Sample records for action matrix summary

  1. 78 FR 11216 - Enforcement Actions Summary

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-15

    ...] Enforcement Actions Summary AGENCY: Transportation Security Administration, DHS. ACTION: Notice of... an annual summary of all enforcement actions taken by TSA under the authority granted in the... public with an annual summary of all enforcement actions taken by TSA under this subsection; and include...

  2. 77 FR 12865 - Enforcement Actions Summary

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-02

    ...] Enforcement Actions Summary AGENCY: Transportation Security Administration, DHS. ACTION: Notice of... an annual summary of all enforcement actions taken by TSA under the authority granted in the... public with an annual summary of all enforcement actions taken by TSA under this subsection; and include...

  3. 76 FR 9357 - Enforcement Actions Summary

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-17

    ...] Enforcement Actions Summary AGENCY: Transportation Security Administration, DHS. ACTION: Notice of... an annual summary of all enforcement actions taken by TSA under the authority granted in the... to provide the public with an annual summary of all enforcement actions taken by TSA under this...

  4. 9 CFR 4.10 - Summary action.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Summary action. 4.10 Section 4.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL... Practice § 4.10 Summary action. (a) In any situation where the Administrator has reason to believe that any...

  5. Department of Transportation Radionavigation Action Plan Summary

    DOT National Transportation Integrated Search

    1979-04-01

    The first issue by the Department of Transportation (DOT) of its Radionavigation Action Plan Summary is presented herein. The DOT Radionavigation Action Plan Summary describes major DOT activities and decisions relating to navigation through 1985. Th...

  6. Summary of Granulation Matrix Testing for the Plutonium Immobilization Program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Herman, C.C.

    2001-10-19

    In FY00, a matrix for process development testing was created to identify those items related to the ceramic process that had not been fully developed or tested and to help identify variables that needed to be tested. This matrix, NMTP/IP-99-003, was jointly created between LLNL and SRTC and was issued to all affected individuals. The matrix was also used to gauge the progress of the development activities. As part of this matrix, several series of tests were identified for the granulation process. This summary provides the data and results from the granulation testing. The results of the granulation matrix testingmore » were used to identify the baseline process for testing in the PuCTF with cold surrogates in B241 at LLNL.« less

  7. Summary data on all NASA procurement actions

    NASA Technical Reports Server (NTRS)

    1992-01-01

    This report presents summary data on all NASA procurement actions and detailed information on contracts, grants, agreements, and other procurements over $25,000 awarded by NASA during Fiscal Year 1992 (FY-92). The dollar value on procurements over $25,000 amounted to 97 percent of the total dollar value of procurement actions completed during FY-92. However, these larger procurements accounted for only 28 percent of the total actions. Procurement action, as used in this report, means contractual actions to obtain supplies, services, or construction which increase or decrease funds. A procurement action thus may be a new procurement or modifications such as supplemental agreements, change orders, or terminations to an existing contract that change the total amount of funds obligated. An obligation is a contractual commitment to pay for supplies or services that are specified in the contract.

  8. Summary data on all NASA procurement actions

    NASA Technical Reports Server (NTRS)

    1990-01-01

    Summary data on all NASA procurement actions and detailed information on contracts, grants, agreements, and other procurements over $25,000 awarded by NASA during the first six months on fiscal year 1990 are presented. Areas addressed include competition in NASA awards, awards to business firms, awards to educational and other nonprofit institutions, contract for operation of Jet Propulsion Laboratory, and awards through other government agencies. Other topics covered are the U.S. geographical distribution of awards, awards placed outside the U.S., and procurement activity by installation.

  9. Education issues in disaster medicine: summary and action plan.

    PubMed

    Armour, S J; Bastone, P; Birnbaum, M; Garrett, C; Greenough, P G; Manni, C; Ninomiya, N; Renderos, J; Rottman, S; Sahni, P; Shih, C L; Siegel, D; Younggren, B

    2001-01-01

    Change must begin with education. Theme 8 explored issues that need attention in Disaster Medicine education. Details of the methods used are provided in the introductory paper. The chairs moderated all presentations and produced a summary that was presented to an assembly of all of the delegates. The chairs then presided over a workshop that resulted in the generation of a set of action plans that then were reported to the collective group of all delegates. Main points developed during the presentations and discussion included: (1) formal education, (2) standardized definitions, (3) integration, (4) evaluation of programs and interventions, (5) international cooperation, (6) identifying the psychosocial consequences of disaster, (7) meaningful research, and (8) hazard, impact, risk and vulnerability analysis. Three main components of the action plans were identified as evaluation, research, and education. The action plans recommended that: (1) education on disasters should be formalized, (2) evaluation of education and interventions must be improved, and (3) meaningful research should be promulgated and published for use at multiple levels and that applied research techniques be the subject of future conferences. The one unanimous conclusion was that we need more and better education on the disaster phenomenon, both in its impacts and in our response to them. Such education must be increasingly evidence-based.

  10. Targeting extracellular matrix remodeling in disease: Could resveratrol be a potential candidate?

    PubMed

    Agarwal, Renu; Agarwal, Puneet

    2017-02-01

    Disturbances of extracellular matrix homeostasis are associated with a number of pathological conditions. The ability of extracellular matrix to provide contextual information and hence control the individual or collective cellular behavior is increasingly being recognized. Hence, newer therapeutic approaches targeting extracellular matrix remodeling are widely investigated. We reviewed the current literature showing the effects of resveratrol on various aspects of extracellular matrix remodeling. This review presents a summary of the effects of resveratrol on extracellular matrix deposition and breakdown. Mechanisms of action of resveratrol in extracellular matrix deposition involving growth factors and their signaling pathways are discussed. Involvement of phosphoinositol-3-kinase/Akt and mitogen-activated protein kinase pathways and role of transcription factors and sirtuins on the effects of resveratrol on extracellular matrix homeostasis are summarized. It is evident from the literature presented in this review that resveratrol has significant effects on both the synthesis and breakdown of extracellular matrix. The major molecular targets of the action of resveratrol are growth factors and their signaling pathways, phosphoinositol-3-kinase/Akt and mitogen-activated protein kinase pathways, transcription factors, and SIRT-1. The effects of resveratrol on extracellular matrix and the molecular targets appear to be related to experimental models, experimental environment as well as the doses.

  11. Targeting extracellular matrix remodeling in disease: Could resveratrol be a potential candidate?

    PubMed Central

    Agarwal, Puneet

    2016-01-01

    Disturbances of extracellular matrix homeostasis are associated with a number of pathological conditions. The ability of extracellular matrix to provide contextual information and hence control the individual or collective cellular behavior is increasingly being recognized. Hence, newer therapeutic approaches targeting extracellular matrix remodeling are widely investigated. We reviewed the current literature showing the effects of resveratrol on various aspects of extracellular matrix remodeling. This review presents a summary of the effects of resveratrol on extracellular matrix deposition and breakdown. Mechanisms of action of resveratrol in extracellular matrix deposition involving growth factors and their signaling pathways are discussed. Involvement of phosphoinositol-3-kinase/Akt and mitogen-activated protein kinase pathways and role of transcription factors and sirtuins on the effects of resveratrol on extracellular matrix homeostasis are summarized. It is evident from the literature presented in this review that resveratrol has significant effects on both the synthesis and breakdown of extracellular matrix. The major molecular targets of the action of resveratrol are growth factors and their signaling pathways, phosphoinositol-3-kinase/Akt and mitogen-activated protein kinase pathways, transcription factors, and SIRT-1. The effects of resveratrol on extracellular matrix and the molecular targets appear to be related to experimental models, experimental environment as well as the doses. PMID:27798117

  12. ClipCard: Sharable, Searchable Visual Metadata Summaries on the Cloud to Render Big Data Actionable

    NASA Astrophysics Data System (ADS)

    Saripalli, P.; Davis, D.; Cunningham, R.

    2013-12-01

    Research firm IDC estimates that approximately 90 percent of the Enterprise Big Data go un-analyzed, as 'dark data' - an enormous corpus of undiscovered, untagged information residing on data warehouses, servers and Storage Area Networks (SAN). In the geosciences, these data range from unpublished model runs to vast survey data assets to raw sensor data. Many of these are now being collected instantaneously, at a greater volume and in new data formats. Not all of these data can be analyzed, nor processed in real time, and their features may not be well described at the time of collection. These dark data are a serious data management problem for science organizations of all types, especially ones with mandated or required data reporting and compliance requirements. Additionally, data curators and scientists are encouraged to quantify the impact of their data holdings as a way to measure research success. Deriving actionable insights is the foremost goal of Big Data Analytics (BDA), which is especially true with geoscience, given its direct impact on most of the pressing global issues. Clearly, there is a pressing need for innovative approaches to making dark data discoverable, measurable, and actionable. We report on ClipCard, a Cloud-based SaaS analytic platform for instant summarization, quick search, visualization and easy sharing of metadata summaries form the Dark Data at hierarchical levels of detail, thus rendering it 'white', i.e., actionable. We present a use case of the ClipCard platform, a cloud-based application which helps generate (abstracted) visual metadata summaries and meta-analytics for environmental data at hierarchical scales within and across big data containers. These summaries and analyses provide important new tools for managing big data and simplifying collaboration through easy to deploy sharing APIs. The ClipCard application solves a growing data management bottleneck by helping enterprises and large organizations to summarize, search

  13. Sharing international experiences in disasters: summary and action plan.

    PubMed

    Andrews, R A; Austin, C; Brown, R; Chen, Y Z; Engindeniz, Z; Girouard, R; Leaman, P; Masellis, M; Nakayama, S; Polentsov, Y O; Suserud, B O

    2001-01-01

    The discussions in this theme provided an opportunity to share specific experiences with disasters that occurred outside of the Asia-Pacific Rim. Details of the methods used are provided in the preceding paper. The chairs moderated all presentations and produced a summary that was presented to an assembly of all of the delegates. Since the findings from the Theme 7 and Theme 3 groups were similar, the chairs of both groups presided over one workshop that resulted in the generation of a set of action plans that then were reported to the collective group of all delegates. The main points developed during the presentations and discussion included: (1) disaster response planning, (2) predetermined command and organizational structure, (3) rapid response capability, (4) mitigation, and (5) communications and alternatives. The action plans presented are in common with those presented by Theme 3, and include: (1) plan disaster responses including the different types, identification of hazards, training based on experiences, and provision of public education; (2) improving coordination and control; (3) maintaining communications assuming infrastructure breakdown; (4) maximizing mitigation through standardized evaluations, creation of a legal framework, and recognition of advocacy and public participation; and (5) providing resources and knowledge through access to existing therapies, using the media, and increasing decentralization of hospital inventories. Most of the problems that occurred outside the Asia-Pacific rim relative to disaster management are similar to those experienced within it. They should be addressed in common with the rest of the world.

  14. 41 CFR 60-2.31 - Program summary.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Program summary. 60-2.31...-AFFIRMATIVE ACTION PROGRAMS Miscellaneous § 60-2.31 Program summary. The affirmative action program must be summarized and updated annually. The program summary must be prepared in a format which will be prescribed by...

  15. Sharing Pacific-Rim experiences in disasters: summary and action plan.

    PubMed

    Arias, E H; Asai, Y; Chen, J C; Cheng, H K; Ishii, N; Kinugasa, T; Ko, P C; Koido, Y; Murayama, Y; Kwong, P W; Ukai, T

    2001-01-01

    The discussions in this theme provided an opportunity to address the unique hazards facing the Pacific Rim. Details of the methods used are provided in the preceding paper. The chairs moderated all presentations and produced a summary that was presented to an assembly of all of the delegates. Since the findings from the Theme 3 and Theme 7 groups were similar, the chairs of both groups presided over one workshop that resulted in the generation of a set of action plans that then were reported to the collective group of all delegates. The main points developed during the presentations and discussion included: (1) communication, (2) coordination, (3) advance planning and risk assessment, and (4) resources and knowledge. Action plans were summarized in the following ideas: (1) plan disaster responses including the different types, identification of hazards, focusing training based on experiences, and provision of public education; (2) improve coordination and control; (3) maintain communications, assuming infrastructure breakdown; (4) maximize mitigation through standardized evaluations, the creation of a legal framework, and recognition of advocacy and public participation; and (5) provide resources and knowledge through access to existing therapies, the media, and increasing and decentralizing hospital inventories. The problems in the Asia-Pacific rim are little different from those encountered elsewhere in the world. They should be addressed in common with the rest of the world.

  16. 41 CFR 60-30.23 - Summary judgment.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... time after the expiration of 20 days from the commencement of the action, or after service of a motion... after commencement of the action, move with or without supporting affidavits for summary judgment in its... part may support or oppose motions for summary judgment made by the Government or respondent, in...

  17. 41 CFR 60-30.23 - Summary judgment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... time after the expiration of 20 days from the commencement of the action, or after service of a motion... after commencement of the action, move with or without supporting affidavits for summary judgment in its... part may support or oppose motions for summary judgment made by the Government or respondent, in...

  18. 17 CFR 8.26 - Procedure for member responsibility actions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... EXCHANGE PROCEDURES FOR DISCIPLINARY, SUMMARY, AND MEMBERSHIP DENIAL ACTIONS Summary Actions § 8.26 Procedure for member responsibility actions. An action pursuant to § 8.25 shall be taken in accordance with... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Procedure for member...

  19. 75 FR 19672 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-15

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2010-15] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary petition...

  20. 78 FR 7477 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-01

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2012-56] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  1. 76 FR 24560 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-02

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2011-18] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  2. 78 FR 60996 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2013-48] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  3. 78 FR 59753 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-27

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2013-46] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  4. 78 FR 3068 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-15

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2012-54] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  5. 77 FR 71864 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-04

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2012-46] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  6. 76 FR 26335 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-06

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2011-19] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  7. 77 FR 54650 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-05

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2012-34] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  8. 78 FR 46672 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-01

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2013-30] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  9. 75 FR 15771 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-30

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2010-08] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  10. 77 FR 71865 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-04

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2012-51] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  11. 75 FR 80107 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-21

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2010-60] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  12. 76 FR 20806 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2011-16] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  13. 78 FR 53185 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-28

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2013-37] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  14. 76 FR 65772 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-24

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2011-48] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  15. 75 FR 60164 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-29

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2010-42] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  16. 76 FR 39975 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2011-29] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  17. 77 FR 13385 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-06

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2012-08] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  18. 76 FR 39976 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2011-30] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  19. 75 FR 76068 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2010-56] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  20. 77 FR 2120 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-13

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2012-02] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  1. 77 FR 54649 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-05

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2012-35] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  2. 78 FR 7851 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2012-57 ] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  3. 76 FR 14744 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-17

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2011-120] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  4. 75 FR 19459 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-14

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2010-13] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  5. 77 FR 71864 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-04

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2012-50] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  6. 76 FR 39976 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2011-32] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  7. 77 FR 71474 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-30

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2012-53] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  8. 75 FR 21388 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-23

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2010-14] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  9. 77 FR 13384 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-06

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2012-06] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  10. 78 FR 58599 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-24

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2013-42] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  11. 75 FR 47882 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-09

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2010-34] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  12. 78 FR 53185 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-28

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2013-41] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  13. 75 FR 80106 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-21

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2010-59] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  14. 78 FR 73918 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-09

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2013-58] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  15. 78 FR 21701 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-11

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2013-16] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  16. 78 FR 69930 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-21

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2013-56] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  17. 78 FR 67441 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2013-52] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  18. 76 FR 66351 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-26

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2011-48] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  19. 78 FR 57676 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-19

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2013-44] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  20. 75 FR 51164 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-18

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2010-35] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  1. 78 FR 60995 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2013-47] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  2. 78 FR 3068 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-15

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2012-60] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  3. 78 FR 36294 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-17

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2013-25] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  4. 78 FR 46673 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-01

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2013-33] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  5. 78 FR 13746 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2013-07] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  6. 75 FR 55394 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-10

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2010-40] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  7. 75 FR 19672 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-15

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2009-18] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  8. 78 FR 53186 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-28

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2013-40] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  9. 78 FR 21702 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-11

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2013-15] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  10. 75 FR 21387 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-23

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2010-20] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  11. 77 FR 29444 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-17

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2012-17] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  12. 77 FR 67438 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-09

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2012-46] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  13. 78 FR 68135 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-13

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2013-39] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  14. 77 FR 13384 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-06

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2012-07] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  15. 78 FR 13745 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2013-06] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  16. 77 FR 44309 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-27

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2012-27] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  17. 77 FR 29444 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-17

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2012-16] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  18. 75 FR 10342 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-05

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2010-06] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  19. 78 FR 67442 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2013-53] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  20. 78 FR 4190 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-18

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2012-63] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  1. 78 FR 21701 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-11

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2013-14] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  2. 78 FR 21702 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-11

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2013-02] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  3. 78 FR 46672 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-01

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2013-32] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition...

  4. 76 FR 80847 - Enforcement Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-27

    ... Enforcement Actions AGENCY: National Indian Gaming Commission, Interior. ACTION: Notice of proposed rulemaking. SUMMARY: This action proposes to amend NIGC regulations to include a graduated pre-enforcement process through which a tribe may come into compliance before an enforcement action is taken by the Chair...

  5. Affirmative Action in Other Lands: A Summary.

    ERIC Educational Resources Information Center

    Greenberg, Jack

    This paper briefly summarizes issues in affirmative action covered by the conference papers preceding it in the same volume. First, the definition of affirmative action adopted by the United Nations at an international convention in 1969 is reviewed. Based on this definition, the countries covered in the conference papers are classified as…

  6. 12 CFR 747.29 - Summary disposition.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ADMINISTRATIVE ACTIONS, ADJUDICATIVE HEARINGS, RULES OF PRACTICE AND PROCEDURE, AND INVESTIGATIONS Uniform Rules... shall recommend that the NCUA Board issue a final order granting a motion for summary disposition if the... motion for summary disposition show that: (1) There is no genuine issue as to any material fact; and (2...

  7. 78 FR 39824 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ...] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition... information in the summary is intended to affect the legal status of the petition or its final disposition...

  8. 78 FR 978 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-07

    ...] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition... information in the summary is intended to affect the legal status of the petition or its final disposition...

  9. 78 FR 17746 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-22

    ...] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition... information in the summary is intended to affect the legal status of the petition or its final disposition...

  10. 12 CFR 747.30 - Partial summary disposition.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ADMINISTRATIVE ACTIONS, ADJUDICATIVE HEARINGS, RULES OF PRACTICE AND PROCEDURE, AND INVESTIGATIONS Uniform Rules of Practice and Procedure § 747.30 Partial summary disposition. If the administrative law judge.... Those claims for which the administrative law judge has determined that summary disposition is warranted...

  11. 77 FR 47517 - Enforcement Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-09

    ... DEPARTMENT OF THE INTERIOR National Indian Gaming Commission 25 CFR Part 573 Enforcement Actions AGENCY: National Indian Gaming Commission. ACTION: Final rule. SUMMARY: The National Indian Gaming... be considered final agency action by a court even though it is issued by NIGC staff rather than the...

  12. "Built-In" Action/Issues Tracking and Post-Ops Analysis Tool for Realtime Console Operations

    NASA Technical Reports Server (NTRS)

    Scott, David W.

    2008-01-01

    Marshall Space Flight Center's (MSFC) Payload Operations Integration Center (POIC) for the International Space Station (ISS) uses a number of formal databases to manage and track flight plan changes, onboard and ground equipment anomalies, and other events. However, individual console positions encounter many action items and/or occurrences that don't fit neatly into the databases, and while console logs are comprehensive, manual or automated searches do not always yield consistent results. The Payload Communications Manager (PAYCOM) team, whose members speak directly with the ISS onboard crew with respect to NASA payload operations, has found a creative way to reformat a mandatory Daily Report to organize action items, standing reminders, significant events, and other comments. While the report keeps others appraised of PAYCOMs activities and issues of the moment, the format makes it easy to capture very brief summaries of the items in a "Roll Off Matrix", including start and stop dates, resolution, and possible applicability to future ops. The matrix provides accountability for all action items, gives direct insight into the issues surrounding various payloads and methods of dealing with them, yields indirect information on PAYCOM priorities and processes, and provides a roadmap that makes it easier to get back to extensive details if needed. This paper describes how the ISS PAYCOM Daily Report and Roll Off Matrix are organized, used, and inter-related to each other and the PAYCOM operations log. While the application is for a manned vehicle, the concepts could apply in a wide spectrum of operational settings.

  13. 76 FR 80846 - Definition of Enforcement Action

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-27

    ... Definition of Enforcement Action AGENCY: National Indian Gaming Commission, Interior. ACTION: Notice of proposed rulemaking. SUMMARY: This action proposes to amend NIGC regulations to include definitions for ``enforcement action''. The Indian Gaming Regulatory Act authorizes the NIGC to take certain actions in regard...

  14. 76 FR 40811 - Maneb; Tolerance Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-12

    ...; Tolerance Actions AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: EPA is... established a docket for this action under docket identification (ID) number EPA-HQ-OPP-2010-0327. All... . SUPPLEMENTARY INFORMATION: I. General Information A. Does this action apply to me? You may be potentially...

  15. 77 FR 31064 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ...] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition... the legal status of the petition or its final disposition. DATES: Comments on this petition must...

  16. 78 FR 53818 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-30

    ...] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition... the legal status of the petition or its final disposition. DATES: Comments on this petition must...

  17. 78 FR 24290 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-24

    ...] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition... the legal status of the petition or its final disposition. DATES: Comments on this petition must...

  18. 78 FR 17746 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-22

    ...] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition... the legal status of the petition or its final disposition. DATES: Comments on this petition must...

  19. 77 FR 36333 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-18

    ...] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition... the legal status of the petition or its final disposition. DATES: Comments on this petition must...

  20. 75 FR 20881 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ...] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition... the legal status of the petition or its final disposition. DATES: Comments on this petition must...

  1. 77 FR 58210 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-19

    ...] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition... the legal status of the petition or its final disposition. DATES: Comments on this petition must...

  2. 78 FR 35353 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-12

    ...] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition... the legal status of the petition or its final disposition. DATES: Comments on this petition must...

  3. 75 FR 60859 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-01

    ...] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition... the legal status of the petition or its final disposition. DATES: Comments on this petition must...

  4. 77 FR 35103 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-12

    ...] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition... the legal status of the petition or its final disposition. DATES: Comments on this petition must...

  5. 78 FR 56768 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-13

    ...] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition... the legal status of the petition or its final disposition. DATES: Comments on this petition must...

  6. 75 FR 26839 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ...] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition... the legal status of the petition or its final disposition. DATES: Comments on this petition must...

  7. 78 FR 66098 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ...] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition... the legal status of the petition or its final disposition. DATES: Comments on this petition must...

  8. 76 FR 9852 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-22

    ...] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition... the legal status of the petition or its final disposition. DATES: Comments on this petition must...

  9. 78 FR 978 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-07

    ...] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition... the legal status of the petition or its final disposition. DATES: Comments on this petition must...

  10. 76 FR 2746 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ...] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition... the legal status of the petition or its final disposition. DATES: Comments on this petition must...

  11. 78 FR 34139 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ...] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition... the legal status of the petition or its final disposition. DATES: Comments on this petition must...

  12. 76 FR 51119 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ...] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition... the legal status of the petition or its final disposition. DATES: Comments on this petition must...

  13. 78 FR 39825 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ...] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition... the legal status of the petition or its final disposition. DATES: Comments on this petition must...

  14. 78 FR 979 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-07

    ...] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice contains a summary of a petition... the legal status of the petition or its final disposition. DATES: Comments on this petition must...

  15. 78 FR 42071 - Updates to Protective Action Guides Manual: Protective Action Guides (PAGs) and Planning Guidance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-15

    ... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OAR-2007-0268; FRL-9833-5] Updates to Protective Action Guides Manual: Protective Action Guides (PAGs) and Planning Guidance for Radiological Incidents AGENCY: Environmental Protection Agency (EPA). ACTION: Proposed guidance; extension of comment period. SUMMARY: The U.S...

  16. 77 FR 38296 - Draft Public Health Action Plan-A National Public Health Action Plan for the Detection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-27

    ...-2012-0004] Draft Public Health Action Plan--A National Public Health Action Plan for the Detection...), Department of Health and Human Services (HHS). ACTION: Extension of public comment period. SUMMARY: On May 16... National Public Health Action Plan for the Detection, Prevention, and Management of Infertility (77 FR...

  17. Regularized matrix regression

    PubMed Central

    Zhou, Hua; Li, Lexin

    2014-01-01

    Summary Modern technologies are producing a wealth of data with complex structures. For instance, in two-dimensional digital imaging, flow cytometry and electroencephalography, matrix-type covariates frequently arise when measurements are obtained for each combination of two underlying variables. To address scientific questions arising from those data, new regression methods that take matrices as covariates are needed, and sparsity or other forms of regularization are crucial owing to the ultrahigh dimensionality and complex structure of the matrix data. The popular lasso and related regularization methods hinge on the sparsity of the true signal in terms of the number of its non-zero coefficients. However, for the matrix data, the true signal is often of, or can be well approximated by, a low rank structure. As such, the sparsity is frequently in the form of low rank of the matrix parameters, which may seriously violate the assumption of the classical lasso. We propose a class of regularized matrix regression methods based on spectral regularization. A highly efficient and scalable estimation algorithm is developed, and a degrees-of-freedom formula is derived to facilitate model selection along the regularization path. Superior performance of the method proposed is demonstrated on both synthetic and real examples. PMID:24648830

  18. 78 FR 18420 - Special Permit Applications Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... Applications Actions AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice of actions on special permit applications. SUMMARY: In accordance with the procedures governing... Hazardous Material Regulations (49 CFR part 107, subpart B), notice is hereby given of the actions on...

  19. Weldon Spring Site Remedial Action Project Federal Facilities Agreement: Quarterly environmental data summary for third quarter 1998

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1998-11-06

    In support of the Weldon Spring Site Remedial Action Project Federal Facilities Agreement, a copy of the Quarterly Environmental Data Summary (QEDS) for the third quarter of 1998 is enclosed. The data presented in this letter and attachment constitute the QEDS. The data, except for air monitoring data and site KPA generated data (uranium analyses), were received from the contract laboratories, verified by the Weldon Spring Site verification group, and merged into the database during the third quarter of 1998. Air monitoring data presented are the most recent complete sets of quarterly data. Significant data, defined as data values thatmore » have exceeded defined above normal Level 2 values, are discussed in this letter for Environmental Monitoring Plan (EMP) generated data only. Above normal Level 2 values are based, in ES and H procedures, on historical high values, DOE Derived Concentration Guides (DCGs), NPDES limits, and other guidelines. The procedures also establish actions to be taken in the event that above normal data occur.« less

  20. 77 FR 47513 - Definition of Enforcement Action

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-09

    ... Enforcement Action AGENCY: National Indian Gaming Commission, Interior. ACTION: Final rule. SUMMARY: The... to add a definition of ``enforcement action.'' DATES: Effective Date: September 10, 2012. FOR FURTHER... that to supplement the amendments made to Part 573, a definition of ``enforcement action'' needed to be...

  1. 76 FR 78945 - Summary of Commission Practice Relating to Administrative Protective Orders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ... INTERNATIONAL TRADE COMMISSION Summary of Commission Practice Relating to Administrative Protective Orders AGENCY: U.S. International Trade Commission. ACTION: Summary of Commission practice relating to administrative protective orders. SUMMARY: Since February 1991, the U.S. International Trade...

  2. 75 FR 66127 - Summary of Commission Practice Relating to Administrative Protective Orders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-27

    ... INTERNATIONAL TRADE COMMISSION Summary of Commission Practice Relating to Administrative Protective Orders AGENCY: U.S. International Trade Commission. ACTION: Summary of Commission practice relating to administrative protective orders. SUMMARY: Since February 1991, the U.S. International Trade...

  3. 77 FR 58213 - Actions on Special Permit Applications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-19

    ... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration Actions on.... ACTION: Notice of actions on Special Permit Applications. SUMMARY: In accordance with the procedures... actions on special permits applications in (August to August 2012). The mode of transportation involved...

  4. Faces of matrix models

    NASA Astrophysics Data System (ADS)

    Morozov, A.

    2012-08-01

    Partition functions of eigenvalue matrix models possess a number of very different descriptions: as matrix integrals, as solutions to linear and nonlinear equations, as τ-functions of integrable hierarchies and as special-geometry prepotentials, as result of the action of W-operators and of various recursions on elementary input data, as gluing of certain elementary building blocks. All this explains the central role of such matrix models in modern mathematical physics: they provide the basic "special functions" to express the answers and relations between them, and they serve as a dream model of what one should try to achieve in any other field.

  5. Curvature and gravity actions for matrix models: II. The case of general Poisson structures

    NASA Astrophysics Data System (ADS)

    Blaschke, Daniel N.; Steinacker, Harold

    2010-12-01

    We study the geometrical meaning of higher order terms in matrix models of Yang-Mills type in the semi-classical limit, generalizing recent results (Blaschke and Steinacker 2010 Class. Quantum Grav. 27 165010 (arXiv:1003.4132)) to the case of four-dimensional spacetime geometries with general Poisson structure. Such terms are expected to arise e.g. upon quantization of the IKKT-type models. We identify terms which depend only on the intrinsic geometry and curvature, including modified versions of the Einstein-Hilbert action as well as terms which depend on the extrinsic curvature. Furthermore, a mechanism is found which implies that the effective metric G on the spacetime brane {\\cal M}\\subset \\mathds{R}^D 'almost' coincides with the induced metric g. Deviations from G = g are suppressed, and characterized by the would-be U(1) gauge field.

  6. Manned space programs accident/incident summaries (1963 - 1969)

    NASA Technical Reports Server (NTRS)

    1970-01-01

    This summary is a compilation of 508 mishaps assembled from company and NASA records which cover several years of manned space flight activity. The purpose is to provide information to be applied towards accident prevention. The accident/incident summaries are categorized by the following ten systems: cryogenic; electrical; facility/GSE; fuel and propellant; life support; ordnance; pressure; propulsion; structural; and transport/handling. Each accident/incident summary has been summarized by description, cause and recommended preventive action.

  7. 77 FR 64843 - Actions on Special Permit Applications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration Actions on.... ACTION: Notice of actions on Special Permit Applications. SUMMARY: In accordance with the procedures...'s Hazardous Material Regulations (49 CFR part 107, subpart B), notice is hereby given of the actions...

  8. 78 FR 24305 - Actions on Special Permit Applications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-24

    ... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration Actions on.... ACTION: Notice of actions on Special Permit Applications. SUMMARY: In accordance with the procedures...'s Hazardous Material Regulations (49 CFR Part 107, Subpart B), notice is hereby given of the actions...

  9. 77 FR 49483 - Actions on Special Permit Applications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-16

    ... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration Actions on.... ACTION: Notice of actions on Special Permit Applications. SUMMARY: In accordance with the procedures...'s Hazardous Material Regulations (49 CFR Part 107, Subpart B), notice is hereby given of the actions...

  10. 78 FR 30394 - Actions on Special Permit Applications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration Actions on.... ACTION: Notice of actions on Special Permit Applications. SUMMARY: In accordance with the procedures...'s Hazardous Material Regulations (49 CFR part 107, subpart B), notice is hereby given of the actions...

  11. 77 FR 42360 - Actions on Special Permit Applications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-18

    ... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration Actions on... Safety Administration (PHMSA), DOT. ACTION: Notice of actions on Special Permit Applications. SUMMARY: In... given of the actions on special permits applications in (June to June 2012). The mode of transportation...

  12. 77 FR 29450 - Actions on Special Permit Applications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-17

    ... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration Actions on.... ACTION: Notice of actions on Special Permit Applications. SUMMARY: In accordance with the procedures...'s Hazardous Material Regulations (49 CFR part 107, subpart B), notice is hereby given of the actions...

  13. 78 FR 69140 - CSMI, LLC; Request for Action

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-18

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2013-0250] CSMI, LLC; Request for Action AGENCY: Nuclear Regulatory Commission. ACTION: Request for action; receipt. SUMMARY: The U.S. Nuclear Regulatory... petitioner) has requested that the NRC take action with regard to CSMI. The petitioner's requests are...

  14. Chapter 1 In Action. Virginia Evaluation Summary, 1979-83.

    ERIC Educational Resources Information Center

    Hill, Macio H.

    This booklet summarizes evaluation information from the first year of Chapter 1 programs (funded under the Education Consolidation and Improvement Act of 1981) in Virginia, and presents highlights from the last 18 years of the Title I program (funded under the Elementary and Secondary Education Act). The summary, which reflects the results of…

  15. INFORMAS (International Network for Food and Obesity/non-communicable diseases Research, Monitoring and Action Support): summary and future directions.

    PubMed

    Kumanyika, S

    2013-10-01

    This supplement presents the foundational elements for INFORMAS (International Network for Food and Obesity/non-communicable diseases Research, Monitoring and Action Support). As explained in the overview article by Swinburn and colleagues, INFORMAS has a compelling rationale and has set forth clear objectives, outcomes, principles and frameworks for monitoring and benchmarking key aspects of food environments and the policies and actions that influence the healthiness of food environments. This summary highlights the proposed monitoring approaches for the 10 interrelated INFORMAS modules: public and private sector policies and actions; key aspects of food environments (food composition, labelling, promotion, provision, retail, prices, and trade and investment) and population outcomes (diet quality). This ambitious effort should be feasible when approached in a step-wise manner, taking into account existing monitoring efforts, data sources, country contexts and capacity, and when adequately resourced. After protocol development and pilot testing of the modules, INFORMAS aims to be a sustainable, low-cost monitoring framework. Future directions relate to institutionalization, implementation and, ultimately, to leveraging INFORMAS data in ways that will bring key drivers of food environments into alignment with public health goals. © 2013 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of the International Association for the Study of Obesity.

  16. BSR: B-spline atomic R-matrix codes

    NASA Astrophysics Data System (ADS)

    Zatsarinny, Oleg

    2006-02-01

    BSR is a general program to calculate atomic continuum processes using the B-spline R-matrix method, including electron-atom and electron-ion scattering, and radiative processes such as bound-bound transitions, photoionization and polarizabilities. The calculations can be performed in LS-coupling or in an intermediate-coupling scheme by including terms of the Breit-Pauli Hamiltonian. New version program summaryTitle of program: BSR Catalogue identifier: ADWY Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADWY Program obtainable from: CPC Program Library, Queen's University of Belfast, N. Ireland Computers on which the program has been tested: Microway Beowulf cluster; Compaq Beowulf cluster; DEC Alpha workstation; DELL PC Operating systems under which the new version has been tested: UNIX, Windows XP Programming language used: FORTRAN 95 Memory required to execute with typical data: Typically 256-512 Mwords. Since all the principal dimensions are allocatable, the available memory defines the maximum complexity of the problem No. of bits in a word: 8 No. of processors used: 1 Has the code been vectorized or parallelized?: no No. of lines in distributed program, including test data, etc.: 69 943 No. of bytes in distributed program, including test data, etc.: 746 450 Peripherals used: scratch disk store; permanent disk store Distribution format: tar.gz Nature of physical problem: This program uses the R-matrix method to calculate electron-atom and electron-ion collision processes, with options to calculate radiative data, photoionization, etc. The calculations can be performed in LS-coupling or in an intermediate-coupling scheme, with options to include Breit-Pauli terms in the Hamiltonian. Method of solution: The R-matrix method is used [P.G. Burke, K.A. Berrington, Atomic and Molecular Processes: An R-Matrix Approach, IOP Publishing, Bristol, 1993; P.G. Burke, W.D. Robb, Adv. At. Mol. Phys. 11 (1975) 143; K.A. Berrington, W.B. Eissner, P.H. Norrington, Comput

  17. 75 FR 81287 - Mortgagee Review Board: Administrative Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-27

    ...: Administrative Actions AGENCY: Office of the Assistant Secretary for Housing--Federal Housing Commissioner, Department of Housing and Urban Development (HUD). ACTION: Notice. SUMMARY: In compliance with Section 202(c... actions taken by HUD's Mortgagee Review Board against HUD-approved mortgagees. FOR FURTHER INFORMATION...

