Science.gov

Sample records for action levels fals

  1. 30 CFR 62.120 - Action level.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Action level. 62.120 Section 62.120 Mineral... OCCUPATIONAL NOISE EXPOSURE § 62.120 Action level. If during any work shift a miner's noise exposure equals or exceeds the action level the mine operator must enroll the miner in a hearing conservation program...

  2. 10 CFR 850.23 - Action level.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Action level. 850.23 Section 850.23 Energy DEPARTMENT OF ENERGY CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM Specific Program Requirements § 850.23 Action level. (a) The responsible employer must include in its CBDPP an action level that is no greater than 0.2...

  3. 10 CFR 850.23 - Action level.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Action level. 850.23 Section 850.23 Energy DEPARTMENT OF ENERGY CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM Specific Program Requirements § 850.23 Action level... monitoring. (b) If an airborne concentration of beryllium is at or above the action level, the...

  4. 10 CFR 850.23 - Action level.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Action level. 850.23 Section 850.23 Energy DEPARTMENT OF ENERGY CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM Specific Program Requirements § 850.23 Action level... monitoring. (b) If an airborne concentration of beryllium is at or above the action level, the...

  5. 10 CFR 850.23 - Action level.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Action level. 850.23 Section 850.23 Energy DEPARTMENT OF ENERGY CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM Specific Program Requirements § 850.23 Action level... monitoring. (b) If an airborne concentration of beryllium is at or above the action level, the...

  6. 10 CFR 850.23 - Action level.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Action level. 850.23 Section 850.23 Energy DEPARTMENT OF ENERGY CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM Specific Program Requirements § 850.23 Action level. (a) The responsible employer must include in its CBDPP an action level that is no greater than 0.2 µg/m3, calculated as an 8-hour TWA exposure,...

  7. Decoding actions at different levels of abstraction.

    PubMed

    Wurm, Moritz F; Lingnau, Angelika

    2015-05-20

    Brain regions that mediate action understanding must contain representations that are action specific and at the same time tolerate a wide range of perceptual variance. Whereas progress has been made in understanding such generalization mechanisms in the object domain, the neural mechanisms to conceptualize actions remain unknown. In particular, there is ongoing dissent between motor-centric and cognitive accounts whether premotor cortex or brain regions in closer relation to perceptual systems, i.e., lateral occipitotemporal cortex, contain neural populations with such mapping properties. To date, it is unclear to which degree action-specific representations in these brain regions generalize from concrete action instantiations to abstract action concepts. However, such information would be crucial to differentiate between motor and cognitive theories. Using ROI-based and searchlight-based fMRI multivoxel pattern decoding, we sought brain regions in human cortex that manage the balancing act between specificity and generality. We investigated a concrete level that distinguishes actions based on perceptual features (e.g., opening vs closing a specific bottle), an intermediate level that generalizes across movement kinematics and specific objects involved in the action (e.g., opening different bottles with cork or screw cap), and an abstract level that additionally generalizes across object category (e.g., opening bottles or boxes). We demonstrate that the inferior parietal and occipitotemporal cortex code actions at abstract levels whereas the premotor cortex codes actions at the concrete level only. Hence, occipitotemporal, but not premotor, regions fulfill the necessary criteria for action understanding. This result is compatible with cognitive theories but strongly undermines motor theories of action understanding. PMID:25995462

  8. Relationship of Focally Amplified Long Noncoding on Chromosome 1 (FAL1) lncRNA with E2F Transcription Factors in Thyroid Cancer.

    PubMed

    Jeong, Seonhyang; Lee, Jandee; Kim, Daham; Seol, Mi-Youn; Lee, Woo Kyung; Jeong, Jong Ju; Nam, Kee-Hyun; Jung, Sang Geun; Shin, Dong Yeob; Lee, Eun Jig; Chung, Woong Youn; Jo, Young Suk

    2016-01-01

    Recent functional genomic studies revealed that the oncogenic activity of focally amplified lncRNA on chromosome 1 (FAL1, ENSG00000228126) contributes to tumor growth by p21 repression in human cancers. However, the expression of FAL1 was not investigated in papillary thyroid cancer (PTC). We aimed to determine if FAL1 was up-regulated in PTC compared to paired contralateral normal thyroid tissues, and to investigate the potential targets of this lncRNA and its clinicopathological significance in PTC. We analyzed FAL1 and p21 expression levels in 100 PTC samples and matched normal thyroid tissue by qRT-PCR. Using lncRNA microarray data from the Gene Expression Omnibus (accession no. GSE61763), we explored potential targets of FAL1 by Gene Set Enrichment Analysis, followed by verification by qRT-PCR in our PTC samples. A cross-sectional observational study was conducted to investigate the relationship between patients' clinicopathological features and FAL1 expression. FAL1 expression was significantly higher in PTC than in paired normal thyroid tissues (paired t test, P < 0.001). p21 mRNA expression was also increased, not decreased, in PTC, and had no correlation with FAL1 expression (r = 0.0897, P = 0.4002). Gene Set Enrichment Analysis, using publicly available microarray data, indicated that a gene set related to the cell cycle, including E2F transcription factors 1 and 2, and cyclin D1, was coordinately enriched among samples with high FAL1 expression. A volcano plot showed that E2F1, E2F2, and VEGFA mRNAs were increased in the high FAL1 samples. In clinicopathological analyses, multifocality was more frequently observed in PTC patients with high FAL1 (P = 0.018). Multivariate analysis showed that high FAL1 expression increased the risk of multifocality (after adjustment for clinical variables, OR = 4.019, CI = 1.041-11.020, P = 0.043). FAL1 may have a role in cell-cycle progression and may be associated with aggressive tumor

  9. Industrial Sites Project Establishment of Final Action Levels, Rev. No.: 0

    SciTech Connect

    Boehlecke, Robert F.

    2006-02-01

    The U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) oversees numerous sites on the Nevada Test Site (NTS) and other locations in the State of Nevada that have been impacted by activities related to the development and testing of nuclear devices and by other activities. NNSA/NSO is responsible for protecting members of the public, including site workers, from harmful exposure to both chemical and radiological contaminants at these sites as they remediate these sites. The Nevada Division of Environmental Protection (NDEP) is the primary state agency responsible for protection of human health and the environment with respect to chemical and radiological wastes. In 1996 the DOE, U.S. Department of Defense, and the State of Nevada entered into an agreement known as the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996). Appendix VI to the FFACO describes the strategy employed to plan, implement, and complete environmental corrective action activities at NTS and other locations in the state of Nevada. One of the categories of corrective action units (CAUs) is Industrial Sites, which consists of approximately 1,150 locations that may require some level of investigation and corrective action. To evaluate the need for the extent of corrective action at a particular site, NNSA/NSO assesses the potential impacts to receptors by comparing measurements of contaminant concentrations to risk-based (chemical) and dose-based (radionuclide) standards (action levels). Preliminary action levels (PALs) are established as part of the data quality objective (DQO) process, and are presented in one or more FFACO documents generated as part of the corrective action process. This document formally defines and clarifies the NDEP-approved process NNSA/NSO Industrial Sites Project uses to fulfill the requirements of the FFACO and state regulations. This process establishes final action levels (FALs) based on the risk

  10. Action Research: Improving Graduate-Level Writing

    ERIC Educational Resources Information Center

    Carter, Nari

    2012-01-01

    I am a doctoral student enrolled in an educational research program. While completing an action research course, I conducted research to improve my academic writing and to develop skills for formulating arguments about educational issues. From this research I developed an appreciation for and an understanding of good writing habits and elements of…

  11. Oncogenic long noncoding RNA FAL1 in human cancer

    PubMed Central

    Zhong, Xiaomin; Hu, Xiaowen; Zhang, Lin

    2015-01-01

    Long non-coding RNAs (lncRNAs) are defined as RNA transcripts larger than 200 nucleotides that do not appear to have protein-coding potential. Accumulating evidence indicates that lncRNAs are involved in tumorigenesis. Our work reveals that lncRNA FAL1 (focally amplified lncRNA on chromosome 1) is frequently and focally amplified in human cancers and mediates oncogenic functions. PMID:27308441

  12. Corrective Action Decision Document/Closure Report for Corrective Action Unit 106: Area 5, 11 Frenchman Flat Atmospheric Sites, Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews and Dawn Peterson

    2011-09-01

    Corrective Action Unit 106 comprises four corrective action sites (CASs): (1) 05-20-02, Evaporation Pond; (2) 05-23-05, Atmospheric Test Site - Able; (3) 05-45-04, 306 GZ Rad Contaminated Area; (4) 05-45-05, 307 GZ Rad Contaminated Area. The purpose of this CADD/CR is to provide justification and documentation supporting the recommendation that no further corrective action is needed for CAU 106 based on the implementation of corrective actions. The corrective action of clean closure was implemented at CASs 05-45-04 and 05-45-05, while no corrective action was necessary at CASs 05-20-02 and 05-23-05. Corrective action investigation (CAI) activities were performed from October 20, 2010, through June 1, 2011, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 106: Areas 5, 11 Frenchman Flat Atmospheric Sites. The approach for the CAI was divided into two facets: investigation of the primary release of radionuclides, and investigation of other releases (mechanical displacement and chemical releases). The purpose of the CAI was to fulfill data needs as defined during the data quality objective (DQO) process. The CAU 106 dataset of investigation results was evaluated based on a data quality assessment. This assessment demonstrated the dataset is complete and acceptable for use in fulfilling the DQO data needs. Investigation results were evaluated against final action levels (FALs) established in this document. A radiological dose FAL of 25 millirem per year was established based on the Industrial Area exposure scenario (2,250 hours of annual exposure). The only radiological dose exceeding the FAL was at CAS 05-45-05 and was associated with potential source material (PSM). It is also assumed that additional PSM in the form of depleted uranium (DU) and DU-contaminated debris at CASs 05-45-04 and 05-45-05 exceed the FAL. Therefore, corrective actions were undertaken at these CASs that consisted of removing PSM and collecting verification

  13. Corrective Action Decision Document/Closure Report for Corrective Action Unit 365: Baneberry Contamination Area, Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews

    2011-09-01

    Corrective Action Unit 365 comprises one corrective action site (CAS), CAS 08-23-02, U-8d Contamination Area. The purpose of this CADD/CR is to provide justification and documentation supporting the recommendation that no further corrective action is needed for CAU 365 based on the implementation of the corrective action of closure in place with a use restriction (UR). Corrective action investigation (CAI) activities were performed from January 18, 2011, through August 2, 2011, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 365: Baneberry Contamination Area. The purpose of the CAI was to fulfill data needs as defined during the data quality objective (DQO) process. The CAU 365 dataset of investigation results was evaluated based on a data quality assessment. This assessment demonstrated the dataset is complete and acceptable for use in supporting the DQO decisions. Investigation results were evaluated against final action levels (FALs) established in this document. A radiological dose FAL of 25 millirem per year was established based on the Remote Work Area exposure scenario (336 hours of annual exposure). Radiological doses exceeding the FAL were found to be present to the southwest of the Baneberry crater. It was also assumed that radionuclide levels present within the crater and fissure exceed the FAL. Corrective actions were undertaken that consisted of establishing a UR and posting warning signs for the crater, fissure, and the area located to the southwest of the crater where soil concentrations exceeded the FAL. These URs were recorded in the FFACO database; the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) Facility Information Management System; and the NNSA/NSO CAU/CAS files. Therefore, NNSA/NSO provides the following recommendations: (1) No further corrective actions beyond what are described in this document are necessary for CAU 365. (2) A Notice of Completion to

  14. Scientists, educators, and national standards: Action at the local level

    SciTech Connect

    1994-04-01

    This volume contains full papers presented at the Forum entitled Scientists, Educators, and National Standards- Action at the Local Level held April 14-15, 1994. Records for the database have been prepared for the individual reports contained herein.

  15. Corrective Action Decision Document for Corrective Action Unit 563: Septic Systems, Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Grant Evenson

    2008-02-01

    This Corrective Action Decision Document has been prepared for Corrective Action Unit (CAU) 563, Septic Systems, in accordance with the Federal Facility Agreement and Consent Order (FFACO, 1996; as amended January 2007). The corrective action sites (CASs) for CAU 563 are located in Areas 3 and 12 of the Nevada Test Site, Nevada, and are comprised of the following four sites: •03-04-02, Area 3 Subdock Septic Tank •03-59-05, Area 3 Subdock Cesspool •12-59-01, Drilling/Welding Shop Septic Tanks •12-60-01, Drilling/Welding Shop Outfalls The purpose of this Corrective Action Decision Document is to identify and provide the rationale for the recommendation of a corrective action alternative (CAA) for the four CASs within CAU 563. Corrective action investigation (CAI) activities were performed from July 17 through November 19, 2007, as set forth in the CAU 563 Corrective Action Investigation Plan (NNSA/NSO, 2007). Analytes detected during the CAI were evaluated against appropriate final action levels (FALs) to identify the contaminants of concern (COCs) for each CAS. The results of the CAI identified COCs at one of the four CASs in CAU 563 and required the evaluation of CAAs. Assessment of the data generated from investigation activities conducted at CAU 563 revealed the following: •CASs 03-04-02, 03-59-05, and 12-60-01 do not contain contamination at concentrations exceeding the FALs. •CAS 12-59-01 contains arsenic and chromium contamination above FALs in surface and near-surface soils surrounding a stained location within the site. Based on the evaluation of analytical data from the CAI, review of future and current operations at CAS 12-59-01, and the detailed and comparative analysis of the potential CAAs, the following corrective actions are recommended for CAU 563.

  16. Action recognition depends on observer's level of action control and social personality traits.

    PubMed

    Ondobaka, Sasha; Newman-Norlund, Roger D; de Lange, Floris P; Bekkering, Harold

    2013-01-01

    Humans recognize both the movement (physical) goals and action (conceptual) goals of individuals with whom they are interacting. Here, we assessed whether spontaneous recognition of others' goals depends on whether the observers control their own behavior at the movement or action level. We also examined the relationship between individual differences in empathy and ASD-like traits, and the processing of other individual's movement and action goals that are known to be encoded in the "mirroring" and "mentalizing" brain networks. In order to address these questions, we used a computer-based card paradigm that made it possible to independently manipulate movement and action congruency of observed and executed actions. In separate blocks, participants were instructed to select either the right or left card (movement-control condition) or the higher or lower card (action-control condition), while we manipulated action- and movement-congruency of both actors' goals. An action-congruency effect was present in all conditions and the size of this effect was significantly correlated with self-reported empathy and ASD-like traits. In contrast, movement-congruency effects were only present in the movement-control block and were strongly dependent on action-congruency. These results illustrate that spontaneous recognition of others' behavior depends on the control scheme that is currently adopted by the observer. The findings suggest that deficits in action recognition are related to abnormal synthesis of perceived movements and prior conceptual knowledge that are associated with activations in the "mirroring" and "mentalizing" cortical networks. PMID:24303046

  17. U.S. Homes Above EPA's Radon Action Level

    EPA Science Inventory

    This indicator presents the estimated number of homes with indoor radon levels over EPA's radon action level—the recommended maximum concentration for indoor radon—and the number of homes with operating radon mitigation systems. Radon is a human carcinogen that seeps into base...

  18. Corrective Action Decision Document/Closure Report for Corrective Action Unit 560: Septic Systems, Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Grant Evenson

    2010-04-01

    Corrective Action Unit 560 comprises seven corrective action sites (CASs): •03-51-01, Leach Pit •06-04-02, Septic Tank •06-05-03, Leach Pit •06-05-04, Leach Bed •06-59-03, Building CP-400 Septic System •06-59-04, Office Trailer Complex Sewage Pond •06-59-05, Control Point Septic System The purpose of this CADD/CR is to provide justification and documentation supporting the recommendation for closure of CAU 560 with no further corrective action. To achieve this, corrective action investigation (CAI) activities were performed from October 7, 2008, through February 24, 2010, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 560: Septic Systems, Nevada Test Site, Nevada, and Record of Technical Change No. 1. The purpose of the CAI was to fulfill the following data needs as defined during the data quality objective (DQO) process: •Determine whether contaminants of concern (COCs) are present. •If COCs are present, determine their nature and extent. •Provide sufficient information and data to complete appropriate corrective actions. The CAU 560 dataset from the investigation results was evaluated based on the data quality indicator parameters. This evaluation demonstrated the quality and acceptability of the dataset for use in fulfilling the DQO data needs. Analytes detected during the CAI were evaluated against final action levels (FALs) established in this document. The following contaminants were determined to be present at concentrations exceeding their corresponding FALs: •No contamination exceeding the FALs was identified at CASs 03-51-01, 06-04-02, and 06-59-04. •The soil at the base of the leach pit chamber at CAS 06-05-03 contains arsenic above the FAL of 23 milligrams per kilogram (mg/kg) and polychlorinated biphenyl (PCBs) above the FAL of 0.74 mg/kg, confined vertically from a depth of approximately 5 to 20 feet (ft) below ground surface. The contamination is confined laterally to the walls of the

  19. Corrective Action Decision Document/Closure Report for Corrective Action Unit 219: Septic Systems and Injection Wells, Nevada Test Site, Nevada, Rev. No.: 0

    SciTech Connect

    David Strand

    2006-05-01

    . Analytes detected during the CAI were evaluated against final action levels (FALs) established in this document. A Tier 2 evaluation was conducted, and a FAL of 185,000 micrograms per kilogram was calculated for chlordane at CASs 16-04-01, 16-04-02, and 16-04-03 based on an occasional use area exposure scenario. This evaluation of chlordane based on the Tier 2 FAL determined that no FALs were exceeded. Therefore, the DQO data needs were met, and it was determined that no corrective action (based on risk to human receptors) is necessary for the site. The following contaminants were determined to be present at concentrations exceeding their corresponding FALs: (1) The surface soil surrounding the main concrete pad at CAS 23-20-01 contained Aroclor-1254, Aroclor-1260, and chlordane above the FALs. This soil, along with the COCs, was subsequently removed at CAS 23-20-01. (2) The sludge in the concrete box of the catch basin at the large concrete pad at CAS 23-20-01 contained lead and benzo(a)pyrene above the FALs. This contamination was limited to the sludge in the concrete box of the catch basin and did not migrate to the subsurface features beneath it. The contaminated and the concrete box of the catch basin were subsequently recovered at CAS 23-20-01.

  20. Corrective Action Decision Document/Closure Report for Corrective Action Unit 274: Septic Systems, Nevada Test Site, Nevada, Rev. No.: 0

    SciTech Connect

    Grant Evenson

    2006-09-01

    This Corrective Action Decision Document/Closure Report has been prepared for Corrective Action Unit 274, Septic Systems, Nevada Test Site (NTS), Nevada in accordance with the ''Federal Facility Agreement and Consent Order'' (1996). Corrective Action Unit (CAU) 274 is comprised of five corrective action sites (CASs): (1) CAS 03-02-01, WX-6 ETS Building Septic System; (2) CAS 06-02-01, Cesspool; (3) CAS 09-01-01, Spill Site; (4) CAS 09-05-01, Leaching Pit; and (5) CAS 20-05-01, Septic System. The purpose of this Corrective Action Decision Document/Closure Report is to provide justification and documentation supporting the closure of CAU 274 with no further corrective action. To achieve this, corrective action investigation (CAI) activities were performed from November 14 through December 17, 2005 as set forth in the CAU 274 Corrective Action Investigation Plan. The purpose of the CAI was to fulfill the following data needs as defined during the data quality objective (DQO) process: (1) Determine whether contaminants of concern (COCs) are present. (2) If contaminants of concern are present, determine their nature and extent. (3) Provide sufficient information and data to complete appropriate corrective actions. The CAU 274 dataset from the investigation results was evaluated based on the data quality indicator parameters. This evaluation demonstrated the quality and acceptability of the dataset for use in fulfilling the DQO data needs. Analytes detected during the CAI were evaluated against final action levels (FALs) established in this document. No analytes were detected at concentrations exceeding the FALs. No COCs have been released to the soil at CAU 274, and corrective action is not required. Therefore, the DQO data needs were met, and it was determined that no corrective action based on risk to human receptors is necessary for the site. All FALs were calculated using the industrial site worker scenario except for benzo(a)pyrene, which was calculated based on

  1. Corrective Action Decision Document/Closure Report for Corrective Action Unit 561: Waste Disposal Areas, Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Mark Krauss

    2011-08-01

    counterweights were also removed, and the soil below these items does not contain contamination that exceeds the FAL for lead. (4) The concrete-like material at CAS 25-08-02 contains arsenic above the FAL of 23 mg/kg. This concrete-like material was removed, and the soil that remains at this CAS does not contain contamination exceeding the FALs. Lead-acid batteries were also removed, and the soil below the batteries does not contain contamination that exceeds the FAL for lead. (5) The surface soils within the main waste dump at the posted southern radioactive material area (RMA) at CAS 25-23-21 contain cesium (Cs)-137 and PCBs above the FALs of 72.9 picocuries per gram (pCi/g) and 0.74 mg/kg, respectively. The soil was removed from the RMA, and the soil that remains at this CAS does not contain contamination exceeding the FALs. (6) The surface and subsurface soils at CAS 25-25-19 do not contain contamination exceeding the FALs. In addition, lead bricks were removed, and the soil below these items does not contain contamination that exceeds the FAL for lead. The following best management practices were implemented: (1) Housekeeping debris at CASs 02-08-02, 23-21-04, 25-08-02, 25-23-21, and 25-25-19 was removed and disposed of; (2) The open trenches at CAS 23-21-04 were backfilled; (3) The waste piles at CAS 25-08-02 were removed and the area leveled to ground surface; and (4) The remaining waste piles at the main waste dump at CAS 25-23-21 were leveled to ground surface. Therefore, NNSA/NSO provides the following recommendations: (1) No further action for CASs 01-19-01, 03-19-02, 05-62-01, 12-23-09, and 22-19-06; (2) Closure in place with an FFACO use restriction (UR) at CAS 02-08-02 for the remaining PAH-, arsenic-, and lead-contaminated soil, and the melted lead PSM. The UR form and map have been filed in the NNSA/NSO Facility Information Management System, the FFACO database, and the NNSA/NSO CAU/CAS files; (3) No further corrective action at CAS 23-21-04, as the lead bricks

  2. Corrective Action Investigation Plan for Corrective Action Unit 371: Johnnie Boy Crater and Pin Stripe Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews

    2009-02-01

    dose rates exceed final action levels (FALs). • Collect and submit environmental samples for laboratory analysis to determine whether chemical contaminants are present at concentrations exceeding FALs. • If contamination exceeds FALs, define the extent of the contamination exceeding FALs. • Investigate waste to determine whether potential source material is present. This Corrective Action Investigation Plan has been developed in accordance with the Federal Facility Agreement and Consent Order that was agreed to by the State of Nevada; U.S. Department of Energy; and U.S. Department of Defense. Under the Federal Facility Agreement and Consent Order, this Corrective Action Investigation Plan will be submitted to the Nevada Division of Environmental Protection for approval. Fieldwork will be conducted following approval of the plan.

  3. Action and perception at the level of synergies.

    PubMed

    Turvey, M T

    2007-08-01

    Meeting the challenge of assembling coherent organizations of very many muscles characterizes a functional level of biological movement systems referred to as the level of muscular-articular links or synergies. The present article examines the issues confronting the forming, regulating, and ordering of synergies and the hypothesized principles, both classical and contemporary, which resolve them. A primary goal of the article is to highlight the abstractness of the concepts and tools required to understand the level's action-perception competence. Coverage is given to symmetry groups, task space, order parameters, metastability, biotensegrity, allometric scaling, and impredicative definitions. PMID:17604860

  4. Assessing country-level efforts to link research to action.

    PubMed Central

    Lavis, John N.; Lomas, Jonathan; Hamid, Maimunah; Sewankambo, Nelson K.

    2006-01-01

    We developed a framework for assessing country-level efforts to link research to action. The framework has four elements. The first element assesses the general climate (how those who fund research, universities, researchers and users of research support or place value on efforts to link research to action). The second element addresses the production of research (how priority setting ensures that users' needs are identified and how scoping reviews, systematic reviews and single studies are undertaken to address these needs). The third element addresses the mix of four clusters of activities used to link research to action. These include push efforts (how strategies are used to support action based on the messages arising from research), efforts to facilitate "user pull" (how "one-stop shopping" is provided for optimally packaged high-quality reviews either alone or as part of a national electronic library for health, how these reviews are profiled during "teachable moments" such as intense media coverage, and how rapid-response units meet users' needs for the best research), "user pull" efforts undertaken by those who use research (how users assess their capacity to use research and how structures and processes are changed to support the use of research) and exchange efforts (how meaningful partnerships between researchers and users help them to jointly ask and answer relevant questions). The fourth element addresses approaches to evaluation (how support is provided for rigorous evaluations of efforts to link research to action). PMID:16917649

  5. In-cell NMR reveals potential precursor of toxic species from SOD1 fALS mutants

    NASA Astrophysics Data System (ADS)

    Luchinat, Enrico; Barbieri, Letizia; Rubino, Jeffrey T.; Kozyreva, Tatiana; Cantini, Francesca; Banci, Lucia

    2014-11-01

    Mutations in the superoxide dismutase 1 (SOD1) gene are related to familial cases of amyotrophic lateral sclerosis (fALS). Here we exploit in-cell NMR to characterize the protein folding and maturation of a series of fALS-linked SOD1 mutants in human cells and to obtain insight into their behaviour in the cellular context, at the molecular level. The effect of various mutations on SOD1 maturation are investigated by changing the availability of metal ions in the cells, and by coexpressing the copper chaperone for SOD1, hCCS. We observe for most of the mutants the occurrence of an unstructured SOD1 species, unable to bind zinc. This species may be a common precursor of potentially toxic oligomeric species, that are associated with fALS. Coexpression of hCCS in the presence of copper restores the correct maturation of the SOD1 mutants and prevents the formation of the unstructured species, confirming that hCCS also acts as a molecular chaperone.

  6. Streamlined Approach for Environmental Restoration (SAFER) Plan for Corrective Action Unit 540: Spill Sites Nevada Test Site, Nevada, Rev. No.: 0, with Errata

    SciTech Connect

    Pastor, Laura

    2005-11-01

    This Streamlined Approach for Environmental Restoration (SAFER) Plan addresses closure for Corrective Action Unit (CAU) 540, Spill Sites, identified in the ''Federal Facility Agreement and Consent Order''. Corrective Action Unit 540 consists of the nine following Corrective Action Sites (CASs) located in Areas 12 and 19 of the Nevada Test Site: (1) 12-44-01, ER 12-1, Well Site Release; (2) 12-99-01, Oil Stained Dirt; (3) 19-25-02, Oil Spill; (4) 19-25-04, Oil Spill; (5) 19-25-05, Oil Spill; (6) 19-25-06, Oil Spill; (7) 19-25-07, Oil Spill; (8) 19-25-08, Oil Spills (3); and (9) 19-44-03, U-19bf Drill Site Release. This plan provides the methodology for field activities needed to gather the necessary information for closing each CAS. There is sufficient information and process knowledge from historical documentation and investigations of similar sites regarding the expected nature and extent of potential contaminants to recommend closure of CAU 540 using the SAFER process. The data quality objective process developed for this CAU identified the following expected closure options: (1) investigation and confirmation that no contamination exists above the final action levels (FALs), leading to a no further action declaration; (2) characterization of the nature and extent of contamination, leading to closure in place with use restrictions; or (3) clean closure by remediation and verification. The expected closure options were selected based on available information including contaminants of potential concern (COPC), future land use, and assumed risks. A decision flow process was developed to define an approach necessary to achieve closure. There are two decisions that need to be resolved for closure. Decision I is to conduct an investigation to determine whether COPCs are present in concentrations exceeding the FALs. If COPCs are found to be present above FALs, excavation of the contaminated material will occur with the collection of confirmation samples to ensure

  7. Investigation of the low-level modulated light action

    NASA Astrophysics Data System (ADS)

    Antonov, Sergei N.; Sotnikov, V. N.; Koreneva, L. G.

    1994-07-01

    Now there exists no clear complete knowledge about mechanisms and pathways by which low level laser bioactivation works. Modulated laser light action has been investigated two new ways: dynamical infrared thermography and computing image of living brain. These ways permit observation in real time laser action on peripheral blood flow, reflex reactions to functional probes, thermoregulation mechanisms as well as brain electrical activity changes of humans. We have designed a universal apparatus which produced all regimes of the output laser light. It has a built-in He-Ne laser with an acousto-optic modulator and an infrared GaAs laser. The device provided spatial combination of both the light beams and permitted us to irradiate an object both separately and simultaneously. This research shows that the most effective frequencies range from several to dozens of hertz. The duty factor and frequency scanning are also important. On the basis of these results in Russian clinics new treatment methods using modulated light are applied in practical neurology, gynecology, etc.

  8. Maternal and child undernutrition: effective action at national level.

    PubMed

    Bryce, Jennifer; Coitinho, Denise; Darnton-Hill, Ian; Pelletier, David; Pinstrup-Andersen, Per

    2008-02-01

    80% of the world's undernourished children live in just 20 countries. Intensified nutrition action in these countries can lead to achievement of the first Millennium Development Goal (MDG) and greatly increase the chances of achieving goals for child and maternal mortality (MDGs 4 and 5). Despite isolated successes in specific countries or for interventions--eg, iodised salt and vitamin A supplementation--most countries with high rates of undernutrition are failing to reach undernourished mothers and children with effective interventions supported by appropriate policies. This paper reports on an assessment of actions addressing undernutrition in the countries with the highest burden of undernutrition, drawing on systematic reviews and best-practice reports. Seven key challenges for addressing undernutrition at national level are defined and reported on: getting nutrition on the list of priorities, and keeping it there; doing the right things; not doing the wrong things; acting at scale; reaching those in need; data-based decisionmaking; and building strategic and operational capacity. Interventions with proven effectiveness that are selected by countries should be rapidly implemented at scale. The period from pregnancy to 24 months of age is a crucial window of opportunity for reducing undernutrition and its adverse effects. Programme efforts, as well as monitoring and assessment, should focus on this segment of the continuum of care. Nutrition resources should not be used to support actions unlikely to be effective in the context of country or local realities. Nutrition resources should not be used to support actions that have not been proven to have a direct effect on undernutrition, such as stand-alone growth monitoring or school feeding programmes. In addition to health and nutrition interventions, economic and social policies addressing poverty, trade, and agriculture that have been associated with rapid improvements in nutritional status should be

  9. Prediction of the rodent carcinogenicity of organic compounds from their chemical structures using the FALS method.

    PubMed Central

    Moriguchi, I; Hirano, H; Hirono, S

    1996-01-01

    Fuzzy adaptive least-squares (FALS), a pattern recognition method recently developed in our laboratory for correlating structure with activity rating, was used to generate quantitative structure-activity relationship (QSAR) models on the carcinogenicity of organic compounds of several chemical classes. Using the predictive models obtained from the chemical class-based FALS QSAR approach, the rodent carcinogenicity or noncarcinogenicity of a group of organic chemicals currently being tested by the U.S. National Toxicology Program was estimated from their chemical structures. PMID:8933054

  10. 75 FR 47856 - Draft Emergency Action Level Frequently Asked Questions; Request for Comment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-09

    ... COMMISSION Draft Emergency Action Level Frequently Asked Questions; Request for Comment AGENCY: Nuclear.... Nuclear Regulatory Commission (NRC) is making available for comment Emergency Action Level (EAL... pdr.resource@nrc.gov . The ADAMS accession number for the Draft Emergency Action Level...

  11. Oak Ridge Y-12 Plant Emergency Action Level (EAL) Process

    SciTech Connect

    Bailiff, E.G.; Bolling, J.D.

    2000-08-01

    This report establishes requirements and standard methods for the development and maintenance of the Emergency Action Level (EAL) Process used by all lead and event contractors for emergency planning and preparedness. The EAL process ensures a technically defensible approach to emergency categorization/classification in accordance with DOE Order 151.1. The instructions provided in this document include methods and requirements for the development and approval of the EAL process. EALs are developed to cover events inside and outside the Y-12 Plant and to allow the Emergency Response Organization (ERO) to classify or reclassify events promptly based on specific indicators. This report is divided into the following 11 subsections: (1) EAL Process, (2) Categorization/Classification System for Operational Emergencies, (3) Development of EALs, (4) Barrier Analysis for EALs, (5) Symptom-Based and Event-Based EALs, (6) Other Considerations, (7) Integration of EALs with Normal and Off-Normal Operations, (8) EAL Manual, (9) Testing EALs for Completeness, (10) Training and Implementation of EALs, and (11) Configuration Management.

  12. Corrective Action Decision Document/Closure Report for Corrective Action Unit 371: Johnnie Boy Crater and Pin Stripe Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews

    2010-07-01

    This Corrective Action Decision Document/Closure Report has been prepared for Corrective Action Unit 371, Johnnie Boy Crater and Pin Stripe, located within Areas 11 and 18 at the Nevada Test Site, Nevada, in accordance with the Federal Facility Agreement and Consent Order (FFACO). Corrective Action Unit (CAU) 371 comprises two corrective action sites (CASs): • 11-23-05, Pin Stripe Contamination Area • 18-45-01, U-18j-2 Crater (Johnnie Boy) The purpose of this Corrective Action Decision Document/Closure Report is to provide justification and documentation supporting the recommendation that no further corrective action is needed for CAU 371 based on the implementation of corrective actions. The corrective action of closure in place with administrative controls was implemented at both CASs. Corrective action investigation (CAI) activities were performed from January 8, 2009, through February 16, 2010, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 371: Johnnie Boy Crater and Pin Stripe. The approach for the CAI was divided into two facets: investigation of the primary release of radionuclides and investigation of other releases (migration in washes and chemical releases). The purpose of the CAI was to fulfill data needs as defined during the data quality objective (DQO) process. The CAU 371 dataset of investigation results was evaluated based on the data quality indicator parameters. This evaluation demonstrated the dataset is acceptable for use in fulfilling the DQO data needs. Analytes detected during the CAI were evaluated against final action levels (FALs) established in this document. Radiological doses exceeding the FAL of 25 millirem per year were not found to be present in the surface soil. However, it was assumed that radionuclides are present in subsurface media within the Johnnie Boy crater and the fissure at Pin Stripe. Due to the assumption of radiological dose exceeding the FAL, corrective actions were undertaken

  13. Atomic-level Snapshot Catches Protein Motor in Action

    SciTech Connect

    2009-01-01

    Using a state-of-the-art protein crystallography beamline at Berkeley Labs Advanced Light Source, researchers have captured a critical action shapshot of an enzyme that is vital to the survival of all biological cells.

  14. Corrective Action Decision Document/Closure Report for Corrective Action Unit 372: Area 20 Cabriolet/Palanquin Unit Craters, Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Matthews, Patrick and Sloop, Christy

    2011-04-01

    This Corrective Action Decision Document (CADD)/Closure Report (CR) has been prepared for Corrective Action Unit (CAU) 372, Area 20 Cabriolet/Palanquin Unit Craters, located within Areas 18 and 20 at the Nevada National Security Site, Nevada, in accordance with the Federal Facility Agreement and Consent Order (FFACO). Corrective Action Unit 372 comprises four corrective action sites (CASs): • 18-45-02, Little Feller I Surface Crater • 18-45-03, Little Feller II Surface Crater • 20-23-01, U-20k Contamination Area • 20-45-01, U-20L Crater (Cabriolet) The purpose of this CADD/CR is to provide justification and documentation supporting the recommendation that no further corrective action is needed for CAU 372 based on the implementation of the corrective action of closure in place with administrative controls at all CASs. Corrective action investigation (CAI) activities were performed from November 9, 2009, through December 10, 2010, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 372: Area 20 Cabriolet/Palanquin Unit Craters. The approach for the CAI was divided into two facets: investigation of the primary release of radionuclides and investigation of other releases (migration in washes and chemical releases). The purpose of the CAI was to fulfill data needs as defined during the data quality objective (DQO) process. The CAU 372 dataset of investigation results was evaluated based on a data quality assessment. This assessment demonstrated the dataset is acceptable for use in fulfilling the DQO data needs. Investigation results were evaluated against final action levels (FALs) established in this document. A radiological dose FAL was established of 25 millirem per year based on the Remote Work Area exposure scenario (336 hours of annual exposure). Radiological doses exceeding the FAL were found to be present at all four CASs. It is assumed that radionuclide levels present within the Little Feller I and Cabriolet high

  15. Corrective Action Decision Document/Closure Report for Corrective Action Unit 554: Area 23 Release Site Nevada Test Site, Nevada, Rev. No.: 0 with Errata Sheet

    SciTech Connect

    Evenson, Grant

    2005-12-01

    contamination is confined to 12.5 ft bgs to the subsurface media and laterally within approximately 100 ft of the release. (2) A single soil sample collected from the depth of 99 to 100 ft bgs demonstrated the presence of TCE at a concentration above the PAL. (3) Two soil samples collected from depths of 198 to 199 ft bgs and 380 to 382 ft bgs demonstrated the presence of benzo(a)pyrene at a concentration above the PAL. (4) Two soil samples collected from depths of 240 to 241 ft bgs and 290 to 291 ft bgs demonstrated the presence of dibenz(a,h)anthracene at a concentration above the PAL. Tier 2 final action levels (FALs) were then calculated for these contaminants. The Tier 2 FALs for TCE, benzo(a)pyrene, and dibenz(a,h)anthracene were calculated based on a limited exposure to subsurface contamination scenario, and the Tier 2 FAL for TPH-DRO was established as the U.S. Environmental Protection Agency Region 9 Preliminary Remediation Goal values for the individual hazardous constituents of diesel. The evaluation of TPH-DRO, benzo(a)pyrene, dibenz(a,h)anthracene, and TCE based on the Tier 2 FALs determined that no FALs were exceeded. Therefore, the DQO data needs were met, and it was determined that no corrective action (based on risk to human receptors) is necessary for the site.

  16. Dysregulation in level of goal and action identification across psychological disorders

    PubMed Central

    Watkins, Edward

    2011-01-01

    Goals, events, and actions can be mentally represented within a hierarchical framework that ranges from more abstract to more concrete levels of identification. A more abstract level of identification involves general, superordinate, and decontextualized mental representations that convey the meaning of goals, events, and actions, “why” an action is performed, and its purpose, ends, and consequences. A more concrete level of identification involves specific and subordinate mental representations that include contextual details of goals, events, and actions, and the specific “how” details of an action. This review considers three lines of evidence for considering that dysregulation of level of goal/action identification may be a transdiagnostic process. First, there is evidence that different levels of identification have distinct functional consequences and that in non-clinical samples level of goal/action identification appears to be regulated in a flexible and adaptive way to match the level of goal/action identification to circumstances. Second, there is evidence that level of goal/action identification causally influences symptoms and processes involved in psychological disorders, including emotional response, repetitive thought, impulsivity, problem solving and procrastination. Third, there is evidence that the level of goal/action identification is biased and/or dysregulated in certain psychological disorders, with a bias towards more abstract identification for negative events in depression, GAD, PTSD, and social anxiety. PMID:20579789

  17. Dysregulation in level of goal and action identification across psychological disorders.

    PubMed

    Watkins, Edward

    2011-03-01

    Goals, events, and actions can be mentally represented within a hierarchical framework that ranges from more abstract to more concrete levels of identification. A more abstract level of identification involves general, superordinate, and decontextualized mental representations that convey the meaning of goals, events, and actions, "why" an action is performed, and its purpose, ends, and consequences. A more concrete level of identification involves specific and subordinate mental representations that include contextual details of goals, events, and actions, and the specific "how" details of an action. This review considers three lines of evidence for considering that dysregulation of level of goal/action identification may be a transdiagnostic process. First, there is evidence that different levels of identification have distinct functional consequences and that in non-clinical samples level of goal/action identification appears to be regulated in a flexible and adaptive way to match the level of goal/action identification to circumstances. Second, there is evidence that level of goal/action identification causally influences symptoms and processes involved in psychological disorders, including emotional response, repetitive thought, impulsivity, problem solving and procrastination. Third, there is evidence that the level of goal/action identification is biased and/or dysregulated in certain psychological disorders, with a bias towards more abstract identification for negative events in depression, GAD, PTSD, and social anxiety. PMID:20579789

  18. 21 CFR 509.4 - Establishment of tolerances, regulatory limits, and action levels.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., and action levels. 509.4 Section 509.4 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF..., regulatory limits, and action levels. (a) When appropriate under the criteria of § 509.6, a tolerance for an... in subpart B of this part under the provisions of section 406 of the act. A tolerance may...

  19. 21 CFR 109.4 - Establishment of tolerances, regulatory limits, and action levels.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., and action levels. 109.4 Section 109.4 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF..., regulatory limits, and action levels. (a) When appropriate under the criteria of § 109.6, a tolerance for an... in subpart B of this part under the provisions of section 406 of the act. A tolerance may...

  20. 21 CFR 509.4 - Establishment of tolerances, regulatory limits, and action levels.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., and action levels. 509.4 Section 509.4 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF..., regulatory limits, and action levels. (a) When appropriate under the criteria of § 509.6, a tolerance for an... in subpart B of this part under the provisions of section 406 of the act. A tolerance may...

  1. 21 CFR 109.4 - Establishment of tolerances, regulatory limits, and action levels.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., and action levels. 109.4 Section 109.4 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF..., regulatory limits, and action levels. (a) When appropriate under the criteria of § 109.6, a tolerance for an... in subpart B of this part under the provisions of section 406 of the act. A tolerance may...

  2. 21 CFR 509.4 - Establishment of tolerances, regulatory limits, and action levels.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., and action levels. 509.4 Section 509.4 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF..., regulatory limits, and action levels. (a) When appropriate under the criteria of § 509.6, a tolerance for an... in subpart B of this part under the provisions of section 406 of the act. A tolerance may...

  3. 21 CFR 109.4 - Establishment of tolerances, regulatory limits, and action levels.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., and action levels. 109.4 Section 109.4 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF..., regulatory limits, and action levels. (a) When appropriate under the criteria of § 109.6, a tolerance for an... in subpart B of this part under the provisions of section 406 of the act. A tolerance may...

  4. 21 CFR 509.4 - Establishment of tolerances, regulatory limits, and action levels.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., and action levels. 509.4 Section 509.4 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF..., regulatory limits, and action levels. (a) When appropriate under the criteria of § 509.6, a tolerance for an... in subpart B of this part under the provisions of section 406 of the act. A tolerance may...

  5. Climbing the goal ladder: how upcoming actions increase level of aspiration.

    PubMed

    Koo, Minjung; Fishbach, Ayelet

    2010-07-01

    Pursuing a series of progressive (e.g., professional) goals that form a goal ladder often leads to a trade-off between moving up to a more advanced level and repeating the same goal level. This article investigates how monitoring one's current goal in terms of remaining actions versus completed actions influences the desire to move up the goal ladder. The authors propose that a focus on remaining (vs. completed) actions increases the motivation to move up to a more advanced level, whereas the focus on completed (vs. remaining) actions increases the satisfaction derived from the present level. They find support for these predictions across several goal ladders, ranging from academic and professional ladders to simple, experimental tasks. They further find that individuals strategically attend to information about remaining (vs. completed) actions to prepare to move up the goal ladder. PMID:20565182

  6. Building Effective Middle Level Teams. Turning Points: Recommendations into Action.

    ERIC Educational Resources Information Center

    Hirsh, Stephanie; Valentine, Jerry W.

    This booklet is the first in a series of monographs developed as a resource for middle-level leaders. It provides practical strategies, procedures, and ideas to enable school leaders to plan and implement programs that will provide opportunities for students to be prepared for high school and beyond. The text focuses on the application of team…

  7. Corrective Action Decision Document/Closure Report for Corrective Action Unit 374: Area 20 Schooner Unit Crater, Nevada National Security Site, Nevada with ROTC 1, Revision 0

    SciTech Connect

    Patrick Matthews

    2011-07-01

    Corrective Action Unit 374 comprises five corrective action sites (CASs): • 18-22-05, Drum • 18-22-06, Drums (20) • 18-22-08, Drum • 18-23-01, Danny Boy Contamination Area • 20-45-03, U-20u Crater (Schooner) The purpose of this Corrective Action Decision Document/Closure Report is to provide justification and documentation supporting the recommendation that no further corrective action is needed for CAU 374 based on the implementation of corrective actions. The corrective action of closure in place with administrative controls was implemented at CASs 18-23-01 and 20-45-03, and a corrective action of removing potential source material (PSM) was conducted at CAS 20-45-03. The other CASs require no further action; however, best management practices of removing PSM and drums at CAS 18-22-06, and removing drums at CAS 18-22-08 were performed. Corrective action investigation (CAI) activities were performed from May 4 through October 6, 2010, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 374: Area 20 Schooner Unit Crater, Nevada Test Site, Nevada. The approach for the CAI was divided into two facets: investigating the primary release of radionuclides and investigating other releases (migration in washes and chemical releases). The purpose of the CAI was to fulfill data needs as defined during the data quality objective (DQO) process. The CAU 374 dataset of investigation results was evaluated based on the data quality indicator parameters. This evaluation demonstrated the dataset is acceptable for use in fulfilling the DQO data needs. Analytes detected during the CAI were evaluated against final action levels (FALs) established in this document. Radiological doses exceeding the FAL of 25 millirem per year were found to be present in the surface soil that was sampled. It is assumed that radionuclide levels present in subsurface media within the craters and ejecta fields (default contamination boundaries) at the Danny Boy and

  8. Proposed actions are no actions: re-modeling an ontology design pattern with a realist top-level ontology

    PubMed Central

    2012-01-01

    Background Ontology Design Patterns (ODPs) are representational artifacts devised to offer solutions for recurring ontology design problems. They promise to enhance the ontology building process in terms of flexibility, re-usability and expansion, and to make the result of ontology engineering more predictable. In this paper, we analyze ODP repositories and investigate their relation with upper-level ontologies. In particular, we compare the BioTop upper ontology to the Action ODP from the NeOn an ODP repository. In view of the differences in the respective approaches, we investigate whether the Action ODP can be embedded into BioTop. We demonstrate that this requires re-interpreting the meaning of classes of the NeOn Action ODP in the light of the precepts of realist ontologies. Results As a result, the re-design required clarifying the ontological commitment of the ODP classes by assigning them to top-level categories. Thus, ambiguous definitions are avoided. Classes of real entities are clearly distinguished from classes of information artifacts. The proposed approach avoids the commitment to the existence of unclear future entities which underlies the NeOn Action ODP. Our re-design is parsimonious in the sense that existing BioTop content proved to be largely sufficient to define the different types of actions and plans. Conclusions The proposed model demonstrates that an expressive upper-level ontology provides enough resources and expressivity to represent even complex ODPs, here shown with the different flavors of Action as proposed in the NeOn ODP. The advantage of ODP inclusion into a top-level ontology is the given predetermined dependency of each class, an existing backbone structure and well-defined relations. Our comparison shows that the use of some ODPs is more likely to cause problems for ontology developers, rather than to guide them. Besides the structural properties, the explanation of classification results were particularly hard to grasp for

  9. Using Action Research in Middle Level Teacher Education to Evaluate and Deepen Reflective Practice

    ERIC Educational Resources Information Center

    Hagevik, Rita; Aydeniz, Mehmet; Rowell, C. Glennon

    2012-01-01

    The study examined the role of action research in promoting critical reflective thinking among twenty preservice teachers engaged in a year-long middle level program. Data from collaborative discussions, final written documents, presentations, and follow-up surveys revealed that conducting action research (a) engaged them in inquiry into their own…

  10. 42 CFR 493.1816 - Action when deficiencies are not at the condition level.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Action when deficiencies are not at the condition level. 493.1816 Section 493.1816 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Enforcement Procedures § 493.1816 Action when...

  11. The WldS gene modestly prolongs survival in the SOD1G93A fALS mouse.

    PubMed

    Fischer, Lindsey R; Culver, Deborah G; Davis, Albert A; Tennant, Philip; Wang, Minsheng; Coleman, Michael; Asress, Seneshaw; Adalbert, Robert; Alexander, Guillermo M; Glass, Jonathan D

    2005-01-01

    The "slow Wallerian degeneration" (Wld(S)) gene is neuroprotective in numerous models of axonal degeneration. Axonal degeneration is an early feature of disease progression in the SOD1G93A mouse, a widely used model of familial amyotrophic lateral sclerosis (fALS). We crossed the Wld(S) mouse with the SOD1G93A mouse to investigate whether the Wld(S) gene could prolong survival and modify neuropathology in these mice. SOD/Wld(S) mice showed levels of motor axon loss similar to that seen in SOD1G93A mice. The presence of the Wld(S) gene, however, modestly prolonged survival and delayed denervation at the neuromuscular junction. Prolonged survival was more prominent in female mice and did not depend on whether animals were heterozygous or homozygous for the Wld(S) gene. We also report that SOD1G93A mice show significant degeneration of sensory axons during the course of disease, supporting previous data from humans demonstrating that ALS is not purely a motor disorder. PMID:15837585

  12. 77 FR 63355 - Proposed Revision to Emergency Action Level Development Guidance Document

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ...The U.S. Nuclear Regulatory Commission (NRC or the Commission) is making available for comment a proposed revision to the Nuclear Energy Institute (NEI) 99-01, proposed Revision 6, ``Development of Emergency Action Levels for Non-Passive Reactors,'' dated September 2012. This document is intended to be used by the industry in the development of an emergency action level (EAL) scheme. The NRC......

  13. Corrective Action Investigation Plan for Corrective Action Unit 571: Area 9 Yucca Flat Plutonium Dispersion Sites, Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Bailey, Bernadine; Matthews, Patrick

    2013-07-01

    CAU 571 is a grouping of sites where there has been a suspected release of contamination associated with nuclear testing. This document describes the planned investigation of CAU 571, which comprises the following corrective action sites (CASs): • 09-23-03, Atmospheric Test Site S-9F • 09-23-04, Atmospheric Test Site T9-C • 09-23-12, Atmospheric Test Site S-9E • 09-23-13, Atmospheric Test Site T-9D • 09-45-01, Windrows Crater These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable CAAs that will be presented in the investigation report. The sites will be investigated based on the data quality objectives (DQOs) developed on March 6, 2013, by representatives of the Nevada Division of Environmental Protection and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (now the Nevada Field Office). The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 571. The site investigation process will also be conducted in accordance with the Soils Activity Quality Assurance Plan, which establishes requirements, technical planning, and general quality practices to be applied to this activity. The potential contamination sources associated with CAU 571 CASs are from nuclear testing activities. The DQO process resulted in an assumption that total effective dose (TED) within a default contamination boundary exceeds the final action level (FAL) and requires corrective action. The presence and nature of contamination outside the default

  14. From action representation to action execution: exploring the links between cognitive and biomechanical levels of motor control

    PubMed Central

    Land, William M.; Volchenkov, Dima; Bläsing, Bettina E.; Schack, Thomas

    2013-01-01

    Along with superior performance, research indicates that expertise is associated with a number of mediating cognitive adaptations. To this extent, extensive practice is associated with the development of general and task-specific mental representations, which play an important role in the organization and control of action. Recently, new experimental methods have been developed, which allow for investigating the organization and structure of these representations, along with the functional structure of the movement kinematics. In the current article, we present a new approach for examining the overlap between skill representations and motor output. In doing so, we first present an architecture model, which addresses links between biomechanical and cognitive levels of motor control. Next, we review the state of the art in assessing memory structures underlying complex action. Following we present a new spatio-temporal decomposition method for illuminating the functional structure of movement kinematics, and finally, we apply these methods to investigate the overlap between the structure of motor representations in memory and their corresponding kinematic structures. Our aim is to understand the extent to which the output at a kinematic level is governed by representations at a cognitive level of motor control. PMID:24065915

  15. Corrective Action Decision Document/Closure Report for Corrective Action Unit 482: Area 15 U15a/e Muckpiles and Ponds Nevada Test Site

    SciTech Connect

    NSTec Environmental Restoration

    2009-09-30

    This Corrective Action Decision Document /Closure Report (CADD/CR) was prepared by the Defense Threat Reduction Agency (DTRA) for Corrective Action Unit (CAU) 482 U15a/e Muckpiles and Ponds. This CADD/CR is consistent with the requirements of the Federal Facility Agreement and Consent Order agreed to by the State of Nevada, the U.S. Department of Energy, and the U.S. Department of Defense. Corrective Action Unit 482 is comprised of three Corrective Action Sites (CASs) and one adjacent area: CAS 15-06-01, U15e Muckpile; CAS 15-06-02, U15a Muckpile; CAS 15-38-01, Area 15 U15a/e Ponds; and Drainage below the U15a Muckpile. The purpose of this CADD/CR is to provide justification and documentation supporting the recommendation for closure with no further corrective action, by placing use restrictions on the three CASs and the adjacent area of CAU 482. To support this recommendation, a corrective action investigation (CAI) was performed in September 2002. The purpose of the CAI was to fulfill the following data needs as defined during the Data Quality Objective (DQO) process: (1) Determine whether contaminants of concern (COCs) are present. (2) If COCs are present, determine their nature and extent. (3) Provide sufficient information and data to determine appropriate corrective actions. The CAU 482 dataset from the CAI was evaluated based on the data quality indicator parameters. This evaluation demonstrated the quality and acceptability of the dataset for use in fulfilling the DQO data needs. Analytes detected during the CAI were evaluated against final action levels (FALs) established in this document. Tier 2 FALS were determined for the hazardous constituents of total petroleum hydrocarbons (TPH)-diesel-range organics (DRO) and the radionuclides americium (Am)-241, cesium (Cs)-137, plutonium (Pu)-238, and Pu-239. The Tier 2 FALs were calculated for the radionuclides using site-specific information. The hazardous constituents of TPH-DRO were compared to the PALs

  16. The neural basis of conceptualizing the same action at different levels of abstraction.

    PubMed

    Spunt, Robert P; Kemmerer, David; Adolphs, Ralph

    2016-07-01

    People can conceptualize the same action (e.g. 'riding a bike') at different levels of abstraction (LOA), where higher LOAs specify the abstract motives that explain why the action is performed (e.g. 'getting exercise'), while lower LOAs specify the concrete steps that indicate how the action is performed (e.g. 'gripping handlebars'). Prior neuroimaging studies have shown that why and how questions about actions differentially activate two cortical networks associated with mental-state reasoning and action representation, respectively; however, it remains unknown whether this is due to the differential demands of the questions per se or to the shifts in LOA those questions produce. We conducted functional magnetic resonance imaging while participants judged pairs of action phrases that varied in LOA and that could be framed either as a why question (Why ride a bike? Get exercise.) or a how question (How to get exercise? Ride a bike.). Question framing (why vs how) had no effect on activity in regions of the two networks. Instead, these regions uniquely tracked parametric variation in LOA, both across and within trials. This suggests that the human capacity to understand actions at different LOA is based in the relative activity of two cortical networks. PMID:26117505

  17. Action recognition by mid-level discriminative spatial-temporal volume

    NASA Astrophysics Data System (ADS)

    Chen, Feifei; Sang, Nong

    2013-10-01

    Most of recent work on action recognition in video employ action parts, attributes etc. as mid- and high-level features to represent an action. However, these action parts, attributes subject to some aspects of weak discrimination and being difficult to obtain. In this paper, we present an approach that uses mid-level discriminative Spatial-Temporal Volume to recognize human actions. The spatial-temporal volume is represented by a Feature Graph which is constructed beyond on a local collection of feature points (e.g., cuboids, STIP) located in the corresponding spatial-temporal volume. Firstly, we densely sampling spatial-temporal volumes from training videos and construct a feature graph for each volume. Then, all feature graphs are clustered using spectral cluster method. We regard feature graphs as video words and characterize videos with the bag-of-features framework which we call it the bag-of-feature-graphs framework. While, in the process of clustering, the distance between two feature graphs is computed using an efficient spectral method. Final recognition is accomplished using a linear-SVM classifier. We test our algorithm in a publicly available human action dataset, the experimental results show the effectiveness of our method.

