCCs). The FAA is proposing...: PART 71--DESIGNATION OF CLASS A, B, C, D AND E AIRSPACE AREAS; AIR TRAFFIC SERVICE ROUTES; AND.../airports_airtraffic/air_traffic/publications/airspace_amendments/ . You may review the public...

  6. 78 FR 18268 - Proposed Establishment of Class E Airspace; Blue Mesa, CO

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... (IFR) aircraft under control of Denver and Albuquerque Air Route Traffic Control Centers (ARTCCs). The... OF CLASS A, B, C, D AND E AIRSPACE AREAS; AIR TRAFFIC SERVICE ROUTES; AND REPORTING POINTS 0 1. The... http://www.faa.gov/airports_airtraffic/air_traffic/publications/airspace_amendments/ . You may...

  7. Exploring Possible Selves in a First-Year Physics Foundation Class: Engaging Students by Establishing Relevance

    ERIC Educational Resources Information Center

    Bennett, Dawn; Roberts, Lynne; Creagh, Christine

    2016-01-01

    Students often complain that they cannot see the relevance of what they are being taught in foundation physics classes. While revising and adjusting the curriculum and teaching are important, this study suggests it might also be useful to help students view their learning in relation to their future career aspirations. This paper reports on a…

  8. 76 FR 73505 - Establishment of Class E Airspace; Danville Airport, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-29

    ... Class E airspace at Danville, PA, to accommodate new Area Navigation (RNAV) Global Positioning System..., Operations Support Group, Eastern Service Center, Federal Aviation Administration, P.O. Box 20636, Atlanta... Danville, PA (76 FR 54155). Interested parties were invited to participate in this rulemaking effort...

  9. 77 FR 12760 - Proposed Establishment of Class E Airspace; Wilkes-Barre, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-02

    ... Airport, Wilkes-Barre, PA (76 FR 38585). Subsequent to publication the FAA found that Class E airspace..., the proposed rule published July 1, 2011 (76 FR 38585), is withdrawn. FOR FURTHER INFORMATION CONTACT..., 1, 2011 (76 FR 38585) (FR Doc. 2011-16664), is hereby withdrawn. Authority: 49 U.S.C. 106(g);...

  10. Exploring perception-action relations in music production: The asymmetric effect of tonal class.

    PubMed

    Jebb, Andrew T; Pfordresher, Peter Q

    2016-05-01

    When playing musical passages, performers integrate the pitch content of auditory feedback with current action plans. However, this process depends on the degree to which the musical structure of the feedback melody is perceived as similar to the structure of what is planned. Four experiments reported here explored the relationship between the tonal class of planned melodies (tonal or atonal) and the sequence of events formed by auditory feedback. Participants produced short melodies from memory that were either tonal (Experiments 1 and 3) or atonal (Experiments 2 and 4). Auditory feedback matched the planned melody with respect to contour but could vary in tonal class. The results showed that when participants planned a tonal melody, atonal feedback was treated as unrelated to the planned sequence. However, when planning an atonal melody, tonal feedback was still treated as similar to the planned sequence. This asymmetric similarity mirrors findings found within the music perception literature and implies that schematic musical knowledge is highly active in determining perception-action relations during music performance. PMID:26594878

  11. Exploring perception-action relations in music production: The asymmetric effect of tonal class.

    PubMed

    Jebb, Andrew T; Pfordresher, Peter Q

    2016-05-01

    When playing musical passages, performers integrate the pitch content of auditory feedback with current action plans. However, this process depends on the degree to which the musical structure of the feedback melody is perceived as similar to the structure of what is planned. Four experiments reported here explored the relationship between the tonal class of planned melodies (tonal or atonal) and the sequence of events formed by auditory feedback. Participants produced short melodies from memory that were either tonal (Experiments 1 and 3) or atonal (Experiments 2 and 4). Auditory feedback matched the planned melody with respect to contour but could vary in tonal class. The results showed that when participants planned a tonal melody, atonal feedback was treated as unrelated to the planned sequence. However, when planning an atonal melody, tonal feedback was still treated as similar to the planned sequence. This asymmetric similarity mirrors findings found within the music perception literature and implies that schematic musical knowledge is highly active in determining perception-action relations during music performance.

  12. 75 FR 81518 - Proposed Establishment of Class E Airspace; Wolfeboro, NH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ...) serving Huggins Hospital Heliport. This action would enhance the safety and airspace management of... Docket Management System (see ADDRESSES section for address and phone number). You may also submit... instrument approach procedures for Huggins Hospital Heliport. Controlled airspace extending upward from...

  13. 75 FR 81516 - Proposed Establishment of Class E Airspace; Colebrook, NH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ... Procedure (SIAP) serving the Upper Connecticut Valley Hospital Heliport. This action would enhance the safety and airspace management of Instrument Flight Rules (IFR) operations within the National Airspace... triplicate to the Docket Management System (see ADDRESSES section for address and phone number). You may...

  14. 75 FR 14383 - Proposed Establishment of Class E Airspace; Lucin, UT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-25

    ... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR... follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp... (IFR) traffic from en route airspace to Salt Lake City, UT. This action would enhance the safety...

  15. 75 FR 41774 - Proposed Establishment and Modification of Class E Airspace; Deer Park, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR... continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3...; Deer Park, WA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed...

  16. 76 FR 1380 - Proposed Establishment of Class E Airspace; Creighton, NE

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-10

    ... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of... continues to read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3...; Creighton, NE AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed...

  17. 76 FR 7515 - Proposed Establishment of Class E Airspace; Kenbridge, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-10

    ... AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM... proposed rule published November 29, 2010, at 75 FR 73016, is withdrawn. FOR FURTHER INFORMATION CONTACT.... Box 20636, Atlanta, Georgia 30320; telephone (404) 305-5588. SUPPLEMENTARY INFORMATION: History...

  18. 77 FR 71367 - Proposed Establishment of Class E Airspace; Round Mountain, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-30

    ...; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February.... 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The... Mountain, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed...

  19. 78 FR 45477 - Proposed Establishment of Class E Airspace; Akutan, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-29

    ... this action may be changed in light of comments received. All comments submitted will be available for... Regulatory Policies and Procedures (44 ] FR 11034; February 26, 1979); and (3) does not warrant preparation of a regulatory evaluation as the anticipated impact is so minimal. Since this is a routine...

  20. 78 FR 48081 - Proposed Establishment of Class E Airspace; McConnellsburg, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-07

    ... not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389..., PA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking...

  1. 76 FR 38585 - Proposed Establishment of Class E Airspace; Wilkes-Barre, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-01

    ... not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26... read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959..., PA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking...

  2. 75 FR 73016 - Proposed Establishment of Class E Airspace; Kenbridge, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-29

    ... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does.... 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The... AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM)....

  3. 76 FR 26658 - Proposed Establishment of Class E Airspace; Ranger, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-09

    ...; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February.... 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The... AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM)....

  4. 75 FR 65254 - Proposed Establishment of Class E Airspace; Benton, IL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-22

    ... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does..., 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The incorporation by reference in 14 CFR 71... AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM)....

  5. 77 FR 17363 - Proposed Establishment of Class E Airspace; West Memphis, AR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-26

    ... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does... continues to read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3..., AR AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking...

  6. 75 FR 53876 - Proposed Establishment of Class E Airspace; Berryville, AR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-02

    ...; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February.... 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The... Airspace; Berryville, AR AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of...

  7. 10 CFR 1021.410 - Application of categorical exclusions (classes of actions that normally do not require EAs or EISs).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... proposal is not connected to other actions with potentially significant impacts (40 CFR 1508.25(a)(1)), is... similar types of development in the vicinity of the proposed action, and expected outputs of emissions or... 10 Energy 4 2013-01-01 2013-01-01 false Application of categorical exclusions (classes of...

  8. Fermi Establishes Classical Novae as a Distinct Class of Gamma-ray Sources

    NASA Technical Reports Server (NTRS)

    Ackermann, M.; Ajello, M.; Albert, A.; Baldini, L.; Ballet, J.; Bastieri, D.; Bellazzini, R.; Bissaldi, E.; Blandford, R. D.; Bloom, E. D.; Bottacini, E.; Brandt, T. J.; Bregeon, J.; Bruel, P.; Buehler, R.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Caragiulo, M.; Caraveo, P. A.; Ferrara, E. C.; Harding, A. K.; Hays, E.; Perkins, J. S.; Thompson, D. J.

    2014-01-01

    A classical nova results from runaway thermonuclear explosions on the surface of a white dwarf that accretes matter from a low-mass main-sequence stellar companion. In 2012 and 2013, three novae were detected in gamma rays and stood in contrast to the first gamma-ray detected nova V407 Cygni 2010, which belongs to a rare class of symbiotic binary systems. Despite likely differences in the compositions and masses of their white dwarf progenitors, the three classical novae are similarly characterized as soft spectrum transient gamma-ray sources detected over 2-3 week durations. The gamma-ray detections point to unexpected high-energy particle acceleration processes linked to the mass ejection from thermonuclear explosions in an unanticipated class of Galactic gamma-ray sources.

  9. Novae. Fermi establishes classical novae as a distinct class of gamma-ray sources.

    PubMed

    2014-08-01

    A classical nova results from runaway thermonuclear explosions on the surface of a white dwarf that accretes matter from a low-mass main-sequence stellar companion. In 2012 and 2013, three novae were detected in γ rays and stood in contrast to the first γ-ray-detected nova V407 Cygni 2010, which belongs to a rare class of symbiotic binary systems. Despite likely differences in the compositions and masses of their white dwarf progenitors, the three classical novae are similarly characterized as soft-spectrum transient γ-ray sources detected over 2- to 3-week durations. The γ-ray detections point to unexpected high-energy particle acceleration processes linked to the mass ejection from thermonuclear explosions in an unanticipated class of Galactic γ-ray sources. PMID:25082700

  10. Rheological and molecular weight comparisons of approved hyaluronic acid products - preliminary standards for establishing class III medical device equivalence.

    PubMed

    Braithwaite, Gavin J C; Daley, Michael J; Toledo-Velasquez, David

    2016-01-01

    Hyaluronic acid of various molecular weights has been in use for the treatment of osteoarthritis knee pain for decades. Worldwide, these products are regulated as either as drugs or devices and in some countries as both. In the US, this class of products is regulated as Class III medical devices, which places specific regulatory requirements on developers of these materials under a Pre-Market Approval process, typically requiring data from prospective randomized controlled clinical studies. In 1984 pharmaceutical manufacturers became able to file an Abbreviated New Drug Application for approval of a generic drug, thus establishing standards for demonstrating equivalence to an existing chemical entity. Recently, the first biosimilar, or 'generic biologic', was approved. Biosimilars are biological products that are approved by the FDA because they are 'highly similar' to a reference product, and have been shown to have no clinically meaningful differences from the reference product. For devices, Class II medical devices have a pathway for declaring equivalence to an existing product by filing a 510 k application for FDA clearance. However, until recently no equivalent regulatory pathway was available to Class III devices. In this paper, we consider the critical mechanical performance parameters for intra-articular hyaluronic products to demonstrate indistinguishable characteristics. Analogous to the aforementioned pathways that allow for a demonstration of equivalence, we examine these parameters for an existing, marketed device and compare molecular weight and rheological properties of multiple batches of a similar product. We propose that this establishes a scientific rationale for establishing Class III medical device equivalence.

  11. 76 FR 40797 - Establishment of Class E Airspace; Lincoln City, OR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-12

    ... System (GPS) standard instrument approach procedures at Samaritan North Lincoln Hospital Heliport. This... management of Instrument Flight Rules (IFR) operations. DATES: Effective date, 0901 UTC, October 20, 2011... rulemaking to establish controlled airspace at Lincoln City, OR (76 FR 21268). Interested parties...

  12. 75 FR 226 - Establishment of Class E Airspace; Riverside/Rubidoux Flabob Airport, Riverside, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-05

    ... establish controlled airspace at Riverside/Rubidoux Flabob Airport, Riverside, CA (74 FR 52704). Interested... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does.... 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in...

  13. 78 FR 34554 - Establishment of Class E Airspace; Blue Mesa, CO

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    ...: History On March 26, 2013, the FAA published in the Federal Register a notice of proposed rulemaking (NPRM) to establish controlled airspace at Blue Mesa, CO (78 FR 18268). Interested parties were invited to... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44...

  14. 78 FR 65556 - Establishment of Class E Airspace; Cut Bank, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-01

    ... Salt Lake City and Seattle Air Route Traffic Control Centers (ARTCCs). This improves the safety and... airspace at the Cut Bank VHF Omni-Directional Radio Range Tactical Air Navigational Aid (VORTAC) navigation... proposed rulemaking (NPRM) to establish controlled airspace at Cut Bank, MT (78 FR 45474)....

  15. 77 FR 49720 - Establishment of Class E Airspace; Chenega Bay, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-17

    ... proposed rulemaking (NPRM) to establish controlled airspace at Chenega Bay, AK (77 FR 31548). Interested... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a...: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E. O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p....

  16. 78 FR 76055 - Establishment of Class E Airspace; Donlin Creek, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-16

    ... rulemaking (NPRM) to establish controlled airspace at Donlin Creek, AK (78 FR 58490). Interested parties were...'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant... FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in 14 CFR...

  17. 78 FR 38197 - Establishment of Class E Airspace; Port Townsend, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ... establish controlled airspace at Port Townsend, WA (78 FR 25005). Interested parties were invited to... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The...

  18. 75 FR 63066 - Establishment of Class E Airspace; Clifton/Morenci, AZ

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-14

    ... establish controlled airspace at Clifton/Morenci, AZ (75 FR 44725). Interested parties were invited to... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a... follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E. O. 10854, 24 FR 9565, 3 CFR, 1959-1963...

  19. 16 CFR 1009.8 - Policy on establishing priorities for Commission action.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... eliminated through commission action. (3) Chronic illness and future injuries. Certain products, although not.... Although not as susceptible to measurements as other product related injuries and illnesses, these risks... predicted future illnesses and injuries and the effectiveness of Commission action in reducing...

  20. 16 CFR 1009.8 - Policy on establishing priorities for Commission action.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... eliminated through commission action. (3) Chronic illness and future injuries. Certain products, although not.... Although not as susceptible to measurements as other product related injuries and illnesses, these risks... predicted future illnesses and injuries and the effectiveness of Commission action in reducing...

  1. 16 CFR 1009.8 - Policy on establishing priorities for Commission action.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... eliminated through commission action. (3) Chronic illness and future injuries. Certain products, although not.... Although not as susceptible to measurements as other product related injuries and illnesses, these risks... predicted future illnesses and injuries and the effectiveness of Commission action in reducing...

  2. 16 CFR 1009.8 - Policy on establishing priorities for Commission action.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... eliminated through commission action. (3) Chronic illness and future injuries. Certain products, although not.... Although not as susceptible to measurements as other product related injuries and illnesses, these risks... predicted future illnesses and injuries and the effectiveness of Commission action in reducing...

  3. 16 CFR 1009.8 - Policy on establishing priorities for Commission action.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... eliminated through commission action. (3) Chronic illness and future injuries. Certain products, although not.... Although not as susceptible to measurements as other product related injuries and illnesses, these risks... predicted future illnesses and injuries and the effectiveness of Commission action in reducing...

  4. Exploring possible selves in a first-year physics foundation class: Engaging students by establishing relevance

    NASA Astrophysics Data System (ADS)

    Bennett, Dawn; Roberts, Lynne; Creagh, Christine

    2016-06-01

    Students often complain that they cannot see the relevance of what they are being taught in foundation physics classes. While revising and adjusting the curriculum and teaching are important, this study suggests it might also be useful to help students view their learning in relation to their future career aspirations. This paper reports on a study conducted with first-year students enrolled in a compulsory foundation physics unit with a history of low pass rates. Working within a "possible selves" framework, activities were designed to help students position their learning in relation to possible future lives and careers. Two cohorts of students (N =93 ) engaged in an intensive workshop comprising multiple activities relating to self and career. Self-reflection worksheets were analyzed using content analysis. The results indicate that students experience immediate benefits from these activities through self-reflection on the current self, future possible professional selves, and the role of current studies in narrowing the gap between the two.

  5. Global Mapping of Traditional Chinese Medicine into Bioactivity Space and Pathways Annotation Improves Mechanistic Understanding and Discovers Relationships between Therapeutic Action (Sub)classes

    PubMed Central

    Mohamad Zobir, Siti Zuraidah; Mohd Fauzi, Fazlin; Liggi, Sonia; Drakakis, Georgios; Fu, Xianjun; Fan, Tai-Ping; Bender, Andreas

    2016-01-01

    Traditional Chinese medicine (TCM) still needs more scientific rationale to be proven for it to be accepted further in the West. We are now in the position to propose computational hypotheses for the mode-of-actions (MOAs) of 45 TCM therapeutic action (sub)classes from in silico target prediction algorithms, whose target was later annotated with Kyoto Encyclopedia of Genes and Genomes pathway, and to discover the relationship between them by generating a hierarchical clustering. The results of 10,749 TCM compounds showed 183 enriched targets and 99 enriched pathways from Estimation Score ≤ 0 and ≥ 5% of compounds/targets in a (sub)class. The MOA of a (sub)class was established from supporting literature. Overall, the most frequent top three enriched targets/pathways were immune-related targets such as tyrosine-protein phosphatase nonreceptor type 2 (PTPN2) and digestive system such as mineral absorption. We found two major protein families, G-protein coupled receptor (GPCR), and protein kinase family contributed to the diversity of the bioactivity space, while digestive system was consistently annotated pathway motif, which agreed with the important treatment principle of TCM, “the foundation of acquired constitution” that includes spleen and stomach. In short, the TCM (sub)classes, in many cases share similar targets/pathways despite having different indications. PMID:26989424

  6. Global Mapping of Traditional Chinese Medicine into Bioactivity Space and Pathways Annotation Improves Mechanistic Understanding and Discovers Relationships between Therapeutic Action (Sub)classes.

    PubMed

    Mohamad Zobir, Siti Zuraidah; Mohd Fauzi, Fazlin; Liggi, Sonia; Drakakis, Georgios; Fu, Xianjun; Fan, Tai-Ping; Bender, Andreas

    2016-01-01

    Traditional Chinese medicine (TCM) still needs more scientific rationale to be proven for it to be accepted further in the West. We are now in the position to propose computational hypotheses for the mode-of-actions (MOAs) of 45 TCM therapeutic action (sub)classes from in silico target prediction algorithms, whose target was later annotated with Kyoto Encyclopedia of Genes and Genomes pathway, and to discover the relationship between them by generating a hierarchical clustering. The results of 10,749 TCM compounds showed 183 enriched targets and 99 enriched pathways from Estimation Score ≤ 0 and ≥ 5% of compounds/targets in a (sub)class. The MOA of a (sub)class was established from supporting literature. Overall, the most frequent top three enriched targets/pathways were immune-related targets such as tyrosine-protein phosphatase nonreceptor type 2 (PTPN2) and digestive system such as mineral absorption. We found two major protein families, G-protein coupled receptor (GPCR), and protein kinase family contributed to the diversity of the bioactivity space, while digestive system was consistently annotated pathway motif, which agreed with the important treatment principle of TCM, "the foundation of acquired constitution" that includes spleen and stomach. In short, the TCM (sub)classes, in many cases share similar targets/pathways despite having different indications.

  7. What Is My Role? Establishing Teacher and Youth Worker Responsibilities in Social Action Projects

    ERIC Educational Resources Information Center

    Epstein, Shira Eve

    2013-01-01

    In this research, I analyze the roles of teachers and youth workers from a community-based organization in the context of two high school social action projects. Both the teachers and the youth workers assumed distinct roles while working together during the civic project enactments. The teachers were largely positioned as responsible for…

  8. 78 FR 68020 - Evaluation of Established Plant Pests for Action at Ports of Entry

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE... Secretary of Agriculture is authorized to take such actions as may be necessary to prevent the introduction... markets), agricultural production, and the environment; The scientific knowledge we have about the...