  18. 75 FR 3479 - Mortgagee Review Board: Administrative Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ...: Administrative Actions AGENCY: Office of the Assistant Secretary for Housing-Federal Housing Commissioner, Department of Housing and Urban Development (HUD). ACTION: Notice. SUMMARY: In compliance with Section 202(c... actions taken by HUD's Mortgagee Review Board against HUD-approved mortgagees. FOR FURTHER INFORMATION...

  19. 77 FR 11149 - Mortgagee Review Board: Administrative Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-24

    ...: Administrative Actions AGENCY: Office of the Assistant Secretary for Housing--Federal Housing Commissioner, Department of Housing and Urban Development (HUD). ACTION: Notice. SUMMARY: In compliance with Section 202(c... actions taken by HUD's Mortgagee Review Board against HUD-approved mortgagees. FOR FURTHER INFORMATION...

  20. 33 CFR 153.415 - Cost summary reports.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) POLLUTION CONTROL OF POLLUTION BY OIL AND HAZARDOUS SUBSTANCES, DISCHARGE REMOVAL Administration of the Pollution Fund § 153.415 Cost summary reports. As soon as practicable after completion of an action...

  1. 33 CFR 153.415 - Cost summary reports.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) POLLUTION CONTROL OF POLLUTION BY OIL AND HAZARDOUS SUBSTANCES, DISCHARGE REMOVAL Administration of the Pollution Fund § 153.415 Cost summary reports. As soon as practicable after completion of an action...

  2. 33 CFR 153.415 - Cost summary reports.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) POLLUTION CONTROL OF POLLUTION BY OIL AND HAZARDOUS SUBSTANCES, DISCHARGE REMOVAL Administration of the Pollution Fund § 153.415 Cost summary reports. As soon as practicable after completion of an action...

  3. 33 CFR 153.415 - Cost summary reports.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) POLLUTION CONTROL OF POLLUTION BY OIL AND HAZARDOUS SUBSTANCES, DISCHARGE REMOVAL Administration of the Pollution Fund § 153.415 Cost summary reports. As soon as practicable after completion of an action...

  4. 33 CFR 153.415 - Cost summary reports.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) POLLUTION CONTROL OF POLLUTION BY OIL AND HAZARDOUS SUBSTANCES, DISCHARGE REMOVAL Administration of the Pollution Fund § 153.415 Cost summary reports. As soon as practicable after completion of an action...

  5. Stage-Specific Action of Matrix Metalloproteinases Influences Progressive Hereditary Kidney Disease

    PubMed Central

    Zeisberg, Michael; Khurana, Mona; Rao, Velidi H; Cosgrove, Dominic; Rougier, Jean-Philippe; Werner, Michelle C; Shield, Charles F; Werb, Zena; Kalluri, Raghu

    2006-01-01

    Background Glomerular basement membrane (GBM), a key component of the blood-filtration apparatus in the in the kidney, is formed through assembly of type IV collagen with laminins, nidogen, and sulfated proteoglycans. Mutations or deletions involving α3(IV), α4(IV), or α5(IV) chains of type IV collagen in the GBM have been identified as the cause for Alport syndrome in humans, a progressive hereditary kidney disease associated with deafness. The pathological mechanisms by which such mutations lead to eventual kidney failure are not completely understood. Methods and Findings We showed that increased susceptibility of defective human Alport GBM to proteolytic degradation is mediated by three different matrix metalloproteinases (MMPs)—MMP-2, MMP-3, and MMP-9—which influence the progression of renal dysfunction in α3(IV) −/− mice, a model for human Alport syndrome. Genetic ablation of either MMP-2 or MMP-9, or both MMP-2 and MMP-9, led to compensatory up-regulation of other MMPs in the kidney glomerulus. Pharmacological ablation of enzymatic activity associated with multiple GBM-degrading MMPs, before the onset of proteinuria or GBM structural defects in the α3(IV) −/− mice, led to significant attenuation in disease progression associated with delayed proteinuria and marked extension in survival. In contrast, inhibition of MMPs after induction of proteinuria led to acceleration of disease associated with extensive interstitial fibrosis and early death of α3(IV) −/− mice. Conclusions These results suggest that preserving GBM/extracellular matrix integrity before the onset of proteinuria leads to significant disease protection, but if this window of opportunity is lost, MMP-inhibition at the later stages of Alport disease leads to accelerated glomerular and interstitial fibrosis. Our findings identify a crucial dual role for MMPs in the progression of Alport disease in α3(IV) −/− mice, with an early pathogenic function and a later protective

  6. 76 FR 45594 - Mortgagee Review Board: Administrative Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-29

    ...: Administrative Actions AGENCY: Office of the Assistant Secretary for Housing--Federal Housing Commissioner, HUD. ACTION: Notice. SUMMARY: In compliance with Section 202(c)(5) of the National Housing Act, this notice advises of the cause and describes the administrative actions taken by HUD's Mortgagee Review Board...

  7. Analysis of Nonlinear Dynamics by Square Matrix Method

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yu, Li Hua

    The nonlinear dynamics of a system with periodic structure can be analyzed using a square matrix. In this paper, we show that because the special property of the square matrix constructed for nonlinear dynamics, we can reduce the dimension of the matrix from the original large number for high order calculation to low dimension in the first step of the analysis. Then a stable Jordan decomposition is obtained with much lower dimension. The transformation to Jordan form provides an excellent action-angle approximation to the solution of the nonlinear dynamics, in good agreement with trajectories and tune obtained from tracking. Andmore » more importantly, the deviation from constancy of the new action-angle variable provides a measure of the stability of the phase space trajectories and their tunes. Thus the square matrix provides a novel method to optimize the nonlinear dynamic system. The method is illustrated by many examples of comparison between theory and numerical simulation. Finally, in particular, we show that the square matrix method can be used for optimization to reduce the nonlinearity of a system.« less

  8. Matrix Training of Preliteracy Skills with Preschoolers with Autism

    ERIC Educational Resources Information Center

    Axe, Judah B.; Sainato, Diane M.

    2010-01-01

    Matrix training is a generative approach to instruction in which words are arranged in a matrix so that some multiword phrases are taught and others emerge without direct teaching. We taught 4 preschoolers with autism to follow instructions to perform action-picture combinations (e.g., circle the pepper, underline the deer). Each matrix contained…

  9. The extracellular matrix remodeled

    PubMed Central

    Kirmse, Robert; Otto, Hannes

    2012-01-01

    Membrane Type-1 Matrix Metalloproteinase (MT1-MMP, MMP-14) is regarded as the prototype of a membrane- tethered protease. It drives fundamental biological processes ranging from embryogenesis to cancer metastasis. The proteolytic cleavage of proteins by MT1-MMP can rapidly alter the biophysical properties of a cell’s microenvironment. Cell’s must thus be able to sense and react to these alterations and transduce these effectively in biochemical signals and cell responses. Although many cells react as acutely to such physical stimuli as they do to chemical ones, the regulatory effects of these have been less extensively explored. In order to investigate a possible interdependency of proteolytic matrix cleavage by MT1-MMP and the generation and sensing of force by cells, a model system was established which exploits the properties of a matrix array of parallel collagen-I fibers. The resulting an-isotropy of the matrix with high tensile strength along the fibers and high mobility perpendicular to it allows the convenient detection of bundling and cleavage of the collagen fibers, as well as spreading and durotaxis of the cells. In summary, we have demonstrated that cell adhesion, force generation, and force sensing are vital for the regulation of MT1-MMP for efficient cleavage of collagen-I. PMID:22482015

  10. Do clinicians want recommendations? A multi-center study comparing evidence summaries with and without GRADE recommendations.

    PubMed

    Neumann, Ignacio; Alonso-Coello, Pablo; Vandvik, Per Olav; Agoritsas, Thomas; Mas, Gemma; Akl, Elie A; Brignardello-Petersen, Romina; Emparanza, Jose; McCullagh, Lauren; De Sitio, Catherine; McGinn, Thomas; Almodaimegh, Hind; Almodaimegh, Khalid; Rivera, Solange; Rojas, Luis; Stirnemann, Jérôme; Irani, Jihad; Hlais, Sani; Mustafa, Reem; Bdair, Fadi; Aly, Abdelrahman; Kristiansen, Annette; Izcovich, Ariel; Ramirez, Anggie; Brozek, Jan; Guyatt, Gordon; Schünemann, Holger J

    2018-03-09

    Evidence-based clinical practice guidelines provide recommendations to assist clinicians in decision-making and to reduce the gap between best current research evidence and clinical practice. However, some argue that providing pre-appraised evidence summaries alone, rather than recommendations, is more appropriate. To evaluate clinicians' preferences, understanding of the evidence and intended course of action in response to evidence summaries with and without recommendations. We included practicing clinicians attending educational sessions across 10 countries. Clinicians were randomized to receive relevant clinical scenarios supported by research evidence of low or very-low certainty, and accompanied by either strong or weak recommendations developed with the GRADE system. Within each group, participants were further randomized to receive the recommendation plus the corresponding evidence summary or the evidence summary alone. We evaluated participants' preferences and understanding for the presentation strategy as well as their intended course of action. 189/219 (86%) and 201/248 (81%) participants preferred having recommendations accompanying evidence summaries for both strong and weak recommendations, respectively. Across all scenarios less than half of participants correctly interpreted information provided in the evidences summaries (e.g. estimates of effect, certainty in the research evidence). Presence of a recommendation resulted in a more appropriate intended course of action for two scenarios involving strong recommendations. Evidence summaries alone are not enough to impact clinicians' course of action. Clinicians clearly prefer having recommendations accompanying evidence summaries in the context of low or very-low certainty of evidence (Trial registration NCT02006017). Copyright © 2018 Elsevier Inc. All rights reserved.

  11. Guidelines On The Use Of Changeable Message Signs - Summary Report

    DOT National Transportation Integrated Search

    1991-05-01

    ">THIS SUMMARY REPORT FOCUSES ON MATRIX-TYPE CMSS, WITH PARTICULAR ATTENTION TO THE NEWER LIGHT-EMITTING SIGNS. ALTHOUGH THERE ARE MANY TYPES OF NEW AND EMERGING CMSS TECHNOLOGIES, CMSS THAT HAVE ACTUALLY BEEN INSTALLED FOR HIGHWAY APPLICATIONS ARE E...

  12. FPGA-based coprocessor for matrix algorithms implementation

    NASA Astrophysics Data System (ADS)

    Amira, Abbes; Bensaali, Faycal

    2003-03-01

    Matrix algorithms are important in many types of applications including image and signal processing. These areas require enormous computing power. A close examination of the algorithms used in these, and related, applications reveals that many of the fundamental actions involve matrix operations such as matrix multiplication which is of O (N3) on a sequential computer and O (N3/p) on a parallel system with p processors complexity. This paper presents an investigation into the design and implementation of different matrix algorithms such as matrix operations, matrix transforms and matrix decompositions using an FPGA based environment. Solutions for the problem of processing large matrices have been proposed. The proposed system architectures are scalable, modular and require less area and time complexity with reduced latency when compared with existing structures.

  13. Tetracycline compounds with non-antimicrobial organ protective properties: possible mechanisms of action

    PubMed Central

    Griffin, Michael O.; Ceballos, Guillermo; Villarreal, Francisco

    2010-01-01

    Tetracyclines were developed as a result of the screening of soil samples for antibiotics. The firstt of these compounds, chlortetracycline, was introduced in 1947. Tetracyclines were found to be highly effective against various pathogens including rickettsiae, as well as both gram-positive and gram-negative bacteria, thus becoming the first class of broad spectrum antibiotics. Many other interesting properties, unrelated to their antibiotic activity, have been identified for tetracyclines which have led to widely divergent experimental and clinical uses. For example, tetracyclines are also an effective anti-malarial drug. Minocycline, which can readily cross cell membranes, is known to be a potent anti-apoptotic agent. Another tetracycline, doxycycline is known to exert anti-protease activities. Doxycycline can inhibit matrix metalloproteinases which contribute to tissue destruction activities in diseases such as periodontitis. A large body of literature has provided additional evidence for the “beneficial” actions of tetracyclines, including their ability to act as reactive oxygen species scavengers and anti-inflammatory agents. This review provides a summary of tetracycline’s multiple mechanisms of action as a means to understand their beneficial effects. PMID:20951211

  14. Summary Report of Depleted Uranium (DU) Survey Actions at Nevada Test and Training Range (NTTR), Airspace Region 63B, Active Target Complex 10 (63-10)

    DTIC Science & Technology

    2016-09-15

    currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) 15 Sep 2016 2. REPORT TYPE...Consultative Letter 3. DATES COVERED (From – To) Feb – Jun 2013 4. TITLE AND SUBTITLE Summary Report of Depleted Uranium (DU) Survey Actions at...USAF RADIOISOTOPE COMMITTEE SECRETARIAT ATTN: DR. RAMACHANDRA BHAT 7700 ARLINGTON BLVD, STE 5151 FALLS CHURCH, VA 22042-5151

  15. Extended Krylov subspaces approximations of matrix functions. Application to computational electromagnetics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Druskin, V.; Lee, Ping; Knizhnerman, L.

    There is now a growing interest in the area of using Krylov subspace approximations to compute the actions of matrix functions. The main application of this approach is the solution of ODE systems, obtained after discretization of partial differential equations by method of lines. In the event that the cost of computing the matrix inverse is relatively inexpensive, it is sometimes attractive to solve the ODE using the extended Krylov subspaces, originated by actions of both positive and negative matrix powers. Examples of such problems can be found frequently in computational electromagnetics.

  16. Essential Oils in Food Preservation: Mode of Action, Synergies, and Interactions with Food Matrix Components

    PubMed Central

    Hyldgaard, Morten; Mygind, Tina; Meyer, Rikke Louise

    2012-01-01

    Essential oils are aromatic and volatile liquids extracted from plants. The chemicals in essential oils are secondary metabolites, which play an important role in plant defense as they often possess antimicrobial properties. The interest in essential oils and their application in food preservation has been amplified in recent years by an increasingly negative consumer perception of synthetic preservatives. Furthermore, food-borne diseases are a growing public health problem worldwide, calling for more effective preservation strategies. The antibacterial properties of essential oils and their constituents have been documented extensively. Pioneering work has also elucidated the mode of action of a few essential oil constituents, but detailed knowledge about most of the compounds’ mode of action is still lacking. This knowledge is particularly important to predict their effect on different microorganisms, how they interact with food matrix components, and how they work in combination with other antimicrobial compounds. The main obstacle for using essential oil constituents as food preservatives is that they are most often not potent enough as single components, and they cause negative organoleptic effects when added in sufficient amounts to provide an antimicrobial effect. Exploiting synergies between several compounds has been suggested as a solution to this problem. However, little is known about which interactions lead to synergistic, additive, or antagonistic effects. Such knowledge could contribute to design of new and more potent antimicrobial blends, and to understand the interplay between the constituents of crude essential oils. The purpose of this review is to provide an overview of current knowledge about the antibacterial properties and antibacterial mode of action of essential oils and their constituents, and to identify research avenues that can facilitate implementation of essential oils as natural preservatives in foods. PMID:22291693

  17. Essential oils in food preservation: mode of action, synergies, and interactions with food matrix components.

    PubMed

    Hyldgaard, Morten; Mygind, Tina; Meyer, Rikke Louise

    2012-01-01

    Essential oils are aromatic and volatile liquids extracted from plants. The chemicals in essential oils are secondary metabolites, which play an important role in plant defense as they often possess antimicrobial properties. The interest in essential oils and their application in food preservation has been amplified in recent years by an increasingly negative consumer perception of synthetic preservatives. Furthermore, food-borne diseases are a growing public health problem worldwide, calling for more effective preservation strategies. The antibacterial properties of essential oils and their constituents have been documented extensively. Pioneering work has also elucidated the mode of action of a few essential oil constituents, but detailed knowledge about most of the compounds' mode of action is still lacking. This knowledge is particularly important to predict their effect on different microorganisms, how they interact with food matrix components, and how they work in combination with other antimicrobial compounds. The main obstacle for using essential oil constituents as food preservatives is that they are most often not potent enough as single components, and they cause negative organoleptic effects when added in sufficient amounts to provide an antimicrobial effect. Exploiting synergies between several compounds has been suggested as a solution to this problem. However, little is known about which interactions lead to synergistic, additive, or antagonistic effects. Such knowledge could contribute to design of new and more potent antimicrobial blends, and to understand the interplay between the constituents of crude essential oils. The purpose of this review is to provide an overview of current knowledge about the antibacterial properties and antibacterial mode of action of essential oils and their constituents, and to identify research avenues that can facilitate implementation of essential oils as natural preservatives in foods.

  18. From the quantum transfer matrix to the quench action: the Loschmidt echo in XXZ Heisenberg spin chains

    NASA Astrophysics Data System (ADS)

    Piroli, Lorenzo; Pozsgay, Balázs; Vernier, Eric

    2017-02-01

    We consider the computation of the Loschmidt echo after quantum quenches in the interacting XXZ Heisenberg spin chain both for real and imaginary times. We study two-site product initial states, focusing in particular on the Néel and tilted Néel states. We apply the quantum transfer matrix (QTM) approach to derive generalized TBA equations, which follow from the fusion hierarchy of the appropriate QTM’s. Our formulas are valid for arbitrary imaginary time and for real times at least up to a time t 0, after which the integral equations have to be modified. In some regimes, t 0 is seen to be either very large or infinite, allowing to explore in detail the post-quench dynamics of the system. As an important part of our work, we show that for the Néel state our imaginary time results can be recovered by means of the quench action approach, unveiling a direct connection with the quantum transfer matrix formalism. In particular, we show that in the zero-time limit, the study of our TBA equations allows for a simple alternative derivation of the recently obtained Bethe ansatz distribution functions for the Néel, tilted Néel and tilted ferromagnet states.

  19. 76 FR 48807 - Public Key Infrastructure (PKI) Certificate Action Form

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-09

    ...) Certificate Action Form ACTION: Proposed collection; comment request. SUMMARY: The United States Patent and... Certificate Action Form (PTO-2042), which is used by the public to request a new digital certificate, the... applicant. The Certificate Action Form has an accompanying subscriber agreement to ensure that customers...

  20. Summary of State Legislation Affecting Higher Education in the West: 1969.

    ERIC Educational Resources Information Center

    Snyder, Patricia, Ed.

    This report is designed to provide an interpretive summary of 1969 state legislative actions in the West that affected higher education. After a regional summary, both brief and extended analyses are provided of legislation in Alaska, Arizona, California, Colorado, Hawaii, Idaho, Montana, Nevada, New Mexico, Oregon, Utah, Washington, and Wyoming.…

  1. 76 FR 34120 - Action Subject to Intergovernmental Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-10

    ... SMALL BUSINESS ADMINISTRATION Action Subject to Intergovernmental Review AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: Under Executive Order 12372, the Small Business Administration (SBA) is notifying the public that it intends to grant the pending applications of 39 existing...

  2. 76 FR 34119 - Action Subject to Intergovernmental Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-10

    ... SMALL BUSINESS ADMINISTRATION Action Subject to Intergovernmental Review AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: Under Executive Order 12372, the Small Business Administration (SBA) is notifying the public that it intends to grant the pending applications of 22 existing...

  3. Energy and Environment Guide to Action- Executive Summary

    EPA Pesticide Factsheets

    Summarizes the key messages and purpose of the Energy and Environment Guide to Action, which describes the latest best practices and opportunities that states are using to invest in energy efficiency, renewable energy, and CHP.

  4. 77 FR 19050 - Actions Taken at December 15, 2011, Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-29

    ... SUSQUEHANNA RIVER BASIN COMMISSION Actions Taken at December 15, 2011, Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: As part of its regular business meeting held on... took the following actions: (1) Rescinded approval for three water resources projects; and (2) approved...

  5. 78 FR 2313 - Actions Taken at December 14, 2012, Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-10

    ... SUSQUEHANNA RIVER BASIN COMMISSION Actions Taken at December 14, 2012, Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: As part of its regular business meeting held on December 14, 2012, in Annapolis, Maryland, the Commission took the following actions: (1) Approved...

  6. 76 FR 62142 - Actions Taken at September 15, 2011, Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-06

    ... SUSQUEHANNA RIVER BASIN COMMISSION Actions Taken at September 15, 2011, Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: As part of its regular business meeting held on... following actions: (1) Approved settlements involving two water resources projects; (2) approved or tabled...

  7. 77 FR 66214 - Actions Taken at September 20, 2012, Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-02

    ... SUSQUEHANNA RIVER BASIN COMMISSION Actions Taken at September 20, 2012, Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: As part of its regular business meeting held on September 20, 2012, in Harrisburg, Pennsylvania, the Commission took the following actions: approved or...

  8. 77 FR 19052 - Actions Taken at March 15, 2012, Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-29

    ... SUSQUEHANNA RIVER BASIN COMMISSION Actions Taken at March 15, 2012, Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: As part of its regular business meeting held on March 15, 2012, in Harrisburg, Pennsylvania, the Commission took the following actions: (1) Reconsidered...

  9. 78 FR 22938 - Actions Taken at March 21, 2013, Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-17

    ... SUSQUEHANNA RIVER BASIN COMMISSION Actions Taken at March 21, 2013, Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: As part of its regular business meeting held on March 21, 2013, in Harrisburg, Pennsylvania, the Commission took the following actions: (1) Approved...

  10. 78 FR 36148 - Petition for Reconsideration of Action in Rulemaking Proceeding

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-17

    ... for Reconsideration of Action in Rulemaking Proceeding AGENCY: Federal Communications Commission. ACTION: Petition for reconsideration. SUMMARY: In this document, a Petition for Reconsideration (Petition...

  11. 77 FR 58147 - Action Subject to Intergovernmental Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-19

    ... DEPARTMENT OF THE INTERIOR Office of Surface Mining Reclamation and Enforcement Action Subject to Intergovernmental Review AGENCY: Office of Surface Mining Reclamation and Enforcement, Interior. ACTION: Notice. SUMMARY: We, the Office of Surface Mining Reclamation and Enforcement, are notifying the public that we...

  12. 76 FR 78312 - Action Subject to Intergovernmental Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ... DEPARTMENT OF THE INTERIOR Office of Surface Mining Reclamation and Enforcement Action Subject to Intergovernmental Review AGENCY: Office of Surface Mining Reclamation and Enforcement, Interior. ACTION: Notice. SUMMARY: We, the Office of Surface Mining Reclamation and Enforcement, are notifying the public that we...

  13. Paving the Path to Success. Data for Action 2014. Summary

    ERIC Educational Resources Information Center

    Data Quality Campaign, 2014

    2014-01-01

    At the federal level, leaders can promote policies that reduce burdens on states, encourage collaboration across agencies, and help build the capacity of stakeholders to use data while ensuring the privacy of student information. The annual "Data for Action" survey measures states' progress toward achieving the 10 State Actions to Ensure…

  14. 75 FR 37380 - Trademark Trial and Appeal Board (TTAB) Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-29

    ... DEPARTMENT OF COMMERCE Patent and Trademark Office Trademark Trial and Appeal Board (TTAB) Actions ACTION: Proposed collection; comment request. SUMMARY: The United States Patent and Trademark Office... ``0651- 0040 Trademark Trial and Appeal Board (TTAB) Actions comment'' in the subject line of the message...

  15. 78 FR 73233 - Actions Taken at September 19, 2013, Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-05

    ... SUSQUEHANNA RIVER BASIN COMMISSION Actions Taken at September 19, 2013, Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: As part of its regular business meeting held on September 19, 2013, in Binghamton, New York, the Commission took the following actions: (1) Approved or...

  16. 76 FR 41855 - Actions Taken at June 23, 2011, Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-15

    ... SUSQUEHANNA RIVER BASIN COMMISSION Actions Taken at June 23, 2011, Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: As part of its regular business meeting held on June 23... actions: (1) Approved settlement involving one water resources project; (2) approved and tabled the...

  17. 78 FR 41972 - Actions Taken at June 20, 2013, Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-12

    ... SUSQUEHANNA RIVER BASIN COMMISSION Actions Taken at June 20, 2013, Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: As part of its regular business meeting held on June 20, 2013, in Harrisburg, Pennsylvania, the Commission took the following actions: (1) Approved or tabled...

  18. MSFC Skylab operations support summary

    NASA Technical Reports Server (NTRS)

    Martin, J. R.

    1974-01-01

    A summary of the actions and problems involved in preparing the Skylab-one vehicle is presented. The subjects discussed are: (1) flight operations support functions and organization, (2) launch operations and booster flight support functions and organization, (3) Skylab launch vehicle support teams, (4) Skylab orbital operations support performance analysis, (5) support manning and procedures, and (6) data support and facilities.

  19. 77 FR 40402 - Actions Taken at June 7, 2012 Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-09

    ... SUSQUEHANNA RIVER BASIN COMMISSION Actions Taken at June 7, 2012 Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: As part of its regular business meeting held on June 7, 2012, in Binghamton, New York, the Commission took the following actions: (1) Rescinded approval for one...

  20. 75 FR 36551 - State Highway-Rail Grade Crossing Action Plans

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-28

    ...-0032; Notice No. 5] RIN 2130-AC20 State Highway-Rail Grade Crossing Action Plans AGENCY: Federal Railroad Administration (FRA), Department of Transportation (DOT). ACTION: Final rule. SUMMARY: This final... three years, to develop State highway-rail grade crossing action plans. The final rule addresses the...

  1. Manned Space Programs Accident/Incident Summaries (1970 - 1971)

    NASA Technical Reports Server (NTRS)

    1972-01-01

    A compilation of 223 mishaps assembled from company and NASA records covering the Accident/Incident experience in 1970-1971 in the Manned Space Flight Programs is presented. It is the companion volume to NASA-CR-120998 which covered the years 1963-1969. The objectives of this summary is to make available to Government agencies and industrial firms the lessons learned from these mishaps. Each accident/incident summary has been reviewed by description, cause and recommended preventive action. The summaries have been categorized by the following ten systems: (1) Cryogenic; (2) Electrical; (3) Facility/GSE; (4) Fuel and Propellant; (5) Life Support; (6) Ordnance; (7) Pressure; (8) Propulsion; (9) Structural; and (10) Transport/Handling.

  2. Action Recognition Using Nonnegative Action Component Representation and Sparse Basis Selection.

    PubMed

    Wang, Haoran; Yuan, Chunfeng; Hu, Weiming; Ling, Haibin; Yang, Wankou; Sun, Changyin

    2014-02-01

    In this paper, we propose using high-level action units to represent human actions in videos and, based on such units, a novel sparse model is developed for human action recognition. There are three interconnected components in our approach. First, we propose a new context-aware spatial-temporal descriptor, named locally weighted word context, to improve the discriminability of the traditionally used local spatial-temporal descriptors. Second, from the statistics of the context-aware descriptors, we learn action units using the graph regularized nonnegative matrix factorization, which leads to a part-based representation and encodes the geometrical information. These units effectively bridge the semantic gap in action recognition. Third, we propose a sparse model based on a joint l2,1-norm to preserve the representative items and suppress noise in the action units. Intuitively, when learning the dictionary for action representation, the sparse model captures the fact that actions from the same class share similar units. The proposed approach is evaluated on several publicly available data sets. The experimental results and analysis clearly demonstrate the effectiveness of the proposed approach.

  3. Workshop on the preparation of climate change action plans. Workshop summary

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1999-05-24

    Over 130 participants from more than 27 countries shared experiences of developing and transition countries in preparation and development of their climate change national action plans. International experts guided countries in preparation of their climate change national action plans.

  4. Alternative dimensional reduction via the density matrix

    NASA Astrophysics Data System (ADS)

    de Carvalho, C. A.; Cornwall, J. M.; da Silva, A. J.

    2001-07-01

    We give graphical rules, based on earlier work for the functional Schrödinger equation, for constructing the density matrix for scalar and gauge fields in equilibrium at finite temperature T. More useful is a dimensionally reduced effective action (DREA) constructed from the density matrix by further functional integration over the arguments of the density matrix coupled to a source. The DREA is an effective action in one less dimension which may be computed order by order in perturbation theory or by dressed-loop expansions; it encodes all thermal matrix elements. We term the DREA procedure alternative dimensional reduction, to distinguish it from the conventional dimensionally reduced field theory (DRFT) which applies at infinite T. The DREA is useful because it gives a dimensionally reduced theory usable at any T including infinity, where it yields the DRFT, and because it does not and cannot have certain spurious infinities which sometimes occur in the density matrix itself or the conventional DRFT; these come from ln T factors at infinite temperature. The DREA can be constructed to all orders (in principle) and the only regularizations needed are those which control the ultraviolet behavior of the zero-T theory. An example of spurious divergences in the DRFT occurs in d=2+1φ4 theory dimensionally reduced to d=2. We study this theory and show that the rules for the DREA replace these ``wrong'' divergences in physical parameters by calculable powers of ln T; we also compute the phase transition temperature of this φ4 theory in one-loop order. Our density-matrix construction is equivalent to a construction of the Landau-Ginzburg ``coarse-grained free energy'' from a microscopic Hamiltonian.

  5. Community participation in biofilm matrix assembly and function.

    PubMed

    Mitchell, Kaitlin F; Zarnowski, Robert; Sanchez, Hiram; Edward, Jessica A; Reinicke, Emily L; Nett, Jeniel E; Mitchell, Aaron P; Andes, David R

    2015-03-31

    Biofilms of the fungus Candida albicans produce extracellular matrix that confers such properties as adherence and drug resistance. Our prior studies indicate that the matrix is complex, with major polysaccharide constituents being α-mannan, β-1,6 glucan, and β-1,3 glucan. Here we implement genetic, biochemical, and pharmacological approaches to unravel the contributions of these three constituents to matrix structure and function. Interference with synthesis or export of any one polysaccharide constituent altered matrix concentrations of each of the other polysaccharides. Each of these was also required for matrix function, as assessed by assays for sequestration of the antifungal drug fluconazole. These results indicate that matrix biogenesis entails coordinated delivery of the individual matrix polysaccharides. To understand whether coordination occurs at the cellular level or the community level, we asked whether matrix-defective mutant strains could be coaxed to produce functional matrix through biofilm coculture. We observed that mixed biofilms inoculated with mutants containing a disruption in each polysaccharide pathway had restored mature matrix structure, composition, and biofilm drug resistance. Our results argue that functional matrix biogenesis is coordinated extracellularly and thus reflects the cooperative actions of the biofilm community.

  6. Community participation in biofilm matrix assembly and function

    PubMed Central

    Mitchell, Kaitlin F.; Zarnowski, Robert; Sanchez, Hiram; Edward, Jessica A.; Reinicke, Emily L.; Nett, Jeniel E.; Mitchell, Aaron P.; Andes, David R.

    2015-01-01

    Biofilms of the fungus Candida albicans produce extracellular matrix that confers such properties as adherence and drug resistance. Our prior studies indicate that the matrix is complex, with major polysaccharide constituents being α-mannan, β-1,6 glucan, and β-1,3 glucan. Here we implement genetic, biochemical, and pharmacological approaches to unravel the contributions of these three constituents to matrix structure and function. Interference with synthesis or export of any one polysaccharide constituent altered matrix concentrations of each of the other polysaccharides. Each of these was also required for matrix function, as assessed by assays for sequestration of the antifungal drug fluconazole. These results indicate that matrix biogenesis entails coordinated delivery of the individual matrix polysaccharides. To understand whether coordination occurs at the cellular level or the community level, we asked whether matrix-defective mutant strains could be coaxed to produce functional matrix through biofilm coculture. We observed that mixed biofilms inoculated with mutants containing a disruption in each polysaccharide pathway had restored mature matrix structure, composition, and biofilm drug resistance. Our results argue that functional matrix biogenesis is coordinated extracellularly and thus reflects the cooperative actions of the biofilm community. PMID:25770218

  7. 77 FR 27280 - Actions Taken Pursuant to Executive Order 13382

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-09

    ... DEPARTMENT OF THE TREASURY Actions Taken Pursuant to Executive Order 13382 AGENCY: Office of Foreign Assets Control. ACTION: Notice. SUMMARY: The Treasury Department's Office of Foreign Assets Control (``OFAC'') is publishing on OFAC's list of Specially Designated Nationals and Blocked Persons...

  8. Cleft Palate Fistula Closure Utilizing Acellular Dermal Matrix

    PubMed Central

    Emodi, Omri; van Aalst, John A.; Shilo, Dekel; Naddaf, Raja; Aizenbud, Dror; Rachmiel, Adi

    2018-01-01

    Summary: Fistulas represent failure of cleft palate repair. Secondary and tertiary fistula repair is challenging, with high recurrence rates. In the present retrospective study, we review the efficacy of using acellular dermal matrix as an interposition layer for cleft palate fistula closure in 20 consecutive patients between 2013 and 2016. Complete fistula closure was obtained in 16 patients; 1 patient had asymptomatic recurrent fistula; 2 patients had partial closure with reduction of fistula size and minimal nasal regurgitation; 1 patient developed a recurrent fistula without changes in symptoms (success rate of 85%). We conclude that utilizing acellular dermal matrix for cleft palate fistula repair is safe and simple with a high success rate. PMID:29707449

  9. President's Report on AACC Strategic Action Areas and Initiatives.

    ERIC Educational Resources Information Center

    American Association of Community Colleges, Washington, DC.

    This is a summary of the American Association of Community College's (AACC) Strategic Action Areas and corresponding initiatives. Strategies for Action Area I (National and International Recognition and Advocacy for Community Colleges) focus primarily on the creation of task forces to address key legislative issues in higher education. Examples…

  10. 78 FR 17997 - Actions Taken Pursuant to Executive Order 13382

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-25

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Actions Taken Pursuant to Executive Order 13382 AGENCY: Office of Foreign Assets Control, Treasury Department. ACTION: Notice. SUMMARY: The Treasury Department's Office of Foreign Assets Control (``OFAC'') is publishing on OFAC's list of Specially...

  11. 78 FR 28702 - Actions Taken Pursuant to Executive Order 13382

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-15

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Actions Taken Pursuant to Executive Order 13382 AGENCY: Office of Foreign Assets Control, Treasury Department. ACTION: Notice. SUMMARY: The Treasury Department's Office of Foreign Assets Control (``OFAC'') is publishing on OFAC's list of Specially...

  12. 77 FR 37836 - Petition Requesting Commission Action Regarding Crib Bumpers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-25

    ... CONSUMER PRODUCT SAFETY COMMISSION 16 CFR Chapter II [Docket No. CPSC-2012-0034] Petition Requesting Commission Action Regarding Crib Bumpers AGENCY: U.S. Consumer Product Safety Commission. ACTION: Petition for rulemaking. SUMMARY: The U.S. Consumer Product Safety Commission (``Commission'') has received...

  13. 78 FR 17996 - Actions Taken Pursuant to Executive Order 13382

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-25

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Actions Taken Pursuant to Executive Order 13382 AGENCY: Office of Foreign Assets Control, Treasury Department. ACTION: Notice. SUMMARY: The Treasury Department's Office of Foreign Assets Control (``OFAC'') is publishing on OFAC's list of Specially...

  14. 77 FR 4399 - Actions Taken Pursuant to Executive Order 13382

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-27

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Actions Taken Pursuant to Executive Order 13382 AGENCY: Office of Foreign Assets Control, Treasury. ACTION: Notice. SUMMARY: The Treasury Department's Office of Foreign Assets Control (``OFAC'') is publishing on OFAC's list of Specially Designated...