  18. An Action Science Research Approach to Reducing Student Tardiness at the High School Level

    ERIC Educational Resources Information Center

    Gile, Curtis S.

    2013-01-01

    The purpose of this action research study was to design, implement, analyze, and evaluate a series of interventions to reduce student tardiness at the high school level. Another purpose of the study was to determine the underlying values, beliefs, and behaviors associated with student tardiness from a faculty and staff perspective. The study…

  19. Use of screening action levels in risk management at Los Alamos National Laboratory

    SciTech Connect

    Beck, J.R.; Hueske, K.L.; Dorries, A.M.

    1994-04-01

    The screening assessment approach used at Los Alamos National Laboratory has proved to be a valuable risk management tool in making decisions that are cost-effective, efficient, and defensible. Los Alamos has successfully used screening action levels to prioritize RFI activities, streamline data evaluation, and insure analytical methods are adequately sensitive to be protective of human health.

  20. 5 CFR 351.603 - Actions subsequent to release from competitive level.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... SERVICE REGULATIONS REDUCTION IN FORCE Release From Competitive Level § 351.603 Actions subsequent to... assignment to another position in accordance with subpart G of this part. If the employee accepts, the... accept an offer under subpart G, the employee shall be furloughed or separated....

  1. 5 CFR 351.603 - Actions subsequent to release from competitive level.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... SERVICE REGULATIONS REDUCTION IN FORCE Release From Competitive Level § 351.603 Actions subsequent to... assignment to another position in accordance with subpart G of this part. If the employee accepts, the... accept an offer under subpart G, the employee shall be furloughed or separated....

  2. 75 FR 6064 - Draft Emergency Action Level Frequently Asked Questions; Request for Comment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-05

    ...The U.S. Nuclear Regulatory Commission (NRC) is making available for comment an Emergency Action Level (EAL) frequently asked question (FAQ). This EALFAQ will be used to provide clarification of endorsed Nuclear Energy Institute (NEI) guidance related to the development of security related EALs. This EALFAQ was developed by the NRC at the request of NEI. The NRC is publishing this preliminary......

  3. 21 CFR 109.4 - Establishment of tolerances, regulatory limits, and action levels.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Establishment of tolerances, regulatory limits, and action levels. 109.4 Section 109.4 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION UNAVOIDABLE CONTAMINANTS IN FOOD...

  4. 21 CFR 509.4 - Establishment of tolerances, regulatory limits, and action levels.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Establishment of tolerances, regulatory limits, and action levels. 509.4 Section 509.4 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS UNAVOIDABLE...

  5. Corrective Action Decision Document/Closure Report for Corrective Action Unit 367: Area 10 Sedan, Ess and Uncle Unit Craters Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews

    2011-06-01

    investigation results was evaluated based on a data quality assessment. This assessment demonstrated the dataset is complete and acceptable for use in fulfilling the DQO data needs. Analytes detected during the CAI were evaluated against final action levels (FALs) established in this document. For the primary release, radiological doses exceeding the FAL of 25 millirem per year were not found to be present in the surface or shallow subsurface soil outside the default contamination boundary. However, it was assumed that radionuclides are present in subsurface media within each of the three craters (Sedan, Ess, and Uncle) due to prompt injection of radionuclides from the tests. Based on the assumption of radiological dose exceeding the FAL, corrective actions were undertaken that consisted of implementing a use restriction and posting warning signs at each crater CAS. These use restrictions were recorded in the FFACO database; the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) Facility Information Management System; and the NNSA/NSO CAU/CAS files. With regard to other releases, no contaminants of concern were identified at the mud pits or any of the other release locations, with one exception. Potential source material in the form of lead was found at one location. A corrective action of clean closure was implemented at this location, and verification samples indicated that no further action is necessary. Therefore, NNSA/NSO provides the following recommendations: • A Notice of Completion to NNSA/NSO is requested from the Nevada Division of Environmental Protection for closure of CAU 367. • Corrective Action Unit 367 should be promoted from Appendix III to Appendix IV of the FFACO.

  6. Closure Report for Corrective Action Unit 574: Neptune, Nevada National Security Site, Nevada

    SciTech Connect

    NSTec Environmental Restoration

    2012-04-30

    Corrective Action Unit (CAU) 574 is identified in the Federal Facility Agreement and Consent Order (FFACO) as 'Neptune' and consists of the following two Corrective Action Sites (CASs), located in Area 12 of the Nevada National Security Site: (1) CAS 12-23-10, U12c.03 Crater (Neptune); and (2) CAS 12-45-01, U12e.05 Crater (Blanca). This Closure Report presents information supporting closure of CAU 574 according to the FFACO (FFACO, 1996 [as amended March 2010]) and the Streamlined Approach for Environmental Restoration Plan for CAU 574 (U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office [NNSA/NSO], 2011). The following activities were performed to support closure of CAU 574: (1) In situ external dose rate measurements were collected using thermoluminescent dosimeters at CAS 12-45-01, U12e.05 Crater (Blanca). (2) Total effective dose rates were determined at both sites by summing the internal and external dose rate components. (3) A use restriction (UR) was implemented at CAS 12-23-10, U12c.03 Crater (Neptune). Areas that exceed the final action level (FAL) of 25 millirems per year (mrem/yr) based on the Occasional Use Area exposure scenario are within the existing use restricted area for CAU 551. The 25-mrem/yr FAL is not exceeded outside the existing CAU 551 UR for any of the exposure scenarios (Industrial Area, Remote Work Area, and Occasional Use Area). Therefore, the existing UR for CAU 551 is sufficient to bound contamination that exceeds the FAL. (4) An administrative UR was implemented at CAS 12-45-01, U12e.05 Crater (Blanca) as a best management practice (BMP). The 25-mrem/yr FAL was not exceeded for the Remote Work Area or Occasional Use Area exposure scenarios; therefore, a UR is not required. However, because the 25-mrem/yr FAL was exceeded for the Industrial Area exposure scenario, an administrative UR was established as a BMP. UR documentation is included as Appendix B. The UR at CAS 12-23-10, U12c.03 Crater (Neptune

  7. Closure Report for Corrective Action Unit 539: Areas 25 and 26 Railroad Tracks Nevada National Security Site, Nevada with ROTC-1, Revision 0

    SciTech Connect

    Mark Kauss

    2011-06-01

    , 2010, through May 2, 2011, closure activities were performed as set forth in the Streamlined Approach for Environmental Restoration (SAFER) Plan for Corrective Action Unit 539: Areas 25 and 26 Railroad Tracks, Nevada Test Site, Nevada. The purposes of the activities as defined during the data quality objectives process were as follows: • Determine whether contaminants of concern (COCs) are present. • If COCs are present, determine their nature and extent, implement appropriate corrective actions, and properly dispose of wastes. Analytes detected during the closure activities were evaluated against final action levels (FALs) to determine COCs for CAU 539. Assessment of the data generated from closure activities revealed the following: • At CAS 26-99-05, the total effective dose for radiological releases did not exceed the FAL of 25 millirem per Industrial Area year. Potential source material in the form of lead bricks was found at three locations. A corrective action of clean closure was implemented at these locations, and verification samples indicated that no further action is necessary. • At CAS 25-99-21, the total effective dose for radiological releases exceeds the FAL of 25 millirem per Industrial Area year. Potential source material in the form of lead bricks was found at eight locations. A corrective action was implemented by removing the lead bricks and soil above FALs at these locations, and verification samples indicated that no further action is necessary. Pieces of debris with high radioactivity were identified as PSM and remain within the CAS boundary. A corrective action of closure in place with a UR was implemented at this CAS because closure activities showed evidence of remaining soil contamination and radioactive PSM. Future land use will be restricted from surface and intrusive activities. Closure activities generated waste streams consisting of industrial solid waste, recyclable materials, low-level radioactive waste, and mixed low-level

  8. Corrective Action Plan for Corrective Action Unit 366: Area 11 Plutonium Valley Dispersion Sites, Nevada National Security Site, Nevada

    SciTech Connect

    2013-04-30

    This Corrective Action Plan has been prepared for Corrective Action Unit (CAU) 366, Area 11 Plutonium Valley Dispersion Sites, in accordance with the Federal Facility Agreement and Consent Order (FFACO, 1996 as amended). CAU 366 consists of the following six Corrective Action Sites (CASs) located in Area 11 of the Nevada National Security Site: · CAS 11-08-01, Contaminated Waste Dump #1 · CAS 11-08-02, Contaminated Waste Dump #2 · CAS 11-23-01, Radioactively Contaminated Area A · CAS 11-23-02, Radioactively Contaminated Area B · CAS 11-23-03, Radioactively Contaminated Area C · CAS 11-23-04, Radioactively Contaminated Area D Site characterization activities were performed in 2011 and 2012, and the results are presented in Appendix A of the Corrective Action Decision Document (CADD) for CAU 366 (U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office [NNSA/NSO], 2012a). The following closure alternatives were recommended in the CADD: · No further action for CAS 11-23-01 · Closure in place for CASs 11-08-01, 11-08-02, 11-23-02, 11-23-03, and 11-23-04 The scope of work required to implement the recommended closure alternatives includes the following: · Non-engineered soil covers approximately 3 feet thick will be constructed at CAS 11-08-01 over contaminated waste dump (CWD) #1 and at CAS 11-08-02 over CWD #2. · FFACO use restrictions (URs) will be implemented for the areas where the total effective dose (TED) exceeds the final action level (FAL) of 25 millirems per Occasional Use Area year (mrem/OU-yr). The FAL is based on an assumption that the future use of the site includes occasional work activities and that workers will not be assigned to the area on a regular basis. A site worker under this scenario is assumed to be on site for a maximum of 80 hours per year for 5 years. The FFACO UR boundaries will encompass the areas where a worker would be exposed to 25 millirems of radioactivity per year if they are present for 80

  9. Closure Report for Corrective Action Unit 566: EMAD Compound, Nevada National Security Site, Nevada with ROTC-1, Revision 0

    SciTech Connect

    Mark Krauss

    2011-06-01

    This Closure Report (CR) presents information supporting the closure of Corrective Action Unit (CAU) 566: EMAD Compound, Nevada National Security Site, Nevada. Corrective Action Unit 566 comprises Corrective Action Site (CAS) 25-99-20, EMAD Compound, located within Area 25 of the Nevada National Security Site. The purpose of this CR is to provide documentation supporting the completed corrective actions and provide data confirming that the closure objectives for CAU 566 were met. To achieve this, the following actions were performed: • Review the current site conditions, including the concentration and extent of contamination. • Implement any corrective actions necessary to protect human health and the environment. • Properly dispose of corrective action and investigation wastes. • Document Notice of Completion and closure of CAU 566 issued by the Nevada Division of Environmental Protection. From October 2010 through May 2011, closure activities were performed as set forth in the Streamlined Approach for Environmental Restoration Plan for CAU 566: EMAD Compound, Nevada National Security Site, Nevada. The purposes of the activities as defined during the data quality objectives process were as follows: • Determine whether contaminants of concern (COCs) are present. • If COCs are present, determine their nature and extent, implement appropriate corrective actions, and properly dispose of wastes. Analytes detected during the closure activities were evaluated against final action levels (FALs) to determine COCs for CAU 566. Assessment of the data from collected soil samples, and from radiological and visual surveys of the site, indicates the FALs were exceeded for polychlorinated biphenyls (PCBs), semivolatile organic compounds (SVOCs), and radioactivity. Corrective actions were implemented to remove the following: • Radiologically contaminated soil assumed greater than FAL at two locations • Radiologically contaminated soil assumed greater than FAL with

  10. Development of action levels for MED/MPD skin-testing units in ultraviolet phototherapy

    NASA Astrophysics Data System (ADS)

    O'Connor, Una M.; O'Hare, Neil J.

    2003-03-01

    Ultraviolet (UV) Phototherapy is commonly used for treatment of skin diseases such as psoriasis and eczema. Treatment is carried out using UV phototherapy units, exposing all or part of the body for a certain exposure time. Prior to exposure in treatment units, an unaffected area of skin may be tested using UV skin-testing units in order to determine a suitable treatment regime. The exposure time at which barely perceptible erythema has developed is known as the Minimal Erythemal Dose (MED) for UVB therapy and Minimal Phototoxic Dose (MPD) for UVA therapy. This is used to determine the starting dose in the treatment regime. The presence of 'hotspots' and 'coldspots' in UV skin-testing units can result in inaccurate determination of MED/MPD. This could give rise to severe burns during treatment, or in a sub-optimal dose regime being used. Quality assurance protocols for UV phototherapy equipment have recently been developed and these protocols have highlighted the need for action levels for skin-testing units. An action level is a reference value, which is used to determine whether the difference in irradiance output level across a UV unit is acceptable. Current methodologies for skin-testing in Ireland have been characterised and errors introduced during testing have been estimated. Action levels have been developed based on analysis of errors and requirements of skin-testing.

  11. Risk newsboy: approach for addressing uncertainty in developing action levels and cleanup limits

    SciTech Connect

    Cooke, Roger; MacDonell, Margaret

    2007-07-01

    Site cleanup decisions involve developing action levels and residual limits for key contaminants, to assure health protection during the cleanup period and into the long term. Uncertainty is inherent in the toxicity information used to define these levels, based on incomplete scientific knowledge regarding dose-response relationships across various hazards and exposures at environmentally relevant levels. This problem can be addressed by applying principles used to manage uncertainty in operations research, as illustrated by the newsboy dilemma. Each day a newsboy must balance the risk of buying more papers than he can sell against the risk of not buying enough. Setting action levels and cleanup limits involves a similar concept of balancing and distributing risks and benefits in the face of uncertainty. The newsboy approach can be applied to develop health-based target concentrations for both radiological and chemical contaminants, with stakeholder input being crucial to assessing 'regret' levels. Associated tools include structured expert judgment elicitation to quantify uncertainty in the dose-response relationship, and mathematical techniques such as probabilistic inversion and iterative proportional fitting. (authors)

  12. Corrective Action Decision Document for Corrective Action Unit 151: Septic Systems and Discharge Area, Nevada Test Site, Nevada, Rev. No.: 0

    SciTech Connect

    Grant Evenson

    2006-05-01

    This Corrective Action Decision Document has been prepared for Corrective Action Unit (CAU) 151, Septic Systems and Discharge Area, at the Nevada Test Site, Nevada, according to the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996). Corrective Action Unit 151 is comprised of eight corrective action sites (CASs): (1) CAS 02-05-01, UE-2ce Pond; (2) CAS 12-03-01, Sewage Lagoons (6); (3) CAS 12-04-01, Septic Tanks; (4) CAS 12-04-02, Septic Tanks; (5) CAS 12-04-03, Septic Tank; (6) CAS 12-47-01, Wastewater Pond; (7) CAS 18-03-01, Sewage Lagoon; and (8) CAS 18-99-09, Sewer Line (Exposed). The purpose of this Corrective Action Decision Document is to identify and provide the rationale for the recommendation of corrective action alternatives (CAAs) for each of the eight CASs within CAU 151. Corrective action investigation (CAI) activities were performed from September 12 through November 18, 2005, as set forth in the CAU 151 Corrective Action Investigation Plan and Record of Technical Change No. 1. Additional confirmation sampling was performed on December 9, 2005; January 10, 2006; and February 13, 2006. Analytes detected during the CAI were evaluated against appropriate final action levels (FALs) to identify the contaminants of concern for each CAS. The results of the CAI identified contaminants of concern at two of the eight CASs in CAU 151 and required the evaluation of CAAs. Assessment of the data generated from investigation activities conducted at CAU 151 revealed the following: (1) Soils at CASs 02-05-01, 12-04-01, 12-04-02, 12-04-03, 12-47-01, 18-03-01, 18-99-09, and Lagoons B through G of CAS 12-03-01 do not contain contamination at concentrations exceeding the FALs. (2) Lagoon A of CAS 12-03-01 has arsenic above FALs in shallow subsurface soils. (3) One of the two tanks of CAS 12-04-01, System No.1, has polychlorinated biphenyls (aroclor-1254), trichloroethane, and cesium-137 above FALs in the sludge. Both CAS 12-04-01, System No.1 tanks contain

  13. [Comparative antioxidant action on the level of reactive oxygen species in normal and transformed fibroblasts].

    PubMed

    Liublinskaia, O G; Kirpichnikova, K M; Gamaleĭ, I A

    2013-01-01

    We studied the changes in the level of reactive oxygen species (ROS) in normal (3T3) and transformed (3T3-SV40) murine fibroblasts under the antioxidant action for 15 min using fluorescent probe carbo- xy-H2DCFDA. We have shown that N-acetylcysteine (NAC) decreased ROS level in both cellular types. Another antioxidant, alpha-lipoic acid (ALA), and its reduced form, dihydrolipoic acid (DHLA), caused the prooxidant effects. Both ALA and DHLA in the concentration range of 0.1-1.25 mM increased ROS level in dose dependent manner in both cellular types. The ability of ALA and DHLA to activate hydrogen peroxide production is discussed. PMID:25509127

  14. Opportunities for State-Level Action to Reduce Firearm Violence: Proceeding From the Evidence

    PubMed Central

    Braga, Anthony A.

    2011-01-01

    Firearm violence remains an important problem, and a large body of evidence shows that guns used in crime follow generally predictable paths from manufacturer to criminal end user. Policy initiatives based on that evidence have been shown to be effective. A recently published study conducted by a leading policy organization presents new evidence and makes specific recommendations for action by state-level policymakers. Unfortunately, the study's analysis is overly simplified, and the recommendations are therefore misleading. We suggest alternatives that are evidence based. PMID:21778510

  15. Corrective Action Decision Document/Closure Report for Corrective Action Unit 554: Area 23 Release Site Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Evenson, Grant

    2005-07-01

    contamination is confined to 12.5 ft bgs to the subsurface media and laterally within approximately 100 ft of the release. (2) A single soil sample collected from the depth of 99 to 100 ft bgs demonstrated the presence of TCE at a concentration above the PAL. (3) Two soil samples collected from depths of 198 to 199 ft bgs and 380 to 382 ft bgs demonstrated the presence of benzo(a)pyrene at a concentration above the PAL. (4) Two soil samples collected from depths of 240 to 241 ft bgs and 290 to 291 ft bgs demonstrated the presence of dibenz(a,h)anthracene at a concentration above the PAL. Tier 2 final action levels (FALs) were then calculated for these contaminants. The Tier 2 FALs for TCE, benzo(a)pyrene, and dibenz(a,h)anthracene were calculated based on a limited exposure to subsurface contamination scenario, and the Tier 2 FAL for TPH-DRO was established as the U.S. Environmental Protection Agency Region 9 Preliminary Remediation Goal values for the individual hazardous constituents of diesel. The evaluation of TPH-DRO, benzo(a)pyrene, dibenz(a,h)anthracene, and TCE based on the Tier 2 FALs determined that no FALs were exceeded. Therefore, the DQO data needs were met, and it was determined that no corrective action (based on risk to human receptors) is necessary for the site. As a best management practice for the remaining subsurface diesel contamination present at the site, a use restriction was imposed on future site activities that would not allow for future contact of the subsurface contamination. Therefore, the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office provides the following recommendations: (1) No further corrective action for CAU 554. (2) No Corrective Action Plan. (3) A Notice of Completion to the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office is requested from the Nevada Division of Environmental Protection for closure of CAU 554. (4) Corrective Action Unit 554 should be moved from

  16. Taking Action: A Cross-Modal Investigation of Discourse-Level Representations

    PubMed Central

    Kaiser, Elsi

    2012-01-01

    Segmenting stimuli into events and understanding the relations between those events is crucial for understanding the world. For example, on the linguistic level, successful language use requires the ability to recognize semantic coherence relations between events (e.g., causality, similarity). However, relatively little is known about the mental representation of discourse structure. We report two experiments that used a cross-modal priming paradigm to investigate how humans represent the relations between events. Participants repeated a motor action modeled by the experimenter (e.g., rolled a ball toward mini bowling pins to knock them over), and then completed an unrelated sentence-continuation task (e.g., provided a continuation for “Peter scratched John.…”). In two experiments, we tested whether and how the coherence relations represented by the motor actions (e.g., causal events vs. non-causal events) influence participants’ performance in the linguistic task. (A production study was also conducted to explore potential syntactic priming effects.) Our analyses focused on the coherence relations between the prompt sentences and participants’ continuations, as well as the referential shifts in the continuations. As a whole, the results suggest that the mental representations activated by motor actions overlap with the mental representations used during linguistic discourse-level processing, but nevertheless contain fine-grained information about sub-types of causality (reaction vs. consequence). In addition, the findings point to parallels between shifting one’s attention from one-event to another and shifting one’s attention from one referent to another, and indicate that the event structure of causal sequences is conceptualized more like single events than like two distinct events. As a whole, the results point toward common representations activated by motor sequences and discourse-semantic relations, and further our understanding of the mental

  17. Addendum to the Corrective Action Decision Document/Closure Report for Corrective Action Unit 321: Area 22 Weather Station Fuel Storage Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Lynn Kidman

    2008-10-01

    This document constitutes an addendum to the August 2001, Corrective Action Decision Document / Closure Report for Corrective Action Unit 321: Area 22 Weather Station Fuel Storage as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the UR for CAS 22-99-05, Fuel Storage Area. This UR was established as part of a Federal Facility Agreement and Consent Order (FFACO) corrective action and is based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since this UR was established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, this UR was re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the UR) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove the UR because

  18. Ethical issues in using children's blood lead levels as a remedial action objective.

    PubMed

    Moodie, Sue M; Evans, Emily Lorraine

    2011-12-01

    The Environmental Protection Agency measures the success or failure of Superfund site remediation efforts against remedial action objectives (RAOs). RAOs are frequently based on environmental contaminant concentrations, but with lead exposure, blood lead levels from the population at risk are often used. Although childhood lead screening is an important public health tool, an RAO based on child blood lead levels raises ethical concerns: public health efforts that are more reactive than preventive, a blood lead standard (10 μg/dL) that may not be fully protective, the use of a measure whose validity and reliability may be easily compromised, and exacerbation of environmental injustice and systematic disadvantages. The example of Bunker Hill mine, Kellogg, Idaho, allowed an examination of these ethical concerns. PMID:21836120

  19. The study of hydrogen peroxide level under cisplatin action using genetically encoded sensor hyper

    NASA Astrophysics Data System (ADS)

    Belova, A. S.; Orlova, A. G.; Maslennikova, A. V.; Brilkina, A. A.; Balalaeva, I. V.; Antonova, N. O.; Mishina, N. M.; Shakhova, N. M.; Belousov, V. V.

    2014-03-01

    The aim of the work was to study the participation of hydrogen peroxide in reaction of cervical cancer cell line HeLa Kyoto on cisplatin action. Determination of hydrogen peroxide level was performed using genetically encoded fluorescent sensor HyPer2. The dependence of cell viability on cisplatin concentration was determined using MTT assay. Mechanisms of cell death as well as HyPer2 reaction was revealed by flow cytometry after 6-hours of incubation with cisplatin in different concentrations. Cisplatin used in low concentrations had no effect on hydrogen peroxide level in HeLa Kyoto cells. Increase of HyPer2 fluorescence was detected only after exposure with cisplatin in high concentration. The reaction was not the consequence of cell death.

  20. Ethical Issues in Using Children's Blood Lead Levels as a Remedial Action Objective

    PubMed Central

    Evans, Emily Lorraine

    2011-01-01

    The Environmental Protection Agency measures the success or failure of Superfund site remediation efforts against remedial action objectives (RAOs). RAOs are frequently based on environmental contaminant concentrations, but with lead exposure, blood lead levels from the population at risk are often used. Although childhood lead screening is an important public health tool, an RAO based on child blood lead levels raises ethical concerns: public health efforts that are more reactive than preventive, a blood lead standard (10 μg/dL) that may not be fully protective, the use of a measure whose validity and reliability may be easily compromised, and exacerbation of environmental injustice and systematic disadvantages. The example of Bunker Hill mine, Kellogg, Idaho, allowed an examination of these ethical concerns. PMID:21836120

  1. Corrective Action Decision Document/Closure Report for Corrective Action Unit 375: Area 30 Buggy Unit Craters, Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews

    2011-08-01

    Corrective Action Unit 375 comprises three corrective action sites (CASs): (1) 25-23-22, Contaminated Soils Site; (2) 25-34-06, Test Cell A Bunker; and (3) 30-45-01, U-30a, b, c, d, e Craters. The purpose of this CADD/CR is to provide justification and documentation supporting the recommendation that no further corrective action is needed for CAU 375 based on the implementation of corrective action of closure in place with administrative controls at CAS 25-23-22, no further action at CAS 25-34-06, and closure in place with administrative controls and removal of potential source material (PSM) at CAS 30-45-01. Corrective action investigation (CAI) activities were performed from July 28, 2010, through April 4, 2011, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 375: Area 30 Buggy Unit Craters. The approach for the CAI was divided into two facets: investigation of the primary release of radionuclides, and investigation of other releases (migration in washes and chemical releases). The purpose of the CAI was to fulfill data needs as defined during the data quality objective (DQO) process. The CAU 375 dataset of investigation results was evaluated based on the data quality assessment. This assessment demonstrated the dataset is acceptable for use in fulfilling the DQO data needs. Investigation results were evaluated against final action levels (FALs) established in this document. A radiological dose FAL of 25 millirem per year was established based on the Remote Work Area exposure scenario (336 hours of annual exposure). Radiological doses exceeding the FAL were assumed to be present within the default contamination boundaries at CASs 25-23-22 and 30-45-01. No contaminants were identified at CAS 25-34-06, and no corrective action is necessary. Potential source material in the form of lead plate, lead-acid batteries, and oil within an abandoned transformer were identified at CAS 30-45-01, and corrective actions were undertaken that

  2. The Dilemma of High Level Planning in Distributed Agile Software Projects: An Action Research Study in a Danish Bank

    NASA Astrophysics Data System (ADS)

    Svejvig, Per; Fladkjær Nielsen, Ann-Dorte

    The chapter reports on an action research study with the aim to design a high level planning process in distributed and co-located software projects based on agile methods. The main contributions are the insight that high level planning process is highly integrated with other project disciplines and specific steps has to be taken to apply the process in distributed projects; and the action research approach is indeed suitable to software process improvements.

  3. Pharmacologic manipulation of the flushing action of cerebrospinal fluid. Effect on CSF diatrizoate levels.

    PubMed

    Harnish, P P; Samuel, K

    1988-12-01

    The continual production and absorption of cerebrospinal fluid (CSF) provides for the dilution and removal of potentially toxic substances from the central nervous system (CNS). This study quantified changes in the CSF concentration of diatrizoate following pretreatment with various drugs that alter CSF production. Adult rats, pretreated with one of ten drugs or normal saline (control) and anesthetized, received sodium diatrizoate (2 mL/kg, IV). Blood and CSF were sampled 2 hours later, and the diatrizoate concentrations were measured. Serum diatrizoate levels in the control group averaged 144.3 micrograms/mL. There were no significant differences in serum levels between control and pretreated groups. The CSF diatrizoate concentration in the control group averaged 10.8 micrograms/mL. Pretreatment with acetazolamide, ritodrine, or probenecid resulted in a significant increase in the CSF concentration, to 24.7 micrograms/mL or 228% of control in the case of acetazolamide. Pretreatment with salicylate, carbachol, or aminophylline resulted in significantly lower CSF diatrizoate levels than control; 3.2 micrograms/mL (30% of control) for carbachol. Digoxin, furosemide, dibutyryl cAMP, or dexamethasone pretreatments had no significant effect on CSF diatrizoate concentrations. Thus, a wide range of drugs may significantly alter the concentration of diatrizoate in the CNS. Drug-induced changes in the rate of CSF production may be responsible for this action. PMID:2849595

  4. Corrective Action Plan for INEL low-level waste management ES&H vulnerabilities

    SciTech Connect

    1996-07-01

    Low-level waste (LLW) activities at INEL include numerous waste generators, storage facilities, three treatment facilities, and one disposal facility. The Working Group Assessment Team (WGAT) conducted an assessment of the LLW management program in response to the Defense Nuclear Facilities Safety Board (DNFSB) Recommendation 94-2 (Conformance with Safety Standards at Department of Energy Low-Level Nuclear Waste and Disposal Facilities). Assessment included review of waste generators, liquid effluent treatment, storage facilities and practices, and a disposal facility with vaults and a shallow subsurface burial site. WGAT reviewed relevant documents and conducted tours concerning these LLW operations. The vulnerabilities identified by WGAT were similar to those self-identified by INEL (storage and disposal of LLW). This assessment resulted in the documentation of 8 vulnerabilities and 3 conditions. WGAT assessed the overall LLW/mixed low-level waste (MLLW) management program at INEL as being generally effective. As recommended by DNFSB, a site-specific Corrective Action Plan has been prepared and constitutes the initial site improvement activities.

  5. Corrective Action Investigation Plan for Corrective Action Unit 366: Area 11 Plutonium Valley Dispersion Sites, Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews

    2011-09-01

    Corrective Action Unit 366 comprises the six corrective action sites (CASs) listed below: (1) 11-08-01, Contaminated Waste Dump No.1; (2) 11-08-02, Contaminated Waste Dump No.2; (3) 11-23-01, Radioactively Contaminated Area A; (4) 11-23-02, Radioactively Contaminated Area B; (5) 11-23-03, Radioactively Contaminated Area C; and (6) 11-23-04, Radioactively Contaminated Area D. These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of CAAs that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed July 6, 2011, by representatives of the Nevada Division of Environmental Protection and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 366. The presence and nature of contamination at CAU 366 will be evaluated based on information collected from a field investigation. Radiological contamination will be evaluated based on a comparison of the total effective dose (TED) at sample locations to the dose-based final action level (FAL). The TED will be calculated by summing the estimates of internal and external dose. Results from the analysis of soil samples collected from sample plots will be used to calculate internal radiological dose. Thermoluminescent dosimeters placed at each sample location will be used to measure external radiological dose. Based on historical documentation of the releases

  6. Institutional Diversity in Collective Action: Investigating Successful Village Level Maintenance of Hand Pumps in Malawi

    NASA Astrophysics Data System (ADS)

    Joubert, Brian Anthony

    Providing clean water to rural communities in sub-Saharan Africa remains a challenge. Unsanitary and distant water sources cause a host of health and humanitarian problems. A common means of remedying this situation has been the donation of improved water sources, fitted with low-cost hand pumps. Due donor capacity and/ or policy most hand pumps are donated under the guise of Village Level Operation and Maintenance (VLOM). This premises the notion that recipient communities will take ownership of the new pump and as such will ensure its maintenance. To assist with this many donors carry out programs of technical repair training and the structuring of in-village leadership and management groups. The reality is that a high proportion of these pumps break down after donation and cease to work thereafter. Measures to redress technical elements of these failures through increased training or adequate distribution of spares has seen some success but failure rates remains high. This has led to a call for more attention to demand side issues, focusing on the communal aspects that may influence a village to act collectively in the maintenance of its hand pump. This thesis researched five Malawian villages where the community had maintained their hand pumps for a period of 10 or more years. These hand pumps were treated as shared resources and the literature on common-pool resources and social institutions was used as a theoretical framework. Applying these theories proved to be appropriate for analyzing the norms, conventions and forms of cooperative conduct. This allowed the research to gain insights into institutional diversity and the relationship between 'formal institutions', most often exogenous in nature, and informal' or customary collective action institutions embedded within the communities. Findings showed the emergence of three predominant themes within these successful case studies: 1) the role of leadership at varying levels and how it is embodied

  7. Consideration of measurement error when using commercial indoor radon determinations for selecting radon action levels

    USGS Publications Warehouse

    Reimer, G.M.; Szarzi, S.L.; Dolan, Michael P.

    1998-01-01

    An examination of year-long, in-home radon measurement in Colorado from commercial companies applying typical methods indicates that considerable variation in precision exists. This variation can have a substantial impact on any mitigation decisions, either voluntary or mandated by law, especially regarding property sale or exchange. Both long-term exposure (nuclear track greater than 90 days), and short-term (charcoal adsorption 4-7 days) exposure methods were used. In addition, periods of continuous monitoring with a highly calibrated alpha-scintillometer took place for accuracy calibration. The results of duplicate commercial analysis show that typical results are no better than ??25 percent with occasional outliers (up to 5 percent of all analyses) well beyond that limit. Differential seasonal measurements (winter/summer) by short-term methods provide equivalent information to single long-term measurements. Action levels in the U.S. for possible mitigation decisions should be selected so that they consider the measurement variability; specifically, they should reflect a concentration range similar to that adopted by the European Community.

  8. Corrective Action Investigation Plan for Corrective Action Unit 104: Area 7 Yucca Flat Atmospheric Test Sites, Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews

    2011-08-01

    of the total effective dose (TED) to the dose-based final action level (FAL). The presence of TED exceeding the FAL is considered a radiological contaminant of concern (COC). Anything identified as a COC will require corrective action. The TED will be calculated as the total of separate estimates of internal and external dose. Results from the analysis of soil samples will be used to calculate internal radiological dose. Thermoluminescent dosimeters will be used to measure external radiological dose. Based on process knowledge of the releases associated with the nuclear tests and radiological survey information about the location and shape of the resulting contamination plume, it was determined that the releases from the nuclear tests are co-located and will be investigated concurrently. A field investigation will be performed to define areas where TED exceeds the FAL and to determine whether other COCs are present at the site. The investigation will also collect information to determine the presence and nature of contamination associated with migration and excavation, as well as any potential releases discovered during the investigation. Appendix A provides a detailed discussion of the DQO methodology and the DQOs specific to each CAS.

  9. 78 FR 56719 - Draft Guidance for Industry on Arsenic in Apple Juice: Action Level; Supporting Document for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-13

    ... protective of human health and achievable with the use of good manufacturing practices. It also describes FDA...: Action Level'' that appeared in the Federal Register of July 15, 2013 (78 FR 42086). The draft guidance...-1639. SUPPLEMENTARY INFORMATION: I. Background In the Federal Register of July 15, 2013 (78 FR...

  10. Addendum to the Closure Report for Corrective Action Unit 214: Bunkers and Storage Areas Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Lynn Kidman

    2008-10-01

    This document constitutes an addendum to the September 2006, Closure Report for Corrective Action Unit 214: Bunkers and Storage Areas as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the URs for: • CAS 25-23-01, Contaminated Materials • CAS 25-23-19, Radioactive Material Storage These URs were established as part of Federal Facility Agreement and Consent Order (FFACO) corrective actions and were based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since these URs were established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, these URs were re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the URs) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove

  11. Addendum to the Closure Report for Corrective Action Unit 403: Second Gas Station, Tonopah Test Range, Nevada, Revision 0

    SciTech Connect

    Grant Evenson

    2009-05-01

    This document constitutes an addendum to the Closure Report for Corrective Action Unit 403: Second Gas Station, Tonopah Test Range, Nevada, September 1998 as described in the document Supplemental Investigation Report for FFACO Use Restrictions, Nevada Test Site, Nevada (SIR) dated November 2008. The SIR document was approved by NDEP on December 5, 2008. The approval of the SIR document constituted approval of each of the recommended UR removals. In conformance with the SIR document, this addendum consists of: • This page that refers the reader to the SIR document for additional information • The cover, title, and signature pages of the SIR document • The NDEP approval letter • The corresponding section of the SIR document This addendum provides the documentation justifying the cancellation of the UR for CAS 03-02-004-0360, Underground Storage Tanks. This UR was established as part of a Federal Facility Agreement and Consent Order (FFACO) corrective action and is based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996). Since this UR was established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, this UR was reevaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006). This re-evaluation consisted of comparing the original data (used to define the need for the UR) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove the UR because contamination is not present at the site above the risk-based FALs. Requirements for inspecting and maintaining this UR will be canceled, and the postings and signage at this site will be removed. Fencing and posting may be present at this site that are unrelated to the FFACO UR

  12. Addendum to the Closure Report for Corrective Action Unit 398: Area 25 Spill Sites, Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Lynn Kidman

    2008-10-01

    This document constitutes an addendum to the April 2003, Closure Report for Corrective Action Unit 398: Area 25 Spill Sites as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the UR for CAS 25-25-17, Subsurface Hydraulic Oil Spill. This UR was established as part of a Federal Facility Agreement and Consent Order (FFACO) corrective action and is based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since this UR was established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, this UR was re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the UR) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove the UR because contamination is not present at the site above

  13. Mapping heatwave health risk at the community level for public health action

    PubMed Central

    2012-01-01

    Background Climate change poses unprecedented challenges, ranging from global and local policy challenges to personal and social action. Heat-related deaths are largely preventable, but interventions for the most vulnerable populations need improvement. Therefore, the prior identification of high risk areas at the community level is required to better inform planning and prevention. We aimed to demonstrate a simple and flexible conceptual framework relying upon satellite thermal data and other digital data with the goal of easily reproducing this framework in a variety of urban configurations. Results The study area encompasses Rennes, a medium-sized French city. A Landsat ETM + image (60 m resolution) acquired during a localized heatwave (June 2001) was used to estimate land surface temperature (LST) and derive a hazard index. A land-use regression model was performed to predict the LST. Vulnerability was assessed through census data describing four dimensions (socio-economic status, extreme age, population density and building obsolescence). Then, hazard and vulnerability indices were combined to deliver a heatwave health risk index. The LST patterns were quite heterogeneous, reflecting the land cover mosaic inside the city boundary, with hotspots of elevated temperature mainly observed in the city center. A spatial error regression model was highly predictive of the spatial variation in the LST (R2 = 0.87) and was parsimonious. Three land cover descriptors (NDVI, vegetation and water fractions) were negatively linked with the LST. A sensitivity analysis (based on an image acquired on July 2000) yielded similar results. Southern areas exhibited the most vulnerability, although some pockets of higher vulnerability were observed northeast and west of the city. The heatwave health risk map showed evidence of infra-city spatial clustering, with the highest risks observed in a north–south central band. Another sensitivity analysis gave a very high

  14. Levels and actions of neuroactive steroids in the nervous system under physiological and pathological conditions: Sex-specific features.

    PubMed

    Melcangi, Roberto C; Giatti, Silvia; Garcia-Segura, Luis M

    2016-08-01

    Neuroactive steroids regulate the physiology of the central and peripheral nervous system, exert neuroprotective actions and represent interesting tools for therapeutic strategies against neurodegenerative and psychiatric disorders. Sex differences in their levels are detected not only under physiological conditions but are also modified in a sex-dependent way in different pathological alterations such as Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, traumatic brain injury, spinal cord injury, stroke, diabetic encephalopathy, psychiatric disorders and peripheral neuropathy. Interestingly, many of these disorders show sex differences in their incidence, symptomatology and/or neurodegenerative outcome. The neuroprotective actions of neuroactive steroids, together with the sex specific regulation of its levels might provide the basis to design sex-specific neuroprotective therapies. Indeed, some experiments here discussed suggest the viability of this approach. PMID:26657814

  15. An fMRI study of joint action-varying levels of cooperation correlates with activity in control networks.

    PubMed

    Chaminade, Thierry; Marchant, Jennifer L; Kilner, James; Frith, Christopher D

    2012-01-01

    As social agents, humans continually interact with the people around them. Here, motor cooperation was investigated using a paradigm in which pairs of participants, one being scanned with fMRI, jointly controlled a visually presented object with joystick movements. The object oscillated dynamically along two dimensions, color and width of gratings, corresponding to the two cardinal directions of joystick movements. While the overall control of each participant on the object was kept constant, the amount of cooperation along the two dimensions varied along four levels, from no (each participant controlled one dimension exclusively) to full (each participant controlled half of each dimension) cooperation. Increasing cooperation correlated with BOLD signal in the left parietal operculum and anterior cingulate cortex (ACC), while decreasing cooperation correlated with activity in the right inferior frontal and superior temporal gyri, the intraparietal sulci and inferior temporal gyri bilaterally, and the dorsomedial prefrontal cortex. As joint performance improved with the level of cooperation, we assessed the brain responses correlating with behavior, and found that activity in most of the areas associated with levels of cooperation also correlated with the joint performance. The only brain area found exclusively in the negative correlation with cooperation was in the dorso medial frontal cortex, involved in monitoring action outcome. Given the cluster location and condition-related signal change, we propose that this region monitored actions to extract the level of cooperation in order to optimize the joint response. Our results, therefore, indicate that, in the current experimental paradigm involving joint control of a visually presented object with joystick movements, the level of cooperation affected brain networks involved in action control, but not mentalizing. PMID:22715326

  16. Corrective Action Investigation Plan for Corrective Action Unit 367: Area 10 Sedan, Ess and Uncle Unit Craters Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews

    2009-12-01

    Corrective Action Unit 367 is located in Area 10 of the Nevada Test Site, which is approximately 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 367 comprises the four corrective action sites (CASs) listed below: • 10-45-01, U-10h Crater (Sedan) • 10-45-02, Ess Crater Site • 10-09-03, Mud Pit • 10-45-03, Uncle Crater Site The CASs in CAU 367 are being investigated because hazardous and/or radioactive contaminants may be present in concentrations that exceed risk-based corrective action (RBCA) levels. Existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend CAAs for the CASs. Additional information will be generated by conducting a CAI before evaluating and selecting CAAs. The scope of the corrective action investigation for CAU 367 includes the following activities: • Move surface debris and/or materials, as needed, to facilitate sampling. • Conduct radiological surveys. • Collect and submit environmental samples for laboratory analysis to determine the area where TED at the site exceeds FALs (i.e., corrective action boundary). • Evaluate TED to potential receptors in areas along Mercury Highway that have been impacted by a release of radionuclides from the Sedan test. • Collect and submit environmental samples for laboratory analysis related to the drilling mud within CAS 10-09-03, Mud Pit, and any encountered stains or waste as necessary to determine whether COCs are present. • If COCs are present, collect additional step-out samples to define the extent of the contamination. • Collect samples of investigation-derived waste, as needed, for waste management purposes.

  17. Synapse-Level Determination of Action Potential Duration by K(+) Channel Clustering in Axons.

    PubMed

    Rowan, Matthew J M; DelCanto, Gina; Yu, Jianqing J; Kamasawa, Naomi; Christie, Jason M

    2016-07-20

    In axons, an action potential (AP) is thought to be broadcast as an unwavering binary pulse over its arbor, driving neurotransmission uniformly at release sites. Yet by recording from axons of cerebellar stellate cell (SC) interneurons, we show that AP width varies between presynaptic bouton sites, even within the same axon branch. The varicose geometry of SC boutons alone does not impose differences in spike duration. Rather, axonal patching revealed heterogeneous peak conductance densities of currents mediated mainly by fast-activating Kv3-type potassium channels, with clustered hotspots at boutons and restricted expression at adjoining shafts. Blockade of Kv channels at individual boutons indicates that currents immediately local to a release site direct spike repolarization at that location. Thus, the clustered arrangement and variable expression density of Kv3 channels at boutons are key determinants underlying compartmentalized control of AP width in a near synapse-by-synapse manner, multiplying the signaling capacity of these structures. PMID:27346528

  18. Addendum to the Closure Report for Corrective Action Unit 342: Area 23 Mercury Fire Training Pit Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Lynn Kidman

    2008-10-01

    This document constitutes an addendum to the April 2000, Closure Report for Corrective Action Unit 342: Area 23 Mercury Fire Training Pit as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the UR for CAS 23-56-01, Former Mercury Fire Training Pit. This UR was established as part of a Federal Facility Agreement and Consent Order (FFACO) corrective action and is based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since this UR was established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, this UR was re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the UR) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove the UR because contamination is not present at

  19. Addendum to the Closure Report for Corrective Action Unit 322: Areas 1 & 3 Release Sites and Injection Wells Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Lynn Kidman

    2008-10-01

    This document constitutes an addendum to the June 2006, Closure Report for Corrective Action Unit 322: Areas 1 & 3 Release Sites and Injection Wells as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the URs for: • CAS 01-25-01, AST Release • CAS 03-25-03, Mud Plant AST Diesel Release These URs were established as part of Federal Facility Agreement and Consent Order (FFACO) corrective actions and were based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since these URs were established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, these URs were re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the URs) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to

  20. Addendum to the Closure Report for Corrective Action Unit 356: Mud Pits and Disposal Sites Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Lynn Kidman

    2008-10-01

    This document constitutes an addendum to the November 2002, Closure Report for Corrective Action Unit 356: Mud Pits and Disposal Sites as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the URs for: • CAS 03-04-01, Area 3 Change House Septic System • CAS 03-09-04, Mud Pit These URs were established as part of Federal Facility Agreement and Consent Order (FFACO) corrective actions and were based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since these URs were established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, these URs were re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the URs) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove these

  1. Addendum to the Closure Report for Corrective Action Unit 427: Area 3 Septic Waste Systems 2, 6, Tonopah Test Range, Nevada, Revision 0

    SciTech Connect

    Lynn Kidman

    2008-10-01

    This document constitutes an addendum to the April 1999, Closure Report for Corrective Action Unit 427: Area 3 Septic Waste Systems 2, 6, Tonopah Test Range, Nevada as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the URs for: • CAS 03-05-002-SW02, Septic Waste System • CAS 03-05-002-SW06, Septic Waste System These URs were established as part of Federal Facility Agreement and Consent Order (FFACO) corrective actions and were based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since these URs were established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, these URs were re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the URs) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re

  2. Addendum to the Closure Report for Corrective Action Unit 358: Areas 18, 19, 20 Cellars/Mud Pits Nevada Test Site, Nevada

    SciTech Connect

    Lynn Kidman

    2008-10-01

    This document constitutes an addendum to the January 2004, Closure Report for Corrective Action Unit 358: Areas 18, 19, 20 Cellars/Mud Pits as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the URs for: • CAS 20-23-02, Postshot Cellar • CAS 20-23-03, Cellar • CAS 20-23-04, Postshot Cellar • CAS 20-23-05, Postshot Cellar • CAS 20-23-06, Cellar • CAS 20-37-01, Cellar & Mud Pit • CAS 20-37-05, Cellar These URs were established as part of Federal Facility Agreement and Consent Order (FFACO) corrective actions and were based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since these URs were established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, these URs were re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the URs) to risk-based final action

  3. Addendum to the Closure Report for Corrective Action Unit 335: Area 6 Injection Well and Drain Pit Nevada Test Site, Nevada, Revison 0

    SciTech Connect

    Lynn Kidman

    2008-10-01

    This document constitutes an addendum to the June 2003, Closure Report for Corrective Action Unit 335: Area 6 Injection Well and Drain Pit as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the URs for: • CAS 06-20-02, 20-inch Cased Hole • CAS 06-23-03, Drain Pit These URs were established as part of Federal Facility Agreement and Consent Order (FFACO) corrective actions and were based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since these URs were established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, these URs were re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the URs) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove these URs because

  4. Addendum to the Closure Report for Corrective Action Unit 326: Areas 6 and 27 Release Sites, Nevada Test Site, Nevada, Revision 1

    SciTech Connect

    Grant Evenson

    2009-05-01

    This document constitutes an addendum to the Closure Report for Corrective Action Unit 326: Areas 6 and 27 Release Sites, Nevada Test Site, Nevada (Revision 1), December 2002 as described in the document Supplemental Investigation Report for FFACO Use Restrictions, Nevada Test Site, Nevada (SIR) dated November 2008. The SIR document was approved by NDEP on December 5, 2008. The approval of the SIR document constituted approval of each of the recommended UR removals. In conformance with the SIR document, this addendum consists of: • This page that refers the reader to the SIR document for additional information • The cover, title, and signature pages of the SIR document • The NDEP approval letter • The corresponding section of the SIR document This addendum provides the documentation justifying the cancellation of the UR for CAS 06-25-01, CP-1 Heating Oil Release. This UR was established as part of a Federal Facility Agreement and Consent Order (FFACO) corrective action and is based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996). Since this UR was established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, this UR was reevaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006). This re-evaluation consisted of comparing the original data (used to define the need for the UR) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove the UR because contamination is not present at the site above the risk-based FALs. Requirements for inspecting and maintaining this UR will be canceled, and the postings and signage at this site will be removed. Fencing and posting may be present at this site that are unrelated to

  5. Addendum to the Streamlined Approach for Environmental Restoration Closure Report for Corrective Action Unit 454: Historical Undrground Storage Tank Release Sites, Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Lynn Kidman

    2008-10-01

    This document constitutes an addendum to the April 1998, Streamlined Approach for Environmental Restoration Closure Report for Corrective Action Unit 454: Historical Underground Storage Tank Release Sites as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the UR for CAS 12-25-09, Spill 960722-02 (from UST 12-B-3). This UR was established as part of a Federal Facility Agreement and Consent Order (FFACO) corrective action and is based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since this UR was established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, this UR was re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the UR) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a

  6. Addendum to the Closure Report for Corrective Action Unit 423: Area 3 Building 03-60 Underground Discharge Point, Tonopah Test Range, Nevada, Revision 0

    SciTech Connect

    Lynn Kidman

    2008-10-01

    This document constitutes an addendum to the July 1999, Closure Report for Corrective Action Unit 423: Area 3 Building 0360 Underground Discharge Point, Tonopah Test Range, Nevada as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the UR for CAS 03-02-002-0308, Underground Discharge Point. This UR was established as part of a Federal Facility Agreement and Consent Order (FFACO) corrective action and is based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since this UR was established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, this UR was re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the UR) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove the

  7. Addendum to the Streamlined Approach for Environmental Restoration Closure Report for Corrective Action Unit 452: Historical Underground Storage Tank Release Sites, Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Grant Evenson

    2009-05-01

    This document constitutes an addendum to the Streamlined Approach for Environmental Restoration Closure Report for Corrective Action Unit 452: Historical Underground Storage Tank Release Sites, Nevada Test Site, Nevada, April 1998 as described in the document Supplemental Investigation Report for FFACO Use Restrictions, Nevada Test Site, Nevada (SIR) dated November 2008. The SIR document was approved by NDEP on December 5, 2008. The approval of the SIR document constituted approval of each of the recommended UR removals. In conformance with the SIR document, this addendum consists of: • This page that refers the reader to the SIR document for additional information • The cover, title, and signature pages of the SIR document • The NDEP approval letter • The corresponding section of the SIR document This addendum provides the documentation justifying the cancellation of the URs for CASs: • 25-25-09, Spill H940825C (from UST 25-3101-1) • 25-25-14, Spill H940314E (from UST 25-3102-3) • 25-25-15, Spill H941020E (from UST 25-3152-1) These URs were established as part of Federal Facility Agreement and Consent Order (FFACO) corrective actions and were based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996). Since these URs were established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, these URs were re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006). This re-evaluation consisted of comparing the original data (used to define the need for the URs) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove these URs because contamination is not present at these sites above the risk-based FALs

  8. Addendum to the Closure Report for Corrective Action Unit 394: Areas 12, 18, and 29 Spill/Release Sites Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Lynn Kidman

    2008-10-01

    This document constitutes an addendum to the September 2003, Closure Report for Corrective Action Unit 394: Areas 12, 18, and 29 Spill/Release Sites as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the URs for: • CAS 12-25-04, UST 12-16-2 Waste Oil Release • CAS 18-25-01, Oil Spills • CAS 18-25-02, Oil Spills • CAS 18-25-03, Oil Spill • CAS 29-44-01, Fuel Spill These URs were established as part of Federal Facility Agreement and Consent Order (FFACO) corrective actions and were based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since these URs were established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, these URs were re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the URs) to risk-based final action levels (FALs) developed using the

  9. Addendum 2 to the Closure Report for Corrective Action Unit 358: Areas 18, 19, 20 Cellars/Mud Pits, Nevada Test Site, Nevada, Revison 0

    SciTech Connect

    Grant Evenson

    2009-05-01

    This document constitutes an addendum to the Closure Report for Corrective Action Unit 358: Areas 18, 19, 20 Cellars/Mud Pits, Nevada Test Site, Nevada, January 2004 as described in the document Supplemental Investigation Report for FFACO Use Restrictions, Nevada Test Site, Nevada (SIR) dated November 2008. The SIR document was approved by NDEP on December 5, 2008. The approval of the SIR document constituted approval of each of the recommended UR removals. In conformance with the SIR document, this addendum consists of: • This page that refers the reader to the SIR document for additional information • The cover, title, and signature pages of the SIR document • The NDEP approval letter • The corresponding section of the SIR document This addendum provides the documentation justifying the cancellation of the UR for CAS 19-09-05, Mud Pit. This UR was established as part of a Federal Facility Agreement and Consent Order (FFACO) corrective action and is based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996). Since this UR was established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, this UR was reevaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006). This re-evaluation consisted of comparing the original data (used to define the need for the UR) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove the UR because contamination is not present at the site above the risk-based FALs. Requirements for inspecting and maintaining this UR will be canceled, and the postings and signage at this site will be removed. Fencing and posting may be present at this site that are unrelated to the FFACO UR such as for

  10. Addendum 2 to the Streamlined Approach for Environmental Restoration Closure Report for Corrective Action Unit 454: Historical Underground Storage Tank Release Sites, Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Grant Evenson

    2009-05-01

    This document constitutes an addendum to the Streamlined Approach for Environmental Restoration Closure Report for Corrective Action Unit 454: Historical Underground Storage Tank Release Sites, Nevada Test Site, Nevada, April 1998 as described in the document Supplemental Investigation Report for FFACO Use Restrictions, Nevada Test Site, Nevada (SIR) dated November 2008. The SIR document was approved by NDEP on December 5, 2008. The approval of the SIR document constituted approval of each of the recommended UR removals. In conformance with the SIR document, this addendum consists of: • This page that refers the reader to the SIR document for additional information • The cover, title, and signature pages of the SIR document • The NDEP approval letter • The corresponding section of the SIR document This addendum provides the documentation justifying the cancellation of the URs for CASs: • 12-25-08, Spill H950524F (from UST 12-B-1) • 12-25-10, Spill H950919A (from UST 12-COMM-1) These URs were established as part of Federal Facility Agreement and Consent Order (FFACO) corrective actions and were based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996). Since these URs were established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, these URs were re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006). This re-evaluation consisted of comparing the original data (used to define the need for the URs) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove these URs because contamination is not present at these sites above the risk-based FALs. Requirements for inspecting and maintaining these URs will be

  11. Corrective Action Decision Document/ Closure Report for Corrective Action Unit 556: Dry Wells and Surface Release Points, Nevada Test Site, Nevada with Errata Sheet, Revision 0

    SciTech Connect

    Grant Evenson

    2008-09-01

    This Corrective Action Decision Document (CADD)/Closure Report (CR) has been prepared for Corrective Action Unit 556, Dry Wells and Surface Release Points, located at the Nevada Test Site, Nevada, in accordance with the Federal Facility Agreement and Consent Order (FFACO, 1996; as amended February 2008). Corrective Action Unit (CAU) 556 is comprised of four corrective action sites (CASs): • 06-20-04, National Cementers Dry Well • 06-99-09, Birdwell Test Hole • 25-60-03, E-MAD Stormwater Discharge and Piping • 25-64-01, Vehicle Washdown and Drainage Pit The purpose of this CADD/CR is to provide justification and documentation supporting the recommendation for closure of CAU 556 with no further corrective action. To achieve this, corrective action investigation (CAI) activities began on February 7 and were completed on June 19, 2008, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 556: Dry Wells and Surface Release Points, Nevada Test Site, Nevada (NNSA/NSO, 2007). The purpose of the CAI was to fulfill the following data needs as defined during the data quality objective (DQO) process: • Determine whether contaminants of concern (COCs) are present. • If COCs are present, determine their nature and extent. • Provide sufficient information and data to complete appropriate corrective actions. The CAU 556 data were evaluated based on the data quality assessment process, which demonstrated the quality and acceptability of the data for use in fulfilling the DQO data needs. Analytes detected during the CAI were evaluated against appropriate final action levels (FALs) to identify the COCs for each CAS. The results of the CAI identified COCs at one of the four CASs in CAU 556 that required the completion of a corrective action. Assessment of the data generated from investigation activities conducted at CAU 556 revealed the following: • Corrective Action Sites 06-20-04, 06-99-09, and 25-64-01 do not contain contamination at

  12. Kinemage of action - Proposed reaction mechanism of glutamate-1-semialdehyde aminomutase at an atomic level

    SciTech Connect

    Sorensen, John L.; Stetefeld, Joerg

    2011-10-07

    Highlights: {yields} Inhibitors of tetrapyrrole cofactor biosynthesis may be useful antibiotics. {yields} Mechanism of critical enzyme, glutamate-1-semialdehyde aminomutase, is presented. {yields} Unique vitamin B6-dependant enzyme traps intermediate in active site. {yields} Molecular dynamics show that a re-orientation of the substrate is required. -- Abstract: Glutamate-1-semialdehyde aminomutase (GSAM), a key enzyme in tetrapyrrole cofactor biosynthesis, performs a unique transamination on a single substrate. The substrate, glutamate-1-semialdehyde (GSA), undergoes a reaction that exchanges the position of an amine and a carbonyl group to produce 5-aminolevulinic acid (ALA). This transamination reaction is unique in the fact that is does not require an external cofactor to act as a nitrogen donor or acceptor in this transamination reaction. One of the other remarkable features of the catalytic mechanism is the release free in the enzyme active site of the intermediate 4,5-diaminovaleric acid (DAVA). The action of a gating loop prevents the escape of DAVA from the active site. In a MD simulation approach, using snapshots provided by X-ray crystallography and protein crystal absorption spectrometry data, the individual catalytic steps in this unique intramolecular transamination have been elucidated.