  9. The QUIPPED Project: Exploring Relevance and Rigor of Action Research Using Established Principles and Criteria

    ERIC Educational Resources Information Center

    Chapman, Christine; Paterson, Margo; Medves, Jennifer M.

    2011-01-01

    This paper is the last in a series of three manuscripts published in the TQR journal over the past few years. This work is part of a larger program of research that has been carried out by a team of researchers detailing various aspects of a three year action research project carried out from 2005 and 2008. This particular paper addresses issues…

  10. A Sound Research Base for Beginning Teacher Education: Robust Hope, Action Policy Analysis and "Top of the Class"

    ERIC Educational Resources Information Center

    Singh, Michael

    2007-01-01

    This paper focuses on the recommendations of "Top of the class," the February 2007 report of an inquiry into teacher education conducted by the Australian House of Representatives Standing Committee on Education and Vocational Training. To do this action policy analysis, it presents Raymond Williams' dictum of "making hope practical" through five…

  11. Economic Affirmative Action in College Admissions: A Progressive Alternative to Racial Preferences and Class Rank Admissions Plans. Issue Brief Series.

    ERIC Educational Resources Information Center

    Kahlenberg, Richard

    This brief explores the pros and cons of three alternative approaches to college admissions policies: race-based preferences, which are backed by most Democrats; class-rank plans (admitting the top students in each high school), which is backed by the Bush administration; and economic affirmative action for the disadvantaged of all races, which…

  12. 10 CFR Appendix C to Subpart D of... - Classes of Actions That Normally Require EAS but not Necessarily EISs

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... resource, hydropower, geothermal, fossil fuel, biomass, and solar energy, but excluding nuclear). For... 10 Energy 4 2012-01-01 2012-01-01 false Classes of Actions That Normally Require EAS but not Necessarily EISs C Appendix C to Subpart D of Part 1021 Energy DEPARTMENT OF ENERGY (GENERAL...

  13. 10 CFR Appendix C to Subpart D of... - Classes of Actions that Normally Require EAs but not Necessarily EISs

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... resource, hydropower, geothermal, fossil fuel, biomass, and solar energy, but excluding nuclear). For... 10 Energy 4 2013-01-01 2013-01-01 false Classes of Actions that Normally Require EAs but not Necessarily EISs C Appendix C to Subpart D of Part 1021 Energy DEPARTMENT OF ENERGY (GENERAL...

  14. 10 CFR Appendix C to Subpart D of... - Classes of Actions that Normally Require EAs but not Necessarily EISs

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... to, wind resource, hydropower, geothermal, fossil fuel, biomass, and solar energy, but excluding... 10 Energy 4 2014-01-01 2014-01-01 false Classes of Actions that Normally Require EAs but not Necessarily EISs C Appendix C to Subpart D of Part 1021 Energy DEPARTMENT OF ENERGY (GENERAL...

  15. Implementing the Affordable Care Act: State Action to Establish SHOP Marketplaces.

    PubMed

    Dash, Sarah J; Lucia, Kevin W; Thomas, Amy

    2014-03-01

    The Affordable Care Act seeks to help small employers offer coverage by reforming the small-group market and establishing Small Business Health Options Program (SHOP) marketplaces. Seventeen states and the District of Columbia chose to operate their own SHOP marketplaces in 2014, with the federal government operating the SHOP marketplace in 33 states. This brief examines state decisions to enhance the value of SHOP marketplaces for small employers and finds that most have set predictable participation and eligibility requirements and will offer a competitive choice of insurers and plans. States also are seeking to facilitate small employers' shopping experience through online tools and access to personalized assistance. While not all SHOP marketplaces are yet functioning as intended, their establishment offers an opportunity to identify successful strategies for improving the affordability and accessibility of coverage for small employers. PMID:26259258

  16. [Successor establishment in familiy business as field of action in health promotion].

    PubMed

    Hetzel, C; Holzer, M

    2014-10-01

    Successor establishment in familiy business may lead to interpersonal and intrapsychological conflicts and is mostly a transition to retirement. This may have a negative impact on the senior's health. The "Sozialversicherung für Landwirtschaft, Forsten und Gartenbau (SVLFG)" reacts with an intervention of several days duration. Evaluation aim is measuring participants changes in specific activities and confidence on successor establishment and retirement indicating mental health stabilisation. The method comprises a panel of intervention group (I, n=61) and comparison group (V, n=28) randomly selected, structurally similar and parallelised to point of transfer. Retirement activities significantly rise in I (p=0.001, Cohen's d=0.48) and are steady in V (p=0.54) after one year. Level of confidence is equal in both groups and steady but strongly indicating response shift in I. Intervention activates targeted activities and improves confidence at least qualitatively in a field that has hardly been researched.

  17. Cyclooctadepsipeptides--an anthelmintically active class of compounds exhibiting a novel mode of action.

    PubMed

    Harder, Achim; Schmitt-Wrede, Hans-Peter; Krücken, Jürgen; Marinovski, Predrag; Wunderlich, Frank; Willson, James; Amliwala, Kiran; Holden-Dye, Lindy; Walker, Robert

    2003-09-01

    There are three major classes of anthelmintics for veterinary use: the benzimidazoles/prebenzimidazoles, the tetrahydropyrimidines/imidazothiazoles, and the macrocyclic lactones. In nematodes, there are five targets for the existing anthelmintics: the nicotinergic acetylcholine receptor which is the target of tetrahydropyrimidines/imidazothiazoles and indirectly that of the acetylcholineesterase inhibitors; the GABA receptor which is the target of piperazine, the glutamate-gated chloride channel as the target of the macrocyclic lactones, and beta-tubulin as the target of prebenzimidazoles/benzimidazoles. All these anthelmintics are now in serious danger because of the worldwide spread of resistant nematodes in sheep, cattle, horses and pigs. The class of cyclooctadepsipeptides has entered the scene of anthelmintic research in the early 1990s. PF1022A, the first anthelmintically active member, is a natural compound from the fungus Mycelia sterilia that belongs to the microflora of the leaves of the Camellia japonica. PF1022A contains 4 N-Methyl-L-leucines, 2 D-lactic acids and 2-D-phenyllactic acids arranged as a cyclic octadepsipeptide with an alternating L-D-L-configuration. Emodepside is a semisynthetic derivative of PF1022A with a morpholine ring at each of the two D-phenyllactic acids in para position. The anthelmintic activity is directed against gastrointestinal nematodes in chicken, mice, rats, meriones, dogs, cats, sheep, cattle and horses. Moreover, emodepside is active against Trichinella spiralis larvae in muscles, microfilariae and preadult filariae and Dictyocaulus viviparus. PF1022A and emodepside are fully effective against benzimidazole-, levamisole or ivermectin-resistant nematodes in sheep and cattle. In Ascaris suum both cyclooctadepsipeptides lead to paralysis indicating a neuropharmacological action of these compounds. Using a PF1022A-ligand immunoscreening of a cDNA library from Haemonchus contortus a cDNA clone of 3569 base pairs could be

  18. Middle- and Upper-Middle-Class Parent Action for Urban Public Schools: Promise or Paradox?

    ERIC Educational Resources Information Center

    Posey, Linn

    2012-01-01

    Background/Context: Recent trends suggest that middle-class parents may be a growing constituency in urban public schools and districts. Within the burgeoning literature on the middle class in urban public schools, most scholars have focused on parents' goals and orientations and/or the consequences of parental involvement in classroom and school…

  19. Evolution in Action, a Case Study Based Advanced Biology Class at Spelman College

    ERIC Educational Resources Information Center

    Pai, Aditi

    2009-01-01

    The Biology department at Spelman, a historically black women's college has undertaken a major curriculum revision in the last few years. A primary goal of this revision is to increase the breadth of topics in biology classes. Historically, classes in the areas of ecology and evolution have been underrepresented whereas Spelman has always offered…

  20. Factors modifying duration of drug action: a practical for large undergraduate classes on limited laboratory space, staff and budget.

    PubMed

    Kwanashie, K O; Amabeoku, G J; Auta, J

    1989-09-01

    A desperate need for health professionals is answered by yearly increases in university student admissions in many developing countries. Yet economic constraints dictate that subventions for teaching and research remain static or even decrease as student populations increase. Practical teaching, for example in pharmacology, is susceptible to inadequate funding because of the capital and recurrent expenditure needed to procure and maintain laboratories, staff, animals, instruments and chemicals. Class demonstrations, although they provide a partial answer to the problem, are beset with a number of disadvantages. Provision of good training on low funds demands ingenuity to modify teaching/learning processes while still achieving the desired objectives. This paper illustrates such a procedure by describing the logistics of a practical class on 'Factors modifying duration of drug action' to large classes of undergraduate medical and pharmacy students, on limited laboratory space, staff and budget'. A sample laboratory result is included.

  1. 78 FR 18246 - Implementation of the Middle Class Tax Relief and Job Creation Act of 2012; Establishment of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... COMMISSION 47 CFR Parts 1 and 64 Implementation of the Middle Class Tax Relief and Job Creation Act of 2012... information collection associated with the Commission's Implementation of the ] Middle Class Tax Relief and... authority for the information collection is found in the Middle Class Tax Relief and Job Creation Act...

  2. 77 FR 71131 - Implementation of the Middle Class Tax Relief and Job Creation Act of 2012; Establishment of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-29

    ... COMMISSION 47 CFR Parts 1 and 64 Implementation of the Middle Class Tax Relief and Job Creation Act of 2012... registry for public safety answering points (PSAPs) as required by the ``Middle Class Tax Relief and Job...) conforms to the RFA. A. Need for, and Objectives of, the Order 20. The ``Middle Class Tax Relief and...

  3. 7 CFR 1940.318 - Completing environmental assessments for Class II actions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... potential need for an EIS. When identified impacts are difficult to quantify (such as odor and visual and... effects is received after the assessment is completed but prior to the action's approval, such...

  4. 18 CFR 707.8 - Typical classes of action requiring similar treatment under NEPA.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Typical classes of... Resources WATER RESOURCES COUNCIL COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT (NEPA) Water... submittal of regional water resources management plans (comprehensive, coordinated, joint plans or...

  5. 18 CFR 707.8 - Typical classes of action requiring similar treatment under NEPA.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Typical classes of... Resources WATER RESOURCES COUNCIL COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT (NEPA) Water... submittal of regional water resources management plans (comprehensive, coordinated, joint plans or...

  6. Views and Workshops of a Master's Class in Intercultural Competence: Mill's Model of Intercultural Action

    ERIC Educational Resources Information Center

    Ioannitou, Gina

    2010-01-01

    This paper is the result of a participative process in which the students of the Master's Degree "Didactique des Langues" (foreign language didactics) at Universite du Maine (Le Mans, France) explored through whole-class activities the field of intercultural dialog and intercultural competence teaching. Our approach to intercultural teaching…

  7. The Facebook-in-Action: Challenging, Harnessing and Enhancing Students Class Assignments and Projects

    ERIC Educational Resources Information Center

    Saifudin, Adam Mohd; Yacob, Aizan; Saad, Rohaizah

    2016-01-01

    Issues of universities students harnessing and capitalizing the usage of Facebook for their own learning capabilities and effective thinking is always the focus of education scholars, in assessing the quality class assignments and projects produced by them. Therefore, Facebook is now becoming unbearable influence since the internet activation in…

  8. 78 FR 10099 - Implementation of the Middle Class Tax Relief and Job Creation Act of 2012; Establishment of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-13

    ... COMMISSION 47 CFR Part 1 Implementation of the Middle Class Tax Relief and Job Creation Act of 2012..., (77 FR 71131). The amended rules are necessary to implement the enforcement provisions of the Middle....; 47 U.S.C. 151, 154(i), 154(j), 155, 157, 225, 227, 303(r), and 309, the Middle Class Tax Relief...

  9. Inhibition of voltage-gated calcium channels as common mode of action for (mixtures of) distinct classes of insecticides.

    PubMed

    Meijer, Marieke; Dingemans, Milou M L; van den Berg, Martin; Westerink, Remco H S

    2014-09-01

    Humans are exposed to distinct structural classes of insecticides with different neurotoxic modes of action. Because calcium homeostasis is essential for proper neuronal function and development, we investigated the effects of insecticides from different classes (pyrethroid: (α-)cypermethrin; organophosphate: chlorpyrifos; organochlorine: endosulfan; neonicotinoid: imidacloprid) and mixtures thereof on the intracellular calcium concentration ([Ca(2+)]i). Effects of acute (20 min) exposure to (mixtures of) insecticides on basal and depolarization-evoked [Ca(2+)]i were studied in vitro with Fura-2-loaded PC12 cells and high resolution single-cell fluorescence microscopy. The data demonstrate that cypermethrin, α-cypermethrin, endosulfan, and chlorpyrifos concentration-dependently decreased depolarization-evoked [Ca(2+)]i, with 50% (IC50) at 78nM, 239nM, 250nM, and 899nM, respectively. Additionally, acute exposure to chlorpyrifos or endosulfan (10μM) induced a modest increase in basal [Ca(2+)]i, amounting to 68 ± 8nM and 53 ± 8nM, respectively. Imidacloprid did not disturb basal or depolarization-evoked [Ca(2+)]i at 10μM. Following exposure to binary mixtures, effects on depolarization-evoked [Ca(2+)]i were within the expected effect additivity range, whereas the effect of the tertiary mixture was less than this expected additivity effect range. These results demonstrate that different types of insecticides inhibit depolarization-evoked [Ca(2+)]i in PC12 cells by inhibiting voltage-gated calcium channels (VGCCs) in vitro at concentrations comparable with human occupational exposure levels. Moreover, the effective concentrations in this study are below those for earlier described modes of action. Because inhibition of VGCCs appears to be a common and potentially additive mode of action of several classes of insecticides, this target should be considered in neurotoxicity risk assessment studies.

  10. Putting Faith into Action: A Model for the North American Middle Class

    ERIC Educational Resources Information Center

    Clare, Roberta C.

    2006-01-01

    How do adult learners make the connection between ethical thinking and ethical action--between what they believe and how they act? This article explores implications for religious education for social justice based on a case study of transformative learning theory, Freirean pedagogy, and popular education principles. (Contains 8 footnotes.)

  11. Action!

    ERIC Educational Resources Information Center

    Senese, Joseph

    1998-01-01

    A small group of teachers at one Illinois high school is helping to effect and promote change. Through the Action Research Laboratory (ARL), teams of teachers conduct collaborative action research to improve classroom practices. Data from the first two years of the ARL indicate that teachers are eager to participate in, and have thrived in, their…

  12. Using Cooperative Learning 100% of the Time in Mathematics Classes Establishes a Student-Centered Interactive Learning Environment.

    ERIC Educational Resources Information Center

    Panitz, Theodore

    This paper describes one approach to implementing cooperative learning in mathematics classes virtually 100% of the time. By describing this maximum approach, it is hoped that teachers will be encouraged to try cooperative learning at least part of the time in their classrooms. Cooperative learning activities help identify widespread student…

  13. 78 FR 12967 - Establishment of Class A TV Service and Cable Television Rate Regulation; Cost of Service Rules...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-26

    ... for the sections listed: 73.1545(e)-66 FR 21681, May 1, 2001 76.922(i)(6)(i) and (i)(7)-61 FR 9367... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS... Communications Commission. ACTION: Final rule; clarification and announcement of effective dates. SUMMARY:...

  14. Acceleration of electrons under the action of petawatt-class laser pulses onto foam targets

    NASA Astrophysics Data System (ADS)

    Pugachev, L. P.; Andreev, N. E.; Levashov, P. R.; Rosmej, O. N.

    2016-09-01

    Optimization study for future experiments on interaction of petawatt laser pulses with foam targets was done by 3D PIC simulations. Densities in the range 0.5nc-nc and thicknesses in the range 100 - 500 μm of the targets were considered corresponding to those which are currently available. It is shown that heating of electrons mainly occurs under the action of the ponderomotive force of a laser pulse in which amplitude increases up to three times because of self-focusing effect in underdense plasma. Accelerated electrons gain additional energy directly from the high-frequency laser field at the betatron resonance in the emerging plasma density channels. For thicker targets a higher number of electrons with higher energies are obtained. The narrowing of the angular distribution of electrons for thicker targets is explained by acceleration in multiple narrow filaments. Obtained energies of accelerated electrons can be approximated by Maxwell distribution with the temperature 8.5 MeV. The charge carried by electrons with energies higher than 30 MeV is about 30 nC, that is 3-4 order of magnitude higher than the charge predicted by the ponderomotive scaling for the incident laser amplitude.

  15. 36 CFR Exhibit B to Part 906 - Guidelines for Establishing Strategy To Implement Affirmative Action Personnel Plan

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... affirmative action policy in advertisements and employment literature. (3) Utilization of minority media in... review of minority, female, Vietnam era veteran, and handcapped employees to identify underutilized...

  16. 36 CFR Exhibit B to Part 906 - Guidelines for Establishing Strategy To Implement Affirmative Action Personnel Plan

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... affirmative action policy in advertisements and employment literature. (3) Utilization of minority media in... review of minority, female, Vietnam era veteran, and handcapped employees to identify underutilized...

  17. Fungal laccase, cellobiose dehydrogenase, and chemical mediators: combined actions for the decolorization of different classes of textile dyes.

    PubMed

    Ciullini, Ilaria; Tilli, Silvia; Scozzafava, Andrea; Briganti, Fabrizio

    2008-10-01

    Dyes belonging to the mono-, di-, tri- and poly-azo as well as anthraquinonic and mono-azo Cr-complexed classes, chosen among the most utilized in textile applications, were employed for a comparative enzymatic decolorization study using the extracellular crude culture extracts from the white rot fungus Funalia (Trametes) trogii grown on different culture media and activators able to trigger different levels of expression of oxidizing enzymes: laccase and cellobiose dehydrogenase. Laccase containing extracts were capable to decolorize some dyes from all the different classes analyzed, whereas the recalcitrant dyes were subjected to the combined action of laccase and the chemical mediator HBT, or laccase plus cellobiose dehydrogenase. Correlations among the decolorization degree of the various dyes and their electronic and structural diversities were rationalized and discussed. The utilization of cellobiose dehydrogenase in support to the activity of laccase for the decolorization of azo textile dyes resulted in substantial increases in decolorization for all the refractory dyes proving to be a valid alternative to more expensive and less environmentally friendly chemical treatments of textile dyes wastes.

  18. Structure and mechanism of action of the hydroxy aryl aldehyde class of IRE1 endoribonuclease inhibitors

    PubMed Central

    Sanches, Mario; Duffy, Nicole M.; Talukdar, Manisha; Thevakumaran, Nero; Chiovitti, David; Canny, Marella D.; Lee, Kenneth; Kurinov, Igor; Uehling, David; Al-awar, Rima; Poda, Gennadiy; Prakesch, Michael; Wilson, Brian; Tam, Victor; Schweitzer, Colleen; Toro, Andras; Lucas, Julie L.; Vuga, Danka; Lehmann, Lynn; Durocher, Daniel; Zeng, Qingping; Patterson, John B.; Sicheri, Frank

    2014-01-01

    Endoplasmic reticulum (ER) stress activates the unfolded protein response and its dysfunction is linked to multiple diseases. The stress transducer IRE1α is a transmembrane kinase endoribonuclease (RNase) that cleaves mRNA substrates to re-establish ER homeostasis. Aromatic ring systems containing hydroxy-aldehyde moieties, termed hydroxy aryl aldehydes (HAA), selectively inhibit IRE1α RNase and thus represent a novel chemical series for therapeutic development. We solved crystal structures of murine IRE1α in complex with three HAA inhibitors. HAA inhibitors engage a shallow pocket at the RNase active site through pi-stacking interactions with His910 and Phe889, an essential Schiff base with Lys907 and a H-bond with Tyr892. Structure activity studies and mutational analysis of contact residues define the optimal chemical space of inhibitors and validate the inhibitor binding site. These studies lay the foundation for understanding both the biochemical and cellular functions of IRE1α using small molecule inhibitors and suggest new avenues for inhibitor design. PMID:25164867

  19. [An Affirmative Action Program to Redress Past Inequities and to Establish a Policy of Equal Treatment and Equal Opportunity at the University of Wisconsin for All Women.