  15. 78 FR 77203 - Actions Taken Pursuant to Executive Order 13382

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-20

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Actions Taken Pursuant to Executive Order 13382 AGENCY: Office of Foreign Assets Control, Treasury Department. ACTION: Notice. SUMMARY: The Treasury Department's Office of Foreign Assets Control (``OFAC'') is publishing on OFAC's list of Specially...

  16. 78 FR 34707 - Actions Taken Pursuant to Executive Order 13382

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Actions Taken Pursuant to Executive Order 13382 AGENCY: Office of Foreign Assets Control, Treasury Department. ACTION: Notice. SUMMARY: The Treasury Department's Office of Foreign Assets Control (``OFAC'') is publishing on OFAC's list of Specially...

  17. 78 FR 32303 - Actions Taken Pursuant to Executive Order 13382

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-29

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Actions Taken Pursuant to Executive Order 13382 AGENCY: Office of Foreign Assets Control, Treasury Department. ACTION: Notice. SUMMARY: The Treasury Department's Office of Foreign Assets Control (``OFAC'') is publishing on OFAC's list of Specially...

  18. 77 FR 43659 - Actions Taken Pursuant to Executive Order 13382

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-25

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Actions Taken Pursuant to Executive Order 13382 ACTION: Notice. SUMMARY: The Treasury Department's Office of Foreign Assets Control (``OFAC'') is publishing on OFAC's list of Specially Designated Nationals and Blocked Persons (``SDN List'') the...

  19. 77 FR 47164 - Actions Taken Pursuant to Executive Order 13382

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-07

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Actions Taken Pursuant to Executive Order 13382 AGENCY: Office of Foreign Assets Control, TD. ACTION: Notice. SUMMARY: The Treasury Department's Office of Foreign Assets Control (``OFAC'') is unblocking and removing three entities from OFAC...

  20. 78 FR 68419 - Trademark Trial and Appeal Board (TTAB) Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-14

    ... DEPARTMENT OF COMMERCE Patent and Trademark Office Trademark Trial and Appeal Board (TTAB) Actions ACTION: Proposed collection; comment request. SUMMARY: The United States Patent and Trademark Office (USPTO), as part of its continuing effort to reduce paperwork and respondent burden, invites the general...

  1. 78 FR 59766 - Actions Taken Pursuant to Executive Order 13382

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-27

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control [Case ID NPW-3360] Actions Taken Pursuant to Executive Order 13382 AGENCY: Office of Foreign Assets Control, Treasury Department. ACTION: Notice. SUMMARY: The Treasury Department's Office of Foreign Assets Control (``OFAC'') is publishing on...

  2. 78 FR 9995 - Actions Taken Pursuant to Executive Order 13382

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-12

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Actions Taken Pursuant to Executive Order 13382 AGENCY: Office of Foreign Assets Control, Treasury Department. ACTION: Notice. SUMMARY: The Treasury Department's Office of Foreign Assets Control (``OFAC'') is publishing on OFAC's list of Specially...

  3. 78 FR 25532 - Actions Taken Pursuant to Executive Order 13382

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-01

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Actions Taken Pursuant to Executive Order 13382 AGENCY: Office of Foreign Assets Control, Treasury Department. ACTION: Notice. SUMMARY: The Treasury Department's Office of Foreign Assets Control (``OFAC'') is publishing on OFAC's list of Specially...

  4. 78 FR 30396 - Actions Taken Pursuant to Executive Order 13382

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Actions Taken Pursuant to Executive Order 13382 AGENCY: Office of Foreign Assets Control, Treasury Department. ACTION: Notice. SUMMARY: The Treasury Department's Office of Foreign Assets Control (``OFAC'') is publishing on OFAC's list of Specially...

  5. 78 FR 41995 - Actions Taken Pursuant to Executive Order 13382

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-12

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Actions Taken Pursuant to Executive Order 13382 AGENCY: Office of Foreign Assets Control, Treasury Department. ACTION: Notice. SUMMARY: The Treasury Department's Office of Foreign Assets Control (``OFAC'') is publishing on OFAC's list of Specially...

  6. 78 FR 9996 - Actions Taken Pursuant to Executive Order 13382

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-12

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Actions Taken Pursuant to Executive Order 13382 AGENCY: Office of Foreign Assets Control, Treasury Department. ACTION: Notice. SUMMARY: The Treasury Department's Office of Foreign Assets Control (``OFAC'') is publishing on OFAC's list of Specially...

  7. 78 FR 9992 - Actions Taken Pursuant to Executive Order 13382

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-12

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Actions Taken Pursuant to Executive Order 13382 AGENCY: Office of Foreign Assets Control, Treasury Department ACTION: Notice SUMMARY: The Treasury Department's Office of Foreign Assets Control (OFAC), is publishing on OFAC's list of Specially...

  8. 78 FR 33471 - Actions Taken Pursuant to Executive Order 13382

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-04

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Actions Taken Pursuant to Executive Order 13382 AGENCY: Office of Foreign Assets Control, Treasury Department. ACTION: Notice. SUMMARY: The Treasury Department's Office of Foreign Assets Control (``OFAC'') is publishing on OFAC's list of Specially...

  9. 78 FR 8221 - Actions Taken Pursuant to Executive Order 13382

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-05

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Actions Taken Pursuant to Executive Order 13382 AGENCY: Office of Foreign Assets Control, Treasury Department. ACTION: Notice. SUMMARY: The Treasury Department's Office of Foreign Assets Control (``OFAC'') is publishing on OFAC's list of Specially...

  10. Matrix stiffness reverses the effect of actomyosin tension on cell proliferation

    PubMed Central

    Mih, Justin D.; Marinkovic, Aleksandar; Liu, Fei; Sharif, Asma S.; Tschumperlin, Daniel J.

    2012-01-01

    Summary The stiffness of the extracellular matrix exerts powerful effects on cell proliferation and differentiation, but the mechanisms transducing matrix stiffness into cellular fate decisions remain poorly understood. Two widely reported responses to matrix stiffening are increases in actomyosin contractility and cell proliferation. To delineate their relationship, we modulated cytoskeletal tension in cells grown across a physiological range of matrix stiffnesses. On both synthetic and naturally derived soft matrices, and across a panel of cell types, we observed a striking reversal of the effect of inhibiting actomyosin contractility, switching from the attenuation of proliferation on rigid substrates to the robust promotion of proliferation on soft matrices. Inhibiting contractility on soft matrices decoupled proliferation from cytoskeletal tension and focal adhesion organization, but not from cell spread area. Our results demonstrate that matrix stiffness and actomyosin contractility converge on cell spreading in an unexpected fashion to control a key aspect of cell fate. PMID:23097048

  11. ECOS E-MATRIX Methane and Volatile Organic Carbon (VOC) Emissions Best Practices Database

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Parisien, Lia

    2016-01-31

    This final scientific/technical report on the ECOS e-MATRIX Methane and Volatile Organic Carbon (VOC) Emissions Best Practices Database provides a disclaimer and acknowledgement, table of contents, executive summary, description of project activities, and briefing/technical presentation link.

  12. Communication: Wigner functions in action-angle variables, Bohr-Sommerfeld quantization, the Heisenberg correspondence principle, and a symmetrical quasi-classical approach to the full electronic density matrix

    DOE PAGES

    Miller, William H.; Cotton, Stephen J.

    2016-08-28

    It is pointed out that the classical phase space distribution in action-angle (a-a) variables obtained from a Wigner function depends on how the calculation is carried out: if one computes the standard Wigner function in Cartesian variables (p, x), and then replaces p and x by their expressions in terms of a-a variables, one obtains a different result than if the Wigner function is computed directly in terms of the a-a variables. Furthermore, the latter procedure gives a result more consistent with classical and semiclassical theory - e.g., by incorporating the Bohr-Sommerfeld quantization condition (quantum states defined by integer valuesmore » of the action variable) as well as the Heisenberg correspondence principle for matrix elements of an operator between such states - and has also been shown to be more accurate when applied to electronically non-adiabatic applications as implemented within the recently developed symmetrical quasi-classical (SQC) Meyer-Miller (MM) approach. Moreover, use of the Wigner function (obtained directly) in a-a variables shows how our standard SQC/MM approach can be used to obtain off-diagonal elements of the electronic density matrix by processing in a different way the same set of trajectories already used (in the SQC/MM methodology) to obtain the diagonal elements.« less

  13. Communication: Wigner functions in action-angle variables, Bohr-Sommerfeld quantization, the Heisenberg correspondence principle, and a symmetrical quasi-classical approach to the full electronic density matrix.

    PubMed

    Miller, William H; Cotton, Stephen J

    2016-08-28

    It is pointed out that the classical phase space distribution in action-angle (a-a) variables obtained from a Wigner function depends on how the calculation is carried out: if one computes the standard Wigner function in Cartesian variables (p, x), and then replaces p and x by their expressions in terms of a-a variables, one obtains a different result than if the Wigner function is computed directly in terms of the a-a variables. Furthermore, the latter procedure gives a result more consistent with classical and semiclassical theory-e.g., by incorporating the Bohr-Sommerfeld quantization condition (quantum states defined by integer values of the action variable) as well as the Heisenberg correspondence principle for matrix elements of an operator between such states-and has also been shown to be more accurate when applied to electronically non-adiabatic applications as implemented within the recently developed symmetrical quasi-classical (SQC) Meyer-Miller (MM) approach. Moreover, use of the Wigner function (obtained directly) in a-a variables shows how our standard SQC/MM approach can be used to obtain off-diagonal elements of the electronic density matrix by processing in a different way the same set of trajectories already used (in the SQC/MM methodology) to obtain the diagonal elements.

  14. 78 FR 68471 - Action Subject to Intergovernmental Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-14

    ... DEPARTMENT OF THE INTERIOR Office of Surface Mining Reclamation and Enforcement [S1D1SS08011000SX066A00067F134S180110; S2D2SS08011000SX066A00033F13XS501520] Action Subject to Intergovernmental Review AGENCY: Office of Surface Mining Reclamation and Enforcement, Interior. ACTION: Notice. SUMMARY: We, the Office of...

  15. [Quality assurance: concepts, actions and reflexions].

    PubMed

    Ruelas Barajas, E

    1994-01-01

    Importance that the topic of quality of medical care has acquired in recent years, a number of concepts have been utilized to mean many strategies to improve the quality of care. This situation has frequently created confusion between terms such as: quality assessment, quality assurance, total quality management, quality guarantee, etc. The purpose of this paper is to propose a conceptual framework that allows not only to clarify the concepts but also the actions towards the improvement of the quality of care. Therefore, a multidimensional matrix is also proposed in order to classify the multiple actions referred about in the literature and to organize them. The conclusions are: 1) The term "Quality guarantee", at least in spanish, is absolutely pertinent when referred to the quality of medical care; 2) This concept becomes a solid starting point to implement concret actions by integrating different concepts and avoiding confusions; 3) The multidimensional matrix allows to systematize multiple actions; 4) Since there was not a similar conceptual framework it is expected that this paper allows to close the gap between thinking and doing on behalf of every body.

  16. The Reflective Teacher Leader: An Action Research Model

    ERIC Educational Resources Information Center

    Furtado, Leena; Anderson, Dawnette

    2012-01-01

    This study presents four teacher reflections from action research projects ranging from kindergarten to adult school improvements. A teacher leadership matrix guided participants to connect teaching and learning theory to best practices by exploring uncharted territory within an iterative cycle of research and action. Teachers developed the…

  17. Nambu sigma model and effective membrane actions

    NASA Astrophysics Data System (ADS)

    Jurčo, Branislav; Schupp, Peter

    2012-07-01

    We propose an effective action for a p‧-brane with open p-branes ending on it. The action has dual descriptions similar to the commutative and non-commutative ones of the DBI action for D-branes and open strings. The Poisson structure governing the non-commutativity of the D-brane is replaced by a Nambu structure and the open-closed string relations are generalized to the case of p-branes utilizing a novel Nambu sigma model description of p-branes. In the case of an M5-brane our action interpolates between M5-actions already proposed in the literature and matrix-model like actions involving Nambu structures.

  18. 78 FR 8220 - Actions Taken Pursuant to Executive Order 13382

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-05

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Actions Taken Pursuant to Executive Order 13382 ACTION: Notice. SUMMARY: The Treasury Department's Office of Foreign Assets Control (``OFAC'') is announcing an update to the entry of an entity on OFAC's SDN List by adding an alias to the entity...

  19. 75 FR 60768 - Single-Ingredient Oral Colchicine Products; Enforcement Action Dates

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-01

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2010-N-0257] Single-Ingredient Oral Colchicine Products; Enforcement Action Dates AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA or agency) is announcing its...

  20. Informal and Formal Actions Summary of Guidance and Portrayal on EPA Websites

    EPA Pesticide Factsheets

    This discussion of formal and informal actions by program was provided to the Environmental Council of the States (ECOS) in 2010 by EPA Assistant Administrator Cynthia Giles. The states requested clarification on what EPA portrays as an informal action within ECHO.

  1. [Accessibility and resolution of mental health care: the matrix support experience].

    PubMed

    Quinderé, Paulo Henrique Dias; Jorge, Maria Salete Bessa; Nogueira, Maria Sônia Lima; Costa, Liduina Farias Almeida da; Vasconcelos, Mardenia Gomes Ferreira

    2013-07-01

    Psycho-social Care Centers (PCC) are also designed to coordinate actions in mental health care in Brazil, mainly at Primary Health Care (PHC) level. Matrix support is one of the pillars of the program, as it aims to ensure assistance of specialized back-up staff to the health teams. In this respect, this research seeks to understand how matrix actions in mental health contribute to the accessibility and resolution of mental health cases. This study involved qualitative research conducted in the cities of Fortaleza and Sobral in the State of Ceará, where 37 (thirty-seven) mental health workers, 14 (fourteen) primary health care users and 13 (thirteen) relatives who took part in matrix support actions were interviewed. As the results revealed, the PHC workers do not feel qualified to intervene in mental health cases. There is also excess haste in referring users to PCCs making access to mental health care more difficult. However, it was identified that discussions on mental health in primary care allow the appropriation of cases by PHC workers and promote rapprochement between the teams. In this way, they influence the resolution of mental health cases.

  2. Assessment of the Impact of Scheduled Postmarketing Safety Summary Analyses on Regulatory Actions

    PubMed Central

    Sekine, S; Pinnow, EE; Wu, E; Kurtzig, R; Hall, M; Dal Pan, GJ

    2016-01-01

    In addition to standard postmarketing drug safety monitoring, Section 915 of the Food and Drug Administration Amendments Act of 2007 (FDAAA) requires the US Food and Drug Administration (FDA) to conduct a summary analysis of adverse event reports to identify risks of a drug or biologic product 18 months after product approval, or after 10,000 patients have used the product, whichever is later. We assessed the extent to which these analyses identified new safety signals and resultant safety-related label changes. Among 458 newly approved products, 300 were the subjects of a scheduled analysis; a new safety signal that resulted in a safety-related label change was found for 11 of these products. Less than 2% of 713 safety-related label changes were based on the scheduled analyses. Our study suggests that the safety summary analyses provide only marginal value over other pharmacovigilance activities. PMID:26853718

  3. Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction

    PubMed Central

    Marchiq, Ibtissam; Albrengues, Jean; Granja, Sara; Gaggioli, Cédric; Pouysségur, Jacques; Simon, Marie-Pierre

    2015-01-01

    BASIGIN/CD147/EMMPRIN is a multifunctional transmembrane glycoprotein strongly expressed in tumours. BASIGIN controls tumour metabolism, particularly glycolysis by facilitating lactic acid export through the two monocarboxylate transporters MCT1 and hypoxia-inducible MCT4. However, before being recognized as a co-carrier of MCTs, BASIGIN was described as an inducer of extracellular matrix metalloproteases (MMPs). Early on, a model emerged in which, tumour cells use the extracellular domain of BASIGIN to recognize and stimulate neighbouring fibroblasts to produce MMPs. However, this model has remained hypothetical since a direct link between BASIGIN and MMPs production has not yet been clearly established. To validate the BASIGIN/MMP hypothesis, we developed BASIGIN knockouts in three human tumour cell lines derived from glioma, colon, and lung adenocarcinoma. By using co-culture experiments of either human or mouse fibroblasts and tumour cell lines we showed, contrary to what has been abundantly published, that the disruption of BASIGIN in tumour cells and in MEFs has no action on the production of MMPs. Our findings do not support the notion that the pro-tumoural action of BASIGIN is mediated via induction of MMPs. Therefore, we propose that to date, the strongest pro-tumoural action of BASIGIN is mediated through the control of fermentative glycolysis. PMID:26284589

  4. Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction.

    PubMed

    Marchiq, Ibtissam; Albrengues, Jean; Granja, Sara; Gaggioli, Cédric; Pouysségur, Jacques; Simon, Marie-Pierre

    2015-09-22

    BASIGIN/CD147/EMMPRIN is a multifunctional transmembrane glycoprotein strongly expressed in tumours. BASIGIN controls tumour metabolism, particularly glycolysis by facilitating lactic acid export through the two monocarboxylate transporters MCT1 and hypoxia-inducible MCT4. However, before being recognized as a co-carrier of MCTs, BASIGIN was described as an inducer of extracellular matrix metalloproteases (MMPs). Early on, a model emerged in which, tumour cells use the extracellular domain of BASIGIN to recognize and stimulate neighbouring fibroblasts to produce MMPs. However, this model has remained hypothetical since a direct link between BASIGIN and MMPs production has not yet been clearly established. To validate the BASIGIN/MMP hypothesis, we developed BASIGIN knockouts in three human tumour cell lines derived from glioma, colon, and lung adenocarcinoma. By using co-culture experiments of either human or mouse fibroblasts and tumour cell lines we showed, contrary to what has been abundantly published, that the disruption of BASIGIN in tumour cells and in MEFs has no action on the production of MMPs. Our findings do not support the notion that the pro-tumoural action of BASIGIN is mediated via induction of MMPs. Therefore, we propose that to date, the strongest pro-tumoural action of BASIGIN is mediated through the control of fermentative glycolysis.

  5. Dynamic nigrostriatal dopamine biases action selection

    PubMed Central

    Howard, Christopher D.; Li, Hao; Geddes, Claire E.; Jin, Xin

    2017-01-01

    Summary Dopamine is thought to play a critical role in reinforcement learning and goal-directed behavior, but its function in action selection remains largely unknown. Here, we demonstrate that nigrostriatal dopamine biases ongoing action selection. When mice were trained to dynamically switch the action selected at different time points, changes in firing rate of nigrostriatal dopamine neurons, as well as dopamine signaling in the dorsal striatum, were found to be associated with action selection. This dopamine profile is specific to behavioral choice, scalable with interval duration, and doesn’t reflect reward prediction error, timing, or value as single factors alone. Genetic deletion of NMDA receptors on dopamine or striatal neurons, or optogenetic manipulation of dopamine concentration, alters dopamine signaling and biases action selection. These results unveil a crucial role of nigrostriatal dopamine in integrating diverse information for regulating upcoming actions and have important implications for neurological disorders including Parkinson’s disease and substance dependence. PMID:28285820

  6. Multiple Phenotype Association Tests Using Summary Statistics in Genome-Wide Association Studies

    PubMed Central

    Liu, Zhonghua; Lin, Xihong

    2017-01-01

    Summary We study in this paper jointly testing the associations of a genetic variant with correlated multiple phenotypes using the summary statistics of individual phenotype analysis from Genome-Wide Association Studies (GWASs). We estimated the between-phenotype correlation matrix using the summary statistics of individual phenotype GWAS analyses, and developed genetic association tests for multiple phenotypes by accounting for between-phenotype correlation without the need to access individual-level data. Since genetic variants often affect multiple phenotypes differently across the genome and the between-phenotype correlation can be arbitrary, we proposed robust and powerful multiple phenotype testing procedures by jointly testing a common mean and a variance component in linear mixed models for summary statistics. We computed the p-values of the proposed tests analytically. This computational advantage makes our methods practically appealing in large-scale GWASs. We performed simulation studies to show that the proposed tests maintained correct type I error rates, and to compare their powers in various settings with the existing methods. We applied the proposed tests to a GWAS Global Lipids Genetics Consortium summary statistics data set and identified additional genetic variants that were missed by the original single-trait analysis. PMID:28653391

  7. Advanced Composites: Mechanical Properties and Hardware Programs for Selected Resin Matrix Materials. [considering space shuttle applications

    NASA Technical Reports Server (NTRS)

    Welhart, E. K.

    1976-01-01

    This design note presents typical mechanical properties tabulated from industrial and governmental agencies' test programs. All data are correlated to specific products and all of the best known products are presented. The data include six epoxies, eight polyimides and one polyquinoxaline matrix material. Bron and graphite are the fiber reinforcements. Included are forty-two summaries of advanced (resin matrix) composite programs in existence in the United States. It is concluded that the selection of appropriate matrices, the geometric manner in which the fibers are incorporated in the matrix and the durability of the bond between fiber and matrix establish the end properties of the composite material and the performance of the fabricated structure.

  8. 78 FR 71724 - Recordations, Water Carrier Tariffs, and Agricultural Contract Summaries

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-29

    ... DEPARTMENT OF TRANSPORTATION Surface Transportation Board Recordations, Water Carrier Tariffs, and Agricultural Contract Summaries AGENCY: Surface Transportation Board, DOT. ACTION: Notice of OMB Approval of..., Control Number 2140-0025 (2) Water Carrier Tariffs, Control Number 2140-26 (3) Agricultural Contract...

  9. Classical space-times from the S-matrix

    NASA Astrophysics Data System (ADS)

    Neill, Duff; Rothstein, Ira Z.

    2013-12-01

    We show that classical space-times can be derived directly from the S-matrix for a theory of massive particles coupled to a massless spin two particle. As an explicit example we derive the Schwarzchild space-time as a series in GN. At no point of the derivation is any use made of the Einstein-Hilbert action or the Einstein equations. The intermediate steps involve only on-shell S-matrix elements which are generated via BCFW recursion relations and unitarity sewing techniques. The notion of a space-time metric is only introduced at the end of the calculation where it is extracted by matching the potential determined by the S-matrix to the geodesic motion of a test particle. Other static space-times such as Kerr follow in a similar manner. Furthermore, given that the procedure is action independent and depends only upon the choice of the representation of the little group, solutions to Yang-Mills (YM) theory can be generated in the same fashion. Moreover, the squaring relation between the YM and gravity three point functions shows that the seeds that generate solutions in the two theories are algebraically related. From a technical standpoint our methodology can also be utilized to calculate quantities relevant for the binary inspiral problem more efficiently then the more traditional Feynman diagram approach.

  10. Teaching the extracellular matrix and introducing online databases within a multidisciplinary course with i-cell-MATRIX: A student-centered approach.

    PubMed

    Sousa, João Carlos; Costa, Manuel João; Palha, Joana Almeida

    2010-03-01

    The biochemistry and molecular biology of the extracellular matrix (ECM) is difficult to convey to students in a classroom setting in ways that capture their interest. The understanding of the matrix's roles in physiological and pathological conditions study will presumably be hampered by insufficient knowledge of its molecular structure. Internet-available resources can bridge the division between the molecular details and ECM's biological properties and associated processes. This article presents an approach to teach the ECM developed for first year medical undergraduates who, working in teams: (i) Explore a specific molecular component of the matrix, (ii) identify a disease in which the component is implicated, (iii) investigate how the component's structure/function contributes to ECM' supramolecular organization in physiological and in pathological conditions, and (iv) share their findings with colleagues. The approach-designated i-cell-MATRIX-is focused on the contribution of individual components to the overall organization and biological functions of the ECM. i-cell-MATRIX is student centered and uses 5 hours of class time. Summary of results and take home message: A "1-minute paper" has been used to gather student feedback on the impact of i-cell-MATRIX. Qualitative analysis of student feedback gathered in three consecutive years revealed that students appreciate the approach's reliance on self-directed learning, the interactivity embedded and the demand for deeper insights on the ECM. Learning how to use internet biomedical resources is another positive outcome. Ninety percent of students recommend the activity for subsequent years. i-cell-MATRIX is adaptable by other medical schools which may be looking for an approach that achieves higher student engagement with the ECM. Copyright © 2010 International Union of Biochemistry and Molecular Biology, Inc.

  11. Matrix metalloproteinases in kidney homeostasis and diseases

    PubMed Central

    Tan, Roderick J.

    2012-01-01

    Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that have been increasingly linked to both normal physiology and abnormal pathology in the kidney. Collectively able to degrade all components of the extracellular matrix, MMPs were originally thought to antagonize the development of fibrotic diseases solely through digestion of excessive matrix. However, increasing evidence has shown that MMPs play a wide variety of roles in regulating inflammation, epithelial-mesenchymal transition, cell proliferation, angiogenesis, and apoptosis. We now have robust evidence for MMP dysregulation in a multitude of renal diseases including acute kidney injury, diabetic nephropathy, glomerulonephritis, inherited kidney disease, and chronic allograft nephropathy. The goal of this review is to summarize current findings regarding the role of MMPs in kidney diseases as well as the mechanisms of action of this family of proteases. PMID:22492945

  12. Effects of boron derivatives on extracellular matrix formation.

    PubMed

    Benderdour, M; Van Bui, T; Hess, K; Dicko, A; Belleville, F; Dousset, B

    2000-10-01

    Boric acid solution (3%) dramatically improves wound healing through action on the extracellular matrix, a finding that has been obtained in vitro. Consequently, investigations are presently underway to produce boronated compounds having a therapeutical effectiveness similar to that of boric acid. On the basis of experimental results obtained with boric acid, we examined the effects of boron derivatives on extracellular matrix formation and degradation and analyzed their potential toxicity by using two biological models (chick embryo cartilage and human fibroblasts). The four boron derivatives tested in this study (triethanolamine borate; N-diethyl-phosphoramidate-propylboronique acid; 2,2 dimethylhexyl-1,3-propanediol-aminopropylboronate and 1,2 propanediol-aminopropylboronate) mimicked the effects of boric acid. They induced a decrease of intracellular concentrations in extracellular matrix macromolecules (proteoglycans, proteins)-associated with an increase of their release in culture medium and stimulated the activity of intra- and extracellular proteases. Similarly to boric acid, these actions occurred after exposure of the cells to concentrations of all boron derivatives without apparent toxic effects. The compounds were found to be more toxic than boric acid itself when concentrations were calculated according to their molecular weight. Nevertheless, these in vitro preliminary results demonstrate effects of boron derivatives that may be of therapeutic benefit in wound repair.

  13. Matrix Metalloproteinases in Non-Neoplastic Disorders

    PubMed Central

    Tokito, Akinori; Jougasaki, Michihisa

    2016-01-01

    The matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases belonging to the metzincin superfamily. There are at least 23 members of MMPs ever reported in human, and they and their substrates are widely expressed in many tissues. Recent growing evidence has established that MMP not only can degrade a variety of components of extracellular matrix, but also can cleave and activate various non-matrix proteins, including cytokines, chemokines and growth factors, contributing to both physiological and pathological processes. In normal conditions, MMP expression and activity are tightly regulated via interactions between their activators and inhibitors. Imbalance among these factors, however, results in dysregulated MMP activity, which causes tissue destruction and functional alteration or local inflammation, leading to the development of diverse diseases, such as cardiovascular disease, arthritis, neurodegenerative disease, as well as cancer. This article focuses on the accumulated evidence supporting a wide range of roles of MMPs in various non-neoplastic diseases and provides an outlook on the therapeutic potential of inhibiting MMP action. PMID:27455234

  14. The dual personalities of matrix metalloproteinases in inflammation.

    PubMed

    Le, Nghia T V; Xue, Meilang; Castelnoble, Laura A; Jackson, Christopher J

    2007-01-01

    Collagen, gelatin, elastin, fibronectin, proteoglycans and vitronectin are just a few proteins which form the "mesh" that holds a multicellular organism together. The matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade the extracellular matrix. Over several decades it has been clearly established that MMPs are the key molecules associated with matrix remodeling. The remodeling of this matrix is important for physiological and pathological processes such as pregnancy, wound repair, cancer and arthritis. The identification of new non-matrix MMP substrates involved in inflammation, highlights the diverse role of MMPs. These enzymes can enhance leukocyte invasion and regulate the inflammatory activity of serine proteases, cytokines and chemokines. Interestingly, the MMP family appears to have a "dual personality" in that several MMPs such as MMP-2 and -9 can favour either anti- or pro-inflammatory action, respectively. The extent of this dual functionality of MMPs is yet to be realized. Elucidating these processes may assist in the development of drugs for the treatment of inflammatory diseases such as arthritis, cancer and chronic wounds.

  15. Guns on Campus: The Architecture and Momentum of State Policy Action

    ERIC Educational Resources Information Center

    Morse, Andrew; Sisneros, Lauren; Perez, Zeke; Sponsler, Brian A.

    2016-01-01

    "Guns on Campus: The Architecture and Momentum of State Policy Action" offers a detailed summary of state legislative action and higher education system policy decisions that have occurred in two specific categories: (1) States that have permitted or are seeking to permit guns on campus; and (2) States that have prohibited or are seeking…

  16. Specialisation of extracellular matrix for function in tendons and ligaments

    PubMed Central

    Birch, Helen L.; Thorpe, Chavaunne T.; Rumian, Adam P.

    2013-01-01

    Summary Tendons and ligaments are similar structures in terms of their composition, organisation and mechanical properties. The distinction between them stems from their anatomical location; tendons form a link between muscle and bone while ligaments link bones to bones. A range of overlapping functions can be assigned to tendon and ligaments and each structure has specific mechanical properties which appear to be suited for particular in vivo function. The extracellular matrix in tendon and ligament varies in accordance with function, providing appropriate mechanical properties. The most useful framework in which to consider extracellular matrix differences therefore is that of function rather than anatomical location. In this review we discuss what is known about the relationship between functional requirements, structural properties from molecular to gross level, cellular gene expression and matrix turnover. The relevance of this information is considered by reviewing clinical aspects of tendon and ligament repair and reconstructive procedures. PMID:23885341

  17. Adapting Comparative Effectiveness Research Summaries for Delivery to Patients and Providers through a Patient Portal

    PubMed Central

    McDougald Scott, Amanda M.; Jackson, Gretchen Purcell; Ho, Yun-Xian; Yan, Zhou; Davison, Coda; Rosenbloom, S. Trent

    2013-01-01

    Despite increases in the scientific evidence for a variety of medical treatments, a gap remains in the adoption of best medical practices. This manuscript describes a process for adapting published summary guides from comparative effectiveness research to render them concise, targeted to audience, and easily actionable; and a strategy for disseminating such evidence to patients and their physicians through a web-based portal and linked electronic health record. This project adapted summary guides about oral medications for adults with type 2 diabetes to a fifth-grade literacy level and modified the resulting materials based on evaluations with the Suitability Assessment of Materials instrument. Focus groups and individual interviews with patients, diabetes providers, and health literacy experts were employed to evaluate and enhance the adapted summary guide. We present the lessons learned as general guidelines for the creation of concise, targeted, and actionable evidence and its delivery to both patients and providers through increasingly prevalent health information technologies. PMID:24551387

  18. 76 FR 46356 - Notice of Final Federal Agency Actions on Proposed Highway in Idaho

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-02

    ... Limitation on Claims for Judicial Review of Actions by FHWA. SUMMARY: This notice announces actions taken by....C. 139(I)(1). A claim seeking judicial review of the Federal agency actions on the highway project will be barred unless the claim is filed on or prior to January 29, 2012. If the Federal law that...

  19. 75 FR 28851 - Notice of Final Federal Agency Actions on Proposed Highway in Washington

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-24

    ... of limitation on claims for judicial review of actions by FHWA. SUMMARY: This notice announces... advising the public of final agency actions subject to 23 U.S.C. 139(l)(1). A claim seeking judicial review of the Federal agency actions on the highway project will be barred unless the claim is filed within...

  20. 78 FR 58380 - Notice of Final Federal Agency Actions on Proposed Highway in Illinois

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-23

    ... limitation on claims for judicial review of actions by FHWA and other Federal agencies. SUMMARY: This notice announces actions taken by the FHWA and other Federal agencies that are final within the meaning of 23 U.S.C.... DATES: By this notice, the FHWA is advising the public of final agency actions subject to 23 U.S.C. 139...

  1. 75 FR 41277 - Notice of Final Federal Agency Actions on Proposed Highway in California

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-15

    ... of Limitation on Claims for Judicial Review of Actions by FHWA and Other Federal Agencies. SUMMARY... actions subject to 23 U.S.C. 139(l)(1). A claim seeking judicial review of the Federal agency actions on the highway project will be barred unless the claim is filed on or before January 11, 2011. If the...

  2. Government and Higher Education: A Summary of 21 Institutional Self-Studies.

    ERIC Educational Resources Information Center

    Spero, Irene K.

    A summary of 21 institutional self-studies concerning government and higher education considers the following areas: equal employment, affirmative action, and nondiscrimination; student affairs (student assistance and the Buckley Amendment); research; and safety and health. Brief excerpts from the institutional reports are presented on these issue…

  3. 75 FR 22625 - Notice of Realty Action; Direct Sale of Public Land in Jerome County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-29

    ... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLIDT03000-L14300000.EU0000; IDI-35577] Notice of Realty Action; Direct Sale of Public Land in Jerome County, ID AGENCY: Bureau of Land Management, Interior. ACTION: Notice of Realty Action. SUMMARY: To resolve an unintentional trespass, a...

  4. 78 FR 25301 - Notice of Realty Action: Recreation and Public Purposes Act Classification and Conveyance of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    ... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLCON020000 L14300000.FR0000; COC-73927] Notice of Realty Action: Recreation and Public Purposes Act Classification and Conveyance of Public Land; Jackson County, CO AGENCY: Bureau of Land Management, Interior. ACTION: Notice of Realty Action. SUMMARY...

  5. ANALYSIS OF A CLASSIFICATION ERROR MATRIX USING CATEGORICAL DATA TECHNIQUES.

    USGS Publications Warehouse

    Rosenfield, George H.; Fitzpatrick-Lins, Katherine

    1984-01-01

    Summary form only given. A classification error matrix typically contains tabulation results of an accuracy evaluation of a thematic classification, such as that of a land use and land cover map. The diagonal elements of the matrix represent the counts corrected, and the usual designation of classification accuracy has been the total percent correct. The nondiagonal elements of the matrix have usually been neglected. The classification error matrix is known in statistical terms as a contingency table of categorical data. As an example, an application of these methodologies to a problem of remotely sensed data concerning two photointerpreters and four categories of classification indicated that there is no significant difference in the interpretation between the two photointerpreters, and that there are significant differences among the interpreted category classifications. However, two categories, oak and cottonwood, are not separable in classification in this experiment at the 0. 51 percent probability. A coefficient of agreement is determined for the interpreted map as a whole, and individually for each of the interpreted categories. A conditional coefficient of agreement for the individual categories is compared to other methods for expressing category accuracy which have already been presented in the remote sensing literature.