  13. Addendum to the Closure Report for Corrective Action Unit 404: Roller Coaster Lagoons and Trench, Tonopah Test Range, Nevada, Revision 0

    SciTech Connect

    Lynn Kidman

    2008-10-01

    This document constitutes an addendum to the September 1998, Closure Report for Corrective Action Unit 404: Roller Coaster Lagoons and Trench, Tonopah Test Range, Nevada as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the URs for: • CAS TA-03-001-TARC Roller Coaster Lagoons • CAS TA-21-001-TARC Roller Coaster N. Disposal Trench These URs were established as part of Federal Facility Agreement and Consent Order (FFACO) corrective actions and were based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since these URs were established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, these URs were re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the URs) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The

  14. Addendum to the Closure Report for Corrective Action Unit 404: Roller Coaster Sewage Lagoons and North Disposal Trench, Tonopah Test Range, Nevada, Revision 1

    SciTech Connect

    Lynn Kidman

    2009-02-01

    This document constitutes an addendum to the September 1998, Closure Report for Corrective Action Unit 404: Roller Coaster Lagoons and Trench, Tonopah Test Range, Nevada as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the modification of the UR for CAS TA-03-001-TARC Roller Coaster Lagoons. This UR was established as part of Federal Facility Agreement and Consent Order (FFACO) corrective actions and was based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since this UR was established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, this UR was re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This reevaluation consisted of comparing the original data (used to define the need for the UR) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to modify the UR for CAS TA-03

  15. Addendum to the Closure Report for Corrective Action Unit 271: Areas 25, 26, and 27 Septic Systems Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Lynn Kidman

    2008-10-01

    This document constitutes an addendum to the August 2004, Closure Report for Corrective Action Unit 271, Areas 25, 26, and 27 Septic Systems as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the modification of the UR for CAS 27-05-02, Leachfield. This UR was established as part of a Federal Facility Agreement and Consent Order (FFACO) corrective action and is based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since this UR was established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, this UR was re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the UR) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to modify the UR to an administrative UR. Administrative URs differ from

  16. Systemic High School Reform in Two States: The Serendipity of State-Level Action

    ERIC Educational Resources Information Center

    Hamann, Edmund T.

    2005-01-01

    Maine and Vermont have been national leaders in state-level coordination of high school reform. Both recently developed almost interchangeable, new, voluntary, statewide frameworks that describe multiple ways high schools should change. Both frameworks--Promising Futures (Maine Commission on Secondary Education 1998) and High Schools on the Move…

  17. Following Alice: Theories of Critical Thinking and Reflective Practice in Action at Postgraduate Level

    ERIC Educational Resources Information Center

    Swanwick, Ruth; Kitchen, Ruth; Jarvis, Joy; McCracken, Wendy; O'Neil, Rachel; Powers, Steve

    2014-01-01

    This paper presents a flexible framework of principles for teaching critical thinking and reflective practice skills at the postgraduate level. It reports on a collaborative project between four UK institutions providing postgraduate programmes in deaf education. Through a critical review of current theories of critical thinking and reflective…

  18. Top-level players' visual control of interceptive actions: Bootsma and van Wieringen (1990) 20 years later.

    PubMed

    Bootsma, Reinoud J; Fernandez, Laure; Morice, Antoine H P; Montagne, Gilles

    2010-08-01

    Using a two-step approach, Van Soest et al. (2010) recently questioned the pertinence of the conclusions drawn by Bootsma and Van Wieringen (1990) with respect to the visual regulation of an exemplary rapid interceptive action: the attacking forehand drive in table tennis. In the first step, they experimentally compared the movement behaviors of their participants under conditions with and without vision available during the execution of the drive. In the second step, through simulation they evaluated the extent to which a preprogrammed pattern of muscle stimulation acting on the dynamical characteristics of the musculoskeletal system could explain the patterns of movement observed, including the phenomena of kinematic convergence and compensatory variability. In this contribution, we show how methodological and conceptual shortcomings, pertaining to both parts of Van Soest et al.'s study, severely limit the impact of their findings. We argue that their conclusion-denying the possibility of visual regulation of rapid interceptive actions-cannot be upheld in the light of the existing evidence, while Bootsma and Van Wieringen's conclusion-in favor of the visual regulation of rapid interceptive actions in top-level players- still holds strong, even after 20 years. Irrespective of the trends of the moment, we suggest that both appropriate experimentation and principled theorization need to be deployed before a model-based predictive architecture can be considered as a serious alternative to a (more parsimonious) information-based control architecture. PMID:20695718

  19. Examining movement variability in the basketball free-throw action at different skill levels.

    PubMed

    Button, Chris; MacLeod, Morven; Sanders, Ross; Coleman, Simon

    2003-09-01

    The analysis of variability both within and between performers can reveal important information about how athletes satisfy situational constraints. Transitory changes in the basketball free-throw shot were examined across different stages in skill development. Six female basketball players were selected, representing a range of playing expertise (pretest: 0-90% baskets scored). Each participant was video recorded performing 30 shots. Contrary to predictions, there was not a clear pattern of a reduction in trajectory variability with increasing skill level. However, improvements in skill level were associated with an increasing amount of intertrial movement consistency from the elbow and wrist joints. It is suggested that the angular motions of the elbow and wrist joints were compensated for each other toward the end of each throw to adapt to subtle changes in release parameters of the ball. PMID:14510290

  20. Addendum to the Closure Report for Corrective Action Unit 339: Area 12 Fleet Operations Steam Cleaning Discharge Area, Nevada Test Site, Revision 0

    SciTech Connect

    Grant Evenson

    2009-05-01

    This document constitutes an addendum to the Closure Report for CAU 339: Area 12 Fleet Operations Steam Cleaning Discharge Area Nevada Test Site, December 1997 as described in the document Supplemental Investigation Report for FFACO Use Restrictions, Nevada Test Site, Nevada (SIR) dated November 2008. The SIR document was approved by NDEP on December 5, 2008. The approval of the SIR document constituted approval of each of the recommended UR removals. In conformance with the SIR document, this addendum consists of: • This page that refers the reader to the SIR document for additional information • The cover, title, and signature pages of the SIR document • The NDEP approval letter • The corresponding section of the SIR document This addendum provides the documentation justifying the cancellation of the UR for CAS 12-19-01, A12 Fleet Ops Steam Cleaning Efflu. This UR was established as part of a Federal Facility Agreement and Consent Order (FFACO) corrective action and is based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996). Since this UR was established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, this UR was reevaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006). This re-evaluation consisted of comparing the original data (used to define the need for the UR) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove the UR because contamination is not present at the site above the risk-based FALs. Requirements for inspecting and maintaining this UR will be canceled, and the postings and signage at this site will be removed. Fencing and posting may be present at this site that are unrelated to the

  1. Coastal Hazards Maps: Actionable Information for Communities Facing Sea-Level Rise (Invited)

    NASA Astrophysics Data System (ADS)

    Gibeaut, J. C.; Barraza, E.

    2010-12-01

    Barrier islands along the U.S. Gulf coast remain under increasing pressure from development. This development and redevelopment is occurring despite recent hurricanes, ongoing erosion, and sea-level rise. To lessen the impacts of these hazards, local governments need information in a form that is useful for informing the public, making policy, and enforcing development rules. We recently completed the Galveston Island Geohazards Map for the city of Galveston, Texas and are currently developing maps for the Mustang and South Padre Island communities. The maps show areas that vary in their susceptibility to, and function for, mitigating the effects of geological processes, including sea-level rise, land subsidence, erosion and storm-surge flooding and washover. The current wetlands, beaches and dunes are mapped as having the highest geohazard potential both in terms of their exposure to hazardous conditions and their mitigating effects of those hazards for the rest of the island. These existing “critical environments” are generally protected under existing regulations. Importantly, however, the mapping recognizes that sea-level rise and shoreline retreat are changing the island; therefore, 60-year model projections of the effects of these changes are incorporated into the map. The areas that we project will become wetlands, beaches and dunes in the next 60 years are not protected. These areas are the most difficult to deal with from a policy point of view, yet we must address what happens there if real progress is to be made in how we live with sea-level rise. The geohazards maps draw on decades of geological knowledge of how barrier islands behave and put it in a form that is intuitive to the public and directly useful to planners. Some of the “messages” in the map include: leave salt marshes alone and give them room to migrate inland as sea level rises; set back and move development away from the shoreline to provide space for beaches and protective dunes

  2. The action of Clofazimine on the level of lysosomal enzymes of cultured macrophages.

    PubMed Central

    Sarracent, J; Finlay, C M

    1982-01-01

    Mouse peritoneal and calf alveolar macrophage cultures were exposed to various concentrations of Clofazimine, 3 (p-chloroanilino)-10-p-Chlorophenyl 2, 10-dihydro-2-isopropylimino, for 120 hr and an increase of four lysosomal enzymes were found with 0 . 3 micrograms/ml of the drug. In mouse peritoneal macrophage cultures, higher concentrations were toxic. Cycloheximide inhibited the lysosomal enzyme activity increase found. No change in enzymatic activity was observed when a lysosomal enriched granular fraction was incubated with various drug concentrations. Our results strongly suggest that Clofazimine at concentrations close to therapeutic serum levels induces de novo synthesis of lysosomal enzymes in macrophage cultures. PMID:7083642

  3. Permissive and Non-permissive Hypercapnia: Mechanisms of Action and Consequences of High Carbon Dioxide Levels

    PubMed Central

    Briva, Arturo; Lecuona, Emilia; Sznajder, Jacob I.

    2013-01-01

    Acute lung injury is a disease with high mortality, which affects a large numbers of patients whose treatment continues to be debated. It has recently been postulated that hypercapnia can attenuate the inflammatory response during lung injury, which would assign it a specific role within lung protection strategies during mechanical ventilation. In this paper, we review current evidence on the role that high levels of CO2 in the blood play in lung injury. We conclude that, although there are reports that show benefits, the most recent evidence suggests that hypercapnia can be harmful and can contribute to worsening lung damage. PMID:20303638

  4. Corrective Action Investigation Plan for Corrective Action Unit 569: Area 3 Yucca Flat Atmospheric Test Sites Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Patrick Matthews; Christy Sloop

    2012-02-01

    process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 569. The presence and nature of contamination at CAU 569 will be evaluated based on information collected from a field investigation. Radiological contamination will be evaluated based on a comparison of the total effective dose (TED) at sample locations to the dose-based final action level (FAL). The TED will be calculated as the total of separate estimates of internal and external dose. Results from the analysis of soil samples will be used to calculate internal radiological dose. Thermoluminescent dosimeters placed at the center of each sample location will be used to measure external radiological dose. A field investigation will be performed to define any areas where TED exceeds the FAL and to determine whether contaminants of concern are present at the site from other potential releases. The presence and nature of contamination from other types of releases (e.g., excavation, migration, and any potential releases discovered during the investigation) will be evaluated using soil samples collected from biased locations indicating the highest levels of contamination. Appendix A provides a detailed discussion of the DQO methodology and the objectives specific to each study group.

  5. Corrective Action Decision Document for Corrective Action Unit 562: Waste Systems Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Mark Krause

    2010-08-01

    This Corrective Action Decision Document (CADD) presents information supporting the selection of corrective action alternatives (CAAs) leading to the closure of Corrective Action Unit (CAU) 562, Waste Systems, in Areas 2, 23, and 25 of the Nevada Test Site, Nevada. This complies with the requirements of the Federal Facility Agreement and Consent Order (FFACO) that was agreed to by the State of Nevada; U.S. Department of Energy (DOE), Environmental Management; U.S. Department of Defense; and DOE, Legacy Management. Corrective Action Unit 562 comprises the following corrective action sites (CASs): • 02-26-11, Lead Shot • 02-44-02, Paint Spills and French Drain • 02-59-01, Septic System • 02-60-01, Concrete Drain • 02-60-02, French Drain • 02-60-03, Steam Cleaning Drain • 02-60-04, French Drain • 02-60-05, French Drain • 02-60-06, French Drain • 02-60-07, French Drain • 23-60-01, Mud Trap Drain and Outfall • 23-99-06, Grease Trap • 25-60-04, Building 3123 Outfalls The purpose of this CADD is to identify and provide the rationale for the recommendation of CAAs for the 13 CASs within CAU 562. Corrective action investigation (CAI) activities were performed from July 27, 2009, through May 12, 2010, as set forth in the CAU 562 Corrective Action Investigation Plan. The purpose of the CAI was to fulfill the following data needs as defined during the data quality objective (DQO) process: • Determine whether COCs are present. • If COCs are present, determine their nature and extent. • Provide sufficient information and data to complete appropriate corrective actions. A data quality assessment (DQA) performed on the CAU 562 data demonstrated the quality and acceptability of the data for use in fulfilling the DQO data needs. Analytes detected during the CAI were evaluated against appropriate final action levels (FALs) to identify the COCs for each CAS. The results of the CAI identified COCs at 10 of the 13 CASs in CAU 562, and thus corrective

  6. Study on the mechanism of action between dimethyl phthalate and herring sperm DNA at molecular level.

    PubMed

    Chi, Zhenxing; Wang, Donglin; You, Hong

    2016-08-01

    Dimethyl phthalate (DMP), a typical phthalic acid ester, is widespread in the environment and causes extensive concern due to its adverse effects on human health. To understand the genotoxicity of DMP at molecular level, the toxic interaction of DMP with herring sperm (hs) deoxyribonucleic acid (DNA; hs-DNA) was investigated in vitro under simulated physiological conditions using multi-spectroscopic techniques and a molecular modeling method. The results of Ultraviolet-Visible absorption spectroscopy, fluorescence emission spectroscopy, and circular dichroism spectra indicated that DMP interacts with hs-DNA in a groove-binding mode that changes the double helical structure of DNA. The binding constant and the number of binding sites calculated from the fluorescence quenching data were 565.718 L mol(-1) and 0.7872, respectively. A molecular modeling study revealed that DMP tends to bind with DNA in the A-T-rich regions of minor groove and that hydrogen bonding and van der Waals forces play main roles in the interaction. This research can help to elucidate the mechanism of DMP toxicity in vivo. PMID:27166703

  7. Relative impact of sea level rise, wave climate and anthropogenic actions on the recent shoreline changes of the Pacific Islands

    NASA Astrophysics Data System (ADS)

    Garcin, M.; Baills, A.; Yates, M.; Le Cozannet, G.; Bulteau, T.; Salai, E.; Sauter, J.

    2012-04-01

    Sea level rise is nowadays one of a major concern for many low-lying and highly populated areas in the world. However, it is difficult to forecast the consequences of sea levels rise in terms of erosion, due to the interactions with many forcing factors of the evolution of coastline mobility. Indeed, climatic factors such as sea level rise are combined with internal and external geodynamic processes, biological factors, wave forcing and anthropogenic actions which can also play an important role in coastline mobility. Understanding the whole system and its past evolutions is necessary to anticipate future changes. Within the on-going CECILE project, our goal is to evaluate the impact of future sea level change on some emblematic coasts located in different part of the world in order to assess their sensitivity and the variability of their response to different change rise rates. This work presents the study conducted on coastlines of two regions of the Pacific: French Polynesia (SW Pacific) and New Caledonia. In order to evaluate the sensitivity of the coastlines to sea level rise, we firstly analysed the response of each coastline during the sea level rise of the past 50 years, using a diachronic analysis of ancient and recent remote sensing images. Then we also took into account the evolution of anthropogenic actions contributing to modifications of the sedimentary budget at the coast, and finally, sea level variations, using the sea level reconstruction of Becker et al. (2012) of the 2nd half of the XXth century. Two atolls of French Polynesia (Manihi and Scilly) and six coastal stretches of New Caledonia have been studied. Although Manihi and Scilly experienced a sea level rise rate twice as important as the global mean according to Becker et al. (2012), wave forcing was, during the last 50 years, the dominant factor controlling the shoreline evolution and aggradation/erosion processes on the atolls. On the contrary, on the main island of New Caledonia, the

  8. Action Tweets Linked to Reduced County-Level HIV Prevalence in the United States: Online Messages and Structural Determinants.

    PubMed

    Ireland, Molly E; Chen, Qijia; Schwartz, H Andrew; Ungar, Lyle H; Albarracin, Dolores

    2016-06-01

    HIV is uncommon in most US counties but travels quickly through vulnerable communities when it strikes. Tracking behavior through social media may provide an unobtrusive, naturalistic means of predicting HIV outbreaks and understanding the behavioral and psychological factors that increase communities' risk. General action goals, or the motivation to engage in cognitive and motor activity, may support protective health behavior (e.g., using condoms) or encourage activity indiscriminately (e.g., risky sex), resulting in mixed health effects. We explored these opposing hypotheses by regressing county-level HIV prevalence on action language (e.g., work, plan) in over 150 million tweets mapped to US counties. Controlling for demographic and structural predictors of HIV, more active language was associated with lower HIV rates. By leveraging language used on social media to improve existing predictive models of geographic variation in HIV, future targeted HIV-prevention interventions may have a better chance of reaching high-risk communities before outbreaks occur. PMID:26650382

  9. Optomechanical effects of two-level systems in a back-action evading measurement of micro-mechanical motion

    SciTech Connect

    Suh, J.; Weinstein, A. J.; Schwab, K. C.

    2013-07-29

    We show that the two-level systems (TLS) in lithographic superconducting circuits act as a power-dependent dielectric leading to non-linear responses in a parametrically coupled electromechanical system. Driven TLS shift the microwave resonance frequency and modulate the mechanical resonance through the optical spring effect. By pumping with two tones in a back-action evading measurement, these effects produce a mechanical parametric instability which limits single quadrature imprecision to 1.4 x{sub zp}. The microwave resonator noise is also consistent to a TLS-noise model. These observations suggest design strategies for minimizing TLS effects to improve ground-state cooling and quantum non-demolition measurements of motion.

  10. Optomechanical effects of two-level systems in a back-action evading measurement of micro-mechanical motion

    NASA Astrophysics Data System (ADS)

    Suh, J.; Weinstein, A. J.; Schwab, K. C.

    2013-07-01

    We show that the two-level systems (TLS) in lithographic superconducting circuits act as a power-dependent dielectric leading to non-linear responses in a parametrically coupled electromechanical system. Driven TLS shift the microwave resonance frequency and modulate the mechanical resonance through the optical spring effect. By pumping with two tones in a back-action evading measurement, these effects produce a mechanical parametric instability which limits single quadrature imprecision to 1.4 xzp. The microwave resonator noise is also consistent to a TLS-noise model. These observations suggest design strategies for minimizing TLS effects to improve ground-state cooling and quantum non-demolition measurements of motion.

  11. A possible approach for setting a mercury risk-based action level based on tribal fish ingestion rates.

    PubMed

    Harper, Barbara L; Harris, Stuart G

    2008-05-01

    Risks from mercury and other contaminants in fish for a large Columbia River dataset are evaluated in this paper for a range of consumption rates. Extensive ethnohistorical, nutritional, recent ethnographic surveys, and other documentation was reviewed to confirm previous determinations that the traditional subsistence fish consumption rate is 500 pounds per capita annually, or 620 g per day (gpd). Lower comtemporary consumption rates for other population subsets are also discussed. The causes of the current suppression of fish consumption are discussed and the cultural, educational, social, and trade and economic impacts of the loss of fish are considered. Action levels for mercury for riverine Tribes in the Columbia Basin are suggested at 0.1 ppm or less based on the combined risk from mercury plus other contaminants, the higher fish consumption rates, the existing cultural deficit due to loss of salmon and other stressors, the health benefits of fish, and the cultural and economic importance of fish. The goal of fish advisories is to reduce fish consumption even further, which shifts the burden of avoiding risk to the very people who already bear the burdens of contaminant exposure, socio-economic impacts and cultural loss. However, because Tribal communities often do not have the choice of giving up more food, income, religion, culture, and heritage in order to avoid contamination, they are forced into choosing between culture and health. Many tribal members choose to incur chemical risk rather than giving up their culture and religion. We believe that lowering the action level for mercury is part of the federal fiduciary responsibility to American Indian Tribes. PMID:17631290

  12. Critical Care staffs' attitudes, confidence levels and educational needs correlate with countries' donation rates: data from the Donor Action database.

    PubMed

    Roels, Leo; Spaight, Caroline; Smits, Jacqueline; Cohen, Bernard

    2010-08-01

    To investigate on the impact of Critical Care (CC) staffs' attitudes to donation, their acceptance of the brain death (BD) concept, their confidence with donation-related tasks and educational needs on national donation rates. Donor Action (DA) Hospital Attitude Survey (HAS) data were collected from 19 537 CC staff in 11 countries, including personal attitudes to donation, self-reported knowledge, involvement and comfort levels with donation-related tasks and educational requirements. Countries' donation performance was expressed as Procurement Efficiency Index (PEI) (organs procured and transplanted/deaths from eligible causes). National PEI rates correlated well with CC staffs' average support to donation (R = 0.700, P = 0.014), acceptance of the BD concept (R = 0.742, P = 0.007), confidence levels (R = 0.796, P = 0.002) and average educational requirements with donation-related tasks (R = -0.661, P = 0.025). Nurses reported significantly lower positive attitudes (P < 0.0001), acceptance of the BD concept (P < 0.0001), comfort levels (P < 0.0001) and requested more education (P = 0.0025) than medical staff members. DA's HAS is a powerful, standardized tool to assess CC staffs' attitudes and donation-related skills in different environments. Measures to improve countries' donation performance should focus on guidance and education of CC staff so as to ensure that all practitioners have sufficient knowledge and feel comfortable with donation-related issues. PMID:20210934

  13. Corrective Action Investigation Plan for Corrective Action Unit 567: Miscellaneous Soil Sites, Nevada National Security Site, Nevada, with ROTC 1 Revision 0

    SciTech Connect

    Matthews, Patrick K.

    2013-07-01

    at Atmospheric Test Site T-1 exceeds the final action level (FAL) and requires corrective action. The presence and nature of contamination outside the default contamination boundary at Atmospheric Test Site T-1 and all other CAU 567 CASs will be evaluated based on information collected from a field investigation. Radiological contamination will be evaluated based on a comparison of the TED at sample locations to the dose-based FAL. The TED will be calculated as the total of separate estimates of internal and external dose. Results from the analysis of soil samples will be used to calculate internal radiological dose. Thermoluminescent dosimeters placed at the center of each sample location will be used to measure external radiological dose. Appendix A provides a detailed discussion of the DQO methodology and the DQOs specific to each CAS.

  14. Action Potential Energetics at the Organismal Level Reveal a Trade-Off in Efficiency at High Firing Rates

    PubMed Central

    Gilmour, Kathleen M.; Moorhead, Mayron J.; Perry, Steve F.; Markham, Michael R.

    2014-01-01

    The energetic costs of action potential (AP) production constrain the evolution of neural codes and brain networks. Cellular-level estimates of AP-related costs are typically based on voltage-dependent Na+ currents that drive active transport by the Na+/K+ ATPase to maintain the Na+ and K+ ion concentration gradients necessary for AP production. However, these estimates of AP cost have not been verified at the organismal level. Electric signaling in the weakly electric fish Eigenmannia virescens requires that specialized cells in an electric organ generate APs with large Na+ currents at high rates (200–600 Hz). We measured these currents using a voltage-clamp protocol and then estimated the energetic cost at the cellular level using standard methods. We then used this energy-intensive signaling behavior to measure changes in whole-animal energetics for small changes in electric discharge rate. At low rates, the whole-animal measure of AP cost was similar to our cellular-level estimates. However, AP cost increased nonlinearly with increasing firing rates. We show, with a biophysical model, that this nonlinearity can arise from the increasing cost of maintaining AP amplitude at high rates. Our results confirm that estimates of energetic costs based on Na+ influx are appropriate for low baseline firing rates, but that extrapolating to high firing rates may underestimate true costs in cases in which AP amplitude does not decrease. Moreover, the trade-off between energetic cost and firing rate suggests an additional constraint on the evolution of high-frequency signaling in neuronal systems. PMID:24381281

  15. Actions of mammalian insulin on a Neurospora variant: effects on intracellular metabolite levels as monitored by P-31 NMR spectroscopy

    SciTech Connect

    Greenfield, N.J.; McKenzie, M.A.; Jordan, F.; Takahashi, M.; Lenard, J.

    1986-05-01

    Fourier transform P-31 NMR spectroscopy (81 MHz) was used to investigate the biochemical nature of insulin action upon the cell wall-deficient slime mutant of Neurospora crassa. Spectra of oxygenated, living cells (ca.10/sup 9//ml.) in late logarithmic-early stationary phase of growth were accumulated for approximately 20 min. (350-450 pulses). Pronounced differences were seen in the metabolite levels of cells cultured for 18-21 hours in the presence of insulin (100 nM) as compared to cells cultured in its absence. Differences in the insulin-grown cells included higher levels of sugar phosphates, inorganic (cytoplasmic) phosphate, NAD+/NADH and UDP-glucose (UDPG) compared to control cells, in which UDP-N-acetylglucosamine (UDPNAG) was the prominent sugar nucleotide. When 100 mM glucose was administered with insulin immediately prior to measurement, short term effects were seen. There were significant increases of sugar phosphates, inorganic phosphate, NAD+/NADH, phosphodiesters and UDPG relative to the case of glucose addition alone. These results are wholly consistent with the known influence of insulin upon mammalian metabolism: stimulation of glucose uptake, phosphorylation and oxidation, phosphatide synthesis and Pi uptake.

  16. Test Area for Remedial Actions (TARA) site characterization and dynamic compaction of low-level radioactive waste trenches

    SciTech Connect

    Davis, E.C.; Spalding, B.P.; Lee, S.Y.; Hyder, L.K.

    1989-01-01

    As part of a low-level radioactive waste burial ground stabilization and closure technology demonstration project, a group of five burial trenches in Oak Ridge National Laboratory (ORNL) Solid Waste Storage Area (SWSA) 6 was selected as a demonstration site for testing trench compaction, trench grouting, and trench cap installation and performance. This report focuses on site characterization, trench compaction, and grout-trench leachate compatibility. Trench grouting and cap design and construction will be the subject of future reports. The five trenches, known as the Test Area for Remedial Actions (TARA) site, are contained within a hydrologically isolated area of SWSA 6; for that reason, any effects of stabilization activities on site performance and groundwater quality will be separable from the influence of other waste disposal units in SWSA 6. To obviate the chronic problem of burial trench subsidence and to provide support for an infiltration barrier cap, these five trenches were dynamically compacted by repeated dropping of a 4-ton weight onto each trench from heights of approximately 7 m.

  17. Optimisation of transgene action at the post-transcriptional level: high quality parthenocarpic fruits in industrial tomatoes

    PubMed Central

    Pandolfini, Tiziana; Rotino, Giuseppe L; Camerini, Serena; Defez, Roberto; Spena, Angelo

    2002-01-01

    Background Genetic engineering of parthenocarpy confers to horticultural plants the ability to produce fruits under environmental conditions that curtail fruit productivity and quality. The DefH9-iaaM transgene, whose predicted action is to confer auxin synthesis specifically in the placenta, ovules and derived tissues, has been shown to confer parthenocarpy to several plant species (tobacco, eggplant, tomato) and varieties. Results UC82 tomato plants, a typical cultivar used by the processing industry, transgenic for the DefH9-iaaM gene produce parthenocarpic fruits that are malformed. UC82 plants transgenic for the DefH9-RI-iaaM, a DefH9-iaaM derivative gene modified in its 5'ULR by replacing 53 nucleotides immediately upstream of the AUG initiation codon with an 87 nucleotides-long sequence derived from the rolA intron sequence, produce parthenocarpic fruits of high quality. In an in vitro translation system, the iaaM mRNA, modified in its 5'ULR is translated 3–4 times less efficiently than the original transcript. An optimal expressivity of parthenocarpy correlates with a reduced transgene mRNA steady state level in DefH9-RI-iaaM flower buds in comparison to DefH9-iaaM flower buds. Consistent with the known function of the iaaM gene, flower buds transgenic for the DefH9-RI-iaaM gene contain ten times more IAA than control untransformed flower buds, but five times less than DefH9-iaaM flower buds. Conclusions By using an auxin biosynthesis transgene downregulated at the post-transcriptional level, an optimal expressivity of parthenocarpy has been achieved in a genetic background not suitable for the original transgene. Thus, the method allows the generation of a wider range of expressivity of the desired trait in transgenic plants. PMID:11818033

  18. THE TWO-LEVEL THEORY OF VERB MEANING: AN APPROACH TO INTEGRATING THE SEMANTICS OF ACTION WITH THE MIRROR NEURON SYSTEM

    PubMed Central

    Kemmerer, David; Castillo, Javier Gonzalez

    2010-01-01

    Verbs have two separate levels of meaning. One level reflects the uniqueness of every verb and is called the “root.” The other level consists of a more austere representation that is shared by all the verbs in a given class and is called the “event structure template.” We explore the following hypotheses about how, with specific reference to the motor features of action verbs, these two distinct levels of semantic representation might correspond to two distinct levels of the mirror neuron system. Hypothesis 1: Root-level motor features of verb meaning are partially subserved by somatotopically mapped mirror neurons in the left primary motor and/or premotor cortices. Hypothesis 2: Template-level motor features of verb meaning are partially subserved by representationally more schematic mirror neurons in Brodmann area 44 of the left inferior frontal gyrus. Evidence has been accumulating in support of the general neuroanatomical claims made by these two hypotheses—namely, that each level of verb meaning is associated with the designated cortical areas. However, as yet no studies have satisfied all the criteria necessary to support the more specific neurobiological claims made by the two hypotheses—namely, that each level of verb meaning is associated with mirror neurons in the pertinent brain regions. This would require demonstrating that within those regions the same neuronal populations are engaged during (a) the linguistic processing of particular motor features of verb meaning, (b) the execution of actions with the corresponding motor features, and (c) the observation of actions with the corresponding motor features. PMID:18996582

  19. Changes in Levels of Affirmative Action in College Admissions in Response to Statewide Bans and Judicial Rulings

    ERIC Educational Resources Information Center

    Blume, Grant H.; Long, Mark C.

    2014-01-01

    Affirmative action in college admissions was effectively banned in Texas by the Hopwood ruling in 1997, by voter referenda in California and Washington in 1996 and 1998, and by administrative decisions in Florida in 1999. The "Hopwood" and "Johnson" rulings also had possible applicability to public colleges throughout Alabama,…

  20. Top-Level Players' Visual Control of Interceptive Actions: Bootsma and Van Wieringen (1990) 20 Years Later

    ERIC Educational Resources Information Center

    Bootsma, Reinoud J.; Fernandez, Laure; Morice, Antoine H. P.; Montagne, Gilles

    2010-01-01

    Using a two-step approach, Van Soest et al. (2010) recently questioned the pertinence of the conclusions drawn by Bootsma and Van Wieringen (1990) with respect to the visual regulation of an exemplary rapid interceptive action: the attacking forehand drive in table tennis. In the first step, they experimentally compared the movement behaviors of…

  1. Soils Project Risk-Based Corrective Action Evaluation Process with ROTC 1 and ROTC 2, Revision 0

    SciTech Connect

    Matthews, Patrick; Sloop, Christina

    2012-04-01

    This document formally defines and clarifies the NDEP-approved process the NNSA/NSO Soils Activity uses to fulfill the requirements of the FFACO and state regulations. This process is used to establish FALs in accordance with the risk-based corrective action (RBCA) process stipulated in Chapter 445 of the Nevada Administrative Code (NAC) as described in the ASTM International (ASTM) Method E1739-95 (NAC, 2008; ASTM, 1995). It is designed to provide a set of consistent standards for chemical and radiological corrective actions.

  2. The causal model approach to nutritional problems: an effective tool for research and action at the local level.

    PubMed Central

    Tonglet, R.; Mudosa, M.; Badashonderana, M.; Beghin, I.; Hennart, P.

    1992-01-01

    Reported are the results of a case study from Kirotshe rural health district, Northern Kivu, Zaire, where a workshop on the causal model approach to nutrition was organized in 1987. The model has since been used in the field for research design, training of health professionals, nutrition intervention, and community development. The rationale behind this approach is reviewed, the experience accumulated from Kirotshe district is described, and the ways in which the causal model contributes to comprehensive health and nutrition care are discussed. The broad range of possible policy implications of this approach underlines its usefulness for future action. PMID:1486667

  3. [An experimental study of the anti-inflammatory action of noopept and its effect on the level of cytokines].

    PubMed

    Alekseeva, S V; Kovalenko, L P; Tallerova, A V; Gudasheva, T A; Durnev, A D

    2012-01-01

    The anti-inflammatory effects of noopept (dipeptide analog of piracetam) upon a single intraperitoneal (i.p.) administration at doses of 1, 5, and 10 mg/kg in comparison to the reference drug diclofenac (10 mg/kg, i.p.) have been studied on a model of acute exudative inflammation induced by carrageenan in outbred rats and concanavalin A (Con A) in CBA mice. The level of cytokines was studied on the lipopolysaccharide (LPS) model (single administration, 100 mg/kg, i.p.) with 5-day administration of noopept at a dose of 5 mg/kg (i.p., before endotoxin injection) in C57BL/6 mice. The administration of noopept led to a significant suppression of the inflammatory response to both carrageenan and Con A. The administration of Con A caused a 16-fold increase in the level of IL-6 interleukin in the blood serum of mice as compared to control. Noopept (5 mg/kg) reduced the level of IL-6 by a factor of 1.8 in the inflammatory response to Con A. The administration of LPS led to pronounced increase in the levels ofpro-inflammatory IL-6 and TNF-alpha in the blood serum of test mice as compared to intact animals. The course administration of noopept (5 mg/kg) significantly decreased the level of IL-6 and reduced by half the level of TNF-alpha. PMID:23156084

  4. Methylmercury in fish: a review of residue levels, fish consumption and regulatory action in the United States

    SciTech Connect

    Tollefson, L.; Cordle, F.

    1986-09-01

    The dangers associated with the consumption of large amounts of methylmercury in fish are well recognized, and there is some evidence to suggest that methylmercury may be the cause of subtle neurological impairments when ingested at even low to moderate levels, particularly the prenatal and early childhood periods. This concern has prompted a continuing assessment of the risk of methylmercury toxicity among fish consumers in the US as well as other countries. The toxicokinetics of methylmercury in humans are reviewed and used to estimate body burdens associated with toxic effects. To determine seafood consumption patterns among the continental US population the Food and Drug Administration (FDA) has analyzed data from a diary study commissioned by the Tuna Research Foundation. Mercury residue levels in domestic fish sampled by the FDA were used to determine the level of exposure to methylmercury. Until evidence is presented that substantially lowers the known body burden of methylmercury which causes toxicity, calculations indicate that the current 1.0 ppm regulatory level provides adequate protection for the average fish consumer, for young children, and for a significant number of consumers exceeding the acceptable daily intake. However, additional studies are being carried out in a continuing process to ensure that safe levels of prenatal exposure to mercury residues in fish are maintained.

  5. SALS-linked WT-SOD1 adopts a highly similar helical conformation as FALS-causing L126Z-SOD1 in a membrane environment.

    PubMed

    Lim, Liangzhong; Song, Jianxing

    2016-09-01

    So far >180 mutations have been identified within the 153-residue human SOD1 to cause familial amyotrophic lateral sclerosis (FALS), while wild-type (WT) SOD1 was intriguingly implicated in sporadic ALS (SALS). SOD1 mutations lead to ALS by a dominant gain of cytotoxicity but its mechanism still remains elusive. Previously functional studies have revealed that SOD1 mutants became unexpectedly associated with organelle membranes. Indeed we decoded that the ALS-causing truncation mutant L126Z-SOD1 with an elevated toxicity completely loses the ability to fold into the native β-barrel structure but acquire a novel capacity to interact with membranes by forming helices over hydrophobic/amphiphilic segments. Very recently, the abnormal insertion of SOD1 mutants into ER membrane has been functionally characterized to trigger ER stress, an initial event of a cascade of cell-specific damages in ALS pathogenesis. Here we attempted to understand the mechanism for gain of cytotoxicity of the WT SOD1. We obtained atomic-resolution evidence that the nascent WT SOD1 without metalation and disulfide bridge is also highly disordered as L126Z. Most importantly, it owns the same capacity in interacting with membranes by forming very similar helices over the first 125 residues identical to L126Z-SOD1, plus an additional hydrophobic helix over Leu144-Ala152. Our study thus implies that the WT and mutant SOD1 indeed converge on a common mechanism for gain of cytotoxicity by abnormally interacting with membranes. Moreover, any genetic/environmental factors which can delay or impair its maturation might act to transform SOD1 into cytotoxic forms with the acquired capacity to abnormally interact with membranes. PMID:27378311

  6. "Growing Up" through the Middle Level Years: A Case Study in Leadership Actions Necessary to Meet Students' Needs

    ERIC Educational Resources Information Center

    Smith, M. Melissa Richard

    2010-01-01

    The purpose of this qualitative study was to examine the journey of a suburban middle level principal, as she led a school through an educational change process. This was a single case study design involving the school leader as principal participant, and the researcher as participant observer. The theoretical model that was developed for this…

  7. Influence of lipid heterogeneity and phase behavior on phospholipase A2 action at the single molecule level.

    PubMed

    Gudmand, Martin; Rocha, Susana; Hatzakis, Nikos S; Peneva, Kalina; Müllen, Klaus; Stamou, Dimitrios; Uji-I, Hiroshi; Hofkens, Johan; Bjørnholm, Thomas; Heimburg, Thomas

    2010-05-19

    We monitored the action of phospholipase A(2) (PLA(2)) on L- and D-dipalmitoyl-phosphatidylcholine (DPPC) Langmuir monolayers by mounting a Langmuir-trough on a wide-field fluorescence microscope with single molecule sensitivity. This made it possible to directly visualize the activity and diffusion behavior of single PLA(2) molecules in a heterogeneous lipid environment during active hydrolysis. The experiments showed that enzyme molecules adsorbed and interacted almost exclusively with the fluid region of the DPPC monolayers. Domains of gel state L-DPPC were degraded exclusively from the gel-fluid interface where the buildup of negatively charged hydrolysis products, fatty acid salts, led to changes in the mobility of PLA(2). The mobility of individual enzymes on the monolayers was characterized by single particle tracking. Diffusion coefficients of enzymes adsorbed to the fluid interface were between 3.2 microm(2)/s on the L-DPPC and 4.9 microm(2)/s on the D-DPPC monolayers. In regions enriched with hydrolysis products, the diffusion dropped to approximately 0.2 microm(2)/s. In addition, slower normal and anomalous diffusion modes were seen at the L-DPPC gel domain boundaries where hydrolysis took place. The average residence times of the enzyme in the fluid regions of the monolayer and on the product domain were between approximately 30 and 220 ms. At the gel domains it was below the experimental time resolution, i.e., enzymes were simply reflected from the gel domains back into solution. PMID:20441751

  8. Influence of Lipid Heterogeneity and Phase Behavior on Phospholipase A2 Action at the Single Molecule Level

    PubMed Central

    Gudmand, Martin; Rocha, Susana; Hatzakis, Nikos S.; Peneva, Kalina; Müllen, Klaus; Stamou, Dimitrios; Uji-I, Hiroshi; Hofkens, Johan; Bjørnholm, Thomas; Heimburg, Thomas

    2010-01-01

    Abstract We monitored the action of phospholipase A2 (PLA2) on L- and D-dipalmitoyl-phosphatidylcholine (DPPC) Langmuir monolayers by mounting a Langmuir-trough on a wide-field fluorescence microscope with single molecule sensitivity. This made it possible to directly visualize the activity and diffusion behavior of single PLA2 molecules in a heterogeneous lipid environment during active hydrolysis. The experiments showed that enzyme molecules adsorbed and interacted almost exclusively with the fluid region of the DPPC monolayers. Domains of gel state L-DPPC were degraded exclusively from the gel-fluid interface where the buildup of negatively charged hydrolysis products, fatty acid salts, led to changes in the mobility of PLA2. The mobility of individual enzymes on the monolayers was characterized by single particle tracking. Diffusion coefficients of enzymes adsorbed to the fluid interface were between 3.2 μm2/s on the L-DPPC and 4.9 μm2/s on the D-DPPC monolayers. In regions enriched with hydrolysis products, the diffusion dropped to ≈0.2 μm2/s. In addition, slower normal and anomalous diffusion modes were seen at the L-DPPC gel domain boundaries where hydrolysis took place. The average residence times of the enzyme in the fluid regions of the monolayer and on the product domain were between ≈30 and 220 ms. At the gel domains it was below the experimental time resolution, i.e., enzymes were simply reflected from the gel domains back into solution. PMID:20441751

  9. Addendum to the Closure Report for Corrective Action Unit 355: Area 2 Cellars/Mud Pits Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Lynn Kidman

    2008-10-01

    . Therefore, these URs were re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the URs) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove these URs because contamination is not present at these sites above the risk-based FALs. Requirements for inspecting and maintaining these URs will be canceled, and the postings and signage at each site will be removed. Fencing and posting may be present at these sites that are unrelated to the FFACO URs such as for radiological control purposes as required by the NV/YMP Radiological Control Manual (NNSA/NSO, 2004f). This modification will not affect or modify any non-FFACO requirements for fencing, posting, or monitoring at these sites.

  10. [Estimation of action of lactoovovegetarian and vegan diets on blood level of atherogenic lipoproteins in healthy people].

    PubMed

    Medkova, I L; Mosiakina, L I; Biriukova, L S

    2002-01-01

    The biochemical status of 72 vegetarians (aged 40-60) was studied; 35 persons kept to a lactoovovegetarian diet and 37 persons followed a vegan diet (vegetable food only). As the results of the investigation showed, almost all of the biochemical parameters of blood tests in the both groups were kept to the physiological norm. A pronounced hypolipidemic effect of both the diets was observed (the total cholesterol level was 5.24 +/- 0.28 mmol/l in the vegetarian group and 3.26 +/- 0.17 mmol/l in the vegan group), some parameters of lipid metabolism in the group of vegan being lower then in the vegetarian group. Thus, the total cholesterol level in the vegan group was lower by 38.7%, the atherogenic coefficient--by 13.8%, the low density cholesterol--by 34.3%, triglicerides--by 28.3%. Although the above mentioned parameters of the vegan group seem to be more satisfactory than those of the vegetarian group, we could not recommend the vegan diet for long periods of time because of deficiency of some nutrients in it. PMID:12462949

  11. Organization of goal-directed action at a high level of motor skill: the case of stone knapping in India.

    PubMed

    Biryukova, E V; Bril, B

    2008-07-01

    We analyzed the relationship between goal achievement and execution variability in craftsmen who have acquired the highest "ultimate" skills of stone knapping. The goal of a knapping movement is defined as the vector of the final velocity of a hammer, crucial for detaching a flake and, consequently, for the shape of the final product. The execution of the movement is defined by the kinematic pattern of the arm (i.e., by the coordination between the joint angles corresponding to the seven arm degrees of freedom). The results show that (a) the direction of final velocity is very stable for all craftsmen, whereas the amount of kinetic energy transmitted to the stone was craftsman specific and (b) the kinematic pattern of the arm was strongly individual and was a reliable sign of the level of skill--the highest level was characterized by the highest flexibility of movement kinematics. We stress the importance of conducting the experiment in natural conditions for better understanding of the relationship among the purpose (the final shape of the stone), the goal, and the execution of the movement. PMID:18698105

  12. Androgen action.

    PubMed

    Werner, Ralf; Holterhus, Paul-Martin

    2014-01-01

    Androgens are important for male sex development and physiology. Their actions are mediated by the androgen receptor (AR), a ligand-dependent nuclear transcription factor. The activity of the AR is controlled at multiple stages due to ligand binding and induced structural changes assisted by the foldosome, compartmentalization, recruitment of coregulators, posttranslational modifications and chromatin remodeling, leading to subsequent transcription of androgen-responsive target genes. Beside these short-term androgen actions, there is phenomenological and experimental evidence of long-term androgen programming in mammals and in the human during sensitive programming time windows, both pre- and postnatally. At the molecular level, research into androgen insensitivity syndrome has unmasked androgen programming at the transcriptome level, in genital fibroblasts and peripheral blood mononuclear cells, and at the epigenome level. Androgens are crucial for male sex development and physiology during embryogenesis, at puberty and in adult life. Testosterone and its more potent metabolite, dihydrotestosterone, which is converted from testosterone within the target cell by 5α-reductase II, are the main androgens involved in male sex differentiation. Androgen action is mediated by a single AR. The AR belongs to the nuclear receptor 3 group C, composed of the glucocorticoid receptor (NR3C1), mineralocorticoid receptor (NR3C2), progesterone receptor (NR3C3) and AR (NR3C4), and acts as a ligand-dependent transcription factor. PMID:25247642

  13. Oxidative stress mediates impairment of muscle function in transgenic mice with elevated level of wild-type Cu/Zn superoxide dismutase

    PubMed Central

    Peled-Kamar, M.; Lotem, J.; Wirguin, I.; Weiner, L.; Hermalin, A.; Groner, Y.

    1997-01-01

    Cases of familial amyotrophic lateral sclerosis (fALS; a neurodegenerative disorder) have been reported in which the gene for Cu/Zn superoxide dismutase (CuZnSOD) was mutated. Several studies with the fALS mutant CuZnSOD in transgenic mice and cells showed that the fALS mutations act through an as yet undefined dominant gain-of-function mechanism. Wild-type CuZnSOD catalyzes the dismutation of superoxide (O2⨪) but also produces hydroxyl radicals (•OH) with H2O2 as substrate. Two laboratories have recently demonstrated that the •OH production ability was preferentially enhanced by the fALS mutant CuZnSOD, suggesting that this might be the function gained in fALS. In this study, we used transgenic CuZnSOD (Tg-CuZnSOD) mice with elevated levels of CuZnSOD to determine whether overexpression of wild-type CuZnSOD was also associated with increased •OH production and impaired muscle function. Enhanced formation of •OH was detected, by spin trapping, in brain and muscle extracts of the Tg-CuZnSOD mice. Three independently derived Tg-CuZnSOD lines showed muscle abnormalities, reflected by altered electromyography (EMG) and diminished performance in the rope grip test. After treatment with paraquat (PQ), a widely used herbicide and O2⨪-generating compound, muscle disability significantly deteriorated in Tg-CuZnSOD mice but not in control mice. The results indicate that elevated levels of CuZnSOD cause indigenous long-term oxidative stress leading to impairment of muscle function. These findings may provide valuable clues about the concurred role of indigenous oxidative stress and exogenous agents in the etiology of sporadic ALS and several other neurodegenerative diseases in which a specific subset of neurons is affected. PMID:9108073

  14. Reversing the reduced level of endometrial GLUT4 expression in polycystic ovary syndrome: a mechanistic study of metformin action

    PubMed Central

    Li, Xin; Cui, Peng; Jiang, Hong-Yuan; Guo, Yan-Rong; Pishdari, Bano; Hu, Min; Feng, Yi; Billig, Håkan; Shao, Ruijin

    2015-01-01

    Conflicting results have been reported regarding whether or not insulin-regulated glucose transporter 4 (GLUT4) is expressed in human and rodent endometria. There is an inverse relationship between androgen levels and insulin-dependent glucose metabolism in women. Hyperandrogenemia, hyperinsulinemia, and insulin resistance are believed to contribute to endometrial abnormalities in women with polycystic ovary syndrome (PCOS). However, it has been unclear in previous studies if endometrial GLUT4 expression is regulated by androgen-dependent androgen receptors (ARs) and/or the insulin receptor/Akt/mTOR signaling network. In this study, we demonstrate that GLUT4 is expressed in normal endometrial cells (mainly in the epithelial cells) and is down-regulated under conditions of hyperandrogenemia in tissues from PCOS patients and in a 5α-dihydrotestosterone-induced PCOS-like rat model. Western blot analysis revealed reduced endometrial GLUT4 expression and increased AR expression in PCOS patients. However, the reduced GLUT4 level was not always associated with an increase in AR in PCOS patients when comparing non-hyperplasia with hyperplasia. Using a human tissue culture system, we investigated the molecular basis by which GLUT4 regulation in endometrial hyperplasia tissues is affected by metformin in PCOS patients. We show that specific endogenous organic cation transporter isoforms are regulated by metformin, and this suggests a direct effect of metformin on endometrial hyperplasia. Moreover, we demonstrate that metformin induces GLUT4 expression and inhibits AR expression and blocks insulin receptor/PI3K/Akt/mTOR signaling in the same hyperplasia human tissues. These findings indicate that changes in endometrial GLUT4 expression in PCOS patients involve the androgen-dependent alteration of AR expression and changes in the insulin receptor/PI3K/Akt/mTOR signaling network. PMID:26045896

  15. Reversing the reduced level of endometrial GLUT4 expression in polycystic ovary syndrome: a mechanistic study of metformin action.

    PubMed

    Li, Xin; Cui, Peng; Jiang, Hong-Yuan; Guo, Yan-Rong; Pishdari, Bano; Hu, Min; Feng, Yi; Billig, Håkan; Shao, Ruijin

    2015-01-01

    Conflicting results have been reported regarding whether or not insulin-regulated glucose transporter 4 (GLUT4) is expressed in human and rodent endometria. There is an inverse relationship between androgen levels and insulin-dependent glucose metabolism in women. Hyperandrogenemia, hyperinsulinemia, and insulin resistance are believed to contribute to endometrial abnormalities in women with polycystic ovary syndrome (PCOS). However, it has been unclear in previous studies if endometrial GLUT4 expression is regulated by androgen-dependent androgen receptors (ARs) and/or the insulin receptor/Akt/mTOR signaling network. In this study, we demonstrate that GLUT4 is expressed in normal endometrial cells (mainly in the epithelial cells) and is down-regulated under conditions of hyperandrogenemia in tissues from PCOS patients and in a 5α-dihydrotestosterone-induced PCOS-like rat model. Western blot analysis revealed reduced endometrial GLUT4 expression and increased AR expression in PCOS patients. However, the reduced GLUT4 level was not always associated with an increase in AR in PCOS patients when comparing non-hyperplasia with hyperplasia. Using a human tissue culture system, we investigated the molecular basis by which GLUT4 regulation in endometrial hyperplasia tissues is affected by metformin in PCOS patients. We show that specific endogenous organic cation transporter isoforms are regulated by metformin, and this suggests a direct effect of metformin on endometrial hyperplasia. Moreover, we demonstrate that metformin induces GLUT4 expression and inhibits AR expression and blocks insulin receptor/PI3K/Akt/mTOR signaling in the same hyperplasia human tissues. These findings indicate that changes in endometrial GLUT4 expression in PCOS patients involve the androgen-dependent alteration of AR expression and changes in the insulin receptor/PI3K/Akt/mTOR signaling network. PMID:26045896

  16. Improving Diversity and Educational Outreach at the K-14 level: A Call to Action for the AGU Membership

    NASA Astrophysics Data System (ADS)

    Hall, F. R.; Johnson, R.

    2002-12-01

    In 2002, the Subcommittee on Diversity (SD) of the Committee on Education and Human Resources (CEHR) submitted a Diversity Plan to the leadership of AGU. This plan outlines specific programs and goals that AGU can follow to help improve diversity in the Earth and space sciences. Diversity issues are key components to improve the human resource potential in the geosciences. As women are the majority population, and racial and ethnic minorities are experiencing the largest growing segment of the United States population, it is within our best interest to actively recruit and retain these populations into our dynamic fields of study. The SD recognizes that the strength of the AGU lies within its membership. Composed of some of the brightest and talented scientists in the world, the AGU members are leaders and pioneers in our understanding of the Earth System. Yet, many, if not most, people within underrepresented communities are not aware of the relevance that the Earth and space sciences play in their lives. In this discussion, we will discuss the importance of the AGU membership in the Diversity Plan. In addition, we will outline specific things that AGU members can do to improve access of US students and citizenry to Earth and space science education. These steps require that AGU members become active advocates in the public, especially at the K-14 level.