    ERIC Educational Resources Information Center

    Wisconsin Univ., Madison.

    The Association of Faculty Women's proposals for an affirmative action program were developed by women who have expertise in the areas that are discussed. These areas include: establishment of an office for women; hiring and promotion goals; employment; professional, scientific and specialist academic staff; fringe benefits; university governance;…

  20. 36 CFR Exhibit B to Part 906 - Guidelines for Establishing Strategy To Implement Affirmative Action Personnel Plan

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Personnel Plan The following are suggested as the types of activities to be considered in the development of... affirmative action policy in advertisements and employment literature. (3) Utilization of minority media...

  1. The drug thief at Georgetown University Medical Center: anatomy of a $2 billion class-action lawsuit.

    PubMed

    2000-08-01

    Separate lawsuits filed on behalf of plaintiff patients at Georgetown University Medical Center, Washington, DC, have been consolidated under a District of Columbia judge who is scheduled to rule soon on whether to certify them as a class-action suit against the medical center. The case involves a drug-abusing worker in the interventional radiology unit at Georgetown University Hospital who may have exposed up to 500 patients to HIV, hepatitis, and other viruses during his period of employment from September 8, 1999 to February 2, 2000. The lawsuits allege that the med center failed to protect patients by not adopting American Hospital Association guidelines that call for universal pre-employment drug screening. The hospital currently is in the final stages of being sold to Medstar Health, Columbia, MD, which may eventually change the drug-screening policy. The episode not only has been embarrassing for the prestigious medical center, but also has focused attention on the potential consequences for hospitals that do not screen employees for drug use.

  2. Transmembrane peptides as unique tools to demonstrate the in vivo action of a cross-class GPCR heterocomplex.

    PubMed

    Lee, Leo T O; Ng, Stephanie Y L; Chu, Jessica Y S; Sekar, Revathi; Harikumar, Kaleeckal G; Miller, Laurence J; Chow, Billy K C

    2014-06-01

    Angiotensin (ANGII) and secretin (SCT) share overlapping, interdependent osmoregulatory functions in brain, where SCT peptide/receptor function is required for ANGII action, yet the molecular basis is unknown. Since receptors for these peptides (AT1aR, SCTR) are coexpressed in osmoregulatory centers, a possible mechanism is formation of a cross-class receptor heterocomplex. Here, we demonstrate such a complex and its functional importance to modulate signaling. Association of AT1aR with SCTR reduced ability of SCT to stimulate cyclic adenosine monophosphate (cAMP), with signaling augmented in presence of ANGII or constitutively active AT1aR. Several transmembrane (TM) peptides of these receptors were able to affect their conformation within complexes, reducing receptor BRET signals. AT1aR TM1 affected only formation and activity of the heterocomplex, without effect on homomers of either receptor, and reduced SCT-stimulated cAMP responses in cells expressing both receptors. This peptide was active in vivo by injection into mouse lateral ventricle, thereby suppressing water-drinking behavior after hyperosmotic shock, similar to SCTR knockouts. This supports the interpretation that active conformation of AT1aR is a key modulator of cAMP responses induced by SCT stimulation of SCTR. The SCTR/AT1aR complex is physiologically important, providing differential signaling to SCT in settings of hyperosmolality or food intake, modulated by differences in levels of ANGII.

  3. Implementing on-Campus Microteaching to Elicit Preservice Teachers' Reflection on Teaching Actions: Fresh Perspective on an Established Practice

    ERIC Educational Resources Information Center

    Amobi, Funmi A.; Irwin, Leslie

    2009-01-01

    This article calls for renewed emphasis on the use of on-campus microteaching to facilitate simultaneously preservice teachers' performance of effective teaching skills and their capability to reflect meaningfully on their emergent teaching actions. In making a case for greater focus on the implementation of microteaching in preservice teacher…

  4. The teacher's role in the establishment of whole-class dialogue in a fifth grade science classroom using argument-based inquiry

    NASA Astrophysics Data System (ADS)

    Benus, Matthew J.

    The purpose of this study was to examine the patterns of dialogue that were established and emerged in one experienced fifth-grade science teacher's classroom that used the argument-based inquiry (ABI) and the ways in which these patterns of dialogue and consensus-making were used toward the establishment of a grasp of science practice. Most current studies on ABI agree that it does not come naturally and is only acquired through practice. Additionally, the quality of dialogue is also understood to be an important link in support of student learning. Few studies have examined the ways in which a teacher develops whole-class dialogue over time and the ways in which patterns of dialogue shift over time. The research questions that guided this study were: (1) What were the initial whole-class dialogue patterns established by a fifth-grade science teacher who engaged in ABI? (2) How did the science teacher help to refine whole-class dialogue to support the agreeability of ideas constructed over time? This eighteen week study that took place in a small city of less than 15,000 in Midwestern United States was grounded in interactive constructivism, and utilized a qualitative design method to identify the ways in which an experienced fifth-grade science teacher developed whole-class dialogue and used consensus-making activities to develop the practice of ABI with his students. The teacher in this study used the Science Writing Heuristic (SWH) approach to ABI with twenty-one students who had no previous experience engaging in ABI. This teacher with 10 of years teaching experience was purposefully selected because he was proficient and experienced in practicing ABI. Multiple sources of data were collected, including classroom video with transcriptions, semi-structured interviews, after lesson conversations, and researcher's field notes. Data analysis used a basic qualitative approach. The results showed (1) that the teacher principally engaged in three forms of whole-class

  5. REAL-TIME INTRAVITAL IMAGING ESTABLISHES TUMOUR-ASSOCIATED MACROPHAGES AS THE EXTRASKELETAL TARGET OF BISPHOSPHONATE ACTION IN CANCER

    PubMed Central

    Junankar, Simon; Shay, Gemma; Jurczyluk, Julie; Ali, Naveid; Down, Jenny; Pocock, Nicholas; Parker, Andrew; Nguyen, Akira; Sun, Shuting; Kashemirov, Boris; McKenna, Charles E.; Croucher, Peter I.; Swarbrick, Alexander; Weilbaecher, Katherine; Phan, Tri Giang; Rogers, Michael J.

    2014-01-01

    Recent clinical trials have shown that bisphosphonate drugs improve breast cancer patient survival independent of their anti-resorptive effects on the skeleton. However, since bisphosphonates bind rapidly to bone mineral, the exact mechanisms of their anti-tumour action, particularly on cells outside of bone, remain unknown. Here we used real-time intravital two-photon microscopy to show extensive leakage of fluorescent bisphosphonate from the vasculature in 4T1 mouse mammary tumours, where it initially binds to areas of small, granular microcalcifications that are engulfed by tumour-associated macrophages (TAMs), but not tumour cells. Importantly, we also observed uptake of radiolabeled bisphosphonate in the primary breast tumour of a patient and showed the resected tumour to be infiltrated with TAMs and to contain similar granular microcalcifications. These data represent the first compelling in vivo evidence that bisphosphonates can target cells in tumours outside the skeleton and that their anti-tumour activity is likely to be mediated via TAMs. PMID:25312016

  6. Establishment of alternative potency test for botulinum toxin type A using compound muscle action potential (CMAP) in rats.

    PubMed

    Torii, Yasushi; Goto, Yoshitaka; Nakahira, Shinji; Ginnaga, Akihiro

    2014-11-01

    The biological activity of botulinum toxin type A has been evaluated using the mouse intraperitoneal (ip) LD50 test. This method requires a large number of mice to precisely determine toxin activity, and, as such, poses problems with regard to animal welfare. We previously developed a compound muscle action potential (CMAP) assay using rats as an alternative method to the mouse ip LD50 test. In this study, to evaluate this quantitative method of measuring toxin activity using CMAP, we assessed the parameters necessary for quantitative tests according to ICH Q2 (R1). This assay could be used to evaluate the activity of the toxin, even when inactive toxin was mixed with the sample. To reduce the number of animals needed, this assay was set to measure two samples per animal. Linearity was detected over a range of 0.1-12.8 U/mL, and the measurement range was set at 0.4-6.4 U/mL. The results for accuracy and precision showed low variability. The body weight was selected as a variable factor, but it showed no effect on the CMAP amplitude. In this study, potency tests using the rat CMAP assay of botulinum toxin type A demonstrated that it met the criteria for a quantitative analysis method.

  7. An Action Research Report on Applying Co-Operative Learning Techniques in an Intensive English Reading Class in China

    ERIC Educational Resources Information Center

    Fu, Xiao

    2013-01-01

    This study is to examine whether the implementation of CL in an intensive reading class has a positive effect on improving the passive situation of students, whether it helps activate their enthusiasm for and ease their anxiety of participation in language class activities, and whether it is helpful to their improvement of English proficiency. The…

  8. 10 CFR 1021.410 - Application of categorical exclusions (classes of actions that normally do not require EAs or EISs).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... has determined do not individually or cumulatively have a significant effect on the human environment... proposal is not “connected” (40 CFR 1508.25(a)(1)) to other actions with potentially significant impacts, is not related to other proposed actions with cumulatively significant impacts (40 CFR...

  9. The Confluence of Race, Gender, and Class among Community College Students: Assessing Attitudes toward Affirmative Action in College Admissions

    ERIC Educational Resources Information Center

    Zamani-Gallaher, Eboni M.

    2007-01-01

    This article examines the attitudes of baccalaureate aspiring community college students with regard to affirmative action in college admissions. Using data from UCLA's Cooperative Institutional Research Program (CIRP) Annual Freshman Year Survey, the study assessed determinants of approval or disapproval of affirmative action for 20,339 community…

  10. 10 CFR 1021.410 - Application of categorical exclusions (classes of actions that normally do not require EAs or EISs).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... proposal is not connected to other actions with potentially significant impacts (40 CFR 1508.25(a)(1)), is... CFR 1508.27(b)(7)), and is not precluded by 40 CFR 1506.1 or § 1021.211 of this part concerning... pursuant to FOIA. (See also 10 CFR 1021.340.) (f) Proposed recurring activities to be undertaken during...

  11. 10 CFR 1021.410 - Application of categorical exclusions (classes of actions that normally do not require EAs or EISs).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... proposal is not connected to other actions with potentially significant impacts (40 CFR 1508.25(a)(1)), is... CFR 1508.27(b)(7)), and is not precluded by 40 CFR 1506.1 or § 1021.211 of this part concerning... pursuant to FOIA. (See also 10 CFR 1021.340.) (f) Proposed recurring activities to be undertaken during...

  12. Class Action: Improving School Performance in the Developing World through Better Health and Nutrition. Directions in Development.

    ERIC Educational Resources Information Center

    Del Rosso, Joy Miller; Marek, Tonia

    This book summarizes how better nutrition and health for youths in developing nations will enhance: (1) school enrollment, attendance, and performance; (2) economic productivity; and (3) the health of future generations. By discussing the many low-cost and highly efficient actions that can improve school-age children's health and nutrition, this…

  13. Action Research for School Improvement: Studies on Able, Gifted and Talented Learners, Homework and White Working-Class Pupils

    ERIC Educational Resources Information Center

    Riggall, Anna, Ed.; Churches, Richard, Ed.; Elwick, Alex, Ed.

    2014-01-01

    This report is based on seven action research projects undertaken by teachers in CfBT academies in the school year 2012/13. The schools received research support that included training in research methods and undertook a smallscale research project within one of three thematic strands. Schools chose the themes for their research themselves and…

  14. 75 FR 41074 - Amendment of Class D and E Airspace; Everett, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-15

    ... Class E surface area airspace. This action enhances the safety and management of Instrument Flight Rules... established in advance by NOTAM. The Class E surface area airspace at Snohomish County Airport (Paine Field... Class E airspace Designated as Surface Areas. * * * * * ANM WA E2 Everett, WA Everett, Snohomish...

  15. Immunoglobulin class switching appears to be regulated by B cell antigen receptor-specific T cell action

    PubMed Central

    Lange, Hans; Hecht, Oliver; Zemlin, Michael; Trad, Ahmad; Tanasa, Radu I.; Schroeder, Harry W.; Lemke, Hilmar

    2013-01-01

    Summary Antigen affinity is commonly viewed as the driving force behind the selection for dominant clonotypes that can occur during the T cell-dependent processes of class switch recombination (CSR) and immune maturation. To test this view, we analyzed the variable gene repertoires of natural monoclonal antibodies to the hapten 2-phenyloxazolone (phOx) as well as those generated after phOx protein carrier-induced thymus-dependent or Ficoll-induced thymus independent antigen stimulation. In contrast to expectations, the extent of IgM heterogeneity proved similar and many IgM from these three populations exhibited similar or even greater affinities than the classic Ox1 clonotype that dominates only after CSR among primary and memory IgG. The population of clones that were selected during CSR exhibited a reduced VH/VL repertoire that was enriched for variable domains with shorter and more uniform CDR-H3 lengths and almost completely stripped of variable domains encoded by the large VH1 family. Thus, contrary to the current paradigm, T-cell dependent clonal selection during CSR appeared to select for VH family and CDR-H3 loop content even when the affinity provided by alternative clones exhibited similar to increased affinity for antigen. PMID:22531925

  16. Class analysis and the reorientation of class theory: the case of persisting differentials in educational attainment. 1996.

    PubMed

    Goldthorpe, John H

    2010-01-01

    In class analysis the main regularities that have been established by empirical research are not ones of long-term class formation or decomposition, as envisaged in Marxist or liberal theory, but rather ones that exhibit the powerful resistance to change of class relations and associated life-chances and patterns of social action. If these regularities are to be explained, theory needs to be correspondingly reoriented, and must abandon functionalist and teleological assumptions in favour of providing more secure micro-foundations. This argument is developed and illustrated in the course of an attempt to apply rational action theory to the explanation of persisting class differentials in educational attainment. PMID:20092500

  17. Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors

    SciTech Connect

    Sanches, Mario; Duffy, Nicole M.; Talukdar, Manisha; Thevakumaran, Nero; Chiovitti, David; Canny, Marella D.; Lee, Kenneth; Kurinov, Igor; Uehling, David; Al-awar, Rima; Poda, Gennadiy; Prakesch, Michael; Wilson, Brian; Tam, Victor; Schweitzer, Colleen; Toro, Andras; Lucas, Julie L.; Vuga, Danka; Lehmann, Lynn; Durocher, Daniel; Zeng, Qingping; Patterson, John B.; Sicheri, Frank

    2014-10-24

    Endoplasmic reticulum (ER) stress activates the unfolded protein response and its dysfunction is linked to multiple diseases. The stress transducer IRE1α is a transmembrane kinase endoribonuclease (RNase) that cleaves mRNA substrates to re-establish ER homeostasis. Aromatic ring systems containing hydroxy–aldehyde moieties, termed hydroxy–aryl–aldehydes (HAA), selectively inhibit IRE1α RNase and thus represent a novel chemical series for therapeutic development. We solved crystal structures of murine IRE1α in complex with three HAA inhibitors. HAA inhibitors engage a shallow pocket at the RNase-active site through pi-stacking interactions with His910 and Phe889, an essential Schiff base with Lys907 and a hydrogen bond with Tyr892. Structure–activity studies and mutational analysis of contact residues define the optimal chemical space of inhibitors and validate the inhibitor-binding site. These studies lay the foundation for understanding both the biochemical and cellular functions of IRE1α using small molecule inhibitors and suggest new avenues for inhibitor design.

  18. Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.

    PubMed

    Sanches, Mario; Duffy, Nicole M; Talukdar, Manisha; Thevakumaran, Nero; Chiovitti, David; Canny, Marella D; Lee, Kenneth; Kurinov, Igor; Uehling, David; Al-awar, Rima; Poda, Gennadiy; Prakesch, Michael; Wilson, Brian; Tam, Victor; Schweitzer, Colleen; Toro, Andras; Lucas, Julie L; Vuga, Danka; Lehmann, Lynn; Durocher, Daniel; Zeng, Qingping; Patterson, John B; Sicheri, Frank

    2014-08-28

    Endoplasmic reticulum (ER) stress activates the unfolded protein response and its dysfunction is linked to multiple diseases. The stress transducer IRE1α is a transmembrane kinase endoribonuclease (RNase) that cleaves mRNA substrates to re-establish ER homeostasis. Aromatic ring systems containing hydroxy-aldehyde moieties, termed hydroxy-aryl-aldehydes (HAA), selectively inhibit IRE1α RNase and thus represent a novel chemical series for therapeutic development. We solved crystal structures of murine IRE1α in complex with three HAA inhibitors. HAA inhibitors engage a shallow pocket at the RNase-active site through pi-stacking interactions with His910 and Phe889, an essential Schiff base with Lys907 and a hydrogen bond with Tyr892. Structure-activity studies and mutational analysis of contact residues define the optimal chemical space of inhibitors and validate the inhibitor-binding site. These studies lay the foundation for understanding both the biochemical and cellular functions of IRE1α using small molecule inhibitors and suggest new avenues for inhibitor design.

  19. The Phragmoplast-Orienting Kinesin-12 Class Proteins Translate the Positional Information of the Preprophase Band to Establish the Cortical Division Zone in Arabidopsis thaliana.

    PubMed

    Lipka, Elisabeth; Gadeyne, Astrid; Stöckle, Dorothee; Zimmermann, Steffi; De Jaeger, Geert; Ehrhardt, David W; Kirik, Viktor; Van Damme, Daniel; Müller, Sabine

    2014-06-27

    The preprophase band (PPB) is a faithful but transient predictor of the division plane in somatic cell divisions. Throughout mitosis the PPBs positional information is preserved by factors that continuously mark the division plane at the cell cortex, the cortical division zone, by their distinct spatio-temporal localization patterns. However, the mechanism maintaining these identity factors at the plasma membrane after PPB disassembly remains obscure. The pair of kinesin-12 class proteins PHRAGMOPLAST ORIENTING KINESIN1 (POK1) and POK2 are key players in division plane maintenance. Here, we show that POK1 is continuously present at the cell cortex, providing a spatial reference for the site formerly occupied by the PPB. Fluorescence recovery after photobleaching analysis combined with microtubule destabilization revealed dynamic microtubule-dependent recruitment of POK1 to the PPB during prophase, while POK1 retention at the cortical division zone in the absence of cortical microtubules appeared static. POK function is strictly required to maintain the division plane identity factor TANGLED (TAN) after PPB disassembly, although POK1 and TAN recruitment to the PPB occur independently during prophase. Together, our data suggest that POKs represent fundamental early anchoring components of the cortical division zone, translating and preserving the positional information of the PPB by maintaining downstream identity markers. PMID:24972597

  20. The Phragmoplast-Orienting Kinesin-12 Class Proteins Translate the Positional Information of the Preprophase Band to Establish the Cortical Division Zone in Arabidopsis thaliana[C][W

    PubMed Central

    Lipka, Elisabeth; Gadeyne, Astrid; Stöckle, Dorothee; Zimmermann, Steffi; De Jaeger, Geert; Ehrhardt, David W.; Kirik, Viktor; Van Damme, Daniel; Müller, Sabine

    2014-01-01

    The preprophase band (PPB) is a faithful but transient predictor of the division plane in somatic cell divisions. Throughout mitosis the PPBs positional information is preserved by factors that continuously mark the division plane at the cell cortex, the cortical division zone, by their distinct spatio-temporal localization patterns. However, the mechanism maintaining these identity factors at the plasma membrane after PPB disassembly remains obscure. The pair of kinesin-12 class proteins PHRAGMOPLAST ORIENTING KINESIN1 (POK1) and POK2 are key players in division plane maintenance. Here, we show that POK1 is continuously present at the cell cortex, providing a spatial reference for the site formerly occupied by the PPB. Fluorescence recovery after photobleaching analysis combined with microtubule destabilization revealed dynamic microtubule-dependent recruitment of POK1 to the PPB during prophase, while POK1 retention at the cortical division zone in the absence of cortical microtubules appeared static. POK function is strictly required to maintain the division plane identity factor TANGLED (TAN) after PPB disassembly, although POK1 and TAN recruitment to the PPB occur independently during prophase. Together, our data suggest that POKs represent fundamental early anchoring components of the cortical division zone, translating and preserving the positional information of the PPB by maintaining downstream identity markers. PMID:24972597

  1. Uptake of /sup 226/Ra by established vegetation and black cutworm larvae, Agrotis ipsilon (class Insecta: order Lepidoptera), on U mill tailings at Elliot Lake, Canada

    SciTech Connect

    Clulow, F.V.; Dave, N.K.; Lim, T.P.; Cloutier, N.R.

