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Sample records for action investigation cai

  1. The Formation Of The First Solids In The Solar System: An Investigation Of CAI Diversity

    NASA Astrophysics Data System (ADS)

    Taillifet, Esther; Baillié, K.; Charnoz, S.; Aléon, J.

    2012-10-01

    Chondritic meteorites are primitive bodies and therefore an important source of information on the first moments of planets formation. Chondrites contain several materials especially calcium and aluminum rich inclusions (CAIs), known to be the oldest objects of the solar system (4.567 Gyr - Amelin et al., 2002; Connelly et al., 2008) and thus the first solids to be formed. CAIs appear in various textures, sizes and compositions in chondrites. Though, all of them should have formed at high temperature (1300-1800 K) in the same region of the solar nebula by condensation from the gas (e.g. Grossman, 1972; Yoneda & Grossman, 1995; Petaev & Wood, 1998; Ebel & Grossman 2000). To answer this problem we study the CAI formation within the solar nebula using numerical simulations. For this work we developed a self consistent thermodynamical model of the solar nebula (see associated talk from Baillié et. al ) based on previous works (Calvet et. al, 1991; Hueso & Guillot, 2005; Dullemond, Dominik and Natta, 2001). Using this model, we simulate the young system with Lagrangian Implicit Disk Transport code (LIDT - Charnoz et. al, 2010). We will focus on the very first instants of the CAIs within the few years following their condensation. We will report our first results in terms of thermal history and investigate if turbulence-driven transport may explain the CAI diversity.

  2. Petrological Investigations of CAIs from Efremovka and NWA 3118 CV3 Chondrites

    NASA Astrophysics Data System (ADS)

    Ivanova, M. A.; Lorenz, C. A.; Korochantseva, E. V.; MacPherson, G. J.

    2010-03-01

    Several new big CAIs were extracted from the Efremovka and NWA 3118 CV3 chondrites to analyze petrology, chemistry and isotopic compositions. Here we report preliminary results on mineralogy, petrology and bulk chemistry of two CAIs, of Type B1 and of Type A.

  3. Microstructural Investigation of a Wark-Lovering Rim on a Vigarano CAI

    NASA Technical Reports Server (NTRS)

    Han, J.; Keller, L. P.; Needham, A. W.; Messenger, S.; Simon, J. I.

    2015-01-01

    Wark-Lovering (WL) rims are thin multi-layered mineral sequences that surround many CAIs. These rim layers consist of the primary minerals found in the CAI interiors, but vary in their mineralogy. Several models for their origin have been proposed including condensation, reaction with a nebular gas, evaporation, or combinations of these. However, there still is little consensus on how and when the rims formed. Here, we describe the microstructure and mineralogy of a WL rim on a type B CAI from the Vigarano CV(sub red) chondrite using FIB/TEM to better understand the astrophysical significance of WL rim formation.

  4. Numerical investigation of CAI Combustion in the Opposed- Piston Engine with Direct and Indirect Water Injection

    NASA Astrophysics Data System (ADS)

    Pyszczek, R.; Mazuro, P.; Teodorczyk, A.

    2016-09-01

    This paper is focused on the CAI combustion control in a turbocharged 2-stroke Opposed-Piston (OP) engine. The barrel type OP engine arrangement is of particular interest for the authors because of its robust design, high mechanical efficiency and relatively easy incorporation of a Variable Compression Ratio (VCR). The other advantage of such design is that combustion chamber is formed between two moving pistons - there is no additional cylinder head to be cooled which directly results in an increased thermal efficiency. Furthermore, engine operation in a Controlled Auto-Ignition (CAI) mode at high compression ratios (CR) raises a possibility of reaching even higher efficiencies and very low emissions. In order to control CAI combustion such measures as VCR and water injection were considered for indirect ignition timing control. Numerical simulations of the scavenging and combustion processes were performed with the 3D CFD multipurpose AVL Fire solver. Numerous cases were calculated with different engine compression ratios and different amounts of directly and indirectly injected water. The influence of the VCR and water injection on the ignition timing and engine performance was determined and their application in the real engine was discussed.

  5. An investigative study into the effectiveness of using computer-aided instruction (CAI) as a laboratory component of college-level biology: A case study

    NASA Astrophysics Data System (ADS)

    Barrett, Joan Beverly

    Community colleges serve the most diverse student populations in higher education. They consist of non-traditional, part-time, older, intermittent, and mobile students of different races, ethnic backgrounds, language preferences, physical and mental abilities, and learning style preferences. Students who are academically challenged may have diverse learning characteristics that are not compatible with the more traditional approaches to the delivery of instruction. With this need come new ways of solving the dilemma, such as Computer-aided Instruction (CAI). This case study investigated the use of CAI as a laboratory component of college-level biology in a small, rural community college setting. The intent was to begin to fill a void that seems to exist in the literature regarding the role of the faculty in the development and use of CAI. In particular, the investigator was seeking to understand the practice and its effectiveness, especially in helping the under prepared student. The case study approach was chosen to examine a specific phenomenon within a single institution. Ethnographic techniques, such as interviewing, documentary analysis, life's experiences, and participant observations were used to collect data about the phenomena being studied. Results showed that the faculty was primarily self-motivated and self-taught in their use of CAI as a teaching and learning tool. The importance of faculty leadership and collegiality was evident. Findings showed the faculty confident that expectations of helping students who have difficulties with mathematical concepts have been met and that CAI is becoming the most valuable of learning tools. In a traditional college classroom, or practice, time is the constant (semesters) and competence is the variable. In the CAI laboratory time became the variable and competence the constant. The use of CAI also eliminated hazardous chemicals that were routinely used in the more traditional lab. Outcomes showed that annual savings

  6. Clean slate corrective action investigation plan

    SciTech Connect

    1996-05-01

    The Clean Slate sites discussed in this report are situated in the central portion of the Tonopah Test Range (TTR), north of the Nevada Test Site (NTS) on the northwest portion of the Nellis Air Force Range (NAFR) which is approximately 390 kilometers (km) (240 miles [mi]) northwest of Las Vegas, Nevada. These sites were the locations for three of the four Operation Roller Coaster experiments. These experiments evaluated the dispersal of plutonium in the environment from the chemical explosion of a plutonium-bearing device. Although it was not a nuclear explosion, Operation Roller Coaster created some surface contamination which is now the subject of a corrective action strategy being implemented by the Nevada Environmental Restoration Project (NV ERP) for the U.S. Department of Energy (DOE). Corrective Action Investigation (CAI) activities will be conducted at three of the Operation Roller Coaster sites. These are Clean Slate 1 (CS-1), Clean Slate 2 (CS-2), and Clean Slate 3 (CS-3) sites, which are located on the TTR. The document that provides or references all of the specific information relative to the various investigative processes is called the Corrective Action Investigation Plan (CAIP). This CAIP has been prepared for the DOE Nevada Operations Office (DOE/NV) by IT Corporation (IT).

  7. Corrective Action Investigation Plan for Corrective Action Unit 563: Septic Systems, Nevada Test Site, Nevada, with Errata Sheet, Revision 0

    SciTech Connect

    Alfred Wickline

    2007-01-01

    Corrective Action Unit 563, Septic Systems, is located in Areas 3 and 12 of the Nevada Test Site, which is 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 563 is comprised of the four corrective action sites (CASs) below: • 03-04-02, Area 3 Subdock Septic Tank • 03-59-05, Area 3 Subdock Cesspool • 12-59-01, Drilling/Welding Shop Septic Tanks • 12-60-01, Drilling/Welding Shop Outfalls These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation (CAI) before evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document.

  8. Corrective Action Investigation Plan for Corrective Action Unit 98: Frenchman Flat, Nevada Test Site, Nevada (Revision 1)

    SciTech Connect

    USDOE /NV

    1999-07-01

    This Corrective Action Investigation Plan (CAIP) has been developed for Frenchman Flat Corrective Action Unit (CAU) 98. The Frenchman Flat CAU is located along the eastern border of the Nevada Test Site (NTS) and includes portions of Areas 5 and 11. The Frenchman Flat CAU constitutes one of several areas of the Nevada Test Site used for underground nuclear testing in the past. The nuclear tests resulted in groundwater contamination in the vicinity as well as downgradient of the underground test areas. The CAIP describes the Corrective Action Investigation (CAI) to be conducted at the Frenchman Flat CAU to evaluate the extent of contamination in groundwater due to the underground nuclear testing. The Frenchman Flat CAI will be conducted by the Underground Test Area (UGTA) Project which is a part of the U.S. Department of Energy, Nevada Operations Office (DOE/NV) Environmental Restoration Project. The CAIP is a requirement of the Federal Facility Agreement and Consent Order (FFACO) (1996 ) agreed to by the U.S. Department of Energy (DOE), the Nevada Division of Environmental Protection (NDEP), and the U.S. Department of Defense (DoD). Based on the general definition of a CAI from Section IV.14 of the FFACO, the purpose of the CAI is ''...to gather data sufficient to characterize the nature, extent, and rate of migration or potential rate of migration from releases or discharges of pollutants or contaminants and/or potential releases or discharges from corrective action units identified at the facilities...'' (FFACO, 1996). However, for the Underground Test Area (UGTA) CAUs, ''...the objective of the CAI process is to define boundaries around each UGTA CAU that establish areas that contain water that may be unsafe for domestic and municipal use.'', as stated in Appendix VI of the FFACO (1996). According to the UGTA strategy (Appendix VI of the FFACO), the CAI of a given CAU starts with the evaluation of the existing data. New data collection activities are generally

  9. Developing Large CAI Packages.

    ERIC Educational Resources Information Center

    Reed, Mary Jac M.; Smith, Lynn H.

    1983-01-01

    When developing large computer-assisted instructional (CAI) courseware packages, it is suggested that there be more attentive planning to the overall package design before actual lesson development is begun. This process has been simplified by modifying the systems approach used to develop single CAI lessons, followed by planning for the…

  10. CAI Terminal Characteristics.

    ERIC Educational Resources Information Center

    Braun, Peter

    The bewildering number of available terminals which are offered to CAI users presents a rather formidable problem of which one to choose. This article surveys what appear to be evolving standards for terminals. The usefulness of these terminals for CAI purposes is discussed, together with the best known prototype exhibiting the particular feature.…

  11. Carbon, CAIs and chondrules

    NASA Technical Reports Server (NTRS)

    Ash, R. D.; Russell, S. S.

    1994-01-01

    It has been shown that C is present in CAI's and chondrules. It can be distinguished from matrix C both by its thermal stability and isotopic composition, which implies that it was not introduced after parent body accretion. It is concluded that C must have been present in the chondrule and CAI precursor material. Therefore any models of chondrule and CAI formation and inferences drawn about solar system conditions during these events must take into account the consequences of the presence of C on inclusion chemistry, mineralogy, and oxidation state.

  12. Corrective Action Investigation Plan for Corrective Action Unit 137: Waste Disposal Sites, Nevada Test Site, Nevada, Rev. No.:0

    SciTech Connect

    Wickline, Alfred

    2005-12-01

    This Corrective Action Investigation Plan (CAIP) contains project-specific information including facility descriptions, environmental sample collection objectives, and criteria for conducting site investigation activities at Corrective Action Unit (CAU) 137: Waste Disposal Sites. This CAIP has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996) that was agreed to by the State of Nevada, the U.S. Department of Energy (DOE), and the U.S. Department of Defense. Corrective Action Unit 137 contains sites that are located in Areas 1, 3, 7, 9, and 12 of the Nevada Test Site (NTS), which is approximately 65 miles (mi) northwest of Las Vegas, Nevada (Figure 1-1). Corrective Action Unit 137 is comprised of the eight corrective action sites (CASs) shown on Figure 1-1 and listed below: (1) CAS 01-08-01, Waste Disposal Site; (2) CAS 03-23-01, Waste Disposal Site; (3) CAS 03-23-07, Radioactive Waste Disposal Site; (4) CAS 03-99-15, Waste Disposal Site; (5) CAS 07-23-02, Radioactive Waste Disposal Site; (6) CAS 09-23-07, Radioactive Waste Disposal Site; (7) CAS 12-08-01, Waste Disposal Site; and (8) CAS 12-23-07, Waste Disposal Site. The Corrective Action Investigation (CAI) will include field inspections, radiological surveys, geophysical surveys, sampling of environmental media, analysis of samples, and assessment of investigation results, where appropriate. Data will be obtained to support corrective action alternative evaluations and waste management decisions. The CASs in CAU 137 are being investigated because hazardous and/or radioactive constituents may be present in concentrations that could potentially pose a threat to human health and the environment. Existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives for the CASs. Additional information will be generated by conducting a CAI before evaluating and selecting corrective action

  13. Corrective Action Investigation Plan for Corrective Action Unit 555: Septic Systems Nevada Test Site, Nevada, Rev. No.: 0 with Errata

    SciTech Connect

    Pastor, Laura

    2005-12-01

    This Corrective Action Investigation Plan (CAIP) contains project-specific information including facility descriptions, environmental sample collection objectives, and criteria for conducting site investigation activities at Corrective Action Unit (CAU) 555: Septic Systems, Nevada Test Site (NTS), Nevada. This CAIP has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996) that was agreed to by the State of Nevada, the U.S. Department of Energy (DOE), and the U.S. Department of Defense. Corrective Action Unit 555 is located in Areas 1, 3 and 6 of the NTS, which is approximately 65 miles (mi) northwest of Las Vegas, Nevada, and is comprised of the five corrective action sites (CASs) shown on Figure 1-1 and listed below: (1) CAS 01-59-01, Area 1 Camp Septic System; (2) CAS 03-59-03, Core Handling Building Septic System; (3) CAS 06-20-05, Birdwell Dry Well; (4) CAS 06-59-01, Birdwell Septic System; and (5) CAS 06-59-02, National Cementers Septic System. An FFACO modification was approved on December 14, 2005, to include CAS 06-20-05, Birdwell Dry Well, as part of the scope of CAU 555. The work scope was expanded in this document to include the investigation of CAS 06-20-05. The Corrective Action Investigation (CAI) will include field inspections, radiological surveys, geophysical surveys, sampling of environmental media, analysis of samples, and assessment of investigation results, where appropriate. Data will be obtained to support corrective action alternative evaluations and waste management decisions. The CASs in CAU 555 are being investigated because hazardous and/or radioactive constituents may be present in concentrations that could potentially pose a threat to human health and the environment. Existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives for the CASs. Additional information will be generated by conducting a CAI

  14. Corrective Action Investigation plan for Corrective Action Unit 546: Injection Well and Surface Releases, Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Alfred Wickline

    2008-03-01

    Corrective Action Unit (CAU) 546 is located in Areas 6 and 9 of the Nevada Test Site, which is approximately 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 546 is comprised of two Corrective Action Sites (CASs) listed below: •06-23-02, U-6a/Russet Testing Area •09-20-01, Injection Well These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation (CAI) before evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on November 8, 2007, by representatives of the Nevada Division of Environmental Protection and U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office. The DQO process has been used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 546.

  15. Skill Specific CAI Techniques.

    ERIC Educational Resources Information Center

    Lavine, Roberta Z.; Fechter, Sharon Ahern

    Advantages of computer-assisted instruction (CAI) for grammar-oriented exercises are considered, and a learning module to help the student prepare for the Test of English as a Foreign Language (TOEFL) exam is described. The exercises are modeled on the TOEFL exam: the student is given a sentence, one part of which is incorrect and is asked to…

  16. Corrective Action Investigation Plan for Corrective Action Unit 190: Contaminated Waste Sites Nevada Test Site, Nevada, Rev. No.: 0

    SciTech Connect

    Wickline, Alfred

    2006-12-01

    Corrective Action Unit (CAU) 190 is located in Areas 11 and 14 of the Nevada Test Site, which is 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 190 is comprised of the four Corrective Action Sites (CASs) listed below: (1) 11-02-01, Underground Centrifuge; (2) 11-02-02, Drain Lines and Outfall; (3) 11-59-01, Tweezer Facility Septic System; and (4) 14-23-01, LTU-6 Test Area. These sites are being investigated because existing information is insufficient on the nature and extent of potential contamination to evaluate and recommend corrective action alternatives. Additional information will be obtained before evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS by conducting a corrective action investigation (CAI). The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on August 24, 2006, by representatives of the Nevada Division of Environmental Protection; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; Stoller-Navarro Joint Venture, and National Security Technologies, LLC. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 190. The scope of the CAU 190 CAI includes the following activities: (1) Move surface debris and/or materials, as needed, to facilitate sampling; (2) Conduct radiological and geophysical surveys; (3) Perform field screening; (4) Collect and submit environmental samples for laboratory analysis to determine whether contaminants of concern (COCs) are present; (5) If COCs are present, collect additional step-out samples to define the lateral and vertical extent of the contamination; (6) Collect samples of source material, if present

  17. Corrective Action Investigation Plan for Corrective Action Unit 145: Wells and Storage Holes, Nevada Test Site, Nevada, Rev. No.: 0

    SciTech Connect

    David A. Strand

    2004-09-01

    This Corrective Action Investigation Plan (CAIP) contains project-specific information for conducting site investigation activities at Corrective Action Unit (CAU) 145: Wells and Storage Holes. Information presented in this CAIP includes facility descriptions, environmental sample collection objectives, and criteria for the selection and evaluation of environmental samples. Corrective Action Unit 145 is located in Area 3 of the Nevada Test Site, which is 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 145 is comprised of the six Corrective Action Sites (CASs) listed below: (1) 03-20-01, Core Storage Holes; (2) 03-20-02, Decon Pad and Sump; (3) 03-20-04, Injection Wells; (4) 03-20-08, Injection Well; (5) 03-25-01, Oil Spills; and (6) 03-99-13, Drain and Injection Well. These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation (CAI) prior to evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document. One conceptual site model with three release scenario components was developed for the six CASs to address all releases associated with the site. The sites will be investigated based on data quality objectives (DQOs) developed on June 24, 2004, by representatives of the Nevada Division of Environmental Protection; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; Stoller-Navarro Joint Venture; and Bechtel Nevada. The DQOs process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 145.

  18. A CAI Approach to Teaching an Office Technology Course.

    ERIC Educational Resources Information Center

    D'Souza, Patricia Veasey

    1989-01-01

    Describes study that investigated the difference between computer-assisted instruction (CAI) and traditional lecture instruction in teaching an office technology course. The effects of CAI on student achievement and student attitudes is discussed, hypotheses tested and pretests and posttests are described, and further research needs are suggested.…

  19. Corrective Action Investigation Plan for Corrective Action Unit 309: Area 12 Muckpiles, Nevada Test Site, Nevada, Rev. No.: 0

    SciTech Connect

    David A. Strand

    2004-12-01

    This Corrective Action Investigation Plan (CAIP) contains project-specific information including facility descriptions, environmental sample collection objectives, and criteria for conducting site investigation activities at Corrective Action Unit (CAU) 309, Area 12 Muckpiles, Nevada Test Site (NTS), Nevada. This CAIP has been developed in accordance with the Federal Facility Agreement and Consent Order (FFACO) (1996) that was agreed to by the State of Nevada, the U.S. Department of Energy (DOE), and the U.S. Department of Defense (DoD). Corrective Action Unit 309 is located in Area 12 of the NTS, which is approximately 65 miles (mi) northwest of Las Vegas, Nevada (Figure 1-1). Area 12 is approximately 40 mi beyond the main gate to the NTS. Corrective Action Unit 309 is comprised of the three Corrective Action Sites (CASs) shown on Figure 1-1 and listed below: CAS 12-06-09, Muckpile; CAS 12-08-02, Contaminated Waste Dump (CWD); and CAS 12-28-01, I, J, and K-Tunnel Debris. Corrective Action Sites 12-06-09 and 12-08-02 will be collectively referred to as muckpiles in this document. Corrective Action Site 12-28-01 will be referred to as the fallout plume because of the extensive lateral area of debris and fallout contamination resulting from the containment failures of the J-and K-Tunnels. The corrective action investigation (CAI) will include field inspections, radiological surveys, and media sampling, where appropriate. Data will also be obtained to support waste management decisions. The CASs in CAU 309 are being investigated because hazardous and/or radioactive constituents may be present in concentrations that could potentially pose a threat to human health and/or the environment. Existing information on the nature and extent of potential contamination at these sites are insufficient to evaluate and recommend corrective action alternatives for the CASs. Therefore, additional information will be obtained by conducting a CAI prior to evaluating corrective action

  20. Corrective Action Investigation Plan for Corrective Action Unit 370: T-4 Atmospheric Test Site, Nevada Test Site, Nevada with ROTC-1, Revision 0

    SciTech Connect

    Pat Matthews

    2008-04-01

    Corrective Action Unit (CAU) 370 is located in Area 4 of the Nevada Test Site, which is approximately 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 370 is comprised of Corrective Action Site (CAS) 04-23-01, Atmospheric Test Site T-4. This site is being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and/or implement a corrective action. Additional information will be obtained by conducting a corrective action investigation (CAI) before evaluating corrective action alternatives and selecting the appropriate corrective action for this CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document. The investigation results may also be used to evaluate improvements in the Soils Project strategy to be implemented. The site will be investigated based on the data quality objectives (DQOs) developed on December 10, 2007, by representatives of the Nevada Division of Environmental Protection; U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office; Desert Research Institute; Stoller-Navarro Joint Venture; and National Security Technologies, LLC. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 370. Appendix A provides a detailed discussion of the DQO methodology and the DQOs specific to the CAS. The scope of the CAI for CAU 370 includes the following activities: • Move surface debris and/or materials, as needed, to facilitate sampling. • Conduct radiological surveys. • Perform field screening. • Collect and submit environmental samples for laboratory analysis to determine whether contaminants of concern are present. • If contaminants of concern are present, collect samples to define the extent of the

  1. Corrective Action Investigation Plan for Corrective Action Unit 139: Waste Disposal Sites, Nevada Test Site, Nevada, Rev. No.: 0

    SciTech Connect

    Grant Evenson

    2006-04-01

    Corrective Action Unit (CAU) 139 is located in Areas 3, 4, 6, and 9 of the Nevada Test Site, which is 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 139 is comprised of the seven corrective action sites (CASs) listed below: (1) 03-35-01, Burn Pit; (2) 04-08-02, Waste Disposal Site; (3) 04-99-01, Contaminated Surface Debris; (4) 06-19-02, Waste Disposal Site/Burn Pit; (5) 06-19-03, Waste Disposal Trenches; (6) 09-23-01, Area 9 Gravel Gertie; and (7) 09-34-01, Underground Detection Station. These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives with the exception of CASs 09-23-01 and 09-34-01. Regarding these two CASs, CAS 09-23-01 is a gravel gertie where a zero-yield test was conducted with all contamination confined to below ground within the area of the structure, and CAS 09-34-01 is an underground detection station where no contaminants are present. Additional information will be obtained by conducting a corrective action investigation (CAI) before evaluating corrective action alternatives and selecting the appropriate corrective action for the other five CASs where information is insufficient. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on January 4, 2006, by representatives of the Nevada Division of Environmental Protection; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; Stoller-Navarro Joint Venture; and Bechtel Nevada. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 139.

  2. Maxi CAI with a Micro.

    ERIC Educational Resources Information Center

    Gerhold, George; And Others

    This paper describes an effective microprocessor-based CAI system which has been repeatedly tested by a large number of students and edited accordingly. Tasks not suitable for microprocessor based systems (authoring, testing, and debugging) were handled on larger multi-terminal systems. This approach requires that the CAI language used on the…

  3. Corrective Action Investigation Plan for Corrective Action Unit 551: Area 12 Muckpiles, Nevada Test Site, Nevada, Rev. No. 0

    SciTech Connect

    Robert F. Boehlecke

    2004-06-01

    This Corrective Action Investigation Plan (CAIP) contains project-specific information including facility descriptions, environmental sample collection objectives, and criteria for conducting site investigation activities at Corrective Action Unit (CAU) 551, Area 12 muckpiles, Nevada Test Site (NTS), Nevada. This CAIP has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996) that was agreed to by the State of Nevada, the U.S. Department of Energy (DOE), and the U.S. Department of Defense. Corrective Action Unit 551 is located in Area 12 of the NTS, which is approximately 110 miles (mi) northwest of Las Vegas, Nevada (Figure 1-1). Area 12 is approximately 40 miles beyond the main gate to the NTS. Corrective Action Unit 551 is comprised of the four Corrective Action Sites (CASs) shown on Figure 1-1 and listed below: (1) 12-01-09, Aboveground Storage Tank and Stain; (2) 12-06-05, Muckpile; (3) 12-06-07, Muckpile; and (4) 12-06-08, Muckpile. Corrective Action Site 12-01-09 is located in Area 12 and consists of an above ground storage tank (AST) and associated stain. Corrective Action Site 12-06-05 is located in Area 12 and consists of a muckpile associated with the U12 B-Tunnel. Corrective Action Site 12-06-07 is located in Area 12 and consists of a muckpile associated with the U12 C-, D-, and F-Tunnels. Corrective Action Site 12-06-08 is located in Area 12 and consists of a muckpile associated with the U12 B-Tunnel. In keeping with common convention, the U12B-, C-, D-, and F-Tunnels will be referred to as the B-, C-, D-, and F-Tunnels. The corrective action investigation (CAI) will include field inspections, radiological surveys, and sampling of media, where appropriate. Data will also be obtained to support waste management decisions.

  4. Corrective Action Investigation Plan for Corrective Action Unit 551: Area 12 Muckpiles, Nevada Test Site, Nevada, Rev. No.: 0

    SciTech Connect

    David A. Strand

    2004-06-01

    This Corrective Action Investigation Plan (CAIP) contains project-specific information including facility descriptions, environmental sample collection objectives, and criteria for conducting site investigation activities at Corrective Action Unit (CAU) 551, Area 12 muckpiles, Nevada Test Site (NTS), Nevada. This CAIP has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996) that was agreed to by the State of Nevada, the U.S. Department of Energy (DOE), and the U.S. Department of Defense. Corrective Action Unit 551 is located in Area 12 of the NTS, which is approximately 110 miles (mi) northwest of Las Vegas, Nevada (Figure 1-1). Area 12 is approximately 40 miles beyond the main gate to the NTS. Corrective Action Unit 551 is comprised of the four Corrective Action Sites (CASs) shown on Figure 1-1 and listed below: (1) 12-01-09, Aboveground Storage Tank and Stain; (2) 12-06-05, Muckpile; (3) 12-06-07, Muckpile; and (4) 12-06-08, Muckpile. Corrective Action Site 12-01-09 is located in Area 12 and consists of an above ground storage tank (AST) and associated stain. Corrective Action Site 12-06-05 is located in Area 12 and consists of a muckpile associated with the U12 B-Tunnel. Corrective Action Site 12-06-07 is located in Area 12 and consists of a muckpile associated with the U12 C-, D-, and F-Tunnels. Corrective Action Site 12-06-08 is located in Area 12 and consists of a muckpile associated with the U12 B-Tunnel. In keeping with common convention, the U12B-, C-, D-, and F-Tunnels will be referred to as the B-, C-, D-, and F-Tunnels. The corrective action investigation (CAI) will include field inspections, radiological surveys, and sampling of media, where appropriate. Data will also be obtained to support waste management decisions.

  5. Corrective Action Investigation Plan for Corrective Action Unit 552: Area 12 Muckpile and Ponds, Nevada Test Site, Nevada, Rev. No.: 1 with ROTC 1 and 2

    SciTech Connect

    David A. Strand

    2005-01-01

    This Corrective Action Investigation Plan (CAIP) contains project-specific information including facility descriptions, environmental sample collection objectives, and criteria for conducting site investigation activities at Corrective Action Unit (CAU) 552: Area 12 Muckpile and Ponds, Nevada Test Site (NTS), Nevada. This CAIP has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996) that was agreed to by the State of Nevada, the U.S. Department of Energy (DOE), and the U.S. Department of Defense. The NTS is approximately 65 miles (mi) northwest of Las Vegas, Nevada (Figure 1-1). Corrective Action Unit 552 is comprised of the one Corrective Action Site which is 12-23-05, Ponds. One additional CAS, 12-06-04, Muckpile (G-Tunnel Muckpile), was removed from this CAU when it was determined that the muckpile is an active site. A modification to the FFACO to remove CAS 12-06-04 was approved by the Nevada Division of Environmental Protection (NDEP) on December 16, 2004. The G-Tunnel ponds were first identified in the 1991 Reynolds Electrical & Engineering Co., Inc. document entitled, ''Nevada Test Site Inventory of Inactive and Abandoned Facilities and Waste Sites'' (REECo, 1991). Corrective Action Unit 552 is being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Therefore, additional information will be obtained by conducting a corrective action investigation (CAI) prior to evaluating and selecting the corrective action alternatives for the site. The CAI will include field inspections, radiological surveys, and sampling of appropriate media. Data will also be obtained to support investigation-derived waste (IDW) disposal and potential future waste management decisions.

  6. Corrective Action Investigation Plan for Corrective Action Unit 372: Area 20 Cabriolet/Palanquin Unit Craters Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews

    2009-06-01

    Corrective Action Unit (CAU) 372 is located in Areas 18 and 20 of the Nevada Test Site, which is approximately 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 372 is comprised of the four corrective action sites (CASs) listed below: • 18-45-02, Little Feller I Surface Crater • 18-45-03, Little Feller II Surface Crater • 20-23-01, U-20k Contamination Area • 20-45-01, U-20L Crater (Cabriolet) These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation (CAI) before evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on February 10, 2009, by representatives of the Nevada Division of Environmental Protection; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; Stoller-Navarro Joint Venture; Desert Research Institute, and National Security Technologies, LLC. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 372.

  7. Corrective Action Investigation Plan for Corrective Action Unit 536: Area 3 Release Site, Nevada Test Site, Nevada (Rev. 0 / June 2003), Including Record of Technical Change No. 1

    SciTech Connect

    2003-06-27

    This Corrective Action Investigation Plan contains the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office's approach to collect the data necessary to evaluate corrective action alternatives (CAAs) appropriate for the closure of Corrective Action Unit (CAU) 536: Area 3 Release Site, Nevada Test Site, Nevada, under the Federal Facility Agreement and Consent Order. Corrective Action Unit 536 consists of a single Corrective Action Site (CAS): 03-44-02, Steam Jenny Discharge. The CAU 536 site is being investigated because existing information on the nature and extent of possible contamination is insufficient to evaluate and recommend corrective action alternatives for CAS 03-44-02. The additional information will be obtained by conducting a corrective action investigation (CAI) prior to evaluating CAAs and selecting the appropriate corrective action for this CAS. The results of this field investigation are to be used to support a defensible evaluation of corrective action alternatives in the corrective action decision document. Record of Technical Change No. 1 is dated 3-2004.

  8. Corrective Action Investigation Plan for Corrective Action Unit 224: Decon Pad and Septic Systems Nevada Test Site, Nevada, Rev. No.: 0, with ROTC 1 and 2

    SciTech Connect

    David A. Strand

    2004-04-01

    This Corrective Action Investigation Plan (CAIP) contains project-specific information including facility descriptions, environmental sample collection objectives, and criteria for conducting site investigation activities at Corrective Action Unit (CAU) 224: Decon Pad and Septic Systems, Nevada Test Site (NTS), Nevada. This CAIP has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996) that was agreed to by the State of Nevada, the U.S. Department of Energy (DOE), and the U.S. Department of Defense (DoD). The NTS is approximately 65 miles (mi) northwest of Las Vegas, Nevada (Figure 1-1). Corrective Action Unit 224 is comprised of the nine Corrective Action Sites (CASs) listed below: 02-04-01, Septic Tank (Buried); 03-05-01, Leachfield; 05-04-01, Septic Tanks (4)/Discharge Area; 06-03-01, Sewage Lagoons (3); 06-05-01, Leachfield; 06-17-04, Decon Pad and Wastewater Catch; 06-23-01, Decon Pad Discharge Piping; 11-04-01, Sewage Lagoon; and 23-05-02, Leachfield. Corrective Action Sites 06-05-01, 06-23-01, and 23-05-02 were identified in the 1991 Reynolds Electrical & Engineering Co., Inc. (REECo) inventory (1991). The remaining sites were identified during review of various historical documents. Additional information will be obtained by conducting a corrective action investigation (CAI) prior to evaluating and selecting a corrective action alternative for each CAS. The CAI will include field inspections, radiological and geological surveys, and sample collection. Data will also be obtained to support investigation-derived waste (IDW) disposal and potential future waste management decisions.

  9. Corrective Action Investigation Plan for Corrective Action Unit 552: Area 12 Muckpile and Ponds, Nevada Test Site, Nevada, Rev. 1

    SciTech Connect

    Robert F. Boehlecke

    2005-01-01

    Corrective Action Unit 552 is being investigated because man-made radionuclides and chemical contaminants may be present in concentrations that could potentially pose an unacceptable risk to human health and/or the environment. The CAI will be conducted following the data quality objectives (DQOs) developed by representatives of the Nevada Division of Environmental Protection (NDEP) and the DOE National Nuclear Security Administration Nevada Site Office (NNSA/NSO). The DQOs are used to identify the type, amount, and quality of data needed to define the nature and extent of contamination and identify and evaluate the most appropriate corrective action alternatives for CAU 552. The primary problem statement for the investigation is: ''Existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives for CAS 12-23-05.'' To address this problem statement, the resolution of the following two decision statements is required: (1) The Decision I statement is: ''Is a contaminant present within the CAU at a concentration that could pose an unacceptable risk to human health and the environment?'' Any site-related contaminant detected at a concentration exceeding the corresponding preliminary action level (PAL), as defined in Section A.1.4.2, will be considered a contaminant of concern (COC). A COC is defined as a site-related constituent that exceeds the screening criteria (PAL). The presence of a contaminant within each CAS is defined as the analytical detection of a COC. (2) The Decision II statement is: ''Determine the extent of contamination identified above PALs.'' This decision will be achieved by the collection of data that are adequate to define the extent of COCs. Decision II samples are used to determine the lateral and vertical extent of the contamination as well as the likelihood of COCs to migrate outside of the site boundaries. The migration pattern can be derived from the Decision

  10. Corrective Action Investigation Plan for Corrective Action Unit 166: Storage Yards and Contaminated Materials, Nevada Test Site, Nevada, Rev. No.: 0

    SciTech Connect

    David Strand

    2006-06-01

    Corrective Action Unit 166 is located in Areas 2, 3, 5, and 18 of the Nevada Test Site, which is 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit (CAU) 166 is comprised of the seven Corrective Action Sites (CASs) listed below: (1) 02-42-01, Cond. Release Storage Yd - North; (2) 02-42-02, Cond. Release Storage Yd - South; (3) 02-99-10, D-38 Storage Area; (4) 03-42-01, Conditional Release Storage Yard; (5) 05-19-02, Contaminated Soil and Drum; (6) 18-01-01, Aboveground Storage Tank; and (7) 18-99-03, Wax Piles/Oil Stain. These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation (CAI) before evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on February 28, 2006, by representatives of the Nevada Division of Environmental Protection; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; Stoller-Navarro Joint Venture; and Bechtel Nevada. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 166. Appendix A provides a detailed discussion of the DQO methodology and the DQOs specific to each CAS. The scope of the CAI for CAU 166 includes the following activities: (1) Move surface debris and/or materials, as needed, to facilitate sampling. (2) Conduct radiological surveys. (3) Perform field screening. (4) Collect and submit environmental samples for laboratory analysis to determine if

  11. Corrective Action Investigation Plan for Corrective Action Unit 234: Mud Pits, Cellars, and Mud Spills, Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Grant Evenson

    2007-08-01

    Corrective Action Unit 234, Mud Pits, Cellars, and Mud Spills, consists of 12 inactive sites located in the north and northeast section of the NTS. The 12 CAU 234 sites consist of mud pits, mud spills, mud sumps, and an open post-test cellar. The CAU 234 sites were all used to support nuclear testing conducted in the Yucca Flat and Rainier Mesa areas during the 1950s through the 1970s. The CASs in CAU 234 are being investigated because hazardous and/or radioactive constituents may be present in concentrations that could potentially pose a threat to human health and the environment. Existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives for the CASs. Additional information will be generated by conducting a CAI before evaluating and selecting appropriate corrective action alternatives.

  12. Zr Isotope Systematics of Allende CAIs

    NASA Astrophysics Data System (ADS)

    Mane, P.; Romaniello, S. J.; Brennecka, G. A.; Williams, C. D.; Wadhwa, M.

    2014-09-01

    We report high precision Zr isotopic measurements of CAIs from Allende CV3 meteorite. Our results indicate a uniform Zr isotopic composition in the CAI forming region, with enrichment in r-process isotope 96Zr.

  13. Teacher's Handbook for CAI Courses.

    ERIC Educational Resources Information Center

    Suppes, Patrick; And Others

    The handbooks for the most widely used computer-assisted instruction (CAI) courses now available on computer terminals at the Institute for Mathematical Studies in the Social Sciences at Stanford University are presented. Handbooks are included for the following courses: Strands Drill-and-practice (arithmetic fundamentals for fourth grade), Logic…

  14. Corrective Action Investigation Plan for Corrective Action Unit 543: Liquid Disposal Units Nevada Test Site, Nevada, Rev. No.: 0 with ROTC 1 and 2

    SciTech Connect

    David A. Strand

    2004-05-01

    This Corrective Action Investigation Plan (CAIP) contains project-specific information including facility descriptions, environmental sample collection objectives, and criteria for conducting site investigation activities at Corrective Action Unit (CAU) 543: Liquid Disposal Units, Nevada Test Site (NTS), Nevada. This CAIP has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996) that was agreed to by the State of Nevada, the U.S. Department of Energy (DOE), and the U.S Department of Defense (DoD). Corrective Action Unit 543 is located in Area 6 and Area 15 of the NTS, which is approximately 65 miles (mi) northwest of Las Vegas, Nevada (Figure 1-1). Seven corrective action sites (CASs) comprise CAU 543 and are listed below: (1) 06-07-01, Decon Pad; (2) 15-01-03, Aboveground Storage Tank; (3) 15-04-01, Septic Tank; (4) 15-05-01, Leachfield; (5) 15-08-01, Liquid Manure Tank; (6) 15-23-01, Underground Radioactive Material Area; and (7) 15-23-03, Contaminated Sump, Piping. Corrective Action Site 06-07-01, Decon Pad, is located in Area 6 and consists of the Area 6 Decontamination Facility and its components that are associated with decontamination of equipment, vehicles, and materials related to nuclear testing. The six CASs in Area 15 are located at the U.S. Environmental Protection Agency (EPA) Farm and are related to waste disposal activities at the EPA Farm. The EPA Farm was a fully-functional dairy associated with animal experiments conducted at the on-site laboratory. The corrective action investigation (CAI) will include field inspections, video-mole surveys, and sampling of media, where appropriate. Data will also be obtained to support waste management decisions. The CASs within CAU 543 are being investigated because hazardous and/or radioactive constituents may be present at concentrations that could potentially pose a threat to human health and the environment. The seven CASs in CAU 543 primarily consist of

  15. Effects of Computer Assisted Instruction (CAI) on Secondary School Students' Performance in Biology

    ERIC Educational Resources Information Center

    Yusuf, Mudasiru Olalere; Afolabi, Adedeji Olufemi

    2010-01-01

    This study investigated the effects of computer assisted instruction (CAI) on secondary school students' performance in biology. Also, the influence of gender on the performance of students exposed to CAI in individualised or cooperative learning settings package was examined. The research was a quasi experimental involving a 3 x 2 factorial…

  16. Corrective Action Investigation Plan for Corrective Action Unit 542: Disposal Holes, Nevada Test Site, Nevada, Rev. No.: 0

    SciTech Connect

    Laura Pastor

    2006-05-01

    Corrective Action Unit (CAU) 542 is located in Areas 3, 8, 9, and 20 of the Nevada Test Site, which is 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 542 is comprised of eight corrective action sites (CASs): (1) 03-20-07, ''UD-3a Disposal Hole''; (2) 03-20-09, ''UD-3b Disposal Hole''; (3) 03-20-10, ''UD-3c Disposal Hole''; (4) 03-20-11, ''UD-3d Disposal Hole''; (5) 06-20-03, ''UD-6 and UD-6s Disposal Holes''; (6) 08-20-01, ''U-8d PS No.1A Injection Well Surface Release''; (7) 09-20-03, ''U-9itsy30 PS No.1A Injection Well Surface Release''; and (8) 20-20-02, ''U-20av PS No.1A Injection Well Surface Release''. These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation before evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on January 30, 2006, by representatives of the Nevada Division of Environmental Protection; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; Stoller-Navarro Joint Venture; and Bechtel Nevada. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 542. Appendix A provides a detailed discussion of the DQO methodology and the DQOs specific to each CAS. The scope of the CAI for CAU 542 includes the following activities: (1) Move surface debris and/or materials, as needed, to facilitate sampling. (2) Conduct radiological surveys. (3) Conduct geophysical surveys to

  17. Corrective Action Investigation Plan for Corrective Action Unit 97: Yucca Flat/Climax Mine, Nevada National Security Site, Nevada with ROTCs 1, 2, and 3 (Revision 0, September 2000)

    SciTech Connect

    Andrews, Robert; Marutzky, Sam

    2000-09-01

    This Corrective Action Investigation Plan contains the U.S. Department of Energy, Nevada Operations Office's (DOE/NV's) approach to collect the data necessary to evaluate Corrective Action Alternatives (CAAs) appropriate for the closure of Corrective Action Unit (CAU) 97 under the Federal Facility Agreement and Consent Order (FFACO). Corrective Action Unit 97, collectively known as the Yucca Flat/Climax Mine CAU, consists of 720 Corrective Action Sites (CASs). The Yucca Flat/Climax Mine CAU extends over several areas of the NTS and constitutes one of several areas used for underground nuclear testing in the past. The nuclear tests resulted in groundwater contamination in the vicinity as well as downgradient of the underground test areas. Based on site history, the Yucca Flat underground nuclear tests were conducted in alluvial, volcanic, and carbonate rocks; whereas, the Climax Mine tests were conducted in an igneous intrusion located in northern Yucca Flat. Particle-tracking simulations performed during the regional evaluation indicate that the local Climax Mine groundwater flow system merges into the much larger Yucca Flat groundwater flow systems during the 1,000-year time period of interest. Addressing these two areas jointly and simultaneously investigating them as a combined CAU has been determined the best way to proceed with corrective action investigation (CAI) activities. The purpose and scope of the CAI includes characterization activities and model development conducted in five major sequential steps designed to be consistent with FFACO Underground Test Area Project's strategy to predict the location of the contaminant boundary, develop and implement a corrective action, and close each CAU. The results of this field investigation will support a defensible evaluation of CAAs in the subsequent corrective action decision document.

  18. The Screen Display Syntax for CAI.

    ERIC Educational Resources Information Center

    Richards, Boyd F.; Salisbury, David F.

    1987-01-01

    Describes four storyboard techniques frequently used in designing computer assisted instruction (CAI) programs, and explains screen display syntax (SDS), a new technique combining the major advantages of the storyboard techniques. SDS was developed to facilitate communication among designers, programmers, and editors working on a large CAI basic…

  19. Implications of Windowing Techniques for CAI.

    ERIC Educational Resources Information Center

    Heines, Jesse M.; Grinstein, Georges G.

    This paper discusses the use of a technique called windowing in computer assisted instruction to allow independent control of functional areas in complex CAI displays and simultaneous display of output from a running computer program and coordinated instructional material. Two obstacles to widespread use of CAI in computer science courses are…

  20. CAI: Its Cost and Its Role.

    ERIC Educational Resources Information Center

    Pressman, Israel; Rosenbloom, Bruce

    1984-01-01

    Describes and evaluates costs of hardware, software, training, and maintenance for computer assisted instruction (CAI) as they relate to total system cost. An example of an educational system provides an illustration of CAI cost analysis. Future developments, cost effectiveness, affordability, and applications in public and private environments…

  1. The Evolutionary Development of CAI Hardware.

    ERIC Educational Resources Information Center

    Stifle, John E.

    After six years of research in computer assisted instruction (CAI) using PLATO III, a decision was made at the University of Illinois to develop a larger system as a national CAI resource. This document describes the design specifications and problems in the development of PLATO IV, a system which is capable of accomodating up to 4,000 terminals…

  2. Economic Evaluation of CAI in Special Education.

    ERIC Educational Resources Information Center

    Wilkinson, Gene L.

    This is an introductory presentation of economic evaluation methods for assessing computer-assisted instruction (CAI). Six different costing techniques, including cost effectiveness, are reviewed. Cost effectiveness is then examined in terms of its usefulness for evaluating CAI. A simplified system for cost effectiveness evaluation is presented…

  3. Computers for Your Classroom: CAI and CMI.

    ERIC Educational Resources Information Center

    Thomas, David B.; Bozeman, William C.

    1981-01-01

    The availability of compact, low-cost computer systems provides a means of assisting classroom teachers in the performance of their duties. Computer-assisted instruction (CAI) and computer-managed instruction (CMI) are two applications of computer technology with which school administrators should become familiar. CAI is a teaching medium in which…

  4. 14 CFR 13.129 - Post-investigation action.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Post-investigation action. 13.129 Section 13.129 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL... Investigation § 13.129 Post-investigation action. A decision on whether to initiate subsequent action shall...

  5. 14 CFR 13.129 - Post-investigation action.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Post-investigation action. 13.129 Section 13.129 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL... Investigation § 13.129 Post-investigation action. A decision on whether to initiate subsequent action shall...

  6. 14 CFR 13.129 - Post-investigation action.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Post-investigation action. 13.129 Section 13.129 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL... Investigation § 13.129 Post-investigation action. A decision on whether to initiate subsequent action shall...

  7. A unified framework for producing CAI melting, Wark-Lovering rims and bowl-shaped CAIs

    NASA Astrophysics Data System (ADS)

    Liffman, Kurt; Cuello, Nicolas; Paterson, David A.

    2016-10-01

    Calcium-Aluminium inclusions (CAIs) formed in the Solar system, some 4567 million years ago. CAIs are almost always surrounded by Wark-Lovering rims (WLRs), which are a sequence of thin, mono/bi-mineralic layers of refractory minerals, with a total thickness in the range of 1-100 microns. Recently, some CAIs have been found that have tektite-like bowl-shapes. To form such shapes, the CAI must have travelled through a rarefied gas at hypersonic speeds. We show how CAIs may have been ejected from the inner solar accretion disc via the centrifugal interaction between the solar magnetosphere and the inner disc rim. They subsequently punched through the hot, inner disc rim wall at hypersonic speeds. This re-entry heating partially or completely evaporated the CAIs. Such evaporation could have significantly increased the metal abundances of the inner disc rim. High speed movement through the inner disc produced WLRs. To match the observed thickness of WLRs required metal abundances at the inner disc wall that are of order 10 times that of standard solar abundances. The CAIs cooled as they moved away from the protosun, the deduced CAI cooling rates are consistent with the CAI cooling rates obtained from experiment and observation. The speeds and gas densities required to form bowl-shaped CAIs are also consistent with the expected speeds and gas densities for larger, ˜1 cm, CAIs punching through an inner accretion disc wall.

  8. CAIS. Condition Assessment Information System

    SciTech Connect

    Oak, J.C.

    1996-09-30

    CAIS is used by Architects and Engineers to gather facility condition assessment data. This data consist of architectural, civil, structural, electrical, and mechanical systems and components that are a part of the inspected facility. Data is collected using a hand-held, pen-based computer system which is preprogrammed for detailed inventories of individual components. The program is deficiency based for collecting data for repair and replacement observations. Observations are recorded on checklists preformatted to individual site needs, allowing for comments on unusual conditions to be documented on site. Data is transferred to a central database, where it can be reviewed, costed, and reported on using different scenarios. Information can be transferred to the DOE operations offices as well as to the DOE FIMS database for each site.

  9. Corrective Action Investigation Plan for Corrective Action Unit 367: Area 10 Sedan, Ess and Uncle Unit Craters Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews

    2009-12-01

    Corrective Action Unit 367 is located in Area 10 of the Nevada Test Site, which is approximately 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 367 comprises the four corrective action sites (CASs) listed below: • 10-45-01, U-10h Crater (Sedan) • 10-45-02, Ess Crater Site • 10-09-03, Mud Pit • 10-45-03, Uncle Crater Site The CASs in CAU 367 are being investigated because hazardous and/or radioactive contaminants may be present in concentrations that exceed risk-based corrective action (RBCA) levels. Existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend CAAs for the CASs. Additional information will be generated by conducting a CAI before evaluating and selecting CAAs. The scope of the corrective action investigation for CAU 367 includes the following activities: • Move surface debris and/or materials, as needed, to facilitate sampling. • Conduct radiological surveys. • Collect and submit environmental samples for laboratory analysis to determine the area where TED at the site exceeds FALs (i.e., corrective action boundary). • Evaluate TED to potential receptors in areas along Mercury Highway that have been impacted by a release of radionuclides from the Sedan test. • Collect and submit environmental samples for laboratory analysis related to the drilling mud within CAS 10-09-03, Mud Pit, and any encountered stains or waste as necessary to determine whether COCs are present. • If COCs are present, collect additional step-out samples to define the extent of the contamination. • Collect samples of investigation-derived waste, as needed, for waste management purposes.

  10. The Interplay between Different Forms of CAI and Students' Preferences of Learning Environment in the Secondary Science Class

    ERIC Educational Resources Information Center

    Chang, Chun-Yen; Tsai, Chin-Chung

    2005-01-01

    This evaluation study investigated the effects of a teacher-centered versus student-centered computer-assisted instruction (CAI) on 10th graders' earth science student learning outcomes. This study also explored whether the effects of different forms of computer-assisted instruction (CAI) on student learning outcomes were influenced by student…

  11. Corrective Action Investigation Plan for Corrective Action Unit 99: Rainier Mesa/Shoshone Mountain, Nevada Test Site, Nevada with Errata and ROTC 1, Rev. No. 0

    SciTech Connect

    McCord, John; Marutzky, Sam

    2004-12-01

    caldera as well as from more distant sources. This has resulted in a layered volcanic stratigraphy composed of thick deposits of welded and nonwelded ash-flow tuff and lava flows. These deposits are proximal to the source caldera and are interstratified with the more distal facies of fallout tephra and bedded reworked tuff from more distant sources. In each area, a similar volcanic sequence was deposited upon Paleozoic carbonate and siliciclastic rocks that are disrupted by various thrust faults, normal faults, and strike-slip faults. In both Rainier Mesa (km) to the southwest, and Tippipah Spring, 4 km to the north, and the tunnel complex is dry. Particle-tracking simulations performed during the value of information analysis (VOIA) (SNJV, 2004b) indicate that most of the regional groundwater that underlies the test locations at Rainier Mesa and Shoshone Mountain eventually follows similar and parallel paths and ultimately discharges in Death Valley and the Amargosa Desert. Particle-tracking simulations conducted for the regional groundwater flow and risk assessment indicated that contamination from Rainier Mesa and Shoshone Mountain were unlikely to leave the NTS during the 1,000-year period of interest (DOE/NV, 1997a). It is anticipated that CAU-scale modeling will modify these results somewhat, but it is not expected to radically alter the outcome of these previous particle-tracking simulations within the 1,000-year period of interest. The Rainier Mesa/Shoshone Mountain CAIP describes the corrective action investigation (CAI) to be conducted at the Rainier Mesa/Shoshone Mountain CAU to evaluate the extent of contamination in groundwater due to the underground nuclear testing. The CAI will be conducted by the UGTA Project, which is part of the NNSA/NSO Environmental Restoration Project (ERP). The purpose and scope of the CAI are presented in this section, followed by a summary of the entire document.

  12. Investigating and Evaluating Environmental Issues and Actions: Skill Development Modules.

    ERIC Educational Resources Information Center

    Hungerford, Harold R.; And Others

    Middle school and high school students need to develop many skills in order to investigate environmental issues and know the basics of citizenship action strategies. This student guide is designed to teach students how to investigate and evaluate environmental issues and actions. The guide is presented in six modules. Module 1 introduces the…

  13. CAIs in CO3 Meteorites: Parent Body or Nebular Alteration?

    NASA Astrophysics Data System (ADS)

    Greenwood, R. C.; Hutchison, R.; Huss, G. R.; Hutcheon, I. D.

    1992-07-01

    It is widely held that alteration of Ca Al-rich inclusions (CAIs) in CV3 and CO3 meteorites occurred in the nebula (Hashimoto 1992). The CO3 chondrites, however, appear to define a metamorphic sequence dominated by parent body, and not nebular, metamorphic effects (Scott and Jones, 1990). To investigate the effects of metamorphism on CAIs we have studied inclusions from 4 CO chondrites: Colony (3.0), Felix (3.2), Lance (3.4), and Warrenton (3.6). In a section of Colony (74 mm^2) 81 CAIs, 30-870 micrometers long, comprise 52 nodular spinel-rich inclusions (fragments of Type-A CAI composed largely of spinel), 12 spinel-pyroxene inclusions, 10 melilite-rich inclusions, 2 hibonite-only inclusions, 2 CaAl4O7-bearing inclusions, and 3 spinel-pyroxene- olivine inclusions. Although a find, CAIs in Colony are relatively fresh, melilite in particular being little altered. In 79% of the spinel-bearing inclusions, spinel has <2wt% FeO, which otherwise ranges to 34.8%. Mg isotopic compositions were determined in 5 selected Colony inclusion; evidence of ^26Mg* from decay of ^26Al was found in 4 CAI. A hibonite-only inclusion has the largest ^26Mg* excess, delta^26Mg 32o/oo. Data show no evidence of isotopic disturbance and define a linear array with slope ^26Mg* /^27Al = (3.4+- 0.6) x 10^-5, like that obtained by Davis and Hinton (1986) in a hibonite-bearing spherule from Ornans. Despite Al/Mg ratios of up to 1500, CaAl4O7 in one inclusion shows no evidence of ^26Mg*; ^26Mg* < 4 x 10^-6. All three melilite-bearing inclusions from Colony C21 (angstrom k(sub)8.3-14.3), C56 (angstrom k(sub)10.5-16) and C62 (angstrom k(sub)15-21) show evidence of radiogenic ^26Mg*. Excess ^26Mg positively correlates with the Al/Mg ratios but the data do not define a unique initial value of ^26Al/^27Al. Data for melilite in C21, in particular, show evidence for disturbance of the Al-Mg system, as is common for Allende CAI (Podosek et al. 1991). Melilites in C56 in contrast show no evidence of

  14. CAIs in Semarkona (LL3.0)

    NASA Technical Reports Server (NTRS)

    Mishra, R. K.; Simon, J. I.; Ross, D. K.; Marhas, K. K.

    2016-01-01

    Calcium, Aluminum-rich inclusions (CAIs) are the first forming solids of the Solar system. Their observed abundance, mean size, and mineralogy vary quite significantly between different groups of chondrites. These differences may reflect the dynamics and distinct cosmochemical conditions present in the region(s) of the protoplanetary disk from which each type likely accreted. Only about 11 such objects have been found in L and LL type while another 57 have been found in H type ordinary chondrites, compared to thousands in carbonaceous chondrites. At issue is whether the rare CAIs contained in ordinary chondrites truly reflect a distinct population from the inclusions commonly found in other chondrite types. Semarkona (LL3.00) (fall, 691 g) is the most pristine chondrite available in our meteorite collection. Here we report petrography and mineralogy of 3 CAIs from Semarkona

  15. Effects of Computer-assisted Instruction (CAI) on 11th Graders' Attitudes to Biology and CAI and Understanding of Reproduction in Plants and Animals

    NASA Astrophysics Data System (ADS)

    Soyibo, Kola; Hudson, Ann

    2000-02-01

    This study investigated whether the use of the combination of the lecture, discussion and computer-assisted instruction (CAI) significantly improved the experimental students' attitudes to biology and the computer/CAI and their understanding of reproduction in plants and animals. The sample comprised 77 Jamaican grade 11 female students from two traditional high schools in Kingston. Attitudes to a biology questionnaire, attitudes to the computer/CAI questionnaire and a biology achievement test (BAT) were used for data collection. The results indicated that the experimental subjects' post-test attitudes to biology and the computer/CAI were significantly better than those of the control group subjects taught with the lecture and discussion methods; the experimental subjects significantly outscored the control group subjects on the post-test BAT; there were significant differences in their post-test BAT means based on their attitudes to biology in favour of experimental subjects with highly favourable attitudes to biology, but there were no significant differences in their means attributable to their post-test attitudes to the computer/CAI; there was a positive statistically significant but weak relationship between the experimental subjects' post-test attitudes to biology and their post-test BAT scores.

  16. CAI in Music Theory: Paradigms: Potential: Problems.

    ERIC Educational Resources Information Center

    Hultberg, W. Earle; Hultberg, Mary Lou

    Computer-assisted instructional programs have been developed at the State University College at Potsdam, New York, to teach basic concepts of music theory. The Computer-based Learning Experiences in Music Fundamentals (CLEF) project has spawned computer assisted instruction (CAI) programs which use an IBM 360/30 configuration with 2741 terminals…

  17. Individual Differences in Learner Controlled CAI.

    ERIC Educational Resources Information Center

    Judd, Wilson A.; And Others

    Two assumptions in support of learner-controlled computer-assisted instruction (CAI) are that (1) instruction administered under learner control will be less aversive than if administered under program control, and (2) the student is sufficiently aware of his learning state to make, in most instances, his own instructional decisions. Some 130…

  18. The Evolutionary Development of CAI Evaluation Approaches.

    ERIC Educational Resources Information Center

    Avner, R. A.

    The role of evaluation in the development of evolutionary procedures is briefly described and highlighted. Four aspects of evaluation technique which distinguish efficient from inefficient CAI programs are identified. Evaluation of products is also characterized. Findings of a continuing survey of students via questionnaire as to the value of…

  19. The Relevance of AI Research to CAI.

    ERIC Educational Resources Information Center

    Kearsley, Greg P.

    This article provides a tutorial introduction to Artificial Intelligence (AI) research for those involved in Computer Assisted Instruction (CAI). The general theme is that much of the current work in AI, particularly in the areas of natural language understanding systems, rule induction, programming languages, and socratic systems, has important…

  20. Man-Computer Communications and CAI.

    ERIC Educational Resources Information Center

    Hunka, S.

    A variety of direct and indirect instructional activities during the last ten years have employed computers. Within Computer Assisted Instruction (CAI) programs, the following broad classes of instructional strategies have been generally accepted: tutorial, drill and practice, review, testing, remediation and diagnosis, problem solving, and…

  1. The Evolutionary Development of CAI Courseware.

    ERIC Educational Resources Information Center

    Steinberg, Esther R.

    The history of computer-assisted instruction (CAI) courseware is described with specific reference to the PLATO system. Among the goals of courseware authors are finding better ways to develop the cognitive skills of students, to shift some of the burden of routine classroom instruction away from the teacher so that more class time can be spent in…

  2. Corrective action investigation plan: Cactus Spring Waste Trenches. Revision 2

    SciTech Connect

    1997-02-01

    This Correction Action Investigation Plan (CAIP) contains environmental sample collection objectives and logic for the CAU No. 426, which includes the Cactus Spring Waste Trenches, CAS No. RG-08-001-RG-CS. The Cactus Spring Waste Trenches are located at the Tonopah Test Range (TTR) which is part of the Nellis Air Force Range, approximately 255 kilometers (km) (140 miles [mi]) northwest of Las Vegas, Nevada, by air. The purpose of this investigation is to generate sufficient data to establish the types of waste buried in the trenches, identify the presence and nature of contamination, determine the vertical extent of contaminant migration below the Cactus Spring Waste Trenches, and determine the appropriate course of action for the site. The potential courses of action for the site are clean closure, closure in place (with or without remediation), or no further action.

  3. Effects of Computer-Assisted Instruction (CAI) on 11th Graders' Attitudes to Biology and CAI and Understanding of Reproduction in Plants and Animals.

    ERIC Educational Resources Information Center

    Soyibo, Kola; Hudson, Ann

    2000-01-01

    Investigates whether the use of the combination of lecture, discussion, and computer-assisted instruction (CAI) significantly improved students' attitudes toward biology and their understanding of reproduction in plants and animals. Studies grade 11 Jamaican female students (n=77) from two traditional high schools in Kingston. (Contains 19…

  4. Change in Action: Navigating and Investigating the Classroom Using Action Research.

    ERIC Educational Resources Information Center

    Tonack, De, Ed.; Dean, Ceri, Ed.

    Thirty-five Nebraska educators from across the state came together for five Saturday seminars during the 1995-96 school year to collaborate as they conducted classroom investigations. They earned 3 hours of tuition-free graduate credit. Action research was the tool for their investigations, guided by R. Sagor's book "How To Conduct Collaborative…

  5. Corrective action investigation plan: Cactus Spring Waste Trenches. Revision 2

    SciTech Connect

    1997-02-01

    This Correction Action Investigation Plan (CAIP) contains environmental sample collection objectives and logic for the Corrective Action Unit No. 426, which includes the Cactus Spring Waste Trenches, located at the Tonopah Test Range. The purpose of this investigation is to generate sufficient data to establish the types of waste buried in the trenches, identify the presence and nature of contamination, determine the vertical extent of contaminant migration below the Cactus Spring Waste Trenches, and determine the appropriate course of action for the site. The potential courses of action for the site are clean closure, closure in place (with or without remediation), or no further action. The scope of this investigation will include drilling and collecting subsurface samples from within and below the trenches. Sampling locations will be biased toward the areas most likely to be contaminated. The Cactus Spring Waste Trenches Site is identified as one of three potential locations for buried, radioactively contaminated materials from the Double Tracks Test. This test was the first of four storage-transportation tests conducted in 1963 as part of Operation Roller Coaster. The experiment involved the use of live animals to assess the inhalation intake of a plutonium aerosol.

  6. Germination of white radish, buckwheat and qing-geng-cai under low pressure in closed environment.

    PubMed

    Hinokuchi, Tsutomu; Oshima, Satoshi; Hashimoto, Hirofumi

    2004-11-01

    In order to cultivate plants under low pressure in closed environment, the germination rate of seeds of white radish was investigated under low pressure, low oxygen partial pressure and condition of pure oxygen. The result of these experiments showed that the germination rate was affected by the oxygen partial pressure. From this fact, it is possible to lower the total pressure by using only the pure oxygen in germination. Furthermore, the germination rates of seeds of buckwheat and qing-geng-cai were also investigated in pure oxygen for the comparison. Consequently, though tendency in germination rate of white radish was similar to qing-geng-cai, it was different from buckwheat.

  7. Using Action Research to Investigate Social Networking Technologies

    ERIC Educational Resources Information Center

    Worrall, Lisa; Harris, Katy

    2013-01-01

    This article outlines the first cycle of an Action Research (AR) investigation into why professional learners are not using the Social Networking Technologies (SNTs) of their bespoke website. It presents the rationale of how this study came about, the ontological and epistemological stance of the authors and how this led to the particular choice…

  8. NALDA (Naval Aviation Logistics Data Analysis) CAI (computer aided instruction)

    SciTech Connect

    Handler, B.H. ); France, P.A.; Frey, S.C.; Gaubas, N.F.; Hyland, K.J.; Lindsey, A.M.; Manley, D.O. ); Hunnum, W.H. ); Smith, D.L. )

    1990-07-01

    Data Systems Engineering Organization (DSEO) personnel developed a prototype computer aided instruction CAI system for the Naval Aviation Logistics Data Analysis (NALDA) system. The objective of this project was to provide a CAI prototype that could be used as an enhancement to existing NALDA training. The CAI prototype project was performed in phases. The task undertaken in Phase I was to analyze the problem and the alternative solutions and to develop a set of recommendations on how best to proceed. The findings from Phase I are documented in Recommended CAI Approach for the NALDA System (Duncan et al., 1987). In Phase II, a structured design and specifications were developed, and a prototype CAI system was created. A report, NALDA CAI Prototype: Phase II Final Report, was written to record the findings and results of Phase II. NALDA CAI: Recommendations for an Advanced Instructional Model, is comprised of related papers encompassing research on computer aided instruction CAI, newly developing training technologies, instructional systems development, and an Advanced Instructional Model. These topics were selected because of their relevancy to the CAI needs of NALDA. These papers provide general background information on various aspects of CAI and give a broad overview of new technologies and their impact on the future design and development of training programs. The paper within have been index separately elsewhere.

  9. A Novel Task for the Investigation of Action Acquisition

    PubMed Central

    Stafford, Tom; Thirkettle, Martin; Walton, Tom; Vautrelle, Nicolas; Hetherington, Len; Port, Michael; Gurney, Kevin; Redgrave, Pete

    2012-01-01

    We present a behavioural task designed for the investigation of how novel instrumental actions are discovered and learnt. The task consists of free movement with a manipulandum, during which the full range of possible movements can be explored by the participant and recorded. A subset of these movements, the ‘target’, is set to trigger a reinforcing signal. The task is to discover what movements of the manipulandum evoke the reinforcement signal. Targets can be defined in spatial, temporal, or kinematic terms, can be a combination of these aspects, or can represent the concatenation of actions into a larger gesture. The task allows the study of how the specific elements of behaviour which cause the reinforcing signal are identified, refined and stored by the participant. The task provides a paradigm where the exploratory motive drives learning and as such we view it as in the tradition of Thorndike [1]. Most importantly it allows for repeated measures, since when a novel action is acquired the criterion for triggering reinforcement can be changed requiring a new action to be discovered. Here, we present data using both humans and rats as subjects, showing that our task is easily scalable in difficulty, adaptable across species, and produces a rich set of behavioural measures offering new and valuable insight into the action learning process. PMID:22675490

  10. Research on TRIZ and CAIs Application Problems for Technology Innovation

    NASA Astrophysics Data System (ADS)

    Li, Xiangdong; Li, Qinghai; Bai, Zhonghang; Geng, Lixiao

    In order to realize application of invent problem solve theory (TRIZ) and computer aided innovation software (CAIs) , need to solve some key problems, such as the mode choice of technology innovation, establishment of technology innovation organization network(TION), and achievement of innovative process based on TRIZ and CAIs, etc.. This paper shows that the demands for TRIZ and CAIs according to the characteristics and existing problem of the manufacturing enterprises. Have explained that the manufacturing enterprises need to set up an open TION of enterprise leading type, and achieve the longitudinal cooperation innovation with institution of higher learning. The process of technology innovation based on TRIZ and CAIs has been set up from researching and developing point of view. Application of TRIZ and CAIs in FY Company has been summarized. The application effect of TRIZ and CAIs has been explained using technology innovation of the close goggle valve product.

  11. Corrective Action Decision Document/Closure Report for Corrective Action Unit 137: Waste Disposal Sites, Nevada Test Site, Nevada (Revision 0) with ROTC 1 and 2

    SciTech Connect

    Krauss, Mark J

    2007-03-01

    The purpose of this Corrective Action Decision Document/Closure Report is to provide justification and documentation supporting the recommendation for closure of CAU 137 with no further corrective action. To achieve this, corrective action investigation (CAI) activities were performed from February 28 through August 17, 2006, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 137: Waste Disposal Sites. The purpose of the CAI was to fulfill the following data needs as defined during the data quality objective process: • Determine whether contaminants of concern (COCs) are present. • If COCs are present, determine their nature and extent. • Provide sufficient information and data to complete appropriate corrective actions. ROTC-1: Downgrade FFACO UR at CAU 137, CAS 07-23-02, Radioactive Waste Disposal Site to an Administrative UR. ROTC-2: Downgrade FFACO UR at CAU 137, CAS 01-08-01, Waste Disposal Site to an Administrative UR.

  12. Phase II Hydrologic Data for the Groundwater Flow and Contaminant Transport Model of Corrective Action Unit 98: Frenchman Flat, Nye County, Nevada, Rev. No.: 0

    SciTech Connect

    John McCord

    2004-12-01

    This report documents pertinent hydrologic data and data analyses as part of the Phase II Corrective Action Investigation (CAI) for Frenchman Flat (FF) Corrective Action Unit (CAU): CAU 98. The purpose of this data compilation and related analyses is to provide the primary reference to support the development of the Phase II FF CAU groundwater flow model.

  13. Phase II Contaminant Transport Parameters for the Groundwater Flow and Contaminant Transport Model of Corrective Action Unit 98: Frenchman Flat, Nye County, Nevada, Rev. No.: 0

    SciTech Connect

    DeNovio, Nicole M.; Bryant, Nathan; King, Chrissi B.; Bhark, Eric; Drellack, Sigmund L.; Pickens, John F.; Farnham, Irene; Brooks, Keely M.; Reimus, Paul; Aly, Alaa

    2005-04-01

    This report documents pertinent transport data and data analyses as part of the Phase II Corrective Action Investigation (CAI) for Frenchman Flat (FF) Corrective Action Unit (CAU) 98. The purpose of this data compilation and related analyses is to provide the primary reference to support parameterization of the Phase II FF CAU transport model.

  14. Examination and Application of Formative Evaluation for Author Utilization During the Preparation of a CAI Course.

    ERIC Educational Resources Information Center

    Ward, Marjorie Ellen

    A study was devised to investigate the use of formative evaluation during the preparation of a course entitled "Education of Visually Handicapped Children" designed for presentation to students through computer-assisted instruction (CAI). Various models for formative evaluation were examined, the Baker and Schutz cycle for instructional product…

  15. Corrective Action Investigation Plan for Corrective Action Unit 447: Project Shoal Area, Nevada Subsurface Site

    SciTech Connect

    DOE /NV

    1998-11-01

    This Corrective Action Investigation Plan (CAIP) describes the US Department of Energy's (DOE's) continued environmental investigation of the subsurface Project Shoal Area (PSA) Corrective Action Unit (CAU) 447. The PSA is located in the Sand Springs Mountains in Churchill County, Nevada, about 48 kilometers (km) (30 miles [mi]) southeast of Fallon, Nevada. Project Shoal was part of the Vela Uniform Program which was conducted to improve the US' ability to detect, identify, and locate underground nuclear detonations. The test consisted of detonating a 12-kiloton nuclear device deep underground in granitic rock to determine whether seismic waves produced by an underground nuclear test could be differentiated from seismic waves produced by a naturally occurring earthquake. The test was a joint effort conducted by the US Atomic Energy Commission (AEC) and the US Department of Defense (DoD) in October 1963 (AEC, 1964).

  16. Corrective Action Decision Document for Corrective Action Unit 563: Septic Systems, Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Grant Evenson

    2008-02-01

    This Corrective Action Decision Document has been prepared for Corrective Action Unit (CAU) 563, Septic Systems, in accordance with the Federal Facility Agreement and Consent Order (FFACO, 1996; as amended January 2007). The corrective action sites (CASs) for CAU 563 are located in Areas 3 and 12 of the Nevada Test Site, Nevada, and are comprised of the following four sites: •03-04-02, Area 3 Subdock Septic Tank •03-59-05, Area 3 Subdock Cesspool •12-59-01, Drilling/Welding Shop Septic Tanks •12-60-01, Drilling/Welding Shop Outfalls The purpose of this Corrective Action Decision Document is to identify and provide the rationale for the recommendation of a corrective action alternative (CAA) for the four CASs within CAU 563. Corrective action investigation (CAI) activities were performed from July 17 through November 19, 2007, as set forth in the CAU 563 Corrective Action Investigation Plan (NNSA/NSO, 2007). Analytes detected during the CAI were evaluated against appropriate final action levels (FALs) to identify the contaminants of concern (COCs) for each CAS. The results of the CAI identified COCs at one of the four CASs in CAU 563 and required the evaluation of CAAs. Assessment of the data generated from investigation activities conducted at CAU 563 revealed the following: •CASs 03-04-02, 03-59-05, and 12-60-01 do not contain contamination at concentrations exceeding the FALs. •CAS 12-59-01 contains arsenic and chromium contamination above FALs in surface and near-surface soils surrounding a stained location within the site. Based on the evaluation of analytical data from the CAI, review of future and current operations at CAS 12-59-01, and the detailed and comparative analysis of the potential CAAs, the following corrective actions are recommended for CAU 563.

  17. Corrective Action Decision Document/Closure Report for Corrective Action Unit 105: Area 2 Yucca Flat Atmospheric Test Sites, Nevada National Security Site, Nevada, Revision 1

    SciTech Connect

    Matthews, Patrick

    2014-01-01

    The purpose of this Corrective Action Decision Document/Closure Report is to provide justification and documentation supporting the recommendation that no further corrective action is needed for CAU 105 based on the implementation of the corrective actions. Corrective action investigation (CAI) activities were performed from October 22, 2012, through May 23, 2013, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 105: Area 2 Yucca Flat Atmospheric Test Sites; and in accordance with the Soils Activity Quality Assurance Plan, which establishes requirements, technical planning, and general quality practices.

  18. Corrective Action Decision Document/Closure Report for Corrective Action Unit 550: Smoky Contamination Area Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Matthews, Patrick K.

    2015-02-01

    This Corrective Action Decision Document/Closure Report presents information supporting the closure of Corrective Action Unit (CAU) 550: Smoky Contamination Area, Nevada National Security Site, Nevada. CAU 550 includes 19 corrective action sites (CASs), which consist of one weapons-related atmospheric test (Smoky), three safety experiments (Ceres, Oberon, Titania), and 15 debris sites (Table ES-1). The CASs were sorted into the following study groups based on release potential and technical similarities: • Study Group 1, Atmospheric Test • Study Group 2, Safety Experiments • Study Group 3, Washes • Study Group 4, Debris The purpose of this document is to provide justification and documentation supporting the conclusion that no further corrective action is needed for CAU 550 based on implementation of the corrective actions listed in Table ES-1. Corrective action investigation (CAI) activities were performed between August 2012 and October 2013 as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 550: Smoky Contamination Area; and in accordance with the Soils Activity Quality Assurance Plan. The approach for the CAI was to investigate and make data quality objective (DQO) decisions based on the types of releases present. The purpose of the CAI was to fulfill data needs as defined during the DQO process. The CAU 550 dataset of investigation results was evaluated based on a data quality assessment. This assessment demonstrated the dataset is complete and acceptable for use in fulfilling the DQO data needs.

  19. Computer System Requirements for CAI/CMI Research.

    ERIC Educational Resources Information Center

    Fitzhugh, Robert J.

    This paper oriented for new researchers entering the field of CAI research discusses the research experience in this area, outlines some of the important computer requirements of CAI research, and proposes a conservative computer development strategy to meet those requirements. The development of PLATO and TICCIT are described as examples of the…

  20. An Intelligent CAI Monitor and Generative Tutor. Final Report.

    ERIC Educational Resources Information Center

    Koffman, Elliot B.; Perry, James

    This final report summarizes research findings and presents a model for generative computer assisted instruction (CAI) with respect to its usefulness in the classroom environment. Methods used to individualize instruction, and the evolution of a procedure used to select a concept for presentation to a student with the generative CAI system are…

  1. A CAI Study of Learning Geologic Time and Evolution.

    ERIC Educational Resources Information Center

    Young, James P.; Stolurow, Lawrence M.

    Twenty-two college students in science education were given an adjunctive computer-assisted instruction (CAI) program by means of typewriter consoles and computer-controlled colored slide presentations of critical information. Students were pretested, told how to respond at the student console, taught by the Harvard CAI System, and posttested. The…

  2. A Pilot CAI Scheme for the Malaysian Secondary Education System.

    ERIC Educational Resources Information Center

    Rao, A. Kanakaratnam; Rao, G. S.

    1982-01-01

    A multi-phase computer aided instruction (CAI) scheme for Malaysian Secondary Schools and Matriculation Centres attached to local universities is presented as an aid for improving instruction and for solving some problems presently faced by the Malaysian Secondary Education System. Some approaches for successful implementation of a CAI scheme are…

  3. Fifteen Years of Teaching Elementary Applied Statistics Using CAI.

    ERIC Educational Resources Information Center

    Hunka, S.

    A computer-assisted instructional (CAI) course in applied statistics has been taught for 15 years in the Faculty of Education at the University of Manitoba. The CAI courseware was originally created to be the primary mode of instruction for the course, and it is very extensive in terms of content and style of presentation. The course includes 14…

  4. The Effectiveness of CAI Designed for the Hearing-Impaired.

    ERIC Educational Resources Information Center

    Fogel, Nancy S.

    Two pilot studies probed effectiveness of linguistically controlled, highly visual computer-assisted instruction (CAI) for English grammar instruction with hearing-impaired high school students (N=29 in the first study and N=71 in the second). Results from the first study suggested that state-of-the-art CAI designed specifically for use with this…

  5. Corrective Action Decision Document/Closure Report for Corrective Action Unit 232: Area 25 Sewage Lagoons, Nevada Test Site, Nevada

    SciTech Connect

    US Department of Energy Nevada Operations Office

    1999-12-23

    This Corrective Action Decision Document/Closure Report (CADD/CR) has been prepared for Corrective Action Unit (CAU) 232, Area 25 Sewage Lagoons, in accordance with the Federal Facility Agreement and Consent Order. Located at the Nevada Test Site in Nevada, approximately 65 miles northwest of Las Vegas, CAU 232 is comprised of Corrective Action Site 25-03-01, Sewage Lagoon. This CADD/CR identifies and rationalizes the U.S. Department of Energy, Nevada Operations Office's (DOE/NV's) recommendation that no corrective action is deemed necessary for CAU 232. The Corrective Action Decision Document and Closure Report have been combined into one report because sample data collected during the July 1999 corrective action investigation (CAI) activities disclosed no evidence of contamination at the site. Contaminants of potential concern (COPCs) addressed during the CAI included total volatile organic compounds, total semivolatile organic compounds, total Resource Conservation and Recovery Act metals, total pesticides, total herbicides, total petroleum hydrocarbons (gasoline and diesel/oil range), polychlorinated biphenyls, isotopic uranium, isotopic plutonium, strontium-90, and gamma-emitting radionuclides. The data confirmed that none of the COPCs identified exceeded preliminary action levels outlined in the CAIP; therefore, no corrective actions were necessary for CAU 232. After the CAI, best management practice activities were completed and included installation of a fence and signs to limit access to the lagoons, cementing Manhole No. 2 and the diverter box, and closing off influent and effluent ends of the sewage lagoon piping. As a result of the CAI, the DOE/NV recommended that: (1) no further actions were required; (2) no Corrective Action Plan would be required; and (3) no use restrictions were required to be placed on the CAU.

  6. Investigation of the low-level modulated light action

    NASA Astrophysics Data System (ADS)

    Antonov, Sergei N.; Sotnikov, V. N.; Koreneva, L. G.

    1994-07-01

    Now there exists no clear complete knowledge about mechanisms and pathways by which low level laser bioactivation works. Modulated laser light action has been investigated two new ways: dynamical infrared thermography and computing image of living brain. These ways permit observation in real time laser action on peripheral blood flow, reflex reactions to functional probes, thermoregulation mechanisms as well as brain electrical activity changes of humans. We have designed a universal apparatus which produced all regimes of the output laser light. It has a built-in He-Ne laser with an acousto-optic modulator and an infrared GaAs laser. The device provided spatial combination of both the light beams and permitted us to irradiate an object both separately and simultaneously. This research shows that the most effective frequencies range from several to dozens of hertz. The duty factor and frequency scanning are also important. On the basis of these results in Russian clinics new treatment methods using modulated light are applied in practical neurology, gynecology, etc.