  17. Metabonomic analysis of the joint toxic action of long-term low-level exposure to a mixture of four organophosphate pesticides in rat plasma.

    PubMed

    Du, Longfei; Li, Sifan; Qi, Lei; Hou, Yurong; Zeng, Yan; Xu, Wei; Wang, Hong; Zhao, Xiujuan; Sun, Changhao

    2014-05-01

    In previously published articles, we evaluated the toxicity of four organophosphate (OP) pesticides (dichlorvos, dimethoate, acephate, and phorate) in rats using metabonomic technology at their corresponding no observed adverse effect levels (NOAELs). The results show that a single pesticide did not elicit a toxic response. The joint toxic action of four pesticides (at their corresponding NOAELs) was evaluated by metabolomic analysis of rat plasma under experimental conditions similar to those of the four single OP pesticides. The pesticides were administered daily to rats through drinking water for 24 weeks. The mixture of four pesticides showed a joint toxic action at the NOAELs of each pesticide. The 19 metabolites were statistically significantly changed in all the treated groups compared with those in the control group (p < 0.05 or p < 0.01). Exposure to OP pesticides resulted in increased lysoPC (15 : 0/0 : 0), lysoPC (16 : 0/0 : 0), lysoPC (O-18 : 0/0 : 0), lysoPC (P-19 : 1(12Z)/0 : 0), lysoPC (18 : 1(9Z)/0 : 0), lysoPC (18 : 0/0 : 0), lysoPC (20 : 4(5Z, 8Z, 11Z, 14Z)/0 : 0), lysoPE (16 : 0/0 : 0), lysoPC (17 : 0/0 : 0), 4-pyridoxic acid, glutamic acid, glycocholic acid, and arachidonic acid, as well as decreased C16 sphinganine, C17 sphinganine, phytosphingosine, indoleacrylic acid, tryptophan, and iodotyrosine in rat plasma. The results indicate that the mixture of OP pesticides induced oxidative stress, liver and renal dysfunction, disturbed the metabolism of lipids and amino acids, and interfered with the function of the thyroid gland. The present plasma results provided complementarities with our previous metabolomic analysis of the rat urine profile exposed to a mixture of four OP pesticides, and also contributed to the understanding of the mechanism of joint toxic action. PMID:24626741

  18. Nonperturbative renormalization of the axial current in Nf=3 lattice QCD with Wilson fermions and a tree-level improved gauge action

    NASA Astrophysics Data System (ADS)

    Bulava, John; Della Morte, Michele; Heitger, Jochen; Wittemeier, Christian

    2016-06-01

    We nonperturbatively determine the renormalization factor of the axial vector current in lattice QCD with Nf=3 flavors of Wilson-clover fermions and the tree-level Symanzik-improved gauge action. The (by now standard) renormalization condition is derived from the massive axial Ward identity, and it is imposed among Schrödinger functional states with large overlap on the lowest lying hadronic state in the pseudoscalar channel, in order to reduce kinematically enhanced cutoff effects. We explore a range of couplings relevant for simulations at lattice spacings of ≈0.09 fm and below. An interpolation formula for ZA(g02) , smoothly connecting the nonperturbative values to the 1-loop expression, is provided together with our final results.

  19. Impact of the Positive Action program on school-level indicators of academic achievement, absenteeism, and disciplinary outcomes: A matched-pair, cluster randomized, controlled trial

    PubMed Central

    Snyder, Frank; Vuchinich, Samuel; Acock, Alan; Washburn, Isaac; Beets, Michael; Li, Kin-Kit

    2010-01-01

    This paper reports the effects of a comprehensive elementary school-based social-emotional and character education program on school-level achievement, absenteeism, and disciplinary outcomes utilizing a matched-pair, cluster randomized, controlled design. The Positive Action Hawai‘i trial included 20 racially/ethnically diverse schools (mean enrollment = 544) and was conducted from the 2002-03 through the 2005-06 academic years. Using school-level archival data, analyses comparing change from baseline (2002) to one-year post trial (2007) revealed that intervention schools scored 9.8% better on the TerraNova (2nd ed.) test for reading and 8.8% on math; 20.7% better in Hawai‘i Content and Performance Standards scores for reading and 51.4% better in math; and that intervention schools reported 15.2% lower absenteeism and fewer suspensions (72.6%) and retentions (72.7%). Overall, effect sizes were moderate to large (range 0.5-1.1) for all of the examined outcomes. Sensitivity analyses using permutation models and random-intercept growth curve models substantiated results. The results provide evidence that a comprehensive school-based program, specifically developed to target student behavior and character, can positively influence school-level achievement, attendance, and disciplinary outcomes concurrently. PMID:20414477

  20. Component-Level Electronic-Assembly Repair (CLEAR) Analysis of the Problem Reporting and Corrective Action (PRACA) Database of the International Space Station On-Orbit Electrical Systems

    NASA Technical Reports Server (NTRS)

    Oeftering, Richard C.; Bradish, Martin A.; Juergens, Jeffrey R.; Lewis, Michael J.

    2011-01-01

    The NASA Constellation Program is investigating and developing technologies to support human exploration of the Moon and Mars. The Component-Level Electronic-Assembly Repair (CLEAR) task is part of the Supportability Project managed by the Exploration Technology Development Program. CLEAR is aimed at enabling a flight crew to diagnose and repair electronic circuits in space yet minimize logistics spares, equipment, and crew time and training. For insight into actual space repair needs, in early 2008 the project examined the operational experience of the International Space Station (ISS) program. CLEAR examined the ISS on-orbit Problem Reporting and Corrective Action database for electrical and electronic system problems. The ISS has higher than predicted reliability yet, as expected, it has persistent problems. A goal was to identify which on-orbit electrical problems could be resolved by a component-level replacement. A further goal was to identify problems that could benefit from the additional diagnostic and test capability that a component-level repair capability could provide. The study indicated that many problems stem from a small set of root causes that also represent distinct component problems. The study also determined that there are certain recurring problems where the current telemetry instrumentation and built-in tests are unable to completely resolve the problem. As a result, the root cause is listed as unknown. Overall, roughly 42 percent of on-orbit electrical problems on ISS could be addressed with a component-level repair. Furthermore, 63 percent of on-orbit electrical problems on ISS could benefit from additional external diagnostic and test capability. These results indicate that in situ component-level repair in combination with diagnostic and test capability can be expected to increase system availability and reduce logistics. The CLEAR approach can increase the flight crew s ability to act decisively to resolve problems while reducing

  1. Free heme pool and activity of key enzyme of heme synthesis in the rat liver under action of agents affecting reduced glutathione level.

    PubMed

    Barannik, T V; Inshina, N M; Kaliman, P A

    2005-01-01

    The decrease of GSH level in the rat liver was found to be accompanied by an increase of tryptophan 2,3-dioxygenase (TDO) heme saturation during first hours after HgCl2, phenylhydrazine (Ph) injection or rhabdomyolysis (the coefficient of correlation -0.978). The activity of the key enzyme of heme synthesis--5-aminolevulinate synthase (ALAS) was 2.5-fold increased in the first hours after Ph injection and rhabdomyolysis. Glutathione injection in vivo as well as CdCl2 caused the increase of GSH content and the inhibition of ALAS. The coefficient of correlation for GSH content and ALAS activity under the action of agents altering both these parameters (CdCl2, Ph, GSH injection and rhabdomyolysis) is 0.938. Taking into account the presence of heme regulatory motif with conserved cystein in many proteins, including ALAS and TDO (accession number in SwissProt database AAH61793 and P21643, respectively), the link between alterations of GSH content, ALAS activity and heme saturation of TDO in the rat liver could be proposed. The further experiments should be performed in order to elucidate the mechanisms of GSH level influence on free heme pool formation in the liver cells. PMID:16846079

  2. Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels.

    PubMed

    Reddy, I A; Pino, J A; Weikop, P; Osses, N; Sørensen, G; Bering, T; Valle, C; Bluett, R J; Erreger, K; Wortwein, G; Reyes, J G; Graham, D; Stanwood, G D; Hackett, T A; Patel, S; Fink-Jensen, A; Torres, G E; Galli, A

    2016-01-01

    Agonism of the glucagon-like peptide 1 (GLP-1) receptor (GLP-1R) has been effective at treating aspects of addictive behavior for a number of abused substances, including cocaine. However, the molecular mechanisms and brain circuits underlying the therapeutic effects of GLP-1R signaling on cocaine actions remain elusive. Recent evidence has revealed that endogenous signaling at the GLP-1R within the forebrain lateral septum (LS) acts to reduce cocaine-induced locomotion and cocaine conditioned place preference, both considered dopamine (DA)-associated behaviors. DA terminals project from the ventral tegmental area to the LS and express the DA transporter (DAT). Cocaine acts by altering DA bioavailability by targeting the DAT. Therefore, GLP-1R signaling might exert effects on DAT to account for its regulation of cocaine-induced behaviors. We show that the GLP-1R is highly expressed within the LS. GLP-1, in LS slices, significantly enhances DAT surface expression and DAT function. Exenatide (Ex-4), a long-lasting synthetic analog of GLP-1 abolished cocaine-induced elevation of DA. Interestingly, acute administration of Ex-4 reduces septal expression of the retrograde messenger 2-arachidonylglycerol (2-AG), as well as a product of its presynaptic degradation, arachidonic acid (AA). Notably, AA reduces septal DAT function pointing to AA as a novel regulator of central DA homeostasis. We further show that AA oxidation product γ-ketoaldehyde (γ-KA) forms adducts with the DAT and reduces DAT plasma membrane expression and function. These results support a mechanism in which postsynaptic septal GLP-1R activation regulates 2-AG levels to alter presynaptic DA homeostasis and cocaine actions through AA. PMID:27187231

  3. Streamlined Approach for Environmental Restoration Plan for Corrective Action Unit 121: Storage Tanks and Miscellaneous Sites, Nevada Test Site, Nevada

    SciTech Connect

    NSTec Environmental Restoration

    2007-06-01

    AST, with chemicals or radioactivity above action levels. CAS 12-22-26 has different potential closure pathways that are dependent upon the concentrations and chemicals detected. If only petroleum hydrocarbons are detected above action levels, then the area will be use-restricted. It will not be excavated because of the more significant hazard of excavating within a URMA. Similarly, polychlorinated biphenyls (PCBs) will only be excavated for concentrations of 50 parts per million (ppm) or greater, if there are no other factors that require excavation. For PCBs at concentrations above 1 ppm, the area will be use-restricted as required by Title 40, Code of Federal Regulations (CFR) Part 761 for PCBs (CFR, 2006), in the ''Toxic Substances Control Act'' (TSCA). Other chemicals at concentrations above the final action levels (FALs) will be excavated. If radioactivity is above action levels, then the soil will be excavated only to a depth of 1 foot (ft) below ground surface (bgs) and replaced with clean fill. This action is intended to remove the ''hot spot'' on the surface caused by leakage from a drum, and not to remediate the URMA.

  4. Choosing Actions

    PubMed Central

    Rosenbaum, David A.; Chapman, Kate M.; Coelho, Chase J.; Gong, Lanyun; Studenka, Breanna E.

    2013-01-01

    Actions that are chosen have properties that distinguish them from actions that are not. Of the nearly infinite possible actions that can achieve any given task, many of the unchosen actions are irrelevant, incorrect, or inappropriate. Others are relevant, correct, or appropriate but are disfavored for other reasons. Our research focuses on the question of what distinguishes actions that are chosen from actions that are possible but are not. We review studies that use simple preference methods to identify factors that contribute to action choices, especially for object-manipulation tasks. We can determine which factors are especially important through simple behavioral experiments. PMID:23761769

  5. High level waste storage tank farms/242-A evaporator standards/requirements identification document phase 1 assessment corrective actions/compliance schedule approval report

    SciTech Connect

    Biebesheimer, E.

    1996-09-30

    This document, the Standards/Requirements Identification Document (S/RID) Phase I Assessment Corrective Actions/Compliance Schedule Approval Report for the subject facility, contains the corrective actions required to bring the facility into compliance as a result of an Administrative Assessment to determine whether S/RID requirements are fully addressed by existing policies, plans or procedures. These actions are delineated in the Compliance Schedule Approvals which also contain; noncompliances, risks, compensatory measures, schedules for corrective actions, justifications for approval, and resource impacts.

  6. Test Area for Remedial Actions (TARA) site characterization and dynamic compaction of low-level radioactive waste trenches. FY 1988 progress report

    SciTech Connect

    Davis, E.C.; Spalding, B.P.; Lee, S.Y.; Hyder, L.K.

    1989-01-01

    As part of a low-level radioactive waste burial ground stabilization and closure technology demonstration project, a group of five burial trenches in Oak Ridge National Laboratory (ORNL) Solid Waste Storage Area (SWSA) 6 was selected as a demonstration site for testing trench compaction, trench grouting, and trench cap installation and performance. This report focuses on site characterization, trench compaction, and grout-trench leachate compatibility. Trench grouting and cap design and construction will be the subject of future reports. The five trenches, known as the Test Area for Remedial Actions (TARA) site, are contained within a hydrologically isolated area of SWSA 6; for that reason, any effects of stabilization activities on site performance and groundwater quality will be separable from the influence of other waste disposal units in SWSA 6. To obviate the chronic problem of burial trench subsidence and to provide support for an infiltration barrier cap, these five trenches were dynamically compacted by repeated dropping of a 4-ton weight onto each trench from heights of approximately 7 m.

  7. Closure Report for Corrective Action Unit 121: Storage Tanks and Miscellaneous Sites, Nevada Test Site, Nevada

    SciTech Connect

    NSTec Environmental Restoration

    2008-09-01

    determined to not likely have originated from the tank. Additional sample results showed that the compounds were likely present as a result of degraded asphalt around the adjacent, active water tank and not from the abandoned AST; therefore, they were not considered COCs. As a BMP, the empty AST was removed and disposed as sanitary waste. No COCs were present at CAS 12-22-26; therefore, no further action was chosen as the corrective action alternative. Although TPH was present at concentrations that exceeded the PAL, the volatile organic compound and SVOC hazardous constituents of TPH did not exceed the final action levels (FALs); therefore, TPH was not considered a COC. As a BMP, the empty AST was removed and disposed as sanitary waste. Closure activities generated sanitary waste, petroleum hydrocarbon PCB remediation waste, PCB remediation waste, and hazardous waste. Waste was appropriately managed and disposed. Waste that is currently staged on site is being appropriately managed and will be disposed under approved waste profiles in permitted landfills. Waste minimization activities included waste characterization sampling and segregation of waste streams.

  8. An Extended Model of Reasoned Action to Understand the Influence of Individual- and Network-Level Factors on African Americans’ Participation in HIV Vaccine Research

    PubMed Central

    Frew, Paula M.; Archibald, Matthew; Diallo, Dazon Dixon; Hou, Su-I; Horton, Takeia; Chan, Kayshin; Mulligan, Mark J.; del Rio, Carlos

    2010-01-01

    In the United States, the number and proportion of HIV/AIDS cases among black/African Americans continue to highlight the need for new biomedical prevention interventions, including an HIV vaccine, microbicide, or new antiretroviral (ARV) prevention strategies such as pre-exposure prophylaxis (PrEP) to complement existing condom usage, harm reduction methods, and behavioral change strategies to stem the HIV epidemic. Although black/African Americans are disproportionately impacted by HIV/AIDS, their participation in HIV clinical research continues to have unique challenges. We theorize that interaction among multilevel factors creates ideal alignment for minority participation in HIV clinical studies. Thus, we initially set out to test an extended model of reasoned action with 362 participants to understand the interplay of sociopsychological and network-level considerations influencing minority participation in HIV prevention research efforts. In this study, we linked the intrapersonal dimensions of attitudes, beliefs, and normative concerns to community-level components, appraisal of involvement with the clinical research organization, an entity which operates within a networked structure of community partner agencies, and identification with coalition advocacy aims. Various participatory outcomes were explored including involvement in future HIV vaccine community functions, participation in community promotion of HIV vaccine research, and community mobilization. Three-stage least squares estimates indicated similar findings across three models. Significant effects demonstrate the importance of positive attitudes toward HIV vaccine research, favorable health research beliefs, perceived social support for participation, HIV/AIDS issue engagement, and perceived relevance of the clinical research site’s mission and values. Identification of these nuanced pathway effects provides implications for tailored community program development. PMID:20012200

  9. The development of applied action levels for soil contact: a scenario for the exposure of humans to soil in a residential setting.

    PubMed Central

    Sedman, R M

    1989-01-01

    The California Site Mitigation Decision Tree Manual, 1985, was developed by the California Department of Health Services to provide a detailed technical basis for managing uncontrolled hazardous waste sites. The Decision Tree describes a process that relies on criteria, Applied Action Levels (AALs) to evaluate and, if necessary, mitigate the impact of uncontrolled hazardous waste sites on the public health and the environment. AALs are developed for individual substances, species, and media of exposure. AALs have been routinely developed for the media of air and water; however, an approach for developing AALs for soil contact was lacking. Given that the air pathway for soil contact is addressed in AALs for air, two routes of exposure, ingestion and dermal contact, are addressed in developing AALs for soil contact. The approach assumes a lifetime of exposure to soil in a residential setting. Age-related changes in exposure are included in the scenario. Exposure to soil due to ingestion and dermal contact are quantitated independently and then integrated in the final exposure scenario. A mass balance approach using four elements is employed to quantitate soil ingestion for a young child. Changes in soil ingestion with age are based on age-related changes in blood lead concentration and mouthing behavior. Dermal exposure to soil was determined from studies that reported skin soil load and from estimates of exposed skin surface area. Age-related changes in the dermal exposure to soil are also based on changes with age of blood lead concentration and mouthing behavior. The estimates of exposure to soil due to ingestion and dermal contact are integrated, and an approach for developing AALs is advanced. AALs are derived by allocating the Maximum Exposure Level as described in the Decision Tree to the average daily exposure to soil. Toxicokinetic considerations for the two routes of exposure must be included in deriving AALs for the soil medium of exposure. PMID:2651104

  10. Polybrominated diphenyl ether (DE-71) interferes with thyroid hormone action independent of effects on circulating levels of thyroid hormone in male rats.

    PubMed

    Bansal, Ruby; Tighe, Daniel; Danai, Amin; Rawn, Dorothea F K; Gaertner, Dean W; Arnold, Doug L; Gilbert, Mary E; Zoeller, R Thomas

    2014-10-01

    Polybrominated diphenyl ethers (PBDEs) are routinely found in human tissues including cord blood and breast milk. PBDEs may interfere with thyroid hormone (TH) during development, which could produce neurobehavioral deficits. An assumption in experimental and epidemiological studies is that PBDE effects on serum TH levels will reflect PBDE effects on TH action in tissues. To test whether this assumption is correct, we performed the following experiments. First, five concentrations of diphenyl ether (0-30 mg/kg) were fed daily to pregnant rats to postnatal day 21. PBDEs were measured in dam liver and heart to estimate internal dose. The results were compared with a separate study in which four concentrations of propylthiouracil (PTU; 0, 1, 2, and 3 ppm) was provided to pregnant rats in drinking water for the same duration as for diphenyl ether. PBDE exposure reduced serum T4 similar in magnitude to PTU, but serum TSH was not elevated by PBDE. PBDE treatment did not affect the expression of TH response genes in the liver or heart as did PTU treatment. PTU treatment reduced T4 in liver and heart, but PBDE treatment reduced T4 only in the heart. Tissue PBDEs were in the micrograms per gram lipid range, only slightly higher than observed in human fetal tissues. Thus, PBDE exposure reduces serum T4 but does not produce effects on tissues typical of low TH produced by PTU, demonstrating that the effects of chemical exposure on serum T4 levels may not always be a faithful proxy measure of chemical effects on the ability of thyroid hormone to regulate development and adult physiology. PMID:25060363

  11. Polybrominated Diphenyl Ether (DE-71) Interferes With Thyroid Hormone Action Independent of Effects on Circulating Levels of Thyroid Hormone in Male Rats

    PubMed Central

    Bansal, Ruby; Tighe, Daniel; Danai, Amin; Rawn, Dorothea F. K.; Gaertner, Dean W.; Arnold, Doug L.; Gilbert, Mary E.

    2014-01-01

    Polybrominated diphenyl ethers (PBDEs) are routinely found in human tissues including cord blood and breast milk. PBDEs may interfere with thyroid hormone (TH) during development, which could produce neurobehavioral deficits. An assumption in experimental and epidemiological studies is that PBDE effects on serum TH levels will reflect PBDE effects on TH action in tissues. To test whether this assumption is correct, we performed the following experiments. First, five concentrations of diphenyl ether (0–30 mg/kg) were fed daily to pregnant rats to postnatal day 21. PBDEs were measured in dam liver and heart to estimate internal dose. The results were compared with a separate study in which four concentrations of propylthiouracil (PTU; 0, 1, 2, and 3 ppm) was provided to pregnant rats in drinking water for the same duration as for diphenyl ether. PBDE exposure reduced serum T4 similar in magnitude to PTU, but serum TSH was not elevated by PBDE. PBDE treatment did not affect the expression of TH response genes in the liver or heart as did PTU treatment. PTU treatment reduced T4 in liver and heart, but PBDE treatment reduced T4 only in the heart. Tissue PBDEs were in the micrograms per gram lipid range, only slightly higher than observed in human fetal tissues. Thus, PBDE exposure reduces serum T4 but does not produce effects on tissues typical of low TH produced by PTU, demonstrating that the effects of chemical exposure on serum T4 levels may not always be a faithful proxy measure of chemical effects on the ability of thyroid hormone to regulate development and adult physiology. PMID:25060363

  12. Intentional Action and Action Slips.

    ERIC Educational Resources Information Center

    Heckhausen, Heinz; Beckmann, Jurgen

    1990-01-01

    An explanation of action slips is offered that examines controlled actions in the context of an intentional behavior theory. Actions are considered guided by mentally represented intentions, subdivided into goal intentions and contingent instrumental intentions. Action slips are categorized according to problem areas in the enactment of goal…

  13. Use of the reciprocal calculation procedure for setting workplace emergency action levels for hydrocarbon mixtures and their relationship to lower explosive limits.

    PubMed

    Gardner, Ron

    2012-04-01

    This paper proposes a novel use of the reciprocal calculation procedure (RCP) to calculate workplace emergency action levels (WEALs) for accidental releases of hydrocarbon mixtures. WEALs are defined here as the concentration in air that area monitors should alarm at to provide adequate warning and be sufficiently protective of health to allow at least enough time to don respiratory protective equipment (RPE) and escape. The rationale for the approach is analysed, and ways of defining suitable substance group guidance values (GVs) for input into the RCP are considered and compared. WEAL GVs could be based on: 3× RCP GVs (i.e. using the 3× rule), the 5× RCP GVs (i.e. using the 5× rule for calculating ceiling values), emergency exposure limits, or immediately dangerous to life or health values (IDLHs). Of these, the method of choice is to base WEAL GVs on health-based IDLH values, which were developed for emergency situations in the workplace. However, IDLHs have only been set for 11 hydrocarbons, so the choice of GVs is also informed by comparison with possible GVs based on the other approaches. Using the proposed GVs, WEALs were calculated for various hydrocarbon mixtures, and the way they vary with the composition of the mixture was examined. Also, the level of health protection given by the current practice of setting emergency area alarms in the oil and gas industry at 10% of the lower explosive limit (LEL) was tested by comparing this with the WEAL. In the event of an accidental release, this comparison suggests that, provided that aromatics constitute <50% of the mixture, an alarm set at 10% LEL should provide adequate warning and be sufficiently protective of health to at allow at least enough time to don RPE and escape. In the absence of better information or specific acute toxicity concerns (such as the presence of hydrogen sulphide), it is proposed that the WEALs be used as a guide for assessing the adequacy of area alarm levels in respect of warning

  14. Adult Literacy Action Campaign: Projects around Australia. A Review of State and Territory Level Adult Literacy Projects Funded under the Adult Literacy Action Campaign of the National Policy on Languages. Occasional Paper Number 3.

    ERIC Educational Resources Information Center

    Australian Advisory Council on Languages and Multicultural Education, Canberra.

    This collection of papers is a review of the adult literacy projects in Australia funded under the 1987-89 Adult Literacy Action Campaign (ALAC) of the National Policy on Languages. Fourteen authors describe various literacy projects and, often, their outcomes. The projects described are grouped in seven areas. On the subject of Literacy Training…

  15. Evaluating IMRT and VMAT dose accuracy: Practical examples of failure to detect systematic errors when applying a commonly used metric and action levels

    SciTech Connect

    Nelms, Benjamin E.; Chan, Maria F.; Jarry, Geneviève; Lemire, Matthieu; Lowden, John; Hampton, Carnell

    2013-11-15

    Purpose: This study (1) examines a variety of real-world cases where systematic errors were not detected by widely accepted methods for IMRT/VMAT dosimetric accuracy evaluation, and (2) drills-down to identify failure modes and their corresponding means for detection, diagnosis, and mitigation. The primary goal of detailing these case studies is to explore different, more sensitive methods and metrics that could be used more effectively for evaluating accuracy of dose algorithms, delivery systems, and QA devices.Methods: The authors present seven real-world case studies representing a variety of combinations of the treatment planning system (TPS), linac, delivery modality, and systematic error type. These case studies are typical to what might be used as part of an IMRT or VMAT commissioning test suite, varying in complexity. Each case study is analyzed according to TG-119 instructions for gamma passing rates and action levels for per-beam and/or composite plan dosimetric QA. Then, each case study is analyzed in-depth with advanced diagnostic methods (dose profile examination, EPID-based measurements, dose difference pattern analysis, 3D measurement-guided dose reconstruction, and dose grid inspection) and more sensitive metrics (2% local normalization/2 mm DTA and estimated DVH comparisons).Results: For these case studies, the conventional 3%/3 mm gamma passing rates exceeded 99% for IMRT per-beam analyses and ranged from 93.9% to 100% for composite plan dose analysis, well above the TG-119 action levels of 90% and 88%, respectively. However, all cases had systematic errors that were detected only by using advanced diagnostic techniques and more sensitive metrics. The systematic errors caused variable but noteworthy impact, including estimated target dose coverage loss of up to 5.5% and local dose deviations up to 31.5%. Types of errors included TPS model settings, algorithm limitations, and modeling and alignment of QA phantoms in the TPS. Most of the errors were

  16. Therapeutic Action of Fluoxetine is Associated with a Reduction in Prefrontal Cortical miR-1971 Expression Levels in a Mouse Model of Posttraumatic Stress Disorder

    PubMed Central

    Schmidt, Ulrike; Herrmann, Leonie; Hagl, Kathrin; Novak, Bozidar; Huber, Christine; Holsboer, Florian; Wotjak, Carsten T.; Buell, Dominik R.

    2013-01-01

    MicroRNAs (miRNA) are a class of small non-coding RNAs that have recently emerged as epigenetic modulators of gene expression in psychiatric diseases like schizophrenia and major depression. So far, miRNAs have neither been studied in patients suffering from posttraumatic stress disorder (PTSD) nor in PTSD animal models. Here, we present the first study exploring the connection between miRNAs and PTSD. Employing our previously established PTSD mouse model, we assessed miRNA profiles in prefrontal cortices (PFCs) dissected from either fluoxetine or control-treated wildtype C57BL/6N mice 74 days after their subjection to either a single traumatic electric footshock or mock-treatment. Fluoxetine is an antidepressant known to be effective both in PTSD patients and in mice suffering from a PTSD-like syndrome. Screening for differences in the relative expression levels of all potential miRNA target sequences of miRBase 18.0 by pairwise comparison of the PFC miRNA profiles of the four mouse groups mentioned resulted in identification of five miRNA candidate molecules. Validation of these miRNA candidates by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) revealed that the therapeutic action of fluoxetine in shocked mice is associated with a significant reduction in mmu-miR-1971 expression. Furthermore, our findings suggest that traumatic stress and fluoxetine interact to cause distinct alterations in the mouse PFC miRNA signature in the long-term. PMID:23847554

  17. A service-level action research intervention to improve identification and treatment of cannabis and related mental health issues in young Indigenous Australians: a study protocol

    PubMed Central

    Bohanna, India; Bird, Katrina; Copeland, Jan; Roberts, Nicholas; Clough, Alan

    2014-01-01

    Introduction Regular cannabis use is associated with negative mental health impacts including psychosis, depression and anxiety. Rates of cannabis use have increased in Aboriginal and Torres Strait Islander communities in northern Australia within the last two decades, presenting a significant increased risk to young people's mental health in these regions. Improved screening, early detection and treatment for cannabis-related mental health issues are urgently required. This paper describes a service-level action research intervention and evaluation protocol for use in the few services where it is possible to engage young Aboriginal and Torres Strait Islander Australians. Methods/Design The protocol is being developed in two services where youth mental health is core business: a primary healthcare centre and a youth service in the Cairns and hinterland region, far north Queensland. The protocol calls first for baseline data to be collected using staff and client surveys; network mapping; and analysis of screening, treatment and referral rates. The protocol's intervention phase is driven by service needs identified from baseline data. Intervention strategies focus on implementing/enhancing cannabis screening instruments and processes in line with current best practice; enhancing networks with external drug and mental health services; developing culturally acceptable training and resources; developing activities aiming to reduce cannabis use in young Aboriginal and Torres Strait Islander clients using the services. The protocol requires implementation of the multilevel intervention within each service for 1 year, with follow-up data then collected and compared to baseline. Process evaluation identifies the more effective intervention strategies and documents the challenges to be overcome for full implementation. Ethics and dissemination Ethics approval was provided by The James Cook University, Human Research Ethics Committee. Ethics Approval Number H5322. Peer

  18. Environmental Action.

    ERIC Educational Resources Information Center

    Lott, Jesse; Allen, Rodney F.

    This booklet, a general guide to citizen eco-action, discusses a plan of action on community environmental problems. It offers factors to be considered in any community eco-action situation, but it is not a rigid set of rules. An overview identifies seven key ideas of environmental issues, including the universal participation of all humans in the…

  19. Assessment of personal and community-level exposures to particulate matter among children with asthma in Detroit, Michigan, as part of Community Action Against Asthma (CAAA).

    PubMed Central

    Keeler, Gerald J; Dvonch, Timothy; Yip, Fuyuen Y; Parker, Edith A; Isreal, Barbara A; Marsik, Frank J; Morishita, Masako; Barres, James A; Robins, Thomas G; Brakefield-Caldwell, Wilma; Sam, Mathew

    2002-01-01

    We report on the research conducted by the Community Action Against Asthma (CAAA) in Detroit, Michigan, to evaluate personal and community-level exposures to particulate matter (PM) among children with asthma living in an urban environment. CAAA is a community-based participatory research collaboration among academia, health agencies, and community-based organizations. CAAA investigates the effects of environmental exposures on the residents of Detroit through a participatory process that engages participants from the affected communities in all aspects of the design and conduct of the research; disseminates the results to all parties involved; and uses the research results to design, in collaboration with all partners, interventions to reduce the identified environmental exposures. The CAAA PM exposure assessment includes four seasonal measurement campaigns each year that are conducted for a 2-week duration each season. In each seasonal measurement period, daily ambient measurements of PM2.5 and PM10 (particulate matter with a mass median aerodynamic diameter less than 2.5 microm and 10 microm, respectively) are collected at two elementary schools in the eastside and southwest communities of Detroit. Concurrently, indoor measurements of PM2.5 and PM10 are made at the schools as well as inside the homes of a subset of 20 children with asthma. Daily personal exposure measurements of PM10 are also collected for these 20 children with asthma. Results from the first five seasonal assessment periods reveal that mean personal PM10 (68.4 39.2 microg/m(3)) and indoor home PM10 (52.2 30.6 microg/m(3)) exposures are significantly greater (p < 0.05) than the outdoor PM10 concentrations (25.8 11.8 microg/m(3)). The same was also found for PM2.5 (indoor PM2.5 = 34.4 21.7 microg/m(3); outdoor PM2.5 = 15.6 8.2 microg/m(3)). In addition, significant differences (p < 0.05) in community-level exposure to both PM10 and PM2.5 are observed between the two Detroit communities (southwest

  20. Application of the No Action Level (NAL) protocol to correct for prostate motion based on electronic portal imaging of implanted markers

    SciTech Connect

    Boer, Hans C.J. de . E-mail: j.deboer@erasmusmc.nl; Os, Marjolein J.H. van; Jansen, Peter P.; Heijmen, Ben J.M.

    2005-03-15

    Purpose: To evaluate the efficacy of the No Action Level (NAL) off-line correction protocol in the reduction of systematic prostate displacements as determined from electronic portal images (EPI) using implanted markers. Methods and materials: Four platinum markers, two near the apex and two near the base of the prostate, were implanted for localization purposes in patients who received fractionated high dose rate brachytherapy. During the following course of 25 fractions of external beam radiotherapy, the position of each marker relative to the corresponding position in digitally reconstructed radiographs (DRRs) was measured in EPI in 15 patients for on average 17 fractions per patient. These marker positions yield the composite displacements due to both setup error and internal prostate motion, relative to the planning computed tomography scan. As the NAL protocol is highly effective in reducing systematic errors (recurring each fraction) due to setup inaccuracy alone, we investigated its efficacy in reducing systematic composite displacements. The analysis was performed for the center of mass (COM) of the four markers, as well as for the cranial and caudal markers separately. Furthermore, the impact of prostate rotation on the achieved positioning accuracy was determined. Results: In case of no setup corrections, the standard deviations of the systematic composite displacements of the COM were 3-4 mm in the craniocaudal and anterior-posterior directions, and 2 mm in the left-right direction. The corresponding SDs of the random displacements (interfraction fluctuations) were 2-3 mm in each direction. When applying a NAL protocol based on three initial treatment fractions, the SDs of the systematic COM displacements were reduced to 1-2 mm. Displacements at the cranial end of the prostate were slightly larger than at the caudal end, and quantitative analysis showed this originates from left-right axis rotations about the prostate apex. Further analysis revealed

  1. Item-Level Psychometrics and Predictors of Performance for Spanish/English Bilingual Speakers on "An Object and Action Naming Battery"

    ERIC Educational Resources Information Center

    Edmonds, Lisa A.; Donovan, Neila J.

    2012-01-01

    Purpose: There is a pressing need for psychometrically sound naming materials for Spanish/English bilingual adults. To address this need, in this study the authors examined the psychometric properties of An Object and Action Naming Battery (An O&A Battery; Druks & Masterson, 2000) in bilingual speakers. Method: Ninety-one Spanish/English…

  2. Action Learning.

    ERIC Educational Resources Information Center

    1996

    These four papers were presented at a symposium on action learning moderated by Lex Dilworth at the 1996 conference of the Academy of Human Resource Development. "Developing an Infrastructure for Individual and Organizational Change: Transfer of Learning from an Action Reflection Learning (ARL) Program" (ARL Inquiry) reports findings from a study…

  3. Action of an electromagnetic pulse on a plasma with a high level of ion-acoustic turbulence. Field diffusion and subdiffusion

    SciTech Connect

    Ovchinnikov, K. N.; Uryupin, S. A.

    2013-09-15

    Specific features of the interaction of a relatively weak electromagnetic pulse with a nonisothermal current-carrying plasma in which the electron drift velocity is much higher than the ion-acoustic velocity, but lower than the electron thermal velocity, are studied. If the state of the plasma with ion-acoustic turbulence does not change during the pulse action, the field penetrates into the plasma in the ordinary diffusion regime, but the diffusion coefficient in this case is inversely proportional to the anomalous conductivity. If, during the pulse action, the particle temperatures and the current-driving field change due to turbulent heating, the field penetrates into the plasma in the subdiffusion regime. It is shown how the presence of subdiffusion can be detected by measuring the reflected field.

  4. Developing an Action Learning Design Model

    ERIC Educational Resources Information Center

    Bong, Hyeon-Cheol; Cho, Yonjoo; Kim, Hyung-Sook

    2014-01-01

    As the number of organizations implementing action learning increases, both successful and failed cases also increase in action learning practice in South Korea. Existing studies on action learning have listed key success factors of action learning at the program level or at the team level but have not paid sufficient attention to the program…

  5. Action spectrum for photocarcinogenesis.

    PubMed

    de Gruijl, F R

    1995-01-01

    The wavelength dependence of the carcinogenicity of ultraviolet (UV) radiation needs to be known in order to assess the carcinogenic risks of various UV sources, most notably the different solar UV spectra at ground level under depleting stratospheric ozone. This wavelength dependence cannot be extracted from human data (e.g., from epidemiology); it can, however, be directly obtained from animal experiments. Precise information on the wavelength dependence, the so-called action spectrum, was not available until recently: erythemal or mutagenic action spectra have been used as substitutes. However, experimental data on skin tumors induced in hairless mice (Skh:HR1) with various polychromatic sources have been building up. Our group has found that none of the substitute action spectra yield a statistically acceptable description of our data, and we have, therefore, derived a new action spectrum, dubbed the SCUP action spectrum (SCUP stands for Skin Cancer Utrecht-Philadelphia, because the action spectrum also fits experimental data from the former Skin and Cancer Hospital in Philadelphia). The SCUP action spectrum has a maximum at 293 nm, and in the UVA region above 340 nm the relative carcinogenicity per J/m2 drops to about 10(-4) of this maximum. The effects of an ozone depletion on solar UV doses weighted with these different action spectra are compared: the erythemal and SCUP weighted dose come out as least sensitive with a 1.3% and 1.4% increase, respectively, for every 1% decrease in ozone. PMID:7597292

  6. Determination of the melt level from a real weight signal during computer-assisted crystal growth by the Stepanov (EFG) technique and the use of crucible motion as a control action

    NASA Astrophysics Data System (ADS)

    Rossolenko, S. N.; Stryukov, D. O.; Kurlov, V. N.

    2015-06-01

    The current melt level is determined from a real weight signal during computer-assisted crystal growth by the Stepanov technique. No knowledge of the real shape of growing crystals is necessary in this case. A numerical solution to the capillary Laplace equation is used to analyze the use of the motion of a crucible with a melt as a control action that affects the shapes of menisci and growing crystals.

  7. The Two-Level Theory of Verb Meaning: An Approach to Integrating the Semantics of Action with the Mirror Neuron System

    ERIC Educational Resources Information Center

    Kemmerer, David; Gonzalez-Castillo, Javier

    2010-01-01

    Verbs have two separate levels of meaning. One level reflects the uniqueness of every verb and is called the "root". The other level consists of a more austere representation that is shared by all the verbs in a given class and is called the "event structure template". We explore the following hypotheses about how, with specific reference to the…

  8. Action perception predicts action performance

    PubMed Central

    Bailey, Heather R.; Kurby, Christopher A.; Giovannetti, Tania; Zacks, Jeffrey M.

    2013-01-01

    Everyday action impairments often are observed in demented older adults, and they are common potential barriers to functional independence. We evaluated whether the ability to segment and efficiently encode activities is related to the ability to execute activities. Further, we evaluated whether brain regions important for segmentation also were important for action performance. Cognitively healthy older adults and those with very mild or mild dementia of the Alzheimer's type watched and segmented movies of everyday activities and then completed the Naturalistic Action Test. Structural MRI was used to measure volume in the dorsolateral prefrontal cortex (DLPFC), medial temporal lobes (MTL), posterior cortex, and anterior cingulate cortex (ACC). Dementia status and the ability to segment everyday activities strongly predicted naturalistic action performance, and MTL volume largely accounted for this relationship. In addition, the current results supported the Omission-Commission Model: Different cognitive and neurological mechanisms predicted different types of action error. Segmentation, dementia severity, and MTL volume predicted everyday omission errors, DLPFC volume predicted commission errors, and ACC volume predicted action additions. These findings suggest that event segmentation may be critical for effective action production, and that the segmentation and production of activities may recruit the same event representation system. PMID:23851113

  9. Controlling the level of the sonic boom generated by a flying vehicle by means of cryogenic forcing. 3. Physical justification of the cryogenic action

    NASA Astrophysics Data System (ADS)

    Fomin, V. M.; Chirkashenko, V. F.; Volkov, V. F.; Kharitonov, A. M.

    2011-05-01

    The influence of the basic factors of cryogenic forcing on formation of the middle zone on the sonic boom and aerodynamic characteristics of the flying vehicle is studied by experimental and numerical methods. Experimental data obtained with alcohol or liquid nitrogen as an injected liquid are used for comparisons; as a result, the total effect of temperature and coolant evaporation can be determined. The influence of temperature is studied by means of numerical simulations of the cryogenic action of distributed injection of air. A comparison of numerical and experimental data reveals the effect of the coolant evaporation process on perturbed flow formation. It is demonstrated that evaporation of the coolant outgoing onto the vehicle surface should be intensified to increase the efficiency of cryogenic forcing (to decrease the coolant flow rate).

  10. Delving into Egocentric Actions

    PubMed Central

    Li, Yin; Ye, Zhefan; Rehg, James M.

    2016-01-01

    We address the challenging problem of recognizing the camera wearer's actions from videos captured by an egocentric camera. Egocentric videos encode a rich set of signals regarding the camera wearer, including head movement, hand pose and gaze information. We propose to utilize these mid-level egocentric cues for egocentric action recognition. We present a novel set of egocentric features and show how they can be combined with motion and object features. The result is a compact representation with superior performance. In addition, we provide the first systematic evaluation of motion, object and egocentric cues in egocentric action recognition. Our benchmark leads to several surprising findings. These findings uncover the best practices for egocentric actions, with a significant performance boost over all previous state-of-the-art methods on three publicly available datasets. PMID:26973427

  11. Self-inhibiting action of nortriptylin's antidepressive effect at high plasma levels: a randomized double-blind study controlled by plasma concentrations in patients with endogenous depression.

    PubMed

    Kragh-Sorensen, P; Hansen, C E; Baastrup, P C; Hvidberg, E F

    1976-02-01

    Below the toxic plasma level of nortriptyline (NT) an upper therapeutic limit has been postulated in patients with endogenous depression. If so the clinical significance is obvious and a double-blind, randomized study was performed in order to solve this problem. Two groups of patients were controlled at different plasma levels (less than 150 ng/ml and less than 180 ng/ml). The degree of depression was rated weekly. Only about one third (n equals 24) of the patients originally included, were carried through the full protocol, the most prominent reason for drop out beeing spontaneous remission during an initial placebo period. After 4 weeks of NT treatment the majority in the high level group was still depressed, but the difference barely significant (P equals 5.5%). However, a randomized reduction of the plasma level among the patients at the high level resulted in a significant correlation to remission. Evaluation of the total material after 6 weeks of NT treatment demonstrated a strong correlation of high plasma level to poor antidepressive effect of NT. No correlation could be obtained between side-effects, which were few, and plasma level. The non-proteinbound fraction in plasma was found to 7% (SD 1.83) by simultaneous determinations of NT in plasma and CSF in 13 patients. The variation in the proteinbinding was not likely to invalidate the over all results based on total NT determination. A therapeutic plasma range of 50-150 ng/ml is recommended. PMID:766041

  12. Action, human.

    PubMed

    Russo, M T

    2010-01-01

    The term "human action" designates the intentional and deliberate movement that is proper and exclusive to mankind. Human action is a unified structure: knowledge, intention or volition, deliberation, decision or choice of means and execution. The integration between these dimensions appears as a task that demands strength of will to achieve the synthesis of self-possession and self-control that enables full personal realisation. Recently, the debate about the dynamism of human action has been enriched by the contribution of neurosciences. Thanks to techniques of neuroimaging, neurosciences have expanded the field of investigation to the nature of volition, to the role of the brain in decision-making processes and to the notion of freedom and responsibility. PMID:20393686

  13. The accountability for reasonableness approach to guide priority setting in health systems within limited resources – findings from action research at district level in Kenya, Tanzania, and Zambia

    PubMed Central

    2014-01-01

    Background Priority-setting decisions are based on an important, but not sufficient set of values and thus lead to disagreement on priorities. Accountability for Reasonableness (AFR) is an ethics-based approach to a legitimate and fair priority-setting process that builds upon four conditions: relevance, publicity, appeals, and enforcement, which facilitate agreement on priority-setting decisions and gain support for their implementation. This paper focuses on the assessment of AFR within the project REsponse to ACcountable priority setting for Trust in health systems (REACT). Methods This intervention study applied an action research methodology to assess implementation of AFR in one district in Kenya, Tanzania, and Zambia, respectively. The assessments focused on selected disease, program, and managerial areas. An implementing action research team of core health team members and supporting researchers was formed to implement, and continually assess and improve the application of the four conditions. Researchers evaluated the intervention using qualitative and quantitative data collection and analysis methods. Results The values underlying the AFR approach were in all three districts well-aligned with general values expressed by both service providers and community representatives. There was some variation in the interpretations and actual use of the AFR in the decision-making processes in the three districts, and its effect ranged from an increase in awareness of the importance of fairness to a broadened engagement of health team members and other stakeholders in priority setting and other decision-making processes. Conclusions District stakeholders were able to take greater charge of closing the gap between nationally set planning and the local realities and demands of the served communities within the limited resources at hand. This study thus indicates that the operationalization of the four broadly defined and linked conditions is both possible and seems to

  14. Action Research

    ERIC Educational Resources Information Center

    Milton-Brkich, Katie Lynn; Shumbera, Kristen; Beran, Becky

    2010-01-01

    Defined as "any systemic inquiry conducted by teachers... for the purpose of gathering information about how their particular schools operate, how they teach, and how their students learn" (Mertler, 2009), "action research" is empowering and professional research done by teachers to inform and improves their own practices. Although there are many…

  15. Cognitive framing in action.

    PubMed

    Huhn, John M; Potts, Cory Adam; Rosenbaum, David A

    2016-06-01

    Cognitive framing effects have been widely reported in higher-level decision-making and have been ascribed to rules of thumb for quick thinking. No such demonstrations have been reported for physical action, as far as we know, but they would be expected if cognition for physical action is fundamentally similar to cognition for higher-level decision-making. To test for such effects, we asked participants to reach for a horizontally-oriented pipe to move it from one height to another while turning the pipe 180° to bring one end (the "business end") to a target on the left or right. From a physical perspective, participants could have always rotated the pipe in the same angular direction no matter which end was the business end; a given participant could have always turned the pipe clockwise or counter-clockwise. Instead, our participants turned the business end counter-clockwise for left targets and clockwise for right targets. Thus, the way the identical physical task was framed altered the way it was performed. This finding is consistent with the hypothesis that cognition for physical action is fundamentally similar to cognition for higher-level decision-making. A tantalizing possibility is that higher-level decision heuristics have roots in the control of physical action, a hypothesis that accords with embodied views of cognition. PMID:26970853

  16. Nutrition Action Pack.

    ERIC Educational Resources Information Center

    Sockut, Joanne; Stumpe, Stephanie

    One of five McDonald's Action Packs, these instructional materials integrate elementary school-level nutrition education into other disciplines--biology, sociology, physiology, mathematics, and art. Contents include four units consisting of twelve activities. Unit 1, Why You Need Food, is a self-examination of what is needed for growth, health,…

  17. SYRACUSE ACTION FOR YOUTH.

    ERIC Educational Resources Information Center

    ADDINGTON, HAROLD E.; AND OTHERS

    A PROPOSAL WAS MADE TO PREVENT AND CONTROL JUVENILE DELINQUENCY BY OPENING OPPORTUNITIES AND DEVELOPING COMPETENCE AMONG DISADVANTAGED YOUTH. THE TOTAL COMMUNITY WAS MOBILIZED TO DEVELOP A PROGRAM TO ATTACK THE PROBLEM AT ALL LEVELS THEY WORKED FOR 18 MONTHS TO PLAN A SERIES OF CREATIVE ACTION PROGRAMS IN EDUCATION, EMPLOYMENT, AND COMMUNITY…

  18. Court Action for Migrants.

    ERIC Educational Resources Information Center

    Ewald, Thomas R.

    Aiding attorneys who represent migrant farmworkers and their families when affirmative civil action is required, this book helps to raise the level of migrants' legal protection to a minimum standard of adequacy. The text is based on the Federal Rules of Civil Procedure, a national set of rules. The book is divided into 3 sections: the…

  19. Action for Children's Television.

    ERIC Educational Resources Information Center

    Ranly, Donald P.

    The origins, development, and effectiveness of Action for Children's Television (ACT) are examined in this pamphlet. The strategies used by ACT to obtain change at the congressional level and within television stations and networks include the following: a "tuneout" day when people are urged to turn off their television sets, a boycott of certain…

  20. Student Perceptions of Science Teacher Actions in Two Culturally Diverse Middle-Level Science Classrooms: A Case Study in the American Deep South.

    ERIC Educational Resources Information Center

    McGinnis, J. Randy

    The purpose of this study was to give voice to students' perceptions in two science classrooms taught by two white teachers in an urban multicultural middle-level school situated in the American Deep South. Student participants were 35 students of different ethnicities in grades 7 and 8. The theoretical reference used is social contextual, a…

  1. Citizen's actions

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The role played by individual citizens as consumers of energy was examined, with emphasis on studying ways in which their action could result in energy conservation. It was shown that there are ways that energy can be conserved in this way, with citizens acting either individually or in groups. The potential savings are significant, but the actual savings may be quite small. The citizens need to be motivated to save and to believe in a conservation ethic; developing such an ethic is difficult, and perhaps not responsive to the shotgun approach now being attempted. The true course of action may be to synthesize new societal structures that provide the maximum evolution of culture within the limitation of scarce energy resources.

  2. Actionable Nuggets

    PubMed Central

    McColl, Mary Ann; Aiken, Alice; Smith, Karen; McColl, Alexander; Green, Michael; Godwin, Marshall; Birtwhistle, Richard; Norman, Kathleen; Brankston, Gabrielle; Schaub, Michael

    2015-01-01

    Abstract Objective To present the results of a pilot study of an innovative methodology for translating best evidence about spinal cord injury (SCI) for family practice. Design Review of Canadian and international peer-reviewed literature to develop SCI Actionable Nuggets, and a mixed qualitative-quantitative evaluation to determine Nuggets’ effect on physician knowledge of and attitudes toward patients with SCI, as well as practice accessibility. Setting Ontario, Newfoundland, and Australia. Participants Forty-nine primary care physicians. Methods Twenty Actionable Nuggets (pertaining to key health issues associated with long-term SCI) were developed. Nugget postcards were mailed weekly for 20 weeks to participating physicians. Prior knowledge of SCI was self-rated by participants; they also completed an online posttest to assess the information they gained from the Nugget postcards. Participants’ opinions about practice accessibility and accommodations for patients with SCI, as well as the acceptability and usefulness of Nuggets, were assessed in interviews. Main findings With Actionable Nuggets, participants’ knowledge of the health needs of patients with SCI improved, as knowledge increased from a self-rating of fair (58%) to very good (75%) based on posttest quiz results. The mean overall score for accessibility and accommodations in physicians’ practices was 72%. Participants’ awareness of the need for screening and disease prevention among this population also increased. The usefulness and acceptability of SCI Nugget postcards were rated as excellent. Conclusion Actionable Nuggets are a knowledge translation tool designed to provide family physicians with concise, practical information about the most prevalent and pressing primary care needs of patients with SCI. This evidence-based resource has been shown to be an excellent fit with information consumption processes in primary care. They were updated and adapted for distribution by the Canadian

  3. NOTE: Dielectrophoretic analysis of changes in cytoplasmic ion levels due to ion channel blocker action reveals underlying differences between drug-sensitive and multidrug-resistant leukaemic cells

    NASA Astrophysics Data System (ADS)

    Duncan, L.; Shelmerdine, H.; Hughes, M. P.; Coley, H. M.; Hübner, Y.; Labeed, F. H.

    2008-01-01

    Dielectrophoresis (DEP)—the motion of particles in non-uniform AC fields—has been used in the investigation of cell electrophysiology. The technique offers the advantages of rapid determination of the conductance and capacitance of membrane and cytoplasm. However, it is unable to directly determine the ionic strengths of individual cytoplasmic ions, which has potentially limited its application in assessing cell composition. In this paper, we demonstrate how dielectrophoresis can be used to investigate the cytoplasmic ion composition by using ion channel blocking agents. By blocking key ion transporters individually, it is possible to determine their overall contribution to the free ions in the cytoplasm. We use this technique to evaluate the relative contributions of chloride, potassium and calcium ions to the cytoplasmic conductivities of drug sensitive and resistant myelogenous leukaemic (K562) cells in order to determine the contributions of individual ion channel activity in mediating multi-drug resistance in cancer. Results indicate that whilst K+ and Ca2+ levels were extremely similar between sensitive and resistant lines, levels of Cl- were elevated by three times to that in the resistant line, implying increased chloride channel activity. This result is in line with current theories of MDR, and validates the use of ion channel blockers with DEP to investigate ion channel function.

  4. THE SENSITIVITY OF CELLS WITH THE VARIOUS LEVEL OF NAD(P)H:QUINONE OXIDOREDUCTASE 1 TO CYTOTOXIC ACTION OF QUINONIMINES AND α-TOCOPHEROL SYNTHETIC DERIVATIVES.

    PubMed

    Petrova, G V; Parshykov, A V

    2015-01-01

    The effects of α-tocopherol with shortened to 6 carbon atoms side chain (α-Toc-C6), α-tocopherol succinate (α-TS) and quinonimine 2,6-dichlorophenolindophenol (DCPIP) on DT-diaphorase activity and viability of rat thymocytes, splenocytes and hepatocytes were investigated. It was shown that the lowest basal activity of the enzyme is inherent in splenocytes. In comparison to splenocytes, DT-diaphorase activity was 1.4 and 5 times higher in thymocytes and hepatocytes, respectively. It was found that the sensitivity of cells to the cytotoxic effect of DCPIP was inversely proportional to the basal level of DT-diaphorase activity and accompanied by its activation with subsequent inhibition at non-toxic and toxic concentrations, respectively. Hepatocytes were least sensitive to the cytotoxic effect of α-Toc-C6. In thymocytes and splenocytes α-Toc-C6 exerts inhibitory effects on DT-diaphorase, whereas in hepatocytes an increased activity of the enzyme was observed, which probably caused their high survival rate. Simultaneous induction of cytochrome P450 enzyme expression by α-Toc-C6 in hepatocytes is also possible. Cytotoxic effect of α-TS does not depend on the basal level of DT-diaphorase activity in cells, is not accompanied by its induction and it is most likely determined by the non-specific esterase activity. PMID:26547963

  5. The GROOP Effect: Groups Mimic Group Actions

    ERIC Educational Resources Information Center

    Tsai, Jessica Chia-Chin; Sebanz, Natalie; Knoblich, Gunther

    2011-01-01

    Research on perception-action links has focused on an interpersonal level, demonstrating effects of observing individual actions on performance. The present study investigated perception-action matching at an inter-group level. Pairs of participants responded to hand movements that were performed by two individuals who used one hand each or they…

  6. Action Learning: Avoiding Conflict or Enabling Action

    ERIC Educational Resources Information Center

    Corley, Aileen; Thorne, Ann

    2006-01-01

    Action learning is based on the premise that action and learning are inextricably entwined and it is this potential, to enable action, which has contributed to the growth of action learning within education and management development programmes. However has this growth in action learning lead to an evolution or a dilution of Revan's classical…

  7. Avulsion in action: Reconstruction and modelling sedimentation pace and upstream flood water levels following a Medieval tidal-river diversion catastrophe (Biesbosch, The Netherlands, 1421-1750 AD)

    NASA Astrophysics Data System (ADS)

    Kleinhans, Maarten G.; Weerts, Henk J. T.; Cohen, Kim M.