  6. Anabolic action of parathyroid hormone (PTH) does not compromise bone matrix mineral composition or maturation.

    PubMed

    Vrahnas, Christina; Pearson, Thomas A; Brunt, Athena R; Forwood, Mark R; Bambery, Keith R; Tobin, Mark J; Martin, T John; Sims, Natalie A

    2016-12-01

    Intermittent administration of parathyroid hormone (PTH) is used to stimulate bone formation in patients with osteoporosis. A reduction in the degree of matrix mineralisation has been reported during treatment, which may reflect either production of undermineralised matrix or a greater proportion of new matrix within the bone samples assessed. To explore these alternatives, high resolution synchrotron-based Fourier Transform Infrared Microspectroscopy (sFTIRM) coupled with calcein labelling was used in a region of non-remodelling cortical bone to determine bone composition during anabolic PTH treatment compared with region-matched samples from controls. 8week old male C57BL/6 mice were treated with vehicle or 50μg/kg PTH, 5 times/week for 4weeks (n=7-9/group). Histomorphometry confirmed greater trabecular and periosteal bone formation and 3-point bending tests confirmed greater femoral strength in PTH-treated mice. Dual calcein labels were used to match bone regions by time-since-mineralisation (bone age) and composition was measured by sFTIRM in six 15μm 2 regions at increasing depth perpendicular to the most immature bone on the medial periosteal edge; this allowed in situ measurement of progressive changes in bone matrix during its maturation. The sFTIRM method was validated in vehicle-treated bones where the expected progressive increases in mineral:matrix ratio and collagen crosslink type ratio were detected with increasing bone maturity. We also observed a gradual increase in carbonate content that strongly correlated with an increase in longitudinal stretch of the collagen triple helix (amide I:amide II ratio). PTH treatment did not alter the progressive changes in any of these parameters from the periosteal edge through to the more mature bone. These data provide new information about how the bone matrix matures in situ and confirm that bone deposited during PTH treatment undergoes normal collagen maturation and normal mineral accrual. Copyright © 2016

  7. 78 FR 68422 - Patent Trial and Appeal Board (PTAB) Actions (Formerly Board of Patent Appeals and Interferences...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-14

    ... DEPARTMENT OF COMMERCE Patent and Trademark Office Patent Trial and Appeal Board (PTAB) Actions (Formerly Board of Patent Appeals and Interferences (BPAI) Actions) ACTION: Proposed collection; comment request. SUMMARY: The United States Patent and Trademark Office (USPTO), as part of its continuing efforts...

  8. Designing a good life: a matrix for the technological mediation of morality.

    PubMed

    Swierstra, Tsjalling; Waelbers, Katinka

    2012-03-01

    Technologies fulfill a social role in the sense that they influence the moral actions of people, often in unintended and unforeseen ways. Scientists and engineers are already accepting much responsibility for the technological, economical and environmental aspects of their work. This article asks them to take an extra step, and now also consider the social role of their products. The aim is to enable engineers to take a prospective responsibility for the future social roles of their technologies by providing them with a matrix that helps to explore in advance how emerging technologies might plausibly affect the reasons behind people's (moral) actions. On the horizontal axis of the matrix, we distinguished the three basic types of reasons that play a role in practical judgment: what is the case, what can be done and what should be done. On the vertical axis we distinguished the morally relevant classes of issues: stakeholders, consequences and the good life. To illustrate how this matrix may work in practice, the final section applies the matrix to the case of the Google PowerMeter. © The Author(s) 2010. This article is published with open access at Springerlink.com

  9. Actions of the A.M.A. House of Delegates

    PubMed Central

    Blasingame, F. J. L.

    1960-01-01

    This summary from the Executive Vice-President's office of the American Medical Association covers only a few of the many important subjects dealt with by the House and is not intended as a detailed report on all actions taken. PMID:18732312

  10. 19 CFR 206.7 - Confidential business information; furnishing of nonconfidential summaries thereof.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Confidential business information; furnishing of nonconfidential summaries thereof. 206.7 Section 206.7 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO GLOBAL AND BILATERAL SAFEGUARD ACTIONS, MARKET...

  11. 19 CFR 206.7 - Confidential business information; furnishing of nonconfidential summaries thereof.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 3 2013-04-01 2013-04-01 false Confidential business information; furnishing of nonconfidential summaries thereof. 206.7 Section 206.7 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO GLOBAL AND BILATERAL SAFEGUARD ACTIONS, MARKET...

  12. 19 CFR 206.7 - Confidential business information; furnishing of nonconfidential summaries thereof.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 3 2014-04-01 2014-04-01 false Confidential business information; furnishing of nonconfidential summaries thereof. 206.7 Section 206.7 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO GLOBAL AND BILATERAL SAFEGUARD ACTIONS, MARKET...

  13. 76 FR 44948 - Status Report of Water Service, Repayment, and Other Water-Related Contract Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    ... DEPARTMENT OF THE INTERIOR Bureau of Reclamation Status Report of Water Service, Repayment, and Other Water- Related Contract Actions AGENCY: Bureau of Reclamation, Interior. ACTION: Notice. SUMMARY... SUPPLEMENTARY INFORMATION section. FOR FURTHER INFORMATION CONTACT: Michelle Kelly, Water and Environmental...

  14. 76 FR 73674 - Status Report of Water Service, Repayment, and Other Water-Related Contract Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-29

    ... DEPARTMENT OF THE INTERIOR Bureau of Reclamation Status Report of Water Service, Repayment, and Other Water- Related Contract Actions AGENCY: Bureau of Reclamation, Interior. ACTION: Notice. SUMMARY... INFORMATION CONTACT: Michelle Kelly, Water and Environmental Resources Division, Bureau of Reclamation, P.O...

  15. Action Research Projects in Pre-Service Teacher Education

    ERIC Educational Resources Information Center

    Clayton, Courtney; Meadows, George

    2013-01-01

    Classroom-centered Action Research Projects are an integral component of the M.S. in Elementary Education Program at the University's (pseudonym) College of Education. This article provides a summary and discussion of the projects completed by students in the Science, Technology, Literacy and English Language Learner Specializations of the…

  16. Biological actions of curcumin on articular chondrocytes.

    PubMed

    Henrotin, Y; Clutterbuck, A L; Allaway, D; Lodwig, E M; Harris, P; Mathy-Hartert, M; Shakibaei, M; Mobasheri, A

    2010-02-01

    Curcumin (diferuloylmethane) is the principal biochemical component of the spice turmeric and has been shown to possess potent anti-catabolic, anti-inflammatory and antioxidant, properties. This article aims to provide a summary of the actions of curcumin on articular chondrocytes from the available literature with the use of a text-mining tool. We highlight both the potential benefits and drawbacks of using this chemopreventive agent for treating osteoarthritis (OA). We also explore the recent literature on the molecular mechanisms of curcumin mediated alterations in gene expression mediated via activator protein 1 (AP-1)/nuclear factor-kappa B (NF-kappaB) signalling in chondrocytes, osteoblasts and synovial fibroblasts. A computer-aided search of the PubMed/Medline database aided by a text-mining tool to interrogate the ResNet Mammalian database 6.0. Recent work has shown that curcumin protects human chondrocytes from the catabolic actions of interleukin-1 beta (IL-1beta) including matrix metalloproteinase (MMP)-3 up-regulation, inhibition of collagen type II and down-regulation of beta1-integrin expression. Curcumin blocks IL-1beta-induced proteoglycan degradation, AP-1/NF-kappaB signalling, chondrocyte apoptosis and activation of caspase-3. The available data from published in vitro and in vivo studies suggest that curcumin may be a beneficial complementary treatment for OA in humans and companion animals. Nevertheless, before initiating extensive clinical trials, more basic research is required to improve its solubility, absorption and bioavailability and gain additional information about its safety and efficacy in different species. Once these obstacles have been overcome, curcumin and structurally related biochemicals may become safer and more suitable nutraceutical alternatives to the non-steroidal anti-inflammatory drugs that are currently used for the treatment of OA. Copyright 2009 Osteoarthritis Research Society International. All rights reserved.

  17. 78 FR 58381 - Notice of Final Federal Agency Actions on State Highway 288 in Texas

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-23

    ... final agency actions subject to 23 U.S.C. 139(l)(1). A claim seeking judicial review of the Federal... limitation on claims for judicial review of actions by FHWA and other Federal agencies. SUMMARY: This notice announces actions taken by the FHWA and other Federal agencies that are final within the meaning of 23 U.S.C...

  18. 24 CFR 248.213 - Plan of action.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... of the effect of the proposed changes on existing tenants. (6) In the case of a plan of action involving incentives, an appraisal using the residential income approach; (7) In the case of a plan of... summary, the local HUD field office, and the on-site office for the project, or if one is not available...

  19. 24 CFR 248.213 - Plan of action.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... of the effect of the proposed changes on existing tenants. (6) In the case of a plan of action involving incentives, an appraisal using the residential income approach; (7) In the case of a plan of... summary, the local HUD field office, and the on-site office for the project, or if one is not available...

  20. 24 CFR 248.213 - Plan of action.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... of the effect of the proposed changes on existing tenants. (6) In the case of a plan of action involving incentives, an appraisal using the residential income approach; (7) In the case of a plan of... summary, the local HUD field office, and the on-site office for the project, or if one is not available...

  1. 24 CFR 248.213 - Plan of action.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... of the effect of the proposed changes on existing tenants. (6) In the case of a plan of action involving incentives, an appraisal using the residential income approach; (7) In the case of a plan of... summary, the local HUD field office, and the on-site office for the project, or if one is not available...

  2. 24 CFR 248.213 - Plan of action.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... of the effect of the proposed changes on existing tenants. (6) In the case of a plan of action involving incentives, an appraisal using the residential income approach; (7) In the case of a plan of... summary, the local HUD field office, and the on-site office for the project, or if one is not available...

  3. 76 FR 60527 - Status Report of Water Service, Repayment, and Other Water-Related Contract Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-29

    ... DEPARTMENT OF THE INTERIOR Bureau of Reclamation Status Report of Water Service, Repayment, and Other Water- Related Contract Actions AGENCY: Bureau of Reclamation, Interior. ACTION: Notice. SUMMARY... CONTACT: Michelle Kelly, Water and Environmental Resources Division, Bureau of Reclamation, P.O. Box 25007...

  4. 75 FR 82066 - Status Report of Water Service, Repayment, and Other Water-Related Contract Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ... DEPARTMENT OF THE INTERIOR Bureau of Reclamation Status Report of Water Service, Repayment, and Other Water- Related Contract Actions AGENCY: Bureau of Reclamation, Interior. ACTION: Notice. SUMMARY... CONTACT: Michelle Kelly, Water and Environmental Services Division, Bureau of Reclamation, P.O. Box 25007...

  5. Optimal development of matrix elasticity

    PubMed Central

    Majkut, Stephanie; Idema, Timon; Swift, Joe; Krieger, Christine; Liu, Andrea; Discher, Dennis E.

    2014-01-01

    Summary In development and differentiation, morphological changes often accompany mechanical changes [1], but it is unclear if or when cells in embryos sense tissue elasticity. The earliest embryo is uniformly pliable while adult tissues vary widely in mechanics from soft brain and stiff heart to rigid bone [2], but the sensitivity of cells to microenvironment elasticity is debated [3]. Regenerative cardiology provides strong motivation because rigid post-infarct regions limit pumping by the adult heart [4]. Here we focus on embryonic heart and isolated cardiomyocytes, which both beat spontaneously. Tissue elasticity, Et, increases daily for heart to 1-2 kiloPascal by embryonic day-4 (E4), and although this is ∼10-fold softer than adult heart, the beating contractions of E4-cardiomyocytes prove optimal at ∼Et,E4 both in vivo and in vitro. Proteomics reveals daily increases in a small subset of proteins, namely collagen plus cardiac-specific excitation-contraction proteins. Rapid softening of the heart's matrix with collagenase or stiffening it with enzymatic crosslinking suppresses beating. Sparsely cultured E4-cardiomyocytes on collagen-coated gels likewise show maximal contraction on matrices with native E4 stiffness, highlighting cell-intrinsic mechanosensitivity. While an optimal elasticity for striation proves consistent with the mathematics of force-driven sarcomere registration, contraction wave-speed is linear in Et as theorized for Excitation-Contraction Coupled to Matrix Elasticity. Mechanosensitive stem cell cardiogenesis helps generalize tissue results, which demonstrate how myosin-II organization and contractile function is optimally matched to the load presented by matrix elasticity. PMID:24268417

  6. 77 FR 48168 - Correction for Notice of Realty Action; Recreation and Public Purposes Act Classification...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-13

    ... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLCAD09000.L14300000.ES0000; CACA- 051457] Correction for Notice of Realty Action; Recreation and Public Purposes Act Classification; California AGENCY: Bureau of Land Management, Interior. ACTION: Correction SUMMARY: This notice corrects a Notice of Realty...

  7. A summary of recent developments in transportation hazard classification activities for ammonium perchlorate

    NASA Technical Reports Server (NTRS)

    Koller, A. M., Jr.; Hannum, J. A. E.

    1983-01-01

    The transportation hazard classification of Ammonium Perchlorate is discussed. A test program was completed and data were forwarded to retain a Class 5.1 designation (oxidizer) for AP which is shipped internationally. As a follow-on to the initial team effort to conduct AP tests existing data were examined and a matrix which catalogs test parameters and findings was compiled. A collection of test protocols is developed to standardize test methods for energetic materials of all types. The actions to date are summarized; the participating organizations and their roles as presently understood; specific findings on AP (matrix); and issues, lessons learned, and potential actions of particular interest to the propulsion community which may evolve as a result of future U.N. propellant transportation classification activities.

  8. Comparison summary: Various countries' standards for classroom acoustics

    NASA Astrophysics Data System (ADS)

    Evans, Jack B.

    2005-09-01

    A comparative summary presentation of many countries' national acoustical standards for classroom acoustics will be presented. Facility renovation or new construction is subject to standards or regulations that control reverberation decay time, sound isolation between interior spaces, intrusive noise from the exterior environment, background noise from building systems and/or user installed classroom equipment. Child learner physical conditions are reviewed, based on many researchers' published results in North America and Europe, in regard to the special building acoustical requirements needed to achieve good classroom environments. In response to the authors' solicitations, colleagues from many nations provided facts, opinions, and reference for their own countries' standards, which are presented in categorical matrix format, including ANSI S12.60-2002, the relatively new American classroom acoustics standard. Summary results from I-INCE TC4 working group study on international standards are also incorporated. [This presentation is derived from the international classroom standards portion (only) of a paper originally written for the 11th International Meeting on Low Frequency Noise and Vibration and its Control, Maastricht, The Netherlands in 2004 with recent updates.

  9. 75 FR 28278 - Notice of amendment to Notice of Realty Action: Competitive Online Auction of Public Lands in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-20

    .... ACTION: Notice of amendment. SUMMARY: This notice amends a Notice of Realty Action (NORA) published in... GSA Web site, https://www.auctionrp.com/ . The NORA published on September 11, 2009, is amended to...

  10. 76 FR 2949 - Notice of Final Federal Agency Actions on Proposed Project in Washington

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-18

    ... of limitation on claims for judicial review of actions by FHWA. SUMMARY: This notice announces... a proposed project, the SR 520 Pontoon Construction Project in the State of Washington. Those... agency actions subject to 23 U.S.C. 139(l)(1). A claim seeking judicial review of the Federal agency...

  11. Helium in inert matrix dispersion fuels

    NASA Astrophysics Data System (ADS)

    van Veen, A.; Konings, R. J. M.; Fedorov, A. V.

    2003-07-01

    The behaviour of helium, an important decay product in the transmutation chains of actinides, in dispersion-type inert matrix fuels is discussed. A phenomenological description of its accumulation and release in CERCER and CERMET fuel is given. A summary of recent He-implantation studies with inert matrix metal oxides (ZrO 2, MgAl 2O 4, MgO and Al 2O 3) is presented. A general picture is that for high helium concentrations helium and vacancy defects form helium clusters which convert into over-pressurized bubbles. At elevated temperature helium is released from the bubbles. On some occasions thermal stable nano-cavities or nano-pores remain. On the basis of these results the consequences for helium induced swelling and helium storage in oxide matrices kept at 800-1000 °C will be discussed. In addition, results of He-implantation studies for metal matrices (W, Mo, Nb and V alloys) will be presented. Introduction of helium in metals at elevated temperatures leads to clustering of helium to bubbles. When operational temperatures are higher than 0.5 melting temperature, swelling and helium embrittlement might occur.

  12. 77 FR 7980 - Department Regulatory Agenda; Semiannual Summary

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-13

    ...The Regulatory Agenda is a semiannual summary of all current and projected rulemakings, reviews of existing regulations, and completed actions of the Department. The Agenda provides the public with information about the Department of Transportation's regulatory activity. It is expected that this information will enable the public to be more aware of and allow it to more effectively participate in the Department's regulatory activity. The public is also invited to submit comments on any aspect of this Agenda.

  13. 75 FR 79811 - Department Regulatory Agenda; Semiannual Summary

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ...The regulatory agenda is a semiannual summary of all current and projected rulemakings, reviews of existing regulations, and completed actions of the Department. The agenda provides the public with information about the Department of Transportation's regulatory activity. It is expected that this information will enable the public to be more aware of and allow it to more effectively participate in the Department's regulatory activity. The public is also invited to submit comments on any aspect of this agenda.

  14. 75 FR 21839 - Department Regulatory Agenda; Semiannual Summary

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ...The regulatory agenda is a semiannual summary of all current and projected rulemakings, reviews of existing regulations, and completed actions of the Department. The agenda provides the public with information about the Department of Transportation's regulatory activity. It is expected that this information will enable the public to be more aware of and allow it to more effectively participate in the Department's regulatory activity. The public is also invited to submit comments on any aspect of this agenda.

  15. Ares Knowledge Capture: Summary and Key Themes Presentation

    NASA Technical Reports Server (NTRS)

    Coates, Ralph H.

    2011-01-01

    This report has been developed by the National Aeronautics and Space Administration (NASA) Human Exploration and Operations Mission Directorate (HEOMD) Risk Management team in close coordination with the MSFC Chief Engineers Office. This document provides a point-in-time, cumulative, summary of actionable key lessons learned derived from the design project. Lessons learned invariably address challenges and risks and the way in which these areas have been addressed. Accordingly the risk management thread is woven throughout the document.

  16. 75 FR 77659 - Notice of Realty Action; Recreation and Public Purposes Act Classification for Conveyance of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-13

    ...-88037] Notice of Realty Action; Recreation and Public Purposes Act Classification for Conveyance of... action. SUMMARY: The Bureau of Land Management (BLM) has examined and found suitable for classification...: Interested parties may submit written comments regarding this proposed classification for conveyance of...

  17. Multiple phenotype association tests using summary statistics in genome-wide association studies.

    PubMed

    Liu, Zhonghua; Lin, Xihong

    2018-03-01

    We study in this article jointly testing the associations of a genetic variant with correlated multiple phenotypes using the summary statistics of individual phenotype analysis from Genome-Wide Association Studies (GWASs). We estimated the between-phenotype correlation matrix using the summary statistics of individual phenotype GWAS analyses, and developed genetic association tests for multiple phenotypes by accounting for between-phenotype correlation without the need to access individual-level data. Since genetic variants often affect multiple phenotypes differently across the genome and the between-phenotype correlation can be arbitrary, we proposed robust and powerful multiple phenotype testing procedures by jointly testing a common mean and a variance component in linear mixed models for summary statistics. We computed the p-values of the proposed tests analytically. This computational advantage makes our methods practically appealing in large-scale GWASs. We performed simulation studies to show that the proposed tests maintained correct type I error rates, and to compare their powers in various settings with the existing methods. We applied the proposed tests to a GWAS Global Lipids Genetics Consortium summary statistics data set and identified additional genetic variants that were missed by the original single-trait analysis. © 2017, The International Biometric Society.

  18. 75 FR 8786 - Notice of Final Federal Agency Actions on Proposed Highway in Indiana

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-25

    ... (USFWS), DOI. SUMMARY: This notice announces actions taken by the FHWA and the USFWS that are final... (USFWS), DOI, was published in the Federal Register on April 17, 2007. A claim seeking judicial review of... Claims for Judicial Review of these actions and decisions by the USFWS, DOI, was published in the Federal...

  19. 76 FR 60583 - Notice of Final Federal Agency Actions on Proposed Highway in Indiana

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-29

    ... (USFWS), DOI. SUMMARY: This notice announces actions taken by the FHWA and the USFWS that are final... (USFWS), DOI, was published in the Federal Register on April 17, 2007. A claim seeking judicial review of... Claims for Judicial Review of these actions and decisions by the USFWS, DOI, was published in the Federal...

  20. California state information handbook: formerly utilized sites remedial action program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the state of California. It contains: a description of themore » state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; the full text of relevant statutes and regulations.« less

  1. Oregon state information handbook formerly utilized sites remedial action program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administater, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Oregon. It contains: a description of themore » state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.« less

  2. Iowa state information handbook: formerly utilized sites remedial action program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    This volume is one of a series produced under contract with the DOE, By Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the state of Iowa. It contains: a description of themore » state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; the full test of relevant statutes and regulations.« less

  3. Oregon state information handbook: formerly utilized sites remedial action program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Oregon. It contains a description of themore » state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.« less

  4. Pennsylvania state information handbook: formerly utilized sites remedial action program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and State levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Pennsylvania. It contains a description of themore » state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.« less

  5. Florida state information handbook: formerly utilized sites remedial action program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    This volume is one of a series produced under contract with DOE, Office of Nuclear Waste Management, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the federal and state levels, the pertinent programs they administer, each affected state legislature, and current federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Florida. It contains a description ofmore » the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.« less

  6. Modulation of the degree and pattern of methyl-esterification of pectic homogalacturonan in plant cell walls. Implications for pectin methyl esterase action, matrix properties, and cell adhesion.

    PubMed

    Willats, W G; Orfila, C; Limberg, G; Buchholt, H C; van Alebeek, G J; Voragen, A G; Marcus, S E; Christensen, T M; Mikkelsen, J D; Murray, B S; Knox, J P

    2001-06-01

    Homogalacturonan (HG) is a multifunctional pectic polysaccharide of the primary cell wall matrix of all land plants. HG is thought to be deposited in cell walls in a highly methyl-esterified form but can be subsequently de-esterified by wall-based pectin methyl esterases (PMEs) that have the capacity to remove methyl ester groups from HG. Plant PMEs typically occur in multigene families/isoforms, but the precise details of the functions of PMEs are far from clear. Most are thought to act in a processive or blockwise fashion resulting in domains of contiguous de-esterified galacturonic acid residues. Such de-esterified blocks of HG can be cross-linked by calcium resulting in gel formation and can contribute to intercellular adhesion. We demonstrate that, in addition to blockwise de-esterification, HG with a non-blockwise distribution of methyl esters is also an abundant feature of HG in primary plant cell walls. A partially methyl-esterified epitope of HG that is generated in greatest abundance by non-blockwise de-esterification is spatially regulated within the cell wall matrix and occurs at points of cell separation at intercellular spaces in parenchymatous tissues of pea and other angiosperms. Analysis of the properties of calcium-mediated gels formed from pectins containing HG domains with differing degrees and patterns of methyl-esterification indicated that HG with a non-blockwise pattern of methyl ester group distribution is likely to contribute distinct mechanical and porosity properties to the cell wall matrix. These findings have important implications for our understanding of both the action of pectin methyl esterases on matrix properties and mechanisms of intercellular adhesion and its loss in plants.

  7. 76 FR 60524 - Notice of Realty Action: Recreation and Public Purposes Act Classification and Conveyance of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-29

    ...-83291] Notice of Realty Action: Recreation and Public Purposes Act Classification and Conveyance of... Action. SUMMARY: The Bureau of Land Management (BLM) has examined and found suitable for classification... this classification and conveyance of public land until November 14, 2011. ADDRESSES: Comments may be...

  8. 75 FR 26789 - Notice of Realty Action; Recreation and Public Purposes Act Classification for Conveyance of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ...-87630] Notice of Realty Action; Recreation and Public Purposes Act Classification for Conveyance of... Action. SUMMARY: The Bureau of Land Management (BLM) has examined and found suitable for classification... this classification for conveyance of public land until June 28, 2010. ADDRESSES: Comments may be...

  9. Youth Social Action Trials: Youth United. Evaluation Report and Executive Summary

    ERIC Educational Resources Information Center

    Gorard, Stephen; See, Beng Huat; Siddiqui, Nadia; Smith, Emma; White, Patrick

    2016-01-01

    The intervention evaluated here is one of two "youth social action" projects jointly funded by the Education Endowment Foundation, the U.K. Cabinet Office, the Pears Foundation and the Stone Family Foundation. It was delivered by the Youth United Foundation (YUF) and involved uniformed youth organisations being established in schools in…

  10. GROWTH INHIBITORY ACTIONS OF PROTHROMBIN ON NORMAL HEPATOCYTES

    PubMed Central

    Carr, Brian I.; Kar, Siddhartha; Wang, Meifang; Wang, Ziqiu

    2007-01-01

    Most hepatomas have a defect in prothrombin carboxylation, and can secrete under-carboxylated prothrombin or des-γ-carboxy-prothrombin (DCP), the function of which is unknown. We considered that prothrombin-DCP axis might also be involved in growth control. Hepatocytes and hepatoma cells were treated with prothrombin, and DNA synthesis and cytoskeleton were studied. Prothrombin inhibited DNA synthesis in hepatocytes on fibronectin, but not collagen matrix. Hepatoma cell lines were not inhibited. We found that hepatoma cell matrix conferred resistance to hepatocytes. Prothrombin decreased fibronectin but not collagen amounts, but only in the presence of hepatocytes and not hepatoma cells, indicating that it has a differential action on matrix proteins. It also caused changes in cell shape and actin depolymerization. In vivo, there was a decrease in plasma prothrombin activity after a partial hepatectomy (PH) concomitant with a peak of DNA synthesis by the hepatocyte at 24 h after PH. Injection of warfarin at the time of PH, further inhibited PT activity and enhanced this 24 h peak of DNA synthesis. Furthermore, repeated injection of prothrombin lowered the peak DNA synthesis after PH. The data support the hypothesis that prothrombin can act as a hepatocyte growth inhibitor, likely at the level of fibronectin loss and result in cytoskeletal changes. Hepatomas resist this action, possibly due to their different matrix proteins. This represents a novel mechanism for growth regulation and provides a possible biological significance for the tumor marker DCP. PMID:17490900

  11. 75 FR 65052 - Notice of Final Federal Agency Actions on Proposed Highway in California

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-21

    ... of Limitation on Claims for Judicial Review of Actions by the California Department of Transportation (Caltrans), pursuant to 23 U.S.C. 327. SUMMARY: The FHWA, on behalf of Caltrans, is issuing this notice to announce actions taken by Caltrans and other Federal agencies that are final within the meaning of 23 U.S.C...

  12. 75 FR 32835 - Notice of Final Federal Agency Actions on Proposed Highway in California

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-09

    ... 23 U.S.C. 139(l)(1). A claim seeking judicial review of the Federal agency actions on the highway... of Limitation on Claims for Judicial Review of Actions by the California Department of Transportation (Caltrans), pursuant to 23 U.S.C. 327. SUMMARY: The FHWA, on behalf of Caltrans, is issuing this notice to...

  13. 75 FR 5168 - Notice of Final Federal Agency Action on Proposed Highway in Illinois

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-01

    ... limitation on claims for judicial review of actions by FHWA and other Federal agencies. SUMMARY: This notice... construction of an access-controlled, four-lane freeway on new right-of-way between the existing IL 6... final agency actions subject to 23 U.S.C. 139(l)(1). A claim seeking judicial review of the Federal...

  14. 76 FR 36614 - Notice of Final Federal Agency Action on Proposed Highway in Illinois

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-22

    ... limitation on claims for judicial review of actions by FHWA and other Federal agencies. SUMMARY: This notice... construction of an access-controlled, four- lane expressway on new right-of-way between the proposed Macomb... 23 U.S.C. 139(l)(1). A claim seeking judicial review of the Federal agency actions of the highway...

  15. Spiralling towards Transformational Action Research: Philosophical and Practical Journeys

    ERIC Educational Resources Information Center

    Titchen, Angie; Manley, Kim

    2006-01-01

    The two-stranded spiral shown in Figure 1 represents two aspects of the authors' journey in becoming critical. The journey, conveyed through discussion, reflexive accounts and illustrations of particular and summary achievements, shows how Carr and Kemmis's work has influenced the authors as action researchers, both individually and together, in…

  16. 78 FR 23630 - Notice of Final Federal Agency Actions on State Highway 99 (Segment C) in Texas

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-19

    ...: Notice of Limitation on Claims for Judicial Review of Actions by FHWA and Other Federal Agencies. SUMMARY... public of final agency actions subject to 23 U.S.C. 139(l)(1). A claim seeking judicial review of the Federal agency actions on the highway project will be barred unless the claim is filed on or before...

  17. 75 FR 43160 - Clean Water Act Section 303(d): Final Agency Action on One Arkansas Total Maximum Daily Load (TMDL)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-23

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9179-3 ] Clean Water Act Section 303(d): Final Agency Action on One Arkansas Total Maximum Daily Load (TMDL) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of availability. SUMMARY: This notice announces the final agency action on one TMDL established by...

  18. 75 FR 28282 - Notice of Realty Action; Recreation and Public Purposes Act Classification; Lease and Conveyance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-20

    ... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLAZC01000.L14300000.ES0000.241A, AZA 34298... Public Land; Arizona AGENCY: Bureau of Land Management, Interior. ACTION: Notice of Realty Action. SUMMARY: The Mohave County Community College District (College) filed an application to lease/purchase...

  19. SevenOperators, a Mathematica script for harmonic oscillator nuclear matrix elements arising in semileptonic electroweak interactions

    NASA Astrophysics Data System (ADS)

    Haxton, Wick; Lunardini, Cecilia

    2008-09-01

    Semi-leptonic electroweak interactions in nuclei—such as β decay, μ capture, charged- and neutral-current neutrino reactions, and electron scattering—are described by a set of multipole operators carrying definite parity and angular momentum, obtained by projection from the underlying nuclear charge and three-current operators. If these nuclear operators are approximated by their one-body forms and expanded in the nucleon velocity through order |p→|/M, where p→ and M are the nucleon momentum and mass, a set of seven multipole operators is obtained. Nuclear structure calculations are often performed in a basis of Slater determinants formed from harmonic oscillator orbitals, a choice that allows translational invariance to be preserved. Harmonic-oscillator single-particle matrix elements of the multipole operators can be evaluated analytically and expressed in terms of finite polynomials in q, where q is the magnitude of the three-momentum transfer. While results for such matrix elements are available in tabular form, with certain restriction on quantum numbers, the task of determining the analytic form of a response function can still be quite tedious, requiring the folding of the tabulated matrix elements with the nuclear density matrix, and subsequent algebra to evaluate products of operators. Here we provide a Mathematica script for generating these matrix elements, which will allow users to carry out all such calculations by symbolic manipulation. This will eliminate the errors that may accompany hand calculations and speed the calculation of electroweak nuclear cross sections and rates. We illustrate the use of the new script by calculating the cross sections for charged- and neutral-current neutrino scattering in 12C. Program summaryProgram title: SevenOperators Catalogue identifier: AEAY_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEAY_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland

  20. 78 FR 13746 - Notice of Final Federal Agency Actions on Proposed Highway in California

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ... public of final agency actions subject to 23 U.S.C. 139(l)(1). A claim seeking judicial review of the... of Limitation on Claims for Judicial Review of Actions by the California Department of Transportation (Caltrans), pursuant to 23 U.S.C. 327. SUMMARY: The FHWA, on behalf of Caltrans, is issuing this notice to...

  1. 77 FR 5617 - Notice of Final Federal Agency Action on Proposed Highway in Utah

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-03

    ... Limitations on Claims for Judicial Review of Actions by FHWA and other Federal Agencies. SUMMARY: This notice... subject to 23 U.S.C. 139(I)(1). A claim seeking judicial review of the FHWA actions on the highway project will be barred unless the claim is filed on or before August 1, 2012. If the Federal law that...

  2. CARTILAGE OLIGOMERIC MATRIX PROTEIN ENHANCES MATRIX ASSEMBLY DURING CHONDROGENESIS OF HUMAN MESENCHYMAL STEM CELLS

    PubMed Central

    Haleem-Smith, Hana; Calderon, Raul; Song, Yingjie; Tuan, Rocky S.; Chen, Faye H.

    2011-01-01

    Cartilage oligomeric matrix protein/thrombospondin-5 (COMP/TSP5) is an abundant cartilage extracellular matrix (ECM) protein that interacts with major cartilage ECM components, including aggrecan and collagens. To test our hypothesis that COMP/TSP5 functions in the assembly of the ECM during cartilage morphogenesis, we have employed mesenchymal stem cell (MSC) chondrogenesis in vitro as a model to examine the effects of COMP over-expression on neo-cartilage formation. Human bone marrow-derived MSCs were transfected with either full-length COMP cDNA or control plasmid, followed by chondrogenic induction in three-dimensional pellet or alginate-hydrogel culture. MSC chondrogenesis and ECM production was estimated based on quantitation of sulfated glycosaminoglycan (sGAG) accumulation, immunohistochemistry of the presence and distribution of cartilage ECM proteins, and real-time RT-PCR analyis of mRNA expression of cartilage markers. Our results showed that COMP over-expression resulted in increased total sGAG content during the early phase of MSC chondrogenesis, and increased immuno-detectable levels of aggrecan and collagen type II in the ECM of COMP-transfected pellet and alginate cultures, indicating more abundant cartilaginous matrix. COMP transfection did not significantly increase the transcript levels of the early chondrogenic marker, Sox9, or aggrecan, suggesting that enhancement of MSC cartilage ECM was effected at post-transcriptional levels. These findings strongly suggest that COMP functions in mesenchymal chondrogenesis by enhancing cartilage ECM organization and assembly. The action of COMP is most likely mediated not via direct changes in cartilage matrix gene expression but via interactions of COMP with other cartilage ECM proteins, such as aggrecan and collagens, that result in enhanced assembly and retention. PMID:22095699

  3. Matrix completion by deep matrix factorization.

    PubMed

    Fan, Jicong; Cheng, Jieyu

    2018-02-01

    Conventional methods of matrix completion are linear methods that are not effective in handling data of nonlinear structures. Recently a few researchers attempted to incorporate nonlinear techniques into matrix completion but there still exists considerable limitations. In this paper, a novel method called deep matrix factorization (DMF) is proposed for nonlinear matrix completion. Different from conventional matrix completion methods that are based on linear latent variable models, DMF is on the basis of a nonlinear latent variable model. DMF is formulated as a deep-structure neural network, in which the inputs are the low-dimensional unknown latent variables and the outputs are the partially observed variables. In DMF, the inputs and the parameters of the multilayer neural network are simultaneously optimized to minimize the reconstruction errors for the observed entries. Then the missing entries can be readily recovered by propagating the latent variables to the output layer. DMF is compared with state-of-the-art methods of linear and nonlinear matrix completion in the tasks of toy matrix completion, image inpainting and collaborative filtering. The experimental results verify that DMF is able to provide higher matrix completion accuracy than existing methods do and DMF is applicable to large matrices. Copyright © 2017 Elsevier Ltd. All rights reserved.

  4. International Perspectives on Affirmative Action. A Bellagio Conference (Lake Como, Italy, August 16-20, 1982).

    ERIC Educational Resources Information Center

    Rockefeller Foundation, New York, NY.

    This volume presents nine papers read at a conference on affirmative action, sponsored by the Rockefeller Foundation and held at Columbia University in August 1982; a preface, summary paper, and list of participants are also included. Each paper addresses the issue of affirmative action within a different country and describes: (1) the policies…

  5. 75 FR 80107 - Notice of Statute of Limitations on Claims; Notice of Final Federal Agency Actions on Proposed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-21

    ... Administration (FHWA), DOT. ACTION: Notice of Limitation on Claims for Judicial Review of Actions by the California Department of Transportation (Caltrans), pursuant to 23 U.S.C. 327. SUMMARY: The FHWA, on behalf... meaning of 23 U.S.C. 139(l)(1). The actions relate to a proposed highway project, the State Route 2...

  6. [Extracellular matrix--regulation of cancer invasion and metastasis].