  7. Corrective Action Investigation Plan for Corrective Action Unit 554: Area 23 Release Site, Nevada Test Site, Nevada, Rev. No.: 0

    SciTech Connect

    David A. Strand

    2004-10-01

    This Corrective Action Investigation Plan (CAIP) contains project-specific information for conducting site investigation activities at Corrective Action Unit (CAU) 554: Area 23 Release Site, Nevada Test Site, Nevada. Information presented in this CAIP includes facility descriptions, environmental sample collection objectives, and criteria for the selection and evaluation of environmental samples. Corrective Action Unit 554 is located in Area 23 of the Nevada Test Site, which is 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 554 is comprised of one Corrective Action Site (CAS), which is: 23-02-08, USTs 23-115-1, 2, 3/Spill 530-90-002. This site consists of soil contamination resulting from a fuel release from underground storage tanks (USTs). Corrective Action Site 23-02-08 is being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation prior to evaluating corrective action alternatives and selecting the appropriate corrective action for this CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document for CAU 554. Corrective Action Site 23-02-08 will be investigated based on the data quality objectives (DQOs) developed on July 15, 2004, by representatives of the Nevada Division of Environmental Protection; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; and contractor personnel. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 554.

  8. New Titanium Isotope Data for Allende and Efremovka CAIs

    NASA Astrophysics Data System (ADS)

    Leya, Ingo; Schönbächler, Maria; Krähenbühl, Urs; Halliday, Alex N.

    2009-09-01

    We measured the titanium (Ti) isotope composition, i.e., 50Ti/47Ti, 48Ti/47Ti, and 46Ti/47Ti, in five calcium-rich-aluminum-rich refractory inclusions (CAIs) from the oxidized CV3 chondrite Allende and in two CAIs from the reduced CV3 chondrite Efremovka. Our data indicate that CAIs are enriched in 50Ti/47Ti and 46Ti/47Ti and are slightly depleted in 48Ti/47Ti compared to normal Ti defined by ordinary chondrites, eucrites, ureilites, mesosiderites, Earth, Moon, and Mars. Some CAIs have an additional 50Ti excess of ~8ɛ relative to bulk carbonaceous chondrites, which are enriched in 50Ti by ~2ɛ relative to terrestrial values, leading to a total excess of ~10ɛ. This additional 50Ti excess is correlated with nucleosynthetic anomalies found in 62Ni and 96Zr, all indicating an origin from a neutron-rich stellar source. Bulk carbonaceous chondrites show a similar trend, however, the extent of the anomalies is either less than or similar to the smallest anomalies seen in CAIs. Mass balance calculations suggest that bulk Allende Ti possibly consists of a mixture of at least two Ti components, anomalous Ti located in CAIs and a normal component possibly for matrix and chondrules. This argues for a heterogeneous distribution of Ti isotopes in the solar system. The finding that anomalous Ti is concentrated in CAIs suggests that CAIs formed in a specific region of the solar system and were, after their formation, not homogeneously redistributed within the solar system. Combining the CAI data with improved model predictions for early solar system irradiation effects indicates that a local production scenario for the relatively short lived radionuclides can be excluded, because the production of, e.g., 10Be, 26Al, and 41Ca, would result in a significant collateral shift in Ti isotopes, which is not seen in the measured data.

  9. CAI System of Obunsha Co., Ltd. Using CD-ROM

    NASA Astrophysics Data System (ADS)

    Todokoro, Shigeru; Mukai, Yoshihiro

    This paper introduces the present status of R & D on CAI teaching materials in Obunsha Co., Ltd. Characteristics of CAI using CD-ROM as well as Culture-in CAI Teaching Materials System for junior high school English are described. The system consists of CD-ROM driver XM-2000 and Pasopia 700 of Toshiba Corporation having both features of CD-ROM and FD. CD-ROM stores vast amount of voice data while FD does text and graphics data. It is a frame-oriented mode system enabling to raise learning effect.

  10. Corrective Action Investigation Plan for Corrective Action Unit 560: Septic Systems, Nevada Test Site, Nevada with ROTC1, Revision 0

    SciTech Connect

    Grant Evenson

    2008-05-01

    Corrective Action Unit (CAU) 560 is located in Areas 3 and 6 of the Nevada Test Site, which is approximately 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 560 is comprised of the seven corrective action sites (CASs) listed below: • 03-51-01, Leach Pit • 06-04-02, Septic Tank • 06-05-03, Leach Pit • 06-05-04, Leach Bed • 06-59-03, Building CP-400 Septic System • 06-59-04, Office Trailer Complex Sewage Pond • 06-59-05, Control Point Septic System These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation before evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on January 22, 2008, by representatives from the Nevada Division of Environmental Protection; U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office; Stoller-Navarro Joint Venture; and National Security Technologies, LLC. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 560.

  11. Astrophysics of CAI formation as revealed by silicon isotope LA-MC-ICPMS of an igneous CAI

    NASA Astrophysics Data System (ADS)

    Shahar, Anat; Young, Edward D.

    2007-05-01

    Silicon isotope ratios of a typical CAI from the Leoville carbonaceous chondrite, obtained in situ by laser ablation MC-ICPMS, together with existing 25Mg/ 24Mg data, reveal a detailed picture of the astrophysical setting of CAI melting and subsequent heating. Models for the chemical and isotopic effects of evaporation of the molten CAI are used to produce a univariant relationship between PH 2 and time during melting. The result shows that this CAI was molten for a cumulative time of no more than 70 days and probably less than 15 days depending on temperature. The object could have been molten for an integrated time of just a few hours if isotope ratio zoning was eliminated after melting by high subsolidus temperatures (e.g., > 1300 K) for ˜ 500 yr. In all cases subsolidus heating sufficient to produce diffusion-limited isotope fractionation at the margin of the solidified CAI is required. These stable isotope data point to a two-stage history for this igneous CAI involving melting for a cumulative timescale of hours to months followed by subsolidus heating for years to hundreds of years. The thermobarometric history deduced from combining Si and Mg isotope ratio data implicates thermal processing in the disk, perhaps by passage through shockwaves, following melting. This study underscores the direct link between the meaning of stable isotope ratio zoning, or lack thereof, and the inferred astrophysical setting of melting and subsequent processing of CAIs.

  12. The Relative Effectiveness of Computer Assisted Instruction (CAI) for Teaching Students To Read English.

    ERIC Educational Resources Information Center

    Thompson, Richard A.

    In a review of research on computer assisted instruction (CAI) related to reading, evidence collected provides tentative conclusions about CAI effectiveness. CAI was effective as an instructional medium in the surveyed studies. In a number of instances, CAI groups achieved higher scores than the control groups. Some studies indicated that CAI…

  13. A CAI in the Ivuna CI1 Chondrite

    NASA Technical Reports Server (NTRS)

    Frank, David R.; Zolensky, M.; Martinez, J.; Mikouchi, T.; Ohsumi, K.; Hagiya, K.; Satake, W.; Le, L.; Ross, D.; Peslier, A.

    2011-01-01

    We have recently discovered the first well-preserved calcium aluminum-rich inclusion (CAI) in a CI1 chondrite (Ivuna). Previously, all CI1 chondrites were thought to be devoid of preserved CAI and chondrules due to the near total aqueous alteration to which their parent body (bodies) have been subjected. The CAI is roughly spherical, but with a slight teardrop geometry and a maximum diameter of 170 microns (fig. 1). It lacks any Wark-Lovering Rim. Incipient aqueous alteration, and probably shock, have rendered large portions of the CAI poorly crystalline. It is extremely fine-grained, with only a few grains exceeding 10 microns. We have performed electron microprobe analyses (EPMA), FEG-SEM imaging and element mapping, as well as electron back-scattered diffraction (EBSD) and synchrotron X-ray diffraction (SXRD) in order to determine the fundamental characteristics of this apparently unique object.

  14. Corrective Action Investigation Plan for Corrective Action Unit 232: Area 25 Sewage Lagoons, Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    USDOE /NV

    1999-05-01

    The Corrective Action Investigation Plan for Corrective Action Unit 232, Area 25 Sewage Lagoons, has been developed in accordance with the Federal Facility Agreement and Consent Order that was agreed to by the U.S. Department of Energy, Nevada Operations Office; the State of Nevada Division of Environmental Protection; and the U. S. Department of Defense. Corrective Action Unit 232 consists of Corrective Action Site 25-03-01, Sewage Lagoon. Corrective Action Unit 232, Area 25 Sewage Lagoons, received sanitary effluent from four buildings within the Test Cell ''C'' Facility from the mid-1960s through approximately 1996. The Test Cell ''C'' Facility was used to develop nuclear propulsion technology by conducting nuclear test reactor studies. Based on the site history collected to support the Data Quality Objectives process, contaminants of potential concern include volatile organic compounds, semivolatile organic compounds, Resource Conservation and Recovery Act metals, petroleum hydrocarbons, polychlorinated biphenyls, pesticides, herbicides, gamma emitting radionuclides, isotopic plutonium, isotopic uranium, and strontium-90. A detailed conceptual site model is presented in Section 3.0 and Appendix A of this Corrective Action Investigation Plan. The conceptual model serves as the basis for the sampling strategy. Under the Federal Facility Agreement and Consent Order, the Corrective Action Investigation Plan will be submitted to the Nevada Division of Environmental Protection for approval. Field work will be conducted following approval of the plan. The results of the field investigation will support a defensible evaluation of corrective action alternatives in the Corrective Action Decision Document.

  15. Corrective Action Decision Document/Closure Report for Corrective Action Unit 266: Area 25 Building 3124 Leachfield, Nevada Test Site, Nevada

    SciTech Connect

    NNSA /NV

    2000-02-17

    This Corrective Action Decision Document/Closure Report (CADD/CR) was prepared for Corrective Action Unit (CAU) 266, Area 25 Building 3124 Leachfield, in accordance with the Federal Facility Agreement and Consent Order. Located in Area 25 at the Nevada Test Site in Nevada, CAU 266 includes Corrective Action Site (CAS) 25-05-09. The Corrective Action Decision Document and Closure Report were combined into one report because sample data collected during the corrective action investigation (CAI) indicated that contaminants of concern (COCs) were either not present in the soil, or present at concentrations not requiring corrective action. This CADD/CR identifies and rationalizes the U.S. Department of Energy, Nevada Operations Office's recommendation that no corrective action was necessary for CAU 266. From February through May 1999, CAI activities were performed as set forth in the related Corrective Action Investigation Plan. Analytes detected during the three-stage CAI of CAU 266 were evaluated against preliminary action levels (PALs) to determine COCs, and the analysis of the data generated from soil collection activities indicated the PALs were not exceeded for total volatile/semivolatile organic compounds, total petroleum hydrocarbons, polychlorinated biphenyls, total Resource Conservation and Recovery Act metals, gamma-emitting radionuclides, isotopic uranium/plutonium, and strontium-90 for any of the samples. However, COCs were identified in samples from within the septic tank and distribution box; and the isotopic americium concentrations in the two soil samples did exceed PALs. Closure activities were performed at the site to address the COCs identified in the septic tank and distribution box. Further, no use restrictions were required to be placed on CAU 266 because the CAI revealed soil contamination to be less than the 100 millirems per year limit established by DOE Order 5400.5.

  16. FIB-NanoSIMS-TEM Coordinated Study of a Wark-Lovering Rim in a Vigarano Type A CAI

    NASA Technical Reports Server (NTRS)

    Cai, A.; Ito, M.; Keller, L. P.; Ross, D. K.; Nakamura-Messenger, K.

    2010-01-01

    Wark-Lovering (WL) rims are thin multi layered mineral sequences that surround most Ca, Al-rich inclusions (CAIs). Unaltered WL rims are composed of the same primary high temperature minerals as CAIs, such as melilite, spinel, pyroxene, hibonite, perovskite, anorthite and olivine. It is still unclear whether the rim minerals represent a different generation formed by a separate event from their associated CAIs or are a byproduct of CAI formation. Several models have been proposed for the origins of WL rims including condensation, flashheating, reaction of a CAI with a Mg-Si-rich reservoir (nebular gas or solid); on the basis of mineralogy, abundances of trace elements, O and Mg isotopic studies. Detailed mineralogical characterizations of WL rims at micrometer to nanometer scales have been obtained by TEM observations, but so far no coordinated isotopic - mineralogical studies have been performed. Thus, we have applied an O isotopic imaging technique by NanoSIMS 50L to investigate heterogeneous distributions of O isotopic ratios in minerals within a cross section of a WL rim prepared using a focused ion beam (FIB) instrument. After the isotopic measurements, we determine the detailed mineralogy and microstructure of the same WL FIB section to gain insight into its petrogenesis. Here we present preliminary results from O isotopic and elemental maps by NanoSIMS and mineralogical analysis by FE-SEM of a FIB section of a WL rim in the Vigarano reduced CV3 chondrite.

  17. Spontaneous Action and Transformative Learning: Empirical Investigations and Pragmatist Reflections

    ERIC Educational Resources Information Center

    Nohl, Arnd-Michael

    2009-01-01

    Whereas present theories of transformative learning tend to focus on the rational and reflective actor, in this article it is suggested that spontaneous action may play a decisive role in transformative learning too. In the spontaneity of action, novelty finds its way into life, gains momentum, is respected by others and reflected by the actor.…

  18. Corrective Action Investigation plan for Corrective Action Unit 263: Area 25 Building 4839 Leachfield, Nevada Test Site, Nevada, March 1999

    SciTech Connect

    ITLV

    1999-03-01

    The Corrective Action Investigation Plan for Corrective Action Unit 263, the Area 25 Building 4839 Leachfield, has been developed in accordance with the Federal Facility Agreement and Consent Order that was agreed to by the US Department of Energy, Nevada Operations Office; the Nevada Division of Environmental Protection; and the US Department of Defense. Corrective Action Unit 263 is comprised of the Corrective Action Site 25-05-04 sanitary leachfield and associated collection system. This Corrective Action Investigation Plan is used in combination with the Work Plan for Leachfield Corrective Action Units: Nevada Test Site and Tonopah Test Range, Nevada (DOE/NV, 1998d). The Leachfield Work Plan was developed to streamline investigations at Leachfield Corrective Action Units by incorporating management, technical, quality assurance, health and safety, public involvement, field sampling, and waste management information common to a set of Corrective Action Units with similar site histories and characteristics into a single document that can be referenced. This Corrective Action Investigation Plan provides investigative details specific to Corrective Action Unit 263. Corrective Action Unit 263 is located southwest of Building 4839, in the Central Propellant Storage Area. Operations in Building 4839 from 1968 to 1996 resulted in effluent releases to the leachfield and associated collection system. In general, effluent released to the leachfield consisted of sanitary wastewater from a toilet, urinal, lavatory, and drinking fountain located within Building 4839. The subsurface soils in the vicinity of the collection system and leachfield may have been impacted by effluent containing contaminants of potential concern generated by support activities associated with the Building 4839 operations.

  19. Corrective Action Investigation Plan for Corrective Action Unit 552: Area 12 Muckpile and Ponds, Nevada Test Site, Nevada: Revision 0

    SciTech Connect

    U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office

    2004-04-06

    This Corrective Action Investigation Plan contains the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office's approach for collecting the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 552: Area 12 Muckpile and Ponds, Nevada Test Site (NTS), Nevada, under the Federal Facility Agreement and Consent Order. Located in Area 12 on the NTS, CAU 552 consists of two Corrective Action Sites (CASs): 12-06-04, Muckpile; 12-23-05, Ponds. Corrective Action Site 12-06-04 in Area 12 consists of the G-Tunnel muckpile, which is the result of tunneling activities. Corrective Action Site 12-23-05 consists of three dry ponds adjacent to the muckpile. The toe of the muckpile extends into one of the ponds creating an overlap of two CASs. The purpose of the investigation is to ensure that adequate data are collected to provide sufficient and reliable information to identify, evaluate, and select technic ally viable corrective actions. The results of the field investigation will support a defensible evaluation of corrective action alternatives in the corrective action decision document.

  20. Corrective Action Investigation Plan for Corrective Action Unit 374: Area 20 Schooner Unit Crater Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews

    2010-02-01

    Corrective Action Unit 374 is located in Areas 18 and 20 of the Nevada Test Site, which is approximately 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 374 comprises the five corrective action sites (CASs) listed below: • 18-22-05, Drum • 18-22-06, Drums (20) • 18-22-08, Drum • 18-23-01, Danny Boy Contamination Area • 20-45-03, U-20u Crater (Schooner) These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable CAAs that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on October 20, 2009, by representatives of the Nevada Division of Environmental Protection and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 374.

  1. In Situ Trace Element Analysis of an Allende Type B1 CAI: EK-459-5-1

    NASA Technical Reports Server (NTRS)

    Jeffcoat, C. R.; Kerekgyarto, A.; Lapen, T. J.; Andreasen, R.; Righter, M.; Ross, D. K.

    2014-01-01

    Variations in refractory major and trace element composition of calcium, aluminum-rich inclusions (CAIs) provide constraints on physical and chemical conditions and processes in the earliest stages of the Solar System. Previous work indicates that CAIs have experienced complex histories involving, in many cases, multiple episodes of condensation, evaporation, and partial melting. We have analyzed major and trace element abundances in two core to rim transects of the melilite mantle as well as interior major phases of a Type B1 CAI (EK-459-5-1) from Allende by electron probe micro-analyzer (EPMA) and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) to investigate the behavior of key trace elements with a primary focus on the REEs Tm and Yb.

  2. Investigating social gaze as an action-perception online performance

    PubMed Central

    Grynszpan, Ouriel; Simonin, Jérôme; Martin, Jean-Claude; Nadel, Jacqueline

    2012-01-01

    Gaze represents a major non-verbal communication channel in social interactions. In this respect, when facing another person, one's gaze should not be examined as a purely perceptive process but also as an action-perception online performance. However, little is known about processes involved in the real-time self-regulation of social gaze. The present study investigates the impact of a gaze-contingent viewing window on fixation patterns and the awareness of being the agent moving the window. In face-to-face scenarios played by a virtual human character, the task for the 18 adult participants was to interpret an equivocal sentence which could be disambiguated by examining the emotional expressions of the character speaking. The virtual character was embedded in naturalistic backgrounds to enhance realism. Eye-tracking data showed that the viewing window induced changes in gaze behavior, notably longer visual fixations. Notwithstanding, only half of the participants ascribed the window displacements to their eye movements. These participants also spent more time looking at the eyes and mouth regions of the virtual human character. The outcomes of the study highlight the dissociation between non-volitional gaze adaptation and the self-ascription of agency. Such dissociation provides support for a two-step account of the sense of agency composed of pre-noetic monitoring mechanisms and reflexive processes, linked by bottom-up and top-down processes. We comment upon these results, which illustrate the relevance of our method for studying online social cognition, in particular concerning autism spectrum disorders (ASD) where the poor pragmatic understanding of oral speech is considered linked to visual peculiarities that impede facial exploration. PMID:22529796

  3. Corrective Action Investigation Plan for Corrective Action Unit 365: Baneberry Contamination Area, Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews

    2010-12-01

    Corrective Action Unit 365 comprises one corrective action site (CAS), CAS 08-23-02, U-8d Contamination Area. This site is being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for the CAS. The results of the field investigation will support a defensible evaluation of viable CAAs that will be presented in the Corrective Action Decision Document. The site will be investigated based on the data quality objectives (DQOs) developed on July 6, 2010, by representatives of the Nevada Division of Environmental Protection and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for the Baneberry site. The primary release associated with Corrective Action Unit 365 was radiological contamination from the Baneberry nuclear test. Baneberry was an underground weapons-related test that vented significant quantities of radioactive gases from a fissure located in close proximity to ground zero. A crater formed shortly after detonation, which stemmed part of the flow from the fissure. The scope of this investigation includes surface and shallow subsurface (less than 15 feet below ground surface) soils. Radionuclides from the Baneberry test with the potential to impact groundwater are included within the Underground Test Area Subproject. Investigations and corrective actions associated with the Underground Test Area Subproject include the radiological inventory resulting from the Baneberry test.

  4. Corrective Action Investigation Plan for Corrective Action Unit 573: Alpha Contaminated Sites, Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Matthews, Patrick

    2014-05-01

    Corrective Action Unit (CAU) 573 is located in Area 5 of the Nevada National Security Site, which is approximately 65 miles northwest of Las Vegas, Nevada. CAU 573 is a grouping of sites where there has been a suspected release of contamination associated with non-nuclear experiments and nuclear testing. This document describes the planned investigation of CAU 573, which comprises the following corrective action sites (CASs): • 05-23-02, GMX Alpha Contaminated Area • 05-45-01, Atmospheric Test Site - Hamilton These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives.

  5. Corrective action investigation plan: Area 2 Photo Skid 16 Wastewater Pit, Corrective Action Unit 332. Revision 1

    SciTech Connect

    1997-01-01

    This Corrective Action Investigation Plan (CAIP) contains a detailed description and plan for an environmental investigation of the Area 2 Photo Skid 16 Wastewater Pit. The site is located in Area 2 of the Nevada Test Site. The Photo Skid Wastewater Pit was used for disposal of photochemical process waste, and there is a concern that such disposal may have released photochemicals and metals to the soil beneath the pit and adjacent to it. The purpose of this investigation is to identify the presence and nature of contamination present in and adjacent to the wastewater pit and to determine the appropriate course of environmental response action for the site. The potential courses of action for the site are clean closure through remediation, closure in place (with or without remediation), or no further action.

  6. NEW TITANIUM ISOTOPE DATA FOR ALLENDE AND EFREMOVKA CAIs

    SciTech Connect

    Leya, Ingo; Schoenbaechler, Maria; Kraehenbuehl, Urs; Halliday, Alex N.

    2009-09-10

    We measured the titanium (Ti) isotope composition, i.e., {sup 50}Ti/{sup 47}Ti, {sup 48}Ti/{sup 47}Ti, and {sup 46}Ti/{sup 47}Ti, in five calcium-rich-aluminum-rich refractory inclusions (CAIs) from the oxidized CV3 chondrite Allende and in two CAIs from the reduced CV3 chondrite Efremovka. Our data indicate that CAIs are enriched in {sup 50}Ti/{sup 47}Ti and {sup 46}Ti/{sup 47}Ti and are slightly depleted in {sup 48}Ti/{sup 47}Ti compared to normal Ti defined by ordinary chondrites, eucrites, ureilites, mesosiderites, Earth, Moon, and Mars. Some CAIs have an additional {sup 50}Ti excess of {approx}8{epsilon} relative to bulk carbonaceous chondrites, which are enriched in {sup 50}Ti by {approx}2{epsilon} relative to terrestrial values, leading to a total excess of {approx}10{epsilon}. This additional {sup 50}Ti excess is correlated with nucleosynthetic anomalies found in {sup 62}Ni and {sup 96}Zr, all indicating an origin from a neutron-rich stellar source. Bulk carbonaceous chondrites show a similar trend, however, the extent of the anomalies is either less than or similar to the smallest anomalies seen in CAIs. Mass balance calculations suggest that bulk Allende Ti possibly consists of a mixture of at least two Ti components, anomalous Ti located in CAIs and a normal component possibly for matrix and chondrules. This argues for a heterogeneous distribution of Ti isotopes in the solar system. The finding that anomalous Ti is concentrated in CAIs suggests that CAIs formed in a specific region of the solar system and were, after their formation, not homogeneously redistributed within the solar system. Combining the CAI data with improved model predictions for early solar system irradiation effects indicates that a local production scenario for the relatively short lived radionuclides can be excluded, because the production of, e.g., {sup 10}Be, {sup 26}Al, and {sup 41}Ca, would result in a significant collateral shift in Ti isotopes, which is not seen in the

  7. Corrective Action Investigation Plan for Corrective Action Unit 240: Area 25 Vehicle Washdown Nevada Test Site, Nevada

    SciTech Connect

    DOE /NV

    1999-01-25

    This Corrective Action Investigation Plan (CAIP) has been developed in accordance with the Federal Facility Agreement and Consent Order (FFACO) that was agreed to by the US Department of Energy, Nevada Operations Office (DOE/NV); the State of Nevada Division of Environmental Protection (NDEP); and the US Department of Defense (FFACO, 1996). The CAIP is a document that provides or references all of the specific information for investigation activities associated with Corrective Action Units (CAUs) or Corrective Action Sites (CASs). According to the FFACO, CASs are sites potentially requiring corrective action(s) and may include solid waste management units or individual disposal or release sites (FFACO, 1996). Corrective Action Units consist of one or more CASs grouped together based on geography, technical similarity, or agency responsibility for the purpose of determining corrective actions. This CAIP contains the environmental sample collection objectives and the criteria for conducting site investigation activities at CAU 240, Area 25 Vehicle Washdown, which is located on the Nevada Test Site (NTS).

  8. Corrective Action Investigation Plan for Corrective Action Unit 232: Area 25 Sewage Lagoons Nevada Test Site, Nevada

    SciTech Connect

    DOE /NV Operations Office

    1999-05-01

    This Corrective Action Investigation Plan (CAIP) has been developed in accordance with the Federal Facility Agreement and Consent Order (FFACO) (1996) that was agreed to by the US Department of Energy, Nevada Operations Office (DOE/NV); the State of Nevada Division of Environmental Protection (NDEP); and the US Department of Defense. The CAIP is a document that provides or references all of the specific information for investigation activities associated with Corrective Action Units (CAUs) or Corrective Action Sites (CASs). According to the FFACO, CASs are sites potentially requiring corrective action(s) and may include solid waste management units or individual disposal or release sites. A CAU consists of one or more CASs grouped together based on geography, technical similarity, or agency responsibility for the purpose of determining corrective actions. This CAIP contains the environmental sample collection objectives and criteria for conducting site investigation activities at CAU 232, Area 25 Sewage Lagoons. Corrective Action Unit 232 consists of CAS 25-03-01, Sewage Lagoon, located in Area 25 of the Nevada Test Site (NTS). The NTS is approximately 65 miles (mi) northwest of Las Vegas, Nevada (Figure 1-1) (DOE/NV, 1996a). The Area 25 Sewage Lagoons (Figure 1-2) (IT, 1999b) are located approximately 0.3 mi south of the Test Cell 'C' (TCC) Facility and were used for the discharge of sanitary effluent from the TCC facility. For purposes of this discussion, this site will be referred to as either CAU 232 or the sewage lagoons.

  9. The Biodiversity Community Action Project: An STS Investigation

    ERIC Educational Resources Information Center

    Aidin, Amirshokoohi; Mahsa, Kazempour

    2010-01-01

    The Biodiversity Community Action Project is a stimulating and vigorous project that allows students to gain an in-depth understanding of the interconnection between organisms and their environments as well as the connection of science to their lives and society. It addresses key content standards in the National Science Education Standards and…

  10. Investigating the Benefits of Participatory Action Research for Environmental Education

    ERIC Educational Resources Information Center

    Bywater, Krista

    2014-01-01

    Environmental education (EE) continues to focus on enhancing people's ecological knowledge to encourage sustainable actions. This deficit approach presumes that once informed about environmental harms, people will work towards sustainable solutions for healthy societies. Yet research overwhelmingly demonstrates that knowledge of environmental…

  11. Limited subsolidus diffusion in type B1 CAI: Evidence from Ti distribution in spinel

    NASA Technical Reports Server (NTRS)

    Meeker, G. P.; Quick, J. E.; Paque, Julie M.

    1993-01-01

    Most models of calcium aluminum-rich inclusions (CAI) have focused on early stages of formation by equilibrium crystallization of a homogeneous liquid. Less is known about the subsolidus cooling history of CAI. Chemical and isotopic heterogeneties on a scale of tens to hundreds of micrometers (e.g. MacPherson et al. (1989) and Podosek, et al. (1991)) suggest fairly rapid cooling with a minimum of subsolidus diffusion. However, transmission electron microscopy indicates that solid state diffusion may have been an important process at a smaller scale (Barber et al. 1984). If so, chemical evidence for diffusion could provide constraints on cooling times and temperatures. With this in mind, we have begun an investigation of the Ti distribution in spinels from two type B1 CAI from Allende to determine if post-crystallization diffusion was a significant process. The type B1 CAIs, 3529Z and 5241 have been described by Podosek et al. (1991) and by El Goresy et al. (1985) and MacPherson et al. (1989). We have analyzed spinels in these inclusions using the electron microprobe. These spinels are generally euhedral, range in size from less than 10 to 15 micron and are poikilitically enclosed by millimeter-sized pyroxene, melilite, and anorthite. Analyses were obtained from both the mantles and cores of the inclusions. Compositions of pyroxene in the vicinity of individual spinel grains were obtained by analyzing at least two points on opposite sides of the spinel and averaging the compositions. The pyroxene analyses were obtained within 15 microns of the spinel-pyroxene interface. No compositional gradients were observed within single spinel crystals. Ti concentrations in spinels included within pyroxene, melilite, and anorthite are presented.

  12. Corrective action investigation plan for the Roller Coaster RADSAFE Area, Corrective Action Unit 407, Tonopah Test Range, Nevada

    SciTech Connect

    1998-04-01

    This Corrective Action Investigation Plan (CAIP) has been developed in accordance with the Federal Facility Agreement and Consent Order (FFACO) that was agreed to by the US Department of Energy, Nevada Operations Office (DOE/NV); the State of Nevada Division of Environmental Protection (NDEP); and the US Department of Defense (FFACO, 1996). The CAIP is a document that provides or references all of the specific information for investigation activities associated with Corrective Action Units (CAUs) or Corrective Action Sites (CASs). According to the FFACO (1996), CASs are sites potentially requiring corrective action(s) and may include solid waste management units or individual disposal or release sites. CAUs consist of one or more CASs grouped together based on geography, technical similarity, or agency responsibility for the purpose of determining corrective actions. This CAIP contains the environmental sample collection objectives and the criteria for conducting site investigation activities at CAU No. 407, the Roller Coaster RADSAFE Area (RCRSA) which is located on the Tonopah Test Range (TTR). The TTR, included in the Nellis Air Force Range Complex, is approximately 255 km (140 mi) northwest of Las Vegas, Nevada. CAU No. 407 is comprised of only one CAS (TA-23-001-TARC). The RCRSA was used during May and June 1963 to decontaminate vehicles, equipment, and personnel from the Clean Slate tests. The surface and subsurface soils are likely to have been impacted by plutonium and other contaminants of potential concern (COPCs) associated with decontamination activities at this site. The purpose of the corrective action investigation described in this CAIP is to: identify the presence and nature of COPCs; determine the vertical and lateral extent of COPCs; and provide sufficient information and data to develop and evaluate appropriate corrective actions for the CAS.

  13. Corrective Action Investigation Plan for Corrective Action Unit 565: Stored Samples, Nevada Test Site, Nevada, Rev. No.: 0

    SciTech Connect

    Wickline, Alfred; McCall, Robert

    2006-08-01

    Corrective Action Unit (CAU) 565 is located in Area 26 of the Nevada Test Site, which is 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 565 is comprised of one corrective action site (CAS) listed--CAS 26-99-04, Ground Zero Soil Samples. This site is being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend closure of CAU 565. Additional information will be obtained by conducting a corrective action investigation before evaluating closure objectives and selecting the appropriate corrective action. The results of the field investigation will support closure and waste management decisions that will be presented in the Corrective Action Decision Document/Closure Report. The site will be investigated based on the data quality objectives (DQOs) developed on June 1, 2006, by representatives of the Nevada Division of Environmental Protection; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; Stoller-Navarro Joint Venture; and Bechtel Nevada. The DQO process was utilized to identify and define the type, amount, and quality of data needed to develop and evaluate closure for CAU 565. Appendix A provides a detailed discussion of the DQO methodology and the DQOs specific to this CAS. The scope of the corrective action investigation for CAU 565 includes the following activities: (1) Remove stored samples, shelves, and debris from the interior of Building 26-2106. (2) Perform field screening on stored samples, shelves, and debris. (3) Dispose of stored samples, shelves, and debris. (4) Collect samples of investigation-derived waste, as needed, for waste management purposes. (5) Conduct radiological surveys of Building 26-2106 in accordance with the requirements in the ''NV/YMP Radiological Control Manual'' to determine if there is residual radiological contamination that would prevent the release of the building for unrestricted use. This

  14. Corrective Action Investigation Plan for Corrective Action Unit 557: Spills and Tank Sites, Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Alfred Wickline

    2008-07-01

    Corrective Action Unit (CAU) 557 is located in Areas 1, 3, 6, and 25 of the Nevada Test Site, which is approximately 65 miles northwest of Las Vegas, Nevada, and is comprised of the four corrective action sites (CASs) listed below: • 01-25-02, Fuel Spill • 03-02-02, Area 3 Subdock UST • 06-99-10, Tar Spills • 25-25-18, Train Maintenance Bldg 3901 Spill Site These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation before evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on April 3, 2008, by representatives of the Nevada Division of Environmental Protection (NDEP); U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office; Stoller-Navarro Joint Venture; and National Security Technologies, LLC. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 557. Appendix A provides a detailed discussion of the DQO methodology and the DQOs specific to each CAS. The scope of the corrective action investigation for CAU 557 includes the following activities: • Move surface debris and/or materials, as needed, to facilitate sampling. • Conduct radiological survey at CAS 25-25-18. • Perform field screening. • Collect and submit environmental samples for laboratory analysis to determine whether contaminants of concern are present. • If contaminants of concern are present, collect additional step

  15. Corrective Action Decision Document/Closure Report for Corrective Action Unit 371: Johnnie Boy Crater and Pin Stripe Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews

    2010-07-01

    This Corrective Action Decision Document/Closure Report has been prepared for Corrective Action Unit 371, Johnnie Boy Crater and Pin Stripe, located within Areas 11 and 18 at the Nevada Test Site, Nevada, in accordance with the Federal Facility Agreement and Consent Order (FFACO). Corrective Action Unit (CAU) 371 comprises two corrective action sites (CASs): • 11-23-05, Pin Stripe Contamination Area • 18-45-01, U-18j-2 Crater (Johnnie Boy) The purpose of this Corrective Action Decision Document/Closure Report is to provide justification and documentation supporting the recommendation that no further corrective action is needed for CAU 371 based on the implementation of corrective actions. The corrective action of closure in place with administrative controls was implemented at both CASs. Corrective action investigation (CAI) activities were performed from January 8, 2009, through February 16, 2010, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 371: Johnnie Boy Crater and Pin Stripe. The approach for the CAI was divided into two facets: investigation of the primary release of radionuclides and investigation of other releases (migration in washes and chemical releases). The purpose of the CAI was to fulfill data needs as defined during the data quality objective (DQO) process. The CAU 371 dataset of investigation results was evaluated based on the data quality indicator parameters. This evaluation demonstrated the dataset is acceptable for use in fulfilling the DQO data needs. Analytes detected during the CAI were evaluated against final action levels (FALs) established in this document. Radiological doses exceeding the FAL of 25 millirem per year were not found to be present in the surface soil. However, it was assumed that radionuclides are present in subsurface media within the Johnnie Boy crater and the fissure at Pin Stripe. Due to the assumption of radiological dose exceeding the FAL, corrective actions were undertaken

  16. Corrective Action Investigation Plan for Corrective Action Unit 528: Polychlorinated Biphenyls Contamination, Nevada Test Site, Nevada, Rev. 0

    SciTech Connect

    U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office

    2003-05-08

    This Corrective Action Investigation Plan contains the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office's approach to collect the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 528, Polychlorinated Biphenyls Contamination (PCBs), Nevada Test Site (NTS), Nevada, under the Federal Facility Agreement and Consent Order. Located in the southwestern portion of Area 25 on the NTS in Jackass Flats (adjacent to Test Cell C [TCC]), CAU 528 consists of Corrective Action Site 25-27-03, Polychlorinated Biphenyls Surface Contamination. Test Cell C was built to support the Nuclear Rocket Development Station (operational between 1959 and 1973) activities including conducting ground tests and static firings of nuclear engine reactors. Although CAU 528 was not considered as a direct potential source of PCBs and petroleum contamination, two potential sources of contamination have nevertheless been identified from an unknown source in concentrations that could potentially pose an unacceptable risk to human health and/or the environment. This CAU's close proximity to TCC prompted Shaw to collect surface soil samples, which have indicated the presence of PCBs extending throughout the area to the north, east, south, and even to the edge of the western boundary. Based on this information, more extensive field investigation activities are being planned, the results of which are to be used to support a defensible evaluation of corrective action alternatives in the corrective action decision document.

  17. Corrective Action Decision Document/Closure Report for Corrective Action Unit 263: Area 25 Building 4839 Leachfield, Nevada Test Site, Nevada

    SciTech Connect

    1999-10-01

    This Corrective Action Decision Document/Closure Report (CADD/CR) has been prepared for Corrective Action Unit (CAU) 263, Area 25 Building 4839 Leachfield, in accordance with the Federal Facility Agreement and Consent Order. Corrective Action Unit 263 is located in the southwestern part of the Nevada Test Site in Nevada and includes one Corrective Action Site (CAS), CAS 25-05-04 Leachfield. This CADD/CR identifies and rationalizes the U.S. Department of Energy, Nevada Operations Office's (DOE/NV's) recommendation that no corrective action for CAU 263 is necessary. The Corrective Action Decision Document and Closure Report have been combined into one report because sample data collected during the April 1999 corrective action investigation (CAI) disclosed no evidence of contamination at the site. The purpose of the CAI was to identify the presence and the vertical and lateral extent of contaminants of potential concern (COPCs), specifically volatile organic compounds (VOCs) and semivola tile organic compounds (SVOCs) such as 1,4-dichlorobenzene and p-isopropyl toluene. The subsequent investigation included direct-push environmental soil samples from within the leachfield using a Geoprobe{reg_sign} unit; field screening of soil samples for radiological constituents and VOCs; submittal of environmental and quality control samples for testing for total VOCs, total SVOCs, and gamma spectrometry; and collection of soil samples from both the liquid phase and the underlying sludge of the septic tank contents. The CAI activities determined that: (1) all total VOC and total SVOC results were below the preliminary action levels outlined in the Corrective Action Investigation Plan (CAIP), and (2) radiological results were not distinguishable from background concentrations identified in the CAIP. Therefore, the DOE/NV recommended that no corrective action was required at CAU 263. No use restrictions were required to be placed on the CAU because the investigation showed no

  18. Magnesium, Silicon, and Oxygen Isotopic Consequences of CAI Evaporation and Inversion for Primordial Melt Compositions

    NASA Astrophysics Data System (ADS)

    Young, E. D.; Shahar, A.

    2012-03-01

    We show how realistic activity-composition relationships in CMAS melts can be used to invert silicon- and magnesium-isotope ratios for evaporation histories of CAIs. Results suggest igneous CAIs were indeed condensates from a solar gas.

  19. Investigations to the Antibacterial Mechanism of Action of Kendomycin

    PubMed Central

    A. Elnakady, Yasser; Chatterjee, Indranil; Bischoff, Markus; Rohde, Manfred; Josten, Michaele; Sahl, Hans-Georg; Herrmann, Mathias; Müller, Rolf

    2016-01-01

    Purpose The emergence of bacteria that are resistant to many currently used drugs emphasizes the need to discover and develop new antibiotics that are effective against such multi-resistant strains. Kendomycin is a novel polyketide that has a unique quinone methide ansa structure and various biological properties. This compound exhibits strong antibacterial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Despite the promise of kendomycinin in several therapeutic areas, its mode of action has yet to be identified. Methods In this study, we used a multidisciplinary approach to gain insight into the antibacterial mechanism of this compound. Results The antibacterial activity of kendomycin appears to be bacteriostatic rather than bactericidal. Kendomycin inhibited the growth of the MRSA strain COL at a low concentration (MIC of 5 μg/mL). Proteomic analysis and gene transcription profiling of kendomycin-treated cells indicated that this compound affected the regulation of numerous proteins and genes involved in central metabolic pathways, such as the tricarboxylic acid (TCA) cycle (SdhA) and gluconeogenesis (PckA and GapB), cell wall biosynthesis and cell division (FtsA, FtsZ, and MurAA), capsule production (Cap5A and Cap5C), bacterial programmed cell death (LrgA and CidA), the cellular stress response (ClpB, ClpC, ClpP, GroEL, DnaK, and GrpE), and oxidative stress (AhpC and KatA). Electron microscopy revealed that kendomycin strongly affected septum formation during cell division. Most kendomycin-treated cells displayed incomplete septa with abnormal morphology. Conclusions Kendomycin might directly or indirectly affect the cell division machinery, protein stability, and programmed cell death in S. aureus. Additional studies are still needed to obtain deeper insight into the mode of action of kendomycin. PMID:26795276

  20. Corrective action investigation plan for Corrective Action Unit 340, Pesticide Release Sites, Nevada Test Site, Nye County, Nevada

    SciTech Connect

    1998-01-01

    This Correction Action Investigation Plan (CAIP) has been developed in accordance with the Federal Facility Agreement and Consent Order (FFACO) that was agreed to by the US Department of Energy, Nevada Operations Office (DOE/NV); the State of Nevada Division of Environmental Protection (NDEP); and the US Department of Defense. As required by the FFACO (1996), this document provides or references all of the specific information for planning investigation activities associated with three Corrective Action Sites (CASs) located at the Nevada Test Site (NTS). These CASs are collectively known as Corrective Action Unit (CAU) 340, Pesticide Release Sites. According to the FFACO, CASs are sites that may require corrective action(s) and may include solid waste management units or individual disposal or release sites. These sites are CAS 23-21-01, Area 23 Quonset Hut 800 (Q800) Pesticide Release Ditch; CAS 23-18-03, Area 23 Skid Huts Pesticide Storage; and CAS 15-18-02, Area 15 Quonset Hut 15-11 Pesticide Storage (Q15-11). The purpose of this CAIP for CAU 340 is to direct and guide the investigation for the evaluation of the nature and extent of pesticides, herbicides, and other contaminants of potential concern (COPCs) that were stored, mixed, and/or disposed of at each of the CASs.

  1. Corrective Action Investigation Plan for Corrective Action Unit 562: Waste Systems Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Alfred Wickline

    2009-04-01

    Corrective Action Unit 562 is located in Areas 2, 23, and 25 of the Nevada Test Site, which is approximately 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 562 is comprised of the 13 corrective action sites (CASs) listed below: • 02-26-11, Lead Shot • 02-44-02, Paint Spills and French Drain • 02-59-01, Septic System • 02-60-01, Concrete Drain • 02-60-02, French Drain • 02-60-03, Steam Cleaning Drain • 02-60-04, French Drain • 02-60-05, French Drain • 02-60-06, French Drain • 02-60-07, French Drain • 23-60-01, Mud Trap Drain and Outfall • 23-99-06, Grease Trap • 25-60-04, Building 3123 Outfalls These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation before evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on December 11, 2008, by representatives of the Nevada Division of Environmental Protection; U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office; Stoller-Navarro Joint Venture; and National Security Technologies, LLC. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 562. Appendix A provides a detailed discussion of the DQO methodology and the DQOs specific to each CAS. The scope of the corrective action investigation for CAU 562 includes the following activities: • Move surface debris and/or materials, as needed, to facilitate sampling.

  2. CAI for the Developmentally Handicapped: Nine Years of Progress.

    ERIC Educational Resources Information Center

    Hallworth, H. J.; Brebner, Ann

    Initiated nine years ago by the University of Calgary Faculty of Education Computer Applications Unit in cooperation with the nearby Vocational and Rehabilitation Research Institute (VRRI), this project uses computer assisted instruction (CAI) to teach social and vocational skills to developmentally handicapped young adults, many of whom also have…

  3. Conjunctival mucin deficiency in complete androgen insensitivity syndrome (CAIS).

    PubMed

    Mantelli, Flavio; Moretti, Costanzo; Micera, Alessandra; Bonini, Stefano

    2007-06-01

    Sex steroid hormones are essential for a healthy ocular surface and the androgen receptor impairment found in patients with complete androgen insensitivity syndrome (CAIS) has been described to cause meibomian gland dysfunction and functional dry eye for lipid tear film layer instability. However, it has not been reported if the mucous layer is also affected. A 37-year-old CAIS patient with persistent symptoms of dry eye underwent ophthalmological examination and was evaluated for qualitative and quantitative tear function tests and conjunctival cytology. Samples obtained from the conjunctival epithelium were stained for histology and immunohistochemistry and compared with three age-matched female controls. Western blot and relative real-time RT-PCR for MUC1 and MUC5AC were also performed on these samples. Immunohistochemistry, Western blot and relative real-time RT-PCR showed a decrease in the expression of MUC1 and MUC5AC in CAIS. Changes in the tear film mucous layer were accompanied by a reduction in the tear film break up time test. This is the first report describing mucous layer alteration associated with androgen receptor impairment. Decreased mucin levels contribute in explaining the tear film instability in CAIS and should be considered an additional cause of dry eye in sex steroid hormone pathology.

  4. An Intelligent CAI Monitor and Generative Tutor. Interim Report.

    ERIC Educational Resources Information Center

    Koffman, Elliot B.; And Others

    Design techniques for generative computer-assisted-instructional (CAI) systems are described in this report. These are systems capable of generating problems for students and of deriving and monitoring solutions; problem difficulty, instructional pace, and depth of monitoring are all individually tailored and parts of the solution algorithms can…

  5. Introductory CAI Dialogue in Differential Calculus for Freshman Physics

    ERIC Educational Resources Information Center

    Kalman, C. S.; And Others

    1974-01-01

    A project on computer based dialogue for freshmen is described and evaluated. The dialogue utilizes a CAI language written in Fortran that allows a designer to easily write and edit questions at his own desk without the use of a terminal. (Author/DT)

  6. CAI: Overcoming Attitude Barriers of Prospective Primary Teachers. Final Report.

    ERIC Educational Resources Information Center

    Kockler, Lois H.

    During each of two school quarters, approximately 60 college students enrolled in a mathematics course were randomly assigned to an experimental group or a control group. The control group received instruction by the lecture method only; the experimental group received the same instruction, except that six computer-assisted instruction (CAI) units…

  7. CAISYS-8- A CAI Language Developed For A Minicomputer.

    ERIC Educational Resources Information Center

    Holm, Cheryl; And Others

    The University of Texas Medical Branch developed a minicomputer-based computer-assisted instruction (CAI) system which employed a teacher oriented software package called CAISYS-8, consisting of a highly modularized teaching compiler and operating system. CAISYS-8 used instructional quanta which generalized the flow of information to and from the…

  8. A Comparison of Student Option Versus Program Controlled CAI Training.

    ERIC Educational Resources Information Center

    McCann, Patrick H.; And Others

    A research study compared two methods for individualizing computer-assisted instruction (CAI) training and evaluated the effect of providing a lesson narrative before training. A 2x2 factorial design was used with 96 Navy trainees in the Basic Electricity/Electronics School. The two pretraining conditions were: 1) a narrative overview read before…

  9. Corrective Action Investigation Plan for Corrective Action Unit 335: Area 6 Injection Well and Drain Pit, Nevada Test Site, Nevada

    SciTech Connect

    DOE /NV

    2000-12-01

    This Corrective Action Investigation Plan contains the U.S. Department of Energy, Nevada Operations Office's approach to collect the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 335, Area 6 Injection Well and Drain Pit, under the Federal Facility Agreement and Consent Order. Corrective Action Unit 335 consists of three Corrective Action Sites (CASs). The CAU is located in the Well 3 Yard in Area 6 at the Nevada Test Site. Historical records indicate that the Drain Pit (CAS 06-23-03) received effluent from truck-washing; the Drums/Oil Waste/Spill (CAS 06-20-01) consisted of four 55-gallon drums containing material removed from the Cased Hole; and the Cased Hole (CAS 06-20-02) was used for disposal of used motor oil, wastewater, and debris. These drums were transported to the Area 5 Hazardous Waste Accumulation Site in July 1991; therefore, they are no longer on site and further investigation or remediation efforts are not required. Consequently, CAS 06-20-01 will be closed with no further action and details of this decision will be described in the Closure Report for this CAU. Any spills that may have been associated with this CAS will be investigated and addressed under CAS 06-20-02. Field investigation efforts will be focused on the two remaining CASs. The scope of the investigation will center around identifying any contaminants of potential concern (COPCs) and, if present, determining the vertical and lateral extent of contamination. The COPCs for the Drain Pit include: total volatile/ semivolatile organic compounds, total petroleum hydrocarbons (gasoline-and diesel-range organics), ethylene glycol monobutyl ether, polychlorinated biphenyls, total Resource Conservation and Recovery Act metals, and radionuclides. The COPCs for the Cased Hole include: total volatile/ semivolatile organic compounds, total petroleum hydrocarbons (diesel-range organics only), and total Resource Conservation an d

  10. 19 CFR 206.54 - Investigations with respect to extension of action.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... INVESTIGATIONS INVESTIGATIONS RELATING TO GLOBAL AND BILATERAL SAFEGUARD ACTIONS, MARKET DISRUPTION, TRADE...) Limited disclosure of certain confidential business information under administrative protective order... available to an authorized applicant under administrative protective order all confidential...

  11. Distribution and Origin of 36Cl In Allende CAIs

    SciTech Connect

    Matzel, J P; Jacobsen, B; Hutcheon, I D; Krot, A N; Nagashima, K; Yin, Q; Ramon, E C; Weber, P; Wasserburg, G J

    2009-12-11

    The abundance of short-lived radionuclides (SLRs) in early solar system materials provide key information about their nucleosynthetic origin and can constrain the timing of early solar system events. Excesses of {sup 36}S ({sup 36}S*) correlated with {sup 35}Cl/{sup 34}S ratios provide direct evidence for in situ decay of {sup 36}Cl ({tau}{sub 1/2} {approx} 0.3 Ma) and have been reported in sodalite (Na{sub 8}Al{sub 6}Si{sub 6}O{sub 24}Cl{sub 2}) and wadalite (Ca{sub 6}Al{sub 5}Si{sub 2}O{sub 16}Cl{sub 3}) in CAIs and chondrules from the Allende and Ningqiang CV carbonaceous chondrites. While previous studies demonstrate unequivocally that {sup 36}Cl was extant in the early solar system, no consensus on the origin or initial abundance of {sup 36}Cl has emerged. Understanding the origin of {sup 36}Cl, as well as the reported variation in the initial {sup 36}Cl/{sup 35}Cl ratio, requires addressing when, where and how chlorine was incorporated into CAIs and chondrules. These factors are key to distinguishing between stellar nucleosynthesis or energetic particle irradiation for the origin of {sup 36}Cl. Wadalite is a chlorine-rich secondary mineral with structural and chemical affinities to grossular. The high chlorine ({approx}12 wt%) and very low sulfur content (<<0.01 wt%) make wadalite ideal for studies of the {sup 36}Cl-{sup 36}S system. Wadalite is present in Allende CAIs exclusively in the interior regions either in veins crosscutting melilite or in zones between melilite and anorthite associated with intergrowths of grossular, monticellite, and wollastonite. Wadalite and sodalite most likely resulted from open-system alteration of primary minerals with a chlorine-rich fluid phase. We recently reported large {sup 36}S* correlated with {sup 35}Cl/{sup 34}S in wadalite in Allende Type B CAI AJEF, yielding a ({sup 36}Cl/{sup 35}Cl){sub 0} ratio of (1.7 {+-} 0.3) x 10{sup -5}. This value is the highest reported {sup 36}Cl/{sup 35}Cl ratio and is {approx}5 times

  12. Effectiveness of CAI Package on Achievement in Physics of IX Standard Students

    ERIC Educational Resources Information Center

    Maheswari, I. Uma; Ramakrishnan, N.

    2015-01-01

    The present study is an experimental one in nature, to find out the effectiveness of CAI package on in Physics of IX std. students. For this purpose a CAI package was developed and validated. The validated CAI package formed an independent variable of this study. The dependent variable is students' achievements in physics content. In order to find…

  13. Harvard University Computer-Aided Instruction (CAI) Laboratory. Technical Report Number 6.

    ERIC Educational Resources Information Center

    Stolurow, Lawrence M.; Peterson, Theodore I.

    This report is a detailed description of the Harvard CAI Laboratory, including its history, organization, functions, staffing, programs and support. Discussed are materials relating to CAI in general, such as psychological research, modes of instruction, advantages and implementation of CAI. Reviewed also are specific projects of this facility. A…

  14. Corrective Action Decision Document/Closure Report for Corrective Action Unit 190: Contaminated Waste Sites, Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Alfred Wickline

    2008-03-01

    This Corrective Action Decision Document/Closure Report has been prepared for Corrective Action Unit (CAU) 190, Contaminated Waste Sites, Nevada Test Site, Nevada, in accordance with the Federal Facility Agreement and Consent Order that was agreed to by the State of Nevada; U.S. Department of Energy, Environmental Management; U.S. Department of Defense; and DOE, Legacy Management (1996, as amended January 2007). Corrective Action Unit 190 is comprised of the following four corrective action sites (CASs): • 11-02-01, Underground Centrifuge • 11-02-02, Drain Lines and Outfall • 11-59-01, Tweezer Facility Septic System • 14-23-01, LTU-6 Test Area The purpose of this Corrective Action Decision Document/Closure Report is to provide justification and documentation supporting the recommendation for closure of CAU 190 with no further corrective action. To achieve this, corrective action investigation (CAI) activities were performed from March 21 through June 26, 2007. All CAI activities were conducted as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 190: Contaminated Waste Sites, Nevada Test Site, Nevada (NNSA/NSO, 2006). The purpose of the CAI was to fulfill the following data needs as defined during the data quality objective process: • Determine whether contaminants of concern (COCs) are present. • If COCs are present, determine their nature and extent. • Provide sufficient information and data to complete appropriate corrective actions. The CAU 190 dataset from the investigation results was evaluated based on the data quality indicator parameters. This evaluation demonstrated the quality and acceptability of the dataset for use in fulfilling the data quality objective data needs.

  15. Corrective Action Decision Document for Corrective Action Unit 568. Area 3 Plutonium Dispersion Sites, Nevada National Security Site, Nevada Revision 0

    SciTech Connect

    Matthews, Patrick

    2015-08-01

    The purpose of this Corrective Action Decision Document is to identify and provide the rationale for the recommendation of corrective action alternatives (CAAs) for the 14 CASs within CAU 568. Corrective action investigation (CAI) activities were performed from April 2014 through May 2015, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 568: Area 3 Plutonium Dispersion Sites, Nevada National Security Site, Nevada; and in accordance with the Soils Activity Quality Assurance Plan, which establishes requirements, technical planning, and general quality practices. The purpose of the CAI was to fulfill data needs as defined during the DQO process. The CAU 568 dataset of investigation results was evaluated based on a data quality assessment. This assessment demonstrated that the dataset is complete and acceptable for use in fulfilling the DQO data needs. Based on the evaluation of analytical data from the CAI, review of future and current operations at the 14 CASs, and the detailed and comparative analysis of the potential CAAs, the following corrective actions are recommended for CAU 568: • No further action is the preferred corrective action for CASs 03-23-17, 03-23-22, 03-23-26. • Closure in place is the preferred corrective action for CAS 03-23-19; 03-45-01; the SE DCBs at CASs 03-23-20, 03-23-23, 03-23-31, 03-23-32, 03-23-33, and 03-23-34; and the Pascal-BHCA at CAS 03-23-31. • Clean closure is the preferred corrective action for CASs 03-08-04, 03-23-30, and 03-26-04; and the four well head covers at CASs 03-23-20, 03-23-23, 03-23-31, and 03-23-33.

  16. Corrective Action Investigation Plan for Corrective Action Unit 543: Liquid Disposal Units, Nevada Test Site, Nevada: Revision 0

    SciTech Connect

    U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office

    2004-05-03

    The general purpose of this Corrective Action Investigation Plan is to ensure that adequate data are collected to provide sufficient and reliable information to identify, evaluate, and select technically viable corrective action alternatives (CAAs) for Corrective Action Unit (CAU) 543: Liquid Disposal Units, Nevada Test Site (NTS), Nevada. Located in Areas 6 and 15 on the NTS, CAU 543 is comprised of a total of seven corrective action sites (CASs), one in Area 6 and six in Area 15. The CAS in Area 6 consists of a Decontamination Facility and its components which are associated with decontamination of equipment, vehicles, and materials related to nuclear testing. The six CASs in Area 15 are located at the U.S. Environmental Protection Agency Farm and are related to waste disposal activities at the farm. Sources of possible contamination at Area 6 include potentially contaminated process waste effluent discharged through a process waste system, a sanitary waste stream generated within buildings of the Decon Facility, and radiologically contaminated materials stored within a portion of the facility yard. At Area 15, sources of potential contamination are associated with the dairy operations and the animal tests and experiments involving radionuclide uptake. Identified contaminants of potential concern include volatile organic compounds, semivolatile organic compounds, petroleum hydrocarbons, pesticides, herbicides, polychlorinated biphenyls, metals, and radionuclides. Three corrective action closure alternatives - No Further Action, Close in Place, or Clean Closure - will be recommended for CAU 543 based on an evaluation of all the data quality objective-related data. Field work will be conducted following approval of the plan. The results of the field investigation will support a defensible evaluation of CAAs that will be presented in the Corrective Action Decision Document.

  17. Disabling Conditions: Investigating Instructional Leadership Teams in Action

    ERIC Educational Resources Information Center

    Weiner, Jennie Miles

    2014-01-01

    This study investigated why and how principals selected members for their instructional leadership team (ILT) and how this selection criteria and process may have impacted team members' understandings of, and behaviors on, the team. Qualitative methods, specifically interviews and observations, were used to explore team members'…

  18. Corrective Action Investigation Plan for Corrective Action Unit 321: Area 22 Weather Station Fuel Storage, Nevada Test Site, Nevada

    SciTech Connect

    DOE /NV

    1999-01-28

    This Corrective Action Investigation Plan (CAIP) has been developed in accordance with the Federal Facility Agreement and Consent Order (FFACO) that was agreed to by the US Department of Energy, Nevada Operations Office (DOE/NV); the State of Nevada Division of Environmental Protection (NDEP); and the US Department of Defense (FFACO, 1996). The CAIP is a document that provides or references all of the specific information for investigation activities associated with Corrective Action Units (CAUs) or Corrective Action Sites (CASs). According to the FFACO (1996), CASs are sites potentially requiring corrective action(s) and may include solid waste management units or individual disposal or release sites. A CAU consists of one or more CASs grouped together based on geography, technical similarity, or agency responsibility for the purpose of determining corrective actions. This CAIP contains the environmental sample collection objectives and the criteria for conducting site investigation activities at the CAU 321 Area 22 Weather Station Fuel Storage, CAS 22-99-05 Fuel Storage Area. For purposes of this discussion, this site will be referred to as either CAU 321 or the Fuel Storage Area. The Fuel Storage Area is located in Area 22 of the Nevada Test Site (NTS). The NTS is approximately 105 kilometers (km) (65 miles [mi]) northwest of Las Vegas, Nevada (Figure 1-1) (DOE/NV, 1996a). The Fuel Storage Area (Figure 1-2) was used to store fuel and other petroleum products necessary for motorized operations at the historic Camp Desert Rock facility which was operational from 1951 to 1958 at the Nevada Test Site, Nevada. The site was dismantled after 1958 (DOE/NV, 1996a).

  19. Corrective Action Investigation Plan for Corrective Action Unit 486: Double Tracks RADSAFE Area Nellis Air Force Range, Nevada

    SciTech Connect

    IT Las Vegas

    1998-10-15

    This Corrective Action Investigation Plan (CAIP) has been developed in accordance with the Federal Facility Agreement and Consent Order (FFACO) that was agreed to by the US Department of Energy, Nevada Operations Office (DOE/NV); the State of Nevada Division of Environmental Protection (NDEP); and the US Department of Defense (FFACO, 1996). The CAIP is a document that provides or references all of the specific information for investigation activities associated with Corrective Action Units (CAUs) or Corrective Action Sites (CASs). According to the FFACO, CASs are sites potentially requiring corrective action(s) and may include solid waste management units or individual disposal or release sites (FFACO, 1996). Corrective Action Units consist of one or more CASs grouped together based on geography, technical similarity, or agency responsibility for the purpose of determining corrective actions. This CAIP contains the environmental sample collection objectives and the criteria for conducting site investigation activities at CAU 486, the Double Tracks Radiological Safety (RADSAFE) Area (DTRSA) which is located on the Nellis Air Force Range 71North (N), west of the Tonopah Test Range (TTR). The TTR, included in the Nellis Air Force Range Complex, is approximately 255 kilometers (km) (140 miles [mi]) northwest of Las Vegas, Nevada (Figure 1-1). Corrective Action Unit 486 is comprised of CAS 71-23-001-71DT consisting of two areas of concern referred to as the vehicle decontamination area and the animal burial pit. The DTRSA is located on the west side of the Cactus Range approximately 8 km (5 mi) southwest of the Cactus Spring gate at the intersection of the Cactus Spring Road and the Double Tracks Control Point Road (Figure 1-2). The DTRSA was used during May 1963 to decontaminate vehicles, equipment, personnel, and animals from the Double Tracks test. The DTRSA is one of three areas identified as a potential location for the disposal of radioactively contaminated

  20. Corrective Action Investigation Plan for Corrective Action Unit 409: Other Waste Sites, Tonopah Test Range, Nevada (Rev. 0)

    SciTech Connect

    DOE /NV

    2000-10-05

    This Corrective Action Investigation Plan contains the U.S. Department of Energy, Nevada Operations Office's approach to collect the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 409 under the Federal Facility Agreement and Consent Order. Corrective Action Unit 409 consists of three Corrective Action Sites (CASs): TA-53-001-TAB2, Septic Sludge Disposal Pit No.1; TA-53-002-TAB2, Septic Sludge Disposal Pit No.2; and RG-24-001-RGCR, Battery Dump Site. The Septic Sludge Disposal Pits are located near Bunker Two, close to Area 3, on the Tonopah Test Range. The Battery Dump Site is located at the abandoned Cactus Repeater Station on Cactus Peak. The Cactus Repeater Station was a remote, battery-powered, signal repeater station. The two Septic Sludge Disposal Pits were suspected to be used through the late 1980s as disposal sites for sludge from septic tanks located in Area 3. Based on site history collected to support the Data Quality Objectives process, contaminants of potential concern are the same for the disposal pits and include: volatile organic compounds (VOCs), semivolatile organic compounds, total petroleum hydrocarbons (TPHs) as gasoline- and diesel-range organics, polychlorinated biphenyls, Resource Conservation and Recovery Act metals, and radionuclides (including plutonium and depleted uranium). The Battery Dump Site consists of discarded lead-acid batteries and associated construction debris, placing the site in a Housekeeping Category and, consequently, no contaminants are expected to be encountered during the cleanup process. The corrective action the at this CAU will include collection of discarded batteries and construction debris at the Battery Dump Site for proper disposal and recycling, along with photographic documentation as the process progresses. The corrective action for the remaining CASs involves the collection of background radiological data through borings drilled at

  1. Corrective Action Investigation Plan for Corrective Action Unit 550: Smoky Contamination Area Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Grant Evenson

    2012-05-01

    Corrective Action Unit (CAU) 550 is located in Areas 7, 8, and 10 of the Nevada National Security Site, which is approximately 65 miles northwest of Las Vegas, Nevada. CAU 550, Smoky Contamination Area, comprises 19 corrective action sites (CASs). Based on process knowledge of the releases associated with the nuclear tests and radiological survey information about the location and shape of the resulting contamination plumes, it was determined that some of the CAS releases are co-located and will be investigated as study groups. This document describes the planned investigation of the following CASs (by study group): (1) Study Group 1, Atmospheric Test - CAS 08-23-04, Atmospheric Test Site T-2C; (2) Study Group 2, Safety Experiments - CAS 08-23-03, Atmospheric Test Site T-8B - CAS 08-23-06, Atmospheric Test Site T-8A - CAS 08-23-07, Atmospheric Test Site T-8C; (3) Study Group 3, Washes - Potential stormwater migration of contaminants from CASs; (4) Study Group 4, Debris - CAS 08-01-01, Storage Tank - CAS 08-22-05, Drum - CAS 08-22-07, Drum - CAS 08-22-08, Drums (3) - CAS 08-22-09, Drum - CAS 08-24-03, Battery - CAS 08-24-04, Battery - CAS 08-24-07, Batteries (3) - CAS 08-24-08, Batteries (3) - CAS 08-26-01, Lead Bricks (200) - CAS 10-22-17, Buckets (3) - CAS 10-22-18, Gas Block/Drum - CAS 10-22-19, Drum; Stains - CAS 10-22-20, Drum - CAS 10-24-10, Battery. These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for each study group. The results of the field investigation will support a defensible evaluation of viable CAAs that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed

  2. Corrective Action Investigation Plan for Corrective Action Unit 375: Area 30 Buggy Unit Craters, Nevada Test Site, Nevada

    SciTech Connect

    Patrick Matthews

    2010-03-01

    Corrective Action Unit (CAU) 375 is located in Areas 25 and 30 of the Nevada Test Site, which is approximately 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 375 comprises the two corrective action sites (CASs) listed below: • 25-23-22, Contaminated Soils Site • 30-45-01, U-30a, b, c, d, e Craters Existing information on the nature and extent of potential contamination present at the CAU 375 CASs is insufficient to evaluate and recommend corrective action alternatives (CAAs). This document details an investigation plan that will provide for the gathering of sufficient information to evaluate and recommend CAAs. Corrective Action Site 25-23-22 is composed of the releases associated with nuclear rocket testing at Test Cell A (TCA). Test Cell A was used to test and develop nuclear rocket motors as part of the Nuclear Rocket Development Station from its construction in 1958 until 1966, when rocket testing began being conducted at Test Cell C. The rocket motors were built with an unshielded nuclear reactor that produced as much as 1,100 kilowatts (at full power) to heat liquid hydrogen to 4,000 degrees Fahrenheit, at which time the expanded gases were focused out a nozzle to produce thrust. The fuel rods in the reactor were not clad and were designed to release fission fragments to the atmosphere, but due to vibrations and loss of cooling during some operational tests, fuel fragments in excess of planned releases became entrained in the exhaust and spread in the immediate surrounding area. Cleanup efforts have been undertaken at times to collect the fuel rod fragments and other contamination. Previous environmental investigations in the TCA area have resulted in the creation of a number of use restrictions. The industrial area of TCA is encompassed by a fence and is currently posted as a radioactive material area. Corrective Action Site 30-45-01 (releases associated with the Buggy Plowshare test) is located in Area 30 on Chukar Mesa. It was a

  3. Corrective Action Decision Document/Closure Report for Corrective Action Unit 557: Spills and Tank Sites, Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Alfred Wickline

    2009-05-01

    This Corrective Action Decision Document/Closure Report has been prepared for Corrective Action Unit (CAU) 557, Spills and Tank Sites, in Areas 1, 3, 6, and 25 of the Nevada Test Site, Nevada, in accordance with the Federal Facility Agreement and Consent Order. Corrective Action Unit 557 comprises the following corrective action sites (CASs): • 01-25-02, Fuel Spill • 03-02-02, Area 3 Subdock UST • 06-99-10, Tar Spills • 25-25-18, Train Maintenance Bldg 3901 Spill Site The purpose of this Corrective Action Decision Document/Closure Report is to identify and provide the justification and documentation that supports the recommendation for closure of the CAU 557 CASs with no further corrective action. To achieve this, a corrective action investigation (CAI) was conducted from May 5 through November 24, 2008. The CAI activities were performed as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 557: Spills and Tank Sites, Nevada Test Site, Nevada.

  4. Corrective Action Investigation Plan for Corrective Action Unit 487: Thunderwell Site, Tonopah Test Range, Nevada (Rev. No.: 0, January 2001)

    SciTech Connect

    DOE /NV

    2001-01-02

    This Corrective Action Investigation Plan contains the U.S. Department of Energy, Nevada Operations Office's (DOE/NV's) approach to collect the data necessary to evaluate corrective action alternatives (CAAs) appropriate for the closure of Corrective Action Unit (CAU) 487, Thunderwell Site, Tonopah Test Range (TTR), Nevada, under the Federal Facility Agreement and Consent Order. Corrective Action Unit 487 consists of a single Corrective Action Site (CAS), RG 26-001-RGRV, Thunderwell Site. The site is located in the northwest portion of the TTR, Nevada, approximately five miles northwest of the Area 3 Control Point and closest to the Cactus Flats broad basin. Historically, Sandia National Laboratories in New Mexico used CAU 487 in the early to mid-1960s for a series of high explosive tests detonated at the bottom of large cylindrical steel tubes. Historical photographs indicate that debris from these tests and subsequent operations may have been scattered and buried throughout the site. A March 2000 walk-over survey and a July 2000 geophysical survey indicated evidence of buried and surface debris in dirt mounds and areas throughout the site; however, a radiological drive-over survey also performed in July 2000 indicated that no radiological hazards were identified at this site. Based on site history, the scope of this plan is to resolve the problem statement identified during the Data Quality Objectives process that detonation activities at this CAU site may have resulted in the release of contaminants of concern into the surface/subsurface soil including total volatile and total semivolatile organic compounds, total Resource Conservation and Recovery Act metals, radionuclides, total petroleum hydrocarbons, and high explosives. Therefore, the scope of corrective action field investigation will involve excavation, drilling, and extensive soil sampling and analysis activities to determine the extent (if any) of both the lateral and vertical contamination and whether

  5. Corrective Action Decision Document for Corrective Action Unit 204: Storage Bunkers, Nevada Test Site, Nevada, Rev. No. 0

    SciTech Connect

    Robert Boehlecke

    2004-04-01

    The six bunkers included in CAU 204 were primarily used to monitor atmospheric testing or store munitions. The ''Corrective Action Investigation Plan (CAIP) for Corrective Action Unit 204: Storage Bunkers, Nevada Test Site, Nevada'' (NNSA/NV, 2002a) provides information relating to the history, planning, and scope of the investigation; therefore, it will not be repeated in this CADD. This CADD identifies potential corrective action alternatives and provides a rationale for the selection of a recommended corrective action alternative for each CAS within CAU 204. The evaluation of corrective action alternatives is based on process knowledge and the results of investigative activities conducted in accordance with the CAIP (NNSA/NV, 2002a) that was approved prior to the start of the Corrective Action Investigation (CAI). Record of Technical Change (ROTC) No. 1 to the CAIP (approval pending) documents changes to the preliminary action levels (PALs) agreed to by the Nevada Division of Environmental Protection (NDEP) and DOE, National Nuclear Security Administration Nevada Site Office (NNSA/NSO). This ROTC specifically discusses the radiological PALs and their application to the findings of the CAU 204 corrective action investigation. The scope of this CADD consists of the following: (1) Develop corrective action objectives; (2) Identify corrective action alternative screening criteria; (3) Develop corrective action alternatives; (4) Perform detailed and comparative evaluations of corrective action alternatives in relation to corrective action objectives and screening criteria; and (5) Recommend and justify a preferred corrective action alternative for each CAS within CAU 204.

  6. Corrective Action Investigation Plan for Corrective Action Unit 309: Area 12 Muckpiles, Nevada Test Site, Nevada, Rev. No. 0

    SciTech Connect

    Robert F. Boehlecke

    2004-12-01

    This Corrective Action Investigation Plan (CAIP) for Corrective Action Unit (CAU) 309, Area 12 Muckpiles, Nevada Test Site (NTS), Nevada, has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) that was agreed to by the State of Nevada, the U.S. Department of Energy, and the U.S. Department of Defense. The general purpose of the investigation is to ensure that adequate data are collected to provide sufficient and reliable information to identify, evaluate, and select technically viable corrective actions. Corrective Action Unit 309 is comprised of the following three corrective action sites (CASs) in Area 12 of the NTS: (1) CAS 12-06-09, Muckpile; (2) CAS 12-08-02, Contaminated Waste Dump (CWD); and (3) CAS 12-28-01, I-, J-, and K-Tunnel Debris. Corrective Action Site 12-06-09 consists of a muckpile and debris located on the hillside in front of the I-, J-, and K-Tunnels on the eastern slopes of Rainier Mesa in Area 12. The muckpile includes mining debris (muck) and debris generated during the excavation and construction of the I-, J-, and K-Tunnels. Corrective Action Site 12-08-02, CWD, consists of a muckpile and debris and is located on the hillside in front of the re-entry tunnel for K-Tunnel. For the purpose of this investigation CAS 12-28-01 is defined as debris ejected by containment failures during the Des Moines and Platte Tests and the associated contamination that is not covered in the two muckpile CASs. This site consists of debris scattered south of the I-, J-, and K-Tunnel muckpiles and extends down the hillside, across the valley, and onto the adjacent hillside to the south. In addition, the site will cover the potential contamination associated with ''ventings'' along the fault, fractures, and various boreholes on the mesa top and face. One conceptual site model was developed for all three CASs to address possible contamination migration pathways associated with CAU 309. The data quality objective (DQO

  7. An experimental study of the combustion characteristics in SCCI and CAI based on direct-injection gasoline engine

    SciTech Connect

    Lee, C.H.; Lee, K.H.

    2007-08-15

    Emissions remain a critical issue affecting engine design and operation, while energy conservation is becoming increasingly important. One approach to favorably address these issues is to achieve homogeneous charge combustion and stratified charge combustion at lower peak temperatures with a variable compression ratio, a variable intake temperature and a trapped rate of the EGR using NVO (negative valve overlap). This experiment was attempted to investigate the origins of these lower temperature auto-ignition phenomena with SCCI and CAI using gasoline fuel. In case of SCCI, the combustion and emission characteristics of gasoline-fueled stratified-charge compression ignition (SCCI) engine according to intake temperature and compression ratio was examined. We investigated the effects of air-fuel ratio, residual EGR rate and injection timing on the CAI combustion area. In addition, the effect of injection timing on combustion factors such as the start of combustion, its duration and its heat release rate was also investigated. (author)

  8. Corrective Action Investigation Plan for Corrective Action Unit 556: Dry Wells and Surface Release Points Nevada Test Site, Nevada (Draft), Revision 0

    SciTech Connect

    Grant Evenson

    2007-02-01

    Corrective Action Unit  (CAU) 556, Dry Wells and Surface Release Points, is located in Areas 6 and 25 of the Nevada Test Site, 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 556 is comprised of four corrective action sites (CASs) listed below: •06-20-04, National Cementers Dry Well •06-99-09, Birdwell Test Hole •25-60-03, E-MAD Stormwater Discharge and Piping •25-64-01, Vehicle Washdown and Drainage Pit These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation before evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document.

  9. Oxygen Isotope Measurements of a Rare Murchison Type A CAI and Its Rim

    NASA Technical Reports Server (NTRS)

    Matzel, J. E. P.; Simon, J. I.; Hutcheon, I. D.; Jacobsen, B.; Simon, S. B.; Grossman, L.

    2013-01-01

    Ca-, Al-rich inclusions (CAIs) from CV chondrites commonly show oxygen isotope heterogeneity among different mineral phases within individual inclusions reflecting the complex history of CAIs in both the solar nebula and/or parent bodies. The degree of isotopic exchange is typically mineral-specific, yielding O-16-rich spinel, hibonite and pyroxene and O-16-depleted melilite and anorthite. Recent work demonstrated large and systematic variations in oxygen isotope composition within the margin and Wark-Lovering rim of an Allende Type A CAI. These variations suggest that some CV CAIs formed from several oxygen reservoirs and may reflect transport between distinct regions of the solar nebula or varying gas composition near the proto-Sun. Oxygen isotope compositions of CAIs from other, less-altered chondrites show less intra-CAI variability and 16O-rich compositions. The record of intra-CAI oxygen isotope variability in CM chondrites, which commonly show evidence for low-temperature aqueous alteration, is less clear, in part because the most common CAIs found in CM chondrites are mineralogically simple (hibonite +/- spinel or spinel +/- pyroxene) and are composed of minerals less susceptible to O-isotopic exchange. No measurements of the oxygen isotope compositions of rims on CAIs in CM chondrites have been reported. Here, we present oxygen isotope data from a rare, Type A CAI from the Murchison meteorite, MUM-1. The data were collected from melilite, hibonite, perovskite and spinel in a traverse into the interior of the CAI and from pyroxene, melilite, anorthite, and spinel in the Wark-Lovering rim. Our objectives were to (1) document any evidence for intra-CAI oxygen isotope variability; (2) determine the isotopic composition of the rim minerals and compare their composition(s) to the CAI interior; and (3) compare the MUM-1 data to oxygen isotope zoning profiles measured from CAIs in other chondrites.

  10. Replacement textures in CAI and implications regarding planetary metamorphism

    NASA Technical Reports Server (NTRS)

    Meeker, G. P.; Wasserburg, G. J.; Armstrong, J. T.

    1983-01-01

    Formation by a secondary metamorphic event, rather than primary crystallization from a melt or a sequential nebular condensation, is indicated by textural and chemical features of five coarse grained, Ca- and Al-rich inclusions (CAI) from the Allende meteorite which contain embayed pyroxene surrounded by melilite. It is suggested that the most probable environment for a metamorphic process (requiring the addition of Ca derived from calcite or from the introduction of a fluid phase) is that of a small planetary body, rather than the solar nebula. These results are compatible with O isotopic heterogeneities within CAI, and offer a mechanism for the production of lower temperature alteration phases, together with the rim phases found in these inclusions.

  11. Naval Academy's CAI Project (Computer-Assisted Instruction Project). Final Project Report 1 July 1968 - 30 June 1971.

    ERIC Educational Resources Information Center

    Sandeford, W. H.; And Others

    Aimed at improving officer education through the use of modern technology, a two-pronged computer-assisted instruction (CAI) effort was initiated. CAI techniques and methods utilized in the dual projects (CAI-Teletype and CAI 1500) are discussed under three categories: computational, non-computational, and computer management of instruction.…

  12. Corrective Action Decision Document for Corrective Action Unit 562: Waste Systems Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Mark Krause

    2010-08-01

    This Corrective Action Decision Document (CADD) presents information supporting the selection of corrective action alternatives (CAAs) leading to the closure of Corrective Action Unit (CAU) 562, Waste Systems, in Areas 2, 23, and 25 of the Nevada Test Site, Nevada. This complies with the requirements of the Federal Facility Agreement and Consent Order (FFACO) that was agreed to by the State of Nevada; U.S. Department of Energy (DOE), Environmental Management; U.S. Department of Defense; and DOE, Legacy Management. Corrective Action Unit 562 comprises the following corrective action sites (CASs): • 02-26-11, Lead Shot • 02-44-02, Paint Spills and French Drain • 02-59-01, Septic System • 02-60-01, Concrete Drain • 02-60-02, French Drain • 02-60-03, Steam Cleaning Drain • 02-60-04, French Drain • 02-60-05, French Drain • 02-60-06, French Drain • 02-60-07, French Drain • 23-60-01, Mud Trap Drain and Outfall • 23-99-06, Grease Trap • 25-60-04, Building 3123 Outfalls The purpose of this CADD is to identify and provide the rationale for the recommendation of CAAs for the 13 CASs within CAU 562. Corrective action investigation (CAI) activities were performed from July 27, 2009, through May 12, 2010, as set forth in the CAU 562 Corrective Action Investigation Plan. The purpose of the CAI was to fulfill the following data needs as defined during the data quality objective (DQO) process: • Determine whether COCs are present. • If COCs are present, determine their nature and extent. • Provide sufficient information and data to complete appropriate corrective actions. A data quality assessment (DQA) performed on the CAU 562 data demonstrated the quality and acceptability of the data for use in fulfilling the DQO data needs. Analytes detected during the CAI were evaluated against appropriate final action levels (FALs) to identify the COCs for each CAS. The results of the CAI identified COCs at 10 of the 13 CASs in CAU 562, and thus corrective

  13. Corrective action investigation plan for CAU Number 453: Area 9 Landfill, Tonopah Test Range

    SciTech Connect

    1997-05-14

    This Corrective Action Investigation Plan (CAIP) contains the environmental sample collection objectives and criteria for conducting site investigation activities at the Area 9 Landfill, Corrective Action Unit (CAU) 453/Corrective Action (CAS) 09-55-001-0952, which is located at the Tonopah Test Range (TTR). The TTR, included in the Nellis Air Force Range, is approximately 255 kilometers (140 miles) northwest of Las Vegas, Nevada. The Area 9 Landfill is located northwest of Area 9 on the TTR. The landfill cells associated with CAU 453 were excavated to receive waste generated from the daily operations conducted at Area 9 and from range cleanup which occurred after test activities.