    2010-05-01

    Deltaic land inundated by storm surges may reform by sedimentation from natural or human-induced river diversions. This is a well-known trigger mechanism for creation of new channels in coastal plains and deltas, which may develop into main channels and lead to abandonment of older (avulsion), particularly in the downstream parts of deltas that host tidal rivers. These new channels develop as part of deltaic splay complexes that heal initial diversion scars and fill up flooded basins at a certain pace. We study a case with excellent historical and geological data of a diversion of the river Rhine following catastrophic inundations (1421-1424 AD) into medieval reclaimed land. Numerical modelling of deltaic splay and channel development is combined with reconstructions from historical maps and geological data. This yields detailed insight in pacing of splay sedimentation and changing hydrodynamics in the channel upstream of the diversion in the two centuries following the inundation. The equivalent of the full sand budget of the river Rhine was effectively trapped in the developing splay. The tidal-avulsion splay evolution on aspects is similar to that of fluvial crevassing into flood basins documented for settings lacking 'downstream' tidal control. The typical small-scale delta-lobe avulsion cycles: mouth bar formation, backward sedimentation, upstream avulsion, channel progradation and mouth bar formation are reproduced in the splay-modelling. The pacing of splay development, however, is relatively fast due to the presence of tides and the water depth in the receiving basin. The diversion had a strong upstream impact, in particular on water levels in the feeding river channel at stages of peak flow. For two centuries levels were significantly raised, because bifurcation-imposed reduced transport capacity and associated sedimentation at the diversion site increased hydraulic roughness and hampered flow. These findings have implications regarding flood mitigation

  8. Effect of a supportive-educative program in the math class for stress, anxiety, and depression in female students in the third level of junior high school: An action research

    PubMed Central

    Emamjomeh, Seyedeh Mahtab; Bahrami, Masoud

    2015-01-01

    Background and Aim: Students in junior high school, particularly in the third level, are prone to a variety of stressors. This in turn might lead to stress, anxiety, depression, and other health-related problems. There are a very limited number of action research studies to identify the effect of stress management techniques among students. Therefore, a study was conducted to assess the effect of a program used in the math class to decrease the student's level of stress, anxiety, and depression. Material and Methods: This was an action research study, which was conducted in region three of the Education and Training Office of Isfahan, in the year 2012. Fifty-one students in a junior high school were selected and underwent a comprehensive stress management program. This program was prepared in collaboration with the students, their parents, teachers, and managers of the school, and was implemented approximately during a four-month period. The student's stress, anxiety, and depression were measured before and after the program using the DASS-21 questionnaire. Findings: The t-test identified that the mean scores of stress, anxiety, and depression after the intervention were significantly lower than the corresponding scores before the program. One-way analysis of variance (ANOVA) also showed that the students from the veterans (Janbaz) families had higher levels of stress compared to their classmates, who belonged to the non-veteran families (P< 0.05). Results: Education and implementation of stress management techniques including cognitive and behavioral interventions along with active and collaborative methods of learning in the math class might be useful both inside and outside the class, for better management of stress and other health-related problems of students. PMID:25767821

  9. Pockmarks on either side of the Strait of Gibraltar: formation from overpressured shallow contourite gas reservoirs and internal wave action during the last glacial sea-level lowstand?

    NASA Astrophysics Data System (ADS)

    León, Ricardo; Somoza, Luis; Medialdea, Teresa; González, Francisco Javier; Gimenez-Moreno, Carmen Julia; Pérez-López, Raúl

    2014-06-01

    Integrating novel and published swath bathymetry (3,980 km2), as well as chirp and high-resolution 2D seismic reflection profiles (2,190 km), this study presents the mapping of 436 pockmarks at water depths varying widely between 370 and 1,020 m on either side of the Strait of Gibraltar. On the Atlantic side in the south-eastern Gulf of Cádiz near the Camarinal Sill, 198 newly discovered pockmarks occur in three well localized and separated fields: on the upper slope ( n=14), in the main channel of the Mediterranean outflow water (MOW, n=160), and on the huge contourite levee of the MOW main channel ( n=24) near the well-known TASYO field. These pockmarks vary in diameter from 60 to 919 m, and are sub-circular to irregularly elongated or lobate in shape. Their slope angles on average range from 3° to 25°. On the Mediterranean side of the strait on the Ceuta Drift of the western Alborán Basin, where pockmarks were already known to occur, 238 pockmarks were identified and grouped into three interconnected fields, i.e. a northern ( n=34), a central ( n=61) and a southern field ( n=143). In the latter two fields the pockmarks are mainly sub-circular, ranging from 130 to 400 m in diameter with slope angles averaging 1.5° to 15°. In the northern sector, by contrast, they are elongated up to 1,430 m, probably reflecting MOW activity. Based on seismo-stratigraphic interpretation, it is inferred that most pockmarks formed during and shortly after the last glacial sea-level lowstand, as they are related to the final erosional discontinuity sealed by Holocene transgressive deposits. Combining these findings with other existing knowledge, it is proposed that pockmark formation on either side of the Strait of Gibraltar resulted from gas and/or sediment pore-water venting from overpressured shallow gas reservoirs entrapped in coarse-grained contourites of levee deposits and Pleistocene palaeochannel infillings. Venting was either triggered or promoted by hydraulic pumping

  10. Effects of high levels of dietary zinc oxide on ex vivo epithelial histamine response and investigations on histamine receptor action in the proximal colon of weaned piglets.

    PubMed

    Kröger, S; Pieper, R; Aschenbach, J R; Martin, L; Liu, P; Rieger, J; Schwelberger, H G; Neumann, K; Zentek, J

    2015-11-01

    The aim of the study was to identify the effect of high dietary zinc oxide (ZnO) levels on the histamine-induced secretory-type response and histamine metabolism in the porcine proximal colon. After weaning at d 26, 3 diets with low (LZn), normal (NZn), and high (HZn) concentrations of zinc (57, 164, or 2,425 mg/kg) were fed to a total of 120 piglets. Digesta and tissue samples were taken from the ascending colon after 7 ± 1, 14 ± 1, 21 ± 1, and 28 ± 1 d. Partially stripped tissue was mounted in Ussing chambers, and histamine was applied either to the serosal or mucosal compartments. Tissue was pretreated with or without aminoguanidine and amodiaquine to block the histamine-degrading enzymes diamine oxidase (DAO) and histamine -methyltransferase (HMT), respectively. Gene expression and catalytic activity of DAO and HMT in the tissue were analyzed. The numbers of mast cells were determined in tissue samples, and histamine concentration was measured in the colon digesta. Colon tissue from another 12 piglets was used for functional studies on histamine H and H receptors by using the neuronal conduction blocker tetrodotoxin (TTX) and the H and H receptor blocker chloropyramine and famotidine, respectively. After serosal histamine application to colonic tissue in Ussing chambers, the change of short-circuit current (Δ) was not affected by pretreatment and was not different between Zn feeding groups. The Δ after mucosal histamine application was numerically lower ( = 0.168) in HZn compared to LZn and NZn pigs. Mast cell numbers increased from 32 to 46 d of life ( < 0.05). Further studies elucidated that the serosal histamine response was partly inhibited by chloropyramine or famotidine ( < 0.01). The response to mucosal histamine tended to be decreased when chloropyramine but not famotidine was applied from either the serosal or the mucosal side ( = 0.055). Tetrodotoxin alone or in combination with chloropyramine resulted in a similar reduction in the mucosal

  11. The role of action readiness in motivated behavior.

    PubMed

    Suri, Gaurav; Sheppes, Gal; Gross, James J

    2015-12-01

    According to many theories of motivation and decision making, the principal driver of human behavior is the valuation of actions. Action value is computed as the difference between stimulus value (the benefits and costs inherent in the stimulus that is the target of the action) and action costs (the effort required to perform the action). In the present work, we propose that action costs are crucially influenced by the readiness to perform a given action. We define action readiness as the ease with which an action may be initiated given the preaction launch state of the individual. An action that has been frequently or recently performed or rehearsed has a high level of action readiness, whereas an action that has not been frequently or recently performed or rehearsed has a low level of action readiness. By our account, if action readiness levels are high for a given action, decreased action costs may result in action even when the stimulus value is relatively low. Conversely, if action readiness levels are low for a given action, even action costs that appear negligible can dominate positive stimulus values, resulting in seemingly puzzling instances of inaction. We develop and test these ideas in 3 studies across 233 participants using an image-viewing decision context and a logistic prediction model. PMID:26436428

  12. Social Action As An Objective of Social Studies Instruction.

    ERIC Educational Resources Information Center

    Curtis, Charles K.

    This paper presents a rationale for making social action a major goal of elementary and secondary school social studies education. In addition, it describes social action models, suggests social action approaches appropriate for students at various grade levels, and reviews literature on social action by public school students. Social action is…

  13. The Take Action Project

    ERIC Educational Resources Information Center

    Boudreau, Sue

    2010-01-01

    The Take Action Project (TAP) was created to help middle school students take informed and effective action on science-related issues. The seven steps of TAP ask students to (1) choose a science-related problem of interest to them, (2) research their problem, (3) select an action to take on the problem, (4) plan that action, (5) take action, (6)…

  14. Action Research in Graduate Management Research Programs.

    ERIC Educational Resources Information Center

    Perry, Chad; Zuber-Skerritt, Ortun

    1992-01-01

    It is proposed that action research, as distinguished from traditional research, has a role in graduate management education. It is suggested that the former is more appropriate for developing managerial competencies. Differences between master's-level and doctoral-level action research projects are noted, and related issues for curriculum design…

  15. Action Learning at Work.

    ERIC Educational Resources Information Center

    Mumford, Alan, Ed.

    This book contains 34 papers examining the theory, process, and outcomes of action learning at work. The following papers are included: "An Introduction to the Text" (Alan Mumford); "The Learning Equation" (Reg Revans); "Action Learning as a Vehicle for Learning" (Alan Mumford); "Placing Action Learning and Action Research in Context" (Cliff…

  16. Action Research Facilitator's Handbook.

    ERIC Educational Resources Information Center

    Caro-Bruce, Cathy

    This handbook is a roadmap for action research facilitators to help groups as they work through the research process. It offers quotations, handouts, strategies, resources, and insights from actual experiences. The sections of the handbook follow the action research cycle, focusing on: "What is Action Research?"; "What is the Action Research…

  17. 29 CFR 30.4 - Affirmative action plans.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... these regulations, sponsors are expected to make appropriate adjustments in goal levels. See 29 CFR 30.8... affirmative action plan. (b) Definition of affirmative action. Affirmative action is not mere passive... affirmative action plan must also include adequate provision for outreach and positive recruitment that...

  18. Ecology and Energy Action Pack.

    ERIC Educational Resources Information Center

    McDonald's Corp., Oak Brook, IL.

    One of five McDonald's Action Packs, these elementary school-level instructional materials are for use as an introduction to existing units of study, supplements to a textbook, or a source of special projects for environmental education. Contents include these six units: Make Your Own Ecology Mini-spinner, Let's Look at a Food Chain, Drip the…

  19. Inferences about Action Engage Action Systems

    ERIC Educational Resources Information Center

    Taylor, Lawrence J.; Lev-Ari, Shiri; Zwaan, Rolf A.

    2008-01-01

    Verbal descriptions of actions activate compatible motor responses [Glenberg, A. M., & Kaschak, M. P. (2002). Grounding language in action. "Psychonomic Bulletin & Review, 9", 558-565]. Previous studies have found that the motor processes for manual rotation are engaged in a direction-specific manner when a verb disambiguates the direction of…

  20. Objects tell us what action we can expect: dissociating brain areas for retrieval and exploitation of action knowledge during action observation in fMRI

    PubMed Central

    Schubotz, Ricarda I.; Wurm, Moritz F.; Wittmann, Marco K.; von Cramon, D. Yves

    2014-01-01

    Objects are reminiscent of actions often performed with them: knife and apple remind us on peeling the apple or cutting it. Mnemonic representations of object-related actions (action codes) evoked by the sight of an object may constrain and hence facilitate recognition of unrolling actions. The present fMRI study investigated if and how action codes influence brain activation during action observation. The average number of action codes (NAC) of 51 sets of objects was rated by a group of n = 24 participants. In an fMRI study, different volunteers were asked to recognize actions performed with the same objects presented in short videos. To disentangle areas reflecting the storage of action codes from those exploiting them, we showed object-compatible and object-incompatible (pantomime) actions. Areas storing action codes were considered to positively co-vary with NAC in both object-compatible and object-incompatible action; due to its role in tool-related tasks, we here hypothesized left anterior inferior parietal cortex (aIPL). In contrast, areas exploiting action codes were expected to show this correlation only in object-compatible but not incompatible action, as only object-compatible actions match one of the active action codes. For this interaction, we hypothesized ventrolateral premotor cortex (PMv) to join aIPL due to its role in biasing competition in IPL. We found left anterior intraparietal sulcus (IPS) and left posterior middle temporal gyrus (pMTG) to co-vary with NAC. In addition to these areas, action codes increased activity in object-compatible action in bilateral PMv, right IPS, and lateral occipital cortex (LO). Findings suggest that during action observation, the brain derives possible actions from perceived objects, and uses this information to shape action recognition. In particular, the number of expectable actions quantifies the activity level at PMv, IPL, and pMTG, but only PMv reflects their biased competition while observed action unfolds

  1. The Challenge of Evaluating Action Learning

    ERIC Educational Resources Information Center

    Edmonstone, John

    2015-01-01

    The paper examines the benefits claimed for action learning at individual, organisational and inter-organisational levels. It goes on to identify both generic difficulties in evaluating development programmes and action learning specifically. The distinction between formative and summative evaluation is considered and a summative evaluation…

  2. Outdoor Recreation Action. Report No. 10

    ERIC Educational Resources Information Center

    Bureau of Outdoor Recreation (Dept. of Interior), Washington, DC.

    Actions taken in the area of outdoor recreation on Federal, State, local, and private levels are reported in the document. Financing actions are listed according to states, government agencies, and names of private financers. The organization and administration section includes new agencies, personnel, reorganizations, and significant resolutions…

  3. Putting Action in Perspective

    ERIC Educational Resources Information Center

    Lozano, Sandra C.; Hard, Bridgette Martin; Tversky, Barbara

    2007-01-01

    Embodied approaches to cognition propose that our own actions influence our understanding of the world. Do other people's actions also have this influence? The present studies show that perceiving another person's actions changes the way people think about objects in a scene. In Study 1, participants viewed a photograph and answered a question…

  4. Conservation Action Handbook.

    ERIC Educational Resources Information Center

    National Rifle Association, Washington, DC.

    Conservation problems are identified, with some suggestions for action. General areas covered are: Wildlife Conservation, Soil Conservation, Clean Water, Air Pollution Action, and Outdoor Recreation Action. Appendices list private organizations or agencies concerned with natural resource use and/or management, congressional committees considering…

  5. Action in Development

    ERIC Educational Resources Information Center

    von Hofsten, Claes

    2007-01-01

    It is argued that cognitive development has to be understood in the functional perspective provided by actions. Actions reflect all aspects of cognitive development including the motives of the child, the problems to be solved, and the constraints and possibilities of the child's body and sensorimotor system. Actions are directed into the future…

  6. Planning as Action Research

    ERIC Educational Resources Information Center

    de Gonzalez, Carmen Beatriz; Hernandez, Teresa; Kusch, Jim; Ryan, Charly

    2004-01-01

    Planning contains so much more than the written plan. Early in 2000, an invitation came from the Collaborative Action Research Network (CARN), to people experienced in action research who might want to help plan and present an action research event for elementary school science teachers in Venezuela, South America, in Autumn 2000. This article…

  7. Participatory Action Research.

    ERIC Educational Resources Information Center

    Walker, Martha Lentz

    1993-01-01

    Describes aspects of participatory action research and considers advantages of using participatory action research in research by disabilities and rehabilitation researchers. Notes that participatory action research can be built into any rehabilitation research design but that it rests upon the recognition of persons with disabilities as integral…

  8. Understanding affirmative action.

    PubMed

    Crosby, Faye J; Iyer, Aarti; Sincharoen, Sirinda

    2006-01-01

    Affirmative action is a controversial and often poorly understood policy. It is also a policy that has been widely studied by social scientists. In this review, we outline how affirmative action operates in employment and education settings and consider the major points of controversy. In addition, we detail the contributions of psychologists and other social scientists in helping to demonstrate why affirmative action is needed; how it can have unintended negative consequences; and how affirmative action programs can be most successful. We also review how psychologists have examined variations in people's attitudes toward affirmative action, in part as a means for testing different theories of social behavior. PMID:16318608

  9. Lawrence Berkeley Laboratory Affirmative Action Program. Revised

    SciTech Connect

    1995-06-01

    The Lawrence Berkeley Laboratory`s Affirmative Action Program (AAP) serves as a working document that describes current policies, practices, and results in the area of affirmative action. It represents the Laboratory`s framework for an affirmative approach to increasing the representation of people of color and women in segments of our work force where they have been underrepresented and taking action to increase the employment of persons with disabilities and special disabled and Vietnam era veterans. The AAP describes the hierarchy of responsibility for Laboratory affirmative action, the mechanisms that exist for full Laboratory participation in the AAP, the policies and procedures governing recruitment at all levels, the Laboratory`s plan for monitoring, reporting, and evaluating affirmative action progress, and a description of special affirmative action programs and plans the Laboratory has used and will use in its efforts to increase the representation and retention of groups historically underrepresented in our work force.

  10. Habits as action sequences: hierarchical action control and changes in outcome value

    PubMed Central

    Dezfouli, Amir; Lingawi, Nura W.; Balleine, Bernard W.

    2014-01-01

    Goal-directed action involves making high-level choices that are implemented using previously acquired action sequences to attain desired goals. Such a hierarchical schema is necessary for goal-directed actions to be scalable to real-life situations, but results in decision-making that is less flexible than when action sequences are unfolded and the decision-maker deliberates step-by-step over the outcome of each individual action. In particular, from this perspective, the offline revaluation of any outcomes that fall within action sequence boundaries will be invisible to the high-level planner resulting in decisions that are insensitive to such changes. Here, within the context of a two-stage decision-making task, we demonstrate that this property can explain the emergence of habits. Next, we show how this hierarchical account explains the insensitivity of over-trained actions to changes in outcome value. Finally, we provide new data that show that, under extended extinction conditions, habitual behaviour can revert to goal-directed control, presumably as a consequence of decomposing action sequences into single actions. This hierarchical view suggests that the development of action sequences and the insensitivity of actions to changes in outcome value are essentially two sides of the same coin, explaining why these two aspects of automatic behaviour involve a shared neural structure. PMID:25267824

  11. Action adaptation during natural unfolding social scenes influences action recognition and inferences made about actor beliefs.

    PubMed

    Keefe, Bruce D; Wincenciak, Joanna; Jellema, Tjeerd; Ward, James W; Barraclough, Nick E

    2016-07-01

    When observing another individual's actions, we can both recognize their actions and infer their beliefs concerning the physical and social environment. The extent to which visual adaptation influences action recognition and conceptually later stages of processing involved in deriving the belief state of the actor remains unknown. To explore this we used virtual reality (life-size photorealistic actors presented in stereoscopic three dimensions) to see how visual adaptation influences the perception of individuals in naturally unfolding social scenes at increasingly higher levels of action understanding. We presented scenes in which one actor picked up boxes (of varying number and weight), after which a second actor picked up a single box. Adaptation to the first actor's behavior systematically changed perception of the second actor. Aftereffects increased with the duration of the first actor's behavior, declined exponentially over time, and were independent of view direction. Inferences about the second actor's expectation of box weight were also distorted by adaptation to the first actor. Distortions in action recognition and actor expectations did not, however, extend across different actions, indicating that adaptation is not acting at an action-independent abstract level but rather at an action-dependent level. We conclude that although adaptation influences more complex inferences about belief states of individuals, this is likely to be a result of adaptation at an earlier action recognition stage rather than adaptation operating at a higher, more abstract level in mentalizing or simulation systems. PMID:27472496

  12. Streamlined Approach for Environmental Restoration (SAFER) Plan for Corrective Action Unit 544: Cellars, Mud Pits, and Oil Spills, Nevada Test Site, Nevada, Revision 0

    SciTech Connect

    Mark Krauss

    2010-07-01

    recommendation for closure of the remaining CASs in CAU 544. This will be presented in a closure report (CR) that will be prepared and submitted to the Nevada Division of Environmental Protection (NDEP) for review and approval. The sites will be investigated based on the data quality objectives (DQOs) developed on April 27, 2010, by representatives of NDEP and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO). The DQO process was used to identify and define the type, amount, and quality of data needed to determine and implement appropriate corrective actions for each CAS in CAU 544. The DQO process developed for this CAU identified the following expected closure options: (1) investigation and confirmation that no contamination exists above the final action levels (FALs) leading to an NFA declaration, (2) characterization of the nature and extent of contamination leading to closure in place with use restrictions, (3) clean closure by remediation and verification, (4) closure in place with use restrictions with no investigation if CASs are in crater areas that have been determined to be unsafe to enter, or (5) NFA if the mud pit CAS meets the criteria established during the CAUs 530–535 SAFER investigation. The following summarizes the SAFER activities that will support the closure of CAU 544: • Perform visual inspection of all CASs. • Perform site preparation activities (e.g., utilities clearances, construction of temporary site exclusion zones). • Removal of easily managed, nonhazardous, and nonradioactive debris, including vegetation (e.g., tumbleweeds), at various CASs that interfere with sampling, if required to inspect soil surface or collect soil sample. • Collect environmental samples from designated target populations (e.g., mud pits, cellars, stained soil) to confirm or disprove the presence of contaminants of concern (COCs) as necessary to supplement existing information. • If no COCs are present at a

  13. Stereoscopically Observing Manipulative Actions

    PubMed Central

    Ferri, S.; Pauwels, K.; Rizzolatti, G.; Orban, G. A.

    2016-01-01

    The purpose of this study was to investigate the contribution of stereopsis to the processing of observed manipulative actions. To this end, we first combined the factors “stimulus type” (action, static control, and dynamic control), “stereopsis” (present, absent) and “viewpoint” (frontal, lateral) into a single design. Four sites in premotor, retro-insular (2) and parietal cortex operated specifically when actions were viewed stereoscopically and frontally. A second experiment clarified that the stereo-action-specific regions were driven by actions moving out of the frontoparallel plane, an effect amplified by frontal viewing in premotor cortex. Analysis of single voxels and their discriminatory power showed that the representation of action in the stereo-action-specific areas was more accurate when stereopsis was active. Further analyses showed that the 4 stereo-action-specific sites form a closed network converging onto the premotor node, which connects to parietal and occipitotemporal regions outside the network. Several of the specific sites are known to process vestibular signals, suggesting that the network combines observed actions in peripersonal space with gravitational signals. These findings have wider implications for the function of premotor cortex and the role of stereopsis in human behavior. PMID:27252350

  14. Stereoscopically Observing Manipulative Actions.

    PubMed

    Ferri, S; Pauwels, K; Rizzolatti, G; Orban, G A

    2016-08-01

    The purpose of this study was to investigate the contribution of stereopsis to the processing of observed manipulative actions. To this end, we first combined the factors "stimulus type" (action, static control, and dynamic control), "stereopsis" (present, absent) and "viewpoint" (frontal, lateral) into a single design. Four sites in premotor, retro-insular (2) and parietal cortex operated specifically when actions were viewed stereoscopically and frontally. A second experiment clarified that the stereo-action-specific regions were driven by actions moving out of the frontoparallel plane, an effect amplified by frontal viewing in premotor cortex. Analysis of single voxels and their discriminatory power showed that the representation of action in the stereo-action-specific areas was more accurate when stereopsis was active. Further analyses showed that the 4 stereo-action-specific sites form a closed network converging onto the premotor node, which connects to parietal and occipitotemporal regions outside the network. Several of the specific sites are known to process vestibular signals, suggesting that the network combines observed actions in peripersonal space with gravitational signals. These findings have wider implications for the function of premotor cortex and the role of stereopsis in human behavior. PMID:27252350

  15. Practicing What We Teach: Using Action Research to Learn about Teaching Action Research

    ERIC Educational Resources Information Center

    Brown, Barb; Dressler, Roswita; Eaton, Sarah Elaine; Jacobsen, Michele

    2015-01-01

    In this article, action research is explored as a process for instructor reflection, professional learning and collaboration. The context for the professional learning was the teaching of graduate level education courses in which action research, in conjunction with a cohort-based, collaboratory approach to learning, was used to facilitate…

  16. Action Learning in China

    ERIC Educational Resources Information Center

    Marquardt, Michael J.

    2015-01-01

    Action learning was introduced into China less than 20 years ago, but has rapidly become a valuable tool for organizations seeking to solve problems, develop their leaders, and become learning organizations. This article provides an historical overview of action learning in China, its cultural underpinnings, and five case studies. It concludes…

  17. Who Needs Affirmative Action.

    ERIC Educational Resources Information Center

    Ginger, Ann Fagan

    1979-01-01

    Affirmative action and reverse discrimination are discussed. Facts that were omitted from the court record on the Bakke case are examined. The need for encouraging minority students and women to continue to press for school admission and for lawyers to continue to press affirmative action suits is stressed. (MC)

  18. Affirmative Action in Israel.

    ERIC Educational Resources Information Center

    Lerner, Natan

    This paper examines issues of equality, discrimination, affirmative action, and preferential treatment in Israel. An introduction provides a broad outline of topics addressed in the paper: the status of the Jewish sector, with treatment of Jewish immigrants to serve as an example of affirmative action; the policies of the state in relation to the…

  19. Community-Action Learning

    ERIC Educational Resources Information Center

    Bell, Sarah; Mattern, Mark; Telin, Mike

    2007-01-01

    This paper describes and analyzes an undergraduate course entitled Public Interest Research in which students learn research methods by conducting research on behalf of one or more community organizations. Students' work is conceived of as community action learning, a combination of participatory action research and service learning, emphasizing…

  20. Social Action Art Therapy

    ERIC Educational Resources Information Center

    Golub, Deborah

    2005-01-01

    This paper explores intersections among art, action, and community. It describes sociopolitical aspects of the author's art therapy work with survivors of repressive regimes living in Brazil, China, and Denmark and considers ways that unique historical and social processes influenced her conceptualization and practice of social action art therapy.

  1. Training for Nonviolent Action.

    ERIC Educational Resources Information Center

    Olson, Theodore W.; Shivers, Lynne

    The theory and practice of nonviolent action training as it exists to date are reviewed in this pamphlet. A response to a renewal of interest in alternative forms of social action, the pamphlet results specifically from an international seminar of experienced organizers and trainers held at Preston Patrick, Westmorland, England, June 27 - July 2,…

  2. Renormalized action improvements

    SciTech Connect

    Zachos, C.

    1984-01-01

    Finite lattice spacing artifacts are suppressed on the renormalized actions. The renormalized action trajectories of SU(N) lattice gauge theories are considered from the standpoint of the Migdal-Kadanoff approximation. The minor renormalized trajectories which involve representations invariant under the center are discussed and quantified. 17 references.

  3. Action Research and Policy

    ERIC Educational Resources Information Center

    Foreman-Peck, Lorraine; Murray, Jane

    2008-01-01

    This article examines the relationship between action research and policy and the kind of confidence teachers, policy makers and other potential users may have in such research. Many published teacher action research accounts are criticised on the grounds that they do not fully meet the conventional standards for reporting social scientific…

  4. Affirmative Action Report, 1992.

    ERIC Educational Resources Information Center

    Nevada Univ. and Community Coll. System, Reno. Office of the Chancellor.

    All campuses and units of the University and Community College System of Nevada annually submit data to the Chancellor's Office on affirmative action. This report provides tables of affirmative action data for students enrolled during fall 1992 and professional and classified staff employed during 1992. First, student data is provided on gender…

  5. Handbook for Ecology Action.

    ERIC Educational Resources Information Center

    Eber, Ronald

    This handbook has been compiled to aid concerned individuals and ecology groups more adequately define their goals, initiate good programs, and take effective action. It examines the ways a group of working individuals can become involved in action programs for ecological change. Part 1 deals with organization, preliminary organizing, structuring,…

  6. ACTION. Annual Report 1974.

    ERIC Educational Resources Information Center

    ACTION, Washington, DC.

    In this report are described projects and activities undertaken by ACTION's volunteer programs in 1974. After an introduction that notes accomplishments of the past year, a review of domestic operations discusses such programs as VISTA, University Year for ACTION, National Student Volunteer Program, Foster Grandparent Program, and others according…

  7. Conscious Vision in Action.

    PubMed

    Briscoe, Robert; Schwenkler, John

    2015-09-01

    It is natural to assume that the fine-grained and highly accurate spatial information present in visual experience is often used to guide our bodily actions. Yet this assumption has been challenged by proponents of the Two Visual Systems Hypothesis (TVSH), according to which visuomotor programming is the responsibility of a "zombie" processing stream whose sources of bottom-up spatial information are entirely non-conscious (Clark, 2007, 2009; Goodale & Milner, 1992, 2004a; Milner & Goodale, 1995/2006, 2008). In many formulations of TVSH, the role of conscious vision in action is limited to "recognizing objects, selecting targets for action, and determining what kinds of action, broadly speaking, to perform" (Clark, 2007, p. 570). Our aim in this study is to show that the available evidence not only fails to support this dichotomous view but actually reveals a significant role for conscious vision in motor programming, especially for actions that require deliberate attention. PMID:25845648

  8. Following the Action in Action Learning: Towards Ethnomethodological Studies of (Critical) Action Learning

    ERIC Educational Resources Information Center

    Fox, Steve

    2009-01-01

    Action learning is a pedagogical practice that helps participants learn by talking about their workplace action with fellow participants ("comrades in adversity") in their action learning set. This paper raises questions about the action in action learning, such as: how do members of an action learning set learn from and through each other? How do…

  9. Hungarian climate change action plan

    SciTech Connect

    Molnar, S.; Takacs, T.; Arpasi, M.; Farago, T.; Palvoelgyi, T.; Harnos, Z.; Lontay, Z.; Somogyi, Z.; Tajthy, T.

    1998-12-31

    In 1994--1996, within the framework of the US Country Studies Program, the Hungarian Country Study Team developed the national greenhouse gas emission inventory, and elaborated the mitigation options for the different sectors of the economy. In 1997, the development of a National Action Plan was begun as the continuation of this work. Results of the inventory study showed that greenhouse gas emissions decreased from the selected base level (i.e., from the yearly average emissions of 1985--1987) until 1994 by cca. 25%. However, this decrease was primarily caused by the deep economic recession. Therefore the policy makers have to face the problem of economic recovery without a relevant increase of greenhouse gas emissions in the near future. This is the main focus of the mitigation analysis and the National Action Plan.

  10. Action spectra again?

    PubMed

    Coohill, T P

    1991-11-01

    Action spectroscopy has a long history and is of central importance to photobiological studies. Action spectra were among the first assays to point to chlorophyll as the molecule most responsible for plant growth and to DNA as the genetic material. It is useful to construct action spectra early in the investigation of new areas of photobiological research in an attempt to determine the wavelength limits of the radiation region causing the studied response. But due to the severe absorption of ultraviolet (UV) radiation by biological samples, UV action spectra were first limited to small cells (bacteria and fungi). Advances in techniques (e.g. single cell culture) and analysis allowed accurate action spectra to be reported even for mammalian cells. But precise analytical action spectra are often difficult to obtain when large, pigmented, or groups of cells are investigated. Here some action spectra are limited in interpretation and merely supply a wavelength vs effect curve. When polychromatic sources are employed, the interpretation of action spectra is even more complex and formidable. But such polychromatic action spectra can be more directly related to ambient responses. Since precise action spectra usually require the completion of a relatively large number of careful experiments using somewhat sophisticated equipment over a range of at least six wavelengths, they are often not pursued. But they remain central to the elucidation of the effect being studied. The worldwide community has agreed that stratospheric ozone is depleting, with the possibility of a consequent rise in the amount of UV-B (290-320 nm) reaching the earth's surface. It is therefore essential that new action spectra be completed for UV-B effects on a large variety of responses of human, animal, and aquatic plant systems. Combining these action spectra with the known amounts of UV-B reaching the biosphere can give rise to solar UV effectiveness spectra that, in turn, can give rise to estimates

  11. Conceptualizing Indicator Domains for Evaluating Action Research

    ERIC Educational Resources Information Center

    Piggot-Irvine, Eileen; Rowe, Wendy; Ferkins, Lesley

    2015-01-01

    The focus of this paper is to share thinking about meta-level evaluation of action research (AR), and to introduce indicator domains for assessing and measuring inputs, outputs and outcomes. Meta-level and multi-site evaluation has been rare in AR beyond project implementation and participant satisfaction. The paper is the first of several…

  12. Planning actions in robot automated operations

    NASA Technical Reports Server (NTRS)

    Das, A.

    1988-01-01

    Action planning in robot automated operations requires intelligent task level programming. Invoking intelligence necessiates a typical blackboard based architecture, where, a plan is a vector between the start frame and the goal frame. This vector is composed of partially ordered bases. A partial ordering of bases presents good and bad sides in action planning. Partial ordering demands the use of a temporal data base management system.

  13. Conscious Control over Action

    PubMed Central

    Shepherd, Joshua

    2015-01-01

    The extensive involvement of nonconscious processes in human behaviour has led some to suggest that consciousness is much less important for the control of action than we might think. In this article I push against this trend, developing an understanding of conscious control that is sensitive to our best models of overt (that is, bodily) action control. Further, I assess the cogency of various zombie challenges—challenges that seek to demote the importance of conscious control for human agency. I argue that though nonconscious contributions to action control are evidently robust, these challenges are overblown. PMID:26113753

  14. Corrective Action Glossary

    SciTech Connect

    Not Available

    1992-07-01

    The glossary of technical terms was prepared to facilitate the use of the Corrective Action Plan (CAP) issued by OSWER on November 14, 1986. The CAP presents model scopes of work for all phases of a corrective action program, including the RCRA Facility Investigation (RFI), Corrective Measures Study (CMS), Corrective Measures Implementation (CMI), and interim measures. The Corrective Action Glossary includes brief definitions of the technical terms used in the CAP and explains how they are used. In addition, expected ranges (where applicable) are provided. Parameters or terms not discussed in the CAP, but commonly associated with site investigations or remediations are also included.

  15. Toxic action/toxicity.

    PubMed

    Hathway, D E

    2000-02-01

    ,Z-muconaldehyde forms cyclic products containing a pyrrole residue linked to purine. Increased HbCO concentrations reduce the O2-carrying capacity of the blood, and the changed shape of the O2-Hb dissociation curve parallels disturbance in O2 unloading. CN- acts on electron transport and paralyses respiration. In telodrin poisoning, preconvulsive glutamine formation abstracts tricarboxylic acid intermediates incommensurately with normal cerebral respiration. Antigen-antibody complexing depletes the antibody titre, available against infection. At high doses of Cd, Cd-thionein filtered through the kidneys is reabsorbed and tubular lesions produced. Some organophosphate insecticides promote irreversible acetylcholinesterase phosphorylation and blockade nerve function, and others react with neurotoxic esterase to cause delayed neuropathy. The evidence for Paraquat pulmonary poisoning suggests a radical mechanism involving three interrelated cyclic reaction stages. The action of N- and O8 (O substituent in 6-position of the purine) demethylases explains deletion mechanisms for DNA-alkyl adducts. DNA-directed synthesis in the presence of ultimate carcinogens provides for an estimation of misincorporations, which implicate the same transversions as those found by direct mutagenicity testing. Chemical carcinogens recognize tissue-sensitive cells and modify their heritable genetic complement. Oncoproteins encoded by activated oncogenes signal the transformation of normal cells into cancer cells. The importance of the H-ras oncogene and p53 tumour-suppressor gene is stressed. Antidotal action is analysed; for example, parenteral glutamine administration to telodrin-intoxicated rats restores the depleted cerebral glutamate level and prevents seizures. Glutamate acts as anticonvulsant in petit mal epilepsy. In general, therefore, the reaction of the toxicant-related substance with the relevant target-tissue macromolecule accounts for the biochemical/biological events at a cellular level a PMID

  16. Immunization Action Coalition

    MedlinePlus

    ... IAC | Contact | A-Z Index | Donate | Shop | SUBSCRIBE Immunization Action Coalition Handouts for Patients & Staff A-Z ... Index Supplies Checklist Administering Vaccines Temperature Logs Adult Vaccination Topics of Interest Documenting Vaccination Translations Parent Handouts ...

  17. Caregiver Action Network

    MedlinePlus

    ... main content Caregiver Action Network Toggle navigation Toolbox Forum Volunteers Donate About Us Join National Family Caregivers ... for caring for a loved one Family Caregiver Forum Share and talk with other caregivers Rare Disease ...

  18. Postpartum Depression Action Plan

    MedlinePlus

    MENU Return to Web version Postpartum Depression | Postpartum Depression Action Plan Patient __________________________ Physician/NP/PA __________________ Clinic ____________________________ Phone Number ____________________ Choose one area and add other areas as you begin to ...

  19. Affirmative Action's Contradictory Consequences.

    ERIC Educational Resources Information Center

    Heilman, Madeline E.

    1996-01-01

    Addresses affirmative action's success at creating a more equal workplace. Explores some potential psychological costs of this policy--costs that paradoxically may undermine its objectives--and their implications for achieving the goal of workplace equality. (GR)

  20. Commitment to action. Population Action International.

    PubMed

    Squires, S

    1994-01-01

    The national chair of Population Action International (formerly the Population Crisis Committee), Robin Chandler Duke, is a crusader for women's reproductive rights. She was in Bangladesh in 1971 during its civil war. Soldiers would rape young Muslim women, and their families would reject them when they became pregnant. The head of the exiled government agreed to let physicians from IPPF perform abortions on these women, which allowed families to take them back. Opposition to the abortions arose, however. This experience in Bangladesh sparked Ms. Duke's interest in population control. Her years as the wife of a US diplomat granted her access to powerful people worldwide. Her predecessor, retired US Army General Bill Draper, called Ms. Duke from his death bed in 1974 to ask her to be national chair of PAI. She served as a delegate in various international meetings, e.g., the 1980 UNESCO meetings in Belgrade. Spain and Luxembourg honored her for her work of campaigning for women's reproductive rights. She believes that rapid population growth is the most significant problem in the world today. It exacerbates poverty, environmental destruction, and political instability. She believes that universal availability of high quality, voluntary family planning services, including safe abortion, is needed to save humanity from the vicious cycle. Since family planning, sex education, and abortion are the most personal and sensitive parts of people's lives, Population Action frames family planning in the context of basic health care. AIDS complicates the issue, because contraception is no longer limited to birth control. Even though the organization realizes that sexual abstinence is the best way to avoid AIDS, it tries to educate female teenagers not to let boys coerce them to have sex. If they do, have sex Population Action advocates condom use. Ms. Duke cites the family planning successes of Indonesia, Zimbabwe, and Thailand. PMID:12319083

  1. Galileons from Lovelock actions

    SciTech Connect

    Van Acoleyen, Karel; Van Doorsselaere, Jos

    2011-04-15

    We demonstrate how, for an arbitrary number of dimensions, the Galileon actions and their covariant generalizations can be obtained through a standard Kaluza-Klein compactification of higher-dimensional Lovelock gravity. In this setup, the dilaton takes on the role of the Galileon. In addition, such compactifications uncover other more general Galilean actions, producing purely second-order equations in the weak-field limit, now both for the Galileon and the metric perturbations.

  2. Action Learning as Invigoration

    ERIC Educational Resources Information Center

    Chivers, Terence S.

    2011-01-01

    The present account of action learning describes its adoption for pragmatic reasons by the University of the Third Age (U3A). The reason for the existence of this movement is the education of retired people. The account seeks to explain why the action learning method spread from one local U3A to another and across it to other local U3As. The case…

  3. Cardiac action potential imaging

    NASA Astrophysics Data System (ADS)

    Tian, Qinghai; Lipp, Peter; Kaestner, Lars

    2013-06-01

    Action potentials in cardiac myocytes have durations in the order of magnitude of 100 milliseconds. In biomedical investigations the documentation of the occurrence of action potentials is often not sufficient, but a recording of the shape of an action potential allows a functional estimation of several molecular players. Therefore a temporal resolution of around 500 images per second is compulsory. In the past such measurements have been performed with photometric approaches limiting the measurement to one cell at a time. In contrast, imaging allows reading out several cells at a time with additional spatial information. Recent developments in camera technologies allow the acquisition with the required speed and sensitivity. We performed action potential imaging on isolated adult cardiomyocytes of guinea pigs utilizing the fluorescent membrane potential sensor di-8-ANEPPS and latest electron-multiplication CCD as well as scientific CMOS cameras of several manufacturers. Furthermore, we characterized the signal to noise ratio of action potential signals of varying sets of cameras, dye concentrations and objective lenses. We ensured that di-8-ANEPPS itself did not alter action potentials by avoiding concentrations above 5 μM. Based on these results we can conclude that imaging is a reliable method to read out action potentials. Compared to conventional current-clamp experiments, this optical approach allows a much higher throughput and due to its contact free concept leaving the cell to a much higher degree undisturbed. Action potential imaging based on isolated adult cardiomyocytes can be utilized in pharmacological cardiac safety screens bearing numerous advantages over approaches based on heterologous expression of hERG channels in cell lines.

  4. [Addictions and action systems].

    PubMed

    Loonis, E; Apter, M J

    2000-01-01

    Generalizing from some previous analyses of addiction, and introducing the concept of an action system which governs all actions which are focussed on what Brown (1988) calls "hedonic management", we argue that addictions of every kind involve an action system that displays high salience, low variety and low vicariance. Addictions also involve what Apter (1982) calls the "paratelic state". A study was carried out comparing 31 drug addicts with 29 control subjects in terms of action system variables. To measure these variables, we constructed a new instrument, the Activity-System Drawing Test, and also used the Telic Dominance Scale to measure frequency of paratelic states. Dysphoria was measured by means of the BATE (anxiety), IDA-13 (depression), SEI (self-esteem), and TAS-20 (alexithymia) instruments. Strongly significant differences were found between groups for both action system variables and dysphoria, and there were also strong correlations between both groups of variables. This supports the idea that addictions emerge from systemic properties of the action system. PMID:10858918

  5. Laser action by optically depumping lower states

    DOEpatents

    Krupke, William F.

    1977-01-01

    A method and apparatus for obtaining laser action between an upper energy level and a lower energy level of a gaseous medium, which comprises populating the upper energy level to some degree (short of achieving a conventional inverted population) by any suitable pumping means, and thereafter establishing an inverted population by transiently and selectively depumping the lower energy level such as by exposing the medium to an intense source of radiation which selectively causes the transformation of the lower energy level species to some other energy level. Thus, a thermally pumped/optically depumped gas laser system is produced.

  6. Laser action by optically depumping lower states

    DOEpatents

    Krupke, W.F.

    1975-11-26

    A method and apparatus are described for obtaining laser action between an upper energy level and a lower energy level of a gaseous medium. The upper energy level is populated to some degree (short of achieving a conventional inverted population) by any suitable pumping means, and an inverted population is established by transiently and selectively depumping the lower energy level. The depumping may be done by exposing the medium to an intense source of radiation which selectively causes the transformation of the lower energy level species to some other energy level. Thus, a thermally pumped/optically depumped gas laser system is produced.

  7. Errata Sheet for the Corrective Action Plan for Corrective Action Unit 166: Storage Yards and Contaminated Materials, Nevada Test Site, Nevada

    SciTech Connect

    NSTec Environmental Restoration

    2007-12-21

    On Page 6, in Section 2.1.1.4, fourth paragraph, third sentence, ''FAL'' should be ''PAL''. The sentence should read, ''TPH was also present at concentrations above the PAL in all three wax samples that were analyzed for TPH''.

  8. [Biological actions of acetaldehyde].

    PubMed

    Ijiri, I

    1999-11-01

    Acetaldehyde (AcH), the first metabolite of ethanol (EtOH), is a chemically reactive and pharmacologically active compound. The author has been engaged in the study of AcH in cooperation with many researchers for three decades. We have found many biological actions of AcH which cause cardiovascular symptoms after drinking and also inhibited EtOH absorption via the canine and rat intestinal tract. This report covers the following five points. 1. The subjects were classified into a non-flushing group and a flushing group, according to the degree of facial flushing after drinking 200 ml of Sake (Japanese rice wire) at a rate of 100 ml per 5 min. Blood EtOH profile was much the same in both groups, yet peak blood AcH concentration in the flushing group was significantly higher than that in the non-flushing group. All subjects in the flushing group showed marked flushing and an increase in pulse rate after drinking, but these symptoms were not apparent in the non-flushing group. These results suggested that cardiovascular symptoms were caused by AcH itself. 2. Urinary excretions of both norepinephrine and epinephrine increased in the flushing cases after drinking Sake in comparison with those who drank the same volume of water. However, these catecholamines did not change in the non-flushing group. These results suggested that it is catecholamines released from the sympathetic nerve end or the adrenal medulla by AcH which caused an increase in pulse rate. 3. Bradykinin is released from high molecular kininogen by activated kallikrein and acts to dilate distal blood vessels and raise permeability in tissues. On the other hand, kallidin is released from low molecular kininogen by activated glandular kallikrein and its action is weaker than that of bradykinin. Blood low molecular kininogen levels in the flushing group decreased gradually after drinking and were mutually related to the blood AcH concentrations. But levels in the non-flushing group showed no difference

  9. Corrective Action Decision Document for Corrective Action Unit 204: Storage Bunkers, Nevada Test Site, Nevada, Rev. No. 0

    SciTech Connect

    Robert Boehlecke

    2004-04-01

    The six bunkers included in CAU 204 were primarily used to monitor atmospheric testing or store munitions. The ''Corrective Action Investigation Plan (CAIP) for Corrective Action Unit 204: Storage Bunkers, Nevada Test Site, Nevada'' (NNSA/NV, 2002a) provides information relating to the history, planning, and scope of the investigation; therefore, it will not be repeated in this CADD. This CADD identifies potential corrective action alternatives and provides a rationale for the selection of a recommended corrective action alternative for each CAS within CAU 204. The evaluation of corrective action alternatives is based on process knowledge and the results of investigative activities conducted in accordance with the CAIP (NNSA/NV, 2002a) that was approved prior to the start of the Corrective Action Investigation (CAI). Record of Technical Change (ROTC) No. 1 to the CAIP (approval pending) documents changes to the preliminary action levels (PALs) agreed to by the Nevada Division of Environmental Protection (NDEP) and DOE, National Nuclear Security Administration Nevada Site Office (NNSA/NSO). This ROTC specifically discusses the radiological PALs and their application to the findings of the CAU 204 corrective action investigation. The scope of this CADD consists of the following: (1) Develop corrective action objectives; (2) Identify corrective action alternative screening criteria; (3) Develop corrective action alternatives; (4) Perform detailed and comparative evaluations of corrective action alternatives in relation to corrective action objectives and screening criteria; and (5) Recommend and justify a preferred corrective action alternative for each CAS within CAU 204.

  10. New lattice action for heavy quarks

    SciTech Connect

    Oktay, Mehmet B.; Kronfeld, Andreas S.

    2008-03-01

    We extend the Fermilab method for heavy quarks to include interactions of dimension six and seven in the action. There are, in general, many new interactions, but we carry out the calculations needed to match the lattice action to continuum QCD at the tree level, finding six non-zero couplings. Using the heavy-quark theory of cutoff effects, we estimate how large the remaining discretization errors are. We find that our tree-level matching, augmented with one-loop matching of the dimension-five interactions, can bring these errors below 1%, at currently available lattice spacings.

  11. Action recognition in the visual periphery.

    PubMed

    Fademrecht, Laura; Bülthoff, Isabelle; de la Rosa, Stephan

    2016-01-01

    Recognizing whether the gestures of somebody mean a greeting or a threat is crucial for social interactions. In real life, action recognition occurs over the entire visual field. In contrast, much of the previous research on action recognition has primarily focused on central vision. Here our goal is to examine what can be perceived about an action outside of foveal vision. Specifically, we probed the valence as well as first level and second level recognition of social actions (handshake, hugging, waving, punching, slapping, and kicking) at 0° (fovea/fixation), 15°, 30°, 45°, and 60° of eccentricity with dynamic (Experiment 1) and dynamic and static (Experiment 2) actions. To assess peripheral vision under conditions of good ecological validity, these actions were carried out by a life-size human stick figure on a large screen. In both experiments, recognition performance was surprisingly high (more than 66% correct) up to 30° of eccentricity for all recognition tasks and followed a nonlinear decline with increasing eccentricities. PMID:26913625

  12. Classifying Facial Actions

    PubMed Central

    Donato, Gianluca; Bartlett, Marian Stewart; Hager, Joseph C.; Ekman, Paul; Sejnowski, Terrence J.

    2010-01-01

    The Facial Action Coding System (FACS) [23] is an objective method for quantifying facial movement in terms of component actions. This system is widely used in behavioral investigations of emotion, cognitive processes, and social interaction. The coding is presently performed by highly trained human experts. This paper explores and compares techniques for automatically recognizing facial actions in sequences of images. These techniques include analysis of facial motion through estimation of optical flow; holistic spatial analysis, such as principal component analysis, independent component analysis, local feature analysis, and linear discriminant analysis; and methods based on the outputs of local filters, such as Gabor wavelet representations and local principal components. Performance of these systems is compared to naive and expert human subjects. Best performances were obtained using the Gabor wavelet representation and the independent component representation, both of which achieved 96 percent accuracy for classifying 12 facial actions of the upper and lower face. The results provide converging evidence for the importance of using local filters, high spatial frequencies, and statistical independence for classifying facial actions. PMID:21188284

  13. ES H action plan

    SciTech Connect

    Not Available

    1991-01-01

    This document contains planned actions to correct the deficiencies identified in the Pre-Tiger Team Self-Assessment (PTTSA), January 1991, of Sandia National Laboratories (SNL -- Albuquerque, New Mexico; Tonopah, Nevada; and Kauai, Hawaii). The Self-Assessment was conducted by a Self-Assessment Working Group consisting of 19 department managers, with support from Environment, Safety, and Health (ES H) professionals, from October through December 1990. Findings from other past audits, dating back to 1985, were reviewed and compared with the PTTSA findings to determine if additional findings, key findings, or root causes were warranted. The resulting ES H Action Plan and individual planned actions were prepared by the ES H Action Plan Project Group with assistance from the Program owners/authors during February and March 1991. The plan was reviewed by SNL Management in April 1991. This document serves as a planning instrument for the Laboratories to aid in the scoping and sizing of activities related to ES H compliance for the coming five years. It will be modified as required to ensure a workload/funding balance and to address the findings resulting from the Tiger Team assessment at SNL, Albuquerque. The process of producing this document has served well to prepare SNL, Albuquerque, for the coming task of producing the required post-Tiger Team action plan document. 8 tabs.

  14. Effects of Security actions

    NASA Astrophysics Data System (ADS)

    Bergman, Ramona; Andersson-Sköld, Yvonne; Nyberg, Lars; Johansson, Magnus

    2010-05-01

    In a project funded by the Swedish Civil Contingencies Agency, the effort and work to reduce different kinds of accidents are being evaluated. The project wants to illuminate the links between actions and outcome, so we can learn from today's performance and in the future select more effective measures and overall deal with accidents more efficiently. The project ESS covers the field of frequent accidents such as sliding accidents at home, in house fires and less common accidents such as chemical and land fill accidents up to even more rare accidents such as natural accidents and hazards. In the ESS project SGI (Swedish geotechnical institute) will evaluate the work and effort concerning various natural hazards limited to landslides, erosion and flooding. The aim is to investigate how municipalities handle, especially prevention, of such natural disasters today. The project includes several aspects such as: • which are the driving forces for risk analysis in a municipality • do one use risk mapping (and what type) in municipal risk analysis • which aspects are most important when selecting preventive measures • in which way do one learn from past accidents • and from previous accidents elsewhere, by for example use existing databases • etc There are many aspects that play a role in a well-functioning safety promotion work. The overall goal is to examine present work and activities, highlight what is well functioning and identify weak points. The aim is to find out where more resources are needed and give suggestions for a more efficient security work. This includes identification of the most efficient "tools" in use or needed. Such tools can be education, directives, funding, more easily available maps and information regarding previous accidents and preventive measures etc. The project will result in recommendations for more effective ways to deal with landslides, erosion and flooding. Since different kinds of problems can occur depending on level of

  15. Mitigation Action Plan

    SciTech Connect

    Not Available

    1994-02-01

    This Mitigation Action Plan (MAP) focuses on mitigation commitments stated in the Supplemental Environmental Impact Statement (SEIS) and the Record of Decision (ROD) for the Naval Petroleum Reserve No. 1 (NPR-1). Specific commitments and mitigation implementation actions are listed in Appendix A-Mitigation Actions, and form the central focus of this MAP. They will be updated as needed to allow for organizational, regulatory, or policy changes. It is the intent of DOE to comply with all applicable federal, state, and local environmental, safety, and health laws and regulations. Eighty-six specific commitments were identified in the SEIS and associated ROD which pertain to continued operation of NPR-1 with petroleum production at the Maximum Efficient Rate (MER). The mitigation measures proposed are expected to reduce impacts as much as feasible, however, as experience is gained in actual implementation of these measures, some changes may be warranted.

  16. Action languages: Dimensions, effects

    NASA Technical Reports Server (NTRS)

    Hayes, Daniel G.; Streeter, Gordon

    1989-01-01

    Dimensions of action languages are discussed for communication between humans and machines, and the message handling capabilities of object oriented programming systems are examined. Design of action languages is seen to be very contextual. Economical and effective design will depend on features of situations, the tasks intended to be accomplished, and the nature of the devices themselves. Current object oriented systems turn out to have fairly simple and straightforward message handling facilities, which in themselves do little to buffer action or even in some cases to handle competing messages. Even so, it is possible to program a certain amount of discretion about how they react to messages. Such thoughtfulness and perhaps relative autonomy of program modules seems prerequisite to future systems to handle complex interactions in changing situations.

  17. Learning to take actions

    SciTech Connect

    Khardon, R.

    1996-12-31

    We formalize a model for supervised learning of action strategies in dynamic stochastic domains, and show that pac-learning results on Occam algorithms hold in this model as well. We then identify a particularly useful bias for action strategies based on production rule systems. We show that a subset of production rule systems, including rules in predicate calculus style, small hidden state, and unobserved support predicates, is properly learnable. The bias we introduce enables the learning algorithm to invent the recursive support predicates which are used in the action strategy, and to reconstruct the internal state of the strategy. It is also shown that hierarchical strategies are learnable if a helpful teacher is available, but that otherwise the problem is computationally hard.