    PubMed

    Watanabe, Hideto

    2010-11-01

    Cancer cell invasion comprises steps in the destruction of the basement membrane and migration of cells into the connective tissue. These cells further migrate into lymph ducts and small vessels to reach metastasis. The extracellular matrix (ECM) provides a microenvironment for cells, and its destruction is associated with cancer cell invasion. Among matrix metalloproteinases (MMPs), both MMP-2 and 9 digest type IV collagen, a major component of the basement membrane, and MMP-14/MT1-MMP, a membrane-type MMP, activates MMP-2. Thus, these MMPs play a central role in cancer cell invasion. MMPs also cleave latent forms of growth factors and signaling molecules, releasing and activating them, which influence neo-vascularization and cancer apoptosis. Like proteins, carbohydrates are known to be involved in cancer invasion. Hyaluronan is known to both stimulate and inhibit cancer invasion, depending on its molecular size. Heparanase, which digests heparan sulfate, is known to facilitate cancer invasion and metastasis. In summary, ECM provides a microenvironment that regulates cell behavior and its structure altered by MMPs affects cancer cell invasion.

  7. Short-distance matrix elements for $D$-meson mixing for 2+1 lattice QCD

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chang, Chia Cheng

    2015-01-01

    We study the short-distance hadronic matrix elements for D-meson mixing with partially quenched N f = 2+1 lattice QCD. We use a large set of the MIMD Lattice Computation Collaboration's gauge configurations with a 2 tadpole-improved staggered sea quarks and tadpole-improved Lüscher-Weisz gluons. We use the a 2 tadpole-improved action for valence light quarks and the Sheikoleslami-Wohlert action with the Fermilab interpretation for the valence charm quark. Our calculation covers the complete set of five operators needed to constrain new physics models for D-meson mixing. We match our matrix elements to the MS-NDR scheme evaluated at 3 GeV. We reportmore » values for the Beneke-Buchalla-Greub-Lenz-Nierste choice of evanescent operators.« less

  8. Social Justice through Literacy: Integrating Digital Video Cameras in Reading Summaries and Responses

    ERIC Educational Resources Information Center

    Liu, Rong; Unger, John A.; Scullion, Vicki A.

    2014-01-01

    Drawing data from an action-oriented research project for integrating digital video cameras into the reading process in pre-college courses, this study proposes using digital video cameras in reading summaries and responses to promote critical thinking and to teach social justice concepts. The digital video research project is founded on…

  9. New Mexico state information handbook: formerly utilized sites remedial action program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of New Mexico. It contains a description ofmore » the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.« less

  10. Your Right to Clean Air, A Manual for Citizen Action.

    ERIC Educational Resources Information Center

    1970

    This manual provides the citizen with basic information for taking action against air pollution. A summary of the effects of various concentrations of sulfur oxides, particulate matter, carbon monoxide, photochemical smog, and hydrocarbons is presented. Suggestions are made for obtaining information about community air pollution problems, and how…

  11. Anti‐fibrotic actions of relaxin

    PubMed Central

    Royce, S G; Hewitson, T D; Denton, K M; Cooney, T E

    2016-01-01

    Abstract Fibrosis refers to the hardening or scarring of tissues that usually results from aberrant wound healing in response to organ injury, and its manifestations in various organs have collectively been estimated to contribute to around 45–50% of deaths in the Western world. Despite this, there is currently no effective cure for the tissue structural and functional damage induced by fibrosis‐related disorders. Relaxin meets several criteria of an effective anti‐fibrotic based on its specific ability to inhibit pro‐fibrotic cytokine and/or growth factor‐mediated, but not normal/unstimulated, fibroblast proliferation, differentiation and matrix production. Furthermore, relaxin augments matrix degradation through its ability to up‐regulate the release and activation of various matrix‐degrading matrix metalloproteinases and/or being able to down‐regulate tissue inhibitor of metalloproteinase activity. Relaxin can also indirectly suppress fibrosis through its other well‐known (anti‐inflammatory, antioxidant, anti‐hypertrophic, anti‐apoptotic, angiogenic, wound healing and vasodilator) properties. This review will outline the organ‐specific and general anti‐fibrotic significance of exogenously administered relaxin and its mechanisms of action that have been documented in various non‐reproductive organs such as the cardiovascular system, kidney, lung, liver, skin and tendons. In addition, it will outline the influence of sex on relaxin's anti‐fibrotic actions, highlighting its potential as an emerging anti‐fibrotic therapeutic. Linked Articles This article is part of a themed section on Recent Progress in the Understanding of Relaxin Family Peptides and their Receptors. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.10/issuetoc PMID:27250825

  12. A system review of the Virginia Alcohol Safety Action Program : executive summary.

    DOT National Transportation Integrated Search

    1980-01-01

    In March 1979, the Virginia General Assembly gave the Virginia Department of Transportation Safety (VDTS) the power and responsibility to make binding policy and set standards for the local Virginia Alcohol Safety Action Projects across the state. In...

  13. 76 FR 74805 - Notice of Realty Action; Recreation and Public Purposes Act Classification; Tenakee Springs, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-01

    ... DEPARTMENT OF THE INTERIOR Bureau of Land Management [AKA01300.L14100000.ES0000; AA-092370, and AA... AGENCY: Bureau of Land Management, Interior. ACTION: Notice of realty action. SUMMARY: The Bureau of Land Management (BLM) examined approximately 0.31 acres of public land in Alaska and found it suitable for...

  14. Bone Formation is Affected by Matrix Advanced Glycation End Products (AGEs) In Vivo.

    PubMed

    Yang, Xiao; Mostafa, Ahmed Jenan; Appleford, Mark; Sun, Lian-Wen; Wang, Xiaodu

    2016-10-01

    Advanced glycation end products (AGEs) accumulate in bone extracellular matrix as people age. Although previous evidence shows that the accumulation of AGEs in bone matrix may impose significant effects on bone cells, the effect of matrix AGEs on bone formation in vivo is still poorly understood. To address this issue, this study used a unique rat model with autograft implant to investigate the in vivo response of bone formation to matrix AGEs. Fluorochrome biomarkers were sequentially injected into rats to label the dynamic bone formation in the presence of elevated levels of matrix AGEs. After sacrificing animals, dynamic histomorphometry was performed to determine mineral apposition rate (MAR), mineralized surface per bone surface (MS/BS), and bone formation rate (BFR). Finally, nanoindentation tests were performed to assess mechanical properties of newly formed bone tissues. The results showed that MAR, MS/BS, and BFR were significantly reduced in the vicinity of implant cores with high concentration of matrix AGEs, suggesting that bone formation activities by osteoblasts were suppressed in the presence of elevated matrix AGEs. In addition, MAR and BFR were found to be dependent on the surrounding environment of implant cores (i.e., cortical or trabecular tissues). Moreover, MS/BS and BFR were also dependent on how far the implant cores were away from the growth plate. These observations suggest that the effect of matrix AGEs on bone formation is dependent on the biological milieu around the implants. Finally, nanoindentation test results indicated that the indentation modulus and hardness of newly formed bone tissues were not affected by the presence of elevated matrix AGEs. In summary, high concentration of matrix AGEs may slow down the bone formation process in vivo, while imposing little effects on bone mineralization.

  15. New Jersey state information handbook: Formerly Utilized Sites Remedial Action Program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    Under the implied authority of the Atomic Energy Act of 1954, as amended, radiological surveys and research work has been conducted to determine radiological conditions at former MED/AEC sites. As of this time, 31 sites in 13 states have been identified that require or may require remedial action. This volume is one of a series produced under contract with DOE, Office of Nuclear Waste Management, by POLITECH CORPORATION to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Remedial Action Program. This Information Handbook seriesmore » contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the state of New Jersey. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations. The loose-leaf format used in these volumes will allow the material to be updated periodically as the Remedial Action Program progresses.« less

  16. Modeling extracellular matrix degradation balance with proteinase/transglutaminase cycle.

    PubMed

    Larreta-Garde, Veronique; Berry, Hugues

    2002-07-07

    Extracellular matrix mass balance is implied in many physiological and pathological events, such as metastasis dissemination. Widely studied, its destructive part is mainly catalysed by extracellular proteinases. Conversely, the properties of the constructive part are less obvious, cellular neo-synthesis being usually considered as its only element. In this paper, we introduce the action of transglutaminase in a mathematical model for extracellular matrix remodeling. This extracellular enzyme, catalysing intermolecular protein cross-linking, is considered here as a reverse proteinase as far as the extracellular matrix physical state is concerned. The model is based on a proteinase/transglutaminase cycle interconverting insoluble matrix and soluble proteolysis fragments, with regulation of cellular proteinase expression by the fragments. Under "closed" (batch) conditions, i.e. neglecting matrix influx and fragment efflux from the system, the model is bistable, with reversible hysteresis. Extracellular matrix proteins concentration abruptly switches from low to high levels when transglutaminase activity exceeds a threshold value. Proteinase concentration usually follows the reverse complementary kinetics, but can become apparently uncoupled from extracellular matrix concentration for some parameter values. When matrix production by the cells and fragment degradation are taken into account, the dynamics change to sustained oscillations because of the emergence of a stable limit cycle. Transitions out of and into oscillation areas are controlled by the model parameters. Biological interpretation indicates that these oscillations could represent the normal homeostatic situation, whereas the other exhibited dynamics can be related to pathologies such as tumor invasion or fibrosis. These results allow to discuss the insights that the model could contribute to the comprehension of these complex biological events.

  17. Fructose toxicity: is the science ready for public health actions?

    PubMed Central

    Tappy, Luc; Mittendorfer, Bettina

    2013-01-01

    Summary Purpose of review The assumption that fructose may be “toxic” and involved in the pathogenesis of non communicable diseases such as obesity, diabetes mellitus, dyslipidemia, and even cancer has resulted in the call for public health action, such as introducing taxes on sweetened beverages. This review evaluates the scientific basis for such action. Recent findings Although some studies hint towards some potential adverse effects of excessive fructose consumption especially when combined with excess energy intake, the results from clinical trials do not support a significant detrimental effect of fructose on metabolic health when consumed as part of a weight maintaining diet in amounts consistent with the average estimated fructose consumption in Western countries. However, definitive studies are missing. Summary and conclusion Public health policies to eliminate or limit fructose in the diet should be considered premature. Instead, efforts should be made to promote a healthy life style that includes physical activity and nutritious foods while avoiding intake of excess calories until solid evidence to support action against fructose is available. Public health is almost certainly to benefit more from policies that are aimed at promoting what is known to be good than from policies that are prohibiting what is not (yet) known to be bad. PMID:22617566

  18. 29 CFR 102.67 - Proceedings before the regional director; further hearing; briefs; action by the regional...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... as a stay of the election or any action taken or directed by the regional director: Provided, however... request must contain a summary of all evidence or rulings bearing on the issues together with page... secret ballot of the employees or the appropriate action to be taken on impounded ballots of an election...

  19. 29 CFR 102.67 - Proceedings before the regional director; further hearing; briefs; action by the regional...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... as a stay of the election or any action taken or directed by the regional director: Provided, however... request must contain a summary of all evidence or rulings bearing on the issues together with page... secret ballot of the employees or the appropriate action to be taken on impounded ballots of an election...

  20. Eighth International Chorea-Acanthocytosis Symposium: Summary of Workshop Discussion and Action Points.

    PubMed

    Pappas, Samuel S; Bonifacino, Juan; Danek, Adrian; Dauer, William T; De, Mithu; De Franceschi, Lucia; DiPaolo, Gilbert; Fuller, Robert; Haucke, Volker; Hermann, Andreas; Kornmann, Benoit; Landwehrmeyer, Bernhard; Levin, Johannes; Neiman, Aaron M; Rudnicki, Dobrila D; Sibon, Ody; Velayos-Baeza, Antonio; Vonk, Jan J; Walker, Ruth H; Weisman, Lois S; Albin, Roger L

    2017-01-01

    Chorea-Acanthocytosis (ChAc) is a rare hereditary neurological disorder characterized by abnormal movements, red blood cell pathology, and progressive neurodegeneration. Little is understood of the pathogenesis of ChAc and related disorders (collectively Neuroacanthocytosis). The Eighth International Chorea-Acanthocytosis Symposium was held in May 2016 in Ann Arbor, MI, USA, and focused on molecular mechanisms driving ChAc pathophysiology. Accompanying the meeting, members of the neuroacanthocytosis research community and other invited scientists met in a workshop to discuss the current understanding and next steps needed to better understand ChAc pathogenesis. These discussions identified several broad and critical needs for advancing ChAc research and patient care, and led to the definition of 18 specific action points related to functional and molecular studies, animal models, and clinical research. These action points, described below, represent tractable research goals to pursue for the next several years.

  1. DATA SUMMARY REPORT SMALL SCALE MELTER TESTING OF HLW ALGORITHM GLASSES MATRIX1 TESTS VSL-07S1220-1 REV 0 7/25/07

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    KRUGER AA; MATLACK KS; PEGG IL

    2011-12-29

    Eight tests using different HLW feeds were conducted on the DM100-BL to determine the effect of variations in glass properties and feed composition on processing rates and melter conditions (off-gas characteristics, glass processing, foaming, cold cap, etc.) at constant bubbling rate. In over seven hundred hours of testing, the property extremes of glass viscosity, electrical conductivity, and T{sub 1%}, as well as minimum and maximum concentrations of several major and minor glass components were evaluated using glass compositions that have been tested previously at the crucible scale. Other parameters evaluated with respect to glass processing properties were +/-15% batching errorsmore » in the addition of glass forming chemicals (GFCs) to the feed, and variation in the sources of boron and sodium used in the GFCs. Tests evaluating batching errors and GFC source employed variations on the HLW98-86 formulation (a glass composition formulated for HLW C-106/AY-102 waste and processed in several previous melter tests) in order to best isolate the effect of each test variable. These tests are outlined in a Test Plan that was prepared in response to the Test Specification for this work. The present report provides summary level data for all of the tests in the first test matrix (Matrix 1) in the Test Plan. Summary results from the remaining tests, investigating minimum and maximum concentrations of major and minor glass components employing variations on the HLW98-86 formulation and glasses generated by the HLW glass formulation algorithm, will be reported separately after those tests are completed. The test data summarized herein include glass production rates, the type and amount of feed used, a variety of measured melter parameters including temperatures and electrode power, feed sample analysis, measured glass properties, and gaseous emissions rates. More detailed information and analysis from the melter tests with complete emission chemistry, glass durability

  2. 78 FR 34015 - Petition for Reconsideration of Action in Rulemaking Proceeding

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ... FEDERAL COMMUNICATIONS COMMISSION 47 CFR Parts 1, 2, 20, 22, 24, 27, 90 and 95 [WT Docket No. 10-4... Communications Commission. ACTION: Petition for reconsideration. SUMMARY: In this document, Petitions for... Communications Commission, 445 12th Street SW., Washington, DC 20554. FOR FURTHER INFORMATION CONTACT: Joyce...

  3. Toric Calabi-Yau threefolds as quantum integrable systems. R-matrix and RTT relations

    NASA Astrophysics Data System (ADS)

    Awata, Hidetoshi; Kanno, Hiroaki; Mironov, Andrei; Morozov, Alexei; Morozov, Andrey; Ohkubo, Yusuke; Zenkevich, Yegor

    2016-10-01

    R-matrix is explicitly constructed for simplest representations of the Ding-Iohara-Miki algebra. Calculation is straightforward and significantly simpler than the one through the universal R-matrix used for a similar calculation in the Yangian case by A. Smirnov but less general. We investigate the interplay between the R-matrix structure and the structure of DIM algebra intertwiners, i.e. of refined topological vertices and show that the R-matrix is diagonalized by the action of the spectral duality belonging to the SL(2, ℤ) group of DIM algebra automorphisms. We also construct the T-operators satisfying the RTT relations with the R-matrix from refined amplitudes on resolved conifold. We thus show that topological string theories on the toric Calabi-Yau threefolds can be naturally interpreted as lattice integrable models. Integrals of motion for these systems are related to q-deformation of the reflection matrices of the Liouville/Toda theories.

  4. 76 FR 40046 - Unified Agenda of Federal Regulatory and Deregulatory Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    .... ACTION: Semiannual regulatory agenda. SUMMARY: The Secretary of Education publishes a semiannual agenda..., 1993, requires the Department of Education (ED) to publish, at a time and in a manner specified by the... ED to publish, in October and April of each year, a regulatory flexibility agenda. The regulatory...

  5. 2DRMP: A suite of two-dimensional R-matrix propagation codes

    NASA Astrophysics Data System (ADS)

    Scott, N. S.; Scott, M. P.; Burke, P. G.; Stitt, T.; Faro-Maza, V.; Denis, C.; Maniopoulou, A.

    2009-12-01

    The R-matrix method has proved to be a remarkably stable, robust and efficient technique for solving the close-coupling equations that arise in electron and photon collisions with atoms, ions and molecules. During the last thirty-four years a series of related R-matrix program packages have been published periodically in CPC. These packages are primarily concerned with low-energy scattering where the incident energy is insufficient to ionise the target. In this paper we describe 2DRMP, a suite of two-dimensional R-matrix propagation programs aimed at creating virtual experiments on high performance and grid architectures to enable the study of electron scattering from H-like atoms and ions at intermediate energies. Program summaryProgram title: 2DRMP Catalogue identifier: AEEA_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEEA_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 196 717 No. of bytes in distributed program, including test data, etc.: 3 819 727 Distribution format: tar.gz Programming language: Fortran 95, MPI Computer: Tested on CRAY XT4 [1]; IBM eServer 575 [2]; Itanium II cluster [3] Operating system: Tested on UNICOS/lc [1]; IBM AIX [2]; Red Hat Linux Enterprise AS [3] Has the code been vectorised or parallelised?: Yes. 16 cores were used for small test run Classification: 2.4 External routines: BLAS, LAPACK, PBLAS, ScaLAPACK Subprograms used: ADAZ_v1_1 Nature of problem: 2DRMP is a suite of programs aimed at creating virtual experiments on high performance architectures to enable the study of electron scattering from H-like atoms and ions at intermediate energies. Solution method: Two-dimensional R-matrix propagation theory. The (r,r) space of the internal region is subdivided into a number of subregions. Local R-matrices are constructed

  6. Higher Rank ABJM Wilson Loops from Matrix Models

    NASA Astrophysics Data System (ADS)

    Cookmeyer, Jonathan; Liu, James; Zayas, Leopoldo

    2017-01-01

    We compute the expectation values of 1/6 supersymmetric Wilson Loops in ABJM theory in higher rank representations. Using standard matrix model techniques, we calculate the expectation value in the rank m fully symmetric and fully antisymmetric representation where m is scaled with N. To leading order, we find agreement with the classical action of D6 and D2 branes in AdS4 ×CP3 respectively. Further, we compute the first subleading order term, which, on the AdS side, makes a prediction for the one-loop effective action of the corresponding D6 and D2 branes. Supported by the National Science Foundation under Grant No. PHY 1559988 and the US Department of Energy under Grant No. DE-SC0007859.

  7. DNA and proteins of the nuclear matrix are the main targets of benzo[a]pyrene's action in rat hepatocytes.

    PubMed

    Widłak, P; Rzeszowska-Wolny, J

    1993-01-01

    The binding of [14C]benzo[a]pyrene (B[a]P) to DNA and proteins in total nuclei and subnuclear fractions of cultured rat hepatocytes was compared. The main targets of B[a]P were non-histone high molecular weight proteins of the nuclear matrix and DNA sequences attached to this structure. Following 24 h exposure to B[a]P the amounts of adducts in the nuclear matrix DNA and proteins were twice as high as in total nuclei. After withdrawal of the carcinogen containing medium the level of B[a]P-induced adducts gradually decreased but always remained the highest in the nuclear matrix proteins. Removal of adducts from the nuclear matrix DNA was more efficient than from the other DNA fractions, and 72 h after exposure to the carcinogen the level of DNA adducts in this fraction was similar to that in total nuclei.

  8. Concomitant use of the matrix strategy and the mand-model procedure in teaching graphic symbol combinations.

    PubMed

    Nigam, Ravi; Schlosser, Ralf W; Lloyd, Lyle L

    2006-09-01

    Matrix strategies employing parts of speech arranged in systematic language matrices and milieu language teaching strategies have been successfully used to teach word combining skills to children who have cognitive disabilities and some functional speech. The present study investigated the acquisition and generalized production of two-term semantic relationships in a new population using new types of symbols. Three children with cognitive disabilities and little or no functional speech were taught to combine graphic symbols. The matrix strategy and the mand-model procedure were used concomitantly as intervention procedures. A multiple probe design across sets of action-object combinations with generalization probes of untrained combinations was used to teach the production of graphic symbol combinations. Results indicated that two of the three children learned the early syntactic-semantic rule of combining action-object symbols and demonstrated generalization to untrained action-object combinations and generalization across trainers. The results and future directions for research are discussed.

  9. Biodegradable magnesium-hydroxyapatite metal matrix composites.

    PubMed

    Witte, Frank; Feyerabend, Frank; Maier, Petra; Fischer, Jens; Störmer, Michael; Blawert, Carsten; Dietzel, Wolfgang; Hort, Norbert

    2007-04-01

    Recent studies indicate that there is a high demand to design magnesium alloys with adjustable corrosion rates and suitable mechanical properties. An approach to this challenge might be the application of metal matrix composite (MMC) based on magnesium alloys. In this study, a MMC made of magnesium alloy AZ91D as a matrix and hydroxyapatite (HA) particles as reinforcements have been investigated in vitro for mechanical, corrosive and cytocompatible properties. The mechanical properties of the MMC-HA were adjustable by the choice of HA particle size and distribution. Corrosion tests revealed that HA particles stabilised the corrosion rate and exhibited more uniform corrosion attack in artificial sea water and cell solutions. The phase identification showed that all samples contained hcp-Mg, Mg(17)Al(12), and HA before and after immersion. After immersion in artificial sea water CaCO3 was found on MMC-HA surfaces, while no formation of CaCO3 was found after immersion in cell solutions with and without proteins. Co-cultivation of MMC-HA with human bone derived cells (HBDC), cells of an osteoblasts lineage (MG-63) and cells of a macrophage lineage (RAW264.7) revealed that RAW264.7, MG-63 and HBDC adhere, proliferate and survive on the corroding surfaces of MMC-HA. In summary, biodegradable MMC-HA are cytocompatible biomaterials with adjustable mechanical and corrosive properties.

  10. Asymptotics of action variables near semi-toric singularities

    NASA Astrophysics Data System (ADS)

    Wacheux, Christophe

    2015-12-01

    The presence of focus-focus singularities in semi-toric integrables Hamiltonian systems is one of the reasons why there cannot exist global Action-Angle coordinates on such systems. At focus-focus critical points, the Liouville-Arnold-Mineur theorem does not apply. In particular, the affine structure of the image of the moment map around has non-trivial monodromy. In this article, we establish that the singular behavior and the multi-valuedness of the Action integrals is given by a complex logarithm. This extends a previous result by San Vũ Ngọc to any dimension. We also calculate the monodromy matrix for these systems.

  11. Bone matrix to growth factors: location, location, location

    PubMed Central

    Todorovic, Vesna

    2010-01-01

    The demonstration that fibrillin-1 mutations perturb transforming growth factor (TGF)–β bioavailability/signaling in Marfan syndrome (MFS) changed the view of the extracellular matrix as a passive structural support to a dynamic modulator of cell behavior. In this issue, Nistala et al. (2010. J. Cell Biol. doi: 10.1083/jcb.201003089) advance this concept by demonstrating how fibrillin-1 and -2 regulate TGF-β and bone morphogenetic protein (BMP) action during osteoblast maturation. PMID:20855500

  12. The matrix approach to mental health care: Experiences in Florianopolis, Brazil.

    PubMed

    Soares, Susana; de Oliveira, Walter Ferreira

    2016-03-01

    This article reports on the experience of a matrix approach to mental health in primary health care. Professionals who work in the Family Health Support Nuclei, Núcleos de Apoio à Saúde da Família, pointed to challenges of this approach, especially regarding the difficulties of introducing pedagogic actions in the health field and problems related to work relationships. As the matrix approach and its practice are new aspects of the Brazilian Unified Health System, the academic knowledge must walk hand in hand with everyday professional practice to help improve the quality of the services offered in this context. © The Author(s) 2016.

  13. Human health exposure assessment for Rocky Mountain Arsenal. Volume 7. Summary exposure assessment version 4. 1. Final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    The objectives of the Human Health Exposure Assessment include: (1) estimate the type and magnitude of exposures to contaminants; (2) Identify contaminants of concern; (3) Identify sites for remedial action; (4) Recommend sites for the no action remedial alternative; and (5) Provide a basis for detailed characterization of the risk associated with all sites. This document consists of the following: An executive summary. Vol I - Land use and exposed population evaluations. Vol. II III - Toxicity assessment (includes army and shell toxicity profiles). Vol. IV - PPLV Methodology. Vol. V - PPLV Calculations. Vol. VI - Study area exposuremore » analysis A introduction, B Western study ares, C Southern study area, D northern Central study area, E Central study area, F Eastern study area, G South plants study area, and H North plants study area. Vol. VII - Summary exposure assessment.« less

  14. Case studies: the impact of nonanalyte components on LC-MS/MS-based bioanalysis: strategies for identifying and overcoming matrix effects.

    PubMed

    Li, Fumin; Ewles, Matthew; Pelzer, Mary; Brus, Theodore; Ledvina, Aaron; Gray, Nicholas; Koupaei-Abyazani, Mohammad; Blackburn, Michael

    2013-10-01

    Achieving sufficient selectivity in bioanalysis is critical to ensure accurate quantitation of drugs and metabolites in biological matrices. Matrix effects most classically refer to modification of ionization efficiency of an analyte in the presence of matrix components. However, nonanalyte or matrix components present in samples can adversely impact the performance of a bioanalytical method and are broadly considered as matrix effects. For the current manuscript, we expand the scope to include matrix elements that contribute to isobaric interference and measurement bias. These three categories of matrix effects are illustrated with real examples encountered. The causes, symptoms, and suggested strategies and resolutions for each form of matrix effects are discussed. Each case is presented in the format of situation/action/result to facilitate reading.

  15. 77 FR 70955 - FDA Actions Related to Nicotine Replacement Therapies and Smoking-Cessation Products; Report to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-28

    .... FDA-2012-N-1148] FDA Actions Related to Nicotine Replacement Therapies and Smoking-Cessation Products... comments. SUMMARY: The Food and Drug Administration (FDA) is announcing a 1-day public hearing to obtain...

  16. A Delphi-matrix approach to SEA and its application within the tourism sector in Taiwan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kuo, N.-W.; Hsiao, T.-Y.; Yu, Y.-H.

    Strategic Environmental Assessment (SEA) is a procedural tool and within the framework of SEA, several different types of analytical methods can be used in the assessment. However, the impact matrix used currently in Taiwan has some disadvantages. Hence, a Delphi-matrix approach to SEA is proposed here to improve the performance of Taiwan's SEA. This new approach is based on the impact matrix combination with indicators of sustainability, and then the Delphi method is employed to collect experts' opinions. In addition, the assessment of National Floriculture Park Plan and Taiwan Flora 2008 Program is taken as an example to examine thismore » new method. Although international exhibition is one of the important tourism (economic) activities, SEA is seldom about tourism sector. Finally, the Delphi-matrix approach to SEA for tourism development plan is established containing eight assessment topics and 26 corresponding categories. In summary, three major types of impacts: resources' usages, pollution emissions, and local cultures change are found. Resources' usages, such as water, electricity, and natural gas demand, are calculated on a per capita basis. Various forms of pollution resulting from this plan, such as air, water, soil, waste, and noise, are also identified.« less

  17. Matrix product operators, matrix product states, and ab initio density matrix renormalization group algorithms

    NASA Astrophysics Data System (ADS)

    Chan, Garnet Kin-Lic; Keselman, Anna; Nakatani, Naoki; Li, Zhendong; White, Steven R.

    2016-07-01

    Current descriptions of the ab initio density matrix renormalization group (DMRG) algorithm use two superficially different languages: an older language of the renormalization group and renormalized operators, and a more recent language of matrix product states and matrix product operators. The same algorithm can appear dramatically different when written in the two different vocabularies. In this work, we carefully describe the translation between the two languages in several contexts. First, we describe how to efficiently implement the ab initio DMRG sweep using a matrix product operator based code, and the equivalence to the original renormalized operator implementation. Next we describe how to implement the general matrix product operator/matrix product state algebra within a pure renormalized operator-based DMRG code. Finally, we discuss two improvements of the ab initio DMRG sweep algorithm motivated by matrix product operator language: Hamiltonian compression, and a sum over operators representation that allows for perfect computational parallelism. The connections and correspondences described here serve to link the future developments with the past and are important in the efficient implementation of continuing advances in ab initio DMRG and related algorithms.

  18. Matrix product operators, matrix product states, and ab initio density matrix renormalization group algorithms.

    PubMed

    Chan, Garnet Kin-Lic; Keselman, Anna; Nakatani, Naoki; Li, Zhendong; White, Steven R

    2016-07-07

    Current descriptions of the ab initio density matrix renormalization group (DMRG) algorithm use two superficially different languages: an older language of the renormalization group and renormalized operators, and a more recent language of matrix product states and matrix product operators. The same algorithm can appear dramatically different when written in the two different vocabularies. In this work, we carefully describe the translation between the two languages in several contexts. First, we describe how to efficiently implement the ab initio DMRG sweep using a matrix product operator based code, and the equivalence to the original renormalized operator implementation. Next we describe how to implement the general matrix product operator/matrix product state algebra within a pure renormalized operator-based DMRG code. Finally, we discuss two improvements of the ab initio DMRG sweep algorithm motivated by matrix product operator language: Hamiltonian compression, and a sum over operators representation that allows for perfect computational parallelism. The connections and correspondences described here serve to link the future developments with the past and are important in the efficient implementation of continuing advances in ab initio DMRG and related algorithms.

  19. Research Summaries

    ERIC Educational Resources Information Center

    Brock, Stephen E., Ed.

    2011-01-01

    This article presents summaries of three articles relevant to school crisis response: (1) "Factors Contributing to Posttraumatic Growth," summarized by Steve DeBlois; (2) "Psychological Debriefing in Cross-Cultural Contexts" (Stacey Rice); and (3) "Brain Abnormalities in PTSD" (Sunny Windingstad). The first summary reports the findings of a…

  20. N=2 Minimal Conformal Field Theories and Matrix Bifactorisations of x d

    NASA Astrophysics Data System (ADS)

    Davydov, Alexei; Camacho, Ana Ros; Runkel, Ingo

    2018-01-01

    We establish an action of the representations of N = 2-superconformal symmetry on the category of matrix factorisations of the potentials x d and x d - y d , for d odd. More precisely we prove a tensor equivalence between (a) the category of Neveu-Schwarz-type representations of the N = 2 minimal super vertex operator algebra at central charge 3-6/d, and (b) a full subcategory of graded matrix factorisations of the potential x d - y d . The subcategory in (b) is given by permutation-type matrix factorisations with consecutive index sets. The physical motivation for this result is the Landau-Ginzburg/conformal field theory correspondence, where it amounts to the equivalence of a subset of defects on both sides of the correspondence. Our work builds on results by Brunner and Roggenkamp [BR], where an isomorphism of fusion rules was established.

  1. Multistationarity in mass action networks with applications to ERK activation.

    PubMed

    Conradi, Carsten; Flockerzi, Dietrich

    2012-07-01

    Ordinary Differential Equations (ODEs) are an important tool in many areas of Quantitative Biology. For many ODE systems multistationarity (i.e. the existence of at least two positive steady states) is a desired feature. In general establishing multistationarity is a difficult task as realistic biological models are large in terms of states and (unknown) parameters and in most cases poorly parameterized (because of noisy measurement data of few components, a very small number of data points and only a limited number of repetitions). For mass action networks establishing multistationarity hence is equivalent to establishing the existence of at least two positive solutions of a large polynomial system with unknown coefficients. For mass action networks with certain structural properties, expressed in terms of the stoichiometric matrix and the reaction rate-exponent matrix, we present necessary and sufficient conditions for multistationarity that take the form of linear inequality systems. Solutions of these inequality systems define pairs of steady states and parameter values. We also present a sufficient condition to identify networks where the aforementioned conditions hold. To show the applicability of our results we analyse an ODE system that is defined by the mass action network describing the extracellular signal-regulated kinase (ERK) cascade (i.e. ERK-activation).

  2. No Further Action Decision Under CERCLA, Study Area 14, Landfill No. 10, Fort Devens, Massachusetts

    DTIC Science & Technology

    1995-01-01

    I I I U.S. ArmyEnvironmentalCenter NO FURTHER ACTION DECISION UNDER 5 CERCLA * STUDY AREA 14 LANDFILL NO. 10 U FORT DEVENS , MASSACHUSETTS CONTRACT...45, 1 Feb 93 replaces THAMA Form 45 which is obsolete. U 1I NO FURTHER ACTION DECISION UNDER CERCLA STUDY AREA 14 LANDFILL NO. 10 3 FORT DEVENS ... FORT DEVENS , MASSACHUSETTS 3 TABLE OF CONTENTS Section Title Page No. EXECUTIVE SUMMARY ......................................... ES-1 I 1.0

  3. Quarterly environmental data summary for first quarter 1999

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    In support of the Weldon Spring Site Remedial Action Project Federal Facilities Agreement, a copy of the Quarterly Environmental Data Summary (QEDS) for the first quarter of 1999 is enclosed. The data presented in this constitute the QEDS. The data, except for air monitoring data and site KPA generated data (uranium analyses), were received from the contract laboratories, verified by the Weldon Spring Site verification group and merged into the database during the first quarter of 1999. KPA results for on-site total uranium analyses performed during first quarter 1999 are included. Air monitoring data presented are the most recent completemore » sets of quarterly data.« less

  4. Basin characteristics, history of stream gaging, and statistical summary of selected streamflow records for the Rapid Creek basin, western South Dakota

    USGS Publications Warehouse

    Driscoll, Daniel G.; Zogorski, John S.

    1990-01-01

    The report presents a summary of basin characteristics affecting streamflow, a history of the U.S. Geological Survey 's stream-gaging program, and a compilation of discharge records and statistical summaries for selected sites within the Rapid Creek basin. It is the first in a series which will investigate surface-water/groundwater relations along Rapid Creek. The summary of basin characteristics includes descriptions of the geology and hydrogeology, physiography and climate, land use and vegetation, reservoirs, and water use within the basin. A recounting of the U.S. Geological Survey 's stream-gaging program and a tabulation of historic stream-gaging stations within the basin are furnished. A compilation of monthly and annual mean discharge values for nine currently operated, long-term, continuous-record, streamflow-gaging stations on Rapid Creek is presented. The statistical summary for each site includes summary statistics on monthly and annual mean values, correlation matrix for monthly values, serial correlation for 1 year lag for monthly values, percentile rankings for monthly and annual mean values, low and high value tables, duration curves, and peak-discharge tables. Records of monthend contents for two reservoirs within the basin also are presented. (USGS)

  5. 76 FR 39991 - Introduction to the Unified Agenda of Federal Regulatory and Deregulatory Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... Deregulatory Actions. SUMMARY: The Regulatory Flexibility Act requires that agencies publish semiannual... agencies have chosen to publish their regulatory agendas as part of the Unified Agenda. Editions of the... Published? III. How Is the Unified Agenda Organized? IV. What Information Appears for Each Entry? V...

  6. Striatal Cholinergic Interneurons Modulate Spike-Timing in Striosomes and Matrix by an Amphetamine-Sensitive Mechanism

    PubMed Central

    Crittenden, Jill R.; Lacey, Carolyn J.; Weng, Feng-Ju; Garrison, Catherine E.; Gibson, Daniel J.; Lin, Yingxi; Graybiel, Ann M.