  14. Corrective Action Decision Document for Corrective Action Unit 417: Central Nevada Test Area Surface, Nevada Appendix D - Corrective Action Investigation Report, Central Nevada Test Area, CAU 417

    SciTech Connect

    U.S. Department of Energy, Nevada Operations office

    1999-04-02

    This Corrective Action Decision Document (CADD) identifies and rationalizes the U.S. Department of Energy, Nevada Operations Office's selection of a recommended corrective action alternative (CAA) appropriate to facilitate the closure of Corrective Action Unit (CAU) 417: Central Nevada Test Area Surface, Nevada, under the Federal Facility Agreement and Consent Order. Located in Hot Creek Valley in Nye County, Nevada, and consisting of three separate land withdrawal areas (UC-1, UC-3, and UC-4), CAU 417 is comprised of 34 corrective action sites (CASs) including 2 underground storage tanks, 5 septic systems, 8 shaker pad/cuttings disposal areas, 1 decontamination facility pit, 1 burn area, 1 scrap/trash dump, 1 outlier area, 8 housekeeping sites, and 16 mud pits. Four field events were conducted between September 1996 and June 1998 to complete a corrective action investigation indicating that the only contaminant of concern was total petroleum hydrocarbon (TPH) which was found in 18 of the CASs. A total of 1,028 samples were analyzed. During this investigation, a statistical approach was used to determine which depth intervals or layers inside individual mud pits and shaker pad areas were above the State action levels for the TPH. Other related field sampling activities (i.e., expedited site characterization methods, surface geophysical surveys, direct-push geophysical surveys, direct-push soil sampling, and rotosonic drilling located septic leachfields) were conducted in this four-phase investigation; however, no further contaminants of concern (COCs) were identified. During and after the investigation activities, several of the sites which had surface debris but no COCs were cleaned up as housekeeping sites, two septic tanks were closed in place, and two underground storage tanks were removed. The focus of this CADD was to identify CAAs which would promote the prevention or mitigation of human exposure to surface and subsurface soils with contaminant

  15. Silicon Isotopic Fractionation of CAI-like Vacuum Evaporation Residues

    SciTech Connect

    Knight, K; Kita, N; Mendybaev, R; Richter, F; Davis, A; Valley, J

    2009-06-18

    Calcium-, aluminum-rich inclusions (CAIs) are often enriched in the heavy isotopes of magnesium and silicon relative to bulk solar system materials. It is likely that these isotopic enrichments resulted from evaporative mass loss of magnesium and silicon from early solar system condensates while they were molten during one or more high-temperature reheating events. Quantitative interpretation of these enrichments requires laboratory determinations of the evaporation kinetics and associated isotopic fractionation effects for these elements. The experimental data for the kinetics of evaporation of magnesium and silicon and the evaporative isotopic fractionation of magnesium is reasonably complete for Type B CAI liquids (Richter et al., 2002, 2007a). However, the isotopic fractionation factor for silicon evaporating from such liquids has not been as extensively studied. Here we report new ion microprobe silicon isotopic measurements of residual glass from partial evaporation of Type B CAI liquids into vacuum. The silicon isotopic fractionation is reported as a kinetic fractionation factor, {alpha}{sub Si}, corresponding to the ratio of the silicon isotopic composition of the evaporation flux to that of the residual silicate liquid. For CAI-like melts, we find that {alpha}{sub Si} = 0.98985 {+-} 0.00044 (2{sigma}) for {sup 29}Si/{sup 28}Si with no resolvable variation with temperature over the temperature range of the experiments, 1600-1900 C. This value is different from what has been reported for evaporation of liquid Mg{sub 2}SiO{sub 4} (Davis et al., 1990) and of a melt with CI chondritic proportions of the major elements (Wang et al., 2001). There appears to be some compositional control on {alpha}{sub Si}, whereas no compositional effects have been reported for {alpha}{sub Mg}. We use the values of {alpha}Si and {alpha}Mg, to calculate the chemical compositions of the unevaporated precursors of a number of isotopically fractionated CAIs from CV chondrites whose

  16. Corrective Action Decision Document/Closure Report for Corrective Action Unit 511: Waste Dumps (Piles and Debris) Nevada Test Site, Nevada, Rev. No.: 0

    SciTech Connect

    Pastor, Laura

    2005-12-01

    This Corrective Action Decision Document/Closure Report has been prepared for Corrective Action Unit (CAU) 511, Waste Dumps (Piles & Debris). The CAU is comprised of nine corrective action sites (CASs) located in Areas 3, 4, 6, 7, 18, and 19 of the Nevada Test Site, Nevada, in accordance with the ''Federal Facility Agreement and Consent Order'' (1996). Corrective Action Unit 511 is comprised of nine CASs: (1) 03-08-02, Waste Dump (Piles & Debris); (2) 03-99-11, Waste Dump (Piles); (3) 03-99-12, Waste Dump (Piles & Debris); (4) 04-99-04, Contaminated Trench/Berm; (5) 06-16-01, Waste Dump (Piles & Debris); (6) 06-17-02, Scattered Ordnance/Automatic Weapons Range; (7) 07-08-01, Contaminated Mound; (8) 18-99-10, Ammunition Dump; and (9) 19-19-03, Waste Dump (Piles & Debris). The purpose of this Corrective Action Decision Document/Closure Report is to provide justification and documentation supporting the recommendation for closure of CAU 511 with no further corrective action. To achieve this, corrective action investigation (CAI) and closure activities were performed from January 2005 through August 2005, as set forth in the ''Corrective Action Investigation Plan for Corrective Action Unit 511: Waste Dumps (Piles & Debris)'' (NNSA/NSO, 2004) and Record of Technical Change No. 1. The purpose of the CAI was to fulfill the following data needs as defined during the data quality objective process: (1) Determine whether contaminants of concern (COCs) are present. (2) If COCs are present, determine their nature and extent. (3) Provide sufficient information and data to complete appropriate corrective actions. The CAU 511 dataset from the investigation results was evaluated based on the data quality indicator parameters. This evaluation demonstrated the quality and acceptability of the dataset for use in fulfilling the data quality objective data needs. Analytes detected during the CAI were evaluated against appropriate preliminary action levels to identify the COCs for each

  17. Corrective Action Investigation Plan for Corrective Action Unit 219: Septic Systems and Injection Wells, Nevada Test Site, Nevada, Rev. No.: 0

    SciTech Connect

    David A. Strand

    2005-01-01

    The Corrective Action Investigation Plan for Corrective Action Unit 219, Septic Systems and Injection Wells, has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' (1996) that was agreed to by the State of Nevada, the U.S. Department of Energy, and the U.S. Department of Defense. The purpose of the investigation is to ensure that adequate data are collected to provide sufficient and reliable information to identify, evaluate, and select technically viable corrective actions. Corrective Action Unit 219 is located in Areas 3, 16, and 23 of the Nevada Test Site, which is 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 219 is comprised of the six Corrective Action Sites (CASs) listed below: (1) 03-11-01, Steam Pipes and Asbestos Tiles; (2) 16-04-01, Septic Tanks (3); (3) 16-04-02, Distribution Box; (4) 16-04-03, Sewer Pipes; (5) 23-20-01, DNA Motor Pool Sewage and Waste System; and (6) 23-20-02, Injection Well. These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation prior to evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document.

  18. Action!

    ERIC Educational Resources Information Center

    Senese, Joseph

    1998-01-01

    A small group of teachers at one Illinois high school is helping to effect and promote change. Through the Action Research Laboratory (ARL), teams of teachers conduct collaborative action research to improve classroom practices. Data from the first two years of the ARL indicate that teachers are eager to participate in, and have thrived in, their…

  19. Investigating a Potential Auxin-Related Mode of Hormetic/Inhibitory Action of the Phytotoxin Parthenin.

    PubMed

    Belz, Regina G

    2016-01-01

    Parthenin is a metabolite of Parthenium hysterophorus and is believed to contribute to the weed's invasiveness via allelopathy. Despite the potential of parthenin to suppress competitors, low doses stimulate plant growth. This biphasic action was hypothesized to be auxin-like and, therefore, an auxin-related mode of parthenin action was investigated using two approaches: joint action experiments with Lactuca sativa, and dose-response experiments with auxin/antiauxin-resistant Arabidopsis thaliana genotypes. The joint action approach comprised binary mixtures of subinhibitory doses of the auxin 3-indoleacetic acid (IAA) mixed with parthenin or one of three reference compounds [indole-3-butyric acid (IBA), 2,3,5-triiodobenzoic acid (TIBA), 2-(p-chlorophenoxy)-2-methylpropionic acid (PCIB)]. The reference compounds significantly interacted with IAA at all doses, but parthenin interacted only at low doses indicating that parthenin hormesis may be auxin-related, in contrast to its inhibitory action. The genetic approach investigated the response of four auxin/antiauxin-resistant mutants and a wildtype to parthenin or two reference compounds (IAA, PCIB). The responses of mutant plants to the reference compounds confirmed previous reports, but differed from the responses observed for parthenin. Parthenin stimulated and inhibited all mutants independent of resistance. This provided no indication for an auxin-related action of parthenin. Therefore, the hypothesis of an auxin-related inhibitory action of parthenin was rejected in two independent experimental approaches, while the hypothesis of an auxin-related stimulatory effect could not be rejected.

  20. A behavioral task for investigating action discovery, selection and switching: comparison between types of reinforcer

    PubMed Central

    Fisher, Simon D.; Gray, Jason P.; Black, Melony J.; Davies, Jennifer R.; Bednark, Jeffery G.; Redgrave, Peter; Franz, Elizabeth A.; Abraham, Wickliffe C.; Reynolds, John N. J.

    2014-01-01

    Action discovery and selection are critical cognitive processes that are understudied at the cellular and systems neuroscience levels. Presented here is a new rodent joystick task suitable to test these processes due to the range of action possibilities that can be learnt while performing the task. Rats learned to manipulate a joystick while progressing through task milestones that required increasing degrees of movement accuracy. In a switching phase designed to measure action discovery, rats were repeatedly required to discover new target positions to meet changing task demands. Behavior was compared using both food and electrical brain stimulation reward (BSR) of the substantia nigra as reinforcement. Rats reinforced with food and those with BSR performed similarly overall, although BSR-treated rats exhibited greater vigor in responding. In the switching phase, rats learnt new actions to adapt to changing task demands, reflecting action discovery processes. Because subjects are required to learn different goal-directed actions, this task could be employed in further investigations of the cellular mechanisms of action discovery and selection. Additionally, this task could be used to assess the behavioral flexibility impairments seen in conditions such as Parkinson's disease and obsessive-compulsive disorder. The versatility of the task will enable cross-species investigations of these impairments. PMID:25477795

  1. Investigating a Potential Auxin-Related Mode of Hormetic/Inhibitory Action of the Phytotoxin Parthenin.

    PubMed

    Belz, Regina G

    2016-01-01

    Parthenin is a metabolite of Parthenium hysterophorus and is believed to contribute to the weed's invasiveness via allelopathy. Despite the potential of parthenin to suppress competitors, low doses stimulate plant growth. This biphasic action was hypothesized to be auxin-like and, therefore, an auxin-related mode of parthenin action was investigated using two approaches: joint action experiments with Lactuca sativa, and dose-response experiments with auxin/antiauxin-resistant Arabidopsis thaliana genotypes. The joint action approach comprised binary mixtures of subinhibitory doses of the auxin 3-indoleacetic acid (IAA) mixed with parthenin or one of three reference compounds [indole-3-butyric acid (IBA), 2,3,5-triiodobenzoic acid (TIBA), 2-(p-chlorophenoxy)-2-methylpropionic acid (PCIB)]. The reference compounds significantly interacted with IAA at all doses, but parthenin interacted only at low doses indicating that parthenin hormesis may be auxin-related, in contrast to its inhibitory action. The genetic approach investigated the response of four auxin/antiauxin-resistant mutants and a wildtype to parthenin or two reference compounds (IAA, PCIB). The responses of mutant plants to the reference compounds confirmed previous reports, but differed from the responses observed for parthenin. Parthenin stimulated and inhibited all mutants independent of resistance. This provided no indication for an auxin-related action of parthenin. Therefore, the hypothesis of an auxin-related inhibitory action of parthenin was rejected in two independent experimental approaches, while the hypothesis of an auxin-related stimulatory effect could not be rejected. PMID:26686984

  2. Corrective Action Decision Document/Closure Report for Corrective Action Unit 546: Injection Well and Surface Releases Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Alfred Wickline

    2008-12-01

    This Corrective Action Decision Document/Closure Report has been prepared for Corrective Action Unit 546, Injection Well and Surface Releases, at the Nevada Test Site, Nevada, in accordance with the Federal Facility Agreement and Consent Order (FFACO, 1996; as amended February 2008). Corrective Action Unit (CAU) 546 is comprised of two corrective action sites (CASs): • 06-23-02, U-6a/Russet Testing Area • 09-20-01, Injection Well The purpose of this Corrective Action Decision Document/Closure Report is to provide justification and documentation supporting the recommendation for closure of CAU 546. To achieve this, corrective action investigation (CAI) activities were performed from May 5 through May 28, 2008, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 546: Injection Well and Surface Releases, Nevada Test Site, Nevada (NNSA/NSO, 2008). The purpose of the CAI was to fulfill the following data needs as defined during the data quality objective (DQO) process: • Determine whether a contaminant of concern is present at a given CAS. • Determine whether sufficient information is available to evaluate potential corrective action alternatives at each CAS. The CAU 546 dataset from the investigation results was evaluated based on the data quality indicator parameters. This evaluation demonstrated the quality and acceptability of the dataset for use in fulfilling the DQO data needs. Because DQO data needs were met, and corrective actions have been implemented, it has been determined that no further corrective action (based on risk to human receptors) is necessary for the CAU 546 CASs. The U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office provides the following recommendations: • No further corrective actions are needed for CAU 546 CASs. • No Corrective Action Plan is required. • A Notice of Completion to the U.S. Department of Energy, National Nuclear Security Administration Nevada Site

  3. Corrective Action Decision Document for Corrective Action Unit 145: Wells and Storage Holes, Nevada Test Site, Nevada, Rev. No.: 0, with ROTC No. 1 and Addendum

    SciTech Connect

    David Strand

    2006-04-01

    This Corrective Action Decision Document has been prepared for Corrective Action Unit (CAU) 145, Wells and Storage Holes in Area 3 of the Nevada Test Site, Nevada, in accordance with the ''Federal Facility Agreement and Consent Order'' (1996). Corrective Action Unit 145 is comprised of the following corrective action sites (CASs): (1) 03-20-01, Core Storage Holes; (2) 03-20-02, Decon Pad and Sump; (3) 03-20-04, Injection Wells; (4) 03-20-08, Injection Well; (5) 03-25-01, Oil Spills; and (6) 03-99-13, Drain and Injection Well. The purpose of this Corrective Action Decision Document is to identify and provide the rationale for the recommendation of a corrective action alternative for the six CASs within CAU 145. Corrective action investigation activities were performed from August 1, 2005, through November 8, 2005, as set forth in the CAU 145 Corrective Action Investigation Plan and Record of Technical Change No. 1. Analytes detected during the Corrective Action Investigation (CAI) were evaluated against appropriate final action levels to identify the contaminants of concern for each CAS. The results of the CAI identified contaminants of concern at one of the six CASs in CAU 145 and required the evaluation of corrective action alternatives. Assessment of the data generated from investigation activities conducted at CAU 145 revealed the following: CASs 03-20-01, 03-20-02, 03-20-04, 03-20-08, and 03-99-13 do not contain contamination; and CAS 03-25-01 has pentachlorophenol and arsenic contamination in the subsurface soils. Based on the evaluation of analytical data from the CAI, review of future and current operations at the six CASs, and the detailed and comparative analysis of the potential corrective action alternatives, the following corrective actions are recommended for CAU 145. No further action is the preferred corrective action for CASs 03-20-01, 03-20-02, 03-20-04, 03-20-08, and 03-99-13. Close in place is the preferred corrective action for CAS 03-25-01. The

  4. An experimental study of fuel injection strategies in CAI gasoline engine

    SciTech Connect

    Hunicz, J.; Kordos, P.

    2011-01-15

    Combustion of gasoline in a direct injection controlled auto-ignition (CAI) single-cylinder research engine was studied. CAI operation was achieved with the use of the negative valve overlap (NVO) technique and internal exhaust gas re-circulation (EGR). Experiments were performed at single injection and split injection, where some amount of fuel was injected close to top dead centre (TDC) during NVO interval, and the second injection was applied with variable timing. Additionally, combustion at variable fuel-rail pressure was examined. Investigation showed that at fuel injection into recompressed exhaust fuel reforming took place. This process was identified via an analysis of the exhaust-fuel mixture composition after NVO interval. It was found that at single fuel injection in NVO phase, its advance determined the heat release rate and auto-ignition timing, and had a strong influence on NO{sub X} emission. However, a delay of single injection to intake stroke resulted in deterioration of cycle-to-cycle variability. Application of split injection showed benefits of this strategy versus single injection. Examinations of different fuel mass split ratios and variable second injection timing resulted in further optimisation of mixture formation. At equal share of the fuel mass injected in the first injection during NVO and in the second injection at the beginning of compression, the lowest emission level and cyclic variability improvement were observed. (author)

  5. Corrective Action Investigation Plan for Corrective Action Unit 529: Area 25 Contaminated Materials, Nevada Test Site, Nevada, Rev. 0, Including Record of Technical Change No. 1

    SciTech Connect

    U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office

    2003-02-26

    This Corrective Action Investigation Plan contains the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office's approach to collect the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 529, Area 25 Contaminated Materials, Nevada Test Site (NTS), Nevada, under the Federal Facility Agreement and Consent Order. CAU 529 consists of one Corrective Action Site (25-23-17). For the purpose of this investigation, the Corrective Action Site has been divided into nine parcels based on the separate and distinct releases. A conceptual site model was developed for each parcel to address the translocation of contaminants from each release. The results of this investigation will be used to support a defensible evaluation of corrective action alternatives in the corrective action decision document.

  6. Corrective action investigation plan for Corrective Action Unit Number 427: Area 3 septic waste system numbers 2 and 6, Tonopah Test Range, Nevada

    SciTech Connect

    1997-09-19

    This Corrective Action Investigation Plan (CAIP) contains the environmental sample collection objectives and the criteria for conducting site investigation activities at the Area 3 Compound, specifically Corrective Action Unit (CAU) Number 427, which is located at the Tonopah Test Range (TTR). The TTR, included in the Nellis Air Force Range, is approximately 255 kilometers (140 miles) northwest of Las Vegas, Nevada. The Corrective Action Unit Work Plan, Tonopah Test Range, Nevada divides investigative activities at TTR into Source Groups. The Septic Tanks and Lagoons Group consists of seven CAUs. Corrective Action Unit Number 427 is one of three septic waste system CAUs in TTR Area 3. Corrective Action Unit Numbers 405 and 428 will be investigated at a future data. Corrective Action Unit Number 427 is comprised of Septic Waste Systems Number 2 and 6 with respective CAS Numbers 03-05-002-SW02 and 03-05-002-SW06.

  7. Corrective action investigation plan for Project Shoal Area CAU No. 416

    SciTech Connect

    1996-08-01

    This Corrective Action Investigation Plan (CAIP) is part of an ongoing US Department of Energy (DOE)-funded project for the investigation of Corrective Action Unit (CAU) No. 416, Project Shoal Area (PSA). Project Shoal was conducted to determine whether seismic waves produced by underground nuclear testing could be differentiated from naturally occurring earthquakes. The PSA site is located approximately 30 miles southeast of Fallon, Nevada, in the northern portion of Sand Springs Mountains in Churchill County. This CAIP will be implemented in accordance with the Federal Facility Agreement and Consent Order, the Industrial Sites Quality Assurance Project Plan, and all applicable Nevada Division of Environmental Protection policies and regulations.

  8. Corrective Action Investigation Plan: Roller Coaster Lagoons and North Disposal Trench, Tonopah Test Range, Revision 1

    SciTech Connect

    IT Corporation, Las Vegas, NV

    1996-06-27

    1.1 Purpose The purpose of this investigation is to collect data to confirm the presence or absence of contamination, evaluate the potential for contaminant migration, and select appropriate closure methods for these sites. The potential closure methods for these sites involve either clean closure, closure in place, or no further action. 1.2 Scope The scope of this investigation includes collecting surface and subsurface soil samples at the Roller Coaster Lagoons; and collecting surface soil samples at the North Disposal Trench and the small spill area associated with the Voluntary Cotiective Action (VCA) that was conducted in 1995.

  9. Willy: A prize noble Ur-Fremdling - Its history and implications for the formation of Fremdlinge and CAI

    NASA Technical Reports Server (NTRS)

    Armstrong, J. T.; El Goresy, A.; Wasserburg, G. J.

    1985-01-01

    The structure and composition of Willy, a 150-micron-diameter Fremdling in CAI 5241 from the Allende meteorite, are investigated using optical, secondary-electron, and electron-backscatter microscopy and electron-microprobe analysis. The results are presented in diagrams, maps, tables, graphs, and micrographs and compared with those for other Allende Fremdlinge. Willy is found to have a concentric-zone structure comprising a complex porous core of magnetite, metal, sulfide, scheelite, and other minor phases; a compact magnetite-apatite mantle; a thin (20 microns or less) reaction-assemblage zone; and a dense outer rim of fassaite with minor spinel. A multistage formation sequence involving changes in T and fO2 and preceding the introduction of Willy into the CAI (which itself preceded CAI spinel and silicate formation) is postulated, and it is inferred from the apparent lack of post-capture recrystallization that Willy has not been subjected to temperatures in excess of 600 C and may represent the precursor material for many other Fremdlinge.

  10. Coordinated Oxygen Isotopic and Petrologic Studies of CAIS Record Varying Composition of Protosolar

    NASA Technical Reports Server (NTRS)

    Simon, Justin I.; Matzel, J. E. P.; Simon, S. B.; Weber, P. K.; Grossman, L.; Ross, D. K.; Hutcheon, I. D.

    2012-01-01

    Ca-, Al-rich inclusions (CAIs) record the O-isotope composition of Solar nebular gas from which they grew [1]. High spatial resolution O-isotope measurements afforded by ion microprobe analysis across the rims and margin of CAIs reveal systematic variations in (Delta)O-17 and suggest formation from a diversity of nebular environments [2-4]. This heterogeneity has been explained by isotopic mixing between the O-16-rich Solar reservoir [6] and a second O-16-poor reservoir (probably nebular gas) with a "planetary-like" isotopic composition [e.g., 1, 6-7], but the mechanism and location(s) where these events occur within the protoplanetary disk remain uncertain. The orientation of large and systematic variations in (Delta)O-17 reported by [3] for a compact Type A CAI from the Efremovka reduced CV3 chondrite differs dramatically from reports by [4] of a similar CAI, A37 from the Allende oxidized CV3 chondrite. Both studies conclude that CAIs were exposed to distinct, nebular O-isotope reservoirs, implying the transfer of CAIs among different settings within the protoplanetary disk [4]. To test this hypothesis further and the extent of intra-CAI O-isotopic variation, a pristine compact Type A CAI, Ef-1 from Efremovka, and a Type B2 CAI, TS4 from Allende were studied. Our new results are equally intriguing because, collectively, O-isotopic zoning patterns in the CAIs indicate a progressive and cyclic record. The results imply that CAIs were commonly exposed to multiple environments of distinct gas during their formation. Numerical models help constrain conditions and duration of these events.

  11. Corrective Action Decision Document/Closure Report for Corrective Action Unit 106: Area 5, 11 Frenchman Flat Atmospheric Sites, Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews and Dawn Peterson

    2011-09-01

    Corrective Action Unit 106 comprises four corrective action sites (CASs): (1) 05-20-02, Evaporation Pond; (2) 05-23-05, Atmospheric Test Site - Able; (3) 05-45-04, 306 GZ Rad Contaminated Area; (4) 05-45-05, 307 GZ Rad Contaminated Area. The purpose of this CADD/CR is to provide justification and documentation supporting the recommendation that no further corrective action is needed for CAU 106 based on the implementation of corrective actions. The corrective action of clean closure was implemented at CASs 05-45-04 and 05-45-05, while no corrective action was necessary at CASs 05-20-02 and 05-23-05. Corrective action investigation (CAI) activities were performed from October 20, 2010, through June 1, 2011, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 106: Areas 5, 11 Frenchman Flat Atmospheric Sites. The approach for the CAI was divided into two facets: investigation of the primary release of radionuclides, and investigation of other releases (mechanical displacement and chemical releases). The purpose of the CAI was to fulfill data needs as defined during the data quality objective (DQO) process. The CAU 106 dataset of investigation results was evaluated based on a data quality assessment. This assessment demonstrated the dataset is complete and acceptable for use in fulfilling the DQO data needs. Investigation results were evaluated against final action levels (FALs) established in this document. A radiological dose FAL of 25 millirem per year was established based on the Industrial Area exposure scenario (2,250 hours of annual exposure). The only radiological dose exceeding the FAL was at CAS 05-45-05 and was associated with potential source material (PSM). It is also assumed that additional PSM in the form of depleted uranium (DU) and DU-contaminated debris at CASs 05-45-04 and 05-45-05 exceed the FAL. Therefore, corrective actions were undertaken at these CASs that consisted of removing PSM and collecting verification

  12. Investigating the Impact of Possession-Way of a Smartphone on Action Recognition.

    PubMed

    Kim, Zae Myung; Jeong, Young-Seob; Oh, Hyung Rai; Oh, Kyo-Joong; Lim, Chae-Gyun; Iraqi, Youssef; Choi, Ho-Jin

    2016-01-01

    For the past few decades, action recognition has been attracting many researchers due to its wide use in a variety of applications. Especially with the increasing number of smartphone users, many studies have been conducted using sensors within a smartphone. However, a lot of these studies assume that the users carry the device in specific ways such as by hand, in a pocket, in a bag, etc. This paper investigates the impact of providing an action recognition system with the information of the possession-way of a smartphone, and vice versa. The experimental dataset consists of five possession-ways (hand, backpack, upper-pocket, lower-pocket, and shoulder-bag) and two actions (walking and running) gathered by seven users separately. Various machine learning models including recurrent neural network architectures are employed to explore the relationship between the action recognition and the possession-way recognition. The experimental results show that the assumption of possession-ways of smartphones do affect the performance of action recognition, and vice versa. The results also reveal that a good performance is achieved when both actions and possession-ways are recognized simultaneously.

  13. Investigating the Impact of Possession-Way of a Smartphone on Action Recognition.

    PubMed

    Kim, Zae Myung; Jeong, Young-Seob; Oh, Hyung Rai; Oh, Kyo-Joong; Lim, Chae-Gyun; Iraqi, Youssef; Choi, Ho-Jin

    2016-01-01

    For the past few decades, action recognition has been attracting many researchers due to its wide use in a variety of applications. Especially with the increasing number of smartphone users, many studies have been conducted using sensors within a smartphone. However, a lot of these studies assume that the users carry the device in specific ways such as by hand, in a pocket, in a bag, etc. This paper investigates the impact of providing an action recognition system with the information of the possession-way of a smartphone, and vice versa. The experimental dataset consists of five possession-ways (hand, backpack, upper-pocket, lower-pocket, and shoulder-bag) and two actions (walking and running) gathered by seven users separately. Various machine learning models including recurrent neural network architectures are employed to explore the relationship between the action recognition and the possession-way recognition. The experimental results show that the assumption of possession-ways of smartphones do affect the performance of action recognition, and vice versa. The results also reveal that a good performance is achieved when both actions and possession-ways are recognized simultaneously. PMID:27271623

  14. Investigating the Impact of Possession-Way of a Smartphone on Action Recognition †

    PubMed Central

    Kim, Zae Myung; Jeong, Young-Seob; Oh, Hyung Rai; Oh, Kyo-Joong; Lim, Chae-Gyun; Iraqi, Youssef; Choi, Ho-Jin

    2016-01-01

    For the past few decades, action recognition has been attracting many researchers due to its wide use in a variety of applications. Especially with the increasing number of smartphone users, many studies have been conducted using sensors within a smartphone. However, a lot of these studies assume that the users carry the device in specific ways such as by hand, in a pocket, in a bag, etc. This paper investigates the impact of providing an action recognition system with the information of the possession-way of a smartphone, and vice versa. The experimental dataset consists of five possession-ways (hand, backpack, upper-pocket, lower-pocket, and shoulder-bag) and two actions (walking and running) gathered by seven users separately. Various machine learning models including recurrent neural network architectures are employed to explore the relationship between the action recognition and the possession-way recognition. The experimental results show that the assumption of possession-ways of smartphones do affect the performance of action recognition, and vice versa. The results also reveal that a good performance is achieved when both actions and possession-ways are recognized simultaneously. PMID:27271623

  15. Action Learning in Higher Education: An Investigation of Its Potential to Develop Professional Capability

    ERIC Educational Resources Information Center

    Lizzio, Alf; Wilson, Keithia

    2004-01-01

    This study investigated the extent to which a course, designed using peer and action learning principles to function as an 'on campus practicum', can develop the professional capabilities of students. As part of their formal coursework, third year behavioural science students, functioning as 'student consultants', entered into a…

  16. 29 CFR 801.20 - Adverse employment action under ongoing investigation exemption.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Restrictions on Polygraph Usage Under Exemptions § 801.20 Adverse employment action under ongoing investigation exemption... upon the analysis of a polygraph test chart or the refusal to take a polygraph test, without...

  17. 29 CFR 801.20 - Adverse employment action under ongoing investigation exemption.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Restrictions on Polygraph Usage Under Exemptions § 801.20 Adverse employment action under ongoing investigation exemption... upon the analysis of a polygraph test chart or the refusal to take a polygraph test, without...

  18. 29 CFR 801.20 - Adverse employment action under ongoing investigation exemption.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Restrictions on Polygraph Usage Under Exemptions § 801.20 Adverse employment action under ongoing investigation exemption... upon the analysis of a polygraph test chart or the refusal to take a polygraph test, without...

  19. 29 CFR 801.20 - Adverse employment action under ongoing investigation exemption.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Restrictions on Polygraph Usage Under Exemptions § 801.20 Adverse employment action under ongoing investigation exemption... upon the analysis of a polygraph test chart or the refusal to take a polygraph test, without...

  20. 29 CFR 801.20 - Adverse employment action under ongoing investigation exemption.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Restrictions on Polygraph Usage Under Exemptions § 801.20 Adverse employment action under ongoing investigation exemption... upon the analysis of a polygraph test chart or the refusal to take a polygraph test, without...

  1. The Effects of Issue Investigation and Action Training on Environmental Behavior in Seventh Grade Students.

    ERIC Educational Resources Information Center

    Ramsey, John M.; Hungerford, Harold

    1989-01-01

    This study reports the instructional effects of issue investigation and action training on the environmental behavior of middle school students. Discussed are the methodology including training and modules, the design of the study, instruments used, scoring protocols, and analysis of results. (Author/CW)

  2. A Study of the Qualities Teachers Recommend in STS Issues Investigation and Action Instructional Materials.

    ERIC Educational Resources Information Center

    Rubba, Peter A.; Wiesenmayer, Randall L.

    This study was part of a project to develop science and technology (STS) issue investigation and action materials with the potential for use across science and social studies classes at the secondary level. Special emphasis was given to learning teachers' perspectives on the development of a unit on the impact of pesticides on society. Seven areas…

  3. The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA

    SciTech Connect

    Kelly, R.; Bolitho, M; Higgins, D; Lu, W; Ng, W; Jeffrey, P; Rabinowitz, J; Semmelhack, M; Hughson, F; Bassler, B

    2009-01-01

    Vibrio cholerae, the bacterium that causes the disease cholera, controls virulence factor production and biofilm development in response to two extracellular quorum-sensing molecules, called autoinducers. The strongest autoinducer, called CAI-1 (for cholera autoinducer-1), was previously identified as (S)-3-hydroxytridecan-4-one. Biosynthesis of CAI-1 requires the enzyme CqsA. Here, we determine the CqsA reaction mechanism, identify the CqsA substrates as (S)-2-aminobutyrate and decanoyl coenzyme A, and demonstrate that the product of the reaction is 3-aminotridecan-4-one, dubbed amino-CAI-1. CqsA produces amino-CAI-1 by a pyridoxal phosphate-dependent acyl-CoA transferase reaction. Amino-CAI-1 is converted to CAI-1 in a subsequent step via a CqsA-independent mechanism. Consistent with this, we find cells release {ge}100 times more CAI-1 than amino-CAI-1. Nonetheless, V. cholerae responds to amino-CAI-1 as well as CAI-1, whereas other CAI-1 variants do not elicit a quorum-sensing response. Thus, both CAI-1 and amino-CAI-1 have potential as lead molecules in the development of an anticholera treatment.

  4. Audio-Tutorial and CAI Aids for Problem Solving in Introductory Chemistry

    ERIC Educational Resources Information Center

    Lower, Stephen K.

    1970-01-01

    Starting from a successful audio-tutorial program, the author initiated a computer assisted tutorial program in solving chemistry problems. Discusses the advantages of computer assisted instruction (CAI) over audiotapes and the advantages of both over conventional instructional methods. Presents a flow chart of a CAI program on a calorimetry…

  5. Knowledge-Based CAI: CINS for Individualized Curriculum Sequencing. Final Technical Report No. 290.

    ERIC Educational Resources Information Center

    Wescourt, Keith T.; And Others

    This report describes research on the Curriculum Information Network (CIN) paradigm for computer-assisted instruction (CAI) in technical subjects. The CIN concept was first conceived and implemented in the BASIC Instructional Program (BIP). The primary objective of CIN-based CAI and the BIP project has been to develop procedures for providing each…

  6. The Computer as a Socializing Agent: Some Socioaffective Outcomes of CAI.

    ERIC Educational Resources Information Center

    Hess, Robert D.; And Others

    The socializing role of computer-assisted instruction (CAI) was seen to be a positive one in this study. The students, predominantly Mexican-American, who experienced CAI, and other students, in a control group, who did not, liked the computer. They thought it gave the right answers and they respected it as having a vast array of information…

  7. A Study of Effectiveness of Computer Assisted Instruction (CAI) over Classroom Lecture (CRL) at ICS Level

    ERIC Educational Resources Information Center

    Kaousar, Tayyeba; Choudhry, Bushra Naoreen; Gujjar, Aijaz Ahmed

    2008-01-01

    This study was aimed to evaluate the effectiveness of CAI vs. classroom lecture for computer science at ICS level. The objectives were to compare the learning effects of two groups with classroom lecture and computer-assisted instruction studying the same curriculum and the effects of CAI and CRL in terms of cognitive development. Hypotheses of…

  8. The Graphics Terminal Display System; a Powerful General-Purpose CAI Package.

    ERIC Educational Resources Information Center

    Hornbeck, Frederick W., Brock, Lynn

    The Graphic Terminal Display System (GTDS) was created to support research and development in computer-assisted instruction (CAI). The system uses an IBM 360/50 computer and interfaces with a large-screen graphics display terminal, a random-access slide projector, and a speech synthesizer. An authoring language, GRAIL, was developed for CAI, and…

  9. Curricular and Computer System Compatibility of CAI Programs for Multi-University Use.

    ERIC Educational Resources Information Center

    Hall, Keith A.

    A brief introduction to developmental efforts in computer assisted instruction (CAI) at Pennsylvania State University is followed by a description of a program of mobile CAI facilities inaugurated in 1970 as part of the inservice continuing education program for teachers. The paper includes very brief descriptions of the graduate level courses…

  10. Distribution of vanadium and melting of opaque assemblages in Efremovka CAI's

    NASA Technical Reports Server (NTRS)

    Casanova, I.; Grossman, L.

    1993-01-01

    A petrographic and chemical study of compact Type A CAI's from the Efremovka CV3 chondrite strongly suggests that the opaque assemblages (OA's) that they contain were molten at temperatures below the CAI silicate solidus, and that the V-rich magnetite presently observed in association with OA's formed by in situ oxidation of their FeNi.

  11. Generative Computer Assisted Instruction: An Application of Artificial Intelligence to CAI.

    ERIC Educational Resources Information Center

    Koffman, Elliot B.

    Frame-oriented computer-assisted instruction (CAI) systems dominate the field, but these mechanized programed texts utilize the computational power of the computer to a minimal degree and are difficult to modify. Newer, generative CAI systems which are supplied with a knowledge of subject matter can generate their own problems and solutions, can…

  12. An Object-Oriented Architecture for a Web-Based CAI System.

    ERIC Educational Resources Information Center

    Nakabayashi, Kiyoshi; Hoshide, Takahide; Seshimo, Hitoshi; Fukuhara, Yoshimi

    This paper describes the design and implementation of an object-oriented World Wide Web-based CAI (Computer-Assisted Instruction) system. The goal of the design is to provide a flexible CAI/ITS (Intelligent Tutoring System) framework with full extendibility and reusability, as well as to exploit Web-based software technologies such as JAVA, ASP (a…

  13. A Multi-Media CAI Terminal Based upon a Microprocessor with Applications for the Handicapped.

    ERIC Educational Resources Information Center

    Brebner, Ann; Hallworth, H. J.

    The design of the CAI interface described is based on the microprocessor in order to meet three basic requirements for providing appropriate instruction to the developmentally handicapped: (1) portability, so that CAI can be taken into the customary learning environment; (2) reliability; and (3) flexibility, to permit use of new input and output…

  14. A Position Paper on CAI Research and Development. A Series Two Paper from ERIC at Stanford.

    ERIC Educational Resources Information Center

    Feldhusen, John H.; Lorton, Paul, Jr.

    After a critical review of the papers on Computer-Assisted Instruction (CAI) of several prominent educators, recommendations are proffered for CAI systems improvements prior to new research. These include replacing the typed message with an inexpensive cathode ray tube, developing the student interface as an efficient and pleasant carrel which…

  15. Computer-Aided Technical Training Using Electronic Equipment On-Line with the CAI System.

    ERIC Educational Resources Information Center

    Huggett, Geoffrey; And Others

    This report describes an experimental course in the operation and troubleshooting of a communications transceiver, the AN/URC-32, in which the transceiver is used as part of an instructional station in a CAI system. The transceiver and the CAI system are hard-wired together to form a single training system. The system is presently operating in the…

  16. Nebular History of the Allende FoB CAI SJ101

    NASA Astrophysics Data System (ADS)

    Petaev, M. I.; Jacobsen, S. B.

    2009-03-01

    We compare petrologic and chemical characteristics of a unique FoB CAI SJ101 with the results of thermodynamic modeling of condensation of its precursors in a system of solar composition and speculate about nebular formation history of this CAI.

  17. Corrective Action Investigation Plan for Corrective Action Unit 554: Area 23 Release Site, Nevada Test Site, Nevada, Rev. 0 with ROTC No. 1 and ROTC No. 2

    SciTech Connect

    Robert F. Boehlecke

    2004-10-01

    This Corrective Action Investigation Plan (CAIP) contains project-specific information for conducting site investigation activities at Corrective Action Unit (CAU) 554: Area 23 Release Site, Nevada Test Site, Nevada. Information presented in this CAIP includes facility descriptions, environmental sample collection objectives, and criteria for the selection and evaluation of environmental samples. Corrective Action Unit 554 is located in Area 23 of the Nevada Test Site, which is 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 554 is comprised of one Corrective Action Site (CAS), which is: 23-02-08, USTs 23-115-1, 2, 3/Spill 530-90-002. This site consists of soil contamination resulting from a fuel release from underground storage tanks (USTs). Corrective Action Site 23-02-08 is being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation prior to evaluating corrective action alternatives and selecting the appropriate corrective action for this CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document for CAU 554. Corrective Action Site 23-02-08 will be investigated based on the data quality objectives (DQOs) developed on July 15, 2004, by representatives of the Nevada Division of Environmental Protection; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; and contractor personnel. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 554. Appendix A provides a detailed discussion of the DQO methodology and the DQOs specific to CAS 23-02-08. The scope of the corrective action investigation

  18. INAA of CAIs from the Maralinga CK4 chondrite: Effects of parent body thermal metamorphism

    NASA Technical Reports Server (NTRS)

    Lindstrom, D. J.; Keller, L. P.; Martinez, R. R.

    1993-01-01

    Maralinga is an anomalous CK4 carbonaceous chondrite which contains numerous Ca-, Al-rich inclusions (CAI's) unlike the other members of the CK group. These CAI's are characterized by abundant green hercynitic spinel intergrown with plagioclase and high-Ca clinopyroxene, and a total lack of melilite. Instrumental Neutron Activation Analysis (INAA) was used to further characterize the meteorite, with special focus on the CAI's. High sensitivity INAA was done on eight sample disks about 100-150 microns in diameter obtained from a normal 30 micron thin section with a diamond microcoring device. The CAI's are enriched by 60-70X bulk meteorite values in Zn, suggesting that the substantial exchange of Fe for Mg that made the spinel in the CAI's hercynitic also allowed efficient scavenging of Zn from the rest of the meteorite during parent body thermal metamorphism. Less mobile elements appear to have maintained their initial heterogeneity.

  19. Aircraft accident investigation: the decision-making in initial action scenario.

    PubMed

    Barreto, Marcia M; Ribeiro, Selma L O

    2012-01-01

    In the complex aeronautical environment, the efforts in terms of operational safety involve the adoption of proactive and reactive measures. The process of investigation begins right after the occurrence of the aeronautical accident, through the initial action. Thus, it is in the crisis scenario, that the person responsible for the initial action makes decisions and gathers the necessary information for the subsequent phases of the investigation process. Within this scenario, which is a natural environment, researches have shown the fragility of rational models of decision making. The theoretical perspective of naturalistic decision making constitutes a breakthrough in the understanding of decision problems demanded by real world. The proposal of this study was to verify if the initial action, after the occurrence of an accident, and the decision-making strategies, used by the investigators responsible for this activity, are characteristic of the naturalistic decision making theoretical approach. To attend the proposed objective a descriptive research was undertaken with a sample of professionals that work in this activity. The data collected through individual interviews were analyzed and the results demonstrated that the initial action environment, which includes restricted time, dynamic conditions, the presence of multiple actors, stress and insufficient information is characteristic of the naturalistic decision making. They also demonstrated that, when the investigators make their decisions, they use their experience and the mental simulation, intuition, improvisation, metaphors and analogues cases, as strategies, all of them related to the naturalistic approach of decision making, in order to satisfy the needs of the situation and reach the objectives of the initial action in the accident scenario.

  20. Aircraft accident investigation: the decision-making in initial action scenario.

    PubMed

    Barreto, Marcia M; Ribeiro, Selma L O

    2012-01-01

    In the complex aeronautical environment, the efforts in terms of operational safety involve the adoption of proactive and reactive measures. The process of investigation begins right after the occurrence of the aeronautical accident, through the initial action. Thus, it is in the crisis scenario, that the person responsible for the initial action makes decisions and gathers the necessary information for the subsequent phases of the investigation process. Within this scenario, which is a natural environment, researches have shown the fragility of rational models of decision making. The theoretical perspective of naturalistic decision making constitutes a breakthrough in the understanding of decision problems demanded by real world. The proposal of this study was to verify if the initial action, after the occurrence of an accident, and the decision-making strategies, used by the investigators responsible for this activity, are characteristic of the naturalistic decision making theoretical approach. To attend the proposed objective a descriptive research was undertaken with a sample of professionals that work in this activity. The data collected through individual interviews were analyzed and the results demonstrated that the initial action environment, which includes restricted time, dynamic conditions, the presence of multiple actors, stress and insufficient information is characteristic of the naturalistic decision making. They also demonstrated that, when the investigators make their decisions, they use their experience and the mental simulation, intuition, improvisation, metaphors and analogues cases, as strategies, all of them related to the naturalistic approach of decision making, in order to satisfy the needs of the situation and reach the objectives of the initial action in the accident scenario. PMID:22317482

  1. Corrective action investigation plan for CAU No. 424: Area 3 Landfill Complex, Tonopah Test Range, Nevada

    SciTech Connect

    1997-04-01

    This Correction Action Investigation Plan contains the environmental sample collection objectives and the criteria for conducting site investigation activities at the Area 3 Landfill Complex, CAU No. 424, which is located at the Tonopah Test Range (TTR). The TTR, included in the Nellis Air Force Range, is approximately 255 kilometers (140 miles) northwest of Las Vegas, nevada. The CAU 424 is comprised of eight individual landfill sites that are located around and within the perimeter of the Area 3 Compound. Due to the unregulated disposal activities commonly associated with early landfill operations, an investigation will be conducted at each CAS to complete the following tasks: identify the presence and nature of possible contaminant migration from the landfills; determine the vertical and lateral extent of possible contaminant migration; ascertain the potential impact to human health and the environment; and provide sufficient information and data to develop and evaluate appropriate corrective action strategies for each CAS.

  2. Investigating the neural basis of cooperative joint action. An EEG hyperscanning study.

    PubMed

    Astolfi, L; Toppi, J; Vogel, P; Mattia, D; Babiloni, F; Ciaramidaro, A; Siniatchkin, M

    2014-01-01

    The aim of the present study is to investigate the neurophysiological basis of the cognitive functions underlying the execution of joint actions, by means of the recent technique called hyperscanning. Neuroelectrical hyperscanning is based on the simultaneous recording of brain activity from multiple subjects and includes the analysis of the functional relation between the brain activity of all the interacting individuals. We recorded simultaneous high density electroencephalography (hdEEG) from 16 pairs of subjects involved in a computerized joint action paradigm, with controlled levels of cooperation. Results of cortical connectivity analysis returned significant differences, in terms of inter-brain functional causal links, between the condition of cooperative joint action and a condition in which the subjects were told they were interacting with a PC, while actually interacting with another human subject. Such differences, described by selected brain connectivity indices, point toward an integration between the two subjects' brain activity in the cooperative condition, with respect to control conditions.

  3. Corrective Action Investigation Plan for Corrective Action Unit 371: Johnnie Boy Crater and Pin Stripe Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews

    2009-02-01

    Corrective Action Unit (CAU) 371 is located in Areas 11 and 18 of the Nevada Test Site, which is approximately 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 371 is comprised of the two corrective action sites (CASs) listed below: • 11-23-05, Pin Stripe Contamination Area • 18-45-01, U-18j-2 Crater (Johnnie Boy) These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation before evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on November 19, 2008, by representatives of the Nevada Division of Environmental Protection; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; Stoller-Navarro Joint Venture; and National Security Technologies, LLC. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 371. Appendix A provides a detailed discussion of the DQO methodology and the DQOs specific to each CAS. The scope of the corrective action investigation for CAU 371 includes the following activities: • Move surface debris and/or materials, as needed, to facilitate sampling. • Conduct radiological surveys. • Measure in situ external dose rates using thermoluminescent dosimeters or other dose measurement devices. • Collect and submit environmental samples for laboratory analysis to determine internal dose rates. • Combine internal and external dose rates to determine whether total

  4. Corrective Action Decision Document for Corrective Action Unit 366: Area 11 Plutonium Valley Dispersion Sites Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews

    2012-09-01

    CAU 366 comprises six corrective action sites (CASs): • 11-08-01, Contaminated Waste Dump #1 • 11-08-02, Contaminated Waste Dump #2 • 11-23-01, Radioactively Contaminated Area A • 11-23-02, Radioactively Contaminated Area B • 11-23-03, Radioactively Contaminated Area C • 11-23-04, Radioactively Contaminated Area D The purpose of this CADD is to identify and provide the rationale for the recommendation of corrective action alternatives (CAA) for the six CASs within CAU 366. Corrective action investigation (CAI) activities were performed from October 12, 2011, to May 14, 2012, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 366: Area 11 Plutonium Valley Dispersion Sites.

  5. Corrective Action Investigation Plan for Corrective Action Unit 568: Area 3 Plutonium Dispersion Sites Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Matthews, Patrick

    2014-01-01

    CAU 568 is a grouping of sites where there has been a suspected release of contamination associated with nuclear testing. This document describes the planned investigation of CAU 568, which comprises the following corrective action sites (CASs): • 03-23-17, S-3I Contamination Area • 03-23-19, T-3U Contamination Area • 03-23-20, Otero Contamination Area • 03-23-22, Platypus Contamination Area • 03-23-23, San Juan Contamination Area • 03-23-26, Shrew/Wolverine Contamination Area These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable CAAs that will be presented in the investigation report.

  6. Microcalorimetric investigation of the toxic action of berberine on Tetrahymena thermophila BF(5).

    PubMed

    Kong, Weijun; Li, Zulun; Xiao, Xiaohe; Zhao, Yanling

    2010-10-01

    Tetrahymena thermophila (T. thermophila) BF(5) produces heat through growth and metabolism. By microcalorimetry, the power-time curves of the metabolism of T. thermophila BF(5) at 28 °C were measured and some quantitative parameters were obtained from these curves. Then the action of berberine on this microbe was investigated. Furthermore, the minimum inhibitory concentration (MIC) of berberine against T. thermophila BF(5) growth was obtained by tube dilution method. Berberine of different concentrations had various actions on T. thermophila BF(5) growth: a low concentration (25 μg/ml) of berberine began to inhibit the growth of T. thermophila BF(5) and a high concentration (450 μg/ml) of berberine completely inhibited T. thermophila BF(5) growth. The toxic action of berberine could also be expressed as half-inhibitory concentration IC(50), i.e., 50% effective in this inhibition. The value of IC(50) was 175.60 μg/ml, while the MIC of this compound against T. thermophila BF(5) was 20.76 mg/ml. Berberine has strong toxic action on T. thermophila BF(5) growth. The microcalorimetric method for the assay of toxic action is quantitative, inexpensive and versatile.

  7. Corrective Action Investigation Plan for Corrective Action Unit 516: Septic Systems and Discharge Points, Nevada Test Site, Nevada, Rev. 0, Including Record of Technical Change No. 1

    SciTech Connect

    2003-04-28

    This Corrective Action Investigation Plan (CAIP) contains the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Sites Office's (NNSA/NSO's) approach to collect the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 516, Septic Systems and Discharge Points, Nevada Test Site (NTS), Nevada, under the Federal Facility Agreement and Consent Order. CAU 516 consists of six Corrective Action Sites: 03-59-01, Building 3C-36 Septic System; 03-59-02, Building 3C-45 Septic System; 06-51-01, Sump Piping, 06-51-02, Clay Pipe and Debris; 06-51-03, Clean Out Box and Piping; and 22-19-04, Vehicle Decontamination Area. Located in Areas 3, 6, and 22 of the NTS, CAU 516 is being investigated because disposed waste may be present without appropriate controls, and hazardous and/or radioactive constituents may be present or migrating at concentrations and locations that could potentially pose a threat to human health and the environment. Existing information and process knowledge on the expected nature and extent of contamination of CAU 516 are insufficient to select preferred corrective action alternatives; therefore, additional information will be obtained by conducting a corrective action investigation. The results of this field investigation will support a defensible evaluation of corrective action alternatives in the corrective action decision document. Record of Technical Change No. 1 is dated 3/2004.

  8. Corrective action investigation plan for Central Nevada Test Area, CAU No. 417

    SciTech Connect

    1997-04-01

    This Corrective Action Investigation Plan (CAIP) is part of a US Department of Energy (DOE)-funded environmental investigation of the Central Nevada Test Area (CNTA). This CAIP addresses the surface investigation and characterization of 15 identified Corrective Action Sites (CASs). In addition, several other areas of the CNTA project area have surface expressions that may warrant investigation. These suspect areas will be characterized, if necessary, in subsequent CAIPs or addendums to this CAIP prepared to address these sites. This CAIP addresses only the 15 identified CASs as shown in Table 2-1 that are associated with the drilling and construction of a number of testing wells designed as part of an underground nuclear testing program. The purpose of the wells at the time of construction was to provide subsurface access for the emplacement, testing, and post detonation evaluations of underground nuclear devices. If contamination is found at any of the 15-surface CASs, the extent of contamination will be determined in order to develop an appropriate corrective action.

  9. Students of Action? A Comparative Investigation of Secondary Science and Social Studies Students' Action Repertoires in a Land Use Context

    ERIC Educational Resources Information Center

    Kumler, Lori M.

    2011-01-01

    Environmental education (EE) and social studies education share an interest in behavioral outcomes. This study compares behavioral outcomes--including both self-reported knowledge of actions and reported actions taken--in the context of a land use curriculum enacted in secondary science versus social studies classes with 500 students and nine…

  10. Corrective Action Decision Document/Closure Report for Corrective Action Unit 274: Septic Systems, Nevada Test Site, Nevada, Rev. No.: 0

    SciTech Connect

    Grant Evenson

    2006-09-01

    This Corrective Action Decision Document/Closure Report has been prepared for Corrective Action Unit 274, Septic Systems, Nevada Test Site (NTS), Nevada in accordance with the ''Federal Facility Agreement and Consent Order'' (1996). Corrective Action Unit (CAU) 274 is comprised of five corrective action sites (CASs): (1) CAS 03-02-01, WX-6 ETS Building Septic System; (2) CAS 06-02-01, Cesspool; (3) CAS 09-01-01, Spill Site; (4) CAS 09-05-01, Leaching Pit; and (5) CAS 20-05-01, Septic System. The purpose of this Corrective Action Decision Document/Closure Report is to provide justification and documentation supporting the closure of CAU 274 with no further corrective action. To achieve this, corrective action investigation (CAI) activities were performed from November 14 through December 17, 2005 as set forth in the CAU 274 Corrective Action Investigation Plan. The purpose of the CAI was to fulfill the following data needs as defined during the data quality objective (DQO) process: (1) Determine whether contaminants of concern (COCs) are present. (2) If contaminants of concern are present, determine their nature and extent. (3) Provide sufficient information and data to complete appropriate corrective actions. The CAU 274 dataset from the investigation results was evaluated based on the data quality indicator parameters. This evaluation demonstrated the quality and acceptability of the dataset for use in fulfilling the DQO data needs. Analytes detected during the CAI were evaluated against final action levels (FALs) established in this document. No analytes were detected at concentrations exceeding the FALs. No COCs have been released to the soil at CAU 274, and corrective action is not required. Therefore, the DQO data needs were met, and it was determined that no corrective action based on risk to human receptors is necessary for the site. All FALs were calculated using the industrial site worker scenario except for benzo(a)pyrene, which was calculated based on

  11. Corrective Action Investigation Plan for Corrective Action Unit 204: Storage Bunkers, Nevada Test Site, Nevada (December 2002, Revision No.: 0), Including Record of Technical Change No. 1

    SciTech Connect

    NNSA /NSO

    2002-12-12

    The Corrective Action Investigation Plan contains the U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office's approach to collect the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 204 under the Federal Facility Agreement and Consent Order. Corrective Action Unit 204 is located on the Nevada Test Site approximately 65 miles northwest of Las Vegas, Nevada. This CAU is comprised of six Corrective Action Sites (CASs) which include: 01-34-01, Underground Instrument House Bunker; 02-34-01, Instrument Bunker; 03-34-01, Underground Bunker; 05-18-02, Chemical Explosives Storage; 05-33-01, Kay Blockhouse; 05-99-02, Explosive Storage Bunker. Based on site history, process knowledge, and previous field efforts, contaminants of potential concern for Corrective Action Unit 204 collectively include radionuclides, beryllium, high explosives, lead, polychlorinated biphenyls, total petroleum hydrocarbons, silver, warfarin, and zinc phosphide. The primary question for the investigation is: ''Are existing data sufficient to evaluate appropriate corrective actions?'' To address this question, resolution of two decision statements is required. Decision I is to ''Define the nature of contamination'' by identifying any contamination above preliminary action levels (PALs); Decision II is to ''Determine the extent of contamination identified above PALs. If PALs are not exceeded, the investigation is completed. If PALs are exceeded, then Decision II must be resolved. In addition, data will be obtained to support waste management decisions. Field activities will include radiological land area surveys, geophysical surveys to identify any subsurface metallic and nonmetallic debris, field screening for applicable contaminants of potential concern, collection and analysis of surface and subsurface soil samples from biased locations, and step-out sampling to define the extent of

  12. Addendum to the Corrective Action Investigation Plan for Corrective Action Unit 321: Area 22 Weather Station Fuel Storage, Nevada Test Site, Nevada (Rev. 0, November 2000)

    SciTech Connect

    DOE /NV

    2000-11-03

    This addendum to the Corrective Action Investigation Plan (CAIP) contains the U.S. Department of Energy, Nevada Operations Office's approach to determine the extent of contamination existing at Corrective Action Unit (CAU) 321. This addendum was required when the extent of contamination exceeded the estimate in the original Corrective Action Decision Document (CADD). Located in Area 22 on the Nevada Test Site, Corrective Action Unit 321, Weather Station Fuel Storage, consists of Corrective Action Site 22-99-05, Fuel Storage Area, was used to store fuel and other petroleum products necessary for motorized operations at the historic Camp Desert Rock facility. This facility was operational from 1951 to 1958 and dismantled after 1958. Based on site history and earlier investigation activities at CAU 321, the contaminant of potential concern (COPC) was previously identified as total petroleum hydrocarbons (diesel-range organics). The scope of this corrective action investigation for the Fuel Storage Area will include the selection of biased sample locations to determine the vertical and lateral extent of contamination, collection of soil samples using rotary sonic drilling techniques, and the utilization of field-screening methods to accurately determine the extent of COPC contamination. The results of this field investigation will support a defensible evaluation of corrective action alternatives and be included in the revised CADD.

  13. Corrective Action Decision Document for Corrective Action Unit 127: Areas 25 and 26 Storage Tanks, Nevada Test Site, Nevada: Revision 0

    SciTech Connect

    U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office

    2003-09-26

    This Corrective Action Decision Document identifies and rationalizes the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office's selection of recommended corrective action alternatives (CAAs) appropriate to facilitate the closure of Corrective Action Unit (CAU) 127: Areas 25 and 26 Storage Tanks, Nevada Test Site, Nevada, under the Federal Facility Agreement and Consent Order. Corrective Action Unit 127 consists of twelve corrective action sites (CASs). Corrective action investigation (CAI) activities were performed from February 24, 2003, through May 2, 2003, with additional sampling conducted on June 6, 2003, June 9, 2003, and June 24, 2003. Analytes detected during these investigation activities were evaluated against preliminary action levels to identify contaminants of concern (COCs) for each CAS, resulting in the determination that only two of the CASs did not have COCs exceeding regulatory levels. Based on the evaluation of analytical data from the CAI, review of future and current operations in Areas 25 and 26 of the Nevada Test Site, and the detailed and comparative analysis of the potential CAAs, the following alternatives were developed for consideration: (1) No Further Action is the preferred corrective action for the two CASs (25-02-13, 26-02-01) identified with no COCs; (2) Clean Closure is the preferred corrective action for eight of the CASs (25-01-05, 25-23-11, 25-12-01, 25-01-06, 26-01-01, 26-01-02, 26-99-01, 26-23-01); and (3) Closure in Place is the preferred corrective action for the remaining two CASs (25-01-07, 25-02-02). These three alternatives were judged to meet all requirements for the technical components evaluated. Additionally, these alternatives meet all applicable state and federal regulations for closure of the sites at CAU 127 and will reduce potential future exposure pathways to the contaminated media.

  14. Corrective Action Decision Document/Closure Report for Corrective Action Unit 234: Mud Pits, Cellars, and Mud Spills Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Grant Evenson

    2008-05-01

    This Corrective Action Decision Document/Closure Report has been prepared for Corrective Action Unit (CAU) 234, Mud Pits, Cellars, and Mud Spills, located in Areas 2, 3, 4, 12, and 15 at the Nevada Test Site, Nevada, in accordance with the Federal Facility Agreement and Consent Order (FFACO, 1996; as amended February 2008). Corrective Action Unit 234 is comprised of the following 12 corrective action sites: •02-09-48, Area 2 Mud Plant #1 •02-09-49, Area 2 Mud Plant #2 •02-99-05, Mud Spill •03-09-02, Mud Dump Trenches •04-44-02, Mud Spill •04-99-02, Mud Spill •12-09-01, Mud Pit •12-09-04, Mud Pit •12-09-08, Mud Pit •12-30-14, Cellar •12-99-07, Mud Dump •15-09-01, Mud Pit The purpose of this Corrective Action Decision Document/Closure Report is to provide justification and documentation supporting the recommendation for closure of CAU 234 with no further corrective action. To achieve this, corrective action investigation (CAI) activities were performed as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 234: Mud Pits, Cellars, and Mud Spills (NNSA/NSO, 2007). The purpose of the CAI was to fulfill the following data needs as defined during the data quality objective (DQO) process: •Determine whether contaminants of concern are present. •If contaminants of concern are present, determine their extent. •Provide sufficient information and data to complete appropriate corrective actions. The CAU 234 dataset from the investigation results was evaluated based on the data quality indicator parameters. This evaluation demonstrated the quality and acceptability of the dataset for use in fulfilling the DQO data needs.

  15. Corrective Action Decision Document/Closure Report for Corrective Action Unit 367: Area 10 Sedan, Ess and Uncle Unit Craters Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews

    2011-06-01

    Corrective Action Unit 367 comprises four corrective action sites (CASs): • 10-09-03, Mud Pit • 10-45-01, U-10h Crater (Sedan) • 10-45-02, Ess Crater Site • 10-45-03, Uncle Crater Site The purpose of this Corrective Action Decision Document/Closure Report is to provide justification and documentation of the corrective actions and site closure activities implemented at CAU 367. A corrective action of closure in place with use restrictions was completed at each of the three crater CASs (10-45-01, 10-45-02, and 10-45-03); corrective actions were not required at CAS 10-09-03. In addition, a limited soil removal corrective action was conducted at the location of a potential source material release. Based on completion of these correction actions, no additional corrective action is required at CAU 367, and site closure is considered complete. Corrective action investigation (CAI) activities were performed from February 2010 through March 2011, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 367: Area 10 Sedan, Ess and Uncle Unit Craters, Nevada Test Site, Nevada. The approach for the CAI was divided into two facets: investigation of the primary release of radionuclides, and investigation of non-test or other releases (e.g., migration in washes and potential source material). Based on the proximity of the Uncle, Ess, and Sedan craters, the impact of the Sedan test on the fallout deposited from the two earlier tests, and aerial radiological surveys, the CAU 367 investigation was designed to study the releases from the three crater CASs as one combined release (primary release). Corrective Action Site 10-09-03, Mud Pit, consists of two mud pits identified at CAU 367. The mud pits are considered non-test releases or other releases and were investigated independent of the three crater CASs. The purpose of the CAI was to fulfill data needs as defined during the data quality objective (DQO) process. The CAU 367 dataset of

  16. Corrective Action Decision Document/ Corrective Action Plan for Corrective Action Unit 443: Central Nevada Test Area-Subsurface Central Nevada Test Area, Nevada, Rev. No. 0

    SciTech Connect

    Susan Evans

    2004-11-01

    This Corrective Action Decision Document/Corrective Action Plan (CADD/CAP) has been prepared for the subsurface at the Central Nevada Test Area (CNTA) Corrective Action Unit (CAU) 443, CNTA - Subsurface, Nevada, in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996). CAU 443 is located in Hot Creek Valley in Nye County, Nevada, north of U.S. Highway 6, about 48 kilometers north of Warm Springs, Nevada. The CADD/CAP combines the decision document (CADD) with the corrective action plan (CAP) and provides or references the specific information necessary to recommend corrective actions for the UC-1 Cavity (Corrective Action Site 58-57-001) at CAU 443, as provided in the FFACO. The purpose of the CADD portion of the document (Section 1.0 to Section 4.0) is to identify and provide a rationale for the selection of a recommended corrective action alternative for the subsurface at CNTA. To achieve this, the following tasks were required: (1) Develop corrective action objectives; (2) Identify corrective action alternative screening criteria; (3) Develop corrective action alternatives; (4) Perform detailed and comparative evaluations of the corrective action alternatives in relation to the corrective action objectives and screening criteria; and (5) Recommend a preferred corrective action alternative for the subsurface at CNTA. A Corrective Action Investigation (CAI) was performed in several stages from 1999 to 2003, as set forth in the ''Corrective Action Investigation Plan for the Central Nevada Test Area Subsurface Sites (Corrective Action Unit No. 443)'' (DOE/NV, 1999). Groundwater modeling was the primary activity of the CAI. Three phases of modeling were conducted for the Faultless underground nuclear test. The first involved the gathering and interpretation of geologic and hydrogeologic data into a three-dimensional numerical model of groundwater flow, and use of the output of the flow model for a transport model of radionuclide release

  17. Corrective Action Decision Document for Corrective Action Unit 5: Landfills, Nevada Test Site, Nevada: Revision No. 0 (with Record of Technical Change No. 1)

    SciTech Connect

    U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office

    2003-10-24

    This Corrective Action Decision Document identifies and rationalizes the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office's selection of a recommended corrective action alternative (CAA) appropriate to facilitate the closure of Corrective Action (CAU) 5: Landfills, Nevada Test Site (NTS), Nevada, under the Federal Facility Agreement and Consent Order. Located in Areas 5, 6, 12, 20, and 23 of the NTS, CAU 5 is comprised of eight corrective action sites (CASs). The corrective action investigation (CAI) of CAU 5 was conducted from October 7, 2002 through January 30, 2003, with geophysical surveys completed from March 6 through May 8, 2002, and topographic surveys conducted from March 11 through April 29, 2003. Contaminants of concern (COCs) were identified only at CAS 12-15-01. Those COCs included total petroleum hydrocarbons and volatile organic compounds. Based on the evaluation of analytical data from the CAI, review of future and current operations in Areas 5, 6, 12, 20, and 23 of the Nevada Test Site, and the detailed and comparative analysis of the potential CAAs, the following single alternative was developed for consideration. Close in Place with Administrative Controls is the recommended alternative for all of the CASs in CAU 5. This alternative was judged to meet all requirements for the technical components evaluated. Additionally, the alternative meets all applicable state and federal regulations for closure of the sites and will eliminate inadvertent intrusion into landfills at CAU 5.

  18. Corrective Action Investigation Plan for Corrective Action Unit 106: Areas 5, 11 Frenchman Flat Atmospheric Sites, Nevada National Security Site, Nevada

    SciTech Connect

    Patrick Matthews

    2011-07-01

    Corrective Action Unit 106 comprises the four corrective action sites (CASs) listed below: • 05-20-02, Evaporation Pond • 05-23-05, Atmospheric Test Site - Able • 05-45-04, 306 GZ Rad Contaminated Area • 05-45-05, 307 GZ Rad Contaminated Area These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable CAAs that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on January 19, 2010, by representatives of the Nevada Division of Environmental Protection and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 106. The presence and nature of contamination at CAU 106 will be evaluated based on information collected from a field investigation. The CAU includes land areas impacted by the release of radionuclides from groundwater pumping during the Radionuclide Migration study program (CAS 05-20-02), a weapons-related airdrop test (CAS 05-23-05), and unknown support activities at two sites (CAS 05-45-04 and CAS 05-45-05). The presence and nature of contamination from surface-deposited radiological contamination from CAS 05-23-05, Atmospheric Test Site - Able, and other types of releases (such as migration and excavation as well as any potential releases discovered during the investigation) from the remaining three CASs will be evaluated using soil samples collected from the locations

  19. Corrective Action Investigation Plan for Corrective Action Unit 561: Waste Disposal Areas, Nevada Test Site, Nevada with ROTC 1, Revision 0

    SciTech Connect

    Grant Evenson

    2008-07-01

    Corrective Action Unit (CAU) 561 is located in Areas 1, 2, 3, 5, 12, 22, 23, and 25 of the Nevada Test Site, which is approximately 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 561 is comprised of the 10 corrective action sites (CASs) listed below: • 01-19-01, Waste Dump • 02-08-02, Waste Dump and Burn Area • 03-19-02, Debris Pile • 05-62-01, Radioactive Gravel Pile • 12-23-09, Radioactive Waste Dump • 22-19-06, Buried Waste Disposal Site • 23-21-04, Waste Disposal Trenches • 25-08-02, Waste Dump • 25-23-21, Radioactive Waste Dump • 25-25-19, Hydrocarbon Stains and Trench These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation before evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on April 28, 2008, by representatives of the Nevada Division of Environmental Protection; U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office; Stoller-Navarro Joint Venture; and National Security Technologies, LLC. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 561. Appendix A provides a detailed discussion of the DQO methodology and the DQOs specific to each CAS. The scope of the Corrective Action Investigation for CAU 561 includes the following activities: • Move surface debris and/or materials, as needed, to facilitate sampling. • Conduct radiological surveys

  20. Action preparation modulates sensory perception in unseen personal space: An electrophysiological investigation.

    PubMed

    Job, Xavier E; de Fockert, Jan W; van Velzen, José

    2016-08-01

    Behavioural and electrophysiological evidence has demonstrated that preparation of goal-directed actions modulates sensory perception at the goal location before the action is executed. However, previous studies have focused on sensory perception in areas of peripersonal space. The present study investigated visual and tactile sensory processing at the goal location of upcoming movements towards the body, much of which is not visible, as well as visible peripersonal space. A motor task cued participants to prepare a reaching movement towards goals either in peripersonal space in front of them or personal space on the upper chest. In order to assess modulations of sensory perception during movement preparation, event-related potentials (ERPs) were recorded in response to task-irrelevant visual and tactile probe stimuli delivered randomly at one of the goal locations of the movements. In line with previous neurophysiological findings, movement preparation modulated visual processing at the goal of a movement in peripersonal space. Movement preparation also modulated somatosensory processing at the movement goal in personal space. The findings demonstrate that tactile perception in personal space is subject to similar top-down sensory modulation by motor preparation as observed for visual stimuli presented in peripersonal space. These findings show for the first time that the principles and mechanisms underlying adaptive modulation of sensory processing in the context of action extend to tactile perception in unseen personal space.

  1. WSSRAP chemical plant geotechnical investigations for the Weldon Spring Site Remedial Action Project, Weldon Spring, Missouri

    SciTech Connect

    Not Available

    1990-12-01

    This document has been prepared for the United states Department of Energy (DOE) Weldon Spring Site Remedial Action Project (WSSRAP) by the Project Management Contractor (PMC), which consists of MK-Ferguson Company (MKF) and Morrison Knudsen Corporation Environmental Services Group (MKES) with Jacobs Engineering Group (JEG) as MKF's predesignated subcontractor. This report presents the results of site geotechnical investigations conducted by the PMC in the vicinity of the Weldon Spring chemical plant and raffinate pits (WSCP/RP) and in potential on-site and off-site clayey material borrow sources. The WSCP/RP is the proposed disposal cell (DC) site. 39 refs., 24 figs., 12 tabs.

  2. Comparative investigations of manual action representations: evidence that chimpanzees represent the costs of potential future actions involving tools

    PubMed Central

    Frey, Scott H.; Povinelli, Daniel J.

    2012-01-01

    The ability to adjust one's ongoing actions in the anticipation of forthcoming task demands is considered as strong evidence for the existence of internal action representations. Studies of action selection in tool use reveal that the behaviours that we choose in the present moment differ depending on what we intend to do next. Further, they point to a specialized role for mechanisms within the human cerebellum and dominant left cerebral hemisphere in representing the likely sensory costs of intended future actions. Recently, the question of whether similar mechanisms exist in other primates has received growing, but still limited, attention. Here, we present data that bear on this issue from a species that is a natural user of tools, our nearest living relative, the chimpanzee. In experiment 1, a subset of chimpanzees showed a non-significant tendency for their grip preferences to be affected by anticipation of the demands associated with bringing a tool's baited end to their mouths. In experiment 2, chimpanzees' initial grip preferences were consistently affected by anticipation of the forthcoming movements in a task that involves using a tool to extract a food reward. The partial discrepancy between the results of these two studies is attributed to the ability to accurately represent differences between the motor costs associated with executing the two response alternatives available within each task. These findings suggest that chimpanzees are capable of accurately representing the costs of intended future actions, and using those predictions to select movements in the present even in the context of externally directed tool use. PMID:22106426

  3. Corrective Action Investigation Plan for Corrective Action Unit No. 423: Building 03-60 Underground Discharge Point, Tonopah Test Range, Nevada

    SciTech Connect

    DOE /NV

    1997-10-01

    This Corrective Action Investigation Plan (CAIP) has been developed in accordance with the Federal Facility Agreement and Consent Order (FFACO) that was agreed to by the US Department of Energy, Nevada Operations Office (DOE/NV), the State of Nevada Division of Environmental Protection (NDEP), and the US Department of Defense. The CAIP is a document that provides or references all of the specific information for investigation activities associated with Corrective Action Units (CAUS) or Corrective Action Sites (CASs) (FFACO, 1996). As per the FFACO (1996), CASs are sites potentially requiring corrective action(s) and may include solid waste management units or individual disposal or release sites. Corrective Action Units consist of one or more CASs grouped together based on geography, technical similarity, or agency responsibility for the purpose of determining corrective actions. This CAIP contains the environmental sample collection objectives and the criteria for conducting site investigation activities at CAU No. 423, the Building 03-60 Underground Discharge Point (UDP), which is located in Area 3 at the Tonopah Test Range (TTR). The TTR, part of the Nellis Air Force Range, is approximately 225 kilometers (km) (140 miles [mi]) northwest of Las Vegas, Nevada (Figures 1-1 and 1-2). Corrective Action Unit No. 423 is comprised of only one CAS (No. 03-02-002-0308), which includes the Building 03-60 UDP and an associated discharge line extending from Building 03-60 to a point approximately 73 meters (m) (240 feet [ft]) northwest as shown on Figure 1-3.

  4. Formation of refractory metal nuggets and their link to the history of CAIs

    NASA Astrophysics Data System (ADS)

    Schwander, D.; Kööp, L.; Berg, T.; Schönhense, G.; Heck, P. R.; Davis, A. M.; Ott, U.

    2015-11-01

    Ca, Al-rich inclusions (CAIs) often contain numerous refractory metal nuggets (RMNs), consisting of elements like Os, Ir, Mo, Pt and Ru. The nuggets are usually thought to have formed by equilibrium condensation from a gas of solar composition, simultaneously with or prior to oxide and silicate minerals. However, the exact mechanisms responsible for their extremely variable compositions, small sizes and associations with CAI minerals remain puzzling. Expanding on previous work on chemically separated RMNs, we have studied a large number of RMNs within their host CAIs from three different meteorite types, i.e., the highly primitive chondrite Acfer 094 (C2-ungrouped), Allende (CV3ox) and Murchison (CM2). Our results show several inconsistencies between the observed features and a direct condensation origin, including a lack of correlated abundance variations in the refractory metals that are expected from variations in condensation temperature. Instead, we show that most RMN features are consistent with RMN formation by precipitation from a CAI liquid enriched in refractory metals. This scenario is additionally supported by the common occurrence of RMNs in CAIs with clear melt crystallization textures as well as the occurrence of synthetic RMNs with highly variable compositions in run products from Schwander et al. (2015). In some cases, the sizes of meteoritic RMNs correlate with the sizes of their host minerals in CAIs, which indicates common cooling rates.

  5. Scientific rigour and innovations in participatory action research investigating workplace learning in continuing interprofessional education.

    PubMed

    Langlois, Sophie; Goudreau, Johanne; Lalonde, Lyne

    2014-05-01

    The persistent theory-practice gap shows how challenging it can be for healthcare professionals to keep updating their practices. The continuing education challenges are partly explained by the tremendous stream of new discoveries in health and the epidemic of multi-morbid conditions. Participatory action research (PAR) is used in healthcare as a research approach that capitalizes on people's resources to better understand and enhance their professional practices. PAR thus can consolidate our knowledge on workplace learning in continuing interprofessional education while directly improving quality of care. However, PAR lacks clear scientific criteria to ensure the consistency between the investigators' methodology and philosophy, which jeopardize its credibility. This paper outlines the principles of rigour in PAR and describes the additions of a preliminary planning phase to Kemmis and McTaggart's PAR description as well as the use of the professional co-development group, an action-oriented data collection method. We believe that this will help PAR co-participants achieve improved scientific rigour and encourage more investigators to collaborate through this research approach contributing to the advancement of knowledge on workplace learning in continuing interprofessional education. PMID:24559150

  6. Action of palmatine on Tetrahymena thermophila BF5 growth investigated by microcalorimetry.

    PubMed

    Kong, Wei-Jun; Zhao, Yan-Ling; Xiao, Xiao-He; Li, Zu-Lun; Ren, Yong-Shen

    2009-09-15

    Using a thermal activity monitor (TAM) air isothermal microcalorimeter with ampoule mode, the thermo-genic curves of the metabolism of Tetrahymena thermophila BF(5) growth at 28 degrees C were obtained and the action of palmatine on it was investigated. Meanwhile, the biomass change during the process of T. thermophila BF(5) growth coexisted with palmatine was studied by a haemacytometer. The results showed that a low concentration (50 microg/mL) of palmatine began to inhibit the growth of T. thermophila BF(5), and when the concentration of palmatine reached 600 microg/mL, T. thermophila BF(5) could not grow at all. The relationship between the growth rate constant (k) and the concentration c was almost linear with the correlation coefficient of 0.9957, showing the strong toxic action of palmatine on T. thermophila BF(5) growth. The biomass during T. thermophila BF(5) growth decreased obviously by the addition of palmatine at different concentrations. The investigation of biomass agreed well with the results obtained by means of microcalorimetry.