  18. Action of methyl-, propyl- and butylparaben on GPR30 gene and protein expression, cAMP levels and activation of ERK1/2 and PI3K/Akt signaling pathways in MCF-7 breast cancer cells and MCF-10A non-transformed breast epithelial cells.

    PubMed

    Wróbel, Anna Maria; Gregoraszczuk, Ewa Łucja

    2015-10-14

    In the present study, we examined cAMP levels and activation of the MAPK/ERK1/2 and PI3K/Akt signaling pathways in response to the actions of parabens on GPR30 in MCF-7 and MCF-10A cells. Cells were exposed to methyl-, propyl- or butylparaben at a concentration of 20nM; 17-β-estradiol (10nM) was used as a positive control. 17β-estradiol and all tested parabens increased GPR30 gene and protein expression in MCF-7 and MCF-10A cells. No parabens affected cAMP levels in either cell line, with the exception of propylparaben in MCF-10A cells. 17β-estradiol, propylparaben, and butylparaben increased phosphorylation of ERK1/2 in MCF-7 cells, whereas 17β-estradiol, methyl- and butylparaben, but not propylparaben, increased phosphorylation of ERK1/2 in MCF-10A cells. Akt activation was noted only in MCF-7 cells and only with propylparaben treatment. Collectively, the data presented here point to a nongenomic mechanism of action of parabens in activation GPR30 in both cancer and non-cancer breast cell lines through βγ dimer-mediated activation of the ERK1/2 pathway, but not the cAMP/PKA pathway. Moreover, among investigated parabens, propylparaben appears to inhibit apoptosis in cancer cells through activation of Akt kinases, confirming conclusions suggested by our previously published data. Nevertheless, continuing research on the carcinogenic action of parabens is warranted. PMID:26253279

  19. Improving Learning and Teaching through Action Learning and Action Research.

    ERIC Educational Resources Information Center

    Zuber-Skeriit, Ortrun

    1993-01-01

    A theoretical framework for action learning and action research is presented, as a basis for better understanding college instruction and learning. Action research is viewed as a philosophy, theory of learning, research methodology, and teaching technique. It is argued that action research both increases knowledge and improves teaching.…

  20. Rise in DPA Following SDA-Rich Dietary Echium Oil Less Effective in Affording Anti-Arrhythmic Actions Compared to High DHA Levels Achieved with Fish Oil in Sprague-Dawley Rats

    PubMed Central

    Abeywardena, Mahinda Y.; Adams, Michael; Dallimore, Julie; Kitessa, Soressa M.

    2016-01-01

    Stearidonic acid (SDA; C18:4n-3) has been suggested as an alternative to fish oil (FO) for delivering health benefits of C ≥ 20 long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA). Echium oil (EO) represents a non-genetically-modified source of SDA available commercially. This study compared EO and FO in relation to alterations in plasma and tissue fatty acids, and for their ability to afford protection against ischemia-induced cardiac arrhythmia and ventricular fibrillation (VF). Rats were fed (12 weeks) diets supplemented with either EO or FO at three dose levels (1, 3 and 5% w/w; n = 18 per group). EO failed to influence C22:6n-3 (DHA) but increased C22:5n-3 (DPA) in tissues dose-dependently, especially in heart tissue. Conversely, DHA in hearts of FO rats showed dose-related elevation; 14.8%–24.1% of total fatty acids. Kidney showed resistance for incorporation of LC n-3 PUFA. Overall, FO provided greater cardioprotection than EO. At the highest dose level, FO rats displayed lower (p < 0.05) episodes of VF% (29% vs. 73%) and duration (22.7 ± 12.0 vs. 75.8 ± 17.1 s) than the EO group but at 3% EO was comparable to FO. We conclude that there is no endogenous conversion of SDA to DHA, and that DPA may be associated with limited cardiac benefit. PMID:26742064

  1. Contradictory effects of chlorpromazine on endothelial cells in a rat model of endotoxic shock in association with its actions on serum TNF-alpha levels and antioxidant enzyme activities.

    PubMed

    Can, Cenk; Demirci, Buket; Uysal, Ayşegül; Akçay, Yasemin Delen; Koşay, Sezen

    2003-09-01

    We examined the effects of the phenothiazine derivative, chlorpromazine on thoracic aortic endothelial cell histology (14 h after LPS challenge) in a model of endotoxic shock in rats. Since excessive formation of tumor necrosis factor-alpha (TNF-alpha) and oxygen-derived free radicals contribute to endothelial injury in endotoxemia, we also evaluated the effect of the drug on the activities of antioxidant enzymes superoxide dismutase (SOD) and catalase in liver tissue in this model and tried to find out whether this possible effect was associated with a change in serum TNF-alpha levels (measured 90 min after chlorpromazine administration). Endotoxemia was induced by a single i.p. injection of lipopolysaccharide (LPS) (5 mg kg(-1) in 1.5 ml of saline; LPS from Escherichia coli serotype 055:B5, L-2880, Sigma Chemical Company). Electron microscopic evaluation of the aortas revealed that chlorpromazine (administered 30 min prior to LPS challenge), in smaller doses (3 mg kg(-1)) ameliorated the endothelial cell injury caused by LPS, whereas it caused deterioration of endothelial cell morphology in higher doses (10 and 25 mg kg(-1)). Chlorpromazine administration caused a significant reduction in serum TNF-alpha levels, which was correlated well with an increase in SOD activity in all drug doses (3, 10 and 25 mg kg(-1)). Catalase activity was increased only in the 25 mg kg(-1) chlorpromazine group. PMID:12860438

  2. Rise in DPA Following SDA-Rich Dietary Echium Oil Less Effective in Affording Anti-Arrhythmic Actions Compared to High DHA Levels Achieved with Fish Oil in Sprague-Dawley Rats.

    PubMed

    Abeywardena, Mahinda Y; Adams, Michael; Dallimore, Julie; Kitessa, Soressa M

    2016-01-01

    Stearidonic acid (SDA; C18:4n-3) has been suggested as an alternative to fish oil (FO) for delivering health benefits of C ≥ 20 long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA). Echium oil (EO) represents a non-genetically-modified source of SDA available commercially. This study compared EO and FO in relation to alterations in plasma and tissue fatty acids, and for their ability to afford protection against ischemia-induced cardiac arrhythmia and ventricular fibrillation (VF). Rats were fed (12 weeks) diets supplemented with either EO or FO at three dose levels (1, 3 and 5% w/w; n = 18 per group). EO failed to influence C22:6n-3 (DHA) but increased C22:5n-3 (DPA) in tissues dose-dependently, especially in heart tissue. Conversely, DHA in hearts of FO rats showed dose-related elevation; 14.8%-24.1% of total fatty acids. Kidney showed resistance for incorporation of LC n-3 PUFA. Overall, FO provided greater cardioprotection than EO. At the highest dose level, FO rats displayed lower (p < 0.05) episodes of VF% (29% vs. 73%) and duration (22.7 ± 12.0 vs. 75.8 ± 17.1 s) than the EO group but at 3% EO was comparable to FO. We conclude that there is no endogenous conversion of SDA to DHA, and that DPA may be associated with limited cardiac benefit. PMID:26742064

  3. Jump into Action

    ERIC Educational Resources Information Center

    Ball, Stephen; Cohen, Ann; Meyer, Margaret

    2012-01-01

    Jump Into Action (JIA) is a school-based team-taught program to help fifth-grade students make healthy food choices and be more active. The JIA team (physical education teacher, classroom teacher, school nurse, and parent) work together to provide a supportive environment as students set goals to improve food choices and increase activity.…

  4. Conclusions and Federal actions

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Findings regarding fluorocarbon production, the roles of ozone and fluorocarbons in atmospheric chemistry, the depletion of stratospheric ozone by fluorocarbons, and various effects of this depletion are outlined. Research into these areas is described and recommendations are given for governmental action to reduce the release of fluorocarbons to the environment.

  5. The Constitution in Action

    ERIC Educational Resources Information Center

    Potter, Lee Ann

    2007-01-01

    In this article, the author describes the experiences middle school students on a field trip to the new Constitution in Action Learning Lab in the Boeing Learning Center at the National Archives can expect. There, middle school students take on the roles of archivists and researchers collecting and analyzing primary sources from the holdings of…

  6. Affirmative Action Plan.

    ERIC Educational Resources Information Center

    Triton Coll., River Grove, IL.

    In order to develop an affirmative action plan at Triton College, the college President appointed a committee made up of nine representatives from the various college constituencies, the majority of which were women and minorities, to determine the objectives to be achieved and how to implement them, and to establish appropriate review procedures.…

  7. Justifying Action Research

    ERIC Educational Resources Information Center

    Helskog, Guro Hansen

    2014-01-01

    In this paper I use a general philosophy of science perspective in looking at the problem of justifying action research. First I try to clarify the concept of justification, by contrasting it with the concept of validity, which seems to be used almost as a synonym in some parts of the literature. I discuss the need for taking a stand in relation…

  8. Hope for Environmental Action

    ERIC Educational Resources Information Center

    Fleischer, Barbara J.; DeMoor, Emily

    2015-01-01

    Environmental consciousness-raising programs tend to emphasize the magnitude of imminent ecological disasters, if humans continue on their current trajectory. While these environmental literacy programs also call for action to avoid cataclysmic ecological changes, psychological research on "learned helplessness" suggests that information…

  9. Community Action Curriculum Compendium.

    ERIC Educational Resources Information Center

    Duncan, Karen

    This compendium contains descriptions of 59 community action projects that receive academic credit from 48 colleges and universities. Brief descriptions are given of the diverse institutions offering such field work for credit, including information on enrollment and type (i.e., public, private, etc.). Although the characteristics of the programs…

  10. School Reform in Action.

    ERIC Educational Resources Information Center

    Miller, A. Christine

    This study describes and analyzes the impact on student learning and the learning environment of 55 schools in Broward, Palm Beach, and Miami-Dade school districts as they implemented the schoolwide action-research framework for school improvement. Interviews, observations, document review during site visits, school framework reports, surveys,…

  11. Action Learning Issues.

    ERIC Educational Resources Information Center

    1998

    This document contains four papers from a symposium on adult learning issues and human resource development (HRD). "Creating a Systemic Framework for the Transfer of Learning from an Action Learning Experience" (Suzanne D. Butterfield, Kitty Gold, Verna J. Willis) discusses a study of the organizational elements that affect learning and transfer…

  12. Early Childhood Action Tips.

    ERIC Educational Resources Information Center

    O'Donnell, Nina Sazer

    In response to requests for information from people and organizations all over the United States on how to contribute to the healthy development of young children, the Families and Work Institute has gathered concrete suggestions from leaders in diverse fields into this booklet of action tips. This effort was undertaken to support the "I Am Your…

  13. Quick action clamp

    NASA Technical Reports Server (NTRS)

    Calco, Frank S. (Inventor)

    1991-01-01

    A quick release toggle clamp that utilizes a spring that requires a deliberate positive action for disengagement is presented. The clamp has a sliding bolt that provides a latching mechanism. The bolt is moved by a handle that tends to remain in an engaged position while under tension.

  14. From Awareness to Action

    ERIC Educational Resources Information Center

    Micklos, John, Jr.

    2012-01-01

    What inspires young people to become activists? Events such as wars or regime changes obviously raise high emotions. But some choose to get involved because they saw a need and felt compelled to take action. Young Americans have a long track record as activists. Among other things, they played a key role in the civil rights movement of the 1950s…

  15. ACTION. Annual Report 1978.

    ERIC Educational Resources Information Center

    ACTION, Washington, DC.

    In this report are described projects and activities undertaken by ACTION's volunteer programs in 1978. The introduction notes a continued growth in programs and comments on new developments. Older American Volunteer Programs are discussed in the next section, specifically the Retired Senior Volunteer Program, Foster Grandparent Program, and…

  16. The Shape of Action

    ERIC Educational Resources Information Center

    Hard, Bridgette Martin; Recchia, Gabriel; Tversky, Barbara

    2011-01-01

    How do people understand the everyday, yet intricate, behaviors that unfold around them? In the present research, we explored this by presenting viewers with self-paced slideshows of everyday activities and recording looking times, subjective segmentation (breakpoints) into action units, and slide-to-slide physical change. A detailed comparison of…

  17. Affirmative Action for Men?

    ERIC Educational Resources Information Center

    Malveaux, Julianne

    2005-01-01

    If colleges are willing to consider "social engineering" and affirmative action to ensure the inclusion of White men, are they willing to do so for African Americans and other people of color? Will the Center for Individual Rights ride to the rescue of the White women who may be unfairly nudged out of positions for which they are "qualified" in…

  18. Instructional Rounds in Action

    ERIC Educational Resources Information Center

    Roberts, John E.

    2012-01-01

    "Instructional Rounds in Action" is an invaluable guide for those involved in implementing instructional rounds as the foundation and framework for systemic improvement in schools. Over the past few years, districts across the United States, Canada, and Australia have begun implementing "instructional rounds," a set of ideas and practices for…

  19. From Intuition to Action

    ERIC Educational Resources Information Center

    Principal, 2012

    2012-01-01

    The vast majority of principals intuitively believe that the arts belong in schools and in every child's life. Now is the time to take action on your intuition--and become an instructional leader for the arts, just as you are for every core subject. Arts-engaged principals share strategies for becoming instructional leaders for the arts.

  20. Action Research in Practice

    ERIC Educational Resources Information Center

    Piggot-Irvine, Eileen

    2009-01-01

    Action research places a powerful tool for school improvement in the hands of teachers. By highlighting the outcomes that are possible and presenting clear steps in the research process, this book is one to encourage anyone who is seeking to implement evidence-based school improvement. Eileen Piggot-Irvine uses her Problem Resolving Action…

  1. Conjugate flow action functionals

    SciTech Connect

    Venturi, Daniele

    2013-11-15

    We present a new general framework to construct an action functional for a non-potential field theory. The key idea relies on representing the governing equations relative to a diffeomorphic flow of curvilinear coordinates which is assumed to be functionally dependent on the solution field. Such flow, which will be called the conjugate flow, evolves in space and time similarly to a physical fluid flow of classical mechanics and it can be selected in order to symmetrize the Gâteaux derivative of the field equations with respect to suitable local bilinear forms. This is equivalent to requiring that the governing equations of the field theory can be derived from a principle of stationary action on a Lie group manifold. By using a general operator framework, we obtain the determining equations of such manifold and the corresponding conjugate flow action functional. In particular, we study scalar and vector field theories governed by second-order nonlinear partial differential equations. The identification of transformation groups leaving the conjugate flow action functional invariant could lead to the discovery of new conservation laws in fluid dynamics and other disciplines.

  2. College Comedy and Action

    ERIC Educational Resources Information Center

    Moore, Rosanna

    1977-01-01

    A few materials such as yarn and scraps of paper and cloth can provide the media for recording limitless ideas from the imaginations of students. With a little encouragement and a few suggestions of actions, emotions, exaggerations and activities students will produce a vast array of amusing characters. (Author)

  3. Promoting Environmental Action.

    ERIC Educational Resources Information Center

    Bowyer, John

    1994-01-01

    Outlines a lesson on the extinction process allowing students to better understand why and how species become endangered before they attempt to take action on this problem. Provides background information and describes several suggested methodologies, evaluation and enrichment ideas, six resources, and two references. (LZ)

  4. Literacy Education Action.

    ERIC Educational Resources Information Center

    Clymer, Carol

    The Literacy Education Action (LEA) program was established in the fall of 1985 under the initiative of the president of the El Paso Community College (Texas). During 1985 and 1986, LEA concentrated on developing its own literacy tutoring program, including recruiting and training volunteers and community members with reading skills below the…

  5. Angels in Action

    ERIC Educational Resources Information Center

    Stylianou, Xanthippi Cynthia

    2009-01-01

    In this article, the author discusses the importance of the placement of action lines to show the direction of movement. The author shows some visuals of angels and discusses in details the texture of the wings, the hair and the clothing.

  6. Economics Action Pack.

    ERIC Educational Resources Information Center

    McDonald's Corp., Oak Brook, IL.

    One of five McDonald's Action Packs, this learning package introduces intermediate grade students to basic economic concepts. The fourteen activities include the topics of consumption (4 activities), production (5), the market system (3), a pretest, and a posttest. Specific titles under consumption include The Wonderful Treasure Tree (introduction…

  7. Sustainability as Moral Action

    ERIC Educational Resources Information Center

    Dunn, Merrily S.; Hart-Steffes, Jeanne S.

    2012-01-01

    When one considers sustainability as a moral action, there are equally complex realities at hand--climate change, resource depletion, water and land rights. One author describes this broad sense of sustainability as "the connection of specific social and environmental problems to the functioning of human and ecological systems" (Jenkins, 2011).…

  8. Affirmative Action Plan.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Education, Oklahoma City.

    As mandated by law, this 1983 revision describes the Oklahoma State Department of Education's Affirmative Action Plan and analyzes the employment patterns of the department's work force for that year in light of equal employment opportunity goals. Following a brief policy statement, the development, dissemination, and implementation of the plan…

  9. Conjugate flow action functionals

    NASA Astrophysics Data System (ADS)

    Venturi, Daniele

    2013-11-01

    We present a new general framework to construct an action functional for a non-potential field theory. The key idea relies on representing the governing equations relative to a diffeomorphic flow of curvilinear coordinates which is assumed to be functionally dependent on the solution field. Such flow, which will be called the conjugate flow, evolves in space and time similarly to a physical fluid flow of classical mechanics and it can be selected in order to symmetrize the Gâteaux derivative of the field equations with respect to suitable local bilinear forms. This is equivalent to requiring that the governing equations of the field theory can be derived from a principle of stationary action on a Lie group manifold. By using a general operator framework, we obtain the determining equations of such manifold and the corresponding conjugate flow action functional. In particular, we study scalar and vector field theories governed by second-order nonlinear partial differential equations. The identification of transformation groups leaving the conjugate flow action functional invariant could lead to the discovery of new conservation laws in fluid dynamics and other disciplines.

  10. Holography in action

    SciTech Connect

    Kolekar, Sanved; Padmanabhan, T.

    2010-07-15

    The Einstein-Hilbert action and its natural generalizations to higher dimensions (like the Lanczos-Lovelock action) have certain peculiar features. All of them can be separated into a bulk and a surface term, with a specific (''holographic'') relationship between the two, so that either term can be used to extract information about the other. Further, the surface term leads to entropy of the horizons on shell. It has been argued in the past that these features are impossible to understand in the conventional approach but find a natural explanation if we consider gravity as an emergent phenomenon. We provide further support for this point of view in this paper. We describe an alternative decomposition of the Einstein-Hilbert action and the Lanczos-Lovelock action into a new pair of surface and bulk terms, such that the surface term becomes the Wald entropy on a horizon and the bulk term is the energy density (which is the Arnowitt-Deser-Misner Hamiltonian density for Einstein gravity). We show that this new pair also obeys a holographic relationship, and we give a thermodynamic interpretation of this relation in this context. Since the bulk and surface terms, in this decomposition, are related to the energy and entropy, the holographic condition can be thought of as analogous to inverting the expression for entropy given as a function of energy S=S(E,V) to obtain the energy E=E(S,V) in terms of the entropy in a normal thermodynamic system. Thus the holographic nature of the action allows us to relate the descriptions of the same system in terms of two different thermodynamic potentials. Some further possible generalizations and implications are discussed.

  11. A database of whole-body action videos for the study of action, emotion, and untrustworthiness.

    PubMed

    Keefe, Bruce D; Villing, Matthias; Racey, Chris; Strong, Samantha L; Wincenciak, Joanna; Barraclough, Nick E

    2014-12-01

    We present a database of high-definition (HD) videos for the study of traits inferred from whole-body actions. Twenty-nine actors (19 female) were filmed performing different actions-walking, picking up a box, putting down a box, jumping, sitting down, and standing and acting-while conveying different traits, including four emotions (anger, fear, happiness, sadness), untrustworthiness, and neutral, where no specific trait was conveyed. For the actions conveying the four emotions and untrustworthiness, the actions were filmed multiple times, with the actor conveying the traits with different levels of intensity. In total, we made 2,783 action videos (in both two-dimensional and three-dimensional format), each lasting 7 s with a frame rate of 50 fps. All videos were filmed in a green-screen studio in order to isolate the action information from all contextual detail and to provide a flexible stimulus set for future use. In order to validate the traits conveyed by each action, we asked participants to rate each of the actions corresponding to the trait that the actor portrayed in the two-dimensional videos. To provide a useful database of stimuli of multiple actions conveying multiple traits, each video name contains information on the gender of the actor, the action executed, the trait conveyed, and the rating of its perceived intensity. All videos can be downloaded free at the following address: http://www-users.york.ac.uk/~neb506/databases.html. We discuss potential uses for the database in the analysis of the perception of whole-body actions. PMID:24584971

  12. Avulsion in Action: Reconstruction and Modelling Sedimentation Pace and Upstream Flood Water Levels Following a Medieval Tidal-River Diversion and Storm Surge Catastrophe, The Netherlands, 1421-1750 AD

    NASA Astrophysics Data System (ADS)

    Cohen, K.; Kleinhans, M. G.; Weerts, H.

    2010-12-01

    Deltaic land inundated by storm surges may reform by sedimentation from natural or human-induced river diversions. This is a well-known trigger mechanism for creation of new channels in coastal plains and deltas, which may develop into main channels and lead to abandonment of older (avulsion), particularly in the downstream parts of deltas that host tidal rivers. These new channels develop as part of deltaic splay complexes that heal initial diversion scars and fill up flooded basins at a certain pace. We study a case with excellent historical and geological data of a diversion of the river Rhine following catastrophic inundations (1421-1424 AD) into medieval reclaimed land. Numerical modelling of deltaic splay and channel development is combined with reconstructions from historical maps and geological data. This yields detailed insight in pacing of splay sedimentation and changing hydrodynamics in the channel upstream of the diversion in the two centuries following the inundation. The equivalent of the full sand budget of the river Rhine was effectively trapped in the developing splay. The tidal-avulsion splay evolution on aspects is similar to that of fluvial crevassing into flood basins documented for settings lacking ‘downstream’ tidal control. The typical small-scale delta-lobe avulsion cycles: mouth bar formation, backward sedimentation, upstream avulsion, channel progradation and mouth bar formation are reproduced in the splay-modelling. The pacing of splay development, however, is relatively fast due to the presence of tides and the water depth in the receiving basin. The diversion had a strong upstream impact, in particular on water levels in the feeding river channel at stages of peak flow. For two centuries levels were significantly raised, because bifurcation-imposed reduced transport capacity and associated sedimentation at the diversion site increased hydraulic roughness and hampered flow. These findings have implications regarding flood

  13. Corrective Action Plan for Corrective Action Unit 562: Waste Systems, Nevada National Security Site, Nevada

    SciTech Connect

    NSTec Environmental Restoration

    2011-04-30

    This Corrective Action Plan has been prepared for Corrective Action Unit (CAU) 562, Waste Systems, in accordance with the Federal Facility Agreement and Consent Order (1996; as amended March 2010). CAU 562 consists of 13 Corrective Action Sites (CASs) located in Areas 2, 23, and 25 of the Nevada National Security Site. Site characterization activities were performed in 2009 and 2010, and the results are presented in Appendix A of the Corrective Action Decision Document for CAU 562. The scope of work required to implement the recommended closure alternatives is summarized. (1) CAS 02-26-11, Lead Shot, will be clean closed by removing shot. (2) CAS 02-44-02, Paint Spills and French Drain, will be clean closed by removing paint and contaminated soil. As a best management practice (BMP), asbestos tile will be removed. (3) CAS 02-59-01, Septic System, will be clean closed by removing septic tank contents. As a BMP, the septic tank will be removed. (4) CAS 02-60-01, Concrete Drain, contains no contaminants of concern (COCs) above action levels. No further action is required; however, as a BMP, the concrete drain will be removed. (5) CAS 02-60-02, French Drain, was clean closed. Corrective actions were completed during corrective action investigation activities. As a BMP, the drain grates and drain pipe will be removed. (6) CAS 02-60-03, Steam Cleaning Drain, will be clean closed by removing contaminated soil. As a BMP, the steam cleaning sump grate and outfall pipe will be removed. (7) CAS 02-60-04, French Drain, was clean closed. Corrective actions were completed during corrective action investigation activities. (8) CAS 02-60-05, French Drain, will be clean closed by removing contaminated soil. (9) CAS 02-60-06, French Drain, contains no COCs above action levels. No further action is required. (10) CAS 02-60-07, French Drain, requires no further action. The french drain identified in historical documentation was not located during corrective action investigation

  14. Goal anticipation during action observation is influenced by synonymous action capabilities, a puzzling developmental study.

    PubMed

    Gredebäck, Gustaf; Kochukhova, Olga

    2010-04-01

    Eighteen- and 25-month-old human toddlers' ability to manually solve a puzzle and their ability to anticipate the goal during observation of similar actions were investigated. Results demonstrate that goal anticipation during action observation is dependent on manual ability, both on a group level (only 25-month-olds solved the manual task and anticipated the goal during observation) and individually within the older age group (r (xy) = 0.53). These findings suggests a connection between manual ability and the ability to anticipate the goal of others' actions in toddlers, in accordance with the direct matching hypothesis. PMID:20041233

  15. Action Recognition Using Nonnegative Action Component Representation and Sparse Basis Selection.

    PubMed

    Wang, Haoran; Yuan, Chunfeng; Hu, Weiming; Ling, Haibin; Yang, Wankou; Sun, Changyin

    2014-02-01

    In this paper, we propose using high-level action units to represent human actions in videos and, based on such units, a novel sparse model is developed for human action recognition. There are three interconnected components in our approach. First, we propose a new context-aware spatial-temporal descriptor, named locally weighted word context, to improve the discriminability of the traditionally used local spatial-temporal descriptors. Second, from the statistics of the context-aware descriptors, we learn action units using the graph regularized nonnegative matrix factorization, which leads to a part-based representation and encodes the geometrical information. These units effectively bridge the semantic gap in action recognition. Third, we propose a sparse model based on a joint l2,1-norm to preserve the representative items and suppress noise in the action units. Intuitively, when learning the dictionary for action representation, the sparse model captures the fact that actions from the same class share similar units. The proposed approach is evaluated on several publicly available data sets. The experimental results and analysis clearly demonstrate the effectiveness of the proposed approach. PMID:26270909

  16. Action Research and the School Counselor

    ERIC Educational Resources Information Center

    Gamsky, Neal R.

    1970-01-01

    Points to need for counselors to be involved in research activities, while at the same time examining reasons why they are not. Suggests that counselors have an obligation to divest themselves of the rigidity that hampers research at the local level, and attempt to conduct action research. (CJ)

  17. Training as an Affirmative Action Strategy.

    ERIC Educational Resources Information Center

    Hadley, Gay B.; And Others

    This manual is intended to help organizations design training programs that assist in the achievement of affirmative action. These topics are discussed in section I: the importance of work force diversity; recruiting and training women and minority employees at all levels of the organization; and the costs and benefits of training as an…

  18. Positive Action. What Works Clearinghouse Intervention Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2006

    2006-01-01

    "Positive Action," a K-12 program, aims to promote a positive self-concept, character development, healthy behavior, and social-emotional skills and to reduce disruptive and problem behavior. The curricula for elementary and middle school students each have seven units per kit, with nine kits per grade level. The high school curriculum has six…

  19. New Perspectives on Action Learning: Developing Criticality

    ERIC Educational Resources Information Center

    Anderson, Lisa; Thorpe, Richard

    2004-01-01

    This article discusses the role of criticality in action learning and in Master's level management education; examines approaches to developing criticality through social constructionist approaches to learning and illustrates how a heightened consciousness of language use by managers can be used to develop critical reflection. Examines critical…

  20. Public Health Action Model for Cancer Survivorship

    PubMed Central

    Moore, Angela R.; Buchanan, Natasha D.; Fairley, Temeika L.; Smith, Judith Lee

    2016-01-01

    Long-term objectives associated with cancer survivors have been suggested by Healthy People 2020, including increasing the proportion of survivors living beyond 5 years after diagnosis and improving survivors’ mental and physical health-related quality of life. Prior to reaching these objectives, several intermediate steps must be taken to improve the physical, social, emotional, and financial well-being of cancer survivors. Public health has a role in developing strategic, actionable, and measurable approaches to facilitate change at multiple levels to improve the lives of survivors and their families. The social ecological model has been used by the public health community as the foundation of multilevel intervention design and implementation, encouraging researchers and practitioners to explore methods that promote internal and external changes at the individual, interpersonal, organizational, community, and policy levels. The survivorship community, including public health professionals, providers, policymakers, survivors, advocates, and caregivers, must work collaboratively to identify, develop, and implement interventions that benefit cancer survivors. The National Action Plan for Cancer Survivorship highlights public health domains and associated strategies that can be the impetus for collaboration between and among the levels in the social ecological model and are integral to improving survivor outcomes. This paper describes the Public Health Action Model for Cancer Survivorship, an integrative framework that combines the National Action Plan for Cancer Survivorship with the social ecological model to demonstrate how interaction among the various levels may promote better outcomes for survivors. PMID:26590641

  1. Science education and everyday action

    NASA Astrophysics Data System (ADS)

    McCann, Wendy Renee Sherman

    2001-07-01

    This dissertation addresses three related tasks and issues in the larger field of science education. The first is to review of the several uses of "everydayness" at play in the science education literature, and in the education and social science literatures more generally. Four broad iterations of everydayness were found in science education, and these were traced and analyzed to develop their similarities, and contradictions. It was concluded that despite tendencies in science education research to suppose a fundamental demarcation either between professional science and everyday life, or between schools and everyday life, all social affairs, including professional science and activity in schools, are continuous with everyday life, and consist fundamentally in everyday, ordinary mundane actions which are ordered and organized by the participants to those social activities and occasions. The second task for this dissertation was to conduct a naturalistic, descriptive study of undergraduate-level physics laboratory activities from the analytic perspective of ethnomethodology. The study findings are presented as closely-detailed analysis of the students' methods of following their instructions and 'fitting' their observed results to a known scientific concept or principle during the enactment of their classroom laboratory activities. Based on the descriptions of students' practical work in following instructions and 'fitting'. The characterization of school science labs as an "experiment-demonstration hybrid" is developed. The third task of this dissertation was to synthesize the literature review and field study findings in order to clarify what science educators could productively mean by "everydayness", and to suggest what understandings of science education the study of everyday action recommends. It is argued that the significance of the 'experiment-demo hybrid' characterization must be seen in terms of an alternate program for science education research, which

  2. A Metadata Action Language

    NASA Technical Reports Server (NTRS)

    Golden, Keith; Clancy, Dan (Technical Monitor)

    2001-01-01

    The data management problem comprises data processing and data tracking. Data processing is the creation of new data based on existing data sources. Data tracking consists of storing metadata descriptions of available data. This paper addresses the data management problem by casting it as an AI planning problem. Actions are data-processing commands, plans are dataflow programs and goals are metadata descriptions of desired data products. Data manipulation is simply plan generation and execution, and a key component of data tracking is inferring the effects of an observed plan. We introduce a new action language for data management domains, called ADILM. We discuss the connection between data processing and information integration and show how a language for the latter must be modified to support the former. The paper also discusses information gathering within a data-processing framework, and show how ADILM metadata expressions are a generalization of Local Completeness.

  3. Finding minimal action sequences with a simple evaluation of actions

    PubMed Central

    Shah, Ashvin; Gurney, Kevin N.

    2014-01-01

    Animals are able to discover the minimal number of actions that achieves an outcome (the minimal action sequence). In most accounts of this, actions are associated with a measure of behavior that is higher for actions that lead to the outcome with a shorter action sequence, and learning mechanisms find the actions associated with the highest measure. In this sense, previous accounts focus on more than the simple binary signal of “was the outcome achieved?”; they focus on “how well was the outcome achieved?” However, such mechanisms may not govern all types of behavioral development. In particular, in the process of action discovery (Redgrave and Gurney, 2006), actions are reinforced if they simply lead to a salient outcome because biological reinforcement signals occur too quickly to evaluate the consequences of an action beyond an indication of the outcome's occurrence. Thus, action discovery mechanisms focus on the simple evaluation of “was the outcome achieved?” and not “how well was the outcome achieved?” Notwithstanding this impoverishment of information, can the process of action discovery find the minimal action sequence? We address this question by implementing computational mechanisms, referred to in this paper as no-cost learning rules, in which each action that leads to the outcome is associated with the same measure of behavior. No-cost rules focus on “was the outcome achieved?” and are consistent with action discovery. No-cost rules discover the minimal action sequence in simulated tasks and execute it for a substantial amount of time. Extensive training, however, results in extraneous actions, suggesting that a separate process (which has been proposed in action discovery) must attenuate learning if no-cost rules participate in behavioral development. We describe how no-cost rules develop behavior, what happens when attenuation is disrupted, and relate the new mechanisms to wider computational and biological context. PMID:25506326

  4. Reactions of a cyclodimethylsiloxane (Me2SiO)6 with silver salts of weakly coordinating anions; crystal structures of [Ag(Me2SiO)6][Al] ([Al] = [FAl{OC(CF3)3}3], [Al{OC(CF3)3}4]) and their comparison with [Ag(18-crown-6)]2[SbF6]2.

    PubMed

    Cameron, T Stanley; Decken, Andreas; Krossing, Ingo; Passmore, Jack; Rautiainen, J Mikko; Wang, Xinping; Zeng, Xiaoqing

    2013-03-18

    Two silver-cyclodimethylsiloxane cation salts [AgD6][Al] ([Al] = [Al(ORF)4](1) or [FAl(OR(F))3](2), R(F) = C(CF3)3, D = Me2SiO) were prepared by the reactions of Ag[Al] with D6 in SO2(l). For a comparison the [Ag(18-crown-6)]2[SbF6]2(3) salt was prepared by the reaction of Ag[SbF6] and 18-crown-6 in SO2(l). The compounds were characterized by IR, multinuclear NMR, and single crystal X-ray crystallography. The structures of 1 and 2 show that D6 acts as a pseudo crown ether toward Ag(+). The stabilities and bonding of [MDn](+) and [M(18-crown-6)](+) (M = Ag, Li, n = 4-8) complexes were studied with theoretical calculations. The calculations predicted that D6 adopts a puckered C(i) symmetric structure in the gas phase in contrast to previous reports. 18-Crown-6 was calculated to bind more strongly to Li(+) and Ag(+) than D6. (29)Si[(1)H] NMR results in solution, and calculations in the gas phase established that a hard Lewis acid Li(+) binds more strongly to D6 than Ag(+). A comparison of the [MD(n)](+) complex stabilities showed D7 to form the most stable metal complexes in the gas phase and the solid state and explained why [AgD7][SbF6] was isolated in a previous reaction where ring transformations resulted in an equilibrium of [AgD(n)](+) complexes. In contrast, the isolations of 1 and 2 were possible because the corresponding equilibrium of [AgD(n)](+) complexes was not observed with [Al](-) anions. The formation of the dinuclear complex salt 3 instead of the corresponding mononuclear complex salt was shown to be driven by the gain in lattice enthalpy in the solid state. The bonding to Li(+) in D6 and 18-crown-6 metal complexes was described by a quantum theory of atoms in molecules (QTAIM) analysis to be mostly electrostatic while the bonding to Ag(+) also had a significant charge transfer component. The charge transfer from both D6 and 18-crown-6 to Ag(+) and Li(+) metal ions was depicted by the QTAIM analysis to be of similar strength, and the difference in the

  5. Atoms in Action

    SciTech Connect

    2009-01-01

    This movie produced with Berkeley Lab's TEAM 0.5 microscope shows the growth of a hole and the atomic edge reconstruction in a graphene sheet. An electron beam focused to a spot on the sheet blows out the exposed carbon atoms to make the hole. The carbon atoms then reposition themselves to find a stable configuration. http://newscenter.lbl.gov/press-releases/2009/03/26/atoms-in-action/

  6. Empirical microeconomics action functionals

    NASA Astrophysics Data System (ADS)

    Baaquie, Belal E.; Du, Xin; Tanputraman, Winson

    2015-06-01

    A statistical generalization of microeconomics has been made in Baaquie (2013), where the market price of every traded commodity, at each instant of time, is considered to be an independent random variable. The dynamics of commodity market prices is modeled by an action functional-and the focus of this paper is to empirically determine the action functionals for different commodities. The correlation functions of the model are defined using a Feynman path integral. The model is calibrated using the unequal time correlation of the market commodity prices as well as their cubic and quartic moments using a perturbation expansion. The consistency of the perturbation expansion is verified by a numerical evaluation of the path integral. Nine commodities drawn from the energy, metal and grain sectors are studied and their market behavior is described by the model to an accuracy of over 90% using only six parameters. The paper empirically establishes the existence of the action functional for commodity prices that was postulated to exist in Baaquie (2013).

  7. Archetypes as action patterns.

    PubMed

    Hogenson, George B

    2009-06-01

    The discovery of mirror neurons by researchers at the University of Parma promises to radically alter our understanding of fundamental cognitive and affective states. This paper explores the relationship of mirror neurons to Jung's theory of archetypes and proposes that archetypes may be viewed as elementary action patterns. The paper begins with a review of a proposed interpretation of the fainting spells of S. Freud in his relationship with Jung as an example of an action pattern that also defines an archetypal image. The challenge that mirror neurons present to traditional views in analytical psychology and psychoanalysis, however, is that they operate without recourse to a cognitive processing element. This is a position that is gaining increasing acceptance in other fields as well. The paper therefore reviews the most recent claims made by the Boston Process of Change Study Group as well as conclusions drawn from dynamic systems views of development and theoretical robotics to underline the conclusion that unconscious agency is not a requirement for coherent action. It concludes with the suggestion that this entire body of research may lead to the conclusion that the dynamic unconscious is an unnecessary hypothesis in psychoanalysis and analytical psychology. PMID:19531123

  8. Platform for Action: update.

    PubMed

    1995-01-01

    The Center for Women's Global Leadership (CWGL) has collaborated in the preparation of amendments and strategies designed to withstand the challenges being posed to the Platform for Action of the Fourth World Conference on Women. Specific challenges include the inappropriate use of the word "universal" to modify "human rights." This implies that some human rights are less than universal. The strategy proposed is to accept the use of the word "universal" in this context only when it affirms principles of universality contained in the Vienna Programme of Action and not where its use would restrict the rights to which women are entitled. A second concern is over the use of the word "equity" rather than "equality" when referring to gender relations. The use of these terms will be carefully monitored to insure that "equity" not be used to undermine the principle of gender equality. The third concern is the efforts of some governments to hinder the integration of women's human rights throughout the UN system. Such efforts will be opposed. Fourth, the CWGL will seek the inclusion of language which recognizes the barriers that different groups of women face when trying to secure their rights. Finally, the CWGL will propose inclusion of language recognizing and protecting sexual orientation rights. The CWGL is also going to work to translate the abstract language of the Platform for Action into political organizing potential to insure that governments will follow through on their agreements. PMID:12346441

  9. Action spectra for photosynthetic inhibition

    NASA Technical Reports Server (NTRS)

    Caldwell, M. M.; Flint, S.; Camp, L. B.

    1981-01-01

    The ultraviolet action spectrum for photosynthesis inhibition was determined to fall between that of the general DNA action spectrum and the generalized plant action spectrum. The characteristics of this action spectrum suggest that a combination of pronounced increase in effectiveness with decreasing wavelength, substantial specificity for the UV-B waveband, and very diminished response in the UV-A waveband result in large radiation amplification factors when the action spectra are used as weighting functions. Attempted determination of dose/response relationships for leaf disc inhibition provided inconclusive data from which to deconvolute an action spectrum.

  10. 10 CFR 1021.400 - Level of NEPA review.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Level of NEPA review. 1021.400 Section 1021.400 Energy... Classes of Actions § 1021.400 Level of NEPA review. (a) This subpart identifies DOE actions that normally... proceed with the level of NEPA review indicated for that class of actions, unless there are...

  11. The specificity of action knowledge in sensory and motor systems

    PubMed Central

    Watson, Christine E.; Cardillo, Eileen R.; Bromberger, Bianca; Chatterjee, Anjan

    2014-01-01

    Neuroimaging studies have found that sensorimotor systems are engaged when participants observe actions or comprehend action language. However, most of these studies have asked the binary question of whether action concepts are embodied or not, rather than whether sensory and motor areas of the brain contain graded amounts of information during putative action simulations. To address this question, we used repetition suppression (RS) functional magnetic resonance imaging to determine if functionally-localized motor movement and visual motion regions-of-interest (ROI) and two anatomical ROIs (inferior frontal gyrus, IFG; left posterior middle temporal gyrus, pMTG) were sensitive to changes in the exemplar (e.g., two different people “kicking”) or representational format (e.g., photograph or schematic drawing of someone “kicking”) within pairs of action images. We also investigated whether concrete versus more symbolic depictions of actions (i.e., photographs or schematic drawings) yielded different patterns of activation throughout the brain. We found that during a conceptual task, sensory and motor systems represent actions at different levels of specificity. While the visual motion ROI did not exhibit RS to different exemplars of the same action or to the same action depicted by different formats, the motor movement ROI did. These effects are consistent with “person-specific” action simulations: if the motor system is recruited for action understanding, it does so by activating one's own motor program for an action. We also observed significant repetition enhancement within the IFG ROI to different exemplars or formats of the same action, a result that may indicate additional cognitive processing on these trials. Finally, we found that the recruitment of posterior brain regions by action concepts depends on the format of the input: left lateral occipital cortex and right supramarginal gyrus responded more strongly to symbolic depictions of actions than

  12. The specificity of action knowledge in sensory and motor systems.

    PubMed

    Watson, Christine E; Cardillo, Eileen R; Bromberger, Bianca; Chatterjee, Anjan

    2014-01-01

    Neuroimaging studies have found that sensorimotor systems are engaged when participants observe actions or comprehend action language. However, most of these studies have asked the binary question of whether action concepts are embodied or not, rather than whether sensory and motor areas of the brain contain graded amounts of information during putative action simulations. To address this question, we used repetition suppression (RS) functional magnetic resonance imaging to determine if functionally-localized motor movement and visual motion regions-of-interest (ROI) and two anatomical ROIs (inferior frontal gyrus, IFG; left posterior middle temporal gyrus, pMTG) were sensitive to changes in the exemplar (e.g., two different people "kicking") or representational format (e.g., photograph or schematic drawing of someone "kicking") within pairs of action images. We also investigated whether concrete versus more symbolic depictions of actions (i.e., photographs or schematic drawings) yielded different patterns of activation throughout the brain. We found that during a conceptual task, sensory and motor systems represent actions at different levels of specificity. While the visual motion ROI did not exhibit RS to different exemplars of the same action or to the same action depicted by different formats, the motor movement ROI did. These effects are consistent with "person-specific" action simulations: if the motor system is recruited for action understanding, it does so by activating one's own motor program for an action. We also observed significant repetition enhancement within the IFG ROI to different exemplars or formats of the same action, a result that may indicate additional cognitive processing on these trials. Finally, we found that the recruitment of posterior brain regions by action concepts depends on the format of the input: left lateral occipital cortex and right supramarginal gyrus responded more strongly to symbolic depictions of actions than concrete

  13. Improving Teaching with Collaborative Action Research: An ASCD Action Tool

    ERIC Educational Resources Information Center

    Cunningham, Diane

    2011-01-01

    Once you've established a professional learning community (PLC), you need to get this ASCD (Association for Supervision and Curriculum Development) action tool to ensure that your PLC stays focused on addressing teaching methods and student learning problems. This ASCD action tool explains how your PLC can use collaborative action research to…

  14. On the Inclusion of Externally Controlled Actions in Action Planning

    ERIC Educational Resources Information Center

    Tsai, Jessica Chia-Chin; Knoblich, Gunther; Sebanz, Natalie

    2011-01-01

    According to ideomotor theories, perceiving action effects produced by others triggers corresponding action representations in the observer. We tested whether this principle extends to actions performed by externally controlled limbs and tools. Participants performed a go-no-go version of a spatial compatibility task in which their own actions…

  15. Paving the Path to Success. Data for Action 2014. Summary

    ERIC Educational Resources Information Center

    Data Quality Campaign, 2014

    2014-01-01

    At the federal level, leaders can promote policies that reduce burdens on states, encourage collaboration across agencies, and help build the capacity of stakeholders to use data while ensuring the privacy of student information. The annual "Data for Action" survey measures states' progress toward achieving the 10 State Actions to Ensure…

  16. Infants Recognize Similar Goals across Dissimilar Actions Involving Object Manipulation

    ERIC Educational Resources Information Center

    Olofson, Eric L.; Baldwin, Dare

    2011-01-01

    We investigated infants' ability to recognize the similarity between observed and implied goals when actions differed in surface-level motion details. In two experiments, 10- to 12-month-olds were habituated to an actor manipulating an object and then shown test actions in which the actor contacted the object with a novel hand configuration that…

  17. Alternatives/action plan report for outfall 17

    SciTech Connect

    1994-11-01

    This Document contains information pertaining to alternatives/action associated with controlling ammonia entering through outfall 17. This document identifies the location of contaminate source, the ammonia concentration levels entering East Fork Poplar Creek, and the action taken to reduce/eliminate the toxicity problem.

  18. Research, Action, and Participation: The Merchant Shipping Case.

    ERIC Educational Resources Information Center

    Walton, Richard E.; Gaffney, Michael E.

    1989-01-01

    Focuses on the international industry of merchant shipping to explore strategies used to promote organizational change over the past 20 years. This case study emphasizes the advantages of melding knowledge and action in participatory action. Points out the importance of the design and management of industry-level forums in assuring the success.…

  19. Developing an action concept inventory

    NASA Astrophysics Data System (ADS)

    McGinness, Lachlan P.; Savage, C. M.

    2016-06-01

    We report on progress towards the development of an Action Concept Inventory (ACI), a test that measures student understanding of action principles in introductory mechanics and optics. The ACI also covers key concepts of many-paths quantum mechanics, from which classical action physics arises. We used a multistage iterative development cycle for incorporating expert and student feedback into successive revisions of the ACI. The student feedback, including think-aloud interviews, enabled us to identify their misconceptions about action physics.

  20. Strong acoustic wave action

    NASA Astrophysics Data System (ADS)

    Gokhberg, M. B.

    1983-07-01

    Experiments devoted to acoustic action on the atmosphere-magnetosphere-ionosphere system using ground based strong explosions are reviewed. The propagation of acoustic waves was observed by ground observations over 2000 km in horizontal direction and to an altitude of 200 km. Magnetic variations up to 100 nT were detected by ARIEL-3 satellite near the epicenter of the explosion connected with the formation of strong field aligned currents in the magnetosphere. The enhancement of VLF emission at 800 km altitude is observed.

  1. Neurobiological actions of cysteamine

    SciTech Connect

    Brown, M.; Fisher, L.; Mason, R.T.; Rivier, J.; Vale, W.

    1985-06-01

    Somatostatin (SS)-related peptides act within discrete brain regions to inhibit adrenal epinephrine (E) secretion, to prevent hypothermia, and to produce hyperthermia. Depletion of brain concentrations of these SS-related peptides using cysteamine (CSH) or central administration of an SS receptor antagonist increases adrenal E secretion and impairs thermoregulation. These actions of CSH and the SS receptor antagonist are reversed by administration of SS into the central nervous system. These results support the hypothesis that endogenous brain SS-related peptides are involved in the regulation of adrenal E secretion and thermoregulation.

  2. 3RS action plan

    SciTech Connect

    Not Available

    1990-01-01

    The goal of the Solid Waste Interim Steering Committee (SWISC) process is to develop a long-term waste management system for the Greater Toronto Area (GTA), to be in place by 1996, which is environmentally, socially, economically and technically sound. This background report is being released to the public and member Regional Councils to facilitate input to the SWISC planning process. The report documents current reduction, reuse and recycling initiatives in the GTA, identifies opportunities for coordination and collaboration among the GTA communities, and develops an action plan for improving the effectiveness of the reduction, reuse and recycling efforts within the GTA.

  3. VIOLENT FRAMES IN ACTION

    SciTech Connect

    Sanfilippo, Antonio P.; McGrath, Liam R.; Whitney, Paul D.

    2011-11-17

    We present a computational approach to radical rhetoric that leverages the co-expression of rhetoric and action features in discourse to identify violent intent. The approach combines text mining and machine learning techniques with insights from Frame Analysis and theories that explain the emergence of violence in terms of moral disengagement, the violation of sacred values and social isolation in order to build computational models that identify messages from terrorist sources and estimate their proximity to an attack. We discuss a specific application of this approach to a body of documents from and about radical and terrorist groups in the Middle East and present the results achieved.

  4. Climate Literacy: Springboard to Action

    NASA Astrophysics Data System (ADS)

    Long, B.; Bader, D.

    2011-12-01

    Research indicates that the public views zoos and aquariums as reliable and trusted sources for information on conservation (Ocean Project, 2009). The Aquarium of the Pacific is using NOAA's Science on a Sphere (SOS)° and linked flat screens to convey climate concepts to the public and serve as a model for how aquariums can promote climate literacy. The Ocean Science Center houses the SOS and is designed to immerse our visitors in an experience that extends from the sphere, to our live animals, and to our public programming. The first SOS exhibit, the sea level rise story, opened as the cornerstone of an aquarium-wide climate literacy strategy. Large panels next to the SOS prompts visitors to pledge actions to reduce their personal carbon footprint. The exhibit objectives were to provide a visual presentation that conveys a dramatic story about sea level rise, and to engage the audience in confronting the impact of sea level rise, and the local implications. The Aquarium utilized Yale's Six Americas survey instrument during summer 2010 to measure our audience interpretations of and responses to climate change. The survey showed that 78% of visitors categorized themselves as either alarmed or concerned about climate change, greater than the national average. Thus our climate literacy programs do not focus on convincing visitors of climate change and its causes, but on encouraging adaptive responses to varying scenarios. University of California, Berkeley, Lawrence Hall of Science Center for Research Evaluation and Assessment (REA) conducted a pre-opening evaluation of the exhibit's impact. The participants, 58% of whom were families with children, did not want to know more about climate change, but wanted tangible activities they could engage in to mitigate human induced effects, and more details about the impact of climate change on marine animals. REA stated that, "the sea level rise programs (both facilitated and non-facilitated) are well positioned to be

  5. The Concept of Action Learning.

    ERIC Educational Resources Information Center

    Zuber-Skerritt, Ortrun

    2002-01-01

    Based on classic and emerging international literature, action learning is defined as learning form concrete experience and critical reflection on experience, focused on problem solving and change. Facilitators of action learning do not impose solutions but guide action learning teams through the process. (Contains 44 references.) (SK)

  6. Must Affirmative Action Be Divisive?

    ERIC Educational Resources Information Center

    Fineberg, Solomon Andhil

    1975-01-01

    Affirmative action is seen as causing dissension and cleavages in the civil rights coalition. Requisites suggested for winning support for affirmative action are thorough knowledge of its rationale and components, assuring whites they will not be pushed out of jobs, and a continued emphasis on the urgency for affirmative action. (Author/AM)

  7. Motor Execution Affects Action Prediction

    ERIC Educational Resources Information Center

    Springer, Anne; Brandstadter, Simone; Liepelt, Roman; Birngruber, Teresa; Giese, Martin; Mechsner, Franz; Prinz, Wolfgang

    2011-01-01

    Previous studies provided evidence of the claim that the prediction of occluded action involves real-time simulation. We report two experiments that aimed to study how real-time simulation is affected by simultaneous action execution under conditions of full, partial or no overlap between observed and executed actions. This overlap was analysed by…

  8. Action Research: Trends and Variations

    ERIC Educational Resources Information Center

    Beaulieu, Rodney J.

    2013-01-01

    Action research continues to grow as a research tradition, yet misconceptions about what it is and is not remains, even among scholars. For example, some mistakenly believe action research is only about professional development and is not a scholarly research approach. Some assume action research must be accomplished through a collaborative…

  9. Developing an Action Concept Inventory

    ERIC Educational Resources Information Center

    McGinness, Lachlan P.; Savage, C. M.

    2016-01-01

    We report on progress towards the development of an Action Concept Inventory (ACI), a test that measures student understanding of action principles in introductory mechanics and optics. The ACI also covers key concepts of many-paths quantum mechanics, from which classical action physics arises. We used a multistage iterative development cycle for…

  10. The Climate Change Action Plan: Technical supplement

    SciTech Connect

    Not Available

    1994-03-01

    This Technical Annex documents the assumptions and parameters used in developing the supporting analysis for the Climate Change Action Plan (the Plan) issued by President Clinton on October 19, 1993. The Annex is intended to meet the needs of independent energy and environmental analysts who wish to better understand the Plan, its analytical underpinnings, and the events that need to transpire for the emissions reductions called for in the Plan to be realized. The Plan documented in this Annex reflects the outcome of a wide-ranging effort by Government agencies and interested members of the public to develop and implement actions that can reduce net greenhouse gas emissions in the year 2000 to their aggregate 1990 level. Based on agency and public input, the Climate Change Mitigation Group, chaired by the White House Office on Environmental Policy, developed the Plan`s content. Many of the actions called for in the Plan are now underway, while others are in advanced planning pending congressional action on the fiscal year 1995 budget. The analysis supporting the Plan represents the results of an interagency effort. The US Department of Energy (DOE) was responsible for the integrated analysis of energy-related options, based on the analysis of individual energy-related options by DOE, the US Environmental Protection Agency (EPA), and the US Department of Transportation (DOT). EPA led in providing analysis for actions related to methane, hydrofluorocarbons, and perfluorocarbons. The US Department of Agriculture (USDA) led the analysis of carbon sequestration actions and cooperated with EPA in the analysis of actions to reduce nitrous oxide emissions.

  11. Linking differences in action perception with differences in action execution

    PubMed Central

    Macerollo, A.; Bose, S.; Ricciardi, L.; Edwards, M. J.