    1988-07-01

    Radium-226 levels in samples from an inactive U tailings site at Elliot Lake, Ontario, Canada, were: 9140 +/- 500 mBq g-1 dry weight in the substrate; 62 +/- 1 mBq g-1 dry weight in rye, Secale cereale, and less than 3.7 mBq g-1 dry weight in oats, Avena sativa, the dominant species established by revegetation of the tailings; and 117 +/- 7 mBq g-1 dry weight in washed and unwashed black cutworm larvae. Concentration ratios were: vegetation to tailings 0.001-0.007; black cutworms to vegetation 3.6 and black cutworms to tailings 0.01. The values are considered too low to be considered a hazard to herring gulls, Larus argentatus, which occasionally feed on cutworms.

  2. A method for establishing class III medical device equivalence: sodium hyaluronate (GenVisc 850) for the treatment of knee osteoarthritis

    PubMed Central

    Doros, Gheorghe; Lavin, Philip T; Daley, Michael; Miller, Larry E

    2016-01-01

    Although the concept of equivalence for drugs (generics) and biologics (biosimilars) has been readily adopted, the concept of equivalence or indistinguishable characteristics for class III medical devices has yet to be specifically addressed regarding a defined regulatory approval process in the US. In September 2015, GenVisc 850® (sodium hyaluronate), a hyaluronic acid approved for the treatment of knee osteoarthritis, was approved by the US Food and Drug Administration (FDA) based upon indistinguishable characteristics in comparison to an approved branded hyaluronic acid (Supartz®/Supartz FX™). The purpose of this paper is to review the methodology and report the main outcomes used to demonstrate clinical comparability of GenVisc 850 with Supartz/Supartz FX. The FDA approval was collectively attained using prospectively defined methods for preclinical, physical, and chemical testing, as well as noninferiority in clinical performance comparisons. Evidence from five randomized controlled studies of Supartz/Supartz FX vs saline control injections (used for Supartz approval), two randomized controlled trials of GenVisc 850 vs saline control injections, and one randomized controlled study of GenVisc 850 vs Supartz/Supartz FX provided evidence of safety for GenVisc 850. Efficacy was further assessed based on assessment of the same Supartz studies and three prospectively identified GenVisc 850 studies. A Bayesian network meta-analysis was used to demonstrate that the clinical efficacy of GenVisc 850 was noninferior to Supartz/Supartz FX and superior to saline control. Overall, safety of GenVisc 850 was similar to that of Supartz/Supartz FX and saline control injections, while efficacy of GenVisc 850 was noninferior to that of Supartz/Supartz FX and superior to saline control injections. PMID:27471412

  3. A method for establishing class III medical device equivalence: sodium hyaluronate (GenVisc 850) for the treatment of knee osteoarthritis.

    PubMed

    Doros, Gheorghe; Lavin, Philip T; Daley, Michael; Miller, Larry E

    2016-01-01

    Although the concept of equivalence for drugs (generics) and biologics (biosimilars) has been readily adopted, the concept of equivalence or indistinguishable characteristics for class III medical devices has yet to be specifically addressed regarding a defined regulatory approval process in the US. In September 2015, GenVisc 850® (sodium hyaluronate), a hyaluronic acid approved for the treatment of knee osteoarthritis, was approved by the US Food and Drug Administration (FDA) based upon indistinguishable characteristics in comparison to an approved branded hyaluronic acid (Supartz®/Supartz FX™). The purpose of this paper is to review the methodology and report the main outcomes used to demonstrate clinical comparability of GenVisc 850 with Supartz/Supartz FX. The FDA approval was collectively attained using prospectively defined methods for preclinical, physical, and chemical testing, as well as noninferiority in clinical performance comparisons. Evidence from five randomized controlled studies of Supartz/Supartz FX vs saline control injections (used for Supartz approval), two randomized controlled trials of GenVisc 850 vs saline control injections, and one randomized controlled study of GenVisc 850 vs Supartz/Supartz FX provided evidence of safety for GenVisc 850. Efficacy was further assessed based on assessment of the same Supartz studies and three prospectively identified GenVisc 850 studies. A Bayesian network meta-analysis was used to demonstrate that the clinical efficacy of GenVisc 850 was noninferior to Supartz/Supartz FX and superior to saline control. Overall, safety of GenVisc 850 was similar to that of Supartz/Supartz FX and saline control injections, while efficacy of GenVisc 850 was noninferior to that of Supartz/Supartz FX and superior to saline control injections. PMID:27471412

  4. Comparative efficacy of the Colgate Actibrush battery-powered toothbrush vs Oral-B CrossAction toothbrush on established plaque and gingivitis: a 6-week clinical study.

    PubMed

    Nathoo, S; Rustogi, K N; Petrone, M E; DeVizio, W; Zhang, Y P; Volpe, A R; Proskin, H M

    2000-01-01

    The objective of this clinical program was to compare the efficacy of the Colgate Actibrush battery-powered toothbrush and the Oral-B CrossAction Toothbrush (full head, soft bristle) for the control of supragingival plaque and gingivitis. Two independent clinical studies were conducted: Study 1 (repeated 3 times) was a single-use, examiner-blind clinical study designed to measure the removal of plaque after 24 hours of no oral hygiene. Study 2 was a definitive 6-week, examiner-blind clinical study designed to determine plaque and gingivitis efficacy at 3 and 6 weeks. Sixty-one men and women, who had refrained from using oral hygiene procedures for 24 hours, were entered into the study and stratified into 2 balanced groups according to baseline (prebrushing) plaque and gingivitis scores. For Study 1, Modified Navy Plaque Index (Rustogi Refinement) scores were obtained prebrushing and after a 1-minute supervised brushing with the assigned toothbrush and a commercially available toothpaste. On 3 separate occasions, after 24 hours of no oral hygiene, the Colgate Actibrush battery-powered toothbrush removed significantly more plaque than did the CrossAction Toothbrush. For Study 2, subjects were instructed to brush their teeth twice daily for 1 minute with the assigned toothbrush. Plaque Index scores and Löe-Silness Gingival Index scores were assessed after 3 and 6 weeks. At the 6-week examination, the group using the Colgate Actibrush battery-powered toothbrush exhibited a statistically significant reduction in both supragingival plaque and gingivitis, compared with the group that used the CrossAction Toothbrush. The results of these clinical studies support the conclusion that the Colgate Actibrush battery-powered toothbrush is clinically superior for the control of both supragingival plaque and gingivitis, as compared with the Oral-B CrossAction manual toothbrush.

  5. 31 CFR 30.4 - Q-4: What actions are necessary for a TARP recipient to comply with the standards established...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... or manipulation of earnings)? 30.4 Section 30.4 Money and Finance: Treasury Office of the Secretary... excessive risk or manipulation of earnings)? (a) General rule. To comply with the standards established... ensure that these plans do not encourage the manipulation of reported earnings of the TARP recipient...

  6. 31 CFR 30.4 - Q-4: What actions are necessary for a TARP recipient to comply with the standards established...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... or manipulation of earnings)? 30.4 Section 30.4 Money and Finance: Treasury Office of the Secretary... excessive risk or manipulation of earnings)? (a) General rule. To comply with the standards established... ensure that these plans do not encourage the manipulation of reported earnings of the TARP recipient...

  7. The Protestant Establishment Revisited

    ERIC Educational Resources Information Center

    Baltzell, E. Digby

    1976-01-01

    The author's book, "The Protestant Establishment: Aristocracy and Caste in America", is highly critical of the WASP (White-Anglo-Saxon-Protestant) establishment and proposed the development and need for some sort of upper-class ruling-group. Here is a re-evaluation of his book, now thirteen years old, by the author. (Author/RK)

  8. Technology assessment and citizen action

    NASA Technical Reports Server (NTRS)

    Mottur, E. R.

    1972-01-01

    The importance of citizen participation in the assessment process is discussed, and a system for citizen assessment action is proposed. A national assessment system is outlined. Citizen participation is considered essential in the assessment process, and impediments to effective action taken by citizens are discussed. These impediments are finance, organization and motivation, and information. The establishment of citizens' assessment associations is proposed, whose functioning would be fostered and regulated by the Citizens' Assessment Administration. The organization, functions, and financing of these associations are described. The implications of citizen action are indicated as the extensive use of class action suits, the broad interpretation of associated costs of litigation, and the use of present scientific research as evidence to assert that it is reasonable to conclude that certain consequences are probable to occur in the future.

  9. Complete elimination of established neuroblastoma by synergistic action of gamma-irradiation and DCs treated with rSeV expressing interferon-beta gene.

    PubMed

    Tatsuta, K; Tanaka, S; Tajiri, T; Shibata, S; Komaru, A; Ueda, Y; Inoue, M; Hasegawa, M; Suita, S; Sueishi, K; Taguchi, T; Yonemitsu, Y

    2009-02-01

    Dendritic cell (DC)-based immunotherapy has been investigated as a new therapeutic approach to intractable neuroblastomas; however, only limited clinical effect has been reported. To overcome the relatively low sensitivity of neuroblastomas against immunotherapy, we undertook a preclinical efficacy study to examine murine models to assess the combined effects of gamma-irradiation pretreatment and recombinant Sendai virus (ts-rSeV/dF)-mediated murine interferon-beta (mIFN-beta) gene transfer to DCs using established c1300 neuroblastomas. Similar to intractable neuroblastomas in the clinic, established c1300 tumors were highly resistant to monotherapy with either gamma-irradiation or DCs activated by ts-rSeV/dF without transgene (ts-rSeV/dF-null) that has been shown to be effective against other murine tumors, including B16F10 melanoma. In contrast, immunotherapy using DCs expressing mIFN-beta through ts-rSeV/dF (ts-rSeV/dF-mIFNbeta-DCs) effectively reduced tumor size, and its combination with gamma-irradiation pretreatment dramatically enhanced its antitumor effect, resulting frequently in the complete elimination of established c1300 tumors 7-9 mm in diameter, in a high survival rate among mice, and in the development of protective immunity in the mice against rechallenge by the tumor cells. These results indicate that the combination of ts-rSeV/dF-mIFNbeta-DCs with gamma-irradiation is a hopeful strategy for the treatment of intractable neuroblastomas, warranting further investigation in the clinical setting.

  10. Developing and establishing the validity and reliability of the perceptions toward Aviation Safety Action Program (ASAP) and Line Operations Safety Audit (LOSA) questionnaires

    NASA Astrophysics Data System (ADS)

    Steckel, Richard J.

    Aviation Safety Action Program (ASAP) and Line Operations Safety Audits (LOSA) are voluntary safety reporting programs developed by the Federal Aviation Administration (FAA) to assist air carriers in discovering and fixing threats, errors and undesired aircraft states during normal flights that could result in a serious or fatal accident. These programs depend on voluntary participation of and reporting by air carrier pilots to be successful. The purpose of the study was to develop and validate a measurement scale to measure U.S. air carrier pilots' perceived benefits and/or barriers to participating in ASAP and LOSA programs. Data from these surveys could be used to make changes to or correct pilot misperceptions of these programs to improve participation and the flow of data. ASAP and LOSA a priori models were developed based on previous research in aviation and healthcare. Sixty thousand ASAP and LOSA paper surveys were sent to 60,000 current U.S. air carrier pilots selected at random from an FAA database of pilot certificates. Two thousand usable ASAP and 1,970 usable LOSA surveys were returned and analyzed using Confirmatory Factor Analysis. Analysis of the data using confirmatory actor analysis and model generation resulted in a five factor ASAP model (Ease of use, Value, Improve, Trust and Risk) and a five factor LOSA model (Value, Improve, Program Trust, Risk and Management Trust). ASAP and LOSA data were not normally distributed, so bootstrapping was used. While both final models exhibited acceptable fit with approximate fit indices, the exact fit hypothesis and the Bollen-Stine p value indicated possible model mis-specification for both ASAP and LOSA models.

  11. An e-Class in Action: Experiences with ICT-Intensive Teaching and Learning of Discrete Dynamical Models at Secondary School

    ERIC Educational Resources Information Center

    Heck, Andre; Houwing, Harm; de Beurs, Cor

    2009-01-01

    In 2007, a small team of university and secondary school teachers jointly developed and piloted an e-class for 4th and 5th grade students (age: 16-17 yrs) at both pre-university and general vocational level. The goal was to develop and try out innovative ways of teaching mathematics that would enable schools to offer optional courses for small…

  12. Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases.

    PubMed

    Basarab, Gregory S; Kern, Gunther H; McNulty, John; Mueller, John P; Lawrence, Kenneth; Vishwanathan, Karthick; Alm, Richard A; Barvian, Kevin; Doig, Peter; Galullo, Vincent; Gardner, Humphrey; Gowravaram, Madhusudhan; Huband, Michael; Kimzey, Amy; Morningstar, Marshall; Kutschke, Amy; Lahiri, Sushmita D; Perros, Manos; Singh, Renu; Schuck, Virna J A; Tommasi, Ruben; Walkup, Grant; Newman, Joseph V

    2015-01-01

    With the diminishing effectiveness of current antibacterial therapies, it is critically important to discover agents that operate by a mechanism that circumvents existing resistance. ETX0914, the first of a new class of antibacterial agent targeted for the treatment of gonorrhea, operates by a novel mode-of-inhibition against bacterial type II topoisomerases. Incorporating an oxazolidinone on the scaffold mitigated toxicological issues often seen with topoisomerase inhibitors. Organisms resistant to other topoisomerase inhibitors were not cross-resistant with ETX0914 nor were spontaneous resistant mutants to ETX0914 cross-resistant with other topoisomerase inhibitor classes, including the widely used fluoroquinolone class. Preclinical evaluation of ETX0914 pharmacokinetics and pharmacodynamics showed distribution into vascular tissues and efficacy in a murine Staphylococcus aureus infection model that served as a surrogate for predicting efficacious exposures for the treatment of Neisseria gonorrhoeae infections. A wide safety margin to the efficacious exposure in toxicological evaluations supported progression to Phase 1. Dosing ETX0914 in human volunteers showed sufficient exposure and minimal adverse effects to expect a highly efficacious anti-gonorrhea therapy. PMID:26168713

  13. Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases

    PubMed Central

    Basarab, Gregory S.; Kern, Gunther H.; McNulty, John; Mueller, John P.; Lawrence, Kenneth; Vishwanathan, Karthick; Alm, Richard A.; Barvian, Kevin; Doig, Peter; Galullo, Vincent; Gardner, Humphrey; Gowravaram, Madhusudhan; Huband, Michael; Kimzey, Amy; Morningstar, Marshall; Kutschke, Amy; Lahiri, Sushmita D.; Perros, Manos; Singh, Renu; Schuck, Virna J. A.; Tommasi, Ruben; Walkup, Grant; Newman, Joseph V.

    2015-01-01

    With the diminishing effectiveness of current antibacterial therapies, it is critically important to discover agents that operate by a mechanism that circumvents existing resistance. ETX0914, the first of a new class of antibacterial agent targeted for the treatment of gonorrhea, operates by a novel mode-of-inhibition against bacterial type II topoisomerases. Incorporating an oxazolidinone on the scaffold mitigated toxicological issues often seen with topoisomerase inhibitors. Organisms resistant to other topoisomerase inhibitors were not cross-resistant with ETX0914 nor were spontaneous resistant mutants to ETX0914 cross-resistant with other topoisomerase inhibitor classes, including the widely used fluoroquinolone class. Preclinical evaluation of ETX0914 pharmacokinetics and pharmacodynamics showed distribution into vascular tissues and efficacy in a murine Staphylococcus aureus infection model that served as a surrogate for predicting efficacious exposures for the treatment of Neisseria gonorrhoeae infections. A wide safety margin to the efficacious exposure in toxicological evaluations supported progression to Phase 1. Dosing ETX0914 in human volunteers showed sufficient exposure and minimal adverse effects to expect a highly efficacious anti-gonorrhea therapy. PMID:26168713

  14. Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases.

    PubMed

    Basarab, Gregory S; Kern, Gunther H; McNulty, John; Mueller, John P; Lawrence, Kenneth; Vishwanathan, Karthick; Alm, Richard A; Barvian, Kevin; Doig, Peter; Galullo, Vincent; Gardner, Humphrey; Gowravaram, Madhusudhan; Huband, Michael; Kimzey, Amy; Morningstar, Marshall; Kutschke, Amy; Lahiri, Sushmita D; Perros, Manos; Singh, Renu; Schuck, Virna J A; Tommasi, Ruben; Walkup, Grant; Newman, Joseph V

    2015-07-14

    With the diminishing effectiveness of current antibacterial therapies, it is critically important to discover agents that operate by a mechanism that circumvents existing resistance. ETX0914, the first of a new class of antibacterial agent targeted for the treatment of gonorrhea, operates by a novel mode-of-inhibition against bacterial type II topoisomerases. Incorporating an oxazolidinone on the scaffold mitigated toxicological issues often seen with topoisomerase inhibitors. Organisms resistant to other topoisomerase inhibitors were not cross-resistant with ETX0914 nor were spontaneous resistant mutants to ETX0914 cross-resistant with other topoisomerase inhibitor classes, including the widely used fluoroquinolone class. Preclinical evaluation of ETX0914 pharmacokinetics and pharmacodynamics showed distribution into vascular tissues and efficacy in a murine Staphylococcus aureus infection model that served as a surrogate for predicting efficacious exposures for the treatment of Neisseria gonorrhoeae infections. A wide safety margin to the efficacious exposure in toxicological evaluations supported progression to Phase 1. Dosing ETX0914 in human volunteers showed sufficient exposure and minimal adverse effects to expect a highly efficacious anti-gonorrhea therapy.

  15. Action Recommendation for Cyber Resilience

    SciTech Connect

    Choudhury, Sutanay; Rodriguez, Luke R.; Curtis, Darren S.; Oler, Kiri J.; Nordquist, Peter L.; Chen, Pin-Yu; Ray, Indrajit

    2015-09-01

    This paper presents an unifying graph-based model for representing the infrastructure, behavior and missions of an enterprise. We describe how the model can be used to achieve resiliency against a wide class of failures and attacks. We introduce an algorithm for recommending resilience establishing actions based on dynamic updates to the models. Without loss of generality, we show the effectiveness of the algorithm for preserving latency based quality of service (QoS). Our models and the recommendation algorithms are implemented in a software framework that we seek to release as an open source framework for simulating resilient cyber systems.

  16. Effect of a supportive-educative program in the math class for stress, anxiety, and depression in female students in the third level of junior high school: An action research

    PubMed Central

    Emamjomeh, Seyedeh Mahtab; Bahrami, Masoud

    2015-01-01

    Background and Aim: Students in junior high school, particularly in the third level, are prone to a variety of stressors. This in turn might lead to stress, anxiety, depression, and other health-related problems. There are a very limited number of action research studies to identify the effect of stress management techniques among students. Therefore, a study was conducted to assess the effect of a program used in the math class to decrease the student's level of stress, anxiety, and depression. Material and Methods: This was an action research study, which was conducted in region three of the Education and Training Office of Isfahan, in the year 2012. Fifty-one students in a junior high school were selected and underwent a comprehensive stress management program. This program was prepared in collaboration with the students, their parents, teachers, and managers of the school, and was implemented approximately during a four-month period. The student's stress, anxiety, and depression were measured before and after the program using the DASS-21 questionnaire. Findings: The t-test identified that the mean scores of stress, anxiety, and depression after the intervention were significantly lower than the corresponding scores before the program. One-way analysis of variance (ANOVA) also showed that the students from the veterans (Janbaz) families had higher levels of stress compared to their classmates, who belonged to the non-veteran families (P< 0.05). Results: Education and implementation of stress management techniques including cognitive and behavioral interventions along with active and collaborative methods of learning in the math class might be useful both inside and outside the class, for better management of stress and other health-related problems of students. PMID:25767821

  17. "Racializing" Class

    ERIC Educational Resources Information Center

    Hatt-Echeverria, Beth; Urrieta, Luis, Jr.