  7. Corrective Action Investigation Plan for Corrective Action Unit 511: Waste Dumps (Piles & Debris), Nevada Test Site, Nevada, Rev. No.: 0 with ROTC 1

    SciTech Connect

    David A. Strand

    2004-08-01

    This Corrective Action Investigation Plan for Corrective Action Unit 511: Waste Dumps (Piles & Debris), Nevada Test Site, Nevada, has been developed in accordance with the Federal Facility Agreement and Consent Order that was agreed to by the State of Nevada, U.S. Department of Energy, and the U.S. Department of Defense. The general purpose of the investigation is to ensure adequate data are collected to provide sufficient and reliable information to identify, evaluate, and select viable corrective actions. This Corrective Action Investigation Plan provides investigative details for CAU 511, whereas programmatic aspects of this project are discussed in the ''Project Management Plan'' (DOE/NV, 1994). General field and laboratory quality assurance and quality control issues are presented in the ''Industrial Sites Quality Assurance Project Plan'' (NNSA/NV, 2002). Health and safety aspects of the project are documented in the current version of the Environmental Engineering Services Contractor's Health and Safety Plan and will be supplemented with a site-specific safety basis document. Corrective Action Unit 511 is comprised of the following nine corrective action sites in Nevada Test Site Areas 3, 4, 6, 7, 18, and 19: (1) 03-08-02, Waste Dump (Piles & Debris); (2) 03-99-11, Waste Dump (Piles); (3) 03-99-12, Waste Dump (Piles & Debris); (4) 04-99-04, Contaminated Trench/Berm; (5) 06-16-01, Waste Dump (Piles & Debris); (6) 06-17-02, Scattered Ordnance/Automatic Weapons Range; (7) 07-08-01, Contaminated Mound; (8) 18-99-10, Ammunition Dump; and (9) 19-19-03, Waste Dump (Piles & Debris). Corrective Action Sites 18-99-10 and 19-19-03 were identified after a review of the ''1992 RCRA Part B Permit Application for Waste Management Activities at the Nevada Test Site, Volume IV, Section L Potential Solid Waste Management Unit'' (DOE/NV, 1992). The remaining seven sites were first identified in the 1991 Reynolds Electrical & Engineering Co., Inc. document entitled, ''Nevada

  8. Corrective action investigation plan for Central Nevada Test Area CAU No. 417

    SciTech Connect

    1997-01-01

    This Corrective Action Investigation Plan (CAIP) is part of a US Department of Energy (DOE)-funded environmental investigation of the Central Nevada Test Area (CNTA). The CNTA is located in Hot Creek Valley in Nye County, Nevada, adjacent to US Highway 6, about 15 kilometers (10 miles) northeast of Warm Springs. The CNTA was the site of Project Faultless, a nuclear device detonated in the subsurface by the US Atomic Energy Commission (AEC) in January 1968. The purpose of this test was to gauge the seismic effects of relatively large, high-yield detonations completed outside of the Nevada Test Site (NTS). The test was also used to determine the suitability of the site for future large detonations. The yield of the Faultless test was between 200 kilotons and 1 megaton (DOE, 1994c).

  9. American Thyroid Association Guide to Investigating Thyroid Hormone Economy and Action in Rodent and Cell Models

    PubMed Central

    Anderson, Grant; Forrest, Douglas; Galton, Valerie Anne; Gereben, Balázs; Kim, Brian W.; Kopp, Peter A.; Liao, Xiao Hui; Obregon, Maria Jesus; Peeters, Robin P.; Refetoff, Samuel; Sharlin, David S.; Simonides, Warner S.; Weiss, Roy E.; Williams, Graham R.

    2014-01-01

    Background: An in-depth understanding of the fundamental principles that regulate thyroid hormone homeostasis is critical for the development of new diagnostic and treatment approaches for patients with thyroid disease. Summary: Important clinical practices in use today for the treatment of patients with hypothyroidism, hyperthyroidism, or thyroid cancer are the result of laboratory discoveries made by scientists investigating the most basic aspects of thyroid structure and molecular biology. In this document, a panel of experts commissioned by the American Thyroid Association makes a series of recommendations related to the study of thyroid hormone economy and action. These recommendations are intended to promote standardization of study design, which should in turn increase the comparability and reproducibility of experimental findings. Conclusions: It is expected that adherence to these recommendations by investigators in the field will facilitate progress towards a better understanding of the thyroid gland and thyroid hormone dependent processes. PMID:24001133

  10. Corrective Action Investigation Plan for Corrective Action Unit 252: Area 25 Engine Test Stand 1 Decontamination Pad, Nevada Test Site, Nevada

    SciTech Connect

    U.S. Department of Energy, Nevada Operations Office

    1999-08-20

    This Corrective Action Investigation Plan contains the U.S. Department of Energy, Nevada Operations Office's approach to collect the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit 252 under the Federal Facility Agreement and Consent Order. Corrective Action Unit 252 consists of Corrective Action Site (CAS) 25-07-02, Engine Test Stand-1 (ETS-1) Decontamination Pad. Located in Area 25 at the intersection of Road H and Road K at the Nevada Test Site, ETS-1 was designed for use as a mobile radiation checkpoint and for vehicle decontamination. The CAS consists of a concrete decontamination pad with a drain, a gravel-filled sump, two concrete trailer pads, and utility boxes. Constructed in 1966, the ETS-1 facility was part of the Nuclear Rocket Development Station (NRDS) complex and used to test nuclear rockets. The ETS-1 Decontamination Pad and mobile radiation check point was built in 1968. The NRDS complex ceased primary operations in 1973. Based on site history, the focus of the field investigation activities will be to determine if any primary contaminants of potential concern (COPCs) (including radionuclides, total volatile organic compounds, total semivolatile organic compounds, total petroleum hydrocarbons as diesel-range organics, Resource Conservation and Recovery Act metals, total pesticides, and polychlorinated biphenyls) are present at this site. Vertical extent of migration of suspected vehicle decontamination effluent COPCs is expected to be less than 12 feet below ground surface. Lateral extent of migration of COPCs is expected to be limited to the sump area or near the northeast corner of the decontamination pad. Using a biased sampling approach, near-surface and subsurface sampling will be conducted at the suspected worst-case areas including the sump and soil near the northeast corner of the decontamination pad. The results of this field investigation will support a defensible e valuation

  11. Corrective Action Investigation Plan for Corrective Action Unit 106: Areas 5, 11 Frenchman Flat Atmospheric Sites, Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews

    2010-04-01

    Corrective Action Unit (CAU) 106 is located in Area 5 of the Nevada Test Site, which is approximately 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 106 comprises the five corrective action sites (CASs) listed below: •05-23-02, GMX Alpha Contaminated Area •05-23-05, Atmospheric Test Site - Able •05-45-01, Atmospheric Test Site - Hamilton •05-45-04, 306 GZ Rad Contaminated Area •05-45-05, 307 GZ Rad Contaminated Area These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable CAAs that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on January 19, 2010, by representatives of the Nevada Division of Environmental Protection and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 106. The presence and nature of contamination at CAU 106 will be evaluated based on information collected from a field investigation. The CAU includes land areas impacted by the release of radionuclides from a weapons-effect tower test (CAS 05-45-01), a weapons-related airdrop test (CAS 05-23-05), “equation of state” experiments (CAS 05-23-02), and unknown support activities at two sites (CAS 05-45-04 and CAS 05-45-05). Surface-deposited radiological contamination will be evaluated based on a comparison of the total effective dose (TED) at sample plot locations to the dose

  12. Corrective action investigation plan for Corrective Action Unit Number 423: Building 03-60 Underground Discharge Point, Tonopah Test Range, Nevada

    SciTech Connect

    1997-10-27

    This Corrective Action Investigation Plan (CAIP) contains the environmental sample collection objectives and the criteria for conducting site investigation activities at Corrective Action Unit (CAU) Number 423, the Building 03-60 Underground Discharge Point (UDP), which is located in Area 3 at the Tonopah Test Range (TTR). The TTR, part of the Nellis Air Force Range, is approximately 225 kilometers (140 miles) northwest of Las Vegas, Nevada. CAU Number 423 is comprised of only one Corrective Action Site (CAS) which includes the Building 03-60 UDP and an associated discharge line extending from Building 03-60 to a point approximately 73 meters (240 feet) northwest. The UDP was used between approximately 1965 and 1990 to dispose of waste fluids from the Building 03-60 automotive maintenance shop. It is likely that soils surrounding the UDP have been impacted by oil, grease, cleaning supplies and solvents as well as waste motor oil and other automotive fluids released from the UDP.

  13. Taking Action: A Cross-Modal Investigation of Discourse-Level Representations

    PubMed Central

    Kaiser, Elsi

    2012-01-01

    Segmenting stimuli into events and understanding the relations between those events is crucial for understanding the world. For example, on the linguistic level, successful language use requires the ability to recognize semantic coherence relations between events (e.g., causality, similarity). However, relatively little is known about the mental representation of discourse structure. We report two experiments that used a cross-modal priming paradigm to investigate how humans represent the relations between events. Participants repeated a motor action modeled by the experimenter (e.g., rolled a ball toward mini bowling pins to knock them over), and then completed an unrelated sentence-continuation task (e.g., provided a continuation for “Peter scratched John.…”). In two experiments, we tested whether and how the coherence relations represented by the motor actions (e.g., causal events vs. non-causal events) influence participants’ performance in the linguistic task. (A production study was also conducted to explore potential syntactic priming effects.) Our analyses focused on the coherence relations between the prompt sentences and participants’ continuations, as well as the referential shifts in the continuations. As a whole, the results suggest that the mental representations activated by motor actions overlap with the mental representations used during linguistic discourse-level processing, but nevertheless contain fine-grained information about sub-types of causality (reaction vs. consequence). In addition, the findings point to parallels between shifting one’s attention from one-event to another and shifting one’s attention from one referent to another, and indicate that the event structure of causal sequences is conceptualized more like single events than like two distinct events. As a whole, the results point toward common representations activated by motor sequences and discourse-semantic relations, and further our understanding of the mental

  14. Corrective Action Decision Document/Closure Report for Corrective Action Unit 374: Area 20 Schooner Unit Crater, Nevada National Security Site, Nevada with ROTC 1, Revision 0

    SciTech Connect

    Patrick Matthews

    2011-07-01

    Corrective Action Unit 374 comprises five corrective action sites (CASs): • 18-22-05, Drum • 18-22-06, Drums (20) • 18-22-08, Drum • 18-23-01, Danny Boy Contamination Area • 20-45-03, U-20u Crater (Schooner) The purpose of this Corrective Action Decision Document/Closure Report is to provide justification and documentation supporting the recommendation that no further corrective action is needed for CAU 374 based on the implementation of corrective actions. The corrective action of closure in place with administrative controls was implemented at CASs 18-23-01 and 20-45-03, and a corrective action of removing potential source material (PSM) was conducted at CAS 20-45-03. The other CASs require no further action; however, best management practices of removing PSM and drums at CAS 18-22-06, and removing drums at CAS 18-22-08 were performed. Corrective action investigation (CAI) activities were performed from May 4 through October 6, 2010, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 374: Area 20 Schooner Unit Crater, Nevada Test Site, Nevada. The approach for the CAI was divided into two facets: investigating the primary release of radionuclides and investigating other releases (migration in washes and chemical releases). The purpose of the CAI was to fulfill data needs as defined during the data quality objective (DQO) process. The CAU 374 dataset of investigation results was evaluated based on the data quality indicator parameters. This evaluation demonstrated the dataset is acceptable for use in fulfilling the DQO data needs. Analytes detected during the CAI were evaluated against final action levels (FALs) established in this document. Radiological doses exceeding the FAL of 25 millirem per year were found to be present in the surface soil that was sampled. It is assumed that radionuclide levels present in subsurface media within the craters and ejecta fields (default contamination boundaries) at the Danny Boy and

  15. Corrective Action Investigation Plan for Corrective Action Unit 571: Area 9 Yucca Flat Plutonium Dispersion Sites, Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Bailey, Bernadine; Matthews, Patrick

    2013-07-01

    CAU 571 is a grouping of sites where there has been a suspected release of contamination associated with nuclear testing. This document describes the planned investigation of CAU 571, which comprises the following corrective action sites (CASs): • 09-23-03, Atmospheric Test Site S-9F • 09-23-04, Atmospheric Test Site T9-C • 09-23-12, Atmospheric Test Site S-9E • 09-23-13, Atmospheric Test Site T-9D • 09-45-01, Windrows Crater These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable CAAs that will be presented in the investigation report. The sites will be investigated based on the data quality objectives (DQOs) developed on March 6, 2013, by representatives of the Nevada Division of Environmental Protection and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (now the Nevada Field Office). The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 571. The site investigation process will also be conducted in accordance with the Soils Activity Quality Assurance Plan, which establishes requirements, technical planning, and general quality practices to be applied to this activity. The potential contamination sources associated with CAU 571 CASs are from nuclear testing activities. The DQO process resulted in an assumption that total effective dose (TED) within a default contamination boundary exceeds the final action level (FAL) and requires corrective action. The presence and nature of contamination outside the default

  16. Corrective Action Investigation Plan for Corrective Action Unit 541: Small Boy Nevada National Security Site and Nevada Test and Training Range, Nevada with ROTC 1

    SciTech Connect

    Matthews, Patrick

    2014-09-01

    Corrective Action Unit (CAU) 541 is co-located on the boundary of Area 5 of the Nevada National Security Site and Range 65C of the Nevada Test and Training Range, approximately 65 miles northwest of Las Vegas, Nevada. CAU 541 is a grouping of sites where there has been a suspected release of contamination associated with nuclear testing. This document describes the planned investigation of CAU 541, which comprises the following corrective action sites (CASs): 05-23-04, Atmospheric Tests (6) - BFa Site; 05-45-03, Atmospheric Test Site - Small Boy. These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable CAAs that will be presented in the investigation report. The sites will be investigated based on the data quality objectives (DQOs) developed on April 1, 2014, by representatives of the Nevada Division of Environmental Protection; U.S. Air Force; and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Field Office. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 541. The site investigation process also will be conducted in accordance with the Soils Activity Quality Assurance Plan, which establishes requirements, technical planning, and general quality practices to be applied to this activity. The potential contamination sources associated with CASs 05-23-04 and 05-45-03 are from nuclear testing activities conducted at the Atmospheric Tests (6) - BFa Site and Atmospheric Test Site - Small Boy sites. The presence and nature of

  17. Search for extinct 36Cl: Vigarano CAIs, the Pink Angel from Allende, and a Ningqiang chondrule

    NASA Astrophysics Data System (ADS)

    Nakashima, Daisuke; Ott, Ulrich; Hoppe, Peter; El Goresy, Ahmed

    2008-12-01

    We have searched for excesses of 36S derived from the decay of extinct 36Cl in sodalite, a secondary Cl-rich mineral, in Ca-Al-rich inclusions (CAIs) from the Vigarano and Allende CV3 chondrites and in a chondrule from the Ningqiang carbonaceous chondrite. The presence of sodalite in two CAIs from Vigarano and its absence from surrounding CAI fragments suggests sodalite formation after CAI fragmentation. As for sodalite in the Allende Pink Angel CAI, oxygen isotopic compositions have been interpreted as indicative of high temperature interactions, thus suggesting formation prior to accretion to the parent body, probably in a nebular setting. Sodalite in the Ningqiang chondrule is considered to have formed via alkali-Ca exchange, which is believed to have occurred before accretion to the parent body. Sodalites in the Vigarano CAIs and in the Ningqiang chondrule show no clear evidence for the presence of radiogenic 36S. The inferred 2 σ upper limits for 36Cl/ 35Cl at the time of sodalite formation are 1.6 × 10 -6 (Vigarano CAIs) and 3.3 × 10 -6 (Ningqiang chondrule), respectively. In the Pink Angel CAI sodalite exhibits small 36S excesses which weakly correlate with 35Cl/ 34S ratios. The inferred 36Cl/ 35Cl ratio of (1.8 ± 2.2) × 10 -6 (2 σ error) is lower than that found by Hsu et al. [Hsu, W., Guan, Y., Leshin, L. A., Ushikubo, T. and Wasserburg, G. J. (2006) A late episode of irradiation in the early solar system: Evidence from extinct 36Cl and 26Al in meteorites. Astrophys. J. 640, 525-529], thus indicative of heterogeneous distribution of 36Cl in this CAI. Spallation reactions induced by energetic particles from the young Sun are suggested for the origin of 36Cl, similar to the case of 10Be. While 10Be appears to be present in roughly equal abundance in all studied CAIs, our study indicates the level of 36Cl abundances to be variable so that there seems to be no simple relationship between 10Be and 36Cl. This would be expected if trapped cosmic rays rather

  18. Investigation of the mechanisms of action behind Electromotive Drug Administration (EMDA)

    PubMed Central

    Vásquez, Juan Luis; Miklavčič, Damijan; Hermann, Gregers G.G.; Gehl, Julie

    2016-01-01

    Objective Bladder cancer is a cause of considerable morbidity worldwide. Electromotive Drug Administration is a method that combines intravesical chemotherapy with local electric field application. Electroporation has been suggested among other mechanisms as having a possible role in the therapy, so the goal of the present study was to investigate the electric fields present in the bladder wall during the treatment to determine which mechanisms might be involved. Material and Methods Electromotive Drug Administration involves applying intravesical mitomycin C with direct current of 20 mA delivered through a catheter electrode for 30 min. For numerical electric field computation we built a 3-D nonhomogeneous patient specific model based on CT images and used finite element method simulations to determine the electric fields in the whole body. Results Results indicate that highest electric field in the bladder wall was 37.7 V/m. The mean electric field magnitude in the bladder wall was 3.03 V/m. The mean magnitude of the current density in the bladder wall was 0.61 A/m2. Conclusions The present study shows that electroporation is not the mechanism of action in EMDA. A more likely explanation of the mechanism of action is iontophoretic forces increasing the mitomycin C concentration in the bladder wall. PMID:27635313

  19. Investigation of the mechanisms of action behind Electromotive Drug Administration (EMDA)

    PubMed Central

    Vásquez, Juan Luis; Miklavčič, Damijan; Hermann, Gregers G.G.; Gehl, Julie

    2016-01-01

    Objective Bladder cancer is a cause of considerable morbidity worldwide. Electromotive Drug Administration is a method that combines intravesical chemotherapy with local electric field application. Electroporation has been suggested among other mechanisms as having a possible role in the therapy, so the goal of the present study was to investigate the electric fields present in the bladder wall during the treatment to determine which mechanisms might be involved. Material and Methods Electromotive Drug Administration involves applying intravesical mitomycin C with direct current of 20 mA delivered through a catheter electrode for 30 min. For numerical electric field computation we built a 3-D nonhomogeneous patient specific model based on CT images and used finite element method simulations to determine the electric fields in the whole body. Results Results indicate that highest electric field in the bladder wall was 37.7 V/m. The mean electric field magnitude in the bladder wall was 3.03 V/m. The mean magnitude of the current density in the bladder wall was 0.61 A/m2. Conclusions The present study shows that electroporation is not the mechanism of action in EMDA. A more likely explanation of the mechanism of action is iontophoretic forces increasing the mitomycin C concentration in the bladder wall.

  20. Phase II Corrective Action Investigation Plan for Corrective Action Units 101 and 102: Central and Western Pahute Mesa, Nevada Test Site, Nye County, Nevada, Revision 2

    SciTech Connect

    Jeff Wurtz

    2009-07-01

    This Phase II CAIP describes new work needed to potentially reduce uncertainty and achieve increased confidence in modeling results. This work includes data collection and data analysis to refine model assumptions, improve conceptual models of flow and transport in a complex hydrogeologic setting, and reduce parametric and structural uncertainty. The work was prioritized based on the potential to reduce model uncertainty and achieve an acceptable level of confidence in the model predictions for flow and transport, leading to model acceptance by NDEP and completion of the Phase II CAI stage of the UGTA strategy.

  1. Corrective Action Investigation Plan for Corrective Action Unit 428: Area 3 Septic Waste Systems 1 and 5, Tonopah Test Range, Nevada, REVISION 0, march 1999

    SciTech Connect

    DOE /NV

    1999-03-26

    The Corrective Action Investigation Plan for Corrective Action Unit 428, Area 3 Septic Waste Systems 1 and 5, has been developed in accordance with the Federal Facility Agreement and Consent Order that was agreed to by the U. S. Department of Energy, Nevada Operations Office; the State of Nevada Division of Environmental Protection; and the U. S. Department of Defense. Corrective Action Unit 428 consists of Corrective Action Sites 03- 05- 002- SW01 and 03- 05- 002- SW05, respectively known as Area 3 Septic Waste System 1 and Septic Waste System 5. This Corrective Action Investigation Plan is used in combination with the Work Plan for Leachfield Corrective Action Units: Nevada Test Site and Tonopah Test Range, Nevada , Rev. 1 (DOE/ NV, 1998c). The Leachfield Work Plan was developed to streamline investigations at leachfield Corrective Action Units by incorporating management, technical, quality assurance, health and safety, public involvement, field sampling, and waste management information common to a set of Corrective Action Units with similar site histories and characteristics into a single document that can be referenced. This Corrective Action Investigation Plan provides investigative details specific to Corrective Action Unit 428. A system of leachfields and associated collection systems was used for wastewater disposal at Area 3 of the Tonopah Test Range until a consolidated sewer system was installed in 1990 to replace the discrete septic waste systems. Operations within various buildings at Area 3 generated sanitary and industrial wastewaters potentially contaminated with contaminants of potential concern and disposed of in septic tanks and leachfields. Corrective Action Unit 428 is composed of two leachfield systems in the northern portion of Area 3. Based on site history collected to support the Data Quality Objectives process, contaminants of potential concern for the site include oil/ diesel range total petroleum hydrocarbons, and Resource Conservation

  2. Corrective Action Investigation Plan for Corrective Action Unit 151: Septic Systems and Discharge Area, Nevada Test Site, Nevada, Rev. No.: 0

    SciTech Connect

    David A. Strand

    2004-06-01

    This Corrective Action Investigation Plan (CAIP) contains project-specific information for conducting site investigation activities at Corrective Action Unit (CAU) 151: Septic Systems and Discharge Area, Nevada Test Site, Nevada. Information presented in this CAIP includes facility descriptions, environmental sample collection objectives, and criteria for the selection and evaluation of environmental corrective action alternatives. Corrective Action Unit 151 is located in Areas 2, 12, 18, and 20 of the Nevada Test Site, which is 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 151 is comprised of the nine Corrective Action Sites (CAS) listed below: (1) 02-05-01, UE-2ce Pond; (2) 12-03-01, Sewage Lagoons (6); (3) 12-04-01, Septic Tanks; (4) 12-04-02, Septic Tanks; (5) 12-04-03, Septic Tank; (6) 12-47-01, Wastewater Pond; (7) 18-03-01, Sewage Lagoon; (8) 18-99-09, Sewer Line (Exposed); and (9) 20-19-02, Photochemical Drain. The CASs within CAU 151 are discharge and collection systems. Corrective Action Site 02-05-01 is located in Area 2 and is a well-water collection pond used as a part of the Nash test. Corrective Action Sites 12-03-01, 12-04-01, 12-04-02, 12-04-03, and 12-47-01 are located in Area 12 and are comprised of sewage lagoons, septic tanks, associated piping, and two sumps. The features are a part of the Area 12 Camp housing and administrative septic systems. Corrective Action Sites 18-03-01 and 18-99-09 are located in the Area 17 Camp in Area 18. These sites are sewage lagoons and associated piping. The origin and terminus of CAS 18-99-09 are unknown; however, the type and configuration of the pipe indicates that it may be a part of the septic systems in Area 18. Corrective Action Site 20-19-02 is located in the Area 20 Camp. This site is comprised of a surface discharge of photoprocessing chemicals.

  3. Functionally Optimized Neuritogenic Farinosone C Analogs: SAR-Study and Investigations on Their Mode of Action

    PubMed Central

    2013-01-01

    Several natural products derived from entomopathogenic fungi have been shown to initiate neuronal differentiation in the rat pheochromocytoma PC12 cell line. After the successful completion of the total synthesis program, the reduction of structural complexity while retaining biological activity was targeted. In this study, farinosone C served as a lead structure and inspired the preparation of small molecules with reduced complexity, of which several were able to induce neurite outgrowth. This allowed for the elaboration of a detailed structure–activity relationship. Investigations on the mode of action utilizing a computational similarity ensemble approach suggested the involvement of the endocannabinoid system as potential target for our analogs and also led to the discovery of four potent new endocannabinoid transport inhibitors. PMID:24900793

  4. Corrective Action Investigation Plan for Corrective Action Unit 105: Area 2 Yucca Flat Atmospheric Test Sites Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews

    2012-09-01

    Corrective Action Unit (CAU) 105 is located in Area 2 of the Nevada National Security Site, which is approximately 65 miles northwest of Las Vegas, Nevada. CAU 105 is a geographical grouping of sites where there has been a suspected release of contamination associated with atmospheric nuclear testing. This document describes the planned investigation of CAU 105, which comprises the following corrective action sites (CASs): • 02-23-04, Atmospheric Test Site - Whitney • 02-23-05, Atmospheric Test Site T-2A • 02-23-06, Atmospheric Test Site T-2B • 02-23-08, Atmospheric Test Site T-2 • 02-23-09, Atmospheric Test Site - Turk These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable CAAs that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on April 30, 2012, by representatives of the Nevada Division of Environmental Protection and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 105. The site investigation process will also be conducted in accordance with the Soils Activity Quality Assurance Plan, which establishes requirements, technical planning, and general quality practices to be applied to this activity. The potential contamination sources associated with all CAU 105 CASs are from atmospheric nuclear testing activities. The presence and nature of contamination at CAU

  5. Corrective Action Investigation Plan for Corrective Action Unit 570: Area 9 Yucca Flat Atmospheric Test Sites Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews

    2012-08-01

    CAU 570 comprises the following six corrective action sites (CASs): • 02-23-07, Atmospheric Test Site - Tesla • 09-23-10, Atmospheric Test Site T-9 • 09-23-11, Atmospheric Test Site S-9G • 09-23-14, Atmospheric Test Site - Rushmore • 09-23-15, Eagle Contamination Area • 09-99-01, Atmospheric Test Site B-9A These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable CAAs that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on April 30, 2012, by representatives of the Nevada Division of Environmental Protection and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 570. The site investigation process will also be conducted in accordance with the Soils Activity Quality Assurance Plan, which establishes requirements, technical planning, and general quality practices to be applied to this activity. The presence and nature of contamination at CAU 570 will be evaluated based on information collected from a field investigation. Radiological contamination will be evaluated based on a comparison of the total effective dose at sample locations to the dose-based final action level. The total effective dose will be calculated as the total of separate estimates of internal and external dose. Results from the analysis of soil samples will be used to calculate internal radiological

  6. Corrective Action Investigation Plan for Corrective Action Unit 366: Area 11 Plutonium Valley Dispersion Sites, Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews

    2011-09-01

    Corrective Action Unit 366 comprises the six corrective action sites (CASs) listed below: (1) 11-08-01, Contaminated Waste Dump No.1; (2) 11-08-02, Contaminated Waste Dump No.2; (3) 11-23-01, Radioactively Contaminated Area A; (4) 11-23-02, Radioactively Contaminated Area B; (5) 11-23-03, Radioactively Contaminated Area C; and (6) 11-23-04, Radioactively Contaminated Area D. These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of CAAs that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed July 6, 2011, by representatives of the Nevada Division of Environmental Protection and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 366. The presence and nature of contamination at CAU 366 will be evaluated based on information collected from a field investigation. Radiological contamination will be evaluated based on a comparison of the total effective dose (TED) at sample locations to the dose-based final action level (FAL). The TED will be calculated by summing the estimates of internal and external dose. Results from the analysis of soil samples collected from sample plots will be used to calculate internal radiological dose. Thermoluminescent dosimeters placed at each sample location will be used to measure external radiological dose. Based on historical documentation of the releases

  7. Evidence for extinct 135Cs from Ba isotopes in Allende CAIs?

    NASA Astrophysics Data System (ADS)

    Bermingham, K. R.; Mezger, K.; Desch, S. J.; Scherer, E. E.; Horstmann, M.

    2014-05-01

    The abundance and distribution of isotopes throughout the Solar System can be used to constrain the number and type of nucleosynthetic events that contributed material to the early nebula. Barium is particularly well suited to quantifying the degree of isotope heterogeneity in the Solar System because it comprises seven stable isotopes that were synthesized by three different nucleosynthetic processes (s-, r-, and p-processes), all of which contributed material to the Solar System. There is also potential contribution to 135Ba from short-lived radioisotope 135Cs, conclusive evidence for which is yet to be reported. Four Allende (CV3) Ca,Al-rich inclusions (CAI 1, CAI 2, CAI 4, CAI 5) and one Allende dark inclusion (DI) were analyzed for Ba isotope variability. Two CAIs (CAI 2 and CAI 5) display 135Ba excesses that are not accompanied by 137Ba anomalies. Calcium-aluminum-rich inclusion 1 displays a 135Ba excess that is possibly coupled with a 137Ba excess, and the remaining refractory inclusions (CAI 2 and DI) have terrestrial Ba isotope compositions. These Ba isotope data are presented in conjunction with published whole rock Ba isotope data from individual Allende CAIs. The enrichment in 135Ba and absence of coupled 137Ba excesses in CAI 2 and CAI 5 is interpreted to indicate that the anomalies are not purely nucleosynthetic in origin but also contain contributions (16-48 ppm) from the decay of short-lived 135Cs. The majority of Allende CAIs studied to date may also have similar contributions from 135Cs on the basis of higher than expected 135Ba excesses if the Ba isotope anomalies were purely nucleosynthetic in origin. The 135Ba anomalies appear not to be coupled with superchondritic Cs/Ba, which may imply that the contribution to 135Ba did not occur via in situ decay of live 135Cs. However, it is feasible that the CAIs had a superchondritic Cs/Ba during decay of 135Cs, but Cs was subsequently removed from the system during aqueous alteration on the parent body

  8. The ethnoecology of Caiçara metapopulations (Atlantic Forest, Brazil): ecological concepts and questions

    PubMed Central

    Begossi, Alpina

    2006-01-01

    The Atlantic Forest is represented on the coast of Brazil by approximately 7,5% of remnants, much of these concentrated on the country's SE coast. Within these southeastern remnants, we still find the coastal Caiçaras who descend from Native Indians and Portuguese Colonizers. The maintenance of such populations, and their existence in spite of the deforestation that occurred on the Atlantic Forest coast, deserves especial attention and analysis. In this study, I address, in particular, the Caiçaras who live on the coast of São Paulo and Rio de Janeiro States, illustrating with examples of coastal inhabitants from other areas, such as Bahia State (NE coast) and of other forested areas (riverine caboclos of the Amazon). The major focus of this study, based on previous research, performed since 1986 in several populations or villages of the Atlantic Forest coast, is to understand the resilience of the Caiçaras, which is analyzed using ecological concepts, such as metapopulation, resilience and adaptive cycles. The Caiçara populations are located on islands (Búzios, Comprida, Grande, Ilhabela, Jaguanum, Gipóia) and on the coast (Bertioga, Puruba, Picinguaba, among others). Information gathered about the Caiçaras regarding the economic cycles of the local regions, along with ecological, historical and economic data available, are used to understand such resilience, and are complemented with comparative examples from the Brazilian Amazon and with variables such as the local restrictions imposed by environmental governmental agencies. PMID:17010204

  9. Mineralogy and Petrology of EK-459-5-1, A Type B1 CAI from Allende

    NASA Technical Reports Server (NTRS)

    Jeffcoat, C. R.; Kerekgyarto, A. G.; Lapen, T. J.; Andreasen, R.; Righter, M.; Ross, D. K.

    2015-01-01

    Calcium-aluminum-rich inclusions (CAIs) are a type of coarse-grained clast composed of Ca-, Al-, and Mg-rich silicates and oxides found in chondrite meteorites. Type B (CAIs) are exclusively found in the CV chondrite meteorites and are the most well studied type of inclusion found in chondritic meteorites. Type B1 CAIs are distinguished by a nearly monomineralic rim of melilite that surrounds an interior predominantly composed of melilite, fassaite (Ti and Al-rich clinopyroxene), anorthite, and spinel with varying amounts of other minor primary and secondary phases. The formation of Type B CAIs has received considerable attention in the course of CAI research and quantitative models, experimental results and observations from Type B inclusions remain largely in disagreement. Recent experimental results and quantitative models have shown that the formation of B1 mantles could have occurred by the evaporative loss of Si and Mg during the crystallization of these objects. However, comparative studies suggest that the lower bulk SiO2 compositions in B1s result in more prior melilite crystallization before the onset of fassaite and anorthite crystallization leading to the formation of thick melilite rich rims in B1 inclusions. Detailed petrographic and cosmochemical studies of these inclusions will further our understanding of these complex objects.

  10. Corrective Action Investigation Plan for Corrective Action Unit 490: Station 44 Burn Area, Tonopah Test Range, Nevada (with Record of Technical Change No.1)

    SciTech Connect

    U.S. Department of Energy, Nevada Operations Office

    2000-06-09

    This Corrective Action Investigation Plan (CAIP) contains the U.S. Department of Energy, Nevada Operations Office's approach to collect the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 490 under the Federal Facility Agreement and Consent Order. Corrective Active Unit 490 consists of four Corrective Action Sites (CASs): 03-56-001-03BA, Fire Training Area (FTA); RG-56-001-RGBA, Station 44 Burn Area; 03-58-001-03FN, Sandia Service Yard; and 09-54-001-09L2, Gun Propellant Burn Area. These CASs are located at the Tonopah Test Range near Areas 3 and 9. Historically, the FTA was used for training exercises where tires and wood were ignited with diesel fuel. Records indicate that water and carbon dioxide were the only extinguishing agents used during these training exercises. The Station 44 Burn Area was used for fire training exercises and consisted of two wooden structures. The two burn areas (ignition of tires, wood, and wooden structures with diesel fuel and water) were limited to the building footprints (10 ft by 10 ft each). The Sandia Service Yard was used for storage (i.e., wood, tires, metal, electronic and office equipment, construction debris, and drums of oil/grease) from approximately 1979 to 1993. The Gun Propellant Burn Area was used from the 1960s to 1980s to burn excess artillery gun propellant, solid-fuel rocket motors, black powder, and deteriorated explosives; additionally, the area was used for the disposal of experimental explosive items. Based on site history, the focus of the field investigation activities will be to: (1) determine the presence of contaminants of potential concern (COPCs) at each CAS, (2) determine if any COPCs exceed field-screening levels and/or preliminary action levels, and (3) determine the nature and extent of contamination with enough certainty to support selection of corrective action alternatives for each CAS. The scope of this CAIP is to resolve the

  11. Corrective Action Investigation Plan for Corrective Action Unit 410: Waste Disposal Trenches, Tonopah Test Range, Nevada, Revision 0 (includes ROTCs 1, 2, and 3)

    SciTech Connect

    NNSA /NV

    2002-07-16

    This Corrective Action Investigation Plan contains the U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office's approach to collect the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 410 under the Federal Facility Agreement and Consent Order. Corrective Action Unit 410 is located on the Tonopah Test Range (TTR), which is included in the Nevada Test and Training Range (formerly the Nellis Air Force Range) approximately 140 miles northwest of Las Vegas, Nevada. This CAU is comprised of five Corrective Action Sites (CASs): TA-19-002-TAB2, Debris Mound; TA-21-003-TANL, Disposal Trench; TA-21-002-TAAL, Disposal Trench; 09-21-001-TA09, Disposal Trenches; 03-19-001, Waste Disposal Site. This CAU is being investigated because contaminants may be present in concentrations that could potentially pose a threat to human health and/or the environment, and waste may have been disposed of with out appropriate controls. Four out of five of these CASs are the result of weapons testing and disposal activities at the TTR, and they are grouped together for site closure based on the similarity of the sites (waste disposal sites and trenches). The fifth CAS, CAS 03-19-001, is a hydrocarbon spill related to activities in the area. This site is grouped with this CAU because of the location (TTR). Based on historical documentation and process know-ledge, vertical and lateral migration routes are possible for all CASs. Migration of contaminants may have occurred through transport by infiltration of precipitation through surface soil which serves as a driving force for downward migration of contaminants. Land-use scenarios limit future use of these CASs to industrial activities. The suspected contaminants of potential concern which have been identified are volatile organic compounds; semivolatile organic compounds; high explosives; radiological constituents including depleted uranium

  12. Corrective Action Investigation Plan for Corrective Action Unit 140: Waste Dumps, Burn Pits, and Storage Area, Nevada Test Site, Nevada, July 2002, Rev. No. 0

    SciTech Connect

    NNSA /NV

    2002-07-18

    This Corrective Action Investigation Plan contains the U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office's approach to collect the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 140 under the Federal Facility Agreement and Consent Order. Corrective Action Unit 140 consists of nine Corrective Action Sites (CASs): 05-08-01, Detonation Pits; 05-08-02, Debris Pits; 05-17-01, Hazardous Waste Accumulation Site (Buried); 05-19-01, Waste Disposal Site; 05-23-01, Gravel Gertie; 05-35-01, Burn Pit; 05-99-04, Burn Pit; 22-99-04, Radioactive Waste Dump; 23-17-01, Hazardous Waste Storage Area. All nine of these CASs are located within Areas 5, 22, and 23 of the Nevada Test Site (NTS) in Nevada, approximately 65 miles northwest of Las Vegas. This CAU is being investigated because disposed waste may be present without appropriate controls (i.e., use restrictions, adequate cover) and hazardous and/or radioactive constituents may be present or migrating at concentrations and locations that could potentially pose a threat to human health and the environment. The NTS has been used for various research and development projects including nuclear weapons testing. The CASs in CAU 140 were used for testing, material storage, waste storage, and waste disposal. A two-phase approach has been selected to collect information and generate data to satisfy needed resolution criteria and resolve the decision statements. Phase I will determine if contaminants of potential concern (COPCs) are present in concentrations exceeding preliminary action levels. This data will be evaluated at all CASs. Phase II will determine the extent of the contaminant(s) of concern (COCs). This data will only be evaluated for CASs with a COC identified during Phase I. Based on process knowledge, the COPCs for CAU 140 include volatile organics, semivolatile organics, petroleum hydrocarbons, explosive residues

  13. Radioprotective cerium oxide nanoparticles: Molecular imaging investigations of conps' pharmacokinetics, efficacy, and mechanisms of action

    NASA Astrophysics Data System (ADS)

    McDonagh, Philip Reed Wills, III

    Cerium oxide nanoparticles (CONPs) are being investigated for several anti-oxidant applications in medicine. One of their most promising applications is as a radioprotective drug, an area of research in need due to the severe side effects from radiation therapy. In this work, the potential of CONPs as a radioprotective drug is examined using four criteria: favorable biodistribution/pharmacokinetics, low toxicity, ability to protect normal tissue from radiation damage, and lack of protection of tumor. The mechanisms of action of CONPs are also studied. Biodistribution was determined in radiolabeled CONPs with surface coatings including citrate, dextran T10-amine (DT10-NH2), dextran T10-polyethylene glycol (DT10-PEG), dextran T10-sulfobetaine (DT10-SB) and poly(acrylic acid) (PAA), and compared to uncoated. 89Zr was incorporated into CONPs for positron emission tomography (PET) imaging and ex vivo tissue analysis in tumor bearing mice. Compared to uncoated [ 89Zr]CONPs, coated [89Zr]CONPs showed improved biodistribution, including significantly enhanced renal clearance of PAA- [89Zr]CONPs. The toxicity of CONPs was evaluated in vitro and in vivo, with low toxicity at therapeutic doses. After clinically mimetic radiation therapy, pre-treatment of mice with coated and uncoated CONPs showed greater than 50% reduction of cell death in normal colon tissue, comparable to the clinically available radioprotective drug amifostine. Tumor control after irradiation of spontaneous colon tumors was unchanged with PAA-CONP pre-treatment, while citrate, DT10-PEG, and uncoated CONP pre-treatment had slightly less tumor control. Xenograft tumors were irradiated after pH normalizing treatment with sodium bicarbonate and PAA-CONP pre-treatment. Treatment of these tumors showed slightly less tumor control than irradiation alone or PAA-CONP plus irradiation, demonstrating that the acidic pH of the tumor microenvironment may be the basis of preventing CONPs' radioprotective properties in

  14. Corrective Action Investigation Plan for Corrective Action Unit 34: Area 3 Contaminated Waste Site, Nevada Test Site, Nevada (Rev. 0, March 2001)

    SciTech Connect

    U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office

    2001-03-27

    This Corrective Action Investigation Plan contains the U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office's approach to collect the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 34 under the Federal Facility Agreement and Consent Order. Corrective Action Unit 34 consists of four Corrective Action Sites (CASs). The CAU is located within the Area 3 Compound at the Nevada Test Site (NTS) in the vicinity of the Mud Plant Facility in Yucca Valley. Historically, CAS 03-09-07, Mud Pit, was used for disposal of excess mud from washing drilling equipment from 1968 to 1974, at which time it began to be used for excess mud disposal (currently inactive); CAS 03-44-01, Chromium Contamination Spill, was used to store additives used in the formulation of drilling mud from the early 1960s to the mid-1990s; CAS 03-47-02, Area 3 Mud Plant Pond, was used as a freshwater storage reservoir for the mud plant as well as supplied water for a number of activities including the mixing of mud, the rinsing and cleaning of tanks, and various washdowns from the 1960s through 1990s; and CAS 03-09-06, Mud Disposal Crater, was created in 1962 by an underground nuclear detonation (i.e., Chinchilla test) and was used to mix and store mud, dispose of receiving waste from the mud plant floor drains and excess drilling mud, and clean/flush mix tanks through the mid-1990s. Based on site history, the scope of this plan is to identify potentially contaminated ground soil at each of the four CASs and determine the quantity, nature, and extent of contaminants of potential concern (COPCs). The investigation will include systematic and biased surface and subsurface soil and mud sampling using hand-auguring and direct-push techniques; visual, video, and/or electromagnetic surveys of pipes; field screening for volatile organic compounds (VOCs) and alpha/beta-emitting radionuclides; and laboratory

  15. Corrective Action Investigation Plan for Corrective Action Unit 569: Area 3 Yucca Flat Atmospheric Test Sites Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews; Christy Sloop

    2012-02-01

    Corrective Action Unit (CAU) 569 is located in Area 3 of the Nevada National Security Site, which is approximately 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 569 comprises the nine numbered corrective action sites (CASs) and one newly identified site listed below: (1) 03-23-09, T-3 Contamination Area (hereafter referred to as Annie, Franklin, George, and Moth); (2) 03-23-10, T-3A Contamination Area (hereafter referred to as Harry and Hornet); (3) 03-23-11, T-3B Contamination Area (hereafter referred to as Fizeau); (4) 03-23-12, T-3S Contamination Area (hereafter referred to as Rio Arriba); (5) 03-23-13, T-3T Contamination Area (hereafter referred to as Catron); (6) 03-23-14, T-3V Contamination Area (hereafter referred to as Humboldt); (7) 03-23-15, S-3G Contamination Area (hereafter referred to as Coulomb-B); (8) 03-23-16, S-3H Contamination Area (hereafter referred to as Coulomb-A); (9) 03-23-21, Pike Contamination Area (hereafter referred to as Pike); and (10) Waste Consolidation Site 3A. Because CAU 569 is a complicated site containing many types of releases, it was agreed during the data quality objectives (DQO) process that these sites will be grouped. These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for each study group. The results of the field investigation will support a defensible evaluation of viable CAAs that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the DQOs developed on September 26, 2011, by representatives of the Nevada Division of Environmental Protection and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office. The DQO

  16. Corrective Action Investigation Plan for Corrective Action Unit 266: Area 25 Building 3124 Leachfield, Nevada Test Site, Nevada, Revision 1, February 1999

    SciTech Connect

    U.S. Department Of Energy, Nevada Operations Office

    1999-02-24

    The Corrective Action Investigation Plan for Corrective Action Unit 266, Area 25 Building 3124 Leachfield, has been developed in accordance with the Federal Facility Agreement and Consent Order that was agreed to by the U.S. Department of Energy, Nevada Operations Office; the State of Nevada Division of Environmental Protection; and the U.S. Department of Defense. Corrective Action Unit 266 consists of the Corrective Action Site 25-05-09 sanitary leachfield and associated collection system. This Corrective Action Investigation Plan is used in combination with the Work Plan for Leachfield Corrective Action Units: Nevada Test Site and Tonopah Test Range, Nevada (DOE/NV, 1998d). This Corrective Action Investigation Plan provides investigative details specific to Corrective Action Unit 266. Corrective Action Unit 266 is located southwest of Building 3124 which is located southwest and adjacent to Test Cell A. Test Cell A was operational during the 1960s to test nuclear rocket reactors in support of the Nuclear Rocket Development Station. Operations within Building 3124 from 1962 through the early 1990s resulted in effluent releases to the leachfield and associated collection system. The subsurface soils in the vicinity of the collection system and leachfield may have been impacted by effluent containing contaminants of potential concern generated by support activities associated with Test Cell A reactor testing operations, various laboratories including a high-level radioactivity environmental sample handling laboratory, and possibly the Treatability Test Facility. Based on site history collected to support the Data Quality Objectives process, contaminants of potential concern for the site include radionuclides, oil/diesel range total petroleum hydrocarbons, and Resource Conservation and Recovery Act characteristic volatile organic compounds, semivolatile organic compounds, and metals. Samples will also be analyzed for radionuclides and polychlorinated biphenyls not

  17. A FIB/TEM Study of a Complex Wark-Lovering Rim on a Vigarano CAI

    NASA Technical Reports Server (NTRS)

    Keller, L. P.; Needham, A. W.; Messenger, S.

    2013-01-01

    Wark-Lovering (WL) rims are thin multilayered mineral sequences that surround most Ca, Al-rich inclusions (CAIs). Several processes have been proposed for WL rim formation, including condensation, flash-heating or reaction with a nebular reservoir, or combinations of these [e.g. 1-7], but no consensus exists. Our previous coordinated transmission electron microscope (TEM) and NanoSIMS O isotopic measurements showed that a WL rim experienced flash heating events in a nebular environment with planetary O isotopic composition, distinct from the (16)O-rich formation environment [6]. Our efforts have focused on CAIs from the CV(sub red) chondrites, especially Vigarano, because these have escaped much of the parent body alteration effects that are common in CAIs from CV(sub ox) group.

  18. Corrective Action Investigation Plan for Corrective Action Unit 262: Area 25 Septic Systems and Underground Discharge Point, Nevada Test Site, Nevada, Revision No. 1 (9/2001)

    SciTech Connect

    NNSA /NV

    2000-07-20

    This corrective action investigation plan contains the U.S. Department of Energy, Nevada Operations Office's approach to collect data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 262 under the Federal Facility Agreement and Consent Order. Corrective Action Unit 262 consists of nine Corrective Action Sites (CASs): Underground Storage Tank (25-02-06), Septic Systems A and B (25-04-06), Septic System (25-04-07), Leachfield (25-05-03), Leachfield (25-05-05), Leachfield (25-05-06), Radioactive Leachfield (25-05-08), Leachfield (25-05-12), and Dry Well (25-51-01). Situated in Area 25 at the Nevada Test Site (NTS), sites addressed by CAU 262 are located at the Reactor-Maintenance, Assembly, and Disassembly (R-MAD); Test Cell C; and Engine-Maintenance, Assembly, and Disassembly (E-MAD) facilities. The R-MAD, Test Cell C, and E-MAD facilities supported nuclear rocket reactor and engine testing as part of the Nuclear Rocket Development Station. The activities associated with the testing program were conducted between 1958 and 1973. Based on site history collected to support the Data Quality Objectives process, contaminants of potential concern (COPCs) for the site include oil/diesel-range total petroleum hydrocarbons, volatile organic compounds, semivolatile organic compounds, polychlorinated biphenyls, Resource Conservation and Recovery Act metals, and gamma-emitting radionuclides, isotopic uranium, isotopic plutonium, strontium-90, and tritium. The scope of the corrective action field investigation at the CAU will include the inspection of portions of the collection systems, sampling the contents of collection system features in situ of leachfield logging materials, surface soil sampling, collection of samples of soil underlying the base of inlet and outfall ends of septic tanks and outfall ends of diversion structures and distribution boxes, collection of soil samples from biased or a combination of

  19. Corrective Action Investigation Plan for Corrective Action Unit 271: Areas 25, 26, and 27 Septic Systems, Nevada Test Site, Nevada (Rev. 0, April 2001)

    SciTech Connect

    U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office

    2001-04-09

    This Corrective Action Investigation Plan contains the U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office's approach to collect the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 271 under the Federal Facility Agreement and Consent Order. Corrective Action Unit 271 consists of 15 Corrective Action Sites (CASs) including: thirteen Septic Systems (25-04-01, 25-04-03, 25-04-04, 25-04-08, 25-04-09, 25-04-10, 25-04-11, 26-04-01, 26-04-02, 26-05-03, 26-05-04, 26-05-05, and 27-05-02), one Contaminated Water Reservoir (26-03-01), and one Radioactive Leachfield (26-05-01). The CASs addressed by CAU 271 are located at Guard Station 500, the Reactor Control Point (RCP), Bare Reactor Experiment - Nevada Tower, and Engine Test State-1 (ETS-1) facilities in Area 25; the Port Gaston and Project Pluto facilities in Area 26; and the Baker Site in Area 27 of the Nevada Test Site. Between 1 958 and 1973, the RCP and ETS-1 facilities supported the development and testing of nuclear reactors for space propulsion as part of the Nuclear Rocket Development Station. The Project Pluto facilities supported nuclear reactor testing for use as a ramjet propulsion system between 1961 and 1964, followed by similar use for other projects through the early 1980s. The Baker Site facilities were constructed in the 1960s to serve as the staging point where the manufactured components of nuclear devices were assembled, disassembled, and modified. The scope of the investigation strategy at these sites will involve biased and random soil sampling in leachfields using excavation (with drilling as a contingency), collection of soil samples underlying the base of proximal and distal ends of septic tanks and distal ends of distribution structures, defining the lateral and vertical extent of contamination through discrete field and possible stepout location sampling, collection system line

  20. Corrective Action Investigation Plan for Corrective Action Unit 567: Miscellaneous Soil Sites, Nevada National Security Site, Nevada, with ROTC 1 Revision 0

    SciTech Connect

    Matthews, Patrick K.

    2013-07-01

    Corrective Action Unit (CAU) 567 is located in Areas 1, 3, 5, 20, and 25 of the Nevada National Security Site, which is approximately 65 miles northwest of Las Vegas, Nevada. CAU 567 is a grouping of sites where there has been a suspected release of contamination associated with nuclear testing. This document describes the planned investigation of CAU 567, which comprises the following corrective action sites (CASs): • 01-23-03, Atmospheric Test Site T-1 • 03-23-25, Seaweed E Contamination Area • 05-23-07, A5b RMA • 20-23-08, Colby Mud Spill • 25-23-23, J-11 Soil RMA These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable CAAs that will be presented in the investigation report. The sites will be investigated based on the data quality objectives (DQOs) developed on May 6, 2013, by representatives of the Nevada Division of Environmental Protection and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Field Office. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 567. The site investigation process will also be conducted in accordance with the Soils Activity Quality Assurance Plan, which establishes requirements, technical planning, and general quality practices to be applied to this activity. The potential contamination sources associated with CAU 567 releases are nuclear test operations and other NNSS operations. The DQO process resulted in an assumption that total effective dose (TED) within a default contamination boundary

  1. Deriving High Resolution UV Aerosol Optical Depth over East Asia using CAI-OMI Joint Retrieval

    NASA Astrophysics Data System (ADS)

    Go, S.; Kim, J.; KIM, M.; Lee, S.

    2015-12-01

    Monitoring aerosols using near UV spectral region have been successfully performed over decades by Ozong Monitoring Instruments (OMI) with benefit of strong aerosol signal over continuous dark surface reflectance, both land and ocean. However, because of big foot print of OMI, the cloud contamination error was a big issue in the UV aerosol algorithm. In the present study, high resolution UV aerosol optical depth (AOD) over East Asia was derived by collaborating the Greenhouse gases Observing SATellite/Thermal And Near infrared Sensor for carbon Observation (GOSAT/TANSO)-Cloud and Aerosol Imager (CAI) and OMI together. AOD of 0.1 degree grid resolution was retrieved using CAI band 1 (380nm) by bring OMI lv.2 aerosol type, single scattering albedo, and aerosol layer peak height in 1 degree grid resolution. Collocation of the two dataset within the 0.5 degree grid with time difference of OMI and CAI less than 5 minute was selected. Selected region becomes wider as it goes to the higher latitude. Also, calculated degradation factor of 1.57 was applied to CAI band1 (380nm) by comparing normalized radiance and Lambertian Equivalent Reflectivity (LER) of both sensors. The calculated degradation factor was reasonable over dark scene, but inconsistent over cirrus cloud and bright area. Then, surface reflectance was developed by compositing CAI LER minimum data over three month period, since the infrequent sampling rate associated with the three-day recursion period of GOSAT and the narrow CAI swath of 1000 km. To retrieve AOD, look up table (LUT) was generated using radiative transfer model VLIDORT NGST. Finally, the retrieved AOD was validated with AERONET ground based measurement data during the Dragon-NE Asia campaign in 2012.

  2. Verification of new cloud discrimination algorithm using GOSAT TANSO-CAI in the Amazon

    NASA Astrophysics Data System (ADS)

    Oishi, Y.; Ishida, H.; Nakajima, T. Y.

    2015-12-01

    Greenhouse gases Observing SATellite (GOSAT) was launched in 2009 to measure the global atmospheric CO2 and CH4 concentrations. GOSAT is equipped with two sensors: the Thermal And Near-infrared Sensor for carbon Observation-Fourier Transform Spectrometer (TANSO-FTS) and the Cloud and Aerosol Imager (TANSO-CAI). The presence of clouds in the instantaneous field-of-view (IFOV) of the FTS leads to incorrect estimates of the concentrations. Thus, the FTS data which are suspected to be cloud-contaminated must be identified using a CAI cloud discrimination algorithm and rejected. Conversely, overestimation of clouds leads to reduce the amount of the FTS data which can be used to estimate the greenhouse gases concentrations. It becomes a serious problem in the region of tropical rainforest such as the Amazon, where there are very few remaining FTS data by cloud cover. The preparation for the launch of the GOSAT-2 in fiscal 2017 has been progressing. To improve the accuracy of estimates of the greenhouse gases concentrations, we need to refine the existing CAI cloud discrimination algorithm. For the reason, a new cloud discrimination algorithm using support vector machines (SVM) was developed. Visual inspections can use the locally optimized thresholds, though the existing CAI cloud discrimination algorithm uses the common thresholds all over the world. Thus, it is certain that the accuracy of visual inspections is better than these algorithms in the limited region without areas such as ice and snow, where it is difficult to discriminate between clouds and ground surfaces. In this study we evaluated the accuracy of the new cloud discrimination algorithm by comparing with the existing CAI cloud discrimination algorithm and visual inspections of the same CAI images in the Amazon. We will present our latest results.

  3. Oxygen reservoirs in the early solar nebula inferred from an allende CAI

    PubMed

    Young; Russell

    1998-10-16

    Ultraviolet laser microprobe analyses of a calcium-aluminum-rich inclusion (CAI) from the Allende meteorite suggest that a line with a slope of exactly 1.00 on a plot of delta17O against delta18O represents the primitive oxygen isotope reservoir of the early solar nebula. Most meteorites are enriched in 17O and 18O relative to this line, and their oxygen isotope ratios can be explained by mass fractionation or isotope exchange initiating from the primitive reservoir. These data establish a link between the oxygen isotopic composition of the abundant ordinary chondrites and the primitive 16O-rich component of CAIs.

  4. Oxygen reservoirs in the early solar nebula inferred from an Allende CAI.

    PubMed

    Young, E D; Russell, S S

    1998-10-16

    Ultraviolet laser microprobe analyses of a calcium-aluminum-rich inclusion (CAI) from the Allende meteorite suggest that a line with a slope of exactly 1.00 on a plot of delta (17)O against delta (18)O represents the primitive oxygen isotope reservoir of the early solar nebula. Most meteorites are enriched in (17)O and (18)O relative to this line, and their oxygen isotope ratios can be explained by mass fractionation or isotope exchange initiating from the primitive reservoir. These data establish a link between the oxygen isotopic composition of the abundant ordinary chondrites and the primitive (16)O-rich component of CAIs.

  5. Corrective Action Investigation Plan for Corrective Action Unit 104: Area 7 Yucca Flat Atmospheric Test Sites, Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews

    2011-08-01

    CAU 104 comprises the 15 CASs listed below: (1) 07-23-03, Atmospheric Test Site T-7C; (2) 07-23-04, Atmospheric Test Site T7-1; (3) 07-23-05, Atmospheric Test Site; (4) 07-23-06, Atmospheric Test Site T7-5a; (5) 07-23-07, Atmospheric Test Site - Dog (T-S); (6) 07-23-08, Atmospheric Test Site - Baker (T-S); (7) 07-23-09, Atmospheric Test Site - Charlie (T-S); (8) 07-23-10, Atmospheric Test Site - Dixie; (9) 07-23-11, Atmospheric Test Site - Dixie; (10) 07-23-12, Atmospheric Test Site - Charlie (Bus); (11) 07-23-13, Atmospheric Test Site - Baker (Buster); (12) 07-23-14, Atmospheric Test Site - Ruth; (13) 07-23-15, Atmospheric Test Site T7-4; (14) 07-23-16, Atmospheric Test Site B7-b; (15) 07-23-17, Atmospheric Test Site - Climax These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable CAAs that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on April 28, 2011, by representatives of the Nevada Division of Environmental Protection and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 104. The releases at CAU 104 consist of surface-deposited radionuclides from 30 atmospheric nuclear tests. The presence and nature of contamination at CAU 104 will be evaluated based on information collected from a field investigation. Radiological contamination will be evaluated based on a comparison

  6. An in vitro investigation into the cutting action of ultrasonic radicular access preparation instruments.

    PubMed

    Waplington, M; Lumley, P J; Blunt, L

    2000-08-01

    The aim of this study was to investigate the dentine cutting action of a CT4 and SJ4 radicular preparation inserts (Excellence in Endodontics/Analytic Technology, Orange, CA, USA) used in a Piezon Master 400 ultrasonic handpiece (Electro Medical Systems SA, Nyon, Switzerland). Calibration of the ultrasonic inserts was carried out at minimum, medium and maximum power settings using light microscopic measurement of the tip displacement amplitudes (x120 mag). Polished dentine samples were instrumented, at monitored loads, at the three chosen power settings, to produce uniform dentine cuts. The resultant dentine debris was collected for SEM analysis, and comparison with that produced by rotary instruments. The depth of dentine cut was measured at x30 magnification. Fracture of the SJ4 insert was noted at medium power setting. Results revealed a significant increase in both displacement amplitude and depth of dentine cut with power setting (ANOVA P < 0.001). Dentine chip size increased with power, and differed in structure and appearance from those produced by rotary instruments. In conclusion, ultrasonic cutting is influenced significantly by power setting, and dentine chip formation is fundamentally different to rotary instrumentation.

  7. An integrated approach for prospectively investigating a mode-of-action for rodent liver effects.

    PubMed

    LeBaron, Matthew J; Geter, David R; Rasoulpour, Reza J; Gollapudi, B Bhaskar; Thomas, Johnson; Murray, Jennifer; Kan, H Lynn; Wood, Amanda J; Elcombe, Cliff; Vardy, Audrey; McEwan, Jillian; Terry, Claire; Billington, Richard

    2013-07-15

    Registration of new plant protection products (e.g., herbicide, insecticide, or fungicide) requires comprehensive mammalian toxicity evaluation including carcinogenicity studies in two species. The outcome of the carcinogenicity testing has a significant bearing on the overall human health risk assessment of the substance and, consequently, approved uses for different crops across geographies. In order to understand the relevance of a specific tumor finding to human health, a systematic, transparent, and hypothesis-driven mode of action (MoA) investigation is, appropriately, an expectation by the regulatory agencies. Here, we describe a novel approach of prospectively generating the MoA data by implementing additional end points to the standard guideline toxicity studies with sulfoxaflor, a molecule in development. This proactive MoA approach results in a more robust integration of molecular with apical end points while minimizing animal use. Sulfoxaflor, a molecule targeting sap-feeding insects, induced liver effects (increased liver weight due to hepatocellular hypertrophy) in an initial palatability probe study for selecting doses for subsequent repeat-dose dietary studies. This finding triggered the inclusion of dose-response investigations of the potential key events for rodent liver carcinogenesis, concurrent with the hazard assessment studies. As predicted, sulfoxaflor induced liver tumors in rats and mice in the bioassays. The MoA data available by the time of the carcinogenicity finding supported the conclusion that the carcinogenic potential of sulfoxaflor was due to CAR/PXR nuclear receptor activation with subsequent hepatocellular proliferation. This MoA was not considered to be relevant to humans as sulfoxaflor is unlikely to induce hepatocellular proliferation in humans and therefore would not be a human liver carcinogen.

  8. Record of Technical Change {number_sign}2 for ''Corrective Action Investigation Plan for Corrective Action Unit 261: Test Cell A Leachfield System, Nevada Test Site, Nevada,'' Revision 0

    SciTech Connect

    US DOE Nevada Operations Office

    2000-06-08

    This Record of Technical Change updates the technical information included in ''Corrective Action Investigation Plan for Corrective Action Unit 261: Test Cell A Leachfield System, Nevada Test Site, Nevada,'' Revision 0, DOE/NV--515.

  9. Record of Technical Change {number_sign}1 to ''Corrective Action Investigation Plan for Corrective Action Unit 261: Test Cell A Leachfield System, Nevada Test Site, Nevada,'' Revision 0, DOE/NV-519

    SciTech Connect

    US DOE Nevada Operations Office

    2000-02-25

    This Record of Technical Change provides updates to the technical information included in ''Corrective Action Investigation Plan for Corrective Action Unit 261: Test Cell A Leachfield System, Nevada Test Site, Nevada,'' DOE/NV--519.

  10. Exploring the Utility of Action Research to Investigate Second-Language Classrooms as Complex Systems

    ERIC Educational Resources Information Center

    Ahmadian, Mohammad Javad; Tavakoli, Mansoor

    2011-01-01

    Action research is geared to changes for the better and has the potential to assist teachers to extend their teaching skills and develop a deeper understanding of themselves, their classroom and their learners. However, in the area of applied linguistics, the viability of action research has been seriously questioned. In this article, we argue…

  11. Development of an in vitro Hepatocyte Model to Investigate Chemical Mode of Action

    EPA Science Inventory

    There is a clear need to identify and characterize the potential of liver in vitro models that can be used to replace animals for mode of action analysis. Our goal is to use in vitro models for mode of action prediction which recapitulate critical cellular processes underlying in...

  12. An Investigation of Preschool Teachers' Ways of Seeing Action Research Using Phenomenography

    ERIC Educational Resources Information Center

    Lam, Ho Cheong

    2016-01-01

    One of the purposes of introducing the use of action research in schools is to bring about educational change in policy and practice. To make this happen, it is of paramount importance to look into how teachers actually see action research. We, the writers of this paper, are teacher educators, teaching preschool teachers courses related to action…

  13. Action planning as predictor of health protective and health risk behavior: an investigation of fruit and snack consumption

    PubMed Central

    van Osch, Liesbeth; Beenackers, Mariëlle; Reubsaet, Astrid; Lechner, Lilian; Candel, Math; de Vries, Hein

    2009-01-01

    Background Large discrepancies between people's intention to eat a healthy diet and actual dietary behavior indicate that motivation is not a sufficient instigator for healthy behavior. Research efforts to decrease this 'intention - behavior gap' have centered on aspects of self-regulation, most importantly self-regulatory planning. Most studies on the impact of self-regulatory planning in health and dietary behavior focus on the promotion of health protective behaviors. This study investigates and compares the predictive value of action planning in health protective behavior and the restriction of health risk behavior. Methods Two longitudinal observational studies were performed simultaneously, one focusing on fruit consumption (N = 572) and one on high-caloric snack consumption (N = 585) in Dutch adults. Structural equation modeling was used to investigate and compare the predictive value of action planning in both behaviors, correcting for demographics and the influence of motivational factors and past behavior. The nature of the influence of action planning was investigated by testing mediating and moderating effects. Results Action planning was a significant predictor of fruit consumption and restricted snack consumption beyond the influence of motivational factors and past behavior. The strength of the predictive value of action planning did not differ between the two behaviors. Evidence for mediation of the intention - behavior relationship was found for both behaviors. Positive moderating effects of action planning were demonstrated for fruit consumption, indicating that individuals who report high levels of action planning are significantly more likely to translate their intentions into actual behavior. Conclusion The results indicate that the planning of specific preparatory actions predicts the performance of healthy dietary behavior and support the application of self-regulatory planning in both health protective and health risk behaviors. Future

  14. Stable Magnesium Isotope Variation in Melilite Mantle of Allende Type B1 CAI EK 459-5-1

    NASA Technical Reports Server (NTRS)

    Kerekgyarto, A. G.; Jeffcoat, C. R.; Lapen, T. J.; Andreasen, R.; Righter, M.; Ross, D. K.

    2014-01-01

    Ca-Al-rich inclusions (CAIs) are the earliest formed crystalline material in our solar system and they record early Solar System processes. Here we present petrographic and delta Mg-25 data of melilite mantles in a Type B1 CAI that records early solar nebular processes.

  15. The Matriculation Science Curriculum of the USM in the Context of the PPI and CAI Modes of Instruction.

    ERIC Educational Resources Information Center

    Cheng, Chuah Chong; Seng, Chin Pin

    1985-01-01

    Discusses philosophy, aims and objectives, and structure of the Matriculation Science Curriculum of the University Sains Malaysia. Includes comments on instructional strategies, individualized learning, programmed instruction, systems approach to computer-assisted instruction (CAI) implementation, CAI authoring system, and various program…

  16. Gender Role, Gender Identity and Sexual Orientation in CAIS ("XY-Women") Compared With Subfertile and Infertile 46,XX Women.

    PubMed

    Brunner, Franziska; Fliegner, Maike; Krupp, Kerstin; Rall, Katharina; Brucker, Sara; Richter-Appelt, Hertha

    2016-01-01

    The perception of gender development of individuals with complete androgen insensitivity syndrome (CAIS) as unambiguously female has recently been challenged in both qualitative data and case reports of male gender identity. The aim of the mixed-method study presented was to examine the self-perception of CAIS individuals regarding different aspects of gender and to identify commonalities and differences in comparison with subfertile and infertile XX-chromosomal women with diagnoses of Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) and polycystic ovary syndrome (PCOS). The study sample comprised 11 participants with CAIS, 49 with MRKHS, and 55 with PCOS. Gender identity was assessed by means of a multidimensional instrument, which showed significant differences between the CAIS group and the XX-chromosomal women. Other-than-female gender roles and neither-female-nor-male sexes/genders were reported only by individuals with CAIS. The percentage with a not exclusively androphile sexual orientation was unexceptionally high in the CAIS group compared to the prevalence in "normative" women and the clinical groups. The findings support the assumption made by Meyer-Bahlburg ( 2010 ) that gender outcome in people with CAIS is more variable than generally stated. Parents and professionals should thus be open to courses of gender development other than typically female in individuals with CAIS.

  17. Revision of the Oriental leafhopper genus Destinoides Cai & He (Hemiptera: Cicadellidae: Ledrinae), with a new synonym and two new combinations.

    PubMed

    Sun, Jing; Webb, Michael D; Zhang, Yalin

    2014-01-01

    The leafhopper genus Destinoides Cai & He is revised to include two species D. latifrons (Walker 1851, Ledra) n. comb. and D. conspicuus (Distant 1907, Petalocephala) n. comb. Destinoides fasciata Cai & He, 2000 is placed as a junior synonym of D. latifrons, syn. nov. These two species are redescribed and illustrated in detail and a key is given based on the males.

  18. Corrective Action Investigation Plan for Corrective Action Unit 230: Area 22 Sewage Lagoons and Corrective Action Unit 320: Area 22 Desert Rock Airport Strainer Box, Nevada Test Site, Nevada

    SciTech Connect

    US DOE /Nevada Operations Office

    1999-06-10

    This Corrective Action Investigation Plan contains the U.S. Department of Energy, Nevada Operation Office's approach to collect the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 230/320 under the Federal Facility Agreement and Consent Order. Corrective Action Unit 230 consists of Corrective Action Site (CAS) 22-03-01, Sewage Lagoon; while CAU 320 consists of CAS 22-99-01, Strainer Box. These CAUs are referred to as CAU 230/320 or the Sewage Lagoons Site. The Sewage Lagoons Site also includes an Imhoff tank, sludge bed, and associated buried sewer piping. Located in Area 22, the site was used between 1951 to 1958 for disposal of sanitary sewage effluent from the historic Camp Desert Rock Facility at the Nevada Test Site in Nevada. Based on site history, the contaminants of potential concern include volatile organic compounds (VOCs), semivolatile organic compounds, total petroleum hydrocarbons (TPH), and radionuclides. Vertical migration is estimated to be less than 12 feet below ground surface, and lateral migration is limited to the soil immediately adjacent to or within areas of concern. The proposed investigation will involve a combination of field screening for VOCs and TPH using the direct-push method and excavation using a backhoe to gather soil samples for analysis. Gamma spectroscopy will also be conducted for waste management purposes. Sampling locations will be biased to suspected worst-case areas including the nearby sludge bed, sewage lagoon inlet(s) and outlet(s), disturbed soil surrounding the lagoons, surface drainage channel south of the lagoons, and the area near the Imhoff tank. The results of this field investigation will support a defensible evaluation of corrective action alternatives in the corrective action decision document.

  19. Corrective Action Investigation Plan for Corrective Action Unit 230: Area 22 Sewage Lagoons and Corrective Action Unit 320: Area 22 Desert Rock Air port Strainer Box, Nevada Test Site, Nevada

    SciTech Connect

    U.S. Department of Energy, Nevada Operations Office

    1999-06-10

    This Corrective Action Investigation Plan contains the US Department of Energy, Nevada Operation Office's approach to collect the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 230/320 under the Federal Facility Agreement and Consent Order. Corrective Action Unit 230 consists of Corrective Action Site (CAS) 22-03-01, Sewage Lagoon; while CAU 320 consists of CAS 22-99-01, Strainer Box. These CAUs are referred to as CAU 230/320 or the Sewage Lagoons Site. The Sewage Lagoons Site also includes an Imhoff tank, sludge bed, and associated buried sewer piping. Located in Area 22, the site was used between 1951 to 1958 for disposal of sanitary sewage effluent from the historic Camp Desert Rock Facility at the Nevada Test Site in Nevada. Based on site history, the contaminants of potential concern include volatile organic compounds (VOCs), semivolatile organic compounds, total petroleum hydrocarbons (TPH), and radionuclides. Vertical migration is estimated to be less than 12 feet below ground surface, and lateral migration is limited to the soil immediately adjacent to or within areas of concern. The proposed investigation will involve a combination of field screening for VOCs and TPH using the direct-push method and excavation using a backhoe to gather soil samples for analysis. Gamma spectroscopy will also be conducted for waste management purposes. Sampling locations will be biased to suspected worst-case areas including the nearby sludge bed, sewage lagoon inlet(s) and outlet(s), disturbed soil surrounding the lagoons, surface drainage channel south of the lagoons, and the area near the Imhoff tank. The results of this field investigation will support a defensible evaluation of corrective action alternatives in the corrective action decision document.

  20. Corrective Action Decision Document/Closure Report for Corrective Action Unit 105: Area 2 Yucca Flat Atmospheric Test Sites, Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Matthews, Patrick

    2013-09-01

    This Corrective Action Decision Document/Closure Report presents information supporting the closure of Corrective Action Unit (CAU) 105: Area 2 Yucca Flat Atmospheric Test Sites, Nevada National Security Site, Nevada. CAU 105 comprises the following five corrective action sites (CASs): -02-23-04 Atmospheric Test Site - Whitney Closure In Place -02-23-05 Atmospheric Test Site T-2A Closure In Place -02-23-06 Atmospheric Test Site T-2B Clean Closure -02-23-08 Atmospheric Test Site T-2 Closure In Place -02-23-09 Atmospheric Test Site - Turk Closure In Place The purpose of this Corrective Action Decision Document/Closure Report is to provide justification and documentation supporting the recommendation that no further corrective action is needed for CAU 105 based on the implementation of the corrective actions. Corrective action investigation (CAI) activities were performed from October 22, 2012, through May 23, 2013, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 105: Area 2 Yucca Flat Atmospheric Test Sites; and in accordance with the Soils Activity Quality Assurance Plan, which establishes requirements, technical planning, and general quality practices.

  1. Corrective Action Investigation Plan for Corrective Action Unit 545: Dumps, Waste Disposal Sites, and Buried Radioactive Materials Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Wickline, Alfred

    2007-06-01

    Corrective Action Unit 545, Dumps, Waste Disposal Sites, and Buried Radioactive Materials, consists of seven inactive sites located in the Yucca Flat area and one inactive site in the Pahute Mesa area. The eight CAU 545 sites consist of craters used for mud disposal, surface or buried waste disposed within craters or potential crater areas, and sites where surface or buried waste was disposed. The CAU 545 sites were used to support nuclear testing conducted in the Yucca Flat area during the 1950s through the early 1990s, and in Area 20 in the mid-1970s. This Corrective Action Investigation Plan has been developed in accordance with the Federal Facility Agreement and Consent Order that was agreed to by the State of Nevada, the U.S. Department of Energy, and the U.S. Department of Defense. Under the Federal Facility Agreement and Consent Order, this Corrective Action Investigation Plan will be submitted to the Nevada Division of Environmental Protection for approval. Fieldwork will be conducted following approval.

  2. [CAIS correction for blood matrix effect on determination of lead concentration and isotope ratio by ICP-MS].

    PubMed

    Zeng, Jing; Wang, Xiao-yan; Liu, Hu-sheng; Dun, Zhe; Zhai, Lei; Wang, Jing-yu

    2007-02-01

    The research studied the influence of matrix effect on the determination of lead concentration and isotope ratio through simulating blood matrix, and its correction by common analyte internal standardization (CAIS) method. The experiment results showed that CAIS method was suitable for the multi-element-matrix. The relative errors between the determined and the true concentration values are 20% (without correction), 8% (by conventional internal reference correction) and 2% (by CAIS correction), respectively. Otherwise, the influence of matrix effect and its correction for isotope ratio determination are not that obvious. Similarity of the mass number and properties between internal reference and analyte elements seems not important for CAIS correction, since very close correction results were obtained by using Tl and Dy as internal reference elements. Besides, correction results are not affected by different matrix dilution. Reliability and practicality of CAIS were proved by bovine blood standard material determination.

  3. Investigating stability using nonlinear quasihomogeneous approximation to differential equations with impulsive action

    SciTech Connect

    Dvirny, A. I.; Slyn'ko, V. I. E-mail: vitstab@ukr.net

    2014-06-01

    Inverse theorems to Lyapunov's direct method are established for quasihomogeneous systems of differential equations with impulsive action. Conditions for the existence of Lyapunov functions satisfying typical bounds for quasihomogeneous functions are obtained. Using these results, we establish conditions for an equilibrium of a nonlinear system with impulsive action to be stable, using the properties of a quasihomogeneous approximation to the system. The results are illustrated by an example of a large-scale system with homogeneous subsystems. Bibliography: 30 titles. (paper)

  4. An integrated approach for prospectively investigating a mode-of-action for rodent liver effects

    SciTech Connect

    LeBaron, Matthew J.; Geter, David R.; Rasoulpour, Reza J.; Gollapudi, B. Bhaskar; Thomas, Johnson; Murray, Jennifer; Kan, H. Lynn; Wood, Amanda J.; Elcombe, Cliff; Vardy, Audrey; McEwan, Jillian; Terry, Claire; Billington, Richard

    2013-07-15

    Registration of new plant protection products (e.g., herbicide, insecticide, or fungicide) requires comprehensive mammalian toxicity evaluation including carcinogenicity studies in two species. The outcome of the carcinogenicity testing has a significant bearing on the overall human health risk assessment of the substance and, consequently, approved uses for different crops across geographies. In order to understand the relevance of a specific tumor finding to human health, a systematic, transparent, and hypothesis-driven mode of action (MoA) investigation is, appropriately, an expectation by the regulatory agencies. Here, we describe a novel approach of prospectively generating the MoA data by implementing additional end points to the standard guideline toxicity studies with sulfoxaflor, a molecule in development. This proactive MoA approach results in a more robust integration of molecular with apical end points while minimizing animal use. Sulfoxaflor, a molecule targeting sap-feeding insects, induced liver effects (increased liver weight due to hepatocellular hypertrophy) in an initial palatability probe study for selecting doses for subsequent repeat-dose dietary studies. This finding triggered the inclusion of dose-response investigations of the potential key events for rodent liver carcinogenesis, concurrent with the hazard assessment studies. As predicted, sulfoxaflor induced liver tumors in rats and mice in the bioassays. The MoA data available by the time of the carcinogenicity finding supported the conclusion that the carcinogenic potential of sulfoxaflor was due to CAR/PXR nuclear receptor activation with subsequent hepatocellular proliferation. This MoA was not considered to be relevant to humans as sulfoxaflor is unlikely to induce hepatocellular proliferation in humans and therefore would not be a human liver carcinogen. - Highlights: • We prospectively generated MoA data into standard guideline toxicity studies. • A proactive MoA approach

  5. Real-Time Graphics for CAI: A Rudimentary Grammar and Demonstration Program.

    ERIC Educational Resources Information Center

    Winn, William

    This paper focuses on graphics and how they can be created, in real time, from information stored in a database, and the application of this technique to computer-assisted instruction (CAI). It is noted that this is a special case of the general trend towards endowing instructional systems with a degree of decision-making or design expertise, as…

  6. Role of Computer Assisted Instruction (CAI) in an Introductory Computer Concepts Course.

    ERIC Educational Resources Information Center

    Skudrna, Vincent J.

    1997-01-01

    Discusses the role of computer assisted instruction (CAI) in undergraduate education via a survey of related literature and specific applications. Describes an undergraduate computer concepts course and includes appendices of instructions, flowcharts, programs, sample student work in accounting, COBOL instructional model, decision logic in a…

  7. Toward a Market Success for CAI; An Overview of the TICCIT Program.

    ERIC Educational Resources Information Center

    Stetten, Kenneth J.

    A new computer-assisted instruction (CAI) system for college teaching is being tested in two locations by the MITRE Corporation. The system, called TICCIT (Time-Share Interactive Computer-Controlled Information Television), now interacts with more than 100 students, each moving at his own pace, for four semesters of community college math and…

  8. Effectiveness of Computer Assisted Instructions (CAI) in Teaching of Mathematics at Secondary Level

    NASA Astrophysics Data System (ADS)

    Dhevakrishnan, R.; Devi, S.; Chinnaiyan, K.

    2012-09-01

    The present study was aimed at effectiveness of computer assisted instructions (CAI) in teaching of mathematics at secondary level adopted experimental method and observing the difference between (CAI) and traditional method. A sample of sixty (60) students of IX class in VVB Matriculation Higher Secondary School at Elayampalayam, Namakkal district were selected for a sample and sample was divided into two group namely experiment and control group. The experimental group consisted 30 students who were taught 'Mensurationí by the computer assisted instructions and the control groups comprising 30 students were taught by the conventional method of teaching. Data analyzed using mean, S.D. and t-test. Findings of the study clearly point out that significant increase in the mean gain scores has been found in the post test scores of the experimental group. Significant differences have been found between the control group and experimental group on post test gain scores. The experiment group, which was taught by the CAI showed better, learning. The conclusion is evident that the CAI is an effective media of instruction for teaching Mathematics at secondary students.s

  9. Web Pages: An Effective Method of Providing CAI Resource Material in Histology.

    ERIC Educational Resources Information Center

    McLean, Michelle

    2001-01-01

    Presents research that introduces computer-aided instruction (CAI) resource material as an integral part of the second-year histology course at the University of Natal Medical School. Describes the ease with which this software can be developed, using limited resources and available skills, while providing students with valuable learning…

  10. The Development and Utilization of Mobile CAI for the Education of Nurses in Remote Areas.

    ERIC Educational Resources Information Center

    Hall, Keith A.