    2015-01-01

    Successful human social interactions depend upon the transmission of verbal and non-verbal signals from one individual to another. Non-verbal social communication is realized through our ability to read and understand information present in other people’s actions. It has been proposed that employing the same motor programs, we use to execute an action when observing the same action underlies this action understanding. The main prediction of this framework is that action perception should be strongly correlated with parameters of action execution. Here, we demonstrate that subjects’ sensitivity to observed movement speeds is dependent upon how quickly they themselves executed the observed action. This result is consistent with the motor theory of social cognition and suggests that failures in non-verbal social interactions between individuals may in part result from differences in how those individuals move. PMID:25691777

  12. Molecular and cellular level of action of digitalis.

    PubMed

    Charlemagne, D

    1993-04-01

    The pharmacological receptor of cardiac glycosides is the Na+/K(+)-ATPase which consists of a catalytic alpha (M(r) = 112,000) and glycosylated beta (M(r) = 35,000) subunit. The enzyme is responsible for the vectorial transport across the sarcolemma of three Na+ ions outward and two K+ ions inward against their electrochemical gradient. Specific inhibition of the Na+ pump by digitalis induces a positive inotropic effect by increasing the intracellular Na+ concentration which in turn induces an increase in the intracellular Ca2+ concentration by the Na+/Ca2+ exchange and an increase in the Ca2+ pool of the sarcoplasmic reticulum; toxic effects are observed at higher doses of cardiac glycosides leading to spontaneous calcium release from the sarcoplasmic reticulum. Three isoforms of the alpha catalytic subunit have been identified by molecular cloning. They share a high homology in the deduced amino acid sequence with eight transmembrane domains. The ouabain binding domain is located on the extracellular side and ouabain sensitivity depends mainly on the two residues at the border of the first extracellular domain. The isoforms differed by their ouabain sensitivity, are expressed in a tissue-specific and hormonally-regulated manner. Moreover, expression of the isoforms and their ouabain sensitivity vary from species to species with an alpha 1 isoform of very low affinity being the major isoform (80%) in the adult rat heart and an alpha 1 isoform of high affinity representing 50% of total alpha mRNA abundance in the human heart. Therefore the effect of digitalis on the heart depends mainly on the isoform which is expressed and on the regulation of their expression according to age, hormonal influence and pathology. PMID:7684015

  13. Sensitized action of low-level laser radiation mechanism

    NASA Astrophysics Data System (ADS)

    Chichuk, Tatyana V.; Stranadko, Eugeny P.; Lubchenko, G. N.; Podgornaya, E. V.; Pozdnyakova, E. E.; Klebanov, Gennady I.

    1999-12-01

    The goal of this work is to study the laser-induced photosensitized oxidation of lipids of the artificial (lyposomes) and cell's (erythrocytes, leukocytes) membranes and human blood lipoproteins. As a exogenous photosensitizers we are used hematoporphyrin derivatives (HPD) and sulfonated phthalocyanine aluminum (Pc). Irradiation was performed by helium-neon laser (632.8 nm). It was found out the increasing of the products of lipid oxidation in the suspensions of a lyposomes, human blood apo-(beta) -lipoproteins, erythrocytes and leucocytes. Accumulation of the lipid oxidation products depend on as irradiation dose as HPD or Pc concentrations. Interaction of photosensitizers with the lyposomes, lipoproteins and erythrocytes was investigated.

  14. [Study of residual levels of delayed-action neuroleptics].

    PubMed

    Furet, Y; Breteau, M; Etienne, T

    1991-01-01

    Pharmacokinetics of the depot antipsychotics are unclear and mainly depend on releasing from the depot site (according to a "flip-flop" model). Few data are available on residual plasma concentrations of those drugs. We have practiced 38 blood determinations among 15 patients treated by long-acting neuroleptics (10 by fluphenazine decanoate, 4 by flupentixol decanoate and 1 by pipotiazine palmitate). Radio Receptor Assay method was used (based on competition for dopamine receptors binding), with results expressed as chlorpromazine equivalents. They showed; a wide interindividual variability; considering each subject, intraindividual variability is attenuated; blood measurements are mainly higher than therapeutic ranges (especially for patients on fluphenazine decanoate). Those results might involve that some patients are overdosed, but other studies are needed in this way. PMID:1675816

  15. Wave action power plant

    SciTech Connect

    Lucia, L.V.

    1982-03-16

    A wave action power plant powered by the action of water waves has a drive shaft rotated by a plurality of drive units, each having a lever pivotally mounted on and extending from said shaft and carrying a weight, in the form of a float, which floats on the waves and rocks the lever up and down on the shaft. A ratchet mechanism causes said shaft to be rotated in one direction by the weight of said float after it has been raised by wave and the wave has passed, leaving said float free to move downwardly by gravity and apply its full weight to pull down on the lever and rotate the drive shaft. There being a large number of said drive units so that there are always some of the weights pulling down on their respective levers while other weights are being lifted by waves and thereby causing continuous rotation of the drive shaft in one direction. The said levers are so mounted that they may be easily raised to bring the weights into a position wherein they are readily accessible for cleaning the bottoms thereof to remove any accumulation of barnacles, mollusks and the like. There is also provided means for preventing the weights from colliding with each other as they independently move up and down on the waves.

  16. Ovarian actions of resveratrol.

    PubMed

    Ortega, Israel; Duleba, Antoni J

    2015-08-01

    Resveratrol, a natural polyphenol found in grapes, berries, and medicinal plants, exhibits antioxidant and anti-inflammatory activities and has been proposed to be a longevity-prolonging agent. There is also growing evidence that resveratrol has cardioprotective properties and beneficial effects on both glucose and lipid metabolism. Recently, several studies have examined the use of resveratrol as a therapeutic agent to treat numerous pathological and metabolic disorders. Herein, we present insights into the mechanisms of action, biological effects, and current evidence of actions of resveratrol on the ovary. In vitro, resveratrol inhibits proliferation and androgen production by theca-interstitial cells. Resveratrol also exerts a cytostatic, but not cytotoxic, effect on granulosa cells, while decreasing aromatization and vascular endothelial growth factor expression. In vivo, resveratrol treatment reduced the size of adipocytes and improved estrus cyclicity in the previously acyclic rat model of polycystic ovary syndrome (PCOS). In addition, resveratrol increased the ovarian follicular reserve and prolonged the ovarian life span in rats. Taken together, resveratrol emerges as a potential therapeutic agent to treat conditions associated with androgen excess, such as PCOS. The efficacy of resveratrol in the treatment of gynecological conditions requires further investigation. PMID:26315293

  17. Neuroprotective Actions of Neurosteroids

    PubMed Central

    Borowicz, Kinga K.; Piskorska, Barbara; Banach, Monika; Czuczwar, Stanislaw J.

    2011-01-01

    Neurosteroids were initially defined as steroid hormones locally synthesized within the nervous tissue. Subsequently, they were described as steroid hormone derivatives that devoid hormonal action but still affect neuronal excitability through modulation of ionotropic receptors. Neurosteroids are further subdivided into natural (produced in the brain) and synthetic. Some authors distinguish between hormonal and regular neurosteroids in the group of natural ones. The latter group, including hormone metabolites like allopregnanolone or tetrahydrodeoxycorticosterone, is devoid of hormonal activity. Both hormones and their derivatives share, however, most of the physiological functions. It is usually very difficult to distinguish the effects of hormones and their metabolites. All these substances may influence seizure phenomena and exhibit neuroprotective effects. Neuroprotection offered by steroid hormones may be realized in both genomic and non-genomic mechanisms and involve regulation of the pro- and anti-apoptotic factors expression, intracellular signaling pathways, neurotransmission, oxidative, and inflammatory processes. Since regular neurosteroids show no affinity for steroid receptors, they may act only in a non-genomic mode. Multiple studies have been conducted so far to show efficacy of neurosteroids in the treatment of the central and peripheral nervous system injury, ischemia, neurodegenerative diseases, or seizures. In this review we focused primarily on neurosteroid mechanisms of action and their role in the process of neurodegeneration. Most of the data refers to results obtained in experimental studies. However, it should be realized that knowledge about neuroactive steroids remains still incomplete and requires confirmation in clinical conditions. PMID:22649375

  18. Negative emotional outcomes attenuate sense of agency over voluntary actions.

    PubMed

    Yoshie, Michiko; Haggard, Patrick

    2013-10-21

    Sense of agency (SoA) refers to the feeling that one's voluntary actions produce external sensory events [1, 2]. Several psychological theories hypothesized links between SoA and affective evaluation [3-6]. For example, people tend to attribute positive outcomes to their own actions, perhaps reflecting high-level narrative processes that enhance self-esteem [3]. Here we provide the first evidence that such emotional modulations also involve changes in the low-level sensorimotor basis of agency. The intentional binding paradigm [1] was used to quantify the subjective temporal compression between a voluntary action and its sensory consequences, providing an implicit measure of SoA. Emotional valence of action outcomes was manipulated by following participants' key-press actions with negative or positive emotional vocalizations [7], or neutral sounds. We found that intentional binding was reduced for negative compared to positive or neutral outcomes. Discriminant analyses identified a change in time perception of both actions and their negative outcomes, demonstrating that the experience of action itself is subject to affective modulation. A small binding benefit was also found for positive action outcomes. Emotional modulation of SoA may contribute to regulating social behavior. Correctly tracking the valenced effects of one's voluntary actions on other people could underlie successful social interactions. PMID:24094850

  19. The minimalist grammar of action

    PubMed Central

    Pastra, Katerina; Aloimonos, Yiannis

    2012-01-01

    Language and action have been found to share a common neural basis and in particular a common ‘syntax’, an analogous hierarchical and compositional organization. While language structure analysis has led to the formulation of different grammatical formalisms and associated discriminative or generative computational models, the structure of action is still elusive and so are the related computational models. However, structuring action has important implications on action learning and generalization, in both human cognition research and computation. In this study, we present a biologically inspired generative grammar of action, which employs the structure-building operations and principles of Chomsky's Minimalist Programme as a reference model. In this grammar, action terminals combine hierarchically into temporal sequences of actions of increasing complexity; the actions are bound with the involved tools and affected objects and are governed by certain goals. We show, how the tool role and the affected-object role of an entity within an action drives the derivation of the action syntax in this grammar and controls recursion, merge and move, the latter being mechanisms that manifest themselves not only in human language, but in human action too. PMID:22106430

  20. Willed action and its impairments.

    PubMed

    Jahanshahi, M

    1998-09-01

    Actions are goal-directed behaviours that usually involve movem ent. There is evidence that intentional self-generated actions (willed actions) are controlled differently from routine, stereotyped actions that are externally triggered by environmental stimuli. We review evidence from investigations using positron emission tomography (PET), recordings of movement-related cortical potentials (MRCPs) or transcranial magnetic stimulation (TMS), and conclude that willed actions are controlled by a network of frontal cortical (dorsolateral prefrontal cortex, supplementary motor area, anterior cingulate) and subcortical (thalamus and basal ganglia) areas. We also consider evidence suggesting that some of the cognitive and motor deficits of patients with frontal lesions, Parkinson's disease, or schizophrenia as well as apathy and abulia and rarer phenomena such as primary obsessional slowness can be considered as reflecting im pairment of willed actions. We propose that the concept of a willed action system based on the frontostriatal circuits provides a useful framework for integrating the cognitive, motor, and motivational deficits found in these disorders. Problems remaining to be resolved include: identification of the component processes of willed actions; the specific and differential role played by each of the frontal cortical and subcortical areas in the control of willed actions; the specific mechanisms of impairm ent of willed actions in Parkinson's disease, schizophrenia, and frontal damage; and the precise role of the neurotransmitter dopamine in the willed action system. PMID:22448836

  1. Consciousness: individuated information in action.

    PubMed

    Jonkisz, Jakub

    2015-01-01

    Within theoretical and empirical enquiries, many different meanings associated with consciousness have appeared, leaving the term itself quite vague. This makes formulating an abstract and unifying version of the concept of consciousness - the main aim of this article -into an urgent theoretical imperative. It is argued that consciousness, characterized as dually accessible (cognized from the inside and the outside), hierarchically referential (semantically ordered), bodily determined (embedded in the working structures of an organism or conscious system), and useful in action (pragmatically functional), is a graded rather than an all-or-none phenomenon. A gradational approach, however, despite its explanatory advantages, can lead to some counterintuitive consequences and theoretical problems. In most such conceptions consciousness is extended globally (attached to primitive organisms or artificial systems), but also locally (connected to certain lower-level neuronal and bodily processes). For example, according to information integration theory (as introduced recently by Tononi and Koch, 2014), even such simple artificial systems as photodiodes possess miniscule amounts of consciousness. The major challenge for this article, then, is to establish reasonable, empirically justified constraints on how extended the range of a graded consciousness could be. It is argued that conscious systems are limited globally by the ability to individuate information (where individuated information is understood as evolutionarily embedded, socially altered, and private), whereas local limitations should be determined on the basis of a hypothesis about the action-oriented nature of the processes that select states of consciousness. Using these constraints, an abstract concept of consciousness is arrived at, hopefully contributing to a more unified state of play within consciousness studies itself. PMID:26283987

  2. Consciousness: individuated information in action

    PubMed Central

    Jonkisz, Jakub

    2015-01-01

    Within theoretical and empirical enquiries, many different meanings associated with consciousness have appeared, leaving the term itself quite vague. This makes formulating an abstract and unifying version of the concept of consciousness – the main aim of this article –into an urgent theoretical imperative. It is argued that consciousness, characterized as dually accessible (cognized from the inside and the outside), hierarchically referential (semantically ordered), bodily determined (embedded in the working structures of an organism or conscious system), and useful in action (pragmatically functional), is a graded rather than an all-or-none phenomenon. A gradational approach, however, despite its explanatory advantages, can lead to some counterintuitive consequences and theoretical problems. In most such conceptions consciousness is extended globally (attached to primitive organisms or artificial systems), but also locally (connected to certain lower-level neuronal and bodily processes). For example, according to information integration theory (as introduced recently by Tononi and Koch, 2014), even such simple artificial systems as photodiodes possess miniscule amounts of consciousness. The major challenge for this article, then, is to establish reasonable, empirically justified constraints on how extended the range of a graded consciousness could be. It is argued that conscious systems are limited globally by the ability to individuate information (where individuated information is understood as evolutionarily embedded, socially altered, and private), whereas local limitations should be determined on the basis of a hypothesis about the action-oriented nature of the processes that select states of consciousness. Using these constraints, an abstract concept of consciousness is arrived at, hopefully contributing to a more unified state of play within consciousness studies itself. PMID:26283987

  3. Corrective Action Plan for Corrective Action Unit 563: Septic Systems, Nevada Test Site, Nevada

    SciTech Connect

    NSTec Environmental Restoration

    2009-03-31

    This Corrective Action Plan (CAP) has been prepared for Corrective Action Unit (CAU) 563, Septic Systems, in accordance with the Federal Facility Agreement and Consent Order. CAU 563 consists of four Corrective Action Sites (CASs) located in Areas 3 and 12 of the Nevada Test Site. CAU 563 consists of the following CASs: CAS 03-04-02, Area 3 Subdock Septic Tank CAS 03-59-05, Area 3 Subdock Cesspool CAS 12-59-01, Drilling/Welding Shop Septic Tanks CAS 12-60-01, Drilling/Welding Shop Outfalls Site characterization activities were performed in 2007, and the results are presented in Appendix A of the CAU 563 Corrective Action Decision Document. The scope of work required to implement the recommended closure alternatives is summarized below. CAS 03-04-02, Area 3 Subdock Septic Tank, contains no contaminants of concern (COCs) above action levels. No further action is required for this site; however, as a best management practice (BMP), all aboveground features (e.g., riser pipes and bumper posts) will be removed, the septic tank will be removed, and all open pipe ends will be sealed with grout. CAS 03-59-05, Area 3 Subdock Cesspool, contains no COCs above action levels. No further action is required for this site; however, as a BMP, all aboveground features (e.g., riser pipes and bumper posts) will be removed, the cesspool will be abandoned by filling it with sand or native soil, and all open pipe ends will be sealed with grout. CAS 12-59-01, Drilling/Welding Shop Septic Tanks, will be clean closed by excavating approximately 4 cubic yards (yd3) of arsenic- and chromium-impacted soil. In addition, as a BMP, the liquid in the South Tank will be removed, the North Tank will be removed or filled with grout and left in place, the South Tank will be filled with grout and left in place, all open pipe ends will be sealed with grout or similar material, approximately 10 yd3 of chlordane-impacted soil will be excavated, and debris within the CAS boundary will be removed. CAS 12

  4. Testing fractional action cosmology

    NASA Astrophysics Data System (ADS)

    Shchigolev, V. K.

    2016-08-01

    The present work deals with a combined test of the so-called Fractional Action Cosmology (FAC) on the example of a specific model obtained by the author earlier. In this model, the effective cosmological term is proportional to the Hubble parameter squared through the so-called kinematic induction. The reason of studying this cosmological model could be explained by its ability to describe two periods of accelerated expansion, that is in agreement with the recent observations and the cosmological inflation paradigm. First of all, we put our model through the theoretical tests, which gives a general conception of the influence of the model parameters on its behavior. Then, we obtain some restrictions on the principal parameters of the model, including the fractional index, by means of the observational data. Finally, the cosmography parameters and the observational data compared to the theoretical predictions are presented both analytically and graphically.

  5. The Quench Action

    NASA Astrophysics Data System (ADS)

    Caux, Jean-Sébastien

    2016-06-01

    We give a pedagogical introduction to the methodology of the Quench Action, which is an effective representation for the calculation of time-dependent expectation values of physical operators following a generic out-of-equilibrium state preparation protocol (for example a quantum quench). The representation, originally introduced in Caux and Essler (2013 Phys. Rev. Lett. 110 257203), is founded on a mixture of exact data for overlaps together with variational reasonings. It is argued to be quite generally valid and thermodynamically exact for arbitrary times after the quench (from short times all the way up to the steady state), and applicable to a wide class of physically relevant observables. Here, we introduce the method and its language, give an overview of some recent results, suggest a roadmap and offer some perspectives on possible future research directions.

  6. Guam Energy Action Plan

    SciTech Connect

    Conrad, M. D.; Ness, J. E.

    2013-07-01

    Describes the four near-term strategies selected by the Guam Energy Task Force during action planning workshops conducted in March 2013, and outlines the steps being taken to implement those strategies. Each strategy addresses one of the energy sectors identified in the earlier Guam strategic energy plan as being an essential component of diversifying Guam's fuel sources and reducing fossil energy consumption 20% by 2020. The four energy strategies selected are: (1) expanding public outreach on energy efficiency and conservation, (2) establishing a demand-side management revolving loan program, (3) exploring waste-to-energy options, and (4) influencing the transportation sector via anti-idling legislation, vehicle registration fees, and electric vehicles.

  7. Cardiovascular actions of berberine.

    PubMed

    Lau, C W; Yao, X Q; Chen, Z Y; Ko, W H; Huang, Y

    2001-01-01

    Berberine, is an alkaloid from Hydrastis canadensis L., Chinese herb Huanglian, and many other plants. It is widely used in traditional Chinese medicine as an antimicrobial in the treatment of dysentery and infectious diarrhea. This manuscript describes cardiovascular effects of berberine and its derivatives, tetrahydroberberine and 8-oxoberberine. Berberine has positive inotropic, negative chronotropic, antiarrhythmic, and vasodilator properties. Both derivatives of berberine have antiarrhythmic activity. Some cardiovascular effects of berberine and its derivatives are attributed to the blockade of K+ channels (delayed rectifier and K(ATP)) and stimulation of Na+ -Ca(2+) exchanger. Berberine has been shown to prolong the duration of ventricular action potential. Its vasodilator activity has been attributed to multiple cellular mechanisms. The cardiovascular effects of berberine suggest its possible clinical usefulness in the treatment of arrhythmias and/or heart failure. PMID:11607041

  8. Everyday robotic action: lessons from human action control

    PubMed Central

    de Kleijn, Roy; Kachergis, George; Hommel, Bernhard

    2014-01-01

    Robots are increasingly capable of performing everyday human activities such as cooking, cleaning, and doing the laundry. This requires the real-time planning and execution of complex, temporally extended sequential actions under high degrees of uncertainty, which provides many challenges to traditional approaches to robot action control. We argue that important lessons in this respect can be learned from research on human action control. We provide a brief overview of available psychological insights into this issue and focus on four principles that we think could be particularly beneficial for robot control: the integration of symbolic and subsymbolic planning of action sequences, the integration of feedforward and feedback control, the clustering of complex actions into subcomponents, and the contextualization of action-control structures through goal representations. PMID:24672474

  9. Proactive action preparation: seeing action preparation as a continuous and proactive process.

    PubMed

    Pezzulo, Giovanni; Ognibene, Dimitri

    2012-07-01

    In this paper, we aim to elucidate the processes that occur during action preparation from both a conceptual and a computational point of view. We first introduce the traditional, serial model of goal-directed action and discuss from a computational viewpoint its subprocesses occurring during the two phases of covert action preparation and overt motor control. Then, we discuss recent evidence indicating that these subprocesses are highly intertwined at representational and neural levels, which undermines the validity of the serial model and points instead to a parallel model of action specification and selection. Within the parallel view, we analyze the case of delayed choice, arguing that action preparation can be proactive, and preparatory processes can take place even before decisions are made. Specifically, we discuss how prior knowledge and prospective abilities can be used to maximize utility even before deciding what to do. To support our view, we present a computational implementation of (an approximated version of) proactive action preparation, showing its advantages in a simulated tennis-like scenario. PMID:22643383

  10. [Health promotion actions in a prison environment].

    PubMed

    Dechet, Fabienne

    2012-01-01

    Prisoners must be able to benefit from the same level of healthcare as the general population. With this objective in mind, nurses from the consultations and outpatient care unit (UCSA) of La Santé prison in Paris take part in the development of health promotion actions. Active participation methods are favoured in order to encourage prisoners to become involved in protecting their health. PMID:22489423

  11. Ensuring preparedness: Testing an emergency action plan

    SciTech Connect

    Gibson, J.Z.; Hildebrand, L.G. )

    1992-12-01

    For dam owners, having a plan for responding to dam failure is not enough. To ensure that operating personnel and local authorities and emergency response agencies are prepared, the plan needs to be tested periodically. This article describes how Washington Water Power tested its emergency action plan at its Cabinet Gorge project in September, 1990. The objectives, details, and critique of the test are described, as is FERC's five-level exercise testing program.

  12. Beneficial action of resveratrol: How and why?

    PubMed

    Diaz-Gerevini, Gustavo Tomas; Repossi, Gaston; Dain, Alejandro; Tarres, María Cristina; Das, Undurti Narasimha; Eynard, Aldo Renato

    2016-02-01

    Flavonoid resveratrol modulates the transcription factor NF-κB; inhibits the cytochrome P450 isoenzyme CYP1 A1; suppresses the expression and activity of cyclooxygenase enzymes; and modulates Fas/Fas-ligand-mediated apoptosis, p53, mammalian target of rapamycin, and cyclins and various phosphodiesterases. This increases the cytosolic cAMP that activates Epac1/CaMKKβ/AMPK/SIRT1/PGC-1α pathway, which in turn facilitates increased oxidation of fatty acids, mitochondrial biogenesis, mitochondrial respiration, and gluconeogenesis. Resveratrol triggers apoptosis of activated T cells and suppresses tumor necrosis factor-α, interluekin-17 (IL-17), and other proinflammatory molecules, and thus is of benefit in autoimmune diseases. In addition, resveratrol inhibits expression of hypoxia-inducible factor-1α and vascular endothelial growth factor, explaining its effective action against cancer. Brain-derived neurotrophic factor (BDNF) that is involved in the pathogenesis of obesity, type 2 diabetes mellitus, and metabolic syndrome is also altered in depression, schizophrenia, bipolar disorder, and autism. We noted that BDNF protects against cytotoxic actions of alloxan, streptozotocin, and benzo(a)pyrene. Resveratrol prevents bisphenol A-induced autism, type 2 diabetes mellitus, and metabolic syndrome, suggesting that it may augment BDNF synthesis and action. We also observed that BDNF levels are low in type 2 diabetes mellitus and that BDNF enhances production of antiinflammatory lipid, lipoxin A4, whose levels are low in diabetes mellitus. Thus, resveratrol may augment production of lipoxin A4. Resveratrol alters gut microbiota and influences stem cell proliferation and differentiation. These pleiotropic actions of resveratrol may explain the multitude of its actions and benefits. PMID:26706021

  13. On "action language" in psychoanalysis.

    PubMed

    Calogeras, R C; Alston, T M

    1980-10-01

    The main tenets of action language are summarized in an attempt to discern the direction in which psychoanalysis might go if action language becomes the "new metapsychology." The principal roots of action language are traced to the different linguistic/language and personality-and-culture models of anthropology and to the neobehaviorist currents of academic psychology. The authors' findings support the hypothesis that action language is a form os psychoanalytic behaviorism having idealism, logical positivism, and radical empiricism as its philosophical underpinnings. Its adoption would confound the entire motivational aspect of psychoanalysis. Specifically, the authors suggest that action language falls under the aegis of Wittgenstein's family of language games. When the action language game is said to be brought to a successful resolution, the language game disappears and, supposedly, so do the patient's conflicts. PMID:7422749

  14. 22 CFR 223.11 - Appropriate action.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Appropriate action. 223.11 Section 223.11...-EMPLOYMENT RESTRICTIONS § 223.11 Appropriate action. The Administrator may take appropriate action in the... action....

  15. Representing actions through their sound.

    PubMed

    Aglioti, Salvatore M; Pazzaglia, Mariella

    2010-10-01

    Since the discovery of 'mirror neurons' in the monkey premotor and parietal cortex, an increasing body of evidence in animals and humans alike has supported the notion of the inextricable link between action execution and action perception. Although research originally focused on the relationship between performed and viewed actions, more recent studies highlight the importance of representing the actions of others through audition. In the first part of this article, we discuss animal studies, which provide direct evidence that action is inherently linked to multi-sensory cues, as well as the studies carried out on healthy subjects by using state-of-the-art cognitive neuroscience techniques such as functional magnetic resonance imaging (fMRI), event-related potentials (ERP), magnetoencephalography (MEG), and transcranial magnetic stimulation (TMS). In the second section, we review the lesion analysis studies in brain-damaged patients demonstrating the link between 'resonant' fronto-parieto-temporal networks and the ability to represent an action by hearing its sound. Moreover, we examine the evidence in favour of somatotopy as a possible representational rule underlying the auditory mapping of actions and consider the links between language and audio-motor action mapping. We conclude with a discussion of some outstanding questions for future research on the link between actions and the sounds they produce. PMID:20602092

  16. Perception of Individual and Joint Action in Infants and Adults

    PubMed Central

    Keitel, Anne; Prinz, Wolfgang; Daum, Moritz M.

    2014-01-01

    Infants and adults frequently observe actions performed jointly by more than one person. Research in action perception, however, has focused largely on actions performed by an individual person. Here, we explore how 9- and 12-month-old infants and adults perceive a block-stacking action performed by either one agent (individual condition) or two agents (joint condition). We used eye tracking to measure the latency of participants’ gaze shifts towards action goals. Adults anticipated goals in both conditions significantly faster than infants, and their gaze latencies did not differ between conditions. By contrast, infants showed faster anticipation of goals in the individual condition than in the joint condition. This difference was more pronounced in 9-month-olds. Further analyses of fixations examined the role of visual attention in action perception. These findings are cautiously interpreted in terms of low-level processing in infants and higher-level processing in adults. More precisely, our results suggest that adults are able to infer the overarching joint goal of two agents, whereas infants are not yet able to do so and might rely primarily on visual cues to infer the respective sub-goals. In conclusion, our findings indicate that the perception of joint action in infants develops differentially from that of individual action. PMID:25202914

  17. Numbers in Action

    PubMed Central

    Rugani, Rosa; Sartori, Luisa

    2016-01-01

    Humans show a remarkable tendency to describe and think of numbers as being placed on a mental number line (MNL), with smaller numbers located on the left and larger ones on the right. Faster responses to small numbers are indeed performed on the left side of space, while responses to large numbers are facilitated on the right side of space (spatial-numerical association of response codes, SNARC effect). This phenomenon is considered the experimental demonstration of the MNL and has been extensively replicated throughout a variety of paradigms. Nevertheless, the majority of previous literature has mainly investigated this effect by means of response times and accuracy, whereas studies considering more subtle and automatic measures such as kinematic parameters are rare (e.g., in a reaching-to-grasp movement, the grip aperture is enlarged in responding to larger numbers than in responding to small numbers). In this brief review we suggest that numerical magnitude can also affect the what and how of action execution (i.e., temporal and spatial components of movement). This evidence could have large implications in the strongly debated issue concerning the effect of experience and culture on the orientation of MNL. PMID:27524965

  18. Pharmacogenetics of FSH action

    PubMed Central

    Laan, Maris; Grigorova, Marina; Huhtaniemi, Ilpo T.

    2012-01-01

    Purpose of the review To review the current knowledge of genetic variants in the two genes affecting the individual responsiveness to follicle-stimulating hormone (FSH) action—the FSH beta-subunit (FSHB) and the FSH receptor (FSHR), as well as the pharmacogenetic ramifications of the findings. Recent findings Four common variants in FSHB/FSHR were shown to exhibit significant effect on FSH action: linked FSHR variants Thr307Ala and Asn680Ser determining common receptorisoforms, andgene expression affecting polymorphisms FSHR –29G/A and FSHB–211G/T. In women, the FSHR Thr307Ala/Asn680Ser polymorphisms show consistent predictive value for estimating the most optimal rFSH dosage in controlled ovarian hyperstimulation(COH).The same variants exhibit a potential for the pharmacogenetic assessment of the treatment ofPCOS. The FSHR–29G/A variant was also shown to contribute to ovarian response to COH. Pilot studies have suggestedthe FSHB–211TT-homozygous oligozoospermicmen with genetically determined low concentration of FSH, as potentially the best responders to FSH treatment; furthermore, modulation of this response by FSHR polymorphisms is possible. Summary Genetic variants in FSHB/FSHRexhibit a potential for pharmacogenetic applications in selecting appropriate treatment options (timing and dosage) in male and female conditions requiring or benefitting from FSH therapy. PMID:22499219

  19. Nonclassical Vitamin D Action

    PubMed Central

    Zittermann, Armin; Gummert, Jan F.

    2010-01-01

    It is becoming increasingly clear that vitamin D has a broad range of actions in the human body. Besides its well-known effects on calcium/phosphate homeostasis, vitamin D influences muscle function, cardiovascular homeostasis, nervous function, and the immune response. Vitamin D deficiency/insufficiency has been associated with muscle weakness and a high incidence of various chronic diseases such as cardiovascular disease, cancer, multiple sclerosis, and type 1 and 2 diabetes. Most importantly, low vitamin D status has been found to be an independent predictor of all-cause mortality. Several recent randomized controlled trials support the assumption that vitamin D can improve muscle strength, glucose homeostasis, and cardiovascular risk markers. In addition, vitamin D may reduce cancer incidence and elevated blood pressure. Since the prevalence of vitamin D deficiency/insufficiency is high throughout the world, there is a need to improve vitamin D status in the general adult population. However, the currently recommended daily vitamin D intake of 5-15 µg is too low to achieve an adequate vitamin D status in individuals with only modest skin synthesis. Thus, there is a need to recommend a vitamin D intake that is effective for achieving adequate circulating 25-hydroxyvitamin D concentrations (>75 nmol/L). PMID:22254030

  20. Less chalk more action

    NASA Astrophysics Data System (ADS)

    Mitriceski Andelkovic, Bojana; Jovic, Sladjana

    2016-04-01

    Less chalk more action Education should not be a mechanical system that operates according to the principles of the orders and implementation. Education should respect the basic laws of the develop and progress. Curiosity is the engine of achievement and children spontaneously and happily learn only if they get interested, if teacher wake up and stimulate their creativity and individuality. We would like to present classes that are realized as thematic teaching with several subjects involved: chemistry, geography, math, art and biology. Classes were organized for students at age from 10 to 13 years, every month during autumn and winter 2015. Better students identified themselves as teachers and presented peer education .Teachers were monitoring the process of teaching and help to develop links between younger and older students, where older students were educators to younger students. Also one student with special needs was involved in this activities and was supported by other students during the workshops The benefit from this project will be represented with evaluation marks. Evaluation table shows that group of ten students(age 10 to13 years) which are selected in October as children with lack of motivation for learning, got better marks, at the end of January , then they had it in the beginning of the semester.

  1. Mobilizing grassroots action.

    PubMed

    1995-01-01

    Zero Population Growth, Inc. (ZPG), was very busy in 1994 spreading its message about the dangers of rapid population growth. ZPG's Field and Outreach Program is vital to the success of the organization. Organization activists staffed tables at more than 170 events in 1994, while the Speakers Network gave 159 presentations. ZPG was represented on Earth Day, World Population Day, during World Population Awareness Week, and at Cairo town meetings, as well as at the HORDE rock festival and the 25th anniversary of the Woodstock Music Festival. Campus contacts developed at these latter two concerts formed the basic for ZPG's Campus Outreach Project. In 1994, the Field department focused upon the International Conference on Population and Development to be held in Cairo, Egypt. ZPG encouraged people to get involved in conference preparations by helping to plan and implement town meetings in eleven major US cities. Members were contacted by ZPG via flyers and phone calls about meetings in their areas. ZPG activists and chapters then provided leadership for many of the meetings which drew thousands of participants and were widely praised by national leaders. Throughout 1994, ZPG's 21 chapters provided members with a vehicle for collective action and a source of information about the population conference, population growth, and wasteful consumption. Chapter activists also helped secure the signatures of thousands of people on Population Priority Petitions; the final list of names was delivered to US Vice President Al Gore in November. PMID:12289955

  2. Affirmative Action Plan, October 1991--September 1992

    SciTech Connect

    Not Available

    1991-10-01

    This report documents Reynolds Electrical Engineering Co., Inc., analysis of all major job groups with explanations if minorities and females are underutilized in any one or more job group. Goals and timetables have been developed and good faith efforts are directed to correct any deficiencies. In addition, Affirmative Action Plans for the Handicapped, Vietnam Era Veterans, and Disabled Veterans are included which set forth policies, practices, and procedures in accordance with Department of Labor regulations. All personnel decisions are made at the Company level. Decisions regarding the General Manager or Deputy General Manager are made at the corporate level.

  3. From Movements to Actions: Two Mechanisms for Learning Action Sequences

    ERIC Educational Resources Information Center

    Endress, Ansgar D.; Wood, Justin N.

    2011-01-01

    When other individuals move, we interpret their movements as discrete, hierarchically-organized, goal-directed actions. However, the mechanisms that integrate visible movement features into actions are poorly understood. Here, we consider two sequence learning mechanisms--transitional probability-based (TP) and position-based encoding…

  4. The Development of Action Planning in a Joint Action Context

    ERIC Educational Resources Information Center

    Paulus, Markus

    2016-01-01

    The ability to act jointly with another person is a fundamental requirement for participation in social life. The current study examines the development of action planning in a joint action context. In 4 experiments, 3-, 5-, and 7-year-old children as well as a group of adults (n = 196) interacted with another person to operate a novel apparatus.…

  5. Action selection and action value in frontal-striatal circuits

    PubMed Central

    Seo, Moonsang; Lee, Eunjeong; Averbeck, Bruno B.

    2012-01-01

    Summary The role that frontal-striatal circuits play in normal behavior remains unclear. Two of the leading hypotheses suggest that these circuits are important for action selection or reinforcement learning. To examine these hypotheses we carried out an experiment in which monkeys had to select actions in two different task conditions. In the first (random) condition actions were selected on the basis of perceptual inference. In the second (fixed) condition the animals used reinforcement from previous trials to select actions. Examination of neural activity showed that the representation of the selected action was stronger in lateral prefrontal cortex (lPFC), and occurred earlier in the lPFC than it did in the dorsal striatum (dSTR). In contrast to this, the representation of action values, in both the random and fixed conditions was stronger in the dSTR. Thus, the dSTR contains an enriched representation of action value, but it followed frontal cortex in action selection. PMID:22681697

  6. Action verbal fluency in Parkinson's patients.

    PubMed

    Rodrigues, Inês Tello; Ferreira, Joaquim J; Coelho, Miguel; Rosa, Mario M; Castro-Caldas, Alexandre

    2015-06-01

    We compared the performance of 31 non-demented Parkinson's disease (PD) patients to 61 healthy controls in an action verbal fluency task. Semantic and phonemic fluencies, cognitive impairment and behavioural dysfunction were also assessed. The mean disease duration of PD was 9.8 years (standard deviation (SD) = 6.13). There were no age (U = 899.5, p = 0.616), gender(chi-square = 0.00, p = 1.00) or literacy (U = 956, p = 0.96) differences between the two groups. A significant difference was observed between the two groups in the action verbal fluency task (U = 406.5, p < 0.01) that was not found in the other fluency tasks. The education level was the only biographical variable that influenced the action (verb) fluency outcomes, irrespective of disease duration. Our findings suggest a correlation between the disease mechanisms in PD and a specific verb deficit, support the validity of the action (verb) fluency as an executive function measure and suggest that this task provides unique information not captured with traditional executive function tasks. PMID:26083889

  7. Triglyceride level

    MedlinePlus

    ... may also cause swelling of your pancreas (called pancreatitis). The triglyceride level is usually included in a ... lower triglyceride levels may be used to prevent pancreatitis for levels above 500 mg/dL Low triglyceride ...

  8. The Non-Genomic Actions of Vitamin D

    PubMed Central

    Hii, Charles S; Ferrante, Antonio

    2016-01-01

    Since its discovery in 1920, a great deal of effort has gone into investigating the physiological actions of vitamin D and the impact its deficiency has on human health. Despite this intense interest, there is still disagreement on what constitutes the lower boundary of adequacy and on the Recommended Dietary Allowance. There has also been a major push to elucidate the biochemistry of vitamin D, its metabolic pathways and the mechanisms that mediate its action. Originally thought to act by altering the expression of target genes, it was realized in the mid-1980s that some of the actions of vitamin D were too rapid to be accounted for by changes at the genomic level. These rapid non-genomic actions have attracted as much interest as the genomic actions and they have spawned additional questions in an already busy field. This mini-review attempts to summarise the in vitro and in vivo work that has been conducted to characterise the rapid non-genomic actions, the mechanisms that give rise to these properties and the roles that these play in the overall action of vitamin D at the cellular level. Understanding the effects of vitamin D at the cellular level should enable the design of elegant human studies to extract the full potential of vitamin D to benefit human health. PMID:26950144

  9. Manual on Political Action.

    ERIC Educational Resources Information Center

    Schakel, Minnekus

    This guide offers teachers and senior high school students the simple facts of how he can make a difference in the operation of the two-party system in the United States at the precinct level. It also attempts to show that students, teachers, the school curriculum, and our American political structure definitely need large numbers of high school…

  10. Volatile organic compound remedial action project

    SciTech Connect

    1991-12-01

    This Environmental Assessment (EA) reviews a proposed project that is planned to reduce the levels of volatile organic compound (VOC) contaminants present in the Mound domestic water supply. The potable and industrial process water supply for Mound is presently obtained from a shallow aquifer via on-site production wells. The present levels of VOCs in the water supply drawn from the on-site wells are below the maximum contaminant levels (MCLs) permissible for drinking water under Safe Drinking Water Act (SDWA; 40 CFR 141); however, Mound has determined that remedial measures should be taken to further reduce the VOC levels. The proposed project action is the reduction of the VOC levels in the water supply using packed tower aeration (PTA). This document is intended to satisfy the requirements of the National Environmental Policy Act (NEPA) of 1969 and associated Council on Environmental Quality regulations (40 CFR parts 1500 through 1508) as implemented through U.S. Department of Energy (DOE) Order 5440.1D and supporting DOE NEPA Guidelines (52 FR 47662), as amended (54 FR 12474; 55 FR 37174), and as modified by the Secretary of Energy Notice (SEN) 15-90 and associated guidance. As required, this EA provides sufficient information on the probable environmental impacts of the proposed action and alternatives to support a DOE decision either to prepare an Environmental Impact Statement (EIS) or issue a Finding of No Significant Impact (FONSI).

  11. 24 CFR 984.201 - Action Plan.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 4 2014-04-01 2014-04-01 false Action Plan. 984.201 Section 984... § 984.201 Action Plan. (a) Requirement for Action Plan. A PHA must have a HUD-approved Action Plan that... program is a mandatory or voluntary program. (b) Development of Action Plan. The Action Plan shall...

  12. 24 CFR 984.201 - Action Plan.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Action Plan. 984.201 Section 984... § 984.201 Action Plan. (a) Requirement for Action Plan. A PHA must have a HUD-approved Action Plan that... program is a mandatory or voluntary program. (b) Development of Action Plan. The Action Plan shall...

  13. 40 CFR 66.81 - Final action.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Final action. 66.81 Section 66.81... COLLECTION OF NONCOMPLIANCE PENALTIES BY EPA Final Action § 66.81 Final action. (a) A final Agency action... State action pursuant to part 67. (b) The actions listed in paragraph (a) of this section...

  14. 40 CFR 265.303 - Response actions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....301(a) must develop and keep on site until closure of the facility a response action plan. The response action plan must set forth the actions to be taken if the action leakage rate has been exceeded. At a minimum, the response action plan must describe the actions specified in paragraph (b) of...

  15. 40 CFR 264.304 - Response actions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) must have an approved response action plan before receipt of waste. The response action plan must set forth the actions to be taken if the action leakage rate has been exceeded. At a minimum, the response action plan must describe the actions specified in paragraph (b) of this section. (b) If the flow...

  16. 40 CFR 265.259 - Response actions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... § 265.254 must develop and keep on-site until closure of the facility a response action plan. The response action plan must set forth the actions to be taken if the action leakage rate has been exceeded. At a minimum, the response action plan must describe the actions specified in paragraph (b) of...

  17. 40 CFR 264.223 - Response actions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... § 264.221 (c) or (d) must have an approved response action plan before receipt of waste. The response action plan must set forth the actions to be taken if the action leakage rate has been exceeded. At a minimum, the response action plan must describe the actions specified in paragraph (b) of this section....

  18. 40 CFR 265.259 - Response actions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... § 265.254 must develop and keep on-site until closure of the facility a response action plan. The response action plan must set forth the actions to be taken if the action leakage rate has been exceeded. At a minimum, the response action plan must describe the actions specified in paragraph (b) of...

  19. 40 CFR 265.259 - Response actions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... § 265.254 must develop and keep on-site until closure of the facility a response action plan. The response action plan must set forth the actions to be taken if the action leakage rate has been exceeded. At a minimum, the response action plan must describe the actions specified in paragraph (b) of...

  20. 40 CFR 264.253 - Response actions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) or (d) must have an approved response action plan before receipt of waste. The response action plan must set forth the actions to be taken if the action leakage rate has been exceeded. At a minimum, the response action plan must describe the actions specified in paragraph (b) of this section. (b) If the...

  1. 40 CFR 265.259 - Response actions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... § 265.254 must develop and keep on-site until closure of the facility a response action plan. The response action plan must set forth the actions to be taken if the action leakage rate has been exceeded. At a minimum, the response action plan must describe the actions specified in paragraph (b) of...

  2. 40 CFR 264.223 - Response actions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... § 264.221 (c) or (d) must have an approved response action plan before receipt of waste. The response action plan must set forth the actions to be taken if the action leakage rate has been exceeded. At a minimum, the response action plan must describe the actions specified in paragraph (b) of this section....

  3. 40 CFR 264.304 - Response actions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) must have an approved response action plan before receipt of waste. The response action plan must set forth the actions to be taken if the action leakage rate has been exceeded. At a minimum, the response action plan must describe the actions specified in paragraph (b) of this section. (b) If the flow...

  4. 40 CFR 264.304 - Response actions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) must have an approved response action plan before receipt of waste. The response action plan must set forth the actions to be taken if the action leakage rate has been exceeded. At a minimum, the response action plan must describe the actions specified in paragraph (b) of this section. (b) If the flow...

  5. 40 CFR 265.224 - Response actions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... action plan. The response action plan must set forth the actions to be taken if the action leakage rate has been exceeded. At a minimum, the response action plan must describe the actions specified in paragraph (b) of this section. (b) If the flow rate into the leak detection system exceeds the...

  6. 40 CFR 264.223 - Response actions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... § 264.221 (c) or (d) must have an approved response action plan before receipt of waste. The response action plan must set forth the actions to be taken if the action leakage rate has been exceeded. At a minimum, the response action plan must describe the actions specified in paragraph (b) of this section....

  7. 40 CFR 265.224 - Response actions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... action plan. The response action plan must set forth the actions to be taken if the action leakage rate has been exceeded. At a minimum, the response action plan must describe the actions specified in paragraph (b) of this section. (b) If the flow rate into the leak detection system exceeds the...

  8. 40 CFR 265.224 - Response actions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... action plan. The response action plan must set forth the actions to be taken if the action leakage rate has been exceeded. At a minimum, the response action plan must describe the actions specified in paragraph (b) of this section. (b) If the flow rate into the leak detection system exceeds the...

  9. 40 CFR 265.259 - Response actions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... § 265.254 must develop and keep on-site until closure of the facility a response action plan. The response action plan must set forth the actions to be taken if the action leakage rate has been exceeded. At a minimum, the response action plan must describe the actions specified in paragraph (b) of...

  10. 40 CFR 264.304 - Response actions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) must have an approved response action plan before receipt of waste. The response action plan must set forth the actions to be taken if the action leakage rate has been exceeded. At a minimum, the response action plan must describe the actions specified in paragraph (b) of this section. (b) If the flow...

  11. 40 CFR 264.304 - Response actions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) must have an approved response action plan before receipt of waste. The response action plan must set forth the actions to be taken if the action leakage rate has been exceeded. At a minimum, the response action plan must describe the actions specified in paragraph (b) of this section. (b) If the flow...

  12. Bodily action penetrates affective perception

    PubMed Central

    Rigutti, Sara; Gerbino, Walter

    2016-01-01

    Fantoni & Gerbino (2014) showed that subtle postural shifts associated with reaching can have a strong hedonic impact and affect how actors experience facial expressions of emotion. Using a novel Motor Action Mood Induction Procedure (MAMIP), they found consistent congruency effects in participants who performed a facial emotion identification task after a sequence of visually-guided reaches: a face perceived as neutral in a baseline condition appeared slightly happy after comfortable actions and slightly angry after uncomfortable actions. However, skeptics about the penetrability of perception (Zeimbekis & Raftopoulos, 2015) would consider such evidence insufficient to demonstrate that observer’s internal states induced by action comfort/discomfort affect perception in a top-down fashion. The action-modulated mood might have produced a back-end memory effect capable of affecting post-perceptual and decision processing, but not front-end perception. Here, we present evidence that performing a facial emotion detection (not identification) task after MAMIP exhibits systematic mood-congruent sensitivity changes, rather than response bias changes attributable to cognitive set shifts; i.e., we show that observer’s internal states induced by bodily action can modulate affective perception. The detection threshold for happiness was lower after fifty comfortable than uncomfortable reaches; while the detection threshold for anger was lower after fifty uncomfortable than comfortable reaches. Action valence induced an overall sensitivity improvement in detecting subtle variations of congruent facial expressions (happiness after positive comfortable actions, anger after negative uncomfortable actions), in the absence of significant response bias shifts. Notably, both comfortable and uncomfortable reaches impact sensitivity in an approximately symmetric way relative to a baseline inaction condition. All of these constitute compelling evidence of a genuine top-down effect on

  13. A Toolkit for Action Research

    ERIC Educational Resources Information Center

    Alber, Sandra M.

    2010-01-01

    This book facilitates the completion of action research studies by providing a series of tasks that guide action researchers from the beginning of a project and selecting a topic for study, to completion of the project and editing final reports. All too often, students and practicing professionals in professional development schools are…

  14. Affirmative Action, or Reverse Discrimination?

    ERIC Educational Resources Information Center

    Dansby, Ike

    1996-01-01

    Determines the impact of affirmative action programs in response to charges that they are policies of reverse discrimination. Reviewing affirmative action programs submitted by Michigan State departments, researchers determined no reverse discrimination was apparent based on low numbers of reverse discrimination complaints filed by whites. (GR)

  15. Action Research Empowers School Librarians

    ERIC Educational Resources Information Center

    Robins, Jennifer

    2015-01-01

    Successful school library programs occur through careful planning and reflection. This reflective process is improved when it is applied in a systematic way through action research. The action research described in this paper enabled school librarians to reflect based on evidence, using data they had collected. This study presents examples of the…

  16. Action Research: Theory and Applications

    ERIC Educational Resources Information Center

    Jefferson, Renée N.

    2014-01-01

    Action research as a methodology is suitable for use within academic library settings. Its theoretical foundations are located in several disciplines and its applications span across many professions. In this article, an overview of the theoretical beginnings and evolution of action research is presented. Approaches generally used in conducting an…

  17. Automatic Imitation of Intransitive Actions

    ERIC Educational Resources Information Center

    Press, Clare; Bird, Geoffrey; Walsh, Eamonn; Heyes, Cecilia

    2008-01-01

    Previous research has indicated a potential discontinuity between monkey and human ventral premotor-parietal mirror systems, namely that monkey mirror systems process only transitive (object-directed) actions, whereas human mirror systems may also process intransitive (non-object-directed) actions. The present study investigated this discontinuity…

  18. Community Action for Environmental Quality.

    ERIC Educational Resources Information Center

    Citizens Advisory Committee on Environmental Quality.

    For citizens who want to participate in practical action to make their communities better places for living, this guide considers numerous approaches for community involvement. It stresses not only comprehensive planning but also the importance of getting action started. A rough order of business is suggested. First, considered are the various…

  19. Technology assessment and citizen action

    NASA Technical Reports Server (NTRS)

    Mottur, E. R.

    1975-01-01

    Citizen participation in the nation's total social, political, economic decisionmaking processes was studied. Impediments are discussed which prevent citizens from taking effective assessment action; these include finance, organization and motivation, and information. The proposal for establishing citizens assessment associations is considered along with implications of citizen assessment action.

  20. Action Research and Teacher Leadership

    ERIC Educational Resources Information Center

    Smeets, Karel; Ponte, Petra

    2009-01-01

    The present article reports on a case study into the influence and impact of action research carried out by teachers in a special school. The action research was an important component of the two-year, post-initial, in-service course in special educational needs, provided by Fontys University of Applied Sciences, Department of Inclusive and…

  1. Thought and Action in Education

    ERIC Educational Resources Information Center

    Rømer, Thomas Aastrup

    2015-01-01

    In much theory there is a tendency to place thought above action, or the opposite, action over thought. The consequence of the first option is that philosophy or scientific evidence gains the upper hand in educational thinking. The consequence of the second view is that pragmatism and relativism become the dominant features. This article discusses…

  2. Action Learning in the BBC

    ERIC Educational Resources Information Center

    Felix, Eversley; Keevill, Joan

    2008-01-01

    This account tells the story of the development of an action learning culture in the BBC between 2002 and 2007. From its early beginnings as a sporadic, unsystematic intervention with a small number of leaders scattered throughout the organisation, action learning has now become embedded in our approach to the way we develop our leaders. In this…

  3. Integrating CHAT and Action Research

    ERIC Educational Resources Information Center

    Wells, Gordon

    2011-01-01

    The question as to how action research (AR) is related to cultural-historical activity theory (CHAT) is not answerable in categorical terms. Both CHAT and AR have been variously interpreted and much depends on the individual biographies of those who pronounce on their relationship. The aim of this paper is to show how action research, conducted…

  4. Mode of Action of Glyphosate

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Although glyphosate is the most used and studied herbicide in the world, the available information is not enough to fully understand its mode of action. The molecular site of action of glyphosate is the enzyme 5-enolpyruvlyshikimate-3-phosphate synthase (EPSPS). It is the only known compound that ...

  5. Action Understanding as Inverse Planning

    ERIC Educational Resources Information Center

    Baker, Chris L.; Saxe, Rebecca; Tenenbaum, Joshua B.

    2009-01-01

    Humans are adept at inferring the mental states underlying other agents' actions, such as goals, beliefs, desires, emotions and other thoughts. We propose a computational framework based on Bayesian inverse planning for modeling human action understanding. The framework represents an intuitive theory of intentional agents' behavior based on the…

  6. Philosophy, Methodology and Action Research

    ERIC Educational Resources Information Center

    Carr, Wilfred

    2006-01-01

    The aim of this paper is to examine the role of methodology in action research. It begins by showing how, as a form of inquiry concerned with the development of practice, action research is nothing other than a modern 20th century manifestation of the pre-modern tradition of practical philosophy. It then draws in Gadamer's powerful vindication of…

  7. Taking Action with Teacher Research.

    ERIC Educational Resources Information Center

    Meyers, Ellen; Rust, Frances O'Connell

    This collection of papers presents examples of teacher research in action. Each study grew out of teachers' questions regarding the implementation of some aspect of education policy in their schools and classrooms. After "Introduction" (Frances O'Connell Rust and Ellen Meyers), the eight papers focus on: (1) "How We Do Action Research" (Frances…

  8. Poised on the Precipice: The Michigan Cases and Affirmative Action in Higher Education.

    ERIC Educational Resources Information Center

    Springer, Ann D.