    2003-01-01

    In an effort to explore how racial and class oppressions intersect, the authors use their autobiographical narratives to depict cultural and experiential continuity and discontinuity in growing up white working class versus Chicano working class. They specifically focus on "racializing class" due to the ways class is often used as a copout by…

  18. The Action Lawyers

    ERIC Educational Resources Information Center

    Lubenow, Gerald C.

    1972-01-01

    A description of the Serrano vs. Priest class action suit in California, challenging the system of financing education through property taxes; author touches upon the possibilities for the courts becoming change agents in the struggle for social reform. (SP)

  19. Establishing operations

    PubMed Central

    Michael, Jack

    1993-01-01

    The first two books on behavior analysis (Skinner, 1938; Keller & Schoenfeld, 1950) had chapter-length coverage of motivation. The next generation of texts also had chapters on the topic, but by the late 1960s it was no longer being given much treatment in the behavior-analytic literature. The present failure to deal with the topic leaves a gap in our understanding of operant functional relations. A partial solution is to reintroduce the concept of the establishing operation, defined as an environmental event, operation, or stimulus condition that affects an organism by momentarily altering (a) the reinforcing effectiveness of other events and (b) the frequency of occurrence of that part of the organism's repertoire relevant to those events as consequences. Discriminative and motivative variables can be distinguished as follows: The former are related to the differential availability of an effective form of reinforcement given a particular type of behavior; the latter are related to the differential reinforcing effectiveness of environmental events. An important distinction can also be made between unconditioned establishing operations (UEOs), such as food deprivation and painful stimulation, and conditioned establishing operations (CEOs) that depend on the learning history of the organism. One type of CEO is a stimulus that has simply been paired with a UEO and as a result may take on some of the motivative properties of that UEO. The warning stimulus in avoidance procedures is another important type of CEO referred to as reflexive because it establishes its own termination as a form of reinforcement and evokes the behavior that has accomplished such termination. Another CEO is closely related to the concept of conditional conditioned reinforcement and is referred to as a transitive CEO, because it establishes some other stimulus as a form of effective reinforcement and evokes the behavior that has produced that other stimulus. The multiple control of human

  20. Bacterial mutagenicity studies of DNA-intercalating aniline mustards: an insight into the mode of action of a novel class of anti-tumour drugs.

    PubMed

    Ferguson, L R; Gourdie, T A; Valu, K K; Denny, W A

    1989-10-01

    Bifunctional alkylating agents are reactive compounds which work by crosslinking DNA, but which have no special affinity for it. A series of acridine-linked aniline mustards of widely-varying alkylator reactivity (5-11), designed as DNA-directed alkylating agents, have been evaluated in various strains of Salmonella typhimurium with differing DNA repair capabilities to obtain information about their mechanism of action. The compounds showed greatly increased potency (determined as D37 values) compared with the corresponding untargeted mustards, in the repair-proficient strain TA1978+. All but the most unreactive mustards were considerably more potent (greater than 10-fold) in the corresponding repair-deficient strain TA98, indicating that DNA-crosslinking is the major cytotoxic mechanism. However, the mutagenic profile of the compounds in four Salmonella strains, particularly in the excision repair-deficient strains TA98 and TA100, suggest the compounds also form substantial levels of mutagenic monoadducts. The possibility that intercalative binding by the acridine chromophore provides an additional geometrical restraint on cross-linking by the mustard is an important facet of design which needs further study.

  1. 77 FR 17362 - Proposed Modification of Class D and Class E Airspace and Revocation of Class E Airspace...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-26

    ... an extension to a Class D or E surface area at Bellingham International Airport. This action... airspace and Class E airspace designated as surface area to meet current standards for IFR departures and... Class E airspace designated as an extension to a Class D or E surface area, and, therefore, would...

  2. Class Size.

    ERIC Educational Resources Information Center

    Ellis, Thomas I.

    1985-01-01

    After a brief introduction identifying current issues and trends in research on class size, this brochure reviews five recent studies bearing on the relationship of class size to educational effectiveness. Part 1 is a review of two interrelated and highly controversial "meta-analyses" or statistical integrations of research findings on class size,…

  3. Class Matters

    ERIC Educational Resources Information Center

    Valdata, Patricia

    2005-01-01

    Ever since George Washington opted for the title of president rather than king, Americans have been uncomfortable with the idea of class distinctions. This article presents an interview with Dr. Janet Galligani Casey regarding the idea of class distinctions. Galligani Casey, who grew up in a working-class neighborhood in Somerville, Massachusetts,…

  4. Action on Affirmative Action.

    ERIC Educational Resources Information Center

    Wells, Allen R.

    1987-01-01

    Describes how Lambton County (Ontario) school board implemented activities to encourage equal opportunity for employees and students: delegating temporary management responsibility equally to male/female staff, standardizing procedures for and publicizing promotional opportunities, assigning classroom tasks by pursuing class lists without regard…

  5. 77 FR 32895 - Modification of Class D and Class E Airspace and Revocation of Class E Airspace; Bellingham, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-04

    ... Regulations (14 CFR) Part 71 by modifying Class D airspace and Class E airspace designated as surface area to... or E surface area. This action is necessary for the safety and management of aircraft departing and.../Facility Directory. Paragraph 6002 Class E airspace designated as surface areas. * * * * * ANM WA...

  6. Molecular basis for class Ib anti-arrhythmic inhibition of cardiac sodium channels.

    PubMed

    Pless, Stephan A; Galpin, Jason D; Frankel, Adam; Ahern, Christopher A

    2011-06-14

    Cardiac sodium channels are established therapeutic targets for the management of inherited and acquired arrhythmias by class I anti-arrhythmic drugs (AADs). These drugs share a common target receptor bearing two highly conserved aromatic side chains, and are subdivided by the Vaughan-Williams classification system into classes Ia-c based on their distinct effects on the electrocardiogram. How can these drugs elicit distinct effects on the cardiac action potential by binding to a common receptor? Here we use fluorinated phenylalanine derivatives to test whether the electronegative surface potential of aromatic side chains contributes to inhibition by six class I AADs. Surprisingly, we find that class Ib AADs bind via a strong electrostatic cation-pi interaction, whereas class Ia and Ic AADs rely significantly less on this interaction. Our data shed new light on drug-target interactions underlying the inhibition of cardiac sodium channels by clinically relevant drugs and provide information for the directed design of AADs.

  7. Improving Teaching with Collaborative Action Research: An ASCD Action Tool

    ERIC Educational Resources Information Center

    Cunningham, Diane

    2011-01-01

    Once you've established a professional learning community (PLC), you need to get this ASCD (Association for Supervision and Curriculum Development) action tool to ensure that your PLC stays focused on addressing teaching methods and student learning problems. This ASCD action tool explains how your PLC can use collaborative action research to…

  8. Discriminating classes of developmental toxicants using gene expression profiling in the embryonic stem cell test.

    PubMed

    van Dartel, Dorien A M; Pennings, Jeroen L A; Robinson, Joshua F; Kleinjans, Jos C S; Piersma, Aldert H

    2011-03-01

    The embryonic stem cell test (EST) has been shown to be a promising in vitro method for the prediction of developmental toxicity. In our previous studies, we demonstrated that the implementation of gene expression analysis in the EST may further improve the identification of developmental toxicants. In the present study, we investigated if gene expression profiling could be used to discriminate compound classes with distinct modes of action (MoA) using the EST protocol. Gene expression data of our previous study were used and were analyzed of embryonic stem cell (ESC) differentiation cultures exposed to six compounds belonging to two classes with distinct MoA, namely phthalates and triazoles. We used three approaches to study class-characteristic gene regulation that may be useful for discrimination of compound classes. First, at the individual gene level, gene signatures characteristic for each class were identified that successfully discriminated both classes using principal component analysis. Second, at the functional level, enriched gene ontology (GO) biological processes showed their usefulness for class discrimination via hierarchical clustering. Third, two previously identified gene sets, which we designed to predict developmental toxicity, appeared successful in separating phthalate from triazole compounds. In summary, we established the possibility to discriminate between compound classes in the EST system using three different specific transcriptomics-based approaches. Differential gene expression information specific for the class of compound under study may be employed to optimize prioritization of compounds within that class for further testing.

  9. Choosing Actions

    PubMed Central

    Rosenbaum, David A.; Chapman, Kate M.; Coelho, Chase J.; Gong, Lanyun; Studenka, Breanna E.

    2013-01-01

    Actions that are chosen have properties that distinguish them from actions that are not. Of the nearly infinite possible actions that can achieve any given task, many of the unchosen actions are irrelevant, incorrect, or inappropriate. Others are relevant, correct, or appropriate but are disfavored for other reasons. Our research focuses on the question of what distinguishes actions that are chosen from actions that are possible but are not. We review studies that use simple preference methods to identify factors that contribute to action choices, especially for object-manipulation tasks. We can determine which factors are especially important through simple behavioral experiments. PMID:23761769

  10. Action semantics modulate action prediction.

    PubMed

    Springer, Anne; Prinz, Wolfgang

    2010-11-01

    Previous studies have demonstrated that action prediction involves an internal action simulation that runs time-locked to the real action. The present study replicates and extends these findings by indicating a real-time simulation process (Graf et al., 2007), which can be differentiated from a similarity-based evaluation of internal action representations. Moreover, results showed that action semantics modulate action prediction accuracy. The semantic effect was specified by the processing of action verbs and concrete nouns (Experiment 1) and, more specifically, by the dynamics described by action verbs (Experiment 2) and the speed described by the verbs (e.g., "to catch" vs. "to grasp" vs. "to stretch"; Experiment 3). These results propose a linkage between action simulation and action semantics as two yet unrelated domains, a view that coincides with a recent notion of a close link between motor processes and the understanding of action language.

  11. Neural Correlates of Human Action Observation in Hearing and Deaf Subjects

    PubMed Central

    Corina, David; Chiu, Yi-Shiuan; Knapp, Heather; Greenwald, Ralf; Jose-Robertson, Lucia San; Braun, Allen

    2007-01-01

    Accumulating evidence has suggested the existence of a human action recognition system involving inferior frontal, parietal, and superior temporal regions that may participate in both the perception and execution of actions. However, little is known about the specificity of this system in response to different forms of human action. Here we present data from PET neuroimaging studies from passive viewing of three distinct action types, intransitive self-oriented actions (e.g., stretching, rubbing one’s eyes, etc.), transitive object-oriented actions (e.g., opening a door, lifting a cup to the lips to drink), and the abstract, symbolic actions–signs used in American Sign Language. Our results show that these different classes of human actions engage a frontal/parietal/STS human action recognition system in a highly similar fashion. However, the results indicate that this neural consistency across motion classes is true primarily for hearing subjects. Data from deaf signers shows a non-uniform response to different classes of human actions. As expected, deaf signers engaged left-hemisphere perisylvian language areas during the perception of signed language signs. Surprisingly, these subjects did not engage the expected frontal/parietal/STS circuitry during passive viewing of non-linguistic actions, but rather reliably activated middle-occipital temporal-ventral regions which are known to participate in the detection of human bodies, faces, and movements. Comparisons with data from hearing subjects establish statistically significant contributions of middle-occipital temporal-ventral during the processing of non-linguistic actions in deaf signers. These results suggest that during human motion processing, deaf individuals may engage specialized neural systems that allow for rapid, online differentiation of meaningful linguistic actions from non-linguistic human movements. PMID:17459349

  12. Class Trash.

    ERIC Educational Resources Information Center

    Chemecology, 1992

    1992-01-01

    Presents a classroom activity in which students calculate the amount and types of trash thrown out by their class at school to investigate how much trash is generated, where it goes, and speculate about alternatives. Students need to be familiar with the concepts of weight, volume, and numbers. (MCO)

  13. Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship.

    PubMed

    Manda, Sudhakar; Sharma, Sadhana; Wani, Abubakar; Joshi, Prashant; Kumar, Vikas; Guru, Santosh K; Bharate, Sonali S; Bhushan, Shashi; Vishwakarma, Ram A; Kumar, Ajay; Bharate, Sandip B

    2016-01-01

    The screening of IIIM natural products repository for P-gp modulatory activity in P-gp over-expressing human adenocarcinoma LS-180 cells led to the identification of 7 natural products viz. withaferin, podophyllotoxin, 3-demethylcolchicine, agnuside, reserpine, seseberecine and fascaplysin as P-gp inducers. Fascaplysin (6a), a marine-derived bis-indole alkaloid, was the most potent among all of them, showing induction of P-gp with EC50 value of 25 nM. P-gp induction is one of the recently targeted strategy to increase amyloid-β clearance from Alzheimer brains. Thus, we pursued a medicinal chemistry of fascaplysin to establish its structure-activity relationship for P-gp induction activity. Four series of analogs viz. substituted quaternary fascaplysin analogs, D-ring opened quaternary analogs, D-ring opened non-quaternary analogs, and β-carbolinium analogs were synthesized and screened for P-gp induction activity. Among the total of 48 analogs screened, only quaternary nitrogen containing analogs 6a-g and 10a, 10h-l displayed promising P-gp induction activity; whereas non-planar non-quaternary analogs 9a-m, 13a-n, 15a-h were devoid of this activity. The P-gp induction activity of best compounds was then confirmed by western-blot analysis, which indicated that fascaplysin (6a) along with 4,5-difluoro analog of fascaplysin 6f and D-ring opened analog 10j displayed 4-8 fold increase in P-gp expression in LS-180 cells at 1 μM. Additionally, compounds 6a and 6f also showed inhibition of acetylcholinestease (AChE), an enzyme responsible for neuronal loss in Alzheimer's disease. Thus, fascaplysin and its analogs showing promising P-gp induction along with AChE inhibition at 1 μM, with good safety window (LS-180: IC50 > 10 μM, hGF: 4 μM), clearly indicates their promise for development as an anti-Alzheimer agent.

  14. 78 FR 51138 - Designation of Muncie (IN) To Provide Class X or Class Y Weighing Services

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-20

    ... Federal Register (78 FR 43854), GIPSA announced the designation of East Indiana to provide official... Class Y Weighing Services AGENCY: Grain Inspection, Packers and Stockyards Administration, USDA. ACTION...) to provide Class X or Class Y weighing services under the United States Grain Standards Act...

  15. 77 FR 52217 - Amendment of Class D and Class E Airspace; Bozeman, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-29

    ... Class D and Class E airspace at Bozeman Yellowstone International Airport, Bozeman, MT. This action... name to Bozeman Yellowstone International Airport. This improves the safety and management of... Rulemaking (NPRM) to modify Class D and E airspace at Bozeman, MT (77 FR 38227). Interested parties...

  16. 32 CFR 1633.6 - Consideration of classes.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the listing of the classes below. When grounds are established to place a registrant in one or more of the classes listed in the following table, the registrant shall be classified in the lowest class for... considered the lowest class, according to the following table: Class 1-A-O: Conscientious Objector...

  17. Action physics

    NASA Astrophysics Data System (ADS)

    McGinness, Lachlan P.; Savage, C. M.

    2016-09-01

    More than a decade ago, Edwin Taylor issued a "call to action" that presented the case for basing introductory university mechanics teaching around the principle of stationary action [E. F. Taylor, Am. J. Phys. 71, 423-425 (2003)]. We report on our response to that call in the form of an investigation of the teaching and learning of the stationary action formulation of physics in a first-year university course. Our action physics instruction proceeded from the many-paths approach to quantum physics to ray optics, classical mechanics, and relativity. Despite the challenges presented by action physics, students reported it to be accessible, interesting, motivational, and valuable.

  18. Class distinction

    NASA Astrophysics Data System (ADS)

    White, M. Catherine

    Typical 101 courses discourage many students from pursuing higher level science and math courses. Introductory classes in science and math serve largely as a filter, screening out all but the most promising students, and leaving the majority of college graduates—including most prospective teachers—with little understanding of how science works, according to a study conducted for the National Science Foundation. Because few teachers, particularly at the elementary level, experience any collegiate science teaching that stresses skills of inquiry and investigation, they simply never learn to use those methods in their teaching, the report states.

  19. 78 FR 72011 - Establishment of Class E Airspace; Umatilla, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ... Umatilla Municipal Airport, Umatilla, FL (78 FR 52425). After publication, the FAA found that the... Register of August 23, 2013, (78 FR 52425), FR Doc. 2013-20512, are corrected as follows: PART 71 0 1. On... the geographic coordinates in the airspace description of a final rule, published in the...

  20. 75 FR 39148 - Establishment of Class E Airspace; Lucin, UT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-08

    ..., UT (75 FR 14383). Interested parties were invited to participate in this rulemaking effort by... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR.... 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in...

  1. 75 FR 41076 - Establishment of Class E Airspace; Monterey, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-15

    ... follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E. O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp... at Monterey, CA (74 FR 59491). Interested parties were invited to participate in this rulemaking... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation...

  2. 76 FR 16530 - Establishment of Class E Airspace; Creighton, NE

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-24

    ... follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E. O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp... controlled airspace at Creighton Municipal Airport (76 FR 1380) Docket No. FAA-2010-1170. Interested parties... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation...

  3. 76 FR 39259 - Establishment of Class E Airspace; Brunswick, ME

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-06

    ... with the date July 25, 2011. Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565... Docket No. FAA-2011-0116, Airspace Docket No. 11- ANE-1, published on June 22, 2011 (76 FR 36285... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3)...

  4. 76 FR 80232 - Establishment of Class E Airspace; Oneonta, AL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-23

    ... Oneonta, AL (76 FR 58728) Docket No. FAA-2011-0744. Interested parties were invited to participate in this... ] ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does... read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR,...

  5. 78 FR 8962 - Establishment of Class E Airspace; Kasigluk, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-07

    ... airspace at Kasigluk, AK, to accommodate aircraft using Area Navigation (RNAV) Global Positioning System... FURTHER INFORMATION CONTACT: Richard Roberts, Federal Aviation Administration, Operations Support Group... INFORMATION: History On October 4, 2012, the FAA published in the Federal Register a notice of...

  6. 78 FR 32553 - Establishment of Class E Airspace; Boothbay, ME

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ..., Georgia 30320; telephone (404) 305-6364. SUPPLEMENTARY INFORMATION: History On March 28, 2013, the FAA... Boothbay, ME (78 FR 18929). Interested parties were invited to participate in this rulemaking effort by... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44...

  7. 78 FR 52085 - Establishment of Class E Airspace; Stockton, KS

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-22

    ..., TX 76137; telephone 817-321- 7716. SUPPLEMENTARY INFORMATION: History On April 30, 2013, the FAA... the Stockton, KS, area, creating controlled airspace at Rooks County Regional Airport (78 FR 25229... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44...

  8. 78 FR 41837 - Establishment of Class E Airspace; Parkston, SD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-12

    ..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation... the Parkston, SD, area, creating controlled airspace at Parkston Municipal Airport (78 FR 25232... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3)...

  9. 78 FR 33965 - Establishment of Class E Airspace; Linton, ND

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ... U.S.C. 106(g), 40103, 40113, 40120; E. O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71... the Linton, ND, area, creating controlled airspace at Linton Municipal Airport (78 FR 14478) Docket No... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44...

  10. 76 FR 43822 - Establishment of Class E Airspace; Hearne, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-22

    ... U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71... at Hearne Municipal Airport (76 FR 21831) Docket No. FAA-2011-0214. Interested parties were invited... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44...

  11. 77 FR 45240 - Establishment of Class E Airspace; Quakertown, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-31

    ... follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp... Quakertown, PA (77 FR 30438) Docket No. FAA-2012-0386. Interested parties were invited to participate in this... Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a Regulatory...

  12. 78 FR 33967 - Establishment of Class E Airspace; Captiva, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389... Captiva, FL (78 FR 14474). Interested parties were invited to participate in this rulemaking effort by... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44...

  13. 77 FR 45241 - Establishment of Class E Airspace; Apopka, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-31

    ..., 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by... Apopka, FL ] (77 FR 30439) Docket No. FAA-2012-0249. Interested parties were invited to participate in... rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does...