    In providing for inservice nursing educational opportunities, the obvious advantages of the computer-assisted instruction (CAI) mobile system are its inherent interactive quality and the flexibility of scheduling made available to those who are already working in a field. The rationale for the development of the system is based on the past and…

  11. The Role of the CAI-1 Fatty Acid Tail in the Vibrio cholerae Quorum Sensing Response

    PubMed Central

    Perez, Lark J.; Ng, Wai-Leung; Marano, Paul; Brook, Karolina; Bassler, Bonnie L.; Semmelhack, Martin F.

    2013-01-01

    Quorum sensing is a mechanism of chemical communication among bacteria that enables collective behaviors. In V. cholerae, the etiological agent of the disease cholera, quorum sensing controls group behaviors including virulence factor production and biofilm formation. The major V. cholerae quorum-sensing system consists of the extracellular signal molecule called CAI-1 and its cognate membrane bound receptor called CqsS. Here, the ligand binding activity of CqsS is probed with structural analogs of the natural signal. Enabled by our discovery of a structurally simplified analog of CAI-1, we prepared and analyzed a focused library. The molecules were designed to probe the effects of conformational and structural changes along the length of the fatty acid tail of CAI-1. Our results, combined with pharmacophore modeling, suggest a molecular basis for signal molecule recognition and receptor fidelity with respect to the fatty acid tail portion of CAI-1. These efforts provide novel probes to enhance discovery of anti-virulence agents for the treatment of V. cholerae. PMID:23092313

  12. Assessing the Impact of Computer-Assisted Instruction (CAI) in Undergraduate Latin American Studies.

    ERIC Educational Resources Information Center

    Child, Jack

    This paper assesses the impact of using computer-assisted instruction (CAI) in three American University undergraduate classes, a General Education survey course on Latin America (taught in English), and two Spanish language courses. The courses utilized both commercial software programs and software programs authored by faculty using Macintosh…

  13. On the Design and Development of Pedagogy-First CAI Tools for CS Education.

    ERIC Educational Resources Information Center

    Vadaparty, K.; And Others

    This paper presents the implications of an ongoing project on the design and development of multimedia instructional material for teaching and learning computer science topics at both graduate and undergraduate levels. Important pedagogical requirements that CAI software should satisfy include: (1) animation of the changes in tree topologies; (2)…

  14. Development of a Computer-Assisted Instruction (CAI) Program on the Delphi Technique.

    ERIC Educational Resources Information Center

    McCurdy, Carol

    The concept of Delphi technique was presented in a computer-assisted instruction (CAI) module designed for educational administration classes or inservice training of administrators. Instructional Dialogue Facility (IDF) Author Language on a 2000F Hewlett-Packard time-sharing system was used to write the sequence. Instructional objectives,…

  15. Consumption of fa cai Nostoc soup: a potential for BMAA exposure from Nostoc cyanobacteria in China?

    PubMed

    Roney, Britton R; Renhui, Li; Banack, Sandra Anne; Murch, Susan; Honegger, Rosmarie; Cox, Paul Alan

    2009-01-01

    Grown in arid regions of western China the cyanobacterium Nostoc flagelliforme--called fa cai in Mandarin and fat choy in Cantonese--is wild-harvested and used to make soup consumed during New Year's celebrations. High prices, up to $125 USD/kg, led to overharvesting in Inner Mongolia, Ningxia, Gansu, Qinghai, and Xinjiang. Degradation of arid ecosystems, desertification, and conflicts between Nostoc harvesters and Mongol herdsmen concerned the Chinese environmental authorities, leading to a government ban of Nostoc commerce. This ban stimulated increased marketing of a substitute made from starch. We analysed samples purchased throughout China as well as in Chinese markets in the United States and the United Kingdom. Some were counterfeits consisting of dyed starch noodles. A few samples from California contained Nostoc flagelliforme but were adulterated with starch noodles. Other samples, including those from the United Kingdom, consisted of pure Nostoc flagelliforme. A recent survey of markets in Cheng Du showed no real Nostoc flagelliforme to be marketed. Real and artificial fa cai differ in the presence of beta-N-methylamino-L-alanine (BMAA). Given its status as a high-priced luxury food, the government ban on collection and marketing, and the replacement of real fa cai with starch substitutes consumed only on special occasions, it is anticipated that dietary exposure to BMAA from fa cai will be reduced in the future in China.

  16. A Cross-National CAI Tool To Support Learning Operations Decision-Making and Market Analysis.

    ERIC Educational Resources Information Center

    Mockler, Robert J.; Afanasiev, Mikhail Y.; Dologite, Dorothy G.

    1999-01-01

    Describes bicultural (United States and Russia) development of a computer-aided instruction (CAI) tool to learn management decision-making using information systems technologies. The program has been used with undergraduate and graduate students in both countries; it integrates free and controlled market concepts and combines traditional computer…

  17. Computer-Assisted Instruction in Engineering Dynamics. CAI-Systems Memo Number 18.

    ERIC Educational Resources Information Center

    Sheldon, John W.

    A 90-minute computer-assisted instruction (CAI) unit course supplemented by a 1-hour lecture on the dynamic nature of three-dimensional rotations and Euler angles was given to 29 undergraduate engineering students. The area of Euler angles was selected because it is essential to problem-working in three-dimensional rotations of a rigid body, yet…

  18. An ion microprobe study of CAIs from CO3 meteorites. [Abstract only

    NASA Technical Reports Server (NTRS)

    Russell, S. S.; Greenwood, R. C.; Fahey, A. J.; Huss, G. R.; Wasserburg, G. J.

    1994-01-01

    When attempting to interpret the history of Ca, Al-rich inclusions (CAIs) it is often difficult to distinguish between primary features inherited from the nebula and those produced during secondary processing on the parent body. We have undertaken a systematic study of CAIs from 10 CO chondrites, believed to represent a metamorphic sequence with the goal of distinguishing primary and secondary features. ALHA 77307 (3.0), Colony (3.0), Kainsaz (3.1), Felix (3.2), ALH 82101 (3.3), Ornans (3.3), Lance (3.4), ALHA 77003 (3.5), Warrenton (3.6), and Isna (3.7) were examined by Scanning Electron Microscopy (SEM) and optical microscopy. We have identified 141 CAIs within these samples, and studied in detail the petrology of 34 inclusions. The primary phases in the lower petrologic types are spinel, melilite, and hibonite. Perovskite, FeS, ilmenite, anorthite, kirschsteinite, and metallic Fe are present as minor phases. Melilite becomes less abundant in higher petrologic types and was not detected in chondrites of type 3.5 and above, confirming previous reports that this mineral easily breaks down during heating. Iron, an element that would not be expected to condense at high temperatures, has a lower abundance in spinel from low-petrologic-type meteorites than those of higher grade, and CaTiO3 is replaced by FeTiO3 in meteorites of higher petrologic type. The abundance of CAIs is similar in each meteorite. Eight inclusions have been analyzed by ion probe. The results are summarized. The results obtained to date show that CAIs in CO meteorites, like those from other meteorite classes, contain Mg* and that Mg in some inclusions has been redistributed.

  19. Corrective Action Investigation Plan for Corrective Action Unit 127: Areas 25 and 26 Storage Tanks, Nevada Test Site, Nevada (Rev. No.: 0, August 2002)

    SciTech Connect

    NNSA /NV

    2002-08-27

    This Corrective Action Investigation Plan (CAIP) contains the U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Offices's approach to collect the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 127 under the Federal Facility Agreement and Consent Order. Corrective Action Unit 127 is located on the Nevada Test Site approximately 65 miles northwest of Las Vegas, Nevada. This CAU is comprised of 12 Corrective Action Sites (CASs) located at Test Cell C; the Engine Maintenance, Assembly, and Disassembly (E-MAD) Facility; the X-Tunnel in Area 25; the Pluto Disassembly Facility; the Pluto Check Station; and the Port Gaston Training Facility in Area 26. These CASs include: CAS 25-01-05, Aboveground Storage Tank (AST); CAS 25-02-02, Underground Storage Tank (UST); CAS 25-23-11, Contaminated Materials; CAS 25-12-01, Boiler; CAS 25-01-06, AST; CAS 25-01-07, AST; CAS 25-02-13, UST; CAS 26- 01-01, Filter Tank (Rad) and Piping; CAS 26-01-02, Filter Tank (Rad); CAS 26-99-01, Radioactively Contaminated Filters; CAS 26-02-01, UST; CAS 26-23-01, Contaminated Liquids Spreader. Based on site history, process knowledge, and previous field efforts, contaminants of potential concern for CAU 127 include radionuclides, metals, total petroleum hydrocarbons, volatile organic compounds, asbestos, and polychlorinated biphenyls. Additionally, beryllium may be present at some locations. The sources of potential releases are varied, but releases of contaminated liquids may have occurred and may have migrated into and impacted soil below and surrounding storage vessels at some of the CASs. Also, at several CASs, asbestos-containing materials may be present on the aboveground structures and may be friable. Exposure pathways are limited to ingestion, inhalation, and dermal contact (adsorption) of soils/sediments or liquids, or inhalation of contaminants by site workers due to disturbance of

  20. Population of Computational Rabbit-Specific Ventricular Action Potential Models for Investigating Sources of Variability in Cellular Repolarisation

    PubMed Central

    Gemmell, Philip; Burrage, Kevin; Rodriguez, Blanca; Quinn, T. Alexander

    2014-01-01

    Variability is observed at all levels of cardiac electrophysiology. Yet, the underlying causes and importance of this variability are generally unknown, and difficult to investigate with current experimental techniques. The aim of the present study was to generate populations of computational ventricular action potential models that reproduce experimentally observed intercellular variability of repolarisation (represented by action potential duration) and to identify its potential causes. A systematic exploration of the effects of simultaneously varying the magnitude of six transmembrane current conductances (transient outward, rapid and slow delayed rectifier K+, inward rectifying K+, L-type Ca2+, and Na+/K+ pump currents) in two rabbit-specific ventricular action potential models (Shannon et al. and Mahajan et al.) at multiple cycle lengths (400, 600, 1,000 ms) was performed. This was accomplished with distributed computing software specialised for multi-dimensional parameter sweeps and grid execution. An initial population of 15,625 parameter sets was generated for both models at each cycle length. Action potential durations of these populations were compared to experimentally derived ranges for rabbit ventricular myocytes. 1,352 parameter sets for the Shannon model and 779 parameter sets for the Mahajan model yielded action potential duration within the experimental range, demonstrating that a wide array of ionic conductance values can be used to simulate a physiological rabbit ventricular action potential. Furthermore, by using clutter-based dimension reordering, a technique that allows visualisation of multi-dimensional spaces in two dimensions, the interaction of current conductances and their relative importance to the ventricular action potential at different cycle lengths were revealed. Overall, this work represents an important step towards a better understanding of the role that variability in current conductances may play in experimentally observed

  1. Observing Children's Learning: Informing Effective Intervention. A Personal Story of Investigative Research in Action.

    ERIC Educational Resources Information Center

    Lockett, Andrew

    This paper outlines the underlying principles that have guided the development of an observational orientation to assessing children's learning. The development of an observation orientation was achieved through a process of a number of action-type research projects within a range of early years settings in the United Kingdom. The paper outlines a…

  2. Using Action Research to Investigate the Use of Digital Information Resources in Further Education

    ERIC Educational Resources Information Center

    Rowley, Jennifer; Ray, Kathryn; Proud, Debbie; Banwell, Linda; Spink, Sian; Thomas, Rhian; Urquhart, Christine

    2004-01-01

    Within the Third Annual Cycle of the Joint Information Systems Committee (JISC) User Behaviour Monitoring and Evaluation Framework, six small-scale action research interventions were undertaken in further education (FE) institutions. The aims of these interventions were two-fold: (i) to develop understanding of the facilitators and barriers to the…

  3. Corrective Action Decision Document/Closure Report for Corrective Action Unit 365: Baneberry Contamination Area, Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews

    2011-09-01

    Corrective Action Unit 365 comprises one corrective action site (CAS), CAS 08-23-02, U-8d Contamination Area. The purpose of this CADD/CR is to provide justification and documentation supporting the recommendation that no further corrective action is needed for CAU 365 based on the implementation of the corrective action of closure in place with a use restriction (UR). Corrective action investigation (CAI) activities were performed from January 18, 2011, through August 2, 2011, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 365: Baneberry Contamination Area. The purpose of the CAI was to fulfill data needs as defined during the data quality objective (DQO) process. The CAU 365 dataset of investigation results was evaluated based on a data quality assessment. This assessment demonstrated the dataset is complete and acceptable for use in supporting the DQO decisions. Investigation results were evaluated against final action levels (FALs) established in this document. A radiological dose FAL of 25 millirem per year was established based on the Remote Work Area exposure scenario (336 hours of annual exposure). Radiological doses exceeding the FAL were found to be present to the southwest of the Baneberry crater. It was also assumed that radionuclide levels present within the crater and fissure exceed the FAL. Corrective actions were undertaken that consisted of establishing a UR and posting warning signs for the crater, fissure, and the area located to the southwest of the crater where soil concentrations exceeded the FAL. These URs were recorded in the FFACO database; the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) Facility Information Management System; and the NNSA/NSO CAU/CAS files. Therefore, NNSA/NSO provides the following recommendations: (1) No further corrective actions beyond what are described in this document are necessary for CAU 365. (2) A Notice of Completion to

  4. Compound ultrarefractory CAI-bearing inclusions from CV3 carbonaceous chondrites

    NASA Astrophysics Data System (ADS)

    Ivanova, Marina A.; Krot, Alexander N.; Nagashima, Kazuhide; MacPherson, Glenn J.