    2017-01-01

    The striatum is key for action-selection and the motivation to move. Dopamine and acetylcholine release sites are enriched in the striatum and are cross-regulated, possibly to achieve optimal behavior. Drugs of abuse, which promote abnormally high dopamine release, disrupt normal action-selection and drive restricted, repetitive behaviors (stereotypies). Stereotypies occur in a variety of disorders including obsessive-compulsive disorder, autism, schizophrenia and Huntington's disease, as well as in addictive states. The severity of drug-induced stereotypy is correlated with induction of c-Fos expression in striosomes, a striatal compartment that is related to the limbic system and that directly projects to dopamine-producing neurons of the substantia nigra. These characteristics of striosomes contrast with the properties of the extra-striosomal matrix, which has strong sensorimotor and associative circuit inputs and outputs. Disruption of acetylcholine signaling in the striatum blocks the striosome-predominant c-Fos expression pattern induced by drugs of abuse and alters drug-induced stereotypy. The activity of striatal cholinergic interneurons is associated with behaviors related to sensory cues, and cortical inputs to striosomes can bias action-selection in the face of conflicting cues. The neurons and neuropil of striosomes and matrix neurons have observably separate distributions, both at the input level in the striatum and at the output level in the substantia nigra. Notably, cholinergic axons readily cross compartment borders, providing a potential route for local cross-compartment communication to maintain a balance between striosomal and matrix activity. We show here, by slice electrophysiology in transgenic mice, that repetitive evoked firing patterns in striosomal and matrix striatal projection neurons (SPNs) are interrupted by optogenetic activation of cholinergic interneurons either by the addition or the deletion of spikes. We demonstrate that this

  7. Performance during internal medicine residency training and subsequent disciplinary action by state licensing boards.

    PubMed

    Papadakis, Maxine A; Arnold, Gerald K; Blank, Linda L; Holmboe, Eric S; Lipner, Rebecca S

    2008-06-03

    Physicians who are disciplined by state licensing boards are more likely to have demonstrated unprofessional behavior in medical school. Information is limited on whether similar performance measures taken during residency can predict performance as practicing physicians. To determine whether performance measures during residency predict the likelihood of future disciplinary actions against practicing internists. Retrospective cohort study. State licensing board disciplinary actions against physicians from 1990 to 2006. 66,171 physicians who entered internal medicine residency training in the United States from 1990 to 2000 and became diplomates. Predictor variables included components of the Residents' Annual Evaluation Summary ratings and American Board of Internal Medicine (ABIM) certification examination scores. 2 performance measures independently predicted disciplinary action. A low professionalism rating on the Residents' Annual Evaluation Summary predicted increased risk for disciplinary action (hazard ratio, 1.7 [95% CI, 1.3 to 2.2]), and high performance on the ABIM certification examination predicted decreased risk for disciplinary action (hazard ratio, 0.7 [CI, 0.60 to 0.70] for American or Canadian medical school graduates and 0.9 [CI, 0.80 to 1.0] for international medical school graduates). Progressively better professionalism ratings and ABIM certification examination scores were associated with less risk for subsequent disciplinary actions; the risk ranged from 4.0% for the lowest professionalism rating to 0.5% for the highest and from 2.5% for the lowest examination scores to 0.0% for the highest. The study was retrospective. Some diplomates may have practiced outside of the United States. Nondiplomates were excluded. Poor performance on behavioral and cognitive measures during residency are associated with greater risk for state licensing board actions against practicing physicians at every point on a performance continuum. These findings support

  8. Improved Use of Small Reference Panels for Conditional and Joint Analysis with GWAS Summary Statistics.

    PubMed

    Deng, Yangqing; Pan, Wei

    2018-06-01

    Due to issues of practicality and confidentiality of genomic data sharing on a large scale, typically only meta- or mega-analyzed genome-wide association study (GWAS) summary data, not individual-level data, are publicly available. Reanalyses of such GWAS summary data for a wide range of applications have become more and more common and useful, which often require the use of an external reference panel with individual-level genotypic data to infer linkage disequilibrium (LD) among genetic variants. However, with a small sample size in only hundreds, as for the most popular 1000 Genomes Project European sample, estimation errors for LD are not negligible, leading to often dramatically increased numbers of false positives in subsequent analyses of GWAS summary data. To alleviate the problem in the context of association testing for a group of SNPs, we propose an alternative estimator of the covariance matrix with an idea similar to multiple imputation. We use numerical examples based on both simulated and real data to demonstrate the severe problem with the use of the 1000 Genomes Project reference panels, and the improved performance of our new approach. Copyright © 2018 by the Genetics Society of America.

  9. Modelling Dowel Action of Discrete Reinforcing Bars in Cracked Concrete Structures

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kwan, A. K. H.; Ng, P. L.; Lam, J. Y. K.

    2010-05-21

    Dowel action is one of the component actions for shear force transfer in cracked reinforced concrete. In finite element analysis of concrete structures, the use of discrete representation of reinforcing bars is considered advantageous over the smeared representation due to the relative ease of modelling the bond-slip behaviour. However, there is very limited research on how to simulate the dowel action of discrete reinforcing bars. Herein, a numerical model for dowel action of discrete reinforcing bars crossing cracks in concrete is developed. The model features the derivation of dowel stiffness matrix based on beam-on-elastic-foundation theory and the direct assemblage ofmore » dowel stiffness into the concrete element stiffness matrices. The dowel action model is incorporated in a nonlinear finite element programme with secant stiffness formulation. Deep beams tested in the literature are analysed and it is found that the incorporation of dowel action model improves the accuracy of analysis.« less

  10. Ceramic matrix composite article and process of fabricating a ceramic matrix composite article

    DOEpatents

    Cairo, Ronald Robert; DiMascio, Paul Stephen; Parolini, Jason Robert

    2016-01-12

    A ceramic matrix composite article and a process of fabricating a ceramic matrix composite are disclosed. The ceramic matrix composite article includes a matrix distribution pattern formed by a manifold and ceramic matrix composite plies laid up on the matrix distribution pattern, includes the manifold, or a combination thereof. The manifold includes one or more matrix distribution channels operably connected to a delivery interface, the delivery interface configured for providing matrix material to one or more of the ceramic matrix composite plies. The process includes providing the manifold, forming the matrix distribution pattern by transporting the matrix material through the manifold, and contacting the ceramic matrix composite plies with the matrix material.

  11. Quality of medication information in discharge summaries from hospitals: an audit of electronic patient records.

    PubMed

    Garcia, Beate Hennie; Djønne, Berit Svendsen; Skjold, Frode; Mellingen, Ellen Marie; Aag, Trine Iversen

    2017-12-01

    Background Low quality of medication information in discharge summaries from hospitals may jeopardize optimal therapy and put the patient at risk for medication errors and adverse drug events. Objective To audit the quality of medication information in discharge summaries and explore factors associated with the quality. Setting Helgelandssykehuset Mo i Rana, a rural hospital in central Norway. Method For each month in 2013, we randomly selected 60 discharge summaries from the Department of Medicine and Surgery (totally 720) and evaluated the medication information using eight Norwegian quality criteria. Main outcome measure Mean score per discharge summary ranging from 0 (lowest quality) to 16 (highest quality). Results Mean score per discharge summary was 7.4 (SD 2.8; range 0-14), significantly higher when evaluating medications used regularly compared to mediations used as needed (7.80 vs. 6.52; p < 0.001). Lowest score was achieved for quality criteria concerning generic names, indications for medication use, reasons why changes had been made and information about the source for information. Factors associated with increased quality scores are increasing numbers of medications and male patients. Increasing age seemed to be associated with a reduced score, while type of department was not associated with the quality. Conclusion In discharge summaries from 2013, we identified a low quality of medication information in accordance with the Norwegian quality criteria. Actions for improvement are necessary and follow-up studies to monitor quality are needed.

  12. Design and synthetic considerations of matrix metalloproteinase inhibitors.

    PubMed

    Skotnicki, J S; Zask, A; Nelson, F C; Albright, J D; Levin, J I

    1999-06-30

    Experimental evidence confirms that the matrix metalloproteinases (MMPs) play a fundamental role in a wide variety of pathologic conditions that involve connective tissue destruction including osteoarthritis and rheumatoid arthritis, tumor metastasis and angiogenesis, corneal ulceration, multiple sclerosis, periodontal disease, and atherosclerosis. Modulation of MMP regulation is possible at several biochemical sites, but direct inhibition of enzyme action provides a particularly attractive target for therapeutic intervention. Hypotheses concerning inhibition of specific MMP(s) with respect to disease target and/or side-effect profile have emerged. Examples are presented of recent advances in medicinal chemistry approaches to the design of matrix metalloproteinase inhibitors (MMPIs), approaches that address structural requirements and that influence potency, selectivity, and bioavailability. Two important approaches to the design, synthesis, and biological evaluation of MMPIs are highlighted: (1) the invention of alternatives to hydroxamic acid zinc chelators and (2) the construction of nonpeptide scaffolds. One current example in each of these two approaches from our own work is described.

  13. Federal government information handbook: formerly utilized sites remedial action program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the Federal Government. It contains a summary of the organizationmore » and responsibilities of agencies within the executive branch of the Federal government which may be relevant to FUSRAP activities; a brief summary of relevant Federal statutes and regulations; a description of the structure of the US Congress, identification of the officers, relevant committees and committee chairmen; a description of the Federal legislative process; a summary of legislation enacted and considered in the recently-adjourned 96th Congress; a description of the Federal budgetary process; a summary of the Carter Administration's comprehensive radioactive waste management program; and excerpts from the text of relevant federal statutes and regulations.« less

  14. Roles and regulation of the matrix metalloproteinase system in parturition.

    PubMed

    Geng, Junnan; Huang, Cong; Jiang, Siwen

    2016-04-01

    Significant tissue destruction, repair, and remodeling are involved in parturition, which involves fetal membrane rupture, cervical ripening, and uterine contraction and its subsequent involution. Extracellular matrix degradation and remodeling by proteolytic enzymes, such as matrix metalloproteinases (MMPs), are required for the final steps of parturition. MMPs participate in physiological degradation and remodeling through their proteolytic activities on specific substrates, and are balanced by the action of their inhibitors. Disruption to this balance can result in pathological stress that ends with preterm or post-term birth or pre-eclampsia. In this review, we examine the roles and regulation of the MMP system in physiological and pathological labor, and propose a model that illustrates the mechanisms by which the MMP system contributes to these processes. © 2016 Wiley Periodicals, Inc.

  15. 78 FR 9028 - Notice of Availability of a Swine Brucellosis and Pseudorabies Proposed Action Plan

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-07

    ... DEPARTMENT OF AGRICULTURE Animal and Plant Health Inspection Service [Docket No. APHIS-2010-0086... Plant Health Inspection Service, USDA. ACTION: Notice of availability and request for comments. SUMMARY... been eliminated from commercial swine herds within the United States, but potential sources of...

  16. Matrix management in hospitals: testing theories of matrix structure and development.

    PubMed

    Burns, L R

    1989-09-01

    A study of 315 hospitals with matrix management programs was used to test several hypotheses concerning matrix management advanced by earlier theorists. The study verifies that matrix management involves several distinctive elements that can be scaled to form increasingly complex types of lateral coordinative devices. The scalability of these elements is evident only cross-sectionally. The results show that matrix complexity is not an outcome of program age, nor does matrix complexity at the time of implementation appear to influence program survival. Matrix complexity, finally, is not determined by the organization's task diversity and uncertainty. The results suggest several modifications in prevailing theories of matrix organization.

  17. Multi-jet Merging with NLO Matrix Elements

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Siegert, Frank; /Freiburg U.; Hoche, Stefan

    2011-08-18

    In the algorithm presented here, the ME+PS approach to merge samples of tree-level matrix elements into inclusive event samples is combined with the POWHEG method, which includes exact next-to-leading order matrix elements in the parton shower. The advantages of the method are discussed and the quality of its implementation in SHERPA is exemplified by results for e{sup +}e{sup -} annihilation into hadrons at LEP, for deep-inelastic lepton-nucleon scattering at HERA, for Drell-Yan lepton-pair production at the Tevatron and for W{sup +}W{sup -}-production at LHC energies. The simulation of hard QCD radiation in parton-shower Monte Carlos has seen tremendous progress overmore » the last years. It was largely stimulated by the need for more precise predictions at LHC energies where the large available phase space allows additional hard QCD radiation alongside known Standard Model processes or even signals from new physics. Two types of algorithms have been developed, which allow to improve upon the soft-collinear approximations made in the parton shower, such that hard radiation is simulated according to exact matrix elements. In the ME+PS approach [1] higher-order tree-level matrix elements for different final-state jet multiplicity are merged with each other and with subsequent parton shower emissions to generate an inclusive sample. Such a prescription is invaluable for analyses which are sensitive to final states with a large jet multiplicity. The only remaining deficiency of such tree-level calculations is the large uncertainty stemming from scale variations. The POWHEG method [2] solves this problem for the lowest multiplicity subprocess by combining full NLO matrix elements with the parton shower. While this leads to NLO accuracy in the inclusive cross section and the exact radiation pattern for the first emission, it fails to describe higher-order emissions with improved accuracy. Thus it is not sufficient if final states with high jet multiplicities are

  18. The 30/20 GHz flight experiment system, phase 2. Volume 1: Executive summary

    NASA Technical Reports Server (NTRS)

    Bronstein, L.; Kawamoto, Y.; Ribarich, J. J.; Scope, J. R.; Forman, B. J.; Bergman, S. G.; Reisenfeld, S.

    1981-01-01

    Summary information on the final communication system design, communication payload, space vehicle, and development plan for the 30/20 GHz flight experiment will be installed on the LEASAT spacecraft which will be placed into orbit from the space shuttle cargo bay. The communication concept has two parts: a truck service and a customer premise service (CPS). The trucking system serves four spot beams which are interconnected in a satellite switched time division multiple access mode by an IF switch matrix. The CPS covers two large areas of the eastern United States with a pair of scanning beams.

  19. BASIC Matrix Operations.

    ERIC Educational Resources Information Center

    Digital Equipment Corp., Maynard, MA.

    The curriculum materials and computer programs in this booklet introduce the idea of a matrix. They go on to discuss matrix operations of addition, subtraction, multiplication by a scalar, and matrix multiplication. The last section covers several contemporary applications of matrix multiplication, including problems of communication…

  20. Neuronal differentiation modulates the dystrophin Dp71d binding to the nuclear matrix

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rodriguez-Munoz, Rafael; Villarreal-Silva, Marcela; Gonzalez-Ramirez, Ricardo

    The function of dystrophin Dp71 in neuronal cells remains unknown. To approach this issue, we have selected the PC12 neuronal cell line. These cells express both a Dp71f cytoplasmic variant and a Dp71d nuclear isoform. In this study, we demonstrated by electron and confocal microscopy analyses of in situ nuclear matrices and Western blotting evaluation of cell extracts that Dp71d associates with the nuclear matrix. Interestingly, this binding is modulated during NGF-induced neuronal differentiation of PC12 cells with a twofold increment in the differentiated cells, compared to control cells. Also, distribution of Dp71d along the periphery of the nuclear matrixmore » observed in the undifferentiated cells is replaced by intense fluorescent foci localized in Center of the nucleoskeletal structure. In summary, we revealed that Dp71d is a dynamic component of nuclear matrix that might participate in the nuclear modeling occurring during neuronal differentiation.« less

  1. Corrective Action Investigation Plan for Corrective Action Unit 486: Double Tracks RADSAFE Ares, Nellis Air Force Range, Nevada, Rev. 0; DOE/NV--523 UPDATED WITH ROTC No.1 and 2

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    ITLV

    This CAIP presents a plan to investigate the DTRSA where unregulated disposal of radioactive and possibly hazardous waste occurred during decontamination activities for the Double Tracks test. The purpose of the corrective action investigation described in this CAIP is to: Identify and verify the locations of the decontamination facility and animal burial pit within the DTRSA; Identify the presence and nature of COPCs; Determine the vertical and lateral extent of COPCs; and Provide sufficient information and data to develop and evaluate appropriate corrective actions for the CAS. This CAIP was developed using the U.S. Environmental Protection Agency (EPA) Data Qualitymore » Objectives (DQOs) (EPA, 1994d) process to clearly define the goals for collecting environmental data, to determine data uses, and to design a data collection program that will satisfy these uses. A DQO scoping meeting was held prior to preparation of this plan; a brief summary of the DQOs is presented in Section 3.4. A more detailed summary of the DQO process and results is included in Appendix A.« less

  2. Ceramic matrix and resin matrix composites: A comparison

    NASA Technical Reports Server (NTRS)

    Hurwitz, Frances I.

    1987-01-01

    The underlying theory of continuous fiber reinforcement of ceramic matrix and resin matrix composites, their fabrication, microstructure, physical and mechanical properties are contrasted. The growing use of organometallic polymers as precursors to ceramic matrices is discussed as a means of providing low temperature processing capability without the fiber degradation encountered with more conventional ceramic processing techniques. Examples of ceramic matrix composites derived from particulate-filled, high char yield polymers and silsesquioxane precursors are provided.

  3. Ceramic matrix and resin matrix composites - A comparison

    NASA Technical Reports Server (NTRS)

    Hurwitz, Frances I.

    1987-01-01

    The underlying theory of continuous fiber reinforcement of ceramic matrix and resin matrix composites, their fabrication, microstructure, physical and mechanical properties are contrasted. The growing use of organometallic polymers as precursors to ceramic matrices is discussed as a means of providing low temperature processing capability without the fiber degradation encountered with more conventional ceramic processing techniques. Examples of ceramic matrix composites derived from particulate-filled, high char yield polymers and silsesquioxane precursors are provided.

  4. Matrix tablets for sustained release of repaglinide: Preparation, pharmacokinetics and hypoglycemic activity in beagle dogs.

    PubMed

    He, Wei; Wu, Mengmeng; Huang, Shiqing; Yin, Lifang

    2015-01-15

    Repaglinide (RG) is an efficient antihyperglycemic drug; however, due to its short half-life, patients are required to take the marketed products several times a day, which compromises the therapeutic effects. The present study was conducted to develop a hydrophilic sustained release matrix tablet for RG with the aims of prolonging its action time, reducing the required administration times and side effects and improving patient adherence. The matrix tablets were fabricated by a direct compression method, the optimized formulation for which was obtained by screening the factors that affected the drug release. Moreover, studies of the pharmacokinetics and hypoglycemic activity as measured by glucose assay kits were performed in dogs. Sustained drug releases profiles over 10h and a reduced influence of medium pHs on release were achieved with the optimized formulation; moreover, the in vivo performance of extended release formulation was also examined, and better absorption, a one-fold decrease in Cmax, a two-fold increase of Tmax and a prolonged hypoglycemic effect compared to the marketed product were observed. In conclusion, sustained RG release and prolonged action were observed with present matrix tablets, which therefore provide a promising formulation for T2D patients who require long-term treatment. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. High-Throughput Screening of Vascular Endothelium-Destructive or Protective Microenvironments: Cooperative Actions of Extracellular Matrix Composition, Stiffness, and Structure.

    PubMed

    Ding, Yonghui; Floren, Michael; Tan, Wei

    2017-06-01

    Pathological modification of the subendothelial extracellular matrix (ECM) has closely been associated with endothelial activation and subsequent cardiovascular disease progression. To understand regulatory mechanisms of these matrix modifications, the majority of previous efforts have focused on the modulation of either chemical composition or matrix stiffness on 2D smooth surfaces without simultaneously probing their cooperative effects on endothelium function on in vivo like 3D fibrous matrices. To this end, a high-throughput, combinatorial microarray platform on 2D and 3D hydrogel settings to resemble the compositions, stiffness, and structure of healthy and diseased subendothelial ECM has been established, and further their respective and combined effects on endothelial attachment, proliferation, inflammation, and junctional integrity have been investigated. For the first time, the results demonstrate that 3D fibrous structure resembling native ECM is a critical endothelium-protective microenvironmental factor by maintaining the stable, quiescent endothelium with strong resistance to proinflammatory stimuli. It is also revealed that matrix stiffening, in concert with chemical compositions resembling diseased ECM, particularly collagen III, could aggravate activation of nuclear factor kappa B, disruption of endothelium integrity, and susceptibility to proinflammatory stimuli. This study elucidates cooperative effects of various microenvironmental factors on endothelial activation and sheds light on new in vitro model for cardiovascular diseases. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. NASA Information Summaries.

    ERIC Educational Resources Information Center

    Mar, May 1987, 1988

    1988-01-01

    This document consists of 11 "NASA Information Summaries" grouped together: (1) "Our Planets at a Glance" (PMS-010); (2) "Space Shuttle Mission Summary: 1985-1986" (PMS-005); (3) "Astronaut Selection and Training" (PMS-019); (4) "Space Station" (PMS-008); (5) "Materials Processing in…

  7. Tree-level S-matrix of Pohlmeyer reduced form of AdS 5 × S 5 superstring theory

    NASA Astrophysics Data System (ADS)

    Hoare, B.; Tseytlin, A. A.

    2010-02-01

    With a motivation to find a 2-d Lorentz-invariant solution of the AdS 5 × S 5 superstring we continue the study of the Pohlmeyer-reduced form of this theory. The reduced theory is constructed from currents of the superstring sigma model and is classically equivalent to it. Its action is that of G/ H = Sp(2, 2) × Sp(4)/[SU(2)]4 gauged WZW model deformed by an integrable potential and coupled to fermions. This theory is UV finite and is conjectured to be related to the superstring theory also at the quantum level. Expanded near the trivial vacuum it has the same elementary excitations (8+8 massive bosonic and fermionic 2-d degrees of freedom) as the AdS 5 × S 5 superstring in the S 5 light-cone gauge or near plane-wave expansion. In contrast to the superstring case, the interaction terms in the reduced action are manifestly 2-d Lorentz invariant. Since the theory is integrable, its S-matrix should be effectively determined by the two-particle scattering. Here we explicitly compute the tree-level two-particle S-matrix for the elementary excitations of the reduced theory. We find that this S-matrix has the same index structure and group factorization properties as the superstring S-matrix computed in hep-th/0611169 but has simpler coefficients, depending only on the difference of two rapidities. While the gauge-fixed form of the reduced action has only the bosonic [SU(2)]4 part of the PSU(2|2) × PSU(2|2) symmetry of the light-cone superstring spectrum as its manifest symmetry we conjecture that it should also have a hidden fermionic symmetry that effectively interchanges bosons and fermions and which should guide us towards understanding the relation between the two S-matrices.

  8. 33 CFR 20.901 - Summary decisions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Summary decisions. 20.901 Section....901 Summary decisions. (a) Any party may move for a summary decision in all or any part of the... after service of a motion for summary decision, may serve opposing affidavits or countermove for summary...

  9. Hybrid matrix fiber composites

    DOEpatents

    Deteresa, Steven J.; Lyon, Richard E.; Groves, Scott E.

    2003-07-15

    Hybrid matrix fiber composites having enhanced compressive performance as well as enhanced stiffness, toughness and durability suitable for compression-critical applications. The methods for producing the fiber composites using matrix hybridization. The hybrid matrix fiber composites include two chemically or physically bonded matrix materials, whereas the first matrix materials are used to impregnate multi-filament fibers formed into ribbons and the second matrix material is placed around and between the fiber ribbons that are impregnated with the first matrix material and both matrix materials are cured and solidified.

  10. Executive summary: Weldon Spring Site Environmental Report for calendar year 1992. Weldon Spring Site Remedial Action Project, Weldon Spring, Missouri

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1993-06-01

    This report has been prepared to provide information about the public safety and environmental protection programs conducted by the Weldon Spring Site Remedial Action Project. The Weldon Spring site is located in southern St. Charles County, Missouri, approximately 48 km (30 mi) west of St. Louis. The site consists of two main areas, the Weldon Spring Chemical Plant and raffinate pits and the Weldon Spring Quarry. The objectives of the Site Environmental Report are to present a summary of data from the environmental monitoring program, to characterize trends and environmental conditions at the site, and to confirm compliance with environmentalmore » and health protection standards and requirements. The report also presents the status of remedial activities and the results of monitoring these activities to assess their impacts on the public and environment. The scope of the environmental monitoring program at the Weldon Spring site has changed since it was initiated. Previously, the program focused on investigations of the extent and level of contaminants in the groundwater, surface waters, buildings, and air at the site. In 1992, the level of remedial activities required monitoring for potential impacts of those activities, particularly on surface water runoff and airborne effluents. This report includes monitoring data from routine radiological and nonradiological sampling activities. These data include estimates of dose to the public from the Weldon Spring site; estimates of effluent releases; and trends in groundwater contaminant levels. Also, applicable compliance requirements, quality assurance programs, and special studies conducted in 1992 to support environmental protection programs are reviewed.« less

  11. Biofilm Matrix Proteins.

    PubMed

    Fong, Jiunn N C; Yildiz, Fitnat H

    2015-04-01

    Proteinaceous components of the biofilm matrix include secreted extracellular proteins, cell surface adhesins, and protein subunits of cell appendages such as flagella and pili. Biofilm matrix proteins play diverse roles in biofilm formation and dissolution. They are involved in attaching cells to surfaces, stabilizing the biofilm matrix via interactions with exopolysaccharide and nucleic acid components, developing three-dimensional biofilm architectures, and dissolving biofilm matrix via enzymatic degradation of polysaccharides, proteins, and nucleic acids. In this article, we will review functions of matrix proteins in a selected set of microorganisms, studies of the matrix proteomes of Vibrio cholerae and Pseudomonas aeruginosa, and roles of outer membrane vesicles and of nucleoid-binding proteins in biofilm formation.

  12. 75 FR 81874 - Action To Ensure Authority To Issue Permits Under the Prevention of Significant Deterioration...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ... Greenhouse Gas Emissions: Finding of Failure To Submit State Implementation Plan Revisions Required for Greenhouse Gases AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: The EPA is... Deterioration (PSD) requirements to greenhouse gas (GHG)-emitting sources. By notice dated December 13, 2010...

  13. Diversification of U.S. medical schools via affirmative action implementation

    PubMed Central

    Lakhan, Shaheen Emmanuel

    2003-01-01

    Background The diversification of medical school student and faculty bodies via race-conscious affirmative action policy is a societal and legal option for the U.S. Supreme Court has recently ruled its use constitutional. This paper investigates the implications of affirmative action, particularly race-conscious compared to race-blind admissions policy; explains how alternative programs are generally impractical; and provides a brief review of the history and legality of affirmative action in the United States. Discussion Selection based solely on academic qualifications such as GPA and MCAT scores does not achieve racial and ethnic diversity in medical school, nor does it adequately predict success as practicing physicians. However, race-conscious preference yields greater practice in underserved and often minority populations, furthers our biomedical research progression, augments health care for minority patients, and fosters an exceptional medical school environment where students are better able to serve an increasingly multicultural society. Summary The implementation of race-conscious affirmative action results in diversity in medicine. Such diversity has shown increased medical practice in underserved areas, thereby providing better health care for the American people. PMID:13678423

  14. 78 FR 277 - Food and Drug Administration Actions Related to Nicotine Replacement Therapies and Smoking...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-03

    ... Dependence; Public Hearing; Extension of Comment Period AGENCY: Food and Drug Administration, HHS. ACTION: Notification of public hearing; Extension of comment period. SUMMARY: The Food and Drug Administration (FDA) is... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 15 [Docket No...

  15. 76 FR 77301 - Notice of Final Federal Agency Actions on Proposed Highway Project in Wisconsin

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-12

    ...: Notice of Limitation on Claims for Judicial Review of Actions by FHWA and Other Federal Agencies. SUMMARY... Road on Midvale Boulevard to Summit Road. Stage 1 is currently scheduled for construction from... for construction from approximately 2017 to 2018. Stage 3 will be constructed when operations and...

  16. Fibronectin-tethered graphene oxide as an artificial matrix for osteogenesis.

    PubMed

    Subbiah, Ramesh; Du, Ping; Van, Se Young; Suhaeri, Muhammad; Hwang, Mintai P; Lee, Kangwon; Park, Kwideok

    2014-10-20

    An artificial matrix (Fn-Tigra), consisting of graphene oxide (GO) and fibronectin (Fn), is developed on pure titanium (Ti) substrates via an electrodropping technique assisted with a custom-made coaxial needle. The morphology and topography of the resulting artificial matrix is orderly aligned and composed of porous microcavities. In addition, Fn is homogenously distributed and firmly bound onto GO as determined via immunofluorescence and elemental mapping, respectively. The artificial matrix is moderately hydrophobic (63.7°), and exhibits an average roughness of 546 nm and a Young's modulus (E) of approximately 4.8 GPa. The biocompatibility, cellular behavior, and osteogenic potential of preosteoblasts on Fn-Tigra are compared to those of cells cultured on Ti and Ti-GO (Tigra). Cell proliferation and viability are significantly higher on Fn-Tigra and Tigra than that of cells grown on Ti. Focal adhesion molecule (vinculin) expression is highly activated at the central and peripheral area of preosteoblasts when cultured on Fn-Tigra. Furthermore, we demonstrate enhanced in vitro osteogenic differentiation of preosteoblasts cultured on Fn-Tigra over those cultured on bare Ti, as determined via Alizarin red and von Kossa staining, and the analysis of osteocalcin, type I collagen, alkaline phosphatase activity, and calcium contents. Finally, we investigate the biophysical and biomechanical properties of the cells using AFM. While the height and roughness of preosteoblasts increased with time, cell surface area decreased during in vitro osteogenesis over 2 weeks. In addition, the E of cells cultured on Tigra and Fn-Tigra increase in a statistically significant and time-dependent manner by 30%, while those cultured on bare Ti retain a relatively consistent E. In summary, we engineer a biocompatible artificial matrix (Fn-Tigra) capable of osteogenic induction and consequently demonstrate its potential in bone tissue engineering applications.

  17. Fiscal Year 2013 Trails Management Program Mitigation Action Plan Annual Report, October 2013

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pava, Daniel S.

    This Trails Management Program Mitigation Action Plan Annual Report (Trails MAPAR) has been prepared for the Department of Energy (DOE)/National Nuclear Security Administration (NNSA) as part of implementing the 2003 Final Environmental Assessment for the Proposed Los Alamos National Laboratory Trails Management Program (DOE 2003). The Trails Mitigation Action Plan (MAP) is now a part of the Site-Wide Environmental Impact Statement for the Continued Operation of Los Alamos National Laboratory (DOE/EIS 0380) Mitigation Action Plan (2008 SWEIS MAP) (DOE 2008). The MAP provides guidance for the continued implementation of the Trails Management Program at Los Alamos National Laboratory (LANL) andmore » integration of future mitigation actions into the 2008 SWEIS MAP to decrease impacts associated with recreational trails use at LANL. This eighth MAPAR includes a summary of Trails Management Program activities and actions during Fiscal Year (FY) 2013, from October 2012 through September 2013.« less

  18. Extracellular Matrix-Mediated Maturation of Human Pluripotent Stem Cell-Derived Cardiac Monolayer Structure and Electrophysiological Function.

    PubMed

    Herron, Todd J; Rocha, Andre Monteiro Da; Campbell, Katherine F; Ponce-Balbuena, Daniela; Willis, B Cicero; Guerrero-Serna, Guadalupe; Liu, Qinghua; Klos, Matt; Musa, Hassan; Zarzoso, Manuel; Bizy, Alexandra; Furness, Jamie; Anumonwo, Justus; Mironov, Sergey; Jalife, José

    2016-04-01

    Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) monolayers generated to date display an immature embryonic-like functional and structural phenotype that limits their utility for research and cardiac regeneration. In particular, the electrophysiological function of hPSC-CM monolayers and bioengineered constructs used to date are characterized by slow electric impulse propagation velocity and immature action potential profiles. Here, we have identified an optimal extracellular matrix for significant electrophysiological and structural maturation of hPSC-CM monolayers. hPSC-CM plated in the optimal extracellular matrix combination have impulse propagation velocities ≈2× faster than previously reported (43.6±7.0 cm/s; n=9) and have mature cardiomyocyte action potential profiles, including hyperpolarized diastolic potential and rapid action potential upstroke velocity (146.5±17.7 V/s; n=5 monolayers). In addition, the optimal extracellular matrix promoted hypertrophic growth of cardiomyocytes and the expression of key mature sarcolemmal (SCN5A, Kir2.1, and connexin43) and myofilament markers (cardiac troponin I). The maturation process reported here relies on activation of integrin signaling pathways: neutralization of β1 integrin receptors via blocking antibodies and pharmacological blockade of focal adhesion kinase activation prevented structural maturation. Maturation of human stem cell-derived cardiomyocyte monolayers is achieved in a 1-week period by plating cardiomyocytes on PDMS (polydimethylsiloxane) coverslips rather than on conventional 2-dimensional cell culture formats, such as glass coverslips or plastic dishes. Activation of integrin signaling and focal adhesion kinase is essential for significant maturation of human cardiac monolayers. © 2016 American Heart Association, Inc.

  19. Fundamental Studies of Low Velocity Impact Resistance of Graphite Fiber Reinforced Polymer Matrix Composites. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Bowles, K. J.

    1985-01-01

    A study was conducted to relate the impact resistance of graphite fiber reinforced composites with matrix properties through gaining an understanding of the basic mechanics involved in the deformation and fracture process, and the effect of the polymer matrix structure on these mechanisms. It was found that the resin matrix structure influences the composite impact resistance in at least two ways. The integration of flexibilizers into the polymer chain structure tends to reduce the T sub g and the mechanical properties of the polymer. The reduction in the mechanical properties of the matrix does not enhance the composite impact resistance because it allows matrix controlled failure to initiate impact damage. It was found that when the instrumented dropweight impact tester is used as a means for assessing resin toughness, the resin toughness is enhanced by the ability of the clamped specimen to deflect enough to produce sufficient membrane action to support a significant amount of the load. The results of this study indicate that crossplied composite impact resistance is very much dependent on the matrix mechanical properties.

  20. Matrix diffusion coefficients in volcanic rocks at the Nevada test site: influence of matrix porosity, matrix permeability, and fracture coating minerals.

    PubMed

    Reimus, Paul W; Callahan, Timothy J; Ware, S Doug; Haga, Marc J; Counce, Dale A

    2007-08-15

    Diffusion cell experiments were conducted to measure nonsorbing solute matrix diffusion coefficients in forty-seven different volcanic rock matrix samples from eight different locations (with multiple depth intervals represented at several locations) at the Nevada Test Site. The solutes used in the experiments included bromide, iodide, pentafluorobenzoate (PFBA), and tritiated water ((3)HHO). The porosity and saturated permeability of most of the diffusion cell samples were measured to evaluate the correlation of these two variables with tracer matrix diffusion coefficients divided by the free-water diffusion coefficient (D(m)/D*). To investigate the influence of fracture coating minerals on matrix diffusion, ten of the diffusion cells represented paired samples from the same depth interval in which one sample contained a fracture surface with mineral coatings and the other sample consisted of only pure matrix. The log of (D(m)/D*) was found to be positively correlated with both the matrix porosity and the log of matrix permeability. A multiple linear regression analysis indicated that both parameters contributed significantly to the regression at the 95% confidence level. However, the log of the matrix diffusion coefficient was more highly-correlated with the log of matrix permeability than with matrix porosity, which suggests that matrix diffusion coefficients, like matrix permeabilities, have a greater dependence on the interconnectedness of matrix porosity than on the matrix porosity itself. The regression equation for the volcanic rocks was found to provide satisfactory predictions of log(D(m)/D*) for other types of rocks with similar ranges of matrix porosity and permeability as the volcanic rocks, but it did a poorer job predicting log(D(m)/D*) for rocks with lower porosities and/or permeabilities. The presence of mineral coatings on fracture walls did not appear to have a significant effect on matrix diffusion in the ten paired diffusion cell experiments.