  14. 78 FR 41290 - Establishment of Class E Airspace; Sanibel, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-10

    ... Sanibel Island Heliport, Sanibel, FL. (78 FR 34557). After publication, the FAA found typographical errors... Sanibel Island Heliport, Sanibel, FL, as published in the Federal Register of June 10, 2013 (78 FR 34557), FR Doc. 2013-13107, is corrected to read: * * * * * ASO FL E5 Sanibel, FL Sanibel Island Heliport,...

  15. 78 FR 41839 - Establishment of Class E Airspace; Presidio, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-12

    ..., 40113, 40120; E. O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. ] Sec. 71.1 0 2. The... the Presidio, TX, area, creating controlled airspace at Presidio Lely International Airport (78 FR... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3)...

  16. 78 FR 48302 - Establishment of Class E Airspace; Wagner, SD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ..., area, creating controlled airspace at Wagner Municipal Airport (78 FR 31430) Docket No. FAA-2013-0004... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a... FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in 14 CFR...

  17. 76 FR 75449 - Establishment of Class E Airspace; Stuart, IA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-02

    ... follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp... controlled airspace at the City of Stuart Helistop (76 FR 53360) Docket No. FAA-2011-0831. Interested parties... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of...

  18. 78 FR 18802 - Establishment of Class E Airspace; Tecumseh, NE

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-28

    ..., area, creating additional controlled airspace at Tecumseh Municipal Airport (77 FR 71368) Docket No... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of... FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in 14 CFR...

  19. 78 FR 18801 - Establishment of Class E Airspace; Beeville, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-28

    ... follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E. O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp... Airport, Beeville, TX (77 FR 71365) Docket No. FAA- 2012-0821. Interested parties were invited to... 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR...

  20. 77 FR 1012 - Establishment of Class E Airspace; Inverness, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-09

    .... 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2..., FL (76 FR 66871) Docket No. FAA-2011-0540. Interested parties were invited to participate in this... Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a Regulatory...

  1. 76 FR 40598 - Establishment of Class E Airspace; Campbellton, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-11

    ...), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The... controlled airspace at 74 Ranch Airport (76 FR 20280) Docket No. FAA-2010-1053. Interested parties were... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44...

  2. 78 FR 41838 - Establishment of Class E Airspace; Colt, AR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-12

    ..., area, creating controlled airspace at Delta Regional Airport (78 FR 25231) Docket No. FAA-2012-1281... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of... FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in 14 CFR...

  3. 77 FR 16669 - Establishment of Class E Airspace; Bellefonte, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-22

    ...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389... surface at Bellefonte, PA (76 FR 79564). Interested parties were invited to participate in this rulemaking... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) ] does not warrant preparation of...

  4. 76 FR 43821 - Establishment of Class E Airspace; Ranger, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-22

    ... U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71... at Cook Canyon Ranch Airport (76 FR 26658) Docket No. FAA-2010-1240. Interested parties were invited... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44...

  5. 75 FR 41985 - Establishment of Class E Airspace; Syracuse, KS

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-20

    ... controlled airspace at Syracuse-Hamilton County Municipal Airport (75 FR 22045) Docket No. FAA-2010-0400... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of... continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E. O. 10854, 24 FR 9565,...

  6. 75 FR 37293 - Establishment of Class E Airspace; Hamilton, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-29

    ... additional controlled airspace at Hamilton Municipal Airport (75 FR 20794) Docket No. FAA-2009-0190... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a... read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E. O. 10854, 24 FR 9565, 3 CFR,...

  7. 76 FR 9220 - Establishment of Class E Airspace; Martinsville, IN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-17

    ..., creating additional controlled airspace at Morgan Hospital Heliport (75 FR 68557) Docket No. FAA-2010-1031...) is not a ``significant rule'' under DOT ] Regulatory Policies and Procedures (44 FR 11034; February...), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2....

  8. 75 FR 40719 - Establishment of Class E Airspace; Kemmerer, WY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-14

    ... E airspace at Kemmerer, WY to accommodate aircraft using a new Area Navigation (RNAV) Global Positioning System (GPS) Standard Instrument Approach Procedures (SIAPs) at Kemmerer Municipal Airport. This... Federal Register a notice of proposed rulemaking to amend controlled airspace at Kemmerer, WY (75 FR...

  9. 76 FR 64235 - Establishment of Class E Airspace; Nahunta, GA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ..., GA (76 FR 45478) Docket No. FAA-2011-0727. Subsequent to publication, the FAA found a typographical... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does... continues to read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565,...

  10. 78 FR 34557 - Establishment of Class E Airspace; Sanibel, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    ... Sanibel, FL (78 FR 14473). Interested parties were invited to participate in this rulemaking effort by... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p....

  11. 78 FR 76054 - Establishment of Class E Airspace; Chatom, AL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-16

    ... Chatom, AL (78 FR 54412) Docket No. FAA-2012-1186. Interested parties were invited to participate in this... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p....

  12. 76 FR 1999 - Establishment of Class E Airspace; Panguitch, UT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-12

    ... Panguitch, UT (75 FR 36585). The FAA agreed with a comment received to also expand controlled airspace from... feet above the surface at Panguitch, UT (75 FR 63730). Interested parties were invited to participate... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3)...

  13. 77 FR 19076 - Establishment of Class E Airspace; Marion, AL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-30

    ... Marion, AL (77 FR 771) Docket No. FAA-2011-0590. Interested parties were invited to participate in this... Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a Regulatory Evaluation.... 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0...

  14. 76 FR 52230 - Establishment of Class E Airspace; Forest, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-22

    ..., VA (76 FR 34196) Docket No. FAA-2011-0378. Interested parties were invited to participate in this... Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a Regulatory Evaluation.... 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0...

  15. 75 FR 57375 - Establishment of Class E Airspace; Toledo, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-21

    ... controlled airspace at Toledo, WA (75 FR 33559). Interested parties were invited to participate in this... Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a regulatory evaluation... continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E. O. 10854, 24 FR 9565,...

  16. 78 FR 59622 - Establishment of Class E Airspace; Akutan, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-27

    ..., Akutan, AK (78 FR 45477). Interested parties were invited to participate in this rulemaking effort by... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR...), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2....

  17. 76 FR 14801 - Establishment of Class E Airspace; Colebrook, NH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-18

    ..., NH (75 FR 81516). Interested parties were invited to participate in this rulemaking effort by... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a.... 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0...

  18. 78 FR 72008 - Establishment of Class E Airspace; Aliceville, AL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ... Aliceville, AL(78 FR 52111) Docket No. FAA-2013-0431. Interested parties were invited to participate in this... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a... continues to read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565,...

  19. 77 FR 75836 - Establishment of Class E Airspace; Walsenburg, CO

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ...) Global Positioning System (GPS) standard instrument approach ] procedures at the airport. This improves... geographic coordinates of the airport are updated at the request of National Aeronautical Navigation Services... Administration, Operations Support Group, Western Service Center, 1601 Lind Avenue SW., Renton, WA,...

  20. 78 FR 67297 - Establishment of Class E Airspace; Curtis, NE

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ...., area, creating additional controlled airspace at Curtis Municipal Airport (78 FR 48838) Docket No. FAA...) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The...

  1. 78 FR 58158 - Establishment of Class E Airspace; Wasatch, UT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-23

    ... Federal Register a notice of proposed rulemaking (NPRM) to amend controlled airspace at Wasatch, UT (78 FR... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a... read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR,...

  2. 78 FR 52425 - Establishment of Class E Airspace; Umatilla, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ... Umatilla, FL (78 FR 33265) Docket No. FAA-2013-0002. Interested parties were invited to participate in this... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does..., 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation...

  3. 78 FR 72010 - Establishment of Class E Airspace; Magee, MS

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ..., MS, (78 FR 48080) Docket No. FAA-2013-0430. Interested parties were invited to participate in this... Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a Regulatory Evaluation... follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963...

  4. 77 FR 29874 - Establishment of Class E Airspace; Freer, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ..., creating additional controlled airspace at Seven C's Ranch Airport (77 FR 4700) Docket No. FAA-2011-0904... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of... follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963...

  5. 75 FR 68416 - Establishment of Class E Airspace; Berryville, AR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-08

    ... U.S.C. 106(g), 40103, 40113, 40120; E. O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71..., creating controlled airspace at Carroll County Airport (75 FR 53876) Docket No. FAA-2010-0690. Interested... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44...

  6. 75 FR 51175 - Establishment of Class E Airspace; Perryville, MO

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-19

    ... read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959... additional controlled airspace at Perryville Municipal Airport (75 FR 23636) Docket No. FAA-2010-0403... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation...

  7. 78 FR 48300 - Establishment of Class E Airspace; Mahnomen, MN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ... the Mahnomen, MN, area, creating controlled airspace at Mahnomen County Airport (78 FR 25233) Docket...'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant... FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in 14 CFR...

  8. 75 FR 16330 - Establishment of Class E Airspace; Luverne, MN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... controlled airspace at Quentin Aanenson Field Airport (75 FR 3879) Docket No. FAA-2009-1150. Interested... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of... continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E. O. 10854, 24 FR 9565,...

  9. 75 FR 41984 - Establishment of Class E Airspace; Paynesville, MN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-20

    ... controlled airspace at Paynesville Municipal Airport (75 FR 22044) Docket No. FAA-2010-0399. Interested... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a... read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E. O. 10854, 24 FR 9565, 3 CFR,...

  10. 78 FR 48301 - Establishment of Class E Airspace; Walker, MN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ..., area, creating controlled airspace at Walker Municipal Airport (78 FR 25234) Docket No. FAA-2013-0266... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a... FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in 14 CFR...

  11. 75 FR 57847 - Establishment of Class E Airspace; Homestead, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-23

    ..., FL (75 FR 26148) Docket No. FAA-2010-0429. Interested parties were invited to participate in this... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR..., 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in 14...

  12. 75 FR 8484 - Establishment of Class E Airspace; Langdon, ND

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-25

    ..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation... controlled airspace at Robertson Field Airport (74 FR 63684) Docket No. FAA-2009-0535. Interested parties... 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR...

  13. 75 FR 29657 - Establishment of Class E Airspace; Marianna, AR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-27

    ... controlled airspace at Marianna/Lee County Airport--Steve Edwards Field (75 FR 12161) Docket No. FAA-2009...'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant... FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in 14 CFR...

  14. 76 FR 73505 - Establishment of Class E Airspace; Nashville, AR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-29

    ... additional controlled airspace at Howard County Airport (76 FR 53359) Docket No. FAA-2011-0497. Interested...'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant... follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963...

  15. Technical Basis for Also Using Health-Risk Assessment to Establish Contaminant Boundaries for Corrective Action Units (CAUs) of the Underground Test Area (UGTA) at the Nevada Test Site (NTS)

    SciTech Connect

    Daniels, J I; Tompson, A F

    2003-12-29

    This technical basis document serves two purposes. First, it provides a detailed discussion of the rationale and procedures suitable for deriving a risk-based contaminant boundary that will protect public health unambiguously, along with examples that are intended as illustrative only to facilitate understanding. Second, it explains the benefits of using such information as the framework for fostering risk communication to educate, inform, and enlighten, and importantly, to fully disclose the goals and structure of contaminant boundaries. To determine a contaminant boundary within a CAU, standards or criteria must be adopted that establish whether groundwater is safe or unsafe for public (and worker) use. For purposes of this discussion, drinking water consumption is considered the pathway of exposure. However, in practice, a realistic land-use scenario must be described and agreed upon before a prospective, realistic risk-based calculation is performed. Otherwise, it will not be clear whether consumption of drinking water is a even appropriate. For example, the future land use that is defined may not even permit access to the contaminated water (e.g., denial of use by law and stewardship; or a lack of accessibility), and in that situation there would be no exposure and no potential health consequences. Taking into consideration that consumption of the groundwater is feasible, the groundwater is deemed unsafe if it contains radionuclide contamination that exceeds the criteria that the United States Environmental Protection Agency (EPA) considers in establishing regulatory standards for drinking water contaminants, including radionuclides generally (i.e., a target range for lifetime excess-cancer risk that is not to exceed 10{sup -4} [1/10,000] and ideally is less than 10{sup -6} [1/1,000,000]) (see EPA, 2000a). Thus, the maximum contaminant levels (MCLs) for substances in drinking water are considered to be health-protective and generally are derived on the basis

  16. Affirmative Action Plan.

    ERIC Educational Resources Information Center

    Triton Coll., River Grove, IL.

    In order to develop an affirmative action plan at Triton College, the college President appointed a committee made up of nine representatives from the various college constituencies, the majority of which were women and minorities, to determine the objectives to be achieved and how to implement them, and to establish appropriate review procedures.…

  17. Literacy Education Action.

    ERIC Educational Resources Information Center

    Clymer, Carol

    The Literacy Education Action (LEA) program was established in the fall of 1985 under the initiative of the president of the El Paso Community College (Texas). During 1985 and 1986, LEA concentrated on developing its own literacy tutoring program, including recruiting and training volunteers and community members with reading skills below the…

  18. Demonstrations to Wake Up Large Classes.

    ERIC Educational Resources Information Center

    Howes, Ruth; Watson, James

    1982-01-01

    A general strategy and specific examples for demonstrations in large physics classes are given. Such "action" demonstrations may involve students moving around the class to demonstrate molecular behavior in different states of matter, and effect of heat in changing state. (JN)

  19. To amend a provision of the Securities Act of 1933 directing the Securities and Exchange Commission to add a particular class of securities to those exempted under such Act to provide a deadline for such action.

    THOMAS, 113th Congress

    Rep. McHenry, Patrick T. [R-NC-10

    2013-02-14

    05/16/2013 Received in the Senate and Read twice and referred to the Committee on Banking, Housing, and Urban Affairs. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  20. Action Learning.

    ERIC Educational Resources Information Center

    1996

    These four papers were presented at a symposium on action learning moderated by Lex Dilworth at the 1996 conference of the Academy of Human Resource Development. "Developing an Infrastructure for Individual and Organizational Change: Transfer of Learning from an Action Reflection Learning (ARL) Program" (ARL Inquiry) reports findings from a study…

  1. The formation of linked perceptual classes.

    PubMed Central

    Fields, Lanny; Matneja, Priya; Varelas, Antonios; Belanich, James; Fitzer, Adrienne; Shamoun, Kim

    2002-01-01

    Multiple-exemplar training with stimuli in four domains induced two new fill-based (A1' and A2') and satellite-image-based (B1' and B2') perceptual classes. Conditional discriminations were established between the endpoints of the A1' and B1' classes as well as the A2' and B2' classes. The emergence of linked perceptual classes was evaluated by the performances occasioned by nine cross-class probes that contained fill variants as samples and satellite variants as comparisons, along with nine other cross-class probes that consisted of satellite variants as samples and fill variants as comparisons. The 18 probes were first presented serially and then concurrently. Class-consistent responding indicated the emergence of linked perceptual classes. Of the linked perceptual classes, 70% emerged during the initial serial test. An additional 20% of the linked perceptual classes emerged during the subsequently presented concurrent test block. Thus, linked perceptual classes emerged on an immediate or delayed basis. Linked perceptual classes, then, share structural and fuctional similarities with equivalence classes, generalized equivalence classes, cross-modal classes, and complex maturally occurring categories, and may clarify processes such as intersensory perception. PMID:12507004

  2. The formation of linked perceptual classes.

    PubMed

    Fields, Lanny; Matneja, Priya; Varelas, Antonios; Belanich, James; Fitzer, Adrienne; Shamoun, Kim

    2002-11-01

    Multiple-exemplar training with stimuli in four domains induced two new fill-based (A1' and A2') and satellite-image-based (B1' and B2') perceptual classes. Conditional discriminations were established between the endpoints of the A1' and B1' classes as well as the A2' and B2' classes. The emergence of linked perceptual classes was evaluated by the performances occasioned by nine cross-class probes that contained fill variants as samples and satellite variants as comparisons, along with nine other cross-class probes that consisted of satellite variants as samples and fill variants as comparisons. The 18 probes were first presented serially and then concurrently. Class-consistent responding indicated the emergence of linked perceptual classes. Of the linked perceptual classes, 70% emerged during the initial serial test. An additional 20% of the linked perceptual classes emerged during the subsequently presented concurrent test block. Thus, linked perceptual classes emerged on an immediate or delayed basis. Linked perceptual classes, then, share structural and fuctional similarities with equivalence classes, generalized equivalence classes, cross-modal classes, and complex maturally occurring categories, and may clarify processes such as intersensory perception.

  3. Technology assessment and citizen action

    NASA Technical Reports Server (NTRS)

    Mottur, E. R.

    1975-01-01

    Citizen participation in the nation's total social, political, economic decisionmaking processes was studied. Impediments are discussed which prevent citizens from taking effective assessment action; these include finance, organization and motivation, and information. The proposal for establishing citizens assessment associations is considered along with implications of citizen assessment action.

  4. Class I antiarrhythmic drugs inhibit human cardiac two-pore-domain K(+) (K2 ₂p) channels.

    PubMed

    Schmidt, Constanze; Wiedmann, Felix; Schweizer, Patrick A; Becker, Rüdiger; Katus, Hugo A; Thomas, Dierk

    2013-12-01

    Class IC antiarrhythmic drugs are commonly used for rhythm control in atrial fibrillation. In addition, class I drugs are administered to suppress ventricular tachyarrhythmia in selected cases. The multichannel blocking profile of class I compounds includes reduction of cardiac potassium currents in addition to their primary mechanism of action, sodium channel inhibition. Blockade of two-pore-domain potassium (K2P) channels in the heart causes action potential prolongation and may provide antiarrhythmic action in atrial fibrillation. This study was designed to elucidate inhibitory effects of class I antiarrhythmic drugs on K2P channels. Human K2P2.1 (TREK1) and hK2P3.1 (TASK1) channels were systematically tested for their sensitivity to clinically relevant class IA (ajmaline), class IB (mexiletine), and class IC (propafenone) antiarrhythmic compounds using whole-cell patch clamp and two-electrode voltage clamp electrophysiology in Chinese hamster ovary cells and in Xenopus oocytes. Mexiletine and propafenone inhibited hK2P2.1 (IC50,mexiletine=173µM; IC50,propafenone=7.6µM) and hK2P3.1 channels (IC50,mexiletine=97.3µM; IC50,propafenone=5.1µM) in mammalian cells. Ajmaline did not significantly reduce current amplitudes. K2P channels were blocked in open and closed states, resulting in resting membrane potential depolarization. Open rectification properties of the channels were not affected by class I drugs. In summary, class I antiarrhythmic drugs target cardiac K2P K(+) channels. Blockade of hK2P2.1 and hK2P3.1 potassium currents provides mechanistic evidence to establish cardiac K2P channels as antiarrhythmic drug targets. PMID:24070813

  5. 77 FR 15575 - Modification of Class E Airspace; Sheridan, WY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-16

    ... Federal Aviation Administration 14 CFR Part 71 Modification of Class E Airspace; Sheridan, WY AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E... controlled airspace at Sheridan, WY (76 FR 79563). Interested parties were invited to participate in...

  6. The class certification of medical monitoring claims.

    PubMed

    Venugopal, Pankaj

    2002-10-01

    The tort claim of medical monitoring has produced a disarrayed set of state and federal court opinions. The procedural dimensions of this claim are as vexing as the related substantive issues with which courts and commentators have long been grappling. Ordinarily, mass tort actions, typically involving claims for money damages, are certified under Rule 23(b)(3), which class category requires the right to notice and to opt out of a proceeding, and the fulfillment of "predominance" and "superiority" requirements. Such features are absent in Rule 23's mandatory classes. Nevertheless, this Note argues that it is appropriate for claims exclusively for medical monitoring to be certified as a mandatory class action under Rule 23(b)(2) of the Federal Rules of Civil Procedure or its state law counterparts. Given that a medical monitoring fund is an equitable remedy, nonpreclusive of a future damages claim, and groupwide in nature, the (b)(2) class category adequately protects the due process rights of class plaintiffs.