    2012-12-01

    Abstract-Two compound calcium-aluminum-rich inclusions (<span class="hlt">CAIs</span>), 3N from the oxidized CV chondrite Northwest Africa (NWA) 3118 and 33E from the reduced CV chondrite Efremovka, contain ultrarefractory (UR) inclusions. 3N is a forsterite-bearing type B (FoB) <span class="hlt">CAI</span> that encloses UR inclusion 3N-24 composed of Zr,Sc,Y-rich oxides, Y-rich perovskite, and Zr,Sc-rich Al,Ti-diopside. 33E contains a fluffy type A (FTA) <span class="hlt">CAI</span> and UR <span class="hlt">CAI</span> 33E-1, surrounded by Wark-Lovering rim layers of spinel, Al-diopside, and forsterite, and a common forsterite-rich accretionary rim. 33E-1 is composed of Zr,Sc,Y-rich oxides, Y-rich perovskite, Zr,Sc,Y-rich pyroxenes (Al,Ti-diopside, Sc-rich pyroxene), and gehlenite. 3N-24's UR oxides and Zr,Sc-rich Al,Ti-diopsides are 16O-poor (Δ17O approximately -2‰ to -5‰). Spinel in 3N-24 and spinel and Al-diopside in the FoB <span class="hlt">CAI</span> are 16O-rich (Δ17O approximately -23 ± 2‰). 33E-1's UR oxides and Zr,Sc-rich Al,Ti-diopsides are 16O-depleted (Δ17O approximately -2‰ to -5‰) vs. Al,Ti-diopside of the FTA <span class="hlt">CAI</span> and spinel (Δ17O approximately -23 ± 2‰), and Wark-Lovering rim Al,Ti-diopside (Δ17O approximately -7‰ to -19‰). We infer that the inclusions experienced multistage formation in nebular regions with different oxygen-isotope compositions. 3N-24 and 33E-1's precursors formed by evaporation/condensation above 1600 °C. 3N and 33E's precursors formed by condensation and melting (3N only) at significantly lower temperatures. 3N-24 and 3N's precursors aggregated into a compound object and experienced partial melting and thermal annealing. 33E-1 and 33E avoided melting prior to and after aggregation. They acquired Wark-Lovering and common forsterite-rich accretionary rims, probably by condensation, followed by thermal annealing. We suggest 3N-24 and 33E-1 originated in a 16O-rich gaseous reservoir and subsequently experienced isotope exchange in a 16O-poor gaseous reservoir. Mechanism and timing of oxygen-isotope exchange remain</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16332500','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16332500"><span id="translatedtitle">An <span class="hlt">investigation</span> into the antimicrobial mechanisms of <span class="hlt">action</span> of two contact lens biocides using electron microscopy.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Codling, Caroline E; Hann, Anthony C; Maillard, Jean-Yves; Russell, A Denver</p> <p>2005-12-01</p> <p>Polyquaternium-1 (PQ-1) and myristamidopropyl dimethylamine (MAPD) are biocides used commercially in a contact lens disinfecting solutions. Electron microscopy was used to provide further evidence on the mechanism(s) of <span class="hlt">action</span> of these agents against a wide range of ocular pathogens including bacteria, fungi and protozoa. Both PQ-1 and MAPD caused multiple forms of damage to the organisms tested, evidenced by structural alterations, blebbing, leakage and cell destruction. The extent of damage and the selectivity against specific type of microorganisms was consistent with the antimicrobial activity of these agents. Although electron microscopy is a powerful tool, it has its limitations when used to examine the mode of <span class="hlt">action</span> of biocides. Indeed, there was no evidence of gross structural alteration to Acanthamoeba castellani or Aspergillus fumigatus following treatment.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/16332500','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/16332500"><span id="translatedtitle">An <span class="hlt">investigation</span> into the antimicrobial mechanisms of <span class="hlt">action</span> of two contact lens biocides using electron microscopy.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Codling, Caroline E; Hann, Anthony C; Maillard, Jean-Yves; Russell, A Denver</p> <p>2005-12-01</p> <p>Polyquaternium-1 (PQ-1) and myristamidopropyl dimethylamine (MAPD) are biocides used commercially in a contact lens disinfecting solutions. Electron microscopy was used to provide further evidence on the mechanism(s) of <span class="hlt">action</span> of these agents against a wide range of ocular pathogens including bacteria, fungi and protozoa. Both PQ-1 and MAPD caused multiple forms of damage to the organisms tested, evidenced by structural alterations, blebbing, leakage and cell destruction. The extent of damage and the selectivity against specific type of microorganisms was consistent with the antimicrobial activity of these agents. Although electron microscopy is a powerful tool, it has its limitations when used to examine the mode of <span class="hlt">action</span> of biocides. Indeed, there was no evidence of gross structural alteration to Acanthamoeba castellani or Aspergillus fumigatus following treatment. PMID:16332500</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED071443.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED071443.pdf"><span id="translatedtitle">Behavioral Objectives, Sequence, and Aptitude Treatment Interactions in <span class="hlt">CAI</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Tobias, Sigmund; Duchastel, Philippe C.</p> <p></p> <p>The interaction of behavioral objectives, sequence order, and test and state anxiety were <span class="hlt">investigated</span>. The study had four purposes: 1) to examine the effects of objectives on achievement; 2) to <span class="hlt">investigate</span> the effects of sequencing; 3) to study the interaction of availability of objectives and sequence; 4) to study the effects of objectives and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/892463','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/892463"><span id="translatedtitle">Well Installation Report for Corrective <span class="hlt">Action</span> Unit 443, Central Nevada Test Area, Nye County, Nevada, Rev. No.: 0</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Tim Echelard</p> <p>2006-01-01</p> <p>A Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> (<span class="hlt">CAI</span>) was performed in several stages from 1999 to 2003, as set forth in the ''Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan for the Central Nevada Test Area Subsurface Sites, Corrective <span class="hlt">Action</span> Unit 443'' (DOE/NV, 1999). Groundwater modeling was the primary activity of the <span class="hlt">CAI</span>. Three phases of modeling were conducted for the Faultless underground nuclear test. The first phase involved the gathering and interpretation of geologic and hydrogeologic data, and inputting the data into a three-dimensional numerical model to depict groundwater flow. The output from the groundwater flow model was used in a transport model to simulate the migration of a radionuclide release (Pohlmann et al., 2000). The second phase of modeling (known as a Data Decision Analysis [DDA]) occurred after NDEP reviewed the first model. This phase was designed to respond to concerns regarding model uncertainty (Pohll and Mihevc, 2000). The third phase of modeling updated the original flow and transport model to incorporate the uncertainty identified in the DDA, and focused the model domain on the region of interest to the transport predictions. This third phase culminated in the calculation of contaminant boundaries for the site (Pohll et al., 2003). Corrective <span class="hlt">action</span> alternatives were evaluated and an alternative was submitted in the ''Corrective <span class="hlt">Action</span> Decision Document/Corrective <span class="hlt">Action</span> Plan for Corrective <span class="hlt">Action</span> Unit 443: Central Nevada Test Area-Subsurface'' (NNSA/NSO, 2004). Based on the results of this evaluation, the preferred alternative for CAU 443 is Proof-of-Concept and Monitoring with Institutional Controls. This alternative was judged to meet all requirements for the technical components evaluated and will control inadvertent exposure to contaminated groundwater at CAU 443.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/909125','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/909125"><span id="translatedtitle">Corrective <span class="hlt">Action</span> Decision Document for Corrective <span class="hlt">Action</span> Unit 166: Storage Yards and Contaminated Materials, Nevada Test Site, Nevada with Errata Sheet</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Grant Evenson</p> <p>2007-03-01</p> <p>This Corrective <span class="hlt">Action</span> Decision Document (CADD) has been prepared for Corrective <span class="hlt">Action</span> Unit (CAU) 166, Storage Yards and Contaminated Materials, in accordance with the Federal Facility Agreement and Consent Order (1996). The corrective <span class="hlt">action</span> sites (CASs) are located in Areas 2, 3, 5, and 18 of the Nevada Test Site, Nevada. Corrective <span class="hlt">Action</span> Unit 166 is comprised of the following CASs: • 02-42-01, Cond. Release Storage Yd - North • 02-42-02, Cond. Release Storage Yd - South • 02-99-10, D-38 Storage Area • 03-42-01, Conditional Release Storage Yard • 05-19-02, Contaminated Soil and Drum • 18-01-01, Aboveground Storage Tank • 18-99-03, Wax Piles/Oil Stain The purpose of this CADD is to identify and provide the rationale for the recommendation of a corrective <span class="hlt">action</span> alternative (CAA) for the seven CASs within CAU 166. Corrective <span class="hlt">action</span> <span class="hlt">investigation</span> (<span class="hlt">CAI</span>) activities were performed from July 31, 2006, through February 28, 2007, as set forth in the CAU 166 Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan (NNSA/NSO, 2006).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/22051268','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/22051268"><span id="translatedtitle"><span class="hlt">Investigation</span> of molecular mechanisms of <span class="hlt">action</span> of chelating drugs on protein-lipid model membranes by X-ray fluorescence</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Novikova, N. N.; Zheludeva, S. I.; Koval'chuk, M. V.; Stepina, N. D.; Erko, A. I.; Yur'eva, E. A.</p> <p>2009-12-15</p> <p>Protein-lipid films based on the enzyme alkaline phosphatase were subjected to the <span class="hlt">action</span> of chelating drugs, which are used for accelerating the removal of heavy metals from the human body, and the elemental composition of the resulting films was <span class="hlt">investigated</span>. Total-reflection X-ray fluorescence measurements were performed at the Berlin Electron Storage Ring Company for Synchrotron Radiation (BESSY) in Germany. A comparative estimation of the protective effect of four drugs (EDTA, succimer, xydiphone, and mediphon) on membrane-bound enzymes damaged by lead ions was made. The changes in the elemental composition of the protein-lipid films caused by high doses of chelating drugs were <span class="hlt">investigated</span>. It was shown that state-of-the-art X-ray techniques can, in principle, be used to develop new methods for the in vitro evaluation of the efficiency of drugs, providing differential data on their <span class="hlt">actions</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19750022313','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19750022313"><span id="translatedtitle">Alternative communication network designs for an operational Plato 4 <span class="hlt">CAI</span> system</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Mobley, R. E., Jr.; Eastwood, L. F., Jr.</p> <p>1975-01-01</p> <p>The cost of alternative communications networks for the dissemination of PLATO IV computer-aided instruction (<span class="hlt">CAI</span>) was studied. Four communication techniques are compared: leased telephone lines, satellite communication, UHF TV, and low-power microwave radio. For each network design, costs per student contact hour are computed. These costs are derived as functions of student population density, a parameter which can be calculated from census data for one potential market for <span class="hlt">CAI</span>, the public primary and secondary schools. Calculating costs in this way allows one to determine which of the four communications alternatives can serve this market least expensively for any given area in the U.S. The analysis indicates that radio distribution techniques are cost optimum over a wide range of conditions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/1016134','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/1016134"><span id="translatedtitle">Corrective <span class="hlt">Action</span> Decision Document/Closure Report for Corrective <span class="hlt">Action</span> Unit 372: Area 20 Cabriolet/Palanquin Unit Craters, Nevada National Security Site, Nevada, Revision 0</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Matthews, Patrick and Sloop, Christy</p> <p>2011-04-01</p> <p>This Corrective <span class="hlt">Action</span> Decision Document (CADD)/Closure Report (CR) has been prepared for Corrective <span class="hlt">Action</span> Unit (CAU) 372, Area 20 Cabriolet/Palanquin Unit Craters, located within Areas 18 and 20 at the Nevada National Security Site, Nevada, in accordance with the Federal Facility Agreement and Consent Order (FFACO). Corrective <span class="hlt">Action</span> Unit 372 comprises four corrective <span class="hlt">action</span> sites (CASs): • 18-45-02, Little Feller I Surface Crater • 18-45-03, Little Feller II Surface Crater • 20-23-01, U-20k Contamination Area • 20-45-01, U-20L Crater (Cabriolet) The purpose of this CADD/CR is to provide justification and documentation supporting the recommendation that no further corrective <span class="hlt">action</span> is needed for CAU 372 based on the implementation of the corrective <span class="hlt">action</span> of closure in place with administrative controls at all CASs. Corrective <span class="hlt">action</span> <span class="hlt">investigation</span> (<span class="hlt">CAI</span>) activities were performed from November 9, 2009, through December 10, 2010, as set forth in the Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan for Corrective <span class="hlt">Action</span> Unit 372: Area 20 Cabriolet/Palanquin Unit Craters. The approach for the <span class="hlt">CAI</span> was divided into two facets: <span class="hlt">investigation</span> of the primary release of radionuclides and <span class="hlt">investigation</span> of other releases (migration in washes and chemical releases). The purpose of the <span class="hlt">CAI</span> was to fulfill data needs as defined during the data quality objective (DQO) process. The CAU 372 dataset of <span class="hlt">investigation</span> results was evaluated based on a data quality assessment. This assessment demonstrated the dataset is acceptable for use in fulfilling the DQO data needs. <span class="hlt">Investigation</span> results were evaluated against final <span class="hlt">action</span> levels (FALs) established in this document. A radiological dose FAL was established of 25 millirem per year based on the Remote Work Area exposure scenario (336 hours of annual exposure). Radiological doses exceeding the FAL were found to be present at all four CASs. It is assumed that radionuclide levels present within the Little Feller I and Cabriolet high</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2010OptSp.109..225G&link_type=ABSTRACT','NASAADS'); return false;" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2010OptSp.109..225G&link_type=ABSTRACT"><span id="translatedtitle">Optical clearing of skin under <span class="hlt">action</span> of glycerol: Ex vivo and in vivo <span class="hlt">investigations</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Genina, E. A.; Bashkatov, A. N.; Sinichkin, Yu. P.; Tuchin, V. V.</p> <p>2010-08-01</p> <p>The behavior of optical parameters of the skin of a laboratory rat under the <span class="hlt">action</span> of an aqueous solution of glycerol is studied ex vivo and in vivo. It is found that the collimated transmission coefficient of ex vivo skin samples increases by a factor of 20-40-fold depending on the wavelength in the studied spectral range, and the diffuse reflection coefficient of skin in vivo decreases on the average by 16%. The results presented can be useful for many methods of laser therapy and optical diagnostics of skin diseases and localization of subcutaneous neoplasms.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/22694314','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/22694314"><span id="translatedtitle">Emotional reactions to success and failure of collective <span class="hlt">action</span> as predictors of future <span class="hlt">action</span> intentions: a longitudinal <span class="hlt">investigation</span> in the context of student protests in Germany.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tausch, Nicole; Becker, Julia C</p> <p>2013-09-01</p> <p>This research examined how emotional responses to success and failure of collective <span class="hlt">action</span> relate to willingness to engage in collective <span class="hlt">action</span> in the future. It was hypothesized that both pride (in relation to a success) and anger (in response to failure) would motivate future collective <span class="hlt">action</span>. Findings are reported from a two-wave longitudinal study (N= 98) in the context of student protests against tuition fees in Germany, which was conducted before and after collective <span class="hlt">action</span> had resulted in both a success and a failure. While anger positively predicted <span class="hlt">action</span> intentions, over and above baseline <span class="hlt">action</span> intentions, pride exerted a significant indirect effect on <span class="hlt">action</span> intentions via increased efficacy perceptions, over and above baseline efficacy and <span class="hlt">action</span> intentions. Politicized identification positively predicted the intensity of both pride and anger and baseline group efficacy positively predicted the intensity of anger. The theoretical and practical implications of these findings are discussed. PMID:22694314</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2317824','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2317824"><span id="translatedtitle">Mechanistic <span class="hlt">investigations</span> on the antioxidant <span class="hlt">action</span> of a neuroprotective estrogen derivative</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Prokai-Tatrai, Katalin; Perjesi, Pal; Rivera-Portalatin, Nilka M.; Simpkins, James W.; Prokai, Laszlo</p> <p>2008-01-01</p> <p>Antioxidant <span class="hlt">action</span> is an important component of the complex neuroprotective <span class="hlt">action</span> of estrogens. Combining theoretical prediction and subsequent experimental confirmation by chemical and in vitro paradigms, this study focused on the mechanistic aspects of hydroxyl-radical scavenging by 17β-butoxy-1,3,5(10)-estratrien-3-ol, a synthetic derivative of 17β-estradiol with increased potency to inhibit lipid peroxidation and reduced affinity to estrogen-receptors compared to the endogenous hormone. In the process that acts as a “chemical shield,” the phenolic A-ring turns into 10β-hydroxy-17β-butoxy-1,3,5(10)-estratrien-3-one, a non-aromatic para-quinol, upon capturing hydroxyl-radicals, which results in the complete loss of estrogen-receptor affinity and antioxidant activity. However, the parent compound is apparently recovered in brain tissue from this para-quinol via enzyme-catalyzed NAD(P)H-dependent reductive aromatization without causing oxidative stress. Taken together, our report argues for a previously unrecognized antioxidant cycle for synthetic estrogen-derived compounds. PMID:18068745</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2014ApSS..317..657M&link_type=ABSTRACT','NASAADS'); return false;" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2014ApSS..317..657M&link_type=ABSTRACT"><span id="translatedtitle">An <span class="hlt">investigation</span> on the inhibitory <span class="hlt">action</span> of benzazole derivatives as a consequence of sulfur atom induction</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Moradi, Z.; Attar, M. M.</p> <p>2014-10-01</p> <p>The inhibitory <span class="hlt">action</span> of three benzazole based molecules namely 2-methyl benzimidazole (2-MBI), 2-methyl benzothiazole (2-MBT) and 2-mercapto benzthiazole (2-SHBT) in 1 M HCl solution was studied by gravimetric analysis and electrochemical impedance spectroscopy (EIS). Results showed that the inhibitor adsorption on the iron surface was according to Langmuir adsorption isotherm for 2-MBI and 2-MBT and Flory Huggins Isotherm for 2-SHBT. Surface roughness obtained by Atomic Forced Microscopy (AFM) revealed that a good inhibitor decreases the surface roughness significantly which can be related to the formation of more integrated molecular film of inhibitor on steel surface. Based on contact angle (CA) measurements as the efficiency of the inhibitor molecules improve the hydrophobicity increases. These three molecules were chosen to see the effect of introducing sulfur atom into the structure the main effect of which would be on electronic parameters. To better understand this effect, the quantum chemical descriptors including: EHOMO, ELUMO, energy gap (ΔE), dipole moment (μ), hardness (η), softness (σ), electronegativity index (χ), fraction of electrons transferred (ΔN), that are most relevant to the potential <span class="hlt">action</span> of a molecule as corrosion inhibitor, have been calculated in water and vacuum. Electronic parameters of these three inhibitors have been studied using DFT/B3LYP, and HF methods with 6-31G (d,p) basis set.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3236788','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3236788"><span id="translatedtitle"><span class="hlt">Investigating</span> the Antimalarial <span class="hlt">Action</span> of 1,2,4-Trioxolanes with Fluorescent Chemical Probes</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Hartwig, Carmony L.; Lauterwasser, Erica M.W.; Mahajan, Sumit S.; Hoke, Jonathan M.; Cooper, Roland A.; Renslo, Adam R.</p> <p>2011-01-01</p> <p>The 1,2,4-trioxolanes are a new class of synthetic peroxidic antimalarials currently in human clinical trials. The well known reactivity of the 1,2,4-trioxolane ring towards inorganic ferrous iron and ferrous iron heme is proposed to play a role in the antimalarial <span class="hlt">action</span> of this class of compounds. We have designed structurally relevant fluorescent chemical probes to study the sub-cellular localization of 1,2,4-trioxolanes in cultured Plasmodium falciparum parasites. Microscopy experiments revealed that a probe fluorescently labeled on the adamantane ring accumulated specifically in digestive vacuole-associated neutral lipid bodies within the parasite while an isosteric, but non-peroxidic congener did not. Probes fluorescently labeled on the cyclohexane ring showed no distinct localization pattern. In their sub-cellular localization and peroxidative effects, 1,2,4-trioxolane probes behave much like artemisinin-based probes studied previously. Our results are consistent with a role for adamantane-derived carbon-centered radicals in the antimalarial <span class="hlt">action</span> of 1,2,4-trioxolanes, as hypothesized previously on the basis of chemical reactivity studies. PMID:22023506</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/7646472','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/7646472"><span id="translatedtitle">Kinetic <span class="hlt">investigation</span> of the <span class="hlt">action</span> of hyaluronidase on hyaluronan using the Morgan-Elson and neocuproine assays.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Vercruysse, K P; Lauwers, A R; Demeester, J M</p> <p>1995-08-15</p> <p>In this paper we describe kinetic <span class="hlt">investigations</span> of the <span class="hlt">action</span> of testicular hyaluronidase on hyaluronan. We have compared the use of two spectrophotometric assays, the first based on the Morgan-Elson reaction and the second on the neocuproine reaction. With the neocuproine reaction Km was found to be 0.46 mg/ml and Vmax to be 126 nmol l-1 s-1. Because of a low sensitivity and the production of interfering precipitates, the Morgan-Elson assay cannot be used for kinetic <span class="hlt">investigation</span> of the enzyme. Furthermore this assay is prone to interference from compounds such as disodium cromoglycate, (+)-catechine, penicillamine, CaCl2 and acetate buffer.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/817109','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/817109"><span id="translatedtitle">Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan for Corrective <span class="hlt">Action</span> Unit 322: Areas 1 and 3 Release Sites and Injection Wells, Nevada Test Site, Nevada: Revision 0, Including Record of Technical Change No. 1</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office</p> <p>2003-07-16</p> <p>This Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan contains the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office's approach to collect the data necessary to evaluate corrective <span class="hlt">action</span> alternatives (CAAs) appropriate for the closure of Corrective <span class="hlt">Action</span> Unit (CAU) 322, Areas 1 and 3 Release Sites and Injection Wells, Nevada Test Site, Nevada, under the Federal Facility Agreement and Consent Order. Corrective <span class="hlt">Action</span> Unit 322 consists of three Corrective <span class="hlt">Action</span> Sites (CASs): 01-25-01, AST Release (Area 1); 03-25-03, Mud Plant AST Diesel Release (Area 3); 03-20-05, Injection Wells (Area 3). Corrective <span class="hlt">Action</span> Unit 322 is being <span class="hlt">investigated</span> because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective <span class="hlt">action</span> alternatives. The <span class="hlt">investigation</span> of three CASs in CAU 322 will determine if hazardous and/or radioactive constituents are present at concentrations and locations that could potentially pose a threat to human health and the environment. The results of this field <span class="hlt">investigation</span> will support a defensible evaluation of corrective <span class="hlt">action</span> alternatives in the corrective <span class="hlt">action</span> decision document.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3629304','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3629304"><span id="translatedtitle">An <span class="hlt">investigation</span> of semantic similarity judgments about <span class="hlt">action</span> and non-<span class="hlt">action</span> verbs in Parkinson's disease: implications for the Embodied Cognition Framework</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Kemmerer, David; Miller, Luke; MacPherson, Megan K.; Huber, Jessica; Tranel, Daniel</p> <p>2013-01-01</p> <p>The Embodied Cognition Framework maintains that understanding <span class="hlt">actions</span> requires motor simulations subserved in part by premotor and primary motor regions. This hypothesis predicts that disturbances to these regions should impair comprehension of <span class="hlt">action</span> verbs but not non-<span class="hlt">action</span> verbs. We evaluated the performances of 10 patients with Parkinson's disease (PD) and 10 normal comparison (NC) participants on a semantic similarity judgment task (SSJT) that included four classes of <span class="hlt">action</span> verbs and two classes of non-<span class="hlt">action</span> verbs. The patients were tested both ON and OFF medication. The most salient results involved the accuracies and reaction times (RTs) for the <span class="hlt">action</span> verbs taken as a whole and the non-<span class="hlt">action</span> verbs taken as a whole. With respect to accuracies, the patients did not perform significantly worse than the NC participants for either the <span class="hlt">action</span> verbs or the non-<span class="hlt">action</span> verbs, regardless of whether they were ON or OFF their medication. And with respect to RTs, although the patients' responses were significantly slower than those of the NC participants for the <span class="hlt">action</span> verbs, comparable processing delays were also observed for the non-<span class="hlt">action</span> verbs; moreover, there was again no notable influence of medication. The major dissociation was therefore not between <span class="hlt">action</span> and non-<span class="hlt">action</span> verbs, but rather between accuracies (relatively intact) and RTs (relatively delayed). Overall, the data suggest that semantic similarity judgments for both <span class="hlt">action</span> and non-<span class="hlt">action</span> verbs are correct but slow in individuals with PD. These results provide new insights about language processing in PD, and they raise important questions about the explanatory scope of the Embodied Cognition Framework. PMID:23616759</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li class="active"><span>16</span></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_16 --> <div id="page_17" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li class="active"><span>17</span></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="321"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25186361','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25186361"><span id="translatedtitle">Crystal structures of hydrates of simple inorganic salts. II. Water-rich calcium bromide and iodide hydrates: CaBr2 · 9H2O, <span class="hlt">CaI</span>2 · 8H2O, <span class="hlt">CaI</span>2 · 7H2O and <span class="hlt">CaI</span>2 · 6.5H2O.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hennings, Erik; Schmidt, Horst; Voigt, Wolfgang</p> <p>2014-09-01</p> <p>Single crystals of calcium bromide enneahydrate, CaBr(2) · 9H2O, calcium iodide octahydrate, <span class="hlt">CaI</span>(2) · 8H2O, calcium iodide heptahydrate, <span class="hlt">CaI</span>(2) · 7H2O, and calcium iodide 6.5-hydrate, <span class="hlt">CaI</span>(2) · 6.5H2O, were grown from their aqueous solutions at and below room temperature according to the solid-liquid phase diagram. The crystal structure of <span class="hlt">CaI</span>(2) · 6.5H2O was redetermined. All four structures are built up from distorted Ca(H2O)8 antiprisms. The antiprisms of the iodide hydrate structures are connected either via trigonal-plane-sharing or edge-sharing, forming dimeric units. The antiprisms in calcium bromide enneahydrate are monomeric. PMID:25186361</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/1027857','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/1027857"><span id="translatedtitle">Corrective <span class="hlt">Action</span> Decision Document/Closure Report for Corrective <span class="hlt">Action</span> Unit 375: Area 30 Buggy Unit Craters, Nevada National Security Site, Nevada, Revision 0</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Patrick Matthews</p> <p>2011-08-01</p> <p>Corrective <span class="hlt">Action</span> Unit 375 comprises three corrective <span class="hlt">action</span> sites (CASs): (1) 25-23-22, Contaminated Soils Site; (2) 25-34-06, Test Cell A Bunker; and (3) 30-45-01, U-30a, b, c, d, e Craters. The purpose of this CADD/CR is to provide justification and documentation supporting the recommendation that no further corrective <span class="hlt">action</span> is needed for CAU 375 based on the implementation of corrective <span class="hlt">action</span> of closure in place with administrative controls at CAS 25-23-22, no further <span class="hlt">action</span> at CAS 25-34-06, and closure in place with administrative controls and removal of potential source material (PSM) at CAS 30-45-01. Corrective <span class="hlt">action</span> <span class="hlt">investigation</span> (<span class="hlt">CAI</span>) activities were performed from July 28, 2010, through April 4, 2011, as set forth in the Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan for Corrective <span class="hlt">Action</span> Unit 375: Area 30 Buggy Unit Craters. The approach for the <span class="hlt">CAI</span> was divided into two facets: <span class="hlt">investigation</span> of the primary release of radionuclides, and <span class="hlt">investigation</span> of other releases (migration in washes and chemical releases). The purpose of the <span class="hlt">CAI</span> was to fulfill data needs as defined during the data quality objective (DQO) process. The CAU 375 dataset of <span class="hlt">investigation</span> results was evaluated based on the data quality assessment. This assessment demonstrated the dataset is acceptable for use in fulfilling the DQO data needs. <span class="hlt">Investigation</span> results were evaluated against final <span class="hlt">action</span> levels (FALs) established in this document. A radiological dose FAL of 25 millirem per year was established based on the Remote Work Area exposure scenario (336 hours of annual exposure). Radiological doses exceeding the FAL were assumed to be present within the default contamination boundaries at CASs 25-23-22 and 30-45-01. No contaminants were identified at CAS 25-34-06, and no corrective <span class="hlt">action</span> is necessary. Potential source material in the form of lead plate, lead-acid batteries, and oil within an abandoned transformer were identified at CAS 30-45-01, and corrective <span class="hlt">actions</span> were undertaken that</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016E%26PSL.440...62A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016E%26PSL.440...62A"><span id="translatedtitle">Oxygen isotopes in the early protoplanetary disk inferred from pyroxene in a classical type B <span class="hlt">CAI</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Aléon, Jérôme</p> <p>2016-04-01</p> <p>A major unanswered question in solar system formation is the origin of the oxygen isotopic dichotomy between the Sun and the planets. Individual Calcium-Aluminum-rich inclusions (<span class="hlt">CAIs</span>) from CV chondrites exhibit almost the full isotopic range, but how their composition evolved is still unclear, which prevents robust astrochemical conclusions. A key issue is notably the yet unsolved origin of the 16O-rich isotopic composition of pyroxene in type B <span class="hlt">CAIs</span>. Here, I report an in-situ oxygen isotope study of the archetypal type B <span class="hlt">CAI</span> USNM-3529-Z from Allende with emphasis on the isotopic composition of pyroxene and its isotopic and petrographic relationships with other major minerals. The O isotopic composition of pyroxene is correlated with indicators of magmatic growth, indicating that the pyroxene evolved from a 16O-poor composition and became progressively enriched in 16O during its crystallization, contrary to the long held assumption that pyroxene was initially 16O-rich. This variation is well explained by isotopic exchange between a 16O-poor partial melt having the isotopic composition of melilite and a 16O-rich gas having the isotopic composition of spinel, during pyroxene crystallization. The isotopic evolution of 3529-Z is consistent with formation in an initially 16O-rich environment where spinel and gehlenitic melilite crystallized, followed by a 16O-depletion associated with melilite partial melting and recrystallization and finally a return to the initial 16O-rich environment before pyroxene crystallization. This strongly suggests that the environment of <span class="hlt">CAI</span> formation was globally 16O-rich, with local 16O-depletions systematically associated with high temperature events. The Al/Mg isotopic systematics of 3529-Z further indicates that this suite of isotopic changes occurred in the first 150 000 yr of the solar system, during the main <span class="hlt">CAI</span> formation period. A new astrophysical setting is proposed, where the 16O-depletion occurs in an optically thin surface</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20090020501','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20090020501"><span id="translatedtitle">Rare Earth Element Measurements of Melilite and Fassaite in Allende <span class="hlt">Cai</span> by Nanosims</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Ito, M.; Messenger, Scott</p> <p>2009-01-01</p> <p>The rare earth elements (REEs) are concentrated in <span class="hlt">CAIs</span> by approx. 20 times the chondritic average [e.g., 1]. The REEs in <span class="hlt">CAIs</span> are important to understand processes of <span class="hlt">CAI</span> formation including the role of volatilization, condensation, and fractional crystallization [1,2]. REE measurements are a well established application of ion microprobes [e.g., 3]. However the spatial resolution of REE measurements by ion microprobe (approx.20 m) is not adequate to resolve heterogeneous distributions of REEs among/within minerals. We have developed methods for measuring REE with the NanoSIMS 50L at smaller spatial scales. Here we present our initial measurements of REEs in melilite and fassaite in an Allende Type-A <span class="hlt">CAI</span> with the JSC NanoSIMS 50L. We found that the key parameters for accurate REE abundance measurements differ between the NanoSIMS and conventional SIMS, in particular the oxide-to-element ratios, the relative sensitivity factors, the energy distributions, and requisite energy offset. Our REE abundance measurements of the 100 ppm REE diopside glass standards yielded good reproducibility and accuracy, 0.5-2.5 % and 5-25 %, respectively. We determined abundances and spatial distributions of REEs in core and rim within single crystals of fassaite, and adjacent melilite with 5-10 m spatial resolution. The REE abundances in fassaite core and rim are 20-100 times CI abundance but show a large negative Eu anomaly, exhibiting a well-defined Group III pattern. This is consistent with previous work [4]. On the other hand, adjacent melilite shows modified Group II pattern with no strong depletions of Eu and Yb, and no Tm positive anomaly. REE abundances (2-10 x CI) were lower than that of fassaite. These patterns suggest that fassaite crystallized first followed by a crystallization of melilite from the residual melt. In future work, we will carry out a correlated study of O and Mg isotopes and REEs of the <span class="hlt">CAI</span> in order to better understand the nature and timescales of its</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/8528','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/8528"><span id="translatedtitle">Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan for Corrective <span class="hlt">Action</span> Unit 263: Area 25 Building 4839 Leachfields, Nevada Test Site, Revision 0, DOE/NV--535 UPDATED WITH RECORD OF TECHNICAL CHANGE No.1</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>US DOE Nevada Operations Office</p> <p>1999-04-12</p> <p>The Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan for Corrective <span class="hlt">Action</span> Unit 263, the Area 25 Building 4839 Leachfield, has been developed in accordance with the Federal Facility Agreement and Consent Order that was agreed to by the US Department of Energy, Nevada Operations Office; the Nevada Division of Environmental Protection; and the US Department of Defense. Corrective <span class="hlt">Action</span> Unit 263 is comprised of the Corrective <span class="hlt">Action</span> Site 25-05-04 sanitary leachfield and associated collection system. This Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan is used in combination with the Work Plan for Leachfield Corrective <span class="hlt">Action</span> Units: Nevada Test Site and Tonopah Test Range, Nevada (DOE/NV, 1998d). The Leachfield Work Plan was developed to streamline <span class="hlt">investigations</span> at Leachfield Corrective <span class="hlt">Action</span> Units by incorporating management, technical, quality assurance, health and safety, public involvement, field sampling, and waste management information common to a set of Corrective <span class="hlt">Action</span> Units with similar site histories and characteristics into a single document that can be referenced. This Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan provides <span class="hlt">investigative</span> details specific to Corrective <span class="hlt">Action</span> Unit 263. Corrective <span class="hlt">Action</span> Unit 263 is located southwest of Building 4839, in the Central Propellant Storage Area. Operations in Building 4839 from 1968 to 1996 resulted in effluent releases to the leachfield and associated collection system. In general, effluent released to the leachfield consisted of sanitary wastewater from a toilet, urinal, lavatory, and drinking fountain located within Building 4839. The subsurface soils in the vicinity of the collection system and leachfield may have been impacted by effluent containing contaminants of potential concern generated by support activities associated with the Building 4839 operations.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014PhDT.......128J','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014PhDT.......128J"><span id="translatedtitle">Institutional Diversity in Collective <span class="hlt">Action</span>: <span class="hlt">Investigating</span> Successful Village Level Maintenance of Hand Pumps in Malawi</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Joubert, Brian Anthony</p> <p></p> <p>Providing clean water to rural communities in sub-Saharan Africa remains a challenge. Unsanitary and distant water sources cause a host of health and humanitarian problems. A common means of remedying this situation has been the donation of improved water sources, fitted with low-cost hand pumps. Due donor capacity and/ or policy most hand pumps are donated under the guise of Village Level Operation and Maintenance (VLOM). This premises the notion that recipient communities will take ownership of the new pump and as such will ensure its maintenance. To assist with this many donors carry out programs of technical repair training and the structuring of in-village leadership and management groups. The reality is that a high proportion of these pumps break down after donation and cease to work thereafter. Measures to redress technical elements of these failures through increased training or adequate distribution of spares has seen some success but failure rates remains high. This has led to a call for more attention to demand side issues, focusing on the communal aspects that may influence a village to act collectively in the maintenance of its hand pump. This thesis researched five Malawian villages where the community had maintained their hand pumps for a period of 10 or more years. These hand pumps were treated as shared resources and the literature on common-pool resources and social institutions was used as a theoretical framework. Applying these theories proved to be appropriate for analyzing the norms, conventions and forms of cooperative conduct. This allowed the research to gain insights into institutional diversity and the relationship between 'formal institutions', most often exogenous in nature, and informal' or customary collective <span class="hlt">action</span> institutions embedded within the communities. Findings showed the emergence of three predominant themes within these successful case studies: 1) the role of leadership at varying levels and how it is embodied</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23023027','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23023027"><span id="translatedtitle">Addressing bioterrorism concerns: options for <span class="hlt">investigating</span> the mechanism of <span class="hlt">action</span> of Staphylococcus aureus enterotoxin B.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lindsay, C D; Griffiths, G D</p> <p>2013-06-01</p> <p>Staphylococcal enterotoxin B (SEB) is of concern to military and civilian populations as a bioterrorism threat agent. It is a highly potent toxin produced by Staphylococcus aureus and is stable in storage and under aerosolisation; it is able to produce prolonged highly incapacitating illness at very low-inhaled doses and death at elevated doses. Concerns regarding SEB are compounded by the lack of effective medical countermeasures for mass treatment of affected populations. This article considers the mechanism of <span class="hlt">action</span> of SEB, the availability of appropriate experimental models for evaluating the efficacy of candidate medical countermeasures with particular reference to the need to realistically model SEB responses in man and the availability of candidate countermeasures (with an emphasis on commercial off-the-shelf options). The proposed in vitro approaches would be in keeping with Dstl’s commitment to reduction, refinement and replacement of animal models in biomedical research, particularly in relation to identifying valid alternatives to the use of nonhuman primates in experimental studies.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27240203','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27240203"><span id="translatedtitle">Landowner's perception of flood risk and preventive <span class="hlt">actions</span> in estuarine environment: An empirical <span class="hlt">investigation</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rambonilaza, Tina; Joalland, Olivier; Brahic, Elodie</p> <p>2016-09-15</p> <p>Within Europe, flood and coastal risk management is undergoing a major paradigm shift as it moves from an approach dominated by investment in flood defence and control infrastructure to another one in which non-structural measures are favoured. One research challenge consists in developing a better understanding of local population risk perception and its effects on prevention and preparedness <span class="hlt">actions</span> in order to improve social acceptability of adaptive flood risk management. Landowners' involvement in wetland management offer benefits beyond the line of their property. Accordingly, the purpose of this study is to achieve an empirical understanding of risk perception and self-protective behaviour among the landowners of the riparian marshes in the Gironde Estuary, in France. Application of the psychometric approach reveals that flood risk perception among landowners can be characterised by three synthetic variables that indicate on the degree of exposure, the sense of control and knowledge of the risk. Examining the relationships between these perceived risk dimensions and landowners' participation in water structures management provides three profiles of self-protective behaviour distinguishing "vulnerable", "autonomous", and "passive" individuals. Finally, implications of our findings for the management of flood risk in estuarine environment which is often drained areas are discussed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4795590','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4795590"><span id="translatedtitle">Drug-set enrichment analysis: a novel tool to <span class="hlt">investigate</span> drug mode of <span class="hlt">action</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Napolitano, Francesco; Sirci, Francesco; Carrella, Diego; di Bernardo, Diego</p> <p>2016-01-01</p> <p>Motivation: Automated screening approaches are able to rapidly identify a set of small molecules inducing a desired phenotype from large small-molecule libraries. However, the resulting set of candidate molecules is usually very diverse pharmacologically, thus little insight on the shared mechanism of <span class="hlt">action</span> (MoA) underlying their efficacy can be gained. Results: We introduce a computational method (Drug-Set Enrichment Analysis—DSEA) based on drug-induced gene expression profiles, which is able to identify the molecular pathways that are targeted by most of the drugs in the set. By diluting drug-specific effects unrelated to the phenotype of interest, DSEA is able to highlight phenotype-specific pathways, thus helping to formulate hypotheses on the MoA shared by the drugs in the set. We validated the method by analysing five different drug-sets related to well-known pharmacological classes. We then applied DSEA to identify the MoA shared by drugs known to be partially effective in rescuing mutant cystic fibrosis transmembrane conductance regulator (CFTR) gene function in Cystic Fibrosis. Availability and implementation: The method is implemented as an online web tool publicly available at http://dsea.tigem.it. Contact: dibernardo@tigem.it Supplementary information: Supplementary data are available at Bioinformatics online. PMID:26415724</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27240203','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27240203"><span id="translatedtitle">Landowner's perception of flood risk and preventive <span class="hlt">actions</span> in estuarine environment: An empirical <span class="hlt">investigation</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rambonilaza, Tina; Joalland, Olivier; Brahic, Elodie</p> <p>2016-09-15</p> <p>Within Europe, flood and coastal risk management is undergoing a major paradigm shift as it moves from an approach dominated by investment in flood defence and control infrastructure to another one in which non-structural measures are favoured. One research challenge consists in developing a better understanding of local population risk perception and its effects on prevention and preparedness <span class="hlt">actions</span> in order to improve social acceptability of adaptive flood risk management. Landowners' involvement in wetland management offer benefits beyond the line of their property. Accordingly, the purpose of this study is to achieve an empirical understanding of risk perception and self-protective behaviour among the landowners of the riparian marshes in the Gironde Estuary, in France. Application of the psychometric approach reveals that flood risk perception among landowners can be characterised by three synthetic variables that indicate on the degree of exposure, the sense of control and knowledge of the risk. Examining the relationships between these perceived risk dimensions and landowners' participation in water structures management provides three profiles of self-protective behaviour distinguishing "vulnerable", "autonomous", and "passive" individuals. Finally, implications of our findings for the management of flood risk in estuarine environment which is often drained areas are discussed. PMID:27240203</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20202334','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20202334"><span id="translatedtitle">Zoonoses <span class="hlt">action</span> plan Salmonella monitoring programme: an <span class="hlt">investigation</span> of the sampling protocol.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Snary, E L; Munday, D K; Arnold, M E; Cook, A J C</p> <p>2010-03-01</p> <p>The Zoonoses <span class="hlt">Action</span> Plan (ZAP) Salmonella Programme was established by the British Pig Executive to monitor Salmonella prevalence in quality-assured British pigs at slaughter by testing a sample of pigs with a meat juice enzyme-linked immunosorbent assay for antibodies against group B and C(1) Salmonella. Farms were assigned a ZAP level (1 to 3) depending on the monitored prevalence, and ZAP 2 or 3 farms were required to act to reduce the prevalence. The ultimate goal was to reduce the risk of human salmonellosis attributable to British pork. A mathematical model has been developed to describe the ZAP sampling protocol. Results show that the probability of assigning a farm the correct ZAP level was high, except for farms that had a seroprevalence close to the cutoff points between different ZAP levels. Sensitivity analyses identified that the probability of assigning a farm to the correct ZAP level was dependent on the sensitivity and specificity of the test, the number of batches taken to slaughter each quarter, and the number of samples taken per batch. The variability of the predicted seroprevalence was reduced as the number of batches or samples increased and, away from the cutoff points, the probability of being assigned the correct ZAP level increased as the number of batches or samples increased. In summary, the model described here provided invaluable insight into the ZAP sampling protocol. Further work is required to understand the impact of the program for Salmonella infection in British pig farms and therefore on human health.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/877408','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/877408"><span id="translatedtitle">Corrective <span class="hlt">Action</span> Decision Document/Closure Report for Corrective <span class="hlt">Action</span> Unit 554: Area 23 Release Site Nevada Test Site, Nevada, Rev. No.: 0 with Errata Sheet</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Evenson, Grant</p> <p>2005-12-01</p> <p>This Corrective <span class="hlt">Action</span> Decision Document/Closure Report has been prepared for Corrective <span class="hlt">Action</span> Unit 554, Area 23 Release Site, located in Mercury at the Nevada Test Site, Nevada, in accordance with the ''Federal Facility Agreement and Consent Order'' (1996). Corrective <span class="hlt">Action</span> Unit (CAU) 554 is comprised of one corrective <span class="hlt">action</span> site (CAS): CAS 23-02-08, USTs 23-115-1, 2, 3/Spill 530-90-002. The purpose of this Corrective <span class="hlt">Action</span> Decision Document/Closure Report is to provide justification and documentation supporting the recommendation for closure of CAU 554 with no further corrective <span class="hlt">action</span>. To achieve this, corrective <span class="hlt">action</span> <span class="hlt">investigation</span> (<span class="hlt">CAI</span>) activities were performed from January 18 through May 5, 2005, as set forth in the Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan for Corrective <span class="hlt">Action</span> Unit 554: Area 23 Release Site (NNSA/NSO, 2004) and Records of Technical Change No. 1 and No. 2. The purpose of the <span class="hlt">CAI</span> was to fulfill the following data needs as defined during the data quality objective (DQO) process: (1) Determine whether contaminants of concern are present. (2) If contaminants of concern are present, determine their nature and extent. (3) Provide sufficient information and data to complete appropriate corrective <span class="hlt">actions</span>. The CAU 554 dataset from the <span class="hlt">investigation</span> results was evaluated based on the data quality indicator parameters. This evaluation demonstrated the quality and acceptability of the dataset for use in fulfilling the DQO data needs. Analytes detected during the <span class="hlt">CAI</span> were evaluated against preliminary <span class="hlt">action</span> levels (PALs) established in the CAU 554 CAIP for total petroleum hydrocarbons (TPH) benzo(a)pyrene, dibenz(a,h)anthracene, and trichloroethene (TCE). Specifically: (1) The soil beneath and laterally outward from former underground storage tanks at CAS 23-02-08 contains TPH-diesel-range organics (DRO) above the PAL of 100 milligrams per kilogram, confined vertically from a depth of approximately 400 feet (ft) below ground surface (bgs). The</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21490685','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21490685"><span id="translatedtitle"><span class="hlt">Investigation</span> of the peak <span class="hlt">action</span> wavelength of light-activated gene transduction.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Myakishev-Rempel, M; Kuper, J; Mintz, B; Hutchinson, S; Voris, J; Zavislan, K; Offley, S; Nardia, F B; Yaseen, Z; Yen, T; Zavislan, J M; Maloney, M D; Schwarz, E M</p> <p>2011-11-01</p> <p>Light-activated gene transduction (LAGT) is an approach to localize gene therapy via preactivation of cells with UV light, which facilitates transduction by recombinant adeno-associated virus vectors. Previous studies demonstrated that UVC induces LAGT secondary to pyrimidine dimer formation, whereas UVA induces LAGT secondary to reactive-oxygen species (ROS) generation. However, the empirical UVB boundary of these UV effects is unknown. Thus, we aimed to define the <span class="hlt">action</span> spectra for UV-induced LAGT independent of DNA damage and determine an optimal wavelength to maximize safety and efficacy. UV at 288, 311 and 320 nm produced significant dose-dependent LAGT effects, of which the maximum (800-fold) was observed with 4 kJ m⁻² at 311 nm. Consistent with its robust cytotoxicity, 288 nm produced significantly high levels of DNA damage at all doses tested, whereas 311, 320 and 330 nm did not generate pyrimidine dimers and produced low levels of DNA damage detected by comet assay. Although 288 nm failed to induce ROS, the other wavelengths were effective, with the maximum (10-fold) effect observed with 30 kJ m⁻² at 311 nm. An in vivo pilot study assessing 311 nm-induced LAGT of rabbit articular chondrocytes demonstrated a significant 6.6-fold (P<0.05) increase in transduction with insignificant cytotoxicity. In conclusion, 311 nm was found to be the optimal wavelength for LAGT on the basis of its superior efficacy at the peak dose and its broad safety range that is remarkably wider than the other UV wavelengths tested.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016ChPhB..25a8706J','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016ChPhB..25a8706J"><span id="translatedtitle">Computational <span class="hlt">investigations</span> on polymerase <span class="hlt">actions</span> in gene transcription and replication: Combining physical modeling and atomistic simulations</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Jin, Yu</p> <p>2016-01-01</p> <p>Polymerases are protein enzymes that move along nucleic acid chains and catalyze template-based polymerization reactions during gene transcription and replication. The polymerases also substantially improve transcription or replication fidelity through the non-equilibrium enzymatic cycles. We briefly review computational efforts that have been made toward understanding mechano-chemical coupling and fidelity control mechanisms of the polymerase elongation. The polymerases are regarded as molecular information motors during the elongation process. It requires a full spectrum of computational approaches from multiple time and length scales to understand the full polymerase functional cycle. We stay away from quantum mechanics based approaches to the polymerase catalysis due to abundant former surveys, while addressing statistical physics modeling approaches along with all-atom molecular dynamics simulation studies. We organize this review around our own modeling and simulation practices on a single subunit T7 RNA polymerase, and summarize commensurate studies on structurally similar DNA polymerases as well. For multi-subunit RNA polymerases that have been actively studied in recent years, we leave systematical reviews of the simulation achievements to latest computational chemistry surveys, while covering only representative studies published very recently, including our own work modeling structure-based elongation kinetic of yeast RNA polymerase II. In the end, we briefly go through physical modeling on elongation pauses and backtracking activities of the multi-subunit RNAPs. We emphasize on the fluctuation and control mechanisms of the polymerase <span class="hlt">actions</span>, highlight the non-equilibrium nature of the operation system, and try to build some perspectives toward understanding the polymerase impacts from the single molecule level to a genome-wide scale. Project supported by the National Natural Science Foundation (Grant No. 11275022).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3530381','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3530381"><span id="translatedtitle"><span class="hlt">Investigation</span> of the peak <span class="hlt">action</span> wavelength of light-activated gene transduction (LAGT)</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Myakishev-Rempel, Max; Kuper, Jerry; Mintz, Benjamin; Hutchinson, Sara; Voris, Jay; Zavislan, Katrina; Offley, Sarah; Nardia, Frances Barg; Yaseen, Zaneb; Yen, Tony; Zavislan, James; Maloney, Michael D.; Schwarz, Edward M.</p> <p>2011-01-01</p> <p>Light-activated gene transduction (LAGT) is an approach to localize gene therapy via preactivation of cells with UV light, which facilitates transduction by recombinant adeno-associated virus vectors. Prior studies demonstrated that UVC induces LAGT secondary to pyrimidine dimer formation, while UVA induces LAGT secondary to reactive oxygen species (ROS) generation. However, the empirical UVB boundary of these UV effects is unknown. Thus, we aimed to define the <span class="hlt">action</span> spectra for UV-induced LAGT independent of DNA damage, and determine an optimal wavelength to maximize safety and efficacy. Results: UV at 288, 311 and 320nm produced significant dose-dependent LAGT effects, of which the maximum (800-fold) was observed with 4kJ/m2 at 311nm. Consistent with its robust cytotoxicity, 288nm produced significantly high levels of DNA damage at all doses tested, while 311, 320 and 330nm did not generate pyrimidine dimers and produced low levels of DNA damage detected by comet assay. While 288nm failed to induce ROS, the other wavelengths were effective, with the maximum (10-fold) effect observed with 30 kJ/m2 at 311nm. An in vivo pilot study assessing 311nm-induced LAGT of rabbit articular chondrocytes demonstrated a significant 6.6-fold (p<0.05) increase in transduction with insignificant cytotoxicity. Conclusion: 311nm was found to be the optimal wavelength for LAGT based on its superior efficacy at the peak dose, and its broad safety range that is remarkably wider than the other UV wavelengths tested. PMID:21490685</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/944372','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/944372"><span id="translatedtitle">OXYGEN ISOTOPIC COMPOSITIONS OF THE ALLENDE TYPE C <span class="hlt">CAIs</span>: EVIDENCE FOR ISOTOPIC EXCHANGE DURING NEBULAR MELTING AND ASTEROIDAL THERMAL METAMORPHISM</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Krot, A N; Chaussidon, M; Yurimoto, H; Sakamoto, N; Nagashima, K; Hutcheon, I D; MacPherson, G J</p> <p>2008-02-21</p> <p>Based on the mineralogy and petrography, coarse-grained, igneous, anorthite-rich (Type C) calcium-aluminum-rich inclusions (<span class="hlt">CAIs</span>) in the CV3 carbonaceous chondrite Allende have been recently divided into three groups: (i) <span class="hlt">CAIs</span> with melilite and Al,Ti-diopside of massive and lacy textures (coarse grains with numerous rounded inclusions of anorthite) in a fine-grained anorthite groundmass (6-1-72, 100, 160), (ii) <span class="hlt">CAI</span> CG5 with massive melilite, Al,Ti-diopside and anorthite, and (iii) <span class="hlt">CAIs</span> associated with chondrule material: either containing chondrule fragments in their peripheries (ABC, TS26) or surrounded by chondrule-like, igneous rims (93) (Krot et al., 2007a,b). Here, we report in situ oxygen isotopic measurements of primary (melilite, spinel, Al,Ti-diopside, anorthite) and secondary (grossular, monticellite, forsterite) minerals in these <span class="hlt">CAIs</span>. Spinel ({Delta}{sup 17}O = -25{per_thousand} to -20{per_thousand}), massive and lacy Al,Ti-diopside ({Delta}{sup 17}O = -20{per_thousand} to -5{per_thousand}) and fine-grained anorthite ({Delta}{sup 17}O = -15{per_thousand} to -2{per_thousand}) in 100, 160 and 6-1-72 are {sup 16}O-enriched relative spinel and coarse-grained Al,Ti-diopside and anorthite in ABC, 93 and TS26 ({Delta}{sup 17}O ranges from -20{per_thousand} to -15{per_thousand}, from -15{per_thousand} to -5{per_thousand}, and from -5{per_thousand} to 0{per_thousand}, respectively). In 6-1-72, massive and lacy Al,Ti-diopside grains are {sup 16}O-depleted ({Delta}{sup 17}O {approx} -13{per_thousand}) relative to spinel ({Delta}{sup 17}O = -23{per_thousand}). Melilite is the most {sup 16}O-depleted mineral in all Allende Type C <span class="hlt">CAIs</span>. In <span class="hlt">CAI</span> 100, melilite and secondary grossular, monticellite and forsterite (minerals replacing melilite) are similarly {sup 16}O-depleted, whereas grossular in <span class="hlt">CAI</span> 160 is {sup 16}O-enriched ({Delta}{sup 17}O = -10{per_thousand} to -6{per_thousand}) relative to melilite ({Delta}{sup 17}O = -5{per_thousand} to -3{per_thousand}). We infer</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23544477','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23544477"><span id="translatedtitle">The effects of subjective time pressure and individual differences on hypotheses generation and <span class="hlt">action</span> prioritization in police <span class="hlt">investigations</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Alison, Laurence; Doran, Bernadette; Long, Matthew L; Power, Nicola; Humphrey, Amy</p> <p>2013-03-01</p> <p>When individuals perceive time pressure, they decrease the generation of diagnostic hypotheses and prioritize information. This article examines whether individual differences in (a) internal time urgency, (b) experience, and (c) fluid mental ability can moderate these effects. Police officers worked through a computer-based rape <span class="hlt">investigative</span> scenario, in which 35 were subjected to a time pressure manipulation, with their hypotheses generation and prioritization skills compared with a control (n = 41). Group 1 was told they would "get less time to complete the scenario compared with other officers," although both groups had equal amounts of time. Regression analyses found that time pressure reduced hypothesis generation and that individual differences in time urgency moderated this effect; individuals who tend to perceive time to pass more slowly than it is continued to generate hypotheses despite the presence of time pressure. Time pressure also influenced the likelihood of <span class="hlt">action</span> prioritization at the start of the <span class="hlt">investigation</span>. Time pressure was found to increase <span class="hlt">action</span> prioritization, but only for officers with low time urgency or high fluid ability. Experience had no effect on time pressure during the <span class="hlt">investigative</span> scenario. Implications of these findings are discussed. PMID:23544477</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23544477','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23544477"><span id="translatedtitle">The effects of subjective time pressure and individual differences on hypotheses generation and <span class="hlt">action</span> prioritization in police <span class="hlt">investigations</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Alison, Laurence; Doran, Bernadette; Long, Matthew L; Power, Nicola; Humphrey, Amy</p> <p>2013-03-01</p> <p>When individuals perceive time pressure, they decrease the generation of diagnostic hypotheses and prioritize information. This article examines whether individual differences in (a) internal time urgency, (b) experience, and (c) fluid mental ability can moderate these effects. Police officers worked through a computer-based rape <span class="hlt">investigative</span> scenario, in which 35 were subjected to a time pressure manipulation, with their hypotheses generation and prioritization skills compared with a control (n = 41). Group 1 was told they would "get less time to complete the scenario compared with other officers," although both groups had equal amounts of time. Regression analyses found that time pressure reduced hypothesis generation and that individual differences in time urgency moderated this effect; individuals who tend to perceive time to pass more slowly than it is continued to generate hypotheses despite the presence of time pressure. Time pressure also influenced the likelihood of <span class="hlt">action</span> prioritization at the start of the <span class="hlt">investigation</span>. Time pressure was found to increase <span class="hlt">action</span> prioritization, but only for officers with low time urgency or high fluid ability. Experience had no effect on time pressure during the <span class="hlt">investigative</span> scenario. Implications of these findings are discussed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4381844','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4381844"><span id="translatedtitle">By the sound of it. An ERP <span class="hlt">investigation</span> of human <span class="hlt">action</span> sound processing in 7-month-old infants</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Geangu, Elena; Quadrelli, Ermanno; Lewis, James W.; Macchi Cassia, Viola; Turati, Chiara</p> <p>2015-01-01</p> <p>Recent evidence suggests that human adults perceive human <span class="hlt">action</span> sounds as a distinct category from human vocalizations, environmental, and mechanical sounds, activating different neural networks (Engel et al., 2009; Lewis et al., 2011). Yet, little is known about the development of such specialization. Using event-related potentials (ERP), this study <span class="hlt">investigated</span> neural correlates of 7-month-olds’ processing of human <span class="hlt">action</span> (HA) sounds in comparison to human vocalizations (HV), environmental (ENV), and mechanical (MEC) sounds. Relative to the other categories, HA sounds led to increased positive amplitudes between 470 and 570 ms post-stimulus onset at left anterior temporal locations, while HV led to increased negative amplitudes at the more posterior temporal locations in both hemispheres. Collectively, human produced sounds (HA + HV) led to significantly different response profiles compared to non-living sound sources (ENV + MEC) at parietal and frontal locations in both hemispheres. Overall, by 7 months of age human <span class="hlt">action</span> sounds are being differentially processed in the brain, consistent with a dichotomy for processing living versus non-living things. This provides novel evidence regarding the typical categorical processing of socially relevant sounds. PMID:25732377</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/789217','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/789217"><span id="translatedtitle">Addendum to Revision 1 of the Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan for Corrective <span class="hlt">Action</span> Unit 98: Frenchman Flat, Nevada Test Site, Nevada (Addendum Revision No. 1)</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office</p> <p>2001-06-06</p> <p>This document is submitted as an addendum to the Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan (CAIP) for Corrective <span class="hlt">Action</span> Unit (CAU) 98: Frenchman Flat, Nevada Test Site (NTS), Nevada. The addendum was prepared to propose work activities in response to comments resulting from the U.S. Department of Energy's (DOE's) review of the draft Frenchman Flat CAU model of groundwater flow and contaminant transport completed in April 1999. The reviewers included an external panel of experts and the Nevada Division of Environmental Protection. As a result of the review, additional work scope, including new data-collection and modeling activities, has been identified for the Frenchman Flat CAU. The proposed work scope described in this addendum will be conducted in accordance with the revised Underground Test Area strategy contained in the December 2000 amendment to the Federal Facility Agreement and Consent Order. The Frenchman Flat CAU model is a group of interdependent models designed to predict the extent of contamination in groundwater due to the underground nuclear tests conducted within this CAU. At the time of the DOE review, the CAU model consisted of a CAU groundwater flow and transport model comprised of two major components: a groundwater flow model and a recharge model. The CAU groundwater flow model is supported by a hydrostratigraphic model and a recharge model, whereas the CAU transport model is supported by a source-term model. As part of the modeling activities proposed in this addendum, two new major components may be added to the Frenchman Flat CAU model: a total-system model and two local groundwater flow and transport models. The reviewers identified several issues relating to insufficiency of data and inadequacy of the modeling process that should be addressed to provide additional confidence in the modeling results with respect to the potential for contaminant migration to the Lower Carbonate Aquifer. The proposed additional work scope includes new data</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li class="active"><span>17</span></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_17 --> <div id="page_18" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li class="active"><span>18</span></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="341"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/1022621','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/1022621"><span id="translatedtitle">Corrective <span class="hlt">Action</span> Decision Document/Corrective <span class="hlt">Action</span> Plan for Corrective <span class="hlt">Action</span> Unit 98: Frenchman Flat, Nevada National Security Site, Nevada, Revision 1</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Irene Farnham and Sam Marutzky</p> <p>2011-07-01</p> <p>This CADD/CAP follows the Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> (<span class="hlt">CAI</span>) stage, which results in development of a set of contaminant boundary forecasts produced from groundwater flow and contaminant transport modeling of the Frenchman Flat CAU. The Frenchman Flat CAU is located in the southeastern portion of the NNSS and comprises 10 underground nuclear tests. The tests were conducted between 1965 and 1971 and resulted in the release of radionuclides in the subsurface in the vicinity of the test cavities. Two important aspects of the corrective <span class="hlt">action</span> process are presented within this CADD/CAP. The CADD portion describes the results of the Frenchman Flat CAU data-collection and modeling activities completed during the <span class="hlt">CAI</span> stage. The corrective <span class="hlt">action</span> objectives and the <span class="hlt">actions</span> recommended to meet the objectives are also described. The CAP portion describes the corrective <span class="hlt">action</span> implementation plan. The CAP begins with the presentation of CAU regulatory boundary objectives and initial use restriction boundaries that are identified and negotiated by NNSA/NSO and the Nevada Division of Environmental Protection (NDEP). The CAP also presents the model evaluation process designed to build confidence that the flow and contaminant transport modeling results can be used for the regulatory decisions required for CAU closure. The first two stages of the strategy have been completed for the Frenchman Flat CAU. A value of information analysis and a CAIP were developed during the CAIP stage. During the <span class="hlt">CAI</span> stage, a CAIP addendum was developed, and the activities proposed in the CAIP and addendum were completed. These activities included hydrogeologic <span class="hlt">investigation</span> of the underground testing areas, aquifer testing, isotopic and geochemistry-based <span class="hlt">investigations</span>, and integrated geophysical <span class="hlt">investigations</span>. After these <span class="hlt">investigations</span>, a groundwater flow and contaminant transport model was developed to forecast contaminant boundaries that enclose areas potentially exceeding the Safe Drinking</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/891961','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/891961"><span id="translatedtitle">Corrective <span class="hlt">Action</span> Decision Document/Closure Report for Corrective <span class="hlt">Action</span> Unit 219: Septic Systems and Injection Wells, Nevada Test Site, Nevada, Rev. No.: 0</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>David Strand</p> <p>2006-05-01</p> <p>This Corrective <span class="hlt">Action</span> Decision Document/Closure Report has been prepared for Corrective <span class="hlt">Action</span> Unit (CAU) 219, Septic Systems and Injection Wells, in Areas 3, 16, and 23 of the Nevada Test Site, Nevada, in accordance with the ''Federal Facility Agreement and Consent Order'' (1996). Corrective <span class="hlt">Action</span> Unit 219 is comprised of the following corrective <span class="hlt">action</span> sites (CASs): (1) 03-11-01, Steam Pipes and Asbestos Tiles; (2) 16-04-01, Septic Tanks (3); (3) 16-04-02, Distribution Box; (4) 16-04-03, Sewer Pipes; (5) 23-20-01, DNA Motor Pool Sewage and Waste System; and (6) 23-20-02, Injection Well. The purpose of this Corrective <span class="hlt">Action</span> Decision Document/Closure Report is to provide justification and documentation supporting the recommendation for closure of CAU 219 with no further corrective <span class="hlt">action</span> beyond the application of a use restriction at CASs 16-04-01, 16-04-02, and 16-04-03. To achieve this, corrective <span class="hlt">action</span> <span class="hlt">investigation</span> (<span class="hlt">CAI</span>) activities were performed from June 20 through October 12, 2005, as set forth in the CAU 219 Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan and Record of Technical Change No. 1. A best management practice was implemented at CASs 16-04-01, 16-04-02, and 16-04-03, and corrective <span class="hlt">action</span> was performed at CAS 23-20-01 between January and April 2006. In addition, a use restriction will be applied to CASs 16-04-01, 16-04-02, and 16-04-03 to provide additional protection to Nevada Test Site personnel. The purpose of the <span class="hlt">CAI</span> was to fulfill the following data needs as defined during the data quality objective (DQO) process: (1) Determine whether contaminants of concern (COCs) are present. (2) If COCs are present, determine their nature and extent. (3) Provide sufficient information and data to complete appropriate corrective <span class="hlt">actions</span>. The CAU 219 dataset from the <span class="hlt">investigation</span> results was evaluated based on the data quality indicator parameters. This evaluation demonstrated the quality and acceptability of the dataset for use in fulfilling the DQO data needs</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/891959','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/891959"><span id="translatedtitle">Corrective <span class="hlt">Action</span> Decision Document for Corrective <span class="hlt">Action</span> Unit 151: Septic Systems and Discharge Area, Nevada Test Site, Nevada, Rev. No.: 0</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Grant Evenson</p> <p>2006-05-01</p> <p>This Corrective <span class="hlt">Action</span> Decision Document has been prepared for Corrective <span class="hlt">Action</span> Unit (CAU) 151, Septic Systems and Discharge Area, at the Nevada Test Site, Nevada, according to the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996). Corrective <span class="hlt">Action</span> Unit 151 is comprised of eight corrective <span class="hlt">action</span> sites (CASs): (1) CAS 02-05-01, UE-2ce Pond; (2) CAS 12-03-01, Sewage Lagoons (6); (3) CAS 12-04-01, Septic Tanks; (4) CAS 12-04-02, Septic Tanks; (5) CAS 12-04-03, Septic Tank; (6) CAS 12-47-01, Wastewater Pond; (7) CAS 18-03-01, Sewage Lagoon; and (8) CAS 18-99-09, Sewer Line (Exposed). The purpose of this Corrective <span class="hlt">Action</span> Decision Document is to identify and provide the rationale for the recommendation of corrective <span class="hlt">action</span> alternatives (CAAs) for each of the eight CASs within CAU 151. Corrective <span class="hlt">action</span> <span class="hlt">investigation</span> (<span class="hlt">CAI</span>) activities were performed from September 12 through November 18, 2005, as set forth in the CAU 151 Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan and Record of Technical Change No. 1. Additional confirmation sampling was performed on December 9, 2005; January 10, 2006; and February 13, 2006. Analytes detected during the <span class="hlt">CAI</span> were evaluated against appropriate final <span class="hlt">action</span> levels (FALs) to identify the contaminants of concern for each CAS. The results of the <span class="hlt">CAI</span> identified contaminants of concern at two of the eight CASs in CAU 151 and required the evaluation of CAAs. Assessment of the data generated from <span class="hlt">investigation</span> activities conducted at CAU 151 revealed the following: (1) Soils at CASs 02-05-01, 12-04-01, 12-04-02, 12-04-03, 12-47-01, 18-03-01, 18-99-09, and Lagoons B through G of CAS 12-03-01 do not contain contamination at concentrations exceeding the FALs. (2) Lagoon A of CAS 12-03-01 has arsenic above FALs in shallow subsurface soils. (3) One of the two tanks of CAS 12-04-01, System No.1, has polychlorinated biphenyls (aroclor-1254), trichloroethane, and cesium-137 above FALs in the sludge. Both CAS 12-04-01, System No.1 tanks contain</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2009AGUFM.V43J..02O','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2009AGUFM.V43J..02O"><span id="translatedtitle">The isotopic homogeneity in the early solar system: Revisiting the <span class="hlt">CAI</span> oxygen isotopic anomaly</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ozima, M.; Yamada, A.</p> <p>2009-12-01</p> <p>Since the first discovery of the mass-independently fractionated oxygen isotopes in anhydrous, high temperature Ca-Al rich inclusion minerals in carbonaceous meteorites (<span class="hlt">CAIs</span>) by Clayton et al. (1), their common occurrence in primitive meteorites has generally been regarded to reflect some fundamental process prevalent in the early solar nebula. The <span class="hlt">CAI</span> oxygen isotopic composition is uniquely characterized by (i) large mass independent isotopic fractionation and (ii) their isotopic data in an oxygen three isotope plot (δ17O - δ18O (δ17O ≡ {(17O/16O)/(17O/16O)SMOW - 1} × 1000) yield nearly a straight line with a slope 1.0. In establishing these characteristics, ion microprobe analyses has played a central role, especially an isotopic mapping technique (isotopography) was crucial (e.g., 2). The extraordinary oxygen isotopic ratio in <span class="hlt">CAIs</span> is widely attributed to the self-shielding absorption of UV radiation in CO, one of the dominant chemical compounds in the early solar nebula (3). However, the self-shielding scenario necessarily leads to the unusual prediction that a mean solar oxygen isotopic composition differs from most of planetary bodies including Earth, Moon, and Mars. If the self-shielding process were indeed responsible to the <span class="hlt">CAI</span> oxygen isotopic anomaly, this would require a fundamental revision of the current theory of the origin of the solar system, which generally assumes the initial total vaporization of nebula material to give rise to isotopic homogenization. The GENESIS mission launched in 2001(4), which collected oxygen in the solar wind was hoped to resolve the isotopic composition of the Sun. However, because of difficulties in correcting for instrumental and more importantly for intrinsic isotopic fractionation between the SW and the Sun, a final answer is yet to be seen (5). Here, we show on the basis of the oxygen isotopic fractionation systematics that the self shielding hypothesis cannot explain the key characteristics of the <span class="hlt">CAI</span> oxygen</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1008645','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1008645"><span id="translatedtitle">Microbial and immunological <span class="hlt">investigations</span> and remedial <span class="hlt">action</span> after an outbreak of humidifier fever</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Edwards, J H</p> <p>1980-01-01</p> <p> outbreaks was obtained, which suggested a common antigen source in humidifier fever. That these antigens were produced by microbial development on rayon fibre could be shown by incubating rayon dust from the factory atmosphere with sterile water and testing with sera from affected individuals. Bales of rayon entering the factory did not have this potential to develop antigens, indicating microbial contamination after handling and processing. The initial source of contamination was considered to be the humidifier disseminating microbial spores and cysts throughout the factory and on to the suspended ceiling above the office. These were capable of secondary development on settled rayon fly under wet conditions, and evidence for this was obtained. Remedial <span class="hlt">action</span> included cleaning the humidifier, modifying the baffle plates, running water to waste, and installing a prefilter. Dust was eliminated from the office area, and new accommodation, including the building of an office block detached from the main factory, was arranged for the office workers. So far no further cases have been reported. Images PMID:6768379</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/891956','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/891956"><span id="translatedtitle">Streamlined Approach for Environmental Restoration (SAFER) Plan for Corrective <span class="hlt">Action</span> Unit 538: Spill Sites, Nevada Test Site, Nevada, Rev. No.: 0</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Alfred Wickline</p> <p>2006-04-01</p> <p>This Streamlined Approach for Environmental Restoration (SAFER) Plan addresses the <span class="hlt">actions</span> necessary for the closure of Corrective <span class="hlt">Action</span> Unit (CAU) 538: Spill Sites, Nevada Test Site, Nevada. It has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996) that was agreed to by the State of Nevada, the U.S. Department of Energy (DOE), and the U.S. Department of Defense. A SAFER may be performed when the following criteria are met: (1) Conceptual corrective <span class="hlt">actions</span> are clearly identified (although some degree of <span class="hlt">investigation</span> may be necessary to select a specific corrective <span class="hlt">action</span> before completion of the Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> [<span class="hlt">CAI</span>]). (2) Uncertainty of the nature, extent, and corrective <span class="hlt">action</span> must be limited to an acceptable level of risk. (3) The SAFER Plan includes decision points and criteria for making data quality objective (DQO) decisions. The purpose of the <span class="hlt">investigation</span> will be to document and verify the adequacy of existing information; to affirm the decision for either clean closure, closure in place, or no further <span class="hlt">action</span>; and to provide sufficient data to implement the corrective <span class="hlt">action</span>. The actual corrective <span class="hlt">action</span> selected will be based on characterization activities implemented under this SAFER Plan. This SAFER Plan identifies decision points developed in cooperation with the Nevada Division of Environmental Protection (NDEP) and where DOE will reach consensus with NDEP before beginning the next phase of work.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016EGUGA..18.5734Z','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016EGUGA..18.5734Z"><span id="translatedtitle">Study on remote sensing of aerosols over land using TANSO-<span class="hlt">CAI</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Zhong, Guosheng; Wang, Xiufeng; Yin, Shuai; Sun, Zhongyi; Tani, Hiroshi</p> <p>2016-04-01</p> <p>The Cloud and Aerosol Imager (<span class="hlt">CAI</span>) is one of the subunits of observation instrument Thermal And Near-infrared Sensor for carbon Observation (TANSO) onboard the GOSAT, and is used to observe aerosol optical properties and clouds. TANSO-<span class="hlt">CAI</span> includes 4 bands (370~390 nm, 668~688 nm, 860~880 nm and 1560~1680 nm), bands 1 to 3 have a 0.5-km spatial resolution at the nadir and 1000-km observation swath. The spatial resolution and swath of band 4 are 1.5 km and 750 km, respectively. In this study, it was assumed that the surface reflectance at 670 nm can be obatined using an empirical relationship between the reflectances at 670 nm and at 1600 nm. For analyzing the empirical relationship, dark fields were selected from the GOSAT-<span class="hlt">CAI</span> data, where AERONET sun photometer measurements were available within 30 minutes, the distance from the AERONET station was within 30 km, and the AOD at 550 nm was below 0.1. The surface reflectance was derived by atmospheric correction with the Second Simulation of a Satellite Signal in the Solar Spectrum (6S) radiative transfer model and AERONET AOD. A regression function between top-of-atmosphere reflectances at 1600 nm and surface reflectances at 670 nm was summarized. AODs were retrieved using a look-up table method and compared with AERONET AODs. The results show that more than 70% validating data are located within expected errors for MODIS (±0.05 ±0.15τ, τ is AOD).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20150018570','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20150018570"><span id="translatedtitle">Characterization of Meteorites by Focused Ion Beam Sectioning: Recent Applications to <span class="hlt">CAIs</span> and Primitive Meteorite Matrices</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Christoffersen, Roy; Keller, Lindsay P.; Han, Jangmi; Rahman, Zia; Berger, Eve L.</p> <p>2015-01-01</p> <p>Focused ion beam (FIB) sectioning has revolutionized preparation of meteorite samples for characterization by analytical transmission electron microscopy (TEM) and other techniques. Although FIB is not "non-destructive" in the purest sense, each extracted section amounts to no more than nanograms (approximately 500 cubic microns) removed intact from locations precisely controlled by SEM imaging and analysis. Physical alteration of surrounding material by ion damage, fracture or sputter contamination effects is localized to within a few micrometers around the lift-out point. This leaves adjacent material intact for coordinate geochemical analysis by SIMS, microdrill extraction/TIMS and other techniques. After lift out, FIB sections can be quantitatively analyzed by electron microprobe prior to final thinning, synchrotron x-ray techniques, and by the full range of state-of-the-art analytical field-emission scanning transmission electron microscope (FE-STEM) techniques once thinning is complete. Multiple meteorite studies supported by FIB/FE-STEM are currently underway at NASA-JSC, including coordinated analysis of refractory phase assemblages in <span class="hlt">CAIs</span> and fine-grained matrices in carbonaceous chondrites. FIB sectioning of <span class="hlt">CAIs</span> has uncovered epitaxial and other overgrowth relations between corundum-hibonite-spinel consistent with hibonite preceding corundum and/or spinel in non-equilibrium condensation sequences at combinations of higher gas pressures, dust-gas enrichments or significant nebular transport. For all of these cases, the ability of FIB to allow for coordination with spatially-associated isotopic data by SIMS provides immense value for constraining the formation scenarios of the particular <span class="hlt">CAI</span> assemblage. For carbonaceous chondrites matrix material, FIB has allowed us to obtain intact continuous sections of the immediate outer surface of Murchison (CM2) after it has been experimentally ion processed to simulate solar wind space weathering. The surface</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1981iit..rept.....G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1981iit..rept.....G"><span id="translatedtitle"><span class="hlt">Investigation</span> of molecular mechanisms in photodynamic <span class="hlt">action</span> and radiobiology with nanosecond flash photolysis and pulse radiolysis</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Grossweiner, L. I.</p> <p>1981-06-01</p> <p>A formula was proposed for predicting enzyme inactivation quantum yields. The predictions were in good agreement with measurements on six important enzymes at 254 nm and 280 nm. Kinetics models were developed and tested for important stages in the photosensitization of DNA to near ultraviolet radiation by furocoumarin compounds currently used for PUVA therapy (psoralen plus UV-A) of psoriasis and other human skin diseases. Experiments on photobinding of psoralen (Ps) and 8-methoxypsoralen (8-MOP) to calf thymus DNA were consistent with the assumption that equilibrium dark complexing of the furocoumarin to the DNA is a precondition for the formation of covalent monoadducts and crosslinks. Singlet oxygen generation by furocoumarins has been <span class="hlt">investigated</span> with liposomes and human erythrocytes (rbc). Results were obtained with 3-carbethoxypsoralen (3-CPs), and experimental alternate interacts with liposome and rbc membranes in the dark.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/20797968','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/20797968"><span id="translatedtitle">Optical <span class="hlt">Investigations</span> of Powerful Laser <span class="hlt">Actions</span> on Massive and Flyer Targets</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Pisarczyk, T.; Borodziuk, S.; Kasperczuk, A.; Demchenko, N. N.; Gus'kov, S. Yu.; Jungwirth, K.; Kralikova, B.; Krousky, E.; Masek, K.; Pfeifer, M.; Rohlena, K.; Rozanov, V. B.; Skala, J.; Ullschmied, J.; Kalal, M.; Limpouch, J.; Pisarczyk, P.</p> <p>2006-01-15</p> <p>In this paper we present experimental, theoretical, and computer simulation studies of craters formation produced by high power lasers in single and double layer targets. The experimental <span class="hlt">investigation</span> was carried out using the PALS (Prague Asterix Laser System) facility working with two different laser beam wavelengths: {lambda}1 = 1.315 {mu}m and {lambda}3 0.438 {mu}m. Two types of targets made of Al were used: single massive targets, and double targets consisting of a foil or disk (6 {mu}m thick for both cases) placed in front of the massive target part at a distance of 200-500 {mu}m. Experiments with single massive targets were performed at laser intensities in the range of 1013-1015 W/cm2 by varying the laser beam diameters on the target surface from 70 {mu}m up to 1200 {mu}m (i.e. moving the target away from the focus). The double targets were illuminated by laser energies EL = 100-500 J focused always on a diameter of 250 {mu}m. In all experiments performed the laser pulse duration was equal to 400 ps. 3-frame interferometry was employed to <span class="hlt">investigate</span> the plasma dynamics through measurements of the electron density distribution time development as well as of the disks and foil fragments velocities. The dimensions and shapes of craters were obtained by crater replica technology and microscopy measurement. The experiments were complemented by a 2-D analytical theory and computer simulations, which helped at interpretation of the results. This way the values of laser energy absorption coefficient, ablation loading efficiency and efficiency of energy transfer, as well as two-dimensional shock wave generation at the laser-driven macroparticle impact were obtained from the measured crater parameters for both the wavelengths of laser radiation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015AGUFMPA13A2163O','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015AGUFMPA13A2163O"><span id="translatedtitle">A multi-agency <span class="hlt">investigation</span> of Heat and human Health relationships in the state of Vermont: Towards <span class="hlt">actionable</span> science.</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Oswald, E.</p> <p>2015-12-01</p> <p>This talk focuses on an assemblage of work conducted primarily between the Vermont State Climate Office and the Vermont Department of Health for better understanding, communicating, and anticipating the impact which elevated air temperatures have, and my have in the future, on public health. This is an example in how several agencies, spanning scientific fields and levels, can all play roles in in producing important understanding and <span class="hlt">actionable</span> consequences in the face of health risk. This talk starts with an <span class="hlt">investigation</span> of the relationships between Vermont health statistics and daily maximum air temperature with a focus on the temperatures where the health statistics changed most rapidly with temperature changes, or "changepoints". The results of this <span class="hlt">investigation</span> suggested that meaningful temperature changepoints exist below 90F. The local WFO considered a day as "hot" when it reached or exceeded 90F unless the day was particularly sunny and humid. Discussions with the local National Weather Service Forecast Office were productive and led to some rethinking of how they consider a "Hot" day. The changepoints information was also incorporated into a health impacts report prepared by the Vermont Department of Health for the CDC's Building Resilience Against Climate Effects, by utilizing climate indices tailored to a temperature less than 90F. This work stands as a demonstration that the co-production of knowledge can produce <span class="hlt">actionable</span> science.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/19479241','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/19479241"><span id="translatedtitle">Gastroprotective activity of isopulegol on experimentally induced gastric lesions in mice: <span class="hlt">investigation</span> of possible mechanisms of <span class="hlt">action</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Silva, Maria Izabel Gomes; Moura, Brinell Arcanjo; Neto, Manuel Rufino de Aquino; Tomé, Adriana da Rocha; Rocha, Nayrton Flávio Moura; de Carvalho, Alyne Mara Rodrigues; Macêdo, Danielle Silveira; Vasconcelos, Silvânia Maria Mendes; de Sousa, Damião Pergentino; Viana, Glauce Socorro de Barros; de Sousa, Francisca Cléa Florenço</p> <p>2009-09-01</p> <p>The present study <span class="hlt">investigated</span> whether isopulegol, a monoterpene present in essential oils of several aromatic plants, would be able to promote some gastroprotective effect and also verified the possible mechanisms involved in this <span class="hlt">action</span>. For this study, ethanol- and indomethacin-induced gastric ulcer models in mice and histopathological assessment were used. The roles of NO, sulfhydryls (glutathione, GSH), ATP-sensitive K(+) channels (K(ATP) channels), and prostaglandins were also <span class="hlt">investigated</span>. Isopulegol exhibited a dose-related gastroprotective effect against ethanol-induced lesions, while the pretreatment with glibenclamide and indomethacin [but not with N(G)-nitro-L-arginine methyl ester] were able to reverse this <span class="hlt">action</span>. The pretreatment with isopulegol also restored GSH levels to normal levels and exhibited dose-related gastroprotective effect against indomethacin-induced ulcer. The results suggested that isopulegol presents significant gastroprotective effects in both ethanol- and indomethacin-induced ulcer models, which appear to be mediated, at least in part, by endogenous prostaglandins, K(ATP) channel opening, and antioxidant properties. PMID:19479241</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015GeCoA.169...99K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015GeCoA.169...99K"><span id="translatedtitle">26Al-26Mg chronology and oxygen isotope distributions of multiple melting for a Type C <span class="hlt">CAI</span> from Allende</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kawasaki, Noriyuki; Kato, Chizu; Itoh, Shoichi; Wakaki, Shigeyuki; Ito, Motoo; Yurimoto, Hisayoshi</p> <p>2015-11-01</p> <p>Disequilibrium oxygen isotopic distributions of Ca-Al-rich inclusions (<span class="hlt">CAIs</span>) correspond to multiple melting events in the solar nebula. 26Al-26Mg systematics may be applicable for age differences among such melting events. We have carried out a coordinated study of detailed petrographic observations and in-situ oxygen and magnesium isotope measurements for a Type C <span class="hlt">CAI</span>, EK1-04-2, from the Allende CV3 meteorite to determine the melting events and their ages. The <span class="hlt">CAI</span> consists mainly of spinel, anorthite, olivine, and pyroxene, and has a core and mantle structure. Petrography of the core suggests that the crystallization sequence of the core minerals is from spinel, anorthite, olivine, and to pyroxene. The mantle has the same mineral assemblage as the core, and shows incomplete melting and solidification textures. Oxygen isotopic compositions of the minerals are distributed along the carbonaceous chondrite anhydrous mineral (CCAM) line (δ18O = -44‰ to +9‰), which indicates to preserve a chemical disequilibrium status in the <span class="hlt">CAI</span>. Spinel shows a 16O-rich signature (δ18O ∼ -43‰), while anorthite is 16O-poor (δ18O ∼ +8‰). Olivine and pyroxene in the core have the same oxygen isotopic composition (δ18O ∼ -15‰), which indicates their equilibrium. Olivine and pyroxene in the mantle have variable oxygen isotopic compositions and are slightly depleted in 16O (δ18O = -13‰ to -4‰) compared with the same minerals in the core. The 26Al-26Mg systematics is consistent with the disequilibrium status observed according to the petrography and oxygen isotopes. Spinel is plotted on a line of (26Al/27Al)0 = (3.5 ± 0.2) × 10-5, anorthite is plotted on a line of (-1 ± 5) × 10-7, and olivine and pyroxene in the core are plotted on a line of (-1 ± 7) × 10-6. Plots of olivine and pyroxene in the mantle are scattered below the isochron of these minerals in the core. This study indicates that the EK1-04-2 Type C <span class="hlt">CAI</span> underwent multiple heating events after the</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013ApJ...763L..33G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013ApJ...763L..33G"><span id="translatedtitle">Variable and Extreme Irradiation Conditions in the Early Solar System Inferred from the Initial Abundance of 10Be in Isheyevo <span class="hlt">CAIs</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Gounelle, Matthieu; Chaussidon, Marc; Rollion-Bard, Claire</p> <p>2013-02-01</p> <p>A search for short-lived 10Be in 21 calcium-aluminum-rich inclusions (<span class="hlt">CAIs</span>) from Isheyevo, a rare CB/CH chondrite, showed that only 5 <span class="hlt">CAIs</span> had 10B/11B ratios higher than chondritic correlating with the elemental ratio 9Be/11B, suggestive of in situ decay of this key short-lived radionuclide. The initial (10Be/9Be)0 ratios vary between ~10-3 and ~10-2 for <span class="hlt">CAI</span> 411. The initial ratio of <span class="hlt">CAI</span> 411 is one order of magnitude higher than the highest ratio found in CV3 <span class="hlt">CAIs</span>, suggesting that the more likely origin of <span class="hlt">CAI</span> 411 10Be is early solar system irradiation. The low (26Al/27Al)0 [<= 8.9 × 10-7] with which <span class="hlt">CAI</span> 411 formed indicates that it was exposed to gradual flares with a proton fluence of a few 1019 protons cm-2, during the earliest phases of the solar system, possibly the infrared class 0. The irradiation conditions for other <span class="hlt">CAIs</span> are less well constrained, with calculated fluences ranging between a few 1019 and 1020 protons cm-2. The variable and extreme value of the initial 10Be/9Be ratios in carbonaceous chondrite <span class="hlt">CAIs</span> is the reflection of the variable and extreme magnetic activity in young stars observed in the X-ray domain.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1993Metic..28Q.335C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1993Metic..28Q.335C"><span id="translatedtitle">Thermal Histories of PGE-rich Metal Particles in a Vigarano <span class="hlt">CAI</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Casanova, I.; Grossman, L.</p> <p>1993-07-01</p> <p>Metal particles in Vigarano 1623-8, a Type B2 <span class="hlt">CAI</span> [1], underwent virtually no sulfidation, as is typical of opaque assemblages from Ca, Al-rich inclusions in the reduced CV3 chondrites [2]. In this study, we have identified two large metal grains (M1 and M2) with chemical and mineralogical features that may indicate cooling under different conditions and are, therefore, difficult to understand in the environment of a single <span class="hlt">CAIs</span> thermal evolution. M1 is an almost spherical, kamacite+taenite-bearing particle included in a fassaite grain of the <span class="hlt">CAI</span> host; a 17.5 micrometer-long (0.5 micrometer steps) microprobe traverse along M1 shows that Ni and Ru contents in the taenite (31.5 and 1.1 wt%, respectively) are uniform, and differ from those in the adjacent kamacite (Ni=4.5, Ru=0.7 wt%). M2 is a 20 micrometer, irregularly-shaped taenite particle, embedded in a fine-grained (spinel-rich) portion of 1623-8. It has a homogeneous composition with 10.5 wt% Ni, 0.4% Co, 0.7% Re, 0.6% Pt and high concentrations of Ru (6.5 wt%), Os (4.3 wt%) and Ir (8.2 wt%), as previously recognized by [1]. The composition of M2 is such that it should have undergone exsolution at 800 = T >= 600 degrees C (according to experimental data by [3]) to form at least two (alpha+gamma-NiFe), or probably three (+epsilon-RuFe) different phases. Lack of exsolution features in this large grain is therefore indicative of equilibration at relatively high temperatures (T>600 degrees C) followed by rapid cooling. Other metal particles of similar bulk compositions in <span class="hlt">CAIs</span> from the Leoville chondrite (also a reduced CV3) show extensive exsolution features that have been interpreted as the result of low- temperature equilibration of the <span class="hlt">CAI</span> and their constituents after incorporation into their parent body [4, 5]. The relatively high equilibration temperature of M2 is, however, inconsistent with the existence of kamacite in M1. From the phase relations in the Fe-Ni binary, a grain like M1, with 25 wt% bulk Ni</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/1807767','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/1807767"><span id="translatedtitle">Hypertext and three-dimensional computer graphics in an all digital PC-based <span class="hlt">CAI</span> workstation.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Schwarz, D L; Wind, G G</p> <p>1991-01-01</p> <p>In the past several years there has been an enormous increase in the number of computer-assisted instructional (<span class="hlt">CAI</span>) applications. Many medical educators and physicians have recognized the power and utility of hypertext. Some developers have incorporated simple diagrams, scanned monochrome graphics or still frame photographs from a laser disc or CD-ROM into their hypertext applications. These technologies have greatly increased the role of the microcomputer in education and training. There still remain numerous applications for these tools which are yet to be explored. One of these exciting areas involves the use of three-dimensional computer graphics. An all digital platform increases application portability.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2009gdca.conf..321C&link_type=ABSTRACT','NASAADS'); return false;" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2009gdca.conf..321C&link_type=ABSTRACT"><span id="translatedtitle">Problem Solving Process Research of Everyone Involved in Innovation Based on <span class="hlt">CAI</span> Technology</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Chen, Tao; Shao, Yunfei; Tang, Xiaowo</p> <p></p> <p>It is very important that non-technical department personnel especially bottom line employee serve as innovators under the requirements of everyone involved in innovation. According the view of this paper, it is feasible and necessary to build everyone involved in innovation problem solving process under Total Innovation Management (TIM) based on the Theory of Inventive Problem Solving (TRIZ). The tools under the <span class="hlt">CAI</span> technology: How TO mode and science effects database could be very useful for all employee especially non-technical department and bottom line for innovation. The problem solving process put forward in the paper focus on non-technical department personnel especially bottom line employee for innovation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014E%26PSL.401..327B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014E%26PSL.401..327B"><span id="translatedtitle">An oxygen isotope study of Wark-Lovering rims on type A <span class="hlt">CAIs</span> in primitive carbonaceous chondrites</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Bodénan, Jean-David; Starkey, Natalie A.; Russell, Sara S.; Wright, Ian P.; Franchi, Ian A.</p> <p>2014-09-01</p> <p>Calcium-aluminium-rich Inclusions (<span class="hlt">CAIs</span>) and the thin Wark-Lovering (WL) rims of minerals surrounding them offer a record of the nature of changing conditions during the earliest stages of Solar System formation. Considerable heterogeneity in the gas composition in the immediate vicinity of the proto-Sun had previously been inferred from oxygen isotopic variations in the WL rim of a <span class="hlt">CAI</span> from Allende (Simon et al., 2011). However, high precision and high spatial resolution oxygen isotope measurements presented in this study show that WL rim and pristine core minerals of individual <span class="hlt">CAIs</span> from meteorites that had experienced only low degrees of alteration or low grade metamorphism (one from Léoville (reduced CV3), two in QUE 99177 (CR3.0) and two in ALHA 77307 (CO3.0)) are uniformly 16O-rich. This indicates that the previously observed variations are the result of secondary processes, most likely on the asteroid parent body, and that there were no temporal or spatial variations in oxygen isotopic composition during <span class="hlt">CAI</span> and WL rim formation. Such homogeneity across three groups of carbonaceous chondrites lends further support for a common origin for the <span class="hlt">CAIs</span> in all chondrites. 16O-poor oxygen reservoirs such as those associated with chondrule formation, were probably generated by UV photo-dissociation involving self-shielding mechanisms and must have occurred elsewhere in outer regions of the solar accretion disk.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/907835','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/907835"><span id="translatedtitle">Constraints on the Origin of Chondrules and <span class="hlt">CAIs</span> from Short-Lived and Long-Lived Radionuclides</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Kita, N T; Huss, G R; Tachibana, S; Amelin, Y; Nyquist, L E; Hutcheon, I D</p> <p>2005-10-24</p> <p>The high time resolution Pb-Pb ages and short-lived nuclide based relative ages for <span class="hlt">CAIs</span> and chondrules are reviewed. The solar system started at 4567.2 {+-} 0.6Ma inferred from the high precision Pb-Pb ages of <span class="hlt">CAIs</span>. Time scales of <span class="hlt">CAIs</span> ({le}0.1Myr), chondrules (1-3Myr), and early asteroidal differentiation ({ge}3Myr) inferred from {sup 26}Al relative ages are comparable to the time scale estimated from astronomical observations of young star; proto star, classical T Tauri star and week-lined T Tauri star, respectively. Pb-Pb ages of chondrules also indicate chondrule formation occur within 1-3 Myr after <span class="hlt">CAIs</span>. Mn-Cr isochron ages of chondrules are similar to or within 2 Myr after <span class="hlt">CAI</span> formation. Chondrules from different classes of chondrites show the same range of {sup 26}Al ages in spite of their different oxygen isotopes, indicating that chondrule formed in the localized environment. The {sup 26}Al ages of chondrules in each chondrite class show a hint of correlation with their chemical compositions, which implies the process of elemental fractionation during chondrule formation events.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/818649','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/818649"><span id="translatedtitle">Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan for Corrective <span class="hlt">Action</span> Unit 527: Horn Silver Mine, Nevada Test Site, Nevada: Revision 1 (Including Records of Technical Change No.1, 2, 3, and 4)</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office</p> <p>2002-12-06</p> <p>This Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan contains the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Operations Office's approach to collect the data necessary to evaluate corrective <span class="hlt">action</span> alternatives appropriate for the closure of Corrective <span class="hlt">Action</span> Unit (CAU) 527, Horn Silver Mine, Nevada Test Site, Nevada, under the Federal Facility Agreement and Consent Order. Corrective <span class="hlt">Action</span> Unit 527 consists of one Corrective <span class="hlt">Action</span> Site (CAS): 26-20-01, Contaminated Waste Dump No.1. The site is located in an abandoned mine site in Area 26 (which is the most arid part of the NTS) approximately 65 miles northwest of Las Vegas. Historical documents may refer to this site as CAU 168, CWD-1, the Wingfield mine (or shaft), and the Wahmonie mine (or shaft). Historical documentation indicates that between 1959 and the 1970s, nonliquid classified material and unclassified waste was placed in the Horn Silver Mine's shaft. Some of the waste is known to be radioactive. Documentation indicates that the waste is present from 150 feet to the bottom of the mine (500 ft below ground surface). This CAU is being <span class="hlt">investigated</span> because hazardous constituents migrating from materials and/or wastes disposed of in the Horn Silver Mine may pose a threat to human health and the environment as well as to assess the potential impacts associated with any potential releases from the waste. The results of this field <span class="hlt">investigation</span> will support a defensible evaluation of corrective <span class="hlt">action</span> alternatives in the corrective <span class="hlt">action</span> decision document.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li class="active"><span>18</span></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_18 --> <div id="page_19" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active"><span>19</span></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="361"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013PhDT.......156F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013PhDT.......156F"><span id="translatedtitle"><span class="hlt">Investigation</span> of compressive membrane <span class="hlt">action</span> in ultra high performance concrete slab strips</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Foust, Bradley Wade</p> <p></p> <p>Reinforced concrete slabs are found in very common structural systems in both civilian and military applications. The boundary conditions that support the slab play an important role in the response to a particular load. Specifically, the amount of lateral and rotational restraint dictates how a slab responds to a particular load. Compressive membrane (i.e., in-plane) forces are present in slabs when the boundaries are sufficiently stiff, therefore restricting the slab from both lateral translations and rotations. Advancements have been made to account for the additional capacity due to compressive membrane forces in conventional strength concrete. In today's world, concrete performance is improving because of increasing compressive strengths and additional ductility present in concrete members. As a result of this current improvement, there is an urgent need to <span class="hlt">investigate</span> compressive membrane theory in ultra-high-performance concrete (UHPC) slabs to better understand their behavior. Existing compressive membrane theory should be revisited to determine if current theory is applicable, or if it is not, what modifications should be made. This study will provide insight into the validity of existing theory that is currently used to predict the ultimate capacity in conventional-strength concrete slabs and attempt to modify the existing equations to account for high-strength concrete materials. A matrix of 14 normal-strength concrete (NSC) and 13 UHPC slabs was tested both statically and dynamically to better understand the behavior of each material set and the effects that boundary conditions have on slab response. The results from these experiments were then compared to response calculations made from existing theory as well as finite element analyses. Valuable data sets on rigidly restrained UHPC slab response were obtained through an experimental research program. The experiments helped to validate the associated numerical analysis that was performed. It was</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19890006945','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19890006945"><span id="translatedtitle">Extending the granularity of representation and control for the MIL-STD <span class="hlt">CAIS</span> 1.0 node model</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Rogers, Kathy L.</p> <p>1986-01-01</p> <p>The Common APSE (Ada 1 Program Support Environment) Interface Set (<span class="hlt">CAIS</span>) (DoD85) node model provides an excellent baseline for interfaces in a single-host development environment. To encompass the entire spectrum of computing, however, the <span class="hlt">CAIS</span> model should be extended in four areas. It should provide the interface between the engineering workstation and the host system throughout the entire lifecycle of the system. It should provide a basis for communication and integration functions needed by distributed host environments. It should provide common interfaces for communications mechanisms to and among target processors. It should provide facilities for integration, validation, and verification of test beds extending to distributed systems on geographically separate processors with heterogeneous instruction set architectures (ISAS). Additions to the PROCESS NODE model to extend the <span class="hlt">CAIS</span> into these four areas are proposed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/9731333','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/9731333"><span id="translatedtitle">Using <span class="hlt">CAI</span> to accommodate a variety of learning styles in a biomechanics course.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Washington, N; Parnianpour, M</p> <p>1997-01-01</p> <p>Multimedia technology offers a more interactive approach to instruction than the traditional classroom lectures. Through computer-aided instruction (<span class="hlt">CAI</span>), a number of teaching styles can be used that take into account the different preferences of the students. The Biomechanics Tutorial program that the authors have written is a <span class="hlt">CAI</span> that incorporates audio, video, simulations, and graphics to: review concepts of mechanics (kinematics and kinetics of interconnected rigid bodies), familiarize students with functional anatomy, and allow students to interactively evaluate the law of mechanics applied to physical performance of activities modeled by a set of biomechanical models of the joints. Principles of ergonomics are reinforced by enabling the student to perform numerous numerical experiments within the context of workplace or task redesign and see the real time consequences of these alterations. For example, the task of holding a load is simulated by allowing the student to change elbow and shoulder angles and the orientation and magnitude of the load. The consequences of these in terms of required muscle forces and joint reaction forces at the elbow and shoulder will be updated on the screen. The detailed rationale of developing this Biomechanics Tutorial which integrates a variety of learning styles will be presented.