  1. Matrix diffusion coefficients in volcanic rocks at the Nevada test site: Influence of matrix porosity, matrix permeability, and fracture coating minerals

    NASA Astrophysics Data System (ADS)

    Reimus, Paul W.; Callahan, Timothy J.; Ware, S. Doug; Haga, Marc J.; Counce, Dale A.

    2007-08-01

    Diffusion cell experiments were conducted to measure nonsorbing solute matrix diffusion coefficients in forty-seven different volcanic rock matrix samples from eight different locations (with multiple depth intervals represented at several locations) at the Nevada Test Site. The solutes used in the experiments included bromide, iodide, pentafluorobenzoate (PFBA), and tritiated water ( 3HHO). The porosity and saturated permeability of most of the diffusion cell samples were measured to evaluate the correlation of these two variables with tracer matrix diffusion coefficients divided by the free-water diffusion coefficient ( Dm/ D*). To investigate the influence of fracture coating minerals on matrix diffusion, ten of the diffusion cells represented paired samples from the same depth interval in which one sample contained a fracture surface with mineral coatings and the other sample consisted of only pure matrix. The log of ( Dm/ D*) was found to be positively correlated with both the matrix porosity and the log of matrix permeability. A multiple linear regression analysis indicated that both parameters contributed significantly to the regression at the 95% confidence level. However, the log of the matrix diffusion coefficient was more highly-correlated with the log of matrix permeability than with matrix porosity, which suggests that matrix diffusion coefficients, like matrix permeabilities, have a greater dependence on the interconnectedness of matrix porosity than on the matrix porosity itself. The regression equation for the volcanic rocks was found to provide satisfactory predictions of log( Dm/ D*) for other types of rocks with similar ranges of matrix porosity and permeability as the volcanic rocks, but it did a poorer job predicting log( Dm/ D*) for rocks with lower porosities and/or permeabilities. The presence of mineral coatings on fracture walls did not appear to have a significant effect on matrix diffusion in the ten paired diffusion cell experiments.

  2. Brief announcement: Hypergraph parititioning for parallel sparse matrix-matrix multiplication

    DOE PAGES

    Ballard, Grey; Druinsky, Alex; Knight, Nicholas; ...

    2015-01-01

    The performance of parallel algorithms for sparse matrix-matrix multiplication is typically determined by the amount of interprocessor communication performed, which in turn depends on the nonzero structure of the input matrices. In this paper, we characterize the communication cost of a sparse matrix-matrix multiplication algorithm in terms of the size of a cut of an associated hypergraph that encodes the computation for a given input nonzero structure. Obtaining an optimal algorithm corresponds to solving a hypergraph partitioning problem. Furthermore, our hypergraph model generalizes several existing models for sparse matrix-vector multiplication, and we can leverage hypergraph partitioners developed for that computationmore » to improve application-specific algorithms for multiplying sparse matrices.« less

  3. Nanocrystal doped matrixes

    DOEpatents

    Parce, J. Wallace; Bernatis, Paul; Dubrow, Robert; Freeman, William P.; Gamoras, Joel; Kan, Shihai; Meisel, Andreas; Qian, Baixin; Whiteford, Jeffery A.; Ziebarth, Jonathan

    2010-01-12

    Matrixes doped with semiconductor nanocrystals are provided. In certain embodiments, the semiconductor nanocrystals have a size and composition such that they absorb or emit light at particular wavelengths. The nanocrystals can comprise ligands that allow for mixing with various matrix materials, including polymers, such that a minimal portion of light is scattered by the matrixes. The matrixes of the present invention can also be utilized in refractive index matching applications. In other embodiments, semiconductor nanocrystals are embedded within matrixes to form a nanocrystal density gradient, thereby creating an effective refractive index gradient. The matrixes of the present invention can also be used as filters and antireflective coatings on optical devices and as down-converting layers. Processes for producing matrixes comprising semiconductor nanocrystals are also provided. Nanostructures having high quantum efficiency, small size, and/or a narrow size distribution are also described, as are methods of producing indium phosphide nanostructures and core-shell nanostructures with Group II-VI shells.

  4. Orexin Regulates Bone Remodeling via a Dominant Positive Central Action and a Subordinate Negative Peripheral Action

    PubMed Central

    Wei, Wei; Motoike, Toshiyuki; Krzeszinski, Jing Y.; Jin, Zixue; Xie, Xian-Jin; Dechow, Paul C.; Yanagisawa, Masashi; Wan, Yihong

    2014-01-01

    SUMMARY Orexin neuropeptides promote arousal, appetite, reward, and energy expenditure. However, whether orexin affects bone mass accrual is unknown. Here we show that orexin functions centrally through orexin receptor 2 (OX2R) in the brain to enhance bone formation. OX2R-null mice exhibit low-bone-mass owing to elevated circulating leptin; whereas central administration of an OX2R-selective agonist augments bone mass. Conversely, orexin also functions peripherally through orexin receptor 1 (OX1R) in the bone to suppress bone formation. OX1R-null mice exhibit high-bone-mass owing to a mesenchymal stem cell differentiation shift from adipocyte to osteoblast that results from higher osseous ghrelin expression. The central action is dominant over the peripheral action because bone mass is reduced in orexin-null and OX1R2R-double-null mice but enhanced in orexin over-expressing transgenic mice. These findings reveal orexin as a critical rheostat of skeletal homeostasis that exerts a yin-yang dual regulation, and highlight orexin as a therapeutic target for osteoporosis. PMID:24794976

  5. NFSMI Research Summary

    ERIC Educational Resources Information Center

    Nettles, Mary Frances

    2014-01-01

    The NFSMI Research Summary is a continuing series of summaries reporting recently completed research and research-based resources funded by the National Food Service Management Institute. The following research studies are summarized in this article: (1) Succession Planning for Management Level Staff in School Nutrition Programs; (2)…

  6. Summary Writing: A Topographical Study.

    ERIC Educational Resources Information Center

    Sherrard, Carol

    1986-01-01

    Examines summaries of expository text written by undergraduate students to discover the nature of text-to-summary mapping. Finds that simple omission and one-to-one mapping of text sentences into summary sentences were the most favored strategies. (FL)

  7. Cytotoxic T Lymphocyte Trafficking and Survival in an Augmented Fibrin Matrix Carrier

    PubMed Central

    Zou, Zhaoxia; Denny, Erin; Brown, Christine E.; Jensen, Michael C.; Li, Gang; Fujii, Tatsuhiro; Neman, Josh; Jandial, Rahul; Chen, Mike

    2012-01-01

    Cell-based therapies have intriguing potential for the treatment of a variety of neurological disorders. One such example is genetically engineered cytotoxic T lymphocytes (CTLs) that are being investigated in brain tumor clinical trials. The development of methods for CTL delivery is critical to their use in the laboratory and clinical setting. In our study, we determined whether CTLs can migrate through fibrin matrices and if their migration, survival, and function could be modulated by adding chemokines to the matrix. Our results indicated that CTLs can freely migrate through fibrin matrices. As expected, the addition of the monocyte chemotactic protein-1 (MCP-1), also known as chemokine C-C motif ligand 2 (CCL2), to the surrounding media increased egress of the CTLs out of the fibrin clot. Interleukin (IL) -2 and/or IL-15 embedded in the matrix enhanced T cell survival and further promoted T cell migration. The interleukin-13 receptor alpha 2 specific (IL-13R alpha2) T cells that traveled out of the fibrin clot retained the capacity to kill U251 glioma cells. In summary, CTLs can survive and migrate robustly in fibrin matrices. These processes can be influenced by modification of matrix constituents. We conclude that fibrin matrices may be suitable T cell carriers and can be used to facilitate understanding of T cell interaction with the surrounding microenvironment. PMID:22496835

  8. Cytotoxic T lymphocyte trafficking and survival in an augmented fibrin matrix carrier.

    PubMed

    Zou, Zhaoxia; Denny, Erin; Brown, Christine E; Jensen, Michael C; Li, Gang; Fujii, Tatsuhiro; Neman, Josh; Jandial, Rahul; Chen, Mike

    2012-01-01

    Cell-based therapies have intriguing potential for the treatment of a variety of neurological disorders. One such example is genetically engineered cytotoxic T lymphocytes (CTLs) that are being investigated in brain tumor clinical trials. The development of methods for CTL delivery is critical to their use in the laboratory and clinical setting. In our study, we determined whether CTLs can migrate through fibrin matrices and if their migration, survival, and function could be modulated by adding chemokines to the matrix. Our results indicated that CTLs can freely migrate through fibrin matrices. As expected, the addition of the monocyte chemotactic protein-1 (MCP-1), also known as chemokine C-C motif ligand 2 (CCL2), to the surrounding media increased egress of the CTLs out of the fibrin clot. Interleukin (IL) -2 and/or IL-15 embedded in the matrix enhanced T cell survival and further promoted T cell migration. The interleukin-13 receptor alpha 2 specific (IL-13R alpha2) T cells that traveled out of the fibrin clot retained the capacity to kill U251 glioma cells. In summary, CTLs can survive and migrate robustly in fibrin matrices. These processes can be influenced by modification of matrix constituents. We conclude that fibrin matrices may be suitable T cell carriers and can be used to facilitate understanding of T cell interaction with the surrounding microenvironment.

  9. 15 CFR 904.210 - Summary decision.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Summary decision. 904.210 Section 904... Hearing and Appeal Procedures General § 904.210 Summary decision. The Judge may render a summary decision... summary decision as a matter of law. ...

  10. Report Summary--Rio Political Declaration on Social Determinants of Health: A Snapshot of Canadian Actions 2015.

    PubMed

    Stankiewicz, A; Herel, M; DesMeules, M

    2015-09-01

    In 2012, Canada and other United Nations (UN) Member States endorsed the "Rio Political Declaration on Social Determinants of Health" (Rio Declaration), a non-binding pledge which calls on World Health Organization (WHO) Member States to improve/influence the working and living conditions that affect health and well-being. The Rio Declaration sets out actions to address health inequities in five themes: to adopt better governance for health and development; to promote participation in policy making and implementation; to further reorient the health sector towards reducing health inequities; to strengthen global governance and collaboration; and to monitor and increase accountability. In 2013, following the endorsement of the Rio Declaration, the Government of Canada released a report to begin to document Canadian actions related to its five themes. Building on this first report, and in anticipation of WHO reporting on Member State implementation of the Rio Declaration at the May 2015 World Health Assembly, the Government of Canada developed the report, Rio Political Declaration on Social Determinants of Health: A Snapshot of Canadian Actions 2015, which showcases Canada's recent actions since 2013 contributing to the advancement of the five Rio Declaration themes. The report provides a current picture of the diverse spectrum of activities undertaken across levels of government and sectors to advance health equity and address social determinants of health in Canada, and intends to stimulate global and domestic exchange and uptake of promising practices to advance health equity.

  11. Panel 2.17: private commercial sector partnerships for health action in crises.

    PubMed

    Sundnes, Knut Ole; Sannerkvist, Milan; Hedger, Philip; Woodworth, Brent; Hyre, Anne; Cuddyre, Terrence; Waldman, Ronald

    2005-01-01

    This is a summary of the presentations and discussion of Panel 2.17, Private Commercial Sector Partnerships for Health Action in Crises of the Conference, Health Aspects of the Tsunami Disaster in Asia, convened by the World Health Organization (WHO) in Phuket, Thailand, 04-06 May 2005. The topics discussed included issues related to private sector partnerships for health action in crises as pertain to the responses to the damage created by the Tsunami. It is presented in the following sections: (1) key questions; (2) issues and challenges; (3) lessons learned; (4) what was done well?; (5) what could have been done better?; and (6) conclusions and recommendations.

  12. The matrix peptide exporter HAF-1 signals a mitochondrial unfolded protein response by activating the transcription factor ZC376.7 in C. elegans

    PubMed Central

    Haynes, Cole M.; Yang, Yun; Blais, Steven P.; Neubert, Thomas A.; Ron, David

    2010-01-01

    Summary Genetic analyses previously implicated the matrix-localized protease ClpP in signaling the stress of protein misfolding in the mitochondrial matrix to activate nuclear encoded mitochondrial chaperone genes in C. elegans (UPRmt). Here we report that haf-1, a gene encoding a mitochondria-localized ATP-binding cassette protein, is required for signaling within the UPRmt and for coping with misfolded protein stress. Peptide efflux from isolated mitochondria was ATP-dependent and required HAF-1 and the protease ClpP. Defective UPRmt signaling in the haf-1 deleted worms was associated with failure of the bZIP protein, ZC376.7, to localize to nuclei in worms with perturbed mitochondrial protein folding, whereas zc376.7(RNAi) strongly inhibited the UPRmt. These observations suggest a simple model whereby perturbation of the protein-folding environment in the mitochondrial matrix promotes ClpP-mediated generation of peptides whose haf-1-dependent export from the matrix contributes to UPRmt signaling across the mitochondrial inner membrane. PMID:20188671

  13. 31 CFR 26.3 - Availability of Environmental Impact Assessment Summaries (EIA Summaries) and Environmental...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Availability of Environmental Impact Assessment Summaries (EIA Summaries) and Environmental Impact Assessments (EIAs). 26.3 Section 26.3 Money and...) 466-8191, not a toll-free call). (ii) If a copy of an EIA Summary is not available from the BIC...

  14. 31 CFR 26.3 - Availability of Environmental Impact Assessment Summaries (EIA Summaries) and Environmental...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Availability of Environmental Impact Assessment Summaries (EIA Summaries) and Environmental Impact Assessments (EIAs). 26.3 Section 26.3 Money and...) 466-8191, not a toll-free call). (ii) If a copy of an EIA Summary is not available from the BIC...

  15. 31 CFR 26.3 - Availability of Environmental Impact Assessment Summaries (EIA Summaries) and Environmental...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Availability of Environmental Impact Assessment Summaries (EIA Summaries) and Environmental Impact Assessments (EIAs). 26.3 Section 26.3 Money and...) 466-8191, not a toll-free call). (ii) If a copy of an EIA Summary is not available from the BIC...

  16. 31 CFR 26.3 - Availability of Environmental Impact Assessment Summaries (EIA Summaries) and Environmental...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Availability of Environmental Impact Assessment Summaries (EIA Summaries) and Environmental Impact Assessments (EIAs). 26.3 Section 26.3 Money and...) 466-8191, not a toll-free call). (ii) If a copy of an EIA Summary is not available from the BIC...

  17. 31 CFR 26.3 - Availability of Environmental Impact Assessment Summaries (EIA Summaries) and Environmental...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Availability of Environmental Impact Assessment Summaries (EIA Summaries) and Environmental Impact Assessments (EIAs). 26.3 Section 26.3 Money and...) 466-8191, not a toll-free call). (ii) If a copy of an EIA Summary is not available from the BIC...

  18. 40 CFR 1502.12 - Summary.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Summary. 1502.12 Section 1502.12 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY ENVIRONMENTAL IMPACT STATEMENT § 1502.12 Summary. Each environmental impact statement shall contain a summary which adequately and accurately summarizes...

  19. Dermis, acellular dermal matrix, and fibroblasts from different layers of pig skin exhibit different profibrotic characteristics: evidence from in vivo study

    PubMed Central

    Zuo, Yanhai; Lu, Shuliang

    2017-01-01

    To explore the profibrotic characteristics of the autografted dermis, acellular dermal matrix, and dermal fibroblasts from superficial/deep layers of pig skin, 93 wounds were established on the dorsa of 7 pigs. 72 wounds autografted with the superficial/deep dermis and acellular dermal matrix served as the superficial/deep dermis and acellular dermal matrix group, respectively, and were sampled at 2, 4, and 8 weeks post-wounding. 21 wounds autografted with/without superficial/deep dermal fibroblasts served as the superficial/deep dermal fibroblast group and the control group, respectively, and were sampled at 2 weeks post-wounding. The hematoxylin and eosin staining showed that the wounded skin thicknesses in the deep dermis group (superficial acellular dermal matrix group) were significantly greater than those in the superficial dermis group (deep acellular dermal matrix group) at each time point, the thickness of the cutting plane in the deep dermal fibroblast group was significantly greater than that in the superficial dermal fibroblast group and the control group. The western blots showed that the α-smooth muscle actin expression in the deep dermis group (superficial acellular dermal matrix group) was significantly greater than that in the superficial dermis group (deep acellular dermal matrix group) at each time point. In summary, the deep dermis and dermal fibroblasts exhibited more profibrotic characteristics than the superficial ones, on the contrary, the deep acellular dermal matrix exhibited less profibrotic characteristics than the superficial one. PMID:28423561

  20. 17 CFR 12.207 - Summary disposition.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Summary disposition. 12.207... REPARATIONS Rules Applicable to Summary Decisional Proceedings § 12.207 Summary disposition. (a) Filing of... proceeding may file a motion for summary disposition at any time until the parties have concluded their...

  1. Matrix Interdiction Problem

    NASA Astrophysics Data System (ADS)

    Kasiviswanathan, Shiva Prasad; Pan, Feng

    In the matrix interdiction problem, a real-valued matrix and an integer k is given. The objective is to remove a set of k matrix columns that minimizes in the residual matrix the sum of the row values, where the value of a row is defined to be the largest entry in that row. This combinatorial problem is closely related to bipartite network interdiction problem that can be applied to minimize the probability that an adversary can successfully smuggle weapons. After introducing the matrix interdiction problem, we study the computational complexity of this problem. We show that the matrix interdiction problem is NP-hard and that there exists a constant γ such that it is even NP-hard to approximate this problem within an n γ additive factor. We also present an algorithm for this problem that achieves an (n - k) multiplicative approximation ratio.

  2. 49 CFR 194.113 - Information summary.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Information summary. 194.113 Section 194.113... Response Plans § 194.113 Information summary. (a) The information summary for the core plan, required by... state(s). (b) The information summary for the response zone appendix, required in § 194.107, must...

  3. Similar Cerebral Motor Plans for Real and Virtual Actions

    PubMed Central

    Bozzacchi, Chiara; Giusti, Maria Assunta; Pitzalis, Sabrina; Spinelli, Donatella; Di Russo, Francesco

    2012-01-01

    A simple movement, such as pressing a button, can acquire different meanings by producing different consequences, such as starting an elevator or switching a TV channel. We evaluated whether the brain activity preceding a simple action is modulated by the expected consequences of the action itself. To further this aim, the motor-related cortical potentials were compared during two key-press actions that were identical from the kinematics point of view but different in both meaning and consequences. In one case (virtual grasp), the key-press started a video clip showing a hand moving toward a cup and grasping it; in the other case, the key-press did not produce any consequence (key-press). A third condition (real grasp) was also compared, in which subjects actually grasped the cup, producing the same action presented in the video clip. Data were collected from fifteen subjects. The results showed that motor preparation for virtual grasp (starting 3 s before the movement onset) was different from that of the key-press and similar to the real grasp preparation–as if subjects had to grasp the cup in person. In particular, both virtual and real grasp presented a posterior parietal negativity preceding activity in motor and pre-motor areas. In summary, this finding supports the hypothesis that motor preparation is affected by the meaning of the action, even when the action is only virtual. PMID:23112847

  4. A Comparative Summary on Antioxidant-like Actions of Timolol with Other Antioxidants in Diabetic Cardiomyopathy.

    PubMed

    Turan, Belma

    2016-01-01

    Cellular signaling associated with cardiac β-adrenergic receptors (β-AR) is composed of coupled mechanism among β 1-/β2-AR and Gs proteins with contribution of constitutive β3-AR coupling to Gi proteins. However, down-regulation of β-ARs in the heart under pathological conditions is mediated with a signaling G proteins-included mechanism. Additionally, there are serious conflicting data on this field in literature yet. Although some of these conflictions are generally related with either experimental protocols for different approaches or different animal models. To treat cardiovascular disorders, generally, various types of β-blockers are used while their action mechanisms are not fully known yet. Furthermore, although β-blockers are generally used to block the activated β-ARs, they can be used to scavenge free radicals under oxidative stress. Studies, in whole-system, organ or cellular levels, showed that some β-blockers, including timolol, have protective-actions against increased oxidative stress in diseased heart via ROSscavenging. Additionally, it has been mentioned that some β-blockers nicely prevented the development of heart failure in both experimental and clinical studies by restoring sarcoplasmic reticulum (SR) Ca(2+) release channels, RyR2. Since diabetic cardiomyopathy is recognized due to its diminished responsiveness to β1-AR agonist stimulation in the heart with an up-regulation of β 3-AR, inducing a strong negative inotropic effect on left ventricular function, it has been shown that treatment of streptozotocin-diabetic rats with timolol provided a marked cardio-protection. Importantly, it has been also documented that timolol treatment-dependent cardio-protection in diabetic rats includes basically prevention of RyR2- hyperphosphorylation, which, in turn, block Ca(2+)-leakage from SR via scavenging oxidative agents to control redox-state of cardiomyocytes. This action of timolol in diabetic heart is very similar to other known

  5. SYMBMAT: Symbolic computation of quantum transition matrix elements

    NASA Astrophysics Data System (ADS)

    Ciappina, M. F.; Kirchner, T.

    2012-08-01

    We have developed a set of Mathematica notebooks to compute symbolically quantum transition matrices relevant for atomic ionization processes. The utilization of a symbolic language allows us to obtain analytical expressions for the transition matrix elements required in charged-particle and laser induced ionization of atoms. Additionally, by using a few simple commands, it is possible to export these symbolic expressions to standard programming languages, such as Fortran or C, for the subsequent computation of differential cross sections or other observables. One of the main drawbacks in the calculation of transition matrices is the tedious algebraic work required when initial states other than the simple hydrogenic 1s state need to be considered. Using these notebooks the work is dramatically reduced and it is possible to generate exact expressions for a large set of bound states. We present explicit examples of atomic collisions (in First Born Approximation and Distorted Wave Theory) and laser-matter interactions (within the Dipole and Strong Field Approximations and different gauges) using both hydrogenic wavefunctions and Slater-Type Orbitals with arbitrary nlm quantum numbers as initial states. Catalogue identifier: AEMI_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEMI_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC license, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 71 628 No. of bytes in distributed program, including test data, etc.: 444 195 Distribution format: tar.gz Programming language: Mathematica Computer: Single machines using Linux or Windows (with cores with any clock speed, cache memory and bits in a word) Operating system: Any OS that supports Mathematica. The notebooks have been tested under Windows and Linux and with versions 6.x, 7.x and 8.x Classification: 2.6 Nature of problem

  6. Dissociable intrinsic functional networks support noun-object and verb-action processing.

    PubMed

    Yang, Huichao; Lin, Qixiang; Han, Zaizhu; Li, Hongyu; Song, Luping; Chen, Lingjuan; He, Yong; Bi, Yanchao

    2017-12-01

    The processing mechanism of verbs-actions and nouns-objects is a central topic of language research, with robust evidence for behavioral dissociation. The neural basis for these two major word and/or conceptual classes, however, remains controversial. Two experiments were conducted to study this question from the network perspective. Experiment 1 found that nodes of the same class, obtained through task-evoked brain imaging meta-analyses, were more strongly connected with each other than nodes of different classes during resting-state, forming segregated network modules. Experiment 2 examined the behavioral relevance of these intrinsic networks using data from 88 brain-damaged patients, finding that across patients the relative strength of functional connectivity of the two networks significantly correlated with the noun-object vs. verb-action relative behavioral performances. In summary, we found that verbs-actions and nouns-objects are supported by separable intrinsic functional networks and that the integrity of such networks accounts for the relative noun-object- and verb-action-selective deficits. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. Implementation research design: integrating participatory action research into randomized controlled trials

    PubMed Central

    Leykum, Luci K; Pugh, Jacqueline A; Lanham, Holly J; Harmon, Joel; McDaniel, Reuben R

    2009-01-01

    Background A gap continues to exist between what is known to be effective and what is actually delivered in the usual course of medical care. The goal of implementation research is to reduce this gap. However, a tension exists between the need to obtain generalizeable knowledge through implementation trials, and the inherent differences between healthcare organizations that make standard interventional approaches less likely to succeed. The purpose of this paper is to explore the integration of participatory action research and randomized controlled trial (RCT) study designs to suggest a new approach for studying interventions in healthcare settings. Discussion We summarize key elements of participatory action research, with particular attention to its collaborative, reflective approach. Elements of participatory action research and RCT study designs are discussed and contrasted, with a complex adaptive systems approach used to frame their integration. Summary The integration of participatory action research and RCT design results in a new approach that reflects not only the complex nature of healthcare organizations, but also the need to obtain generalizeable knowledge regarding the implementation process. PMID:19852784

  8. Effectiveness of metal matrix and ceramic matrix composites as orbital debris shield materials

    NASA Technical Reports Server (NTRS)

    Mcgill, Preston B.; Mount, Angela R.

    1992-01-01

    The effectiveness of two metal matrix composites and one ceramic matrix material in defeating hypervelocity impacts at about 3.8 km/s are evaluated to determine the potential of these composites as spacecraft shield materials. The metal matrix composites investigated consist of SiC particles (70 percent by volume) in an aluminum matrix and Al2O3 particles (50 percent by volume) in an Al matrix. The ceramic composite consists of ZrB2 platelets in a ZrC matrix. Both the metal matrix and ceramic matrix composites are found to perform as well or better than 6061-T6 aluminum, which is presently used in the Whipple type bumper shield of Space Station Freedom. Test results indicate that the composites tested may have applications as micrometeoroid/orbital debris shield materials.

  9. 78 FR 40169 - Notice of Realty Action: Classification for Lease and Subsequent Conveyance for Recreation and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ...; 13-08807; MO 4500050498; TAS: 14X5232] Notice of Realty Action: Classification for Lease and.... SUMMARY: The Bureau of Land Management (BLM) has examined and found suitable for classification for lease... parties may submit written comments regarding the proposed classification of the land, or lease and/or...

  10. 13 CFR 134.408 - Summary decision.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Summary decision. 134.408 Section... § 134.408 Summary decision. (a) Generally. In any appeal under this subpart D, either party may move or cross-move for summary decision, as provided in § 134.212. (b) Summary decision based on fewer than all...

  11. Summary travel characteristics : Hawaii

    DOT National Transportation Integrated Search

    1997-10-01

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  12. Summary travel characteristics : Massachusetts

    DOT National Transportation Integrated Search

    1997-09-29

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  13. Summary travel characteristics : Arkansas

    DOT National Transportation Integrated Search

    1997-09-29

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  14. Summary travel characteristics : Virgina

    DOT National Transportation Integrated Search

    1997-09-30

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  15. Summary travel characteristics : Florida

    DOT National Transportation Integrated Search

    1997-09-29

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  16. Summary travel characteristics : Kansas

    DOT National Transportation Integrated Search

    1997-09-29

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  17. Summary travel characteristics : California

    DOT National Transportation Integrated Search

    1997-09-29

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  18. Summary travel characteristics : Texas

    DOT National Transportation Integrated Search

    1997-09-30

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  19. Summary travel characteristics : Illinois

    DOT National Transportation Integrated Search

    1997-09-29

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  20. Summary travel characteristics : Montana

    DOT National Transportation Integrated Search

    1997-09-30

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  1. Summary travel characteristics : Kentucky

    DOT National Transportation Integrated Search

    1997-09-29

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  2. Summary travel characteristics : Wisconsin

    DOT National Transportation Integrated Search

    1997-10-01

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  3. Summary travel characteristics : Maryland

    DOT National Transportation Integrated Search

    1997-09-19

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  4. Summary travel characteristics : Nevada

    DOT National Transportation Integrated Search

    1997-09-30

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  5. Summary travel characteristics : Iowa

    DOT National Transportation Integrated Search

    1997-09-29

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  6. Summary travel characteristics : Washington

    DOT National Transportation Integrated Search

    1997-10-01

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  7. Summary travel characteristics : Alabama

    DOT National Transportation Integrated Search

    1997-09-29

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  8. Summary travel characteristics : Nebraska

    DOT National Transportation Integrated Search

    1997-09-30

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  9. Summary travel characteristics : Oregon

    DOT National Transportation Integrated Search

    1997-10-01

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  10. Summary travel characteristics : Maine

    DOT National Transportation Integrated Search

    1997-09-29

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  11. Summary travel characteristics : Utah

    DOT National Transportation Integrated Search

    1997-09-30

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  12. Summary travel characteristics : Michigan

    DOT National Transportation Integrated Search

    1997-09-29

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  13. Summary travel characteristics : Missouri

    DOT National Transportation Integrated Search

    1997-09-30

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  14. Summary travel characteristics : Colorado

    DOT National Transportation Integrated Search

    1997-09-29

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  15. Summary travel characteristics : Alaska

    DOT National Transportation Integrated Search

    1997-09-29

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  16. Summary travel characteristics : Oklahoma

    DOT National Transportation Integrated Search

    1997-09-30

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  17. Summary travel characteristics : Indiana

    DOT National Transportation Integrated Search

    1997-09-29

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  18. Summary travel characteristics : Idaho

    DOT National Transportation Integrated Search

    1997-09-29

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  19. Summary travel characteristics : Tennessee

    DOT National Transportation Integrated Search

    1997-09-30

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  20. Summary travel characteristics : Georgia

    DOT National Transportation Integrated Search

    1997-09-29

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  1. Summary travel characteristics : Delaware

    DOT National Transportation Integrated Search

    1997-09-29

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  2. Summary travel characteristics : Ohio

    DOT National Transportation Integrated Search

    1997-09-30

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  3. Summary travel characteristics : Arizona

    DOT National Transportation Integrated Search

    1997-09-29

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  4. Summary travel characteristics : Wyoming

    DOT National Transportation Integrated Search

    1997-01-01

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  5. Summary travel characteristics : Minnesota

    DOT National Transportation Integrated Search

    1997-09-30

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  6. Summary travel characteristics : Vermont

    DOT National Transportation Integrated Search

    1997-09-30

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  7. Summary travel characteristics : Louisiana

    DOT National Transportation Integrated Search

    1997-09-29

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  8. Summary travel characteristics : Mississippi

    DOT National Transportation Integrated Search

    1997-09-30

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  9. Summary travel characteristics : Connecticut

    DOT National Transportation Integrated Search

    1997-09-29

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  10. Summary travel characteristics : Pennsylvania

    DOT National Transportation Integrated Search

    1997-09-30

    The Summary Travel Characteristics publication series contains summary tables of travel statistics for census regions and divisions, States, and metropolitan areas. The tables in this report provide an overview of the findings of the American Travel ...

  11. 29 CFR 18.1006 - Summaries.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Summaries. 18.1006 Section 18.1006 Labor Office of the... ADMINISTRATIVE LAW JUDGES Rules of Evidence Contents of Writings, Recordings, and Photographs § 18.1006 Summaries... at the hearing may be presented in the form of a chart, summary, or calculation. The originals, or...

  12. 19 CFR 142.16 - Entry summary documentation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Entry summary documentation. 142.16 Section 142.16... TREASURY (CONTINUED) ENTRY PROCESS Entry Summary Documentation § 142.16 Entry summary documentation. (a) Entry summary not filed at time of entry. When the entry documentation is filed before the entry summary...

  13. Apparent mass matrix of standing subjects exposed to multi-axial whole-body vibration.

    PubMed

    Tarabini, Marco; Solbiati, Stefano; Saggin, Bortolino; Scaccabarozzi, Diego

    2016-08-01

    This paper describes the experimental characterisation of the apparent mass matrix of eight male subjects in standing position and the identification of nonlinearities under both mono-axial and dual-axis whole-body vibration. The nonlinear behaviour of the response was studied using the conditioned response techniques considering models of increasing complexity. Results showed that the cross-axis terms are comparable to the diagonal terms. The contribution of the nonlinear effects are minor and can be endorsed to the change of modal parameters during the tests. The nonlinearity generated by the vibration magnitude is more evident in the subject response, since magnitude-dependent effects in the population are overlaid by the scatter in the subjects' biometric data. The biodynamic response is influenced by the addition of a secondary vibration axis and, in case of dual-axis vibrations, the overall magnitude has a marginal contribution. Practitioner Summary: We have measured both the diagonal and cross-axis elements of the apparent mass matrix. The effect of nonlinearities and the simultaneous presence of vibration along two axes are smaller than the inter-subject variability.

  14. Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating

    PubMed Central

    Engler, Adam J.; Carag-Krieger, Christine; Johnson, Colin P.; Raab, Matthew; Tang, Hsin-Yao; Speicher, David W.; Sanger, Joseph W.; Sanger, Jean M.; Discher, Dennis E.

    2009-01-01

    Summary Fibrotic rigidification following a myocardial infarct is known to impair cardiac output, and it is also known that cardiomyocytes on rigid culture substrates show a progressive loss of rhythmic beating. Here, isolated embryonic cardiomyocytes cultured on a series of flexible substrates show that matrices that mimic the elasticity of the developing myocardial microenvironment are optimal for transmitting contractile work to the matrix and for promoting actomyosin striation and 1-Hz beating. On hard matrices that mechanically mimic a post-infarct fibrotic scar, cells overstrain themselves, lack striated myofibrils and stop beating; on very soft matrices, cells preserve contractile beating for days in culture but do very little work. Optimal matrix leads to a strain match between cell and matrix, and suggests dynamic differences in intracellular protein structures. A ‘cysteine shotgun’ method of labeling the in situ proteome reveals differences in assembly or conformation of several abundant cytoskeletal proteins, including vimentin, filamin and myosin. Combined with recent results, which show that stem cell differentiation is also highly sensitive to matrix elasticity, the methods and analyses might be useful in the culture and assessment of cardiogenesis of both embryonic stem cells and induced pluripotent stem cells. The results described here also highlight the need for greater attention to fibrosis and mechanical microenvironments in cell therapy and development. PMID:18957515

  15. Age-related collagen turnover of the interstitial matrix and basement membrane: Implications of age- and sex-dependent remodeling of the extracellular matrix.

    PubMed

    Kehlet, Stephanie N; Willumsen, Nicholas; Armbrecht, Gabriele; Dietzel, Roswitha; Brix, Susanne; Henriksen, Kim; Karsdal, Morten A

    2018-01-01

    The extracellular matrix (ECM) plays a vital role in maintaining normal tissue function. Collagens are major components of the ECM and there is a tight equilibrium between degradation and formation of these proteins ensuring tissue health and homeostasis. As a consequence of tissue turnover, small collagen fragments are released into the circulation, which act as important biomarkers in the study of certain tissue-related remodeling factors in health and disease. The aim of this study was to establish an age-related collagen turnover profile of the main collagens of the interstitial matrix (type I and III collagen) and basement membrane (type IV collagen) in healthy men and women. By using well-characterized competitive ELISA-assays, we assessed specific fragments of degraded (C1M, C3M, C4M) and formed (PINP, Pro-C3, P4NP7S) type I, III and IV collagen in serum from 617 healthy men and women ranging in ages from 22 to 86. Subjects were divided into 5-year age groups according to their sex and age. Groups were compared using Kruskal-Wallis adjusted for Dunn's multiple comparisons test and Mann-Whitney t-test. Age-specific changes in collagen turnover was most profound for type I collagen. PINP levels decreased in men with advancing age, whereas in women, the level decreased in early adulthood followed by an increase around the age of menopause (age 40-60). Sex-specific changes in type I, III and IV collagen turnover was present at the age around menopause (age 40-60) with women having an increased turnover. In summary, collagen turnover is affected by age and sex with the interstitial matrix and the basement membrane being differently regulated. The observed changes needs to be accounted for when measuring ECM related biomarkers in clinical studies.