  7. Establishing operations and reinforcement effects.

    PubMed

    Vollmer, T R; Iwata, B A

    1991-01-01

    Positive reinforcement procedures have had a major impact on educational programs for the developmentally disabled; nevertheless, variation in reinforcer effectiveness both within and across individuals is a common phenomenon. This study examined one class of variables--establishing operations--that might influence the effectiveness of reinforcers. Five developmentally disabled adult males participated. Responding on one of two motor tasks--switch closure or block placement--was assessed during baseline, satiation, and deprivation conditions with respect to three classes of consequences: small food items, music, and social praise. Deprivation and satiation conditions were constructed so as not to alter significantly the normal course of events in a subject's day. For example, food deprivation entailed scheduling sessions just prior to a subject's regular lunch, and social deprivation involved limiting a subject's access to social interaction for 15 minutes, during which time the subject had access to an assortment of other activities. Results showed that each stimulus class functioned as reinforcement with different degrees of effectiveness during satiation versus deprivation conditions. These results are discussed in light of previous research on enhancement of reinforcer efficacy as well as the assessment and identification of functional reinforcers, and implications are presented for future research and client habilitation. PMID:1890048

  8. Action perception predicts action performance

    PubMed Central

    Bailey, Heather R.; Kurby, Christopher A.; Giovannetti, Tania; Zacks, Jeffrey M.

    2013-01-01

    Everyday action impairments often are observed in demented older adults, and they are common potential barriers to functional independence. We evaluated whether the ability to segment and efficiently encode activities is related to the ability to execute activities. Further, we evaluated whether brain regions important for segmentation also were important for action performance. Cognitively healthy older adults and those with very mild or mild dementia of the Alzheimer's type watched and segmented movies of everyday activities and then completed the Naturalistic Action Test. Structural MRI was used to measure volume in the dorsolateral prefrontal cortex (DLPFC), medial temporal lobes (MTL), posterior cortex, and anterior cingulate cortex (ACC). Dementia status and the ability to segment everyday activities strongly predicted naturalistic action performance, and MTL volume largely accounted for this relationship. In addition, the current results supported the Omission-Commission Model: Different cognitive and neurological mechanisms predicted different types of action error. Segmentation, dementia severity, and MTL volume predicted everyday omission errors, DLPFC volume predicted commission errors, and ACC volume predicted action additions. These findings suggest that event segmentation may be critical for effective action production, and that the segmentation and production of activities may recruit the same event representation system. PMID:23851113

  9. Action perception predicts action performance.

    PubMed

    Bailey, Heather R; Kurby, Christopher A; Giovannetti, Tania; Zacks, Jeffrey M

    2013-09-01

    Everyday action impairments often are observed in demented older adults, and they are common potential barriers to functional independence. We evaluated whether the ability to segment and efficiently encode activities is related to the ability to execute activities. Further, we evaluated whether brain regions important for segmentation also were important for action performance. Cognitively healthy older adults and those with very mild or mild dementia of the Alzheimer's type watched and segmented movies of everyday activities and then completed the Naturalistic Action Test. Structural MRI was used to measure volume in the dorsolateral prefrontal cortex (DLPFC), medial temporal lobes (MTL), posterior cortex, and anterior cingulate cortex (ACC). Dementia status and the ability to segment everyday activities strongly predicted naturalistic action performance, and MTL volume largely accounted for this relationship. In addition, the current results supported the Omission-Commission Model: Different cognitive and neurological mechanisms predicted different types of action error. Segmentation, dementia severity, and MTL volume predicted everyday omission errors, DLPFC volume predicted commission errors, and ACC volume predicted action additions. These findings suggest that event segmentation may be critical for effective action production, and that the segmentation and production of activities may recruit the same event representation system.

  10. Predicting modes of toxic action from chemical structure: an overview.

    PubMed

    Bradbury, S P

    1994-01-01

    In the field of environmental toxicology, and especially aquatic toxicology, quantitative structure activity relationships (QSARs) have developed as scientifically-credible tools for predicting the toxicity of chemicals when little or no empirical data are available. A basic and fundamental understanding of toxicological principles has been considered crucial to the continued acceptance and application of these techniques as biologically relevant. As a consequence, there has been an evolution of QSAR development and application from that of a chemical-class perspective to one that is more consistent with assumptions regarding modes of toxic action. The assessment of a compound's likely mode of toxic action is critical for a correct QSAR selection; incorrect mode of action-based QSAR selections can result in 10- to 1000-fold errors in toxicity predictions. The establishment of toxicologically-credible techniques to assess mode of toxic action from chemical structure requires toxicodynamic knowledge bases that are clearly defined with regard to exposure regimes and biological models/endpoints and based on compounds that adequately span the diversity of chemicals anticipated for future applications. With such knowledge bases classification systems, including rule-based experts systems, have been established for use in predictive aquatic toxicology applications. PMID:8790641

  11. IRAC: Mode of action classification and insecticide resistance management.

    PubMed

    Sparks, Thomas C; Nauen, Ralf

    2015-06-01

    Insecticide resistance is a long standing and expanding problem for pest arthropod control. Effective insecticide resistance management (IRM) is essential if the utility of current and future insecticides is to be preserved. Established in 1984, the Insecticide Resistance Action Committee (IRAC) is an international association of crop protection companies. IRAC serves as the Specialist Technical Group within CropLife International focused on ensuring the long term efficacy of insect, mite and tick control products through effective resistance management for sustainable agriculture and improved public health. A key function of IRAC is the continued development of the Mode of Action (MoA) classification scheme, which provides up-to-date information on the modes of action of new and established insecticides and acaricides and which serves as the basis for developing appropriate IRM strategies for crop protection and vector control. The IRAC MoA classification scheme covers more than 25 different modes of action and at least 55 different chemical classes. Diversity is the spice of resistance management by chemical means and thus it provides an approach to IRM providing a straightforward means to identify potential rotation/alternation options.

  12. 29 CFR 1608.4 - Establishing affirmative action plans.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... employment practices do, or tend to, exclude, disadvantage, restrict, or result in adverse impact or... amended, and its implementing regulations, including 41 CFR part 60-2 (known as Revised Order 4), or... other person subject to title VII should be concerned with the effect on its employment practices...

  13. 29 CFR 1608.4 - Establishing affirmative action plans.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... career advancement training, both classroom and on-the-job, to employees locked into dead end jobs; and... amended, and its implementing regulations, including 41 CFR part 60-2 (known as Revised Order 4), or... range, interim goals and timetables for the specific job classifications, all of which should take...

  14. 29 CFR 1608.4 - Establishing affirmative action plans.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... career advancement training, both classroom and on-the-job, to employees locked into dead end jobs; and... amended, and its implementing regulations, including 41 CFR part 60-2 (known as Revised Order 4), or... range, interim goals and timetables for the specific job classifications, all of which should take...

  15. 29 CFR 1608.4 - Establishing affirmative action plans.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... career advancement training, both classroom and on-the-job, to employees locked into dead end jobs; and... amended, and its implementing regulations, including 41 CFR part 60-2 (known as Revised Order 4), or... range, interim goals and timetables for the specific job classifications, all of which should take...

  16. Unraveling the Complexity of Critical Consciousness, Political Efficacy, and Political Action Among Marginalized Adolescents.

    PubMed

    Diemer, Matthew A; Rapa, Luke J

    2016-01-01

    This research examines the complex patterns by which distinct dimensions of critical consciousness may lead marginalized adolescents toward distinct forms of political action. Structural equation modeling was applied to nationally representative data from the Civic Education Study (2,811 ninth graders; Mage  = 14.6), first establishing the measurement invariance of constructs across samples of poor or working class African American and Latino/a adolescents. Perceptions of societal inequality and aspirational beliefs that society ought to be more equal differentially predicted expected voting, conventional political action, and social action-while controlling for civic achievement and with nuances between ethnic and racial groups. Contrary to hypotheses and extant scholarship, political efficacy did not mediate or moderate relations between critical reflection and disparate forms of political action.

  17. 77 FR 38227 - Proposed Amendment of Class D and Class E Airspace; Bozeman, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-27

    ... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The incorporation by...). SUMMARY: This action proposes to modify Class D and Class E airspace at Bozeman Yellowstone...

  18. 77 FR 7525 - Revision of Class D and Class E Airspace; Hawthorne, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-13

    ... Class D and Class E airspace at Jack Northrop Field/Hawthorne Municipal Airport, Hawthorne, CA... location. This action is a result of the FAA's biennial review, along with a study of the Jack Northrop... CONTACT: Richard Roberts, Federal Aviation Administration, Operations Support Group, Western...

  19. Conversations to Transform Geometry Class

    ERIC Educational Resources Information Center

    Szydlik, Jennifer Earles; Parrott, Amy; Belnap, Jason Knight

    2016-01-01

    Classroom culture is negotiated and established through both conversations and practices. Traditionally, teachers and researchers have focused primarily on the individual and social construction of mathematical content--that is, students' conceptual understanding and procedural skills--through mathematical actions and practices. This article…

  20. 77 FR 56174 - Proposed Establishment of Class D and Class E Airspace; Camp Guernsey, WY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-12

    ... holidays. An informal docket may also be examined during normal business hours at the Northwest Mountain Regional Office of the Federal Aviation Administration, Air Traffic Organization, Western Service Center...; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034;...

  1. 78 FR 57545 - Proposed Establishment of Class D Airspace and Class E Airspace; Laguna AAF, AZ

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-19

    ...'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant...), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The... the airport. Issued in Seattle, Washington, on August 29, 2013. Christopher Ramirez, Acting...

  2. 75 FR 8285 - Establishment of Class D Airspace, Modification of Class E Airspace; Columbus, GA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ...; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February..., 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The incorporation by... 700 feet above the surface would be modified for the safety and management of IFR operations....

  3. 76 FR 70051 - Establishment of Class D and Amendment of Class E Airspace; Los Angeles, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-10

    ... Federal Register a notice of proposed rulemaking to amend controlled airspace at Los Angeles, CA (76 FR...) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26...), 40103, 40113, 40120; E. O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2....

  4. Treatment of Established Status Epilepticus.

    PubMed

    Falco-Walter, Jessica J; Bleck, Thomas

    2016-01-01

    Status epilepticus is the most severe form of epilepsy, with a high mortality rate and high health care costs. Status epilepticus is divided into four stages: early, established, refractory, and super-refractory. While initial treatment with benzodiazepines has become standard of care for early status epilepticus, treatment after benzodiazepine failure (established status epilepticus (ESE)) is incompletely studied. Effective treatment of ESE is critical as morbidity and mortality increases dramatically the longer convulsive status epilepticus persists. Phenytoin/fosphenytoin, valproic acid, levetiracetam, phenobarbital, and lacosamide are the most frequently prescribed antiseizure medications for treatment of ESE. To date there are no class 1 data to support pharmacologic recommendations of one agent over another. We review each of these medications, their pharmacology, the scientific evidence in support and against each in the available literature, adverse effects and safety profiles, dosing recommendations, and limitations of the available evidence. We also discuss future directions including the established status epilepticus treatment trial (ESETT). Substantial further research is urgently needed to identify these patients (particularly those with non-convulsive status epilepticus), elucidate the most efficacious antiseizure treatment with head-to-head randomized prospective trials, and determine whether this differs for convulsive vs. non-convulsive ESE. PMID:27120626

  5. Treatment of Established Status Epilepticus

    PubMed Central

    Falco-Walter, Jessica J.; Bleck, Thomas

    2016-01-01

    Status epilepticus is the most severe form of epilepsy, with a high mortality rate and high health care costs. Status epilepticus is divided into four stages: early, established, refractory, and super-refractory. While initial treatment with benzodiazepines has become standard of care for early status epilepticus, treatment after benzodiazepine failure (established status epilepticus (ESE)) is incompletely studied. Effective treatment of ESE is critical as morbidity and mortality increases dramatically the longer convulsive status epilepticus persists. Phenytoin/fosphenytoin, valproic acid, levetiracetam, phenobarbital, and lacosamide are the most frequently prescribed antiseizure medications for treatment of ESE. To date there are no class 1 data to support pharmacologic recommendations of one agent over another. We review each of these medications, their pharmacology, the scientific evidence in support and against each in the available literature, adverse effects and safety profiles, dosing recommendations, and limitations of the available evidence. We also discuss future directions including the established status epilepticus treatment trial (ESETT). Substantial further research is urgently needed to identify these patients (particularly those with non-convulsive status epilepticus), elucidate the most efficacious antiseizure treatment with head-to-head randomized prospective trials, and determine whether this differs for convulsive vs. non-convulsive ESE. PMID:27120626

  6. Action Research

    ERIC Educational Resources Information Center

    Milton-Brkich, Katie Lynn; Shumbera, Kristen; Beran, Becky

    2010-01-01

    Defined as "any systemic inquiry conducted by teachers... for the purpose of gathering information about how their particular schools operate, how they teach, and how their students learn" (Mertler, 2009), "action research" is empowering and professional research done by teachers to inform and improves their own practices. Although there are many…

  7. Does Class Size Matter?

    ERIC Educational Resources Information Center

    Ehrenberg, Ronald G.; Brewer, Dominic J.; Gamoran, Adam; Willms, J. Douglas

    2001-01-01

    Reports on the significance of class size to student learning. Includes an overview of class size in various countries, the importance of teacher adaptability, and the Asian paradox of large classes allied to high test scores. (MM)

  8. 48 CFR 13.303-2 - Establishment of BPAs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) After determining a BPA would be advantageous, contracting officers shall— (1) Establish the parameters...-2 Establishment of BPAs. (a) The following are circumstances under which contracting officers may establish BPAs: (1) There is a wide variety of items in a broad class of supplies or services that...

  9. 48 CFR 13.303-2 - Establishment of BPAs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) After determining a BPA would be advantageous, contracting officers shall— (1) Establish the parameters...-2 Establishment of BPAs. (a) The following are circumstances under which contracting officers may establish BPAs: (1) There is a wide variety of items in a broad class of supplies or services that...

  10. 48 CFR 13.303-2 - Establishment of BPAs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) After determining a BPA would be advantageous, contracting officers shall— (1) Establish the parameters...-2 Establishment of BPAs. (a) The following are circumstances under which contracting officers may establish BPAs: (1) There is a wide variety of items in a broad class of supplies or services that...

  11. 48 CFR 13.303-2 - Establishment of BPAs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) After determining a BPA would be advantageous, contracting officers shall— (1) Establish the parameters...-2 Establishment of BPAs. (a) The following are circumstances under which contracting officers may establish BPAs: (1) There is a wide variety of items in a broad class of supplies or services that...

  12. 48 CFR 13.303-2 - Establishment of BPAs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) After determining a BPA would be advantageous, contracting officers shall— (1) Establish the parameters...-2 Establishment of BPAs. (a) The following are circumstances under which contracting officers may establish BPAs: (1) There is a wide variety of items in a broad class of supplies or services that...

  13. 40 CFR 144.55 - Corrective action.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 24 2012-07-01 2012-07-01 false Corrective action. 144.55 Section 144.55 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) UNDERGROUND INJECTION CONTROL PROGRAM Permit Conditions § 144.55 Corrective action. (a) Coverage. Applicants for Class I, II, (other than...

  14. 19 CFR 19.1 - Classes of customs warehouses.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... pens, corrals, or other similar buildings or limited enclosures for the storage of imported animals... domestic consumption. (8) Class 8. Bonded warehouses established for the purpose of cleaning,...

  15. 19 CFR 19.1 - Classes of customs warehouses.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... pens, corrals, or other similar buildings or limited enclosures for the storage of imported animals... domestic consumption. (8) Class 8. Bonded warehouses established for the purpose of cleaning,...

  16. 19 CFR 19.1 - Classes of customs warehouses.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... pens, corrals, or other similar buildings or limited enclosures for the storage of imported animals... domestic consumption. (8) Class 8. Bonded warehouses established for the purpose of cleaning,...

  17. 19 CFR 19.1 - Classes of customs warehouses.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... pens, corrals, or other similar buildings or limited enclosures for the storage of imported animals... domestic consumption. (8) Class 8. Bonded warehouses established for the purpose of cleaning,...

  18. 75 FR 3984 - Establishment of Class D and Class E Airspace, Modification of Class E Airspace; Ocala, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-26

    ... 24, 2009 (74 FR 29939), became effective August 27, 2009. Subsequent to the effective date of the... and E airspace, Ocala, FL in the Federal Register on June 24, 2009 (74 FR 29939), Docket No. FAA- 2009... 0 Accordingly, pursuant to the authority delegated to me, the reference to FAA Order 7400.9 for...

  19. 76 FR 53048 - Amendment of Class D and Class E Airspace and Establishment of Class E Airspace; Casper, WY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-25

    ... Federal Register a notice of proposed rulemaking to amend controlled airspace at Casper, WY (76 FR 36017...'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant... FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in 14 CFR...

  20. 78 FR 18259 - Proposed Modification of Class D and Class E Airspace and Establishment of Class E Airspace...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does... FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in 14 CFR 71.1... or more above the surface of the earth. * * * * * ANM WA E5 Pasco, WA Pasco, Tri-Cities Airport,...

  1. Citizen's actions

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The role played by individual citizens as consumers of energy was examined, with emphasis on studying ways in which their action could result in energy conservation. It was shown that there are ways that energy can be conserved in this way, with citizens acting either individually or in groups. The potential savings are significant, but the actual savings may be quite small. The citizens need to be motivated to save and to believe in a conservation ethic; developing such an ethic is difficult, and perhaps not responsive to the shotgun approach now being attempted. The true course of action may be to synthesize new societal structures that provide the maximum evolution of culture within the limitation of scarce energy resources.

  2. Actionable Nuggets

    PubMed Central

    McColl, Mary Ann; Aiken, Alice; Smith, Karen; McColl, Alexander; Green, Michael; Godwin, Marshall; Birtwhistle, Richard; Norman, Kathleen; Brankston, Gabrielle; Schaub, Michael

    2015-01-01

    Abstract Objective To present the results of a pilot study of an innovative methodology for translating best evidence about spinal cord injury (SCI) for family practice. Design Review of Canadian and international peer-reviewed literature to develop SCI Actionable Nuggets, and a mixed qualitative-quantitative evaluation to determine Nuggets’ effect on physician knowledge of and attitudes toward patients with SCI, as well as practice accessibility. Setting Ontario, Newfoundland, and Australia. Participants Forty-nine primary care physicians. Methods Twenty Actionable Nuggets (pertaining to key health issues associated with long-term SCI) were developed. Nugget postcards were mailed weekly for 20 weeks to participating physicians. Prior knowledge of SCI was self-rated by participants; they also completed an online posttest to assess the information they gained from the Nugget postcards. Participants’ opinions about practice accessibility and accommodations for patients with SCI, as well as the acceptability and usefulness of Nuggets, were assessed in interviews. Main findings With Actionable Nuggets, participants’ knowledge of the health needs of patients with SCI improved, as knowledge increased from a self-rating of fair (58%) to very good (75%) based on posttest quiz results. The mean overall score for accessibility and accommodations in physicians’ practices was 72%. Participants’ awareness of the need for screening and disease prevention among this population also increased. The usefulness and acceptability of SCI Nugget postcards were rated as excellent. Conclusion Actionable Nuggets are a knowledge translation tool designed to provide family physicians with concise, practical information about the most prevalent and pressing primary care needs of patients with SCI. This evidence-based resource has been shown to be an excellent fit with information consumption processes in primary care. They were updated and adapted for distribution by the Canadian

  3. The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: the mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1-naphthylaldehyde benzoyl hydrazone.