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3910891','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3910891"><span id="translatedtitle"><span class="hlt">Investigations</span> of the Mode of <span class="hlt">Action</span> and Resistance Development of Cadazolid, a New Antibiotic for Treatment of Clostridium difficile Infections</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Caspers, Patrick; Bruyère, Thierry; Schroeder, Susanne; Pfaff, Philippe; Knezevic, Andreja; Keck, Wolfgang; Ritz, Daniel</p> <p>2014-01-01</p> <p>Cadazolid is a new oxazolidinone-type antibiotic currently in clinical development for the treatment of Clostridium difficile-associated diarrhea. Here, we report <span class="hlt">investigations</span> on the mode of <span class="hlt">action</span> and the propensity for spontaneous resistance development in C. difficile strains. Macromolecular labeling experiments indicated that cadazolid acts as a potent inhibitor of protein synthesis, while inhibition of DNA synthesis was also observed, albeit only at substantially higher concentrations of the drug. Strong inhibition of protein synthesis was also obtained in strains resistant to linezolid, in agreement with low MICs against such strains. Inhibition of protein synthesis was confirmed in coupled transcription/translation assays using extracts from different C. difficile strains, including strains resistant to linezolid, while inhibitory effects in DNA topoisomerase assays were weak or not detectable under the assay conditions. Spontaneous resistance frequencies of cadazolid were low in all strains tested (generally <10−10 at 2× to 4× the MIC), and in multiple-passage experiments (up to 13 passages) MICs did not significantly increase. Furthermore, no cross-resistance was observed, as cadazolid retained potent activity against strains resistant or nonsusceptible to linezolid, fluoroquinolones, and the new antibiotic fidaxomicin. In conclusion, the data presented here indicate that cadazolid acts primarily by inhibition of protein synthesis, with weak inhibition of DNA synthesis as a potential second mode of <span class="hlt">action</span>, and suggest a low potential for spontaneous resistance development. PMID:24277035</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24277035','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24277035"><span id="translatedtitle"><span class="hlt">Investigations</span> of the mode of <span class="hlt">action</span> and resistance development of cadazolid, a new antibiotic for treatment of Clostridium difficile infections.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Locher, Hans H; Caspers, Patrick; Bruyère, Thierry; Schroeder, Susanne; Pfaff, Philippe; Knezevic, Andreja; Keck, Wolfgang; Ritz, Daniel</p> <p>2014-01-01</p> <p>Cadazolid is a new oxazolidinone-type antibiotic currently in clinical development for the treatment of Clostridium difficile-associated diarrhea. Here, we report <span class="hlt">investigations</span> on the mode of <span class="hlt">action</span> and the propensity for spontaneous resistance development in C. difficile strains. Macromolecular labeling experiments indicated that cadazolid acts as a potent inhibitor of protein synthesis, while inhibition of DNA synthesis was also observed, albeit only at substantially higher concentrations of the drug. Strong inhibition of protein synthesis was also obtained in strains resistant to linezolid, in agreement with low MICs against such strains. Inhibition of protein synthesis was confirmed in coupled transcription/translation assays using extracts from different C. difficile strains, including strains resistant to linezolid, while inhibitory effects in DNA topoisomerase assays were weak or not detectable under the assay conditions. Spontaneous resistance frequencies of cadazolid were low in all strains tested (generally <10(-10) at 2× to 4× the MIC), and in multiple-passage experiments (up to 13 passages) MICs did not significantly increase. Furthermore, no cross-resistance was observed, as cadazolid retained potent activity against strains resistant or nonsusceptible to linezolid, fluoroquinolones, and the new antibiotic fidaxomicin. In conclusion, the data presented here indicate that cadazolid acts primarily by inhibition of protein synthesis, with weak inhibition of DNA synthesis as a potential second mode of <span class="hlt">action</span>, and suggest a low potential for spontaneous resistance development.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19595988','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19595988"><span id="translatedtitle">Disruption of Saccharomyces cerevisiae by Plantaricin 149 and <span class="hlt">investigation</span> of its mechanism of <span class="hlt">action</span> with biomembrane model systems.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lopes, José Luiz S; Nobre, Thatyane M; Siano, Alvaro; Humpola, Verónica; Bossolan, Nelma R S; Zaniquelli, Maria E D; Tonarelli, Georgina; Beltramini, Leila M</p> <p>2009-10-01</p> <p>The <span class="hlt">action</span> of a synthetic antimicrobial peptide analog of Plantaricin 149 (Pln149a) against Saccharomyces cerevisiae and its interaction with biomembrane model systems were <span class="hlt">investigated</span>. Pln149a was shown to inhibit S. cerevisiae growth by more than 80% in YPD medium, causing morphological changes in the yeast wall and remaining active and resistant to the yeast proteases even after 24 h of incubation. Different membrane model systems and carbohydrates were employed to better describe the Pln149a interaction with cellular components using circular dichroism and fluorescence spectroscopies, adsorption kinetics and surface elasticity in Langmuir monolayers. These assays showed that Pln149a does not interact with either mono/polysaccharides or zwitterionic LUVs, but is strongly adsorbed to and incorporated into negatively charged surfaces, causing a conformational change in its secondary structure from random-coil to helix upon adsorption. From the concurrent analysis of Pln149a adsorption kinetics and dilatational surface elasticity data, we determined that 2.5 muM is the critical concentration at which Pln149a will disrupt a negative DPPG monolayer. Furthermore, Pln149a exhibited a carpet-like mechanism of <span class="hlt">action</span>, in which the peptide initially binds to the membrane, covering its surface and acquiring a helical structure that remains associated to the negatively charged phospholipids. After this electrostatic interaction, another peptide region causes a strain in the membrane, promoting its disruption.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20120001852','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20120001852"><span id="translatedtitle">Ca-Fe and Alkali-Halide Alteration of an Allende Type B <span class="hlt">CAI</span>: Aqueous Alteration in Nebular or Asteroidal Settings</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Ross, D. K.; Simon, J. I.; Simon, S. B.; Grossman, L.</p> <p>2012-01-01</p> <p>Ca-Fe and alkali-halide alteration of <span class="hlt">CAIs</span> is often attributed to aqueous alteration by fluids circulating on asteroidal parent bodies after the various chondritic components have been assembled, although debate continues about the roles of asteroidal vs. nebular modification processes [1-7]. Here we report de-tailed observations of alteration products in a large Type B2 <span class="hlt">CAI</span>, TS4 from Allende, one of the oxidized subgroup of CV3s, and propose a speculative model for aqueous alteration of <span class="hlt">CAIs</span> in a nebular setting. Ca-Fe alteration in this <span class="hlt">CAI</span> consists predominantly of end-member hedenbergite, end-member andradite, and compositionally variable, magnesian high-Ca pyroxene. These phases are strongly concentrated in an unusual "nodule" enclosed within the interior of the <span class="hlt">CAI</span> (Fig. 1). The Ca, Fe-rich nodule superficially resembles a clast that pre-dated and was engulfed by the <span class="hlt">CAI</span>, but closer inspection shows that relic spinel grains are enclosed in the nodule, and corroded <span class="hlt">CAI</span> primary phases interfinger with the Fe-rich phases at the nodule s margins. This <span class="hlt">CAI</span> also contains abundant sodalite and nepheline (alkali-halide) alteration that occurs around the rims of the <span class="hlt">CAI</span>, but also penetrates more deeply into the <span class="hlt">CAI</span>. The two types of alteration (Ca-Fe and alkali-halide) are adjacent, and very fine-grained Fe-rich phases are associated with sodalite-rich regions. Both types of alteration appear to be replacive; if that is true, it would require substantial introduction of Fe, and transport of elements (Ti, Al and Mg) out of the nodule, and introduction of Na and Cl into alkali-halide rich zones. Parts of the <span class="hlt">CAI</span> have been extensively metasomatized.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20140010679','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20140010679"><span id="translatedtitle">Microstructures of Hibonite From an ALH A77307 (CO3.0) <span class="hlt">CAI</span>: Evidence for Evaporative Loss of Calcium</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Han, Jangmi; Brearley, Adrian J.; Keller, Lindsay P.</p> <p>2014-01-01</p> <p>Hibonite is a comparatively rare, primary phase found in some <span class="hlt">CAIs</span> from different chondrite groups and is also common in Wark-Lovering rims [1]. Hibonite is predicted to be one of the earliest refractory phases to form by equilibrium condensation from a cooling gas of solar composition [2] and, therefore, can be a potential recorder of very early solar system processes. In this study, we describe the microstructures of hibonite from one <span class="hlt">CAI</span> in ALH A77307 (CO3.0) using FIB/TEM techniques in order to reconstruct its formational history.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20160002651','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20160002651"><span id="translatedtitle">Calcium and Titanium Isotope Fractionation in <span class="hlt">CAIS</span>: Tracers of Condensation and Inheritance in the Early Solar Protoplanetary Disk</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Simon, J. I.; Jordan, M. K.; Tappa, M. J.; Kohl, I. E.; Young, E. D.</p> <p>2016-01-01</p> <p>The chemical and isotopic compositions of calcium-aluminum-rich inclusions (<span class="hlt">CAIs</span>) can be used to understand the conditions present in the protoplantary disk where they formed. The isotopic compositions of these early-formed nebular materials are largely controlled by chemical volatility. The isotopic effects of evaporation/sublimation, which are well explained by both theory and experimental work, lead to enrichments of the heavy isotopes that are often exhibited by the moderately refractory elements Mg and Si. Less well understood are the isotopic effects of condensation, which limits our ability to determine whether a <span class="hlt">CAI</span> is a primary condensate and/or retains any evidence of its primordial formation history.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED503459.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED503459.pdf"><span id="translatedtitle">A Comparative Study to Evaluate the Effectiveness of Computer Assisted Instruction (<span class="hlt">CAI</span>) versus Class Room Lecture (RL) for Computer Science at ICS Level</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Kausar, Tayyaba; Choudhry, Bushra Naoreen; Gujjar, Aijaz Ahmed</p> <p>2008-01-01</p> <p>This study was aimed to evaluate the effectiveness of <span class="hlt">CAI</span> vs. classroom lecture for computer science at ICS level. The objectives were to compare the learning effects of two groups with class room lecture and computer assisted instruction studying the same curriculum and the effects of <span class="hlt">CAI</span> and CRL in terms of cognitive development. Hypothesis of…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/EJ1102933.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/EJ1102933.pdf"><span id="translatedtitle">A Comparative Study to Evaluate the Effectiveness of Computer Assisted Instruction (<span class="hlt">CAI</span>) versus Class Room Lecture (CRL) for Computer Science at ICS Level</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Kausar, Tayyaba; Choudhry, Bushra Naoreen; Gujjar, Aijaz Ahmed</p> <p>2008-01-01</p> <p>This study was aimed to evaluate the effectiveness of <span class="hlt">CAI</span> vs. classroom lecture for computer science at ICS level. The objectives were to compare the learning effects of two groups with class room lecture and computer assisted instruction studying the same curriculum and the effects of <span class="hlt">CAI</span> and CRL in terms of cognitive development. Hypothesis of…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016AmJPh..84..704M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016AmJPh..84..704M"><span id="translatedtitle"><span class="hlt">Action</span> physics</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>McGinness, Lachlan P.; Savage, C. M.</p> <p>2016-09-01</p> <p>More than a decade ago, Edwin Taylor issued a "call to <span class="hlt">action</span>" that presented the case for basing introductory university mechanics teaching around the principle of stationary <span class="hlt">action</span> [E. F. Taylor, Am. J. Phys. 71, 423-425 (2003)]. We report on our response to that call in the form of an <span class="hlt">investigation</span> of the teaching and learning of the stationary <span class="hlt">action</span> formulation of physics in a first-year university course. Our <span class="hlt">action</span> physics instruction proceeded from the many-paths approach to quantum physics to ray optics, classical mechanics, and relativity. Despite the challenges presented by <span class="hlt">action</span> physics, students reported it to be accessible, interesting, motivational, and valuable.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/760747','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/760747"><span id="translatedtitle">Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan for Corrective <span class="hlt">Action</span> Unit 254: Area 25 R-MAD Decontamination Facility, Nevada Test Site, Nevada (includes ROTC No. 1, date 01/25/1999)</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>DOE /NV</p> <p>1999-07-29</p> <p>This Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan contains the US Department of Energy, Nevada Operations Office's approach to collect the data necessary to evaluate corrective <span class="hlt">action</span> alternatives appropriate for the closure of Corrective <span class="hlt">Action</span> Unit (CAU) 254 under the Federal Facility Agreement and Consent Order. Corrective <span class="hlt">Action</span> Unit 254 consists of Corrective <span class="hlt">Action</span> Site (CAS) 25-23-06, Decontamination Facility. Located in Area 25 at the Nevada Test Site (NTS), CAU 254 was used between 1963 through 1973 for the decontamination of test-car hardware and tooling used in the Nuclear Rocket Development Station program. The CAS is composed of a fenced area measuring approximately 119 feet by 158 feet that includes Building 3126, an associated aboveground storage tank, a potential underground storage area, two concrete decontamination pads, a generator, two sumps, and a storage yard. Based on site history, the scope of this plan is to resolve the problem statement identified during the Data Quality Objectives process that decontamination activities at this CAU site may have resulted in the release of contaminants of concern (COCs) onto building surfaces, down building drains to associated leachfields, and to soils associated with two concrete decontamination pads located outside the building. Therefore, the scope of the corrective <span class="hlt">action</span> field <span class="hlt">investigation</span> will involve soil sampling at biased and random locations in the yard using a direct-push method, scanning and static radiological surveys, and laboratory analyses of all soil/building samples. Historical information provided by former NTS employees indicates that solvents and degreasers may have been used in the decontamination processes; therefore, potential COCs include volatile/semivolatile organic compounds, Resource Conservation and Recovery Act metals, petroleum hydrocarbons, polychlorinated biphenyls, pesticides, asbestos, gamma-emitting radionuclides, plutonium, uranium, and strontium-90. The results of this</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/812379','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/812379"><span id="translatedtitle">Corrective <span class="hlt">Action</span> Decision Document for Corrective <span class="hlt">Action</span> Unit 271: Areas 25, 26, and 27 Septic Systems, Nevada Test Site, Nevada, Rev. 0</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>NNSA /NV</p> <p>2002-09-16</p> <p>This corrective <span class="hlt">action</span> decision document (CADD) identifies and rationalizes the U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office's selection of a recommended corrective <span class="hlt">action</span> alternative (CAA) appropriate to facilitate the closure of Corrective <span class="hlt">Action</span> Unit (CAU) 271, Areas 25, 26, and 27 Septic Systems, Nevada Test Site (NTS), Nevada, under the Federal Facility Agreement and Consent Order (FFACO). Located on the NTS approximately 65 miles northwest of Las Vegas, CAU 271 consists of fifteen Corrective <span class="hlt">Action</span> Sites (CASs). The CASs consist of 13 septic systems, a radioactive leachfield, and a contaminated reservoir. The purpose of this CADD is to identify and provide a rationale for the selection of a recommended CAA for each CAS within CAU 271. Corrective <span class="hlt">action</span> <span class="hlt">investigation</span> (<span class="hlt">CAI</span>) activities were performed from October 29, 2001, through February 22, 2002, and April 29, 2002, through June 25, 2002. Analytes detected during the <span class="hlt">CAI</span> were evaluated against preliminary <span class="hlt">action</span> levels and regulatory disposal limits to determine contaminants of concern (COC) for each CAS. It was determined that contaminants of concern included hydrocarbon-contaminated media, polychlorinated biphenyls, and radiologically-contaminated media. Three corrective <span class="hlt">action</span> objectives were identified for these CASs, and subsequently three CAAs developed for consideration based on a review of existing data, future use, and current operations in Areas 25, 26, and 27 of the NTS. These CAAs were: Alternative 1 - No Further <span class="hlt">Action</span>, Alternative 2 - Clean Closure, and Alternative 3 - Closure in Place with Administrative Controls. Alternative 2, Clean Closure, was chosen as the preferred CAA for all but two of the CASs (25-04-04 and 27-05-02) because Nevada Administrative Control 444.818 requires clean closure of the septic tanks involved with these CASs. Alternative 3, Closure in Place, was chosen for the final two CASs because the short-term risks of</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/1063902','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/1063902"><span id="translatedtitle">Corrective <span class="hlt">Action</span> Decision Document/Closure Report for Corrective <span class="hlt">Action</span> Unit 504: 16a-Tunnel Muckpile, Nevada Test Site</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>NSTec Environmental Restoration</p> <p>2010-03-15</p> <p>This Corrective <span class="hlt">Action</span> Decision Document (CADD)/Closure Report (CR) was prepared by the Defense Threat Reduction Agency (DTRA) for Corrective <span class="hlt">Action</span> Unit (CAU) 504, 16a-Tunnel Muckpile. This CADD/CR is consistent with the requirements of the Federal Facility Agreement and Consent Order (FFACO) agreed to by the State of Nevada; U.S. Department of Energy (DOE), Environmental Management; U.S. Department of Defense; and DOE, Legacy Management. Corrective <span class="hlt">Action</span> Unit 504 is comprised of four Corrective <span class="hlt">Action</span> Sites (CASs): • 16-06-01, Muckpile • 16-23-01, Contaminated Burial Pit • 16-23-02, Contaminated Area • 16-99-01, Concrete Construction Waste Corrective <span class="hlt">Action</span> Site 16-23-01 is not a burial pit; it is part of CAS 16-06-01. Therefore, there is not a separate data analysis and assessment for CAS 16-23-01; it is included as part of the assessment for CAS 16-06-01. In addition to these CASs, the channel between CAS 16-23-02 (Contaminated Area) and Mid Valley Road was <span class="hlt">investigated</span> with walk-over radiological surveys and soil sampling using hand tools. The purpose of this CADD/CR is to provide justification and documentation supporting the recommendation for closure in place with use restrictions for CAU 504. A CADD was originally submitted for CAU 504 and approved by the Nevada Division of Environmental Protection (NDEP). However, following an agreement between NDEP, DTRA, and the DOE, National Nuclear Security Administration Nevada Site Office to change to a risk-based approach for assessing the corrective <span class="hlt">action</span> <span class="hlt">investigation</span> (<span class="hlt">CAI</span>) data, NDEP agreed that the CAU could be re-evaluated using the risk-based approach and a CADD/CR prepared to close the site.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED094732.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED094732.pdf"><span id="translatedtitle">Individual Differences and Learner Control I: Program Development and <span class="hlt">Investigation</span> of Control Over Mnemonics in Computer-Assisted Instruction. AFHRL-TR-74-3. Interim Report.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Judd, Wilson A.; And Others</p> <p></p> <p>The reported research was designed to <span class="hlt">investigate</span> the impact of learner control on performance and anxiety in a computer-assisted instruction (<span class="hlt">CAI</span>) task. The first phase entailed the development of a two-hour <span class="hlt">CAI</span> program on the identification of edible plants. The second phase was experimentation to determine the effectiveness of learner control.…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/939196','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/939196"><span id="translatedtitle">Corrective <span class="hlt">Action</span> Decision Document/ Closure Report for Corrective <span class="hlt">Action</span> Unit 556: Dry Wells and Surface Release Points, Nevada Test Site, Nevada with Errata Sheet, Revision 0</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Grant Evenson</p> <p>2008-09-01</p> <p>This Corrective <span class="hlt">Action</span> Decision Document (CADD)/Closure Report (CR) has been prepared for Corrective <span class="hlt">Action</span> Unit 556, Dry Wells and Surface Release Points, located at the Nevada Test Site, Nevada, in accordance with the Federal Facility Agreement and Consent Order (FFACO, 1996; as amended February 2008). Corrective <span class="hlt">Action</span> Unit (CAU) 556 is comprised of four corrective <span class="hlt">action</span> sites (CASs): • 06-20-04, National Cementers Dry Well • 06-99-09, Birdwell Test Hole • 25-60-03, E-MAD Stormwater Discharge and Piping • 25-64-01, Vehicle Washdown and Drainage Pit The purpose of this CADD/CR is to provide justification and documentation supporting the recommendation for closure of CAU 556 with no further corrective <span class="hlt">action</span>. To achieve this, corrective <span class="hlt">action</span> <span class="hlt">investigation</span> (<span class="hlt">CAI</span>) activities began on February 7 and were completed on June 19, 2008, as set forth in the Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan for Corrective <span class="hlt">Action</span> Unit 556: Dry Wells and Surface Release Points, Nevada Test Site, Nevada (NNSA/NSO, 2007). The purpose of the <span class="hlt">CAI</span> was to fulfill the following data needs as defined during the data quality objective (DQO) process: • Determine whether contaminants of concern (COCs) are present. • If COCs are present, determine their nature and extent. • Provide sufficient information and data to complete appropriate corrective <span class="hlt">actions</span>. The CAU 556 data were evaluated based on the data quality assessment process, which demonstrated the quality and acceptability of the data for use in fulfilling the DQO data needs. Analytes detected during the <span class="hlt">CAI</span> were evaluated against appropriate final <span class="hlt">action</span> levels (FALs) to identify the COCs for each CAS. The results of the <span class="hlt">CAI</span> identified COCs at one of the four CASs in CAU 556 that required the completion of a corrective <span class="hlt">action</span>. Assessment of the data generated from <span class="hlt">investigation</span> activities conducted at CAU 556 revealed the following: • Corrective <span class="hlt">Action</span> Sites 06-20-04, 06-99-09, and 25-64-01 do not contain contamination at</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016DPS....4850505D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016DPS....4850505D"><span id="translatedtitle">Linking <span class="hlt">CAI</span> abundance to polarimetric response in a population of ancient asteroids</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Devogele, Maxime; Tanga, Paolo; Bendjoya, Philippe; Rivet, Jean-Pierre; Surdej, Jean; Bus, Schelte J.; Sunshine, Jessica M.; Cellino, Alberto; Campins, Humberto; Licandro, Javier; Pinilla-Alonso, Noemi; Carry, Benoit</p> <p>2016-10-01</p> <p>Polarimetry constitutes one of the fundamental tools for characterizing the surface texture and composition of airless Solar System bodies. In 2006, polarimetric observations led to the discovery of a new type of asteroids, which displays a peculiar polarimetric response. These asteroids are collectively known as "Barbarians", from (234) Barbara the first discovered one.The most commonly accepted explanation for this perculiar polarization response seems to be the presence of a high percentage of fluffy-type Calcium Aluminium-rich Inclusions (<span class="hlt">CAIs</span>), whose optical properties could produce the observed polarization. Their reflectance spectra also exibit an absorption feature in the near-infrared around 2.1-2.2 microns, that is characteristic of this peculiar group.Based on these results, we organized a systematic polarimetric and near-infrared observational campaign of known Barbarians or candidate asteroids. These campaigns include members of the family of 1040 Klumpkea, 2085 Henan and 729 Watsonia, which are known to contain Barbarian and/or L-type asteroids also suspected to have such a polarimetric behaviour. We have made use of the ToPo polarimeter at the 1m telescope of the Centre pédagogique Planète et Univers (C2PU, Observatoire de la Côte d'Azur, France). The spectroscopic observations in the near-infrared were obtained with the SpeX instrument at the NASA's InfraRed Telescope Facility (IRTF).By combining polarimetry and spectroscopy we find a correlation between the abundance of <span class="hlt">CAIs</span> and the inversion angle of the phase-polarization curve of Barbarian asteroids. This is the first time that a direct link has been established between a specific polarimetric response and the surface composition of asteroids. In addition, we find a considerable variety of <span class="hlt">CAI</span> abundance from one object to the other, consistent with a wide range of possible albedos. Since these asteroids constitute a reservoir of primitive Solar System material, understanding their origin can</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/841679','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/841679"><span id="translatedtitle">Experimental <span class="hlt">Investigation</span> of the Root Cause Mechanism and Effectiveness of Mitigating <span class="hlt">Actions</span> for Axial Offset Anomaly in Pressurized Water Reactors</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Said Abdel-Khalik</p> <p>2005-07-02</p> <p>Axial offset anomaly (AOA) in pressurized water reactors refers to the presence of a significantly larger measured negative axial offset deviation than predicted by core design calculations. The neutron flux depression in the upper half of high-power rods experiencing significant subcooled boiling is believed to be caused by the concentration of boron species within the crud layer formed on the cladding surface. Recent <span class="hlt">investigations</span> of the root-cause mechanism for AOA [1,2] suggest that boron build-up on the fuel is caused by precipitation of lithium metaborate (LiBO2) within the crud in regions of subcooled boiling. Indirect evidence in support of this hypothesis was inferred from operating experience at Callaway, where lithium return and hide-out were, respectively, observed following power reductions and power increases when AOA was present. However, direct evidence of lithium metaborate precipitation within the crud has, heretofore, not been shown because of its retrograde solubility. To this end, this <span class="hlt">investigation</span> has been undertaken in order to directly verify or refute the proposed root-cause mechanism of AOA, and examine the effectiveness of possible mitigating <span class="hlt">actions</span> to limit its impact in high power PWR cores.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3514444','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3514444"><span id="translatedtitle">EXPERIMENTAL STRATEGIES FOR <span class="hlt">INVESTIGATING</span> PSYCHOSTIMULANT DRUG <span class="hlt">ACTIONS</span> AND PREFRONTAL CORTICAL FUNCTON IN ADHD AND RELATED ATTENTION DISORDERS</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Agster, K. L.; Clark, B. D.; Gao, W-J.; Shumsky, J. S.; Wang, H-X.; Berridge, C. W.; Waterhouse, B. D.</p> <p>2011-01-01</p> <p>Amphetamine-like psychostimulant drugs have been used for decades to treat a variety of clinical conditions. Methylphenidate (MPH) - RitalinR, a compound that blocks reuptake of synaptically released norepinephrine (NE) and dopamine (DA) in the brain, has been used for more than 30 years in low dose, long-term regimens to treat attention deficit-hyperactive disorder (ADHD) in juveniles, adolescents, and adults. These agents are now also becoming increasingly popular among healthy individuals from all walks of life (e.g. military, students) and age groups (teenagers thru senior citizens) to promote wakefulness and improve attention. While there is agreement regarding the primary biochemical <span class="hlt">action</span> of MPH, the physiological basis for its efficacy in normal individuals and ADHD patients is lacking. Study of the behavioral and physiological <span class="hlt">actions</span> of clinically and behaviorally relevant doses of MPH in normal animals provides an opportunity to explore the role of catecholamine transmitters in prefrontal cortical function and attentional processes as they relate to normal operation of brain circuits and ADHD pathology. The goal of ongoing studies has been to: 1) assess the effects of low dose MPH on rodent performance in a well characterized sensory-guided sustained attention task, 2) examine the effects of the same low-dose chronic MPH administration on task-related discharge of prefrontal cortical (PFC) neurons and 3) <span class="hlt">investigate</span> the effects of NE and DA on membrane response properties and synaptic transmission in identified subsets of PFC neurons. Combinations of these approaches can be used in adolescent, adult and aged animals to identify the parameters of cell and neural circuit function that are regulated by MPH and to establish an overarching explanation of how MPH impacts PFC operations from cellular through behavioral functional domains. PMID:21901844</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active"><span>19</span></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_19 --> <div id="page_20" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="381"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=csr&pg=2&id=EJ1062828','ERIC'); return false;" href="http://eric.ed.gov/?q=csr&pg=2&id=EJ1062828"><span id="translatedtitle">From Corporate Social Responsibility, through Entrepreneurial Orientation, to Knowledge Sharing: A Study in <span class="hlt">Cai</span> Luong (Renovated Theatre) Theatre Companies</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Tuan, Luu Trong</p> <p>2015-01-01</p> <p>Purpose: This paper aims to examine the role of antecedents such as corporate social responsibility (CSR) and entrepreneurial orientation in the chain effect to knowledge sharing among members of <span class="hlt">Cai</span> Luong theatre companies in the Vietnamese context. Knowledge sharing contributes to the depth of the knowledge pool of both the individuals and the…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED077195.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED077195.pdf"><span id="translatedtitle">A Model Driven Question-Answering System for a <span class="hlt">CAI</span> Environment. Final Report (July 1970 to May 1972).</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Brown, John S.; And Others</p> <p></p> <p>A question answering system which permits a computer-assisted instruction (<span class="hlt">CAI</span>) student greater initiative in the variety of questions he can ask is described. A method is presented to represent the dynamic processes of a subject matter area by augmented finite state automata, which permits efficient inferencing about dynamic processes and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26832141','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26832141"><span id="translatedtitle">Phenotypic diversity and correlation between white-opaque switching and the <span class="hlt">CAI</span> microsatellite locus in Candida albicans.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hu, Jian; Guan, Guobo; Dai, Yu; Tao, Li; Zhang, Jianzhong; Li, Houmin; Huang, Guanghua</p> <p>2016-08-01</p> <p>Candida albicans is a commensal fungal pathogen that is often found as part of the human microbial flora. The aim of the present study was to establish a relationship between diverse genotypes and phenotypes of clinical isolates of C. albicans. Totally 231 clinical isolates were collected and used for genotyping and phenotypic switching analysis. Based on the microsatellite locus (<span class="hlt">CAI</span>) genotyping assay, 65 different genotypes were identified, and some dominant types were found in certain human niches. For example, the genotypes of 30-44 and 30-45 were enriched in vaginal infection samples. C. albicans has a number of morphological forms including the single-celled yeasts, multicellular filaments, white, and opaque cell types. The relationship between the <span class="hlt">CAI</span> genotype and the ability to undergo phenotypic switching was examined in the clinical isolates. We found that the strains with longer CAA/G repeats in both alleles of the <span class="hlt">CAI</span> locus were more opaque competent. We also discovered that some MTL heterozygous (a/alpha) isolates could undergo white-opaque switching when grown on regular culture medium (containing glucose as the sole carbon source). Our study establishes a link between phenotypic switching and genotypes of the <span class="hlt">CAI</span> microsatellite locus in clinical isolates of C. albicans. PMID:26832141</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2784433','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2784433"><span id="translatedtitle">Hunting and use of terrestrial fauna used by <span class="hlt">Cai</span>çaras from the Atlantic Forest coast (Brazil)</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2009-01-01</p> <p>Background The Brazilian Atlantic Forest is considered one of the hotspots for conservation, comprising remnants of rain forest along the eastern Brazilian coast. Its native inhabitants in the Southeastern coast include the <span class="hlt">Cai</span>çaras (descendants from Amerindians and European colonizers), with a deep knowledge on the natural resources used for their livelihood. Methods We studied the use of the terrestrial fauna in three <span class="hlt">Cai</span>çara communities, through open-ended interviews with 116 native residents. Data were checked through systematic observations and collection of zoological material. Results The dependence on the terrestrial fauna by <span class="hlt">Cai</span>çaras is especially for food and medicine. The main species used are Didelphis spp., Dasyprocta azarae, Dasypus novemcinctus, and small birds (several species of Turdidae). Contrasting with a high dependency on terrestrial fauna resources by native Amazonians, the <span class="hlt">Cai</span>çaras do not show a constant dependency on these resources. Nevertheless, the occasional hunting of native animals represents a complimentary source of animal protein. Conclusion Indigenous or local knowledge on native resources is important in order to promote local development in a sustainable way, and can help to conserve biodiversity, particularly if the resource is sporadically used and not commercially exploited. PMID:19930595</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26159472','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26159472"><span id="translatedtitle">Changes in flavour and microbial diversity during natural fermentation of suan-<span class="hlt">cai</span>, a traditional food made in Northeast China.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wu, Rina; Yu, Meiling; Liu, Xiaoyu; Meng, Lingshuai; Wang, Qianqian; Xue, Yating; Wu, Junrui; Yue, Xiqing</p> <p>2015-10-15</p> <p>We measured changes in the main physical and chemical properties, flavour compounds and microbial diversity in suan-<span class="hlt">cai</span> during natural fermentation. The results showed that the pH and concentration of soluble protein initially decreased but were then maintained at a stable level; the concentration of nitrite increased in the initial fermentation stage and after reaching a peak it decreased significantly to a low level by the end of fermentation. Suan-<span class="hlt">cai</span> was rich in 17 free amino acids. All of the free amino acids increased in concentration to different degrees, except histidine. Total free amino acids reached their highest levels in the mid-fermentation stage. The 17 volatile flavour components identified at the start of fermentation increased to 57 by the mid-fermentation stage; esters and aldehydes were in the greatest diversity and abundance, contributing most to the aroma of suan-<span class="hlt">cai</span>. Bacteria were more abundant and diverse than fungi in suan-<span class="hlt">cai</span>; 14 bacterial species were identified from the genera Leuconostoc, Bacillus, Pseudomonas and Lactobacillus. The predominant fungal species identified were Debaryomyces hansenii, Candida tropicalis and Penicillium expansum.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20140010652','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20140010652"><span id="translatedtitle">A FIB/TEM/Nanosims Study of a Wark-Lovering Rim on an Allende <span class="hlt">CAI</span></span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Keller, L. P.; Needham, A. W.; Messenger, S.</p> <p>2014-01-01</p> <p>Ca- Al-rich inclusions (<span class="hlt">CAIs</span>) are commonly surrounded by Wark-Lovering (WL) rims - thin (approx. 50 micrometers) multilayered sequences - whose mineralogy is dominated by high temperature minerals similar to those that occur in the cores of <span class="hlt">CAIs</span> [1]. The origins of these WL rims involved high temperature events in the early nebula such as condensation, flashheating or reaction with a nebular reservoir, or combinations of these processes. These rims formed after <span class="hlt">CAI</span> formation but prior to accretion into their parent bodies. We have undertaken a coordinated mineralogical and isotopic study of WL rims to determine the formation conditions of the individual layers and to constrain the isotopic reservoirs they interacted with during their history. We focus here on the spinel layer, the first-formed highest- temperature layer in the WL rim sequence. Results and Discussion: We have performed mineralogical, chemical and isotopic analyses of an unusual ultrarefractory inclusion from the Allende CV3 chondrite (SHAL) consisting of an approx. 500 micrometers long single crystal of hibonite and co-existing coarsegrained perovskite. SHAL is partially surrounded by WL rim. We previously reported on the mineralogy, isotopic compositions and trace elements in SHAL [2-4]. The spinel layer in the WL rim is present only on the hibonite and terminates abruptly at the contact with the coarse perovskite. This simple observation shows that the spinel layer is not a condensate in this case (otherwise spinel would have condensed on the perovskite as well). The spinel layer appears to have formed by gas-phase corrosion of the hibonite by Mg-rich vapors such that the spinel layer grew at the expense of the hibonite. We also found that the spinel layer has the same 16Orich composition as the hibonite. The spinel layer is polycrystalline and individual crystals do not show a crystallographic relationship with the hibonite. An Al-diopside layer overlies the spinel layer, and is present on both</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015NIMPB.361...69R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015NIMPB.361...69R"><span id="translatedtitle">Two years since SSAMS: Status of 14C AMS at <span class="hlt">CAIS</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ravi Prasad, G. V.; Cherkinsky, Alexander; Culp, Randy A.; Dvoracek, Doug K.</p> <p>2015-10-01</p> <p>The NEC 250 kV single stage AMS accelerator (SSAMS) was installed two years ago at the Center for Applied Isotope Studies (<span class="hlt">CAIS</span>), University of Georgia. The accelerator is primarily being used for radiocarbon measurements to test the authenticity of natural and bio-based samples while all other samples such as geological, atmospheric, marine and archaeological. are run on the 500 kV, NEC 1.5SDH-1 model tandem accelerator, which has been operating since 2001. The data obtained over a six months period for OXI, OXII, ANU sucrose and FIRI-D are discussed. The mean value of ANU sucrose observed to be slightly lower than the consensus value. The processed blanks on SSAMS produce lower apparent age compared to the tandem accelerator as expected.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/817148','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/817148"><span id="translatedtitle">Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan for Corrective <span class="hlt">Action</span> Unit 214: Bunkers and Storage Areas Nevada Test Site, Nevada: Revision 0, Including Record of Technical Change No. 1 and No. 2</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office</p> <p>2003-05-16</p> <p>This Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan contains the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office's approach to collect the data necessary to evaluate corrective <span class="hlt">action</span> alternatives appropriate for the closure of Corrective <span class="hlt">Action</span> Unit (CAU) 214 under the Federal Facility Agreement and Consent Order. Located in Areas 5, 11, and 25 of the Nevada Test Site, CAU 214 consists of nine Corrective <span class="hlt">Action</span> Sites (CASs): 05-99-01, Fallout Shelters; 11-22-03, Drum; 25-99-12, Fly Ash Storage; 25-23-01, Contaminated Materials; 25-23-19, Radioactive Material Storage; 25-99-18, Storage Area; 25-34-03, Motor Dr/Gr Assembly (Bunker); 25-34-04, Motor Dr/Gr Assembly (Bunker); and 25-34-05, Motor Dr/Gr Assembly (Bunker). These sites are being <span class="hlt">investigated</span> because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective <span class="hlt">action</span> alternatives (CAAs). The suspected contaminants and critical analyte s for CAU 214 include oil (total petroleum hydrocarbons-diesel-range organics [TPH-DRO], polychlorinated biphenyls [PCBs]), pesticides (chlordane, heptachlor, 4,4-DDT), barium, cadmium, chronium, lubricants (TPH-DRO, TPH-gasoline-range organics [GRO]), and fly ash (arsenic). The land-use zones where CAU 214 CASs are located dictate that future land uses will be limited to nonresidential (i.e., industrial) activities. The results of this field <span class="hlt">investigation</span> will support a defensible evaluation of viable corrective <span class="hlt">action</span> alternatives that will be presented in the corrective <span class="hlt">action</span> decision document.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012E%26PSL.329...51S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012E%26PSL.329...51S"><span id="translatedtitle">Lithium isotope compositions of chondrules, <span class="hlt">CAI</span> and a dark inclusion from Allende and ordinary chondrites</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Seitz, Hans-Michael; Zipfel, Jutta; Brey, Gerhard P.; Ott, Ulrich</p> <p>2012-05-01</p> <p>Bulk carbonaceous and ordinary chondrites have distinct Li isotope compositions, indicating the existence of local reservoirs and distinct formation conditions in the early solar system. These differences may be also recorded in the components that compose chondrites. Here, Li concentrations and Li isotope compositions of 89 chondrules, 10 <span class="hlt">CAI</span> and 1 dark inclusion (DI) from the Allende (CV3) meteorite and from 5 ordinary chondrites of low petrologic types Semarkona, Bishunpur, Saratov, Bjurböle and Bremervörde are presented. In general, chondrules have highly variable Li isotope compositions, ranging from δ7Li of - 8.5 to + 10‰, whereby the mean isotope composition of chondrules separated from a single chondrite is slightly lighter than its bulk. Remarkable, however, are the differences in Li concentrations between bulk chondrite and chondrules. Of the entire set studied here, 98% of the chondrules have significantly lower Li abundances (in the range of 0.2 to 0.75 μg/g) than their hosts (typically around 1.5 μg/g). Our results indicate that Li elemental and isotopic fractionation has not occurred extensively during chondrule formation. Low, but highly variable Li abundances as well as the relatively large range in Li isotopes point to small-scale heterogeneities in the chondrule-forming reservoir. With respect to Li, such a non-chondritic reservoir is unique to all chondrules. The compositional differences in Li isotopes between bulk carbonaceous and ordinary chondrites (Seitz et al., 2007) are likely to be the result of mixing chondrules, <span class="hlt">CAI</span> and matrix in different proportions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/969477','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/969477"><span id="translatedtitle">Corrective <span class="hlt">Action</span> Decision Document/Closure Report for Corrective <span class="hlt">Action</span> Unit 482: Area 15 U15a/e Muckpiles and Ponds Nevada Test Site</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>NSTec Environmental Restoration</p> <p>2009-09-30</p> <p>This Corrective <span class="hlt">Action</span> Decision Document /Closure Report (CADD/CR) was prepared by the Defense Threat Reduction Agency (DTRA) for Corrective <span class="hlt">Action</span> Unit (CAU) 482 U15a/e Muckpiles and Ponds. This CADD/CR is consistent with the requirements of the Federal Facility Agreement and Consent Order agreed to by the State of Nevada, the U.S. Department of Energy, and the U.S. Department of Defense. Corrective <span class="hlt">Action</span> Unit 482 is comprised of three Corrective <span class="hlt">Action</span> Sites (CASs) and one adjacent area: CAS 15-06-01, U15e Muckpile; CAS 15-06-02, U15a Muckpile; CAS 15-38-01, Area 15 U15a/e Ponds; and Drainage below the U15a Muckpile. The purpose of this CADD/CR is to provide justification and documentation supporting the recommendation for closure with no further corrective <span class="hlt">action</span>, by placing use restrictions on the three CASs and the adjacent area of CAU 482. To support this recommendation, a corrective <span class="hlt">action</span> <span class="hlt">investigation</span> (<span class="hlt">CAI</span>) was performed in September 2002. The purpose of the <span class="hlt">CAI</span> was to fulfill the following data needs as defined during the Data Quality Objective (DQO) process: (1) Determine whether contaminants of concern (COCs) are present. (2) If COCs are present, determine their nature and extent. (3) Provide sufficient information and data to determine appropriate corrective <span class="hlt">actions</span>. The CAU 482 dataset from the <span class="hlt">CAI</span> was evaluated based on the data quality indicator parameters. This evaluation demonstrated the quality and acceptability of the dataset for use in fulfilling the DQO data needs. Analytes detected during the <span class="hlt">CAI</span> were evaluated against final <span class="hlt">action</span> levels (FALs) established in this document. Tier 2 FALS were determined for the hazardous constituents of total petroleum hydrocarbons (TPH)-diesel-range organics (DRO) and the radionuclides americium (Am)-241, cesium (Cs)-137, plutonium (Pu)-238, and Pu-239. The Tier 2 FALs were calculated for the radionuclides using site-specific information. The hazardous constituents of TPH-DRO were compared to the PALs</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013GeCoA.102..261W','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013GeCoA.102..261W"><span id="translatedtitle">Petrology, trace element abundances and oxygen isotopic compositions of a compound <span class="hlt">CAI</span>-chondrule object from Allende</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Wakaki, S.; Itoh, S.; Tanaka, T.; Yurimoto, H.</p> <p>2013-02-01</p> <p>We report the petrology, trace element abundances and oxygen isotopic characteristics of a compound <span class="hlt">CAI</span>-chondrule object, WI-025, found in the Allende CV3 chondrite. The WI-025 is an irregularly shaped inclusion consisting of three texturally and chemically distinct portions: the interior portion, the igneous rim and the intermediate zone located between these two portions. The interior portion consists of anorthite, spinel, olivine and Al-bearing low-Ca pyroxene. The major element chemistry of the interior portion corresponds to that of Al-rich chondrules and is of intermediate character between fine-grained spinel-rich <span class="hlt">CAIs</span> and ferromagnesian chondrules. The interior portion has abundant 16O-rich spinel (Δ17O = -14.2 to -24.7) and displays a group II <span class="hlt">CAI</span>-like REE composition. These observations indicate that the interior portion contains a <span class="hlt">CAI</span> component formed by fractional condensation. The major and trace element chemistry of the interior portion indicate that the <span class="hlt">CAI</span> had subsequently assimilated chondrule materials through partial melting. The maximum heating temperature of the partial melting is estimated at approximately 1400 °C, similar to the maximum heating temperature of Type-B <span class="hlt">CAIs</span>. The oxygen isotopic compositions of the olivine and low-Ca pyroxene (Δ17O = -6.3) in the interior portion indicate that the partial melting and chondrule assimilation took place under a moderately 16O-poor nebular gas. The igneous rim is texturally and chemically similar to ferromagnesian chondrules and entirely surrounds the interior portion. The oxygen isotopic compositions of the olivine and low-Ca pyroxene in the igneous rim are indistinguishable from those of the interior olivine and Al-bearing low-Ca pyroxenes. These observations indicate that a chondrule material, which was melted in the same nebular gas as the interior portion, was accreted to the interior portion. The intermediate zone represents a reaction zone accompanying the igneous rim formation. The</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26998562','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26998562"><span id="translatedtitle">Intentional <span class="hlt">action</span> processing results from automatic bottom-up attention: An EEG-<span class="hlt">investigation</span> into the Social Relevance Hypothesis using hypnosis.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Neufeld, Eleonore; Brown, Elliot C; Lee-Grimm, Sie-In; Newen, Albert; Brüne, Martin</p> <p>2016-05-01</p> <p>Social stimuli grab our attention. However, it has rarely been <span class="hlt">investigated</span> how variations in attention affect the processing of social stimuli, although the answer could help us uncover details of social cognition processes such as <span class="hlt">action</span> understanding. In the present study, we examined how changes to bottom-up attention affects neural EEG-responses associated with intentional <span class="hlt">action</span> processing. We induced an increase in bottom-up attention by using hypnosis. We recorded the electroencephalographic μ-wave suppression of hypnotized participants when presented with intentional <span class="hlt">actions</span> in first and third person perspective in a video-clip paradigm. Previous studies have shown that the μ-rhythm is selectively suppressed both when executing and observing goal-directed motor <span class="hlt">actions</span>; hence it can be used as a neural signal for intentional <span class="hlt">action</span> processing. Our results show that neutral hypnotic trance increases μ-suppression in highly suggestible participants when they observe intentional <span class="hlt">actions</span>. This suggests that social <span class="hlt">action</span> processing is enhanced when bottom-up attentional processes are predominant. Our findings support the Social Relevance Hypothesis, according to which social <span class="hlt">action</span> processing is a bottom-up driven attentional process, and can thus be altered as a function of bottom-up processing devoted to a social stimulus. PMID:26998562</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2010PhDT.......128M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2010PhDT.......128M"><span id="translatedtitle">Using discrepant events in science demonstrations to promote student engagement in scientific <span class="hlt">investigations</span>: An <span class="hlt">action</span> research study</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Mancuso, Vincent J.</p> <p></p> <p>Students' scientific <span class="hlt">investigations</span> have been identified in national standards and related reform documents as a critical component of students' learning experiences in school, yet it is not easy to implement them in science classrooms. Could science demonstrations help science teachers put this recommendation into practice? While demonstrations are a common practice in the science classroom and research has documented some positive effects in terms of student motivation and engagement from their use, the literature also shows that, as traditionally presented, science demonstrations do not always achieve their intended outcomes. This, in turn, suggested the value of <span class="hlt">investigating</span> what design elements of demonstrations could be used to promote specific instructional goals. Employing <span class="hlt">action</span> research as a methodology, the proposed study was developed to explore how science demonstrations can be designed so as to most effectively promote student engagement in scientific <span class="hlt">investigations</span>. More specifically, I was interested in examining the effects of using a discrepant event as part of the demonstration, as a way to create cognitive conflict and, thus, increase interest and engagement. I also <span class="hlt">investigated</span> the relative merit of the well-researched POE (Predict, Observe, Explain) design versus employing demonstrations that appear to the student to be unplanned (what I will refer to as NOE, or a Naturally Occurring Experience). This study was informed by Constructivism, Situated Cognition and Conceptual Change as theoretical frameworks. The project included the design, implementation and study of an intervention consisting of three instructional units designed to support students' learning of the concepts of density, molecular arrangement of gas particles, and cohesion, respectively. In each of these units, lasting a total of two 80-minute class periods, students were asked to design and conduct an <span class="hlt">investigation</span> to gain a better understanding of the concept under study. In</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/928510','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/928510"><span id="translatedtitle">Corrective <span class="hlt">Action</span> Decision Document/Closure Report for Corrective <span class="hlt">Action</span> Unit 545: Dumps, Waste Disposal Sites, and Buried Radioactive Materials Nevada Test Site, Nevada, Revision 0</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Alfred Wickline</p> <p>2008-04-01</p> <p> sufficient, and safety concerns existed about the stability of the crater component. Therefore, a corrective <span class="hlt">action</span> of close in place with a use restriction is recommended, and sampling at the site was not considered necessary. The purpose of this CADD/CR is to provide justification and documentation to support the recommendation for closure of CAU 545 with no further corrective <span class="hlt">action</span>. To achieve this, corrective <span class="hlt">action</span> <span class="hlt">investigation</span> (<span class="hlt">CAI</span>) activities were performed from August 20 through November 02, 2007, as set forth in the CAU 545 Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan. The purpose of the <span class="hlt">CAI</span> was to fulfill the following data needs as defined during the DQO process: • Determine whether contaminants of concern (COCs) are present. • If COCs are present, determine their nature and extent. • Provide sufficient information and data to complete appropriate corrective <span class="hlt">actions</span>. The CAU 545 dataset from the <span class="hlt">investigation</span> results was evaluated based on the data quality indicator parameters. This evaluation demonstrated the quality and acceptability of the dataset for use in fulfilling the DQO data needs. Analytes detected during the <span class="hlt">CAI</span> were evaluated against final <span class="hlt">action</span> levels established in this CADD/CR. The results of the <span class="hlt">CAI</span> identified no COCs at the five CASs <span class="hlt">investigated</span> in CAU 545. As a best management practice, repair of the fence enclosing CAS 03-08-03 has been completed. Therefore, the DOE, National Nuclear Security Administration Nevada Site Office provides the following recommendations: • Close in place COCs at CASs 03-08-03 and 03-23-05 with use restrictions. • No further corrective <span class="hlt">action</span> for CAU 545. • No Corrective <span class="hlt">Action</span> Plan. • Corrective <span class="hlt">Action</span> Unit 545 should be moved from Appendix III to Appendix IV of the Federal Facility Agreement and Consent Order. • A Notice of Completion to the DOE, National Nuclear Security Administration Nevada Site Office is requested from the Nevada Division of Environmental Protection for closure of CAU 545.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24826872','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24826872"><span id="translatedtitle">Factors associated with regulatory <span class="hlt">action</span> involving <span class="hlt">investigation</span> of illnesses associated with Shiga toxin-producing Escherichia coli in products regulated by the Food Safety and Inspection Service.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Green, Alice L; Seys, Scott; Douris, Aphrodite; Levine, Jeoff; Robertson, Kis</p> <p>2014-07-01</p> <p>We described characteristics of the Escherichia coli O157 and Escherichia coli non-O157 illness <span class="hlt">investigations</span> conducted by the United States Department of Agriculture's Food Safety and Inspection Service (FSIS) during the 5-year period from 2006 through 2010. We created a multivariable logistic regression model to determine characteristics of these <span class="hlt">investigations</span> that were associated with FSIS regulatory <span class="hlt">action</span>, which was defined as having occurred if a product recall occurred or if FSIS personnel performed an environmental health assessment (Food Safety Assessment) at the implicated establishment. During this period, FSIS took regulatory <span class="hlt">action</span> in 38 of 88 (43%) <span class="hlt">investigations</span>. Illness <span class="hlt">investigations</span> in which FoodNet states were involved were more likely to result in regulatory <span class="hlt">action</span>. Illness <span class="hlt">investigations</span> in which state and local traceback, or FSIS traceback occurred were more likely to result in regulatory <span class="hlt">action</span>. Reasons for lack of <span class="hlt">action</span> included evidence of cross-contamination after the product left a regulated establishment, delayed notification, lack of epidemiological information, and insufficient product information. PMID:24826872</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23148877','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23148877"><span id="translatedtitle">The revised EMA guideline for the <span class="hlt">investigation</span> of bioequivalence for immediate release oral formulations with systemic <span class="hlt">action</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Verbeeck, Roger K; Musuamba, Flora T</p> <p>2012-01-01</p> <p>On August 1, 2010, a revised guidance regarding bioequivalence (BE) assessment for the approval of innovator (bridging studies, variations, line extensions) and generic medicinal products in the EU came into effect (EMA Guideline on the <span class="hlt">Investigation</span> of Bioequivalence, CPMP/EWP/QWP/1401/98 Rev. 1/Corr**, London, 20 January 2010). This guideline specifies the requirements for BE assessment for immediate release oral dosage forms with systemic <span class="hlt">action</span>. Compared to the previous BE guideline of the EMA, clearer guidance is now given on several topics including BE assessment of highly variable drugs/drug products (HVDs/HVDPs), the use of metabolite data, acceptance criteria for narrow therapeutic index drugs (NTIDs), BCS-based biowaivers, and dose strength to be used in case of application for marketing authorization of several strengths. However, the health authorities of the various EU member states do not necessarily apply the same rules as far as substitution and switchability between medicinal products are concerned. Moreover, differences still exist between the BE guidelines of the major health authorities (FDA, EMA, NIHC, ...) on topics such as HVDs/HVDPs, NTIDs and BCS-based biowaivers. Global harmonization should be the next logical step to guarantee accessibility to safe and efficacious drug products for patients in all parts of the world. PMID:23148877</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4157545','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4157545"><span id="translatedtitle">Toward panoramic in situ mapping of <span class="hlt">action</span> potential propagation in transgenic hearts to <span class="hlt">investigate</span> initiation and therapeutic control of arrhythmias</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Dura, Miroslav; Schröder-Schetelig, Johannes; Luther, Stefan; Lehnart, Stephan E.</p> <p>2014-01-01</p> <p>To <span class="hlt">investigate</span> the dynamics and propensity for arrhythmias in intact transgenic hearts comprehensively, optical strategies for panoramic fluorescence imaging of <span class="hlt">action</span> potential (AP) propagation are essential. In particular, mechanism-oriented molecular studies usually depend on transgenic mouse hearts of only a few millimeters in size. Furthermore, the temporal scales of the mouse heart remain a challenge for panoramic fluorescence imaging with heart rates ranging from 200 min−1 (e.g., depressed sinus node function) to over 1200 min−1 during fast arrhythmias. To meet these challenging demands, we and others developed physiologically relevant mouse models and characterized their hearts with planar AP mapping. Here, we summarize the progress toward panoramic fluorescence imaging and its prospects for the mouse heart. In general, several high-resolution cameras are synchronized and geometrically arranged for panoramic voltage mapping and the surface and blood vessel anatomy documented through image segmentation and heart surface reconstruction. We expect that panoramic voltage imaging will lead to novel insights about molecular arrhythmia mechanisms through quantitative strategies and organ-representative analysis of intact mouse hearts. PMID:25249982</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/1121444','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/1121444"><span id="translatedtitle">Phase II Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan for Corrective <span class="hlt">Action</span> Units 101 and 102: Central and Western Pahute Mesa, Nevada Test Site, Nye County, Nevada, Revision 2 with ROTC 1 and 2</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Marutzky, Sam</p> <p>2009-07-01</p> <p>This Phase II CAIP describes new work needed to potentially reduce uncertainty and achieve increased confidence in modeling results. This work includes data collection and data analysis to refine model assumptions, improve conceptual models of flow and transport in a complex hydrogeologic setting, and reduce parametric and structural uncertainty. The work was prioritized based on the potential to reduce model uncertainty and achieve an acceptable level of confidence in the model predictions for flow and transport, leading to model acceptance by NDEP and completion of the Phase II <span class="hlt">CAI</span> stage of the UGTA strategy.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26592707','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26592707"><span id="translatedtitle">Inhibitory control training for appetitive behaviour change: A meta-analytic <span class="hlt">investigation</span> of mechanisms of <span class="hlt">action</span> and moderators of effectiveness.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Jones, Andrew; Di Lemma, Lisa C G; Robinson, Eric; Christiansen, Paul; Nolan, Sarah; Tudur-Smith, Catrin; Field, Matt</p> <p>2016-02-01</p> <p>Inhibitory control training (ICT) is a novel intervention in which participants learn to associate appetitive cues with inhibition of behaviour. We present a meta-analytic <span class="hlt">investigation</span> of laboratory studies of ICT for appetitive behaviour change in which we <span class="hlt">investigate</span> candidate mechanisms of <span class="hlt">action</span>, individual differences that may moderate its effectiveness, and compare it to other psychological interventions. We conducted random-effects generic inverse variance meta-analysis on data from 14 articles (18 effect sizes in total). Participants who received ICT chose or consumed significantly less food or alcohol compared to control groups (SMD = 0.36, 95% CIs [0.24, 0.47]; Z = 6.18, p < .001; I(2) = 71%). Effect sizes were larger for motor (Go/No-Go and Stop Signal) compared to oculomotor (Antisaccade) ICT. The effects of ICT on behaviour were comparable to those produced by other psychological interventions, and effects of ICT on food intake were greater in participants who were attempting to restrict their food intake. The magnitude of the effect of ICT on behaviour was predicted by the proportion of successful inhibitions but was unrelated to the absolute number of trials in which appetitive cues were paired with the requirement to inhibit, or the contingency between appetitive cues and the requirement to inhibit. The effect of ICT on cue devaluation (primarily assessed with implicit association tests) was not statistically significant. Our analysis confirms the efficacy of ICT for short-term behaviour change in the laboratory, and we have demonstrated that its effectiveness may depend on pairings between appetitive cues and successful inhibition. We highlight the need for further research to translate these findings outside of the laboratory. PMID:26592707</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/754307','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/754307"><span id="translatedtitle">Corrective <span class="hlt">action</span> <span class="hlt">investigation</span> plan for Corrective <span class="hlt">Action</span> Unit 143: Area 25 contaminated waste dumps, Nevada Test Site, Nevada, Revision 1 (with Record of Technical Change No. 1 and 2)</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>USDOE Nevada Operations Office</p> <p>1999-06-28</p> <p>This plan contains the US Department of Energy, Nevada Operations Office's approach to collect the data necessary to evaluate correction <span class="hlt">action</span> alternatives appropriate for the closure of Corrective <span class="hlt">Action</span> Unit (CAU) 143 under the Federal Facility Agreement and Consent Order. Corrective <span class="hlt">Action</span> Unit 143 consists of two waste dumps used for the disposal of solid radioactive wastes. Contaminated Waste Dump No.1 (CAS 25-23-09) was used for wastes generated at the Reactor Maintenance Assembly and Disassembly (R-MAD) Facility and Contaminated Waste Dump No.2 (CAS 25-23-03) was used for wastes generated at the Engine Maintenance Assembly and Disassembly (E-MAD) Facility. Both the R-MAD and E-MAD facilities are located in Area 25 of the Nevada Test Site. Based on site history, radionuclides are the primary constituent of concern and are located in these disposal areas; vertical and lateral migration of the radionuclides is unlikely; and if migration has occurred it will be limited to the soil beneath the Contaminated Waste Disposal Dumps. The proposed <span class="hlt">investigation</span> will involve a combination of Cone Penetrometer Testing within and near the solid waste disposal dumps, field analysis for radionuclides and volatile organic compounds, as well as sample collection from the waste dumps and surrounding areas for off-site chemical, radiological, and geotechnical analyses. The results of this field <span class="hlt">investigation</span> will support a defensible evaluation of corrective <span class="hlt">action</span> alternatives in the corrective <span class="hlt">action</span> decision document.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_20 --> <div id="page_21" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="401"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/8530','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/8530"><span id="translatedtitle">Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan for Corrective <span class="hlt">Action</span> Unit 321: Area 22 Weather Station Fuel Storage, Nevada Test Site, Nevada, Revision 0. UPDATED WITH RECORD OF TECHNICAL CHANGE No.1</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>U.S. DOE /NV</p> <p>1999-02-08</p> <p>This Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan (CAIP) has been developed in accordance with the Federal Facility Agreement and Consent Order (FFACO) that was agreed to by the US Department of Energy, Nevada Operations Office (DOE/NV); the State of Nevada Division of Environmental Protection (NDEP); and the US Department of Defense (FFACO, 1996). The CAIP is a document that provides or references all of the specific information for <span class="hlt">investigation</span> activities associated with Corrective <span class="hlt">Action</span> Units (CAUs) or Corrective <span class="hlt">Action</span> Sites (CASs). According to the FFACO (1996), CASs are sites potentially requiring corrective <span class="hlt">action(s</span>) and may include solid waste management units or individual disposal or release sites. A CAU consists of one or more CASs grouped together based on geography, technical similarity, or agency responsibility for the purpose of determining corrective <span class="hlt">actions</span>. This CAIP contains the environmental sample collection objectives and the criteria for conducting site <span class="hlt">investigation</span> activities at the CAU 321 Area 22 Weather Station Fuel Storage, CAS 22-99-05 Fuel Storage Area. For purposes of this discussion, this site will be referred to as either CAU 321 or the Fuel Storage Area. The Fuel Storage Area is located in Area 22 of the Nevada Test Site (NTS). The NTS is approximately 105 kilometers (km) (65 miles [mi]) northwest of Las Vegas, Nevada (DOE/NV, 1996a). The Fuel Storage Area was used to store fuel and other petroleum products necessary for motorized operations at the historic Camp Desert Rock facility which was operational from 1951 to 1958 at the Nevada Test Site, Nevada. The site was dismantled after 1958 (DOE/NV, 1996a).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013GeCoA.116...52R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013GeCoA.116...52R"><span id="translatedtitle">The texture of a fine-grained calcium-aluminium-rich inclusion (<span class="hlt">CAI</span>) in three dimensions and implications for early solar system condensation</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Russell, Sara S.; Howard, Lauren</p> <p>2013-09-01</p> <p>A 16 mm fine-grained spinel-rich calcium-aluminium-rich inclusion (<span class="hlt">CAI</span>) from the Allende CV3 meteorite was analysed using nano-computed tomography and scanning electron microscopy on uncoated chips and a polished thin section. The <span class="hlt">CAI</span> is composed of spinel nodules surrounded by anorthite and Al-rich diopside rims. Minor secondary minerals including hedenbergite and nepheline are also present. The uncoated chips contain abundant wollastonite needles that are only rarely observed in the thin section. Nano-computed tomography shows that the structure of the <span class="hlt">CAI</span> is a branching interconnected network of nodules, most of which are attached to each other in three dimensions. However some nodules are unattached to the rest of the <span class="hlt">CAI</span>. The texture suggests that the <span class="hlt">CAI</span> formed by condensation from a gas, and condensation and aggregation of nodules occurred contemporaneously, implying a high density of newly-formed dust. One portion of the <span class="hlt">CAI</span> is compact and rich in melilite, with a composition and texture dissimilar to the bulk of the inclusion. We infer that this is a melilite-rich mantle of the same <span class="hlt">CAI</span> that has experienced melting on one side.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/1055472','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/1055472"><span id="translatedtitle">Corrective <span class="hlt">Action</span> Decision Document/Corrective <span class="hlt">Action</span> Plan for Corrective <span class="hlt">Action</span> Unit 104: Area 7 Yucca Flat Atmospheric Test Sites Nevada National Security Site, Nevada, Revision 0</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Patrick Matthews</p> <p>2012-10-01</p> <p>CAU 104 comprises the following corrective <span class="hlt">action</span> sites (CASs): • 07-23-03, Atmospheric Test Site T-7C • 07-23-04, Atmospheric Test Site T7-1 • 07-23-05, Atmospheric Test Site • 07-23-06, Atmospheric Test Site T7-5a • 07-23-07, Atmospheric Test Site - Dog (T-S) • 07-23-08, Atmospheric Test Site - Baker (T-S) • 07-23-09, Atmospheric Test Site - Charlie (T-S) • 07-23-10, Atmospheric Test Site - Dixie • 07-23-11, Atmospheric Test Site - Dixie • 07-23-12, Atmospheric Test Site - Charlie (Bus) • 07-23-13, Atmospheric Test Site - Baker (Buster) • 07-23-14, Atmospheric Test Site - Ruth • 07-23-15, Atmospheric Test Site T7-4 • 07-23-16, Atmospheric Test Site B7-b • 07-23-17, Atmospheric Test Site - Climax These 15 CASs include releases from 30 atmospheric tests conducted in the approximately 1 square mile of CAU 104. Because releases associated with the CASs included in this CAU overlap and are not separate and distinguishable, these CASs are addressed jointly at the CAU level. The purpose of this CADD/CAP is to evaluate potential corrective <span class="hlt">action</span> alternatives (CAAs), provide the rationale for the selection of recommended CAAs, and provide the plan for implementation of the recommended CAA for CAU 104. Corrective <span class="hlt">action</span> <span class="hlt">investigation</span> (<span class="hlt">CAI</span>) activities were performed from October 4, 2011, through May 3, 2012, as set forth in the CAU 104 Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/792883','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/792883"><span id="translatedtitle">Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan for Corrective <span class="hlt">Action</span> Unit 165: Areas 25 and 26 Dry Well and Washdown Areas, Nevada Test Site, Nevada (including Record of Technical Change Nos. 1, 2, and 3) (January 2002, Rev. 0)</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office</p> <p>2002-01-09</p> <p>This Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan contains the U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office's approach to collect the data necessary to evaluate corrective <span class="hlt">action</span> alternatives appropriate for the closure of Corrective <span class="hlt">Action</span> Unit (CAU) 165 under the Federal Facility Agreement and Consent Order. Corrective <span class="hlt">Action</span> Unit 165 consists of eight Corrective <span class="hlt">Action</span> Sites (CASs): CAS 25-20-01, Lab Drain Dry Well; CAS 25-51-02, Dry Well; CAS 25-59-01, Septic System; CAS 26-59-01, Septic System; CAS 25-07-06, Train Decontamination Area; CAS 25-07-07, Vehicle Washdown; CAS 26-07-01, Vehicle Washdown Station; and CAS 25-47-01, Reservoir and French Drain. All eight CASs are located in the Nevada Test Site, Nevada. Six of these CASs are located in Area 25 facilities and two CASs are located in Area 26 facilities. The eight CASs at CAU 165 consist of dry wells, septic systems, decontamination pads, and a reservoir. The six CASs in Area 25 are associated with the Nuclear Rocket Development Station that operated from 1958 to 1973. The two CASs in Area 26 are associated with facilities constructed for Project Pluto, a series of nuclear reactor tests conducted between 1961 to 1964 to develop a nuclear-powered ramjet engine. Based on site history, the scope of this plan will be a two-phased approach to <span class="hlt">investigate</span> the possible presence of hazardous and/or radioactive constituents at concentrations that could potentially pose a threat to human health and the environment. The Phase I analytical program for most CASs will include volatile organic compounds, semivolatile organic compounds, Resource Conservation and Recovery Act metals, total petroleum hydrocarbons, polychlorinated biphenyls, and radionuclides. If laboratory data obtained from the Phase I <span class="hlt">investigation</span> indicates the presence of contaminants of concern, the process will continue with a Phase II <span class="hlt">investigation</span> to define the extent of contamination. Based on the results of</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/859368','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/859368"><span id="translatedtitle">Corrective <span class="hlt">Action</span> Decision Document for Corrective <span class="hlt">Action</span> Unit 204: Storage Bunkers, Nevada Test Site, Nevada, Revision 0 with ROTC 1, 2, and Errata</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Wickline, Alfred</p> <p>2004-04-01</p> <p>This Corrective <span class="hlt">Action</span> Decision Document (CADD) has been prepared for Corrective <span class="hlt">Action</span> Unit (CAU) 204 Storage Bunkers, Nevada Test Site (NTS), Nevada, in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) that was agreed to by the State of Nevada; U.S. Department of Energy (DOE); and the U.S. Department of Defense (FFACO, 1996). The NTS is approximately 65 miles (mi) north of Las Vegas, Nevada (Figure 1-1). The Corrective <span class="hlt">Action</span> Sites (CASs) within CAU 204 are located in Areas 1, 2, 3, and 5 of the NTS, in Nye County, Nevada (Figure 1-2). Corrective <span class="hlt">Action</span> Unit 204 is comprised of the six CASs identified in Table 1-1. As shown in Table 1-1, the FFACO describes four of these CASs as bunkers one as chemical exchange storage and one as a blockhouse. Subsequent <span class="hlt">investigations</span> have identified four of these structures as instrumentation bunkers (CASs 01-34-01, 02-34-01, 03-34-01, 05-33-01), one as an explosives storage bunker (CAS 05-99-02), and one as both (CAS 05-18-02). The six bunkers included in CAU 204 were primarily used to monitor atmospheric testing or store munitions. The ''Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan (CAIP) for Corrective <span class="hlt">Action</span> Unit 204: Storage Bunkers, Nevada Test Site, Nevada'' (NNSA/NV, 2002a) provides information relating to the history, planning, and scope of the <span class="hlt">investigation</span>; therefore, it will not be repeated in this CADD. This CADD identifies potential corrective <span class="hlt">action</span> alternatives and provides a rationale for the selection of a recommended corrective <span class="hlt">action</span> alternative for each CAS within CAU 204. The evaluation of corrective <span class="hlt">action</span> alternatives is based on process knowledge and the results of <span class="hlt">investigative</span> activities conducted in accordance with the CAIP (NNSA/NV, 2002a) that was approved prior to the start of the Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> (<span class="hlt">CAI</span>). Record of Technical Change (ROTC) No. 1 to the CAIP (approval pending) documents changes to the preliminary <span class="hlt">action</span> levels (PALs) agreed to by the Nevada Division</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015M%26PS...50.1512I','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015M%26PS...50.1512I"><span id="translatedtitle">A compound Ca-, Al-rich inclusion from CV3 chondrite Northwest Africa 3118: Implications for understanding processes during <span class="hlt">CAI</span> formation</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ivanova, Marina A.; Lorenz, Cyril A.; Krot, Alexander N.; MacPherson, Glenn J.</p> <p>2015-09-01</p> <p>A calcium-aluminum-rich inclusion 3N from the Northwest Africa (NWA) 3118 CV3 carbonaceous chondrite is a unique cm-sized compound object, primarily a forsterite-bearing type B (FoB) <span class="hlt">CAI</span>, that encloses at least 26 smaller <span class="hlt">CAIs</span> of different types, including compact type A (CTA), B, C, and an ultra-refractory inclusion. Relative to typical type A and B <span class="hlt">CAIs</span> found elsewhere, the bulk compositions of the types A and B <span class="hlt">CAIs</span> within 3N more closely match the bulk compositions predicted by equilibrium condensation of a gas of solar composition. Being trapped within the FoB melt may have protected them from melt evaporation that affected most "stand-alone" <span class="hlt">CAIs</span>. 3N originated either as an aggregate of many smaller (mostly types A, B, C) <span class="hlt">CAIs</span> plus accreted Fo-bearing material (like an amoeboid olivine aggregate) which experienced partial melting of the whole, or else as a FoB melt droplet that collided with and trapped many smaller solid <span class="hlt">CAIs</span>. In the former case, 3N recorded the earliest accretion of pebble-sized bodies known. In the latter case, the presence of a large number of individual refractory inclusions within 3N suggests a very high local density of refractory solids in the immediate region of the host <span class="hlt">CAI</span> during the brief time while it was melted. Collisions would have occurred on time scales of hours at most, assuming a melt solidification interval for the host <span class="hlt">CAI</span> of 300-400 °C (maximum) and a cooling rate of ~10 °C/h.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/782550','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/782550"><span id="translatedtitle">Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan for Corrective <span class="hlt">Action</span> Unit 405: Area 3 Septic Systems, Tonopah Test Range, Nevada(April 2001, Rev. 0) with Record of Technical Change No. 1</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>DOE /NV</p> <p>2001-04-26</p> <p>This Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan contains the U.S. Department of Energy, Nevada Operations Office's (DOE/NV's) approach to collect the data necessary to evaluate corrective <span class="hlt">action</span> alternatives appropriate for the closure of Corrective <span class="hlt">Action</span> Unit (CAU) 405, Area 3 Septic Systems, Tonopah Test Range (TTR), under the Federal Facility Agreement and Consent Order. Corrective <span class="hlt">Action</span> Unit 405 consists of Corrective <span class="hlt">Action</span> Sites 03-05-002-SW03, 03-05-002-SW04, and 03-05-002-SW07 (also collectively known as: Septic Waste Systems [SWSs] 3, 4, and 7). Located in Area 3 in the northwest section of the TTR, approximately 140 miles northwest of Las Vegas, this location was historically (between 1960 and 1990) used as a research facility with the mission to perform defense-related projects, and whose operations generated sanitary and industrial wastewaters potentially contaminated with COPCs and disposed of in septic tanks and leachfields. Though Septic Waste Systems 3, 4, and 7 were origin ally constructed to receive sanitary sewage, they may have inadvertently received effluent containing potentially hazardous and radiological constituents containing acetone, benzene, ethylbenzene, 4-methyl-2-pentanone, toluene, xylenes, volatile organic compound constituents, phenols, arsenic, barium, lead, mercury, hydrocarbons of oil and grease, and uranium-234, -235, and -238. The Area 3 septic systems were documented in a DOE/NV 1996 report as being included in the septic tank abandonment program conducted by Sandia National Laboratories in 1993; however, this program was not completed and the possibility exists that some of the Area 3 septic tanks may not have been abandoned. Even though all of the SWSs addressed in this CAIP are inactive, geophysical surveys conducted in 1993 were generally inconclusive and did not provide useful data for the purposes of this <span class="hlt">investigation</span>. The scope of this current <span class="hlt">investigation</span>, therefore, will be to determine the existence of the identified</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/16681805','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/16681805"><span id="translatedtitle">In vitro <span class="hlt">investigations</span> on the mode of <span class="hlt">action</span> of the hydroxypyridone antimycotics rilopirox and piroctone on Candida albicans.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sigle, H C; Schäfer-Korting, M; Korting, H C; Hube, B; Niewerth, M</p> <p>2006-05-01</p> <p>Rilopirox and piroctone belong to the class of hydroxypyridone antimycotics. This class is not related to other antimycotics. In contrast to azole antimycotics and polyene antimycotics the mode of <span class="hlt">action</span> of hydroxypyridone antimycotics is not fully understood. Inhibition of cellular uptake of essential compounds as well as loss of other compounds seems to be only a secondary effect of a primary not known <span class="hlt">action</span> of these drugs. The antifungal effect in vitro depends on the medium used. The hyphal induction of Candida albicans is inhibited by hydroxypyridone antimycotics, but this effect is compensated by iron ions. A damage of the cell membrane and a direct influence on adenosine triphosphate synthesis, respectively, do not seem to be part of the mode of <span class="hlt">action</span>. But there are clear hints that reactive oxygen species (ROS) and available metabolic activity are important parts of the mode of <span class="hlt">action</span> of the hydroxypyridone antimycotics rilopirox and piroctone. PMID:16681805</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016EGUGA..1817965B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016EGUGA..1817965B"><span id="translatedtitle">Ground-penetrating radar <span class="hlt">investigation</span> of St. Leonard's Crypt under the Wawel Cathedral (Cracow, Poland) - COST <span class="hlt">Action</span> TU1208</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Benedetto, Andrea; Pajewski, Lara; Dimitriadis, Klisthenis; Avlonitou, Pepi; Konstantakis, Yannis; Musiela, Małgorzata; Mitka, Bartosz; Lambot, Sébastien; Żakowska, Lidia</p> <p>2016-04-01</p> <p> "Applications of Ground Penetrating Radar in urban areas: the sensitive case of historical cities." The <span class="hlt">Action</span> TU1208 is coordinated by "Roma Tre University" (Rome, Italy) and the TS was hosted by the Cracow University of Technology (Cracow, Poland). It was attended by 25 PhD students and early-career <span class="hlt">investigators</span> coming from Albania, Belgium, Germany, Italy, Poland, Romania, Russia and Slovenia. Trainers and Trainees had the great honour and privilege to carry out practical sessions in St Leonard's Crypt, in cooperation with the companies Restauro (Toruń, Poland) and Geoservice (Athens, Greece). Over the centuries, city centres have been continuously changing, developing and adapting to the requirements of society, architectural planning and advancing technology. Under the pressure of urbanisation, many cities and towns have significantly expanded and the limited space in their centres has been exploited more intensively. The shallow subsurface of historical cities is nowadays a very complicated scenario including reams of pipes, cables, rubble, bars and slabs of reinforced concrete, backfilled excavation trenches and pits, cellars, wells, cavities, tunnels, graves, walls and foundations of former houses, churches, monasteries, town fortifications, along with several other modern and ancient structures and manufacts. For the prospection of such a diversified, multilayered, intricate and complex underground environment, both for archaeological and civil-engineering purposes, Ground Penetrating Radar (GPR) is a very effective non-destructive geophysical method. GPR is a powerful tool not only for the prospection of subsurface but also for the non-invasive testing of historical buildings, fountains, historical bridges, sculptures, frescoes, pottery and other objects collected in museums: it can give information about their state of preservation, it can significantly help to address a restoration project properly, and sometimes it can also help to achieve information of</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2016EGUGA..1817965B&link_type=ABSTRACT','NASAADS'); return false;" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2016EGUGA..1817965B&link_type=ABSTRACT"><span id="translatedtitle">Ground-penetrating radar <span class="hlt">investigation</span> of St. Leonard's Crypt under the Wawel Cathedral (Cracow, Poland) - COST <span class="hlt">Action</span> TU1208</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Benedetto, Andrea; Pajewski, Lara; Dimitriadis, Klisthenis; Avlonitou, Pepi; Konstantakis, Yannis; Musiela, Małgorzata; Mitka, Bartosz; Lambot, Sébastien; Żakowska, Lidia</p> <p>2016-04-01</p> <p> "Applications of Ground Penetrating Radar in urban areas: the sensitive case of historical cities." The <span class="hlt">Action</span> TU1208 is coordinated by "Roma Tre University" (Rome, Italy) and the TS was hosted by the Cracow University of Technology (Cracow, Poland). It was attended by 25 PhD students and early-career <span class="hlt">investigators</span> coming from Albania, Belgium, Germany, Italy, Poland, Romania, Russia and Slovenia. Trainers and Trainees had the great honour and privilege to carry out practical sessions in St Leonard's Crypt, in cooperation with the companies Restauro (Toruń, Poland) and Geoservice (Athens, Greece). Over the centuries, city centres have been continuously changing, developing and adapting to the requirements of society, architectural planning and advancing technology. Under the pressure of urbanisation, many cities and towns have significantly expanded and the limited space in their centres has been exploited more intensively. The shallow subsurface of historical cities is nowadays a very complicated scenario including reams of pipes, cables, rubble, bars and slabs of reinforced concrete, backfilled excavation trenches and pits, cellars, wells, cavities, tunnels, graves, walls and foundations of former houses, churches, monasteries, town fortifications, along with several other modern and ancient structures and manufacts. For the prospection of such a diversified, multilayered, intricate and complex underground environment, both for archaeological and civil-engineering purposes, Ground Penetrating Radar (GPR) is a very effective non-destructive geophysical method. GPR is a powerful tool not only for the prospection of subsurface but also for the non-invasive testing of historical buildings, fountains, historical bridges, sculptures, frescoes, pottery and other objects collected in museums: it can give information about their state of preservation, it can significantly help to address a restoration project properly, and sometimes it can also help to achieve information of</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/10178334','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/10178334"><span id="translatedtitle">[Environmental <span class="hlt">investigation</span> of ground water contamination at Wright-Patterson Air Force Base, Ohio]. Volume 9, Removal <span class="hlt">action</span> system design</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Not Available</p> <p>1992-04-01</p> <p>This Removal <span class="hlt">Action</span> System Design has been prepared as a Phase I Volume for the implementation of the Phase II removal <span class="hlt">action</span> at Wright-Patterson Air Force Base (WPAFB) near Dayton, Ohio. The objective of the removal <span class="hlt">action</span> is to prevent, to the extent practicable, the migration of ground water contaminated with chlorinated volatile organic compounds (VOCS) across the southwest boundary of Area C. The Phase 1, Volume 9 Removal <span class="hlt">Action</span> System Design compiles the design documents prepared for the Phase II Removal <span class="hlt">Action</span>. These documents, which are presented in Appendices to Volume 9, include: Process Design, which presents the 30 percent design for the ground water treatment system (GWTS); Design Packages 1 and 2 for Earthwork and Road Construction, and the Discharge Pipeline, respectively; no drawings are included in the appendix; Design Package 3 for installation of the Ground Water Extraction Well(s); Design Package 4 for installation of the Monitoring Well Instrumentation; and Design Package 5 for installation of the Ground Water Treatment System; this Design Package is incorporated by reference because of its size.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2009GeCoA..73.5100P&link_type=ABSTRACT','NASAADS'); return false;" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2009GeCoA..73.5100P&link_type=ABSTRACT"><span id="translatedtitle">Petrologic study of SJ101, a new forsterite-bearing <span class="hlt">CAI</span> from the Allende CV3 chondrite</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Petaev, Michail I.; Jacobsen, Stein B.</p> <p>2009-09-01</p> <p>The forsterite-bearing Type B (FoB) <span class="hlt">CAI</span> SJ101 consists of three major structural units: (1) light patches of sector-zoned, poikilitic Al-rich clinopyroxene (Cpx) with numerous inclusions of small spinel grains and aggregates and subordinate amounts of Mg-rich melilite (Mel) and anorthite (An) (Sp-Cpx lithology), (2) dark sinuous bands of Al-rich clinopyroxene with large (up to ˜300 × 60 μm) poikilitically enclosed euhedral forsterite (Fo) crystals (Fo-Cpx lithology), and (3) the external Cpx-Sp-An rim overlying the entire inclusion. The two major lithologies are always separated by a transition zone of clinopyroxene poikilitically enclosing both forsterite and spinel. The patches of the Sp-Cpx lithology exhibit significant textural and mineralogical variability that is size-dependent. Small patches typically consist of Cpx and spinel with minor remnants of melilite and/or its alteration products. Large patches contain Mel-An-rich cores with either equigranular-ophitic-subophitic or 'lacy' textures reminiscent of those in Types B or C <span class="hlt">CAIs</span>, respectively. All silicates poikilitically enclose numerous spinel grains of identical habit. Both melilite and anorthite gradually disappear toward the boundary with the Fo-Cpx lithology. Neither the evaporation mantle of Al-rich melilite typical of other FoBs nor the Wark-Lovering rim is present. Secondary minerals include grossular, monticellite, magnetite, and a few grains of wollastonite, andradite, and nepheline. Being a rather typical FoB mineralogically and chemically, texturally SJ101 differs from other FoBs in displaying the nearly complete segregation of forsterite from spinel which occur only in the Fo-Cpx and Sp-Cpx lithologies, respectively. The complex, convoluted internal structure of SJ101 suggests that the coarse-grained Sp-An-Mel-Cpx cores and Fo-Cpx lithology represent the precursor materials of FoBs, proto-<span class="hlt">CAIs</span> and Fo-rich accretionary rims. While the inferred chemistry and mineralogy of the Fo-rich rims</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1994Metic..29..461E','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1994Metic..29..461E"><span id="translatedtitle">Efremovka E49: A compact type-A <span class="hlt">CAI</span> containing a partially molten spinel-melilite-diopside xenolith</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>El Goresy, A.; Zinner, E. K.</p> <p>1994-07-01</p> <p>Eframovka E49 is a triangular 2-mm segment from a Compact Type A (CTA) inclusion with large portions of intact core and rim sequence. It is probably a fragment from an originally round approximately equal to 4-mm Ca-Al rich Inclusion (<span class="hlt">CAI</span>). The core consists of two lithologically different assemblages: (1) The major portion of the <span class="hlt">CAI</span> contains melilite sprinkled with rare spinel, perovskite, and the new Ca-Ti silicate. It is covered by a six-layer rim consisting of (from the interior outward): two layers of Zr- and Y-rich perovskite, spinel, Al-diopside, diopside, and forsteritic olivine. (2) A 650-micron wide complex xenolith contains coarse spinel, melilite, perovskite, and metal in its interior, surrounded by a broad shell of Al-diopside, diopside, and minor fassaite and anorthite, and in the rim fassaite yields Al-diopside yields diopside. Coarse spinels abundantly display resorbtion outlines and some of the grains have been broken down to several amoeboid fragments floating in the eutectic assemblage. All these textures are evidence of local melting of the xenolith followed by fast cooling. No such features are observed in the host <span class="hlt">CAI</span>. Since melting is confined to the xenolith, the melt event must have predated its capture into the core of E49. Ion microprobe trace-element studies reveal distinct differences between Rare Earth Element (REE) abundances in perovskites in the xenolith and the host <span class="hlt">CAI</span>. Perovskites in the xenolith display REE patterns with prominent Yb and small Ce excesses and large Eu depletions. Perovskites in the xenolith show higher abundances of Nb, Zr, and V. Magnesium in xenolith and the host is almost unfractionated. Excesses of Mg-26 are found both in the xenolith and the host with data points plotting along a line with a slope of 4 x 105. This is in accord with the petrographic interpretation and indicates that the melting of the xenolith and its capture in E49 took place early.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://ntrs.nasa.gov/search.jsp?R=19950012911&hterms=Fractionation&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D60%26Ntt%3DFractionation','NASA-TRS'); return false;" href="http://ntrs.nasa.gov/search.jsp?R=19950012911&hterms=Fractionation&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D60%26Ntt%3DFractionation"><span id="translatedtitle">Heating during solar nebula formation and Mg isotopic fractionation in precursor grains of <span class="hlt">CAIs</span> and chondrules</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Sasaki, S.; Nagahara, H.; Kitagami, K.; Nakagawa, Y.</p> <p>1994-01-01</p> <p>In some Ca-Al-rich inclusion (<span class="hlt">CAI</span>) grains, mass-dependent isotopic fractionations of Mg, Si, and O are observed and large Mg isotopic fractionation is interpreted to have been produced by cosmochemical processes such as evaporation and condensation. Mass-dependent Mg isotopic fractionation was found in olivine chondrules of Allende meteorites. Presented is an approximate formula for the temperature of the solar nebula that depends on heliocentric distance and the initial gas distribution. Shock heating during solar nebula formation can cause evaporative fractionation within interstellar grains involved in a gas at the inner zone (a less than 3 AU) of the disk. Alternatively collision of late-accreting gas blobs might cause similar heating if Sigma(sub s) and Sigma are large enough. Since the grain size is small, the solid/gas mass ratio is low and solar (low P(sub O2)), and the ambient gas pressure is low, this heating event could not produce chondrules themselves. Chondrule formation should proceed around the disk midplane after dust grains would grow and sediment to increase the solid/gas ratio there. The heating source there is uncertain, but transient rapid accretion through the disk could release a large amount of heat, which would be observed as FU Orionis events.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/9589','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/9589"><span id="translatedtitle">Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan for Corrective <span class="hlt">Action</span> Unit 406: Area 3 Building 03-74 and Building 03-58 Under ground Discharge Points and Corrective <span class="hlt">Action</span> Unit 429: Area 3 Building 03-55 and Area 9 Building 09-52 Underground Discharge Points, Tonopah Test Range, Nevada</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>DOE /NV</p> <p>1999-05-20</p> <p>This Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan (CAIP) has been developed in accordance with the Federal Facility Agreement and Consent Order (FFACO) that was agreed to by the US Department of Energy, Nevada Operations Office (DOE/NV); the State of Nevada Division of Environmental Protection (NDEP); and the US Department of Defense (FFACO, 1996). The CAIP is a document that provides or references all of the specific information for <span class="hlt">investigation</span> activities associated with Corrective <span class="hlt">Action</span> Units (CAUs) or Corrective <span class="hlt">Action</span> Sites (CASs). According to the FFACO (1996), CASs are sites potentially requiring corrective <span class="hlt">action(s</span>) and may include solid waste management units or individual disposal or release sites. Corrective <span class="hlt">Action</span> Units consist of one or more CASs grouped together based on geography, technical similarity, or agency responsibility for the purpose of determining corrective <span class="hlt">actions</span>. This CAIP contains the environmental sample collection objectives and the criteria for conducting site <span class="hlt">investigation</span> activities at the Underground Discharge Points (UDPs) included in both CAU 406 and CAU 429. The CAUs are located in Area 3 and Area 9 of the Tonopah Test Range (TTR). The TTR, included in the Nellis Air Force Range, is approximately 255 kilometers (km) (140 miles [mi]) northwest of Las Vegas, Nevada.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/799771','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/799771"><span id="translatedtitle">Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan for Corrective <span class="hlt">Action</span> Unit 5: Landfills, Nevada Test Site, Nevada (Rev. No.: 0) includes Record of Technical Change No. 1 (dated 9/17/2002)</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>IT Corporation, Las Vegas, NV</p> <p>2002-05-28</p> <p>This Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan contains the U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office's approach to collect the data necessary to evaluate corrective <span class="hlt">action</span> alternatives appropriate for the closure of Corrective <span class="hlt">Action</span> Unit (CAU) 5 under the Federal Facility Agreement and Consent Order. Corrective <span class="hlt">Action</span> Unit 5 consists of eight Corrective <span class="hlt">Action</span> Sites (CASs): 05-15-01, Sanitary Landfill; 05-16-01, Landfill; 06-08-01, Landfill; 06-15-02, Sanitary Landfill; 06-15-03, Sanitary Landfill; 12-15-01, Sanitary Landfill; 20-15-01, Landfill; 23-15-03, Disposal Site. Located between Areas 5, 6, 12, 20, and 23 of the Nevada Test Site (NTS), CAU 5 consists of unlined landfills used in support of disposal operations between 1952 and 1992. Large volumes of solid waste were produced from the projects which used the CAU 5 landfills. Waste disposed in these landfills may be present without appropriate controls (i.e., use restrictions, adequate cover) and hazardous and/or radioactive constituents may be present at concentrations and locations that could potentially pose a threat to human health and/or the environment. During the 1992 to 1995 time frame, the NTS was used for various research and development projects including nuclear weapons testing. Instead of managing solid waste at one or two disposal sites, the practice on the NTS was to dispose of solid waste in the vicinity of the project. A review of historical documentation, process knowledge, personal interviews, and inferred activities associated with this CAU identified the following as potential contaminants of concern: volatile organic compounds, semivolatile organic compounds, polychlorinated biphenyls, pesticides, petroleum hydrocarbons (diesel- and gasoline-range organics), Resource Conservation and Recovery Act Metals, plus nickel and zinc. A two-phase approach has been selected to collect information and generate data to satisfy needed resolution criteria</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Electrical+AND+engineering&pg=5&id=EJ1023351','ERIC'); return false;" href="http://eric.ed.gov/?q=Electrical+AND+engineering&pg=5&id=EJ1023351"><span id="translatedtitle">Facilitating the Learning Process in Design-Based Learning Practices: An <span class="hlt">Investigation</span> of Teachers' <span class="hlt">Actions</span> in Supervising Students</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Gómez Puente, S. M.; van Eijck, M.; Jochems, W.</p> <p>2013-01-01</p> <p>Background: In research on design-based learning (DBL), inadequate attention is paid to the role the teacher plays in supervising students in gathering and applying knowledge to design artifacts, systems, and innovative solutions in higher education. Purpose: In this study, we examine whether teacher <span class="hlt">actions</span> we previously identified in the DBL…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=negative+AND+feedback+AND+works&pg=4&id=EJ987417','ERIC'); return false;" href="http://eric.ed.gov/?q=negative+AND+feedback+AND+works&pg=4&id=EJ987417"><span id="translatedtitle"><span class="hlt">Investigating</span> the Value of Restorative Practice: An <span class="hlt">Action</span> Research Study of One Boy in a Mixed Secondary School</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Standing, Vicky; Fearon, Colm; Dee, Tim</p> <p>2012-01-01</p> <p>Purpose: In response to an increasingly high level of exclusion rates for boys within secondary school in the UK, this study seeks to explore the value of restorative practice and justice for changing student behaviour. Design/methodology/approach: As a piece of <span class="hlt">action</span> research, the authors aimed to look at how methods of restorative practice…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/978879','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/978879"><span id="translatedtitle">Corrective <span class="hlt">Action</span> Decision Document/Closure Report for Corrective <span class="hlt">Action</span> Unit 560: Septic Systems, Nevada Test Site, Nevada, Revision 0</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Grant Evenson</p> <p>2010-04-01</p> <p>Corrective <span class="hlt">Action</span> Unit 560 comprises seven corrective <span class="hlt">action</span> sites (CASs): •03-51-01, Leach Pit •06-04-02, Septic Tank •06-05-03, Leach Pit •06-05-04, Leach Bed •06-59-03, Building CP-400 Septic System •06-59-04, Office Trailer Complex Sewage Pond •06-59-05, Control Point Septic System The purpose of this CADD/CR is to provide justification and documentation supporting the recommendation for closure of CAU 560 with no further corrective <span class="hlt">action</span>. To achieve this, corrective <span class="hlt">action</span> <span class="hlt">investigation</span> (<span class="hlt">CAI</span>) activities were performed from October 7, 2008, through February 24, 2010, as set forth in the Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan for Corrective <span class="hlt">Action</span> Unit 560: Septic Systems, Nevada Test Site, Nevada, and Record of Technical Change No. 1. The purpose of the <span class="hlt">CAI</span> was to fulfill the following data needs as defined during the data quality objective (DQO) process: •Determine whether contaminants of concern (COCs) are present. •If COCs are present, determine their nature and extent. •Provide sufficient information and data to complete appropriate corrective <span class="hlt">actions</span>. The CAU 560 dataset from the <span class="hlt">investigation</span> results was evaluated based on the data quality indicator parameters. This evaluation demonstrated the quality and acceptability of the dataset for use in fulfilling the DQO data needs. Analytes detected during the <span class="hlt">CAI</span> were evaluated against final <span class="hlt">action</span> levels (FALs) established in this document. The following contaminants were determined to be present at concentrations exceeding their corresponding FALs: •No contamination exceeding the FALs was identified at CASs 03-51-01, 06-04-02, and 06-59-04. •The soil at the base of the leach pit chamber at CAS 06-05-03 contains arsenic above the FAL of 23 milligrams per kilogram (mg/kg) and polychlorinated biphenyl (PCBs) above the FAL of 0.74 mg/kg, confined vertically from a depth of approximately 5 to 20 feet (ft) below ground surface. The contamination is confined laterally to the walls of the</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/9840748','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/9840748"><span id="translatedtitle">Evaluation of neutralized chemical agent identification sets (<span class="hlt">CAIS</span>) for skin injury with an overview of the vesicant potential of agent degradation products.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Olajos, E J; Olson, C T; Salem, H; Singer, A W; Hayes, T L; Menton, R G; Miller, T L; Rosso, T; MacIver, B</p> <p>1998-01-01</p> <p>Vesication and skin irritation studies were conducted in hairless guinea-pigs to determine the vesicant and skin irritation potential of chemically-neutralized Chemical Agent Identification Sets (<span class="hlt">CAIS</span>). The <span class="hlt">CAIS</span> are training items that contain chemical warfare-related material--sulfur mustard (HD), nitrogen mustard (HN) or lewisite (L)--and were declared obsolete in 1971. Animals were dosed topically with 'test article'--neat HD, 10% agent/chloroform solutions or product solutions (waste-streams) from neutralized <span class="hlt">CAIS</span>--and evaluated for skin-damaging effects (gross and microscopic). Product solutions from the chemical neutralization of neat sulfur mustard resulted in microvesicle formation. All agent-dosed (HD or agent/chloroform solutions) sites manifested microblisters as well as other histopathological lesions of the skin. Waste-streams from the neutralization of agent (agent/chloroform or agent/charcoal) were devoid of vesicant activity. Cutaneous effects (erythema and edema) were consistent with the skin-injurious activity associated with the neutralizing reagent 1,3-dichloro-5,5-dimethylhydantoin (DCDMH). Chemical neutralization of <span class="hlt">CAIS</span> was effective in eliminating/reducing the vesicant property of <span class="hlt">CAIS</span> containing agent in chloroform or agent on charcoal but was inefficient in reducing the vesicant potential of <span class="hlt">CAIS</span> containing neat sulfur mustard.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_21 --> <div id="page_22" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="421"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2008E%26PSL.272..353J','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2008E%26PSL.272..353J"><span id="translatedtitle">26Al- 26Mg and 207Pb- 206Pb systematics of Allende <span class="hlt">CAIs</span>: Canonical solar initial 26Al/ 27Al ratio reinstated</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Jacobsen, Benjamin; Yin, Qing-zhu; Moynier, Frederic; Amelin, Yuri; Krot, Alexander N.; Nagashima, Kazuhide; Hutcheon, Ian D.; Palme, Herbert</p> <p>2008-07-01</p> <p>The precise knowledge of the initial 26Al/ 27Al ratio [( 26Al/ 27Al) 0] is crucial if we are to use the very first solid objects formed in our Solar System, calcium-aluminum-rich inclusions (<span class="hlt">CAIs</span>) as the "time zero" age-anchor and guide future work with other short-lived radio-chronometers in the early Solar System, as well as determining the inventory of heat budgets from radioactivities for early planetary differentiation. New high-precision multi-collector inductively-coupled plasma mass spectrometry (MC-ICP-MS) measurements of 27Al/ 24Mg ratios and Mg-isotopic compositions of nine whole-rock <span class="hlt">CAIs</span> (six mineralogically characterized fragments and three micro-drilled inclusions) from the CV carbonaceous chondrite, Allende yield a well-defined 26Al- 26Mg fossil isochron with an ( 26Al/ 27Al) 0 of (5.23 ± 0.13) × 10 - 5 . Internal mineral isochrons obtained for three of these <span class="hlt">CAIs</span> ( A44A, AJEF, and A43) are consistent with the whole-rock <span class="hlt">CAI</span> isochron. The mineral isochron of AJEF with ( 26Al/ 27Al) 0 = (4.96 ± 0.25) × 10 - 5 , anchored to our precisely determined absolute 207Pb- 206Pb age of 4567.60 ± 0.36 Ma for the same mineral separates, reinstate the "canonical" ( 26Al/ 27Al) 0 of 5 × 10 - 5 for the early Solar System. The uncertainty in ( 26Al/ 27Al) 0 corresponds to a maximum time span of ± 20 Ka (thousand years), suggesting that the Allende <span class="hlt">CAI</span> formation events were culminated within this time span. Although all Allende <span class="hlt">CAIs</span> studied experienced multistage formation history, including melting and evaporation in the solar nebula and post-crystallization alteration likely on the asteroidal parent body, the 26Al- 26Mg and U-Pb-isotopic systematics of the mineral separates and bulk <span class="hlt">CAIs</span> behaved largely as closed-system since their formation. Our data do not support the "supra-canonical" 26Al/ 27Al ratio of individual minerals or their mixtures in CV <span class="hlt">CAIs</span>, suggesting that the supra-canonical 26Al/ 27Al ratio in the CV <span class="hlt">CAIs</span> may have resulted from post</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015ApSS..328...95J','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015ApSS..328...95J"><span id="translatedtitle">An <span class="hlt">investigation</span> of the electrochemical <span class="hlt">action</span> of the epoxy zinc-rich coatings containing surface modified aluminum nanoparticle</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Jalili, M.; Rostami, M.; Ramezanzadeh, B.</p> <p>2015-02-01</p> <p>Aluminum nanoparticle was modified with amino trimethylene phosphonic acid (ATMP). The surface characterization of the nanoparticles was done by X-ray photo electron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR) and thermal gravimetric analysis. The influence of the replacement of 2 wt% of zinc dust in the standard zinc-rich epoxy coating by nanoparticles on the electrochemical <span class="hlt">action</span> of the coating was studied by electrochemical impedance spectroscopy (EIS) and salt spray tests. The morphology and phase composition of the zinc rich paints were evaluated by X-ray diffraction (XRD) and filed-emission scanning electron microscopy (FE-SEM). Results showed that the ATMP molecules successfully adsorbed on the surface of Al nanoparticles. Results obtained from salt spray and electrochemical measurements revealed that the addition of surface modified nanoparticles to the zinc rich coating enhanced its galvanic <span class="hlt">action</span> and corrosion protection properties.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4287695','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4287695"><span id="translatedtitle">Can the Identity of a Behavior Setting Be Perceived Through Patterns of Joint <span class="hlt">Action</span>? An <span class="hlt">Investigation</span> of Place Perception</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Heft, Harry; Hoch, Justine; Edmunds, Trent; Weeks, Jillian</p> <p>2014-01-01</p> <p>“Behavior settings” are generated by joint <span class="hlt">actions</span> of individuals in conjunction with the milieu features (or affordances) that are available. The reported research explores the hypothesis that the identity or meaning of a behavior setting can be perceived by means of the patterns of <span class="hlt">action</span> collectively generated by the setting’s participants. A set of computer animations was created based on detailed observation of activities in everyday settings. Three experiments were conducted to assess whether perceivers could extract “structure from motion” (in this case, collective <span class="hlt">actions</span>) that was specific to the particular behavior setting displayed by way of the animations. Two experiments assessed whether individuals could accurately perceive the identity of the behavior settings with such displays, and a third experiment indirectly examined this possibility by evaluating whether setting possibilities and constraints were recognized. The results offered some support for the hypothesis, and suggested several refinements in how to conceptualize a typology of behavior settings. An ecological approach to place perception is also discussed. PMID:25431443</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013RSTEd..31..288G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013RSTEd..31..288G"><span id="translatedtitle">Facilitating the learning process in design-based learning practices: an <span class="hlt">investigation</span> of teachers' <span class="hlt">actions</span> in supervising students</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Gómez Puente, S. M.; van Eijck, M.; Jochems, W.</p> <p>2013-11-01</p> <p>Background: In research on design-based learning (DBL), inadequate attention is paid to the role the teacher plays in supervising students in gathering and applying knowledge to design artifacts, systems, and innovative solutions in higher education. Purpose: In this study, we examine whether teacher <span class="hlt">actions</span> we previously identified in the DBL literature as important in facilitating learning processes and student supervision are present in current DBL engineering practices. Sample: The sample (N=16) consisted of teachers and supervisors in two engineering study programs at a university of technology: mechanical and electrical engineering. We selected randomly teachers from freshman and second-year bachelor DBL projects responsible for student supervision and assessment. Design and method: Interviews with teachers, and interviews and observations of supervisors were used to examine how supervision and facilitation <span class="hlt">actions</span> are applied according to the DBL framework. Results: Major findings indicate that formulating questions is the most common practice seen in facilitating learning in open-ended engineering design environments. Furthermore, other DBL <span class="hlt">actions</span> we expected to see based upon the literature were seldom observed in the coaching practices within these two programs. Conclusions: Professionalization of teachers in supervising students need to include methods to scaffold learning by supporting students in reflecting and in providing formative feedback.