  16. Modification of natural matrix lac-bagasse for matrix composite films

    NASA Astrophysics Data System (ADS)

    Nurhayati, Nanik Dwi; Widjaya, Karna; Triyono

    2016-02-01

    Material technology continues to be developed in order to a material that is more efficient with composite technology is a combination of two or more materials to obtain the desired material properties. The objective of this research was to modification and characterize the natural matrix lac-bagasse as composite films. The first step, natural matrix lac was changed from solid to liquid using an ethanol as a solvent so the matrix homogenly. Natural matrix lac was modified by adding citric acid with concentration variation. Secondly, the bagasse delignification using acid hydrolysis method. The composite films natural matrix lac-bagasse were prepared with optimum modified the addition citric acid 5% (v/v) and delignification bagasse optimum at 1,5% (v/v) in hot press at 80°C 6 Kg/cm-1. Thirdly, composite films without and with modification were characterized functional group analysis using FTIR spectrophotometer and mechanical properties using Universal Testing Machine. The result of research showed natural matrix lac can be modified by reaction with citric acid. FTIR spectra showed without and with modification had functional groups wide absorption 3448 cm-1 group -OH, C=O ester strong on 1712 cm-1 and the methylene group -CH2 on absorption 1465 cm-1. The mechanical properties showed tensile strength 0,55 MPa and elongation at break of 0,95 %. So that composite films natural matrix lac can be made with reinforcement bagasse for material application.

  17. Scotland's knowledge network: a progress report on Knowledge into Action.

    PubMed

    Wales, Ann; Boyle, Derek

    2015-11-01

    Launched in 2012, Knowledge into Action is the national knowledge management strategy for the health and social care workforce in Scotland. It is transforming the role of the national digital knowledge service--NHS Education for Scotlands' Knowledge Network--and the NHSS librarian role to offer more active, tailored support for translating knowledge into frontline clinical practice. This includes the development of a national evidence search and summary service, help with converting knowledge into practical and usable formats for easy use at point of care and with using digital tools to share clinicians' learning, experience and expertise. Through this practical support, Knowledge into Action is contributing to quality and safety outcomes across NHS Scotland, building clinicians' capacity and capability in applying knowledge in frontline practice and service improvement. © The Author(s) 2015.

  18. 76 FR 76981 - Request for Public Comments Concerning U.S.-Canada Action Plan for Perimeter Security and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-09

    ..., DHS. ACTION: Notice. SUMMARY: The United States and Canada are staunch allies, vital economic partners... in which the United States and Canada share responsibility for the security and resilience of our..., while working together to facilitate the flows of legitimate travel and trade. Beyond the Border...

  19. Action Plan for Children: New Jersey. Recommendations of the Governor's Committee on Children's Services Planning.

    ERIC Educational Resources Information Center

    Larson, R. Alexandra; And Others

    Focusing on problems believed to pose the greatest risk to the children of New Jersey, this report sets forth the views of the Governor's Committee on Children's Services Planning on priorities for action. After an executive summary of the report, the issues identified by the committee are summarized in chapter II, which describes the current…

  20. Modeling for Matrix Multicracking Evolution of Cross-ply Ceramic-Matrix Composites Using Energy Balance Approach

    NASA Astrophysics Data System (ADS)

    Longbiao, Li

    2015-12-01

    The matrix multicracking evolution of cross-ply ceramic-matrix composites (CMCs) has been investigated using energy balance approach. The multicracking of cross-ply CMCs was classified into five modes, i.e., (1) mode 1: transverse multicracking; (2) mode 2: transverse multicracking and matrix multicracking with perfect fiber/matrix interface bonding; (3) mode 3: transverse multicracking and matrix multicracking with fiber/matrix interface debonding; (4) mode 4: matrix multicracking with perfect fiber/matrix interface bonding; and (5) mode 5: matrix multicracking with fiber/matrix interface debonding. The stress distributions of four cracking modes, i.e., mode 1, mode 2, mode 3 and mode 5, are analysed using shear-lag model. The matrix multicracking evolution of mode 1, mode 2, mode 3 and mode 5, has been determined using energy balance approach. The effects of ply thickness and fiber volume fraction on matrix multicracking evolution of cross-ply CMCs have been investigated.

  1. Matrix superpotentials

    NASA Astrophysics Data System (ADS)

    Nikitin, Anatoly G.; Karadzhov, Yuri

    2011-07-01

    We present a collection of matrix-valued shape invariant potentials which give rise to new exactly solvable problems of SUSY quantum mechanics. It includes all irreducible matrix superpotentials of the generic form W=kQ+\\frac{1}{k} R+P, where k is a variable parameter, Q is the unit matrix multiplied by a real-valued function of independent variable x, and P and R are the Hermitian matrices depending on x. In particular, we recover the Pron'ko-Stroganov 'matrix Coulomb potential' and all known scalar shape invariant potentials of SUSY quantum mechanics. In addition, five new shape invariant potentials are presented. Three of them admit a dual shape invariance, i.e. the related Hamiltonians can be factorized using two non-equivalent superpotentials. We find discrete spectrum and eigenvectors for the corresponding Schrödinger equations and prove that these eigenvectors are normalizable.

  2. The corrosion behavior of CVI SiC matrix in SiCf/SiC composites under molten fluoride salt environment

    NASA Astrophysics Data System (ADS)

    Wang, Hongda; Feng, Qian; Wang, Zhen; Zhou, Haijun; Kan, Yanmei; Hu, Jianbao; Dong, Shaoming

    2017-04-01

    High temperature corrosion behavior and microstructural evolution of designed chemical-vapor-infiltrated SiC matrix in SiC fiber reinforced SiC ceramic matrix composites in 46.5LiF-11.5NaF-42.0KF (mol. %) eutectic salt at 800 °C for various corrosion time was studied. Worse damage was observed as extending the exposure time, with the mass loss ratio increasing from 0.716 wt. % for 50 h to 5.914 wt. % for 500 h. The mass loss rate showed a trend of first decrease and then increase with the extended corrosion exposure. Compared with the near-stoichiometric SiC matrix layers, the O-contained boundaries between deposited matrix layers and the designed Si-rich SiC matrix layers were much less corrosion resistant and preferentially corroded. Liner relationship between the mass loss ratio and the corrosion time obtained from 50 h to 300 h indicated that the corrosion action was reaction-control process. Further corrosion would lead to matrix layer exfoliation and higher mass loss ratio.

  3. Quarterly environmental data summary for first quarter 1998

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1998-05-01

    In support of the Weldon Spring Site Remedial Action Project Federal Facilities Agreement, a copy of the Quarterly Environmental Data Summary (QEDS) for the first quarter of 1998 is enclosed. The data presented in this letter and attachment constitute the QEDS. The data were received from the contract laboratories, verified by the Weldon Spring Site verification group and, except for air monitoring data and site KPA generated data (uranium analyses), merged into the data base during the first quarter of 1998. Air monitoring data presented are the most recent complete sets of quarterly data. Air data are not stored inmore » the data base, and KPA data are not merged into the regular data base. Significant data, defined as data values that have exceeded defined {open_quotes}above normal{close_quotes} Level 2 values, are discussed in this letter for Environmental Monitoring Plan (EMP) generated data only. Above normal Level 2 values are based, in ES&H procedures, on historical high values, DOE Derived Concentration Guides (DCGs), NPDES limits and other guidelines. The procedures also establish actions to be taken in the event that {open_quotes}above normal{close_quotes} data occur. All data received and verified during the first quarter were within a permissible range of variability except for those detailed below. Above normal occurrences are cited for groundwater, air, and NPDES data. There were none for springs or surface water. The following discussion offers a brief summary of the data merged during the first quarter that exceeded the above normal criteria and updates on past reported above normal data. The attached tables present the most recent data for air and the data merged into the data base during the first quarter 1998 for groundwater, NPDES, surface water, and springs. Graphs showing concentrations of selected contaminants of concern at some of the critical locations have also been included in this QEDS. The graphs are discussed in the separate

  4. Tackling action-based video abstraction of animated movies for video browsing

    NASA Astrophysics Data System (ADS)

    Ionescu, Bogdan; Ott, Laurent; Lambert, Patrick; Coquin, Didier; Pacureanu, Alexandra; Buzuloiu, Vasile

    2010-07-01

    We address the issue of producing automatic video abstracts in the context of the video indexing of animated movies. For a quick browse of a movie's visual content, we propose a storyboard-like summary, which follows the movie's events by retaining one key frame for each specific scene. To capture the shot's visual activity, we use histograms of cumulative interframe distances, and the key frames are selected according to the distribution of the histogram's modes. For a preview of the movie's exciting action parts, we propose a trailer-like video highlight, whose aim is to show only the most interesting parts of the movie. Our method is based on a relatively standard approach, i.e., highlighting action through the analysis of the movie's rhythm and visual activity information. To suit every type of movie content, including predominantly static movies or movies without exciting parts, the concept of action depends on the movie's average rhythm. The efficiency of our approach is confirmed through several end-user studies.

  5. Matrix differentiation formulas

    NASA Technical Reports Server (NTRS)

    Usikov, D. A.; Tkhabisimov, D. K.

    1983-01-01

    A compact differentiation technique (without using indexes) is developed for scalar functions that depend on complex matrix arguments which are combined by operations of complex conjugation, transposition, addition, multiplication, matrix inversion and taking the direct product. The differentiation apparatus is developed in order to simplify the solution of extremum problems of scalar functions of matrix arguments.

  6. 49 CFR 194.113 - Information summary.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Response Plans § 194.113 Information summary. (a) The information summary for the core plan, required by... include: (1) The information summary for the core plan; (2) The names or titles and 24-hour telephone...

  7. Thermal and mechanical behavior of metal matrix and ceramic matrix composites

    NASA Technical Reports Server (NTRS)

    Kennedy, John M. (Editor); Moeller, Helen H. (Editor); Johnson, W. S. (Editor)

    1990-01-01

    The present conference discusses local stresses in metal-matrix composites (MMCs) subjected to thermal and mechanical loads, the computational simulation of high-temperature MMCs' cyclic behavior, an analysis of a ceramic-matrix composite (CMC) flexure specimen, and a plasticity analysis of fibrous composite laminates under thermomechanical loads. Also discussed are a comparison of methods for determining the fiber-matrix interface frictional stresses of CMCs, the monotonic and cyclic behavior of an SiC/calcium aluminosilicate CMC, the mechanical and thermal properties of an SiC particle-reinforced Al alloy MMC, the temperature-dependent tensile and shear response of a graphite-reinforced 6061 Al-alloy MMC, the fiber/matrix interface bonding strength of MMCs, and fatigue crack growth in an Al2O3 short fiber-reinforced Al-2Mg matrix MMC.

  8. Demographic analysis from summaries of an age-structured population

    USGS Publications Warehouse

    Link, William A.; Royle, J. Andrew; Hatfield, Jeff S.

    2003-01-01

    Demographic analyses of age-structured populations typically rely on life history data for individuals, or when individual animals are not identified, on information about the numbers of individuals in each age class through time. While it is usually difficult to determine the age class of a randomly encountered individual, it is often the case that the individual can be readily and reliably assigned to one of a set of age classes. For example, it is often possible to distinguish first-year from older birds. In such cases, the population age structure can be regarded as a latent variable governed by a process prior, and the data as summaries of this latent structure. In this article, we consider the problem of uncovering the latent structure and estimating process parameters from summaries of age class information. We present a demographic analysis for the critically endangered migratory population of whooping cranes (Grus americana), based only on counts of first-year birds and of older birds. We estimate age and year-specific survival rates. We address the controversial issue of whether management action on the breeding grounds has influenced recruitment, relating recruitment rates to the number of seventh-year and older birds, and examining the pattern of variation through time in this rate.

  9. Bottom-up and top-down solid-state NMR approaches for bacterial biofilm matrix composition

    NASA Astrophysics Data System (ADS)

    Cegelski, Lynette

    2015-04-01

    The genomics and proteomics revolutions have been enormously successful in providing crucial "parts lists" for biological systems. Yet, formidable challenges exist in generating complete descriptions of how the parts function and assemble into macromolecular complexes and whole-cell assemblies. Bacterial biofilms are complex multicellular bacterial communities protected by a slime-like extracellular matrix that confers protection to environmental stress and enhances resistance to antibiotics and host defenses. As a non-crystalline, insoluble, heterogeneous assembly, the biofilm extracellular matrix poses a challenge to compositional analysis by conventional methods. In this perspective, bottom-up and top-down solid-state NMR approaches are described for defining chemical composition in complex macrosystems. The "sum-of-the-parts" bottom-up approach was introduced to examine the amyloid-integrated biofilms formed by Escherichia coli and permitted the first determination of the composition of the intact extracellular matrix from a bacterial biofilm. An alternative top-down approach was developed to define composition in Vibrio cholerae biofilms and relied on an extensive panel of NMR measurements to tease out specific carbon pools from a single sample of the intact extracellular matrix. These two approaches are widely applicable to other heterogeneous assemblies. For bacterial biofilms, quantitative parameters of matrix composition are needed to understand how biofilms are assembled, to improve the development of biofilm inhibitors, and to dissect inhibitor modes of action. Solid-state NMR approaches will also be invaluable in obtaining parameters of matrix architecture.

  10. Bottom-Up and Top-Down Solid-State NMR Approaches for Bacterial Biofilm Matrix Composition

    PubMed Central

    Cegelski, Lynette

    2015-01-01

    The genomics and proteomics revolutions have been enormously successful in providing crucial “parts lists” for biological systems. Yet, formidable challenges exist in generating complete descriptions of how the parts function and assemble into macromolecular complexes and whole-cell assemblies. Bacterial biofilms are complex multicellular bacterial communities protected by a slime-like extracellular matrix that confers protection to environmental stress and enhances resistance to antibiotics and host defenses. As a non-crystalline, insoluble, heterogeneous assembly, the biofilm extracellular matrix poses a challenge to compositional analysis by conventional methods. In this Perspective, bottom-up and top-down solid-state NMR approaches are described for defining chemical composition in complex macrosystems. The “sum-of-theparts” bottom-up approach was introduced to examine the amyloid-integrated biofilms formed by E. coli and permitted the first determination of the composition of the intact extracellular matrix from a bacterial biofilm. An alternative top-down approach was developed to define composition in V. cholerae biofilms and relied on an extensive panel of NMR measurements to tease out specific carbon pools from a single sample of the intact extracellular matrix. These two approaches are widely applicable to other heterogeneous assemblies. For bacterial biofilms, quantitative parameters of matrix composition are needed to understand how biofilms are assembled, to improve the development of biofilm inhibitors, and to dissect inhibitor modes of action. Solid-state NMR approaches will also be invaluable in obtaining parameters of matrix architecture. PMID:25797008

  11. Bottom-up and top-down solid-state NMR approaches for bacterial biofilm matrix composition.

    PubMed

    Cegelski, Lynette

    2015-04-01

    The genomics and proteomics revolutions have been enormously successful in providing crucial "parts lists" for biological systems. Yet, formidable challenges exist in generating complete descriptions of how the parts function and assemble into macromolecular complexes and whole-cell assemblies. Bacterial biofilms are complex multicellular bacterial communities protected by a slime-like extracellular matrix that confers protection to environmental stress and enhances resistance to antibiotics and host defenses. As a non-crystalline, insoluble, heterogeneous assembly, the biofilm extracellular matrix poses a challenge to compositional analysis by conventional methods. In this perspective, bottom-up and top-down solid-state NMR approaches are described for defining chemical composition in complex macrosystems. The "sum-of-the-parts" bottom-up approach was introduced to examine the amyloid-integrated biofilms formed by Escherichia coli and permitted the first determination of the composition of the intact extracellular matrix from a bacterial biofilm. An alternative top-down approach was developed to define composition in Vibrio cholerae biofilms and relied on an extensive panel of NMR measurements to tease out specific carbon pools from a single sample of the intact extracellular matrix. These two approaches are widely applicable to other heterogeneous assemblies. For bacterial biofilms, quantitative parameters of matrix composition are needed to understand how biofilms are assembled, to improve the development of biofilm inhibitors, and to dissect inhibitor modes of action. Solid-state NMR approaches will also be invaluable in obtaining parameters of matrix architecture. Copyright © 2015 Elsevier Inc. All rights reserved.

  12. The symmetries of the system matrix and propagator matrix for anisotropic media and of the system matrix forperiodically layered media

    NASA Astrophysics Data System (ADS)

    Xu, Guo-Ming; Ni, Si-Dao

    1998-11-01

    The `auxiliary' symmetry properties of the system matrix (symmetry with respect to the trailing diagonal) for a general anisotropic dissipative medium and the special form for a monoclinic medium are revealed by rearranging the motion-stress vector. The propagator matrix of a single-layer general anisotropic dissipative medium is also shown to have auxiliary symmetry. For the multilayered case, a relatively simple matrix method is utilized to obtain the inverse of the propagator matrix. Further, Woodhouse's inverse of the propagator matrix for a transversely isotropic medium is extended in a clearer form to handle the monoclinic symmetric medium. The properties of a periodic layer system are studied through its system matrix Aly , which is computed from the propagator matrix P. The matrix Aly is then compared with Aeq , the system matrix for the long-wavelength equivalent medium of the periodic isotropic layers. Then we can find how the periodic layered medium departs from its long-wavelength equivalent medium when the wavelength decreases. In our numerical example, the results show that, when λ/D decreases to 6-8, the components of the two matrices will depart from each other. The component ratio of these two matrices increases to its maximum (more than 15 in our numerical test) when λ/D is reduced to 2.3, and then oscillates with λ/D when it is further reduced. The eigenvalues of the system matrix Aly show that the velocities of P and S waves decrease when λ/D is reduced from 6-8 and reach their minimum values when λ/D is reduced to 2.3 and then oscillate afterwards. We compute the time shifts between the peaks of the transmitted waves and the incident waves. The resulting velocity curves show a similar variation to those computed from the eigenvalues of the system matrix Aly , but on a smaller scale. This can be explained by the spectrum width of the incident waves.

  13. Chondrites: The Compaction of Fine Matrix and Matrix-like Chondrule Rims

    NASA Astrophysics Data System (ADS)

    Wasson, J. T.

    1995-09-01

    Primitive chondritic meteorites mainly consist of chondrules, sulfide+/-metal, and fine-grained matrix. The most unequilibrated chondrites preserve in their phase compositions and, to a lesser degree, their textures, many details about processes that occurred in the solar nebula. On the other hand, much of the textural evidence records processes that occurred in or on the parent body. I suggest that the low-porosity of chondrule matrix and matrix-like rims reflects compaction processes that occurred in asteroid-size bodies, and that neither matrix lumps nor compact matrix-like rims on chondrules could have achieved their observed low porosities in the solar nebula. Recent theoretical studies by Donn and Meakin (1) and Chokshi et al. (2) have concluded that grain-grain sticking in the solar nebula mainly produces fluffy structures having very high porosities (probably >>50%). If these structures grow large enough, they can provide an aerogel-like matrix that can trap chondrules as well as metal and sulfide grains, and thus form suitable precursors of chondritic meteorites. However, the strength of any such structure formed in the solar nebula must be a trivial fraction of that required to survive passage through the Earth's atmosphere in order to fall as a meteorite. The best evidence of accretionary structures appears to be that reported by Metzler et al. (3). They made SEM images of entire thin sections of CM chondrites, and showed that, in the best preserved chondrites, rims are present on all entitities--on chondrules, chondrule fragments, refractory inclusions, etc. A study by Krot and Wasson (4) shows a more complex situation in ordinary chondrites. Although matrix is common, a sizable fraction of chondrules are not surrounded by matrix-like rims. As summarized by Rubin and Krot (1995), there are reports of small textural and compositional differences between matrix lumps and mean matrix-like chondrule rims, but there is so much overlap in properties between

  14. Grape seed extracts inhibit dentin matrix degradation by MMP-3

    PubMed Central

    Khaddam, Mayssam; Salmon, Benjamin; Le Denmat, Dominique; Tjaderhane, Leo; Menashi, Suzanne; Chaussain, Catherine; Rochefort, Gaël Y.; Boukpessi, Tchilalo

    2014-01-01

    Since Matrix metalloproteinases (MMPs) have been suggested to contribute to dentin caries progression, the hypothesis that MMP inhibition would affect the progression of dentin caries is clinically relevant. Grape seed extracts (GSE) have been previously reported to be natural inhibitors of MMPs. Objective: To evaluate the capacity of a GSE mouthrinse to prevent the degradation of demineralized dentin matrix by MMP-3 (stromelysin-1). Materials and Methods: Standardized blocks of dentin obtained from sound permanent teeth extracted for orthodontic reasons were demineralized with Ethylenediaminetetraacetic acid (EDTA) and pretreated either with (A) GSE (0.2% w/v), (B) amine fluoride (AmF) (20% w/v), (C) a mouthrinse which contains both, (D) placebo, (E) sodium fluoride (0.15 mg.ml−1), (F) PBS, (G) Chlorhexidine digluconate (CHX), or (H) zinc chloride (ZnCl2). The dentin blocks were then incubated with activated recombinant MMP-3. The supernatants were analyzed by Western Blot for several dentin matrix proteins known to be MMP-3 substrate. In parallel, scanning electron microscopy (SEM) was performed on resin replica of the dentin blocks. Results: Western blot analysis of the supernatants revealed that MMP-3 released from the dentin matrix small proteoglycans (decorin and biglycan) and dentin sialoprotein (DSP) in the AmF, sodium fluoride, PBS and placebo pretreated groups, but not in the GSE and mouthrinse pretreated groups. SEM examination of resin replica showed that the mouthrinse and its active components not only had an anti-MMP action but also modified the dentin surface accessibility. Conclusion: This study shows that GSE either alone or combined with AmF as in the evaluated mouthrinse limits dentin matrix degradation. This association may be promising to prevent the progression of caries within dentin. However, the procedure should be adapted to clinically relevant durations. PMID:25400590

  15. 76 FR 6816 - Notice of Realty Action: Recreation and Public Purposes Act Classification; Lease and Conveyance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-08

    ...: Notice of Realty Action. SUMMARY: The Cultural Department of the State of New Mexico has filed an... classification for lease and/or conveyance to the Cultural Department of the State of New Mexico, under the...&PP Act, the Cultural Department of the State of New Mexico filed an application for the above...

  16. Multi-threaded Sparse Matrix-Matrix Multiplication for Many-Core and GPU Architectures.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Deveci, Mehmet; Rajamanickam, Sivasankaran; Trott, Christian Robert

    Sparse Matrix-Matrix multiplication is a key kernel that has applications in several domains such as scienti c computing and graph analysis. Several algorithms have been studied in the past for this foundational kernel. In this paper, we develop parallel algorithms for sparse matrix-matrix multiplication with a focus on performance portability across different high performance computing architectures. The performance of these algorithms depend on the data structures used in them. We compare different types of accumulators in these algorithms and demonstrate the performance difference between these data structures. Furthermore, we develop a meta-algorithm, kkSpGEMM, to choose the right algorithm and datamore » structure based on the characteristics of the problem. We show performance comparisons on three architectures and demonstrate the need for the community to develop two phase sparse matrix-matrix multiplication implementations for efficient reuse of the data structures involved.« less

  17. Computational Everyday Life Human Behavior Model as Servicable Knowledge

    NASA Astrophysics Data System (ADS)

    Motomura, Yoichi; Nishida, Yoshifumi

    A project called `Open life matrix' is not only a research activity but also real problem solving as an action research. This concept is realized by large-scale data collection, probabilistic causal structure model construction and information service providing using the model. One concrete outcome of this project is childhood injury prevention activity in new team consist of hospital, government, and many varieties of researchers. The main result from the project is a general methodology to apply probabilistic causal structure models as servicable knowledge for action research. In this paper, the summary of this project and future direction to emphasize action research driven by artificial intelligence technology are discussed.

  18. Nonclassicality and Entanglement in multimode radiation fields under the action of classicality preserving devices

    NASA Astrophysics Data System (ADS)

    Chaturvedi, S.

    2011-09-01

    In this work we examine the possibilities of converting quantum optical nonclassicality into entanglement in multimode under the action of classicality preserving devices such as beamsplitters. While the single mode case is amenable to a complete analysis, non availability of certain crucial results in the classical theory of moments in the multimode situations forces us to treat these cases with lesser degree of generality by taking recourse to the familiar Mandel matrix and its extensions. We generalize the Mandel matrix from one-mode states to the two-mode situation, leading to a natural classification of states with varying levels of nonclassicality. For two-mode states we present a single test which, if successful, simultaneouly witnesses nonclassicality as well as NPT entanglement. We develop a test for NPT entanglement after beamsplitter action on a nonclassical state, designed in such a way that it remains `close' to that for nonclassicality. In the same spirit we analyse the result of three-mode `beamsplitter' action after coupling to an ancilla in the Fock ground state. The concept of genuine tripartite entanglement and scalar measures of nonclassicality at the Mandel level for two mode systems are discussed and illustrated with the help of several examples.

  19. 19 CFR 210.18 - Summary determinations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Summary determinations. 210.18 Section 210.18 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Motions § 210.18 Summary determinations. (a) Motions for summary...

  20. 19 CFR 210.18 - Summary determinations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Summary determinations. 210.18 Section 210.18 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Motions § 210.18 Summary determinations. (a) Motions for summary...

  1. 19 CFR 210.18 - Summary determinations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 3 2013-04-01 2013-04-01 false Summary determinations. 210.18 Section 210.18 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Motions § 210.18 Summary determinations. (a) Motions for summary...

  2. 19 CFR 210.18 - Summary determinations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 3 2014-04-01 2014-04-01 false Summary determinations. 210.18 Section 210.18 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Motions § 210.18 Summary determinations. (a) Motions for summary...

  3. 16 CFR 3.24 - Summary decisions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Summary decisions. 3.24 Section 3.24... PRACTICE FOR ADJUDICATIVE PROCEEDINGS Prehearing Procedures; Motions; Interlocutory Appeals; Summary Decisions § 3.24 Summary decisions. (a) Procedure. (1) Any party may move, with or without supporting...

  4. Action theory within the structural view.

    PubMed

    Rangell, L

    1989-01-01

    This paper presents a summary of a cohesive theme coursing through a group of selected papers written by the author over four decades. Purpose, intention, choice and decision are seen as firmly anchored within structural metapsychological theory. These constitute a cohesive and operative psychoanalytic theory of action, which Hartmann stated did not exist within psychoanalytic theory. The exposure and inclusion of this unconscious series of intrapsychic events obviates the need for many alternative theories which have been erected to give a place to these very functions. Unconscious decision, ego will and volition, the unconscious initiation and execution of action, operate during waking life, with as complete and complex secondary process mentation as secondary revision organizes the final shape and contents of a dream during sleep. These conceptual changes and advances have important psychosociolegal implications. Man not only does not know why he acts; he also does not always know that he acts. The mainstream itself is not monolithic and has also resisted the development of many of these advances. Factors responsible for this lag or block are adduced, which include anti-scientism or intellectuality, as well as, most importantly, a resistance to an increase of responsibility and accountability.

  5. 19 CFR 191.73 - Export summary procedure.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Export summary procedure. 191.73 Section 191.73... TREASURY (CONTINUED) DRAWBACK Exportation and Destruction § 191.73 Export summary procedure. (a) General. The export summary procedure consists of a Chronological Summary of Exports used to support a drawback...

  6. 12 CFR 908.52 - Partial summary disposition.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Partial summary disposition. 908.52 Section 908... summary disposition. If the presiding officer determines that a party is entitled to summary disposition... presiding officer has determined that summary disposition is warranted will be addressed in the recommended...

  7. Automatic switching matrix

    DOEpatents

    Schlecht, Martin F.; Kassakian, John G.; Caloggero, Anthony J.; Rhodes, Bruce; Otten, David; Rasmussen, Neil

    1982-01-01

    An automatic switching matrix that includes an apertured matrix board containing a matrix of wires that can be interconnected at each aperture. Each aperture has associated therewith a conductive pin which, when fully inserted into the associated aperture, effects electrical connection between the wires within that particular aperture. Means is provided for automatically inserting the pins in a determined pattern and for removing all the pins to permit other interconnecting patterns.

  8. Mid-infrared matrix assisted laser desorption ionization with a water/glycerol matrix

    NASA Astrophysics Data System (ADS)

    Caldwell, Kathleen L.; Murray, Kermit K.

    1998-05-01

    Matrix-assisted laser desorption ionization (MALDI) mass spectra were obtained using a water and glycerol matrix with a tunable mid-infrared optical parametric oscillator. The matrix consists of a 1:1 mixture of water and glycerol deposited on a thin layer of nitrocellulose and cooled to -30°C. When exposed to vacuum, most of the water evaporates, leaving a matrix of glycerol with residual water. The peptide bradykinin and the protein bovine insulin were used to test this new matrix. Mass spectra were obtained for bradykinin between 2.76 and 3.1 μm with the maximum analyte signal at 2.8 μm. Mass resolution in excess of 2000 for bradykinin and 500 for insulin was obtained with delayed ion extraction and a linear time of flight mass spectrometer. The addition of nitrocellulose to the matrix resulted in exceptionally durable samples: more than 10,000 laser shots which produced analyte signal could be obtained from a single sample spot.

  9. 7 CFR 3402.12 - Project summary.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Project summary. 3402.12 Section 3402.12 Agriculture... AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS PROGRAM Preparation of an Application § 3402.12 Project summary. Using the Project Summary, Form NIFA-2003, applicants must summarize...

  10. 7 CFR 3402.12 - Project summary.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Project summary. 3402.12 Section 3402.12 Agriculture... AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS PROGRAM Preparation of an Application § 3402.12 Project summary. Using the Project Summary, Form NIFA-2003, applicants must summarize...

  11. 7 CFR 3402.12 - Project summary.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Project summary. 3402.12 Section 3402.12 Agriculture... AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS PROGRAM Preparation of an Application § 3402.12 Project summary. Using the Project Summary, Form NIFA-2003, applicants must summarize...

  12. 7 CFR 3402.12 - Project summary.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Project summary. 3402.12 Section 3402.12 Agriculture... AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS PROGRAM Preparation of an Application § 3402.12 Project summary. Using the Project Summary, Form CSREES-2003, applicants must summarize...

  13. 7 CFR 3402.12 - Project summary.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Project summary. 3402.12 Section 3402.12 Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION, AND EXTENSION... FELLOWSHIP GRANTS PROGRAM Preparation of an Application § 3402.12 Project summary. Using the Project Summary...

  14. 12 CFR 509.29 - Summary disposition.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Summary disposition. 509.29 Section 509.29... PROCEDURE IN ADJUDICATORY PROCEEDINGS Uniform Rules of Practice and Procedure § 509.29 Summary disposition... granting a motion for summary disposition if the undisputed pleaded facts, admissions, affidavits...

  15. Engineering a collagen matrix that replicates the biological properties of native extracellular matrix.

    PubMed

    Nam, Kwangwoo; Sakai, Yuuki; Funamoto, Seiichi; Kimura, Tsuyoshi; Kishida, Akio

    2011-01-01

    In this study, we aimed to replicate the function of native tissues that can be used in tissue engineering and regenerative medicine. The key to such replication is the preparation of an artificial collagen matrix that possesses a structure resembling that of the extracellular matrix. We, therefore, prepared a collagen matrix by fibrillogenesis in a NaCl/Na(2)HPO(4) aqueous solution using a dialysis cassette and investigated its biological behavior in vitro and in vivo. The in vitro cell adhesion and proliferation did not show any significant differences. The degradation rate in the living body could be controlled according to the preparation condition, where the collagen matrix with high water content (F-collagen matrix, >98%) showed fast degradation and collagen matrix with lower water content (T-collagen matrix, >80%) showed no degradation for 8 weeks. The degradation did not affect the inflammatory response at all and relatively faster wound healing response was observed. Comparing this result with that of collagen gel and decellularized cornea, it can be concluded that the structural factor is very important and no cell abnormal behavior would be observed for quaternary structured collagen matrix.

  16. 5 CFR 2423.27 - Summary judgment motions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Summary judgment motions. 2423.27 Section..., Prehearing Procedures § 2423.27 Summary judgment motions. (a) Motions. Any party may move for a summary... to be determined at the hearing. (c) Decision. If all issues are decided by summary judgment, no...

  17. Carbonate fuel cell matrix

    DOEpatents

    Farooque, Mohammad; Yuh, Chao-Yi

    1996-01-01

    A carbonate fuel cell matrix comprising support particles and crack attenuator particles which are made platelet in shape to increase the resistance of the matrix to through cracking. Also disclosed is a matrix having porous crack attenuator particles and a matrix whose crack attenuator particles have a thermal coefficient of expansion which is significantly different from that of the support particles, and a method of making platelet-shaped crack attenuator particles.

  18. Matrix population models from 20 studies of perennial plant populations

    USGS Publications Warehouse

    Ellis, Martha M.; Williams, Jennifer L.; Lesica, Peter; Bell, Timothy J.; Bierzychudek, Paulette; Bowles, Marlin; Crone, Elizabeth E.; Doak, Daniel F.; Ehrlen, Johan; Ellis-Adam, Albertine; McEachern, Kathryn; Ganesan, Rengaian; Latham, Penelope; Luijten, Sheila; Kaye, Thomas N.; Knight, Tiffany M.; Menges, Eric S.; Morris, William F.; den Nijs, Hans; Oostermeijer, Gerard; Quintana-Ascencio, Pedro F.; Shelly, J. Stephen; Stanley, Amanda; Thorpe, Andrea; Tamara, Ticktin; Valverde, Teresa; Weekley, Carl W.

    2012-01-01

    Demographic transition matrices are one of the most commonly applied population models for both basic and applied ecological research. The relatively simple framework of these models and simple, easily interpretable summary statistics they produce have prompted the wide use of these models across an exceptionally broad range of taxa. Here, we provide annual transition matrices and observed stage structures/population sizes for 20 perennial plant species which have been the focal species for long-term demographic monitoring. These data were assembled as part of the "Testing Matrix Models" working group through the National Center for Ecological Analysis and Synthesis (NCEAS). In sum, these data represent 82 populations with >460 total population-years of data. It is our hope that making these data available will help promote and improve our ability to monitor and understand plant population dynamics.

  19. Matrix population models from 20 studies of perennial plant populations

    USGS Publications Warehouse

    Ellis, Martha M.; Williams, Jennifer L.; Lesica, Peter; Bell, Timothy J.; Bierzychudek, Paulette; Bowles, Marlin; Crone, Elizabeth E.; Doak, Daniel F.; Ehrlen, Johan; Ellis-Adam, Albertine; McEachern, Kathryn; Ganesan, Rengaian; Latham, Penelope; Luijten, Sheila; Kaye, Thomas N.; Knight, Tiffany M.; Menges, Eric S.; Morris, William F.; den Nijs, Hans; Oostermeijer, Gerard; Quintana-Ascencio, Pedro F.; Shelly, J. Stephen; Stanley, Amanda; Thorpe, Andrea; Tamara, Ticktin; Valverde, Teresa; Weekley, Carl W.

    2012-01-01

    Demographic transition matrices are one of the most commonly applied population models for both basic and applied ecological research. The relatively simple framework of these models and simple, easily interpretable summary statistics they produce have prompted the wide use of these models across an exceptionally broad range of taxa. Here, we provide annual transition matrices and observed stage structures/population sizes for 20 perennial plant species which have been the focal species for long-term demographic monitoring. These data were assembled as part of the 'Testing Matrix Models' working group through the National Center for Ecological Analysis and Synthesis (NCEAS). In sum, these data represent 82 populations with >460 total population-years of data. It is our hope that making these data available will help promote and improve our ability to monitor and understand plant population dynamics.

  20. Method of forming a ceramic matrix composite and a ceramic matrix component

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    de Diego, Peter; Zhang, James

    A method of forming a ceramic matrix composite component includes providing a formed ceramic member having a cavity, filling at least a portion of the cavity with a ceramic foam. The ceramic foam is deposited on a barrier layer covering at least one internal passage of the cavity. The method includes processing the formed ceramic member and ceramic foam to obtain a ceramic matrix composite component. Also provided is a method of forming a ceramic matrix composite blade and a ceramic matrix composite component.

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