    PubMed

    Richardson, D R; Milnes, K

    1997-04-15

    We have recently screened 36 analogues of the lipophilic iron (Fe) chelator, pyridoxal isonicotinoyl hydrazone (PIH), for their antiproliferative effect (Richardson et al, Blood 86:4295, 1995). Of these compounds, 1 chelator derived from salicylaldehyde benzoyl hydrazone (206) and 4 ligands derived from 2-hydroxy-1-naphthylaldehyde benzoyl hydrazone (308, 309, 311, and 315) showed pronounced antiproliferative activity, being far more effective than desferrioxamine (DFO). The present study was designed to investigate in detail the mechanism of action of these PIH analogues in a variety of neoplastic cell lines. This investigation showed that the analogues were far more active than DFO at inhibiting cellular proliferation and 3H-thymidine, 3H-leucine, and 3H-uridine incorporation. Additional experiments showed that, in contrast to DFO, the 5 analogues were potent at preventing 59Fe uptake from transferrin (Tf) and increasing 59Fe release from cells at concentrations as low as 10 micromol/L. Examination of the distribution of 59Fe in neoplastic cells using native polyacrylamide gel electrophoresis (PAGE)/59Fe-autoradiography showed that most of the 59Fe taken up from Tf was incorporated into ferritin, although 3 other previously unrecognized components (bands A, B, and C) were also identified. Band C comigrated with 59Fe-citrate and was chelated on incubation of neuroblastoma cells with DFO, PIH, or the PIH analogues, with this compartment being the main intracellular target of these ligands. Further work showed that the effects of the chelators at inducing characteristics consistent with apoptosis or necrosis were cell line-specific, and while DFO increased the percentage of cells in the G0/G1 phases in all cell types, the effect of analogue 311 on the cell cycle was variable depending on the cell line. This study provides further evidence for the potential use of these Fe chelators as anticancer agents.

  4. A Novel Way to Relate Ontology Classes

    PubMed Central

    Choksi, Ami T.; Jinwala, Devesh C.

    2015-01-01

    The existing ontologies in the semantic web typically have anonymous union and intersection classes. The anonymous classes are limited in scope and may not be part of the whole inference process. The tools, namely, the pellet, the jena, and the protégé, interpret collection classes as (a) equivalent/subclasses of union class and (b) superclasses of intersection class. As a result, there is a possibility that the tools will produce error prone inference results for relations, namely, sub-, union, intersection, equivalent relations, and those dependent on these relations, namely, complement. To verify whether a class is complement of other involves utilization of sub- and equivalent relations. Motivated by the same, we (i) refine the test data set of the conference ontology by adding named, union, and intersection classes and (ii) propose a match algorithm to (a) calculate corrected subclasses list, (b) correctly relate intersection and union classes with their collection classes, and (c) match union, intersection, sub-, complement, and equivalent classes in a proper sequence, to avoid error prone match results. We compare the results of our algorithms with those of a candidate reasoner, namely, the pellet reasoner. To the best of our knowledge, ours is a unique attempt in establishing a novel way to relate ontology classes. PMID:25984560

  5. A novel way to relate ontology classes.

    PubMed

    Choksi, Ami T; Jinwala, Devesh C

    2015-01-01

    The existing ontologies in the semantic web typically have anonymous union and intersection classes. The anonymous classes are limited in scope and may not be part of the whole inference process. The tools, namely, the pellet, the jena, and the protégé, interpret collection classes as (a) equivalent/subclasses of union class and (b) superclasses of intersection class. As a result, there is a possibility that the tools will produce error prone inference results for relations, namely, sub-, union, intersection, equivalent relations, and those dependent on these relations, namely, complement. To verify whether a class is complement of other involves utilization of sub- and equivalent relations. Motivated by the same, we (i) refine the test data set of the conference ontology by adding named, union, and intersection classes and (ii) propose a match algorithm to (a) calculate corrected subclasses list, (b) correctly relate intersection and union classes with their collection classes, and (c) match union, intersection, sub-, complement, and equivalent classes in a proper sequence, to avoid error prone match results. We compare the results of our algorithms with those of a candidate reasoner, namely, the pellet reasoner. To the best of our knowledge, ours is a unique attempt in establishing a novel way to relate ontology classes.

  6. Conscious Action/Zombie Action

    PubMed Central

    Shepherd, Joshua

    2015-01-01

    Abstract I argue that the neural realizers of experiences of trying (that is, experiences of directing effort towards the satisfaction of an intention) are not distinct from the neural realizers of actual trying (that is, actual effort directed towards the satisfaction of an intention). I then ask how experiences of trying might relate to the perceptual experiences one has while acting. First, I assess recent zombie action arguments regarding conscious visual experience, and I argue that contrary to what some have claimed, conscious visual experience plays a causal role for action control in some circumstances. Second, I propose a multimodal account of the experience of acting. According to this account, the experience of acting is (at the very least) a temporally extended, co‐conscious collection of agentive and perceptual experiences, functionally integrated and structured both by multimodal perceptual processing as well as by what an agent is, at the time, trying to do. PMID:27667859

  7. Conscious Action/Zombie Action

    PubMed Central

    Shepherd, Joshua

    2015-01-01

    Abstract I argue that the neural realizers of experiences of trying (that is, experiences of directing effort towards the satisfaction of an intention) are not distinct from the neural realizers of actual trying (that is, actual effort directed towards the satisfaction of an intention). I then ask how experiences of trying might relate to the perceptual experiences one has while acting. First, I assess recent zombie action arguments regarding conscious visual experience, and I argue that contrary to what some have claimed, conscious visual experience plays a causal role for action control in some circumstances. Second, I propose a multimodal account of the experience of acting. According to this account, the experience of acting is (at the very least) a temporally extended, co‐conscious collection of agentive and perceptual experiences, functionally integrated and structured both by multimodal perceptual processing as well as by what an agent is, at the time, trying to do.

  8. Class IId or Linear and Non-Pediocin-Like Bacteriocins

    NASA Astrophysics Data System (ADS)

    Iwatani, Shun; Zendo, Takeshi; Sonomoto, Kenji

    Class IId bacteriocins are one of the subclasses of class II bacteriocins produced by lactic acid bacteria. This class of bacteriocins, however, show a great diversity in their primary structures and modes of action. This chapter focuses on two aspects: (1) the description of those heterogeneous bacteriocins with the concept of three potential subgroups and (2) the modes of action of lactococcin A, lactococcin 972, and lacticin Q, each of which belongs to a different subgroup and is well characterized in its unique mode of action.

  9. 75 FR 35766 - Establishment of the Renewable Energy and Energy Efficiency Advisory Committee and Solicitation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-23

    ... International Trade Administration Establishment of the Renewable Energy and Energy Efficiency Advisory.... ACTION: Notice of establishment of the Renewable Energy and Energy Efficiency Advisory Committee and... establishment of the Renewable Energy and Energy Efficiency Advisory Committee (the Committee) by the...

  10. Action Learning: Avoiding Conflict or Enabling Action

    ERIC Educational Resources Information Center

    Corley, Aileen; Thorne, Ann

    2006-01-01

    Action learning is based on the premise that action and learning are inextricably entwined and it is this potential, to enable action, which has contributed to the growth of action learning within education and management development programmes. However has this growth in action learning lead to an evolution or a dilution of Revan's classical…

  11. Focus on California's Class-Size Reduction: Smaller Classes Aim To Launch Early Literacy.

    ERIC Educational Resources Information Center

    McRobbie, Joan

    Smaller class sizes in California were viewed as a way to improve K-3 education, especially in the area of literacy. The urgency to act prompted state leaders to adopt class-size reduction (CSR) without knowing for sure that it would work and without establishing a formal procedure for evaluating the program. This report looks at past research on…

  12. Establishing American Colleges Abroad.

    ERIC Educational Resources Information Center

    Greene, William E.

    1990-01-01

    Describes the growing involvement of U.S. two-year colleges in establishing programs abroad to enable foreign students to complete one or two years of college-level work in their home country before transferring to U.S. universities. Highlights the activities of several community colleges in the Pacific Rim. Identifies conditions basic to future…

  13. 48 CFR 2901.404 - Class deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... through the Director, DAMS. (b) Requests for deviations under paragraph (a) of this section must be... contracting actions which will be affected. (c) For a FAR class deviation the Director, DAMS will consult with... Director, DAMS as required in FAR 1.404....

  14. 40 CFR 300.800 - Establishment of an administrative record.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS NATIONAL OIL AND HAZARDOUS SUBSTANCES POLLUTION CONTINGENCY PLAN Administrative Record for Selection of Response Action § 300.800 Establishment...

  15. 40 CFR 300.800 - Establishment of an administrative record.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS NATIONAL OIL AND HAZARDOUS SUBSTANCES POLLUTION CONTINGENCY PLAN Administrative Record for Selection of Response Action § 300.800 Establishment...

  16. 40 CFR 300.800 - Establishment of an administrative record.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS NATIONAL OIL AND HAZARDOUS SUBSTANCES POLLUTION CONTINGENCY PLAN Administrative Record for Selection of Response Action § 300.800 Establishment...

  17. 40 CFR 300.800 - Establishment of an administrative record.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS NATIONAL OIL AND HAZARDOUS SUBSTANCES POLLUTION CONTINGENCY PLAN Administrative Record for Selection of Response Action § 300.800 Establishment...

  18. 40 CFR 300.800 - Establishment of an administrative record.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS NATIONAL OIL AND HAZARDOUS SUBSTANCES POLLUTION CONTINGENCY PLAN Administrative Record for Selection of Response Action § 300.800 Establishment...

  19. The Quench Action

    NASA Astrophysics Data System (ADS)

    Caux, Jean-Sébastien

    2016-06-01

    We give a pedagogical introduction to the methodology of the Quench Action, which is an effective representation for the calculation of time-dependent expectation values of physical operators following a generic out-of-equilibrium state preparation protocol (for example a quantum quench). The representation, originally introduced in Caux and Essler (2013 Phys. Rev. Lett. 110 257203), is founded on a mixture of exact data for overlaps together with variational reasonings. It is argued to be quite generally valid and thermodynamically exact for arbitrary times after the quench (from short times all the way up to the steady state), and applicable to a wide class of physically relevant observables. Here, we introduce the method and its language, give an overview of some recent results, suggest a roadmap and offer some perspectives on possible future research directions.

  20. Embracing causality in specifying the indeterminate effects of actions

    SciTech Connect

    Lin, F.

    1996-12-31

    This paper makes the following two contributions to formal theories of actions: Showing that a causal minimization framework can be used effectively to specify the effects of indeterminate actions; and showing that for certain classes of such actions, regression, an effective computational mechanism, can be used to reason about them.

  1. Establishment of Intestinal Bacteriology

    PubMed Central

    MITSUOKA, Tomotari

    2014-01-01

    Research on intestinal bacteria began around the end of the 19th century. During the last 5 decades of the 20th century, research on the intestinal microbiota made rapid progress. At first, in my work, I first developed a method of comprehensive analysis of the intestinal microbiota, and then I established classification and identification methods for intestinal anaerobes. Using these methods I discovered a number of ecological rules governing the intestinal microbiota and the role of the intestinl microbiota in health and disease. Moreover, using germfree animals, it was proven that the intestinal microbiota has a role in carcinogenesis and aging in the host. Thus, a new interdisciplinary field, “intestinal bacteriology” was established. PMID:25032084

  2. Pilot Class Testing: Statistics.

    ERIC Educational Resources Information Center

    Washington Univ., Seattle. Washington Foreign Language Program.

    Statistics derived from test score data from the pilot classes participating in the Washington Foreign Language Program are presented in tables in this report. An index accompanies the tables, itemizing the classes by level (FLES, middle, and high school), grade test, language skill, and school. MLA-Coop test performances for each class were…

  3. First-Class Inquiry

    ERIC Educational Resources Information Center

    Hesser, Kathi; Buck, Gayle; Dopp, Sandra

    2005-01-01

    In the activity described in this article, students will explore how variables in a first-class lever, specifically arm length, position of the fulcrum, and placement of the load, affect the effort needed to lift the load. To begin the lesson, demonstrate to the class how a first-class lever works and review what is meant by the terms fulcrum,…

  4. Girls' Class, Infinite Possibilities.

    ERIC Educational Resources Information Center

    Ost, Nancy

    1999-01-01

    The co-director of a small independent school describes Girls' Class, which she created in order to have a special time together with the girls in grades 6 through 8. The class provides guidance and celebrates spirituality and the beginning of menses for the young women. To end the class, each person says a positive self-affirmation and gives…

  5. Less chalk more action

    NASA Astrophysics Data System (ADS)

    Mitriceski Andelkovic, Bojana; Jovic, Sladjana

    2016-04-01

    Less chalk more action Education should not be a mechanical system that operates according to the principles of the orders and implementation. Education should respect the basic laws of the develop and progress. Curiosity is the engine of achievement and children spontaneously and happily learn only if they get interested, if teacher wake up and stimulate their creativity and individuality. We would like to present classes that are realized as thematic teaching with several subjects involved: chemistry, geography, math, art and biology. Classes were organized for students at age from 10 to 13 years, every month during autumn and winter 2015. Better students identified themselves as teachers and presented peer education .Teachers were monitoring the process of teaching and help to develop links between younger and older students, where older students were educators to younger students. Also one student with special needs was involved in this activities and was supported by other students during the workshops The benefit from this project will be represented with evaluation marks. Evaluation table shows that group of ten students(age 10 to13 years) which are selected in October as children with lack of motivation for learning, got better marks, at the end of January , then they had it in the beginning of the semester.

  6. Empirical microeconomics action functionals

    NASA Astrophysics Data System (ADS)

    Baaquie, Belal E.; Du, Xin; Tanputraman, Winson

    2015-06-01

    A statistical generalization of microeconomics has been made in Baaquie (2013), where the market price of every traded commodity, at each instant of time, is considered to be an independent random variable. The dynamics of commodity market prices is modeled by an action functional-and the focus of this paper is to empirically determine the action functionals for different commodities. The correlation functions of the model are defined using a Feynman path integral. The model is calibrated using the unequal time correlation of the market commodity prices as well as their cubic and quartic moments using a perturbation expansion. The consistency of the perturbation expansion is verified by a numerical evaluation of the path integral. Nine commodities drawn from the energy, metal and grain sectors are studied and their market behavior is described by the model to an accuracy of over 90% using only six parameters. The paper empirically establishes the existence of the action functional for commodity prices that was postulated to exist in Baaquie (2013).

  7. The prediction of toxic mode of action for environmental pollutants based on physico-chemical properties

    SciTech Connect

    Boxall, A.B.A. |; Watts, C.D.; Bresnen, G.M.; Dearden, J.C.; Scoffin, R.

    1995-12-31

    Aquatic ecosystems receive a wide range of potentially toxic contaminants. One approach to measure the environmental impact of these compounds is to perform costly and detailed experimental investigations. A quick and cost-effective alternative is to predict the likely effects of chemical contaminants using quantitative structure activity relationships (QSARs) which relate effects to chemical structure. One problem with the predictive approach is that QSARs can be established and used only for compounds with a common mode of toxic action. It is therefore important that a compound is assigned to the correct mode of action and that the correct QSAR is used. Two kinds of approach can be used to address this problem. In the first a compound is assigned to a class based on responses observed during experimental tests. The other approach uses chemical structural information e.g. the OECD method where compounds are classed as inert, less inert, reactive or specific acting based on chemical structure. The objective of this study was to determine whether compounds could be classified into one of the four OECD classes solely on the basis of their physico-chemical properties. Approximately 800 compounds were assigned to an OECD class and a range of properties were calculated. Discriminant analysis demonstrated that a large proportion of these compounds could be classified correctly based on two properties, namely a molecular connectivity index ({sup 2}{sub x}) and an electronic parameter (E{sub HOMO}).

  8. 48 CFR 1.703 - Class determinations and findings.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... findings. 1.703 Section 1.703 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Determinations and Findings 1.703 Class determinations and findings... identical justification. (b) The findings in a class D&F shall fully support the proposed action either...

  9. 48 CFR 1.703 - Class determinations and findings.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... findings. 1.703 Section 1.703 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Determinations and Findings 1.703 Class determinations and findings... identical justification. (b) The findings in a class D&F shall fully support the proposed action either...

  10. 48 CFR 1.703 - Class determinations and findings.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... findings. 1.703 Section 1.703 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Determinations and Findings 1.703 Class determinations and findings... identical justification. (b) The findings in a class D&F shall fully support the proposed action either...

  11. 48 CFR 1.703 - Class determinations and findings.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... findings. 1.703 Section 1.703 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Determinations and Findings 1.703 Class determinations and findings... identical justification. (b) The findings in a class D&F shall fully support the proposed action either...

  12. 48 CFR 1.703 - Class determinations and findings.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... findings. 1.703 Section 1.703 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Determinations and Findings 1.703 Class determinations and findings... identical justification. (b) The findings in a class D&F shall fully support the proposed action either...

  13. 76 FR 71610 - Market Test of First-Class Tracer

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-18

    ... Market Test of First-Class Tracer AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is noticing a recently-field Postal Service proposal to conduct a market test of a market dominant product, First- Class Tracer. This document describes the proposed test, addresses procedural aspects...

  14. Dynamic Leadership, Character Education Form New FCS Class

    ERIC Educational Resources Information Center

    Watkins, Carol Ann

    2007-01-01

    In this article, the author describes the leadership class that she created for the family and consumer sciences (FCS) department. The class, "Family & Consumer Sciences Issues & Applications," focused on family and community action for improved quality of life. It included in-depth laboratory experiences, service learning activities, and the…

  15. Women as Civic Volunteers in the Working Class Community.

    ERIC Educational Resources Information Center

    Dabrowski, Irene

    This study investigates how 40 working-class women participate as volunteers in the service, political, and social action arenas of their community--Carondelet, on the South Side of St. Louis. The purpose is to show that working-class women who live in transitional areas are capable of politically addressing the urban problems intruding into their…

  16. LIGA Micromachining: Infrastructure Establishment

    SciTech Connect

    Alfredo M. Morales; Barry V. Hess; Dale R. Boehme; Jill M. Hruby; John S. Krafcik; Robert H. Nilson; Stewart K. Griffiths; William D. Bonivert

    1999-02-01

    LIGA is a micromachining technology that uses high energy x-rays from a synchrotron to create patterns with small lateral dimensions in a deep, non-conducting polymeric resist. Typical dimensions for LIGA parts are microns to tens of microns in lateral size, and hundreds of microns to millimeters in depth. Once the resist is patterned, metal is electrodeposited in the features to create metal microparts, or to create a metal mold for subsequent replication. The acronym LIGA comes from the German words for lithography, electroforming, and molding, and the technology has been under worldwide development for more than a decade. over the last five years, a full-service capability to produce metal microparts using the LIGA process has been established at Sandia national Laboratories, California. This report describes the accomplishments made during the past two years in infrastructure establishment funded by a Laboratory Directed Research and Development (LDRD) project entitled ''LIGA Micromachining.'' Specific topics include photoresist processing for LIGA mask making, x-ray scanning equipment, plating bath instrumentation, plating uniformity, and software architecture.

  17. State Action Analysis of Tax Expenditures

    ERIC Educational Resources Information Center

    Brown, Robert Clarke

    1977-01-01

    Recent judicial treatment of tax expenditures in both state action and establishment clause cases is analyzed and it is argued that tax expenditures and direct expenditures should be treated as constitutional equivalents. (LBH)

  18. How Class Size Makes a Difference: What the Research Says. The Impact of Class-Size Reduction (CSR).

    ERIC Educational Resources Information Center

    Achilles, C. M.

    Class size in elementary grades has taken on added importance recently. Research on the topic is finally getting some attention. Legislative and administrative actions to reduce deficits are pushing for larger class sizes, in addition to eliminating nonessential curricular activities, such as music, drama, and art. In Florida, various institutions…

  19. 78 FR 63861 - Modification of Class B Airspace; Minneapolis, MN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-25

    ... Class B airspace area (78 FR 10564). This action proposed to expand the lateral boundaries and lower... follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp..., MN AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This...

  20. Establishing effective working relationships.

    PubMed

    Houghton, Trish

    2016-02-24

    This article, the second in a series of 11, provides support and offers advice to new and existing mentors and practice teachers to enable them to progress in their role and develop a portfolio of evidence. In particular, the article discusses how to establish effective working relationships and emphasises the importance of the student-mentor or student-practice teacher relationship. It examines the essential qualities, attributes and characteristics of an effective mentor or practice teacher. The article provides learning activities and suggests ways in which mentors and practice teachers can undertake various self-assessments, enabling them to gather relevant evidence to demonstrate how they can meet and maintain the requirements for these roles as stipulated by the Nursing and Midwifery Council.