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3314553','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3314553"><span id="translatedtitle">Differences in anti-malarial activity of 4-aminoalcohol quinoline enantiomers and <span class="hlt">investigation</span> of the presumed underlying mechanism of <span class="hlt">action</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2012-01-01</p> <p>Background A better anti-malarial efficiency and lower neurotoxicity have been reported for mefloquine (MQ) (+)- enantiomer. However, the importance of stereoselectivity remains poorly understood as the anti-malarial activity of pure enantiomer MQ analogues has never been described. Building on these observations, a series of enantiopure 4-aminoalcohol quinoline derivatives has previously been synthesized to optimize the efficiency and reduce possible adverse effects. Their in vitro activity on Plasmodium falciparum W2 and 3D7 strains is reported here along with their inhibition of β-haematin formation and peroxidative degradation of haemin, two possible mechanisms of <span class="hlt">action</span> of anti-malarial drugs. Results The (S)-enantiomers of this series of 4-aminoalcohol quinoline derivatives were found to be at least as effective as both chloroquine (CQ) and MQ. The derivative with a 5-carbon side-chain length was the more efficient on both P. falciparum strains. (R )-enantiomers displayed an activity decreased by 2 to 15-fold as compared to their (S) counterparts. The inhibition of β-haematin formation was significantly stronger with all tested compounds than with MQ, irrespective of the stereochemistry. Similarly, the inhibition of haemin peroxidation was significantly higher for both (S) and (R)-enantiomers of derivatives with a side-chain length of five or six carbons than for MQ and CQ. Conclusions The prominence of stereochemistry in the anti-malarial activity of 4-aminoalcohol quinoline derivatives is confirmed. The inhibition of β-haematin formation and haemin peroxidation can be put forward as presumed mechanisms of <span class="hlt">action</span> but do not account for the stereoselectivity of <span class="hlt">action</span> witnessed in vitro. PMID:22401346</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3712225','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3712225"><span id="translatedtitle">Optic ataxia as a model to <span class="hlt">investigate</span> the role of the posterior parietal cortex in visually guided <span class="hlt">action</span>: evidence from studies of patient M.H.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Cavina-Pratesi, Cristiana; Connolly, Jason D.; Milner, A. David</p> <p>2013-01-01</p> <p>Optic ataxia is a neuropsychological disorder that affects the ability to interact with objects presented in the visual modality following either unilateral or bilateral lesions of the posterior parietal cortex (PPC). Patients with optic ataxia fail to reach accurately for objects, particularly when they are presented in peripheral vision. The present review will focus on a series of experiments performed on patient M.H. Following a lesion restricted largely to the left PPC, he developed mis-reaching behavior when using his contralesional right arm for movements directed toward the contralesional (right) visual half-field. Given the clear-cut specificity of this patient's deficit, whereby reaching <span class="hlt">actions</span> are essentially spared when executed toward his ipsilateral space or when using his left arm, M.H. provides a valuable “experiment of nature” for <span class="hlt">investigating</span> the role of the PPC in performing different visually guided <span class="hlt">actions</span>. In order to address this, we used kinematic measurement techniques to <span class="hlt">investigate</span> M.H.'s reaching and grasping behavior in various tasks. Our experiments support the idea that optic ataxia is highly function-specific: it affects a specific sub-category of visually guided <span class="hlt">actions</span> (reaching but not grasping), regardless of their specific end goal (both reaching toward an object and reaching to avoid an obstacle); and finally, is independent of the limb used to perform the <span class="hlt">action</span> (whether the arm or the leg). Critically, these results are congruent with recent functional MRI experiments in neurologically intact subjects which suggest that the PPC is organized in a function-specific, rather than effector-specific, manner with different sub-portions of its mantle devoted to guiding <span class="hlt">actions</span> according to their specific end-goal (reaching, grasping, or looking), rather than according to the effector used to perform them (leg, arm, hand, or eyes). PMID:23882200</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title29-vol2/pdf/CFR-2010-title29-vol2-sec452-136.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title29-vol2/pdf/CFR-2010-title29-vol2-sec452-136.pdf"><span id="translatedtitle">29 CFR 452.136 - <span class="hlt">Investigation</span> of complaint by Office of Labor-Management Standards, court <span class="hlt">action</span> by the Secretary.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-07-01</p> <p>... 29 Labor 2 2010-07-01 2010-07-01 false <span class="hlt">Investigation</span> of complaint by Office of Labor-Management... Enforcement Provisions § 452.136 <span class="hlt">Investigation</span> of complaint by Office of Labor-Management Standards, court... OF LABOR-MANAGEMENT STANDARDS, DEPARTMENT OF LABOR LABOR-MANAGEMENT STANDARDS GENERAL...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015GeCoA.153..183F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015GeCoA.153..183F"><span id="translatedtitle">Evidence for an early nitrogen isotopic evolution in the solar nebula from volatile analyses of a <span class="hlt">CAI</span> from the CV3 chondrite NWA 8616</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Füri, Evelyn; Chaussidon, Marc; Marty, Bernard</p> <p>2015-03-01</p> <p>Nitrogen and noble gas (Ne-Ar) abundances and isotope ratios, determined by CO2 laser extraction static mass spectrometry analysis, as well as Al-Mg and O isotope data from secondary ion mass spectrometry (SIMS) analyses, are reported for a type B calcium-aluminum-rich inclusion (<span class="hlt">CAI</span>) from the CV3 chondrite NWA 8616. The high (26Al/27Al)i ratio of (5.06 ± 0.50) × 10-5 dates the last melting event of the <span class="hlt">CAI</span> at 39-99+109ka after "time zero", limiting the period during which high-temperature exchanges between the <span class="hlt">CAI</span> and the nebular gas could have occurred to a very short time interval. Partial isotopic exchange with a 16O-poor reservoir resulted in Δ17O > -5‰ for melilite and anorthite, whereas spinel and Al-Ti-pyroxene retain the inferred original 16O-rich signature of the solar nebula (Δ17O ⩽ -20‰). The low 20Ne/22Ne (⩽0.83) and 36Ar/38Ar (⩽0.75) ratios of the <span class="hlt">CAI</span> rule out the presence of any trapped planetary or solar noble gases. Cosmogenic 21Ne and 38Ar abundances are consistent with a cosmic ray exposure (CRE) age of ∼14 to 20 Ma, assuming CR fluxes similar to modern ones, without any evidence for pre-irradiation of the <span class="hlt">CAI</span> before incorporation into the meteorite parent body. Strikingly, the <span class="hlt">CAI</span> contains 1.4-3.4 ppm N with a δ15N value of +8‰ to +30‰. Even after correcting the measured δ15N values for cosmogenic 15N produced in situ, the <span class="hlt">CAI</span> is highly enriched in 15N compared to the protosolar nebula (δ15NPSN = -383 ± 8‰; Marty et al., 2011), implying that the <span class="hlt">CAI</span>-forming region was contaminated by 15N-rich material within the first 0.15 Ma of Solar System history, or, alternatively, that the <span class="hlt">CAI</span> was ejected into the outer Solar System where it interacted with a 15N-rich reservoir.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/8532','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/8532"><span id="translatedtitle">Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan for Corrective <span class="hlt">Action</span> Unit 486: Double Tracks RADSAFE Ares, Nellis Air Force Range, Nevada, Rev. 0; DOE/NV--523 UPDATED WITH ROTC No.1 and 2</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>ITLV</p> <p>1999-11-16</p> <p>This CAIP presents a plan to <span class="hlt">investigate</span> the DTRSA where unregulated disposal of radioactive and possibly hazardous waste occurred during decontamination activities for the Double Tracks test. The purpose of the corrective <span class="hlt">action</span> <span class="hlt">investigation</span> described in this CAIP is to: Identify and verify the locations of the decontamination facility and animal burial pit within the DTRSA; Identify the presence and nature of COPCs; Determine the vertical and lateral extent of COPCs; and Provide sufficient information and data to develop and evaluate appropriate corrective <span class="hlt">actions</span> for the CAS. This CAIP was developed using the U.S. Environmental Protection Agency (EPA) Data Quality Objectives (DQOs) (EPA, 1994d) process to clearly define the goals for collecting environmental data, to determine data uses, and to design a data collection program that will satisfy these uses. A DQO scoping meeting was held prior to preparation of this plan; a brief summary of the DQOs is presented in Section 3.4. A more detailed summary of the DQO process and results is included in Appendix A.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014M%26PS...49..812F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014M%26PS...49..812F"><span id="translatedtitle">Hydrothermal origin of hexagonal CaAl2Si2O8 (dmisteinbergite) in a compact type A <span class="hlt">CAI</span> from the Northwest Africa 2086 CV3 chondrite</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Fintor, Krisztian; Park, Changkun; Nagy, Szabolcs; Pál-Molnár, Elemér; Krot, Alexander N.</p> <p>2014-05-01</p> <p>We report an occurrence of hexagonal CaAl2Si2O8 (dmisteinbergite) in a compact type A calcium-aluminum-rich inclusion (<span class="hlt">CAI</span>) from the CV3 (Vigarano-like) carbonaceous chondrite Northwest Africa 2086. Dmisteinbergite occurs as approximately 10 μm long and few micrometer-thick lath-shaped crystal aggregates in altered parts of the <span class="hlt">CAI</span>, and is associated with secondary nepheline, sodalite, Ti-poor Al-diopside, grossular, and Fe-rich spinel. Spinel is the only primary <span class="hlt">CAI</span> mineral that retained its original O-isotope composition (Δ17O ~ -24‰); Δ17O values of melilite, perovskite, and Al,Ti-diopside range from -3 to -11‰, suggesting postcrystallization isotope exchange. Dmisteinbergite, anorthite, Ti-poor Al-diopside, and ferroan olivine have 16O-poor compositions (Δ17O ~ -3‰). We infer that dmisteinbergite, together with the other secondary minerals, formed by replacement of melilite as a result of fluid-assisted thermal metamorphism experienced by the CV chondrite parent asteroid. Based on the textural appearance of dmisteinbergite in NWA 2086 and petrographic observations of altered <span class="hlt">CAIs</span> from the Allende meteorite, we suggest that dmisteinbergite is a common secondary mineral in <span class="hlt">CAIs</span> from the oxidized Allende-like CV3 chondrites that has been previously misidentified as a secondary anorthite.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4503980','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4503980"><span id="translatedtitle">Biochemical <span class="hlt">investigations</span> of the mechanism of <span class="hlt">action</span> of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Bach, Anders; Pedersen, Søren W.; Dorr, Liam A.; Vallon, Gary; Ripoche, Isabelle; Ducki, Sylvie; Lian, Lu-Yun</p> <p>2015-01-01</p> <p>ZL006 and IC87201 have been presented as efficient inhibitors of the nNOS/PSD-95 protein-protein interaction and shown great promise in cellular experiments and animal models of ischemic stroke and pain. Here, we <span class="hlt">investigate</span> the proposed mechanism of <span class="hlt">action</span> of ZL006 and IC87201 using biochemical and biophysical methods, such as fluorescence polarization (FP), isothermal titration calorimetry (ITC), and 1H-15N HSQC NMR. Our data show that under the applied in vitro conditions, ZL006 and IC87201 do not interact with the PDZ domains of nNOS or PSD-95, nor inhibit the nNOS-PDZ/PSD-95-PDZ interface by interacting with the β-finger of nNOS-PDZ. Our findings have implications for further medicinal chemistry efforts of ZL006, IC87201 and analogues, and challenge the general and widespread view on their mechanism of <span class="hlt">action</span>. PMID:26177569</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24666130','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24666130"><span id="translatedtitle">Moving mirrors: a high-density EEG study <span class="hlt">investigating</span> the effect of camera movements on motor cortex activation during <span class="hlt">action</span> observation.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Heimann, Katrin; Umiltà, Maria Alessandra; Guerra, Michele; Gallese, Vittorio</p> <p>2014-09-01</p> <p><span class="hlt">Action</span> execution-perception links (mirror mechanism) have been repeatedly suggested to play crucial roles in social cognition. Remarkably, the designs of most studies exploring this topic so far excluded even the simplest traces of social interaction, such as a movement of the observer toward another individual. This study introduces a new design by <span class="hlt">investigating</span> the effects of camera movements, possibly simulating the observer's own approaching movement toward the scene. We conducted a combined high-density EEG and behavioral study <span class="hlt">investigating</span> motor cortex activation during <span class="hlt">action</span> observation measured by event-related desynchronization and resynchronization (ERD/ERS) of the mu rhythm. Stimuli were videos showing a goal-related hand <span class="hlt">action</span> filmed while using the camera in four different ways: filming from a fixed position, zooming in on the scene, approaching the scene by means of a dolly, and approaching the scene by means of a steadycam. Results demonstrated a consistently stronger ERD of the mu rhythm for videos that were filmed while approaching the scene with a steadycam. Furthermore, videos in which the zoom was applied reliably demonstrated a stronger rebound. A rating task showed that videos in which the camera approached the scene were felt as more involving and the steadycam was most able to produce a visual experience close to the one of a human approaching the scene. These results suggest that filming technique predicts time course specifics of ERD/ERS during <span class="hlt">action</span> observation with only videos simulating the natural vision of a walking human observer eliciting a stronger ERD than videos filmed from a fixed position. This demonstrates the utility of ecologically designed studies for exploring social cognition. PMID:24666130</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/6237802','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/6237802"><span id="translatedtitle"><span class="hlt">Investigation</span> of molecular mechanisms in photodynamic <span class="hlt">action</span> and radiobiology with nanosecond flash photolysis and pulse radiolysis. Progress report, 1982</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Grossweiner, L.I.</p> <p>1983-01-01</p> <p>Liposomes have been employed as membrane models applicable to photosensitization in phototherapy procedures. The results with 8-methoxypsoralen, the sensitizer in PUVA therapy of psoriasis, show that singlet oxygen generated by near-uv (uv-A) irradiation induces membrane damage leading to lysis. A similar role of singlet oxygen has been shown for photosensitization of liposomes by methylene blue, with the new observation that hydrodynamic forces promote the lytic <span class="hlt">action</span> initiated by singlet oxygen attack on an unsaturated site of phosphatidylcholine. Liposome photosensitization by hematoporphyrin follows a Type II mechanism mediated by singlet oxygen for low sensitizer concentrations, and a Type I, anoxic, mechanism when the hematoporphyrin is aggregated. Similar concentration effects obtain with hematoporphyrin derivative (hpd), the photosensitizer in photoradiation therapy of malignant tumors. Studies on the components of hpd separated by gel chromatography show that the putative biological active fraction can photosensitize membrane damage under oxic and anoxic conditions. The oxic pathway was suppressed by binding to human serum albumin, as involved in serum transport of hpd prior to localization in tumor tissue. A study on hematoporphyrin photosensitization of targets other than membranes has shown that singlet oxygen is responsible for the photosensitized inactivation of subtilisin BPN' and photooxidation of tryptophan in human and bovine serum albumin. In the case of the serum proteins, the singlet oxygen is generated by the sensitizer-protein complex and it may react with all protein in the system. 11 references.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/9536540','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/9536540"><span id="translatedtitle"><span class="hlt">Investigation</span> of the mechanism of <span class="hlt">action</span> of 2% fusidic acid lotion in the treatment of acne vulgaris.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sommer, S; Bojar, R; Cunliffe, W J; Holland, D; Holland, K T; Naags, H</p> <p>1997-09-01</p> <p>We describe the results of a single-centre, double-blind, vehicle-controlled, parallel group study on the quantitative effects of 2% fusidic acid lotion (Fucidin lotion) in facial acne vulgaris. The trial was completed by 52 patients aged 15-25 years with mild to moderate acne who had been randomized to either Fucidin Lotion (n = 25) or its base (n = 27). Primary outcome measures included colony counts of Propionibacterium acnes and micrococcaceae and measurements of skin surface lipid free fatty acids and sebum excretion rate. Clinical assessment was based on the acne grade, count of inflamed and non-inflamed lesions and evidence of a primary irritant dermatitis. There was a variable but gradual reduction in lesion counts with the maximum improvement at 12 weeks for inflamed lesions, where the reduction was 19.9% for fusidic acid and 24.7% for the placebo. The non-inflamed lesions decreased by 10.8% in the fusidic acid group and increased by 15.9% in the placebo group; this difference was not statistically significant. Although the fusidic acid reduced the micrococcaceae count by 1 log cycle, inferring adequate compliance, there was no reduction in the counts of P. acnes, surface free fatty acids or sebum excretion rate. This study has failed to explain the mechanism of <span class="hlt">action</span> of topical fusidic acid.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27534387','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27534387"><span id="translatedtitle"><span class="hlt">Investigation</span> of gender differences in the cardiovascular <span class="hlt">actions</span> of direct and indirect sympathomimetic stimulants including cathinone in the anaesthetized rat.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Alsufyani, H A; Docherty, J R</p> <p>2016-01-01</p> <p>We have studied gender differences in the direct and indirect sympathomimetic cardiovascular effects of the stimulant cathinone (from Khat) (and for comparison methylenedioxymethamphetamine [MDMA]) and the archetypal indirect sympathomimetic agent tyramine, employing male and female Wistar rats. Animals were sympathectomized by treatment with 6-hydroxydopamine or treated with vehicle. In male and female vehicle-treated pentobarbitone-anaesthetized rats, all three agonists (0.001-1 mg/kg) produced significant tachycardia, tyramine produced large pressor, and in high doses small depressor responses, MDMA produced small pressor responses, and cathinone produced only minor pressor effects. In sympathectomized rats, pressor responses, even those to tyramine, were virtually abolished, and depressor responses to tyramine were abolished. In vehicle-treated rats, the tachycardia to tyramine, but not the tachycardia to cathinone or MDMA, was significantly greater in male than female rats. This may suggest that the mechanism of the tachycardia to tyramine differs from those of the stimulants cathinone and MDMA. Following sympathectomy, there were no differences between male and female rats in the tachycardia to any agent. Hence, there were gender differences in the tachycardia response for tyramine, but no gender differences in the cardiovascular responses to the widely used recreational stimulants cathinone and MDMA. Cardiac stimulant <span class="hlt">actions</span> of cathinone and MDMA were similar in male and female rats. PMID:27534387</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/859336','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/859336"><span id="translatedtitle">Corrective <span class="hlt">Action</span> Decision Document/Closure Report for Corrective <span class="hlt">Action</span> Unit 554: Area 23 Release Site Nevada Test Site, Nevada, Revision 0</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Evenson, Grant</p> <p>2005-07-01</p> <p>This Corrective <span class="hlt">Action</span> Decision Document/Closure Report has been prepared for Corrective <span class="hlt">Action</span> Unit 554, Area 23 Release Site, located in Mercury at the Nevada Test Site, Nevada, in accordance with the ''Federal Facility Agreement and Consent Order'' (1996). Corrective <span class="hlt">Action</span> Unit (CAU) 554 is comprised of one corrective <span class="hlt">action</span> site (CAS): (1) CAS 23-02-08, USTs 23-115-1, 2, 3/Spill 530-90-002. The purpose of this Corrective <span class="hlt">Action</span> Decision Document/Closure Report is to provide justification and documentation supporting the recommendation for closure of CAU 554 with no further corrective <span class="hlt">action</span>. To achieve this, corrective <span class="hlt">action</span> <span class="hlt">investigation</span> (<span class="hlt">CAI</span>) activities were performed from January 18 through May 5, 2005, as set forth in the ''Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan for Corrective <span class="hlt">Action</span> Unit 554: Area 23 Release Site'' (NNSA/NSO, 2004) and Records of Technical Change No. 1 and No. 2. The purpose of the <span class="hlt">CAI</span> was to fulfill the following data needs as defined during the data quality objective (DQO) process: (1) Determine whether contaminants of concern are present. (2) If contaminants of concern are present, determine their nature and extent. (3) Provide sufficient information and data to complete appropriate corrective <span class="hlt">actions</span>. The CAU 554 dataset from the <span class="hlt">investigation</span> results was evaluated based on the data quality indicator parameters. This evaluation demonstrated the quality and acceptability of the dataset for use in fulfilling the DQO data needs. Analytes detected during the <span class="hlt">CAI</span> were evaluated against preliminary <span class="hlt">action</span> levels (PALs) established in the CAU 554 CAIP for total petroleum hydrocarbons (TPH) benzo(a)pyrene, dibenz(a,h)anthracene, and trichloroethene (TCE). Specifically: (1) The soil beneath and laterally outward from former underground storage tanks at CAS 23-02-08 contains TPH-diesel-range organics (DRO) above the PAL of 100 milligrams per kilogram, confined vertically from a depth of approximately 400 feet (ft) below ground surface (bgs). The</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/897669','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/897669"><span id="translatedtitle">Corrective <span class="hlt">Action</span> Decision Document for Corrective <span class="hlt">Action</span> Unit 168: Area 25 and 26 Contaminated Materials and Waste Dumps, Nevada Test Site, Nevada, Rev. No.: 2 with Errata Sheet</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Wickline, Alfred</p> <p>2006-12-01</p> <p>This Corrective <span class="hlt">Action</span> Decision Document has been prepared for Corrective <span class="hlt">Action</span> Unit (CAU) 168: Area 25 and 26, Contaminated Materials and Waste Dumps, Nevada Test Site, Nevada. The purpose of this Corrective <span class="hlt">Action</span> Decision Document is to identify and provide a rationale for the selection of a recommended corrective <span class="hlt">action</span> alternative for each corrective <span class="hlt">action</span> site (CAS) within CAU 168. The corrective <span class="hlt">action</span> <span class="hlt">investigation</span> (<span class="hlt">CAI</span>) was conducted in accordance with the ''Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> Plan for Corrective <span class="hlt">Action</span> Unit 168: Area 25 and 26, Contaminated Materials and Waste Dumps, Nevada Test Site, Nevada'', as developed under the ''Federal Facility Agreement and Consent Order'' (1996). Corrective <span class="hlt">Action</span> Unit 168 is located in Areas 25 and 26 of the Nevada Test Site, Nevada and is comprised of the following 12 CASs: CAS 25-16-01, Construction Waste Pile; CAS 25-16-03, MX Construction Landfill; CAS 25-19-02, Waste Disposal Site; CAS 25-23-02, Radioactive Storage RR Cars; CAS 25-23-13, ETL - Lab Radioactive Contamination; CAS 25-23-18, Radioactive Material Storage; CAS 25-34-01, NRDS Contaminated Bunker; CAS 25-34-02, NRDS Contaminated Bunker; CAS 25-99-16, USW G3; CAS 26-08-01, Waste Dump/Burn Pit; CAS 26-17-01, Pluto Waste Holding Area; and CAS 26-19-02, Contaminated Waste Dump No.2. Analytes detected during the <span class="hlt">CAI</span> were evaluated against preliminary <span class="hlt">action</span> levels (PALs) to determine contaminants of concern (COCs) for CASs within CAU 168. Radiological measurements of railroad cars and test equipment were compared to unrestricted (free) release criteria. Assessment of the data generated from the <span class="hlt">CAI</span> activities revealed the following: (1) Corrective <span class="hlt">Action</span> Site 25-16-01 contains hydrocarbon-contaminated soil at concentrations exceeding the PAL. The contamination is at discrete locations associated with asphalt debris. (2) No COCs were identified at CAS 25-16-03. Buried construction waste is present in at least two disposal cells contained within the</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=relative+AND+density&pg=6&id=ED521258','ERIC'); return false;" href="http://eric.ed.gov/?q=relative+AND+density&pg=6&id=ED521258"><span id="translatedtitle">Using Discrepant Events in Science Demonstrations to Promote Student Engagement in Scientific <span class="hlt">Investigations</span>: An <span class="hlt">Action</span> Research Study</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Mancuso, Vincent J.</p> <p>2010-01-01</p> <p>Students' scientific <span class="hlt">investigations</span> have been identified in national standards and related reform documents as a critical component of students' learning experiences in school, yet it is not easy to implement them in science classrooms. Could science demonstrations help science teachers put this recommendation into practice? While demonstrations…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://pubs.usgs.gov/of/2002/of02-302/','USGSPUBS'); return false;" href="https://pubs.usgs.gov/of/2002/of02-302/"><span id="translatedtitle">Thermal maturity patterns (<span class="hlt">CAI</span> and %R) in the Ordovician and Devonian rocks of the Appalachian basin in Pennsylvania</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Repetski, John E.; Ryder, Robert T.; Harper, John A.; Trippi, Michael H.</p> <p>2002-01-01</p> <p>The objective of this study is to enhance existing thermal maturity maps in Pennsylvania by establishing: 1) new subsurface <span class="hlt">CAI</span> data points for the Ordovician and Devonian and 2) new %Ro and Rock Eval subsurface data points for Middle and Upper Devonian black shale units. Thermal maturity values for the Ordovician and Devonian strata are of major interest because they contain the source rocks for most of the oil and natural gas resources in the basin. Thermal maturity patterns of the Middle Ordovician Trenton Group are evaluated here because they closely approximate those of the overlying Ordovician Utica Shale that is believed to be the source rock for the regional oil and gas accumulation in Lower Silurian sandstones (Ryder and others, 1998) and for natural gas fields in fractured dolomite reservoirs of the Ordovician Black River-Trenton Limestones. Improved <span class="hlt">CAI</span>-based thermal maturity maps of the Ordovician are important to identify areas of optimum gas generation from the Utica Shale and to provide constraints for interpreting the origin of oil and gas in the Lower Silurian regional accumulation and Ordovician Black River-Trenton fields. Thermal maturity maps of the Devonian will better constrain burial history-petroleum generation models of the Utica Shale, as well as place limitations on the origin of regional oil and gas accumulations in Upper Devonian sandstone and Middle to Upper Devonian black shale.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://pubs.er.usgs.gov/publication/70028484','USGSPUBS'); return false;" href="http://pubs.er.usgs.gov/publication/70028484"><span id="translatedtitle">Thermal maturity patterns in the Ordovician and Devonian of Pennsylvania using conodont color alteration index (<span class="hlt">CAI</span>) and vitrinite reflectance (%Ro)</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Repetski, J.E.; Ryder, R.T.; Harper, J.A.; Trippi, M.H.</p> <p>2006-01-01</p> <p>This new series of maps enhances previous thermal maturity maps in Pennsylvania by establishing: 1) new subsurface <span class="hlt">CAI</span> data points for the Ordovician and Devonian and 2) new %Ro and Rock Eval subsurface data points for Middle and Upper Devonian black shale units. Thermal maturity values for the Ordovician and Devonian strata are of major interest because they contain the source rocks for most of the oil and natural gas resources in the basin. Thermal maturity patterns of the Middle Ordovician Trenton Group are evaluated here because they closely approximate those of the overlying Ordovician Utica Shale that is believed to be the source rock for the regional oil and gas accumulation in Lower Silurian sandstones and for natural gas fields in fractured dolomite reservoirs of the Ordovician Black River-Trenton Limestones. Improved <span class="hlt">CAI</span>-based thermal maturity maps of the Ordovician are important to identify areas of optimum gas generation from the Utica Shale and to provide constraints for interpreting the origin of oil and gas in the Lower Silurian regional accumulation and Ordovician Black River-Trenton fields. Thermal maturity maps of the Devonian will better constrain burial history-petroleum generation models of the Utica Shale, as well as place limitations on the origin of regional oil and gas accumulations in Upper Devonian sandstone and Middle to Upper Devonian black shale.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_22 --> <div id="page_23" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="441"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21633079','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21633079"><span id="translatedtitle">In dialyzed squid axons oxidative stress inhibits the Na+/Ca2+ exchanger by impairing the <span class="hlt">Cai</span>2+-regulatory site.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>DiPolo, Reinaldo; Beaugé, Luis</p> <p>2011-09-01</p> <p>The Na(+)/Ca(2+) exchanger, a major mechanism by which cells extrude calcium, is involved in several physiological and physiopathological interactions. In this work we have used the dialyzed squid giant axon to study the effects of two oxidants, SIN-1-buffered peroxynitrite and hydrogen peroxide (H(2)O(2)), on the Na(+)/Ca(2+) exchanger in the absence and presence of MgATP upregulation. The results show that oxidative stress induced by peroxynitrite and hydrogen peroxide inhibits the Na(+)/Ca(2+) exchanger by impairing the intracellular Ca(2+) (<span class="hlt">Ca(i</span>)(2+))-regulatory sites, leaving unharmed the intracellular Na(+)- and Ca(2+)-transporting sites. This effect is efficiently counteracted by the presence of MgATP and by intracellular alkalinization, conditions that also protect H(i)(+) and (H(i)(+) + Na(i)(+)) inhibition of <span class="hlt">Ca(i</span>)(2+)-regulatory sites. In addition, 1 mM intracellular EGTA reduces oxidant inhibition. However, once the effects of oxidants are installed they cannot be reversed by either MgATP or EGTA. These results have significant implications regarding the role of the Na(+)/Ca(2+) exchanger in response to pathological conditions leading to tissue ischemia-reperfusion and anoxia/reoxygenation; they concur with a marked reduction in ATP concentration, an increase in oxidant production, and a rise in intracellular Ca(2+) concentration that seems to be the main factor responsible for cell damage.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014MS%26E...64a2009N','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014MS%26E...64a2009N"><span id="translatedtitle">Compression-after-impact (<span class="hlt">CAI</span>) performance of epoxycarbon fibre-reinforced nanocomposites using nanosilica and rubber particle enhancement</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Nikfar, B.; Njuguna, J.</p> <p>2014-08-01</p> <p>One of the problems in the design of automotive structures and body parts made by fibre reinforced composites is that these materials are susceptible to a small energy impact caused by for instance, accidental tool drop during maintenance or stone strike while in operation. This often lead to a barely visible impact damage which causes reduction in compressive strength of the composite part. To increase the impact tolerance of the composites, toughening agents like silica nanoparticles and rubber particles can be utilized to toughen the resin. To understand the effect of the particles enhancement, the impact tolerance was evaluated utilizing Compression After Impact (<span class="hlt">CAI</span>) test after the impact induced by gas- gun impacting equipment. The results from <span class="hlt">CAI</span> test after 20 J impact (high energy stone strike) shows about 30% improvement in residual compressive strength for the nanosilica enhanced composite compared to unmodified CFRP. Also C-scan results after 7 J impact shows about 50% smaller delamination area for the nano-enhanced composite.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://pubs.usgs.gov/of/2005/1078/','USGSPUBS'); return false;" href="https://pubs.usgs.gov/of/2005/1078/"><span id="translatedtitle">Thermal maturity patterns (<span class="hlt">CAI</span> and %Ro) in the Ordovician and Devonian rocks of the Appalachian basin in West Virginia</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Repetski, John E.; Ryder, Robert T.; Avary, Katharine Lee; Trippi, Michael H.</p> <p>2005-01-01</p> <p>The objective of this study is to enhance existing thermal maturity maps in West Virginia by establishing: 1) new subsurface <span class="hlt">CAI</span> data points for the Ordovician and Devonian and 2) new %Ro and Rock Eval subsurface data points for Middle and Upper Devonian black shale units. Thermal maturity values for the Ordovician and Devonian strata are of major interest because they contain the source rocks for most of the oil and natural gas resources in the basin. Thermal maturity patterns of the Middle Ordovician Trenton Limestone are evaluated here because they closely approximate those of the overlying Ordovician Utica Shale that is believed to be the source rock for the regional oil and gas accumulation in Lower Silurian sandstones (Ryder and others, 1998) and for natural gas fields in fractured dolomite reservoirs of the Ordovician Black River-Trenton Limestones. Improved <span class="hlt">CAI</span>-based thermal maturity maps of the Ordovician are important to identify areas of optimum gas generation from the Utica Shale and to provide constraints for interpreting the origin of oil and gas in the Lower Silurian regional accumulation and Ordovician Black River-Trenton fields. Thermal maturity maps of the Devonian will better constrain burial history-petroleum generation models of the Utica Shale, as well as place limitations on the origin of regional oil and gas accumulations in Upper Devonian sandstone and Middle to Upper Devonian black shale.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26982820','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26982820"><span id="translatedtitle">Mechanism of <span class="hlt">Action</span> of Thymol on Cell Membranes <span class="hlt">Investigated</span> through Lipid Langmuir Monolayers at the Air-Water Interface and Molecular Simulation.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ferreira, João Victor N; Capello, Tabata M; Siqueira, Leonardo J A; Lago, João Henrique G; Caseli, Luciano</p> <p>2016-04-01</p> <p>A major challenge in the design of biocidal drugs is to identify compounds with potential <span class="hlt">action</span> on microorganisms and to understand at the molecular level their mechanism of <span class="hlt">action</span>. In this study, thymol, a monoterpenoid found in the oil of leaves of Lippia sidoides with possible <span class="hlt">action</span> in biological surfaces, was incorporated in lipid monolayers at the air-water interface that represented cell membrane models. The interaction of thymol with dipalmitoylphosphatidylcholine (DPPC) at the air-water interface was <span class="hlt">investigated</span> by means of surface pressure-area isotherms, Brewster angle microscopy (BAM), polarization-modulation reflection-absorption spectroscopy (PM-IRRAS), and molecular dynamics simulation. Thymol expands DPPC monolayers, decreases their surface elasticity, and changes the morphology of the lipid monolayer, which evidence the incorporation of this compound in the lipid Langmuir film. Such incorporation could be corroborated by PM-IRRAS since some specific bands for DPPC were changed upon thymol incorporation. Furthermore, potential of mean force obtained by molecular dynamics simulations indicates that the most stable position of the drug along the lipid film is near the hydrophobic regions of DPPC. These results may be useful to understand the interaction between thymol and cell membranes during biochemical phenomena, which may be associated with its pharmaceutical properties at the molecular level.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3933468','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3933468"><span id="translatedtitle">Ethical considerations related to participation and partnership: an <span class="hlt">investigation</span> of stakeholders’ perceptions of an <span class="hlt">action</span>-research project on user fee removal for the poorest in Burkina Faso</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2014-01-01</p> <p>Background Healthcare user fees present an important barrier for accessing services for the poorest (indigents) in Burkina Faso and selective removal of fees has been incorporated in national healthcare planning. However, establishing fair, effective and sustainable mechanisms for the removal of user fees presents important challenges. A participatory <span class="hlt">action</span>-research project was conducted in Ouargaye, Burkina Faso, to test mechanisms for identifying those who are indigents, and funding and implementing user fee removal. In this paper, we explore stakeholder perceptions of ethical considerations relating to participation and partnership arising in the <span class="hlt">action</span>-research. Methods We conducted 39 in-depth interviews to examine ethical issues associated with the <span class="hlt">action</span>-research. Respondents included 14 individuals identified as indigent through the community selection process, seven members of village selection committees, six local healthcare professionals, five members of the management committees of local health clinics, five members of the research team, and four regional or national policy-makers. Using constant comparative techniques, we carried out an inductive thematic analysis of the collected data. Results The Ouargaye project involved a participatory model, included both implementation and research components, and focused on a vulnerable group within small, rural communities. Stakeholder perceptions and experiences relating to the participatory approach and reliance on multiple partnerships in the project were associated with a range of ethical considerations related to 1) seeking common ground through communication and collaboration, 2) community participation and risk of stigmatization, 3) impacts of local funding of the user fee removal, 4) efforts to promote fairness in the selection of the indigents, and 5) power relations and the development of partnerships. Conclusions This <span class="hlt">investigation</span> of the Ouargaye project serves to illuminate the distinctive</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27268752','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27268752"><span id="translatedtitle">Active Components of Essential Oils as Anti-Obesity Potential Drugs <span class="hlt">Investigated</span> by in Silico Techniques.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Costa, Giosuè; Gidaro, Maria Concetta; Vullo, Daniela; Supuran, Claudiu T; Alcaro, Stefano</p> <p>2016-07-01</p> <p>In this study, for the first time, we have considered essential oils (EOs) as possible resources of carbonic anhydrase inhibitors (<span class="hlt">CAIs</span>), in particular against the mitochondrial isoform VA that, actually, represents an innovative target for the obesity treatment. In silico structure-based virtual screening was performed in order to speed up the identification of promising antiobesity agents. The potential hit compounds were submitted to in vitro assays and experimental results, corroborated by molecular modeling studies, showed EOs components as a new class of <span class="hlt">CAIs</span> with a competitive mechanism of <span class="hlt">action</span> due to the zinc ion coordination within the active sites of these metallo-enzymes. PMID:27268752</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2005SPIE.5775..622P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2005SPIE.5775..622P"><span id="translatedtitle"><span class="hlt">Investigations</span> of refraction properties of metalphthalocyanie nanostructures after NO2 <span class="hlt">action</span> by means of plasmon resonance method</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Pustelny, Tadeusz; Ignac-Nowicka, Jolanata; Opilski, Zbigniew</p> <p>2005-02-01</p> <p>The paper deals with <span class="hlt">investigations</span> concerning the optical parameters of the layers of selected phthalocyanines by means of the surface plasmon resonance method. The values of the refracting index and the coefficient of extinction for copper and lead phthalocyanines have been determined. The presented results concern the layers occurring in the surrounding atmospheric air before and after exposure to 100 ppm nitrogen dioxide. The obtained dispersive characteristics were determined ellipsometrically and using the surface plasmon resonance method, by adapting theoretical relations to the experimental dependence of the surface plasmon resonance. The resulting values of the complex refracting index for the tested phthalocyanines were compared with the values obtained by ellipsometric measurements.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4138890','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4138890"><span id="translatedtitle">Gastroprotective Activity of Violacein Isolated from Chromobacterium violaceum on Indomethacin-Induced Gastric Lesions in Rats: <span class="hlt">Investigation</span> of Potential Mechanisms of <span class="hlt">Action</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Antonisamy, Paulrayer; Kannan, Ponnusamy; Aravinthan, Adithan; Duraipandiyan, Veeramuthu; Valan Arasu, Mariadhas; Ignacimuthu, Savarimuthu; Abdullah Al-Dhabi, Naif; Kim, Jong-Hoon</p> <p>2014-01-01</p> <p>Chromobacterium violaceum, Gram-negative bacteria species found in tropical regions of the world, produces a distinct deep violet-colored pigment called violacein. In the present study, we <span class="hlt">investigated</span> whether violacein can promote a gastroprotective effect and verified the possible mechanisms involved in this <span class="hlt">action</span>. For this study, an indomethacin-induced gastric ulcer rat model was used. The roles of biomolecules such as MPO, PGE2, pro- and anti-inflammatory cytokines, growth factors, caspase-3, NO, K+ATP channels, and α2-receptors were <span class="hlt">investigated</span>. Violacein exhibited significant gastroprotective effect against indomethacin-induced lesions, while pretreatment with L-NAME and glibenclamide (but not with NEM or yohimbine) was able to reverse this <span class="hlt">action</span>. Pretreatment with violacein also restored cNOS level to normal and led to attenuation of enhanced apoptosis and gastric microvascular permeability. Our results suggest that violacein provides a significant gastroprotective effect in an indomethacin-induced ulcer model through the maintenance of some vital protein molecules, and this effect appears to be mediated, at least in part, by endogenous prostaglandins, NOS, K+ATP channel opening, and inhibition of apoptosis and gastric microvascular permeability. PMID:25162059</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED115225.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED115225.pdf"><span id="translatedtitle">Evaluation of the Experimental <span class="hlt">CAI</span> Network (1973-1975) of the Lister Hill National Center for Biomedical Communications, National Library of Medicine. Final Report. No. ED-75-1.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Rubin, Martin L.; And Others</p> <p></p> <p>An evaluation was made of the biomedical Computer Assisted Instruction (<span class="hlt">CAI</span>) Network Experiment, established by the National Library of Medicine in 1973 to test the feasibility of sharing <span class="hlt">CAI</span> learning materials through a national computer network. The evaluation was designed to assist decision makers in planning a future mechanism for distributing…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013RuPhJ..56..681S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013RuPhJ..56..681S"><span id="translatedtitle"><span class="hlt">Investigation</span> of the process of ferrite formation in the Li2CO3-ZnO-Fe2O3 system under high-energy <span class="hlt">actions</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Surzhikov, A. P.; Lysenko, E. N.; Vlasov, V. A.; Malyshev, A. V.; Nikolaev, E. V.</p> <p>2013-11-01</p> <p>Results of synthesis of lithium-zinc ferrites under high-energy <span class="hlt">actions</span> including mechanical activation of the mixture of initial reagents in a planetary mill and heating of reaction mixtures upon exposure to accelerated high-energy electron beams are presented. The initial structure of the reaction mixtures corresponds to the stoichiometric spinel formula: Li0.5(1- x)Zn x Fe2.5-0.5 x О4, where х = 0.2. To elucidate the effect of radiation on kinetic transformations of the phase composition, analogous <span class="hlt">investigations</span> are performed with thermal annealing in a furnace. It is established that mechanical activation and radiation-thermal heating of the Li2CO3-ZnO-Fe2O3 mixture of initial reagents increases significantly the reactivity of solid phase systems thereby decreasing strongly the temperature of synthesis and improving the homogeneity of the end product. To synthesize Li0.4Fe2.4Zn0.2O4 lithium-zinc ferrospinels with homogeneous composition, it is suffice to provide a synthesis temperature of 600°С with holding time of 60 min under complex high-energy <span class="hlt">action</span> including mechanical activation of the initial mixture of reagents and heating upon exposure to a high-energy beam of electrons.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2006GeCoA..70.2622M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2006GeCoA..70.2622M"><span id="translatedtitle">Crystallization of melilite from CMAS-liquids and the formation of the melilite mantle of Type B1 <span class="hlt">CAIs</span>: Experimental simulations</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Mendybaev, Ruslan A.; Richter, Frank M.; Davis, Andrew M.</p> <p>2006-05-01</p> <p>Type B <span class="hlt">CAIs</span> are subdivided into B1s, with well-developed melilite mantles, and B2s, with randomly distributed melilite. Despite intensive study, the origin of the characteristic melilite mantle of the B1s remains unclear. Recently, we proposed that formation of the melilite mantle is caused by depletion of the droplet surface in volatile magnesium and silicon due to higher evaporation rates of volatile species compared to their slow diffusion rates in the melt, thus making possible crystallization of melilite at the edge of the <span class="hlt">CAI</span> first, followed by its crystallization in the central parts at lower temperatures. Here, we present the results of an experimental study that aimed to reproduce the texture observed in natural Type B <span class="hlt">CAIs</span>. First, we experimentally determined crystallization temperatures of melilite for three melt compositions, which, combined with literature data, allowed us to find a simple relationship between the melt composition, crystallization temperature, and composition of first crystallizing melilite. Second, we conducted a series of evaporation and cooling experiments exposing <span class="hlt">CAI</span>-like melts to gas mixtures with different oxygen fugacities (f). Cooling of the molten droplets in gases with logf⩾IW-4 resulted in crystallization of randomly distributed melilite, while under more reducing conditions, melilite mantles have been formed. Chemical profiles through samples quenched right before melilite started to crystallize showed no chemical gradients in samples exposed to relatively oxidizing gases (logf⩾IW-4), while the near-surface parts of the samples exposed to very reducing gases (logf⩽IW-7) were depleted in volatile MgO and SiO 2, and enriched in refractory Al 2O 3. Using these experimental results and the fact that the evaporation rate of magnesium and silicon from <span class="hlt">CAI</span>-like melts is proportional to √{P}, we estimate that Type B1 <span class="hlt">CAIs</span> could be formed by evaporation of a partially molten precursor in a gas of solar composition with P</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2003EAEJA.....9292C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2003EAEJA.....9292C"><span id="translatedtitle">B and Mg isotopic variations in Leoville mrs-06 type B1 <span class="hlt">cai</span>:origin of 10Be and 26Al</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Chaussidon, M.; Robert, F.; Russel, S. S.; Gounelle, M.; Ash, R. D.</p> <p>2003-04-01</p> <p>The finding [1-3] in Ca-Al-rich refractory inclusions (<span class="hlt">CAI</span>) of primitive chondrites of traces of the in situ decay of radioactive 10Be (half-life 1.5Myr) indicates that irradiation of the protosolar nebula by the young Sun in its T-Tauri phase has produced significant amounts of the Li-Be-B elements. This irradiation may have produced also some or all of the short-lived 26Al (half-life 0.7Myr) and 41Ca (half-life 0.1Myr) previously detected in <span class="hlt">CAIs</span>. To constrain the origin of 10Be and 10Al it is important to look for coupled variations in the 10Be/9Be and 26Al/27Al ratios in <span class="hlt">CAIs</span> and to understand the processes responsible for these variations (e.g. variations in the fluences of irradiation, secondary perturbations of the <span class="hlt">CAIs</span>, ...) We have thus studied the Li and B isotopic compositions and the Be/Li and Be/B concentration ratios in one <span class="hlt">CAI</span> (MRS-06) from the Leoville CV3 chondrite in which large variations of the Mg isotopic compositions showing both the in situ decay of 26Al and the secondary redistribution of Mg isotopes have been observed [4]. The results show large variations for the Li and B isotopic compositions (^7Li/^6Li ranging from 11.02±0.21 to 11.82±0.07, and 10B/11B ratios ranging from 0.2457±0.0053 to 0.2980±0.0085). The ^7Li/^6Li ratio tend to decrease towards the rim of the inclusion. The 10B/11B ratios are positively correlated with the ^9Be/11B ratios indicating the in situ decay of 10Be. However perturbations of the 10Be/B system are observed. They would correspond to an event which occurred approximately 2Myr after the formation of the <span class="hlt">CAI</span> and the irradiation of the <span class="hlt">CAI</span> precursors which is responsible for the 10Be observed in the core of the <span class="hlt">CAI</span>. These perturbations seem compatible with those observed for the 26Al/Mg system but they might be due to an irradiation of the already-formed, isolated <span class="hlt">CAI</span> which would have resulted in increased 10Be/^9Be ratios and low ^7Li/^6Li ratios in the margin of the <span class="hlt">CAI</span>. [1] McKeegan K. D. et al. (2000</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20070009991','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20070009991"><span id="translatedtitle">Isotopic Measurements in <span class="hlt">CAIs</span> with the Nanosims: Implications to the understanding of the Formation process of Ca, Al-Rich Inclusions</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Ito, M.; Messenger, S.; Walker, Robert M.</p> <p>2007-01-01</p> <p>Ca, Al-rich Inclusions (<span class="hlt">CAIs</span>) preserve evidence of thermal events that they experienced during their formation in the early solar system. Most <span class="hlt">CAIs</span> from CV and CO chondrites are characterized by large variations in O-isotopic compositions of primary minerals, with spinel, hibonite, and pyroxene being more O-16-rich than melilite and anorthite, with delta 17, O-18 = approx. -40%o (DELTA O-17 = delta O-17 - 0.52 x delta O-18 = approx. - 20%o ). These anomalous compositions cannot be accounted for by standard mass dependent fractionation and diffusive process of those minerals. It requires the presence of an anomalous oxygen reservoir of nucleosynthetic origin or mass independent fractionations before the formation of <span class="hlt">CAIs</span> in the early solar system. The CAMECA NanoSIMS is a new generation ion microprobe that offers high sensitivity isotopic measurements with sub 100 nm spatial resolution. The NanoSIMS has significantly improved abilities in the study of presolar grains in various kind of meteorites and the decay products of extinct nuclides in ancient solar system matter. This instrument promises significant improvements over other conventional ion probes in the precision isotopic characterization of sub-micron scales. We report the results of our first O isotopic measurements of various <span class="hlt">CAI</span> minerals from EK1-6-3 and 7R19-1(a) utilizing the JSC NanoSIMS 50L ion microprobe. We evaluate the measurement conditions, the instrumental mass fractionation factor (IMF) for O isotopic measurement and the accuracy of the isotopic ratio through the analysis of a San Carlos olivine standard and <span class="hlt">CAI</span> sample of 7R19-1(a).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013M%26PS...48.1440B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013M%26PS...48.1440B"><span id="translatedtitle">Mg and Si isotopic fractionation patterns in types B1 and B2 <fc><span class="hlt">CAI</span></fc>s: Implications for formation under different nebular conditions</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Bullock, Emma S.; Knight, Kim B.; Richter, Frank M.; Kita, Noriko T.; Ushikubo, Takayuki; MacPherson, Glenn J.; Davis, Andrew M.; Mendybaev, Ruslan A.</p> <p>2013-08-01</p> <p>Magnesium and silicon isotopic profiles across melilite grains in two type B1 and two type B2 calcium-aluminum-rich inclusions (<span class="hlt">CAIs</span>) reveal differing but constant enrichments in heavy isotopes everywhere except ≤1000 μm from the <span class="hlt">CAI</span> margins. There is no close correlation in the B1s or the B2s between isotopic composition and åkermanite content of the melilite, a measure of progressive igneous crystallization, yet such a correlation might be expected in a type B2: without a melilite mantle (as in B1s) to seal the interior off and prevent further evaporation, the melt would have maintained communication with the external gas. These observations indicate a model in which B1s and B2s solidified under differing conditions. The B2s solidified under lower hydrogen pressures (PH2 ≤ 10-4 - 10-5 bars) than did B1s (PH2 > 10-4 bars), so surface volatilization was slower in the B2s and internal chemical and isotopic equilibrium was maintained over the interval of melilite crystallization. The outermost zones of the <span class="hlt">CAIs</span> (≤1000 μm from the edge) are not consistently enriched in heavy isotopes relative to the interiors, as might be expected from diffusion-limited surface evaporation of the melt. In all cases, the magnesium in the <span class="hlt">CAI</span> margins is lighter than in the interiors. In one case, silicon in the margin also is lighter, but locally in some <span class="hlt">CAIs</span>, it is isotopically heavier near the surface. If melt evaporation played a role in the formation of these outer zones, a later event in many cases caused isotopic re-equilibration with an external and isotopically near-normal reservoir.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/2883288','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/2883288"><span id="translatedtitle">An <span class="hlt">investigation</span> of sex-linked differences to the toxic and to the pharmacological <span class="hlt">actions</span> of difenacoum: studies in mice and rats.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Winn, M J; Clegg, J A; Park, B K</p> <p>1987-03-01</p> <p>We have <span class="hlt">investigated</span> the <span class="hlt">actions</span> of the coumarin anticoagulant, difenacoum, in male and female rats and mice. In our first experiment difenacoum (0.5 mg kg-1) killed 50% of male mice within 9 days of its administration, whereas no female mice died during this study. In a second group of experiments, the anticoagulant effect of difenacoum in male and female rats was determined. Under resting conditions, the prothrombin complex activities (PCA) of male and female rats were not significantly different. Over the first 24 h after administration of difenacoum (0.4 mg kg-1 i.p.), there was a monoexponential fall in PCA in both sexes. However, 6, 12 and 24 h after difenacoum, the PCA in male rats was significantly (P less than 0.05) lower than in female rats. PCA began to recover over the subsequent 48 h in both sexes, during which time there was marked variability in recovery in female rats. The difference between the onset of <span class="hlt">action</span> of difenacoum in male and female rats did not appear to be due to a greater rate of elimination of the drug in female rats, since the plasma concentrations of difenacoum 24 h after its administration were the same in both sexes. The concentration of vitamin K1 in rat liver was also <span class="hlt">investigated</span>. Vitamin K1 levels were 35.1 +/- 18.6 ng (g liver)-1 (male), and 29.4 +/- 5.4 ng (g liver)-1 (females) in control rats, but 24 h after difenacoum, vitamin K1 levels were either very low, or undetectable in all rats.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:2883288</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://pubs.usgs.gov/sim/3006/','USGSPUBS'); return false;" href="http://pubs.usgs.gov/sim/3006/"><span id="translatedtitle">Thermal Maturity Patterns (<span class="hlt">CAI</span> and %Ro) in Upper Ordovician and Devonian Rocks of the Appalachian Basin: A Major Revision of USGS Map I-917-E Using New Subsurface Collections</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Repetski, John E.; Ryder, Robert T.; Weary, David J.; Harris, Anita G.; Trippi, Michael H.</p> <p>2008-01-01</p> <p>The conodont color alteration index (<span class="hlt">CAI</span>) introduced by Epstein and others (1977) and Harris and others (1978) is an important criterion for estimating the thermal maturity of Ordovician to Mississippian rocks in the Appalachian basin. Consequently, the <span class="hlt">CAI</span> isograd maps of Harris and others (1978) are commonly used by geologists to characterize the thermal and burial history of the Appalachian basin and to better understand the origin and distribution of oil and gas resources in the basin. The main objectives of our report are to present new <span class="hlt">CAI</span> isograd maps for Ordovician and Devonian rocks in the Appalachian basin and to interpret the geologic and petroleum resource implications of these maps. The <span class="hlt">CAI</span> isograd maps presented herein complement, and in some areas replace, the <span class="hlt">CAI</span>-based isograd maps of Harris and others (1978) for the Appalachian basin. The <span class="hlt">CAI</span> data presented in this report were derived almost entirely from subsurface samples, whereas the <span class="hlt">CAI</span> data used by Harris and others (1978) were derived almost entirely from outcrop samples. Because of the different sampling methods, there is little geographic overlap of the two data sets. The new data set is mostly from the Allegheny Plateau structural province and most of the data set of Harris and others (1978) is from the Valley and Ridge structural province, east of the Allegheny structural front.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/897543','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/897543"><span id="translatedtitle">Streamlined Approach for Environmental Restoration (SAFER) Plan for Corrective <span class="hlt">Action</span> Unit 553: Areas 19, 20 Mud Pits and Cellars, Nevada Test Site, Nevada, Rev. No. 0</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Boehlecke, Robert F.</p> <p>2006-11-01</p> <p>This Streamlined Approach for Environmental Restoration (SAFER) Plan addresses the <span class="hlt">actions</span> necessary for the closure of Corrective <span class="hlt">Action</span> Unit (CAU) 553: Areas 19, 20 Mud Pits and Cellars, Nevada Test Site (NTS), Nevada. It has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996) that was agreed to by the State of Nevada, the U.S. Department of Energy (DOE), and the U.S. Department of Defense. A SAFER may be performed when the following criteria are met: (1) Conceptual corrective <span class="hlt">actions</span> are clearly identified (although some degree of <span class="hlt">investigation</span> may be necessary to select a specific corrective <span class="hlt">action</span> before completion of the Corrective <span class="hlt">Action</span> <span class="hlt">Investigation</span> [<span class="hlt">CAI</span>]); (2) Uncertainty of the nature, extent, and corrective <span class="hlt">action</span> must be limited to an acceptable level of risk; (3) The SAFER Plan includes decision points and criteria for making data quality objective (DQO) decisions. The purpose of the <span class="hlt">investigation</span> will be to document and verify the adequacy of existing information; to affirm the decision for clean closure, closure in place, or no further <span class="hlt">action</span>; and to provide sufficient data to implement the corrective <span class="hlt">action</span>. The actual corrective <span class="hlt">action</span> selected will be based on characterization activities implemented under this SAFER Plan. This SAFER Plan identifies decision points developed in cooperation with the Nevada Department of Environmental Protection (NDEP), where the DOE, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) will reach consensus with the NDEP before beginning the next phase of work. Corrective <span class="hlt">Action</span> Unit 553 is located in Areas 19 and 20 of the NTS, approximately 65 miles (mi) northwest of Las Vegas, Nevada (Figure 1-1). Corrective <span class="hlt">Action</span> Unit 553 is comprised of the four Corrective <span class="hlt">Action</span> Sites (CASs) shown on Figure 1-1 and listed below: 19-99-01, Mud Spill; 19-99-11, Mud Spill; 20-09-09, Mud Spill; and 20-99-03, Mud Spill. There is sufficient information and process</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2009PhDT........41S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2009PhDT........41S"><span id="translatedtitle">The conceptual maps in the development of the course of biology of tenth degree: An <span class="hlt">investigation</span> experience <span class="hlt">action</span> in the classroom</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Samo Goyco, Marisol</p> <p></p> <p>This <span class="hlt">investigation</span> describes and combines the qualitative and quantitative methods of nature. The research I have work explore, observe, record and also it describes the experience to consider the education and teaching of the course. This <span class="hlt">investigation</span> is a research that our students from the biology course, since the constructivist approach identifying and correct mistake. In this <span class="hlt">investigation</span> there were participating twenty five students of tenth grade from a public school specialized in music. This research includes conceptual maps, computer integration, science programmed, internet, and broadcast and assessment approach. The research of conceptual maps establishes the correct method to perform capture the acknowledgement and attention of the <span class="hlt">investigators</span> and the students which represents a significant relation between the concepts. Thought the <span class="hlt">investigator</span> sustains on the cycle spiral of Carr and kemmis (1988) I design every unit considering the previous ideology of the student and elaborating the unit plan. Sustaining Maintain the methodology of the <span class="hlt">action</span> research. The methodology has response to a new teaching paradigm. Situate as a principal assignment of the professor to contribute in the process of active learning to the students. Also helps to have in this process a reflection in their function or goals. During the research I analyze and wrote the observation and materials. The <span class="hlt">investigator</span> express in her writing the final findings in every cycle. Also evaluates the map concepts the varied integration of activity and the assessment skills which are used through the socialized discussion. The socialized discussion communicates the participant concepts that should be attended. The students express between their peers and in front of the research of the <span class="hlt">investigator</span> how they felt in terms of resources and the development of the maps. At the moment of this information I design the next cycle responding to the outstanding needs, this reflection genre a</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26389125','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26389125"><span id="translatedtitle">Laboratory, Environmental, and Epidemiologic <span class="hlt">Investigation</span> and Regulatory Enforcement <span class="hlt">Actions</span> in Response to an Outbreak of Salmonella Bredeney Infections Linked to Peanut Butter.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Viazis, Stelios; Beal, Jennifer K; Monahan, Caitlin; Lanier, William A; Kreil, Katherine R; Melka, David C; Boden, William D; Dion, Jamie L; Miller, Zachary A; Nguyen, Thai-An; Gieraltowski, Laura B; Zink, Donald L</p> <p>2015-09-01</p> <p>Background.  In September 2012, the Centers for Disease Control and Prevention (CDC), U.S. Food and Drug Administration (FDA), and state and local partners <span class="hlt">investigated</span> an outbreak of Salmonella enterica serovar Bredeney linked to peanut butter (PB). Methods.  A case was defined as infection with the outbreak strain of Salmonella Bredeney between June 1, 2012 and October 31, 2012. Food exposure questionnaires were analyzed by the CDC to determine the food vehicle. The FDA reviewed production information from Retail Chain A's sole supplier of PB, Company A. The PB samples collected from case-patients and Company A were tested for Salmonella. Results.  Forty-two case-patients from 20 states were identified. Of 33 case-patients from whom food exposure information was obtained, 25 (76%) shopped at Retail Chain A and 25 (100%) purchased Company A PB. Three state health departments isolated the outbreak strain from opened jars of PB collected from case-patients. The FDA <span class="hlt">investigators</span> identified multiple deficiencies in current Good Manufacturing Practices (cGMPs) in Company A's manufacturing facility and determined that internal controls were insufficient to prevent shipment of contaminated product. The FDA isolated the outbreak strain of Salmonella Bredeney from implicated product collected at the firm and the environment of the firm's food production facility. Conclusions.  Timely laboratory, <span class="hlt">investigational</span>, and epidemiologic data led to the voluntary recall of PB by Company A. The FDA suspended Company A's food facility registration, prohibiting the firm from introducing food into interstate commerce. This outbreak underscores the need for effective preventive controls, including robust internal environmental monitoring programs, appropriate <span class="hlt">action</span> in response to contamination findings, and an improved understanding of food safety at the managerial and corporate levels.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4564807','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4564807"><span id="translatedtitle">Laboratory, Environmental, and Epidemiologic <span class="hlt">Investigation</span> and Regulatory Enforcement <span class="hlt">Actions</span> in Response to an Outbreak of Salmonella Bredeney Infections Linked to Peanut Butter</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Viazis, Stelios; Beal, Jennifer K.; Monahan, Caitlin; Lanier, William A.; Kreil, Katherine R.; Melka, David C.; Boden, William D.; Dion, Jamie L.; Miller, Zachary A.; Nguyen, Thai-An; Gieraltowski, Laura B.; Zink, Donald L.</p> <p>2015-01-01</p> <p>Background. In September 2012, the Centers for Disease Control and Prevention (CDC), U.S. Food and Drug Administration (FDA), and state and local partners <span class="hlt">investigated</span> an outbreak of Salmonella enterica serovar Bredeney linked to peanut butter (PB). Methods. A case was defined as infection with the outbreak strain of Salmonella Bredeney between June 1, 2012 and October 31, 2012. Food exposure questionnaires were analyzed by the CDC to determine the food vehicle. The FDA reviewed production information from Retail Chain A's sole supplier of PB, Company A. The PB samples collected from case-patients and Company A were tested for Salmonella. Results. Forty-two case-patients from 20 states were identified. Of 33 case-patients from whom food exposure information was obtained, 25 (76%) shopped at Retail Chain A and 25 (100%) purchased Company A PB. Three state health departments isolated the outbreak strain from opened jars of PB collected from case-patients. The FDA <span class="hlt">investigators</span> identified multiple deficiencies in current Good Manufacturing Practices (cGMPs) in Company A's manufacturing facility and determined that internal controls were insufficient to prevent shipment of contaminated product. The FDA isolated the outbreak strain of Salmonella Bredeney from implicated product collected at the firm and the environment of the firm's food production facility. Conclusions. Timely laboratory, <span class="hlt">investigational</span>, and epidemiologic data led to the voluntary recall of PB by Company A. The FDA suspended Company A's food facility registration, prohibiting the firm from introducing food into interstate commerce. This outbreak underscores the need for effective preventive controls, including robust internal environmental monitoring programs, appropriate <span class="hlt">action</span> in response to contamination findings, and an improved understanding of food safety at the managerial and corporate levels. PMID:26389125</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_23 --> <div id="page_24" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="461"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26389125','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26389125"><span id="translatedtitle">Laboratory, Environmental, and Epidemiologic <span class="hlt">Investigation</span> and Regulatory Enforcement <span class="hlt">Actions</span> in Response to an Outbreak of Salmonella Bredeney Infections Linked to Peanut Butter.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Viazis, Stelios; Beal, Jennifer K; Monahan, Caitlin; Lanier, William A; Kreil, Katherine R; Melka, David C; Boden, William D; Dion, Jamie L; Miller, Zachary A; Nguyen, Thai-An; Gieraltowski, Laura B; Zink, Donald L</p> <p>2015-09-01</p> <p>Background.  In September 2012, the Centers for Disease Control and Prevention (CDC), U.S. Food and Drug Administration (FDA), and state and local partners <span class="hlt">investigated</span> an outbreak of Salmonella enterica serovar Bredeney linked to peanut butter (PB). Methods.  A case was defined as infection with the outbreak strain of Salmonella Bredeney between June 1, 2012 and October 31, 2012. Food exposure questionnaires were analyzed by the CDC to determine the food vehicle. The FDA reviewed production information from Retail Chain A's sole supplier of PB, Company A. The PB samples collected from case-patients and Company A were tested for Salmonella. Results.  Forty-two case-patients from 20 states were identified. Of 33 case-patients from whom food exposure information was obtained, 25 (76%) shopped at Retail Chain A and 25 (100%) purchased Company A PB. Three state health departments isolated the outbreak strain from opened jars of PB collected from case-patients. The FDA <span class="hlt">investigators</span> identified multiple deficiencies in current Good Manufacturing Practices (cGMPs) in Company A's manufacturing facility and determined that internal controls were insufficient to prevent shipment of contaminated product. The FDA isolated the outbreak strain of Salmonella Bredeney from implicated product collected at the firm and the environment of the firm's food production facility. Conclusions.  Timely laboratory, <span class="hlt">investigational</span>, and epidemiologic data led to the voluntary recall of PB by Company A. The FDA suspended Company A's food facility registration, prohibiting the firm from introducing food into interstate commerce. This outbreak underscores the need for effective preventive controls, including robust internal environmental monitoring programs, appropriate <span class="hlt">action</span> in response to contamination findings, and an improved understanding of food safety at the managerial and corporate levels. PMID:26389125</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23445507','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23445507"><span id="translatedtitle">Genome-wide <span class="hlt">investigation</span> of cellular targets and mode of <span class="hlt">action</span> of the antifungal bacterial metabolite 2,4-diacetylphloroglucinol in Saccharomyces cerevisiae.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Troppens, Danielle M; Dmitriev, Ruslan I; Papkovsky, Dmitri B; O'Gara, Fergal; Morrissey, John P</p> <p>2013-05-01</p> <p>Saccharomyces cerevisiae is a proven model to <span class="hlt">investigate</span> the effects of small molecules and drugs on fungal and eukaryotic cells. In this study, the mode of <span class="hlt">action</span> of an antifungal metabolite, 2,4-diacetylphloroglucinol (DAPG), was determined. Applying a combination of genetic and physiological approaches, it was established that this bacterial metabolite acts as a proton ionophore and dissipates the proton gradient across the mitochondrial membrane. The uncoupling of respiration and ATP synthesis ultimately leads to growth inhibition and is the primary toxic effect of DAPG. A genome-wide screen identified 154 DAPG-tolerant mutants and showed that there are many alterations in cellular metabolism that can confer at least some degree of tolerance to this uncoupler. One mutant, ydc1, was studied in some more detail as it displayed increased tolerance to both DAPG and the uncoupler carbonylcyanide m-chlorophenylhydrazone (CCCP) and appears to be unconnected to other tolerant mutant strains. Deleting YDC1 alters sphingolipid homoeostasis in the cell, and we suggest here that this may be linked to reduced drug sensitivity. Sphingolipids and their derivatives are important eukaryotic signal molecules, and the observation that altering homoeostasis may affect yeast response to metabolic uncoupling agents raises some intriguing questions for future studies.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/102518','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/102518"><span id="translatedtitle">N,N-diethyl-4-aminoazobenzene (DEAB): acute <span class="hlt">actions</span> with respect to possible carcinogenicity as well as the role of solvents. Morphological and pharmacological <span class="hlt">investigations</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Danz, M; Klinger, W; Müller, D; Kleeberg, U; Glöckner, R; Ziebarth, D; Urban, H</p> <p>1978-01-01</p> <p>The acute <span class="hlt">action</span> of the azo dye DEAB was <span class="hlt">investigated</span> in Sprague-Dawley (SD) and Wistar (Wi) rats. The substance was dissolved both in DMSO and sunflower oil and was administered once by stomach tube. Cytochrome P-450-DEPENDENT N-demethylation of ethylmorphine and dimethylnitrosamine are differentially altered depending on the solvent used. The excretion of DEAB as well as of N,N-dimethyl-4-amino-azobenzene (DAB) is delayed and diminished if the substances are dissolved in DMSO. Beside these effects the mitotic number in the adrenal cortex is significantly elevated in both strains of rats. But, in SD rats only DMSO-solution of DEAB is effective. In Wi rats both are effective, the oily solution more than that in DMSO. In this respect DEAB resembles DAB and various other carcinogens which are efficient in stimulating adrenocortical cell division. Considering the positive short-term assay after three other substances which revealed carcinogenic properties in long-term experiments we conclude that also DEAB may be carcinogenic in adequate long-term examination.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3669743','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3669743"><span id="translatedtitle">Choosing <span class="hlt">Actions</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Rosenbaum, David A.; Chapman, Kate M.; Coelho, Chase J.; Gong, Lanyun; Studenka, Breanna E.</p> <p>2013-01-01</p> <p><span class="hlt">Actions</span> that are chosen have properties that distinguish them from <span class="hlt">actions</span> that are not. Of the nearly infinite possible <span class="hlt">actions</span> that can achieve any given task, many of the unchosen <span class="hlt">actions</span> are irrelevant, incorrect, or inappropriate. Others are relevant, correct, or appropriate but are disfavored for other reasons. Our research focuses on the question of what distinguishes <span class="hlt">actions</span> that are chosen from <span class="hlt">actions</span> that are possible but are not. We review studies that use simple preference methods to identify factors that contribute to <span class="hlt">action</span> choices, especially for object-manipulation tasks. We can determine which factors are especially important through simple behavioral experiments. PMID:23761769</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20526978','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20526978"><span id="translatedtitle"><span class="hlt">Action</span> semantics modulate <span class="hlt">action</span> prediction.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Springer, Anne; Prinz, Wolfgang</p> <p>2010-11-01</p> <p>Previous studies have demonstrated that <span class="hlt">action</span> prediction involves an internal <span class="hlt">action</span> simulation that runs time-locked to the real <span class="hlt">action</span>. The present study replicates and extends these findings by indicating a real-time simulation process (Graf et al., 2007), which can be differentiated from a similarity-based evaluation of internal <span class="hlt">action</span> representations. Moreover, results showed that <span class="hlt">action</span> semantics modulate <span class="hlt">action</span> prediction accuracy. The semantic effect was specified by the processing of <span class="hlt">action</span> verbs and concrete nouns (Experiment 1) and, more specifically, by the dynamics described by <span class="hlt">action</span> verbs (Experiment 2) and the speed described by the verbs (e.g., "to catch" vs. "to grasp" vs. "to stretch"; Experiment 3). These results propose a linkage between <span class="hlt">action</span> simulation and <span class="hlt">action</span> semantics as two yet unrelated domains, a view that coincides with a recent notion of a close link between motor processes and the understanding of <span class="hlt">action</span> language.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20160002232','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20160002232"><span id="translatedtitle">New Petrology, Mineral Chemistry and Stable MG Isotope Compositions of an Allende <span class="hlt">CAI</span>: EK-459-7-2</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Jeffcoat, C. R.; Kerekgyarto, A. G.; Lapen, T. J.; Righter, M.; Simon, J. I.; Ross, D. K.</p> <p>2016-01-01</p> <p>Calcium-aluminum-rich inclusions (<span class="hlt">CAIs</span>) are the key to understanding physical and chemical conditions in the nascent solar nebula. These inclusions have the oldest radiometric ages of solar system materials and are composed of phases that are predicted to condense early from a gas of solar composition. Thus, their chemistry and textures record conditions and processes in the earliest stages of development of the solar nebula. Type B inclusions are typically larger and more coarse grained than other types with substantial evidence that many of them were at least partially molten. Type B inclusions are further subdivided into Type B1 (possess thick melilite mantle) and Type B2 (lack melilite mantle). Despite being extensively studied, the origin of the melilite mantles of Type B1 inclusions remains uncertain. We present petrologic and chemical data for a Type B inclusion, EK-459-7-2, that bears features found in both Type B1 and B2 inclusions and likely represents an intermediate between the two types. Detailed studies of more of these intermediate objects may help to constrain models for Type B1 rim formation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/8786530','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/8786530"><span id="translatedtitle">The vasorelaxing <span class="hlt">action</span> of rutaecarpine: direct paradoxical effects on intracellular calcium concentration of vascular smooth muscle and endothelial cells.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wang, G J; Shan, J; Pang, P K; Yang, M C; Chou, C J; Chen, C F</p> <p>1996-03-01</p> <p>We have examined both the hypotensive effect and the mechanism of intracellular Ca++ regulation, underlying rutaecarpine (Rut)-induced vasodilatation. An i.v. bolus injection of Rut in anesthetized Sprague-Dawley rats produced a dose-dependent hypotensive effect. In isolated rat aorta rings, Rut (0.1-3 mu M) inhibited the phasic and tonic responses of norepinephrine- and phyenylephrine-induced contractions, respectively, mainly through an endothelium-dependent mechanism. However, the vasorelaxing effect of Rut (3 microM) persisted in denuded aorta, although to a much less extent than in intact tissue. As determined by the fura-2/AM (1-[2-(5-carboxyoxazol-2-yl)-6-aminobenzofuran-5-oxy]-2-(2'- amino-5'-methylphenoxy)-ethane-N,N,N,N-tetraacetic acid pentaacetoxymethyl ester) method, Rut (10 microM), in the presence of extracellular Ca++, suppressed the KCI-induced increment in the intracellular Ca++ concentration ([<span class="hlt">Ca++]i</span>) of cultured vascular smooth muscle cells (VSMC). Rut (10 microM) also attenuated the norepinephrine-induced peak rise of [<span class="hlt">Ca++]i</span> in VSMC placed in Ca++-free solution. On the other hand, Rut (1 and 10 microM) increased the level of [<span class="hlt">Ca++]i</span> of cultured endothelial cells (EC) in the presence of extracellular Ca++. In conclusion, Rut acts on both VSMC and EC directly. In VSMC, it reduces [<span class="hlt">Ca++]i</span> through the inhibition of Ca++ influx and Ca++ release from intracellular stores. In EC, Rut augments EC [<span class="hlt">Ca++]i</span> by increasing Ca++ influx, possibly leading to nitric oxide release. The paradoxical regulation of Ca++ in both VSMC and EC acts simultaneously to cause vasorelaxation which could account, at least in part, for the hypotensive <span class="hlt">action</span>. This is a most significant and a unique feature of this study. PMID:8786530</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/6769186','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/6769186"><span id="translatedtitle"><span class="hlt">Investigation</span> of molecular mechanisms in photodynamic <span class="hlt">action</span> and radiobiology with nanosecond flash photolysis and pulse radiolysis. Progress report, October 1, 1980-September 30, 1981</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Grossweiner, L I</p> <p>1981-06-01</p> <p>Laser flash photolysis experiments have led to a new mechanism for the ultraviolet photolysis of aqueous tryptophan (Trp), indole (Ind) and certain indole derivatives. Excitation at 265 nm leads to photoionization via a pre-fluorescent state with thermal activation. A new formula is proposed for predicting enzyme inactivation quantum yields. The predictions are in good agreement with measurements on six important enzymes at 254 nm and 280 nm. Kinetics models have been developed and tested for important stages in the photosensitization of DNA to near-ultraviolet radiation by furocoumarin compounds currently used for PUVA therapy (psoralen plus UV-A) of psoriasis and other human skin diseases. Experiments on photobinding of psoralen (Ps) and 8-methoxypsoralen (8-MOP) to calf thymus DNA are consistent with the assumption that equilibrium dark complexing of the furocoumarin to the DNA is a precondition for the formation of covalent monoadducts and cross-links. Singlet oxygen generation by furocoumarins has been <span class="hlt">investigated</span> with liposomes and human erythrocytes (rbc). Results obtained with 3-carbethoxypsoralen (3-CPs), an experimental alternate PUVA sensitizer claimed to be non-tumorigenic, show that 3-CPs interacts with liposome and rbc membranes in the dark. Studies on photosensitization of egg lecithin liposomes by methylene blue (MB) incorporated in the membrane have led to the new result that membrane lysis is a two-stage process. The first stage induced by red light irradiation leads to membrane damage initiated by O/sub 2/*. Membrane lysis takes place in the dark, second stage under the <span class="hlt">action</span> of mild hydrodynamic stress, such as slow gas bubbling.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21712504','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21712504"><span id="translatedtitle"><span class="hlt">Investigation</span> of the mode of <span class="hlt">action</span> underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Thompson, Chad M; Proctor, Deborah M; Haws, Laurie C; Hébert, Charles D; Grimes, Sheila D; Shertzer, Howard G; Kopec, Anna K; Hixon, J Gregory; Zacharewski, Timothy R; Harris, Mark A</p> <p>2011-09-01</p> <p>Chronic ingestion of high concentrations of hexavalent chromium [Cr(VI)] in drinking water induces intestinal tumors in mice. To <span class="hlt">investigate</span> the mode of <span class="hlt">action</span> (MOA) underlying these tumors, a 90-day drinking water study was conducted using similar exposure conditions as in a previous cancer bioassay, as well as lower (heretofore unexamined) drinking water concentrations. Tissue samples were collected in mice exposed for 7 or 90 days and subjected to histopathological, biochemical, toxicogenomic, and toxicokinetic analyses. Described herein are the results of toxicokinetic, biochemical, and pathological findings. Following 90 days of exposure to 0.3-520 mg/l of sodium dichromate dihydrate (SDD), total chromium concentrations in the duodenum were significantly elevated at ≥ 14 mg/l. At these concentrations, significant decreases in the reduced-to-oxidized glutathione ratio (GSH/GSSG) were observed. Beginning at 60 mg/l, intestinal lesions were observed including villous cytoplasmic vacuolization. Atrophy, apoptosis, and crypt hyperplasia were evident at ≥ 170 mg/l. Protein carbonyls were elevated at concentrations ≥ 4 mg/l SDD, whereas oxidative DNA damage, as assessed by 8-hydroxydeoxyguanosine, was not increased in any treatment group. Significant decreases in the GSH/GSSG ratio and similar histopathological lesions as observed in the duodenum were also observed in the jejunum following 90 days of exposure. Cytokine levels (e.g., interleukin-1β) were generally depressed or unaltered at the termination of the study. Overall, the data suggest that Cr(VI) in drinking water can induce oxidative stress, villous cytotoxicity, and crypt hyperplasia in the mouse intestine and may underlie the MOA of intestinal carcinogenesis in mice.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25681569','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25681569"><span id="translatedtitle"><span class="hlt">Investigation</span> on modes of toxic <span class="hlt">action</span> to rats based on aliphatic and aromatic compounds and comparison with fish toxicity based on exposure routes.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>He, Jia; Li, Jin J; Wen, Yang; Tai, Hong W; Yu, Yang; Qin, Wei C; Su, Li M; Zhao, Yuan H</p> <p>2015-06-01</p> <p>The modes of toxic <span class="hlt">action</span> (MOAs) play an important role in the assessment of the ecotoxicity of organic pollutants. However, few studies have been reported on the MOAs in rat toxicity. In this paper, the toxic contributions of functional groups in 1255 aromatic compounds were calculated from regression and were then compared with the toxic contributions in aliphatic compounds. The results show that some functional groups have same toxic contributions both in aromatic and aliphatic compounds, but some have not. To <span class="hlt">investigate</span> the MOAs in rat toxicity, the distribution of toxic ratio (TR) was examined for well-known baseline and less inert compounds and thresholds of log TR=0.3 and 0.5 were used to classify baseline, less inert and reactive compounds. The results showed that some compounds identified as baseline compounds in fish toxicity were also classified as baseline compounds in rat toxicity. Except for phenols and anilines which were identified as less inert compounds in fish toxicity, aromatic compounds with functional groups such as ether, nitrile, nitrophenol, isocyanatoe and chloro were identified as less inert chemicals in rat toxicity. Reactive compounds identified in fish toxicity exhibit greater toxicity to rats. These compounds can undergo nucleophilic substitution, acylation and Schiff base formation with biological macromolecules. The critical body residues (CBRs) calculated from absorption and bioconcentration show that log 1/CBRs in rat toxicity are not equal to that in fish for some compounds. It suggests that the exposure route can affect the identification of MOAs between these two species for these compounds.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/1167394','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/1167394"><span id="translatedtitle">Corrective <span class="hlt">Action</span> Decision Document/Closure Report for Corrective <span class="hlt">Action</span> Unit 567: Miscellaneous Soil Sites - Nevada National Security Site, Nevada</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Matthews, Patrick</p> <p>2014-12-01</p> <p>This Corrective <span class="hlt">Action</span> Decision Document/Closure Report presents information supporting the closure of Corrective <span class="hlt">Action</span> Unit (CAU) 567: Miscellaneous Soil Sites, Nevada National Security Site, Nevada. The purpose of this Corrective <span class="hlt">Action</span> Decision Document/Closure Report is to provide justification and documentation supporting the recommendation that no further corrective <span class="hlt">action</span> is needed for CAU 567 based on the implementation of the corrective <span class="hlt">actions</span>. The corrective <span class="hlt">actions</span> implemented at CAU 567 were developed based on an evaluation of analytical data from the <span class="hlt">CAI</span>, the assumed presence of COCs at specific locations, and the detailed and comparative analysis of the CAAs. The CAAs were selected on technical merit focusing on performance, reliability, feasibility, safety, and cost. The implemented corrective <span class="hlt">actions</span> meet all requirements for the technical components evaluated. The CAAs meet all applicable federal and state regulations for closure of the site. Based on the implementation of these corrective <span class="hlt">actions</span>, the DOE, National Nuclear Security Administration Nevada Field Office provides the following recommendations: • No further corrective <span class="hlt">actions</span> are necessary for CAU 567. • The Nevada Division of Environmental Protection issue a Notice of Completion to the DOE, National Nuclear Security Administration Nevada Field Office for closure of CAU 567. • CAU 567 be moved from Appendix III to Appendix IV of the FFACO.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=hungerford&pg=5&id=ED198007','ERIC'); return false;" href="http://eric.ed.gov/?q=hungerford&pg=5&id=ED198007"><span id="translatedtitle"><span class="hlt">Investigation</span> and <span class="hlt">Action</span> Skills for Environmental Problem Solving. A Curriculum Development Project Designed to Promote Autonomous Problem Solving in Environmental Education, Modules I-VI. Student Edition and Teacher's Edition.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Hungerford, Harold R.; And Others</p> <p></p> <p>Presented are six modules designed to help junior high school students develop the skills needed to study and take <span class="hlt">action</span> with respect to environmental problems. The first five modules cover basic <span class="hlt">investigation</span> skills: identifying environmental problems, using secondary sources, conducting surveys, interpreting data, and studying environmental…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=power+AND+sustainable&pg=7&id=EJ828814','ERIC'); return false;" href="http://eric.ed.gov/?q=power+AND+sustainable&pg=7&id=EJ828814"><span id="translatedtitle">The Role of Language & Discourse in the <span class="hlt">Investigation</span> of Privilege: Using Participatory <span class="hlt">Action</span> Research to Discuss Theory, Develop Methodology, & Interrupt Power</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Stoudt, Brett G.</p> <p>2009-01-01</p> <p>Rooted in feminist philosophy, critical race theory, and participatory <span class="hlt">action</span> research (PAR), I partnered with four faculty and four students at an elite, private, college preparatory day school for boys in order to examine bullying. In this article I closely examine the role of language and discourse when conducting counter hegemonic research…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Cinnamon&id=ED229789','ERIC'); return false;" href="http://eric.ed.gov/?q=Cinnamon&id=ED229789"><span id="translatedtitle"><span class="hlt">CAI</span> Invention Strategies.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Rodrigues, Raymond J.; Rodrigues, Dawn</p> <p></p> <p>Prewriting programs using computers fall into two broad categories: interactive and noninteractive. An early example of a noninteractive program is that of Ellen Nold, called "Cinnamon." Its purpose was to present the student with a series of content questions. In answering such questions, the student would be accumulating a set of data that could…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=cathode+AND+ray+AND+tube&pg=2&id=EJ020346','ERIC'); return false;" href="http://eric.ed.gov/?q=cathode+AND+ray+AND+tube&pg=2&id=EJ020346"><span id="translatedtitle"><span class="hlt">CAI</span> Physics Experiments</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Lindsay, Robert E.</p> <p>1970-01-01</p> <p>Describes a novel instructional method for physics involving the use of a computer assisted instruction system equipped with cathode-ray-tube terminals, light pen, and keyboard input. Discusses exercises with regard to content, mediation, scoring and control. Several examples of exercises are given along with results from student evaluation. (LC)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27252350','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27252350"><span id="translatedtitle">Stereoscopically Observing Manipulative <span class="hlt">Actions</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ferri, S; Pauwels, K; Rizzolatti, G; Orban, G A</p> <p>2016-08-01</p> <p>The purpose of this study was to <span class="hlt">investigate</span> the contribution of stereopsis to the processing of observed manipulative <span class="hlt">actions</span>. To this end, we first combined the factors "stimulus type" (<span class="hlt">action</span>, static control, and dynamic control), "stereopsis" (present, absent) and "viewpoint" (frontal, lateral) into a single design. Four sites in premotor, retro-insular (2) and parietal cortex operated specifically when <span class="hlt">actions</span> were viewed stereoscopically and frontally. A second experiment clarified that the stereo-<span class="hlt">action</span>-specific regions were driven by <span class="hlt">actions</span> moving out of the frontoparallel plane, an effect amplified by frontal viewing in premotor cortex. Analysis of single voxels and their discriminatory power showed that the representation of <span class="hlt">action</span> in the stereo-<span class="hlt">action</span>-specific areas was more accurate when stereopsis was active. Further analyses showed that the 4 stereo-<span class="hlt">action</span>-specific sites form a closed network converging onto the premotor node, which connects to parietal and occipitotemporal regions outside the network. Several of the specific sites are known to process vestibular signals, suggesting that the network combines observed <span class="hlt">actions</span> in peripersonal space with gravitational signals. These findings have wider implications for the function of premotor cortex and the role of stereopsis in human behavior. PMID:27252350</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4961020','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4961020"><span id="translatedtitle">Stereoscopically Observing Manipulative <span class="hlt">Actions</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Ferri, S.; Pauwels, K.; Rizzolatti, G.; Orban, G. A.</p> <p>2016-01-01</p> <p>The purpose of this study was to <span class="hlt">investigate</span> the contribution of stereopsis to the processing of observed manipulative <span class="hlt">actions</span>. To this end, we first combined the factors “stimulus type” (<span class="hlt">action</span>, static control, and dynamic control), “stereopsis” (present, absent) and “viewpoint” (frontal, lateral) into a single design. Four sites in premotor, retro-insular (2) and parietal cortex operated specifically when <span class="hlt">actions</span> were viewed stereoscopically and frontally. A second experiment clarified that the stereo-<span class="hlt">action</span>-specific regions were driven by <span class="hlt">actions</span> moving out of the frontoparallel plane, an effect amplified by frontal viewing in premotor cortex. Analysis of single voxels and their discriminatory power showed that the representation of <span class="hlt">action</span> in the stereo-<span class="hlt">action</span>-specific areas was more accurate when stereopsis was active. Further analyses showed that the 4 stereo-<span class="hlt">action</span>-specific sites form a closed network converging onto the premotor node, which connects to parietal and occipitotemporal regions outside the network. Several of the specific sites are known to process vestibular signals, suggesting that the network combines observed <span class="hlt">actions</span> in peripersonal space with gravitational signals. These findings have wider implications for the function of premotor cortex and the role of stereopsis in human behavior. PMID:27252350</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=multinational+AND+corporations+AND+globalization&id=ED403464','ERIC'); return false;" href="http://eric.ed.gov/?q=multinational+AND+corporations+AND+globalization&id=ED403464"><span id="translatedtitle"><span class="hlt">Action</span> Learning.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>1996</p> <p></p> <p>These four papers were presented at a symposium on <span class="hlt">action</span> learning moderated by Lex Dilworth at the 1996 conference of the Academy of Human Resource Development. "Developing an Infrastructure for Individual and Organizational Change: Transfer of Learning from an <span class="hlt">Action</span> Reflection Learning (ARL) Program" (ARL Inquiry) reports findings from a study…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED421454.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED421454.pdf"><span id="translatedtitle"><span class="hlt">Action</span> Research Monograph. A Collection of <span class="hlt">Action</span> Research <span class="hlt">Investigations</span> Done in the South Euclid-Lyndhurst City School System Which Were Initiated and Completed by District Teachers and Staff between September 1996 and September 1997.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Snodgrass, Donna, Ed.; Salzman, James, Ed.</p> <p></p> <p>The nine reports included in this monograph are: (1) "Phonemic Awareness/Multisensory Instruction: An Intervention for Kindergarten Children at Risk in Pre-Reading" (Marcia Anselmo and Patricia Kulp); (2) "The Effects of Reading Aloud vs. Sustained Silent Reading on Student Comprehension" (Karen Border and Mark Ranski); (3) "An <span class="hlt">Investigation</span> into…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/6271320','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/6271320"><span id="translatedtitle"><span class="hlt">Investigation</span> of molecular mechanisms in photodynamic <span class="hlt">action</span> and radiobiology with nanosecond flash photolysis and pulse radiolysis. Progress report, January 1, 1983-June 30, 1984</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Grossweiner, L.I.</p> <p>1984-01-01</p> <p>Photodynamic therapy (PDT) is a new modality for the treatment of malignant tumors based on the combined <span class="hlt">action</span> of visible light and a tumor-localizing photosensitizer, hematoporphyrin derivative (HpD). The putative <span class="hlt">action</span> mechanism involves the attack of singlet oxygen (..delta..) on tumeor tissue membranes. Model studies with liposomes have shown that an HpD fraction enriched in the active constituent (HpD-A) photosensitizes membranes lysis and lipid peroxidation. Dialysis measurements showed that HpD-A is 15% free at physiological conditions, compared to 100% binding of hematoporphyrin (HP). The suggested alternate PDT sensitizer, uroporphyrin I (Uro-I), had PHI/sub ..delta../ = 0.92 in SUV and sensitized lipid peroxidation. The rate of photobleaching of Uro-I was much faster than HpD-A. Studies with a mouse tumor model showed that encapsulation of HpD in liposomes (SUV) prior to intraperitoneal injection into athymic nude mice carrying implanted human tumors led to a 2-fold increase in HpD uptake by tumors. Liposomal injection led to good response of the tumor</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_24 --> <div id="page_25" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li class="active"><span>25</span></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="481"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016GeCoA.189...70K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016GeCoA.189...70K"><span id="translatedtitle">A link between oxygen, calcium and titanium isotopes in 26Al-poor hibonite-rich <span class="hlt">CAIs</span> from Murchison and implications for the heterogeneity of dust reservoirs in the solar nebula</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kööp, Levke; Davis, Andrew M.; Nakashima, Daisuke; Park, Changkun; Krot, Alexander N.; Nagashima, Kazuhide; Tenner, Travis J.; Heck, Philipp R.; Kita, Noriko T.</p> <p>2016-09-01</p> <p>PLACs (platy hibonite crystals) and related hibonite-rich calcium-, aluminum-rich inclusions (<span class="hlt">CAIs</span>; hereafter collectively referred to as PLAC-like <span class="hlt">CAIs</span>) have the largest nucleosynthetic isotope anomalies of all materials believed to have formed in the solar system. Most PLAC-like <span class="hlt">CAIs</span> have low inferred initial 26Al/27Al ratios and could have formed prior to injection or widespread distribution of 26Al in the solar nebula. In this study, we report 26Al-26Mg systematics combined with oxygen, calcium, and titanium isotopic compositions for a large number of newly separated PLAC-like <span class="hlt">CAIs</span> from the Murchison CM2 chondrite (32 <span class="hlt">CAIs</span> studied for oxygen, 26 of these also for 26Al-26Mg, calcium and titanium). Our results confirm (1) the large range of nucleosynthetic anomalies in 50Ti and 48Ca (our data range from -70‰ to +170‰ and -60‰ to +80‰, respectively), (2) the substantial range of Δ17O values (-28‰ to -17‰, with Δ17O = δ17O - 0.52 × δ18O), and (3) general 26Al-depletion in PLAC-like <span class="hlt">CAIs</span>. The multielement approach reveals a relationship between Δ17O and the degree of variability in 50Ti and 48Ca: PLAC-like <span class="hlt">CAIs</span> with the highest Δ17O (∼-17‰) show large positive and negative 50Ti and 48Ca anomalies, while those with the lowest Δ17O (∼-28‰) have small to no anomalies in 50Ti and 48Ca. These observations could suggest a physical link between anomalous 48Ca and 50Ti carriers and an 16O-poor reservoir. We suggest that the solar nebula was isotopically heterogeneous shortly after collapse of the protosolar molecular cloud, and that the primordial dust reservoir, in which anomalous carrier phases were heterogeneously distributed, was 16O-poor (Δ17O ⩾ -17‰) relative to the primordial gaseous (CO + H2O) reservoir (Δ17O < -35‰). However, other models such as CO self-shielding in the protoplanetary disk are also considered to explain the link between oxygen and calcium and titanium isotopes in PLAC-like <span class="hlt">CAIs</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3936325','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3936325"><span id="translatedtitle"><span class="hlt">Action</span> perception predicts <span class="hlt">action</span> performance</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Bailey, Heather R.; Kurby, Christopher A.; Giovannetti, Tania; Zacks, Jeffrey M.</p> <p>2013-01-01</p> <p>Everyday <span class="hlt">action</span> impairments often are observed in demented older adults, and they are common potential barriers to functional independence. We evaluated whether the ability to segment and efficiently encode activities is related to the ability to execute activities. Further, we evaluated whether brain regions important for segmentation also were important for <span class="hlt">action</span> performance. Cognitively healthy older adults and those with very mild or mild dementia of the Alzheimer's type watched and segmented movies of everyday activities and then completed the Naturalistic <span class="hlt">Action</span> Test. Structural MRI was used to measure volume in the dorsolateral prefrontal cortex (DLPFC), medial temporal lobes (MTL), posterior cortex, and anterior cingulate cortex (ACC). Dementia status and the ability to segment everyday activities strongly predicted naturalistic <span class="hlt">action</span> performance, and MTL volume largely accounted for this relationship. In addition, the current results supported the Omission-Commission Model: Different cognitive and neurological mechanisms predicted different types of <span class="hlt">action</span> error. Segmentation, dementia severity, and MTL volume predicted everyday omission errors, DLPFC volume predicted commission errors, and ACC volume predicted <span class="hlt">action</span> additions. These findings suggest that event segmentation may be critical for effective <span class="hlt">action</span> production, and that the segmentation and production of activities may recruit the same event representation system. PMID:23851113</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23851113','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23851113"><span id="translatedtitle"><span class="hlt">Action</span> perception predicts <span class="hlt">action</span> performance.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bailey, Heather R; Kurby, Christopher A; Giovannetti, Tania; Zacks, Jeffrey M</p> <p>2013-09-01</p> <p>Everyday <span class="hlt">action</span> impairments often are observed in demented older adults, and they are common potential barriers to functional independence. We evaluated whether the ability to segment and efficiently encode activities is related to the ability to execute activities. Further, we evaluated whether brain regions important for segmentation also were important for <span class="hlt">action</span> performance. Cognitively healthy older adults and those with very mild or mild dementia of the Alzheimer's type watched and segmented movies of everyday activities and then completed the Naturalistic <span class="hlt">Action</span> Test. Structural MRI was used to measure volume in the dorsolateral prefrontal cortex (DLPFC), medial temporal lobes (MTL), posterior cortex, and anterior cingulate cortex (ACC). Dementia status and the ability to segment everyday activities strongly predicted naturalistic <span class="hlt">action</span> performance, and MTL volume largely accounted for this relationship. In addition, the current results supported the Omission-Commission Model: Different cognitive and neurological mechanisms predicted different types of <span class="hlt">action</span> error. Segmentation, dementia severity, and MTL volume predicted everyday omission errors, DLPFC volume predicted commission errors, and ACC volume predicted <span class="hlt">action</span> additions. These findings suggest that event segmentation may be critical for effective <span class="hlt">action</span> production, and that the segmentation and production of activities may recruit the same event representation system.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2015JAMTP..56..966B&link_type=ABSTRACT','NASAADS'); return false;" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2015JAMTP..56..966B&link_type=ABSTRACT"><span id="translatedtitle"><span class="hlt">Investigation</span> of changes in the spherical shell shape under the <span class="hlt">action</span> of pulsed loading due to contact interaction with a rigid block</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Bazhenov, V. G.; Varavin, D. A.; Kibets, A. I.; Ryabov, A. A.; Romanov, V. I.</p> <p>2015-11-01</p> <p>An axisymmetric problem of high strains in a spherical lead shell enclosed into an aluminum "spacesuit" under the <span class="hlt">action</span> of pulsed loading is considered. The shell straining is described with the use of equations of mechanics of elastoviscoplastic media in Lagrangian variables, and the kinematic relations are determined in the current state metrics. Equations of state are taken in the form of equations of the flow theory with isotropic hardening. The problem is solved numerically by using the variational difference method and the "cross" explicit scheme of integration with respect to time. The influence of the yield stress as a function of the strain rate on changes in the shell shape is studied for different values of loading. The calculated final shape and residual strains are demonstrated to be in good agreement with experimental data.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/1798760','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/1798760"><span id="translatedtitle"><span class="hlt">Action</span> spectra again?</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Coohill, T P</p> <p>1991-11-01</p> <p><span class="hlt">Action</span> spectroscopy has a long history and is of central importance to photobiological studies. <span class="hlt">Action</span> spectra were among the first assays to point to chlorophyll as the molecule most responsible for plant growth and to DNA as the genetic material. It is useful to construct <span class="hlt">action</span> spectra early in the <span class="hlt">investigation</span> of new areas of photobiological research in an attempt to determine the wavelength limits of the radiation region causing the studied response. But due to the severe absorption of ultraviolet (UV) radiation by biological samples, UV <span class="hlt">action</span> spectra were first limited to small cells (bacteria and fungi). Advances in techniques (e.g. single cell culture) and analysis allowed accurate <span class="hlt">action</span> spectra to be reported even for mammalian cells. But precise analytical <span class="hlt">action</span> spectra are often difficult to obtain when large, pigmented, or groups of cells are <span class="hlt">investigated</span>. Here some <span class="hlt">action</span> spectra are limited in interpretation and merely supply a wavelength vs effect curve. When polychromatic sources are employed, the interpretation of <span class="hlt">action</span> spectra is even more complex and formidable. But such polychromatic <span class="hlt">action</span> spectra can be more directly related to ambient responses. Since precise <span class="hlt">action</span> spectra usually require the completion of a relatively large number of careful experiments using somewhat sophisticated equipment over a range of at least six wavelengths, they are often not pursued. But they remain central to the elucidation of the effect being studied. The worldwide community has agreed that stratospheric ozone is depleting, with the possibility of a consequent rise in the amount of UV-B (290-320 nm) reaching the earth's surface. It is therefore essential that new <span class="hlt">action</span> spectra be completed for UV-B effects on a large variety of responses of human, animal, and aquatic plant systems. Combining these <span class="hlt">action</span> spectra with the known amounts of UV-B reaching the biosphere can give rise to solar UV effectiveness spectra that, in turn, can give rise to estimates</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016GeCoA.183..176H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016GeCoA.183..176H"><span id="translatedtitle">Microstructural constraints on complex thermal histories of refractory <span class="hlt">CAI</span>-like objects in an amoeboid olivine aggregate from the ALHA77307 CO3.0 chondrite</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Han, Jangmi; Brearley, Adrian J.</p> <p>2016-06-01</p> <p>We have carried out a FIB/TEM study of refractory <span class="hlt">CAI</span>-like objects in one AOA from the ALHA77307 CO3.0 chondrite. The <span class="hlt">CAI</span>-like objects in the AOA consist of a zoned sequence with a spinel-rich core through an intergrowth layer of spinel and Al-Ti-rich diopside to a diopside rim. The spinel-rich core consists of polycrystalline aggregates of spinel and ±minor melilite showing equilibrated grain boundary textures. The intergrowth layer contains fine-grained diopside and spinel with minor anorthite with highly curved and embayed grain boundaries. The diopside rim consists of polycrystalline aggregates of diopside. The compositions of pyroxene change significantly outward from Al-Ti-rich diopside in contact with the spinel-rich core to Al-Ti-poor diopside next to the surrounding olivine of the AOA. Overall microstructural and chemical characteristics suggest that the spinel-rich core formed under equilibrium conditions whereas the intergrowth layer is the result of reactions that occurred under conditions that departed significantly from equilibrium. The remarkable changes in formation conditions of the <span class="hlt">CAI</span>-like objects may have been achieved by transport and injection of refractory objects into a region of a partially-condensed, Ca,Ti-saturated gas which reacted with spinel and melilite to form Al-Ti-rich diopside. Crystallographically-oriented TiO2 nanoparticles decorate the grain boundaries between spinel grains and between spinel and Al-Ti-rich diopside grains. During the disequilibrium back-reaction of spinel with a partially-condensed, Ca,Ti-saturated gas, metastable TiO2 nanoparticles may have condensed by an epitaxial nucleation mechanism and grown on the surface of spinel. These TiO2 nanoparticles are disordered intergrowths of the two TiO2 polymorphs, anatase and rutile. These nanoparticles are inferred to have nucleated as anatase that underwent partial transformation into rutile. The local presence of the TiO2 nanoparticles and intergrowth of anatase and</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26582127','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26582127"><span id="translatedtitle">Copper(II) complexes with naringenin and hesperetin: cytotoxic activity against A 549 human lung adenocarcinoma cells and <span class="hlt">investigation</span> on the mode of <span class="hlt">action</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tamayo, Lenka V; Gouvea, Ligiane R; Sousa, Anna C; Albuquerque, Ronniel M; Teixeira, Sarah Fernandes; de Azevedo, Ricardo Alexandre; Louro, Sonia R W; Ferreira, Adilson Kleber; Beraldo, Heloisa</p> <p>2016-02-01</p> <p>Copper(II) complexes [Cu(H2O)2 (L1)(phen)](ClO4) (1) and [Cu(H2O)(L2)(phen)](ClO4) (2) (HL1 = naringenin; HL2 = hesperetin) were obtained, in which an anionic flavonoid ligand is attached to the metal center along with 1,10-phenanthroline (phen) as co-ligand. Complexes (1) and (2) were assayed for their cytotoxic activity against A549 lung carcinoma and against normal lung fibroblasts (LL-24) and human umbilical vein endothelial cells (HUVEC). We found IC50 = 16.42 µM (1) and IC50 = 5.82 µM (2) against A549 tumor cells. Complexes (1) and (2) exhibited slight specificity, being more cytotoxic against malignant than against non-malignant cells. 1 and 2 induced apoptosis on A549 cells in a mitochondria-independent pathway, and showed antioxidant activity. The antioxidant effect of the complexes could possibly improve their apoptotic <span class="hlt">action</span>, most likely by a PI3K-independent reduction of autophagy. Complexes (1) and (2) interact in vitro with calf thymus DNA by an intercalative binding mode. EPR data indicated that 1 and 2