    This review comments on the recent class action suits in Michigan related to affirmative action and college admission. It reviews related cases and the legal basis for the Supreme Court decisions that are expected to have widespread effects. Affirmative action plans exist at all levels of government and business, and a broad ruling invalidating…

  9. Jotting Down Notes or Preparing for the Future? Action Identification and Academic Performance

    ERIC Educational Resources Information Center

    Mange, Jessica; Senemeaud, Cecile; Michinov, Nicolas

    2013-01-01

    The purpose of the present study was both to extend the performance optimality hypothesis of action identification theory to the realm of education and to examine the indirect role of action identification levels and action maintenance difficulty on the relationship between initial and final performance. Results demonstrated that students' final…

  10. The Cognitive Representation of Intending Not to Act: Evidence for Specific Non-Action-Effect Binding

    ERIC Educational Resources Information Center

    Kuhn, Simone; Brass, Marcel

    2010-01-01

    The question how we represent voluntary action on a cognitive level has recently become of increasing interest to researchers studying motor control. However, so far it has been neglected how we represent the voluntary omission of an action. In our attempt to investigate the representation of voluntary non-actions we demonstrated binding effects…

  11. The development of action planning in a joint action context.

    PubMed

    Paulus, Markus

    2016-07-01

    The ability to act jointly with another person is a fundamental requirement for participation in social life. The current study examines the development of action planning in a joint action context. In 4 experiments, 3-, 5-, and 7-year-old children as well as a group of adults (n = 196) interacted with another person to operate a novel apparatus. Their task was to hand the experimenter a tool with which she could activate 1 of 2 different effects on the apparatus. The elicitation of each effect required participants to grasp and insert the tool in a particular orientation. We assessed whether participants planned their grasping and reaching action in such a way that it enabled the partner to efficiently handle the tool, that is, anticipating the final end state of the joint activity. We found that 3-year-old children did not adjust their behavior to accommodate the other's action and that they did not increase their performance over multiple trials. Five- and 7-year-old children initially showed a tendency to plan their action in an egocentric manner (i.e., showed a form of egocentrism), but improved their joint action performance over time. Adult participants demonstrated joint action planning from the beginning. Interestingly, 3- and 5-year-old children were able to plan their grasp efficiently when acting alone on the apparatus. Yet, having first-hand experience with the task before acting with a partner did not facilitate performance in the joint action task for younger children. Overall, the study informs current approaches on the psychological basis and ontogenetic origins of joint action in childhood. (PsycINFO Database Record PMID:27337512

  12. Conscious vision for action versus unconscious vision for action?

    PubMed

    Brogaard, Berit

    2011-08-01

    David Milner and Melvyn Goodale's dissociation hypothesis is commonly taken to state that there are two functionally specialized cortical streams of visual processing originating in striate (V1) cortex: a dorsal, action-related "unconscious" stream and a ventral, perception-related "conscious" stream. As Milner and Goodale acknowledge, findings from blindsight studies suggest a more sophisticated picture that replaces the distinction between unconscious vision for action and conscious vision for perception with a tripartite division between unconscious vision for action, conscious vision for perception, and unconscious vision for perception. The combination excluded by the tripartite division is the possibility of conscious vision for action. But are there good grounds for concluding that there is no conscious vision for action? There is now overwhelming evidence that illusions and perceived size can have a significant effect on action (Bruno & Franz, 2009; Dassonville & Bala, 2004; Franz & Gegenfurtner, 2008; McIntosh & Lashley, 2008). There is also suggestive evidence that any sophisticated visual behavior requires collaboration between the two visual streams at every stage of the process (Schenk & McIntosh, 2010). I nonetheless want to make a case for the tripartite division between unconscious vision for action, conscious vision for perception, and unconscious vision for perception. My aim here is not to refute the evidence showing that conscious vision can affect action but rather to argue (a) that we cannot gain cognitive access to action-guiding dorsal stream representations, and (b) that these representations do not correlate with phenomenal consciousness. This vindicates the semi-conservative view that the dissociation hypothesis is best understood as a tripartite division. PMID:21790744

  13. Research to Action: an evaluation.

    PubMed

    Murphy, Gail Tomblin; Alder, Rob; MacKenzie, Adrian; Cook, Amanda; Maddalena, Victor

    2012-03-01

    The evaluation of the Research to Action project was conducted using an Outcome Mapping (OM) methodology (Earl et al. 2001) with a mixed-methods, repeat survey (before/after) study design. This design uses concurrent measurement of process and outcome indicators at baseline and follow-up. The RTA project proved effective at improving work environments and thereby promoting the retention and recruitment of nurses. Nurses involved in the RTA initiatives had a higher perception of leadership and support in their units, improved job satisfaction, increased empowerment and occupational commitment, and a greater intention to stay on the job.The pilot projects were most successful when there were clearly stated objectives, buy-in from nurses, support from the steering committee and management, and adequate communication among stakeholders. Committed coordination and leadership, both locally and nationally, were central to success.Considerable evidence has documented the challenges facing Canada's nursing human resources and their workplaces, such as high levels of turnover, excessive use of overtime and persistent shortages. There is a growing imperative to translate this research into action, and much of the available evidence presents viable policy alternatives for consideration. For example, a recent national synthesis report (Maddalena and Crupi 2008) recommended that, in consultation with stakeholders, processes should be put in place to share knowledge and best practices in nursing management, practice, staffing models and innovations in workplace health and well-being.Nurses across the country report a desire to be more involved in decisions affecting them and their patients (Wortsman and Janowitz 2006). A recent study on the shortage of registered nurses in Canada (Tomblin Murphy et al. 2009) highlighted the need for collaboration among governments, employers, unions and other stakeholders to improve working conditions for nurses. Another report notes the

  14. Decision Making in Action

    NASA Technical Reports Server (NTRS)

    Orasanu, Judith; Statler, Irving C. (Technical Monitor)

    1994-01-01

    contributes to performance because it assures that all crew members have essential information, but it also regulates and coordinates crew actions and is the medium of collective thinking in response to a problem. This presentation will examine the relations between leadership, communication, decision making and overall crew performance. Implications of these findings for spaceflight and training for offshore installations will be discussed.

  15. Administrative Actions for Noncompliance; Lesser Administrative Actions. Direct final rule.

    PubMed

    2016-04-01

    The Food and Drug Administration (FDA) is amending the regulation describing lesser administrative actions that may be imposed on an Institutional Review Board (IRB) that has failed to comply with FDA's IRB regulations. We are clarifying that FDA may require the IRB to withhold approval of new FDA-regulated studies, stop the enrollment of new subjects in ongoing studies, and terminate ongoing studies, or any combination of these actions until the noncompliance with FDA's IRB regulations is corrected. We are taking this action to ensure clarity and improve the accuracy of the regulations. PMID:27044118

  16. "Wuwei" (Non-Action) Philosophy and Actions: Rethinking "Actions" in School Reform

    ERIC Educational Resources Information Center

    Moon, Seungho

    2015-01-01

    This inquiry aims to enrich conversation regarding school reform. The author asks about what other discourses are possible when the action-oriented question of how to "act" is a major approach to "fix" current educational problems. Drawing from Taoist philosophy of "wuwei" (non-action), the author provides a frame to…

  17. Enforcement actions: Significant actions resolved individual actions. Semiannual progress report, January 1996--June 1996

    SciTech Connect

    1996-08-01

    This document summarizes significant enforcement actions that have been resolved during the period of January-June 1996. The report includes copies of Orders and Notices of Violations sent by the Nuclear Regulatory Commission to individuals with respect to the enforcement actions.

  18. Corrective Action Decision Document/Corrective Action Plan for Corrective Action Unit 447: Project Shoal Area, Subsurface, Nevada, Rev. No.: 3 with Errata Sheet

    SciTech Connect

    Tim Echelard

    2006-03-01

    of Energy (DOE) determined that the degree of uncertainty in transport predictions for PSA remained unacceptably large. As a result, a second CAIP was developed by DOE and approved by the Nevada Division of Environmental Protection (NDEP) in December 1998 (DOE/NV, 1998a). This plan prescribed a rigorous analysis of uncertainty in the Shoal model and quantification of methods of reducing uncertainty through data collection. This analysis is termed a Data Decision Analysis (Pohll et al., 1999a) and formed the basis for a second major characterization effort at PSA (Pohll et al., 1999b). The details for this second field effort are presented in an Addendum to the CAIP, which was approved by NDEP in April 1999 (DOE/NV, 1999a). Four additional characterization wells were drilled at PSA during summer and fall of 1999; details of the drilling and well installation are in IT Corporation (2000), with testing reported in Mihevc et al. (2000). A key component of the second field program was a tracer test between two of the new wells (Carroll et al., 2000; Reimus et al., 2003). Based on the potential exposure pathways, two corrective action objectives were identified for CAU 447: Prevent or mitigate exposure to groundwater contaminants of concern at concentrations exceeding regulatory maximum contaminant levels or risk-based levels; and Reduce the risk to human health and the environment to the extent practicable. Based on the review of existing data, the results of the modeling, future use, and current operations at PSA, the following alternatives have been developed for consideration at CAU 447: Alternative 1--No Further Action; Alternative 2--Proof-of-Concept and Monitoring with Institutional Controls; and Alternative 3--Contaminant Control. The corrective action alternatives were evaluated based on the approach outlined in the ''Focused Evaluation of Selected Remedial Alternatives for the Underground Test Area'' (DOE/NV, 1998b). Each alternative was assessed against nine

  19. Contextual specificity in perception and action

    NASA Technical Reports Server (NTRS)

    Proffitt, Dennis R.

    1991-01-01

    The visually guided control of helicopter flight is a human achievement, and, thus, understanding this skill is, in part, a psychological problem. The abilities of skilled pilots are impressive, and yet it is of concern that pilots' performance is less than ideal: they suffer from workload constraints, make occasional errors, and are subject to such debilities as simulator sickness. Remedying such deficiencies is both an engineering and a psychological problem. When studying the psychological aspects of this problem, it is desirable to simplify the problem as much as possible, and thereby, sidestep as many intractable psychological issues as possible. Simply stated, we do not want to have to resolve such polemics as the mind-body problem in order to contribute to the design of more effective helicopter systems. On the other hand, the study of human behavior is a psychological endeavor and certain problems cannot be evaded. Four related issues that are of psychological significance in understanding the visually guided control of helicopter flight are discussed. First, a selected discussion of the nature of descriptive levels in analyzing human perception and performance is presented. It is argued that the appropriate level of description for perception is kinematical, and for performance, it is procedural. Second, it is argued that investigations into pilot performance cannot ignore the nature of pilots' phenomenal experience. The conscious control of actions is not based upon environmental states of affairs, nor upon the optical information that specifies them. Actions are coupled to perceptions. Third, the acquisition of skilled actions in the context of inherent misperceptions is discussed. Such skills may be error prone in some situations, but not in others. Finally, I discuss the contextual relativity of human errors. Each of these four issues relates to a common theme: the control of action is mediated by phenomenal experience, the veracity of which is context

  20. The Action Execution Process Implemented in Different Cognitive Architectures: A Review

    NASA Astrophysics Data System (ADS)

    Dong, Daqi; Franklin, Stan

    2014-12-01

    An agent achieves its goals by interacting with its environment, cyclically choosing and executing suitable actions. An action execution process is a reasonable and critical part of an entire cognitive architecture, because the process of generating executable motor commands is not only driven by low-level environmental information, but is also initiated and affected by the agent's high-level mental processes. This review focuses on cognitive models of action, or more specifically, of the action execution process, as implemented in a set of popular cognitive architectures. We examine the representations and procedures inside the action execution process, as well as the cooperation between action execution and other high-level cognitive modules. We finally conclude with some general observations regarding the nature of action execution.

  1. Do Stimulus-Action Associations Contribute to Repetition Priming?

    ERIC Educational Resources Information Center

    Dennis, Ian; Perfect, Timothy J.

    2013-01-01

    Despite evidence that response learning makes a major contribution to repetition priming, the involvement of response representations at the level of motor actions remains uncertain. Levels of response representation were investigated in 4 experiments that used different tasks at priming and test. Priming for stimuli that required congruent…

  2. Action planning in a virtual context after prefrontal cortex damage.

    PubMed

    Zalla, T; Plassiart, C; Pillon, B; Grafman, J; Sirigu, A

    2001-01-01

    Patients with frontal lobe lesions are known to encounter severe problems in the organisation of their behaviour in everyday life. Script generation tasks assess the subject's conceptual ability to formulate and evaluate a coherent and structured plan of action. In the present study, we investigated to what extent neuropsychological deficits observed at the conceptual level of action knowledge lead to impairments in action execution. We examined seven patients with prefrontal cortex damage and sixteen normal subjects. Subjects were first asked to verbally formulate a plan of action and then to use this knowledge for 'executing' the actions in a virtual 3-dimensional interactive apartment presented on a computer screen. The results indicated that the presence of the realistic context improved patients' performance. However, specific impairments were observed in patients in the execution condition, namely actions slips, omissions, failure in initiating actions and purposeless displacements. Moreover, an analysis of planning time showed that, differently of the patients group, normal subjects spent more time during plan execution as compared to plan generation. These results suggest that after a frontal lobe lesion a defective formulation of a routine plan might affect the execution of the corresponding course of actions. PMID:11369400

  3. American Samoa Energy Action Plan

    SciTech Connect

    Haase, Scott; Esterly, Sean; Herdrich, David; Bodell, Tim; Visser, Charles

    2013-08-01

    Describes the five near-term strategies selected by the American Samoa Renewable Energy Committee (ASREC) during action planning workshops conducted in May 2013, and outlines the actions being taken to implement those strategies. Each option is tied to a priority identified in the earlier draft American Samoa Strategic Energy Plan as being an essential component of reducing American Samoa'spetroleum energy consumption. The actions described for each strategy provide a roadmap to facilitate the implementation of each strategy. This document is intended to evolve along with the advancement of the projects, and will be updated to reflect progress.

  4. Supergravity actions with integral forms

    NASA Astrophysics Data System (ADS)

    Castellani, L.; Catenacci, R.; Grassi, P. A.

    2014-12-01

    Integral forms provide a natural and powerful tool for the construction of supergravity actions. They are generalizations of usual differential forms and are needed for a consistent theory of integration on supermanifolds. The group geometrical approach to supergravity and its variational principle are reformulated and clarified in this language. Central in our analysis is the Poincaré dual of a bosonic manifold embedded into a supermanifold. Finally, using integral forms we provide a proof of Gates' so-called "Ectoplasmic Integration Theorem", relating superfield actions to component actions.

  5. Do good actions inspire good actions in others?

    PubMed Central

    Capraro, Valerio; Marcelletti, Alessandra

    2014-01-01

    Actions such as sharing food and cooperating to reach a common goal have played a fundamental role in the evolution of human societies. Despite the importance of such good actions, little is known about if and how they can spread from person to person to person. For instance, does being recipient of an altruistic act increase your probability of being cooperative with a third party? We have conducted an experiment on Amazon Mechanical Turk to test this mechanism using economic games. We have measured willingness to be cooperative through a standard Prisoner's dilemma and willingness to act altruistically using a binary Dictator game. In the baseline treatments, the endowments needed to play were given by the experimenters, as usual; in the control treatments, they came from a good action made by someone else. Across four different comparisons and a total of 572 subjects, we have never found a significant increase of cooperation or altruism when the endowment came from a good action. We conclude that good actions do not necessarily inspire good actions in others. While this is consistent with the theoretical prediction, it challenges the majority of other experimental studies. PMID:25502617

  6. Shaping up for action

    PubMed Central

    Denholm, Barry

    2013-01-01

    The Malpighian tubule is the main organ for excretion and osmoregulation in most insects. During a short period of embryonic development the tubules of Drosophila are shaped, undergo differentiation and become precisely positioned in the body cavity, so they become fully functional at the time of larval hatching a few hours later. In this review I explore three developmental events on the path to physiological maturation. First, I examine the molecular and cellular mechanisms that generate organ shape, focusing on the process of cell intercalation that drives tubule elongation, the roles of the cytoskeleton, the extracellular matrix and how intercalation is coordinated at the tissue level. Second, I look at the genetic networks that control the physiological differentiation of tubule cells and consider how distinctive physiological domains in the tubule are patterned. Finally, I explore how the organ is positioned within the body cavity and consider the relationship between organ position and function. PMID:23445869

  7. Cortisol level

    MedlinePlus

    ... enable JavaScript. The cortisol blood test measures the level of cortisol in the blood. Cortisol is a ... in the morning. This is important, because cortisol level varies throughout the day. You may be asked ...

  8. Triglyceride level

    MedlinePlus

    ... page: //medlineplus.gov/ency/article/003493.htm Triglyceride level To use the sharing features on this page, please enable JavaScript. The triglyceride level is a blood test to measure the amount ...

  9. Technology in action

    NASA Technical Reports Server (NTRS)

    1992-01-01

    In keeping with the NASA Administrator's announcement that technology transfer will become a fundamental mission of NASA, the Marshall Space Flight Center (MSFC) has initiated new programs to reach the heartland of U.S. industry. The Center has continued to expand its already well-established outreach program aimed at helping American business, industry, and academia at the grassroots level. The goal is to ensure that America regains and maintains its proper place of leadership among the world's technologically developed nations. MSFC's national goal is to enhance America's competitiveness in the world marketplace, fortify the value of the dollar, and ensure technological breakthroughs by American laboratories benefit taxpayers and industries. The Technology Utilization (TU) Office at MSFC believes a number of measures are possible to slow, then halt, and ultimately reverse the erosion of American technological leadership. MSFC's TU Office is reaching out to American industry on an increasingly broadening scope, facilitating the transfer of NASA derived technologies to American businesses, industries, educational institutions, and individuals. There are many valid approaches to achieving this goal. Some, such as the National Technology Initiative, begin at the top and work down through America's top corporate structure. Others, such as the technology transfer program that MSFC has implemented, begin at the one-on-one, grassroots level -- working with small and medium-sized firms that form the bulk of American industry. What can be done by one NASA center is, admittedly, limited. But by extrapolating this one-on-one approach to the more than 700 Federal laboratories, a great deal can be accomplished. This report contains an examination of outreach and in reach programs, problem statements programs, applications projects, new technology reporting, new technology administration, and the need for increased resources to further facilitate technology transfer.

  10. Temporal dynamics of action perception: differences on ERP evoked by object-related and non-object-related actions.

    PubMed

    Wamain, Yannick; Pluciennicka, Ewa; Kalénine, Solène

    2014-10-01

    While neuropsychological dissociations suggest that distinct processes are involved in execution or perception of transitive (object-related) and intransitive (non-object-related) actions, the few neuroimaging studies that directly contrasted the brain activations underlying transitive and intransitive gesture perception failed to find substantial differences between the two action types. However, the distinction could be visible on brain activity timing within the fronto-parietal network. In this study, we used Event-Related Potential (ERP) method to assess the temporal dynamics of object-related and non-object-related action processing. Although both meaningful, only object-related actions involve object motor features. Accordingly, perception of the two action types would show distinct neural correlates. Participants were presented with four movie types (ORA, Object-Related Action, NORA: Non-Object-Related Action and 2 control movies) and were instructed to perform tasks that required explicit or implicit action recognition (specific action recognition or color change detection). Movies were presented as Point-Light Display (PLD) and thus provided only information about gesture kinematics regardless of action type. ERP were computed during movie visual perception and analyzed as a function of movie type and task. The main result revealed a difference between ORA and NORA on the amplitude of the P3a component in the fronto-parietal region. The difference observed around 250 ms after movie onset do not likely origin from variation in low-level visual features or attention resource allocation. Instead, we suggest that it reflects incidental recruitment of object attributes during object-related action perception. The exact nature of these attributes is discussed. PMID:25204513

  11. Decoding Concrete and Abstract Action Representations During Explicit and Implicit Conceptual Processing.

    PubMed

    Wurm, Moritz F; Ariani, Giacomo; Greenlee, Mark W; Lingnau, Angelika

    2016-08-01

    Action understanding requires a many-to-one mapping of perceived input onto abstract representations that generalize across concrete features. It is debated whether such abstract action concepts are encoded in ventral premotor cortex (PMv; motor hypothesis) or, alternatively, are represented in lateral occipitotemporal cortex (LOTC; cognitive hypothesis). We used fMRI-based multivoxel pattern analysis to decode observed actions at concrete and abstract, object-independent levels of representation. Participants observed videos of 2 actions involving 2 different objects, using either an explicit or implicit task with respect to conceptual action processing. We decoded concrete action representations by training and testing a classifier to discriminate between actions within each object category. To identify abstract action representations, we trained the classifier to discriminate actions in one object and tested the classifier on actions performed on the other object, and vice versa. Region-of-interest and searchlight analyses revealed decoding in LOTC at both concrete and abstract levels during both tasks, whereas decoding in PMv was restricted to the concrete level during the explicit task. In right inferior parietal cortex, decoding was significant for the abstract level during the explicit task. Our findings are incompatible with the motor hypothesis, but support the cognitive hypothesis of action understanding. PMID:26223260

  12. Eicosanoid actions in insect immunology

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In this chapter we review eicosanoid actions in insect immunity. Eicosanoids are oxygenated metabolites of arachidonic acid (AA) and two other C20 polyunsaturated polyunsaturated fatty acids. Groups of eicosanoids include prostaglandins, lipoxygenase products and epoxyeicosatrienoic acids. These ...

  13. Technology assessment and citizen action

    NASA Technical Reports Server (NTRS)

    Mottur, E. R.

    1972-01-01

    The importance of citizen participation in the assessment process is discussed, and a system for citizen assessment action is proposed. A national assessment system is outlined. Citizen participation is considered essential in the assessment process, and impediments to effective action taken by citizens are discussed. These impediments are finance, organization and motivation, and information. The establishment of citizens' assessment associations is proposed, whose functioning would be fostered and regulated by the Citizens' Assessment Administration. The organization, functions, and financing of these associations are described. The implications of citizen action are indicated as the extensive use of class action suits, the broad interpretation of associated costs of litigation, and the use of present scientific research as evidence to assert that it is reasonable to conclude that certain consequences are probable to occur in the future.

  14. InterAction Database (IADB)

    Cancer.gov

    The InterAction Database includes demographic and prescription information for more than 500,000 patients in the northern and middle Netherlands and has been integrated with other systems to enhance data collection and analysis.

  15. ICDF Complex Remedial Action Report

    SciTech Connect

    W. M. Heileson

    2007-09-26

    This Idaho CERCLA Disposal Facility (ICDF) Remedial Action Report has been prepared in accordance with the requirements of Section 6.2 of the INEEL CERCLA Disposal Facility Remedial Action Work Plan. The agency prefinal inspection of the ICDF Staging, Storage, Sizing, and Treatment Facility (SSSTF) was completed in June of 2005. Accordingly, this report has been developed to describe the construction activities completed at the ICDF along with a description of any modifications to the design originally approved for the facility. In addition, this report provides a summary of the major documents prepared for the design and construction of the ICDF, a discussion of relevant requirements and remedial action objectives, the total costs associated with the development and operation of the facility to date, and identification of necessary changes to the Agency-approved INEEL CERCLA Disposal Facility Remedial Action Work Plan and the ICDF Complex Operations and Maintenance Plan.

  16. What's an Asthma Action Plan?

    MedlinePlus

    ... KidsHealth in the Classroom What Other Parents Are Reading Upsetting News Reports? What to Say Vaccines: Which ... flow meters. Action plans use symptoms, peak flow readings, or both to help you determine the zone ...

  17. The Concept of Action Research.

    ERIC Educational Resources Information Center

    Altrichter, Herbert; Kemmis, Stephen; McTaggart, Robin; Zuber-Skerritt, Ortrun

    2002-01-01

    Explains why definition of action research is problematic and presents working definitions developed internationally that indicate its nature, philosophy, and methodology. Suggests that pragmatic approaches to definition serve communication purposes without narrowly confining the concept. (SK)

  18. REMEDIAL ACTION COSTING PROCEDURES MANUAL

    EPA Science Inventory

    The manual provides specific procedures for the cost estimating and economic analysis steps required for preparing engineering cost estimates for selecting remedial action alternatives in response to the requirements of the Comprehensive Environmental Response, Compensation, and ...

  19. Method for triggering an action

    DOEpatents

    Hall, David R.; Bartholomew, David B.; Johnson, Monte L.; Moon, Justin; Koehler, Roger O.

    2006-10-17

    A method for triggering an action of at least one downhole device on a downhole network integrated into a downhole tool string synchronized to an event comprises determining latency, sending a latency adjusted signal, and performing the action. The latency is determined between a control device and the at least one downhole device. The latency adjusted signal for triggering an action is sent to the downhole device. The action is performed downhole synchronized to the event. A preferred method for determining latency comprises the steps: a control device sends a first signal to the downhole device; after receiving the signal, the downhole device sends a response signal to the control device; and the control device analyzes the time from sending the signal to receiving the response signal.

  20. 36 CFR 72.13 - Action plan.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Action plan. 72.13 Section 72... AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.13 Action plan. The purpose of the Assessment is to provide background and justification for an Action Plan. The Action Plan,...

  1. 36 CFR 72.13 - Action plan.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Action plan. 72.13 Section 72... AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.13 Action plan. The purpose of the Assessment is to provide background and justification for an Action Plan. The Action Plan,...

  2. 36 CFR 72.13 - Action plan.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Action plan. 72.13 Section 72... AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.13 Action plan. The purpose of the Assessment is to provide background and justification for an Action Plan. The Action Plan,...

  3. Seeking Conceptual Clarity in the Action Modalities

    ERIC Educational Resources Information Center

    Raelin, Joe

    2009-01-01

    This article begins with the presumption that action learning has not made as deep an impact in promoting participatory social change as its supporters may have hoped for, but nor has its cousin action modalities, such as action research and action science. These action strategies have evolved separately along distinct traditions and, rather than…

  4. 12 CFR 272.4 - Committee actions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Committee actions. 272.4 Section 272.4 Banks....4 Committee actions. (a) Actions at meetings. Actions are taken at meetings of the Committee except as described below. (b) Actions between meetings. Special circumstances may make it desirable in...

  5. 45 CFR 1225.19 - Corrective action.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Corrective action. 1225.19 Section 1225.19 Public... Corrective action. (a) When discrimination is found, Peace Corps or ACTION must take appropriate action to... corrective action to the agent and other class members in accordance with § 1225.10 of this part. (b)...

  6. Segmenting Dynamic Human Action via Statistical Structure

    ERIC Educational Resources Information Center

    Baldwin, Dare; Andersson, Annika; Saffran, Jenny; Meyer, Meredith

    2008-01-01

    Human social, cognitive, and linguistic functioning depends on skills for rapidly processing action. Identifying distinct acts within the dynamic motion flow is one basic component of action processing; for example, skill at segmenting action is foundational to action categorization, verb learning, and comprehension of novel action sequences. Yet…

  7. Incongruent Imagery Interferes with Action Initiation

    ERIC Educational Resources Information Center

    Ramsey, Richard; Cumming, Jennifer; Eastough, Daniel; Edwards, Martin G.

    2010-01-01

    It has been suggested that representing an action through observation and imagery share neural processes with action execution. In support of this view, motor-priming research has shown that observing an action can influence action initiation. However, there is little motor-priming research showing that imagining an action can modulate action…

  8. 12 CFR 272.4 - Committee actions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 3 2011-01-01 2011-01-01 false Committee actions. 272.4 Section 272.4 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) FEDERAL OPEN MARKET COMMITTEE RULES OF PROCEDURE § 272.4 Committee actions. (a) Actions at meetings. Actions are taken at meetings of the Committee except as described below. (b) Actions between...

  9. Complexity, action, and black holes

    DOE PAGESBeta

    Brown, Adam R.; Roberts, Daniel A.; Susskind, Leonard; Swingle, Brian; Zhao, Ying

    2016-04-18

    In an earlier paper "Complexity Equals Action" we conjectured that the quantum computational complexity of a holographic state is given by the classical action of a region in the bulk (the `Wheeler-DeWitt' patch). We provide calculations for the results quoted in that paper, explain how it fits into a broader (tensor) network of ideas, and elaborate on the hypothesis that black holes are the fastest computers in nature.

  10. Complexity, action, and black holes

    NASA Astrophysics Data System (ADS)

    Brown, Adam R.; Roberts, Daniel A.; Susskind, Leonard; Swingle, Brian; Zhao, Ying

    2016-04-01

    Our earlier paper "Complexity Equals Action" conjectured that the quantum computational complexity of a holographic state is given by the classical action of a region in the bulk (the "Wheeler-DeWitt" patch). We provide calculations for the results quoted in that paper, explain how it fits into a broader (tensor) network of ideas, and elaborate on the hypothesis that black holes are the fastest computers in nature.

  11. Tactile perception during action observation.

    PubMed

    Vastano, Roberta; Inuggi, Alberto; Vargas, Claudia D; Baud-Bovy, Gabriel; Jacono, Marco; Pozzo, Thierry

    2016-09-01

    It has been suggested that tactile perception becomes less acute during movement to optimize motor control and to prevent an overload of afferent information generated during action. This empirical phenomenon, known as "tactile gating effect," has been associated with mechanisms of sensory feedback prediction. However, less attention has been given to the tactile attenuation effect during the observation of an action. The aim of this study was to investigate whether and how the observation of a goal-directed action influences tactile perception as during overt action. In a first experiment, we recorded vocal reaction times (RTs) of participants to tactile stimulations during the observation of a reach-to-grasp action. The stimulations were delivered on different body parts that could be either congruent or incongruent with the observed effector (the right hand and the right leg, respectively). The tactile stimulation was contrasted with a no body-related stimulation (an auditory beep). We found increased RTs for tactile congruent stimuli compared to both tactile incongruent and auditory stimuli. This effect was reported only during the observation of the reaching phase, whereas RTs were not modulated during the grasping phase. A tactile two-alternative forced-choice (2AFC) discrimination task was then conducted in order to quantify the changes in tactile sensitivity during the observation of the same goal-directed actions. In agreement with the first experiment, the tactile perceived intensity was reduced only during the reaching phase. These results suggest that tactile processing during action observation relies on a process similar to that occurring during action execution. PMID:27161552

  12. TACT: The Action Computation Tool

    NASA Astrophysics Data System (ADS)

    Sanders, Jason L.; Binney, James

    2015-12-01

    The Action Computation Tool (TACT) tests methods for estimating actions, angles and frequencies of orbits in both axisymmetric and triaxial potentials, including general spherical potentials, analytic potentials (Isochrone and Harmonic oscillator), axisymmetric Stackel fudge, average generating function from orbit (AvGF), and others. It is written in C++; code is provided to compile the routines into a Python library. TM (ascl:1512.014) and LAPACK are required to access some features.

  13. Periostin action in bone.

    PubMed

    Bonnet, Nicolas; Garnero, Patrick; Ferrari, Serge

    2016-09-01

    Periostin is a highly conserved matricellular protein that shares close homology with the insect cell adhesion molecule fasciclin 1. Periostin is expressed in a broad range of tissues including the skeleton, where it serves both as a structural molecule of the bone matrix and a signaling molecule through integrin receptors and Wnt-beta-catenin pathways whereby it stimulates osteoblast functions and bone formation. The development of periostin null mice has allowed to elucidate the crucial role of periostin on dentinogenesis and osteogenesis, as well as on the skeletal response to mechanical loading and parathyroid hormone. The use of circulating periostin as a potential clinical biomarker has been explored in different non skeletal conditions. These include cancers and more specifically in the metastasis process, respiratory diseases such as asthma, kidney failure, renal injury and cardiac infarction. In postmenopausal osteoporosis, serum levels have been shown to predict the risk of fracture-more specifically non-vertebral- independently of bone mineral density. Because of its preferential localization in cortical bone and periosteal tissue, it can be speculated that serum periostin may be a marker of cortical bone metabolism, although additional studies are clearly needed. PMID:26721738

  14. The timing and precision of action prediction in the aging brain.

    PubMed

    Diersch, Nadine; Jones, Alex L; Cross, Emily S

    2016-01-01

    Successful social interactions depend on the ability to anticipate other people's actions. Current conceptualizations of brain function propose that causes of sensory input are inferred through their integration with internal predictions generated in the observer's motor system during action observation. Less is known concerning how action prediction changes with age. Previously we showed that internal action representations are less specific in older compared with younger adults at behavioral and neural levels. Here, we characterize how neural activity varies while healthy older adults aged 56-71 years predict the time-course of an unfolding action as well as the relation to task performance. By using fMRI, brain activity was measured while participants observed partly occluded actions and judged the temporal coherence of the action continuation that was manipulated. We found that neural activity in frontoparietal and occipitotemporal regions increased the more an action continuation was shifted backwards in time. Action continuations that were shifted towards the future preferentially engaged early visual cortices. Increasing age was associated with neural activity that extended from posterior to anterior regions in frontal and superior temporal cortices. Lower sensitivity in action prediction resulted in activity increases in the caudate. These results imply that the neural implementation of predicting actions undergoes similar changes as the neural process of executing actions in older adults. The comparison between internal predictions and sensory input seems to become less precise with age leading to difficulties in anticipating observed actions accurately, possibly due to less specific internal action models. PMID:26503586

  15. Human action recognition using motion energy template

    NASA Astrophysics Data System (ADS)

    Shao, Yanhua; Guo, Yongcai; Gao, Chao

    2015-06-01

    Human action recognition is an active and interesting research topic in computer vision and pattern recognition field that is widely used in the real world. We proposed an approach for human activity analysis based on motion energy template (MET), a new high-level representation of video. The main idea for the MET model is that human actions could be expressed as the composition of motion energy acquired in a three-dimensional (3-D) space-time volume by using a filter bank. The motion energies were directly computed from raw video sequences, thus some problems, such as object location and segmentation, etc., are definitely avoided. Another important competitive merit of this MET method is its insensitivity to gender, hair, and clothing. We extract MET features by using the Bhattacharyya coefficient to measure the motion energy similarity between the action template video and the tested video, and then the 3-D max-pooling. Using these features as input to the support vector machine, extensive experiments on two benchmark datasets, Weizmann and KTH, were carried out. Compared with other state-of-the-art approaches, such as variation energy image, dynamic templates and local motion pattern descriptors, the experimental results demonstrate that our MET model is competitive and promising.

  16. Action-Oriented Benchmarking: Concepts and Tools

    SciTech Connect

    California Energy Commission; Mathew, Paul; Mills, Evan; Mathew, Paul; Piette, Mary Ann; Bourassa, Norman; Brook, Martha

    2008-02-13

    Most energy benchmarking tools provide static feedback on how one building compares to a larger set of loosely similar buildings, without providing information at the end-use level or on what can be done to reduce consumption, cost, or emissions. In this article--Part 1 of a two-part series--we describe an 'action-oriented benchmarking' approach, which extends whole-building energy benchmarking to include analysis of system and component energy use metrics and features. Action-oriented benchmarking thereby allows users to generate more meaningful metrics and to identify, screen and prioritize potential efficiency improvements. This opportunity assessment process can then be used to inform and optimize a full-scale audit or commissioning process. We introduce a new web-based action-oriented benchmarking system and associated software tool-EnergyIQ. The benchmarking methods, visualizations, and user interface design are informed by an end-user needs assessment survey and best-practice guidelines from ASHRAE.

  17. Challenges to participation in action research.

    PubMed

    de Toledo, Renata Ferraz; Giatti, Leandro Luiz

    2015-03-01

    In order to understand and take action in complex health and environmental issues, we intend to analyse the conditions that are needed for those at risk to participate in research and intervention projects. In this study, we describe and discuss an action research experience carried out with an indigenous community in the Brazilian Amazon that suffers from serious sanitary problems, where cultural aspects in the relationship with the environment and health are particularly relevant. Different types of tools were deployed and combined and were subsequently classified according to their dialectic efficacy and ability to both conduct and steer the research and encourage the participation of social actors within a process of feedback. Even tools that were considered to be non-dialectic proved to be important sources of feedback. We present a research flow as a model of analysis and a framework for implementing action research, in which challenges to the participation of social actors are classified according to their priority through a critical review of the methodology developed. These challenges are social mobilization, co-operation, appropriation and a proactive stance. We conclude that a cyclic combination of dialectic and non-dialectic tools can increase participation, which though difficult to achieve is nevertheless necessary. During the development of this process, social mobilization is a prerequisite, whereas a proactive stance, the highest level of participation, requires continuous effort and the successive deployment of a variety of tools. PMID:25239444

  18. Let's Start Leveling about Leveling

    ERIC Educational Resources Information Center

    Glasswell, Kath; Ford, Michael

    2011-01-01

    In this article, the authors propose a revised way of thinking about reading levels, one that promotes a wider and more flexible view of teacher decision making about the use of leveled texts in classrooms. They share five key principles to consider when looking at the use of instruction that involves matching leveled materials with readers.…

  19. 78 FR 18420 - Special Permit Applications Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... Pipeline and Hazardous Materials Safety Administration Special Permit Applications Actions AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice of actions on special... processing of, special permits from the Department of Transportation's Hazardous Material Regulations (49...

  20. 77 FR 12865 - Enforcement Actions Summary

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-02

    ... Government Printing Office's Web page at http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR... SECURITY Transportation Security Administration Enforcement Actions Summary AGENCY: Transportation Security Administration, DHS. ACTION: Notice of availability. SUMMARY: The Transportation Security Administration (TSA)...

  1. 78 FR 11216 - Enforcement Actions Summary

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-15

    ... Government Printing Office's web page at http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR... SECURITY Transportation Security Administration Enforcement Actions Summary AGENCY: Transportation Security Administration, DHS. ACTION: Notice of availability. SUMMARY: The Transportation Security Administration (TSA)...

  2. Enforcement actions: Significant actions resolved individual actions. Semiannual progress report, January 1997--June 1997

    SciTech Connect

    1997-09-01

    This compilation summarizes significant enforcement actions that have been resolved during the period (January - June 1997) and includes copies of Orders and Notices of Violation sent by the Nuclear Regulatory Commission to individuals with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC. The Commission believes this information may be useful to licensees in making employment decisions.

  3. Enforcement actions: Significant actions resolved individuals actions. Semiannual progress report, July--December 1996

    SciTech Connect

    1997-04-01

    This compilation summarizes significant enforcement actions that have been resolved during the period (July - December 1996) and includes copies of Orders and Notices of Violation sent by the Nuclear Regulatory Commission to individuals with respect to-these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC. The Commission believes this information may be useful to licensees in making employment decisions.

  4. Corrective Action Decision Document for Corrective Action Unit 417: Central Nevada Test Area Surface, Nevada

    SciTech Connect

    U.S. Department of Energy Nevada Operations Office

    1999-04-02

    This Corrective Action Decision Document (CADD) identifies and rationalizes the U.S. Department of Energy, Nevada Operations Office's selection of a recommended corrective action alternative (CAA) appropriate to facilitate the closure of Corrective Action Unit (CAU) 417: Central Nevada Test Area Surface, Nevada, under the Federal Facility Agreement and Consent Order. Located in Hot Creek Valley in Nye County, Nevada, and consisting of three separate land withdrawal areas (UC-1, UC-3, and UC-4), CAU 417 is comprised of 34 corrective action sites (CASs) including 2 underground storage tanks, 5 septic systems, 8 shaker pad/cuttings disposal areas, 1 decontamination facility pit, 1 burn area, 1 scrap/trash dump, 1 outlier area, 8 housekeeping sites, and 16 mud pits. Four field events were conducted between September 1996 and June 1998 to complete a corrective action investigation indicating that the only contaminant of concern was total petroleum hydrocarbon (TPH) which was found in 18 of the CASs. A total of 1,028 samples were analyzed. During this investigation, a statistical approach was used to determine which depth intervals or layers inside individual mud pits and shaker pad areas were above the State action levels for the TPH. Other related field sampling activities (i.e., expedited site characterization methods, surface geophysical surveys, direct-push geophysical surveys, direct-push soil sampling, and rotosonic drilling located septic leachfields) were conducted in this four-phase investigation; however, no further contaminants of concern (COCs) were identified. During and after the investigation activities, several of the sites which had surface debris but no COCs were cleaned up as housekeeping sites, two septic tanks were closed in place, and two underground storage tanks were removed. The focus of this CADD was to identify CAAs which would promote the prevention or mitigation of human exposure to surface and subsurface soils with contaminant

  5. Corrective Action Decision Document/Closure Report for Corrective Action Unit 232: Area 25 Sewage Lagoons, Nevada Test Site, Nevada

    SciTech Connect

    US Department of Energy Nevada Operations Office

    1999-12-23

    This Corrective Action Decision Document/Closure Report (CADD/CR) has been prepared for Corrective Action Unit (CAU) 232, Area 25 Sewage Lagoons, in accordance with the Federal Facility Agreement and Consent Order. Located at the Nevada Test Site in Nevada, approximately 65 miles northwest of Las Vegas, CAU 232 is comprised of Corrective Action Site 25-03-01, Sewage Lagoon. This CADD/CR identifies and rationalizes the U.S. Department of Energy, Nevada Operations Office's (DOE/NV's) recommendation that no corrective action is deemed necessary for CAU 232. The Corrective Action Decision Document and Closure Report have been combined into one report because sample data collected during the July 1999 corrective action investigation (CAI) activities disclosed no evidence of contamination at the site. Contaminants of potential concern (COPCs) addressed during the CAI included total volatile organic compounds, total semivolatile organic compounds, total Resource Conservation and Recovery Act metals, total pesticides, total herbicides, total petroleum hydrocarbons (gasoline and diesel/oil range), polychlorinated biphenyls, isotopic uranium, isotopic plutonium, strontium-90, and gamma-emitting radionuclides. The data confirmed that none of the COPCs identified exceeded preliminary action levels outlined in the CAIP; therefore, no corrective actions were necessary for CAU 232. After the CAI, best management practice activities were completed and included installation of a fence and signs to limit access to the lagoons, cementing Manhole No. 2 and the diverter box, and closing off influent and effluent ends of the sewage lagoon piping. As a result of the CAI, the DOE/NV recommended that: (1) no further actions were required; (2) no Corrective Action Plan would be required; and (3) no use restrictions were required to be placed on the CAU.

  6. Corrective Action Decision Document for Corrective Action Unit 240: Area 25 Vehicle Washdown, Nevada Test Site, Nevada

    SciTech Connect

    US Department of Energy Nevada Operations Office

    1999-09-16

    This Corrective Action Decision Document identifies and rationalizes the U.S. Department of Energy, Nevada Operations Offices's selection of a recommended corrective action alternative (CAA) appropriate to facilitate the closure of Corrective Action Unit (CAU) 240: Area 25 Vehicle Washdown, Nevada Test Site, Nevada. This corrective action investigation was conducted in accordance with the Corrective Action Investigation Plan for CAU 240 as developed under the Federal Facility Agreement and Consent Order. Located in Area 25 at the Nevada Test Site in Nevada, CAU 240 is comprised of three Corrective Action Sites (CASs): 25-07-01, Vehicle Washdown Area (Propellant Pad); 25-07-02, Vehicle Washdown Area (F and J Roads Pad); and 25-07-03, Vehicle Washdown Station (RADSAFE Pad). In March 1999, the corrective action investigation was performed to detect and evaluate analyte concentrations against preliminary action levels (PALs) to determine contaminants of concern (COCs). There were no COCs identified at CAS 25-07-01 or CAS 25-07-03; therefore, there was no need for corrective action at these two CASs. At CAS 25-07-02, diesel-range organics and radionuclide concentrations in soil samples from F and J Roads Pad exceeded PALs. Based on this result, potential CAAs were identified and evaluated to ensure worker, public, and environmental protection against potential exposure to COCs in accordance with Nevada Administrative Code 445A. Following a review of potential exposure pathways, existing data, and future and current operations in Area 25, two CAAs were identified for CAU 240 (CAS 25-07-02): Alternative 1 - No Further Action and Alternative 2 - Clean Closure by Excavation and Disposal. Alternative 2 was identified as the preferred alternative. This alternative was judged to meet all requirements for the technical components evaluated, compliance with all applicable state and federal regulations for closure of the site, as well as minimizing potential future exposure

  7. Body-Specific Motor Imagery of Hand Actions: Neural Evidence from Right- and Left-Handers

    PubMed Central

    Willems, Roel M.; Toni, Ivan; Hagoort, Peter; Casasanto, Daniel

    2009-01-01

    If motor imagery uses neural structures involved in action execution, then the neural correlates of imagining an action should differ between individuals who tend to execute the action differently. Here we report fMRI data showing that motor imagery is influenced by the way people habitually perform motor actions with their particular bodies; that is, motor imagery is ‘body-specific’ (Casasanto, 2009). During mental imagery for complex hand actions, activation of cortical areas involved in motor planning and execution was left-lateralized in right-handers but right-lateralized in left-handers. We conclude that motor imagery involves the generation of an action plan that is grounded in the participant's motor habits, not just an abstract representation at the level of the action's goal. People with different patterns of motor experience form correspondingly different neurocognitive representations of imagined actions. PMID:19949484

  8. Cortical activation to action perception is associated with action production abilities in young infants.

    PubMed

    Lloyd-Fox, Sarah; Wu, Rachel; Richards, John E; Elwell, Clare E; Johnson, Mark H

    2015-02-01

    The extent to which perception and action share common neural processes is much debated in cognitive neuroscience. Taking a developmental approach to this issue allows us to assess whether perceptual processing develops in close association with the emergence of related action skills within the same individual. The current study used functional near-infrared spectroscopy (fNIRS) to investigate the perception of human action in 4- to 6-month-old human infants. In addition, the infants' manual dexterity was assessed using the fine motor component of The Mullen Scales of Early Learning and an in-house developed Manual Dexterity task. Results show that the degree of cortical activation, within the posterior superior temporal sulcus--temporoparietal junction (pSTS-TPJ) region, to the perception of manual actions in individual infants correlates with their own level of fine motor skills. This association was not fully explained by either measures of global attention (i.e., looking time) or general developmental stage. This striking concordance between the emergence of motor skills and related perceptual processing within individuals is consistent with experience-related cortical specialization in the developing brain. PMID:23975948

  9. Stress intensifies demands on response selection during action cascading processes.

    PubMed

    Yildiz, Ali; Wolf, Oliver T; Beste, Christian

    2014-04-01

    Stress has been shown to modulate a number of cognitive processes including action control. These functions are important in daily life and are mediated by various cognitive subprocesses. However, it is unknown if stress affects the whole processing cascade, or exerts specific effects on a restricted subset of processes involved in the chaining of actions. We examine the effects of stress on action selection processes in a stop-change paradigm and apply event-related potentials (ERPs) combined with source localization analysis to examine potentially restricted effects of stress on subprocesses mediating action cascading. The results show that attentional selection processes, as well as processes related to allocation of processing resources were not affected by stress. Stress only seems to affect response selection functions during action cascading and leads to slowing of responses when two actions are executed in succession. These changes are related to the anterior cingulate cortex (ACC). Changes in response selection were predictable on the basis of individual salivary cortisol levels. The results show that stress does not affect the whole processing cascade involved in the cascading of different actions, but seems to exert circumscribed effects on response selection processes which have previously been shown to depend on dopaminergic neural transmission. PMID:24636514

  10. Harm avoiders suppress motor resonance to observed immoral actions

    PubMed Central

    Candidi, Matteo; Sforza, Anna Laura; Aglioti, Salvatore Maria

    2015-01-01

    Motor resonance (MR) contingent upon action observation is thought to occur largely automatically. Although recent studies suggest that this process is not completely impervious to top-down modulations, much less is known on the possible role of the moral connotation of observed action goal in modulating MR. Here, we explored whether observing actions with different moral connotations modulates MR and whether any modulation depends on the onlookers’ personality. To this aim, we recorded motor potentials evoked by single-pulse transcranial magnetic stimulation from hand muscles of participants who were watching images of a model performing hand actions with the same postures and low-level goals (i.e. grasping an object) but with different moral connotations (‘stealing a wallet’ vs ‘picking up a notepaper’). Participants’ personality traits were measured using the temperament and character inventory. Results show a selective suppression of corticospinal excitability during observation of immoral actions in individuals with high scores in harm avoidance, a personality trait characterized by excessive worrying and fearfulness. Thus, a combination of dispositional (personality traits) and situational (morality of an action) variables appears to influence MR with the observed actions. PMID:24526183

  11. Object and Action Naming in Children With Specific Language Impairment

    PubMed Central

    Sheng, Li; McGregor, Karla K.

    2012-01-01

    Purpose In this study, the authors aimed to examine the accuracy, latency, and errors of noun (object) and verb (action) naming in children with and without specific language impairment (SLI) and to determine whether children with SLI have a particularly large noun–verb performance gap. Method Children with SLI, age-matched peers (AM), and expressive vocabulary–matched peers (VM) named 120 matched object and action pictures in a computerized confrontation naming task. Results The SLI and VM groups demonstrated comparable naming latency and accuracy; both were slower and less accurate than the AM group. Object naming was more accurate than action naming in the SLI and VM groups; their noun–verb performance gaps were comparable. Object naming was faster than action naming in all children. In comparison with the AM group, the SLI group made proportionally fewer taxonomic errors and more omission errors when naming objects, and fewer misperception errors when naming actions. Conclusions The naming abilities of children with SLI, although deficient given their chronological age, are commensurate with their vocabulary level. Their naming errors suggest immaturities in semantic representation. Action naming is significantly more difficult than object naming, but the noun–verb gap that characterizes the performance of children with SLI is appropriate for their vocabulary level. PMID:20705739

  12. Efficient computation of optimal actions

    PubMed Central

    Todorov, Emanuel

    2009-01-01

    Optimal choice of actions is a fundamental problem relevant to fields as diverse as neuroscience, psychology, economics, computer science, and control engineering. Despite this broad relevance the abstract setting is similar: we have an agent choosing actions over time, an uncertain dynamical system whose state is affected by those actions, and a performance criterion that the agent seeks to optimize. Solving problems of this kind remains hard, in part, because of overly generic formulations. Here, we propose a more structured formulation that greatly simplifies the construction of optimal control laws in both discrete and continuous domains. An exhaustive search over actions is avoided and the problem becomes linear. This yields algorithms that outperform Dynamic Programming and Reinforcement Learning, and thereby solve traditional problems more efficiently. Our framework also enables computations that were not possible before: composing optimal control laws by mixing primitives, applying deterministic methods to stochastic systems, quantifying the benefits of error tolerance, and inferring goals from behavioral data via convex optimization. Development of a general class of easily solvable problems tends to accelerate progress—as linear systems theory has done, for example. Our framework may have similar impact in fields where optimal choice of actions is relevant. PMID:19574462

  13. Is the organisation of goal-directed action modality specific? A common temporal structure.

    PubMed

    Weiss, P H; Jeannerod, M; Paulignan, Y; Freund, H J

    2000-01-01

    With the help of kinematic analysis, the temporal organization of the complex daily activity 'drinking from a bottle with a glass' was described in detail. The analysis focused on the sequential action structure, the prehensile acts, and the bimanual coordination as well as on the effect of different instruction modalities on these parameters to explore the underlying representation for this complex action. Movements of the two arms were recorded in three-dimensional space with the help of an optoelectronic device in 12 normal subjects under four conditions: (1) action pantomime after verbal instruction; (2) action imitation after observation of the action performed by the experimenter without the objects; (3) action pantomime while seeing, but not touching the objects; and finally (4) action execution with objects. Despite high execution variability, the temporal structure of the action could be precisely described by the relative duration and peak velocity of action segments, by the MGA-object size-correlation, and by linear regression analysis between the onsets of functionally related action segments. A similar structure of the action as characterized by these kinematic parameters was retained across different instruction modalities. Only when the action was executed with the objects, the interval between the movement onsets of either hand and the peak velocity of the manipulative acts were reduced, while no change was observed across the other three instruction modalities. This stability of the temporal structure suggests the existence of a level in the representation of an action where all the modalities converge. PMID:10838148

  14. Remedial Action Contacts Directory - 1997

    SciTech Connect

    1997-05-01

    This document, which was prepared for the US Department of Energy (DOE) Office of Environmental Restoration (ER), is a directory of 2628 individuals interested or involved in environmental restoration and/or remedial actions at radioactively contaminated sites. This directory contains a list of mailing addresses and phone numbers of DOE operations, area, site, project, and contractor offices; an index of DOE operations, area, site, project, and contractor office sorted by state; a list of individuals, presented by last name, facsimile number, and e-mail address; an index of affiliations presented alphabetically, with individual contacts appearing below each affiliation name; and an index of foreign contacta sorted by country and affiliation. This document was generated from the Remedial Action Contacts Database, which is maintained by the Remedial Action Program Information Center (RAPIC).

  15. Mechanisms of Action of Adjuvants

    PubMed Central

    Awate, Sunita; Babiuk, Lorne A.; Mutwiri, George

    2013-01-01

    Adjuvants are used in many vaccines, but their mechanisms of action are not fully understood. Studies from the past decade on adjuvant mechanisms are slowly revealing the secrets of adjuvant activity. In this review, we have summarized the recent progress in our understanding of the mechanisms of action of adjuvants. Adjuvants may act by a combination of various mechanisms including formation of depot, induction of cytokines and chemokines, recruitment of immune cells, enhancement of antigen uptake and presentation, and promoting antigen transport to draining lymph nodes. It appears that adjuvants activate innate immune responses to create a local immuno-competent environment at the injection site. Depending on the type of innate responses activated, adjuvants can alter the quality and quantity of adaptive immune responses. Understanding the mechanisms of action of adjuvants will provide critical information on how innate immunity influences the development of adaptive immunity, help in rational design of vaccines against various diseases, and can inform on adjuvant safety. PMID:23720661

  16. From affirmative action to affirming diversity.

    PubMed

    Thomas, R R

    1990-01-01

    Affirmative action is based on a set of 30-year-old premises that badly need revising. White males are no longer dominant at every level of the corporation (statistically, they are merely the largest of many minorities), while decades of attack have noticeably weakened racial and gender prejudices. At the intake level, affirmative action quite effectively sets the stage for a workplace that is gender-, culture-, and color-blind. But minorities and women tend to stagnate, plateau, or quit when they fail to move up the corporate ladder, and everyone's dashed hopes lead to corporate frustration and a period of embarrassed silence, usually followed by a crisis-and more recruitment. Some companies have repeated this cycle three or four times. The problem is that our traditional image of assimilating differences-the American melting pot-is no longer valid. It's a seller's market for skills, and the people business has to attract are refusing to be melted down. So companies are faced with the task of managing unassimilated diversity and getting from it the same commitment, quality, and profit they once got from a homogeneous work force. To reach this goal, we need to work not merely toward culture- and color-blindness but also toward an openly multicultural workplace that taps the full potential of every employee without artificial programs, standards, or barriers. The author gives his own ten guidelines for learning to manage diversity by learning to understand and modify your company's culture, vision, assumptions, models, and systems. PMID:10106515

  17. What are self-generated actions?

    PubMed

    Schüür, Friederike; Haggard, Patrick

    2011-12-01

    The concept of self-generated action is controversial, despite extensive study of its neural basis. Why is this concept so troublesome? We analyse the concept of self-generated action as employed by Passingham, Bengtsson, and Lau (2010a, 2010b). There are two definitions of self-generated action; as operant action and as underdetermined action. The latter draws on subjective experience. Experiments on action awareness suggest that experience may not be a good guide for defining self-generated action. Nevertheless, we agree with Passingham and colleagues that self-generated actions exist distinct from operant actions. But defining 'self-generated' by the degree of involvement of an endogenous process risks regress. We sketch an alternative account of self-generated action that tries to avoid these problems to make self-generated actions accessible to experimental science. PMID:21968149

  18. Corrective Action Plan for Corrective Action Unit 143: Area 25 Contaminated Waste Dumps, Nevada Test Site, Nevada

    SciTech Connect

    D. L. Gustafason

    2001-02-01

    This Corrective Action Plan (CAP) has been prepared for Corrective Action Unit (CAU) 143: Area 25 Contaminated Waste Dumps, Nevada Test Site, Nevada, in accordance with the Federal Facility Agreement and Consent Order of 1996. This CAP provides the methodology for implementing the approved corrective action alternative as listed in the Corrective Action Decision Document (U.S. Department of Energy, Nevada Operations Office, 2000). The CAU includes two Corrective Action Sites (CASs): 25-23-09, Contaminated Waste Dump Number 1; and 25-23-03, Contaminated Waste Dump Number 2. Investigation of CAU 143 was conducted in 1999. Analytes detected during the corrective action investigation were evaluated against preliminary action levels to determine constituents of concern for CAU 143. Radionuclide concentrations in disposal pit soil samples associated with the Reactor Maintenance, Assembly, and Disassembly Facility West Trenches, the Reactor Maintenance, Assembly, and Disassembly Facility East Trestle Pit, and the Engine Maintenance, Assembly, and Disassembly Facility Trench are greater than normal background concentrations. These constituents are identified as constituents of concern for their respective CASs. Closure-in-place with administrative controls involves use restrictions to minimize access and prevent unauthorized intrusive activities, earthwork to fill depressions to original grade, placing additional clean cover material over the previously filled portion of some of the trenches, and placing secondary or diversion berm around pertinent areas to divert storm water run-on potential.

  19. Action Research in Action: Curricular Articulation and Integrated Instruction.

    ERIC Educational Resources Information Center

    Arnold, Douglas E.

    1998-01-01

    During the 1995-96 school year, the author (a principal) and three teachers developed an action research project at a Virginia high school. The idea was to increase curricular articulation among departments and connections among disciplines (art, physics, and geometry) at the school. Teachers overcame two major barriers: lack of common planning…

  20. Its All Action, Its All Learning: Action Learning in SMEs

    ERIC Educational Resources Information Center

    Clarke, Jean; Thorpe, Richard; Anderson, Lisa; Gold, Jeff

    2006-01-01

    Purpose: The purpose of this paper is to argue that action learning (AL) may provide a means of successfully developing small to medium-sized enterprises (SMEs). Design/methodology/approach: The literature around SME learning suggests a number of processes are important for SME learning which similarity, it is argued, are encompassed in AL. AL may…